European Heart Journal via MedWorm.com MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'European Heart Journal' source. Wed, 08 Feb 2012 09:32:38 +0100 Cardiac calciphylaxis presenting as endocarditis http://www.medworm.com/index.php?rid=5647447&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F3%2F416%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5647447 Wed, 01 Feb 2012 05:00:00 +0100 5647447 The vascular aneurysms of Ehlers-Danlos syndrome type IV http://www.medworm.com/index.php?rid=5647446&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F3%2F415%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5647446 Wed, 01 Feb 2012 05:00:00 +0100 5647446 Cellular adaptive response to chronic radiation exposure in interventional cardiologists http://www.medworm.com/index.php?rid=5647445&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F3%2F408%3Frss%3D1 Conclusion In interventional cardiologists, chronic exposure to low-dose radiation is associated with an altered redox balance mirrored by an increase in hydrogen peroxide and with two possibly adaptive cellular responses: (i) an enhanced antioxidant defence (increase in GSH, counteracting increased oxyradical stress) and (ii) an increased susceptibility to apoptotic induction which might efficiently remove genetically damaged cells. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5647445 Wed, 01 Feb 2012 05:00:00 +0100 5647445 Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration http://www.medworm.com/index.php?rid=5647444&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F3%2F393%3Frss%3D1 Conclusion Several SNPs predicting CHD events appear to involve pathways not currently indexed by the established or emerging risk factors; others involved changes in blood lipids including triglycerides or HDL-cholesterol as well as LDL-cholesterol. The overlapping association of SNPs with multiple risk factors and biomarkers supports the existence of shared points of regulation for these phenotypes. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5647444 Wed, 01 Feb 2012 05:00:00 +0100 5647444 The prognostic meaning of the full spectrum of aVR ST-segment changes in acute myocardial infarction http://www.medworm.com/index.php?rid=5647443&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F3%2F384%3Frss%3D1 Conclusion There is a U-shaped relationship between 30-day mortality and aVR ST level in patients presenting with anterior but not inferior ST elevation MI. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5647443 Wed, 01 Feb 2012 05:00:00 +0100 5647443 In vivo characterization of coronary plaques: novel findings from comparing greyscale and virtual histology intravascular ultrasound and near-infrared spectroscopy http://www.medworm.com/index.php?rid=5647442&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F3%2F372%3Frss%3D1 Conclusion Combining NIRS with IVUS contributes to the understanding of plaque characterization in vivo. Further studies are warranted to determine whether combining NIRS and IVUS will contribute to the assessment of high-risk plaques to predict outcomes in patients with coronary artery disease. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5647442 Wed, 01 Feb 2012 05:00:00 +0100 5647442 Endothelial function assessment: flow-mediated dilation and constriction provide different and complementary information on the presence of coronary artery disease http://www.medworm.com/index.php?rid=5647441&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F3%2F363%3Frss%3D1 Conclusion Endothelial function assessment provides modest but statistically significant additional information in predicting the presence of CAD. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5647441 Wed, 01 Feb 2012 05:00:00 +0100 5647441 Association of cerebral blood flow with the development of cardiac death or urgent heart transplantation in patients with systolic heart failure http://www.medworm.com/index.php?rid=5647440&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F3%2F354%3Frss%3D1 Conclusion Cerebral blood flow was associated with the development of long-term outcomes in systolic HF, and therefore may be useful in identifying patients suitable for heart transplantation. This finding is especially relevant for patients in whom exercise tests may not be performed sufficiently. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5647440 Wed, 01 Feb 2012 05:00:00 +0100 5647440 Mitochondrial haplogroups associated with end-stage heart failure and coronary allograft vasculopathy in heart transplant patients http://www.medworm.com/index.php?rid=5647439&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F3%2F346%3Frss%3D1 Conclusions Mitochondrial haplogroups behave like risk factors for the progress to end-stage HF in a Spanish cardiac transplant population. Mitochondrial DNA variants may have some influence on the appearance of cardiac transplant complications. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5647439 Wed, 01 Feb 2012 05:00:00 +0100 5647439 Cardiovascular biomarkers and vascular function during childhood in the offspring of mothers with hypertensive disorders of pregnancy: findings from the Avon Longitudinal Study of Parents and Children http://www.medworm.com/index.php?rid=5647438&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F3%2F335%3Frss%3D1 Conclusion Pre-eclampsia and gestational hypertension are associated with higher offspring BP in childhood in the absence of other vascular alterations or metabolic derangements. The findings support the existence of shared mother-offspring risk factors that are specific for higher BP, rather than the additional cardiometabolic abnormalities of hypertensive disorder of pregnancy having long-term consequences for offspring. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5647438 Wed, 01 Feb 2012 05:00:00 +0100 5647438 Genetic variants, plasma lipoprotein(a) levels, and risk of cardiovascular morbidity and mortality among two prospective cohorts of type 2 diabetes http://www.medworm.com/index.php?rid=5647437&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F3%2F325%3Frss%3D1 Conclusion Our data indicate that the effect of Lp(a) on CVD risk among diabetic patients might be different from that in the general population. Diabetes status may attenuate the relation between Lp(a) and cardiovascular risk. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5647437 Wed, 01 Feb 2012 05:00:00 +0100 5647437 Pharmacist intervention in primary care to improve outcomes in patients with left ventricular systolic dysfunction http://www.medworm.com/index.php?rid=5647436&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F3%2F314%3Frss%3D1 Conclusion A low-intensity, pharmacist-led collaborative intervention in primary care resulted in modest improvements in prescribing of disease-modifying medications but did not improve clinical outcomes in a population that was relatively well treated at baseline. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5647436 Wed, 01 Feb 2012 05:00:00 +0100 5647436 Biventricular pacing: current trends and future strategies http://www.medworm.com/index.php?rid=5647435&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F3%2F305%3Frss%3D1 The role of biventricular pacing is expanding beyond the New York Heart Association classes III and IV heart failure (HF) patient to include less symptomatic patients, earlier in the course of their disease process. This multisite pacing strategy has substantially altered the natural course of ventricular failure, exerting its physiological impact through favourable cardiac remodelling and improving the ejection fraction. This has in turn resulted in long-term clinical benefits such as improved quality of life and functional capacity with a concomitant reduction in hospitalization for HF and overall mortality. Despite the successes of cardiac resynchronization therapy (CRT) and the recent expansion of its role in the treatment of HF patients, there remain some inherent limitations to the t... European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5647435 Wed, 01 Feb 2012 05:00:00 +0100 5647435 Genetics of inherited cardiomyopathy http://www.medworm.com/index.php?rid=5647434&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F3%2F296%3Frss%3D1 During the past two decades, numerous disease-causing genes for different cardiomyopathies have been identified. These discoveries have led to better understanding of disease pathogenesis and initial steps in the application of mutation analysis in the evaluation of affected individuals and their family members. As knowledge of the genetic abnormalities, and insight into cellular and organ biology has grown, so has appreciation of the level of complexity of interaction between genotype and phenotype across disease states. What were initially thought to be one-to-one gene-disease correlates have turned out to display important relational plasticity dependent in large part on the genetic and environmental backgrounds into which the genes of interest express. The current state of knowledge wi... European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5647434 Wed, 01 Feb 2012 05:00:00 +0100 5647434 Biological effects of low-dose radiation: of harm and hormesis http://www.medworm.com/index.php?rid=5647433&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F3%2F292%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5647433 Wed, 01 Feb 2012 05:00:00 +0100 5647433 Will the interplay between genetic markers for risk factors for a disease and the disease itself bring genetics closer to clinical practice? Great expectations http://www.medworm.com/index.php?rid=5647432&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F3%2F290%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5647432 Wed, 01 Feb 2012 05:00:00 +0100 5647432 CardioPulse Articles * A new ESC journal for all cardiac imaging modalities * Archives of the Turkish Society of Cardiology * Azerbaijan joins the European Society of Cardiology family * Current Problems in Cardiology has been providing in-depth coverage of clinical issues for decades * Heart disease and cancer: The International Cardioncology Society * People's corner: promotion * Professor Uta C. Hoppe, MD, FESC * The story of the heartbeat, continued http://www.medworm.com/index.php?rid=5647431&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F3%2F281%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5647431 Wed, 01 Feb 2012 05:00:00 +0100 5647431 Obituary: John T. Shepherd, MD, MChir., DSc. http://www.medworm.com/index.php?rid=5597123&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F2%2F279%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5597123 Sat, 14 Jan 2012 05:00:00 +0100 5597123 List of Reviewers 2011 http://www.medworm.com/index.php?rid=5597122&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F2%2F274%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5597122 Sat, 14 Jan 2012 05:00:00 +0100 5597122 Synergistic effect of liver X receptor activation and simvastatin on plaque regression and stabilization: an magnetic resonance imaging study in a model of advanced atherosclerosis http://www.medworm.com/index.php?rid=5597121&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F2%2F264%3Frss%3D1 Conclusion The results of the present study show that LXR-623 significantly reduces the progression of atherosclerosis and induces plaque regression in combination with simvastatin. These observations could drive future development of novel anti-atherosclerotic therapeutic approaches. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5597121 Sat, 14 Jan 2012 05:00:00 +0100 5597121 In vitro and in vivo evidence for the role of elastase shedding of CD163 in human atherothrombosis http://www.medworm.com/index.php?rid=5597120&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F2%2F252%3Frss%3D1 Conclusion Our results suggest that neutrophil elastase promotes CD163 shedding, resulting in a decreased clearance of Hb by macrophages, which may favour plaque destabilization. This may be reflected by increased plasma levels of sCD163 and elastase/α1-AT complexes which are positively correlated in patients with coronary artery disease. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5597120 Sat, 14 Jan 2012 05:00:00 +0100 5597120 Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies http://www.medworm.com/index.php?rid=5597119&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F2%2F238%3Frss%3D1 Conclusion Levels of Lp-PLA2 mass and activity were associated with PLA2G7, the gene coding for this protein. Lipoprotein-associated phospholipase A2 activity was also strongly associated with genetic variants related to low-density lipoprotein cholesterol levels. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5597119 Sat, 14 Jan 2012 05:00:00 +0100 5597119 Progression of human carotid and femoral atherosclerosis: a prospective follow-up study by magnetic resonance vessel wall imaging http://www.medworm.com/index.php?rid=5597118&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F2%2F230%3Frss%3D1 Conclusion The atherosclerotic burden increased significantly in both carotid and femoral arteries. However, carotid plaque progression was associated with negative remodelling, whereas the increase in femoral plaque burden was compensated by positive remodelling. This finding could be related to anatomic and flow differences and/or to the distinct degree of obstruction in the two arterial territories. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5597118 Sat, 14 Jan 2012 05:00:00 +0100 5597118 Intracardiac blood cyst: rare finding in a complex congenital heart lesion http://www.medworm.com/index.php?rid=5597117&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F2%2F229%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5597117 Sat, 14 Jan 2012 05:00:00 +0100 5597117 Determinants of magnetic resonance imaging detected carotid plaque components: the Rotterdam Study http://www.medworm.com/index.php?rid=5597116&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F2%2F221%3Frss%3D1 Conclusion In subjects from the general population with carotid wall thickening, intraplaque haemorrhage and lipid core—both considered indicators of unstable plaque—are highly frequent and more prevalent in men compared with women. Furthermore, different risk factors are associated with these plaque components: hypertension and current smoking were risk factors for the presence of intraplaque haemorrhage, and hypercholesterolaemia was the only risk factor for lipid core presence. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5597116 Sat, 14 Jan 2012 05:00:00 +0100 5597116 Prevalence of cardiovascular disease risk factor in the Chinese population: the 2007-2008 China National Diabetes and Metabolic Disorders Study http://www.medworm.com/index.php?rid=5597115&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F2%2F213%3Frss%3D1 Conclusion Morbidity attributed to the five defined cardiovascular risk factors was high in the Chinese population, with multiple risk factors present in the same individual. Therefore, reasonable prevention strategies should be designed to attenuate the rapid rise in cardiovascular morbidity. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5597115 Sat, 14 Jan 2012 05:00:00 +0100 5597115 Serum aldosterone and its relationship to left ventricular structure and geometry in patients with preserved left ventricular ejection fraction http://www.medworm.com/index.php?rid=5597114&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F2%2F203%3Frss%3D1 Conclusion Circulating aldosterone but not ARR levels are independently related to echocardiographic parameters of LV structure, particularly in women. Higher SAC however was related to concentric LVH in either sex. Our findings in a large CV risk cohort with preserved LVEF indicate aldosterone-mediated pro-hypertrophic effects as a potential pathway for structural alterations of the left ventricular myocardium. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5597114 Sat, 14 Jan 2012 05:00:00 +0100 5597114 Aldosterone, mortality, and acute ischaemic events in coronary artery disease patients outside the setting of acute myocardial infarction or heart failure http://www.medworm.com/index.php?rid=5597113&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F2%2F191%3Frss%3D1 Conclusion Our results demonstrate that, in patients with CAD but without heart failure or acute MI, the level of aldosterone is strongly and independently associated with mortality and the occurrence of acute ischaemic events. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5597113 Sat, 14 Jan 2012 05:00:00 +0100 5597113 Interventricular septum rupture after transcatheter aortic valve implantation http://www.medworm.com/index.php?rid=5597112&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F2%2F190%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5597112 Sat, 14 Jan 2012 05:00:00 +0100 5597112 Common carotid artery intima-media thickness is as good as carotid intima-media thickness of all carotid artery segments in improving prediction of coronary heart disease risk in the Atherosclerosis Risk in Communities (ARIC) study http://www.medworm.com/index.php?rid=5597111&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F2%2F183%3Frss%3D1 Conclusion Coronary heart disease risk prediction can be improved by adding A-CIMT + plaque or CCA-IMT + plaque information to TRF. Therefore, evaluating the carotid artery for plaque presence and measuring CCA-IMT, which is easier and more reliable than measuring A-CIMT, provide a good alternative to measuring A-CIMT for CHD risk prediction. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5597111 Sat, 14 Jan 2012 05:00:00 +0100 5597111 The win ratio: a new approach to the analysis of composite endpoints in clinical trials based on clinical priorities http://www.medworm.com/index.php?rid=5597110&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F2%2F176%3Frss%3D1 The conventional reporting of composite endpoints in clinical trials has an inherent limitation in that it emphasizes each patient's first event, which is often the outcome of lesser clinical importance. To overcome this problem, we introduce the concept of the win ratio for reporting composite endpoints. Patients in the new treatment and control groups are formed into matched pairs based on their risk profiles. Consider a primary composite endpoint, e.g. cardiovascular (CV) death and heart failure hospitalization (HF hosp) in heart failure trials. For each matched pair, the new treatment patient is labelled a ‘winner’ or a ‘loser’ depending on who had a CV death first. If that is not known, only then they are labelled a ‘winner’ or ‘loser’ d... European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5597110 Sat, 14 Jan 2012 05:00:00 +0100 5597110 A systematic review on pharmacogenetics in cardiovascular disease: is it ready for clinical application? http://www.medworm.com/index.php?rid=5597109&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F2%2F165%3Frss%3D1 Pharmacogenetics is the search for heritable genetic polymorphisms that influence responses to drug therapy. The most important application of pharmacogenetics is to guide choosing agents with the greatest potential of efficacy and smallest risk of adverse drug reactions. Many studies focusing on drug–gene interactions have been published in recent years, some of which led to adaptation of FDA recommendations, indicating that we are on the verge of the clinical application of genetic information in drug therapy. This systematic review provides a comprehensive overview of the current knowledge on pharmacogenetics of all major drug classes currently used in the treatment of cardiovascular diseases. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5597109 Sat, 14 Jan 2012 05:00:00 +0100 5597109 Plasma aldosterone levels in patients with coronary artery disease without heart failure or myocardial infarction: implications for pathophsiology, prognosis, and therapy http://www.medworm.com/index.php?rid=5597108&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F2%2F162%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5597108 Sat, 14 Jan 2012 05:00:00 +0100 5597108 The time has come for clinical cardiovascular trials with plaque characterization as an endpoint http://www.medworm.com/index.php?rid=5597107&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F2%2F160%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5597107 Sat, 14 Jan 2012 05:00:00 +0100 5597107 Public health crisis in China is about to accelerate the public health crisis in our world's population http://www.medworm.com/index.php?rid=5597106&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F2%2F157%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5597106 Sat, 14 Jan 2012 05:00:00 +0100 5597106 CardioPulse Articles * Bleeding risk assessment and management in atrial fibrillation patients * Current Opinion in Cardiology is aimed at the practicing cardiologist * Dr Harvey Weiss discoverer of the anti-platelet benefits of acetylsalicylic acid * Heart disease and cancer: the new discipline of cardioncology * The story of the heartbeat, II * Book review * Transesophageal Echocardiography * Asia's heart for diversity http://www.medworm.com/index.php?rid=5597105&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F2%2F147%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5597105 Sat, 14 Jan 2012 05:00:00 +0100 5597105 Late-breaking clinical trials from the American Heart Association Scientific Sessions 2011 in Orlando, FL, USA, 13-16 November http://www.medworm.com/index.php?rid=5559742&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F1%2F139%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5559742 Sun, 01 Jan 2012 05:00:00 +0100 5559742 Aorto-right atrial shunt due to perforated sinus of valsalva aneurysm in a young athlete: a rare congenital defect confirmed by various non-invasive imaging modalities http://www.medworm.com/index.php?rid=5559741&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F1%2F138%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5559741 Sun, 01 Jan 2012 05:00:00 +0100 5559741 Granulocyte colony-stimulating factor treatment plus dipeptidylpeptidase-IV inhibition augments myocardial regeneration in mice expressing cyclin D2 in adult cardiomyocytes http://www.medworm.com/index.php?rid=5559740&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F1%2F129%3Frss%3D1 Conclusion These data strongly suggest that G-CSF plus DPP-IV inhibition, combined with cardiomyocyte cell cycle activation, leads to enhanced myocardial regeneration following MI. The data are also consistent with the notion that altering adverse post-injury remodelling renders the myocardium more permissive for cardiomyocyte repopulation. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5559740 Sun, 01 Jan 2012 05:00:00 +0100 5559740 Capture of circulatory endothelial progenitor cells and accelerated re-endothelialization of a bio-engineered stent in human ex vivo shunt and rabbit denudation model http://www.medworm.com/index.php?rid=5559739&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F1%2F120%3Frss%3D1 Conclusion In this proof-of-concept study, we have demonstrated that the bio-engineered EPC-capture stent, Genous™ R™ stent, is effective in EPC capture, resulting in accelerated re-endothelialization and reduced thrombogenicity. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5559739 Sun, 01 Jan 2012 05:00:00 +0100 5559739 Carotid artery intima-media thickness and plaque score can predict the SYNTAX score http://www.medworm.com/index.php?rid=5559738&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F1%2F113%3Frss%3D1 Conclusion Carotid-US parameters have predictive value for the SXscore. In addition, the PS and the meanIMT showed excellent negative predictive value for the presence of complex coronary artery lesions. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5559738 Sun, 01 Jan 2012 05:00:00 +0100 5559738 Transcatheter implantation of an aortic valve prosthesis in a female patient with severe bicuspid aortic stenosis http://www.medworm.com/index.php?rid=5559737&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F1%2F112%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5559737 Sun, 01 Jan 2012 05:00:00 +0100 5559737 Ischaemic postconditioning revisited: lack of effects on infarct size following primary percutaneous coronary intervention http://www.medworm.com/index.php?rid=5559736&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F1%2F103%3Frss%3D1 Conclusion This randomized study suggests that p-cond during primary PCI does not reduce infarct size or improve myocardial function recovery at both short- and long-term follow-up and might have a potential harmful effect. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5559736 Sun, 01 Jan 2012 05:00:00 +0100 5559736 Relationship between discharge heart rate and mortality in patients after acute myocardial infarction treated with primary percutaneous coronary intervention http://www.medworm.com/index.php?rid=5559735&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F1%2F96%3Frss%3D1 Conclusion In STEMI patients treated with primary PCI and optimal medical therapy, heart rate at discharge was an important predictor of mortality up to 4 years follow-up even after adjustment for parameters reflecting a greater infarct size and the presence of heart failure. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5559735 Sun, 01 Jan 2012 05:00:00 +0100 5559735 Primary angioplasty in acute myocardial infarction with right bundle branch block: should new onset right bundle branch block be added to future guidelines as an indication for reperfusion therapy? http://www.medworm.com/index.php?rid=5559734&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F1%2F86%3Frss%3D1 Conclusion Acute myocardial infarction with RBBB is frequently caused by the complete occlusion of the infarct-related artery and is more frequently treated with primary PCI when compared with AMI + LBBB. In-hospital mortality of patients with AMI and RBBB is highest from all ECG presentations of AMI. Restoration of coronary flow by primary PCI may lead to resolution of the conduction delay on the discharge ECG. Right bundle branch block should strongly be considered for listing in future guidelines as a standard indication for reperfusion therapy, in the same way as LBBB. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5559734 Sun, 01 Jan 2012 05:00:00 +0100 5559734 Thin-cap fibroatheroma and microchannel findings in optical coherence tomography correlate with subsequent progression of coronary atheromatous plaques http://www.medworm.com/index.php?rid=5559733&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F1%2F78%3Frss%3D1 Conclusion Optical coherence tomography-based complex characteristics of TCFA and microchannel were the potential predictors of subsequent progression of NSCPs in patients with CAD. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5559733 Sun, 01 Jan 2012 05:00:00 +0100 5559733 Computed tomography stress myocardial perfusion imaging in patients considered for revascularization: a comparison with fractional flow reserve http://www.medworm.com/index.php?rid=5559732&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F1%2F67%3Frss%3D1 Conclusion Computed tomography myocardial perfusion imaging is moderately accurate in identifying perfusion defects associated with ischaemia as assessed by FFR in patients considered for revascularization. In territories, where CTA and CTP are concordant, CTA/CTP is highly accurate in the detection and exclusion of ischaemia. This is achievable with acceptable radiation exposure using 320-detector row CT and prospective ECG gating. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5559732 Sun, 01 Jan 2012 05:00:00 +0100 5559732 Balloon dilatation of pulmonary artery banding: Norwegian experience over more than 20 years http://www.medworm.com/index.php?rid=5559731&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F1%2F61%3Frss%3D1 Conclusion We consider catheter debanding a valuable alternative in selected cases. Combination with additional interventional techniques may extend the future indications. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5559731 Sun, 01 Jan 2012 05:00:00 +0100 5559731 Aortic pseudo-aneurysm caused by complete dehiscence of the left coronary artery 7 years after a composite mechanical-valved conduit aortic root replacement (Bentall operation) http://www.medworm.com/index.php?rid=5559730&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F1%2F60%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5559730 Sun, 01 Jan 2012 05:00:00 +0100 5559730 Early invasive compared with a selective invasive strategy in women with non-ST-elevation acute coronary syndromes: a substudy of the OASIS 5 trial and a meta-analysis of previous randomized trials http://www.medworm.com/index.php?rid=5559729&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F1%2F51%3Frss%3D1 Conclusion The rate of death, MI, or stroke in women was not different in patients treated with a routine invasive strategy compared with a selective invasive strategy, but there was a concerning trend towards higher mortality. When combined with data from previous trials, there does not appear to be a benefit of an early invasive strategy in women with ACS, which differs from the results in men. These data emphasize the lack of clear evidence in favour of an invasive strategy in women and suggest caution in extrapolating the results from men to women. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5559729 Sun, 01 Jan 2012 05:00:00 +0100 5559729 Current management of left main coronary artery disease http://www.medworm.com/index.php?rid=5559728&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F1%2F36%3Frss%3D1 Coronary artery bypass surgery is considered as the gold standard treatment of unprotected left main coronary artery (ULMCA) disease. Over the last 20 years, improvement in stent technology and operators experience explained the increased number of reports on the results of percutaneous coronary interventions (PCIs) for the treatment of left main (LM) coronary artery lesion. The recent data comparing efficacy and safety of PCIs using drug-eluting stent and coronary artery bypass surgery showed comparable results in terms of safety and a lower need for repeat revascularization for coronary artery bypass surgery. Patient selection for both techniques is fundamental and directly impacts the clinical outcome. Further randomized trials must be conducted to precise the indications of both techni... European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5559728 Sun, 01 Jan 2012 05:00:00 +0100 5559728 Management of acute aortic syndromes http://www.medworm.com/index.php?rid=5559727&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F1%2F26%3Frss%3D1 Acute aortic syndrome (AAS) is a modern term to describe interrelated emergency aortic conditions with similar clinical characteristics and challenges. These conditions include aortic dissection, intramural haematoma (IMH), and penetrating atherosclerotic ulcer (PAU and aortic rupture); trauma to the aorta with intimal laceration may also be considered. The common denominator of AAS is disruption of the media layer of the aorta with bleeding within IMH, along the aortic media resulting in separation of the layers of the aorta (dissection), or transmurally through the wall in the case of ruptured PAU or trauma. Population-based studies suggest that the incidence of acute dissection ranges from 2 to 3.5 cases per 100 000 person-years; hypertension and a variety of genetic disorders with alte... European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5559727 Sun, 01 Jan 2012 05:00:00 +0100 5559727 From metallic cages to transient bioresorbable scaffolds: change in paradigm of coronary revascularization in the upcoming decade? http://www.medworm.com/index.php?rid=5559726&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F1%2F16%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5559726 Sun, 01 Jan 2012 05:00:00 +0100 5559726 Reduction of infarct size by ischaemic post-conditioning in humans: fact or fiction? http://www.medworm.com/index.php?rid=5559725&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F1%2F13%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5559725 Sun, 01 Jan 2012 05:00:00 +0100 5559725 In search of vulnerable features of coronary plaques with optical coherence tomography: is it time to rethink the current methodological concepts? http://www.medworm.com/index.php?rid=5559724&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F1%2F9%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5559724 Sun, 01 Jan 2012 05:00:00 +0100 5559724 CardioPulse Articles * Time will tell--are innovative approaches hastening and improving drug development? * The story of the heartbeat, I * Emigre experiences: Heinrich Shelbert MD, PhD * Heinrich Schelbert, an emigre in the land of opportunity * Revista Espanola de Cardiologia * Book review * Oxford Textbook of Heart Failure http://www.medworm.com/index.php?rid=5559723&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F33%2F1%2F1%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5559723 Sun, 01 Jan 2012 05:00:00 +0100 5559723 ESC Guidelines on the management of cardiovascular diseases during pregnancy: The Task Force on the Management of Cardiovascular Diseases during Pregnancy of the European Society of Cardiology (ESC) http://www.medworm.com/index.php?rid=5504525&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F24%2F3147%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5504525 Wed, 14 Dec 2011 05:00:00 +0100 5504525 People's corner: new local Associate Editor, EHJ * Brahmajee K. Nallamothu, MD, MPH http://www.medworm.com/index.php?rid=5504524&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F24%2F3146%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5504524 Wed, 14 Dec 2011 05:00:00 +0100 5504524 Acute pulmonary vasodilator response in paediatric and adult pulmonary arterial hypertension: occurrence and prognostic value when comparing three response criteria http://www.medworm.com/index.php?rid=5504523&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F24%2F3137%3Frss%3D1 Conclusion The proportion of patients with AVR highly depends on the used criteria, but did not differ between paediatric and adult iPAH/HPAH. Current response criteria are not suitable for patients with a post-tricuspid shunt. In both children and adults without post-tricuspid shunts, AVR was associated with improved survival independent of the used criteria. Nevertheless, prognostic value in the individual patient was limited. Baseline mRAP showed a good correlation with survival for adult PAH patients, but not for children. High baseline mPAP/mSAP and PVR/SVR was associated with worse prognosis independent from age, diagnosis, or the presence of a post-tricuspid shunt. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5504523 Wed, 14 Dec 2011 05:00:00 +0100 5504523 Similar outcome with an invasive strategy in men and women with non-ST-elevation acute coronary syndromes: From the Swedish Web-System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies (SWEDEHEART) http://www.medworm.com/index.php?rid=5504522&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F24%2F3128%3Frss%3D1 Conclusion In this large cohort of patients with NSTE ACS, reflecting real-life management, women and men had similar and better outcome associated with an invasive strategy. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5504522 Wed, 14 Dec 2011 05:00:00 +0100 5504522 SYNTAX score and Clinical SYNTAX score as predictors of very long-term clinical outcomes in patients undergoing percutaneous coronary interventions: a substudy of SIRolimus-eluting stent compared with pacliTAXel-eluting stent for coronary revascularization (SIRTAX) trial http://www.medworm.com/index.php?rid=5504521&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F24%2F3115%3Frss%3D1 Conclusion SYNTAX score and to a greater extent CSS were able to stratify risk for very long-term adverse clinical outcomes in an all-comers population receiving drug-eluting stents. Predictive accuracy for 5-year all-cause mortality was improved using CSS. Trial Registration Number: NCT00297661. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5504521 Wed, 14 Dec 2011 05:00:00 +0100 5504521 Hypertensive crisis and end-organ damage induced by over-the-counter nasal decongestant abuse http://www.medworm.com/index.php?rid=5504520&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F24%2F3114%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5504520 Wed, 14 Dec 2011 05:00:00 +0100 5504520 Gender differences in symptoms of myocardial ischaemia http://www.medworm.com/index.php?rid=5504519&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F24%2F3107%3Frss%3D1 Conclusion This prospective study with ECG-affirmed ischaemia found no statistically significant differences in women's and men's rates of chest and other typical symptoms during ischaemia, although women were more likely to experience throat and jaw discomfort. Currently both popular press and some patient education materials suggest women experience myocardial ischaemia differently from men. Steps to ensure women and health professionals are alert for the classic symptoms of myocardial ischaemia in women, as well as men, may be warranted. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5504519 Wed, 14 Dec 2011 05:00:00 +0100 5504519 Living on an atrial kick--an unusual case of a stuck mitral valve http://www.medworm.com/index.php?rid=5504518&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F24%2F3106%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5504518 Wed, 14 Dec 2011 05:00:00 +0100 5504518 Long-term prognosis associated with J-point elevation in a large middle-aged biracial cohort: the ARIC study http://www.medworm.com/index.php?rid=5504517&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F24%2F3098-a%3Frss%3D1 Conclusion Our results suggest that JPE is associated with an increased risk of SCD in whites and in females, but not in blacks or males. Further studies are needed to clarify which subgroups of individuals with JPE are at increased risk for adverse cardiac events. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5504517 Wed, 14 Dec 2011 05:00:00 +0100 5504517 Blood pressure tracking during pregnancy and the risk of gestational hypertensive disorders: The Generation R Study http://www.medworm.com/index.php?rid=5504516&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F24%2F3088%3Frss%3D1 Conclusion Blood pressure tracks moderately during pregnancy and is influenced by maternal characteristics. Second to third trimester increases in systolic and diastolic blood pressure are associated with an increased risk of gestational hypertensive disorders. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5504516 Wed, 14 Dec 2011 05:00:00 +0100 5504516 Beyond salt: lifestyle modifications and blood pressure http://www.medworm.com/index.php?rid=5504515&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F24%2F3081%3Frss%3D1 Lifestyle changes have been shown to effect significant blood pressure (BP) reductions. Although there are several proposed neurohormonal links between weight loss and BP, body mass index itself appears to be the most powerful mediator of the weight–BP relationship. There appears to be a mostly linear relationship between weight and BP; as weight is regained, the BP benefit is mostly lost. Physical activity, but more so physical fitness (the physiological benefit obtained from physical activity), has a dose-dependent BP benefit but reaches a plateau at which there is no further benefit. However, even just a modest physical activity can have a meaningful BP effect. A diet rich in fruits and vegetables with low-fat dairy products and low in saturated and total fat (DASH) is independent... European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5504515 Wed, 14 Dec 2011 05:00:00 +0100 5504515 Nutrition in cardiovascular disease: salt in hypertension and heart failure http://www.medworm.com/index.php?rid=5504514&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F24%2F3073%3Frss%3D1 There is much evidence for a causal relationship between salt intake and blood pressure (BP). The current salt intake in many countries is between 9 and 12 g/day. A reduction in salt intake to the recommended level of 5–6 g/day lowers BP in both hypertensive and normotensive individuals. A further reduction to 3–4 g/day has a much greater effect. Prospective studies and outcome trials have demonstrated that a lower salt intake is associated with a decreased risk of cardiovascular disease. Increasing evidence also suggests that a high salt intake is directly related to left ventricular hypertrophy (LVH) independent of BP. Both raised BP and LVH are important risk factors for heart failure. It is therefore possible that a lower salt intake could prevent the development of heart f... European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5504514 Wed, 14 Dec 2011 05:00:00 +0100 5504514 The Swedish paradox: or is there really no gender difference in acute coronary syndromes? http://www.medworm.com/index.php?rid=5504513&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F24%2F3070%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5504513 Wed, 14 Dec 2011 05:00:00 +0100 5504513 Can blood pressure in the first trimester predict the development of gestational hypertensive disorders? http://www.medworm.com/index.php?rid=5504512&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F24%2F3067%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5504512 Wed, 14 Dec 2011 05:00:00 +0100 5504512 Sex and gender differences in symptoms of myocardial ischaemia http://www.medworm.com/index.php?rid=5504511&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F24%2F3064%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5504511 Wed, 14 Dec 2011 05:00:00 +0100 5504511 How much of the world do you need for meaningful clinical trials? * Christmas Greetings 2011 * Book review: 'Cardiovascular catheterization and intervention' * A Textbook of Coronary, Peripheral, and Structural Heart Disease * The Brazilian Archives of Cardiology is the only cardiology journal in Latino America and the Southern hemisphere with an impact factor * The Mediterranean Diet, Part II * The TIMI story http://www.medworm.com/index.php?rid=5504510&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F24%2F3057%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5504510 Wed, 14 Dec 2011 05:00:00 +0100 5504510 CardioPulse Articles * The first ESC Guidelines on the management of cardiovascular diseases during pregnancy http://www.medworm.com/index.php?rid=5504509&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F24%2F3055%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5504509 Wed, 14 Dec 2011 05:00:00 +0100 5504509 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC) http://www.medworm.com/index.php?rid=5468563&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F23%2F2999%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5468563 Thu, 01 Dec 2011 05:00:00 +0100 5468563 Effect of upstream clopidogrel treatment in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention http://www.medworm.com/index.php?rid=5468562&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F23%2F2989%3Frss%3D1 Conclusion This large observational study suggests that upstream clopidogrel treatment prior to arrival at the catheterization lab is associated with a reduction in the combined risk of death or MI as well as death alone in patients with STEMI treated with primary PCI. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5468562 Thu, 01 Dec 2011 05:00:00 +0100 5468562 Normal chest radiograph and ground glass opacities on a thoracic computed tomographic scan in a patient with diffuse alveolar haemorrhage due to dual antiplatelet therapy prescribed after patent foramen ovale percutaneous device closure http://www.medworm.com/index.php?rid=5468561&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F23%2F2988%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5468561 Thu, 01 Dec 2011 05:00:00 +0100 5468561 Safety of clopidogrel being continued until the time of coronary artery bypass grafting in patients with acute coronary syndrome: a meta-analysis of 34 studies http://www.medworm.com/index.php?rid=5468560&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F23%2F2970%3Frss%3D1 Conclusion Previous studies focused on surrogate endpoints and compared higher risk ACS patients with elective cases. However, many patients have safely undergone CABG on clopidogrel and surgical expertise is growing. Multinational trials are required to fully determine the balance of ischaemia and bleeding. While results are awaited we suggest ACS patients requiring urgent CABG proceed with surgery without delay for a clopidogrel-free period. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5468560 Thu, 01 Dec 2011 05:00:00 +0100 5468560 Aspirin for primary prevention of vascular events in women: individualized prediction of treatment effects http://www.medworm.com/index.php?rid=5468559&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F23%2F2962%3Frss%3D1 Conclusion Aspirin was ineffective or even harmful in the majority of patients. Age was positively related to treatment effect, whereas current smoking and baseline risk for cardiovascular events were not. When the NWT is 50 or lower, the aspirin treatment strategy that is associated with optimal net benefit in primary prevention of vascular events in women is to treat none. Trial registration information: Clinicaltrials.gov identifier number: NCT00000479. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5468559 Thu, 01 Dec 2011 05:00:00 +0100 5468559 Clopidogrel pre-treatment is associated with reduced in-hospital mortality in primary percutaneous coronary intervention for acute ST-elevation myocardial infarction http://www.medworm.com/index.php?rid=5468558&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F23%2F2954%3Frss%3D1 Conclusion Clopidogrel pre-treatment before arrival at the PCI centre is associated with reduced mortality in a real world setting of primary PCI. These results strongly support the recommendation of clopidogrel treatment ‘as soon as possible’ in patients with STEMI undergoing pimary PCI. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5468558 Thu, 01 Dec 2011 05:00:00 +0100 5468558 Characterization of dyspnoea in PLATO study patients treated with ticagrelor or clopidogrel and its association with clinical outcomes http://www.medworm.com/index.php?rid=5468557&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F23%2F2945%3Frss%3D1 Conclusions Ticagrelor-related dyspnoea is usually mild or moderate in intensity and does not appear to be associated with differences concerning any efficacy or safety outcomes with ticagrelor compared with clopidogrel therapy in ACS patients. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5468557 Thu, 01 Dec 2011 05:00:00 +0100 5468557 Bleeding complications with the P2Y12 receptor antagonists clopidogrel and ticagrelor in the PLATelet inhibition and patient Outcomes (PLATO) trial http://www.medworm.com/index.php?rid=5468556&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F23%2F2933%3Frss%3D1 Conclusion Ticagrelor compared with clopidogrel was associated with similar total major bleeding but increased non-CABG and non-procedure-related major bleeding, primarily after 30 days on study drug treatment. Fatal bleeding was low and did not differ between groups. Trial registration information: Clinicaltrials.gov identifier number: NCT00391872. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5468556 Thu, 01 Dec 2011 05:00:00 +0100 5468556 Antiplatelet agents for the treatment and prevention of atherothrombosis http://www.medworm.com/index.php?rid=5468555&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F23%2F2922%3Frss%3D1 The clinical pharmacology of antiplatelet drugs has been reviewed previously by the European Society of Cardiology (ESC) Task force and by the 8th American College of Chest Physicians (ACCP) Evidence-Based Clinical Practice Guidelines. Moreover, information on the efficacy and safety of antiplatelet drugs in the treatment and prevention of atherothrombosis is provided by collaborative meta-analyses of 287 secondary prevention trials and 6 primary prevention trials. The present document intends to provide practicing physicians with an updated instrument to guide their choice of the most suitable antiplatelet strategy for the individual patient at risk, or with different clinical manifestations, of atherothrombosis. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5468555 Thu, 01 Dec 2011 05:00:00 +0100 5468555 No free lunches: balancing bleeding and efficacy with ticagrelor http://www.medworm.com/index.php?rid=5468554&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F23%2F2919%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5468554 Thu, 01 Dec 2011 05:00:00 +0100 5468554 Mitochondria and the heart * People's corner award: Thomas Thum * Outstanding Achievement Award from the ESC Council for Basic Cardiovascular Science * Book review * Evidence-based Management of Hypertension * Felix Zijlstra, head of cardiology at the Thoraxcenter Erasmus * Heart Lung and Circulation Journal * Percutaneous coronary intervention for vascular erectile dysfunction: a new area for cardiologists? * The Mediterranean diet, Part I http://www.medworm.com/index.php?rid=5468553&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F23%2F2911%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5468553 Thu, 01 Dec 2011 05:00:00 +0100 5468553 CardioPulse Articles * Updated ESC Guidelines for managing patients with suspected non-ST-elevation acute coronary syndromes http://www.medworm.com/index.php?rid=5468552&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F23%2F2909%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5468552 Thu, 01 Dec 2011 05:00:00 +0100 5468552 Bilateral percutaneous pulmonary valve implantation in dual conduits from the subpulmonary ventricle to the pulmonary arteries http://www.medworm.com/index.php?rid=5407469&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F22%2F2907%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5407469 Mon, 14 Nov 2011 05:00:00 +0100 5407469 ESC Guidelines on the diagnosis and treatment of peripheral artery diseases: Document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteries * The Task Force on the Diagnosis and Treatment of Peripheral Artery Diseases of the European Society of Cardiology (ESC) http://www.medworm.com/index.php?rid=5407468&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F22%2F2851%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5407468 Mon, 14 Nov 2011 05:00:00 +0100 5407468 Wnt pathway activation, cell migration, and lipid uptake is regulated by low-density lipoprotein receptor-related protein 5 in human macrophages http://www.medworm.com/index.php?rid=5407467&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F22%2F2841%3Frss%3D1 Conclusion These results demonstrate the involvement of LRP5 in the innate inflammatory reaction to lipid infiltration in atherosclerosis. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5407467 Mon, 14 Nov 2011 05:00:00 +0100 5407467 Isolated arrhythmogenic left ventricular cardiomyopathy identified by cardiac magnetic resonance imaging http://www.medworm.com/index.php?rid=5407466&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F22%2F2840%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5407466 Mon, 14 Nov 2011 05:00:00 +0100 5407466 Injectable living marrow stromal cell-based autologous tissue engineered heart valves: first experiences with a one-step intervention in primates http://www.medworm.com/index.php?rid=5407465&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F22%2F2830%3Frss%3D1 Conclusion Here, we provide a novel concept demonstrating that heart valve tissue engineering based on a minimally invasive technique for both cell harvest and valve delivery as a one-step intervention is feasible in non-human primates. This innovative approach may overcome the limitations of contemporary surgical and interventional bioprosthetic heart valve prostheses. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5407465 Mon, 14 Nov 2011 05:00:00 +0100 5407465 Impact of cardiac hybrid single-photon emission computed tomography/computed tomography imaging on choice of treatment strategy in coronary artery disease http://www.medworm.com/index.php?rid=5407464&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F22%2F2824%3Frss%3D1 Conclusion Cardiac hybrid imaging with SPECT and CCTA provides an added clinical value for decision making with regard to treatment strategy for CAD. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5407464 Mon, 14 Nov 2011 05:00:00 +0100 5407464 Coronary CT angiographic characteristics of culprit lesions in acute coronary syndromes not related to plaque rupture as defined by optical coherence tomography and angioscopy http://www.medworm.com/index.php?rid=5407463&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F22%2F2814%3Frss%3D1 Conclusion In contrast to the situation with RFC-ACS, distinct culprit lesion characteristics associated with non-rupture-related mechanisms are not identified by CT angiography. It will therefore not be possible to differentiate plaques likely to develop IFC-ACS from stable plaques. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5407463 Mon, 14 Nov 2011 05:00:00 +0100 5407463 Influence of left ventricular geometry and function on aortic annular dimensions as assessed with multi-detector row computed tomography: implications for transcatheter aortic valve implantation http://www.medworm.com/index.php?rid=5407462&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F22%2F2806%3Frss%3D1 Conclusion In severe AS patients, the presence of LV dysfunction, not the presence of severe AS, was an independent determinant of a larger aortic annular diameter. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5407462 Mon, 14 Nov 2011 05:00:00 +0100 5407462 Venous thromboembolism does not share strong familial susceptibility with coronary heart disease: a nationwide family study in Sweden http://www.medworm.com/index.php?rid=5407461&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F22%2F2800%3Frss%3D1 Conclusion The familial background of CHD is different from that of VTE. The present study suggests that it is unlikely that shared disease-causing mutations exist to a large extent in the population. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5407461 Mon, 14 Nov 2011 05:00:00 +0100 5407461 Iron deficiency is associated with adverse outcome in Eisenmenger patients http://www.medworm.com/index.php?rid=5407460&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F22%2F2790%3Frss%3D1 Conclusions Iron deficiency was associated with a higher risk of adverse outcome. Moreover, the use of oral anticoagulation OAC and frequent phlebotomies were related to iron deficiency. Patients under anticoagulation should be monitored rigorously for iron deficiency. However, in patients with low oxygen saturations, careful iron substitution to avoid too high haemoglobin levels is suggested. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5407460 Mon, 14 Nov 2011 05:00:00 +0100 5407460 Dabigatran vs. placebo in patients with acute coronary syndromes on dual antiplatelet therapy: a randomized, double-blind, phase II trial http://www.medworm.com/index.php?rid=5407459&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F22%2F2781%3Frss%3D1 Conclusions Dabigatran, in addition to dual antiplatelet therapy, was associated with a dose-dependent increase in bleeding events and significantly reduced coagulation activity in patients with a recent myocardial infarction. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5407459 Mon, 14 Nov 2011 05:00:00 +0100 5407459 Cardiovascular disease risk factors in relation to suicide mortality in Asia: prospective cohort study of over one million Korean men and women http://www.medworm.com/index.php?rid=5407458&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F22%2F2773%3Frss%3D1 Conclusion In this cohort of Korean men and women, a series of CVD risk factors were associated with an elevated risk of future suicide mortality. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5407458 Mon, 14 Nov 2011 05:00:00 +0100 5407458 Silent myocardial ischaemia and long-term coronary artery disease outcomes in apparently healthy people from families with early-onset ischaemic heart disease http://www.medworm.com/index.php?rid=5407457&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F22%2F2766%3Frss%3D1 Conclusion Inducible ischaemia is highly prevalent in male siblings, suggesting a previously unknown long quiescent period before the occurrence of a clinical event. While inducible ischaemia is associated with a worse prognosis, male siblings with negative tests still bear a high risk of incident disease, such that we propose that in male siblings over 40 years of age, aggressive primary prevention interventions be instituted without nuclear testing. For women, the prevalence of ischaemia was so low as to not warrant screening, but the incidence of CAD was high enough to at least warrant lifestyle interventions. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5407457 Mon, 14 Nov 2011 05:00:00 +0100 5407457 Myocardial ischaemia in patients with coronary endothelial dysfunction: insights from body surface ECG mapping and implications for invasive evaluation of chronic chest pain http://www.medworm.com/index.php?rid=5407456&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F22%2F2758%3Frss%3D1 Conclusions This study demonstrates that abnormal vasomotion due to coronary ED is associated with myocardial ischaemia in patients with chest pain. The magnitude of ischaemia correlates with the extent of ED. A small subset of patients develop myocardial ischaemia during ACH infusion without significant abnormalities in epicardial or global microvascular endothelium-dependent blood flow responses. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5407456 Mon, 14 Nov 2011 05:00:00 +0100 5407456 Cardiac hybrid imaging in a patient with a single coronary artery originating from the right sinus of Valsalva http://www.medworm.com/index.php?rid=5407455&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F22%2F2757%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5407455 Mon, 14 Nov 2011 05:00:00 +0100 5407455 Current concepts on coronary revascularization in diabetic patients http://www.medworm.com/index.php?rid=5407454&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F22%2F2748%3Frss%3D1 Diabetic mellitus (DM) patients with coronary artery disease (CAD) are at higher risk of cardiovascular events compared with non-DM individuals. While aggressive cardiovascular prevention and adequate blood glucose control remain cornerstones of therapy, the decision when and how to proceed to coronary revascularization in an individual DM patient should be based on the extent of CAD, ischaemic burden, ventricular function, as well as comorbidities. While in patients with stable symptoms, moderate CAD on coronary angiography and preserved left ventricular function a conservative strategy may be a valuable initial strategy, in patients with acute coronary syndromes (ACS) an early invasive approach should be favoured. The revascularization strategy for DM patients with complex multivessel CA... European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5407454 Mon, 14 Nov 2011 05:00:00 +0100 5407454 Therapeutic perspectives in hypertension: novel means for renin-angiotensin-aldosterone system modulation and emerging device-based approaches http://www.medworm.com/index.php?rid=5407453&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F22%2F2739%3Frss%3D1 The conventional antihypertensive therapies including renin–angiotensin–aldosterone system antagonists (converting enzyme inhibitors, receptor blockers, renin inhibitors, and mineralocorticoid receptor blockers), diuretics, β-blockers, and calcium channel blockers are variably successful in achieving the challenging target blood pressure values in hypertensive patients. Difficult to treat hypertension is still a commonly observed problem world-wide. A number of drugs are considered to be used as novel therapies for hypertension. Renalase supplementation, vasopeptidase inhibitors, endothelin antagonists, and especially aldosterone antagonists (aldosterone synthase inhibitors and novel selective mineralocorticoid receptor blockers) are considered an option in resistant hyper... European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5407453 Mon, 14 Nov 2011 05:00:00 +0100 5407453 Failure of CT coronary imaging to identify plaque erosion: a resetting of expectations http://www.medworm.com/index.php?rid=5407452&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F22%2F2736%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5407452 Mon, 14 Nov 2011 05:00:00 +0100 5407452 Redemption by RE-DEEM? http://www.medworm.com/index.php?rid=5407451&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F22%2F2734%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5407451 Mon, 14 Nov 2011 05:00:00 +0100 5407451 Japan tops abstract submissions to ESC Congress * Alec Vahanian new International Associate editor for EHJ * Corrigenda * Identifying acute coronary syndromes from a single measure of plasma lipids? * Book review * Three-dimensional Echocardiography * Cardiology Research in Lebanon * From pacemakers to pumps * Personal experiences of emigre cardiologist: Salim Yusuf * East to west * The polypill concept: the future http://www.medworm.com/index.php?rid=5407450&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F22%2F2725%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5407450 Mon, 14 Nov 2011 05:00:00 +0100 5407450 CardioPulse Articles * The European Society of Cardiology publishes its first Guidelines on peripheral artery diseases http://www.medworm.com/index.php?rid=5407449&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F22%2F2723%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5407449 Mon, 14 Nov 2011 05:00:00 +0100 5407449 Fibroblast activation protein is induced by inflammation and degrades type I collagen in thin-cap fibroatheromata http://www.medworm.com/index.php?rid=5385851&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F21%2F2713%3Frss%3D1 Conclusion Fibroblast activation protein expression in HASMC is induced by macrophage-derived TNFα. Fibroblast activation protein associates with thin-cap human coronary fibroatheromata and contributes to type I collagen breakdown in fibrous caps. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5385851 Tue, 01 Nov 2011 04:00:00 +0100 5385851 Giant right coronary aneurysm: a case of mistaken identity http://www.medworm.com/index.php?rid=5385850&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F21%2F2712%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5385850 Tue, 01 Nov 2011 04:00:00 +0100 5385850 Clinical outcome of renal tubular damage in chronic heart failure http://www.medworm.com/index.php?rid=5385849&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F21%2F2705%3Frss%3D1 Conclusion Tubular damage is related to a poor clinical outcome in HF patients even when eGFR is normal. ClinicalTrials.gov Identifier: NCT00336336 (for the main study). (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5385849 Tue, 01 Nov 2011 04:00:00 +0100 5385849 Clinical course and outcome of patients enrolled in US and non-US centres in MADIT-CRT http://www.medworm.com/index.php?rid=5385848&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F21%2F2697%3Frss%3D1 Conclusion Patients enrolled in US and non-US centres in MADIT-CRT displayed significant differences in baseline clinical and echocardiographic characteristics and in the frequency of procedure-related complications, but experienced an overall similar clinical and echocardiographic response to CRT-D. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5385848 Tue, 01 Nov 2011 04:00:00 +0100 5385848 The phosphatonin fibroblast growth factor 23 links calcium-phosphate metabolism with left-ventricular dysfunction and atrial fibrillation http://www.medworm.com/index.php?rid=5385847&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F21%2F2688%3Frss%3D1 Conclusions Fibroblast growth factor 23 levels are associated with left-ventricular function and atrial fibrillation even in the absence of renal function impairment. Of note, these cross-sectional data cannot prove causality; therefore, future studies will have to discern whether FGF-23 exerts a direct untoward effect on the myocardium, or rather represents an ‘innocent bystander’ which reflects a high phosphate burden. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5385847 Tue, 01 Nov 2011 04:00:00 +0100 5385847 Driving restrictions after implantable cardioverter defibrillator implantation: an evidence-based approach http://www.medworm.com/index.php?rid=5385846&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F21%2F2678%3Frss%3D1 Conclusion The current analysis provides a clinically applicable tool for guideline committees to establish evidence-based driving restrictions. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5385846 Tue, 01 Nov 2011 04:00:00 +0100 5385846 Heart health when life is satisfying: evidence from the Whitehall II cohort study http://www.medworm.com/index.php?rid=5385845&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F21%2F2672%3Frss%3D1 Conclusions Satisfaction in most life domains was associated with reduced CHD risk, with definite angina being mostly responsible for this association. These findings suggest that satisfaction with life may promote heart health. Further research should examine whether interventions to enhance life satisfaction in specific domains reduce CHD risk and whether life satisfaction is primarily associated with atherosclerosis rather than thrombotic factors associated with plaque rupture. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5385845 Tue, 01 Nov 2011 04:00:00 +0100 5385845 Combustion-derived nanoparticulate induces the adverse vascular effects of diesel exhaust inhalation http://www.medworm.com/index.php?rid=5385844&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F21%2F2660%3Frss%3D1 Conclusion Combustion-derived nanoparticulate appears to predominately mediate the adverse vascular effects of diesel exhaust inhalation. This provides a rationale for testing environmental health interventions targeted at reducing traffic-derived particulate emissions. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5385844 Tue, 01 Nov 2011 04:00:00 +0100 5385844 Fatal late prosthetic aortic valve endocarditis http://www.medworm.com/index.php?rid=5385843&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F21%2F2659%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5385843 Tue, 01 Nov 2011 04:00:00 +0100 5385843 Efficacy of apolipoprotein B synthesis inhibition in subjects with mild-to-moderate hyperlipidaemia http://www.medworm.com/index.php?rid=5385842&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F21%2F2650%3Frss%3D1 Conclusions Mipomersen administered as monotherapy in subjects with mild-to-moderate hyperlipidaemia produced potent reductions in all apoB-containing lipoproteins. Higher doses were associated with hepatic trans-aminase increases. This trial is registered at clinicaltrials.gov as NCT00216463. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5385842 Tue, 01 Nov 2011 04:00:00 +0100 5385842 Associations of plasma renin with 10-year cardiovascular mortality, sudden cardiac death, and death due to heart failure http://www.medworm.com/index.php?rid=5385841&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F21%2F2642%3Frss%3D1 Conclusions Plasma renin concentration is associated with long-term cardiovascular mortality in patients referred to coronary angiography. Further intervention studies should determine whether renin is a potential therapeutic target or only a marker of mortality risk in various cardiovascular risk groups. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5385841 Tue, 01 Nov 2011 04:00:00 +0100 5385841 Induced pluripotent stem cell (iPSC)-derived Flk-1 progenitor cells engraft, differentiate, and improve heart function in a mouse model of acute myocardial infarction http://www.medworm.com/index.php?rid=5385840&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F21%2F2634%3Frss%3D1 Conclusion iPSC-derived Flk-1pos progenitor cells differentiate into cardiovascular lineages in vitro and in vivo and improve cardiac function after acute MI. This proof of concept study paves the way for an autologous iPSC-based therapy of MI. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5385840 Tue, 01 Nov 2011 04:00:00 +0100 5385840 Mineralocorticoid receptor antagonism: therapeutic potential in acute heart failure syndromes http://www.medworm.com/index.php?rid=5385839&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F21%2F2626%3Frss%3D1 Acute heart failure syndromes (AHFS) are a heterogeneous group of commonly encountered and difficult to manage clinical syndromes associated with high morbidity and mortality. Dyspnoea, pulmonary, and systemic congestion often characterize AHFS due to acutely elevated intracardiac filling pressures and fluid overload. Diuresis, respiratory support, vasodilator therapy, and gradual attenuation of the activation of renin–angiotensin–aldosterone system (RAAS) and sympathetic nervous system (SNS) are the keystones of AHFS management. Despite available therapies, post-discharge mortality and re-hospitalization rates remain unacceptably high in AHFS. Neurohumoral-mediated cardiorenal dysfunction and congestion may contribute to these high event rates. Mineralocorticoid receptor antag... European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5385839 Tue, 01 Nov 2011 04:00:00 +0100 5385839 Hybrid cardiac magnetic resonance/computed tomographic imaging: first fusion of three-dimensional magnetic resonance perfusion and low-dose coronary computed tomographic angiography http://www.medworm.com/index.php?rid=5385838&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F21%2F2625%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5385838 Tue, 01 Nov 2011 04:00:00 +0100 5385838 The management of myocarditis http://www.medworm.com/index.php?rid=5385837&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F21%2F2616%3Frss%3D1 Despite considerable advances in our understanding of myocarditis pathogenesis, the clinical management of myocarditis has changed relatively little in the last few years. This review aims to help bridge the widening gap between recent mechanistic insights, which are largely derived from animal models, and their potential impact on disease burden. We illustrate the pathogenenic mechanisms that are prime targets for novel therapeutic interventions. Pathway and pathogen-specific molecular diagnostic tests have expanded the role for endomyocardial biopsy. State of the art cardiac magnetic resonance imaging can now provide non-invasive tissue characterization and localize inflammatory infiltrates but imaging techniques are misleading if infectious agents are involved. We emphasize the gaps in ... European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5385837 Tue, 01 Nov 2011 04:00:00 +0100 5385837 From bench to policies: ready for a nanoparticle air quality standard? http://www.medworm.com/index.php?rid=5385836&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F21%2F2613%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5385836 Tue, 01 Nov 2011 04:00:00 +0100 5385836 More about plasma renin and cardiovascular mortality http://www.medworm.com/index.php?rid=5385835&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F21%2F2610%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5385835 Tue, 01 Nov 2011 04:00:00 +0100 5385835 Elite European Heart Journal Reviewers, 2011 * Five studies from HOT LINE I, European Society of Cardiology Congress 2011, Paris * HOT LINE II from ESC Congress 2011, Paris * HOT LINE III from ESC Congress 2011, Paris * ESC Congress: Clinical trials update sessions * Clinical registry updates from the European Society of Cardiology Congress 2011 http://www.medworm.com/index.php?rid=5385834&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F21%2F2594%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5385834 Tue, 01 Nov 2011 04:00:00 +0100 5385834 CardioPulse Articles * Together we made it! * The oldest medical journal in continuous publication * Sir James Black FRS (1924-2010): Nobel Prize winner and pioneer in cardiology * Cardiologists find evidence why too much exercise might be bad for you * Sudden cardiac death in marathon runners: can it be prevented? http://www.medworm.com/index.php?rid=5385833&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F21%2F2585%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5385833 Tue, 01 Nov 2011 04:00:00 +0100 5385833 Dietary {alpha}-linolenic acid diminishes experimental atherogenesis and restricts T cell-driven inflammation http://www.medworm.com/index.php?rid=5314141&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F20%2F2573%3Frss%3D1 Conclusion Dietary ALA diminishes experimental atherogenesis and restricts T cell-driven inflammation, thus providing the proof-of-principle that plant-derived ALA may provide a valuable alternative to marine LC n–3 FA. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5314141 Fri, 14 Oct 2011 04:00:00 +0100 5314141 Shamrock aorta: unruptured sinus of Valsalva aneurysms in a patient with a prosthetic heart valve http://www.medworm.com/index.php?rid=5314140&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F20%2F2572%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5314140 Fri, 14 Oct 2011 04:00:00 +0100 5314140 Changes in renal function during hospitalization and soon after discharge in patients admitted for worsening heart failure in the placebo group of the EVEREST trial http://www.medworm.com/index.php?rid=5314139&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F20%2F2563%3Frss%3D1 Conclusion The prevalence of renal dysfunction is high in patients hospitalized for HF with reduced LVEF. Worsening renal function may occur not only during hospitalization, but also in the early post-discharge period. Since worsening renal function during hospitalization is associated with a significant decrease in signs and symptoms of congestion, body weight and natriuretic peptides, which are good prognostic indicators, worsening renal function during hospitalization as an endpoint in clinical trials should be re-evaluated. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5314139 Fri, 14 Oct 2011 04:00:00 +0100 5314139 Patients using vitamin K antagonists show increased levels of coronary calcification: an observational study in low-risk atrial fibrillation patients http://www.medworm.com/index.php?rid=5314138&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F20%2F2555%3Frss%3D1 Conclusion Patients using VKA show increased levels of coronary calcification. Age and VKA treatment were independently related to increased coronary calcium score. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5314138 Fri, 14 Oct 2011 04:00:00 +0100 5314138 RUBY-1: a randomized, double-blind, placebo-controlled trial of the safety and tolerability of the novel oral factor Xa inhibitor darexaban (YM150) following acute coronary syndrome http://www.medworm.com/index.php?rid=5314137&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F20%2F2541%3Frss%3D1 Conclusions Darexaban when added to dual antiplatelet therapy after ACS produces an expected dose-related two- to four-fold increase in bleeding, with no other safety concerns but no signal of efficacy. Establishing the potential of low-dose darexaban in preventing major cardiac events after ACS requires a large phase III trial. ClinicalTrials.gov Identifier: NCT00994292 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5314137 Fri, 14 Oct 2011 04:00:00 +0100 5314137 Biventricular pacing is superior to right ventricular pacing in bradycardia patients with preserved systolic function: 2-year results of the PACE trial http://www.medworm.com/index.php?rid=5314136&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F20%2F2533%3Frss%3D1 Conclusion Left ventricular adverse remodelling and deterioration of systolic function continues at the second year after RVA pacing. This deterioration is prevented by BiV pacing. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5314136 Fri, 14 Oct 2011 04:00:00 +0100 5314136 The Anglo-Scandinavian Cardiac Outcomes Trial: 11-year mortality follow-up of the lipid-lowering arm in the UK http://www.medworm.com/index.php?rid=5314135&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F20%2F2525%3Frss%3D1 Conclusion Legacy effects of those originally assigned atorvastatin may contribute to long-term benefits on all-cause mortality. An explanation for long-term benefits on non-CV deaths has not been established. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5314135 Fri, 14 Oct 2011 04:00:00 +0100 5314135 Double mechanical prosthesis, correct international normalized ratio, and giant atrial mass http://www.medworm.com/index.php?rid=5314134&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F20%2F2524%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5314134 Fri, 14 Oct 2011 04:00:00 +0100 5314134 The relationship between ventricular electrical delay and left ventricular remodelling with cardiac resynchronization therapy http://www.medworm.com/index.php?rid=5314133&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F20%2F2516%3Frss%3D1 Conclusion Electrical dyssynchrony, as measured by QLV, was strongly and independently associated with reverse remodelling and QOL with CRT. Acute measurements of QLV may be useful to guide LV lead placement. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5314133 Fri, 14 Oct 2011 04:00:00 +0100 5314133 Effects of selective heart rate reduction with ivabradine on left ventricular remodelling and function: results from the SHIFT echocardiography substudy http://www.medworm.com/index.php?rid=5314132&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F20%2F2507%3Frss%3D1 Conclusion Ivabradine reverses cardiac remodelling in patients with HF and LV systolic dysfunction. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5314132 Fri, 14 Oct 2011 04:00:00 +0100 5314132 Hypertension management 2011: optimal combination therapy http://www.medworm.com/index.php?rid=5314131&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F20%2F2499%3Frss%3D1 Raised levels of blood pressure result from the complex interplay of environmental and genetic factors. The complexity of blood pressure control mechanisms has major implications for individual responsiveness to antihypertensive drugs. The underlying haemodynamic disorder in the majority of cases is a rise in peripheral vascular resistance. This observation led to the discovery and development of increasingly sophisticated and targeted vasodilators, although many of the earlier antihypertensive drugs, by virtue of their actions blocking the sympathetic nervous system, had a vasodilator component to their mode of action. A recent meta-analysis of placebo controlled trials of monotherapy in unselected hypertensives, reports average (placebo-corrected) blood pressure responses to single agent... European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5314131 Fri, 14 Oct 2011 04:00:00 +0100 5314131 Rupturing aortic dissection http://www.medworm.com/index.php?rid=5314130&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F20%2F2498%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5314130 Fri, 14 Oct 2011 04:00:00 +0100 5314130 Early detection of pulmonary vascular disease in pulmonary arterial hypertension: time to move forward http://www.medworm.com/index.php?rid=5314129&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F20%2F2489%3Frss%3D1 Pulmonary arterial hypertension (PAH) can be a rapidly progressive disorder and is associated with high rate of mortality, despite medical intervention. With the availability of effective therapy, early disease detection is an important strategic objective to improve treatment outcomes. Resting echocardiography is currently the recommended screening modality for high-risk population groups. However, it is clear that derangements in resting haemodynamics (and symptoms) are late sequelae of the pathobiological processes that begin in the distal pulmonary arteries. Exercise stress may unmask early pulmonary vascular dysfunction but the definition, clinical significance, and natural history of ‘exercise PAH’ remain undefined. We will review the currently available and potential fut... European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5314129 Fri, 14 Oct 2011 04:00:00 +0100 5314129 A marker of mayhem: macrovolt T-wave alternans preceding polymorphic ventricular tachycardia http://www.medworm.com/index.php?rid=5314128&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F20%2F2488%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5314128 Fri, 14 Oct 2011 04:00:00 +0100 5314128 On the cutting edge of acute coronary syndromes: adding oral factor Xa-inhibition with darexaban to dual antiplatelet therapy: the RUBY-1 trial http://www.medworm.com/index.php?rid=5314127&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F20%2F2486%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5314127 Fri, 14 Oct 2011 04:00:00 +0100 5314127 Chronic right ventricular pacing, adverse remodelling, and CRT: an ounce of prevention? http://www.medworm.com/index.php?rid=5314126&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F20%2F2483%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5314126 Fri, 14 Oct 2011 04:00:00 +0100 5314126 Left ventricular remodelling in systolic heart failure using ivabradine. Slower is smaller is better? http://www.medworm.com/index.php?rid=5314125&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F20%2F2481%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5314125 Fri, 14 Oct 2011 04:00:00 +0100 5314125 Long-term results from statin trials: answers but more unresolved questions http://www.medworm.com/index.php?rid=5314124&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F20%2F2479%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5314124 Fri, 14 Oct 2011 04:00:00 +0100 5314124 Worsening kidney function in decompensated heart failure: treat the heart, don't mind the kidney http://www.medworm.com/index.php?rid=5314123&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F20%2F2476%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5314123 Fri, 14 Oct 2011 04:00:00 +0100 5314123 Long-term application of vitamin K antagonists, more harm than good? The additional value of imaging http://www.medworm.com/index.php?rid=5314122&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F20%2F2473%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5314122 Fri, 14 Oct 2011 04:00:00 +0100 5314122 CardioPulse Articles * The ESC Working Group on Acute Cardiac Care * Biomarkers for health, and overall life expectancy, are becoming more and more accurate * The Atherosclerosis journal * Book review * When Your Spouse Has a Stroke * Country differences in preventative treatments * Is age alone suitable screening for cardiovascular preventive treatment? * The polypill concept: the story so far http://www.medworm.com/index.php?rid=5314121&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F20%2F2465%3Frss%3D1 (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5314121 Fri, 14 Oct 2011 04:00:00 +0100 5314121 Tissue coverage of a hydrophilic polymer-coated zotarolimus-eluting stent vs. a fluoropolymer-coated everolimus-eluting stent at 13-month follow-up: an optical coherence tomography substudy from the RESOLUTE All Comers trial http://www.medworm.com/index.php?rid=5273461&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F19%2F2454%3Frss%3D1 Conclusion No significant differences in tissue coverage, malapposition, or lumen/stent areas and volumes were detected by OCT between the hydrophilic polymer-coated ZES and the fluoropolymer-coated EES at 13-month follow-up. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5273461 Sat, 01 Oct 2011 04:00:00 +0100 5273461 Maternal cigarette smoking is associated with reduced high-density lipoprotein cholesterol in healthy 8-year-old children http://www.medworm.com/index.php?rid=5273460&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F19%2F2446%3Frss%3D1 Conclusion Smoking in pregnancy is independently associated with significantly lower HDL cholesterol in healthy 8-year-old children. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5273460 Sat, 01 Oct 2011 04:00:00 +0100 5273460 Non-invasive estimation of pulmonary vascular resistance with cardiac magnetic resonance http://www.medworm.com/index.php?rid=5273459&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F19%2F2438%3Frss%3D1 Conclusions Non-invasive estimation of PVR using CMR is feasible and may be valuable for PH diagnosis and/or follow-up. (Source: European Heart Journal) European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5273459 Sat, 01 Oct 2011 04:00:00 +0100 5273459 Increased risk of atrial fibrillation in patients with coeliac disease: a nationwide cohort study http://www.medworm.com/index.php?rid=5273458&cid=s_29161_7_f&fid=29161&url=http%3A%2F%2Feurheartj.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F32%2F19%2F2430%3Frss%3D1 Conclusions Atrial fibrillation is more common both before and after CD diagnosis in patients with CD though the excess risk is small. Potential explanations for the increased risk of AF in CD include chronic inflammation and shared risk factors, but ascertainment bias may also have contributed. Clinical implications Coeliac disease affects 1–2% of the Western population. Our results indicate that patients with coeliac disease, verified by intestinal biopsy, are at increased risk of atrial fibrillation. This observation is consistent with previous findings that elevation of inflammatory markers predicts atrial fibrillation. Additional studies are needed to clarify the mechanistic link between atrial fibrillation and autoimmune diseases such as coeliac disease. (Source: European Hear... European Heart Journal journals http://www.medworm.com/rss/comments.php?id=5273458 Sat, 01 Oct 2011 04:00:00 +0100 5273458