MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'European Journal of Clinical Investigation' source. Wed, 08 Feb 2012 18:50:21 +0100 http://www.medworm.com/index.php?rid=5664670&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02587.x Conclusion  Our results indicate that high TGF‐β1 content in human atherosclerotic plaques and high serum levels of TGF‐β1 are not associated with reduced risk of coronary events. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5664670 Tue, 07 Feb 2012 02:06:30 +0100 5664670 http://www.medworm.com/index.php?rid=5664669&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02586.x Conclusion  Our results suggest that circulating visfatin levels correlate with WBC and CRP but are not associated with PCOS, obesity or metabolic markers, suggesting that visfatin may act as a proinflammatory cytokine. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5664669 Tue, 07 Feb 2012 02:06:28 +0100 5664669 http://www.medworm.com/index.php?rid=5664668&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02582.x Conclusions  The present lipid infusion protocol appears to be safe and well tolerated and provides significant incorporation of n‐3 PUFAs into plasma phospholipids and PBMCs. In the absence of overt inflammation, no direct effects of FO were observed on immune function or (anti)oxidant balance. This model may be useful to evaluate effects of parenteral lipids in other settings, for example in individuals displaying an inflammatory state. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5664668 Tue, 07 Feb 2012 02:06:22 +0100 5664668 http://www.medworm.com/index.php?rid=5664667&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02581.x Conclusion  Endotoxemia affects the bioavailability of AAs differently according to the amino acid considered. This feature may be important for nutritional strategy in ICU patients. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5664667 Tue, 07 Feb 2012 02:06:20 +0100 5664667 http://www.medworm.com/index.php?rid=5664666&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02580.x Conclusions  This study provides evidence of an increased prevalence of anatomic and functional adrenal alterations in patients with acromegaly; further studies will clarify the importance of evaluating these subjects with baseline hormonal investigation along with dynamic testing and modified cut‐offs. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5664666 Tue, 07 Feb 2012 02:06:19 +0100 5664666 http://www.medworm.com/index.php?rid=5664665&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02579.x Conclusions  Concomitant use of CCBs as a class did not modify the protective effect of clopidogrel and was not associated with increased cardiovascular risk among patients using clopidogrel after coronary stent implantation. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5664665 Tue, 07 Feb 2012 02:06:17 +0100 5664665 http://www.medworm.com/index.php?rid=5664664&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02576.x Conclusions  Coherent with in vitro observation in transfected cells, our clinical observations demonstrate that the R137C–V2R mutant is resistant to vasopressin stimulation in its physiological sites of expression. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5664664 Tue, 07 Feb 2012 02:06:13 +0100 5664664 http://www.medworm.com/index.php?rid=5664663&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02574.x Conclusions  Visit‐to‐visit variability in blood pressure was significantly associated with all‐cause mortality independent of mean BP in patients with type 2 diabetes. The data for blood pressure variability might be regarded as a potentially important therapeutic target in the management of type 2 diabetes. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5664663 Tue, 07 Feb 2012 02:06:11 +0100 5664663 http://www.medworm.com/index.php?rid=5664662&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2012.02645.x (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5664662 Tue, 07 Feb 2012 02:06:08 +0100 5664662 http://www.medworm.com/index.php?rid=5664661&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2012.02655.x Conclusion:  The INa,L enhancer ATX‐II can increase PV arrhythmogenesis, which can be attenuated or blocked by ranolazine. This suggests that AF may be related to type 3 LQTS through increased INa,L. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5664661 Tue, 07 Feb 2012 02:06:06 +0100 5664661 http://www.medworm.com/index.php?rid=5627585&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2012.02654.x (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5627585 Thu, 26 Jan 2012 05:54:06 +0100 5627585 http://www.medworm.com/index.php?rid=5607500&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2012.02648.x Conclusions:  The present data confirm the relationship of Sst2 and Sst5 expression levels with reduced tumor aggressiveness. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5607500 Fri, 20 Jan 2012 08:00:05 +0100 5607500 http://www.medworm.com/index.php?rid=5581536&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2012.02646.x Conclusion:  Plasma sRAGE levels are lower in COPD patients compared to healthy control subjects, even lower levels in patients receiving LTOT. Since sRAGE correlated with lung function only in the whole group, sRAGE can be considered a marker of COPD, but not of disease severity. A lack of clear association between sRAGE, CML and systemic inflammation is furthermore evident. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5581536 Fri, 13 Jan 2012 17:01:29 +0100 5581536 http://www.medworm.com/index.php?rid=5569974&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02632.x (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5569974 Sat, 07 Jan 2012 11:48:38 +0100 5569974 http://www.medworm.com/index.php?rid=5569973&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02562.x Conclusions  The improvement in standard discrimination measures, which focus on finding variables that might be promising across all decision thresholds, may not detect the most informative markers at a specific threshold of particular clinical relevance. When a marker is intended to support decision‐making, calculation of the improvement in a decision‐analytic measure, such as NB, is preferable over an overall judgment as obtained from the AUC in ROC analysis. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5569973 Sat, 07 Jan 2012 11:48:35 +0100 5569973 http://www.medworm.com/index.php?rid=5569972&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02575.x Conclusions  The observation of central sensitisation in CFS is in line with our current understanding of CFS. The presence of central sensitisation in CFS corroborates with the presence of several psychological influences on the illness, the presence of infectious agents and immune dysfunctions and the dysfunctional hypothalamus–pituitary–adrenal axis as seen in these severely debilitated patients. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5569972 Sat, 07 Jan 2012 11:48:32 +0100 5569972 http://www.medworm.com/index.php?rid=5569971&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02560.x Conclusions  In NERD subjects, acid perfusion reliably evoked heartburn symptoms of greater intensity than in healthy controls. Nevertheless, a high PCO2 perfusion failed to produce symptoms in either group. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5569971 Sat, 07 Jan 2012 11:48:30 +0100 5569971 http://www.medworm.com/index.php?rid=5569970&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02567.x Conclusion  When exercising to comparable levels to normal controls, CFS patients exhibit profound abnormality in bioenergetic function and response to it. Although exercise intervention is the logical treatment for patients showing acidosis, any trial must exclude subjects who do not initiate exercise as they will not benefit. This potentially explains previous mixed results in CFS exercise trials. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5569970 Sat, 07 Jan 2012 11:48:27 +0100 5569970 http://www.medworm.com/index.php?rid=5569969&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02568.x Conclusions  High BMI status is suggested to attenuate the associations of alcohol intake with lower LDL cholesterol, higher HDL cholesterol and lower LDL/HDL ratio. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5569969 Sat, 07 Jan 2012 11:48:26 +0100 5569969 http://www.medworm.com/index.php?rid=5569968&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02570.x Conclusions  Polymorphisms of the UCP2 gene (rs660339 and rs659366) were associated with central obesity. This study shows association between the UCP2 gene and the susceptibility to obesity and body fat distribution in a south European population. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5569968 Sat, 07 Jan 2012 11:48:23 +0100 5569968 http://www.medworm.com/index.php?rid=5569967&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02572.x Conclusions  In hyperlipidaemic patients, the amount of visceral fat correlates with cholesterol synthesis; the use of ultrasonographic detection of abdominal adiposity allows a better characterization of cholesterol pathway, potentially useful for a tailored therapeutic approach. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5569967 Sat, 07 Jan 2012 11:48:21 +0100 5569967 http://www.medworm.com/index.php?rid=5569966&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02573.x Conclusions  Liver dysfunction is frequent in CHF and characterized by a predominantly cholestatic enzyme profile that is associated with disease severity and prognosis. Thus, we propose a cardio‐hepatic syndrome in CHF. Future studies are needed to clarify the exact mechanisms of organ interaction. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5569966 Sat, 07 Jan 2012 11:48:19 +0100 5569966 http://www.medworm.com/index.php?rid=5569965&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02571.x Conclusions  Elevated TE value at admission is associated with increased mortality, cirrhosis of the liver and CHF. This information may potentially be used to improve the outcome of high‐risk patients admitted to hospital. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5569965 Sat, 07 Jan 2012 11:48:17 +0100 5569965 http://www.medworm.com/index.php?rid=5569964&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02563.x Conclusions  Our data underline the superiority of UDCA‐LPE compared to UDCA‐PE in ameliorating acute liver inflammation. This indicates the significance of the lyso‐functional group of bile acid conjugate for optimal hepatoprotection and reduction in inflammation in vivo. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5569964 Sat, 07 Jan 2012 11:48:12 +0100 5569964 http://www.medworm.com/index.php?rid=5569962&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2012.02645.x (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5569962 Sat, 07 Jan 2012 11:48:05 +0100 5569962 http://www.medworm.com/index.php?rid=5569963&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2012.02640.x AbstractIschemic stroke is one of the major causes of death and lifelong disability also in the paediatric population. Strong scientific effort has been done to clarify the pathophysiology of this disease in adults. However, only few studies have been performed in children. Preliminary results indicate that pathophysiological processes might differently affect the post‐stroke neuronal injury in neonates as compared to children. During the neural development, selective molecular mechanisms might be differently triggered by an ischemic insult, thus potentially resulting in defined post‐ischemic clinical outcomes. Basic research studies in neonatal animal models of cerebral ischemia have recently shown a potential role of soluble inflammatory molecules (such as cytokines, chemokines and o... European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5569963 Wed, 04 Jan 2012 05:00:00 +0100 5569963 http://www.medworm.com/index.php?rid=5553489&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02644.x Conclusions:  Raised MCV in the presence of elevated red cell folate, adequate B12 status and low plasma urate, suggest potential methyltetrahydrofolate trapping and impaired purine synthesis. Well documented malnutrition issues in O may explain differences between CP groups. These data support the hypothesis of possible dysregulation in methylation capacity and/or folate one‐carbon metabolism, although more research is needed to elucidate a precise mechanism. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5553489 Sun, 01 Jan 2012 02:18:06 +0100 5553489 http://www.medworm.com/index.php?rid=5539959&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02639.x Conclusions:  Histones, ribosomal and heat shock proteins were mainly found in the case group and we confirm that almost 60% of these proteins were also found in a subset of the samples in our previous study using microarray on folate responsive gene expression. The proteins were compared to known biological pathways and matched with recent relevant literature. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5539959 Sun, 25 Dec 2011 20:36:05 +0100 5539959 http://www.medworm.com/index.php?rid=5518467&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02638.x Conclusion:  eNOS G894T gene polymorphism in homozygous TT carriers translates into opposing effects on erectile function (detrimental) and ocular hypertension/glaucoma (protective) in T2DM, without affecting glucose homeostasis determinants or the presence of micro‐ and macrovascular complications. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5518467 Mon, 19 Dec 2011 22:24:05 +0100 5518467 http://www.medworm.com/index.php?rid=5499680&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02634.x Conclusion:  LpPLA2 activity is predictive for cardiovascular outcome and total mortality. Reducing LpPLA2 by atorvastatin was associated with reduced mortality in patients with T2D on hemodialysis. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5499680 Wed, 14 Dec 2011 02:06:06 +0100 5499680 http://www.medworm.com/index.php?rid=5482221&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02555.x Conclusions  The available studies consistently showed that CAC scoring improves risk stratification in CVD risk categories when added to traditional risk factors only, especially among individuals at intermediate risk for CVD. Cost‐effectiveness analyses together with a randomized controlled trial are needed before widespread introduction of CAC in clinical care. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5482221 Thu, 08 Dec 2011 06:48:26 +0100 5482221 http://www.medworm.com/index.php?rid=5482220&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02550.x Conclusions  A number of patients presenting with hirsutism and exhibiting similar features to PCOS may have other underlying diagnoses. Unlike PCOS, some of these disorders can occasionally be life threatening and require prompt diagnosis and treatment. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5482220 Thu, 08 Dec 2011 06:48:23 +0100 5482220 http://www.medworm.com/index.php?rid=5482219&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02559.x Conclusions  Low levels of testosterone and SHBG increase the risk of T2D in men, and high levels of testosterone increase the risk of insulin resistance in women. The association between TT levels and the risk of T2D is not completely independent of other variables, such as exposure time, adiposity, insulin resistance or SHBG levels. This study also shows that the different responses between men and women are probably because of the protective effect of SHBG, levels of which are higher in women than in men. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5482219 Thu, 08 Dec 2011 06:48:21 +0100 5482219 http://www.medworm.com/index.php?rid=5482218&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02558.x Conclusions  Obesity and insulin resistance, more than type 2 diabetes, play the most relevant role in oxidative stress development. The correction of obesity and insulin resistance might be a useful strategy in counteracting systemic oxidative stress. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5482218 Thu, 08 Dec 2011 06:48:20 +0100 5482218 http://www.medworm.com/index.php?rid=5482217&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02557.x Conclusions  The expression of IL‐28, a T‐cell autocrine factor, is dysregulated in patients with SLE, supporting the possibility that IL‐28 may contribute to some of the SLE pathogenesis. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5482217 Thu, 08 Dec 2011 06:48:18 +0100 5482217 http://www.medworm.com/index.php?rid=5482216&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02556.x Conclusions  Our results indicate that PLCγ2 participates in bone resorption under basal conditions, likely because of its role in adhesion receptor signalling during osteoclast development. In contrast, PLCγ2 does not appear to play a major role in ovariectomy‐induced bone loss. These results suggest that basal and oestrogen deficiency–induced bone resorption utilizes different signalling pathways and that PLCγ2 may not be a suitable therapeutic target in postmenopausal osteoporosis. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5482216 Thu, 08 Dec 2011 06:48:17 +0100 5482216 http://www.medworm.com/index.php?rid=5482215&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02551.x Conclusion  Our findings demonstrate the high degree of endothelial activation and damage seen in sickle cell patients even in steady‐state condition, as well as the important chronic inflammation underlying the pathophysiology of this widespread disease. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5482215 Thu, 08 Dec 2011 06:48:12 +0100 5482215 http://www.medworm.com/index.php?rid=5482214&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02561.x Eur J Clin Invest 2012; 42 (1): 1–16Summary pointsAdvances in laboratory techniques have led to a rapidly increasing use of biomarkers in epidemiological studies. Biomarkers of internal dose, early biological change, susceptibility and clinical outcomes are used as proxies for investigating interactions between external and/or endogenous agents and body components or processes. The need for improved reporting of scientific research led to influential statements of recommendations such as the STrengthening Reporting of OBservational studies in Epidemiology (STROBE) statement. The STROBE initiative established in 2004 aimed to provide guidance on how to report observational research. Its guidelines provide a user‐friendly checklist of 22 items to be reported in epidemiological studies, w... European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5482214 Thu, 08 Dec 2011 06:48:09 +0100 5482214 http://www.medworm.com/index.php?rid=5482212&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02636.x Conclusion:  While LpB:E+LpB:C:E and LpB:C functioned as CE acceptors in both groups, these subclasses increased their CE content to a greater degree and accrued more CE per particle in the T1D subjects. Since this disturbance in lipoprotein remodeling may increase the cholesterol burden and potential atherogenicity of these apoB subclasses, it may be be a previously unrecognized factor that increases cardiovascular risk in T1D patients. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5482212 Thu, 08 Dec 2011 06:48:05 +0100 5482212 http://www.medworm.com/index.php?rid=5482213&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02635.x Conclusions:  ApoB48 concentrations are highest in patients with FCH and in atherosclerotic subjects with T2DM. In patients not using statins, the surrogate atherosclerosis marker IMT correlates best with apoB48 suggesting that fasting apoB48 may help to detect subjects at risk. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5482213 Fri, 02 Dec 2011 05:00:00 +0100 5482213 http://www.medworm.com/index.php?rid=5447951&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02633.x Conclusions:  Patients presenting multifocal, bilateral PTMC with a maximum diameter >5mm and thyroid capsule invasion may have an increased risk of lymph node metastasis. These factors should be considered in the follow‐up for these patients. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5447951 Sat, 26 Nov 2011 15:36:06 +0100 5447951 http://www.medworm.com/index.php?rid=5428904&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02624.x (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5428904 Sun, 20 Nov 2011 19:30:40 +0100 5428904 http://www.medworm.com/index.php?rid=5428903&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02542.x Eur J Clin Invest 2011; 41 (12): 1368 (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5428903 Sun, 20 Nov 2011 19:30:38 +0100 5428903 http://www.medworm.com/index.php?rid=5428902&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02545.x Conclusions  Several proinflammatory cytokines (such as TNFa, IL‐1 and IL‐17) are major triggers for osteoclast activation explaining the enhanced bone loss during inflammation. Other such as IL‐12, IL‐18, IL‐33 and IFN are strong suppressors of osteoclast differentiation and inhibit bone loss. Thus the cytokine composition of an inflammatory tissue is decisive whether inflammation triggers bone loss or not. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5428902 Sun, 20 Nov 2011 19:30:35 +0100 5428902 http://www.medworm.com/index.php?rid=5428901&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02537.x Eur J Clin Invest 2011; 41 (12): 1353–1360AbstractEndocrine tumours derived from the small intestine, ileal carcinoids, produce and secrete the hormones tachykinins and serotonin, which induces the specific symptoms related to the tumour. Because of their low proliferation rate, they are often discovered at late stages when metastases have occurred. The biology that characterizes these tumours differs in many ways from what is generally recognized for other malignancies. In this overview, the current knowledge on the development and progression of ileal carcinoids is described. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5428901 Sun, 20 Nov 2011 19:30:34 +0100 5428901 http://www.medworm.com/index.php?rid=5428900&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02534.x Conclusions  The more recent views that asthma is a complex disorder made up of different subtypes with differing causes, treatment responses and natural histories creates a new opportunity for stratified medicine in which therapies acting upstream selectively target specific disease subtypes identified by specific diagnostic biomarkers. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5428900 Sun, 20 Nov 2011 19:30:32 +0100 5428900 http://www.medworm.com/index.php?rid=5428899&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02548.x Conclusions  Although diabetes and genetic variants at the ADIPOQ gene influence the circulating levels of adiponectin in CHF, higher plasma adipokine levels, but not genetic variants, are consistently associated with a poor prognosis. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5428899 Sun, 20 Nov 2011 19:30:30 +0100 5428899 http://www.medworm.com/index.php?rid=5428898&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02547.x Conclusions  Using a highly selective pharmacological tool, we show here that the individual responsiveness of human muscle cell PPARδ, rather than the absolute PPARD expression level, represents a major determinant of insulin sensitivity. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5428898 Sun, 20 Nov 2011 19:30:29 +0100 5428898 http://www.medworm.com/index.php?rid=5428897&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02546.x Conclusions  These findings suggest that changes in free radical generation and consequent oxidative stress may have a role in the pathogenesis of acute ischaemic lesions. The activation of defence mechanisms like total antioxidant capacity could be involved in the limitation of ischaemic damage progression. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5428897 Sun, 20 Nov 2011 19:30:27 +0100 5428897 http://www.medworm.com/index.php?rid=5428896&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02544.x Conclusions  Depression symptoms predict long‐term mortality in elderly subjects without and, even more, with CHF. Thus, depression can be considered a strong predictor of death in CHF elderly subjects. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5428896 Sun, 20 Nov 2011 19:30:26 +0100 5428896 http://www.medworm.com/index.php?rid=5428895&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02540.x Conclusions  We found no difference in mean plasma vitamin D levels between patients with ACS and controls. Differences in population characteristics between the two study groups including medications use and the lack of data on vitamin D, calcium and multivitamin supplements intake as well as the relatively small sample size of the populations could confound the results. Ethnic background, sex, age, body weight and SNPs in CYP24A1 and PLCB1 were independent determinants of plasma vitamin D levels. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5428895 Sun, 20 Nov 2011 19:30:24 +0100 5428895 http://www.medworm.com/index.php?rid=5428894&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02539.x Conclusions  N‐terminal pro‐B‐type natriuretic peptide and HbA1c concentrations significantly diverged over a 1‐year period. NT‐proBNP was the most potent predictor of outcome at baseline and follow‐up, and changes in NT‐proBNP concentrations were linked to an altered risk profile, unlike changes in HbA1c levels. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5428894 Sun, 20 Nov 2011 19:30:22 +0100 5428894 http://www.medworm.com/index.php?rid=5428893&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02533.x Conclusions  Elderly patients represent a relevant collective of patients with ACS and are treated less optimally. ABI predicts 1‐year mortality after an ACS in elderly patients. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5428893 Sun, 20 Nov 2011 19:30:17 +0100 5428893 http://www.medworm.com/index.php?rid=5428887&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02631.x Conclusion:  The results of this study demonstrate the independent prognostic value of inorganic phosphate and FGF‐23 in heart failure even in the context of established risk markers. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5428887 Sun, 20 Nov 2011 19:30:07 +0100 5428887 http://www.medworm.com/index.php?rid=5428888&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02630.x Conclusions:  LA cotreatment could significantly prevent mild portal endotoxemia‐induced chronic hepatic inflammation and impaired pancreatic insulin secretion in absence of changing systemic insulin resistance. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5428888 Wed, 16 Nov 2011 05:00:00 +0100 5428888 http://www.medworm.com/index.php?rid=5428892&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02626.x Conclusions:  Assessment of resting pulmonary function and cardiopulmonary functional capacity could contribute to the evaluation of pulmonary impairment in PCD. Given the benefit of physical exercise on airway clearance and on general health and quality of life PCD patients should be encouraged to adopt an active lifestyle. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5428892 Thu, 10 Nov 2011 05:00:00 +0100 5428892 http://www.medworm.com/index.php?rid=5428891&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02627.x Conclusions:  Neck circumference measurement was shown to be associated with cardiometabolic risk factors in children. We suggest the use of neck circumference as a novel, simple, practical, and reliable anthropometric index in predicting children at risk for cardiometabolic diseases. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5428891 Thu, 10 Nov 2011 05:00:00 +0100 5428891 http://www.medworm.com/index.php?rid=5428890&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02628.x Conclusion:  Hypoxia in neonatal cardiomyocytes increases myocardin expression and ROS to cause cardiomyocyte hypertrophy, which can be prevented by atorvastatin by suppressing ROS and myocardin expression. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5428890 Thu, 10 Nov 2011 05:00:00 +0100 5428890 http://www.medworm.com/index.php?rid=5428889&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02629.x Conclusion:  Non‐HDL‐cholesterol is most strongly associated with premature CAD and could serve as preferred risk predictor and therapeutic target in this young patient population (≤40 years). Besides, VLDL, LDL‐C, large LDL, intermediate LDL and large IDL were significantly associated with premature myocardial infarction. Furthermore, our data suggest that risk prediction using small dense LDL particles might not be useful in young AMI survivors. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5428889 Thu, 10 Nov 2011 05:00:00 +0100 5428889 http://www.medworm.com/index.php?rid=5363955&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02625.x Conclusions:  Our results demonstrated that kaerophyllin protected the rat liver from TAA‐caused injury and fibrogenesis by suppressing hepatic inflammation and inhibiting HSC activation, possibly through upregulation of PPAR‐γ expression. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5363955 Tue, 01 Nov 2011 04:00:00 +0100 5363955 http://www.medworm.com/index.php?rid=5334270&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02622.x AbstractDue to growing rates of diabetes, hypertension and the aging population, the prevalence of end‐stage renal disease, developed from earlier stages of chronic kidney disease, and of acute renal failure is dramatically increasing. Dialysis and preferable renal transplantation are widely applied therapies for this incurable condition. However these options are limited because of morbidity, shortage of compatible organs and costs. Therefore, stem cell‐based approaches are becoming increasingly accepted as an alternative therapeutic strategy.Since their discovery in 2003, amniotic fluid stem (AFS) cells have been shown to be pluripotent with the potential to form embryoid bodies. Compared to adult stem cells, induced pluripotent stem cells or embryonic stem cells, AFS cells harbour a... European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5334270 Fri, 21 Oct 2011 11:55:05 +0100 5334270 http://www.medworm.com/index.php?rid=5319396&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02519.x Conclusions  Future research should critically appraise precisely what is being modelled by EAE before drawing conclusions about human disease. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5319396 Sun, 16 Oct 2011 02:20:37 +0100 5319396 http://www.medworm.com/index.php?rid=5319395&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02529.x Conclusions  No differences were found in the release kinetics of EPC, VEGF or HGF after a first infarction according to whether the patients had angina during the week before the infarction. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5319395 Sun, 16 Oct 2011 02:20:30 +0100 5319395 http://www.medworm.com/index.php?rid=5319394&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02525.x Conclusions  We observed stronger associations of serum 25OHD with insulin sensitivity in overweight than normal weight subjects, suggesting that overweight subjects with hypovitaminosis D may benefit more from vitamin D replacement than normal weight subjects. Furthermore, the optimal serum 25OHD concentration for insulin sensitivity is about 40 ng mL−1. As more than 60% of the US population is overweight and hypovitaminosis D is highly prevalent in overweight subjects, hypovitaminosis D has a large population attributable risk for type 2 diabetes. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5319394 Sun, 16 Oct 2011 02:20:25 +0100 5319394 http://www.medworm.com/index.php?rid=5319393&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02524.x Conclusions  Our results show that γδ cell function is impaired in patients with advanced melanoma and suggest a possible role in tumour progression. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5319393 Sun, 16 Oct 2011 02:20:24 +0100 5319393 http://www.medworm.com/index.php?rid=5319392&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02523.x Conclusions  We conclude that during the 20‐min supine post‐syncopal period, plasma volume, PRA and AVP return closer to baseline but aldosterone and ACTH continue increasing. The magnitude of observed concentration changes cannot be explained by haemoconcentration/haemodilution, rather it appears that the observed changes are indicative of hormone‐specific endocrine activation patterns in the recovery phase. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5319392 Sun, 16 Oct 2011 02:20:22 +0100 5319392 http://www.medworm.com/index.php?rid=5319391&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02522.x Conclusions  ARBs were associated with lower aortic valve weight and less pronounced tissue remodelling. Further studies are needed to determine if ARBs could be used as a therapeutic avenue in AS. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5319391 Sun, 16 Oct 2011 02:20:20 +0100 5319391 http://www.medworm.com/index.php?rid=5319390&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02514.x Conclusions  This study demonstrates that bone marrow‐derived RAGE is an important factor in the progression of atherosclerotic plaques. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5319390 Sun, 16 Oct 2011 02:20:18 +0100 5319390 http://www.medworm.com/index.php?rid=5319389&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02588.x Eur J Clin Invest 2011; 41 (11): 1149–1163 (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5319389 Sun, 16 Oct 2011 02:20:16 +0100 5319389 http://www.medworm.com/index.php?rid=5319384&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02619.x Conclusions:  OPG is an indicator of diabetes‐ and hypertension‐associated vascular pathologies as endothelial dysfunction and cardiovascular risk. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5319384 Sun, 16 Oct 2011 02:20:05 +0100 5319384 http://www.medworm.com/index.php?rid=5319385&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02618.x Conclusion:  Aβ25–35 has direct electrophysiological effects on PV cardiomyocytes. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5319385 Fri, 14 Oct 2011 04:00:00 +0100 5319385 http://www.medworm.com/index.php?rid=5319386&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02617.x (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5319386 Wed, 12 Oct 2011 04:00:00 +0100 5319386 http://www.medworm.com/index.php?rid=5319387&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02616.x Conclusions:  Our data suggested serum IGF‐1 was a contributing factor in severe diabetic retinopathy and this effect may be masked by poor glycemic control. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5319387 Tue, 11 Oct 2011 04:00:00 +0100 5319387 http://www.medworm.com/index.php?rid=5319388&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02615.x Conclusion:  Uninterpretable ECGs portend a worse prognosis in patients referred for stress testing. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5319388 Mon, 10 Oct 2011 04:00:00 +0100 5319388 http://www.medworm.com/index.php?rid=5302358&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02614.x Abstract:Fabry disease is a rare X‐linked lysosomal storage disorder leading to an accumulation of globotriaosylceramides in the lysosomes of various organs. Being X‐chromosomal linked, most studies in the past have focused on involvement in male patients. However, it has been elucidated recently that female patients can present typical organ involvement and thus, need to be treated, respectively. This review wants to give a systematical overview of the typical organ involvement in female Fabry patients. Moreover, therapy recommendations especially for female patients are discussed. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5302358 Mon, 10 Oct 2011 04:00:00 +0100 5302358 http://www.medworm.com/index.php?rid=5284634&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02612.x (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5284634 Tue, 04 Oct 2011 04:00:00 +0100 5284634 http://www.medworm.com/index.php?rid=5284635&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02611.x Conclusions: Chronic aliskiren use reduces portal pressure in portal hypertensive rats partly due to the modulation of splanchnic and collateral NO synthase. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5284635 Mon, 03 Oct 2011 04:00:00 +0100 5284635 http://www.medworm.com/index.php?rid=5284633&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02613.x Conclusions:  Low serum sodium concentration is associated with mortality only in those with diabetes. Furthermore, the impact of serum sodium on survival in these patients seems to be derived from poor glucose control. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5284633 Sat, 01 Oct 2011 04:00:00 +0100 5284633 http://www.medworm.com/index.php?rid=5268961&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02610.x (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5268961 Fri, 30 Sep 2011 19:30:05 +0100 5268961 http://www.medworm.com/index.php?rid=5249860&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02607.x Conclusions:  Endothelial damage/dysfunction is present early in the course of inflammatory arthritis, but is not directly related to inflammation markers. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5249860 Sun, 25 Sep 2011 04:32:06 +0100 5249860 http://www.medworm.com/index.php?rid=5222088&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02521.x Conclusions  This study supports previous findings of sex differences in adrenergic responsiveness and suggests that its consequences are systemically relevant. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5222088 Fri, 16 Sep 2011 07:00:33 +0100 5222088 http://www.medworm.com/index.php?rid=5222087&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02518.x Conclusions  In conclusion, regardless of a genetic background, the size of a primary pheochromocytoma and age of its first presentation are two independent risk factors associated with the development of metastatic disease. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5222087 Fri, 16 Sep 2011 07:00:32 +0100 5222087 http://www.medworm.com/index.php?rid=5222086&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02517.x Conclusions  These observations may explain in part the mechanism of cyclosporine‐induced hypertension, hyperkalemia and hypercalciuria. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5222086 Fri, 16 Sep 2011 07:00:30 +0100 5222086 http://www.medworm.com/index.php?rid=5222085&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02516.x Conclusions  These results suggest that 8q22–24; 11q23–25 and 16q23–24 regions are very likely to contain genes that control HDL‐C level in Iranian families with metabolic syndrome. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5222085 Fri, 16 Sep 2011 07:00:29 +0100 5222085 http://www.medworm.com/index.php?rid=5222084&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02515.x Conclusions  Our data suggest that the regulation of nampt in macrophages is linked to pro‐atherogenic stimuli, potentially mediating counteracting effects on lipid accumulation and foam cell formation. These findings suggest a rather complex role of nampt in atherogenesis, potentially mediating both adaptive and maladaptive responses. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5222084 Fri, 16 Sep 2011 07:00:27 +0100 5222084 http://www.medworm.com/index.php?rid=5222083&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02513.x Conclusions  Our results demonstrate that cholesterol‐lowering interventions exerted down regulatory effects on vascular LRP1 over expression induced by hypercholesterolemia and that simvastatin did not influence LRP1 expression beyond its cholesterol‐lowering effects. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5222083 Fri, 16 Sep 2011 07:00:26 +0100 5222083 http://www.medworm.com/index.php?rid=5222078&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02605.x Conclusion:  Carotid alterations consequent upon MetS ultimately developed subclinical and clinical atherosclerosis, the underlying risk factors for which were abdominal obesity, hypertension, aging and low level of HDL‐C. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5222078 Fri, 16 Sep 2011 07:00:06 +0100 5222078 http://www.medworm.com/index.php?rid=5222080&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02596.x Conclusions:  LVEF can be estimated using a novel acoustic based device. This device may assist in triage of patients according to LVEF prior to definitive assessment of LVEF by echocardiography. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5222080 Thu, 15 Sep 2011 04:00:00 +0100 5222080 http://www.medworm.com/index.php?rid=5222079&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02606.x Conclusions:  Our findings show that in severely obese patients following a VLCD for 6 weeks produces reductions of factor C3, a biomarker of cardiovascular disease, and a significant improvement in some features of metabolic syndrome. In this way, the abovementioned diet may represent an effective strategy for treating obesity and related cardiovascular risk factors. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5222079 Thu, 15 Sep 2011 04:00:00 +0100 5222079 http://www.medworm.com/index.php?rid=5222081&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02604.x Conclusions:  Overall anti‐oxidative functionality of HDL is impaired in type 2 diabetes mellitus mostly due to lower HDL cholesterol. Hyperglycemia, increased LCAT activity and lower PON‐1 activity likely contribute to impaired anti‐oxidative functionality of HDL. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5222081 Mon, 12 Sep 2011 04:00:00 +0100 5222081 http://www.medworm.com/index.php?rid=5222082&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02603.x Conclusions:  In conclusion, although the results need to be confirmed on a larger and homogeneus population, we hypothesized that the notion of using the measurement of ferritin and SOD in the EBC could, if deemed feasible, have clinical implications in the monitoring of lung cancer and as an outcome predictor. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5222082 Wed, 07 Sep 2011 04:00:00 +0100 5222082 http://www.medworm.com/index.php?rid=5196726&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02602.x AbstractAlbuminuria is an indicator of cardiovascular morbidity and mortality in patients with type 2 diabetic mellitus (T2DM). In our cross‐sectional study we measured thrombin generation (TG), a key process in haemostasis and a tool to detect an individual′s coagulation potential, in normo‐, micro‐, and macroalbuminuria in T2DM with and without macrovascular disease (MVD). The TG‐assay (Technothrombin, Vienna, Austria) was performed and the TG‐curve (including the lag phase, peak thrombin and area under the curve (AUC)) was analyzed.A total of 160 patients (62 women; mean age ±SD: 67±11 years) with T2DM and normo‐, micro‐ or macroalbuminuria were investigated. Of those 90 (56%) patients had normoalbuminuria, 40 (25%) microalbuminuria and 30 (19%) macroalbuminuria. The A... European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5196726 Thu, 01 Sep 2011 23:00:00 +0100 5196726 http://www.medworm.com/index.php?rid=5196725&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02593.x Conclusions:  Our study shows a relatively good prognosis of type 2 diabetic patients. Comorbidities, namely HF and renal impairment, are main determinants of survival. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5196725 Wed, 31 Aug 2011 23:00:00 +0100 5196725 http://www.medworm.com/index.php?rid=5180574&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02601.x Conclusions:  Hence, we suggest consideration of plasma myeloperoxidase for risk stratification of MACE in patients with PAD. In contrast, MPO‐463G>A is not an independent risk factor for MACE in patients suffering from PAD. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5180574 Wed, 31 Aug 2011 23:00:00 +0100 5180574 http://www.medworm.com/index.php?rid=5161830&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02600.x Conclusions:  The reduction of TMAMQ by serum samples is directly proportional to the consumption of oxygen and the formation of syringaldazine. This means that either the formation of syringaldazine or oxygen consumption can be used to validate or confirm data obtained through monitoring TMAMQ reduction. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5161830 Sat, 27 Aug 2011 14:48:04 +0100 5161830 http://www.medworm.com/index.php?rid=5144455&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02594.x Conclusions:  One‐month administration of 150 mg maintenance dose of clopidogrel reduces platelet reactivity and might decrease the risk of thrombo‐ischemic complications in stable angina patients with HPR identified by LTA. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5144455 Sat, 20 Aug 2011 16:08:05 +0100 5144455 http://www.medworm.com/index.php?rid=5119125&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02486.x Conclusions  LC3 gene expression in the peripheral leucocytes was significantly decreased in patients with CAD, indicating that autophagosome formation is decreased. These data suggest that autophagy in circulating leucocytes may be involved in the pathogenesis of atherosclerosis and CAD. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5119125 Fri, 12 Aug 2011 06:15:28 +0100 5119125 http://www.medworm.com/index.php?rid=5119120&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02591.x Conclusions:  Human erythrocytes carry apoB‐containing lipoproteins. Subjects with atherosclerosis have lower ery‐apoB. High ery‐apoB may be protective against atherosclerosis, and may reflect an alternative blood cell‐mediated lipoprotein transport system in the circulation, in which these lipoproteins less likely interact with the endothelium. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5119120 Fri, 12 Aug 2011 06:15:19 +0100 5119120 http://www.medworm.com/index.php?rid=5119121&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02585.x Conclusions:  These results suggested that chromosome 17 aneuploidy, but not topo IIα protein expression, could predict worse survival in DLBCL patients. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5119121 Wed, 10 Aug 2011 23:00:00 +0100 5119121 http://www.medworm.com/index.php?rid=5119122&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02586.x Conclusion:  Our results suggest that circulating visfatin levels correlate with WBC and CRP but are not associated with PCOS, obesity or metabolic markers, suggesting that visfatin may act as a proinflammatory cytokine. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5119122 Sun, 07 Aug 2011 23:00:00 +0100 5119122 http://www.medworm.com/index.php?rid=5119123&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02583.x Conclusion:  E‐selectin, an early atherosclerosis biomarker is positively associated with diastolic blood pressure values in children with T1DM, despite relatively short disease duration. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5119123 Thu, 04 Aug 2011 23:00:00 +0100 5119123 http://www.medworm.com/index.php?rid=5119124&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02584.x Conclusions:  Corticosteroids have been documented to decrease mortality in some indications, in particular, antenatal use for preterm labor, tuberculous meningitis, Pneumocystis pneumonia, and alcoholic hepatitis. Many postulated benefits of corticosteroids on mortality may reflect “vibration of treatment effects” leading to false‐positive claims from spurious subset analyses and even for standard indications, such biases may have inflated the treatment effect estimates. More large trials are needed for serious, common conditions where use of corticosteroids is proposed. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5119124 Wed, 03 Aug 2011 23:00:00 +0100 5119124 http://www.medworm.com/index.php?rid=5071193&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02582.x Conclusions:  The present lipid infusion protocol appears to be safe and well tolerated and provides significant incorporation of n‐3 PUFAs into plasma phospholipids and PBMCs. In the absence of overt inflammation, no direct effects of FO were observed on immune function or (anti)oxidant balance. This model may be useful to evaluate effects of parenteral lipids in other settings, for example in individuals displaying an inflammatory state. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5071193 Thu, 28 Jul 2011 21:45:22 +0100 5071193 http://www.medworm.com/index.php?rid=5024922&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02477.x (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5024922 Thu, 14 Jul 2011 06:45:49 +0100 5024922 http://www.medworm.com/index.php?rid=5024921&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02541.x Eur J Clin Invest 2011; 41 (8): 907–916AbstractDendritic cells (DC) play a key role in the initiation of adaptive immunity, and the manipulation and/or targeting of DC has great potential for immune intervention. However, clinical applications are hampered by the fact that we still know relatively little about how DC become ‘activated’ to stimulate and direct T‐cell responses. Over the last decade, much emphasis has been placed on dissecting innate signalling pathways that can trigger DC activation and promote T‐cell priming. Here, we review work from our laboratory aimed at helping define ‘pattern‐recognition pathways’ involved in DC activation by potential pathogens. One pathway for sensing infection by RNA viruses involves recognition of viral genomes or virally infected... European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5024921 Thu, 14 Jul 2011 06:45:47 +0100 5024921 http://www.medworm.com/index.php?rid=5024920&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02488.x Conclusions  Patients with PAH have lower bronchial NO flux compared to healthy controls and patients with PH WHO Group II–IV along with elevated salivary and plasma nitrite compared to controls. This implies reduced bronchial NO synthase‐derived NO formation in PAH. Increased alveolar NO levels were found in subjects with PH compared to controls, especially in subjects with PAH. This may reflect NO diffusion disturbances in the alveoli. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5024920 Thu, 14 Jul 2011 06:45:45 +0100 5024920 http://www.medworm.com/index.php?rid=5024919&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02480.x Conclusions  Immunotherapy with cockroach extract improved clinical and immunological status of asthma and rhinitis patients. Clinical improvement in patients after IT is associated with immunological changes. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5024919 Thu, 14 Jul 2011 06:45:44 +0100 5024919 http://www.medworm.com/index.php?rid=5024918&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02476.x Conclusions  We speculate that the observed differences in blood pressure and hormonal responses to LBNP and HUT are caused by divergent effects of blood pooling in the splanchnic region, despite similar reductions in splanchnic perfusion. Apparently with repeated central hypovolaemia, especially by the 3rd application of stress, plasma aldosterone levels rise (along with ACTH), conceivably increasing its volume‐guarding effect. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5024918 Thu, 14 Jul 2011 06:45:41 +0100 5024918 http://www.medworm.com/index.php?rid=5024917&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02475.x Conclusions  Our results demonstrate that CD36 expression is altered by hyperglycaemia in atherosclerotic patients. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5024917 Thu, 14 Jul 2011 06:45:40 +0100 5024917 http://www.medworm.com/index.php?rid=5024916&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02472.x Conclusions  In addition to PRA, renin rs11240688 CC polymorphism may also independently predict the effect of HCTZ. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5024916 Thu, 14 Jul 2011 06:45:37 +0100 5024916 http://www.medworm.com/index.php?rid=5024915&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02471.x Conclusions  Plasma Lp‐PLA2 may relate to early stages of atherosclerosis development. In diabetes mellitus, in contrast, the association of IMT with plasma Lp‐PLA2 mass is abolished, which could be partly ascribed to redistribution of Lp‐PLA2 mass from apolipoprotein B‐containing lipoproteins towards HDL. These findings raise questions about the usefulness of plasma Lp‐PLA2 mass measurement as a marker of subclinical atherosclerosis in type 2 diabetes mellitus. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5024915 Thu, 14 Jul 2011 06:45:36 +0100 5024915 http://www.medworm.com/index.php?rid=5024914&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2010.02466.x Conclusions  The feasibility of subject‐specific simulations of cardiovascular response to orthostatic stress was demonstrated, providing stronger evidence that capillary filtration is a prominent mechanism in causing orthostatic intolerance. These results may have clinical and spaceflight applications. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5024914 Thu, 14 Jul 2011 06:45:34 +0100 5024914 http://www.medworm.com/index.php?rid=5024906&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02578.x Conclusions.  Daily short‐term exposures to normobaric hyperoxia do not increase the [EPO] in healthy individuals. The increased O2 tension suppresses [EPO]. Hence, administration of pure O2 to enhance erythropoiesis is not warranted. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5024906 Thu, 14 Jul 2011 06:45:21 +0100 5024906 http://www.medworm.com/index.php?rid=5024908&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02579.x Conclusions Concomitant use of CCBs as a class did not modify the protective effect of clopidogrel and was not associated with increased cardiovascular risk among patients using clopidogrel after coronary stent implantation. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5024908 Tue, 12 Jul 2011 23:00:00 +0100 5024908 http://www.medworm.com/index.php?rid=5024907&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02580.x Conclusions:  This study provides evidence of an increased prevalence of anatomic and functional adrenal alterations in acromegalic patients; further studies will clarify the importance of evaluating these subjects with baseline hormonal investigation along with dynamic testing and modified cut‐offs. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5024907 Tue, 12 Jul 2011 23:00:00 +0100 5024907 http://www.medworm.com/index.php?rid=5024909&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02577.x (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5024909 Fri, 08 Jul 2011 23:00:00 +0100 5024909 http://www.medworm.com/index.php?rid=5024910&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02574.x Conclusions:  Visit‐to‐visit variability in blood pressure was significantly associated with all‐cause mortality independent of mean BP in patients with type 2 diabetes. The data for blood pressure variability might be regarded as a potentially important therapeutic target in management of type 2 diabetes. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5024910 Wed, 06 Jul 2011 23:00:00 +0100 5024910 http://www.medworm.com/index.php?rid=5024911&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02576.x Conclusions :  Coherent with in vitro observation in transfected cells, our clinical observations demonstrate that the R137C‐V2R mutant is resistant to vasopressin stimulation in its physiological sites of expression. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5024911 Mon, 04 Jul 2011 23:00:00 +0100 5024911 http://www.medworm.com/index.php?rid=5024913&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02554.x Conclusions  This study indicates a significant age‐related decrease in antioxidant enzyme activities accompanied by significantly increased systemic oxidative stress, which promotes the cardiovascular risk factors oxLDL, ADMA and fetuin A in elderly people. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5024913 Sun, 03 Jul 2011 23:00:00 +0100 5024913 http://www.medworm.com/index.php?rid=5024912&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02575.x AbstractCentral sensitization entails several top‐down and bottom‐up mechanisms, all contributing to the hyperresponsiveness of the central nervous system to a variety of inputs. In the late nineties, it was first hypothesized that chronic fatigue syndrome (CFS) is characterized by hypersensitivity of the central nervous system (i.e. central sensitization). Since then, several studies have examined central sensitization in patients with CFS. The present paper provides an overview of such studies. Various studies showed generalized hyperalgesia in CFS for a variety of sensory stimuli, including electrical stimulation, mechanical pressure, heat and histamine. Various tissues are affected by generalized hyperalgesia: the skin, muscle tissue, and the lungs. Generalized hyperalgesia in CFS ... European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=5024912 Thu, 30 Jun 2011 23:00:00 +0100 5024912 http://www.medworm.com/index.php?rid=4975971&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02571.x Conclusions:  Elevated TE value at admission is associated with increased mortality, cirrhosis of the liver and congestive heart failure. This information may potentially be used to improve the outcome of high risk patients admitted to hospital. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=4975971 Tue, 28 Jun 2011 23:30:09 +0100 4975971 http://www.medworm.com/index.php?rid=4925937&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02489.x Conclusions  All three trefoil peptides are expressed in foetal tissues but not in placenta or foetal membranes. Cord blood contains high levels of all three peptides, although for TFF2 and TFF3 at considerably lower levels than observed in the mother. Thus, the elevated serum levels of TFF2 and TFF3 in the pregnant women were most likely not of foetal origin. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=4925937 Tue, 14 Jun 2011 16:00:41 +0100 4925937 http://www.medworm.com/index.php?rid=4925936&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2010.02467.x Conclusions  The decrease in mean UBT values already occurs during the first decade of life, and results increase following the sixth decade. Females have significantly higher results than males even in early childhood and throughout old age. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=4925936 Tue, 14 Jun 2011 16:00:34 +0100 4925936 http://www.medworm.com/index.php?rid=4925935&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2010.02465.x Conclusions  Serum 8‐OHdG levels provide important prognostic information for the risk stratification of patients with heart failure. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=4925935 Tue, 14 Jun 2011 16:00:31 +0100 4925935 http://www.medworm.com/index.php?rid=4925934&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2010.02464.x Conclusions  Our results indicate that the elevated levels of tHcy in Japanese nondementia patients with type 2 diabetes are characterised by hippocampal atrophy and insulin resistance and that the Z‐score and HOMA index may be the primary factors that influence tHcy levels. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=4925934 Tue, 14 Jun 2011 16:00:28 +0100 4925934 http://www.medworm.com/index.php?rid=4925933&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2010.02462.x Conclusions  Serum potassium level is significantly associated with LVMI in PA patients. Compared with essential hypertensive patients, PA patients had a greater impairment of cardiac diastolic function. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=4925933 Tue, 14 Jun 2011 16:00:27 +0100 4925933 http://www.medworm.com/index.php?rid=4925932&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2010.02461.x Conclusions  Increased AChE and decreased LOOHs, which were influenced by increased PON1, were considered as indicators of efforts towards the protection of dopaminergic activity in central nervous system in RLS group. Increased ESR, MPV and low HRVi indicate elevated sympathetic activity in RLS group. Elevated sympathetic activity might be beneficial in relieving RLS symptoms, also causing increases in TOS. The evidence we found regarding oxidative stress and autonomic nervous system might be seminal in RLS treatment. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=4925932 Tue, 14 Jun 2011 16:00:25 +0100 4925932 http://www.medworm.com/index.php?rid=4925931&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2010.02460.x Conclusions  ACEIs/ARBs are effective for primary prevention and secondary prevention of AF. They decrease the incidence of AF especially in patients with hypertension, patients with chronic heart failure and those with AF. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=4925931 Tue, 14 Jun 2011 16:00:23 +0100 4925931 http://www.medworm.com/index.php?rid=4925930&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2010.02452.x Conclusions  A continuous block‐replacement regimen results in a stable thyroid function during 131I therapy but is hampered by the higher amounts of radioactivity required. The study demonstrates that the outcome in GD is highly unpredictable, while treatment failure in patients with TNG is correlated with a number of factors. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=4925930 Tue, 14 Jun 2011 16:00:19 +0100 4925930 http://www.medworm.com/index.php?rid=4925919&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02569.x (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=4925919 Tue, 14 Jun 2011 16:00:06 +0100 4925919 http://www.medworm.com/index.php?rid=4925921&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02567.x Conclusion:  When exercising to comparable levels to normal controls CFS patients exhibit profound abnormality in bioenergetic function and response to it. Although exercise intervention is the logical treatment for patients showing acidosis any trial must exclude subjects who do not initiate exercise as they will not benefit. This potentially explains previous mixed results in CFS exercise trials. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=4925921 Thu, 09 Jun 2011 23:00:00 +0100 4925921 http://www.medworm.com/index.php?rid=4925920&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02568.x Conclusions:  High BMI status is suggested to attenuate the associations of alcohol intake with lower LDL cholesterol, higher HDL cholesterol and lower LDL/HDL ratio. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=4925920 Thu, 09 Jun 2011 23:00:00 +0100 4925920 http://www.medworm.com/index.php?rid=4925922&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02566.x Conclusions  Pravastatin ameliorates hepatic encephalopathy and liver biochemistry and improves survival in rats with acute liver failure, but not in those with cirrhosis. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=4925922 Mon, 06 Jun 2011 23:00:00 +0100 4925922 http://www.medworm.com/index.php?rid=4925925&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02564.x Conclusions:  The PA‐TDI interval was significantly longer in patients with LV diastolic dysfunction than those without it. Its prolongation may reflect the severity of atrial remodeling due to the abnormal diastolic function of LV. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=4925925 Wed, 01 Jun 2011 23:00:00 +0100 4925925 http://www.medworm.com/index.php?rid=4925924&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02565.x Conclusions:  Circulating active TF and FXIa occur frequently in acute cerebrovascular ischemic events. Active FXIa in plasma might be useful as a novel risk marker of worse functional outcomes in patients with acute cerebrovascular events. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=4925924 Wed, 01 Jun 2011 23:00:00 +0100 4925924 http://www.medworm.com/index.php?rid=4925923&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02563.x Conclusion:  Our data underline the superiority of UDCA‐LPE compared to UDCA‐PE in ameliorating acute liver inflammation. This indicates the significance of the lyso‐functional group of bile acid conjugate for optimal hepatoprotection and reduction of inflammation in vivo. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=4925923 Wed, 01 Jun 2011 23:00:00 +0100 4925923 http://www.medworm.com/index.php?rid=4925929&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02549.x Conclusions  Hypoxia‐induced urotensin II expression in cardiac fibroblast is mediated by angiotensin II and through ROS and JNK pathway. Urotensin II is a mediator of angiotensin II‐induced cardiac fibrosis under hypoxia. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=4925929 Tue, 31 May 2011 23:00:00 +0100 4925929 http://www.medworm.com/index.php?rid=4925927&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02553.x Conclusions  Elevated levels of sE‐selectin and, to a smaller degree, sVCAM‐1 and oxLDL/LDL are associated with lower postischemic reactivity in the small distal arteries. sE‐selectin is the main determinant biomarker of saRHI as assessed by regression analysis. The presence of multiple risk factors weakens this association. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=4925927 Tue, 31 May 2011 23:00:00 +0100 4925927 http://www.medworm.com/index.php?rid=4925926&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02552.x Conclusions  The discovery of inherited deregulations in the IL‐10 signalling cascade is not only considered the missing link between IL‐10 and intestinal homeostasis, but also demonstrates how findings made in animal models help explaining human disease. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=4925926 Tue, 31 May 2011 23:00:00 +0100 4925926 http://www.medworm.com/index.php?rid=4878951&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02558.x CONCLUSIONS:  Obesity and insulin‐resistance, more than type 2 diabetes, play the most relevant role in oxidative stress development. The correction of obesity and insulin‐resistance might be a useful strategy in counteracting systemic oxidative stress. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=4878951 Tue, 31 May 2011 11:15:26 +0100 4878951 http://www.medworm.com/index.php?rid=4828112&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2010.02454.x Conclusions  Future studies need to target the issue of hidden heritability and to detect the causal gene variants within the identified gene loci. Improved understanding of the genetic contribution to type 2 diabetes may then help addressing the questions whether genotyping is useful to predict individual diabetes risk, identifies individual responsiveness to preventive and therapeutic interventions or at least allows for breaking down type 2 diabetes into smaller, clinically meaningful subtypes. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=4828112 Tue, 17 May 2011 09:35:33 +0100 4828112 http://www.medworm.com/index.php?rid=4828092&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2010.02459.x Conclusions  Our data suggest the involvement of caveolin‐1 in the case of abnormal lipogenesis and mitochondrial function typical of steatotic hepatocytes in NAFLD. Addressing the role played by caveolin‐1 in liver membranes in NAFLD may help future therapeutic choices in a frequent metabolic liver disease. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=4828092 Tue, 17 May 2011 09:34:01 +0100 4828092 http://www.medworm.com/index.php?rid=4828091&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2010.02451.x Conclusions  Plasma ADMA concentration decreases rapidly and transiently during the first 48 h of acute inflammation. This appears not be caused by increased catabolism and may reflect increased cellular partitioning. This may serve to regulate NOS activity and prevent harmful increases in inducible NOS in situations where it is not appropriate. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=4828091 Tue, 17 May 2011 09:33:46 +0100 4828091 http://www.medworm.com/index.php?rid=4828073&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2010.02450.x Conclusions  The subjective perception of dyspnoea in patients with hypertensive pulmonary oedema was not influenced by the application of a loop‐diuretic. Therefore, additional furosemide therapy needs to be scrutinized in the therapy of these patients. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=4828073 Tue, 17 May 2011 09:33:29 +0100 4828073 http://www.medworm.com/index.php?rid=4828070&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2010.02449.x Conclusions  Chronic exposure to cigarette smoke sustains the activation of the endothelial‐coagulative system and abstinence may result in the improvement of several endothelial‐coagulative abnormalities in regular smokers. This may translate into an overall decline in cardiovascular risk. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=4828070 Tue, 17 May 2011 09:33:13 +0100 4828070 http://www.medworm.com/index.php?rid=4827939&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02538.x Conclusions  Central obesity combined with HI/IR contributes to visfatin elevation. Visfatin association with metabolic/biochemical variables is gender dependent. Diet + enhanced physical activity are effective in visfatin reduction, the degree of which depends on baseline visfatin. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=4827939 Tue, 17 May 2011 09:15:35 +0100 4827939 http://www.medworm.com/index.php?rid=4827987&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02536.x Conclusions  Obese and overweight prepubertal children demonstrated prominent alterations in the expression of plasma apolipoproteins compared with their normal counterparts. Low ApoA‐I plasma expression levels and serum concentrations in obesity might be present in childhood before any significant alterations in total or high‐density lipoprotein‐cholesterol concentrations are documented. We recommend that serum ApoA‐I concentrations are determined in all overweight and obese children. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=4827987 Sun, 15 May 2011 23:00:00 +0100 4827987 http://www.medworm.com/index.php?rid=4827989&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02543.x Eur J Clin Invest 2011 (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=4827989 Sun, 08 May 2011 23:00:00 +0100 4827989 http://www.medworm.com/index.php?rid=4827991&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02532.x Conclusions  Hyponatremia and plasma concentrations of sodium are associated with long‐term mortality risk in patients with MI complicated by left ventricular systolic dysfunction. Importantly, these associations are independent of renal function and use of diuretics. Whether the associations between plasma sodium or hyponatremia and long‐term mortality risk reflect a causation or merely the severity of the underlying cardiac disease remains to be clarified. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=4827991 Thu, 05 May 2011 23:00:00 +0100 4827991 http://www.medworm.com/index.php?rid=4827993&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2011.02530.x Conclusions  The phagocyte activation marker MRP8/14 is significantly associated with markers of systemic inflammation in male patients with CAD. However, we were unable to find a correlation between circulating MRP8/14 complex and stable CAD. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=4827993 Tue, 03 May 2011 23:00:00 +0100 4827993