MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'European Journal of Clinical Investigation' source. Tue, 16 Mar 2010 15:37:58 +0100 http://www.medworm.com/index.php?rid=3332135&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2010.02267.x Conclusions These data demonstrate that 18 weeks of STZ treatment lead to a decrease in gastrocnemius mitochondrial respiratory control ratio and to decreased calcium-dependent mitochondrial MPTP. Results from this and other works suggest that mitochondrial effects of hyperglycaemia are time and organ specific. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=3332135 Fri, 05 Mar 2010 00:00:00 +0100 3332135 http://www.medworm.com/index.php?rid=3332137&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2010.02264.x Conclusions Aliskiren protected against chlorhexidine digluconate-induced PF in rats by decreasing TGF-[beta]1 production. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=3332137 Thu, 04 Mar 2010 00:00:00 +0100 3332137 http://www.medworm.com/index.php?rid=3332136&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2010.02268.x Conclusions The clinical phenotype of 'HCM' results from mutations in sarcomeric proteins and subsequent activation of multiple cellular constituents including signal transducers. We advocate that HCM, despite its current recognition and management as a single disease entity, involves multiple partially independent mechanisms, despite similarity in the ensuing phenotype. To treat HCM effectively, it is necessary to delineate the underlying fundamental mechanisms that govern the pathogenesis of the phenotype and apply these principles to the treatment of each subset of clinically recognized HCM. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=3332136 Thu, 04 Mar 2010 00:00:00 +0100 3332136 http://www.medworm.com/index.php?rid=3288771&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2010.02263.x Eur J Clin Invest 2010 Neurologic disorders are among the most comum and important clinical manifestations associated with the antiphospholipid syndrome (APS). It is characterized by diverse neurological manifestations. These include stroke, transient ischaemic attack, Sneddon's syndrome, convulsions/epilepsy, dementia, cognitive deficits, headaches/migraine, chorea, multiple sclerosis-like, transverse myelitis, ocular symptoms and Guillain-Barré syndrome. Our study group recently reported a correlation between primary APS and peripheral neuropathy. Only one study investigated the occurrence of peripheral neuropathy in patients diagnosed with PAPS through electrophysiological study and showed alterations in 35% of patients. The mechanism of nervous system involvement in APS is considered ... European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=3288771 Sat, 20 Feb 2010 00:00:00 +0100 3288771 http://www.medworm.com/index.php?rid=3288773&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2010.02259.x Conclusion High initial values of PCT and high peak levels after 3[ndash]4 days of CRP were found in patients with induction of hypothermia after cardiac arrest. This increase was unspecific and mirrors rather an inflammatory reaction than true underlying infection, limiting the diagnostic potential for early antibiotic stewardship in these patients. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=3288773 Fri, 19 Feb 2010 00:00:00 +0100 3288773 http://www.medworm.com/index.php?rid=3288772&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2010.02257.x Conclusion OPN may provide significant prognostic information independent of other traditional prognostic markers in patients with stable IHD. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=3288772 Fri, 19 Feb 2010 00:00:00 +0100 3288772 http://www.medworm.com/index.php?rid=3209026&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2010.02255.x Conclusions We hypothesize that weight-loss induced reduction in circulating chemerin might in conjunction with other factors be associated with diminished recruitment of macrophages in adipose tissue and reduction of subclinical inflammation, which again could partly explain beneficial long-term effects of weight reduction in obese subjects. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=3209026 Tue, 26 Jan 2010 00:00:00 +0100 3209026 http://www.medworm.com/index.php?rid=3198369&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02252.x Conclusions This study emphasizes the need to undertake systematic investigations while screening for the [beta] haemoglobinopathies to identify rare [alpha] chain variants in a population. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=3198369 Fri, 22 Jan 2010 00:00:00 +0100 3198369 http://www.medworm.com/index.php?rid=3198368&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02253.x Conclusion Thrombectomy in STEMI may decrease the long-term risk for death or cardiac re-hospitalization. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=3198368 Fri, 22 Jan 2010 00:00:00 +0100 3198368 http://www.medworm.com/index.php?rid=3198367&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02250.x Conclusion Short time HRT suppressed HMW and total adiponectin levels in TS patients. Testosterone treatment in KS patients had no effect on these parameters. In both groups of patients either adiponectin or the HMW subform seems to play no greater role in reflecting or mediating insulin sensitivity. Our data indicates that in patients with TS and KS, sex hormones have different effects on circulating adiponectin and its HMW subform than previously reported in other sex hormone deficient patients and healthy subjects. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=3198367 Fri, 22 Jan 2010 00:00:00 +0100 3198367 http://www.medworm.com/index.php?rid=3182644&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02251.x Conclusions Overexpression of the human endothelin-2 gene in rats aggravates diabetic cardiomyopathy by more severe coronary and intramyocardial vessel hypertrophy and myocardial interstitial fibrosis. This transgenic intervention provides further and independent support for a detrimental, blood pressure-independent role of endothelins in diabetic cardiac changes. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=3182644 Tue, 19 Jan 2010 00:00:00 +0100 3182644 http://www.medworm.com/index.php?rid=3156919&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02249.x Conclusions Addition of ezetimibe to fluvastatin resulted in a further reduction of buoyant and intermediate, but not of dense LDL compared with fluvastatin alone. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=3156919 Sun, 10 Jan 2010 00:00:00 +0100 3156919 http://www.medworm.com/index.php?rid=3134022&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02248.x Conclusions The prevalence of metabolic syndrome increases with elevated DHEA-S levels among elderly Taiwanese men. Thus, elevated serum DHEA-S level should be treated as an important risk factor for metabolic syndrome in elderly men. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=3134022 Thu, 31 Dec 2009 00:00:00 +0100 3134022 http://www.medworm.com/index.php?rid=3127110&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02240.x Conclusions Each company generates a clinical research agenda that is strongly focused on its own products, while comparisons involving different interventions from different companies are uncommon. This diminishes the ability to understand the relative merits of different interventions for the same condition. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=3127110 Tue, 29 Dec 2009 00:00:00 +0100 3127110 http://www.medworm.com/index.php?rid=3127112&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02238.x Conclusion These results provide evidence for linkage among body iron stores, transaminase activity and the prevalence of cardiometabolic risk factors in apparently healthy, non-obese adolescents even within the range of normal laboratory and anthropomorphic values and suggest that iron stores should be investigated as a potentially modifiable risk factor in healthy teenagers. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=3127112 Sun, 27 Dec 2009 00:00:00 +0100 3127112 http://www.medworm.com/index.php?rid=3127111&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02236.x Conclusions Intravenous ALA treatment improves endothelium-dependent vasodilatation in patients with type 2 diabetes, in the absence of effects on forearm vasomotor function. If this salutary action translates into vascular risk reduction remains to be established. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=3127111 Sun, 27 Dec 2009 00:00:00 +0100 3127111 http://www.medworm.com/index.php?rid=3110694&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02239.x Conclusions Our findings suggest that COX2 activation is crucially involved in the development of inflammatory response in adipose tissues of high-fat-induced obese rats. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=3110694 Tue, 22 Dec 2009 00:00:00 +0100 3110694 http://www.medworm.com/index.php?rid=3110697&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02231.x Conclusion We found in lean subjects, a robust lower level of cannabinoid receptor 1 in visceral adipose tissue compared with subcutaneous adipose tissue (both RNA and protein levels), but similar levels of cannabinoid receptor 1 between the two depots in obese subjects. Our present findings do not indicate that cannabinoid receptor 1 is directly involved in the endocannabinoid system over-activity in adipose tissue in obesity. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=3110697 Mon, 21 Dec 2009 00:00:00 +0100 3110697 http://www.medworm.com/index.php?rid=3110696&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02235.x Conclusions Pim-3 gene could protect rats from FHF by inhibiting liver apoptosis and improving inflammatory response of liver tissues, which could be associated with inhibiting expression of inflammatory mediators and promoting expression of anti-apoptosis protein Bcl-2. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=3110696 Mon, 21 Dec 2009 00:00:00 +0100 3110696 http://www.medworm.com/index.php?rid=3110695&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02237.x Conclusion The combination of HD tirofiban with enoxaparin resulted in an attenuated inflammatory response when compared with that of the combination of HD tirofiban with UFH. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=3110695 Mon, 21 Dec 2009 00:00:00 +0100 3110695 http://www.medworm.com/index.php?rid=3082681&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02218.x Conclusion Familial hypercholesterolaemia patients show increased activities of NF-kB and XO, and higher values of low grade inflammatory markers related to atherosclerosis. NF-kB activity was independently associated with apoB plasma values. These data could explain in part the high cardiovascular disease risk present in these patients. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=3082681 Sun, 13 Dec 2009 00:00:00 +0100 3082681 http://www.medworm.com/index.php?rid=3030175&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02224.x Conclusions Abnormal collagen V fibres are overproduced in lungs from SSc patients and may play an important role in the pathogenesis of the disease as this molecule regulates tissue collagen assembly. The aberrant histoarchitecture observed in SSc can be related to the overexpression of the [[alpha]2(V)] gene of unknown origin. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=3030175 Thu, 26 Nov 2009 00:00:00 +0100 3030175 http://www.medworm.com/index.php?rid=3030176&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02228.x Conclusions This is the first report showing that elevated IL-18 levels are associated with reduced LDL size, independent of other inflammatory and metabolic risk factors. Future prospective studies are needed to evaluate the predictive role of IL-18 as an inflammatory marker of LDL size and the development of subclinical and/or clinical atherosclerosis. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=3030176 Tue, 24 Nov 2009 00:00:00 +0100 3030176 http://www.medworm.com/index.php?rid=2989557&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02225.x Conclusions A placebo-controlled study of HOT in CFS is feasible. HOT is well tolerated and generally complied with. A likely physiological rationale for HOT in CFS is related to reductions in orthostatic intolerance. An adequately powered study including strategies to enhance compliance is warranted. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2989557 Fri, 13 Nov 2009 00:00:00 +0100 2989557 http://www.medworm.com/index.php?rid=2989560&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02221.x Conclusion Acute smoking has more deleterious effects in well-controlled properly treated asthmatic smokers compared with matched normal smokers. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2989560 Thu, 12 Nov 2009 00:00:00 +0100 2989560 http://www.medworm.com/index.php?rid=2989559&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02222.x (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2989559 Thu, 12 Nov 2009 00:00:00 +0100 2989559 http://www.medworm.com/index.php?rid=2989558&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02223.x Conclusions These results demonstrate that 15-LOX-2 is highly expressed in human plaques and is correlated with the presence of macrophages and HIF-1[alpha]. 15-LOX-2 enzyme activity can be modulated by HIF-1[alpha]. Thus, increased expression of 15-LOX-2 in macrophages in hypoxic atherosclerotic plaque may enhance inflammation and the recruitment of inflammatory cells. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2989558 Thu, 12 Nov 2009 00:00:00 +0100 2989558 http://www.medworm.com/index.php?rid=2981646&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02220.x Conclusions Different urinary biomarkers may reflect distinct pathophysiological mechanisms of tubulointerstitial damage in early diabetic nephropathy: Urinary L-FABP could be a novel biomarker for chronic intrarenal ischaemia. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2981646 Wed, 11 Nov 2009 00:00:00 +0100 2981646 http://www.medworm.com/index.php?rid=2939956&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02219.x Conclusions These data are consistent with previous studies on blood samples and suggest that non-invasive saliva samples may offer a practical approach to assessing pituitary-adrenal function continuously during and after short-term corticosteroid therapy. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2939956 Thu, 29 Oct 2009 00:00:00 +0100 2939956 http://www.medworm.com/index.php?rid=2914064&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02205.x Eur J Clin Invest 2009 Arterial lumen narrowing and vascular occlusion is the actual cause of morbidity and mortality in atherosclerotic disease. Collateral artery formation (arteriogenesis) refers to an active remodelling of non-functional vascular anastomoses to functional collateral arteries, capable to bypass the site of obstruction and preserve the tissue that is jeopardized by ischaemia. Hemodynamic forces such as shear stress and wall stress play a pivotal role in collateral artery formation, accompanied by the expression of various cytokines and invasion of circulating leucocytes. Arteriogenesis hence represents an important compensatory mechanism for atherosclerotic vessel occlusion. As arteriogenesis mostly occurs when lumen narrowing by atherosclerotic plaques takes place, prese... European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2914064 Wed, 21 Oct 2009 23:00:00 +0100 2914064 http://www.medworm.com/index.php?rid=2899592&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02217.x Conclusion Our data stress the importance of professional monitoring and titration of pharmacotherapy not only in medically treated CHF patients but also in patients under device therapy by a heart failure unit or a specialized cardiologist. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2899592 Thu, 15 Oct 2009 23:00:00 +0100 2899592 http://www.medworm.com/index.php?rid=2899593&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02216.x Conclusions Our study indicates that anti-complement mediators (C1-inh and clusterin) are deposited in diseased aortic valves together with activated complement, indicating an existing counter response against complement locally in the valve. However, deposition of activated complement is significantly more widespread than that of its inhibitors, which could explain ongoing inflammation in those diseased aortic valves. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2899593 Wed, 14 Oct 2009 23:00:00 +0100 2899593 http://www.medworm.com/index.php?rid=2867199&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02200.x Conclusions This study demonstrates that 15dPGJ2 is a potent modulator of the balance between MMP activities and TIMP levels, which is needed in the correct formation and function of the placenta and foetal organs. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2867199 Tue, 06 Oct 2009 23:00:00 +0100 2867199 http://www.medworm.com/index.php?rid=2867198&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02212.x Eur J Clin Invest 2009Background Advanced glycation endproducts (AGEs), particularly carboxymethyl(lysine)-adducts (CML), exert part of their cellular effects by binding to a receptor, named receptor for AGEs (RAGE). The soluble form of this receptor (sRAGE) has been shown to have an athero-protective role. We hypothesized the existence of a relationship between the AGE[ndash]RAGE axis and the occurrence of symptoms related to carotid atherosclerosis in nondiabetic conditions.Materials and methods We evaluated plasma levels of CML and sRAGE (by ELISA), and tissue levels (tAGEs and tRAGE, semiquantitatively, by immunohistochemistry) in endarterectomy carotid plaque tissue in 29 nondiabetic patients. At the time of surgery, 10 patients were asymptomatic and 19 were symptomatic.Results Plasma... European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2867198 Tue, 06 Oct 2009 23:00:00 +0100 2867198 http://www.medworm.com/index.php?rid=2867204&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02208.x Conclusions Ankle-brachial index, grade of symptoms and daily walking capacity could be used to predict collateral density. Importantly, a good antegrade flow and peripheral runoff seem to have a significant effect on collateral density, implying an impact on the activation of arteriogenesis. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2867204 Mon, 05 Oct 2009 23:00:00 +0100 2867204 http://www.medworm.com/index.php?rid=2867203&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02211.x Conclusion Adjustment of waist circumference for its determinants permits the detection of early impairment of cardiovascular function and of glucose and lipid metabolism in a clinically healthy population, in particular in normal body weight subjects. Enlarged hip adjusted values are associated with greater insulin sensitivity. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2867203 Mon, 05 Oct 2009 23:00:00 +0100 2867203 http://www.medworm.com/index.php?rid=2867202&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02214.x Conclusions We report that hypothyroid patients exhibit a moderate increase in the level of spontaneous genome damage, and that AI thyroid patients resulted to be less sensitive than NAI patients to the mutagen sensitivity test. In prospective, it may be of interest to reinvestigate hypothyroid patients when correction of their dysfunction is achieved. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2867202 Mon, 05 Oct 2009 23:00:00 +0100 2867202 http://www.medworm.com/index.php?rid=2867201&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02201.x Conclusions Age is an important predictor of endonasal perfusion. Evaluation of optical rhinometry needs to take age-dependency of results into account. Studies in patients with cardiovascular disease are needed to show if optical rhinometry can provide information about vascular responsiveness as a predictor of cardiovascular morbidity. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2867201 Mon, 05 Oct 2009 23:00:00 +0100 2867201 http://www.medworm.com/index.php?rid=2867200&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02210.x Conclusions The pro-inflammatory capacity of influenza NS1 deletion vaccine viruses could serve as an adjuvant-like agent to improve preparations of MODC-based anti-cancer vaccines. The complete NS1 deletion virus appears to be more potent as adjuvant when used for production of tumour lysates. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2867200 Mon, 05 Oct 2009 23:00:00 +0100 2867200 http://www.medworm.com/index.php?rid=2786354&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02206.x Conclusion Dasatinib acts not only anti-neoplastic in CML but may also act as an immunosuppressive agent when applied at 140 mg daily, and produces frequent pleural effusions and weight loss in advanced CML. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2786354 Tue, 08 Sep 2009 23:00:00 +0100 2786354 http://www.medworm.com/index.php?rid=2786353&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02213.x Eur J Clin Invest 2009 The tuberous sclerosis gene 2 product tuberin is an important regulator of the mammalian target of rapamycin (mTOR). In addition, tuberin is known to bind to the cyclin-dependent kinase (CDK) inhibitor p27Kip1 (p27) and to regulate its stability and localization via mTOR-independent mechanisms. Recently, evidence has been provided that tuberin also affects p27 localization via regulating mTOR's potential to activate the serum- and glucocorticoid-inducible kinase (SGK1) to phosphorylate p27. Taken together, these findings strengthen the argument that besides mTOR-inhibitors, such as rapamycin analogues, p27 and CDKs could also be considered targets for hamartoma therapeutics in tuberous sclerosis. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2786353 Tue, 08 Sep 2009 23:00:00 +0100 2786353 http://www.medworm.com/index.php?rid=2693115&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02209.x Conclusions Telomeric overhang erosion does not participate in physiological ageing but support a role for eroded telomeric overhangs and abnormal telomere structure in pathological shortening of telomeres, especially caused by loss-of-function telomerase mutations. Disrupted telomere structure caused by short telomeric overhangs may contribute to the mechanisms of abnormal haematopoietic compartment senescence and chromosomal instability in human bone marrow failure. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2693115 Wed, 12 Aug 2009 23:00:00 +0100 2693115 http://www.medworm.com/index.php?rid=2693116&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02207.x Conclusions Our findings suggest a complex interaction between CXCL16 and HIV, promoting both inflammatory and anti-inflammatory effects as well as HIV replication, partly dependent on accompanying HIV replication. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2693116 Mon, 10 Aug 2009 23:00:00 +0100 2693116 http://www.medworm.com/index.php?rid=2672031&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02203.x Conclusion Intensive insulin treatment may protect against renal injury in early DN by reducing the urinary MCP-1 and ICAM-1 excretions. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2672031 Tue, 04 Aug 2009 23:00:00 +0100 2672031 http://www.medworm.com/index.php?rid=2649660&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02187.x Conclusions Biles with cholesterol stones show high CSI and total protein concentration, and rapid COT, which is even faster in patients with multiple stones and high protein concentration. Low PSH levels in cholesterol stone patients point to a biochemical shift, potentially able to affect cholesterol crystallization. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2649660 Tue, 28 Jul 2009 23:00:00 +0100 2649660 http://www.medworm.com/index.php?rid=2649661&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02199.x Eur J Clin Invest 2009 Surgical treatment of abdominal wall hernia has been based for many decades on observational evidence, as the disease physiopathology was ambiguous. The long-standing hypothesis of abnormal collagen metabolism as a causative factor of hernia disease seems to become substantiated by modern investigations, demonstrating a link between abnormal matrix metalloproteinase (MMP) expression and abdominal wall hernia. Current evidence suggests a strong correlation between MMP-2 and direct inguinal hernia, while the role of this MMP in indirect, incisional and recurrent hernias has not been completely elucidated yet. Furthermore, MMP-1 and MMP-13 seem to be implicated in the physiopathology of recurrent hernia, while limited data link MMP-1 also with incisional hernia formatio... European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2649661 Sun, 26 Jul 2009 23:00:00 +0100 2649661 http://www.medworm.com/index.php?rid=2631151&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02198.x Conclusions These data show that PPAR[gamma]2 mRNA is expressed differently in the two types of MO patients and is associated with IR. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2631151 Thu, 23 Jul 2009 23:00:00 +0100 2631151 http://www.medworm.com/index.php?rid=2631152&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02189.x Conclusion This study demonstrates a strong inverse association between serum albumin and mortality in a large patient cohort. The predictive value of low albumin was remarkably higher in men than in women. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2631152 Wed, 22 Jul 2009 23:00:00 +0100 2631152 http://www.medworm.com/index.php?rid=2614147&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02195.x Conclusions The prevalence of NCF2 mutant families is approximately 15% in our series of 40 CGD families. This high incidence of A67 CGD in Turkey is undoubtedly caused by the high incidence of consanguineous marriages. We found three new mutations in NCF2 and one previously described. These are presented together with an overview of all NCF2 mutations now known. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2614147 Fri, 17 Jul 2009 23:00:00 +0100 2614147 http://www.medworm.com/index.php?rid=2614148&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02166.x Conclusions High-level amoxicillin resistance is associated with [beta]-lactamase production in H. pylori. Low-level amoxicillin resistance is linked to a point mutation on pbp1A. Because H. pylori can exchange DNA through natural transformation, spreading of blaTEM-1 amoxicillin resistance gene among H. pylori is a potential threat when treating H. pylori infection. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2614148 Thu, 16 Jul 2009 23:00:00 +0100 2614148 http://www.medworm.com/index.php?rid=2598960&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02165.x Conclusions Chronic treatment with CERA protects cardiac tissue in diabetic animals, i.e. it inhibits molecular pathways of cardiac fibrosis, and the effects are dose-dependent. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2598960 Mon, 13 Jul 2009 23:00:00 +0100 2598960 http://www.medworm.com/index.php?rid=2598959&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02197.x Conclusions All these findings confirm EPO as a new factor involved in regenerative processes, also suggesting a potential, future utility for new therapeutical applications in the field of human regenerative medicine. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2598959 Mon, 13 Jul 2009 23:00:00 +0100 2598959 http://www.medworm.com/index.php?rid=2593425&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02196.x (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2593425 Sat, 11 Jul 2009 23:00:00 +0100 2593425 http://www.medworm.com/index.php?rid=2589194&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02193.x Conclusions Mechanical stress enhanced apoptosis and GADD153 expression in cardiomyocytes. Treatment with PBA reversed both GADD153 expression and apoptosis induced by mechanical stress in cardiomyocytes. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2589194 Thu, 09 Jul 2009 23:00:00 +0100 2589194 http://www.medworm.com/index.php?rid=2581586&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02194.x (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2581586 Wed, 08 Jul 2009 23:00:00 +0100 2581586 http://www.medworm.com/index.php?rid=2571481&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02192.x Conclusion In this study, we provide direct functional evidence for the stimulation of coronary arteriogenesis via ECP in patients with stable coronary artery disease. These data might open a novel noninvasive and preventive treatment avenue for patients with non-acute vascular stenotic disease. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2571481 Sat, 04 Jul 2009 23:00:00 +0100 2571481 http://www.medworm.com/index.php?rid=2535667&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02191.x Background Metabolic syndrome (MetS) is an important risk factor of cardiovascular disease (CVD) and type 2 diabetes. Previous studies have suggested an inverse relationship between physical activity and MetS. However, these findings were inconsistent, and few investigators have examined these associations among South Americans. We estimated the prevalence of MetS and its association with leisure time physical activity (LTPA) among Peruvian adults.Materials and methods This cross-sectional study of 1675 individuals (619 men and 1056 women) was conducted among residents in Lima and Callao, Peru. Information about LTPA, socio-demographical and other lifestyle characteristics was collected by interview. The presence of MetS was defined using the Adult Treatment Panel III criteria.Results Over... European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2535667 Fri, 26 Jun 2009 23:00:00 +0100 2535667 http://www.medworm.com/index.php?rid=2535671&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02179.x Post-prandial lipaemia has emerged as a key contributor to cardiovascular disease (CVD) risk and progression. Specifically, delayed clearance of chylomicrons (CM) and their remnants increase the delivery of triglyceride and cholesteryl ester to the vessel wall and can accelerate the progression of atherosclerosis, which may be particularly pertinent to individuals with insulin resistance and/or obesity. As the number of studies linking post-prandial metabolism and chronic disease increases, interest has grown in the use of parameters reflecting CM metabolism as a possible indicator of early CVD risk. This, in turn has raised the question of what method might be most appropriate to detect CM and their remnants in plasma accurately. However, the handful of techniques able to measure CM metab... European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2535671 Thu, 25 Jun 2009 23:00:00 +0100 2535671 http://www.medworm.com/index.php?rid=2535670&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02182.x Conclusions Hepcidin levels in stable haemodialysis patients appear to reflect systemic iron load, but not inflammation. Due to the negative association between reticulocyte counts and hepcidin, the reduction of circulating hepcidin concentrations by dialysis and/or rhEpo treatment may positively affect erythropoiesis. Eur J Clin Invest 2009 (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2535670 Thu, 25 Jun 2009 23:00:00 +0100 2535670 http://www.medworm.com/index.php?rid=2535669&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02185.x Conclusions Monocytic activation is differentially regulated by fatty acids and depends on triglyceride levels in T2D. The main finding of the present study shows that eicosapentaenoic acid inhibits the specific binding of LPS to TLR4/MD-2. Eicosapentaenoic acid represents a new anti-inflammatory LPS-antagonist. Eur J Clin Invest 2009 (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2535669 Thu, 25 Jun 2009 23:00:00 +0100 2535669 http://www.medworm.com/index.php?rid=2535668&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02190.x Conclusions Choline administration reduces oxidative stress possibly by modulating the redox status of the cell and inhibits inflammatory response in a mouse model. Eur J Clin Invest 2009 (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2535668 Thu, 25 Jun 2009 23:00:00 +0100 2535668 http://www.medworm.com/index.php?rid=2535672&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02174.x Conclusion To our knowledge this is a rare case of co-existence of two pheochromocytoma-related genetic syndromes, and generates the question of whether all patients with these syndromes should undergo a thorough clinical and laboratory investigation for the possibility of another co-existing pheochromocytoma-related genetic syndrome. Eur J Clin Invest 2009; (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2535672 Wed, 24 Jun 2009 23:00:00 +0100 2535672 http://www.medworm.com/index.php?rid=2535673&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02188.x Conclusion The obtained results revealed the direct ability of resveratrol to reduce leptin secretion from isolated rat adipocytes. Resveratrol is therefore a compound affecting the endocrine function of adipocytes. Eur J Clin Invest 2009 (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2535673 Tue, 23 Jun 2009 23:00:00 +0100 2535673 http://www.medworm.com/index.php?rid=2535674&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02178.x (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2535674 Mon, 22 Jun 2009 23:00:00 +0100 2535674 http://www.medworm.com/index.php?rid=2535675&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02186.x Conclusions Our data suggest that celastrol inhibits the production of inflammatory mediators and is a potential target for the treatment of various inflammatory diseases. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2535675 Sun, 21 Jun 2009 23:00:00 +0100 2535675 http://www.medworm.com/index.php?rid=2535678&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02176.x Conclusions The fenofibrate directly inhibits monocyte binding by TNF-[alpha]-activated HAECs, probably through preventing up-regulation of cell adhesion molecules by endothelial cells in response to inflammatory stimuli. This PPAR[alpha] activator may have the potential to ameliorate vascular inflammation in patients with CHF. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2535678 Sun, 14 Jun 2009 23:00:00 +0100 2535678 http://www.medworm.com/index.php?rid=2535682&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02183.x Conclusion The AT1-antagonist TEL reduced myocardial hypertrophy and interstitial fibrosis in TGF-[beta]1-TG mice by normalizing MMP/TIMP ratio. [beta]1-Adrenergic inhibition by MET as well as TGF-[beta]1 antagonism induced antihypertrophic rather than antifibrotic effects. Inhibition of both renin-angiotensin system and [beta]1-adrenergic system may exert different but synergistic effects to reduce myocardial remodelling. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2535682 Thu, 11 Jun 2009 23:00:00 +0100 2535682 http://www.medworm.com/index.php?rid=2535680&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02171.x Conclusion This effect could be relevant in separating graft-vs.-host from the graft-vs.-tumour effect, especially considering the possibility of modulating T-lymphocytes activity by the immunomodulating drugs now available. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2535680 Thu, 11 Jun 2009 23:00:00 +0100 2535680 http://www.medworm.com/index.php?rid=2535679&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02181.x Conclusions Vascular hyporesponsiveness to angiotensin II in CCl4 rats is due to enhanced interaction of the AT1 receptor with [beta]-arrestin-2 and consecutively changed receptor function. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2535679 Thu, 11 Jun 2009 23:00:00 +0100 2535679 http://www.medworm.com/index.php?rid=2535677&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02180.x Conclusion Severe RAS in patients with symptomatic PAD is an independent predictor of major adverse cardiovascular events, adverse renal outcome and mortality. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2535677 Thu, 11 Jun 2009 23:00:00 +0100 2535677 http://www.medworm.com/index.php?rid=2535676&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02184.x Conclusions In summary, tryptase is a new diagnostic marker of myeloid neoplasms and a useful test in clinical haematology. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2535676 Thu, 11 Jun 2009 23:00:00 +0100 2535676 http://www.medworm.com/index.php?rid=2535684&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02167.x Conclusions In hepatocytes from normal rats, the quercetin-induced decrease in both de novo fatty acid and TAG synthesis, with a consequent reduction in VLDL-TAG formation, may represent a potential mechanism contributing to the reported hypotriacylglycerolemic effect of quercetin. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2535684 Sun, 07 Jun 2009 23:00:00 +0100 2535684 http://www.medworm.com/index.php?rid=2535683&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02141.x Conclusions The phenotype of partial monosomy X and partial trisomy 1q is much attenuated in case of unbalanced translocation (X;1) in adulthood probably owing to skewed X inactivation in derivative X chromosome. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2535683 Sun, 07 Jun 2009 23:00:00 +0100 2535683 http://www.medworm.com/index.php?rid=2535685&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02173.x Conclusion Among patients with eGFR between 30 and 60 mL min[minus]1 1·73 m[minus]2 undergoing coronary angiography, oral administration of N-acetylcysteine + theophylline in addition to saline hydration has a beneficial effect in the prevention of CIN. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2535685 Wed, 03 Jun 2009 23:00:00 +0100 2535685 http://www.medworm.com/index.php?rid=2535687&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02161.x Conclusions Initiation of prospective studies on the impact of gender as primary outcome and investigation of gender-related pathophysiological mechanisms of chronic diseases will help to improve patient care and to implement evidence-based gender-specific prevention programs and clinical recommendations in future. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2535687 Tue, 02 Jun 2009 23:00:00 +0100 2535687 http://www.medworm.com/index.php?rid=2535686&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02164.x Conclusion IgG4 in the bronchoalveolar lavage was seen at remarkably increased levels and IgG4-positive plasma cells were identified in the pulmonary lesions of patients with autoimmune pancreatitis. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2535686 Tue, 02 Jun 2009 23:00:00 +0100 2535686 http://www.medworm.com/index.php?rid=2535689&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02163.x Conclusions These findings suggest that ezetimibe improves fasting lipoprotein profiles and postprandial hyperlipidaemia by suppressing intestinal CM production in patients with type IIb hyperlipidaemia and such treatment may prove to be effective in reducing atherosclerosis. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2535689 Tue, 26 May 2009 23:00:00 +0100 2535689 http://www.medworm.com/index.php?rid=2535688&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02160.x Conclusions This study demonstrates that segmental pulmonary vein isolation in preventing AF recurrence is similar to amiodarone plus losartan, but it is superior to CPVA and amiodarone alone in patients with paroxysmal AF. Larger multicentre studies are needed to confirm its long-term outcomes. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2535688 Tue, 26 May 2009 23:00:00 +0100 2535688 http://www.medworm.com/index.php?rid=2535692&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02169.x Conclusions In newly diagnosed, never-treated-earlier hypertensive subjects with no evidence of hypertensive cardiomyopathy, the cardiac response to exercise is dependent on adequate diastolic filling volume to maintain systolic performance. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2535692 Mon, 25 May 2009 23:00:00 +0100 2535692 http://www.medworm.com/index.php?rid=2535691&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02168.x Conclusions Haemophilia A patients with factor VIII inhibitors have low thrombin generation. After rVIIa, the extent of coagulation activation as measured by levels of F1 + 2 is increased, but thrombin generation is restored to only 20%. Peak thrombin levels could reflect the effects of rVIIa on coagulation mechanisms, and their relevance with regard to the clinical coagulation defect of haemophilia A patients with factor VIII inhibitors might be evaluated. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2535691 Mon, 25 May 2009 23:00:00 +0100 2535691 http://www.medworm.com/index.php?rid=2535690&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02158.x Conclusions Morbidly obese, normoglycaemic and normotensive young women have increased HR and low HRV, indicating an abnormal cardiac autonomic function and representing a risk factor for adverse cardiovascular events. A decrease of HRV parameters is associated with a progressive increase of body FM. Other metabolic and hormonal factors, characterising obesity, do not show an independent influence on these HRV alterations. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2535690 Mon, 25 May 2009 23:00:00 +0100 2535690 http://www.medworm.com/index.php?rid=2535693&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02170.x Conclusions This study indicates that monocytic CD163 and systemic sCD163 are elevated in T2D and obesity. Adiponectin reduces CD163 in vitro, but additional factors related to obesity like IL-6 may be more relevant in vivo. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2535693 Wed, 20 May 2009 23:00:00 +0100 2535693 http://www.medworm.com/index.php?rid=2535694&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02159.x (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2535694 Tue, 19 May 2009 23:00:00 +0100 2535694 http://www.medworm.com/index.php?rid=2535695&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02136.x Conclusions Our data indicate that parabolic flight induces priming of the cytotoxic capabilities of PMNs without affecting microbicidal functions. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2535695 Thu, 14 May 2009 23:00:00 +0100 2535695 http://www.medworm.com/index.php?rid=2535696&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2362.2009.02155.x Conclusions Patients with various clinical manifestations of vascular diseases in the highest HDL-c quintile have a lower risk for vascular events compared with patients in the lowest HDL-c quintile. Further, the current results expand the evidence by showing that also in a cohort of patients with various localisations of clinical evident vascular disease, in which statins were widely used, higher HDL-c levels confer a lower risk for developing new vascular events, irrespective of the localisation of vascular disease, use of lipid-lowering medication and plasma LDL-c concentration. (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2535696 Mon, 11 May 2009 23:00:00 +0100 2535696 http://www.medworm.com/index.php?rid=2289229&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19292881%26dopt%3DAbstract CONCLUSIONS: Our study shows that the involvement of antioxidants in CAD is related to patients' characteristics. These findings may be relevant in planning antioxidant therapies. PMID: 19292881 [PubMed - in process] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2289229 Thu, 26 Mar 2009 02:15:23 +0100 2289229 http://www.medworm.com/index.php?rid=2289228&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19292882%26dopt%3DAbstract CONCLUSION: The negative inotropic effect of L-NMMA may be a result of an increase in coronary vascular resistance and a resultant decrease in myocardial perfusion. The reduction in CI may also result from a direct reduction of the normal positive inotropic effect of NO by L-NMMA which is closely correlated with its effects on SVRI. PMID: 19292882 [PubMed - in process] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2289228 Thu, 26 Mar 2009 02:14:59 +0100 2289228 http://www.medworm.com/index.php?rid=2289227&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19292883%26dopt%3DAbstract CONCLUSIONS: It was concluded that the Na(+)/K(+) ATPase and Na(+)K(+)2Cl(-) are both targets of TNF-alpha and the effect of the cytokine favours cell survival over cell death. PMID: 19292883 [PubMed - in process] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2289227 Thu, 26 Mar 2009 02:14:37 +0100 2289227 http://www.medworm.com/index.php?rid=2289226&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19292884%26dopt%3DAbstract CONCLUSION: In conclusion, our results suggest that chronic renal failure could contribute to the damage of DNA at all organs evaluated, except to the brain cells. As DNA damage is an important step in events leading to carcinogenesis, this study represents a relevant contribution to the correct evaluation of the potential health risks associated with kidney disease. PMID: 19292884 [PubMed - in process] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2289226 Thu, 26 Mar 2009 02:14:26 +0100 2289226 http://www.medworm.com/index.php?rid=2289225&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19292885%26dopt%3DAbstract CONCLUSIONS: This study demonstrates that simvastatin enhances the production of osteogenic proteins in bone and this effect may contribute to the prevention of bone loss in OVX rats. PMID: 19292885 [PubMed - in process] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2289225 Thu, 26 Mar 2009 02:14:21 +0100 2289225 http://www.medworm.com/index.php?rid=2289224&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19292886%26dopt%3DAbstract CONCLUSIONS: From these data, we conclude that CD98hc is expressed in RCCs, whereby the extent of expression is likely to correlate directly with grade of malignancy. In pRCCs, CD98hc might represent a novel and reliable marker for type II pRCC. PMID: 19292886 [PubMed - in process] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2289224 Thu, 26 Mar 2009 02:14:17 +0100 2289224 http://www.medworm.com/index.php?rid=2289223&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19292887%26dopt%3DAbstract CONCLUSIONS: In our series of 40 CGD families, approximately 25% of the families have p22-phox defects, with six different mutations, including three novel mutations. The high rate of consanguineous marriages seems to be the underlying aetiology. PMID: 19292887 [PubMed - in process] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2289223 Thu, 26 Mar 2009 02:14:05 +0100 2289223 http://www.medworm.com/index.php?rid=2289222&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19292888%26dopt%3DAbstract CONCLUSIONS: Our results suggest that PDGF-C may play an important role in endothelium in normal and atherosclerotic arteries and in macrophages in lesions. PDGF-D was expressed in all types of lesions with the same intensity and thus differs from the expression of PDGF-C. PMID: 19292888 [PubMed - in process] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2289222 Thu, 26 Mar 2009 02:13:56 +0100 2289222 http://www.medworm.com/index.php?rid=2289221&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19292889%26dopt%3DAbstract CONCLUSIONS: Our findings suggest that impaired elastic fibre function in the transversalis fascia of patients with direct inguinal hernia, reflected by diminished elastin synthesis and its enhanced enzyme degradation, contributes to the development of this type of hernia. PMID: 19292889 [PubMed - in process] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2289221 Thu, 26 Mar 2009 02:13:49 +0100 2289221 http://www.medworm.com/index.php?rid=2289220&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19297801%26dopt%3DAbstract Authors: Little J, Higgins JP, Ioannidis JP, Moher D, Gagnon F, von Elm E, Khoury MJ, Cohen B, Davey-Smith G, Grimshaw J, Scheet P, Gwinn M, Williamson RE, Zou GY, Hutchings K, Johnson CY, Tait V, Wiens M, Golding J, van Duijn C, McLaughlin J, Paterson A, Wells G, Fortier I, Freedman M, Zecevic M, King R, Infante-Rivard C, Stewart A, Birkett N Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information in the practice of medicine and public health. Assessment of the strengths and weaknesses of this evidence, and hence the ability to synthesize it, has been limited by inadequate reporting of results. The STrengthening the REporting of Genetic Association studies (STREGA) initia... European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2289220 Thu, 26 Mar 2009 02:13:43 +0100 2289220 http://www.medworm.com/index.php?rid=2252352&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19254321%26dopt%3DAbstract Authors: PMID: 19254321 [PubMed - in process] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2252352 Wed, 11 Mar 2009 15:49:27 +0100 2252352 http://www.medworm.com/index.php?rid=2231227&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19254321%26dopt%3DAbstract ESCI 2009. Eur J Clin Invest. 2009 Apr;39(s1Abstracts of the 43rd Annual Scientific Meeting of the European Society for Clinical Investigation, 1-4 April 2009, Frankfurt/Main, Germany):iv-vii Authors: PMID: 19254321 [PubMed - as supplied by publisher] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2231227 Wed, 04 Mar 2009 16:24:47 +0100 2231227 http://www.medworm.com/index.php?rid=2231226&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19254322%26dopt%3DAbstract Authors: PMID: 19254322 [PubMed - as supplied by publisher] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2231226 Wed, 04 Mar 2009 16:24:43 +0100 2231226 http://www.medworm.com/index.php?rid=2231225&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19254323%26dopt%3DAbstract Authors: PMID: 19254323 [PubMed - as supplied by publisher] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2231225 Wed, 04 Mar 2009 16:24:40 +0100 2231225 http://www.medworm.com/index.php?rid=2231224&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19254324%26dopt%3DAbstract Authors: PMID: 19254324 [PubMed - as supplied by publisher] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2231224 Wed, 04 Mar 2009 16:24:36 +0100 2231224 http://www.medworm.com/index.php?rid=2177166&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19200161%26dopt%3DAbstract Authors: van Raalte DH, Ouwens DM, Diamant M At pharmacological concentrations, glucocorticoids (GCs) display potent anti-inflammatory effects, and are therefore frequently prescribed by physicians to treat a wide variety of diseases. Despite excellent efficacy, GC therapy is hampered by their notorious metabolic side effect profile. Chronic exposure to increased levels of circulating GCs is associated with central adiposity, dyslipidaemia, skeletal muscle wasting, insulin resistance, glucose intolerance and overt diabetes. Remarkably, many of these side-effects of GC treatment resemble the various components of the metabolic syndrome (MetS), in which indeed subtle disturbances in the hypothalamic-pituitary-adrenal (HPA) axis and/or increased tissue sensitivity to GCs have been reporte... European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2177166 Sun, 01 Feb 2009 05:00:00 +0100 2177166 http://www.medworm.com/index.php?rid=2177165&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19200162%26dopt%3DAbstract Conclusions Mild-to-moderate obesity in prepubertal boys without insulin resistance is associated with impaired endothelial function and blunted muscle perfusion response to local dynamic exercise without alteration of vascular smooth muscle reactivity. PMID: 19200162 [PubMed - in process] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2177165 Sun, 01 Feb 2009 05:00:00 +0100 2177165 http://www.medworm.com/index.php?rid=2177164&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19200163%26dopt%3DAbstract Conclusion This study showed good reproducibility of a novel platelet function test using stainless steel as an agonist and showed correlation with validated platelet function tests. We found that the novel platelet function test is a suitable test for measurement of platelet aggregation inhibition in patients undergoing stenting for STEMI, even when they are taking multiple antiplatelet regimens. PMID: 19200163 [PubMed - in process] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2177164 Sun, 01 Feb 2009 05:00:00 +0100 2177164 http://www.medworm.com/index.php?rid=2177163&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19200164%26dopt%3DAbstract Conclusions Myocardial bridging is not a benign variation of coronary anatomy. It is associated with angina and myocardial infarction in patients with >/= 70% systolic compression. The bridged segment may be a cause of enhanced atherosclerotic plaque formation. PMID: 19200164 [PubMed - in process] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2177163 Sun, 01 Feb 2009 05:00:00 +0100 2177163 http://www.medworm.com/index.php?rid=2177162&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19200165%26dopt%3DAbstract Conclusions We demonstrate that in both mild and severe glomerular damage, lack of nidogen-2 is associated with: (i) increased mesangioproliferation; (ii) higher mesangial matrix expansion; and (iii) reduction in glomerular capillary supply. These findings suggest a critical role for nidogen-2 in the maintenance of glomerular structure in the diseased kidney. PMID: 19200165 [PubMed - in process] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2177162 Sun, 01 Feb 2009 05:00:00 +0100 2177162 http://www.medworm.com/index.php?rid=2177161&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19200166%26dopt%3DAbstract Conclusions hBD-4 may play a significant role in H. pylori associated gastritis. Inconsistent expression of RNase 7 does not support a pivotal role for this peptide in response to infection with H. pylori. PMID: 19200166 [PubMed - in process] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2177161 Sun, 01 Feb 2009 05:00:00 +0100 2177161 http://www.medworm.com/index.php?rid=2177160&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19200167%26dopt%3DAbstract Conclusions The proposed cut-off for normal sucralose excretion is 2.11%, but its high variability and lack of association to gastrointestinal permeability or clinical outcome leave it open, if it can provide information beyond established permeability tests. PMID: 19200167 [PubMed - in process] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2177160 Sun, 01 Feb 2009 05:00:00 +0100 2177160 http://www.medworm.com/index.php?rid=2177159&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19200168%26dopt%3DAbstract Conclusions These results indicate that Smad3 loss confers resistance to the development of TNBS-induced colonic fibrosis. The reduced fibrotic response appears to be due to a reduction in fibrogenic mesenchymal cell activation and ECM production and accumulation. Smad3 could be a novel target for potential treatment of intestinal fibrosis, especially in inflammatory bowel disease. PMID: 19200168 [PubMed - in process] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2177159 Sun, 01 Feb 2009 05:00:00 +0100 2177159 http://www.medworm.com/index.php?rid=2177158&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19200169%26dopt%3DAbstract Conclusions It suggests that TLR4 negatively regulates paclitaxel chemotherapy and MyD88 is an essential downstream factor to TLR4 signalling for this resistance. Knockdown of TLR4 induces paclitaxel chemosensitivity which might depress the Akt pathway. The TLR4-MyD88 signalling represents an important source to promote tumour growth. PMID: 19200169 [PubMed - in process] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2177158 Sun, 01 Feb 2009 05:00:00 +0100 2177158 http://www.medworm.com/index.php?rid=2051433&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19087125%26dopt%3DAbstract Conclusions The QED and IVMD predict reverse remodelling and survival following CRT. These parameters are easy to obtain, provide valuable prognostic information, and should thus be measured in CRT candidates evaluated by echocardiography. PMID: 19087125 [PubMed - in process] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2051433 Sat, 20 Dec 2008 08:23:41 +0100 2051433 http://www.medworm.com/index.php?rid=2051432&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19087127%26dopt%3DAbstract Conclusions These results suggest that increased plasma levels of EMPs may be an initial step in the development of endothelial dysfunction in genetically predisposed subjects. PMID: 19087127 [PubMed - in process] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2051432 Sat, 20 Dec 2008 08:23:35 +0100 2051432 http://www.medworm.com/index.php?rid=2051431&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19087128%26dopt%3DAbstract Conclusions The percentage of potentially misclassified cases of subclinical hypothyroidism and hypothyroxinaemia in pregnant women decreased by using the gestational age-specific reference intervals as a diagnostic criteria during the first half of pregnancy. PMID: 19087128 [PubMed - in process] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2051431 Sat, 20 Dec 2008 08:23:31 +0100 2051431 http://www.medworm.com/index.php?rid=2051430&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19087129%26dopt%3DAbstract Conclusions Simultaneous carbimazole reduces the euthyroidism rate, the aim of low-dose radioiodine therapy, over the entire target dose range in both Graves' disease and toxic nodular goitre. Therefore, antithyroid drug discontinuation should be preferred in low-dose radioiodine therapy. Conversely, escalation of the target dose should be preferred in high-dose radioiodine therapy. PMID: 19087129 [PubMed - in process] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2051430 Sat, 20 Dec 2008 08:23:27 +0100 2051430 http://www.medworm.com/index.php?rid=2051429&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19087130%26dopt%3DAbstract Conclusions Urinary BA output increases and flat-BAs reappear in urine during human liver regeneration. These results suggest that determination of BAs in urine may be an interesting parameter obtained by non-invasive techniques whose actual clinical value during human liver regeneration warrants further evaluation. PMID: 19087130 [PubMed - in process] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2051429 Sat, 20 Dec 2008 08:23:24 +0100 2051429 http://www.medworm.com/index.php?rid=2051428&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19087131%26dopt%3DAbstract Conclusions Our study suggests that aetiology of cirrhosis has an impact on 1-year survival predicted by the MELD score. This becomes more apparent in patients with advanced stage of liver disease (MELD >/= 16). Since MELD score is used for ranking patients for liver transplantation and waiting times are regularly longer than 3 months, our observations suggest that with increasing time on the waiting list and severity of disease, patients with viral cirrhosis may have a disadvantage in the current allocation policy. PMID: 19087131 [PubMed - in process] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2051428 Sat, 20 Dec 2008 08:23:19 +0100 2051428 http://www.medworm.com/index.php?rid=2051427&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19087132%26dopt%3DAbstract Conclusions Different methods result in different levels and reproducibility of nNO. In regard to this, methods of humming and breath holding are recommended for standardised measurement of nasal NO. PMID: 19087132 [PubMed - in process] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2051427 Sat, 20 Dec 2008 08:23:15 +0100 2051427 http://www.medworm.com/index.php?rid=2051426&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19087133%26dopt%3DAbstract Authors: Kimata H, Morita A, Furuhata S, Itakura H, Ikenobu K, Kimura Y PMID: 19087133 [PubMed - in process] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2051426 Sat, 20 Dec 2008 08:23:11 +0100 2051426 http://www.medworm.com/index.php?rid=2032140&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19067734%26dopt%3DAbstract Conclusions Oxidative stress causes the regulations of PPAR-alpha and PPAR-gamma in the TNF-alpha-treated cardiomyocytes. The up-regulation of PPAR-gamma by PPAR ligands may contribute to their anti-inflammation effects. Eur J Clin Invest 2009; ?? (?): 000-000. PMID: 19067734 [PubMed - as supplied by publisher] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2032140 Mon, 01 Dec 2008 05:00:00 +0100 2032140 http://www.medworm.com/index.php?rid=2032139&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19067735%26dopt%3DAbstract Conclusions The ARR is a good parameter in the screening for PA. The SUSPPUP ratio is a cheap and rapid tool to assess the extent of mineralocorticoid excess and, therefore, can be offered to more patients. In addition, the application of the SUSPPUP ratio can be extended to patients who suffer from other forms of mineralocorticoid hypertension (e.g. with low aldosterone levels). Eur J Clin Invest 2009; ?? (?): 000-000. PMID: 19067735 [PubMed - as supplied by publisher] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2032139 Mon, 01 Dec 2008 05:00:00 +0100 2032139 http://www.medworm.com/index.php?rid=2032138&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19067736%26dopt%3DAbstract Conclusions This pilot study demonstrates that in an early state of EH, inflammatory pathways have already been activated. Besides classical pro-inflammatory cytokines, VEGF serum levels are significantly elevated. The positive correlation of VEGF with MCP-1 is suggestive for the already described induction of MCP-1 via VEGF. Eur J Clin Invest 2009; 39 (?): 000-000. PMID: 19067736 [PubMed - as supplied by publisher] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=2032138 Mon, 01 Dec 2008 05:00:00 +0100 2032138 http://www.medworm.com/index.php?rid=1995404&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19021711%26dopt%3DAbstract CONCLUSION: A strong relationship between intramural pH and elastin net destruction suggests that the local alkaline status within the thin thrombus-covered part of the aneurysm wall is contributing to the elastinolytic process. PMID: 19021711 [PubMed - in process] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=1995404 Sat, 29 Nov 2008 06:46:35 +0100 1995404 http://www.medworm.com/index.php?rid=1979340&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19021711%26dopt%3DAbstract Conclusion A strong relationship between intramural pH and elastin net destruction suggests that the local alkaline status within the thin thrombus-covered part of the aneurysm wall is contributing to the elastinolytic process. PMID: 19021711 [PubMed - as supplied by publisher] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=1979340 Sun, 23 Nov 2008 06:46:56 +0100 1979340 http://www.medworm.com/index.php?rid=1979339&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19021712%26dopt%3DAbstract Conclusions Our results document for the first time that exercise induce coronary microvascular and myocardial defects in BS/GS patients. Therefore, this may challenge the idea that BS/GS are benign diseases. In addition, the diagnostic approach to these syndromes should include an in-depth cardiac assessment in order to identify patients at higher risk. PMID: 19021712 [PubMed - as supplied by publisher] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=1979339 Sun, 23 Nov 2008 06:46:53 +0100 1979339 http://www.medworm.com/index.php?rid=1979338&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19021713%26dopt%3DAbstract Conclusions Our data suggest that parental MI at an early age is a strong and independent predictor of HF with antecedent MI among US male physicians. This information, along with existing tools, may help clinicians identify patients at risk of HF with antecedent MI. PMID: 19021713 [PubMed - as supplied by publisher] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=1979338 Sun, 23 Nov 2008 06:46:50 +0100 1979338 http://www.medworm.com/index.php?rid=1979337&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19021714%26dopt%3DAbstract Conclusions The effect of post-ischaemic effluent is mediated by the protein kinase A-dependent prostaglandin-receptor subtypes EP2 and EP4 downstream of cyclooxygenase-2. PMID: 19021714 [PubMed - as supplied by publisher] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=1979337 Sun, 23 Nov 2008 06:46:47 +0100 1979337 http://www.medworm.com/index.php?rid=1979336&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19021715%26dopt%3DAbstract Conclusions The majority of patients with Fabry's disease were able to augment stroke volume during exercise by increasing end-diastolic volume, whereas patients with more advanced cardiac involvement may experience the inability to increase cardiac output by the Frank Starling mechanism. PMID: 19021715 [PubMed - as supplied by publisher] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=1979336 Sun, 23 Nov 2008 06:46:44 +0100 1979336 http://www.medworm.com/index.php?rid=1979335&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19021716%26dopt%3DAbstract Conclusion The over-representation of genes belonging to immunity/defence, signal transduction, and apoptosis as found with semi-synthetic membranes suggests that full-synthetic membranes are more biocompatible than semi-synthetic membranes. PMID: 19021716 [PubMed - as supplied by publisher] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=1979335 Sun, 23 Nov 2008 06:46:40 +0100 1979335 http://www.medworm.com/index.php?rid=1979334&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19021717%26dopt%3DAbstract Conclusions DR is associated with increased IMT and endothelial dysfunction in T2DM. Impaired endothelial function may be a common denominator of pathogenesis of microvascular complications and atherosclerosis in T2DM. PMID: 19021717 [PubMed - as supplied by publisher] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=1979334 Sun, 23 Nov 2008 06:46:36 +0100 1979334 http://www.medworm.com/index.php?rid=1979333&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19021718%26dopt%3DAbstract Conclusions Patients with Wilms' tumours benefited from preoperative TACE treatment. PCNA expression was significantly lower in patients in the TACE group than those in the control group. There was no significant difference on VEGF expression between the patients in TACE and control groups. PMID: 19021718 [PubMed - as supplied by publisher] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=1979333 Sun, 23 Nov 2008 06:46:33 +0100 1979333 http://www.medworm.com/index.php?rid=1979332&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19021719%26dopt%3DAbstract Conclusion In hepatic cirrhosis ascites can be regarded as an ultrafiltrate of plasma RAAS components. Since differences in molecular weight or metabolic rate cannot explain the low ascites-to-plasma ratio of renin and prorenin, either their transcapillary transport is impaired and/or they selectively bind to (pro)renin binding sites. PMID: 19021719 [PubMed - as supplied by publisher] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=1979332 Sun, 23 Nov 2008 06:46:29 +0100 1979332 http://www.medworm.com/index.php?rid=1979331&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19021720%26dopt%3DAbstract Conclusions Based on these data and similar published data we recommend selecting patients with MDS or secondary AML for SCT according to the presence of comorbidities. PMID: 19021720 [PubMed - as supplied by publisher] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=1979331 Sun, 23 Nov 2008 06:46:26 +0100 1979331 http://www.medworm.com/index.php?rid=1979330&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19021721%26dopt%3DAbstract Conclusions Our study suggests that low blood serotonin levels help define a sub-group of patients with mastocytosis that are more likely to present with neurological and gastrointestinal complaints, and suggests that the use of pharmacologic agents that alter blood serotonin levels could be explored in selected patients. PMID: 19021721 [PubMed - as supplied by publisher] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=1979330 Sun, 23 Nov 2008 06:46:23 +0100 1979330 http://www.medworm.com/index.php?rid=1979329&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19021722%26dopt%3DAbstract Conclusions Purified Der p 1 and Der p 2 are sufficient for the diagnosis of >/= 97% of D. pteronyssinus allergic patients in Europe, but other allergens may also play an important role for the diagnosis and treatment of HDM allergy. PMID: 19021722 [PubMed - as supplied by publisher] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=1979329 Sun, 23 Nov 2008 06:46:20 +0100 1979329 http://www.medworm.com/index.php?rid=1979328&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19021723%26dopt%3DAbstract We report a strikingly positive, late response to bortezomib in conjunction with pegylated liposomal doxorubicin in a 79-year old woman with multiple myeloma (MM). The patient obtained a partial remission after eight courses of therapy and a complete remission about 10 months after the end of therapy. This delayed complete remission may be similar to the spontaneous regression reported for other malignancies such as melanoma or lymphoma. We postulate that the immune response and a persistent anti-angiogenic effect of bortezomib could well explain the delayed complete remission in our patient. PMID: 19021723 [PubMed - as supplied by publisher] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=1979328 Sun, 23 Nov 2008 06:46:14 +0100 1979328 http://www.medworm.com/index.php?rid=1979364&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19021695%26dopt%3DAbstract Conclusions Genetic variants in the RAS genes may determine an individual's risk to develop DHF. There is also a synergistic gene-gene interaction between the RAS genes in the development of DHF. PMID: 19021695 [PubMed - as supplied by publisher] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=1979364 Sat, 01 Nov 2008 04:00:00 +0100 1979364 http://www.medworm.com/index.php?rid=1979362&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19021696%26dopt%3DAbstract Conclusion The stimulatory effect of PTH on endothelial VEGF-165 mRNA expression is partly through PKC and PKA pathways and is also NO dependent. PMID: 19021696 [PubMed - as supplied by publisher] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=1979362 Sat, 01 Nov 2008 04:00:00 +0100 1979362 http://www.medworm.com/index.php?rid=1979361&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19021697%26dopt%3DAbstract Conclusions The results show that low levels of serum fetuin-A are associated with increased mortality in HD patients only in the presence of inflammation. This suggests that coexistence of a low serum fetuin-A level and low-grade inflammation exerts an additive effect on the risk of death in HD patients. PMID: 19021697 [PubMed - as supplied by publisher] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=1979361 Sat, 01 Nov 2008 04:00:00 +0100 1979361 http://www.medworm.com/index.php?rid=1979360&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19021698%26dopt%3DAbstract Conclusions This study demonstrates that a therapeutic dose of celecoxib, but not piroxicam, could significantly attenuate fructose-induced whole body and muscular insulin resistance in rats. PMID: 19021698 [PubMed - as supplied by publisher] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=1979360 Sat, 01 Nov 2008 04:00:00 +0100 1979360 http://www.medworm.com/index.php?rid=1979355&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19021699%26dopt%3DAbstract Conclusions Our data confirm agonism of telmisartan, valsartan and lisinopril on PPARgamma. Pharmacokinetic differences may explain different potencies of PPARgamma stimulation by drugs acting on the renin-angiotensin system in clinical settings. PMID: 19021699 [PubMed - as supplied by publisher] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=1979355 Sat, 01 Nov 2008 04:00:00 +0100 1979355 http://www.medworm.com/index.php?rid=1979353&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19021700%26dopt%3DAbstract Conclusions Our results underline that determination of adiponectin isoforms are more useful than measurement of total adiponectin in clinical settings. Our data suggest that adiponectin concentrations are strongly associated with visceral fat area but not with insulin sensitivity. Thus, we hypothesize that insulin resistance is a consequence rather than the cause of hypoadiponectinaemia in obese subjects. PMID: 19021700 [PubMed - as supplied by publisher] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=1979353 Sat, 01 Nov 2008 04:00:00 +0100 1979353 http://www.medworm.com/index.php?rid=1979352&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19021701%26dopt%3DAbstract Conclusion A single oral administration of tilactase is highly effective in decreasing symptoms and hydrogen excretion of hypolactasia assessed by lactose H(2)-breath test. If confirmed by long-term observations, ingestion of tilactase might be a better option than exclusion diets in intolerant subjects with hypolactasia. PMID: 19021701 [PubMed - as supplied by publisher] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=1979352 Sat, 01 Nov 2008 04:00:00 +0100 1979352 http://www.medworm.com/index.php?rid=1979351&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19021702%26dopt%3DAbstract Conclusions As much as we are aware this is the first demonstration of the possible integration of HCV sequences into the DNA of HCV(+) patients. PMID: 19021702 [PubMed - as supplied by publisher] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=1979351 Sat, 01 Nov 2008 04:00:00 +0100 1979351 http://www.medworm.com/index.php?rid=1979350&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19021703%26dopt%3DAbstract Conclusions SU rats developed insulin resistance and hyperlipidaemia, accompanied with increased fat deposition in the heart and enhanced MMP protein expression. Conversely, ARG supplementation prevents these metabolic abnormalities and restored MMP/TIMP-1 balance. PMID: 19021703 [PubMed - as supplied by publisher] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=1979350 Sat, 01 Nov 2008 04:00:00 +0100 1979350 http://www.medworm.com/index.php?rid=1979349&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19021704%26dopt%3DAbstract Conclusions T cells in atherosclerotic plaques have the capacity to selectively respond to antigens of a wide variety of microbial antigens. This supports the view that such mechanisms could contribute to the atherosclerotic inflammatory response. PMID: 19021704 [PubMed - as supplied by publisher] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=1979349 Sat, 01 Nov 2008 04:00:00 +0100 1979349 http://www.medworm.com/index.php?rid=1979346&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19021705%26dopt%3DAbstract Conclusion Curve fitting, using (13)CO(2)- and H(2)-breath data, is a feasible and non-invasive method to assess carbohydrate digestion and fermentation after consumption of (13)C enriched starchy food. PMID: 19021705 [PubMed - as supplied by publisher] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=1979346 Sat, 01 Nov 2008 04:00:00 +0100 1979346 http://www.medworm.com/index.php?rid=1979345&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19021706%26dopt%3DAbstract Conclusions In a patient with rapidly progressing aggressive SM, neither 2CdA nor dasatinib produced a long-lasting response in vivo, despite encouraging in vitro results. For such patients, alternative treatment strategies have to be developed. PMID: 19021706 [PubMed - as supplied by publisher] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=1979345 Sat, 01 Nov 2008 04:00:00 +0100 1979345 http://www.medworm.com/index.php?rid=1979344&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19021707%26dopt%3DAbstract Authors: Bolignano D, Medici MA, Buemi M PMID: 19021707 [PubMed - as supplied by publisher] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=1979344 Sat, 01 Nov 2008 04:00:00 +0100 1979344 http://www.medworm.com/index.php?rid=1979343&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19021708%26dopt%3DAbstract Authors: Kapoor S PMID: 19021708 [PubMed - as supplied by publisher] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=1979343 Sat, 01 Nov 2008 04:00:00 +0100 1979343 http://www.medworm.com/index.php?rid=1979342&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19021709%26dopt%3DAbstract Authors: Latella G, Zanninelli G PMID: 19021709 [PubMed - as supplied by publisher] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=1979342 Sat, 01 Nov 2008 04:00:00 +0100 1979342 http://www.medworm.com/index.php?rid=1979341&cid=s_30440_22_f&fid=30440&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19021710%26dopt%3DAbstract ERRATUM. Eur J Clin Invest. 2008 Nov;38(11):881 Authors: PMID: 19021710 [PubMed - as supplied by publisher] (Source: European Journal of Clinical Investigation) European Journal of Clinical Investigation journals http://www.medworm.com/rss/comments.php?id=1979341 Sat, 01 Nov 2008 04:00:00 +0100 1979341