MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Epilepsy and Behaviour' source. Wed, 08 Feb 2012 20:43:06 +0100 http://www.medworm.com/index.php?rid=5607556&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22236571%26dopt%3DAbstract Authors: Direk N, Kulaksizoglu IB, Alpay K, Gurses C Abstract Identifying psychiatric disorders rather than psychiatric symptoms might help to distinguish patients with psychogenic nonepileptic seizures (PNES) from those with epileptic seizures (ES). Patients with PNES (n=35), patients with ES (n=35), and healthy controls (n=37) were compared with respect to the prevalence of psychiatric disorders in this study. We tested the predictive power of having axis I psychiatric disorders, as well as personality disorders, in distinguishing ES from PNES. There was no significant difference between the patient groups in the prevalence of axis I psychiatric disorders. Personality disorders were more prevalent in the PNES group than in the ES group (P<0.05). Having a personality disorder w... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5607556 Tue, 10 Jan 2012 05:00:00 +0100 5607556 http://www.medworm.com/index.php?rid=5607555&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22236572%26dopt%3DAbstract Authors: Ali F, Rickards H, Cavanna AE Abstract A wide range of controversial definitions and dynamic components surround the multi-dimensional concept of consciousness, with important reflections on the phenomenological description of ictal states relevant to epileptic seizures. The inadequacies of terminology, the insufficient emphasis on the subjective nature of consciousness, as well as the intrinsic limitations of the simple versus complex dichotomy for partial seizures, are to be considered in view of a modern definition of consciousness. In this paper, we review the difficulties encountered by clinicians in assessing the ictal conscious state in patients with epilepsy, and illustrate how a more sophisticated bi-dimensional model of consciousness can prove a valuable conceptu... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5607555 Mon, 09 Jan 2012 05:00:00 +0100 5607555 http://www.medworm.com/index.php?rid=5607554&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22236573%26dopt%3DAbstract Authors: Korchounov A, Tabatadze T, Spivak D, Rössy W Abstract Epilepsy-related employment prevalence and retirement incidence were investigated in the German working population from 1994 to 2009. The overall mean prevalence of employment of people with epilepsy was 5.1±0.2 per 1000 workers. The employment rate among people with epilepsy increased from 63.5% in 1994 to 65.9% in 2000 (0.4% annually) and then more steeply from 66.8% in 2001 to 76.9% in 2009 (1.4% annually). A prominent increase in rate of employment of people with epilepsy since 2001 was temporarily associated with approval of leviteracetam in 2000 (P<0.001, OR=8.3, CI=6.45-10.12). The overall mean employment rate of people with epilepsy was lower than that of the general population (68.5% vs 90.1%, P<0.001).... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5607554 Mon, 09 Jan 2012 05:00:00 +0100 5607554 http://www.medworm.com/index.php?rid=5607560&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22227592%26dopt%3DAbstract Authors: Friedman DE, Chiang S, Tobias RS Abstract Seizure-related head injuries (SRHIs) are among the most commonly encountered injuries in people with epilepsy (PWE). Whether head injury has an effect on preexisting epilepsy is not known. The purpose of this study was to systematically assess for any possible effects of SRHIs on seizure frequency and seizure semiology over a 2-year period. We identified 204 patients who have been followed at the Baylor Comprehensive Epilepsy Center from 2008 to 2010. SRHI occurred in 18.1% of the cohort. Most injuries (91%) were classified as mild. Though seizure frequency varied following head injury, overall seizure frequency was not significantly impacted by presence or absence of SRHI over the 2-year study period. Changes in seizure semiology... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5607560 Fri, 06 Jan 2012 05:00:00 +0100 5607560 http://www.medworm.com/index.php?rid=5607559&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22227593%26dopt%3DAbstract CONCLUSION: Limitations, that is, heterogeneity among studies, examining the English literature from 1994 to 2010, must be considered. Yet, this is the first evidence-based review to synopsize the current PWE and driving literature and to provide recommendation(s) to clinicians and policy makers. Class I studies, matched for age and gender, yielding Level A recommendations are urgently needed to define the risks, benefits, and causal factors underlying driving performance issues in PWE. PMID: 22227593 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5607559 Fri, 06 Jan 2012 05:00:00 +0100 5607559 http://www.medworm.com/index.php?rid=5607558&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22227594%26dopt%3DAbstract We examined CP and its relationship to general intellectual ability and seizure focus in 90 patients with pediatric epilepsy. CP was significantly lower than general ability (GA) in the overall sample. In particular, it was more deficient than GA in patients with right- than left-lateralized epilepsy onset, and in patients with frontal- than temporal-onset epilepsy. The discrepancy between CP and GA varied with participants' overall intelligence, being more pronounced (i.e., GA-CP difference larger) in individuals of lower overall ability. Deficits in CP are a defining characteristic of pediatric epilepsy and serve as an important marker of neurocognitive status, especially when seizures originate from a primary epileptogenic focus within the right hemisphere or the frontal lobe. PMID:... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5607558 Fri, 06 Jan 2012 05:00:00 +0100 5607558 http://www.medworm.com/index.php?rid=5607557&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22227595%26dopt%3DAbstract Authors: Lima RC, Silva MC, Aguiar CC, Chaves EM, Dias KC, Macêdo DS, de Sousa FC, Carvalho KD, Ramos MV, Vasconcelos SM Abstract Calotropis procera (Ait.) R.Br. is a laticiferous plant belonging to the Apocynaceae family. C. procera latex proteins were evaluated with respect to anticonvulsant and sedative activity in mouse models of pentylenetetrazol (PTZ)-, pilocarpine-, and strychnine-induced convulsions or turning behavior and pentobarbital-induced sleep. In the strychnine- and pilocarpine-induced seizure models, C. procera latex proteins caused no significant alterations in latencies to convulsions and death, as compared with controls. In the PTZ-induced seizure model, administration of C. procera latex proteins in high doses (50 or 100mg/kg) and diazepam caused significant i... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5607557 Fri, 06 Jan 2012 05:00:00 +0100 5607557 http://www.medworm.com/index.php?rid=5607562&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22227033%26dopt%3DAbstract Authors: Sirven JI PMID: 22227033 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5607562 Thu, 05 Jan 2012 05:00:00 +0100 5607562 http://www.medworm.com/index.php?rid=5607561&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22227034%26dopt%3DAbstract We describe a 19-year-old man known to have epileptic seizures, in which both magnetoencephalography (MEG)-unique and EEG/MEG spikes were seen. Both types of spikes originated from the same source, but the EEG/MEG spikes were of significantly higher magnitude than the MEG-unique spikes. Therefore, some epileptic seizures, even though generated identically to the MEG-positive seizures, could be EEG-negative because of their smaller magnitude. PMID: 22227034 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5607561 Thu, 05 Jan 2012 05:00:00 +0100 5607561 http://www.medworm.com/index.php?rid=5607563&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22225923%26dopt%3DAbstract Authors: Battaglia D, Chieffo D, Tamburrini G, Lettori D, Losito E, Leo G, Ranalli D, Giansanti C, Antichi E, Caldarelli M, Di Rocco C, Guzzetta F Abstract The aim of this study was to provide information on the neuropsychological evolution of children with symptomatic epilepsy who have undergone surgical resection of posterior (occipitoparietal) lesions. Twelve children with epilepsy with parietal and/or occipital lesions were enrolled in the study and followed after surgical resection: full clinical and epileptic examinations were performed before and after surgery, as was a neuropsychological study of both general and specific cognitive abilities. Epilepsy evolution was generally good (Engel classification IA in nine cases) with persistent selective neurological impairments (eye... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5607563 Wed, 04 Jan 2012 05:00:00 +0100 5607563 http://www.medworm.com/index.php?rid=5570062&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22209327%26dopt%3DAbstract Authors: Butler T, Weisholtz D, Isenberg N, Harding E, Epstein J, Stern E, Silbersweig D Abstract Psychosis is a devastating, prevalent condition considered to involve dysfunction of frontal and medial temporal limbic brain regions as key nodes in distributed brain networks involved in emotional regulation. The psychoses of epilepsy represent an important, though understudied, model relevant to understanding the pathophysiology of psychosis in general. In this review, we (1) discuss the classification of epilepsy-related psychoses and relevant neuroimaging and other studies; (2) review structural and functional neuroimaging studies of schizophrenia focusing on evidence of frontal-limbic dysfunction; (3) report our laboratory's PET, fMRI, and electrophysiological findings; (4) descr... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5570062 Wed, 28 Dec 2011 05:00:00 +0100 5570062 http://www.medworm.com/index.php?rid=5553697&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22206825%26dopt%3DAbstract Authors: Gorham R, Persinger MA Abstract To pursue Richard Roberts' epileptic spectrum disorder (ESD) and the emergence of complex partial epilepsy-like experiences, items and total scores for the ESD Inventory were examined for 185 patients who had sustained mechanical impacts (and were diagnosed with or without neuropsychological impairment) and a reference group (n=68) of university students. Results from neuropsychological, personality, neurological screening, and interview data supported the role of temporal lobe origins for these experiences. The incidences of these experiences were sufficient to adversely affect adaptation and to produce psychiatric profiles. Although only 70% of the patients who were impaired versus not impaired could be differentiated by items from the ESD... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5553697 Tue, 27 Dec 2011 05:00:00 +0100 5553697 http://www.medworm.com/index.php?rid=5553698&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22200495%26dopt%3DAbstract We describe two patients with no previous history of seizures or evidence of intracerebral lesions who, during detoxification for benzodiazepine abuse, developed repetitive focal nonconvulsive seizures instead of generalized seizures, even with appropriate doses of preventive AED therapy. There are no previous reported cases of focal nonconvulsive seizures occurring during this procedure or, more generally, during abrupt BDZ discontinuation. The cases we describe suggest that during detoxification for BDZ abuse, not only generalized, but also focal nonconvulsive seizures may occur. In this context, the focal seizures probably result from a diffuse decrease in the seizure threshold (caused by a generalized excitatory rebound), which may trigger focal seizures arising from cortical regions w... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5553698 Sat, 24 Dec 2011 05:00:00 +0100 5553698 http://www.medworm.com/index.php?rid=5553701&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22197717%26dopt%3DAbstract Authors: Mendonça PR, Amorim HA, Scorza CA, Arida RM, Cavalheiro EA, Scorza FA PMID: 22197717 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5553701 Fri, 23 Dec 2011 05:00:00 +0100 5553701 http://www.medworm.com/index.php?rid=5553700&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22197718%26dopt%3DAbstract Authors: Schwan R, Hingray C, Laprevote V, Vignal JP, Maillard L PMID: 22197718 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5553700 Fri, 23 Dec 2011 05:00:00 +0100 5553700 http://www.medworm.com/index.php?rid=5553699&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22197719%26dopt%3DAbstract This study explores the language reorganization before and after surgery in a 55-year-old right-handed female patient presenting with left temporal refractory epilepsy. Two aspects of language were explored, phonological and semantic, by using neuropsychological assessments and fMRI protocols. To assess the possible reorganization of language, fMRI results for B.L. were compared with results obtained in a group of healthy control subjects (results not presented in detail). According to our results and compared with healthy subjects, B.L. shows reorganization of temporal regions only. The reorganization had various patterns according to the task. Before surgery, neuropsychological testing in B.L. revealed impairment in phonological abilities and fMRI suggested right temporal involvement (in... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5553699 Fri, 23 Dec 2011 05:00:00 +0100 5553699 http://www.medworm.com/index.php?rid=5553704&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22197123%26dopt%3DAbstract We describe a patient with gelastic seizures involving the left parietal lobe. Our patient, an 8-year-old girl, underwent interictal video/EEG monitoring and MRI. The seizures consisted of brief staring followed by smiling and laughing. Electroencephalography during the gelastic seizures showed rhythmic spikes and waves in the left parietal lobe. MRI revealed the characteristic features of focal cortical dysplasia. Our findings suggest that the left parietal lobe may actively participate in the particular epileptogenic network generating gelastic seizures. PMID: 22197123 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5553704 Thu, 22 Dec 2011 05:00:00 +0100 5553704 http://www.medworm.com/index.php?rid=5553703&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22197124%26dopt%3DAbstract Authors: Zangaladze A, Skidmore C Abstract Treatment of refractory idiopathic primary generalized epilepsy can be very challenging, with limited drug options, especially in young women of childbearing age. Here we describe the cases of two young women with refractory idiopathic primary generalized epilepsy refractory to multiple antiepileptic drugs in monotherapy or combination before achieving a long-term remission with adjunctive lacosamide (LCS) treatment. Larger, randomized prospective studies are necessary to establish the effectiveness of lacosamide in these patients. PMID: 22197124 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5553703 Thu, 22 Dec 2011 05:00:00 +0100 5553703 http://www.medworm.com/index.php?rid=5553702&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22197125%26dopt%3DAbstract Authors: Lancman G, Vazquez-Casals GA, Perrine K, Feoli E, Myers L Abstract In presurgical treatment planning for patients with epilepsy, neuropsychological testing assists in lateralization of the seizure focus. Previous research with English speakers has shown that patients with left hemisphere (LH) onsets versus right hemisphere (RH) onsets perform worse on naming and other verbal skills tests, but similar findings with Hispanic patients are limited. Thirty-nine Spanish-speaking patients were administered a comprehensive battery of neuropsychological tests in Spanish. LH-onset patients performed significantly worse than RH-onset patients on verbal comprehension (P=0.006), visual matching (P=0.047), the Ponton-Satz Boston Naming Test (P=0.001), and the dominant hand trial of the ... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5553702 Thu, 22 Dec 2011 05:00:00 +0100 5553702 http://www.medworm.com/index.php?rid=5541123&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22189155%26dopt%3DAbstract Authors: Brooks DR, Avetisyan R, Jarrett KM, Hanchate A, Shapiro GD, Pugh MJ, Berlowitz DR, Thurman D, Montouris G, Kazis LE Abstract We evaluated the validity of questions designed to identify lifetime and active epilepsy, medication use, and seizure occurrence on population-based surveys. Subjects were interviewed by telephone, and responses were compared with information in their medical records. Prevalence, sensitivity, specificity, and positive predictive value (PPV) were calculated. The prevalence of ever having been diagnosed with epilepsy was 3.1% by self-report and 2.7% by medical record review. Sensitivity was 84.2%, specificity was 99.2%, and PPV was 73.5% for self-reported lifetime epilepsy, and values were similar for active epilepsy. By comparison, sensitivity was hig... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5541123 Tue, 20 Dec 2011 05:00:00 +0100 5541123 http://www.medworm.com/index.php?rid=5519191&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22154515%26dopt%3DAbstract Authors: Crail-Meléndez D, Herrera-Melo A, Martínez-Juárez IE, Ramírez-Bermúdez J Abstract Depression has a high prevalence among patients with temporal lobe epilepsy (TLE). A pilot study was carried out to evaluate group cognitive-behavioral therapy (CBT) as a treatment for depression in patients with TLE. Twenty-three outpatients with TLE and major depressive disorder, according to DSM-IV criteria, were enrolled and divided into two groups to receive 16 weekly sessions of CBT. The primary outcome measures were depression severity (assessed with the Beck Depression Inventory) and quality of life (measured with the Quality of Life in Epilepsy-31). Sixteen patients (70%) completed at least 80% of the sessions. From week 8, CBT had a significant positive effect on severity of de... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5519191 Fri, 09 Dec 2011 05:00:00 +0100 5519191 http://www.medworm.com/index.php?rid=5482951&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22078509%26dopt%3DAbstract Authors: Osorio I PMID: 22078509 [PubMed - in process] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5482951 Thu, 01 Dec 2011 05:00:00 +0100 5482951 http://www.medworm.com/index.php?rid=5482950&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22078510%26dopt%3DAbstract This article is part of a Supplemental Special Issue entitled The Future of Automated Seizure Detection and Prediction. PMID: 22078510 [PubMed - in process] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5482950 Thu, 01 Dec 2011 05:00:00 +0100 5482950 http://www.medworm.com/index.php?rid=5482949&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22078511%26dopt%3DAbstract This article is part of a Supplemental Special Issue entitled The Future of Automated Seizure Detection and Prediction. PMID: 22078511 [PubMed - in process] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5482949 Thu, 01 Dec 2011 05:00:00 +0100 5482949 http://www.medworm.com/index.php?rid=5482948&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22078512%26dopt%3DAbstract This article is part of a Supplemental Special Issue entitled The Future of Automated Seizure Detection and Prediction. PMID: 22078512 [PubMed - in process] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5482948 Thu, 01 Dec 2011 05:00:00 +0100 5482948 http://www.medworm.com/index.php?rid=5482947&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22078513%26dopt%3DAbstract This article is part of a Supplemental Special Issue entitled The Future of Automated Seizure Detection and Prediction. PMID: 22078513 [PubMed - in process] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5482947 Thu, 01 Dec 2011 05:00:00 +0100 5482947 http://www.medworm.com/index.php?rid=5482946&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22078514%26dopt%3DAbstract This article is part of a Supplementary Special Issue entitled The Future of Automated Seizure Detection and Prediction. PMID: 22078514 [PubMed - in process] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5482946 Thu, 01 Dec 2011 05:00:00 +0100 5482946 http://www.medworm.com/index.php?rid=5482945&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22078515%26dopt%3DAbstract This article addresses the problem of real-time seizure detection from intracranial EEG (IEEG). One difficulty in creating an approach that can be used for many patients is the heterogeneity of seizure IEEG patterns across different patients and even within a patient. In addition, simultaneously maximizing sensitivity and minimizing latency and false detection rates has been challenging as these are competing objectives. Automated machine learning systems provide a mechanism for dealing with these hurdles. Here we present and evaluate an algorithm for real-time seizure onset detection from IEEG using a machine-learning approach that permits a patient-specific solution. We extract temporal and spectral features across all intracranial EEG channels. A pattern recognition component is trained... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5482945 Thu, 01 Dec 2011 05:00:00 +0100 5482945 http://www.medworm.com/index.php?rid=5482944&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22078516%26dopt%3DAbstract This article is part of a Supplemental Special Issue entitled The Future of Automated Seizure Detection and Prediction. PMID: 22078516 [PubMed - in process] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5482944 Thu, 01 Dec 2011 05:00:00 +0100 5482944 http://www.medworm.com/index.php?rid=5482943&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22078517%26dopt%3DAbstract This article addresses interpretation of clinical signs and symptoms in the context of the diagnostic predictive value of electroencephalographic, clinical, and electrographic definitions of seizures, and upcoming challenges of interpreting intracranial high-frequency electroencephalographic data. This article is part of a Supplemental Special Issue entitled The Future of Automated Seizure Detection and Prediction. PMID: 22078517 [PubMed - in process] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5482943 Thu, 01 Dec 2011 05:00:00 +0100 5482943 http://www.medworm.com/index.php?rid=5482942&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22078518%26dopt%3DAbstract This article is part of a Supplemental Special Issue entitled The Future of Automated Seizure Detection and Prediction. PMID: 22078518 [PubMed - in process] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5482942 Thu, 01 Dec 2011 05:00:00 +0100 5482942 http://www.medworm.com/index.php?rid=5482941&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22078519%26dopt%3DAbstract This article is part of a Supplemental Special Issue entitled The Future of Automated Seizure Detection and Prediction. PMID: 22078519 [PubMed - in process] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5482941 Thu, 01 Dec 2011 05:00:00 +0100 5482941 http://www.medworm.com/index.php?rid=5482940&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22078520%26dopt%3DAbstract This article is part of a Supplemental Special Issue entitled The Future of Automated Seizure Detection and Prediction. PMID: 22078520 [PubMed - in process] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5482940 Thu, 01 Dec 2011 05:00:00 +0100 5482940 http://www.medworm.com/index.php?rid=5482939&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22078521%26dopt%3DAbstract This study also suggests that currently available seizure detection software does not perform sufficiently in detection of nonconvulsive seizures in critically ill patients. This article is part of a Supplemental Special Issue entitled The Future of Automated Seizure Detection and Prediction. PMID: 22078521 [PubMed - in process] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5482939 Thu, 01 Dec 2011 05:00:00 +0100 5482939 http://www.medworm.com/index.php?rid=5482938&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22078522%26dopt%3DAbstract This article is part of a Supplemental Special Issue entitled The Future of Automated Seizure Detection and Prediction. PMID: 22078522 [PubMed - in process] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5482938 Thu, 01 Dec 2011 05:00:00 +0100 5482938 http://www.medworm.com/index.php?rid=5482937&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22078523%26dopt%3DAbstract This article is part of a Supplemental Special Issue entitled The Future of Automated Seizure Detection and Prediction. PMID: 22078523 [PubMed - in process] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5482937 Thu, 01 Dec 2011 05:00:00 +0100 5482937 http://www.medworm.com/index.php?rid=5482936&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22078524%26dopt%3DAbstract This article is part of a Supplemental Special Issue entitled The Future of Automated Seizure Detection and Prediction. PMID: 22078524 [PubMed - in process] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5482936 Thu, 01 Dec 2011 05:00:00 +0100 5482936 http://www.medworm.com/index.php?rid=5482935&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22078525%26dopt%3DAbstract This article is part of a Supplemental Special Issue entitled The Future of Automated Seizure Detection and Prediction. PMID: 22078525 [PubMed - in process] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5482935 Thu, 01 Dec 2011 05:00:00 +0100 5482935 http://www.medworm.com/index.php?rid=5482934&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22078526%26dopt%3DAbstract This article is part of a Supplemental Special Issue entitled The Future of Automated Seizure Detection and Prediction. PMID: 22078526 [PubMed - in process] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5482934 Thu, 01 Dec 2011 05:00:00 +0100 5482934 http://www.medworm.com/index.php?rid=5482933&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22142783%26dopt%3DAbstract Authors: Cusmai R, Moavero R, Bombardieri R, Vigevano F, Curatolo P Abstract In tuberous sclerosis complex, early seizure onset is associated with high risk of intractable epilepsy and cognitive/behavioral impairment. We retrospectively evaluated the long-term outcome of 44 infants presenting with seizures in the first 12months who received vigabatrin, and were followed up for at least 3.5years. At the final evaluation 55% of patients were still having seizures, 80% had intellectual disability, and 30% had autism. Sixty-five percent of children who had been treated earlier with vigabatrin after seizure onset achieved seizure freedom, compared with 24% of subjects who received vigabatrin treatment later (P<0.01). Intellectual disability was present in 61% of the children treated ... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5482933 Thu, 01 Dec 2011 05:00:00 +0100 5482933 http://www.medworm.com/index.php?rid=5482954&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22134096%26dopt%3DAbstract This study supports the notion that stigmatization associated with seizures continues to flourish, as 41% of "seizure" tweets were derogatory in nature. Although Twitter could be used to disseminate accurate information on seizures and epilepsy, this study suggests that it is currently propagating negative attitudes toward seizures with potential for fueling stigma. In recent years there have been significant advancements in technology offering many new methods of sharing information. Social networking sites allow real-time communication while providing the opportunity for exchange of information and opinions. Twitter, a website launched in 2006, allows users to communicate through "tweets" limited to 140 characters. Twitter's popularity has drastically increased since its inception, with ... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5482954 Tue, 29 Nov 2011 05:00:00 +0100 5482954 http://www.medworm.com/index.php?rid=5482953&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22134097%26dopt%3DAbstract Authors: Fitzsimons M, Normand C, Varley J, Delanty N Abstract Advances in medical science and technology, together with improved medical and nursing care, are continuously improving health outcomes in chronic illness, including epilepsy. The consequent increasing diagnostic and therapeutic complexity is placing a burgeoning strain on health care systems. In response, an international move to transform chronic disease management (CDM) aims to optimize the quality and safety of care while containing health care costs. CDM models recommend: integration of care across organizational boundaries that is supported with information and communication technology; patient self-management; and guideline implementation to promote standardized care. Evidence of the effectiveness of CDM models i... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5482953 Tue, 29 Nov 2011 05:00:00 +0100 5482953 http://www.medworm.com/index.php?rid=5482952&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22134098%26dopt%3DAbstract Authors: Baca CB, Vickrey BG, Vassar SD, Berg AT Abstract Health-related quality of life (HRQOL) is associated with seizure recency among adults with epilepsy. In a prospective, community-based study of long-term outcomes of childhood-onset epilepsy, we evaluated whether worse HRQOL is associated with more recent seizures among children and adolescents with epilepsy. We used the Child Health Questionnaire (CHQ), a generic measure with child and parent-proxy versions, to measure HRQOL. Among 277 children with epilepsy (CWE) assessed 9years after diagnosis, parent-proxy reported but not child self-reported HRQOL was significantly worse for those having seizures in the prior year than for those who were seizure free ≥1year across the majority of scales. There were no differences bet... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5482952 Tue, 29 Nov 2011 05:00:00 +0100 5482952 http://www.medworm.com/index.php?rid=5482956&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22119107%26dopt%3DAbstract Authors: Kariuki SM, Abubakar A, Holding PA, Mung'ala-Odera V, Chengo E, Kihara M, Neville BG, Newton CR Abstract The aims of this study were to record behavioral problems in children with epilepsy (CWE), compare the prevalence with that reported among healthy children without epilepsy, and investigate the risk factors. A child behavioral questionnaire for parents comprising 15 items was administered to the main caregiver of 108 CWE and 108 controls matched for age in Kilifi, Kenya. CWE had a higher mean score for reported behavioral problems than controls (6.9 vs 4.9, t=4.7, P<0.001). CWE with active epilepsy also recorded more behavioral problems than those with inactive epilepsy (8.2 vs 6.2, t=-2.9, P=0.005). A significantly greater proportion of CWE (49% vs 26% of controls) ... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5482956 Thu, 24 Nov 2011 05:00:00 +0100 5482956 http://www.medworm.com/index.php?rid=5482955&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22119503%26dopt%3DAbstract CONCLUSION: A high level of consensus was reached on most treatments of choice and first-line treatments for patients with epilepsy, which were in accordance with published US expert opinion. PMID: 22119503 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5482955 Wed, 23 Nov 2011 05:00:00 +0100 5482955 http://www.medworm.com/index.php?rid=5482958&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22112305%26dopt%3DAbstract CONCLUSION: Overall, a small number of PWS are disobedient and illegally driving. A targeted approach to high-risk drivers with repeated verbal and supplemental driving information may help avoid unnecessary universal physician reporting for PWS. PMID: 22112305 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5482958 Mon, 21 Nov 2011 05:00:00 +0100 5482958 http://www.medworm.com/index.php?rid=5482957&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22112306%26dopt%3DAbstract We describe a patient who presented with temporal lobe epilepsy and a seizure onset pattern in the right temporo-occipital area. Structural MRI revealed sclerosis in the right hippocampus. A comprehensive presurgical neuropsychological assessment allowed us to disentangle deficits in visual object recognition and visual imagery from well-preserved spatial capacities. Following a right temporal lobectomy, the patient remained seizure free, and 1year postsurgery, the patient's scores on object recognition and imagery were in the normal range. Our findings suggest that visual object recognition and visual imagery are sustained by cortical areas located in proximity to the temporo-occipital ventral pathway and that perceptual and imagery spatial processing is subserved as well by anatomically ... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5482957 Mon, 21 Nov 2011 05:00:00 +0100 5482957 http://www.medworm.com/index.php?rid=5482960&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22100066%26dopt%3DAbstract We examined the relationship between seizure outcomes and long-term changes in memory and intellectual function in 70 patients who had undergone temporal lobe resection for medically intractable epilepsy. Patients were assessed on four occasions: preoperatively (T1), 3months postoperatively (T2), 1year postoperatively (T3), and more than 5years postoperatively (T4). The majority of patients had stable memory function across the assessments. However, many were functioning below the 15th percentile on the test norms preoperatively, with little capacity for further decline. All patients who demonstrated a progressive decline in verbal or visual learning were female and continued to experience seizures postoperatively. Progressive postoperative declines in memory function are associated with p... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5482960 Fri, 18 Nov 2011 05:00:00 +0100 5482960 http://www.medworm.com/index.php?rid=5482961&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22100065%26dopt%3DAbstract Authors: Reinsberger C, Perez DL, Murphy MM, Dworetzky BA Abstract Psychogenic nonepileptic seizures (PNES) remain poorly understood neurobiologically. Previously reported work suggests that adjunct ictal heart rates (HRs) may differentiate PNES from complex partial seizures (CPS). We retrospectively reviewed and compared preictal, ictal, and postictal HR differences in patients with PNES (n=42) and CPS controls (n=46) electively admitted for video/EEG monitoring to further characterize PNES autonomic patterns. Statistically significant preictal HR increases (P=0.006) and postictal (P=0.015) HR reductions normalized to baseline were identified in subjects with PNES compared with CPS controls. Ictal HRs were not found to differentiate between PNES and CPS events. This pattern of pre... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5482961 Thu, 17 Nov 2011 05:00:00 +0100 5482961 http://www.medworm.com/index.php?rid=5482959&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22100067%26dopt%3DAbstract Authors: Kim HY, Kim JY, Kim GU, Han HJ, Shin DI Abstract Epilepsia partialis continua (EPC) is clinically defined as a syndrome of continuous focal jerking of a body part, usually a distal limb, occurring over hours, days, or even years. It is considered the status epilepticus equivalent of simple partial motor seizures. A 48-year-old right-handed man with a history of traumatic intracranial hemorrhage was admitted for right-sided hemiplegia and drowsiness after complex partial status epilepticus. An EEG showed periodic lateralized epileptiform discharges over the left hemisphere. Brain MRI revealed extensive multifocal encephalomalaciac changes in the left temporo-parieto-occpital lobe and both frontal lobes with some hemorrhagic residual change. After administration of a loading... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5482959 Thu, 17 Nov 2011 05:00:00 +0100 5482959 http://www.medworm.com/index.php?rid=5482992&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22099526%26dopt%3DAbstract CONCLUSION: This study suggests that the developmental course of patients with TSC may be altered by epilepsy comorbidity and neurosurgery, underlining the need for early and effective interventions in this population. PMID: 22099526 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5482992 Wed, 16 Nov 2011 05:00:00 +0100 5482992 http://www.medworm.com/index.php?rid=5482963&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22099527%26dopt%3DAbstract Authors: Butler T, Blackmon K, McDonald CR, Carlson C, Barr WB, Devinsky O, Kuzniecky R, Dubois J, French J, Halgren E, Thesen T Abstract Depression in patients with temporal lobe epilepsy (TLE) is highly prevalent and carries significant morbidity and mortality. Its neural basis is poorly understood. We used quantitative, surface-based MRI analysis to correlate brain morphometry with severity of depressive symptoms in 38 patients with TLE and 45 controls. Increasing severity of depressive symptoms was associated with orbitofrontal cortex (OFC) thinning in controls, but with OFC thickening in TLE patients. These results demonstrate distinct neuroanatomical substrates for depression with and without TLE, and suggest a unique role for OFC, a limbic region for emotional processing str... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5482963 Wed, 16 Nov 2011 05:00:00 +0100 5482963 http://www.medworm.com/index.php?rid=5482962&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22099528%26dopt%3DAbstract Authors: Wicks P, Keininger DL, Massagli MP, la Loge CD, Brownstein C, Isojärvi J, Heywood J Abstract An epilepsy community was developed on PatientsLikeMe.com to share data between patients to improve their outcomes by finding other patients like them. In a 14-day response period, 221 patients with epilepsy (mean age: 40years, SD: 12, range: 17-72, 66% female) completed a survey about benefits they perceived. Prior to using the site, a third of respondents (30%) did not know anyone else with epilepsy with whom they could talk; of these, 63% now had at least one other patient with whom they could connect. Perceived benefits included: finding another patient experiencing the same symptoms (59%), gaining a better understanding of seizures (58%), and learning more about symptoms or t... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5482962 Wed, 16 Nov 2011 05:00:00 +0100 5482962 http://www.medworm.com/index.php?rid=5429053&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22093246%26dopt%3DAbstract Authors: Razvi S, Mulhern S, Duncan R Abstract Patients with psychogenic nonepileptic seizures (PNES) are heavy users of emergency and nonemergency health care. We performed a 1-year prospective audit of use of a group of PNES-related health care items in patients with newly diagnosed (mean duration: 7.3months) PNES from PNES onset to diagnosis and from diagnosis to 6months postdiagnosis. Twenty-eight patients (20 women, age: 34±16years) were responsible for 14 general practitioner home visits, 31 ambulance calls, 34 emergency department visits, 21 hospital admissions (66 inpatient days), 8 MRI scans, 24 CT scans, 2 standard EEGs, 28 short video EEG recordings, and 5 ambulatory EEG recordings. In the 6months following diagnosis, there were 2 emergency department visits (94.1% redu... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5429053 Tue, 15 Nov 2011 05:00:00 +0100 5429053 http://www.medworm.com/index.php?rid=5429052&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22093247%26dopt%3DAbstract Authors: Ferro MA, Speechley KN PMID: 22093247 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5429052 Tue, 15 Nov 2011 05:00:00 +0100 5429052 http://www.medworm.com/index.php?rid=5429054&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22088487%26dopt%3DAbstract Authors: Lathers CM, Koehler SA, Wecht CH, Schraeder PL Abstract A 1-year retrospective coroner-based forensic examination of causes of death among persons with a history of epilepsy was conducted at the Allegheny County Coroner's Office to evaluate the phenomenon of sudden unexplained/unexpected death in epilepsy (SUDEP), a diagnosis of exclusion. All cases at the Coroner's Office from January 1, 2001 through December 31, 2001, were examined. Review of a total of 1200 autopsied deaths revealed 12 cases with a past medical history of seizure disorder on the death certificate, which listed seizure disorder as the immediate cause of death or contributory cause of the death. Of the 7 men with seizure disorders, 5 were categorized as definite SUDEP and 2 as possible SUDEP. Of the 5 wom... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5429054 Mon, 14 Nov 2011 05:00:00 +0100 5429054 http://www.medworm.com/index.php?rid=5429057&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22079436%26dopt%3DAbstract We describe two cases of focal symptomatic drug-resistant epilepsy with headache as the first ictal symptom. In both cases, the headache, which lasted a few seconds, was contralateral to the ictal discharge and did not have the clinical features of migraine. Ictal headache is a rare epilepsy symptom that can help to localize ictal EEG discharges. Recently, the term ictal epileptic headache has been proposed in cases in which headache is the sole ictal epileptic manifestation Diagnosis requires the simultaneous onset of headache with EEG-demonstrated ictal discharges. PMID: 22079436 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5429057 Fri, 11 Nov 2011 05:00:00 +0100 5429057 http://www.medworm.com/index.php?rid=5429056&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22079437%26dopt%3DAbstract Authors: Li N, Chen G, Song X, Du W, Zheng X Abstract Few articles in English have discussed the prevalence of autism in China. The work described here was aimed at estimating the prevalence rate of autism-caused disability among Chinese children and exploring family environmental factors associated with autism based on a national population sample. Data for this study were derived from the Second China National Sample Survey on Disability. A weighted number of 77,301 disabled children affected by autism were identified, yielding a prevalence rate of 2.38/10,000. A history of mental disorders in adults was strongly associated with autism. The prevalence of autism in Chinese children was underestimated, and the lack of qualified professionals able to identify and diagnose autism was... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5429056 Fri, 11 Nov 2011 05:00:00 +0100 5429056 http://www.medworm.com/index.php?rid=5429055&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22079438%26dopt%3DAbstract Authors: Cavanna AE, Rickards H, Ali F Abstract The assessment of ictal consciousness has been the landmark criterion for the differentiation between simple and complex partial seizures over the last three decades. After review of the historical development of the concept of "complex partial seizure," the difficulties surrounding the simple versus complex dichotomy are addressed from theoretical, phenomenological, and neurophysiological standpoints. With respect to consciousness, careful analysis of ictal semiology shows that both the general level of vigilance and the specific contents of the conscious state can be selectively involved during partial seizures. Moreover, recent neuroimaging findings, coupled with classic electrophysiological studies, suggest that the neural substra... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5429055 Fri, 11 Nov 2011 05:00:00 +0100 5429055 http://www.medworm.com/index.php?rid=5383976&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22056814%26dopt%3DAbstract Authors: Elsas SM, Gregory WL, White G, Navarro G, Salinsky MC, Andrews DJ Abstract Patients with epilepsy frequently experience depression and emotional stress and these may function as seizure triggers in epileptogenic frontotemporal cortex, which serves in emotional processing. Eight patients enrolled in a pilot trial of a 6-month epilepsy-specific behavioral approach comprising counseling and relaxation to recognize and eliminate emotional seizure triggers. Potential participants with psychogenic seizures were excluded by long-term EEG and/or the MMPI profile. One participant became seizure free, another had an approximately 90% reduction in seizures, and two additional participants achieved a greater than 50% reduction in seizure frequency (total responder rate=50%), stable du... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5383976 Sat, 05 Nov 2011 04:00:00 +0100 5383976 http://www.medworm.com/index.php?rid=5383975&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22056815%26dopt%3DAbstract Authors: Calabrò RS PMID: 22056815 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5383975 Fri, 04 Nov 2011 04:00:00 +0100 5383975 http://www.medworm.com/index.php?rid=5383978&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22056341%26dopt%3DAbstract Authors: da Costa JS, de Almeida AA, Tomé AD, Citó AM, Saffi J, de Freitas RM Abstract The aim of present study was to examine the effects of the ethyl acetate fraction (EAF) from Platonia insignis on lipid peroxidation level, nitrite formation, and superoxide dismutase and catalase activities in rat striatum prior to pilocarpine-induced seizures as well as to explore its anticonvulsant activity in adult rats prior to pentylenetetrazole (PTZ)- and picrotoxin (PIC)-induced seizures. Wistar rats were treated with vehicle, atropine (25mg/kg), EAF (0.1, 1, and 10mg/kg), pilocarpine (400mg/kg, P400 group), PTZ (60mg/kg, PTZ group), PIC (8mg/kg, PIC group), atropine+P400, EAF+P400, EAF+PTZ, or EAF+PIC. Significant decreases in number of crossings and rearings were observed in the P400 ... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5383978 Thu, 03 Nov 2011 04:00:00 +0100 5383978 http://www.medworm.com/index.php?rid=5383977&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22056342%26dopt%3DAbstract Authors: Ghasemi M, Schachter SC Abstract A substantial amount of research has shown that N-methyl-D-aspartate receptors (NMDARs) may play a key role in the pathophysiology of several neurological diseases, including epilepsy. Animal models of epilepsy and clinical studies demonstrate that NMDAR activity and expression can be altered in association with epilepsy and particularly in some specific seizure types. NMDAR antagonists have been shown to have antiepileptic effects in both clinical and preclinical studies. There is some evidence that conventional antiepileptic drugs may also affect NMDAR function. In this review, we describe the evidence for the involvement of NMDARs in the pathophysiology of epilepsy and provide an overview of NMDAR antagonists that have been investigated ... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5383977 Thu, 03 Nov 2011 04:00:00 +0100 5383977 http://www.medworm.com/index.php?rid=5383998&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21982255%26dopt%3DAbstract Authors: Rayport SM, Rayport M, Schell CA Abstract There has been considerable debate about Fyodor Dostoevsky's epilepsy. Was his epilepsy generalized or focal? Was the dramatic ecstatic experience an epileptic phenomenon or a literary invention? We compared probable epileptically related behavioral manifestations in The Idiot with experiences of current patients, studied with a modern interdisciplinary approach involving neurosurgery, neurology, and neuropsychiatry. Patients were studied by all disciplines starting with their initial evaluation and trial of antiseizure medication, during hospitalization for long-term monitoring for epilepsy at scalp and depth levels with electrical brain stimulation, during intraoperative interviews, and in long-term postoperative follow-up. Behav... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5383998 Tue, 01 Nov 2011 04:00:00 +0100 5383998 http://www.medworm.com/index.php?rid=5383979&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22040845%26dopt%3DAbstract This report describes three cases of refractory temporal lobe epilepsy and hippocampal sclerosis, which, after anterior temporal lobectomy, presented with acute psychosis. One of them had a history of acute psychosis, and all of them met criteria for Cluster A personality disorder (schizoid/schizotypal) during psychiatric assessment prior to surgery. The three cases had a good seizure outcome (Engel I), but, on follow-up during the first year after surgery, developed an acute psychotic episode compatible with schizoaffective disorder; brief psychotic disorder; and a delusional disorder, respectively, according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Treatment with low-dose risperidone was successful. PMID: 22040845 [PubMed - as supplied by publishe... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5383979 Sat, 29 Oct 2011 04:00:00 +0100 5383979 http://www.medworm.com/index.php?rid=5383980&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22037205%26dopt%3DAbstract Authors: Ali A, Ali TE, Kerr K, Ali SB Abstract There are relatively few published studies on epilepsy-related knowledge, attitudes, and practices (KAP) from developing countries and none from Jamaica. A questionnaire-based, cross-sectional study of 320 individuals was performed in a small community in Kingston. Residents and employees were comparable in age, sex, and personal and family history of epilepsy, but differed in attained education and occupation. Persons with postsecondary education were less likely to believe that epilepsy is a mental disorder (9% vs 24.8%, P<0.001), is due to demonic possession (8% vs 18.2%, P<0.01), or is contagious (2.5% vs 23%, P<0.001). Overall, 73% felt that people with epilepsy should not drive. The results of this Jamaican KAP study di... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5383980 Fri, 28 Oct 2011 04:00:00 +0100 5383980 http://www.medworm.com/index.php?rid=5383983&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22036287%26dopt%3DAbstract Authors: Ritaccio A, Boatman-Reich D, Brunner P, Cervenka MC, Cole AJ, Crone N, Duckrow R, Korzeniewska A, Litt B, Miller KJ, Moran DW, Parvizi J, Viventi J, Williams J, Schalk G Abstract The Second International Workshop on Advances in Electrocorticography (ECoG) was convened in San Diego, CA, USA, on November 11-12, 2010. Between this meeting and the inaugural 2009 event, a much clearer picture has been emerging of cortical ECoG physiology and its relationship to local field potentials and single-cell recordings. Innovations in material engineering are advancing the goal of a stable long-term recording interface. Continued evolution of ECoG-driven brain-computer interface technology is determining innovation in neuroprosthetics. Improvements in instrumentation and statistical met... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5383983 Thu, 27 Oct 2011 04:00:00 +0100 5383983 http://www.medworm.com/index.php?rid=5383982&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22036465%26dopt%3DAbstract Authors: Tawfik MK Abstract Conventional antiepileptic drugs fail to adequately control seizures and predispose to cognitive impairment and oxidative stress with chronic usage in a significant proportion of patients with epilepsy. Coenzyme Q10 (CoQ10), an antioxidant compound, exhibits a wide range of therapeutic effects that are attributed to its potent antioxidant capacity. To evaluate the neuroprotective effects of CoQ10 in rats against the observed oxidative stress during seizures induced by pilocarpine, and to study its interactions with the conventional antiepileptic drug phenytoin, two experiments were performed. Experiment 1 was conducted to test the effect of phenytoin, CoQ10, or both on seizure severity and oxidative markers in the pilocarpine model of epilepsy. Experimen... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5383982 Wed, 26 Oct 2011 04:00:00 +0100 5383982 http://www.medworm.com/index.php?rid=5383981&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22036466%26dopt%3DAbstract Authors: Liava A PMID: 22036466 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5383981 Wed, 26 Oct 2011 04:00:00 +0100 5383981 http://www.medworm.com/index.php?rid=5383984&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22032959%26dopt%3DAbstract Authors: Mendonça P, Arida RM, Cavalheiro EA, Scorza FA PMID: 22032959 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5383984 Tue, 25 Oct 2011 04:00:00 +0100 5383984 http://www.medworm.com/index.php?rid=5383986&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22030535%26dopt%3DAbstract We describe a 19-year-old female patient who had been referred to the psychiatric unit because of behavioral disorders characterized predominantly by delirium with sexual content. She developed recurrent focal seizures characterized by atypical ictal semiology (repetitive forceful yawning) and a rare EEG pattern (recurrent seizures arising from the left temporal region without evident "encephalopathic" activity). The presence of anti-thyroperoxidase antibodies in her cerebrospinal fluid and a good response to steroids confirmed the diagnosis of HE. The atypical presentation in the case we describe appears to widen the electroclinical spectrum of HE and highlights its importance for differential diagnosis purposes in the neuropsychiatric setting. PMID: 22030535 [PubMed - as supplied by ... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5383986 Mon, 24 Oct 2011 04:00:00 +0100 5383986 http://www.medworm.com/index.php?rid=5383985&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22030536%26dopt%3DAbstract Authors: Miatton M, Van Roost D, Thiery E, Carrette E, Van Dycke A, Vonck K, Meurs A, Vingerhoets G, Boon P Abstract The aim of this study was to examine the effects of amygdalohippocampal deep brain stimulation (AH-DBS) on cognitive functioning in patients with refractory temporal lobe epilepsy. The population consisted of 10 patients (7 men) who underwent ipsilateral (n=8) or bilateral (n=2) AH-DBS. Intellectual and neuropsychological evaluation was performed before and 6months after initiation of AH-DBS. Group analyses revealed no overall pattern of change in cognitive measures, but improvement was seen in emotional well-being. Individual results varied over a broad spectrum ranging from no cognitive effects to negative effects on intelligence capacities, divided attention, and ... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5383985 Mon, 24 Oct 2011 04:00:00 +0100 5383985 http://www.medworm.com/index.php?rid=5383994&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22018800%26dopt%3DAbstract CONCLUSION: Depression has a major influence on suicidality in epilepsy. Motor impulsivity is also relevant and may be an important component of depression in TLE associated with suicide risk. PMID: 22018800 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5383994 Thu, 20 Oct 2011 04:00:00 +0100 5383994 http://www.medworm.com/index.php?rid=5383993&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22018801%26dopt%3DAbstract We describe the case of a 74-year-old man with left parietal arteriovenous malformation (AVM) and cerebral white matter radiation necrosis who developed persistent subjective right-sided groin pulsations. The EEG revealed left parietal periodic lateralized epileptiform discharges (PLEDs) time-locked to these sensations, confirming that the patient's symptoms represented sensory seizures with ictal PLEDs as the electrographic correlate. To our knowledge, this is the first reported case of ictal PLEDs manifesting as sensory seizures. PMID: 22018801 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5383993 Thu, 20 Oct 2011 04:00:00 +0100 5383993 http://www.medworm.com/index.php?rid=5383992&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22019015%26dopt%3DAbstract Authors: Wang WH, Liou HH, Chen CC, Chiu MJ, Chen TF, Cheng TW, Hua MS Abstract The aim of this study was to identify the neuropsychological features in patients with temporal lobe epilepsy (TLE) and their correlation with seizure-related variables. For this purpose, we carried out a retrospective analysis of data from 65 patients with TLE who had undergone a comprehensive neuropsychological assessment. The results suggest that the majority of patients with TLE were impaired in more than one cognitive domain, and among these patients, the mean proportions with defective semantic memory, language, motor/psychomotor speed, verbal episodic memory, and executive function were >50% each. Moreover, age at seizure onset was the strongest predictor of general intellectual impairment, an... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5383992 Wed, 19 Oct 2011 04:00:00 +0100 5383992 http://www.medworm.com/index.php?rid=5383991&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22019016%26dopt%3DAbstract In this study people with a diagnosis of epilepsy recruited from primary care were mailed a questionnaire covering help seeking for psychological distress, treatment preferences for depression, and current symptoms of depression using the Patient Health Questionnaire-2 (PHQ2). Eighty-six people with epilepsy responded to the survey and 44% of the sample reported they would not seek help if they were feeling stressed, worried, or low and it was affecting their daily lives. Almost 40% of the participants screened positive for current depression and PHQ2 scores were statistically unchanged over an average of 8.6months. The most popular treatment for depression was advice from a general practitioner or from family and friends. The majority of respondents felt speed of treatment should take pri... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5383991 Wed, 19 Oct 2011 04:00:00 +0100 5383991 http://www.medworm.com/index.php?rid=5383990&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22019017%26dopt%3DAbstract Authors: Fisher RS PMID: 22019017 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5383990 Wed, 19 Oct 2011 04:00:00 +0100 5383990 http://www.medworm.com/index.php?rid=5383989&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22019018%26dopt%3DAbstract CONCLUSIONS: Optimizing quality of life in patients with epilepsy requires an approach that extends beyond controlling seizures. Collection of validated health status measures improving patient management is possible within the setting of routine clinical care. PMID: 22019018 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5383989 Wed, 19 Oct 2011 04:00:00 +0100 5383989 http://www.medworm.com/index.php?rid=5383988&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22019019%26dopt%3DAbstract Authors: Akahoshi N, Ishizaki Y, Yasuda H, Murashima YL, Shinba T, Goto K, Himi T, Chun J, Ishii I Abstract The diverse physiological effects of sphingosine 1-phosphate (S1P) are mostly mediated by its five cognate G protein-coupled receptors, S1P(1)-S1P(5), which have attracted much attention as future drug targets. To gain insight into S1P(2)-mediated signaling, we analyzed frequent spontaneous seizures in S1P(2)-deficient (S1P(2)(-/-)) mice obtained after several backcrosses onto a C57BL/6N background. Full-time video recording of 20 S1P(2)(-/-) mice identified 420 seizures both day and night between postnatal days 25 and 45, which were accompanied by high-voltage synchronized cortical discharges and a series of typical episodes: wild run, tonic-clonic convulsion, freezing, and,... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5383988 Wed, 19 Oct 2011 04:00:00 +0100 5383988 http://www.medworm.com/index.php?rid=5383987&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22019020%26dopt%3DAbstract CONCLUSIONS: Cognitive decline has a heavy impact on young adults with intractable epilepsy. In contrast to seizures, the cognitive decline is persistent. The themes reflected different hardships faced by the participants. The consequences of living with epilepsy and cognitive impairment concerned education, employment, social life, self-esteem, and hope for the future. The participants were already using strategies to cope with their cognitive decline, but may benefit from help in developing new strategies to better adjust to their memory problems. Development of more educational programs for both people with epilepsy and their relatives could improve their difficult situations. With help, people can learn to adjust their goals in life and live a fulfilling life despite the disease. P... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5383987 Wed, 19 Oct 2011 04:00:00 +0100 5383987 http://www.medworm.com/index.php?rid=5383996&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22015212%26dopt%3DAbstract We describe a case of a patient with TLE who showed improvement in ALF and in remote memory impairment after an anterior left temporal pole lobectomy including the uncus and amygdala. Our findings confirm that impairment of hippocampal functioning leads to pathological ALF, whereas restoration of hippocampal functioning brings ALF to a level comparable to that of controls. PMID: 22015212 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5383996 Tue, 18 Oct 2011 04:00:00 +0100 5383996 http://www.medworm.com/index.php?rid=5383995&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22015213%26dopt%3DAbstract Authors: Fazan R, de Oliveira M, Oliveira JA, Salgado HC, Garcia-Cairasco N Abstract We evaluated autonomic cardiovascular modulation and baroreflex control of heart rate (HR) in a particular epileptic rat strain, Wistar audiogenic rats (WARs). We studied spontaneous baroreflex sensitivity as well as reflex changes in HR evoked by phenylephrine/nitroprusside-induced changes in arterial pressure (AP). Atropine and propranolol were used to measure cardiac autonomic tone. AP and pulse interval (PI) variability analysis were performed in the time and frequency domains (FFT spectral analysis) to evaluate cardiovascular sympatovagal modulation in WARs. AP and HR were higher in WARs (109±2mm Hg and 366±9bpm) than in Wistar control rats (101±2mm Hg and 326±10bpm). The power of the low-... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5383995 Tue, 18 Oct 2011 04:00:00 +0100 5383995 http://www.medworm.com/index.php?rid=5383997&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21985960%26dopt%3DAbstract Authors: de Lima C, Vancini RL, Arida RM, Guilhoto LM, de Mello MT, Barreto AT, Guaranha MS, Yacubian EM, Tufik S Abstract Although the available evidence suggests that exercise may positively affect epilepsy, whether this effect is applicable to different types of epilepsy has not been established. Physiological responses during rest, acute physical effort, and a recovery period were studied by concomitant analysis of cerebral electric activity using EEGs in subjects with juvenile myoclonic epilepsy (JME) and healthy controls. In addition, level of habitual physical activity, body composition, and 1week of actigraphy monitoring data were evaluated. Twenty-four subjects (12 with JME and 12 controls) participated in this study. Compared with the control group, the JME group had a si... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5383997 Sat, 08 Oct 2011 04:00:00 +0100 5383997 http://www.medworm.com/index.php?rid=5383999&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21978471%26dopt%3DAbstract Authors: Pellock JM, Faught E, Sergott RC, Shields WD, Burkhart GA, Krauss GL, Foroozan R, Wesche DL, Weinberg MA Abstract The vigabatrin patient registry was implemented in August 2009 in conjunction with Food and Drug Administration approval of vigabatrin. All US vigabatrin-treated patients must enroll in the registry. Data on prescriber specialty/location, patient demographics, and clinical characteristics are collected. Benefit-risk assessments are required early in the course of therapy. Vision assessments are required at baseline (≤4weeks after therapy initiation), every 3months during therapy, and 3 to 6months after discontinuation. As of February 1, 2011, 2473 patients (1500 with infantile spasms, 846 with refractory complex partial seizures, 120 with other diagnoses) had... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5383999 Wed, 05 Oct 2011 04:00:00 +0100 5383999 http://www.medworm.com/index.php?rid=5384000&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21978470%26dopt%3DAbstract Authors: Yonekawa T, Nakagawa E, Takeshita E, Inoue Y, Inagaki M, Kaga M, Sugai K, Sasaki M, Kaido T, Takahashi A, Otsuki T Abstract To evaluate the effect of corpus callosotomy (CC) on attention deficit and behavioral problems in pediatric patients with intractable epilepsy, we retrospectively investigated sequential patients who had undergone CC to control seizures. Between August 2005 and April 2010, a total of 15 patients aged between 3.1 and 17.9 years underwent CC at our institute. All the patients experienced either drop attacks or head nodding, which were considered to be therapeutic targets of CC. A standardized instrument, the Child Behavior Checklist (CBCL), was used to assess behavioral and emotional problems before and after surgery. On postoperative EEGs, 8 (53%) show... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5384000 Tue, 04 Oct 2011 04:00:00 +0100 5384000 http://www.medworm.com/index.php?rid=5384002&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21975298%26dopt%3DAbstract Authors: Le S, Shafer PO, Bartfeld E, Fisher RS Abstract My Epilepsy Diary is a free Web-based application on the public website epilepsy.com, available for patients to track epilepsy and to aid clinicians with data-based, individualized management. The first aim of this descriptive study was to outline electronic diary functions. Second, the study retrospectively profiled a large cohort of 2010 calendar year diary users including demographics, seizure types, temporal distribution of seizures, triggers, and use and side effects of antiepileptic drugs (AEDs). A total of 1944 users provided demographic information and 1877 recorded seizure data. Most (64%) users were women. Average age was 29.9±16.0years. A total of 70,990 seizure entries and 15,630 AED entries were logged. Events w... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5384002 Mon, 03 Oct 2011 04:00:00 +0100 5384002 http://www.medworm.com/index.php?rid=5384001&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21975299%26dopt%3DAbstract Authors: Ponnusamy A, Marques JL, Reuber M Abstract Heart rate variability (HRV) metrics provide reliable information about the functioning of the autonomic nervous system (ANS) and have been discussed as biomarkers in anxiety and personality disorders. We wanted to explore the potential of various HRV metrics (VLF, LF, HF, SDNN, RMSSD, cardiovagal index, cardiosympathetic index, approximate entropy) as biomarkers in patients with psychogenic nonepileptic seizures (PNES). HRV parameters were extracted from 3-minute resting single-lead ECGs of 129 subjects (52 with PNES, 42 with refractory epilepsy and 35 age-matched healthy controls). Compared with healthy controls, both patient groups had reduced HRV (all measures P<0.03). Binary logistic regression analyses yielded significant... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5384001 Mon, 03 Oct 2011 04:00:00 +0100 5384001 http://www.medworm.com/index.php?rid=5284908&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21775214%26dopt%3DAbstract Authors: Owczarek K PMID: 21775214 [PubMed - in process] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5284908 Sat, 01 Oct 2011 04:00:00 +0100 5284908 http://www.medworm.com/index.php?rid=5284889&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21967731%26dopt%3DAbstract Authors: Stern JM, Labiner DM, Gilliam FG, Penovich PE, Onofrey M, Eagan CA, Holmes GL Abstract Research was conducted to evaluate conversations about epilepsy between community-based neurologists and patients. Adverse effects of antiepileptic drugs and mood/behavioral issues were infrequently discussed, and neurologists and patients disagreed about these issues postvisit. Follow-up research was conducted to assess the impact of a previsit assessment tool on discussions of epilepsy. Twenty neurologists reviewed a tool incorporating questions from validated instruments (Adverse Events Profile [AEP] and Neurological Disorders Depression Inventory for Epilepsy [NDDI-E]). Naturally occurring interactions between neurologists and 60 patients were recorded. Neurologists and patients were... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5284889 Sat, 01 Oct 2011 04:00:00 +0100 5284889 http://www.medworm.com/index.php?rid=5284890&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21964448%26dopt%3DAbstract Authors: Yue L, Yu PM, Zhao DH, Wu DY, Zhu GX, Wu XY, Hong Z Abstract Improving the patient's quality of life (QOL) is the most important goal of epilepsy management. We performed this study to determine the factors associated with QOL in people with epilepsy and to assess whether there are gender differences in these determinants. Patients were interviewed using the Quality of Life in Epilepsy Inventory-31(QOLIE-31), the Adverse Event Profile (AEP), the Self-Rating Anxiety Scale (SAS), and the Hamilton Depression Rating Scale (HAMD). Two hundred forty-seven patients (152 men, 95 women) were included in the analysis. Among all patients, regressive analyses showed that AEP score was the strongest predictor of the QOLIE-31 overall score, accounting for 10.4% of the variance. The next... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5284890 Fri, 30 Sep 2011 04:00:00 +0100 5284890 http://www.medworm.com/index.php?rid=5284895&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21962755%26dopt%3DAbstract Authors: Hingray C, Maillard L, Hubsch C, Vignal JP, Bourgognon F, Laprevote V, Lerond J, Vespignani H, Schwan R Abstract This prospective study investigated and compared psychiatric features of 25 consecutive patients with psychogenic nonepileptic seizures (PNES) on the basis of presence of reported trauma. The "trauma" group comprised 19 patients (76%) and the "no-trauma" group comprised 6 patients (34%). We compared history of PNES, psychiatric comorbidity, alexithymia, and symptoms of dissociation. The study clearly characterized two distinct profiles of patients with PNES on the basis of trauma history. Patients with trauma had at least one psychiatric comorbidity or antecedent (vs 0% in the no-trauma group NT, P<0.001) and a higher median score of dissociation (P<0.001)... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5284895 Thu, 29 Sep 2011 04:00:00 +0100 5284895 http://www.medworm.com/index.php?rid=5284894&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21962756%26dopt%3DAbstract "MRI-negative PET-positive" temporal lobe epilepsy: Invasive EEG findings, histopathology, and postoperative outcomes. Epilepsy Behav. 2011 Sep 29; Authors: Kuba R, Tyrlíková I, Chrastina J, Slaná B, Pažourková M, Hemza J, Brázdil M, Novák Z, Hermanová M, Rektor I Abstract The aim of this retrospective study was to analyze invasive EEG findings, histopathology, and postoperative outcomes in patients with MRI-negative, PET-positive temporal lobe epilepsy (TLE) (MRI-/PET+TLE) who had undergone epilepsy surgery. We identified 20 patients with MRI-/PET+TLE (8.4% of all patients with TLE who had undergone surgery; 11 men, 9 women). Of the 20 patients, 16 underwent invasive EEG. The temporal pole and hippocampus were involved in the seizure onset zone in 62.5% of the pati... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5284894 Thu, 29 Sep 2011 04:00:00 +0100 5284894 http://www.medworm.com/index.php?rid=5284893&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21962757%26dopt%3DAbstract Authors: Vermoesen K, Serruys AS, Loyens E, Afrikanova T, Massie A, Schallier A, Michotte Y, Crawford AD, Esguerra CV, de Witte PA, Smolders I, Clinckers R Abstract In the past, antidepressants have been thought to possess proconvulsant properties. This assumption remains controversial, however, because anticonvulsant effects have been attributed to certain antidepressants. To date, it remains unclear which antidepressants can be used for the treatment of patients with epilepsy with depression. The present study was designed to determine the anticonvulsant and/or proconvulsant effects of three antidepressants (citalopram, reboxetine, bupropion) against pilocarpine- and pentylenetetrazole-induced acute seizures in larval zebrafish and mice. In zebrafish, all antidepressants were ant... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5284893 Thu, 29 Sep 2011 04:00:00 +0100 5284893 http://www.medworm.com/index.php?rid=5284892&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21962950%26dopt%3DAbstract Authors: Hillenbrand B, Wisniewski I, Jürges U, Steinhoff BJ Abstract We performed a retrospective study in patients with poorly controlled epilepsy treated with add-on lacosamide (LCM) to investigate the relationship of LCM-related adverse events with LCM serum concentration and weight-dependent dosage. We collected serum concentrations, weight-related dosages, and occurrences of the seven most frequent adverse events according to the randomized double-blind, placebo-controlled trials. Seventy of 131 patients could be sufficiently evaluated. LCM serum concentrations and weight-related dosages in patients with and without typical adverse events did not differ significantly. Closer analysis of the data suggested that dizziness as the leading adverse event occurred significantly mor... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5284892 Wed, 28 Sep 2011 04:00:00 +0100 5284892 http://www.medworm.com/index.php?rid=5284891&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21962951%26dopt%3DAbstract Authors: Perry MS, Swint C, Hawley J, Kohler S, Blake S, Rask K, Sladky J, Krawiecki N Abstract We sought to identify and quantify caregiver-defined characteristics of efficacy related to the perceived success of antiepileptic drug (AED) use. A 22-question survey was designed using physician input, focus groups, and clinical trial endpoints. Responses were pooled and analyzed with regard to seizure type and treatment, categorized as controlled (exposure to 1 AED), adjunctive (exposure to 2 AEDs), or refractory (exposure to ≥3 AEDs). Two hundred ninety-five surveys were completed: 109 (37%) controlled, 84 (28%) adjunctive, and 102 (35%) refractory. Seizure freedom and median seizure reduction >90% maintained for >1year were reported as the most important indicators of medica... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5284891 Wed, 28 Sep 2011 04:00:00 +0100 5284891 http://www.medworm.com/index.php?rid=5284910&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21959082%26dopt%3DAbstract Authors: Pessah N, Yagen B, Hen N, Shimshoni JA, Wlodarczyk B, Finnell RH, Bialer M Abstract A series of glycinamide conjugates and N-methoxy amide derivatives of valproic acid (VPA) analogs and constitutional isomers were synthesized and evaluated for anticonvulsant activity. Of all compounds synthesized and tested, only N-methoxy-valnoctamide (N-methoxy-VCD) possessed better activity than VPA in the following anticonvulsant tests: maximal electroshock, subcutaneous metrazol, and 6-Hz (32-mA) seizure tests. In mice, the ED(50) values of N-methoxy-VCD were 142mg/kg (maximal electroshock test), 70mg/kg (subcutaneous metrazol test), and 35mg/kg (6-Hz test), and its neurotoxicity TD(50) was 118mg/kg. In rats, the ED(50) of N-methoxy-VCD in the subcutaneous metrazol test was 36mg/kg an... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5284910 Tue, 27 Sep 2011 04:00:00 +0100 5284910 http://www.medworm.com/index.php?rid=5284909&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21959083%26dopt%3DAbstract We report in detail the safety of external TNS (eTNS), focusing on acute and long-term heart rate and systolic and diastolic blood pressure in response to TNS from the pilot feasibility study. The data indicate that eTNS of the infraorbital and supraorbital branches of the trigeminal nerve is safe and well tolerated. PMID: 21959083 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5284909 Tue, 27 Sep 2011 04:00:00 +0100 5284909 http://www.medworm.com/index.php?rid=5269012&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21945412%26dopt%3DAbstract We report a case of off-label gabapentin use masking ictal electrographic activity, the neuropsychiatric and electrographic consequences of discontinuing gabapentin, and the therapeutic response when gabapentin was re-initiated and titrated to a total daily dose greater than that at time of admission. Weaning from AEDs with concurrent video/EEG monitoring is an important diagnostic tool in these complex cases. PMID: 21945412 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5269012 Fri, 23 Sep 2011 04:00:00 +0100 5269012 http://www.medworm.com/index.php?rid=5269013&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21944062%26dopt%3DAbstract We report successful magnetoencephalography (MEG) recording in a child who had generalized epileptic spasms (ESs) as well as ESs involving the legs only during the recording. MEG source localization results demonstrated that (1) the interictal epileptiform discharges and both types of ESs had the same origin, that is, the right parietal region, and (2) the two types of ESs had different cortical spread patterns, that is, epileptic involvement localized to the right parietal region in spasms of the legs and rapid diffuse involvement in generalized spasms. In this case, MEG provided new insight into the mechanisms underlying the two types of ESs: both types were generated from the same focus, and in generalized ESs, abnormal excitation spread to cortical areas diffusely. PMID: 21944062 [... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5269013 Wed, 21 Sep 2011 04:00:00 +0100 5269013 http://www.medworm.com/index.php?rid=5269014&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21940218%26dopt%3DAbstract CONCLUSIONS: Reading performance is impaired in children with rolandic epilepsy and is correlated with the amount of nocturnal epileptiform activity. PMID: 21940218 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5269014 Tue, 20 Sep 2011 04:00:00 +0100 5269014 http://www.medworm.com/index.php?rid=5269015&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21937281%26dopt%3DAbstract CONCLUSION: Reading performance is impaired in children with rolandic epilepsy. Reading of sentences is more impaired than reading of words. There is a significant correlation between problems in motor development and language, suggesting their interaction at the level of the cortex. PMID: 21937281 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5269015 Mon, 19 Sep 2011 04:00:00 +0100 5269015 http://www.medworm.com/index.php?rid=5269017&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21930433%26dopt%3DAbstract Authors: Choi H, Pargeon K, Bausell R, Wong JB, Mendiratta A, Bakken S Abstract Patients with pharmacoresistant temporal lobe epilepsy (TLE) contemplating brain surgery must make a complex treatment decision involving trade-offs. Patient decision aids, containing information on the risks and benefits of treatment interventions, increase patient knowledge and facilitate shared decision making between patients and physicians. We conducted five focus groups to describe the information patients need to make informed decisions about TLE surgery. Twenty patients who had undergone TLE surgery described the information used in their decision-making process, and evaluated the potential for a patient decision aid to assist other patients who are considering surgery. Thematic analysis reveale... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5269017 Sat, 17 Sep 2011 04:00:00 +0100 5269017 http://www.medworm.com/index.php?rid=5269016&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21930434%26dopt%3DAbstract Authors: Hermann B PMID: 21930434 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5269016 Sat, 17 Sep 2011 04:00:00 +0100 5269016 http://www.medworm.com/index.php?rid=5235887&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21924684%26dopt%3DAbstract Authors: Rolland B, Karila L, Geoffroy PA, Cottencin O Abstract Cocaine-induced seizures (CIS) and cocaine-induced psychosis (CIP) may be complications of acute cocaine intoxication. CIS could result from a kindling process, involving the glutamate NMDA receptor (NMDAR) phosphorylation state, which is enhanced by activation of the dopamine D1 receptor (D1R). CIP is considered to be more specifically associated with the activity of the dopamine D2 receptor (D2R). The authors describe the case of a 21-year-old woman who presented with recurrent CIP during a period of increased cocaine abuse that ended in two consecutive CIS. This case report may illustrate a possible overlap in the mechanisms underlying CIS and CIP, disclosing some subtle interactions occurring between dopaminergic a... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5235887 Wed, 14 Sep 2011 04:00:00 +0100 5235887 http://www.medworm.com/index.php?rid=5235888&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21920823%26dopt%3DAbstract We report the video/EEG documentation of yawning as an ictal sign in a 31-year-old patient affected by drug-resistant focal epilepsy symptomatic of bilateral perisylvian polymicrogyria. Since the age of 10 she has had seizures characterized by yawning, staring, and eye blinking. Bilateral rhythmic frontotemporal spikes and waves characterized her EEG. We reviewed all reported cases and compared clinical and EEG features. We believe that yawning as part of an epileptic seizure might be considered a rare automatic behavior, like other automatisms frequently reported in epileptic seizures. Automatisms are more frequently described in patients with temporal lobe epilepsy, and involvement of the temporal lobe in most of the published cases may have led to this explanation. It is possible that y... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5235888 Tue, 13 Sep 2011 04:00:00 +0100 5235888 http://www.medworm.com/index.php?rid=5235889&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21917527%26dopt%3DAbstract This study demonstrated the influence of seizure frequency on cardiac autonomic modulation, providing a basis for discussion of potential mechanisms that cause patients with epilepsy to die suddenly. PMID: 21917527 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5235889 Mon, 12 Sep 2011 04:00:00 +0100 5235889 http://www.medworm.com/index.php?rid=5223017&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21911314%26dopt%3DAbstract Authors: Baxendale S PMID: 21911314 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5223017 Sat, 10 Sep 2011 04:00:00 +0100 5223017 http://www.medworm.com/index.php?rid=5223019&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21908236%26dopt%3DAbstract CONCLUSION: Ictal semiology may indicate the involvement of a symptomatogenic brain region during a seizure, but extent of seizure onset in central motor or sensorimotor area is not reliable enough to indicate the seizure onset zone and favorable postoperative outcome in FLE. MEG provided specific localization of epileptic activity in a FLE compartment, and indicated the relationship between epileptogenic region and lesion. MEG can complement ictal semiology in establishing a noninvasive focal localization hypothesis. PMID: 21908236 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5223019 Fri, 09 Sep 2011 04:00:00 +0100 5223019 http://www.medworm.com/index.php?rid=5223018&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21908237%26dopt%3DAbstract Authors: Felker MV, Walker LM, Sokol DK, Edwards-Brown M, Chang BS Abstract Adults with periventricular nodular heterotopia (PNH) have epilepsy and dyslexia, but most have normal intelligence. It is not known whether PNH-related reading difficulty can be detected earlier in childhood or whether associated behavioral problems are present. We studied 10 children with PNH, 3 of whom did not have seizures, and 10 matched controls with neuropsychological testing and parental rating instruments at two time points separated by about 1year. Children with PNH performed significantly worse than controls on a task related to reading fluency. In addition, those with PNH showed significantly worse adaptive skills, and a measure of conduct problems significantly worsened over time. Mood and beha... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5223018 Fri, 09 Sep 2011 04:00:00 +0100 5223018 http://www.medworm.com/index.php?rid=5223025&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21907625%26dopt%3DAbstract We report the results of administration of the Portuguese-Brazilian translation of the Liverpool Adverse Events Profile (LAEP) to 100 patients (mean age=34.5, SD=12.12; 56 females), 61 with symptomatic partial epilepsy (SPE) and 39 with idiopathic generalized epilepsy (IGE) (ILAE, 1989) who were on a stable antiepileptic drug (AED) regimen and being treated in a Brazilian tertiary epilepsy center. Carbamazepine was the most commonly used AED (43.0%), followed by valproic acid (32.0%). Two or more AEDs were used by 69.0% of patients. The mean LAEP score (19 questions) was 37.6 (SD=13.35). The most common adverse effects were sleepiness (35.0%), memory problems (35.0%), and difficulty in concentrating (25.0%). Higher LAEP scores were associated with polytherapy with three or more AEDs (P=0.0... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5223025 Thu, 08 Sep 2011 04:00:00 +0100 5223025 http://www.medworm.com/index.php?rid=5223024&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21907626%26dopt%3DAbstract This study investigated the validity of multiple independent self-report variables in predicting psychogenic nonepileptic versus epileptic seizures. One hundred forty-three patients with psychogenic nonepileptic seizures and 129 patients with epileptic seizures were compared with the Personality Assessment Inventory, age at seizure onset, years since first seizure, and length of seizures. Diagnostic prediction was made by analyses of variance and logistic regressions. Cut scores were developed for the multivariate predictors with maximal sensitivity and specificity. The Personality Assessment Inventory conversion subscale (SOM-C), years since first seizure, and length of seizures provided 84% correct classification. Ninety-six percent of patients meeting cut scores of SOM-C ≥70, years si... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5223024 Thu, 08 Sep 2011 04:00:00 +0100 5223024 http://www.medworm.com/index.php?rid=5223023&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21907627%26dopt%3DAbstract Authors: Nakhutina L, Gonzalez JS, Margolis SA, Spada A, Grant A Abstract The current study examined beliefs about medication and their association with adherence to antiepileptic drugs (AEDs) among predominantly ethnic minority, low-income patients with epilepsy (PWE). Seventy-two PWE completed standardized questionnaires. The Beliefs about Medicines Questionnaire was used to assess perceptions about AEDs and medications in general. Adherence was measured with the Morisky 4-item scale and via participant self-rating. On the Morisky scale, 63% of patients endorsed at least one item for nonadherence; forgetfulness was most often endorsed (50%). There was a significant relationship between seizure frequency and adherence (Morisky: r=0.33, P=0.006; self-rating: r=-0.35, P=0.003). Pati... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5223023 Thu, 08 Sep 2011 04:00:00 +0100 5223023 http://www.medworm.com/index.php?rid=5223022&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21907628%26dopt%3DAbstract Authors: Aniol VA, Stepanichev MY, Lazareva NA, Gulyaeva NV Abstract There are increasing data on the influence of seizures on neurogenesis in the adult brain. However, data on cell proliferation and differentiation during the early stages of kindling are scarce. We have used pentylenetetrazole (PTZ)-induced kindling to investigate the temporal profile of cytogenesis in the germinative zones of adult rat brain. For comparison, we also used a single PTZ-induced generalized tonic-clonic seizure. During kindling development, the density of 5-bromo-2'-deoxyuridine-positive cells demonstrated similar changes in all germinative zones: a dramatic decrease after the first subthreshold PTZ injection, and a gradual increase to the control level following repeated PTZ administration. On the c... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5223022 Thu, 08 Sep 2011 04:00:00 +0100 5223022 http://www.medworm.com/index.php?rid=5223021&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21907629%26dopt%3DAbstract We describe a case of alexia with agraphia for kanji (Japanese ideograms) caused by temporal lobe epilepsy. After generalized convulsions, a 32-year-old man noticed that he had difficulty in reading and writing kanji, although he could read and write kana (Japanese syllabograms). His EEG showed frequent sharp waves on the left occipitotemporal region. MRI of the brain revealed a hyperintense lesion on the left hippocampus. Single-photon-emission computed tomography revealed marked hyperperfusion at the left hippocampus and the left posteroinferior temporal cortex. Antiepileptic drugs improved his alexia with agraphia for kanji. This is the first report describing alexia with agraphia for kanji caused by temporal lobe epilepsy. PMID: 21907629 [PubMed - as supplied by publisher] (Source:... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5223021 Thu, 08 Sep 2011 04:00:00 +0100 5223021 http://www.medworm.com/index.php?rid=5223020&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21907630%26dopt%3DAbstract CONCLUSION: Compared with Caucasians, African-Americans have significantly poorer AED adherence, as measured by the MPR. PMID: 21907630 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5223020 Thu, 08 Sep 2011 04:00:00 +0100 5223020 http://www.medworm.com/index.php?rid=5197037&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21890417%26dopt%3DAbstract Authors: Halpern MT, Renaud JM, Vickrey BG Abstract We analyzed data from the 2002-2007 Medical Expenditure Panel Survey (MEPS) to assess whether individuals with epilepsy who are uninsured and those who have Medicaid coverage experience differences in medical resource utilization or out-of-pocket costs compared with those having other types of insurance. With sociodemographic characteristics controlled for, uninsured individuals had significantly fewer outpatient visits, fewer visits with neurologists, and greater antiepileptic drug costs than did those with private insurance. Individuals with Medicaid coverage had similar medical resource utilization rates but lower out-of-pocket costs compared with privately insured individuals. These findings indicate substantial barriers to re... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5197037 Thu, 01 Sep 2011 23:00:00 +0100 5197037 http://www.medworm.com/index.php?rid=5197036&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21890418%26dopt%3DAbstract We describe two patients with persistent fear auras after selective amygdalohippocampectomy who had to be reevaluated for a second operative procedure. In one patient, ictal SPECT revealed focal hyperperfusion within the left temporal pole. In the other patient, localization of the focus was possible with ictal scalp EEG, which revealed closely time-related focal theta activity in the right frontotemporal electrodes. Both patients underwent a second surgery leading to complete remission. The persistence of fear auras after selective amygdalohippocampectomy provides an example of involvement of a complex neuronal network in the generation of this emotional state during mesiotemporal lobe seizures. Ictal SPECT or ictal scalp EEG may be valuable in identifying the involved areas and in guidin... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5197036 Thu, 01 Sep 2011 23:00:00 +0100 5197036 http://www.medworm.com/index.php?rid=5197035&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21890419%26dopt%3DAbstract Authors: Johnson MR, Shorvon SD Abstract The genetic bases of common, nonmendelian epilepsy have been difficult to elucidate. In this article, we argue for a new approach to genetic inquiry in epilepsy. In the latter part of the 19th century, epilepsy was universally acknowledged to be part of a wider "neurological trait" that included other neuropsychiatric conditions. In recent years, studies of comorbidity have shown clear links between epilepsy and various neuropsychiatric disorders including psychosis and depression, and genetic studies of copy number variants (CNVs) have shown that in some cases, the same CNV underpins neuropsychiatric illness and epilepsy. Functional annotation analysis of the sets of genes impacted by epilepsy CNVs shows enrichment for genes involved with n... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5197035 Thu, 01 Sep 2011 23:00:00 +0100 5197035 http://www.medworm.com/index.php?rid=5197034&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21890420%26dopt%3DAbstract Authors: Tondo M, Poo P, Naudó M, Ferrando T, Genovés J, Molero M, Martorell L Abstract Epilepsy is detected in about 23% of patients with fragile X syndrome (FXS). Absence or reduced levels of the fragile X mental retardation protein (FMRP), a global regulator of translation in neurons and an important factor in synaptic plasticity, produce the observed epileptic patterns. The brain-derived neurotrophic factor (BDNF) gene is a specific regulator of synaptic plasticity, and disturbances in its function cause dendrite abnormalities similar to those observed in FXS. A putative reciprocal regulation of FMRP and BDNF has been hypothesized. The Val66Met polymorphism in the BDNF gene may be involved in the alteration of normal secretion of the mature peptide and may modulate the epilep... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5197034 Thu, 01 Sep 2011 23:00:00 +0100 5197034 http://www.medworm.com/index.php?rid=5197033&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21890421%26dopt%3DAbstract This article reports preliminary outcomes with adjunctive LCM in the everyday clinical setting. To date, 113 patients (57 males, 56 females; aged range=18-74years, median=39years) with uncontrolled partial-onset seizures (monthly frequency range=1-300, median=4) have been included in the audit. Patients were taking 1-4 (median=1) antiepileptic drugs (AEDs), having previously tried 1-12 (median 3) drug schedules. After 12weeks on stable AED dosing, LCM was added, aiming at an initial target range of 200-400mg/day. Review took place every 6-8weeks until one of four endpoints was reached: seizure freedom for ≥6months on a given LCM dose; ≥50% (responder) or <50% (marginal benefit) seizure reduction over 6months compared with baseline on the highest tolerated LCM dose; withdrawal of LCM... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5197033 Thu, 01 Sep 2011 23:00:00 +0100 5197033 http://www.medworm.com/index.php?rid=5197038&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21889913%26dopt%3DAbstract Authors: Kaplan PW Abstract There is a long-recognized association between obsessive-compulsive disorder (OCD) and chronic epilepsy, most notably refractory temporal lobe epilepsy (TLE). The literature documents this association with case reports, patient series, and some larger controlled studies that reveal that almost a quarter of patients with TLE exhibit OCD features, which may go unrecognized. Obsession features with ordering, symmetry, exactness, handwashing, and religiosity occur more often in persons with right- or left-sided epileptic foci than in those with idiopathic generalized epilepsies or controls. Neurobiological and social factors suggest abnormalities of the frontal-thalamic-pallidal-striatal-anterior cingulate-frontal circuits stemming from the observation that ... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5197038 Wed, 31 Aug 2011 23:00:00 +0100 5197038 http://www.medworm.com/index.php?rid=5197040&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21889413%26dopt%3DAbstract Authors: Diiorio C, Bamps Y, Walker ER, Escoffery C Abstract WebEase (Epilepsy Awareness, Support, and Education) is an online epilepsy self-management program to assist people with taking medication, managing stress, and improving sleep quality. The primary study aims were to determine if those who participated in WebEase demonstrated improvements in medication adherence, perceived stress, and sleep quality. Participants were randomized to a treatment (T) or waitlist control (WCL) group (n=148). At follow-up, participants in the T group reported higher levels of medication adherence than those in the WLC group. Analyses were also conducted comparing those who had completed WebEase modules with those who had not. Those who had completed at least some modules within the WebEase prog... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5197040 Tue, 30 Aug 2011 23:00:00 +0100 5197040 http://www.medworm.com/index.php?rid=5197039&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21889414%26dopt%3DAbstract We report a nineteen-year-old man with medically refractory seizures who exhibited ictal singing and laughing. He underwent intracranial stereotactic EEG recording which demonstrated ictal activity in medial and dorsolateral regions of the left frontal lobe in the generation of ictal singing. Thereafter, a left frontal resection of the superior and middle frontal gyri made him seizure-free. Among the previously reported cases of ictal singing, the symptomatogenic zones included bilateral frontal and temporal lobes. The wide variance of ictal onset zones suggests that the mechanism of ictal singing is probably related to the recruitment of music-related neural networks in different regions of both hemispheres rather than activation of a specific cortical region. PMID: 21889414 [PubMed -... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5197039 Tue, 30 Aug 2011 23:00:00 +0100 5197039 http://www.medworm.com/index.php?rid=5197041&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21885349%26dopt%3DAbstract CONCLUSION: Based on these data, it is plausible that activation of central noradrenergic and dopaminergic networks by ictal activity originating from mesial temporal structures may, under particular conditions, optimize certain complex reaction time responses. If reproduced, these findings would a force a revision of the binary tenet that seizures either degrade or spare cognitive functions and open unsuspected research vistas. PMID: 21885349 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5197041 Mon, 29 Aug 2011 23:00:00 +0100 5197041 http://www.medworm.com/index.php?rid=5197042&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21880548%26dopt%3DAbstract Authors: Patra S, Elisevich K, Spanaki-Varelas M, Gaddam S, Smith BJ Abstract Ictal nonspeech vocalizations have been described as manifestations of either frontal or temporal epileptogenicity originating mainly from the dominant hemisphere. Ictal barking, particularly, has been considered a manifestation of mesial frontal epilepsy. A 42-year-old right-handed male with posttraumatic drug-resistant complex partial epilepsy manifested ictal barking near electrographic onset. Extraoperative electrocorticography with subdural electrode coverage of the right frontoparietal and temporal and left frontal surfaces provided surveillance of ictal origin and propagation. Ictal origin was identified in the right mesial temporal lobe with barking vocalization manifesting within 3s of electrogra... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5197042 Sun, 28 Aug 2011 23:00:00 +0100 5197042 http://www.medworm.com/index.php?rid=5180615&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21872534%26dopt%3DAbstract Authors: Helmers SL, Duh MS, Guérin A, Sarda SP, Samuelson TM, Bunker MT, Olin BD, Jackson SD, Faught E Abstract We evaluated long-term medical and economic benefits of vagus nerve stimulation (VNS) therapy in drug-resistant epilepsy. A pre-post analysis was conducted using multistate Medicaid data (January 1997-June 2009). One thousand six hundred fifty-five patients with one or more neurologist visits with epilepsy diagnoses (ICD-9 345.xx, 780.3, or 780.39), one or more procedures for vagus nerve stimulator implantation, one or more antiepileptic drugs (AEDs), and 6 or more months of continuous Medicaid enrollment pre- and post-VNS were selected. The pre-VNS period was 6months. The post-VNS period extended from implantation to device removal, death, Medicaid disenrollment, or st... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5180615 Fri, 26 Aug 2011 23:00:00 +0100 5180615 http://www.medworm.com/index.php?rid=5180616&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21872533%26dopt%3DAbstract Authors: Urbain C, Di Vincenzo T, Peigneux P, Van Bogaert P Abstract We investigated sleep-related declarative memory consolidation in four children with focal idiopathic epilepsy. In a population of healthy control children, recall of learned pairs of words was increased after a night of sleep, but not after a daytime wakefulness period. In children with epilepsy (1 case of benign epilepsy with centro-temporal spikes, 1 case of benign childhood epilepsy with occipital paroxysms, and 2 cases of epileptic encephalopathy (EE) with continuous spike and waves during slow-wave sleep, CSWS), recall performance significantly decreased overnight, suggesting impairment in sleep-related declarative memory consolidation. Hydrocortisone treatment in one patient with EE with CSWS resulted in no... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5180616 Thu, 25 Aug 2011 23:00:00 +0100 5180616 http://www.medworm.com/index.php?rid=5180614&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21873119%26dopt%3DAbstract This study demonstrates that the consequences of ELS extend to the PFC, which may help explain the high prevalence of comorbid behavioral disorders following ELS. PMID: 21873119 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5180614 Thu, 25 Aug 2011 23:00:00 +0100 5180614 http://www.medworm.com/index.php?rid=5180613&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21873120%26dopt%3DAbstract This study was aimed at examining spatial learning and memory in nonoperated temporal lobe epilepsy (TLE). Twenty-five patients with a refractory epileptic focus located in the temporal lobe (10 in the right hemisphere and 15 in the left hemisphere) and 25 healthy age-matched controls performed the "Boxes Room," a virtual reality version of the holeboard. They were trained in 10 trials to locate the reward boxes in a room with 16 of them available. Participants also completed a comprehensive neuropsychological evaluation. Patients performed significantly worse relative to the control group. They traveled longer distances and committed more errors than controls. No differences in performance were found within the TLE group when gender or lateralization of the epileptic focus was considered ... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5180613 Thu, 25 Aug 2011 23:00:00 +0100 5180613 http://www.medworm.com/index.php?rid=5180618&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21871838%26dopt%3DAbstract CONCLUSION: Quality of life of adult patients with epilepsy decreases with older age, more difficult course of disease, and higher seizure frequency. Higher educational level and economic status are protective factors in the QOL of adult patients. PMID: 21871838 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5180618 Tue, 23 Aug 2011 23:00:00 +0100 5180618 http://www.medworm.com/index.php?rid=5180617&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21871839%26dopt%3DAbstract Discussions in academic circles have moved from criticism of negative portrayals of mental illness in earlier films to their use in teaching sessions. Films can be used either in full length or clip format to conduct training modules. Use of the film Stigmata to train residents about diagnostic dilemmas and taking a diagnostic approach to patients is discussed. PMID: 21871839 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5180617 Tue, 23 Aug 2011 23:00:00 +0100 5180617 http://www.medworm.com/index.php?rid=5162870&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21862414%26dopt%3DAbstract Authors: Sarco DP, Boyer K, Lundy-Krigbaum SM, Takeoka M, Jensen F, Gregas M, Waber DP Abstract Children with benign rolandic epilepsy (BRE) experience elevated rates of cognitive, behavioral, and affective problems. Frequent epileptiform spike discharges may impair behavioral functioning. To elucidate this relationship, we evaluated associations between the EEG spike frequency index (SI) and parental ratings of psychosocial adjustment and executive functioning in school-aged children with EEGs typical of BRE. Twenty-one children (6-12years) participated. Parents completed validated questionnaires at a median of 5months (range: 1-8) after a routine outpatient EEG. The EEG SI was calculated for wakefulness and sleep. The strength of association between the SI and behavioral variable... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5162870 Fri, 19 Aug 2011 23:00:00 +0100 5162870 http://www.medworm.com/index.php?rid=5162930&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21855418%26dopt%3DAbstract Authors: Okazaki M, Adachi N, Ito M, Watanabe M, Watanabe Y, Kato M, Onuma T Abstract To investigate the clinical effects of antidepressants on seizure frequency of patients with epilepsy treated with antiepileptic drugs, we retrospectively evaluated the 1-year course of seizure frequency. One hundred twenty-one patients with epilepsy treated with antidepressants and 300 patients with epilepsy not treated with antidepressants (controls) were the subjects of this study. Seizure frequency over the 1-year period of administration of antidepressants was retrospectively evaluated and compared with that for controls. In the patients with epilepsy taking antidepressants, seizure frequencies at four observation points (1, 3, 6, and 12months after starting antidepressants) were equivalent t... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5162930 Wed, 17 Aug 2011 23:00:00 +0100 5162930 http://www.medworm.com/index.php?rid=5162906&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21855419%26dopt%3DAbstract Authors: Johnson-Markve BL, Lee GP, Loring DW, Viner KM Abstract Frontal lobe memory disorders are distinguished from hippocampal memory disorders by poor organization of encoding and retrieval, among other things. Because the verbal Selective Reminding Test (SRT) has a metamemory ("remembering-to-remember") component, it may be useful in distinguishing frontal from temporal lobe memory disorders in patients with intractable epilepsy. Thirty-four patients with frontal lobe epilepsy (FLE) and 34 with temporal lobe epilepsy (TLE) underwent a comprehensive neuropsychological evaluation that included multiple memory and executive function tests. Patients with FLE performed significantly worse than those with TLE on SRT measures and Wechsler Memory Scale, Third Edition, Logical Memory (... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5162906 Wed, 17 Aug 2011 23:00:00 +0100 5162906 http://www.medworm.com/index.php?rid=5162873&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21856237%26dopt%3DAbstract Authors: Mostacci B, Bisulli F, Alvisi L, Licchetta L, Baruzzi A, Tinuper P Abstract Psychogenic nonepileptic seizures (PNES) are highly prevalent in selected populations, with a strong impact in terms of morbidity and social cost. The gold standard for PNES diagnosis is video/EEG recording of a typical attack. However this technique is costly and not always available. In addition, many patients are treated with antiepileptic drugs for several years before undergoing video/EEG recording. The diagnosis is further complicated by concomitant epileptic seizures in some patients with PNES. Therefore, a good knowledge of PNES semiology is important for early screening of patients for video/EEG recording and for correct interpretation of the examination. We reviewed the literature on vide... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5162873 Tue, 16 Aug 2011 23:00:00 +0100 5162873 http://www.medworm.com/index.php?rid=5162871&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21856238%26dopt%3DAbstract Authors: Ibrahim GM, Fallah A, Snead OC, Elliott I, Drake JM, Bernstein M, Rutka JT Abstract The widespread inclusion of surgical strategies in the treatment of medically intractable epilepsy is largely justified by the medical and psychosocial burden of the illness. Performing these procedures in pediatric populations is associated with distinct challenges ranging from unique seizure etiologies to issues surrounding brain development and functional plasticity. As the trend toward more aggressive surgical intervention continues, the ethical foundation of current and emerging practices must be increasingly scrutinized. Here, we present the first article discussing ethical issues in the surgical management of medically intractable epilepsies in children. We discuss principles of info... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5162871 Tue, 16 Aug 2011 23:00:00 +0100 5162871 http://www.medworm.com/index.php?rid=5144749&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21852198%26dopt%3DAbstract Authors: Roberts JI, Metcalfe A, Abdulla F, Wiebe S, Hanson A, Federico P, Jetté N Abstract We aimed to assess physician knowledge for 2009 guidelines established by the American Academy of Neurology and American Epilepsy Society regarding issues related to pregnancy for women with epilepsy. A questionnaire was developed and distributed to all neurologists and neurology residents practicing in a large Canadian health region serving a population of 1.4 million. Descriptive statistics were obtained and percentage of correct responses was calculated. Forty-five physicians completed the survey (response rate = 83.3%), with a median correct score of 50%. Residents were more likely (93.3%) to state that this information was important to their practice than staff physicians (40.0%). Over... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5144749 Mon, 15 Aug 2011 23:00:00 +0100 5144749 http://www.medworm.com/index.php?rid=5144748&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21852199%26dopt%3DAbstract Brain damage and IQ in unilateral Sturge-Weber syndrome: Support for a "fresh start" hypothesis. Epilepsy Behav. 2011 Aug 16; Authors: Behen ME, Juhász C, Wolfe-Christensen C, Guy W, Halverson S, Rothermel R, Janisse J, Chugani HT Abstract We tested the hypothesis that extent of severe hypometabolism measured by fluorodeoxyglucose PET has a U-shaped (nonlinear) relationship to IQ in children with unilateral Sturge-Weber syndrome. Thirty-five consecutive children (age range: 30-153months) with Sturge-Weber syndrome and unilateral brain involvement were enrolled in the study. Participants underwent cognitive assessment and interictal fluorodeoxyglucose PET scans. Regression analyses tested whether a quadratic model best accounted for the relationship between extent of severe... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5144748 Mon, 15 Aug 2011 23:00:00 +0100 5144748 http://www.medworm.com/index.php?rid=5144747&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21852200%26dopt%3DAbstract This study showed that pretreatment with R-Pia and SCH58261 reduces seizure occurrence, although only R-Pia has neuroprotective properties. Further studies are needed to clarify the neuroprotective role of A(2A) in TLE. PMID: 21852200 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5144747 Mon, 15 Aug 2011 23:00:00 +0100 5144747 http://www.medworm.com/index.php?rid=5144752&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21849259%26dopt%3DAbstract In this study, the effects of aqueous extracts of Carum copticum seeds (CCS) were evaluated in kindling models of epilepsy. Additionally, the sedative and anxiolytic effects of the extract were assessed. For pentylenetetrazole (PTZ) kindling, rats received a subconvulsant dose of PTZ (40mg/kg, ip) every second day and seizure stages were recorded. CCS aqueous extract (200, 400, or 600mg/kg, ip) was injected 30 minutes prior to each PTZ injection. In electrical kindling, bipolar stimulating and monopolar recording electrodes were implanted stereotaxically in the right basolateral amygdala of male Sprague-Dawley rats. After kindling, the effect of aqueous extracts of CCS (200, 400, or 600mg/kg, ip) on afterdischarge duration, duration of rearing, forelimb clonus, and loss of equilibrium (sta... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5144752 Sun, 14 Aug 2011 23:00:00 +0100 5144752 http://www.medworm.com/index.php?rid=5144751&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21849260%26dopt%3DAbstract Authors: Meador KJ, Brashear HR, Wiegand F, Zannikos P, Novak G Abstract Adverse cognitive effects are an important concern for drugs that influence the central nervous system. Carisbamate is a novel drug in development for treatment of seizures and neuropathic pain. Information on its cognitive effects is limited. Three controlled, multiple-dose, crossover studies with treatment durations of 5-9days were designed to examine the cognitive effects of carisbamate on healthy volunteers. In one study, apparent dose-dependent effects on response, vigilance, and recognition speed were observed (1000mg and 1500mg/day). Carisbamate did not differ from placebo for most variables in the other two studies, but increased reaction time and reduced Sternberg memory were seen at higher dosages. C... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5144751 Sun, 14 Aug 2011 23:00:00 +0100 5144751 http://www.medworm.com/index.php?rid=5144750&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21849261%26dopt%3DAbstract We examined utilization of special education services (SpES) in relation to neurocognitive test scores in a case-matched sibling control study. In a follow-up assessment 8-9years after entry into a prospective study of childhood-onset epilepsy, cases and siblings participated in an interview and standardized neurocognitive testing. Analyses included 142 pairs in which both had Full Scale IQ ≥80 and the case had normal examination and imaging. Sixty-four (45%) cases and 25 (17.6%) controls reported SpES utilization, (matched odds ratio [mOR]=5.3, P<0.0001). Adjustment for neurocognitive test scores resulted in a mOR of 4.6 (P<0.0001). Types and duration of services were similar in cases and controls. Twenty-four percent of school-aged cases were already receiving services at the tim... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5144750 Sun, 14 Aug 2011 23:00:00 +0100 5144750 http://www.medworm.com/index.php?rid=5144757&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21840765%26dopt%3DAbstract Authors: Drislane FW, Lopez MR, Blum AS, Schomer DL Abstract Several studies have shown reliable predictive factors for outcome in status epilepticus (SE), especially etiology and presentation in coma. Duration of SE is predictive, but probably only in the first few hours, and there have been many reports of patients treated successfully for SE lasting many days or weeks. Nevertheless, there are many other patients with SE treated for prolonged periods without success, sometimes apparently futilely. We compared clinical features of 10 survivors of prolonged SE with those of a matched cohort treated for similarly prolonged episodes but unsuccessfully, looking for exceptions to known predictive factors. Multiple medical problems (i.e., etiologies) and coma on presentation were confir... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5144757 Fri, 12 Aug 2011 23:00:00 +0100 5144757 http://www.medworm.com/index.php?rid=5144756&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21840766%26dopt%3DAbstract Authors: Brigo F PMID: 21840766 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5144756 Thu, 11 Aug 2011 23:00:00 +0100 5144756 http://www.medworm.com/index.php?rid=5144755&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21840767%26dopt%3DAbstract This study was performed to analyze sociocultural beliefs about epilepsy among Guaraní communities in Bolivia. People with epilepsy, their family members, the general population, and local health care personnel were interviewed about the meaning of and beliefs, feelings, and practices concerning epilepsy. Epilepsy is called mano-mano, a term that means being in a constant passage between life and death. The disease is attributed mainly to a failure to observe a fasting period and to other eating habits. Natural remedies are the most recommended treatments even though half of respondents reported that antiepileptic drugs may be effective. The concept of epilepsy as an embodied disease with natural causes appears to differ from that documented in other traditional societies. People with epi... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5144755 Thu, 11 Aug 2011 23:00:00 +0100 5144755 http://www.medworm.com/index.php?rid=5144754&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21840768%26dopt%3DAbstract In conclusion, melatonin and agmatine exhibit an additive effect in decreasing pentylenetetrazole-induced seizure threshold in mice, probably through ML(1/2) receptors. PMID: 21840768 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5144754 Thu, 11 Aug 2011 23:00:00 +0100 5144754 http://www.medworm.com/index.php?rid=5144753&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21840769%26dopt%3DAbstract Authors: Magaudda A, Gugliotta SC, Tallarico R, Buccheri T, Alfa R, Laganà A Abstract Psychogenic nonepileptic seizures (PNES) can be observed in patients with or without epilepsy (mixed and pure PNES). Patients with mixed PNES are usually considered to be a homogeneous group characterized by the coexistent epilepsy. Our study found that patients with mixed PNES were not homogeneous, but could be divided into three groups based on epilepsy type, mental level, comorbid psychiatric disorders, and history of traumatic experiences. Group 1 patients have pharmacoresistant epilepsy, normal cognition, and comorbid anxiety and/or depressive disorders. Here, PNES etiology is the epilepsy-related problems. In group 2 patients, the epilepsy is associated with mental retardation and dependent... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5144753 Thu, 11 Aug 2011 23:00:00 +0100 5144753 http://www.medworm.com/index.php?rid=5144758&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21831717%26dopt%3DAbstract Authors: Esopenko C, Crossley M, Haugrud N, Borowsky R Abstract Previous neuroimaging research has shown left hemisphere dominance during the semantic processing of embodied action-related stimuli. The goal of our research was to examine how action-related stimuli are processed in individuals after right or left hemispherectomy. S.M. (right hemispherectomy), J.H. (left hemispherectomy), and healthy control participants completed naming and semantic generation tasks with picture and word stimuli with referents that are used by arms or legs. Our results showed evidence of a dissociation for pictures of objects used by legs. Specifically, the naming task showed that, relative to controls, S.M. is impaired on accuracy, whereas J.H. performs closer to normal levels. For the semantic gen... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5144758 Sun, 07 Aug 2011 23:00:00 +0100 5144758 http://www.medworm.com/index.php?rid=5119275&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21824821%26dopt%3DAbstract Authors: Herman ST, Takeoka M, Hughes JR, Drislane FW Electroencephalography (EEG) remains central to the investigation of epilepsy. This review discusses two clinical problems at the temporal extremes of neurophysiologic recording: evaluation of the clinical significance of individual spike discharges in benign epilepsy of childhood with centrotemporal spikes (BECTS), and prolonged (several days) continuous EEG monitoring in the ICU. BECTS is misdiagnosed often, and probably mis-treated often as well. Though the long-term outcome is usually excellent, it remains unclear whether the individual epileptiform discharges have a clinical effect. Answering this question is difficult, in part because of the natural evolution of the epilepsy and its different appearance depending on wakefulnes... Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5119275 Fri, 05 Aug 2011 23:00:00 +0100 5119275 http://www.medworm.com/index.php?rid=5119286&cid=s_35536_25_f&fid=35536&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21820359%26dopt%3DAbstract We describe the emergence of a new type of disabling, recurrent partial seizure immediately after initiation of vagus nerve stimulation in a 51-year-old man with a known history of refractory partial epilepsy. Discontinuation of vagus nerve stimulation therapy and multiple antiepileptic drug interventions were required to abort these unexpected new seizures. We conclude that vagus nerve stimulation may induce paradoxical seizures, similarly to some antiepileptic drugs. PMID: 21820359 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour) Epilepsy and Behaviour journals http://www.medworm.com/rss/comments.php?id=5119286 Wed, 03 Aug 2011 23:00:00 +0100 5119286