MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Epigenetics and Chromatin' source. Sat, 20 Mar 2010 15:47:07 +0100 http://www.medworm.com/index.php?rid=3238575&cid=s_38184_50_f&fid=38184&url=http%3A%2F%2Fwww.epigeneticsandchromatin.com%2Fcontent%2F3%2F1%2F5 Conclusion: Taken together, these experiments suggest that the 19S proteasome plays a crucial role in the initial reorganization of events enabling the relaxation of the repressive chromatin structure surrounding inducible promoters. (Source: Epigenetics and Chromatin) Epigenetics and Chromatin journals http://www.medworm.com/rss/comments.php?id=3238575 Thu, 04 Feb 2010 00:00:00 +0100 3238575 http://www.medworm.com/index.php?rid=3184614&cid=s_38184_50_f&fid=38184&url=http%3A%2F%2Fwww.epigeneticsandchromatin.com%2Fcontent%2F3%2F1%2F3 Conclusions: Our study suggests that epigenetic transgene silencing can result from convergent transcription of inverted repeats which can lead to silencing of an entire multi-copy transgene array. This mechanism may account for a significant proportion of the reported cases of transgene inactivation in mice. (Source: Epigenetics and Chromatin) Epigenetics and Chromatin journals http://www.medworm.com/rss/comments.php?id=3184614 Tue, 19 Jan 2010 00:00:00 +0100 3184614 http://www.medworm.com/index.php?rid=3178086&cid=s_38184_50_f&fid=38184&url=http%3A%2F%2Fwww.epigeneticsandchromatin.com%2Fcontent%2F3%2F1%2F2 Conclusion: A large amount of data is produced from whole-genome expression and epigenetic profiling studies of cellular material. We have shown that such publicly available data can be mined and analysed in order to generate novel findings for categories of genes or regulatory elements. Comparing two types of gene regulation, imprinting and developmental, our results suggest that different histone modifications associate with these distinct processes. This form of analysis is therefore a useful tool to elucidate the complex epigenetic code associated with genome function and to determine the underlying features conferring epigenetic states. (Source: Epigenetics and Chromatin) Epigenetics and Chromatin journals http://www.medworm.com/rss/comments.php?id=3178086 Fri, 15 Jan 2010 00:00:00 +0100 3178086 http://www.medworm.com/index.php?rid=3162832&cid=s_38184_50_f&fid=38184&url=http%3A%2F%2Fwww.epigeneticsandchromatin.com%2Fcontent%2F3%2F1%2F1 Conclusions: These data provide evidence that the diversification of defined embryonic and extra-embryonic lineages is accompanied by chromatin remodelling at specific loci. Stem cell lines from the ICM, TE and PrE can each dominantly reprogramme somatic cells but reset gene expression differently, reflecting their separate lineage identities and increasingly restricted developmental potentials. (Source: Epigenetics and Chromatin) Epigenetics and Chromatin journals http://www.medworm.com/rss/comments.php?id=3162832 Tue, 12 Jan 2010 00:00:00 +0100 3162832 http://www.medworm.com/index.php?rid=3047187&cid=s_38184_50_f&fid=38184&url=http%3A%2F%2Fwww.epigeneticsandchromatin.com%2Fcontent%2F2%2F1%2F16 Conclusions: PcG silencers bind and coordinately regulate INK4b and INK4a, but not ARF, during a variety of physiological processes. Developmentally regulated EZH2 levels are one of the factors that can determine the higher order chromatin structure and expression pattern of the INK4b-ARF-INK4a locus, coupling human progenitor cell differentiation to proliferation control. Our results revealed a chromatin looping mechanism of long-range control and argue against models involving homogeneous spreading of PcG silencers across the INK4b-ARF-INK4a locus. (Source: Epigenetics and Chromatin) Epigenetics and Chromatin journals http://www.medworm.com/rss/comments.php?id=3047187 Wed, 02 Dec 2009 00:00:00 +0100 3047187 http://www.medworm.com/index.php?rid=3047186&cid=s_38184_50_f&fid=38184&url=http%3A%2F%2Fwww.epigeneticsandchromatin.com%2Fcontent%2F2%2F1%2F17 Conclusions: Our results suggest a central role of upstream promoter acetylation in the quantitative regulation of gene expression in this model gene. Induced core promoter acetylation is dispensable for the highest gene expression in the diurnal and circadian rhythm. (Source: Epigenetics and Chromatin) Epigenetics and Chromatin journals http://www.medworm.com/rss/comments.php?id=3047186 Wed, 02 Dec 2009 00:00:00 +0100 3047186 http://www.medworm.com/index.php?rid=3047185&cid=s_38184_50_f&fid=38184&url=http%3A%2F%2Fwww.epigeneticsandchromatin.com%2Fcontent%2F2%2F1%2F18 Conclusions: Our data identifies chromatin features that correlate with the silencing state and indicate that an array of phased nucleosomes is not sufficient for full repression. (Source: Epigenetics and Chromatin) Epigenetics and Chromatin journals http://www.medworm.com/rss/comments.php?id=3047185 Wed, 02 Dec 2009 00:00:00 +0100 3047185 http://www.medworm.com/index.php?rid=2995029&cid=s_38184_50_f&fid=38184&url=http%3A%2F%2Fwww.epigeneticsandchromatin.com%2Fcontent%2F2%2F1%2F15 Conclusions: Our experiments show a genetic and biochemical interaction between RNA Pol II (largest and second largest subunits) and the small RNA silencing machinery in Drosophila. The interaction has functional aspects in terms of determining H3K9me2 and HP-1 deposition at the chromocentric heterochromatin. Thus, RNA Pol II has an important role in establishing heterochromatin structure in Drosophila. (Source: Epigenetics and Chromatin) Epigenetics and Chromatin journals http://www.medworm.com/rss/comments.php?id=2995029 Mon, 16 Nov 2009 00:00:00 +0100 2995029 http://www.medworm.com/index.php?rid=2950040&cid=s_38184_50_f&fid=38184&url=http%3A%2F%2Fwww.epigeneticsandchromatin.com%2Fcontent%2F2%2F1%2F13 Epigenetics & Chromatin published its first papers a year ago, together with an editorial in which we stated our aim to publish a high-quality journal with a broad scope. A year later we are happy to report that these aims are being achieved. Papers published so far represent a broad swath of research on chromatin-based processes and epigenetic mechanisms. We are also delighted with the quality and breadth of submissions from many of the leading laboratories in the field. (Source: Epigenetics and Chromatin) Epigenetics and Chromatin journals http://www.medworm.com/rss/comments.php?id=2950040 Mon, 02 Nov 2009 00:00:00 +0100 2950040 http://www.medworm.com/index.php?rid=2868097&cid=s_38184_50_f&fid=38184&url=http%3A%2F%2Fwww.epigeneticsandchromatin.com%2Fcontent%2F2%2F1%2F12 Conclusions: Loss of ESET or Oct4 results in strikingly similar phenotypes both in ES cells with their differentiation into trophectoderm cells, and in early embryos where there is a failure of development of the pluripotent inner cell mass (ICM) of blastocysts. We propose that SUMOylated ESET-Oct4 complex is critical for both the initiation and maintenance of pluripotency through repression of differentiation, particularly of the trophectoderm lineage by epigenetic silencing of Cdx2. (Source: Epigenetics and Chromatin) Epigenetics and Chromatin journals http://www.medworm.com/rss/comments.php?id=2868097 Tue, 06 Oct 2009 23:00:00 +0100 2868097 http://www.medworm.com/index.php?rid=2784947&cid=s_38184_50_f&fid=38184&url=http%3A%2F%2Fwww.epigeneticsandchromatin.com%2Fcontent%2F2%2F1%2F11 Conclusions: Our results suggest that there may be a memory or an epigenetic mark on the nucleosome-depleted PHO5 promoter that is independent of the transcription apparatus and maintains the promoter in a nucleosome-depleted state through DNA replication. (Source: Epigenetics and Chromatin) Epigenetics and Chromatin journals http://www.medworm.com/rss/comments.php?id=2784947 Thu, 10 Sep 2009 23:00:00 +0100 2784947 http://www.medworm.com/index.php?rid=2616409&cid=s_38184_50_f&fid=38184&url=http%3A%2F%2Fwww.epigeneticsandchromatin.com%2Fcontent%2F2%2F1%2F8 Conclusions: These data point toward a role for transcription of non-coding RNAs as a developmental strategy for the establishment of functionally distinct domains within the mammalian genome. (Source: Epigenetics and Chromatin) Epigenetics and Chromatin journals http://www.medworm.com/rss/comments.php?id=2616409 Sun, 19 Jul 2009 23:00:00 +0100 2616409 http://www.medworm.com/index.php?rid=2467172&cid=s_38184_50_f&fid=38184&url=http%3A%2F%2Fwww.epigeneticsandchromatin.com%2Fcontent%2F2%2F1%2F7 Conclusion: The varied patterns of methylation differences detected between tissues by our methylation profiling method reinforce the potential functional significance of regional differences in methylation levels outside of CpG islands. (Source: Epigenetics and Chromatin) Epigenetics and Chromatin journals http://www.medworm.com/rss/comments.php?id=2467172 Mon, 08 Jun 2009 04:00:00 +0100 2467172 http://www.medworm.com/index.php?rid=2411620&cid=s_38184_50_f&fid=38184&url=http%3A%2F%2Fwww.epigeneticsandchromatin.com%2Fcontent%2F2%2F1%2F6 Conclusions: In agreement with its proposed role in the initiation of DNA replication, GINS proteins associated with chromatin near sites of ORC binding that were devoid of EdU (absence of DNA replication). The association of GINS proteins with PCNA was consistent with a role in the process of elongation. Additionally, the large size of our chromatin fibers (up to approximately 7 Mb) allowed for a more expansive analysis of the distance between active replicons than previously reported. (Source: Epigenetics and Chromatin) Epigenetics and Chromatin journals http://www.medworm.com/rss/comments.php?id=2411620 Thu, 14 May 2009 04:00:00 +0100 2411620 http://www.medworm.com/index.php?rid=2320539&cid=s_38184_50_f&fid=38184&url=http%3A%2F%2Fwww.epigeneticsandchromatin.com%2Fcontent%2F2%2F1%2F5 Conclusions: These data suggest a bimodal recruit and maintain model whereby Mll2 is required to establish certain epigenetic decisions during differentiation, which are then maintained by redundant mechanisms. We also suggest that these mechanisms relate to the epigenetic maintenance of CpG island promoters. (Source: Epigenetics and Chromatin) Epigenetics and Chromatin journals http://www.medworm.com/rss/comments.php?id=2320539 Mon, 06 Apr 2009 04:00:00 +0100 2320539 http://www.medworm.com/index.php?rid=2272037&cid=s_38184_50_f&fid=38184&url=http%3A%2F%2Fwww.epigeneticsandchromatin.com%2Fcontent%2F2%2F1%2F4 Conclusions: On a gene locus, multiple nucleosome positions are directed by a gene sequence to provide a pool of possibilities, out of which the preferred ones are selected by the chromatin remodeler and transcription factor of the gene under different states of activity of the gene. (Source: Epigenetics and Chromatin) Epigenetics and Chromatin journals http://www.medworm.com/rss/comments.php?id=2272037 Mon, 16 Mar 2009 04:00:00 +0100 2272037 http://www.medworm.com/index.php?rid=2255542&cid=s_38184_50_f&fid=38184&url=http%3A%2F%2Fwww.epigeneticsandchromatin.com%2Fcontent%2F2%2F1%2F3 Conclusions: In this study we demonstrate the validity of using pooled DNA samples to accurately assess group DNA methylation averages. Such an approach can be readily applied to the assessment of disease phenotypes reducing the time, cost and amount of DNA starting material required for large-scale epigenetic analyses. (Source: Epigenetics and Chromatin) Epigenetics and Chromatin journals http://www.medworm.com/rss/comments.php?id=2255542 Tue, 10 Mar 2009 04:00:00 +0100 2255542 http://www.medworm.com/index.php?rid=2196396&cid=s_38184_50_f&fid=38184&url=http%3A%2F%2Fwww.epigeneticsandchromatin.com%2Fcontent%2F2%2F1%2F2 Spinocerebellar ataxia (SCA) is a physically devastating, genetically inherited disorder characterized by abnormal brain function that results in the progressive loss of the ability to coordinate movements. There are many types of SCAs as there are various gene mutations that can cause this disease. SCA types 1-3, 6-10, 12, and 17 result from a trinucleotide repeat expansion in the DNA-coding sequence. Intriguingly, recent work has demonstrated that increased trinucleotide repeat expansions result in defects in the function of the SAGA histone acetyltransferase complex. The SCA7 gene encodes a subunit of the SAGA complex. This subunit is conserved in yeast as the SGF73 gene. We demonstrate that SGF73 is required to recruit the histone deubiquitination module into both SAGA and the related ... Epigenetics and Chromatin journals http://www.medworm.com/rss/comments.php?id=2196396 Wed, 18 Feb 2009 05:00:00 +0100 2196396 http://www.medworm.com/index.php?rid=2142604&cid=s_38184_50_f&fid=38184&url=http%3A%2F%2Fwww.epigeneticsandchromatin.com%2Fcontent%2F2%2F1%2F1 Conclusions: Our molecular maps demonstrate that heterochromatin can invade a normally euchromatic region, yet the strength of HP1 binding and effects on gene expression are highly dependent on local context. Our data suggest that the white gene has an unusual intrinsic affinity for heterochromatin, which may cause this gene to be more sensitive to PEV than most other genes. (Source: Epigenetics and Chromatin) Epigenetics and Chromatin journals http://www.medworm.com/rss/comments.php?id=2142604 Thu, 29 Jan 2009 05:00:00 +0100 2142604 http://www.medworm.com/index.php?rid=2043757&cid=s_38184_50_f&fid=38184&url=http%3A%2F%2Fwww.epigeneticsandchromatin.com%2Fcontent%2F1%2F1%2F10 Conclusions: Efficient and highly specific recognition of CenH3 in histone core particles isolated from native centromeric chromatin demonstrates that tetramers are the predominant form of centromeric nucleosomes in mature tetramers. Our findings provide proof of principle that this approach can yield insights into chromatin biology using direct and rapid detection of native nucleosomes in physiological salt concentrations. (Source: Epigenetics and Chromatin) Epigenetics and Chromatin journals http://www.medworm.com/rss/comments.php?id=2043757 Wed, 17 Dec 2008 05:00:00 +0100 2043757