MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Epilepsy and Behaviour' source. Sat, 20 Mar 2010 14:40:58 +0100 http://www.medworm.com/index.php?rid=3383714&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20236867%26dopt%3DAbstract This study underscores the importance of recognizing the significant attributes of videos that engage the viewers. PMID: 20236867 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3383714 Mon, 15 Mar 2010 00:00:00 +0100 3383714 http://www.medworm.com/index.php?rid=3383713&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20236868%26dopt%3DAbstract Authors: Demirtas-Tatlidede A, Yalcin AD, Uysal E, Forta H The purpose of this study was to retrospectively evaluate the cognitive and electroclinical characteristics of right cerebral hemiatrophy (Dyke-Davidoff-Masson syndrome [DDMS]). Cognitive assessments with a particular emphasis on visuospatial functions, electroclinical features, and neuroimaging characteristics were analyzed for five patients with a clinically and neuroradiologically confirmed diagnosis of right-sided DDMS. Intelligence tests revealed mental retardation in all but one. Neuropsychological assessments demonstrated consistent impairments in tasks that have a spatial component (spatial processing and orientation discrimination), whereas attention, executive functions and verbal memory domains were variably impaired... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3383713 Mon, 15 Mar 2010 00:00:00 +0100 3383713 http://www.medworm.com/index.php?rid=3383712&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20236869%26dopt%3DAbstract Authors: Wilner A, Keezer MR, Andermann F A woman known to have never fully controlled idiopathic generalized epilepsy presented at 47years of age with a new onset of drop attacks. After clinical investigations, including prolonged video/EEG telemetry, tilt-table testing, and multiple sleep latency tests, the etiology of her drop attacks remained elusive. Subsequently we were able to demonstrate that her drop attacks may be provoked by her voluntary recollection of memories of past sexual abuse. This case study highlights the need to consider psychological factors when evaluating otherwise unexplained drop attacks. In addition, we propose a seizure-provoking technique that may be used both effectively and ethically in the diagnosis of psychogenic drop attacks as well as nonepileptic se... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3383712 Mon, 15 Mar 2010 00:00:00 +0100 3383712 http://www.medworm.com/index.php?rid=3383711&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20236870%26dopt%3DAbstract Authors: Vignoli A, Fabio RA, La Briola F, Giannatiempo S, Antonietti A, Maggiolini S, Canevini MP Rett syndrome, a neurodevelopmental disorder affecting mainly females, is caused by a mutation of the MeCP2 gene. Girls with Rett syndrome manifest diverse behavioral and cognitive phenotypes, and the reasons for this variability remain unknown. In addition, girls with Rett syndrome often have epileptic seizures and abnormal EEGs, the characteristics of which differ with the patient. The aim of the study was to verify if neurophysiological and epileptological characteristics could be correlated with cognitive measures, obtained using eye tracker technology, and behavioral scores (Vineland Adaptive Behavior Scales and Rett Assessment Rating Scale) in 18 patients with Rett syndrome (mean ag... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3383711 Mon, 15 Mar 2010 00:00:00 +0100 3383711 http://www.medworm.com/index.php?rid=3375086&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20227922%26dopt%3DAbstract CONCLUSION: We found that there was a decline in both sense of coherence and self-esteem over time for young adults with epilepsy. Growing up with epilepsy can lead to impairment of sense of coherence. Sense of coherence does not significantly correlate with epilepsy-related factors, but mirrors the phenomenon of epilepsy. Self-esteem is associated with such epilepsy-related factors as seizure frequency. PMID: 20227922 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3375086 Fri, 12 Mar 2010 00:00:00 +0100 3375086 http://www.medworm.com/index.php?rid=3375087&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20227351%26dopt%3DAbstract Authors: Szaflarski JP, Lindsell CJ, Zakaria T, Banks C, Privitera MD In a minority of patients with idiopathic generalized epilepsies (IGEs), seizures continue despite appropriate treatment. We sought to determine the clinical and EEG factors associated with medication response in these patients. All patients with IGEs evaluated by epilepsy specialists between 17 November 2008 and 16 November 2009 were included. We collected information on seizure freedom (dependent variable), EEG asymmetries, response to valproic acid (VPA), MRI characteristics, medication use, demographics, and seizure history (predictors). We identified 322 patients with IGEs; 45 (14%) were excluded from analyses because they had always had a normal EEG (N=26), there were no EEG data (N=3), or they were non-complia... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3375087 Thu, 11 Mar 2010 00:00:00 +0100 3375087 http://www.medworm.com/index.php?rid=3359441&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20215042%26dopt%3DAbstract Authors: Chong J, Kudrimoti HS, Lopez DC, Labiner DM Modifiable risk factors to help improve health outcomes for people with epilepsy in Arizona were identified using the 2005-2006 Arizona Behavioral Risk Factor Surveillance System (BRFSS). Of 9524 adults who participated in this survey, 125 reported ever being diagnosed with epilepsy (lifetime prevalence=1.3%, 95% CI=1.1-1.6%). Individuals with active epilepsy (those who had seizures in the prior 3 months and/or were taking anticonvulsants) had an overall lower quality of life. This likely resulted from a large number of medical comorbidities and poor mental and physical health days. Regression models suggested that for individuals with active epilepsy, physical activity was associated with fewer activity-limited days, whereas for ind... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3359441 Mon, 08 Mar 2010 00:00:00 +0100 3359441 http://www.medworm.com/index.php?rid=3359440&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20219435%26dopt%3DAbstract Authors: Metternich B, Wagner K, Schulze-Bonhage A PMID: 20219435 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3359440 Mon, 08 Mar 2010 00:00:00 +0100 3359440 http://www.medworm.com/index.php?rid=3359439&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20219436%26dopt%3DAbstract Authors: Taylor D PMID: 20219436 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3359439 Mon, 08 Mar 2010 00:00:00 +0100 3359439 http://www.medworm.com/index.php?rid=3350870&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20207589%26dopt%3DAbstract This study sought to explore the relationship between verbal memory and the experience of déjà vu or other types of mnemestic auras in 42 individuals with intractable seizures and 42 age- and education-matched patient controls. Verbal memory was assessed with indices of learning, long delay recall, and recognition from the California Verbal Learning Test. Results indicated that auras of any type were not associated with memory performance on the California Verbal Learning Test. As expected, age and education were related to verbal memory performance. Mnemestic auras were associated with clinical indices of illness, suggesting that the presence of these auras may be regarded as a risk factor for greater chronicity and severity in epilepsy. PMID: 20207589 [PubMed - as supplied ... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3350870 Fri, 05 Mar 2010 00:00:00 +0100 3350870 http://www.medworm.com/index.php?rid=3350871&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20207201%26dopt%3DAbstract Authors: Stephen LJ, Kelly K, Wilson EA, Parker P, Brodie MJ This audit examined outcomes for 203 patients prescribed zonisamide (ZNS) for various uncontrolled seizure types at a specialist outpatient service. Forty-two (20.7%) patients achieved 6months of seizure freedom, and an additional 37 (18.2%) had a 50% seizure reduction for 6months on a stable ZNS dose. Seizure freedom was more likely in patients with primary generalized (24/61, 39%) than in those with partial-onset (18/141, 12.7%) seizures (P<0.001). Eight patients (5 seizure free) were maintained on ZNS monotherapy. More patients became seizure free with ZNS as monotherapy or first add-on, compared with those in whom ZNS was the second, third, or fourth adjunctive drug (P=0.001). Seizure freedom was less likely in patient... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3350871 Thu, 04 Mar 2010 00:00:00 +0100 3350871 http://www.medworm.com/index.php?rid=3338951&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20199891%26dopt%3DAbstract Authors: Cunha I, Oliveira J The authors carried out a 5-year prospective study about the effects epilepsy surgery can have on a patient's quality of life (QOL). They looked for the relationship between improvement on QOL after surgery and reduction of seizure frequency, seizure focus, age at surgery and previous psychopathology. They concluded that improvement in overall, cognitive and social function scores were statistically significant throughout the study. Seizure worry score ceased to be significant at the fifth year. Previous psychopathology was a negative influence on social and seizure worry score. Compared to left lobectomies, right lobectomies showed significant better results in overall scores at six months and one year follow-up. At 1 month follow-up, cognitive function wa... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3338951 Tue, 02 Mar 2010 00:00:00 +0100 3338951 http://www.medworm.com/index.php?rid=3323347&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20189885%26dopt%3DAbstract Authors: Saengpattrachai M, Srinualta D, Lorlertratna N, Pradermduzzadeeporn E, Poonpol F The purpose of this nationwide survey was to assess familiarity with and knowledge of epilepsy, as well as to identify predictors of negative attitudes toward people with epilepsy, in Thailand. Of the 1581 people interviewed, 80.8% were familiar with the word epilepsy, but few knew anyone with the condition. The main reason given for avoiding helping a seizure victim was a lack of proper first-aid knowledge, not a negative attitude toward the person. The factors predicting negative attitudes in the Thai population were low educational level, unfamiliarity with epilepsy, and the misconception that epilepsy is a form of insanity. Different from most previous studies worldwide, the attitudes of frien... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3323347 Fri, 26 Feb 2010 00:00:00 +0100 3323347 http://www.medworm.com/index.php?rid=3323346&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20189886%26dopt%3DAbstract Authors: Schmitt FC, Dehnicke C, Merschhemke M, Meencke HJ In the scenario of refractory status epilepticus, the recommended approach of intensive care treatment is limited with respect to the available pharmacodynamic variability and its impeding, severe side effects. Alternative treatment options are therefore urgently needed. In the case described, a patient with nonlesional frontal lobe epilepsy had a high-frequency series of tonic seizures, which evolved into a malignant form of status epilepticus. Co-administration of verapamil, a potent multidrug transporter inhibitor, was followed by significant reduction in seizure frequency. We discuss the putative role of verapamil and the specific risk factors for this malignant treatment course. PMID: 20189886 [PubMed - as supplied by ... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3323346 Fri, 26 Feb 2010 00:00:00 +0100 3323346 http://www.medworm.com/index.php?rid=3323348&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20189461%26dopt%3DAbstract We examined the neuropsychological phenotype of ADNFLE, with a particular emphasis on understanding the impact on frontal lobe functions. We used standard clinical tests as well as focused measures of frontal lobe function in a well-defined group of patients with ADNFLE. Their performance was compared with that of a group of age-, sex-, and education-matched control participants. Patients with ADNFLE showed impairments on tasks requiring cognitive flexibility against a background of well-preserved intellectual abilities. In accord with existing research, verbal memory impairments were identified in the patient group; the level of impairment on these tasks correlated with disease-related factors. In our study of ADNFLE associated with one mutation, cognitive flexibility appears to be the co... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3323348 Thu, 25 Feb 2010 00:00:00 +0100 3323348 http://www.medworm.com/index.php?rid=3323349&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20188634%26dopt%3DAbstract The objective of the study described here was to evaluate the efficacy, tolerability, and cognitive effects of levetiracetam (LEV) in patients with seizures and Alzheimer's disease (AD). This was a prospective, randomized, three-arm parallel-group, case-control study of 95 patients taking LEV (n=38), phenobarbital (PB) (n=28), and lamotrigine (LTG) (n=29). A 4-week dose adjustment was followed by a 12-month evaluation period. The three groups were compared to a control group (n=68) to evaluate cognitive effects of the antiepileptic drugs. We examined drug effects cross-sectionally at baseline, 6months, and 12months. There were no significant differences in efficacy among the three AEDs. LEV caused fewer adverse events than the other AEDs. PB produced persistent negative cognitive side effe... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3323349 Wed, 24 Feb 2010 00:00:00 +0100 3323349 http://www.medworm.com/index.php?rid=3314842&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20185371%26dopt%3DAbstract Authors: Scorza FA PMID: 20185371 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3314842 Tue, 23 Feb 2010 00:00:00 +0100 3314842 http://www.medworm.com/index.php?rid=3314841&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20185372%26dopt%3DAbstract CONCLUSIONS: The present data suggest that RUF is efficacious and well tolerated in the long-term treatment of children and adults with various epilepsy syndromes and difficult-to-control seizures. PMID: 20185372 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3314841 Tue, 23 Feb 2010 00:00:00 +0100 3314841 http://www.medworm.com/index.php?rid=3314840&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20185373%26dopt%3DAbstract Authors: Tuchscherer V, Seidenberg M, Pulsipher D, Lancaster M, Guidotti L, Hermann B Chronic temporal lobe epilepsy (TLE) is characterized by the presence of extra-hippocampal brain abnormality and cognitive impairment in both memory and nonmemory domains. However, the link between structural integrity and cognition has not frequently been studied. Forty-six patients with TLE and 61 age-matched controls were studied to determine the predictive relationship between baseline thalamic volume and performance on measures of executive functioning evaluated 4years later. As expected, the TLE group had lower baseline thalamic volumes than controls and also performed more poorly on measures of executive functioning. Total thalamic volume significantly predicted subsequent performance on all th... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3314840 Tue, 23 Feb 2010 00:00:00 +0100 3314840 http://www.medworm.com/index.php?rid=3314844&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20181534%26dopt%3DAbstract We describe a patient with seizures arising from right anterior-inferior frontal lobe presenting as myoclonic epilepsy. A 19-year-old man had experienced frequent paroxysmal bilateral myoclonic jerks involving his upper arms, shoulders, neck, and upper trunk since the age of 10. His baseline EEG showed intermittent right frontal spikes, and his ictal EEG showed rhythmic sharp theta discharges in the same area. MRI revealed cortical dysplasia in the right inferior frontal gyrus, and ictal-interictal SPECT analysis by SPM showed increased signal abnormality in this region. Diffusion tensor imaging (DTI) showed defects in fasciculi in the same area. These findings suggest that frontal lobe epilepsy should be considered in some patients with myoclonic seizures. PMID: 20181534 [PubMed - as ... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3314844 Mon, 22 Feb 2010 00:00:00 +0100 3314844 http://www.medworm.com/index.php?rid=3314843&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20181535%26dopt%3DAbstract Authors: Hoppe C, Witt JA, Helmstaedter C PMID: 20181535 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3314843 Mon, 22 Feb 2010 00:00:00 +0100 3314843 http://www.medworm.com/index.php?rid=3307328&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20171932%26dopt%3DAbstract Authors: Baum KT, Byars AW, Degrauw TJ, Dunn DW, Bates JE, Howe SR, Chiu CY, Austin JK The present study is part of a larger project that seeks to identify factors that predict children's behavioral, social, and cognitive adaptation to epilepsy. Children with seizures are more likely to have internalizing and externalizing behavior problems than either healthy children or children with other chronic illnesses. The present research examines risk factors for behavior problems. Early temperament and neuropsychological functioning, specifically executive function and language abilities, are evaluated as unique and moderating predictors of adverse behavioral outcomes in 229 children with a first recognized seizure. Parents assessed temperament, children were administered neuropsychological ... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3307328 Thu, 18 Feb 2010 00:00:00 +0100 3307328 http://www.medworm.com/index.php?rid=3307331&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20171144%26dopt%3DAbstract We report the clinical course of a patient with bitemporal epilepsy who ingested 12g of lacosamide, 56g of gabapentin, 2g of topiramate, and 2.8g of zonisamide during a suicide attempt. The patient was found comatose and experienced repeated generalized tonic-clonic seizures, aspiration with subsequent pneumonia, hypotension, and an increase in PR interval. Complete physical recovery occurred after several days of supportive treatment. We conclude that intoxication with lacosamide, in combination with overdoses of multiple AEDs, can be survived without sequelae, even after ingestion of 12g lacosamide. PMID: 20171144 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3307331 Wed, 17 Feb 2010 00:00:00 +0100 3307331 http://www.medworm.com/index.php?rid=3307330&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20171145%26dopt%3DAbstract We report a case of late-onset PRES with atypical localization following liver transplantation. The patient developed epilepsy despite resolution of MRI lesions at 8months of follow-up. EEG was a prognostic factor of seizure persistence, suggesting an incomplete recovery of brain lesions in contrast to neuroimaging findings. PMID: 20171145 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3307330 Wed, 17 Feb 2010 00:00:00 +0100 3307330 http://www.medworm.com/index.php?rid=3307329&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20171146%26dopt%3DAbstract We describe a case of reflex seizures induced by abstract reasoning but not other cognitive processes. The patient, a 46-year-old man, experienced myoclonic seizures whenever he played shogi (Japanese chess). To identify the critical thought processes responsible for inducing his seizures, we monitored his clinical seizures and epileptiform discharges while he performed comprehensive neuropsychological tests, including the Wechsler Adult Intelligence Scale-Revised (WAIS-R), spatial working memory, mental rotation, and Wisconsin Card Sorting Test (WCST) tasks. A myoclonic seizure occurred only during the WCST. Generalized 3- to 5-Hz spike-and-slow-wave bursts occurred repeatedly during the Block Design subtest of the WAIS-R and the WCST, whereas no discharges occurred during other subtests ... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3307329 Wed, 17 Feb 2010 00:00:00 +0100 3307329 http://www.medworm.com/index.php?rid=3288769&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20159660%26dopt%3DAbstract We present data from human and animal studies supporting the role of exercise as a therapy for epilepsy complementary to standard treatments. PMID: 20159660 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3288769 Mon, 15 Feb 2010 00:00:00 +0100 3288769 http://www.medworm.com/index.php?rid=3288768&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20163992%26dopt%3DAbstract We describe a 61-year-old patient with clinical evidence of limbic encephalitis who improved with anticonvulsant treatment only, that is, without the use of immunosuppressive agents. Three years following occurrence of anosmia, increasing memory deficits, and emotional disturbances, he presented with new-onset temporal lobe epilepsy, with antibodies binding to neuronal voltage-gated potassium channels and bitemporal hypometabolism on FDG-PET scan; the MRI scan was normal. This is most likely a case of spontaneous remission, illustrating that immunosuppressive therapy might be suspended in milder courses of limbic encephalitis. It remains open whether treatment with anticonvulsant drugs played an additional beneficiary role through the direct suppression of seizures or, additionally, throug... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3288768 Mon, 15 Feb 2010 00:00:00 +0100 3288768 http://www.medworm.com/index.php?rid=3288767&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20163993%26dopt%3DAbstract Authors: Kalitzin SN, Velis DN, Lopes da Silva FH We focus on the implications that the underlying neuronal dynamics might have on the possibility of anticipating seizures and designing an effective paradigm for their control. Transitions into seizures can be caused by parameter changes in the dynamic state or by interstate transitions as occur in multi-attractor systems; in the latter case, only a weak statistical prognosis of the seizure risk can be achieved. Nevertheless, we claim that by applying a suitable perturbation to the system, such as electrical stimulation, relevant features of the system's state may be detected and the risk of an impending seizure estimated. Furthermore, if these features are detected early, transitions into seizures may be blocked. On the basis of generi... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3288767 Mon, 15 Feb 2010 00:00:00 +0100 3288767 http://www.medworm.com/index.php?rid=3273297&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20153981%26dopt%3DAbstract Authors: Black LC, Schefft BK, Howe SR, Szaflarski JP, Yeh HS, Privitera MD The aim of this study was to assess whether duration of seizure disorder and lifetime seizure load are associated with deficits in higher cognitive functions in patients with temporal lobe epilepsy (TLE) (N=207) or psychogenic nonepileptic seizures (PNES) (N=216). Multivariate regression analyses revealed that age at onset, duration, and group assignment were significant predictors of neuropsychological performance (all P0.02), with group having a moderating relationship. Univariate analyses revealed different patterns of predictor effects on cognitive functioning within each diagnostic group. An impairment index was calculated for each individual, and univariate analyses revealed that age at TLE but not PNES o... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3273297 Fri, 12 Feb 2010 00:00:00 +0100 3273297 http://www.medworm.com/index.php?rid=3273296&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20153982%26dopt%3DAbstract CONCLUSION: DHA increases resistance to PTZ-induced seizures without altering measures of sedation and, apparently, without changing DHA concentrations in serum or brain. PMID: 20153982 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3273296 Fri, 12 Feb 2010 00:00:00 +0100 3273296 http://www.medworm.com/index.php?rid=3273295&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20153983%26dopt%3DAbstract Authors: Sahaya K, Lardizabal D A 20-year-old woman was admitted for psychosis. On further investigation, she was found to be have viral encephalitis and generalized nonconvulsive seizures. After the seizures were controlled, she remained in a prolonged catatonic state. Repeated intravenous benzodiazepine administration, improved her cognition dramatically. This case emphasizes that catatonia may occur after encephalitis and nonconvulsive seizures. PMID: 20153983 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3273295 Fri, 12 Feb 2010 00:00:00 +0100 3273295 http://www.medworm.com/index.php?rid=3273298&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20153701%26dopt%3DAbstract CONCLUSION: The knowledge level in this student sample is high, but the relatively low proportion of respondents who have read about epilepsy suggests that the observed high level of awareness of epilepsy may be from knowledge gained in the community; thus, there exist knowledge gaps. Therefore, a teaching course on epilepsy needs to be introduced into the curriculum of these training schools as early as the first year of studies. The course content must take into account the belief and value systems of the community and address misconceptions about epilepsy. PMID: 20153701 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3273298 Thu, 11 Feb 2010 00:00:00 +0100 3273298 http://www.medworm.com/index.php?rid=3273300&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20153260%26dopt%3DAbstract Authors: Mathew J, Peeyush Kumar T, Khan RS, Paulose CS In the present study, the effects of Bacopa monnieri and its active component, bacoside A, on motor deficit and alterations of GABA receptor functional regulation in the cerebellum of epileptic rats were investigated. Scatchard analysis of [(3)H]GABA and [(3)H]bicuculline in the cerebellum of epileptic rats revealed a significant decrease in B(max) compared with control. Real-time polymerase chain reaction amplification of GABA(A) receptor subunits-GABA(Aalpha1), GABA(Aalpha5,) and GABA(Adelta)-was downregulated (P<0.001) in the cerebellum of epileptic rats compared with control rats. Epileptic rats exhibit deficits in radial arm and Y-maze performance. Treatment with B. monnieri and bacoside A reversed these changes to near-co... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3273300 Wed, 10 Feb 2010 00:00:00 +0100 3273300 http://www.medworm.com/index.php?rid=3273299&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20153261%26dopt%3DAbstract Authors: Bertti P, Dal-Cól ML, Wichert-Ana L, Kato M, Terra VC, de Oliveira JA, Velasco TR, Sakamoto AC, Garcia-Cairasco N Ictal behavior coupled with SPECT findings during 28 seizures in patients with temporal lobe epilepsy (TLE) with unilateral hippocampal sclerosis (13 left; 15 right) was displayed as flowcharts from right-sided (RTLE) plus left-sided (LTLE) seizures. Ictal SPECT was classified blind to neuroethology. Behaviors were categorized as ipsilateral to the epileptogenic zone (IL), contralateral to the epileptogenic zone (CL), or bilateral. SPECT intensity and region were categorized as IL or CL to the epileptogenic zone. All patients developed automatisms and had hyperperfusion in their temporal lobes. Patients' verbal responses to questions had statistical interactio... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3273299 Wed, 10 Feb 2010 00:00:00 +0100 3273299 http://www.medworm.com/index.php?rid=3270709&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20149754%26dopt%3DAbstract CONCLUSION: Voxel-based mapping supports the assertion that glucose hypometabolism of the epileptogenic temporal lobe cortex and other neighboring cortical regions increases with longer epilepsy duration in TLE. PMID: 20149754 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3270709 Tue, 09 Feb 2010 00:00:00 +0100 3270709 http://www.medworm.com/index.php?rid=3270708&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20149755%26dopt%3DAbstract In this study the relationship between language skill and frontotemporal volumes was compared in 69 medically treated subjects with epilepsy and 34 healthy children, aged 6.1-16.6years. Also, whether patients with linguistic deficits had abnormal volumes and atypical associations between volumes and language skills in these brain regions was determined. The children underwent language testing and MRI scans at 1.5 T. Brain tissue was segmented and frontotemporal volumes were computed. Higher mean language scores were significantly associated with larger inferior frontal gyrus, temporal lobe, and posterior superior temporal gyrus gray matter volumes in the epilepsy group and in the children with epilepsy with average language scores. Increased total brain and dorsolateral prefrontal gray and... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3270708 Tue, 09 Feb 2010 00:00:00 +0100 3270708 http://www.medworm.com/index.php?rid=3270707&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20149756%26dopt%3DAbstract Authors: Saetre E, Abdelnoor M, Perucca E, Taubøll E, Isojärvi J, Gjerstad L During an international double-blind trial evaluating the efficacy and tolerability of lamotrigine and carbamazepine in patients aged 65 with newly diagnosed epilepsy, the comparative effects of the drugs on health-related quality of life were investigated based on screening and 12-, 28-, and 40-week data, using the modified Side Effect and Life Satisfaction (SEALS) Inventory and the Liverpool Adverse Event Profile. Of 167 patients, 29 discontinued before first follow-up, and data were incomplete for 13. In 125 eligible subjects (62 taking carbamazepine, 63 taking lamotrigine), comparable baseline data did not change significantly during medication, within or across treatments. A borderline differenc... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3270707 Mon, 08 Feb 2010 00:00:00 +0100 3270707 http://www.medworm.com/index.php?rid=3270706&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20149757%26dopt%3DAbstract This article describes the clinical features of psychogenic nonepileptic seizures (PNES) in people in southwest China. Patients with a confirmed diagnosis of pure PNES by video/EEG monitoring were retrospectively reviewed. A total of 64 patients with PNES were included, 32 (50%) of whom were male. Twenty (31.3%) patients had previously been misdiagnosed and treated for epilepsy. Psychological trauma and head injuries were considered antecedent traumatic factors. A history of abuse was rare. The PNES cases were divided into three subtypes: psychogenic minor motor seizures, psychogenic major motor seizures, and unresponsive seizures. Age at onset was identified as a predictor of prognosis. The results of this study demonstrated a higher prevalence of PNES in males compared with previous stud... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3270706 Mon, 08 Feb 2010 00:00:00 +0100 3270706 http://www.medworm.com/index.php?rid=3267287&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20144880%26dopt%3DAbstract Authors: Osorio I PMID: 20144880 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3267287 Mon, 08 Feb 2010 00:00:00 +0100 3267287 http://www.medworm.com/index.php?rid=3267288&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20144879%26dopt%3DAbstract Authors: Visweswari G, Prasad KS, Chetan PS, Lokanatha V, Rajendra W The study described here was carried out to investigate the anticonvulsant effect of different extracts of Centella asiatica with respect to cholinergic activity on pentylenetetrazol (PTZ)-induced seizures. Rats were randomly divided into eight groups of six rats each: nonepileptic rats treated with saline; PTZ (60mg/kg, IP)-induced seizure rats treated with saline; PTZ-induced seizure rats pretreated with n-hexane, chloroform, ethyl acetate, n-butanol, and water extracts of C. asiatica; and PTZ-induced seizure rats pretreated with diazepam (2mg/kgbodywt). The seized rats pretreated with different extracts were administered a dose of 200mg/kgbodywt orally for 1week before induction of epilepsy. Increased acetylcholine... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3267288 Sun, 07 Feb 2010 00:00:00 +0100 3267288 http://www.medworm.com/index.php?rid=3259481&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20138587%26dopt%3DAbstract Authors: Stefanello S, Marín-Léon L, Fernandes PT, Min LL, Botega NJ Epilepsy has been associated with increased risk of suicide; however, few studies have examined the relationship between epilepsy and suicidal behavior. The aims of this study were to evaluate the frequency of suicidal behavior in people with epilepsy and to identify characteristics that are associated with suicidal ideation in epilepsy. Of 171 people with epilepsy identified in a previous survey, 139 were included. A structured interview was conducted, and a second psychiatric evaluation was scheduled for those who agreed. The frequencies of suicidal thoughts, plans, and attempts during lifetime were 36.7, 18.2, and 12.1%, respectively. The following conditions were strongly associated with suicidal thought... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3259481 Thu, 04 Feb 2010 00:00:00 +0100 3259481 http://www.medworm.com/index.php?rid=3259480&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20138588%26dopt%3DAbstract Authors: Kalinin VV, Zemlyanaya AA, Krylov OE, Zheleznova EV The aim of the current study was to evaluate the effect of seizure lateralization, handedness, and alexithymia on psychopathology in patients with temporal lobe epilepsy. One hundred five patients were included in the study. The Hopkins Symptom Checklist-90 (SCL-90) and Toronto Alexithymia Scale (TAS-26) were used for psychopathological assessment of patients. Handedness was evaluated using Annett's scale. Among the patients studied were 74 right-handers and 31 left-handers, and 25 alexithymic and 80 nonalexithymic persons. Left-sided foci were observed in 52, and right-sided foci in 53 persons. MANOVA was used for analysis of the interrelationship between nominal fixed factors (handedness, alexithymia, and focus laterality) ... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3259480 Thu, 04 Feb 2010 00:00:00 +0100 3259480 http://www.medworm.com/index.php?rid=3247530&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20133208%26dopt%3DAbstract Authors: Matos G, Tsai R, Baldo MV, de Castro I, Sameshima K, Valle AC The relationship between sleep and epilepsy is both complex and clinically significant. Temporal lobe epilepsy (TLE) influences sleep architecture, while sleep plays an important role in facilitating and/or inhibiting possible epileptic seizures. The pilocarpine experimental model reproduces several features of human temporal lobe epilepsy and is one of the most widely used models in basic research. The aim of the present study was to characterize, behaviorally and electrophysiologically, the phases of sleep-wake cycles (SWC) in male rats with pilocarpine-induced epilepsy. Epileptic rats presented spikes in all phases of the SWC as well as atypical cortical synchronization during attentive wakefulness and paradoxica... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3247530 Tue, 02 Feb 2010 00:00:00 +0100 3247530 http://www.medworm.com/index.php?rid=3232409&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20116336%26dopt%3DAbstract Authors: Sirven JI PMID: 20116336 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3232409 Wed, 27 Jan 2010 00:00:00 +0100 3232409 http://www.medworm.com/index.php?rid=3232408&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20116337%26dopt%3DAbstract Authors: Hum KM, Smith ML, Lach L, Elliott IM The present qualitative study explored how participants perceive their quality of life within the social domain 2years following epilepsy surgery. Semistructured, open-ended interviews were conducted with 27 participants (11-21years old), 2years following epilepsy surgery. Thirteen of the 27 participants were seizure free. Data were transcribed and coded inductively to allow for the identification of salient themes. Many of the seizure-free participants reported greater independence following surgery. However, most participants, irrespective of seizure status, continued to report some problems with peer relations and isolation. These findings suggest that self-perceived improvements in social function among seizure-free participants may req... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3232408 Wed, 27 Jan 2010 00:00:00 +0100 3232408 http://www.medworm.com/index.php?rid=3232407&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20116338%26dopt%3DAbstract Authors: Ma J, Boyce R, Leung LS Postictal movement dysfunction is a common symptom in patients with epilepsy. We investigated the involvement of opioid receptors in the nucleus accumbens (NAC) in amygdaloid kindling-induced postictal decrease in locomotion (PDL) in rats. Seizures were induced by daily electrical stimulation of the basolateral amygdala until four consecutive stage 5 seizures were elicited. Locomotion was quantified before and after infusion of an opioid receptor antagonist or saline into the NAC. Whereas PDL was induced after a stage 5 seizure in saline-infused rats, pre-infusion of the mu opioid receptor antagonist H-D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH(2) (CTAP, 5mug/1 muL/side) into the NAC prevented PDL. Pre-infusion of delta (naltrindole, 30mug/1 muL/side), kapp... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3232407 Wed, 27 Jan 2010 00:00:00 +0100 3232407 http://www.medworm.com/index.php?rid=3232406&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20116339%26dopt%3DAbstract Authors: Pramuka M, Hendrickson R, Van Cott AC After our study of a self-management intervention for epilepsy [1], we gathered data on Internet use and computer availability to assess the feasibility of computer-based interventions in a veteran population. Veterans were asked to complete an anonymous questionnaire that gathered information regarding seizures/epilepsy in addition to demographic data, Internet use, computer availability, and interest in distance education regarding epilepsy. Three hundred twenty-four VA neurology clinic patients completed the survey. One hundred twenty-six self-reported a medical diagnosis of epilepsy and constituted the epilepsy/seizure group. For this group of veterans, the need for remote/distance-based interventions was validated given the majority o... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3232406 Wed, 27 Jan 2010 00:00:00 +0100 3232406 http://www.medworm.com/index.php?rid=3208987&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20097137%26dopt%3DAbstract Authors: Mikati MA, Cornett KM PMID: 20097137 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3208987 Fri, 22 Jan 2010 00:00:00 +0100 3208987 http://www.medworm.com/index.php?rid=3208986&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20097615%26dopt%3DAbstract Authors: Alvarez V, Maeder P, Rossetti AO PMID: 20097615 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3208986 Fri, 22 Jan 2010 00:00:00 +0100 3208986 http://www.medworm.com/index.php?rid=3208989&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20096638%26dopt%3DAbstract Authors: Herzog AG, Farina EL, Drislane FW, Schomer DL, Smithson SD, Fowler KM, Dworetzky BA, Bromfield EB Hyposexuality is commonly associated with low bioavailable testosterone (BAT) and relative estradiol elevation in men with epilepsy. This prospective, randomized, double-blind trial compared the effects of depotestosterone+the aromatase inhibitor anastrozole (T-A) versus depotestosterone+placebo (T-P) on sexual function, hormone levels, mood, and seizure frequency in men with epilepsy. Forty men with focal epilepsy, hyposexuality, and hypogonadism were randomized 1:1 to two groups (T-A or T-P) for a 3-month treatment trial of depotestosterone+either anastrozole or matching placebo. Outcomes included both efficacy and safety measures. Normalization of sexual function (S-score) occu... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3208989 Wed, 20 Jan 2010 00:00:00 +0100 3208989 http://www.medworm.com/index.php?rid=3208988&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20096639%26dopt%3DAbstract Authors: Tran L, Goyal M Despite being underreported and underrecognized, child maltreatment is one of the most common causes of childhood morbidity and mortality. The epilepsy monitoring unit is especially amenable for identification of those at risk because it involves direct observation of behavior for days at a time. Although nonepileptic events may suggest psychosocial etiologies, we describe a case where the diagnosis of child maltreatment was made when no habitual events were recorded in the epilepsy monitoring unit. PMID: 20096639 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3208988 Wed, 20 Jan 2010 00:00:00 +0100 3208988 http://www.medworm.com/index.php?rid=3202061&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20093096%26dopt%3DAbstract Authors: Haag A, Barth S, Zibelius M, Hermsen A, Menzler K, Oertel WH, Hamer HM, Rosenow F, Knake S Memory for public events (PEs) was assessed as a marker of remote declarative memory in 36 patients with temporal lobe epilepsy (TLE) and compared with that of 19 patients with extra-TLE (ETLE), 17 patients with idiopathic generalized epilepsy (IGE), and 23 healthy volunteers. Verbal IQ, inventory-based evidence of depression, handedness, onset of illness, disease duration, and medication were obtained. Memory for PEs was reduced in all patient groups (TLE, P<0.0001; ETLE, P=0.009; IGE, P=0.008). The TLE group showed reduced memory for PEs compared with the other patients with epilepsy (P=0.001). A time gradient was observed, with worse memory for PEs of the 1990s and for PEs that occ... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3202061 Tue, 19 Jan 2010 00:00:00 +0100 3202061 http://www.medworm.com/index.php?rid=3202060&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20093097%26dopt%3DAbstract We describe the case of a 33-year-old man with complex partial seizures characterized by the feeling of being projected outside his body, including dissociation of "mind and self from body" (disembodiment), followed by vestibular vertigo due to right frontal lobe epilepsy caused by an oligodendroglioma. We distinguish the patient's ictal symptoms with respect to autoscopic phenomena (out-of-body experience, heautoscopy, autoscopic hallucinations) and vestibular phenomena of epileptic origin, and we discuss their neural origin with respect to vestibular and multisensory cortical mechanisms of bodily self-consciousness in temporoparietal and frontal cortex. PMID: 20093097 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3202060 Tue, 19 Jan 2010 00:00:00 +0100 3202060 http://www.medworm.com/index.php?rid=3202059&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20093098%26dopt%3DAbstract Authors: Li S, Wu J, Wang W, Jacoby A, de Boer H, Sander JW In the Chinese language there is no equivalent for the English word stigma; nevertheless, for many years, people with epilepsy in China have suffered from stigma. We suggest that the best Chinese word to use is (meaning "feeling of disgrace because of the condition-epilepsy or other disease"). Since the 1980s, studies on stigma associated with epilepsy have been conducted in China. These studies found that stigma is felt by about 89% of people with epilepsy and by about 76% of their family members. Here we report the results of a survey conducted in 2008 in a population who were treated with phenobarbital in 2002-2004 during the Demonstration Project of the Global Campaign Against Epilepsy (GCAE). The causes and manifestations... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3202059 Tue, 19 Jan 2010 00:00:00 +0100 3202059 http://www.medworm.com/index.php?rid=3202058&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20093099%26dopt%3DAbstract Authors: Kutluay E, Selwa L, Minecan D, Edwards J, Beydoun A Nonepileptic paroxysmal events in children are common, and may be more diverse in etiology than those seen in adults. We determined the types of nonepileptic events that are most prominent in the pediatric population, and stratified those events by age group. Ninety-four of 416 pediatric patients monitored during a 3-year period (23%) were found to have had nonepileptic events. Thirty-eight percent of these children were diagnosed with psychogenic nonepileptic seizures, and 72% of those were adolescents. In children younger than 5 years of age, behavioral events and parasomnias were the most common mimickers of epilepsy. Other events, including stereotyped movements and myoclonus, were also diagnosed. We suggest that children... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3202058 Tue, 19 Jan 2010 00:00:00 +0100 3202058 http://www.medworm.com/index.php?rid=3198356&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20089459%26dopt%3DAbstract Authors: Calabrò RS, Ferlazzo E, Domenico I, Bramanti P PMID: 20089459 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3198356 Mon, 18 Jan 2010 00:00:00 +0100 3198356 http://www.medworm.com/index.php?rid=3198355&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20089460%26dopt%3DAbstract Authors: Baslet G, Roiko A, Prensky E Multiple psychiatric and neurological factors in patients with psychogenic nonepileptic seizures (PNES) highlight the heterogeneity of this population. Forty-four individuals with PNES were evaluated and divided into groups based on psychiatric and neurological morbidity. Groups were then examined to determine how they differed in terms of clinical presentation, semiology, level of dysfunction, severity of psychopathology, and specific psychiatric and neurological conditions. Individuals with neurological morbidity more frequently displayed sound production during their events. Factors relevant to treatment planning such as psychiatric conditions, psychopathology severity, and dysfunction level did not differ between the group with neurological mor... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3198355 Mon, 18 Jan 2010 00:00:00 +0100 3198355 http://www.medworm.com/index.php?rid=3182598&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20080448%26dopt%3DAbstract Authors: Lally N, Spence W, McCusker C, Craig J, Morrow J Nonepileptic seizures (NES) provide a clinical challenge as the mechanisms involved remain uncertain. The present study compares 27 participants with confirmed NES presentations with 39 individuals with epileptic seizure (ES) presentations only, on indices of psychopathology, trauma history, dissociative propensity, and attachment style. Psychopathology and dissociation were found to be significantly elevated in the NES group compared with the ES group. No differences were found between groups in terms of trauma history and attachment style. However, trauma history did correlate significantly with psychopathology in the NES group but not in the ES group. Finally, whereas the relationship between psychological variables and seizu... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3182598 Fri, 15 Jan 2010 00:00:00 +0100 3182598 http://www.medworm.com/index.php?rid=3182599&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20079694%26dopt%3DAbstract Authors: Blake MG, Boccia MM, Carcaboso AM, Chiappetta DA, Höcht C, Krawczyk MC, Sosnik A, Baratti CM We previously reported that administration of a single dose of gabapentin (GBP) immediately after training improves memory of mice in an inhibitory avoidance task (IA), whereas GBP administered repeatedly for 7days impairs memory. This is in accordance with the observation that long-term clinical treatment with GBP may be associated with adverse cognitive side effects. In the present work we used a GBP-loaded poly(epsilon-caprolactone) implant, allowing controlled release of the drug and maintenance of constant plasma levels over 1week. When GBP-loaded implants were inserted subcutaneously into mice, immediately after training in the IA task, memory consolidation was enhanced. Mor... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3182599 Wed, 13 Jan 2010 00:00:00 +0100 3182599 http://www.medworm.com/index.php?rid=3179892&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20075009%26dopt%3DAbstract In conclusion, anxiety disorders are frequent in patients with refractory focal epilepsy, and clinicians should carefully examine their patients with this important comorbidity in mind. PMID: 20075009 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3179892 Tue, 12 Jan 2010 00:00:00 +0100 3179892 http://www.medworm.com/index.php?rid=3179891&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20075010%26dopt%3DAbstract CONCLUSIONS: A problem noted is that IAT procedures vary from center to center and that IAT may increase the risk for individual patients because of differences between IAT and other CA interventions. PMID: 20075010 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3179891 Tue, 12 Jan 2010 00:00:00 +0100 3179891 http://www.medworm.com/index.php?rid=3179890&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20075011%26dopt%3DAbstract Authors: Hughes JR The goal of this article is to review Savant Syndrome, characterized by outstanding islands of mental ability in otherwise handicapped individuals. Two forms exist: the congenital form and the acquired form. Among the many examples of the congenital form are the calendar calculators, who can quickly provide the day of the week for any date in the past; the musical savants, who have perfect pitch; and the hyperlexics, who (in one case) can read a page in 8s and recall the text later at a 99% level. Other types of talents and artistic skills involving three-dimensional drawing, map memory, poetry, painting, and sculpturing are also observed. One savant could recite without error the value of Pi to 22,514 places. Persons with the acquired form develop outstanding skills... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3179890 Tue, 12 Jan 2010 00:00:00 +0100 3179890 http://www.medworm.com/index.php?rid=3176259&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20071244%26dopt%3DAbstract Authors: Zangaladze A, Asadi-Pooya AA, Ashkenazi A, Sperling MR Familial hemiplegic migraine (FHM) is a clinically and genetically heterogeneous disease most commonly linked to CACNA1A gene mutation. Epilepsy rarely occurs in FHM and is seen predominantly with specific CACNA1A gene mutations. Here we report a sporadic case of FHM1 linked to S218L CACNA1A gene mutation with the triad of prolonged hemiplegic migraine, cerebellar symptoms, and epileptic seizures. Epilepsy in this syndrome follows the pattern of isolated unprovoked seizures occurring only during childhood and hemiplegic migraine-provoked seizures occurring during adulthood. Clinical and electrographic status epilepticus can occur during prolonged migraine attacks. We suggest that patients with seizures, ataxia, and hemiple... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3176259 Mon, 11 Jan 2010 00:00:00 +0100 3176259 http://www.medworm.com/index.php?rid=3167817&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20064748%26dopt%3DAbstract CONCLUSIONS: Ictal flatulence is a rare manifestation of autonomic seizures and a localizing sign for temporal or/and insular lobe epilepsies. In general, ictal flatulence seems to have no lateralizing value. PMID: 20064748 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3167817 Sat, 09 Jan 2010 00:00:00 +0100 3167817 http://www.medworm.com/index.php?rid=3167816&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20064749%26dopt%3DAbstract We describe a patient presenting with a first generalized convulsion after alcohol consumption, in whom the early postictal finding of a rapidly regressive cortical visual impairment suggested the presence of a posterior reversible encephalopathy. This was confirmed radiologically, and probably represented the key factor in the seizure etiology. PMID: 20064749 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3167816 Sat, 09 Jan 2010 00:00:00 +0100 3167816 http://www.medworm.com/index.php?rid=3167818&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20061185%26dopt%3DAbstract Authors: Locke DE, Kirlin KA, Thomas ML, Osborne D, Hurst DF, Drazkowski JF, Sirven JI, Noe KH The Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF) is a restructuring of the MMPI-2 that has improved the psychometric characteristics of the test. The primary aim of this study was to provide diagnostic utility data on the MMPI-2-RF in an epilepsy monitoring unit population (N=429). Mean comparisons revealed group differences on Validity Scales Fs and FBS-r; Restructured Clinical Scales RC1 and RC3; and Somatic Scales MLS, GIC, HPC, and NUC. Diagnostic utility data are provided for those scales with the largest effect sizes: RC1, FBS-r, and NUC. On RC1, sensitivity was 76% and specificity was 60%, similar to values found when applying published decision rules to ... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3167818 Fri, 08 Jan 2010 00:00:00 +0100 3167818 http://www.medworm.com/index.php?rid=3167819&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20060785%26dopt%3DAbstract CONCLUSION: The majority of patients with partial seizures recognize triggers of seizure onset. In addition, more than one-third believe they can effectively self-terminate their partial-onset seizures. Lying down, resting, and taking extra medication were the most common techniques instituted by patients. Correlating clinical symptoms at seizure onset with termination may help improve the sensitivity in seizure prediction. PMID: 20060785 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3167819 Thu, 07 Jan 2010 00:00:00 +0100 3167819 http://www.medworm.com/index.php?rid=3143347&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20045666%26dopt%3DAbstract In conclusion, during diagnostic video/EEG telemetry, most patients who experience PNES or ES have diagnostic, typical events within 2days. Although time to initial event after electrode placement does not differ between diagnoses, events prior to or during placement are most likely PNES and events at night are most likely ES. PMID: 20045666 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3143347 Thu, 31 Dec 2009 00:00:00 +0100 3143347 http://www.medworm.com/index.php?rid=3143346&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20045667%26dopt%3DAbstract Authors: Chen DK, Izadyar S Various psychiatric disorders can contribute to psychogenic nonepileptic events (PNEEs), including posttraumatic stress disorder (PTSD). We hypothesize that among patients with PNEEs and PTSD, the nature of the traumatic experience leading to PTSD has an association with the clinical manifestations of PNEEs. We found that the presence of PTSD, in general, did not demonstrate significant association with any particular PNEE semiology in a veterans population. However, 11 of 12 (91.7%) subjects with PNEEs and specifically combat-related PTSD showed significant predilection for hypomotor or nonmotor PNEEs, as compared to 5 of 12 (41.7%) subjects with PNEE and non-combat-related PTSD (P=0.027). Between these two subgroups of subjects with PTSD, there were no sta... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3143346 Thu, 31 Dec 2009 00:00:00 +0100 3143346 http://www.medworm.com/index.php?rid=3143348&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20045383%26dopt%3DAbstract We report on LEV therapy in 32 children (mean age: 10.6 years, range: 4-14) with RE or variants like atypical benign idiopathic partial epilepsy of childhood (ABIPEC), Landau-Kleffner syndrome (LKS), and continuous spikes and waves during sleep (CSWS) and in children with benign idiopathic focal epileptiform discharges of childhood (BIFEDC). Cognitive and behavioral problems, not seizures, may be related to the pathological EEG. Patients with a reduction in seizure frequency >50% and/or reduction in BIFEDC >90% 3 months after having started LEV therapy were defined as responders. The average dose of LEV was 39mg/kg body wt per day; LEV was given in monotherapy to 31.3% of the patients. Overall, 20 of 32 patients (62.5%) did benefit: 12 of 24 patients had a >50% reduction in seizur... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3143348 Wed, 30 Dec 2009 00:00:00 +0100 3143348 http://www.medworm.com/index.php?rid=3136806&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20044314%26dopt%3DAbstract Authors: Schelter B, Feldwisch-Drentrup H, Timmer J, Gotman J, Schulze-Bonhage A A reliable algorithm for the timely prediction of epileptic seizures would be a milestone in epilepsy research. Prediction performances have so far been determined using retrospective data assessment, leaving open the question as to whether they prove statistically significant and clinically useful under prospective conditions. To this aim, a Seizure Prediction Competition has been set up. Here, the background and the details of this competition are described. PMID: 20044314 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3136806 Tue, 29 Dec 2009 00:00:00 +0100 3136806 http://www.medworm.com/index.php?rid=3136809&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20042370%26dopt%3DAbstract Authors: Ekinci O, Arman AR, Işık U, Bez Y, Berkem M Our aim was to examine the characteristics of EEG findings and epilepsy in autistic spectrum disorders (ASD) and the associated clinical and familial risk factors. Fifty-seven children (86% male) with ASD, mean age 82+/-36.2months, were included in the study. Thirty-nine (68.4%) children had the diagnosis of autism, 15 (26.3%) had Pervasive Developmental Disorder Not Otherwise Specified, and 3 (5.3%) had high-functioning autism. One hour of sleep and/or awake EEG recordings was obtained for each child. All patients were evaluated with respect to clinical and familial characteristics and with the Childhood Autism Rating Scale, the Autism Behavior Checklist, and the Aberrant Behavior Checklist. The frequency of interictal e... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3136809 Mon, 28 Dec 2009 00:00:00 +0100 3136809 http://www.medworm.com/index.php?rid=3136808&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20042371%26dopt%3DAbstract Authors: Scorza FA, Cavalheiro EA, Arida RM, Hughes JR PMID: 20042371 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3136808 Mon, 28 Dec 2009 00:00:00 +0100 3136808 http://www.medworm.com/index.php?rid=3136807&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20042372%26dopt%3DAbstract Authors: Lee H, Lee SK, Chung CK, Yun SN, Choi-Kwon S We investigated familiarity with, knowledge of, and attitudes toward epilepsy among teachers in elementary schools in Korea, where there is profound prejudice against epilepsy. Most of the teachers thought that epilepsy is a genetic disease. They agreed that children with epilepsy (CWE) should attend regular classes (although with some restriction of school activities) because their academic achievement would be comparable to that of children without epilepsy. However, half of the teachers opposed having CWE in their own classes because they feared a child having a seizure during class and they felt they lacked knowledge of first-aid for seizures. Those teachers who had inaccurate clinical knowledge of epilepsy also demonstrated neg... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3136807 Mon, 28 Dec 2009 00:00:00 +0100 3136807 http://www.medworm.com/index.php?rid=3110318&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20022813%26dopt%3DAbstract In this study, personality differences between patients with right temporal (n=23), left temporal (n=21), and extratemporal (n=24) epilepsy were investigated using the NEO Personality Inventory-Revised (NEO-PI-R). No statistically significant differences were found on any of the NEO-PI-R domains or facet trait scales. There were also no significant differences between groups on the Minnesota Multiphasic Personality Inventory 2 (MMPI-2), a measure of psychopathology. However, mild elevations were seen in all groups on clinical scales related to physical symptoms, health concern, and depression. These data suggest there are no consistent personality or psychopathology differences, as measured by the NEO-PI-R and the MMPI-2, between patients with left temporal, right temporal, and extratempor... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3110318 Fri, 18 Dec 2009 00:00:00 +0100 3110318 http://www.medworm.com/index.php?rid=3101624&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20006556%26dopt%3DAbstract This study suggests that SHRs may be useful in modeling some aspects (particularly hypertension-related diurnal rhythm disturbance) of behavior associated with epilepsy. PMID: 20006556 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3101624 Fri, 11 Dec 2009 00:00:00 +0100 3101624 http://www.medworm.com/index.php?rid=3101628&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20004148%26dopt%3DAbstract Authors: Carrion MJ, Nunes ML, Martinez JV, Portuguez MW, da Costa JC The aim of the study was to evaluate excessive daytime sleepiness and subjective sleep quality in patients who undergo epilepsy surgery for treatment of refractory partial seizures. Forty-eight patients were enrolled in this research study. All of them were evaluated 2days before and 3months after the surgery. Two questionnaires were used to assess daytime sleepiness (Epworth Sleepiness Scale [ESS]) and sleep quality (Pittsburgh Sleep Quality Index [PSQI]). Global PSQI was high (mean=5.65 SD=3.71) before the surgical procedure (P<0.001). PSQI evaluation revealed higher and statistically significant scores in three components as well as in the global score, when analyzed by predominance of daytime or nocturnal seiz... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3101628 Tue, 08 Dec 2009 00:00:00 +0100 3101628 http://www.medworm.com/index.php?rid=3101627&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20004618%26dopt%3DAbstract Authors: Osorio I PMID: 20004618 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3101627 Tue, 08 Dec 2009 00:00:00 +0100 3101627 http://www.medworm.com/index.php?rid=3101626&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20004619%26dopt%3DAbstract Authors: Canuet L, Ishii R, Iwase M, Ikezawa K, Kurimoto R, Takahashi H, Currais A, Azechi M, Nakahachi T, Hashimoto R, Takeda M Working memory (WM) deficits are considered a core cognitive dysfunction in schizophrenia. To determine cognitive abnormalities in chronic interictal psychosis (CIP), and to assess whether these abnormalities are distinguishable from those seen in schizophrenia in terms of WM deficits, we used magnetoencephalography during a WM task performed by patients with CIP, nonpsychotic epilepsy, and schizophrenia and by healthy subjects. Multiple Source Beamformer and Brain-Voyager were used for analysis. In both patients with CIP and those with schizophrenia, we found dorsolateral prefrontal hyperactivation and left inferior temporal hypoactivation, as indicated by a... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3101626 Tue, 08 Dec 2009 00:00:00 +0100 3101626 http://www.medworm.com/index.php?rid=3101625&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20004620%26dopt%3DAbstract Authors: Mikati MA, Kurdi R, El-Khoury Z, Rahi A, Raad W Our aim was to investigate the long term effectiveness of intravenous immunoglobulin (IVIG) against intractable childhood epilepsy in the era of new antiepileptics and to determine the predictors of a favorable response in a prospective open-label add-on study. Of thirty-seven 9.9+/-0.9-year-old patients (11 with partial seizures, 26 with generalized seizures of whom 9 had West syndrome and 17 Lennox-Gastaut syndrome) followed for 15+/-3months, 43% had a >50% decrease in seizures (including 15% seizure free, 229+/-58 compared with 104+/-3 seizures/month, P=0.035: generalized 246+/-318 to 117+/-200, P=0.025, partial 191+/-437 to 72+/-179, P>0.05; power=0.2). Males were more likely to respond than females (P=0.011, odds ratio... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3101625 Tue, 08 Dec 2009 00:00:00 +0100 3101625 http://www.medworm.com/index.php?rid=3070649&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19969506%26dopt%3DAbstract This study investigated the interplay of these effects with neurogenesis and brain-derived neurotrophic factor (BDNF). The results clearly showed a positive effect of long-term omega-3 fatty acid supplementation on brain plasticity in animals with epilepsy. Enhanced hippocampal neurogenesis and BDNF levels and preservation of interneurons expressing parvalbumin were observed. Parvalbumin-positive cells were identified as surviving instead of newly formed cells. Additional investigations are needed to determine the electrophysiological properties of the newly formed cells and to clarify whether the effects of omega-3 fatty acids on brain plasticity are accompanied by functional gain in animals with epilepsy. PMID: 19969506 [PubMed - as supplied by publisher] (Source: Epilepsy and Behavi... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3070649 Sat, 05 Dec 2009 00:00:00 +0100 3070649 http://www.medworm.com/index.php?rid=3070650&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19963440%26dopt%3DAbstract Authors: Magiorkinis E, Sidiropoulou K, Diamantis A The purpose of this article is to highlight the hallmarks of epilepsy as a disease and symptom during antiquity and especially during Ancient Greece and Rome. A thorough study of texts, medical books, and reports along with a review of the available literature in PubMed was undertaken. Observations on epilepsy date back to the medical texts of the Assyrians and Babylonians, almost 2000 years B.C. Considered initially as a divine malady or demonic possession, epilepsy was demythologized by the Father of Medicine, Hippocrates, who was the first to set in dispute its divine origin. Physicians in the early post-Hippocratic era did not make any important contribution regarding the mechanisms of epileptic convulsions, but contributed mainly... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3070650 Fri, 04 Dec 2009 00:00:00 +0100 3070650 http://www.medworm.com/index.php?rid=3070651&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19962944%26dopt%3DAbstract Authors: Arida RM, Vieira DE, Cavalheiro EA, Scorza FA PMID: 19962944 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3070651 Thu, 03 Dec 2009 00:00:00 +0100 3070651 http://www.medworm.com/index.php?rid=3053043&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19948427%26dopt%3DAbstract Authors: Salpekar JA, Plioplys S, Siddarth P, Bursch B, Shaw RJ, Asato MR, Lafrance WC, Weisbrot DM, Dunn DW, Austin JK, Olson DM, Caplan R The goal of this study was to identify assessment tools and associated behavioral domains that differentiate children with psychogenic nonepileptic seizures (PNES) from those with epilepsy. A sample of 24 children with PNES (mean age 14.0 years, 14 female), 24 children with epilepsy (mean age 13.6 years, 13 female), and their parents were recruited from five epilepsy centers in the United States. Participants completed a battery of behavioral questionnaires including somatization, anxiety, and functional disability symptoms. Children with PNES had significantly higher scores on the Childhood Somatization and Functional Disability Inventories, and t... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3053043 Sat, 28 Nov 2009 00:00:00 +0100 3053043 http://www.medworm.com/index.php?rid=3030038&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19932640%26dopt%3DAbstract CONCLUSION: Traditional healers constituted the focus group studied so far in Cameroon that is most familiar with epilepsy. Although they still have some negative practices, the attitudes of traditional healers toward PWE in Batibo Health District are satisfactory, compared with those of the general public and students in the same community. These findings provide evidence for the first time in Cameroon suggesting that collaboration between the modern and traditional health systems with the view of bridging the epilepsy treatment gap is possible. There is a need to train traditional healers in epilepsy care in our context. PMID: 19932640 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3030038 Fri, 20 Nov 2009 00:00:00 +0100 3030038 http://www.medworm.com/index.php?rid=3030037&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19932641%26dopt%3DAbstract Authors: Jaseja H PMID: 19932641 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3030037 Fri, 20 Nov 2009 00:00:00 +0100 3030037 http://www.medworm.com/index.php?rid=3030039&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19932061%26dopt%3DAbstract Authors: Jaseja H Meditation is a mental exercise practiced widely as an antistress measure and in the belief that it possesses remedial efficacy for a number of medical ailments, especially neurological disorders. Further, there is a general belief that meditation is an absolutely safe practice devoid of any harmful effects. However, with the advent of neuroimaging techniques, the possibility of adverse effects has been raised in recent times. One such issue that has been debated is the potential epileptogenic versus antiepileptic influence exerted by meditation. This brief article attempts to study the potential role of meditation-induced EEG fast oscillations in the predisposition to seizures in meditation practitioners with epilepsy. PMID: 19932061 [PubMed - as supplied by publ... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3030039 Thu, 19 Nov 2009 00:00:00 +0100 3030039 http://www.medworm.com/index.php?rid=3030041&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19931492%26dopt%3DAbstract Authors: Hermann B, Meador KJ, Gaillard WD, Cramer JA Cognitive problems in persons with epilepsy manifest over a lifetime; however, whether abnormal cognition in an individual with epilepsy is a result of comorbid brain substrate, the epilepsy itself or its underlying etiology, the antiepileptic agents used to control it, or a combination of these and other factors remains controversial. There is a continuing need for improved therapies to control seizures and reduce the incidence of adverse events, especially those involving the central nervous system that compromise attention, intelligence, language skills, verbal and nonverbal memory, executive function, and psychomotor speeds. Although cognitive decline typically occurs among patients with more severe epilepsy, physicians must jud... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3030041 Wed, 18 Nov 2009 00:00:00 +0100 3030041 http://www.medworm.com/index.php?rid=3017354&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19926525%26dopt%3DAbstract Authors: Sunderam S, Gluckman B, Reato D, Bikson M Electrical stimulation is emerging as a viable alternative for patients with epilepsy whose seizures are not alleviated by drugs or surgery. Its attractions are temporal and spatial specificity of action, flexibility of waveform parameters and timing, and the perception that its effects are reversible unlike resective surgery. However, despite significant advances in our understanding of mechanisms of neural electrical stimulation, clinical electrotherapy for seizures relies heavily on empirical tuning of parameters and protocols. We highlight concurrent treatment goals with potentially conflicting design constraints that must be resolved when formulating rational strategies for epilepsy electrotherapy, namely, seizure reduction versus... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3017354 Mon, 16 Nov 2009 00:00:00 +0100 3017354 http://www.medworm.com/index.php?rid=3013269&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19919904%26dopt%3DAbstract Authors: Guekht AB, Korczyn AD, Bondareva IB, Gusev EI This meta-analysis of published, randomized, controlled trials (RCTs) of antiepileptic drugs in adults with focal drug-resistant epilepsy was performed to estimate a mean placebo effect, to evaluate variability in placebo response rates, to investigate associations between placebo effect rates and study characteristics, and to determine whether there were changes in placebo response rates over recent years in RCTs (so-called "placebo drift"). One hundred ninety-eight potentially appropriate studies were identified after MEDLINE search and carefully reviewed. Twenty-seven RCTs (with 5662 randomized patients, including 1887 patients in placebo arms) were included in the meta-analysis. A random effects meta-analytic model estimated th... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3013269 Mon, 16 Nov 2009 00:00:00 +0100 3013269 http://www.medworm.com/index.php?rid=3004931&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19914875%26dopt%3DAbstract This article, originating from a case report, shows how some Christian painting alludes to renaissance after a seizure and to the parallelism between the patient with epilepsy and the destiny of Christ. Special attention is paid to Raphael's, in this respect particularly complex work, The Transfiguration. PMID: 19914875 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3004931 Fri, 13 Nov 2009 00:00:00 +0100 3004931 http://www.medworm.com/index.php?rid=3004932&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19914140%26dopt%3DAbstract Conclusion: Executive performance has a major impact on suicide risk and suicide attempts in patients with temporal lobe epilepsy. PMID: 19914140 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3004932 Thu, 12 Nov 2009 00:00:00 +0100 3004932 http://www.medworm.com/index.php?rid=3004935&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19913461%26dopt%3DAbstract Authors: Saadeldin IY A 9-year 2-month-old Saudi boy of normal intelligence was brought to a pediatric neurology clinic because of episodes of abnormal behavior associated with disorientation and confusion and postictal amnesia. Video/EEG evaluation unexpectedly documented the presence of fixation-off sensitivity. PMID: 19913461 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3004935 Wed, 11 Nov 2009 00:00:00 +0100 3004935 http://www.medworm.com/index.php?rid=3004934&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19913462%26dopt%3DAbstract We examined data from a sample of older veterans (>65years) receiving care from the Veterans Health Administration during fiscal year 2000. We compared individuals with new-onset epilepsy and individuals without epilepsy to examine the extent to which psychiatric disorders were associated with new-onset epilepsy; this analysis controlled for demographic and premorbid neurological risk factors previously associated with new-onset epilepsy. Premorbid psychiatric conditions occurred at higher rates in the epilepsy versus nonepilepsy groups, foremost including depression (17% vs 12%), anxiety (12% vs 8%), psychosis (12% vs 5%), and substance abuse (8% vs 4%). However, in the final model, only psychosis (OR=1.4, CI 1.2-1.6) was significantly associated with epilepsy when controlling for neur... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3004934 Wed, 11 Nov 2009 00:00:00 +0100 3004934 http://www.medworm.com/index.php?rid=3004933&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19913463%26dopt%3DAbstract Authors: Bozkaya IO, Arhan E, Serdaroglu A, Soysal AS, Ozkan S, Gucuyener K Epilepsy is one of the most common serious chronic brain disorders of childhood and carries a strong social stigma. It has been generally accepted that educational programs can be beneficial in reducing the stigma of a number of chronic diseases such as epilepsy. In this article, we describe the first Turkish survey of primary school students' knowledge of and attitudes toward epilepsy and the effect of an epilepsy education program on the understanding of epilepsy in schoolchildren attending three different upper-middle schools in the city of Ankara. The epilepsy education program was found to be associated with a significant increase in knowledge of and positive attitudes toward epilepsy. In addition, student... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3004933 Wed, 11 Nov 2009 00:00:00 +0100 3004933 http://www.medworm.com/index.php?rid=3004939&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19910259%26dopt%3DAbstract CONCLUSION: This pragmatic procedure suggests that the network could be suitable for managing convulsive epilepsy in resource-poor regions. Such a network could depend on existing primary health services to ensure its sustainability. PMID: 19910259 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3004939 Tue, 10 Nov 2009 00:00:00 +0100 3004939 http://www.medworm.com/index.php?rid=3004938&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19910260%26dopt%3DAbstract Authors: Benish SM, Cascino GD, Warner ME, Worrell GA, Wass CT General anesthesia may be required for particular diagnostic and therapeutic procedures in patients with seizure disorders. There is concern regarding the safety of anesthetic drugs in these individuals because of the reported proconvulsant effect of selected medications. Potentially, general anesthesia may be associated with perioperative seizures or increased adverse effects in people with epilepsy. The rationale for the present study was to evaluate the outcome of general anesthesia in a population-based cohort with seizure disorders undergoing interventions that were unlikely to alter the seizure tendency, for example, magnetic resonance imaging study. Seizures were observed in only 6 of 297 (2%) anesthetic procedures, ... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3004938 Tue, 10 Nov 2009 00:00:00 +0100 3004938 http://www.medworm.com/index.php?rid=3004937&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19910261%26dopt%3DAbstract Authors: Prus N, Grant AC We assessed beliefs about epilepsy and brain surgery and the use of alternative epilepsy treatments in a culturally diverse population of people with epilepsy (PWE). Data were obtained from a structured questionnaire administered to 109 PWE treated at a single epilepsy center. Patients were born in 17 countries on five continents. Most patients identified culturally with the Caribbean (41%), United States (39%), or Latin America (9%). Sixty-nine percent of patients endorsed at least one of five stigma-related questions, and 77% used at least one alternative epilepsy treatment. Brain surgery was rated as having a mean dangerousness of 8.3 (on a scale of 1 to 10) among the 94 patients with no history of neurosurgery. In addition, 51% of these patients would not ... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3004937 Tue, 10 Nov 2009 00:00:00 +0100 3004937 http://www.medworm.com/index.php?rid=3004936&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19910262%26dopt%3DAbstract This study yielded encouraging results. However, further studies are needed to confirm these findings and gain a better understanding of the contribution of French public knowledge to the causative factors generating stigma in France. PMID: 19910262 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=3004936 Tue, 10 Nov 2009 00:00:00 +0100 3004936 http://www.medworm.com/index.php?rid=2989512&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19906565%26dopt%3DAbstract Authors: Belcastro V, Mattucci E, Rossi A, Calabresi P, Tambasco N PMID: 19906565 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2989512 Mon, 09 Nov 2009 00:00:00 +0100 2989512 http://www.medworm.com/index.php?rid=2981615&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19896907%26dopt%3DAbstract Authors: Hughes JR This publication, by reviewing 1300 studies published on autism in 2008, represents an update on this topic. Results include possible parental influences, maternal conditions, and studies on genes and chromosomes. Possible etiological factors involve the "extreme male brain," defects in the mirror neuron system, vaccines, underconnectivity, disorders of central coherence, and many other more specific etiologies. Assessments or tests for autism are also reviewed. Characteristics of autistic individuals include repetitive behavior, language disorders, sleep disturbances, social problems, joint attention disorders, seizures, allergic reactions, and various behavioral changes. Cognitive changes involve IQ, reasoning, and verbal and language disorders. The savant syndrome... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2981615 Thu, 05 Nov 2009 00:00:00 +0100 2981615 http://www.medworm.com/index.php?rid=2971050&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19892603%26dopt%3DAbstract CONCLUSION: Children prenatally exposed to valproate demonstrate impaired fluency and originality compared with children exposed to lamotrigine and carbamazepine. PMID: 19892603 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2971050 Tue, 03 Nov 2009 00:00:00 +0100 2971050 http://www.medworm.com/index.php?rid=2955668&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19884045%26dopt%3DAbstract We describe the case of a 48-year-old man who presented with complex partial status epilepticus with visual seizures in the context of ketotic hyperglycemia. The EEG revealed a temporal epileptogenic focus and alterations were apparent on MRI in the acute phase and 4months later. Very few cases of seizures in ketotic patients have been reported because ketone bodies have a protective effect against epilepsy. Seizures in hyperglycemia tend to be partial, and the only reports of visual seizures were due to occipital foci. Neuroradiological alterations have been reported in epileptic seizures, although usually in generalized seizures. The clinical, electrical, and imaging characteristics of this case are interesting and suggest that partial seizures can also cause long-term neuronal damage. ... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2955668 Sat, 31 Oct 2009 00:00:00 +0100 2955668 http://www.medworm.com/index.php?rid=2955667&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19884046%26dopt%3DAbstract Authors: Larner AJ The author Margiad Evans (1909-1958), a celebrated Anglo-Welsh writer of the 1930s and 1940s, developed epilepsy in 1950, and subsequently wrote accounts of her experiences of seizures, their diagnosis, and their management. These documents are among the first patient accounts of epilepsy, and remain of value today, not least because they prefigure ongoing problems in epilepsy management such as pregnancy and the adverse effects of antiepileptic drugs. They also give some insights into the consequences of epilepsy for a creative writer. PMID: 19884046 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2955667 Sat, 31 Oct 2009 00:00:00 +0100 2955667 http://www.medworm.com/index.php?rid=2955669&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19880353%26dopt%3DAbstract The objectives of this study were to translate into Serbian the Health-Related Quality of Life Measure for Children with Epilepsy (CHEQOL-25) and to provide preliminary data on its measurement properties. Translation, cultural adaptation, and pretesting were performed first, followed by evaluation of several reliability aspects of this version administered to 50 children with epilepsy and their parents. The mean scores of the CHEQOL-25 subscales ranged from 12.2 to 14.4 for children and from 12.4 to 15 for parents (possible range: 5-20). The internal consistency coefficients of the subscales ranged from 0.11 to 0.87. Between the children's and parents' reports, there was a moderate level of agreement (0.43-0.57). It was concluded that the Serbian version is a feasible measure, all subscale... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2955669 Fri, 30 Oct 2009 00:00:00 +0100 2955669 http://www.medworm.com/index.php?rid=2955671&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19879810%26dopt%3DAbstract CONCLUSION: The present results provide evidence for a statistical bidirectionality of the relationship between depressive symptoms and postoperative seizure status in a mixed sample of patients with TLE and FLE. Possible reasons for this bidirectional association include an underlying common pathology in both depression and epilepsy, for example, structural changes or functional alterations in neurotransmitter systems. PMID: 19879810 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2955671 Thu, 29 Oct 2009 00:00:00 +0100 2955671 http://www.medworm.com/index.php?rid=2955670&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19879811%26dopt%3DAbstract This article explores the idea that epileptic activity may interfere with psychosocial functions and development in children. In an adult population with epilepsy, left hemispheric seizure focus predicts worse psychosocial functioning. The developmental aspects of these disturbances require further studies. We studied self-report measures of cognitive (locus of control) and emotional (Beck Youth Inventories of Emotional and Social Impairment) functions in 30 children with partial epilepsy (6-15years) and 60 healthy matched controls. Multivariate statistics revealed significant lateralization effects, with left-sided foci (n=15) leading to more external locus of control. Opposite to adults, the children with right hemispheric foci (n=15) exhibited more emotional impairments (anger, disrupti... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2955670 Thu, 29 Oct 2009 00:00:00 +0100 2955670 http://www.medworm.com/index.php?rid=2955673&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19879196%26dopt%3DAbstract Authors: Benbadis SR PMID: 19879196 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2955673 Wed, 28 Oct 2009 00:00:00 +0100 2955673 http://www.medworm.com/index.php?rid=2955672&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19879197%26dopt%3DAbstract Authors: Danielsson J, Petermann F Recent developments in research on cognitive abilities in benign rolandic epilepsy of childhood with centrotemporal spikes have led to interest in the following domains: language, memory, executive, motor, and visual-constructive functions. As previous studies have investigated the cognitive development of mainly school-aged children, this study focuses on preschool and elementary school children. Twenty-five children affected by benign rolandic epilepsy/rolandic discharges and 25 healthy children matched for age and sex were enrolled in this retrospective study. The mean IQ scores were 94.76 for children with epilepsy and 99.3 for control children. For the children with benign rolandic epilepsy, cognitive testing revealed increased verbal and nonverb... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2955672 Wed, 28 Oct 2009 00:00:00 +0100 2955672 http://www.medworm.com/index.php?rid=2947211&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19864187%26dopt%3DAbstract Authors: Brown I, Sheeran P, Reuber M Suboptimal adherence to antiepileptic drug (AED) treatment is commonplace, and increases the risk of status epilepticus and sudden unexplained death in epilepsy. This randomized controlled trial was designed to demonstrate whether an implementation intention intervention involving the completion of a simple self-administered questionnaire linking the intention of taking medication with a particular time, place, and other activity can improve AED treatment schedule adherence. Of the 81 patients with epilepsy who were randomized, 69 completed a 1-month monitoring period with an objective measure of tablet taking (electronic registration of pill bottle openings, Medication Event Monitoring System [MEMS]). Intervention participants showed improved adhe... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2947211 Mon, 26 Oct 2009 00:00:00 +0100 2947211 http://www.medworm.com/index.php?rid=2931699&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19854108%26dopt%3DAbstract CONCLUSIONS: These findings suggest that IEDs and NAA/(Cho+Cr) ratios reflecting neural metabolism are closely related to verbal memory function in mesial temporal sclerosis. Higher interictal activity on the EEG was associated with a decline in total NAA in contralateral mesial temporal structures. PMID: 19854108 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2931699 Thu, 22 Oct 2009 00:00:00 +0100 2931699 http://www.medworm.com/index.php?rid=2931698&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19854109%26dopt%3DAbstract This study shows that in addition to factors related to the chronic nature of epilepsy and antiepileptic drug use, hippocampal sclerosis may cause autonomic dysfunction during the interictal period in persons with temporal lobe epilepsy. PMID: 19854109 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2931698 Thu, 22 Oct 2009 00:00:00 +0100 2931698 http://www.medworm.com/index.php?rid=2931697&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19854110%26dopt%3DAbstract Commentary on Bonnier P. L'aschématie. Rev Neurol (Paris) 1905;13:605-9. Epilepsy Behav. 2009 Oct 22; Authors: Vallar G, Rode G PMID: 19854110 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2931697 Thu, 22 Oct 2009 00:00:00 +0100 2931697 http://www.medworm.com/index.php?rid=2931696&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19854111%26dopt%3DAbstract Authors: Charyton C, Elliott JO, Lu B, Moore JL Previous studies have found that psychosocial factors have the greatest impact on health-related quality of life (HRQOL). Social support can buffer the negative impact of stressful events and chronic health conditions. To date, no population studies have examined the association between social support and epilepsy. In the 2003 California Health Interview Survey (CHIS), four questions were used to assess social support. A set of survey weight-adjusted logistic regression analyses were conducted with self-rated health status as the outcome. In those regression models, we examined the effect of epilepsy status, social support, and their interactions, after controlling for demographics. Analyses examining the interaction between epilepsy and ... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2931696 Thu, 22 Oct 2009 00:00:00 +0100 2931696 http://www.medworm.com/index.php?rid=2931701&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19853516%26dopt%3DAbstract Authors: Scorza FA, Cysneiros RM, Terra VC, Arida RM, Scorza CA, Cavalheiro EA In 1991, a mummy frozen in ice was found by climbers in the Tyrolean Alps. Otzi the Iceman has since been studied in the light of evolutionary explanations for diseases. This year, which marks Charles Darwin's 200th birthday and the 150th anniversary of his publication On the Origin of Species, should re-ignite discussion of the importance of the correlation between nutritional diet and diseases. Epilepsy is one of the commonest diseases in the world. Individuals with epilepsy are at higher risk of death than the general population, and sudden unexpected death (SUDEP) is the most important direct epilepsy-related cause of death. A number of factors may influence the risk for SUDEP. Along these lines, several... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2931701 Wed, 21 Oct 2009 00:00:00 +0100 2931701 http://www.medworm.com/index.php?rid=2931700&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19853517%26dopt%3DAbstract Authors: Specht U, Thorbecke R In the absence of evidence-based regulations on the driving ability of patients with psychogenic nonepileptic seizures (PNES), we asked 41 German epileptologists via e-mail for their recommendations on driving with PNES. This survey was modeled on an earlier study by Benbadis et al. [11] in the United States and was compared with it. Thirty-four (82.9%) epileptologists responded. Three responses were possible: (A) same restrictions as stipulated for patients with epilepsy, answered by 11 epileptologists (32.4%); (B) no restrictions at all, which no German expert gave as an answer (0%); (C) decision on an individual basis, answered by 23 experts (67.6%). The divergent approaches reflect the poor data on motor vehicle accidents of patients with PNES and the... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2931700 Wed, 21 Oct 2009 00:00:00 +0100 2931700 http://www.medworm.com/index.php?rid=2921123&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19846345%26dopt%3DAbstract We describe the case of a 45-year-old woman with frequent simple partial seizures consisting mainly of autonomic manifestations including flatulence. The ictal onset and interictal EEG epileptiform abnormalities were localized to the right frontotemporal region. This localization was supported by structural brain imaging showing recurrence of a right frontotemporal oligodendroglioma with involvement of the insula. We therefore suggest that ictal flatulence is one of several autonomic and gastrointestinal symptoms and signs that may be used clinically in lateralizing to the nondominant hemisphere. PMID: 19846345 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2921123 Sun, 18 Oct 2009 23:00:00 +0100 2921123 http://www.medworm.com/index.php?rid=2908946&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19837004%26dopt%3DAbstract Authors: Leunen D, Caroff X, Chmura S, Fohlen M, Delalande O, Jambaqué I Using an adaptation of Grober and Buschke's procedure, we assessed verbal and visuospatial learning abilities in 16 children after left or right anteromesial temporal resection and 16 healthy controls to evaluate material-specific memory deficits. All children had relatively well-preserved verbal and spatial learning capacities after unilateral temporal resection. Children who had left temporal resection showed impaired verbal memory performance despite semantic control by cued recall. No memory deficits with visual material were detected in children who underwent right anteromesial temporal resection. Grober and Buschke's procedure appears relevant for the detection of verbal memory disorders in children wit... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2908946 Wed, 14 Oct 2009 23:00:00 +0100 2908946 http://www.medworm.com/index.php?rid=2908950&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19836309%26dopt%3DAbstract This study addresses the functional relationship between postoperative object naming and semantic and phonological speech processing in patients with epilepsy. Fifty-eight consecutive patients with temporal lobe epilepsy from our epilepsy surgery program (24 patients with left temporal lobe epilepsy, 34 patients with right temporal lobe epilepsy) were investigated using the Boston Naming Test and comprehensive semantic and phonological speech testing. Language dominance was evaluated in all patients with the preoperative intracarotid sodium amytal test. Naming decline was observed exclusively in patients with left temporal lobe epilepsy. Regression analysis with semantic processing and phonological input/output processing as independent variables, and naming change in the Boston Naming Tes... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2908950 Tue, 13 Oct 2009 23:00:00 +0100 2908950 http://www.medworm.com/index.php?rid=2908949&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19836310%26dopt%3DAbstract Authors: Picard F, Craig AD The anatomical correlate of epileptic seizures with ecstatic auras has not been established. We document precise descriptions of the ecstatic seizures experienced by five patients, all of whom reported intense feelings of well-being and a heightened self-awareness. We propose here that the descriptions by these patients, together with the neurophysiological and neuroradiological evidence, support a theoretical framework for understanding ecstatic states based on hyperactivation of the anterior insula, rather than the temporal lobe. Epileptologists who have access to patients who experience episodic feelings of ecstasy and heightened self-awareness have an opportunity to provide insights that might help clarify the neural basis of consciousness. PMID: 198... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2908949 Tue, 13 Oct 2009 23:00:00 +0100 2908949 http://www.medworm.com/index.php?rid=2908948&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19836311%26dopt%3DAbstract Authors: Arida RM, Scorza FA, Terra VC, Scorza CA, de Almeida AC, Cavalheiro EA Stress has been considered the most frequently self-reported precipitant of seizures in people with epilepsy. The literature documents that physical stress, that is, physical exercise, can have beneficial effects in people with epilepsy. In view of evidence indicating that sensitivity to stress is reduced after a physical exercise program, physical activity could be a potential candidate for stress reduction in people with epilepsy. This review considers how physical exercise could contribute to reduce seizure susceptibility and, hence, seizure frequency. Possible mechanisms by which exercise can be beneficial for people with epilepsy are highlighted. Hypothalamic-pituitary-adrenal axis adaptation, neurotra... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2908948 Tue, 13 Oct 2009 23:00:00 +0100 2908948 http://www.medworm.com/index.php?rid=2908947&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19836312%26dopt%3DAbstract Authors: González-Trujano ME, López-Meraz L, Reyes-Ramírez A, Aguillón M, Martínez A Annonas are consumed as fresh fruits, but, because of their effects on the central nervous system, are also used in folk medicine. The effect on rat amygdala kindling of repeated administration of Annona diversifolia hexane (100mg/kg IP or PO) and ethanol (100mg/kg, PO) leaf extracts and palmitone (10mg/kg, IP) was determined. Electrographic and/or behavioral changes were monitored during kindling-induced seizures 60minutes after treatments. Antiepileptic efficacy was evaluated with respect to afterdischarge (AD) duration, spike frequency, and/or behavioral seizure activity. Oral administration of both extracts significantly decreased spike frequency, whereas intraperitoneally ... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2908947 Tue, 13 Oct 2009 23:00:00 +0100 2908947 http://www.medworm.com/index.php?rid=2903084&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19833560%26dopt%3DAbstract Authors: Besocke AG, Rojas JI, Valiensi SM, Cristiano E, Garcia MD The statistical concept of accuracy has never been applied to verify the history data collected on seizure disorders by open format interview. We compared patients'/witnesses' descriptions of epileptic seizures with videotaped seizure characteristics and analyzed the accuracy (ACC), sensitivity (SN), specificity (SP), false-positive rate (FPR), and false-negative rate (FNR) of various components of the semiology in patients with partial epilepsy. Language disturbances, complex automatisms, and autonomic signs have high ACC and intermediate FNRs. This means that these manifestations are most obvious to the witness/patient and, therefore, are memorized easily. Dystonic posturing and upper limb automatisms have the highest... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2903084 Mon, 12 Oct 2009 23:00:00 +0100 2903084 http://www.medworm.com/index.php?rid=2891708&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19818692%26dopt%3DAbstract Authors: Bakvis P, Spinhoven P, Roelofs K Previous studies have provided evidence for a vigilant attentional bias toward threat stimuli and increased basal diurnal cortisol levels in patients with psychogenic nonepileptic seizures (PNES). Because cortisol levels may be predictive of threat vigilance, we reanalyzed previous data on threat vigilance in 19 unmedicated patients with PNES and found a positive correlation between baseline cortisol levels and attentional bias scores for threat stimuli (r=0.49, P=0.035). There was no such relationship in healthy matched controls (n=20) or in patients with epileptic seizures (n=17). These findings provide the first evidence linking an endocrine stress marker to increased threat sensitivity in PNES and support new integrated psychoneurobiologica... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2891708 Tue, 06 Oct 2009 23:00:00 +0100 2891708 http://www.medworm.com/index.php?rid=2891707&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19818693%26dopt%3DAbstract In this study we used magnetoencephalography (MEG) to analyze memory profiles in patients with left hippocampal sclerosis (HS). Biomagnetic brain activity related to successful memory was compared in nine patients with left HS and nine age-matched controls. Patients manifested a higher number of activity sources over the right inferior parietal lobe in the late portion of the time window, and higher activity in the right than in the left MTL between 400 and 800ms. This was reinforced by a -0.46 MTL laterality index, which indicates right MTL dominance. Controls showed a higher number of dipoles in the left anterior ventral prefrontal region, between 400 and 600ms, and in the left MTL across the whole time window. Three patients who underwent a left temporal lobectomy, were seizure free, an... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2891707 Tue, 06 Oct 2009 23:00:00 +0100 2891707 http://www.medworm.com/index.php?rid=2880336&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19815465%26dopt%3DAbstract This study investigated the visual defects associated with the antiepileptic drug vigabatrin (VGB). Two hundred four people with epilepsy were grouped on the basis of antiepileptic drug therapy (current, previous, or no exposure to VGB). Groups were matched with respect to age, gender, and seizure frequency. All patients underwent objective assessment of electrophysiological function (wide-field multifocal electroretinography) and conventional visual field testing (static perimetry). Bilateral visual field constriction was observed in 59% of patients currently taking VGB, 43% of patients who previously took VGB, and 24% of patients with no exposure to VGB. Assessment of retinal function revealed abnormal responses in 48% of current VGB users and 22% of prior VGB users, but in none of the p... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2880336 Mon, 05 Oct 2009 23:00:00 +0100 2880336 http://www.medworm.com/index.php?rid=2866956&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19800851%26dopt%3DAbstract Authors: Aydemir N, Trung DV, Snape D, Baker GA, Jacoby A, We investigated issues related to treatment, impact of epilepsy, attitudes toward epilepsy, and disclosure in Vietnam through in-depth interviews with people with epilepsy (PWE) and their family members. We found that although participants prefer Western to traditional treatment, they experience problems in accessing different kinds of antiepileptic drugs and higher-level treatment facilities and with respect to treatment expenses. The impact of epilepsy can be observed in a wide range of daily living activities which include working, education, marriage, and family formation. Although both families and society at large do not hold negative attitudes toward epilepsy, most PWE reported a sense of burden to others. Both PWE and ... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2866956 Wed, 30 Sep 2009 23:00:00 +0100 2866956 http://www.medworm.com/index.php?rid=2857677&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19796993%26dopt%3DAbstract Authors: Barr WB, Bender HA, Morrison C, Cruz-Laureano D, Vazquez B, Kuzniecky R The Neuropsychological Screening Battery for Hispanics (NeSBHIS) was developed to address the growing need for linguistically appropriate Spanish-language assessment measures. Despite the potential benefits to clinical practice, no prior study has assessed its diagnostic validity in populations with epilepsy. One hundred and fifteen patients with confirmed epilepsy were evaluated via the NeSBHIS; these data were standardized according to age- and education-based norms. Performance decrements were observed in more than 40% of participants on measures of processing speed and naming. Deficits in verbal and visual recall were also exhibited by 29 and 26% of the sample, respectively. No significant differences ... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2857677 Mon, 28 Sep 2009 23:00:00 +0100 2857677 http://www.medworm.com/index.php?rid=2857679&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19793682%26dopt%3DAbstract We describe a 39-year-old patient with uncontrolled partial epilepsy who developed postictal periods of hypersexual aggression toward his wife after nocturnal convulsions. Following these seizures, he would have forced intercourse with his wife, followed by tremendous guilt and remorse when informed of his actions in the morning. Nocturnal convulsions and postictal hypersexuality resolved with a combination of lamotrigine and levetiracetam, more sleep, and stress management. The temporal features of the hypersexual behavior with respect to convulsions and the resolution of the behavior with seizure control support that aggressive hypersexuality can occur as a transient postictal behavioral change. The more intense nature of his symptoms compared with previously reported cases may reflect t... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2857679 Sun, 27 Sep 2009 23:00:00 +0100 2857679 http://www.medworm.com/index.php?rid=2857678&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19793683%26dopt%3DAbstract Authors: Sillanpää M, Schmidt D We determined if time to first remission predicts long-term antiepileptic drug response. We assessed time to first 1-year remission (1YR) as a determinant of entering future terminal 5-year remission (5YTR) in a population-based cohort of 144 children prospectively followed-up since their first unprovoked seizure before the age of 16years up to the mean age of 48years. The proportion of patients entering 5YTR was highly dependent on the length of time to first 1YR after starting adequate treatment. For 144 patients, the overall 5YTR rate decreased from 32% for those in remission at year 1 to 24% at year 2, to 5% after 3 and 4years, to 2% after 5years or longer. Patients who entered 1YR within the first 5years of treatment had an 11-fold better ... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2857678 Sun, 27 Sep 2009 23:00:00 +0100 2857678 http://www.medworm.com/index.php?rid=2852348&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19786368%26dopt%3DAbstract Authors: Ito M, Adachi N, Okazaki M, Kato M, Onuma T We investigated the relationship between dissociation and psychogenic nonepileptic seizures (PNES) and evaluated the clinical utility of the Dissociative Experience Scale (DES) in patients with epilepsy. The DES was administered to 30 patients with epilepsy and PNES, 50 patients with epilepsy and no PNES, and 85 nonclinical individuals. Patients with epilepsy and PNES scored significantly higher on the DES (29.3) than patients with epilepsy without PNES (13.5) and nonclinical individuals (11.1). High DES scores (>30) were more frequently observed in patients with epilepsy and PNES (53%) than in patients with epilepsy without PNES (12%) and nonclinical individuals (6%). DES score did not differ significantly with respect to epileps... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2852348 Fri, 25 Sep 2009 23:00:00 +0100 2852348 http://www.medworm.com/index.php?rid=2852347&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19786369%26dopt%3DAbstract Authors: Pavlova MK, Shea SA, Scheer FA, Bromfield EB Epileptiform abnormalities often occur at specific times of day or night, possibly attributable to state of consciousness (sleep vs. wake) and/or influences from the endogenous circadian pacemaker. In this pilot study we tested for the existence of circadian variation of interictal epileptiform discharges (IEDs), independent of changes in state, environment, or behavior. Five patients with generalized epilepsy underwent a protocol whereby their sleep/wake schedule was evenly distributed across the circadian cycle while undergoing full-montage electroencephalography and hourly plasma melatonin measurements. Light was <8 lux to prevent circadian entrainment. All patients completed the protocol, testifying to its feasibility. All pa... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2852347 Fri, 25 Sep 2009 23:00:00 +0100 2852347 http://www.medworm.com/index.php?rid=2843233&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19783217%26dopt%3DAbstract Authors: Mittan RJ Psychosocial problems are a major unmet treatment need in epilepsy. The purpose of this review was to describe published psychosocial treatment interventions in the English medical literature. Seventeen outcome studies for 15 treatments were found. Survival past proof of concept was a problem, with only four programs making it into current use. With important exceptions, treatments met with limited success. Several were successful with medical education, improving quality of life, social adjustment, and adjustment to seizures. A psychological intervention for seizure control for patients with refractory epilepsy was outstanding. Research problems included few control groups, a dependence on paper-and-pencil measures, limited variables, and only one study with serum d... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2843233 Thu, 24 Sep 2009 23:00:00 +0100 2843233 http://www.medworm.com/index.php?rid=2843232&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19783218%26dopt%3DAbstract Authors: Osorio I, Frei MG Substantive advances in clinical epileptology may be realized through the judicious use of real-time automated seizure detection, quantification, warning, and delivery of therapy in subjects with pharmacoresistant seizures. Materialization of these objectives is likely to elevate epileptology to the level of a mature clinical science. PMID: 19783218 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2843232 Thu, 24 Sep 2009 23:00:00 +0100 2843232 http://www.medworm.com/index.php?rid=2843231&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19783219%26dopt%3DAbstract Authors: Wu T, Chen CC, Chen TC, Tseng YF, Chiang CB, Hung CC, Liou HH The aim of this prospective, multicenter, open-label study was to investigate the efficacy of levetiracetam (LEV) and determine its effects on cognitive and neuropsychological function. Sixty-nine patients were evaluated for effects of LEV on seizure control, cognitive (Mini-Mental State Examination [MMSE]) and neuropsychological (Symptom Checklist-90 Revised [SCL-90-R]) functions, and quality of life (Quality of Life in Epilepsy-10 [QOLIE-10]) assessments at 3 and 12months of follow-up. Thirty-nine percent of patients achieved seizure freedom, and 68% had a 50% seizure frequency reduction after 1year of LEV (1235.5+/-392.7mg/day). There were also significant improvements in mean MMSE score and in the recall and lan... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2843231 Thu, 24 Sep 2009 23:00:00 +0100 2843231 http://www.medworm.com/index.php?rid=2843230&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19783220%26dopt%3DAbstract We examined employment outcome and its determinants in 172 south Indian patients who had undergone anterior temporal lobectomy (ATL) for medically refractory epilepsy. Despite seizure-free outcome in the majority, a significant change in post-ATL employment status occurred only in those involved in skilled jobs. Although factors such as younger age at surgery, shorter duration of epilepsy, longer post-ATL follow-up duration, and lower income were associated with favorable employment outcome in univariate analysis, only shorter duration of epilepsy was independently predictive in the multivariate model. A majority of homemakers appreciated marked improvement in their own day-to-day activities. Our patients did not express their desire to work as a principal aim of epilepsy surgery. To enhan... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2843230 Thu, 24 Sep 2009 23:00:00 +0100 2843230 http://www.medworm.com/index.php?rid=2843234&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19782646%26dopt%3DAbstract Authors: Osborne DM, Frye CA Sex steroids can influence seizures. Estrogen (E(2)), progesterone (P(4)), and its metabolite, 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP), in particular, have received much attention for exerting these effects. Typically, it is thought that E(2) precipitates seizures, and progestogens, such as P(4) and 3alpha,5alpha-THP, attenuate seizures. However, E(2) may also have antiseizure effects, perhaps in part through its enhancement of the formation of 3alpha,5alpha-THP, which has GABA(A)/benzodiazepine receptor agonist-like actions. To test this hypothesis, male and female, castrated or ovariectomized, wild-type and 5alpha-reductase knockout mice were implanted with Silastic capsules of E(2) or vehicle and then administered pentylenetetrazol (85mg/kg, ... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2843234 Wed, 23 Sep 2009 23:00:00 +0100 2843234 http://www.medworm.com/index.php?rid=2843237&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19782004%26dopt%3DAbstract Authors: Selmer KK, Lund C, Brandal K, Undlien DE, Brodtkorb E Mutations in the SCN1A gene have been identified in a variety of epilepsy phenotypes, from severe encephalopathies such as Dravet syndrome to milder familial forms such as generalized epilepsy with febrile seizures plus. In a previous study, an SCN1A mutation was also identified in a patient with Lennox-Gastaut syndrome (LGS), and the aim of our study was to investigate the importance of mutations in the SCN1A gene in Norwegian patients with clinical features of LGS. We screened 22 adult patients for SCN1A mutations by direct sequencing of DNA and for micro-rearrangements with multiplex ligation-dependent probe amplification. In one patient a mutation was found, which demonstrates a clinical overlap between LGS and Dravet s... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2843237 Tue, 22 Sep 2009 23:00:00 +0100 2843237 http://www.medworm.com/index.php?rid=2843236&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19782005%26dopt%3DAbstract Authors: Smith G, Ferguson PL, Saunders LL, Wagner JL, Wannamaker BB, Selassie AW Living Well with Epilepsy II called for further attention to stigma and its impact on people with epilepsy. In response, the South Carolina Health Outcomes Project on Epilepsy (SC HOPE) is examining the relationship between socioeconomic status, epilepsy severity, health care utilization, and quality of life in persons diagnosed with epilepsy. The current analysis quantifies perceived stigma reported by adults with epilepsy in relation to demographic, seizure-related, health, and psychosocial factors. It was found that reported levels of stigma were associated with interactions of seizure worry and employment status, self-efficacy and social support, and quality care and age at seizure onset. This informa... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2843236 Tue, 22 Sep 2009 23:00:00 +0100 2843236 http://www.medworm.com/index.php?rid=2843235&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19782006%26dopt%3DAbstract Authors: Jaseja H Electroencephalography is an important, noninvasive, and useful technique for identifying an epileptogenic region. Electroencephalogram (EEG)-identified interictal epileptiform discharges (IEDs) have been found to correlate well with local metabolic changes in the brain as studied by neuroradiological examinations. In-depth studies on IEDs have revealed not only their multidimensional influence on neural functioning, but also a potential damaging effect on neurons signifying their nonbenign nature. Yet, the issue of treatment of the EEG has remained a topic of intense debate. In this brief article an attempt is made to justify the significance of treatment of the EEG and its impact on the overall prognostic outcome and quality of life of patients with abnormal EEGs. ... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2843235 Tue, 22 Sep 2009 23:00:00 +0100 2843235 http://www.medworm.com/index.php?rid=2832938&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19775939%26dopt%3DAbstract This study was designed (1) to compare the prevalence of emergency department (ED) presentations in Western Zone Sydney South West Area Health Service (WZS) between 1998-2002 and 2003-2007 for epilepsy (including status epilepticus (SE) and convulsions), hospital admission rates, and proportion of first seizure presentations; and (2) to compare these data with those for New South Wales (NSW) and Australia-wide figures. Using health department data sets, we found 19,834 presentations to WZS EDs between 1998 and 2007 (24.85/10,000 population/year). When the periods 2003-2007 and 1998-2002 in WZS are compared, ED presentations fell by 3% (P=0.03) and hospital admissions fell by 6% (P=0.001). The prevalence of ED presentations for seizures in NSW did not change (P=0.92), but hospital admission... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2832938 Sun, 20 Sep 2009 23:00:00 +0100 2832938 http://www.medworm.com/index.php?rid=2820698&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19767242%26dopt%3DAbstract We report our 6months of experience with adjunctive lacosamide in 25 patients with pharmacoresistant focal epilepsy. Baseline characteristics of our patients were similar to those of the populations in the three clinical trials that evaluated lacosamide for refractory focal epilepsy. One patient experienced sustained seizure freedom for 5months; two more patients had nonsustained periods of seizure freedom of 1 and 4months. A total of eight patients (32%) reported a greater than 50% reduction in seizure frequency. Thirteen patients (52%) reported side effects during the titration, mostly dizziness, fatigue, nausea, and gait instability. In five patients (20%), these disappeared during the maintenance phase and/or with dose reduction. Two patients lost more than 10% of their body weight. Ot... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2820698 Thu, 17 Sep 2009 23:00:00 +0100 2820698 http://www.medworm.com/index.php?rid=2820697&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19767243%26dopt%3DAbstract Authors: Vendrame M, Alexopoulos AV, Boyer K, Gregas M, Haut J, Lineweaver T, Wyllie E, Loddenkemper T We assessed the impact of age at onset of epilepsy and duration and frequency of seizures on cognitive development in children less than 3years old. Retrospective analysis was conducted on clinical data and neuropsychological testing of 33 infants with epilepsy. Developmental quotients were calculated and were correlated with age at epilepsy onset, duration of epilepsy, seizure frequency, brain pathology, and types of seizures (with/without spasms) as potential predictors. Infants with longer duration and earlier onset of epilepsy performed worse on developmental neuropsychological testing. Regression analyses showed that age at epilepsy onset and percentage of life with epilepsy were... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2820697 Thu, 17 Sep 2009 23:00:00 +0100 2820697 http://www.medworm.com/index.php?rid=2820696&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19767244%26dopt%3DAbstract CONCLUSIONS: VNS is a safe and effective treatment option for medically refractory epilepsy in patients with tuberous sclerosis complex. Nine of 11 patients (82%) experienced at least a 67% reduction in seizure burden. Lack of response to vagus nerve stimulation does not preclude subsequent improvement in seizure burden with intracranial epilepsy surgery. PMID: 19767244 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2820696 Thu, 17 Sep 2009 23:00:00 +0100 2820696 http://www.medworm.com/index.php?rid=2820701&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19766539%26dopt%3DAbstract We examined if cortical kindling could induce changes in excitatory and inhibitory receptor subunit mRNA in the amygdala/piriform regions and if such changes are associated with behavioral deficits. After cortical kindling, amygdala/piriform regions were dissected to analyze mRNA levels of NMDA, AMPA, and GABA receptor subunits using reverse transcription polymerase chain reaction, or rats were subjected to a series of behavioral tests. Kindled rats had significantly greater amounts of GluR1 and GluR2 AMPA receptor mRNA, and alpha1 and alpha2 GABA receptor subunit mRNA, compared with sham controls, which was associated with greater anxiety-like behaviors in the elevated plus maze and reduced freezing behaviors in the fear conditioning task. In summary, cortical kindling produces dynamic re... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2820701 Wed, 16 Sep 2009 23:00:00 +0100 2820701 http://www.medworm.com/index.php?rid=2820700&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19766540%26dopt%3DAbstract Authors: Anderson GD, Temkin NR, Dikmen SS, Diaz-Arrastia R, Machamer JE, Farhrenbruch C, Miller JW, Sadrzadeh SM The relationship of genetic predisposition to reduced iron capacity and apolipoprotein E (APOE) to posttraumatic seizures (PTSs) and neuropsychological outcomes was investigated in patients with traumatic brain injuries from a prior valproate clinical study. Haptoglobin concentration/phenotype and APOE genotype were determined in 25 patients with PTSs and 26 control (no PTSs) subjects approximately 10years after traumatic brain injury. Haptoglobin phenotype was also determined in previously collected frozen samples for 25 additional patients with PTSs and 32 no-PTS subjects. There was no relationship between haptoglobin phenotype or APOE genotype and occurrence of PTSs. APO... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2820700 Wed, 16 Sep 2009 23:00:00 +0100 2820700 http://www.medworm.com/index.php?rid=2820699&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19766541%26dopt%3DAbstract Authors: Schreibman Cohen A, Daley M, Siddarth P, Levitt J, Loesch IK, Altshuler L, Ly R, Shields WD, Gurbani S, Caplan R Abnormal amygdala volumes in pediatric mood-anxiety disorders and attention deficit hyperactivity disorder (ADHD), as well as high rates of these diagnoses in childhood absence epilepsy (CAE), prompted this study of amygdala volume in CAE. Twenty-six children with CAE and 23 normal children, aged 6.6-15.8years, underwent MRI at 1.5T. The tissue imaged with MRI was segmented, and amygdala volumes were obtained by manual tracings. There were no significant amygdala volume differences between the CAE and normal groups. Within the CAE group, however, the children with ADHD had significantly smaller amygdala volumes than the subjects with CAE with no psychopathology and ... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2820699 Wed, 16 Sep 2009 23:00:00 +0100 2820699 http://www.medworm.com/index.php?rid=2820702&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19766060%26dopt%3DAbstract Authors: Cysneiros RM, Arida RM, Terra VC, Sonoda EY, Cavalheiro EA, Scorza FA PMID: 19766060 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2820702 Tue, 15 Sep 2009 23:00:00 +0100 2820702 http://www.medworm.com/index.php?rid=2812741&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19762284%26dopt%3DAbstract Authors: Osorio I, Chang FC, Gopalsami N Automated seizure blockage is a top priority in epileptology. Lowering nervous tissue temperature below a certain level suppresses abnormal neuronal activity, an approach with certain advantages over electrical stimulation, the preferred investigational therapy for pharmacoresistant seizures. A computer model was developed to identify an efficient probe design and parameters that would allow cooling of brain tissue by no less than 21 degrees C in 30s, maximum. The Pennes equation and the computer code ABAQUS were used to investigate the spatiotemporal behavior of heat diffusivity in brain tissue. Arrays of distributed probes deliver sufficient thermal energy to decrease, inhomogeneously, brain tissue temperature from 37 to 20 degrees C in 30s an... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2812741 Mon, 14 Sep 2009 23:00:00 +0100 2812741 http://www.medworm.com/index.php?rid=2812740&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19762285%26dopt%3DAbstract Authors: Burket JA, Mastropaolo J, Rosse RB, Deutsch SI The inbred Balb/c mouse strain was more sensitive than the outbred NIH Swiss mouse to flurazepam's ability to antagonize electrically precipitated seizures. In prior work, a reduction in flurazepam's antiseizure efficacy was not observed 24h after forcing Balb/c mice to swim for up to 10min in ambient temperature water. Thus, we wondered if a stress-induced reduction would be observed after forcing mice to swim for up to 10min in cold (6 degrees C) water, a more severe stress. The current data show that 24h after exposure to this stress, the ability of flurazepam to raise the threshold voltage for the elicitation of tonic hindlimb extension in the Balb/c mouse strain was reduced. The genetically inbred Balb/c mouse strain is emerg... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=2812740 Mon, 14 Sep 2009 23:00:00 +0100 2812740