MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'European Journal of Clinical Pharmacology' source. Wed, 08 Feb 2012 14:04:14 +0100 http://www.medworm.com/index.php?rid=5667363&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw7jh3u6681352317%2F Conclusion  Unlicensed and off-label drug use is common. It is not illegal and may be clinically appropriate but is associated with a number of clinical, safety, and ethical issues. Regulatory authorities should use existing clinical evidence on the use of off-label and unlicensed drugs in decision making. Marketing authorization holders and national regulatory authorities should monitor for any safety concerns associated with unlicensed and off-label drug use and take appropriate measures as well as identify research priorities and mandate clinical studies to resolve important questions. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionPages 1-5DOI 10.1007/s00228-012-1221-xAuthors Goran Palčevski, Department of Paediatrics, University Hos... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5667363 Fri, 03 Feb 2012 17:51:14 +0100 5667363 http://www.medworm.com/index.php?rid=5667364&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F580225r476107755%2F Conclusions  MDD is associated with fewer changes in drug treatment compared with OP. Further studies of risks and benefits from this prescribing procedure are urged. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionPages 1-7DOI 10.1007/s00228-012-1230-9Authors Christina Sjöberg, Department of Geriatrics, Sahlgrenska University Hospital/Mölndal, 431 80 Mölndal, SwedenHenrik Ohlsson, Centre for Primary Health Care Research, Lund University/Region Skåne, Skåne University Hospital, Malmö, SwedenSusanna M Wallerstedt, Department of Clinical Pharmacology, Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden Journal European Journal of Clinical PharmacologyOnline ISSN 1432-1041Print ISSN 0031-6970 (Source: European Journal of Clin... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5667364 Fri, 03 Feb 2012 17:51:13 +0100 5667364 http://www.medworm.com/index.php?rid=5659925&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc88jg27n841840q6%2F Conclusions  The results of this study make several noteworthy contributions regarding national spontaneous reporting systems. The relevance of the PBRR for the measurement reporting activity is clearly supported by the current findings. This study also shows that there is a general trend towards increased reporting activity. This is maintained by regional centres and encouragement of reporting. A further study would be helpful to assess the effectiveness of reporting systems at both the national and European level. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionPages 1-7DOI 10.1007/s00228-012-1219-4Authors Jindrich Srba, Department of Social and Clinical Pharmacy, Faculty of Pharmacy, Charles University, Hradec Kralove, Czech RepublicVer... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5659925 Tue, 31 Jan 2012 16:47:45 +0100 5659925 http://www.medworm.com/index.php?rid=5659927&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F381868m065147084%2F Conclusions  As intake with a carbohydrate-rich meal is not recommended in the SPC of Zanidip because a twofold difference was considered to be clinically relevant, the intake of lercanidipine only 15 min before food intake does not seem to be consistent with this recommendation. The Marketing Authorisation Holder should clarify the dosing instructions in relation to meals and identify a sufficient time-lapse to ensure an exposure similar to that obtained in phase III clinical efficacy studies. Content Type Journal ArticleCategory Pharmacokinetics and DispositionPages 1-5DOI 10.1007/s00228-012-1215-8Authors Covadonga Álvarez, Departamento Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, 28... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5659927 Tue, 31 Jan 2012 16:47:44 +0100 5659927 http://www.medworm.com/index.php?rid=5659926&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb65w057t7510783j%2F Conclusions  We found that the SNP 4 IVS8-109T allele is associated with a higher CYP2C9 MR in healthy Swedish subjects, but further investigations need to be carried out to establish a molecular explanation for ultra-rapid CYP2C9-catalysed metabolism. Haplotype based on SNPs 1–4 did not seem to contribute to variation in the MR of the Korean subjects nor play a role in determining the MR of the Swedish ones. Content Type Journal ArticleCategory PharmacogeneticsPages 1-10DOI 10.1007/s00228-012-1210-0Authors Fazleen H. M. Hatta, Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet–Karolinska University Hospital, Huddinge 141 86, Stockholm, SwedenLay Kek Teh, Pharmacogenomics Centre (PROMISE), Faculty of Pharmacy, Universiti T... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5659926 Tue, 31 Jan 2012 16:47:44 +0100 5659926 http://www.medworm.com/index.php?rid=5648113&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft0147425030158ng%2F Conclusions  This is the first report that directly relates busulfan exposure to antifibrinolytic activity by PAI-1 and hypercoagulation possibly mediated by members of the TGF-β1 family. This suggests further research to evaluate activin A and TGF-β1 as potential targets for HVOD treatment. Content Type Journal ArticleCategory PharmacodynamicsPages 1-13DOI 10.1007/s00228-011-1209-yAuthors Janka Reimer, Research Center of Pharmacology and Experimental Therapeutics, Department of Pharmacology, Ernst-Moritz-Arndt-University of Greifswald, Greifswald, GermanySandra Bien, Research Center of Pharmacology and Experimental Therapeutics, Department of Pharmacology, Ernst-Moritz-Arndt-University of Greifswald, Greifswald, GermanySabine Ameling, Department of Functional Geno... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5648113 Fri, 27 Jan 2012 17:52:03 +0100 5648113 http://www.medworm.com/index.php?rid=5648115&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2v2230183p303882%2F Conclusion  We developed a prediction basis for mean posaconazole concentrations in AML/MDS patients. Patient weight, presence of diarrhea, and concomitant medication (chemotherapy and pantoprazole) showed significant effects on posaconazole exposure. Corresponding adjustments of the starting dose according to the presence of diarrhea and during the co-administration of chemotherapy or proton-pump inhibitors appear justified before therapeutic drug monitoring results are available. Further investigation of the interaction between different chemotherapeutic regimens and posaconazole is warranted. Content Type Journal ArticleCategory Pharmacokinetics and DispositionPages 1-9DOI 10.1007/s00228-012-1212-yAuthors J. J. Vehreschild, Department I of Internal Medicine, Uni... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5648115 Fri, 27 Jan 2012 17:52:02 +0100 5648115 http://www.medworm.com/index.php?rid=5648114&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr762v47k6uptk033%2F Conclusions  Our findings suggest an association between gynecomastia and statins as a drug class, and the occurrence of this ADR would appear to be more likely with active substances that show an higher potency in inhibiting HMG-CoA reductase enzyme. To date, the safety information provided on the labels of different statin-containing medicines is not standardized. Harmonization of this information would be helpful for both healthcare practitioners and patients. Content Type Journal ArticleCategory Short CommunicationPages 1-5DOI 10.1007/s00228-012-1218-5Authors Giuseppe Roberto, Department of Pharmacology, University of Bologna, Via Irnerio 48, 40126 Bologna, ItalyChiara Biagi, Department of Pharmacology, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5648114 Fri, 27 Jan 2012 17:52:02 +0100 5648114 http://www.medworm.com/index.php?rid=5648116&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fhlr7327044u58286%2F Conclusions  Grapefruit juice significantly increased the plasma concentrations of oral ketamine in healthy volunteers. Dose reductions of ketamine should be considered when using oral ketamine concomitantly with grapefruit juice. Content Type Journal ArticleCategory Pharmacokinetics and DispositionPages 1-8DOI 10.1007/s00228-012-1214-9Authors Marko A. Peltoniemi, Department of Anesthesiology, Intensive Care, Emergency Care and Pain Medicine, University of Turku, P.O. Box 52, Kiinamyllynkatu 4-8, FI-20520 Turku, FinlandTeijo I. Saari, Department of Anesthesiology, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, GermanyNora M. Hagelberg, Department of Anesthesiology, Intensive Care, Emergency Care and Pain Medicine, University of Turku, P.O. Box 52, Kiinam... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5648116 Fri, 27 Jan 2012 17:52:01 +0100 5648116 http://www.medworm.com/index.php?rid=5648117&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp4g6640rh4633203%2F Conclusion  This study demonstrates that CYP2D6 polymorphisms appeared to influence the disposition of lovastatin lactone in these subjects. Content Type Journal ArticleCategory PharmacogeneticsPages 1-7DOI 10.1007/s00228-011-1202-5Authors Ophelia Qi Ping Yin, School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong KongValiant Wah Lun Mak, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong KongMiao Hu, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong KongBenny Siu Pong Fok, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Ho... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5648117 Thu, 26 Jan 2012 16:45:55 +0100 5648117 http://www.medworm.com/index.php?rid=5648118&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe75l232487464142%2F Conclusion  With twice weekly dosing, the need for PK-based dose tailoring of FIX in adult patients appears to be limited. However, monitoring FIX levels should be considered in children, in patients who do not respond satisfactorily to standard dosing, and if treatment is switched from plasma-derived to recombinant FIX. Content Type Journal ArticleCategory Pharmacokinetics and DispositionPages 1-9DOI 10.1007/s00228-012-1211-zAuthors Sven Björkman, Department of Pharmaceutical Biosciences, Uppsala University, Box 591, SE-751 24 Uppsala, SwedenVictor Åhlén, Department of Pharmaceutical Biosciences, Uppsala University, Box 591, SE-751 24 Uppsala, Sweden Journal European Journal of Clinical PharmacologyOnline ISSN 1432-1041Print ISSN 0031-6970 (Source: Europea... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5648118 Thu, 26 Jan 2012 16:45:53 +0100 5648118 http://www.medworm.com/index.php?rid=5638602&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fbu51w4th66487p17%2F Conclusions  In conclusion, our data do not show a pronounced developmental regulation of IMPDH activity in PBMCs in the paediatric population and there is a comparable inhibition of IMPDH activity by MPA in children and adolescents after renal transplantation. Content Type Journal ArticleCategory PharmacodynamicsPages 1-10DOI 10.1007/s00228-011-1203-4Authors A. Rother, Department of Paediatrics I, University Children’s Hospital Heidelberg, Heidelberg, GermanyP. Glander, Department of Nephrology, Charité Universitätsmedizin Berlin, Berlin, GermanyE. Vitt, Department of Paediatric Nephrology, Children’s Hospital of the Ludwig-Maximilians University of Munich, Munich, GermanyD. Czock, Department of Clinical Pharmacology and Pharmacoepidemiology, University Hospita... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5638602 Tue, 24 Jan 2012 18:15:12 +0100 5638602 http://www.medworm.com/index.php?rid=5638603&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F323323p156720766%2F Conclusion  The pharmacokinetics of metformin was influenced by lean body weight on an allometric basis and was related to markers of renal function, age, and serum creatinine in this population of 105 patients. Content Type Journal ArticleCategory Pharmacokinetics and DispositionPages 1-8DOI 10.1007/s00228-011-1207-0Authors Christophe Bardin, Pharmacy-Pharmacology-Toxicology Department, Hôtel-Dieu, AP-HP, 1, Place du Parvis Notre-Dame, 75181 Paris Cédex 04, FranceEstelle Nobecourt, Diabetology Department, Hôtel-Dieu, AP-HP, Paris, FranceEtienne Larger, Diabetology Department, Hôtel-Dieu, AP-HP, Paris, FranceFrançois Chast, Pharmacy-Pharmacology-Toxicology Department, Hôtel-Dieu, AP-HP, 1, Place du Parvis Notre-Dame, 75181 Paris Cédex 04, FranceJean-Marc Treluy... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5638603 Tue, 24 Jan 2012 18:15:11 +0100 5638603 http://www.medworm.com/index.php?rid=5638605&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff714010333280kj8%2F Conclusions  Although drug-resistant partial epilepsy is associated with a higher probability of developing vestibulo-cerebellar AEs, the risk for PGB toxicity does not differ across distinct disorders. Content Type Journal ArticleCategory Clinical TrialPages 1-10DOI 10.1007/s00228-012-1213-xAuthors Gaetano Zaccara, U.O. Neurologia, Azienda Sanitaria di Firenze, Firenze, ItalyPiero Perucca, Montreal Neurological Institute, McGill University, Montreal, Quebec, CanadaPier Franco Gangemi, Anffas Rehabilitation Institute, Firenze, Italy Journal European Journal of Clinical PharmacologyOnline ISSN 1432-1041Print ISSN 0031-6970 (Source: European Journal of Clinical Pharmacology) European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5638605 Tue, 24 Jan 2012 07:20:02 +0100 5638605 http://www.medworm.com/index.php?rid=5638604&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F03434pgrt1880j13%2F Conclusion  Genetic variation in CYP2A6 does not appear to be an important determinant of dexmedetomidine clearance in ICU patients. Content Type Journal ArticleCategory PharmacogeneticsPages 1-6DOI 10.1007/s00228-011-1208-zAuthors Utkarsh Kohli, Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN, USAPratik Pandharipande, Division of Critical Care Medicine, Department of Anaesthesiology, Vanderbilt University, Nashville, TN, USAMordechai Muszkat, Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN, USAGbenga G. Sofowora, Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN, USAEitan A. ... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5638604 Tue, 24 Jan 2012 07:20:02 +0100 5638604 http://www.medworm.com/index.php?rid=5638606&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx396362071635314%2F Conclusions  We found that relevant differences exist between the northern and the southern part of the country, and the heterogeneity among LHUs is higher. The greater use of antibiotics in the southern regions is related to lower HDI and does not seems to be justified by the higher prevalence of infectious diseases. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionPages 1-9DOI 10.1007/s00228-011-1204-3Authors Daniele Piovani, Department of Public Health, Laboratory for Mother and Child Health, “Mario Negri” Institute for Pharmacological Research, Via Giuseppe La Masa 19, 20156 Milan, ItalyAntonio Clavenna, Department of Public Health, Laboratory for Mother and Child Health, “Mario Negri” Institute for Pharmacological Research, Via G... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5638606 Tue, 24 Jan 2012 07:20:01 +0100 5638606 http://www.medworm.com/index.php?rid=5620271&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fbmhrw612g156hlj6%2F Conclusions  This study demonstrates that it may be possible to predict the clearance of CYP1A2 substrates in smoking populations using quantitative estimates of CYP1A2 abundance based on daily cigarette consumption in conjunction with an IVIVE approach. Content Type Journal ArticleCategory Pharmacokinetics and DispositionPages 1-10DOI 10.1007/s00228-011-1189-yAuthors David R. Plowchalk, Clinical Pharmacology, Primary Care BU, Pfizer Inc, 445 Eastern Point Road, MS 8260/2253, Groton, CT 06340, USAKaren Rowland Yeo, Simcyp Limited, Blades Enterprise Centre, John Street, Sheffield, S2 4SU UK Journal European Journal of Clinical PharmacologyOnline ISSN 1432-1041Print ISSN 0031-6970 (Source: European Journal of Clinical Pharmacology) European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5620271 Thu, 19 Jan 2012 06:56:03 +0100 5620271 http://www.medworm.com/index.php?rid=5620272&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fun44u05k612x28r7%2F Conclusion  Prior administration of enoxaparin did not meaningfully affect the PK or PD properties of dabigatran, and the switch from enoxaparin to dabigatran etexilate was well tolerated among the study subjects. These data support the safety of switching patients from enoxaparin to dabigatran etexilate. Content Type Journal ArticleCategory PharmacodynamicsPages 1-10DOI 10.1007/s00228-011-1205-2Authors Andreas Clemens, Department of Global Clinical Development & Medical Affairs, Boehringer Ingelheim Pharma GmbH, Ingelheim am Rhein, GermanyJoanne van Ryn, Department of CardioMetabolic Disease Research, Boehringer Ingelheim Pharma GmbH, Biberach, GermanyRegina Sennewald, Department of Translational Medicine, Boehringer Ingelheim Pharma GmbH, Biberach, GermanyNorio Yam... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5620272 Wed, 18 Jan 2012 06:59:04 +0100 5620272 http://www.medworm.com/index.php?rid=5597949&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F624m338w23w12176%2F Conclusions  To ensure cefoxitin target concentrations during surgery, we recommend that cefoxitin be administered every 1.5 h in patients with a CLCR ≥60 mL/min and every hour if the CLCR is ≥100 mL/min. Administration by continuous infusion preceded by a bolus injection should also be considered. Content Type Journal ArticleCategory Pharmacokinetics and DispositionPages 1-11DOI 10.1007/s00228-011-1206-1Authors Arantxazu Isla, Laboratory of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of the Basque Country, Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, SpainIñaki F. Trocóniz, Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Navarra, Pamplona, SpainIgnacio López de Tejada, Gen... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5597949 Sat, 14 Jan 2012 16:42:11 +0100 5597949 http://www.medworm.com/index.php?rid=5597950&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa126007321q48630%2F Conclusions  Fluoroquinolones are substantially safe antibiotics. Although fluoroquinolone-related hepatic injury occurs infrequently, its consequences can be severe. Patients should also be cautioned to avoid re-exposure to other members of the fluoroquinolone class. Content Type Journal ArticleCategory Review ArticlePages 1-8DOI 10.1007/s00228-011-1201-6Authors Anna Licata, Sezione e U.O.C. di Gastroenterologia, Di.Bi.M.I.S, Università di Palermo, Palermo, ItalyClaudia Randazzo, Sezione e U.O.C. di Gastroenterologia, Di.Bi.M.I.S, Università di Palermo, Palermo, ItalyIlaria Morreale, Sezione di Farmacologia, Dipartimento di Scienze per la promozione della Salute, Università di Palermo, Palermo, ItalyGiuseppe Butera, Sezione e U.O.C. di Gastroenterologia, Di.Bi.M.... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5597950 Fri, 13 Jan 2012 16:49:07 +0100 5597950 http://www.medworm.com/index.php?rid=5582056&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe701167p54531827%2F Conclusions  Anti-EGFR Mabs are effective for both LA and RM HNSCC. In contrast, TKIs were unsuitable for treatment of advanced HNSCC. During anti-EGFR therapy, rash and some gastrointestinal reactions, such as diarrhea and anorexia, should be carefully monitored. Content Type Journal ArticleCategory Clinical TrialPages 1-9DOI 10.1007/s00228-011-1194-1Authors Shoude Zhang, Department of Otorhinolaryngology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000 People’s Republic of ChinaJia Chen, Department of Otorhinolaryngology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000 People’s Republic of ChinaHua Jiang, Department of Otorhinolaryngology, Second Affiliated Hospital, School of Medicine, ... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5582056 Mon, 09 Jan 2012 19:39:45 +0100 5582056 http://www.medworm.com/index.php?rid=5582057&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn707453412051701%2F Content Type Journal ArticleCategory Letter to the EditorsPages 1-2DOI 10.1007/s00228-011-1165-6Authors Roser Porta, Department of Pediatrics—Neonatology, Institut Universitari Dexeus, Universitat Autònoma de Barcelona, C/ Rosselló, 160, 3rd, 2nd, 08036 Barcelona, SpainLara Sánchez, Department of Pediatrics—Neonatology, Institut Universitari Dexeus, Universitat Autònoma de Barcelona, C/ Rosselló, 160, 3rd, 2nd, 08036 Barcelona, SpainMarta Nicolás, Department of Pediatrics—Neonatology, Institut Universitari Dexeus, Universitat Autònoma de Barcelona, C/ Rosselló, 160, 3rd, 2nd, 08036 Barcelona, SpainCarmen García, Pharmacy Department, Institut Universitari Dexeus, Universitat Autònoma de Barcelona, Barcelona, SpainMarta Martínez, Laboratory of the Institut Universitari D... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5582057 Fri, 06 Jan 2012 16:47:50 +0100 5582057 http://www.medworm.com/index.php?rid=5560359&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe7rt1016q5l66381%2F Conclusions  NH residents showed better BP control than CD elderly while receiving less antihypertensive drugs. The prescription of antihypertensives was assumed to be more cost effective in NH. Nevertheless, inappropriate drug use is still high (NH > CD), and there is an extended need for professional medication assessment in both groups of elderly. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionPages 1-9DOI 10.1007/s00228-011-1195-0Authors Sophie Lochner, Institute of Clinical Pharmacology, Medical Faculty, Technical University of Dresden, Fiedlerstrasse 27, D - 01307 Dresden, GermanyWilhelm Kirch, Institute of Clinical Pharmacology, Medical Faculty, Technical University of Dresden, Fiedlerstrasse 27, D - 01307 Dresden, GermanyChri... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5560359 Fri, 30 Dec 2011 07:09:48 +0100 5560359 http://www.medworm.com/index.php?rid=5560360&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6x773770m415n778%2F Conclusions  There is a less than proportional dose-exposure relationship between nilotinib 300 mg and 400 mg twice-daily doses. Blood level testing is unlikely to play an important role in the general management of patients with newly diagnosed CML treated with nilotinib. Content Type Journal ArticleCategory Pharmacokinetics and DispositionPages 1-11DOI 10.1007/s00228-011-1200-7Authors Richard A. Larson, University of Chicago, Chicago, IL, USAOphelia Q. P. Yin, Novartis Pharmaceuticals Corporation, Florham Park, NJ, USAAndreas Hochhaus, Universitätsklinikum Jena, Jena, GermanyGiuseppe Saglio, University of Turin, Orbassano, ItalyRichard E. Clark, Royal Liverpool University Hospital, Liverpool, UKHirohisa Nakamae, Osaka City University, Osaka, JapanNeil J.... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5560360 Fri, 30 Dec 2011 07:09:47 +0100 5560360 http://www.medworm.com/index.php?rid=5560361&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd11t3n2723146181%2F Conclusions  Based on the very pronounced inter- and intra-day variation in AChE activity in RBC, we conclude that the model-based approach is essential for the proof of concept and quantitation of AChE inhibition in human subjects. Content Type Journal ArticleCategory PharmacodynamicsPages 1-7DOI 10.1007/s00228-011-1192-3Authors Seunghoon Han, Department of Pharmacology, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaJongtae Lee, Department of Pharmacology, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaSangil Jeon, Department of Pharmacology, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaTaegon Hong, Department of Pharmacology, College of Medicine, The Catholic Universit... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5560361 Fri, 30 Dec 2011 07:09:46 +0100 5560361 http://www.medworm.com/index.php?rid=5552457&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fyn65q9003740u568%2F Conclusions  Results showed that only 7% of AEs were reported spontaneously by patients, thus underscoring the importance of systematically asking about AEs in PD patients. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionPages 1-9DOI 10.1007/s00228-011-1198-xAuthors Santiago Perez-Lloret, Laboratoire de Pharmacologie Médicale et Clinique, INSERM U 1027 Equipe de PharmacoEpidémiologie, Faculté de Médecine, Université de Toulouse, Toulouse, FranceMaría Verónica Rey, Laboratoire de Pharmacologie Médicale et Clinique, INSERM U 1027 Equipe de PharmacoEpidémiologie, Faculté de Médecine, Université de Toulouse, Toulouse, FranceNelly Fabre, Service de Neurologie et Explorations Fonctionnelles du Système Nerveux, CHU Rangueil, Toulouse, F... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5552457 Wed, 28 Dec 2011 16:44:24 +0100 5552457 http://www.medworm.com/index.php?rid=5552458&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff5h4mh8860t76354%2F Conclusions  These three analytically confirmed cases demonstrate that acute methoxetamine-related toxicity is associated with both “dissociative” and “sympathomimetic” clinical features. The information from these three cases is useful to clinical pharmacologists, not only in managing individuals with acute methoxetamine toxicity but also in advising the appropriate legislative authorities on the risk of acute harm related to methoxetamine use. Further work is needed to determine whether methoxetamine is more “bladder friendly” than ketamine, as has been suggested by those marketing methoxetamine. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionPages 1-4DOI 10.1007/s00228-011-1199-9Authors David M. Wood, Clinical Toxicology, G... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5552458 Wed, 28 Dec 2011 16:44:23 +0100 5552458 http://www.medworm.com/index.php?rid=5552460&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fwq4471384246r245%2F Abstract  The p38 mitogen-activated protein kinases (p38s) are Ser/Thr kinases that are activated as a result of cellular stresses and various pathological conditions, including myocardial ischemia/reperfusion. p38 activation has been shown to accentuate myocardial injury and impair cardiac function. Inhibition of p38 activation and its activity has been proposed to be cardioprotective by slowing the rate of myocardial damage and improving cardiac function. The growing body of evidence on the use of p38 inhibitors as therapeutic means for responding to heart problems is controversial, since both beneficial as well as a lack of protective effects on the heart have been reported. In this review, the outcomes from studies investigating the effect of p38 inhibitors on the heart... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5552460 Wed, 28 Dec 2011 16:44:22 +0100 5552460 http://www.medworm.com/index.php?rid=5552459&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe6632816r5112052%2F Content Type Journal ArticleCategory Letter to the EditorsPages 1-4DOI 10.1007/s00228-011-1191-4Authors A. Grasland, Department of Internal Medicine, Louis Mourier Hospital, APHP, University Paris VII, 178 rue des Renouillers, 92700 Colombes, Paris, FranceR. Sterpu, Department of Internal Medicine, Louis Mourier Hospital, APHP, University Paris VII, 178 rue des Renouillers, 92700 Colombes, Paris, FranceS. Boussoukaya, Department of Gastroenterology, Louis Mourier Hospital, APHP, University Paris VII, 178 rue des Renouillers, 92700 Colombes, Paris, FranceI. Mahe, Department of Internal Medicine, Louis Mourier Hospital, APHP, University Paris VII, 178 rue des Renouillers, 92700 Colombes, Paris, France Journal European Journal of Clinical PharmacologyOnline ISSN 1432-1041Print ISSN... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5552459 Wed, 28 Dec 2011 16:44:22 +0100 5552459 http://www.medworm.com/index.php?rid=5552461&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj30547835p6812x2%2F Content Type Journal ArticleCategory Letter to the EditorsPages 1-2DOI 10.1007/s00228-011-1196-zAuthors Merja Kokki, Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, School of Medicine, University of Eastern Finland, PO Box 1777, FI-70211 Kuopio, FinlandMohamed Ali, Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, School of Medicine, University of Eastern Finland, PO Box 1777, FI-70211 Kuopio, FinlandMatti Turunen, Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, School of Medicine, University of Eastern Finland, PO Box 1777, FI-70211 Kuopio, FinlandHannu Kokki, Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, School of Medicine, University of Eastern Finland, PO Box 1777... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5552461 Wed, 28 Dec 2011 16:44:16 +0100 5552461 http://www.medworm.com/index.php?rid=5552462&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fvl5891h56463w408%2F Content Type Journal ArticleCategory Letter to the EditorsPages 1-3DOI 10.1007/s00228-011-1179-0Authors W. J. Comuth, Department of Cardiology, University Medical Center, Utrecht, the NetherlandsJ. A. Comuth, Department of Pharmacology, Meander Medical Center, Amersfoort, the NetherlandsR. N. W. Hauer, Department of Cardiology, University Medical Center, Utrecht, the NetherlandsM. M. Malingré, Department of Pharmacology, Meander Medical Center, Amersfoort, the Netherlands Journal European Journal of Clinical PharmacologyOnline ISSN 1432-1041Print ISSN 0031-6970 (Source: European Journal of Clinical Pharmacology) European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5552462 Tue, 27 Dec 2011 17:01:13 +0100 5552462 http://www.medworm.com/index.php?rid=5544711&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft313g72j118v9425%2F Conclusions  This study shows that a woman’s personality traits are associated with use of medications, cigarettes, and alcohol during pregnancy. This knowledge could be of clinical importance to health care personnel providing prenatal care. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionPages 1-7DOI 10.1007/s00228-011-1197-yAuthors Eivind Ystrom, Division of Mental Health, Norwegian Institute of Public Health, PO Box 4404 Nydalen, 0403 Oslo, NorwayMargarete E. Vollrath, Division of Mental Health, Norwegian Institute of Public Health, PO Box 4404 Nydalen, 0403 Oslo, NorwayHedvig Nordeng, Division of Mental Health, Norwegian Institute of Public Health, PO Box 4404 Nydalen, 0403 Oslo, Norway Journal European Journal of Clinical Pharm... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5544711 Wed, 21 Dec 2011 20:06:37 +0100 5544711 http://www.medworm.com/index.php?rid=5544712&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F121212797r7112h4%2F Conclusion  EGb 761® has no relevant effect on the in vivo activity of the major CYP enzymes in humans and therefore has no relevant potential to cause respective metabolic drug–drug interactions. Content Type Journal ArticleCategory Clinical TrialPages 1-8DOI 10.1007/s00228-011-1174-5Authors G. Zadoyan, Department of Pharmacology Clinical Pharmacology Unit, University of Cologne, Gleueler Str. 24, 50931 Cologne, GermanyD. Rokitta, Department of Pharmacology Clinical Pharmacology Unit, University of Cologne, Gleueler Str. 24, 50931 Cologne, GermanyS. Klement, Dr. Willmar Schwabe GmbH & Co. KG, Karlsruhe, GermanyA. Dienel, Dr. Willmar Schwabe GmbH & Co. KG, Karlsruhe, GermanyR. Hoerr, Dr. Willmar Schwabe GmbH & Co. KG, Karlsruhe, GermanyT. Gramatté, Drug Developmen... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5544712 Wed, 21 Dec 2011 20:06:36 +0100 5544712 http://www.medworm.com/index.php?rid=5544713&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg7754668871h57gk%2F Conclusion  Efforts to reduce the use of BZD/Zs in nursing homes should concentrate on insomnia, with interventions aimed at reducing too high prevalence of chronic use and too high daily dosages in this indication. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionPages 1-12DOI 10.1007/s00228-011-1188-zAuthors Jolyce Bourgeois, Heymans Institute of Pharmacology, Ghent University, De Pintelaan 185 (1 blok B), 9000 Ghent, BelgiumMonique M. Elseviers, Heymans Institute of Pharmacology, Ghent University, De Pintelaan 185 (1 blok B), 9000 Ghent, BelgiumMajda Azermai, Heymans Institute of Pharmacology, Ghent University, De Pintelaan 185 (1 blok B), 9000 Ghent, BelgiumLuc Van Bortel, Heymans Institute of Pharmacology, Ghent University, De Pintelaan 1... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5544713 Wed, 21 Dec 2011 20:06:35 +0100 5544713 http://www.medworm.com/index.php?rid=5538210&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl7763p3u50034016%2F Conclusions  Our study confirms known ITP risks for glycoprotein IIb/IIIa receptor antagonists and sulphonamides and generates signals for several other drugs and vaccines. New onset of ITP should not only direct attention to drugs as possible aetiological agents, but also to vaccines that are known to cause autoimmune phenomena. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionPages 1-12DOI 10.1007/s00228-011-1184-3Authors Edeltraut Garbe, Centre of Clinical Pharmacology and Toxicology, Charité–Universitätsmedizin Berlin, Berlin, GermanyFrank Andersohn, Institute for Social Medicine, Epidemiology and Health Economy, Charité–Universitätsmedizin Berlin, Berlin, GermanyElisabeth Bronder, Centre of Clinical Pharmacology and Toxicology, C... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5538210 Tue, 20 Dec 2011 16:46:52 +0100 5538210 http://www.medworm.com/index.php?rid=5524994&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8546403543314655%2F Conclusions  A generalized estimating equation model analysis showed that alopecia and hyperlipidemia were associated with dose-adjusted level of tacrolimus (p < 0.001). Genotype of CYP3A5 variants along with significant clinical covariates may be useful in individualizing tacrolimus therapy in kidney transplantation patients. Content Type Journal ArticleCategory PharmacogeneticsPages 1-13DOI 10.1007/s00228-011-1182-5Authors In-Wha Kim, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 151-742 KoreaYoo Jin Moon, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 151-742 KoreaEunhee Ji, College of Pharmacy ... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5524994 Mon, 19 Dec 2011 16:53:07 +0100 5524994 http://www.medworm.com/index.php?rid=5515594&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk830276r56001142%2F Conclusion  Although the bioavailability of sitagliptin was increased by 54% when co-administered with gemfibrozil, this interaction may not have any clinical significance as sitagliptin has a wide therapeutic index. Hence, in clinical practice, sitagliptin as 100 mg tablets and gemfibrozil as 600 mg tablets may be co-prescribed without much threat of sitagliptin toxicity. However, these results may not hold if the dose of sitagliptin is increased or if is co-prescribed with other antidiabetic drugs and/or cytochrome P450 2C8/human organic anion transporter-3 inhibitors. Further studies are needed to confirm these results in patients. Content Type Journal ArticleCategory Pharmacokinetics and DispositionPages 1-6DOI 10.1007/s00228-011-1177-2Authors Arun K.... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5515594 Thu, 15 Dec 2011 16:50:17 +0100 5515594 http://www.medworm.com/index.php?rid=5515595&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa85j644n1588w2t4%2F Conclusions  No pharmacokinetic drug-drug interaction was demonstrated between venlafaxine XR and indinavir or between desvenlafaxine XR and indinvair. The lack of interaction could be due to the venlafaxine and desvenlafaxine extended-release formulation. Content Type Journal ArticleCategory Pharmacokinetics and DispositionPages 1-7DOI 10.1007/s00228-011-1180-7Authors Michael W. Jann, Mercer University College of Pharmacy and Health Sciences, 3001 Mercer University Dr., Atlanta, GA 30341, USAVicky Spratlin, Mercer University College of Pharmacy and Health Sciences, 3001 Mercer University Dr., Atlanta, GA 30341, USAKathryn Momary, Mercer University College of Pharmacy and Health Sciences, 3001 Mercer University Dr., Atlanta, GA 30341, USAHailing Zhang, Mercer Universi... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5515595 Thu, 15 Dec 2011 16:50:16 +0100 5515595 http://www.medworm.com/index.php?rid=5515597&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp005591r233u6rl3%2F Conclusions  No statistically significant associations between the specific polymorphisms analysed and axitinib plasma exposure were observed, suggesting that genotype- or inferred phenotype-based adjustment of axitinib dose in individual subjects is not warranted. Content Type Journal ArticleCategory PharmacogeneticsPages 1-11DOI 10.1007/s00228-011-1171-8Authors Meghan Brennan, Pfizer Research Center of Emphasis for DNA and Biofluids—Biobank, Groton, CT, USAJ. Andrew Williams, Translational Oncology, Pfizer Inc, 10777 Science Center Drive, La Jolla, CA 92121, USAYing Chen, Clinical Pharmacology, Pfizer Inc, 10777 Science Center Drive, La Jolla, CA 92121, USAMichael Tortorici, Clinical Pharmacology, Pfizer Inc, 10777 Science Center Drive, La Jolla, CA 92121, USAYazd... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5515597 Wed, 14 Dec 2011 16:41:53 +0100 5515597 http://www.medworm.com/index.php?rid=5515596&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F868r21m723242w83%2F Content Type Journal ArticleCategory Letter to the EditorsPages 1-2DOI 10.1007/s00228-011-1190-5Authors Luca Mascitelli, Comando Brigata Alpina “Julia”, Medical Service, 8 Via S. Agostino, Udine, 33100 ItalyWilliam B. Grant, Sunlight, Nutrition, and Health Research Center (SUNARC), P.O. Box 641603, San Francisco, CA 94164-1603, USAMark R. Goldstein, NCH Healthcare Group, 1845 Veterans Park Drive, Suite 110, Naples, FL 34109, USA Journal European Journal of Clinical PharmacologyOnline ISSN 1432-1041Print ISSN 0031-6970 (Source: European Journal of Clinical Pharmacology) European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5515596 Wed, 14 Dec 2011 16:41:53 +0100 5515596 http://www.medworm.com/index.php?rid=5515598&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy1x6376578987777%2F Conclusion  The level of CAM use by Scottish breast cancer patients is similar to that reported from other countries, although there are marked differences in the type, nature and frequency of specific CAM therapies. Higher patient education level and use by family and friends were significantly associated with CAM use. The high level of use of potentially disease modifying or interacting herb supplements may be of concern. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionPages 1-9DOI 10.1007/s00228-011-1181-6Authors J. S. McLay, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, AB25 2ZG UKD. Stewart, Robert Gordon University, Aberdeen, UKJ. George, Robert Gordon University, Aberdeen, UKC. Rore, NHS Grampian, Aberdeen, U... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5515598 Tue, 13 Dec 2011 17:05:34 +0100 5515598 http://www.medworm.com/index.php?rid=5515600&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn2003734703p48h6%2F Content Type Journal ArticleCategory EditorialPages 1-2DOI 10.1007/s00228-011-1186-1Authors E. Ernst, Complementary Medicine, Peninsula Medical School, University of Exeter, Veysey Building, Salmon Pool Lane, Exeter, EX2 4SG UK Journal European Journal of Clinical PharmacologyOnline ISSN 1432-1041Print ISSN 0031-6970 (Source: European Journal of Clinical Pharmacology) European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5515600 Tue, 13 Dec 2011 17:05:33 +0100 5515600 http://www.medworm.com/index.php?rid=5515599&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff320388408223157%2F Conclusion  To reduce the risk of ADRs in children, clinicians and pharmacists should aim to minimise polypharmacy and be aware of higher ADR risks associated with some drug groups. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionPages 1-10DOI 10.1007/s00228-011-1183-4Authors Asia N. Rashed, Centre for Paediatric Pharmacy Research, The School of Pharmacy, University of London, 29-39 Brunswick Square, London, WC1N 1AX UKIan C. K. Wong, Centre for Paediatric Pharmacy Research, The School of Pharmacy, University of London, 29-39 Brunswick Square, London, WC1N 1AX UKNoel Cranswick, Pharmacology Research Unit, Royal Children’s Hospital, Flemington Road, Parkville, VIC 3052, AustraliaStephen Tomlin, Evelina Children’s Hospital, Guy’s & St. Th... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5515599 Tue, 13 Dec 2011 17:05:33 +0100 5515599 http://www.medworm.com/index.php?rid=5515601&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6tn602637665w146%2F Content Type Journal ArticleCategory Letter to the EditorsPages 1-2DOI 10.1007/s00228-011-1185-2Authors Chakradhara Rao S. Uppugunduri, Department of Pediatrics, Onco-hematology Unit, Geneva University Hospitals, Rue Willy-Donzé 6, 1211 Genève 14, SwitzerlandMarc Ansari, Department of Pediatrics, Onco-hematology Unit, Geneva University Hospitals, Rue Willy-Donzé 6, 1211 Genève 14, Switzerland Journal European Journal of Clinical PharmacologyOnline ISSN 1432-1041Print ISSN 0031-6970 (Source: European Journal of Clinical Pharmacology) European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5515601 Tue, 13 Dec 2011 17:05:31 +0100 5515601 http://www.medworm.com/index.php?rid=5515602&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd4g7300616332rl7%2F Content Type Journal ArticleCategory Letter to the EditorsPages 1-2DOI 10.1007/s00228-011-1187-0Authors Patchva Dorababu, Department of Medical Oncology, Nizam’s Institute of Medical Sciences (NIMS), Hyderabad, IndiaShaik Mohammad Naushad, Department of Clinical Pharmacology and Therapeutics, Nizam’s Institute of Medical Sciences (NIMS), Hyderabad, IndiaVijay Kumar Kutala, Department of Clinical Pharmacology and Therapeutics, Nizam’s Institute of Medical Sciences (NIMS), Hyderabad, IndiaRaghunadharao Digumarti, Department of Medical Oncology, Nizam’s Institute of Medical Sciences (NIMS), Hyderabad, India Journal European Journal of Clinical PharmacologyOnline ISSN 1432-1041Print ISSN 0031-6970 (Source: European Journal of Clinical Pharmacology) European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5515602 Tue, 13 Dec 2011 17:05:30 +0100 5515602 http://www.medworm.com/index.php?rid=5515603&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F55k36073hj43463l%2F Conclusion  Off-label drug utilization is essential in oncology when based on evidence. However, off-label drugs must be prescribed in accordance with existing national laws and only when the potential benefit outweighs the potential toxic effects. Content Type Journal ArticleCategory Review ArticlePages 1-8DOI 10.1007/s00228-011-1173-6Authors Rosa Lerose, Hospital Pharmacy, I.R.C.C.S. Centro di Riferimento Oncologico di Basilicata, Via Padre Pio 1, 85028 Rionero in Vulture, PZ, ItalyPellegrino Musto, Department of Onco-Hematology, I.R.C.C.S. Centro di Riferimento Oncologico di Basilicata, Rionero in Vulture, PZ, ItalyMichele Aieta, Department of Onco-Hematology, I.R.C.C.S. Centro di Riferimento Oncologico di Basilicata, Rionero in Vulture, PZ, ItalyCarla Papa, Hospit... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5515603 Tue, 13 Dec 2011 17:05:29 +0100 5515603 http://www.medworm.com/index.php?rid=5495005&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv286qj66839601l6%2F Conclusions  The correlation between CYP3A4 activity (assessed by alprazolam 4-hydroxylation) and CRP level suggests that inflammation may downregulate CYP3A4 activity. If confirmed, this could have major implications for drug dosing in persistently inflamed patients. Content Type Journal ArticleCategory Special ArticlePages 1-7DOI 10.1007/s00228-011-1163-8Authors Hadi Molanaei, Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, SwedenPeter Stenvinkel, Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, SwedenAbdul Rashid Qureshi, Divisions of Renal Medicine and Baxter Novum, Department of C... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5495005 Thu, 08 Dec 2011 18:25:03 +0100 5495005 http://www.medworm.com/index.php?rid=5487019&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F11182x3670196177%2F Conclusions  The results of this study are in favour of the integration of an automated signal detection tool to complement the current pharmacovigilance activities. The Anatomic Therapeutic Chemical for drug classification poses difficulties in many situations; the international proprietary name might be more efficient. The variability observed in the time needed for analysis suggests that a standardised methodology should be employed. Overall, the findings of this prospective study will contribute to refining the signal management procedure to be implemented in the future. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionPages 1-7DOI 10.1007/s00228-011-1178-1Authors Véronique Pizzoglio, AFSSAPS, 93285 Saint-Denis, Paris, FranceIsmaïl Ah... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5487019 Mon, 05 Dec 2011 17:40:01 +0100 5487019 http://www.medworm.com/index.php?rid=5487020&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8878247lj62hr19h%2F Conclusions  In this study, the pharmacokinetic profile of sirolimus in hepatic allograft patients was consistent with that of renal transplantation recipients. With the exception of pneumonia, no correlation was observed between Cmin,TN and the occurrence of adverse events of interest. Content Type Journal ArticleCategory PharmacodynamicsPages 1-9DOI 10.1007/s00228-011-1172-7Authors Jürg Reichen, University Clinic for Visceral Surgery and Medicine, University Hospital Inselspital, Berne, SwitzerlandFelix Stickel, University Clinic for Visceral Surgery and Medicine, University Hospital Inselspital, Berne, SwitzerlandIndranil Bhattacharya, Pfizer Inc, 500 Arcola Road, Collegeville, PA 19426, USAKyle Matschke, Pfizer Inc, 500 Arcola Road, Collegeville, PA 19426, USAEri... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5487020 Mon, 05 Dec 2011 17:40:00 +0100 5487020 http://www.medworm.com/index.php?rid=5476731&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk8w413p667853778%2F Conclusions  In our study, AAPs but not SSRIs were associated with increased prevalence of LUTS among women only. Further prospective research is needed to determine time sequence and cause and effect. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionPages 1-9DOI 10.1007/s00228-011-1170-9Authors Susan A. Hall, New England Research Institutes, 9 Galen St., Watertown, MA 02472, USANancy N. Maserejian, New England Research Institutes, 9 Galen St., Watertown, MA 02472, USACarol L. Link, New England Research Institutes, 9 Galen St., Watertown, MA 02472, USAWilliam D. Steers, University of Virginia School of Medicine, Charlottesville, VA 22908, USAJohn B. McKinlay, New England Research Institutes, 9 Galen St., Watertown, MA 02472, USA Journal... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5476731 Sat, 03 Dec 2011 16:50:19 +0100 5476731 http://www.medworm.com/index.php?rid=5476732&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4j733734v35381jk%2F Content Type Journal ArticleCategory Point of ViewPages 1-3DOI 10.1007/s00228-011-1175-4Authors Vittorio Bertele’, Mario Negri Institute for Pharmacological Research, Via La Masa 19, 20156 Milan, ItalyRita Banzi, Mario Negri Institute for Pharmacological Research, Via La Masa 19, 20156 Milan, ItalyChristian Gluud, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, DenmarkSilvio Garattini, Mario Negri Institute for Pharmacological Research, Via La Masa 19, 20156 Milan, Italy Journal European Journal of Clinical PharmacologyOnline ISSN 1432-1041Print ISSN 0031-6970 (Source: European Journal of Clinical Pharmacology) European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5476732 Thu, 01 Dec 2011 19:31:17 +0100 5476732 http://www.medworm.com/index.php?rid=5469104&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff44270461407n568%2F We report here one rare adverse effect, i.e., intrahepatic cholestasis related to lenalidomide, in two patients out of a total of 65 newly diagnosed cases of multiple myeloma receiving MPL regimen in our series. As the use of lenalidomide will increase in the future for multiple myeloma and other diseases, clinicians should be aware of this entity. Content Type Journal ArticleCategory Short CommunicationPages 1-4DOI 10.1007/s00228-011-1152-yAuthors Rabindra Kumar Jena, Department of Clinical Hematology, S.C.B. Medical College and Hospital, Cuttack, 753007 Odisha, IndiaTrupti Rekha Swain, Pharmacology Department, Clinical Pharmacology Unit, S.C.B. Medical College and Hospital, Cuttack, 753007 Odisha, IndiaSandeep Sadashivrao Kansurkar, Medicine Department, S.C.B. Medical College a... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5469104 Wed, 30 Nov 2011 04:53:26 +0100 5469104 http://www.medworm.com/index.php?rid=5469105&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn0240h483217g253%2F Conclusion  The PCL approach may improve patients’ understanding and use of their medication regimen. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionPages 1-6DOI 10.1007/s00228-011-1169-2Authors Laura J. Sahm, School of Pharmacy, Pharmaceutical Care Research Group, University College Cork, Cavanagh Pharmacy Building, College Rd, Cork, IrelandM. S. Wolf, Health Literacy and Learning Program, Division of General Internal Medicine, Northwestern University, 750 N. Lake Shore Drive, 10th Floor, Chicago, IL 60611, USAL. M. Curtis, Health Literacy and Learning Program, Division of General Internal Medicine, Northwestern University, 750 N. Lake Shore Drive, 10th Floor, Chicago, IL 60611, USAR. Behan, School of Pharmacy, University College Cork, Cavan... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5469105 Wed, 30 Nov 2011 04:53:25 +0100 5469105 http://www.medworm.com/index.php?rid=5457948&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj3m427u2045065k0%2F Conclusions  Grapefruit juice decreases exposure of aliskiren partially via inhibition of intestinal OATP1A2. Content Type Journal ArticleCategory Pharmacokinetics and DispositionPages 1-12DOI 10.1007/s00228-011-1167-4Authors Sam Rebello, Translational Sciences, Novartis Institute for Biomedical Research, One Health Plaza, Bldg 438-3410, East Hanover, NJ 07936-1080, USASally Zhao, Translational Sciences, Novartis Institute for Biomedical Research, One Health Plaza, Bldg 438-3410, East Hanover, NJ 07936-1080, USASam Hariry, Translational Sciences, Novartis Institute for Biomedical Research, One Health Plaza, Bldg 438-3410, East Hanover, NJ 07936-1080, USAMarion Dahlke, Translational Sciences, Novartis Institute for Biomedical Research, One Health Plaza, Bldg 438-3410, Eas... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5457948 Mon, 28 Nov 2011 16:59:47 +0100 5457948 http://www.medworm.com/index.php?rid=5449869&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb088770738052448%2F Conclusions  The results of this study suggest that antidepressant use is associated with an increased risk of diabetes. This association was observed with use of TCAs, SNRIs, SSRIs, and “other” antidepressants. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionPages 1-8DOI 10.1007/s00228-011-1168-3Authors S. Khoza, Department of Clinical Pharmacology, College of Health Sciences, University of Zimbabwe, PO Box A 178, Avondale, Harare, ZimbabweJ. C. Barner, College of Pharmacy, The University of Texas at Austin, Austin, TX, USAT. M. Bohman, School of Social Work, The University of Texas at Austin, Austin, TX, USAK. Rascati, College of Pharmacy, The University of Texas at Austin, Austin, TX, USAK. Lawson, College of Pharmacy, The University o... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5449869 Fri, 25 Nov 2011 17:57:51 +0100 5449869 http://www.medworm.com/index.php?rid=5449870&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Flq232760726022l1%2F Conclusion  We conclude that the use of adaptive study design saves time in early phase research programs. This is achieved by abolishing the need for substantial amendments or by mitigating their impact on timelines and by using adaptive scheduling efficiencies. Content Type Journal ArticleCategory Clinical TrialPages 1-9DOI 10.1007/s00228-011-1176-3Authors U. Lorch, Richmond Pharmacology Ltd, St George’s University of London, Cranmer Terrace, Tooting, London, SW17 0RE, UKK. Berelowitz, Richmond Pharmacology Ltd, St George’s University of London, Cranmer Terrace, Tooting, London, SW17 0RE, UKC. Ozen, Richmond Pharmacology Ltd, St George’s University of London, Cranmer Terrace, Tooting, London, SW17 0RE, UKA. Naseem, Richmond Pharmacology Ltd, St George’s Univ... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5449870 Thu, 24 Nov 2011 17:49:51 +0100 5449870 http://www.medworm.com/index.php?rid=5449871&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu12p636315h32311%2F Conclusion  Around 40% of ADRs reported with SRIs were related to DDIs. Most of these occurred after association with psychotropics, antithrombotics, or diuretics, especially in the elderly. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionPages 1-9DOI 10.1007/s00228-011-1156-7Authors Francois Montastruc, Laboratoire de Pharmacologie Médicale et Clinique, UMR-INSERM U1027, Equipe de Pharmacoépidémiologie, Faculté de Médecine, Université de Toulouse, 37 allées Jules-Guesde, 31000 Toulouse, FranceAgnès Sommet, Laboratoire de Pharmacologie Médicale et Clinique, UMR-INSERM U1027, Equipe de Pharmacoépidémiologie, Faculté de Médecine, Université de Toulouse, 37 allées Jules-Guesde, 31000 Toulouse, FranceEmmanuelle Bondon-Guitton, Labo... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5449871 Thu, 24 Nov 2011 17:49:50 +0100 5449871 http://www.medworm.com/index.php?rid=5449872&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh78wj73p48482348%2F Conclusions  Our data demonstrate that increasing rabeprazole dose up to 40 mg once daily results in an increasing pharmacodynamic effect, which is most apparent for the control of nocturnal gastric acid secretion. Content Type Journal ArticleCategory PharmacodynamicsPages 1-10DOI 10.1007/s00228-011-1164-7Authors Seiichi Hayato, Eisai Product Creation Systems, Eisai Co., Ltd., 4-6-10 Koishikawa, Bunkyo-ku, Tokyo 112-8088, JapanSetsuo Hasegawa, Sekino Clinical Pharmacology Clinic, 3-28-3 Ikebukuro, Toshima-ku, Tokyo 171-0014, JapanSeiichiro Hojo, Eisai Product Creation Systems, Eisai Co., Ltd., 4-6-10 Koishikawa, Bunkyo-ku, Tokyo 112-8088, JapanHiroki Okawa, Eisai Product Creation Systems, Eisai Co., Ltd., 4-6-10 Koishikawa, Bunkyo-ku, Tokyo 112-8088, JapanHiroaki... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5449872 Tue, 22 Nov 2011 17:58:15 +0100 5449872 http://www.medworm.com/index.php?rid=5449874&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg4724757lpwm2w53%2F Conclusion  Unexpectedly, concomitant rifampicin-containing tuberculosis treatment reduced apparent EFV clearance with a corresponding increase in EFV exposure. While the reasons for this interaction require further investigation, cytochrome P450 2B6 polymorphisms in the population studied may provide some explanation. Content Type Journal ArticleCategory Pharmacokinetics and DispositionPages 1-7DOI 10.1007/s00228-011-1166-5Authors Tanuja N. Gengiah, Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South AfricaNicholas H. G. Holford, Department of Pharmacology & Clinical Pharmacology, University of Auckland, Auckland, New ZealandJulia H. Botha, Department of Therapeutics and Medicines Management, University of ... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5449874 Tue, 22 Nov 2011 17:58:14 +0100 5449874 http://www.medworm.com/index.php?rid=5449873&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9864tv0121526876%2F Conclusions   Fluconazole, but not itraconazole, increases zafirlukast plasma concentrations, strongly suggesting that CYP2C9 but not CYP3A4 participates in zafirlukast metabolism in humans. Content Type Journal ArticleCategory Pharmacokinetics and DispositionPages 1-8DOI 10.1007/s00228-011-1158-5Authors Tiina Karonen, Department of Clinical Pharmacology, University of Helsinki and HUSLAB, Helsinki University Central Hospital, P.O. Box 705, FI-00029 Helsinki, FinlandJouko Laitila, Department of Clinical Pharmacology, University of Helsinki and HUSLAB, Helsinki University Central Hospital, P.O. Box 705, FI-00029 Helsinki, FinlandMikko Niemi, Department of Clinical Pharmacology, University of Helsinki and HUSLAB, Helsinki University Central Hospital, P.O. Box 705, FI-0... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5449873 Tue, 22 Nov 2011 17:58:14 +0100 5449873 http://www.medworm.com/index.php?rid=5441200&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm64223l1ngg38l48%2F Conclusion  This review provides an overview on the properties of macrolides (erythromycin, clarithromycin, roxithromycin, azithromycin), their efficacy in various respiratory diseases and their adverse effects. Content Type Journal ArticleCategory Review ArticlePages 1-25DOI 10.1007/s00228-011-1161-xAuthors P. Zarogoulidis, Pulmonary Department, “G. Papanikolaou” Hospital, Aristotle University of Thessaloniki, Thessaloniki, 57010 GreeceN. Papanas, Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, GreeceI. Kioumis, Pulmonary Department, “G. Papanikolaou” Hospital, Aristotle University of Thessaloniki, Thessaloniki, 57010 GreeceE. Chatzaki, Laboratory of Pharmacology, Medical School, Democritus University of Thrace, Alexa... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5441200 Mon, 21 Nov 2011 18:03:38 +0100 5441200 http://www.medworm.com/index.php?rid=5441202&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd5285688n12521kj%2F Conclusions  Our results demonstrate the importance of the interaction among genetic and clinical factors in conditioning tacrolimus disposition, with corticosteroid weight-based dose being the only modifiable risk factor for tacrolimus requirement. As the tacrolimus dosing requirement increases with increasing tacrolimus clearance through concomitant steroid use, undesirable changes in tacrolimus levels may occur when steroid doses are tapered, predominantly in slow metabolizers. This often neglected drug interaction has to be monitored to optimize tacrolimus exposure in kidney transplant patients. Content Type Journal ArticleCategory Pharmacokinetics and DispositionPages 1-10DOI 10.1007/s00228-011-1150-0Authors P. Stratta, Department of Clinical and Experimental ... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5441202 Sat, 19 Nov 2011 16:53:54 +0100 5441202 http://www.medworm.com/index.php?rid=5441201&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm653427500413054%2F Conclusion  In patients with cirrhosis, a 2- to 3-h tezosentan infusion was safe and well tolerated but did not change the HVPG. Tezosentan infusion had no influence on the extraction ratio and plasma clearance of ICG and did not change HBF. Content Type Journal ArticleCategory Clinical TrialPages 1-9DOI 10.1007/s00228-011-1157-6Authors Didier Lebrec, Unité 773, Centre de Recherche Biomédicale Bichat-Beaujon CRB3, INSERM, Paris, FranceJaime Bosch, Hepatic Hemodynamic Laboratory, Liver Unit Hospital IDIBAP and Ciberehd, Barcelona, SpainRajiv Jalan, Institute of Hepatology, University College London Medical School, London, UKFrancis J. Dudley, Alfred Hospital and Baker Research Institute, Prahran, Victoria, AustraliaRada Jessic, Institute for Digestive Diseases, Clini... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5441201 Sat, 19 Nov 2011 16:53:54 +0100 5441201 http://www.medworm.com/index.php?rid=5422305&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fcl66367824u21q81%2F Conclusion  Only patients with a GFR >60 ml/min can be safely treated with enoxaparin. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionPages 1-9DOI 10.1007/s00228-011-1149-6Authors Philipp Hoffmann, Nephrology, Medical Clinic, Ulm University, Ulm, GermanyFrieder Keller, Nephrology, Medical Clinic, Ulm University, Ulm, Germany Journal European Journal of Clinical PharmacologyOnline ISSN 1432-1041Print ISSN 0031-6970 (Source: European Journal of Clinical Pharmacology) European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5422305 Wed, 16 Nov 2011 18:00:35 +0100 5422305 http://www.medworm.com/index.php?rid=5422306&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fcut061m557265001%2F Conclusions  Our meta-analysis indicates that the superiority of ESAs over conventional therapy in patients with acute STEMI is limited using current procedures. However, there is evidence to suggest that the timing and dosing of ESA administration may be optimized. Moreover, the long-term cardio-protective effect of ESAs in this patient population may be beneficial and worth exploring. Content Type Journal ArticleCategory Review ArticlePages 1-9DOI 10.1007/s00228-011-1160-yAuthors Juan Li, Department of Hematology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, ChinaHuiyan Xu, Department of Ophthalmology, Wuxi No. 2 People’s Hospital, Wuxi, ChinaQian Gao, Center of Translational Medicine, Nanjing University Medical School, 22 Han... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5422306 Tue, 15 Nov 2011 16:49:06 +0100 5422306 http://www.medworm.com/index.php?rid=5408402&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe6672532615878hr%2F Conclusions  Our data suggest that only 1% of subjects of this Ecuadorian population were PMs and that none were phenotypically ultrarapid metabolizers, which is in agreement with previous findings in other Amerindian populations. Content Type Journal ArticleCategory PharmacogeneticsPages 1-8DOI 10.1007/s00228-011-1147-8Authors Pedro Dorado, CICAB Clinical Research Centre, Extremadura University Hospital and Medical School, Badajoz, SpainNatalia Heras, Biomedical Centre, Central University of Ecuador, Quito, EcuadorEsther Machín, CICAB Clinical Research Centre, Extremadura University Hospital and Medical School, Badajoz, SpainFrancisco Hernández, School of Medicine, Universidad Estatal de Guayaquil, Guayaquil, EcuadorEnrique Teran, Biomedical Centre, Central Univers... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5408402 Mon, 14 Nov 2011 16:56:23 +0100 5408402 http://www.medworm.com/index.php?rid=5408403&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd60172u4157g86nl%2F Conclusion  Our findings indicate that the purported benefit of statins in preventing pneumonia is inconsistent, and of low magnitude, with upper bounds of the confidence interval being close to null. In view of the substantial statistical and clinical heterogeneity in the dataset, there is no convincing evidence to support the therapeutic application of statins for reducing the risk of pneumonia. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionPages 1-9DOI 10.1007/s00228-011-1159-4Authors Chun Shing Kwok, School of Medicine, University of East Anglia, Norwich, NR4 7TJ, UKJessica Ka-Yan Yeong, School of Medicine, University of East Anglia, Norwich, NR4 7TJ, UKRichard M. Turner, Norfolk and Norwich University Hospital, Colney Lane, Norwich, ... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5408403 Mon, 14 Nov 2011 16:56:22 +0100 5408403 http://www.medworm.com/index.php?rid=5408404&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr42316p72506032g%2F Conclusions  There is a need for greater focus on determining the most effective and accurate way of using linked administrative data to investigate outcomes following medication use during pregnancy in an effort to minimise potential biases. Content Type Journal ArticleCategory Review ArticlePages 1-9DOI 10.1007/s00228-011-1154-9Authors Luke E. Grzeskowiak, Quality Use of Medicines and Pharmacy Research Centre, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, GPO Box 2471, Adelaide, SA 5001, AustraliaAndrew L. Gilbert, Quality Use of Medicines and Pharmacy Research Centre, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, GPO Box 2471, Adelaide, SA... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5408404 Sat, 12 Nov 2011 16:53:51 +0100 5408404 http://www.medworm.com/index.php?rid=5408405&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy34n468870574787%2F Conclusion  Clinical trials in pregnant women are mainly conducted with an efficacy objective regarding maternal–fetal prevention and in obstetric diseases to study labor induction and abortive measures. This is in line with the type of intervention and drugs involved. Content Type Journal ArticleCategory Review ArticlePages 1-4DOI 10.1007/s00228-011-1145-xAuthors Viviana Domínguez, Department of Clinical Pharmacology, UASP, Hospital Clinic Barcelona, Villarroel 170, 08036 Barcelona, SpainNuria Ramos, Department of Clinical Pharmacology, UASP, Hospital Clinic Barcelona, Villarroel 170, 08036 Barcelona, SpainAbiguei Torrents, Statistics and Methodology Support Unit. IDIBAPS, Hospital Clinic Barcelona, Villarroel 170, 08036 Barcelona, SpainDavid García, Department ... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5408405 Thu, 10 Nov 2011 16:48:32 +0100 5408405 http://www.medworm.com/index.php?rid=5408406&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ffu70u8v754402w61%2F Conclusion  According to our results from a Turkish pediatric population, lansoprazole is a suitable probe drug for phenotyping CYP2C19. The CYP2C19*2 and *17 variants should be taken into consideration in predicting the clinical outcome of therapy with lansoprazole in the pediatric population. Content Type Journal ArticleCategory PharmacogeneticsPages 1-8DOI 10.1007/s00228-011-1151-zAuthors Ersin Gumus, Department of Pharmacology, Faculty of Medicine, Hacettepe University, Sihhiye, Ankara, TurkeyOzgur Karaca, Department of Pharmacology, Faculty of Medicine, Hacettepe University, Sihhiye, Ankara, TurkeyMelih O. Babaoglu, Department of Pharmacology, Faculty of Medicine, Hacettepe University, Sihhiye, Ankara, TurkeyGökhan Baysoy, Pediatric Gastroenterology, Hepatology... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5408406 Thu, 10 Nov 2011 16:48:31 +0100 5408406 http://www.medworm.com/index.php?rid=5408407&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2384761u13056604%2F Conclusions  The response to warfarin during induction is influenced by factor VII R353Q polymorphism. The prospective use of this polymorphism, along with CYP2C9 and VKORC1, may enhance the accuracy of warfarin loading. However, the impact of R353Q polymorphism on overall warfarin response is subtle, and it is therefore unlikely that its use would be of clinical importance. Content Type Journal ArticleCategory PharmacogeneticsPages 1-11DOI 10.1007/s00228-011-1143-zAuthors Liat Mlynarsky, Clinical Pharmacology Unit, Division of Medicine, Hadassah University Hospital, Jerusalem, 91120 IsraelIdit Bejarano-Achache, Clinical Pharmacology Unit, Division of Medicine, Hadassah University Hospital, Jerusalem, 91120 IsraelMordechai Muszkat, Clinical Pharmacology Unit, Division ... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5408407 Wed, 09 Nov 2011 17:51:29 +0100 5408407 http://www.medworm.com/index.php?rid=5408408&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fht90688297p8t5q1%2F Content Type Journal ArticleCategory ErratumPages 1-1DOI 10.1007/s00228-011-1155-8Authors Anton Pottegård, Research Unit of Clinical Pharmacology, University of Southern Denmark, JB Winsløwsvej 19,2, Odense, DenmarkJesper Hallas, Research Unit of Clinical Pharmacology, University of Southern Denmark, JB Winsløwsvej 19,2, Odense, Denmark Journal European Journal of Clinical PharmacologyOnline ISSN 1432-1041Print ISSN 0031-6970 (Source: European Journal of Clinical Pharmacology) European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5408408 Wed, 09 Nov 2011 17:51:28 +0100 5408408 http://www.medworm.com/index.php?rid=5408409&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1766562t47904448%2F Conclusions  In healthy volunteers treated for 14 days, once-daily fingolimod doses of 0.5 mg and 1.25 mg had no effect on cardiac or pulmonary function beyond a transient decrease in heart rate at treatment initiation. Content Type Journal ArticleCategory PharmacodynamicsPages 1-8DOI 10.1007/s00228-011-1146-9Authors Robert Schmouder, Novartis Institutes of Biomedical Research, Cambridge, MA, USASam Hariry, Novartis Pharma AG, Basel, SwitzerlandOlivier J. David, Novartis Pharma AG, Basel, Switzerland Journal European Journal of Clinical PharmacologyOnline ISSN 1432-1041Print ISSN 0031-6970 (Source: European Journal of Clinical Pharmacology) European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5408409 Wed, 09 Nov 2011 17:51:26 +0100 5408409 http://www.medworm.com/index.php?rid=5387188&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd321v1414414u454%2F Conclusions  The inclusion of both age and weight to predict accurate EFV CL values for the respective genotype groups within this paediatric population was required, whereas the addition of gender and body surface area did not improve the predictions. The importance of introducing IOV in a PK model for a longitudinal study with sparsely collected data was again highlighted by this investigation. Content Type Journal ArticleCategory Clinical TrialPages 1-9DOI 10.1007/s00228-011-1148-7Authors M. Viljoen, Unit for Drug Research and Development, Division of Pharmacology, School of Pharmacy, North-West University, Potchefstroom, South AfricaM. O. Karlsson, Division of Pharmacokinetics and Drug Therapy, Department of Pharmaceutical Biosciences, Faculty of Pharmacy, Uppsal... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5387188 Sat, 05 Nov 2011 17:11:22 +0100 5387188 http://www.medworm.com/index.php?rid=5387189&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj2052j43463t6800%2F Conclusions  On the basis of the effectiveness data presently available, fingolimod seems to offer the advantage of oral administration together with the most favorable profile in terms of relapse-free rate at the 1-year follow-up assessment. Content Type Journal ArticleCategory Short CommunicationPages 1-8DOI 10.1007/s00228-011-1141-1Authors Fabiola Del Santo, Laboratorio SIFO di Farmacoeconomia, c/o Area Vasta Centro Toscana, Regional Health System, Via Guimaraes 9-11, 59100 Prato, ItalyDario Maratea, Laboratorio SIFO di Farmacoeconomia, c/o Area Vasta Centro Toscana, Regional Health System, Via Guimaraes 9-11, 59100 Prato, ItalyValeria Fadda, Laboratorio SIFO di Farmacoeconomia, c/o Area Vasta Centro Toscana, Regional Health System, Via Guimaraes 9-11, 59100 Prato,... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5387189 Fri, 04 Nov 2011 16:48:38 +0100 5387189 http://www.medworm.com/index.php?rid=5387190&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F57l43j5125316g06%2F Conclusions  This descriptive case series provides more detailed information on the acute toxicity related to the use of D2PM. This information is useful for clinical pharmacologists and clinicians managing these individuals to be able to provide more appropriate advice on the acute toxicity associated with the use of D2PM, particularly in relation to the prolonged neuropsychiatric symptoms seen. Content Type Journal ArticleCategory PharmacodynamicsPages 1-5DOI 10.1007/s00228-011-1142-0Authors David M. Wood, Clinical Toxicology, Guy’s and St Thomas’ NHS Foundation Trust and Kings Health Partners, London, UKMalgorzata Puchnarewicz, Analytical Services International Ltd, St George’s University of London, London, UKAtholl Johnston, Barts and The London School of ... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5387190 Mon, 31 Oct 2011 17:02:27 +0100 5387190 http://www.medworm.com/index.php?rid=5387191&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw412107g46r38620%2F Conclusion  This study shows that individuals are at risk of significant caffeine toxicity related to the high caffeine content of some novel psychoactive substances. Clinicians, including clinical pharmacologists, need to be aware of this to ensure that the management of acute recreational drug toxicity is appropriate and that over-correction of any hypokalaemia does not occur. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionPages 1-5DOI 10.1007/s00228-011-1144-yAuthors Susannah Davies, Analytical Services International Ltd, St George’s, University of London, London, UKTerry Lee, Analytical Services International Ltd, St George’s, University of London, London, UKJohn Ramsey, TICTAC Communications Ltd, St. George’s, University of Londo... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5387191 Sat, 29 Oct 2011 05:47:42 +0100 5387191 http://www.medworm.com/index.php?rid=5360537&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe1557793247m65r7%2F Conclusions  While the systemic pharmacokinetics was comparable between subjects, the local distribution of ropivacaine was highly variable after TAP block. Content Type Journal ArticleCategory Pharmacokinetics and DispositionPages 1-7DOI 10.1007/s00228-011-1139-8Authors D. Latzke, Department of Clinical Pharmacology, Division of Clinical Pharmacokinetics and Imaging, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, AustriaP. Marhofer, Department of Anaesthesia, Intensive Care Medicine and Pain Therapy, Medical University of Vienna, Vienna, AustriaS. C. Kettner, Department of Anaesthesia, Intensive Care Medicine and Pain Therapy, Medical University of Vienna, Vienna, AustriaK. Koppatz, Department of Pharmacology, Medical University of Vienna, Vienn... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5360537 Fri, 28 Oct 2011 16:58:22 +0100 5360537 http://www.medworm.com/index.php?rid=5360538&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fwr4r7j1210t72t5q%2F Conclusions  Ribavirin hemodialysis clearance (CLhd = 74.5 ml/min) represented approximately 50% of the renal clearance (CLr) measured in subjects with normal renal function (CLr = 129 ml/min). Content Type Journal ArticleCategory Pharmacokinetics and DispositionPages 1-4DOI 10.1007/s00228-011-1137-xAuthors Samir K. Gupta, Departments of Drug Metabolism, Merck Research Laboratory, Kenilworth, NJ, USABhavna Kantesaria, Departments of Drug Metabolism, Merck Research Laboratory, Kenilworth, NJ, USAPaul Glue, Departments of Drug Metabolism, Merck Research Laboratory, Kenilworth, NJ, USA Journal European Journal of Clinical PharmacologyOnline ISSN 1432-1041Print ISSN 0031-6970 (Source: European Journal of Clinical Pharmacology) European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5360538 Fri, 28 Oct 2011 16:58:21 +0100 5360538 http://www.medworm.com/index.php?rid=5347719&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr725841727264211%2F Content Type Journal ArticleCategory EditorialPages 1-3DOI 10.1007/s00228-011-1135-zAuthors Roser Llop, Fundació Institut Català de Farmacologia, Pg. Vall d’Hebron, 119–129, 08035 Barcelona, SpainMontse Bosch, Departament de Farmacologia, Terapèutica i Toxicologia, Universitat Autònoma de Barcelona, Barcelona, SpainAlbert Figueras, Fundació Institut Català de Farmacologia, Pg. Vall d’Hebron, 119–129, 08035 Barcelona, SpainJoan-Ramon Laporte, Fundació Institut Català de Farmacologia, Pg. Vall d’Hebron, 119–129, 08035 Barcelona, Spain Journal European Journal of Clinical PharmacologyOnline ISSN 1432-1041Print ISSN 0031-6970 (Source: European Journal of Clinical Pharmacology) European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5347719 Thu, 20 Oct 2011 15:54:09 +0100 5347719 http://www.medworm.com/index.php?rid=5336068&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F663p35688580h541%2F Conclusion  The myelotoxicity in patients receiving FAC is related to the activity of the phase-II enzyme GSTA1 but is independent of the formation of 4-OH-CP. Content Type Journal ArticleCategory PharmacogeneticsPages 1-7DOI 10.1007/s00228-011-1134-0Authors Nasir Ali Afsar, College of Medicine, Alfaisal University, Riyadh, Saudi ArabiaMike Ufer, Institute of Experimental and Clinical Pharmacology, Christian Albrechts University (CAU) Kiel, Hospitalstr. 4, Kiel, GermanySierk Haenisch, Institute of Experimental and Clinical Pharmacology, Christian Albrechts University (CAU) Kiel, Hospitalstr. 4, Kiel, GermanyCornelia Remmler, Institute of Experimental and Clinical Pharmacology, Christian Albrechts University (CAU) Kiel, Hospitalstr. 4, Kiel, GermanyAhmed Mateen, Karach... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5336068 Wed, 19 Oct 2011 15:45:43 +0100 5336068 http://www.medworm.com/index.php?rid=5336069&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc12674v73716p228%2F Conclusions  A LSS model to predict AUCOPZ/AUC5OH, and thus CYP2C19 activity, was generated for Caucasian CYP2C19*1/*1 subjects. However, additional model validation is needed prior to general use. LSS models to predict AUCOPZ/AUCSUL, and thus CYP3A activity, were not possible, even upon stratification by CYP2C19 genotype and ethnicity. Content Type Journal ArticleCategory Pharmacokinetics and DispositionPages 1-7DOI 10.1007/s00228-011-1136-yAuthors Eileen B. Lawson, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego (UCSD), 9500 Gilman Drive, MC 0714, La Jolla, CA 92093-0714, USAJerry C. Wu, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego (UCSD), 9500 Gilman Drive, MC 0714, La Jolla, CA... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5336069 Tue, 18 Oct 2011 16:00:17 +0100 5336069 http://www.medworm.com/index.php?rid=5336071&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk3w8811j47721162%2F Content Type Journal ArticleCategory Letter to the EditorsPages 1-2DOI 10.1007/s00228-011-1140-2Authors Gordon I. A. MacDonald, Department of Rheumatology, Aberdeen Royal Infirmary, Aberdeen, UKGraeme P. Currie, Department of Respiratory Medicine, Aberdeen Royal Infirmary, Aberdeen, UKDavid M. Reid, Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD UK Journal European Journal of Clinical PharmacologyOnline ISSN 1432-1041Print ISSN 0031-6970 (Source: European Journal of Clinical Pharmacology) European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5336071 Tue, 18 Oct 2011 16:00:16 +0100 5336071 http://www.medworm.com/index.php?rid=5336070&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F46254348508n3186%2F Conclusion  Our results suggest that apart from the individual effect of ITPA 94 C→A, epistatic interactions between the variations of TPMT (*3C, *12) and ITPA (ex2, ex3) are associated with the 6-MP toxicity. Testing these variants facilitates tailoring of the 6-MP therapy in children with ALL. Content Type Journal ArticleCategory PharmacogeneticsPages 1-9DOI 10.1007/s00228-011-1133-1Authors Patchva Dorababu, Department of Medical Oncology, Nizam’s Institute of Medical Sciences, Panjagutta, Hyderabad, Andhra Pradesh, India PIN: 500082Narayana Nagesh, Centre for Cellular and Molecular Biology, Hyderabad, IndiaVijay Gandhi Linga, Department of Medical Oncology, Nizam’s Institute of Medical Sciences, Panjagutta, Hyderabad, Andhra Pradesh, India PIN: 500082Sadashi... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5336070 Tue, 18 Oct 2011 16:00:16 +0100 5336070 http://www.medworm.com/index.php?rid=5336072&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft53u2773721134vm%2F Conclusion  A high frequency of ADR occurrence was identified, with many of the ADRs being potentially preventable. Patients with renal dysfunction or cardiac arrhythmias and those receiving polypharmacy were at an increased risk for developing an ADR in the CCU. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionPages 1-7DOI 10.1007/s00228-011-1138-9Authors Padmini Devi, Department of Pharmacology, St. John’s Medical College, Koramangala, Bangalore, Karnataka 560034, IndiaDeepak Y. Kamath, Department of Pharmacology, St. John’s Medical College, Koramangala, Bangalore, Karnataka 560034, IndiaNaveen Anthony, Department of Pharmacology, St. John’s Medical College, Koramangala, Bangalore, Karnataka 560034, IndiaSushma Santosh, Department of ... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5336072 Tue, 18 Oct 2011 16:00:13 +0100 5336072 http://www.medworm.com/index.php?rid=5336073&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd23g1wq064043251%2F Conclusions  No significant effects of CYP2B6 and UGT1A9 SNPs or age on propofol metabolism were revealed in this pilot study, but there was a pronounced effect of sex, a finding that indicates an important factor for the previously described sex difference in systemic clearance of propofol seen. Content Type Journal ArticleCategory Pharmacokinetics and DispositionPages 1-10DOI 10.1007/s00228-011-1132-2Authors Irena Loryan, Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, SE-171 77 Stockholm, SwedenMarja Lindqvist, Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, SE-171 77 Stockholm, SwedenInger Johansson, Section of Pharmacogenetics, Department of Physiology and Pharmacology, ... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5336073 Tue, 18 Oct 2011 05:59:00 +0100 5336073 http://www.medworm.com/index.php?rid=5324162&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm05786324w5q51u2%2F Conclusion  Our results suggest no correlation between CAG repeat polymorphism in the AR gene and response to treatment with LEF in women with RA. Content Type Journal ArticleCategory PharmacogeneticsPages 1-7DOI 10.1007/s00228-011-1131-3Authors Violetta Dziedziejko, Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111 Szczecin, PolandMateusz Kurzawski, Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111 Szczecin, PolandKrzysztof Safranow, Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111 Szczecin, PolandAndrzej Ossowski, Department of Forensic Medicine, Pomeranian Medical University, Powstancow ... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5324162 Thu, 13 Oct 2011 15:50:34 +0100 5324162 http://www.medworm.com/index.php?rid=5314701&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk414888778522j76%2F Content Type Journal ArticleCategory Letter to the EditorsPages 1-2DOI 10.1007/s00228-011-1126-0Authors Usha Rao, West Suffolk Hospital, Bury St Edmunds, UKAjit Agarwal, West Suffolk Hospital, Bury St Edmunds, UK Journal European Journal of Clinical PharmacologyOnline ISSN 1432-1041Print ISSN 0031-6970 (Source: European Journal of Clinical Pharmacology) European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5314701 Tue, 11 Oct 2011 15:54:15 +0100 5314701 http://www.medworm.com/index.php?rid=5304595&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl8k6332712713277%2F Conclusions  This study shows that pharmacy-initiated PGt screening is feasible for a primary care setting. Content Type Journal ArticleCategory PharmacogeneticsPages 1-8DOI 10.1007/s00228-011-1130-4Authors J. J. Swen, Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, P.O. Box 9600, NL 2300 RC, Leiden, The NetherlandsT. van der Straaten, Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, P.O. Box 9600, NL 2300 RC, Leiden, The NetherlandsJ. A. M. Wessels, Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, P.O. Box 9600, NL 2300 RC, Leiden, The NetherlandsM. L. Bouvy, Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrech... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5304595 Fri, 07 Oct 2011 15:57:02 +0100 5304595 http://www.medworm.com/index.php?rid=5297164&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb702jl2511p131l3%2F Conclusion  There were no substantial differences in the safety, pharmacokinetics or pharmacodynamics of vorapaxar between Japanese and Caucasian subjects. Content Type Journal ArticleCategory Pharmacokinetics and DispositionPages 1-10DOI 10.1007/s00228-011-1127-zAuthors Teddy Kosoglou, Merck Sharp & Dohme Corp., Whitehouse Station, NJ, USALarisa Reyderman, Merck Sharp & Dohme Corp., Whitehouse Station, NJ, USAClaudia Kasserra, Merck Sharp & Dohme Corp., Whitehouse Station, NJ, USALisa K. Jennings, University of Tennessee Health Science Center, Memphis, TN, USASophia Young, Merck Sharp & Dohme Corp., Whitehouse Station, NJ, USAFengjuan Xuan, Merck Sharp & Dohme Corp., Whitehouse Station, NJ, USAJinglan Pei, Merck Sharp & Dohme Corp., Whitehouse Station, NJ, USAStephen... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5297164 Tue, 04 Oct 2011 05:51:13 +0100 5297164 http://www.medworm.com/index.php?rid=5297165&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr616m77mt057q570%2F Conclusions  Based on these results, trough concentration monitoring can be considered an appropriate procedure for routine tacrolimus dosage adjustment in adult LDLT patients. Monitoring of calcineurin activity at the trough time point was also found to be potentially useful for predicting the immunological status of the patient during the tacrolimus dosing interval. Content Type Journal ArticleCategory PharmacodynamicsPages 1-8DOI 10.1007/s00228-011-1129-xAuthors Ikuko Yano, Department of Pharmacy, Faculty of Medicine, Kyoto University Hospital, Kyoto University, Kyoto, JapanSatohiro Masuda, Department of Pharmacy, Faculty of Medicine, Kyoto University Hospital, Kyoto University, Kyoto, JapanHiroto Egawa, Department of Surgery, Graduate School of Medicine, Kyoto Un... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5297165 Tue, 04 Oct 2011 05:51:11 +0100 5297165 http://www.medworm.com/index.php?rid=5285889&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl624577qn4545171%2F Conclusions  The total number of 26 ARs recorded in 8 years is limited; however, the an under-reporting effect cannot be excluded. Moreover, taking into account the seriousness of the reported ARs, the low number of reports does not represent a guarantee of safety. To reduce the risk of an adverse outcome, herbal laxatives should be used only over the short term. Content Type Journal ArticleCategory Review ArticlePages 1-8DOI 10.1007/s00228-011-1128-yAuthors Annabella Vitalone, Department of Physiology and Pharmacology V. Erspamer, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, ItalyFrancesca Menniti-Ippolito, National Centre for Epidemiology, National Institute of Health, Viale Regina Elena 299, 00161 Rome, ItalyRoberto Raschetti, National Centre for... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5285889 Sun, 02 Oct 2011 05:47:31 +0100 5285889 http://www.medworm.com/index.php?rid=5260979&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn33hj1845075g245%2F Conclusion  Vorapaxar provided rapid and sustained dose-related inhibition of platelet aggregation without affecting bleeding or clotting times. Content Type Journal ArticleCategory PharmacodynamicsPages 1-10DOI 10.1007/s00228-011-1120-6Authors Teddy Kosoglou, Merck, Whitehouse Station, NJ, USALarisa Reyderman, Merck, Whitehouse Station, NJ, USARenger G. Tiessen, PRA International, Zuidlaren, the NetherlandsAndré A. van Vliet, PRA International, Zuidlaren, the NetherlandsRobert R. Fales, Merck, Whitehouse Station, NJ, USARobert Keller, Merck, Whitehouse Station, NJ, USABo Yang, Merck, Whitehouse Station, NJ, USADavid L. Cutler, Merck, Whitehouse Station, NJ, USA Journal European Journal of Clinical PharmacologyOnline ISSN 1432-1041Print ISSN 0031-6970 (Source:... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5260979 Wed, 21 Sep 2011 05:48:20 +0100 5260979 http://www.medworm.com/index.php?rid=5260980&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe6w3122t0607579k%2F This study highlights the importance of choosing a statistical method that reflects the complexity of data for interpretation of results from observational studies. The multivariate model appears to be well suited to describe the complex relationship between vitamin K intake and VKA dose. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionPages 1-8DOI 10.1007/s00228-011-1123-3Authors Morten Arendt Rasmussen, Department of Food Science/Quality and Technology, Faculty of Life Sciences, University of Copenhagen, Copenhagen, DenmarkJane Skov, Unit for Thrombosis Research, Institute of Public Health, University of Southern Denmark, Esbjerg, DenmarkElse-Marie Bladbjerg, Unit for Thrombosis Research, Institute of Public Health, University of Southern Denmark, E... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5260980 Wed, 21 Sep 2011 05:48:18 +0100 5260980 http://www.medworm.com/index.php?rid=5237994&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq41620082714n424%2F Conclusions  This study indicates that physicians’ prescribing strategy towards initial users is crucial in order to prevent inappropriate drug use. There is a need to implement relevant guidelines and systems for structured clinical audits in general practice. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionPages 1-9DOI 10.1007/s00228-011-1124-2Authors Svein R. Kjosavik, Research Group for General Practice, Department of Public Health and Primary Health Care, University of Bergen, P.O. Box 7804, 5020 Bergen, NorwaySabine Ruths, Research Group for General Practice, Department of Public Health and Primary Health Care, University of Bergen, P.O. Box 7804, 5020 Bergen, NorwaySteinar Hunskaar, Research Group for General Practice, Department of ... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5237994 Sat, 17 Sep 2011 17:06:26 +0100 5237994 http://www.medworm.com/index.php?rid=5237993&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1578304x52786513%2F Conclusions  Our findings reaffirm that the SLCO1B1 genetic risk appears to be greater in those patients receiving simvastatin compared with those receiving atorvastatin. This suggests that the importance of SLCO1B1 haplotypes depends on the specific statin that has been used. Content Type Journal ArticleCategory PharmacogeneticsPages 1-7DOI 10.1007/s00228-011-1125-1Authors Paulo Caleb Junior Lima Santos, Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of Sao Paulo Medical School, Avenue Dr. Enéas de Carvalho Aguiar, 44 Cerqueira César, São Paulo, SP, Brazil CEP 05403-000Ana Carolina Moron Gagliardi, Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of Sao Paulo Medical School, Avenue Dr. Enéa... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5237993 Sat, 17 Sep 2011 17:06:26 +0100 5237993 http://www.medworm.com/index.php?rid=5225971&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft526h7322v789t35%2F Conclusion  A fatal buprenorphine poisoning is typically accidental, and the average victim is a 27-year-old male addict. Circumstantial and environmental factors seem to be crucial in determining the outcome of the poisoning. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionPages 1-9DOI 10.1007/s00228-011-1122-4Authors Margareeta Häkkinen, Department of Forensic Medicine, University of Helsinki, Hjelt Institute, PO Box 40, Kytösuontie 11, Helsinki, 00014 FinlandTerhi Launiainen, Department of Forensic Medicine, University of Helsinki, Hjelt Institute, PO Box 40, Kytösuontie 11, Helsinki, 00014 FinlandErkki Vuori, Department of Forensic Medicine, University of Helsinki, Hjelt Institute, PO Box 40, Kytösuontie 11, Helsinki, 00014 FinlandIlk... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5225971 Fri, 16 Sep 2011 16:49:36 +0100 5225971 http://www.medworm.com/index.php?rid=5225972&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh266567967746878%2F Conclusions  Reducing the dose of LCE by 25 mg following the first morning dose results in a more consistent levodopa Cmax profile, avoiding levodopa accumulation while maintaining significantly higher Cmin levels and AUC0−14 values compared with LC. Content Type Journal ArticleCategory Pharmacokinetics and DispositionPages 1-9DOI 10.1007/s00228-011-1121-5Authors Kimmo Ingman, Phase I Unit, Orion Pharma, Orion Corporation, Espoo, FinlandTarja Naukkarinen, Orion Pharma, Orion Corporation, Turku, FinlandMikko Vahteristo, Orion Pharma, Orion Corporation, Kuopio, FinlandIrja Korpela, Orion Pharma, Orion Corporation, Turku, FinlandMikko Kuoppamäki, Orion Pharma, Orion Corporation, Turku, FinlandJuha Ellmén, Orion Pharma, Orion Corporation, Turku, Finland Jou... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5225972 Fri, 16 Sep 2011 16:49:35 +0100 5225972 http://www.medworm.com/index.php?rid=5209094&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8073h60224762426%2F Abstract  Congestive heart failure (CHF) is the most frequent cause of hospitalization for patients >65 years of age and continues to be a major public health burden among the ageing population. Unlike therapy for chronic CHF, there has been only modest progress in medical treatment for acutely decompensated CHF over the past several decades. Moreover, current treatment—consisting generally of diuretic, inotropic, and vasodilatory agents–is associated with many limitations in clinical practice. Natriuretic peptides provide a promising mechanism of action in the pathophysiologic background for CHF treatment based on their vasodilatory and diuretic properties and effective inhibition of the renin–angiotensin–aldosterone system, which is activated early in the ... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5209094 Thu, 08 Sep 2011 06:09:43 +0100 5209094 http://www.medworm.com/index.php?rid=5209097&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fpw16jg41t77u3612%2F Content Type Journal ArticleCategory ErratumPages 1-1DOI 10.1007/s00228-011-1116-2Authors Cláudia de Oliveira Baraldi, Department of Gynecology and Obstetrics, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, BrazilVera Lucia Lanchote, Department of Clinical, Toxicologic and Bromatologic Analyses, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, BrazilNatalícia de Jesus Antunes, Department of Clinical, Toxicologic and Bromatologic Analyses, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, BrazilTeresa Maria de Jesus Ponte Carvalho, Department of Clinical, Toxicologic and Bromatologic Analyses, Faculty of Pharmaceutical Sciences of Ribeirão Preto, Univer... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5209097 Thu, 08 Sep 2011 06:09:42 +0100 5209097 http://www.medworm.com/index.php?rid=5209096&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F045283m471215250%2F Conclusion  Although based on only a limited number of subjects, our results suggest that the CYP2B6*6 and CYP2B6*18 alleles should affect hepatic metabolic activity and elevate the systemic circulation level of efavirenz, which may lead to toxicity in Zimbabwean HIV patients. Content Type Journal ArticleCategory PharmacogeneticsPages 1-5DOI 10.1007/s00228-011-1118-0Authors Milimo Maimbo, Laboratory for International Alliance, RIKEN Center for Genomic Medicine, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, 230-0045 JapanKazuma Kiyotani, Laboratory for Pharmacogenetics, RIKEN Center for Genomic Medicine, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, 230-0045 JapanTaisei Mushiroda, Laboratory for Pharmacogenetics, RIKEN Center for Genomic Medicine, 1-7-22 Suehiro-cho, Tsurumi-k... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5209096 Thu, 08 Sep 2011 06:09:42 +0100 5209096 http://www.medworm.com/index.php?rid=5209098&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft41m2n0m43187301%2F Content Type Journal ArticleCategory Letter to the EditorsPages 1-3DOI 10.1007/s00228-011-1119-zAuthors Hiroshi Asajima, Division of Cardiology, Hakodate Central General Hospital, 33-2 Hon-cho, Hakodate, Hokkaido, JapanNaotaka Saito, Division of Cardiology, Hakodate Central General Hospital, 33-2 Hon-cho, Hakodate, Hokkaido, JapanYoshinori Ohmura, Division of Cardiology, Hakodate Central General Hospital, 33-2 Hon-cho, Hakodate, Hokkaido, JapanKazue Ohmura, Division of Cardiology, Hakodate Central General Hospital, 33-2 Hon-cho, Hakodate, Hokkaido, Japan Journal European Journal of Clinical PharmacologyOnline ISSN 1432-1041Print ISSN 0031-6970 (Source: European Journal of Clinical Pharmacology) European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5209098 Tue, 06 Sep 2011 15:50:39 +0100 5209098 http://www.medworm.com/index.php?rid=5184215&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8u3566k0123nx452%2F Conclusions  Induction to a pharmacodynamic steady state for warfarin for future multiple-dose warfarin drug-interaction studies in healthy volunteers may be predicted using a pharmacogenetic-based dosing algorithm. Simulations revealed that the desired subtherapeutic INR level may be achieved by reducing the predicted dose by approximately 15%. Further study is needed to assess the applicability of this approach to decrease attrition rates and the time needed to reach INR stabilization. Content Type Journal ArticleCategory PharmacodynamicsPages 1-9DOI 10.1007/s00228-011-1114-4Authors Jill C. Chappell, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USAGemma Dickinson, Eli Lilly and Company, Windlesham, Surrey, UKMalcolm I. Mitchell, Eli Lilly... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5184215 Wed, 31 Aug 2011 15:53:21 +0100 5184215 http://www.medworm.com/index.php?rid=5184214&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq300160552657575%2F Conclusions  Eprosartan monotherapy is equivalent to many first-line antihypertensive agents and is effective for the treatment of essential hypertension, especially for isolated systolic hypertension. The favorable efficacy and tolerability make eprosartan worthwhile to be taken into consideration by physicians. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionPages 1-11DOI 10.1007/s00228-011-1107-3Authors Feng-Ying Xu, Company of Anesthesiology, Second Military Medical University, 800 Xiangyin Road, Shanghai, 200433 People’s Republic of ChinaBo Yang, Company 10, Second Military Medical University, 800 Xiangyin Road, Shanghai, 200433 People’s Republic of ChinaDuo Shi, Department of Biochemical Pharmacy, School of Pharmacy, Second Militar... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5184214 Wed, 31 Aug 2011 15:53:21 +0100 5184214 http://www.medworm.com/index.php?rid=5170496&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F861m84450662182n%2F Conclusions  Repeated administration of berberine (300 mg, t.i.d., p.o.) decreased CYP2D6, 2C9, and CYP3A4 activities. Drug-drug interactions should be considered when berberine is administered. Content Type Journal ArticleCategory Short CommunicationPages 1-5DOI 10.1007/s00228-011-1108-2Authors Ying Guo, Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University, XiangYa School of Medicine, 110 Xiang-Ya Road, Changsha, Hunan 410078, People’s Republic of ChinaYao Chen, Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University, XiangYa School of Medicine, 110 Xiang-Ya Road, Changsha, Hunan 410078, People’s Republic of ChinaZhi-rong Tan, Pharmacogenetics Research Institute, Institute... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5170496 Thu, 25 Aug 2011 15:50:38 +0100 5170496 http://www.medworm.com/index.php?rid=5162002&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh3882j5883718j02%2F Conclusions  Children participating in drug RCTs experience a significant amount and a wide range of ADRs. DSMBs are needed to ensure the safety of paediatric participants in clinical drug trials. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionPages 1-6DOI 10.1007/s00228-011-1112-6Authors Khairun Nain Bin Nor Aripin, Academic Division of Child Health, University of Nottingham, Derbyshire Children’s Hospital, Derby, UKImti Choonara, Academic Division of Child Health, University of Nottingham, Derbyshire Children’s Hospital, Derby, UKHelen M. Sammons, Academic Division of Child Health, University of Nottingham, Derbyshire Children’s Hospital, Derby, UK Journal European Journal of Clinical PharmacologyOnline ISSN 1432-1041Print ISS... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5162002 Fri, 19 Aug 2011 16:01:07 +0100 5162002 http://www.medworm.com/index.php?rid=5162003&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy6m7630873210571%2F Conclusions  It appears that grapefruit juice increases the bioavailability of tolvaptan, but does not affect its systemic elimination. The adverse event profile was consistent with the aquaretic effect of tolvaptan as urinary frequency, thirst, and dry mouth were the most frequently reported events. Content Type Journal ArticleCategory Short CommunicationPages 1-5DOI 10.1007/s00228-011-1106-4Authors Susan E. Shoaf, Clinical Pharmacology, Otsuka Pharmaceutical Development & Commercialization, Inc., 2440 Research Boulevard, Rockville, MD 20850, USASuresh Mallikaarjun, Clinical Pharmacology, Otsuka Pharmaceutical Development & Commercialization, Inc., 2440 Research Boulevard, Rockville, MD 20850, USAPatricia Bricmont, Global Clinical Development, Otsuka Pharmaceutical ... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5162003 Fri, 19 Aug 2011 06:39:37 +0100 5162003 http://www.medworm.com/index.php?rid=5162004&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp32m6358v8467178%2F Conclusions  This is the first study to explore the views of healthy children on unlicensed medicine use in children. Children were able to recognise potential risks associated with the unlicensed use of medicines and felt it is necessary to test and license more medicines in children. Practice implications  Health care professionals should consider the views of children in decisions that affect their health. Content Type Journal ArticleCategory Clinical TrialPages 1-8DOI 10.1007/s00228-011-1110-8Authors Tareq Mukattash, Clinical and Practice Research Group, School of Pharmacy, Medical Biology Centre, Queen’s University Belfast, 97 Lisburn Road, BT9 7BL Belfast, UKKaren Trew, School of Psychology, Queen’s University, BT7 1NN Belfast, UKAhmed F. H... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5162004 Wed, 17 Aug 2011 05:57:42 +0100 5162004 http://www.medworm.com/index.php?rid=5132298&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh82w572l1u213334%2F Content Type Journal ArticlePages 1-2DOI 10.1007/s00228-011-1113-5Authors Guillaume Moulis, Service de Pharmacologie Clinique, Faculté de Médecine, Centre Midi-Pyrénées de Pharmacovigilance, de Pharmacoépidémiologie et d’Informations sur le Médicament, Unité INSERM U 1027, Centre Hospitalier Universitaire de Toulouse, Université de Toulouse, 37 Allées Jules-Guesde, 31000 Toulouse, FranceArnaud Batz, Service de Pharmacologie Clinique, Faculté de Médecine, Centre Midi-Pyrénées de Pharmacovigilance, de Pharmacoépidémiologie et d’Informations sur le Médicament, Unité INSERM U 1027, Centre Hospitalier Universitaire de Toulouse, Université de Toulouse, 37 Allées Jules-Guesde, 31000 Toulouse, FranceGeneviève Durrieu, Service de Pharmacologie Clinique, Faculté de Méd... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5132298 Sat, 13 Aug 2011 06:07:42 +0100 5132298 http://www.medworm.com/index.php?rid=5132300&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8124464738105685%2F Conclusions   CYP2C9 genetic polymorphisms markedly affected the pharmacokinetics of irbesartan in this study sample. The CYP2C9*3 and CYP2C9*13 alleles appear to be associated with the decreased metabolism of irbesartan. Content Type Journal ArticlePages 1-6DOI 10.1007/s00228-011-1098-0Authors Chang-Ik Choi, Laboratory of Pharmacology, School of Pharmacy, Sungkyunkwan University, Suwon, 440-746 Republic of KoreaMi-Jeong Kim, Laboratory of Pharmacology, School of Pharmacy, Sungkyunkwan University, Suwon, 440-746 Republic of KoreaEun-Kyung Chung, Laboratory of Pharmacology, School of Pharmacy, Sungkyunkwan University, Suwon, 440-746 Republic of KoreaHye-In Lee, Laboratory of Pharmacology, School of Pharmacy, Sungkyunkwan University, Suwon, 440-746 Republic of KoreaChoo... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5132300 Sat, 13 Aug 2011 06:07:41 +0100 5132300 http://www.medworm.com/index.php?rid=5132299&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F163l678877526h50%2F Conclusions  Pharmacotherapy is complex in cirrhotic patients. Hepatologists should know the principles of dose adjustment in cirrhosis and renal failure, but also the most important pDDIs of the drugs used to treat liver disease and comorbidities in this population. Content Type Journal ArticlePages 1-10DOI 10.1007/s00228-011-1105-5Authors Carmen C. Franz, Division of Clinical Pharmacology and Toxicology, University Hospital, 4031 Basel, SwitzerlandSabin Egger, Division of Clinical Pharmacology and Toxicology, University Hospital, 4031 Basel, SwitzerlandChrista Born, Division of Clinical Pharmacology and Toxicology, University Hospital, 4031 Basel, SwitzerlandAlexandra E. Rätz Bravo, Division of Clinical Pharmacology and Toxicology, University Hospital, 4031 Basel, ... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5132299 Sat, 13 Aug 2011 06:07:41 +0100 5132299 http://www.medworm.com/index.php?rid=5132301&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fpxm8836384855024%2F Content Type Journal ArticlePages 1-1DOI 10.1007/s00228-011-1115-3Authors Silvio Garattini, Mario Negri Institute for Pharmacological Research, Via Giuseppe La Masa 19, Milan, Italy Journal European Journal of Clinical PharmacologyOnline ISSN 1432-1041Print ISSN 0031-6970 (Source: European Journal of Clinical Pharmacology) European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5132301 Sat, 13 Aug 2011 06:07:40 +0100 5132301 http://www.medworm.com/index.php?rid=5132302&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh4wmm44317l31834%2F Conclusion  This study shows that cultural influences may affect medicine use among first-generation immigrants from Pakistan after having lived 10 years or more in Norway. Although access to drugs and basic health care services seems to be problem free, language proficiency is a considerable problem that obstructs access to information and is detrimental to the level of communication with health professionals. Content Type Journal ArticlePages 1-8DOI 10.1007/s00228-011-1111-7Authors Helle Håkonsen, Department of Social Pharmacy, School of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, N – 0316 Oslo, NorwayElse-Lydia Toverud, Department of Social Pharmacy, School of Pharmacy, University of Oslo, Oslo, Norway Journal European Journal of Clinical Phar... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5132302 Fri, 12 Aug 2011 06:15:01 +0100 5132302 http://www.medworm.com/index.php?rid=5132303&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg174641p31146554%2F Conclusions  Intranasal lorazepam has more favourable pharmacokinetics than buccal lorazepam when considering the need for the rapid blood concentrations required for seizure termination. Further clinical evaluation of this route is required. Content Type Journal ArticlePages 1-5DOI 10.1007/s00228-011-1109-1Authors Mark Anderson, Great North Children’s Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP UKParag Tambe, Academic Division of Child Health, University of Nottingham, Derbyshire Children’s Hospital, Derby, UKHelen Sammons, Academic Division of Child Health, University of Nottingham, Derbyshire Children’s Hospital, Derby, UKHussain Mulla, Centre for Therapeutic Evaluation of Drugs in Children, ... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5132303 Fri, 12 Aug 2011 06:14:59 +0100 5132303 http://www.medworm.com/index.php?rid=5132304&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff682237u74w874g1%2F Conclusions  Fasudil greatly reduces the occurrence of CVS and cerebral infarction in SAH patients, significantly improves the clinical outcomes of the patients (as assessed by the Glasgow Outcome Scale). Because of the limited number of trials and samples available for analysis, the conclusions from the present study still need to be validated with results from large randomized, controlled clinical trials. Content Type Journal ArticlePages 1-9DOI 10.1007/s00228-011-1100-xAuthors Guang Jian Liu, Department of Neurology, Taihe Hospital Affiliated to Hubei University of Medicine, 32 Renmin Road, Shiyan City, Hubei Province 442000, ChinaZheng Jun Wang, Department of Pharmacy, Taihe Hospital Affiliated to Hubei University of Medicine, 32 Renmin Road, Shiyan City, Hubei ... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5132304 Fri, 12 Aug 2011 06:14:56 +0100 5132304 http://www.medworm.com/index.php?rid=5109645&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm646326071172520%2F Content Type Journal ArticlePages 1-1DOI 10.1007/s00228-011-1104-6Authors Vesna Mijatović, Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, SerbiaJelena Ćalasan, Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, SerbiaOlga Horvat, Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, SerbiaAna Sabo, Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, SerbiaZdenko Tomić, Department of Pharmacology, Faculty of Me... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5109645 Thu, 04 Aug 2011 15:30:43 +0100 5109645 http://www.medworm.com/index.php?rid=5098019&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn31p151382000gr6%2F Abstract  Pharmacoepidemiology is the study of the utilization and effects of drugs in clinical and population settings, and the outcomes of drug therapy. The growing trend of recording computerized data that will increasingly be automated into health care delivery is making the use of large datasets more and more common in pharmacoepidemiologic research. Most retrospective databases offer large populations and longer observation periods with real-world practice and can answer a variety of research questions quickly and cost-effectively. Observational studies, specifically using large databases, can complement findings from randomized clinical trials (RCTs) by assessing treatment effectiveness in patients encountered in daily clinical practice, although they are more expose... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5098019 Tue, 02 Aug 2011 06:14:30 +0100 5098019 http://www.medworm.com/index.php?rid=5088674&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn7x08l46017n6655%2F Conclusions  Based on the results, we conclude that most PSRs do not meet their ideal high standards of being equal partners to the specialist physicians they visit. More education is needed to achieve this goal. Content Type Journal ArticlePages 1-10DOI 10.1007/s00228-011-1103-7Authors Christoph L. Lassen, Department of Anaesthesiology, Pain Center, University Hospital Regensburg, Franz-Josef-Strauss-Allee 11, 93051 Regensburg, GermanyKirstin Fragemann, Center for Education, University Hospital Regensburg, Regensburg, GermanyTobias Klier, Department of Anaesthesiology, Pain Center, University Hospital Regensburg, Franz-Josef-Strauss-Allee 11, 93051 Regensburg, GermanyNicole Meyer, Department of Anaesthesiology, Pain Center, University Hospital Regensburg, Franz-Josef... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5088674 Fri, 29 Jul 2011 16:06:55 +0100 5088674 http://www.medworm.com/index.php?rid=5079679&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu711150122m4pw5h%2F Conclusions  The antimicrobial efficacy of the actual phase III study was consistent with the expectation from the Monte Carlo PD simulation. We were able to show that the optimal garenoxacin dosage regimens were successfully determined using prospective population PK/PD analysis and clinical trial simulations. Content Type Journal ArticlePages 1-15DOI 10.1007/s00228-011-1095-3Authors Yusuke Tanigawara, Department of Clinical Pharmacokinetics and Pharmacodynamics, School of Medicine, Keio University, Tokyo, 160-8582 JapanKenji Nozawa, Biostatics Group, Clinical Planning Department, Toyama Chemical Co., Ltd, Tokyo, JapanHisatsugu Tsuda, Research Laboratories, Toyama Chemical Co., Ltd, Toyama, Japan Journal European Journal of Clinical PharmacologyOnline ISSN 14... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5079679 Wed, 27 Jul 2011 15:47:10 +0100 5079679 http://www.medworm.com/index.php?rid=5079678&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F457217kh115422u6%2F Conclusions  In prescribing an oral anticancer agent, clinicians must consider the possibility that the consumption of specific food items has the potential to interfere with the pharmacokinetics and pharmacodynamics of the prescribed drug. Content Type Journal ArticlePages 1-8DOI 10.1007/s00228-011-1102-8Authors Antonio Ruggiero, Division of Paediatric Oncology, Catholic University of Rome–A. Gemelli Hospital, Largo A. Gemelli 8, 00168 Rome, ItalyMaria G. Cefalo, Division of Paediatric Oncology, Catholic University of Rome–A. Gemelli Hospital, Largo A. Gemelli 8, 00168 Rome, ItalyPaola Coccia, Division of Paediatric Oncology, Catholic University of Rome–A. Gemelli Hospital, Largo A. Gemelli 8, 00168 Rome, ItalyStefano Mastrangelo, Division of Paediatric Oncolog... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5079678 Wed, 27 Jul 2011 15:47:10 +0100 5079678 http://www.medworm.com/index.php?rid=5079680&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7u507452405h6142%2F Conclusion  The results suggest that strong opioid analgesics consumption rates in St. Petersburg yield those in Israel, and that the between-countries differences in opioid formularies availability and legal and regulatory barriers to opioids accessibility are responsible for the consumption discrepancies. Content Type Journal ArticlePages 1-7DOI 10.1007/s00228-011-1099-zAuthors Alexander M. Ponizovsky, Mental Health Services, Ministry of Health, 2 Ben Tabai Street, Jerusalem, 93591 IsraelMichael V. Pchelintsev, Department of Psychopharmacology, A.V. Valdman Institute of Pharmacology, St. Petersburg State I. P. Pavlov Medical University, St. Petersburg, RussiaEli Marom, Pharmaceutical Administration, Ministry of Health, Jerusalem, IsraelEdwin E. Zvartau, Department ... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5079680 Tue, 26 Jul 2011 15:49:19 +0100 5079680 http://www.medworm.com/index.php?rid=5079681&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fnp512q233205486t%2F Conclusions  Fluindione is not known to be a frequent cause of DRESS. However, the number of reports found is probably underestimated. The seriousness of DRESS, as all immuno-allergic adverse effects, contraindicates fluindione reintroduction. Coumarinic derivatives are the alternatives in patients who need oral anticoagulant treatment. Content Type Journal ArticlePages 1-5DOI 10.1007/s00228-011-1101-9Authors Amélie Daveluy, Université de Bordeaux, U657, 33000 Bordeaux, FranceBrigitte Milpied, CHU de Bordeaux, Service de Dermatologie, 33000 Bordeaux, FranceAnnick Barbaud, CHU de Nancy, Service de Dermatologie, Hôpital Fournier, 54000 Nancy, FranceBénédicte Lebrun-Vignes, AP-HP, Centre Régional de Pharmacovigilance, Hôpital Pitié-Salpêtrière, 75013 Paris, Fr... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5079681 Tue, 26 Jul 2011 15:49:18 +0100 5079681 http://www.medworm.com/index.php?rid=5063956&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc5343877r2283m17%2F Abstract  The use of unlicensed and off-label medicines in children is common because trials in children have not usually been performed during the drug development process. Consequently, the information available to paediatricians may not always be as detailed or as robust as that available when prescribing a medicine that is licensed for an approved indication. This has led to concerns that children may be receiving drugs at dosages that either lack efficacy or present safety problems. The latter in particular has received a great deal of attention. In this narrative review, we have evaluated the use of off-label and unlicensed medicines in children and whether and how frequently this predisposes to adverse drug reactions. Content Type Journal ArticlePages 1-8DOI 10.1... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5063956 Thu, 21 Jul 2011 18:16:59 +0100 5063956 http://www.medworm.com/index.php?rid=5063957&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk80p72h56752un45%2F Conclusions  This study does not support an association between dopamine agonist use and an increased risk of ischemic events requiring hospitalization. Content Type Journal ArticlePages 1-6DOI 10.1007/s00228-011-1084-6Authors Maurits E. L. Arbouw, Department of Clinical Pharmacy, Division Laboratory and Pharmacy, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The NetherlandsKris L. L. Movig, Department of Clinical Pharmacy, Medisch Spectrum Twente, Enschede, The NetherlandsHenk-Jan Guchelaar, Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The NetherlandsCees Neef, Department of Clinical Pharmacy and Toxicology, University Hospital Maastricht, Maastricht, The NetherlandsToine C. G. Egberts, Department of Cl... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5063957 Thu, 21 Jul 2011 18:16:57 +0100 5063957 http://www.medworm.com/index.php?rid=5063958&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw4733183587g4333%2F Abstract   The present work has the main objective of summarizing the history of pharmacovigilance and the associated methods and legislation and of showing how it could/should be reformulated in terms of a transition from a drug-centered to a patient/population-centered approach. The recurrent emergencies associated with new drug molecules raise many questions about the efficacy and efficiency of methodological tools as well as the role of regulatory systems. Drugs cannot be considered as an independent variable: the evaluation of all their effects must take into account the real contexts in which they are used and which affect not only their efficacy but also their tolerability and safety. Specific emphasis is given to recent and promising developments focused on the... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5063958 Tue, 19 Jul 2011 23:38:17 +0100 5063958 http://www.medworm.com/index.php?rid=5030623&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx27225717p8787q2%2F Content Type Journal ArticlePages 1-2DOI 10.1007/s00228-011-1074-8Authors Andrew Herxheimer, UK Cochrane Centre, Oxford, UK Journal European Journal of Clinical PharmacologyOnline ISSN 1432-1041Print ISSN 0031-6970 (Source: European Journal of Clinical Pharmacology) European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5030623 Wed, 13 Jul 2011 05:59:29 +0100 5030623 http://www.medworm.com/index.php?rid=5020962&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm0qh1140w7571283%2F Conclusions  There were marked differences in the degree of influence of paroxetine coadministration on the pharmacokinetics of aripiprazole between CYP2D6 EMs and IMs, but no apparent differences were found between two CYP2D6 genotypes in fluvoxamine coadministration. Aripiprazole can be used safely in combination with SSRIs that have a CYP enzyme-inhibitory action. Content Type Journal ArticlePages 1-9DOI 10.1007/s00228-011-1094-4Authors Junichi Azuma, Clinical Pharmacology and Pharmacogenomics, Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, 1-3-6, Minatojima, Chuo-ku, Kobe, 650–8530 JapanTomoko Hasunuma, Research Center for Clinical Pharmacology, Kitasato University, 5-9-1, Shirokane, Minato-ku, Tokyo, 108–0072 JapanMasanori K... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5020962 Fri, 08 Jul 2011 06:36:26 +0100 5020962 http://www.medworm.com/index.php?rid=5020963&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx70181263367p6n6%2F Conclusion   CYP2D6 genotypes caused expected differences in pharmacokinetics, but they had no pharmacodynamic consequence. CYP2D6 genotypes did not influence pain control, the adverse symptoms nausea and sedation or the risk for cognitive failure in this study of patients treated with oxycodone for cancer pain. Content Type Journal ArticlePages 1-10DOI 10.1007/s00228-011-1093-5Authors Trine Naalsund Andreassen, Pain and Palliation Research Group, Faculty of Medicine, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, 7489 Trondheim, NorwayIngrid Eftedal, Norwegian University of Science and Technology, 7489 Trondheim, NorwayPål Klepstad, Pain and Palliation Research Group, Faculty of Medicine, Department of Circulation and... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5020963 Thu, 07 Jul 2011 05:43:38 +0100 5020963 http://www.medworm.com/index.php?rid=5010036&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7418665858323788%2F Conclusions  Although much still needs to be done, it’s clear that with concerted efforts and appropriate resources, change is possible but slow. Retaining and fostering public and political interest in paediatric medicines is challenging, but pivotal for success. Content Type Journal ArticlePages 1-10DOI 10.1007/s00228-011-1089-1Authors Kalle Hoppu, Hospital for Children and Adolescents and Dept. of Clinical Pharmacology, University of Helsinki and Poison Information Centre, Helsinki University Central Hospital, P.O. Box 790, 00029 Helsinki, FinlandGabriel Anabwani, Botswana-Baylor Children’s Clinical Centre of Excellence, Gaborone, BotswanaFacundo Garcia-Bournissen, Buenos Aires Children’s Hospital “R Gutierrez”, Buenos Aires, ArgentinaMadlen Gazarian, Pae... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5010036 Wed, 06 Jul 2011 05:57:07 +0100 5010036 http://www.medworm.com/index.php?rid=4993756&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl4uux73314054207%2F Conclusions  An overwhelming majority of asthmatic children were not using long-term medications for asthma, in particular inhaled corticosteroids, regardless of the severity of their disease. This result points to the deficiencies of the Brazilian public health system in recognizing this important pharmacological need for child care and thereby limiting the access of these children to a group of efficacious, available, and low risk therapeutic medications. Content Type Journal ArticlePages 1-10DOI 10.1007/s00228-011-1092-6Authors Djanilson Barbosa Santos, Centro de Ciências da Saúde, Federal University of Recôncavo da Bahia, Santo Antônio de Jesus, Bahia, BrazilAlvaro A. Cruz, ProAR, Faculdade de Medicina da Bahia, Federal University of Bahia, Salvador, BrazilS... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=4993756 Wed, 29 Jun 2011 10:52:49 +0100 4993756 http://www.medworm.com/index.php?rid=4993757&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn1n15482q9p70222%2F Content Type Journal ArticlePages 1-3DOI 10.1007/s00228-011-1091-7Authors Amir M. Nia, Department of Internal Medicine III, University of Cologne, Kerpener Str. 62, 50937 Cologne, GermanyKristina M. Dahlem, Department of Internal Medicine III, University of Cologne, Kerpener Str. 62, 50937 Cologne, GermanyNatig Gassanov, Department of Internal Medicine III, University of Cologne, Kerpener Str. 62, 50937 Cologne, GermanyHansjörg Hungerbühler, Department of Neurology, Cantonal Hospital Aarau, Aarau, SwitzerlandUwe Fuhr, Department of Pharmacology, University of Cologne, Cologne, GermanyFikret Er, Department of Internal Medicine III, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany Journal European Journal of Clinical PharmacologyOnline ISSN 1432-1041Print ISSN 003... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=4993757 Tue, 28 Jun 2011 15:51:45 +0100 4993757 http://www.medworm.com/index.php?rid=4993758&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6r28770150hj7128%2F Conclusions  This analysis indicates persistence with antidepressants in the Australian veteran patients is inconsistent with clinical guidelines, with the majority of initiating patients provided with insufficient duration. Enhanced management of patients with characteristics associated with shorter persistence, including cancer and multi-morbidities, may improve antidepressant use. Content Type Journal ArticlePages 1-7DOI 10.1007/s00228-011-1087-3Authors Christine Y. Lu, Department of Population Medicine, Harvard Medical School and the Harvard Pilgrim Health Care Institute, 133 Brookline Ave, 6th Floor, Boston, MA 02215, USAElizabeth Roughead, Quality Use of Medicines and Pharmacy Research Centre, Sansom Institute, University of South Australia, GPO Box 2471, Adel... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=4993758 Tue, 28 Jun 2011 15:51:44 +0100 4993758 http://www.medworm.com/index.php?rid=4986342&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd1660gv674mw0341%2F Conclusions  Our findings suggest that the tolerability of these drugs differs substantially. Content Type Journal ArticlePages 1-3DOI 10.1007/s00228-011-1090-8Authors Tara Gomes, The Institute for Clinical Evaluative Sciences, Toronto, ON, CanadaDavid N. Juurlink, The Institute for Clinical Evaluative Sciences, Toronto, ON, CanadaMuhammad M. Mamdani, The Institute for Clinical Evaluative Sciences, Toronto, ON, Canada Journal European Journal of Clinical PharmacologyOnline ISSN 1432-1041Print ISSN 0031-6970 (Source: European Journal of Clinical Pharmacology) European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=4986342 Mon, 27 Jun 2011 18:11:24 +0100 4986342 http://www.medworm.com/index.php?rid=4970517&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx5581471830t625m%2F Conclusions  Poor agreement was found among five sources listing warfarin interactions. Potentially severe clinical consequences might occur due to these discrepant recommendations. Finally, the lack of standard terminology and clinical guidance, as well as the possible inaccuracy of severity ratings and documentation might contribute to heterogeneous procedures in clinical practice. Content Type Journal ArticlePages 1-8DOI 10.1007/s00228-011-1086-4Authors Maria A. P. Martins, Faculdade de Medicina, Hospital das Clínicas, Universidade Federal de Minas Gerais, Av. Prof. Alfredo Balena, 190, Belo Horizonte, MG 30130-100, BrazilPaula P. S. Carlos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos, 6627, Pampulha, Belo Horizont... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=4970517 Thu, 23 Jun 2011 16:33:34 +0100 4970517 http://www.medworm.com/index.php?rid=4970518&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw169w13743t0363l%2F Content Type Journal ArticlePages 1-2DOI 10.1007/s00228-011-1085-5Authors Knut Tore Lappegård, Division of Medicine, Nordland Hospital, 8092 Bodø, NorwayElisabet Nordmo, RELIS Nord-Norge (Regional medicines information centre of North Norway), University Hospital of North Norway, Tromsø, Norway Journal European Journal of Clinical PharmacologyOnline ISSN 1432-1041Print ISSN 0031-6970 (Source: European Journal of Clinical Pharmacology) European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=4970518 Thu, 23 Jun 2011 16:33:26 +0100 4970518 http://www.medworm.com/index.php?rid=4970520&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F266444359533h445%2F Conclusion   CYP3A5 genotype may explain variation in tacrolimus disposition early after transplant in pediatric kidney recipients, independent of age-related variation. In contrast, in pediatric liver recipients, variation in tacrolimus disposition appears related to age and ABCB1 genotype. These findings illustrate the importance of the interplay among age, genotype, and transplant organ on tacrolimus disposition. Content Type Journal ArticlePages 1-11DOI 10.1007/s00228-011-1083-7Authors Saskia N. de Wildt, Intensive Care and Department of Pediatric Surgery, Erasmus MC Sophia Children’s Hospital, Sk3140, Dr. Molewaterplein 60, 3015 GJ Rotterdam, The NetherlandsRon H. N. van Schaik, Pharmacogenomics Core Laboratory, Department of Clinical Chemistry, Erasmus MC, ... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=4970520 Wed, 22 Jun 2011 15:59:06 +0100 4970520 http://www.medworm.com/index.php?rid=4970519&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2q77ht0371h640p2%2F Conclusion  Our results indicate that a combination of several intervention measures seems to have been successful. While it seems like the implementation of the guidelines alone had some effect, there was an additional effect when reimbursement measures were implemented. Furthermore, the practice seemed to have affected the adoption of the national CVRM guideline as the variation initially increased after the guideline implementation. By including information on both the proportion of simvastatin prescribed and interpractice variation, we achieved a more complete evaluation of how simvastatin prescription developed over time and how it was related to the different measures taken. Content Type Journal ArticlePages 1-7DOI 10.1007/s00228-011-1082-8Authors Henrik Ohl... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=4970519 Wed, 22 Jun 2011 15:59:06 +0100 4970519 http://www.medworm.com/index.php?rid=4970521&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb3h4772wq564887g%2F Conclusions   CYP2C9 polymorphisms leading to decreased enzyme activity show a modest impact on the risk of mild hypoglycaemia attacks during oral antidiabetic treatment, with a significant association in patients treated with gliclazide. Content Type Journal ArticlePages 1-7DOI 10.1007/s00228-011-1078-4Authors Osman Gökalp, Medical Faculty, Department of Pharmacology, Dicle University, Diyarbakir, TurkeyArzu Gunes, Department of Medical Sciences, Clinical Pharmacology, Uppsala University, Uppsala, SwedenHakan Çam, Medical Faculty, Department of Internal Medicine, Süleyman Demirel University, Isparta, TurkeyErkan Cure, Medical Faculty, Department of Internal Medicine, Süleyman Demirel University, Isparta, TurkeyOsman Aydın, Medical Faculty, Department of Interna... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=4970521 Tue, 21 Jun 2011 18:33:20 +0100 4970521 http://www.medworm.com/index.php?rid=4970522&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F261746m81183501n%2F Discussion  We here report a case of near-fatal isolated tramadol cardiotoxicity. Because of the inhibition of norepinephrine reuptake, excessive blood epinephrine levels in this CYP2D6R UM patient following excessive tramadol ingestion could explain the observed strong myocardial stunning. This patient admitted intermittent tramadol consumption to gain a “high” sensation. In patients with excessive morphinomimetic effects, levels of tramadol and its main metabolite M1could be measured, ideally combined with CYP2D6 genotyping, to identify individuals at risk of tramadol-related cardiotoxicity. Tramadol treatment could be optimized in these at-risk individuals, consequently improving patient outcome and safety. Content Type Journal ArticlePages 1-4DOI 10.1007/s00... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=4970522 Tue, 21 Jun 2011 18:33:19 +0100 4970522 http://www.medworm.com/index.php?rid=4970523&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr020337671305u20%2F Conclusions  TNF-α blockers have better therapeutic effects on moderate or severe UC, which shows little response to conventional therapy. TNF-α blockers can induce short-term response, maintain long-term clinical response and clinical relief, and decrease the colectomy rate and the severe adverse reaction rate, but they fail to improve quality of life and mucosal healing. Content Type Journal ArticlePages 1-8DOI 10.1007/s00228-011-1079-3Authors Xuan Huang, Department of Gastroenterology, the First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, 310006 ChinaBin Lv, Department of Gastroenterology, the First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, 310006 ChinaHai-feng Jin, Department of Gastroenterology, the First Affil... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=4970523 Tue, 21 Jun 2011 18:33:18 +0100 4970523 http://www.medworm.com/index.php?rid=4970524&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F085007815pn0284w%2F Conclusion  The present study revealed that plasma concentration of PAX, 5-HTTLPR genotype, -1019C/G 5-HT1A genotype, PAS score at baseline, and adverse effects may influence the therapeutic response to PAX in patients with PD. Content Type Journal ArticlePages 1-9DOI 10.1007/s00228-011-1073-9Authors Shin Ishiguro, Department of Psychiatry, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu-machi, Shimotsuga, Tochigi 321–0293, JapanTakashi Watanabe, Department of Psychiatry, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu-machi, Shimotsuga, Tochigi 321–0293, JapanMikito Ueda, Department of Psychiatry, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu-machi, Shimotsuga, Tochigi 321–0293, JapanYoshinori S... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=4970524 Tue, 21 Jun 2011 18:00:30 +0100 4970524 http://www.medworm.com/index.php?rid=4970525&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fqn224023423m6143%2F Conclusion  PIM prescription in the elderly is a major and worrying problem in France. As in other countries, recent accessibility of the National Insurance Healthcare database makes it possible to create local indicators that the regional health agencies could use to manage public health policy in closer alignment to the needs of the patients within each French region. Content Type Journal ArticlePages 1-9DOI 10.1007/s00228-011-1077-5Authors B. Bongue, Centre Technique d’Appui et de Formation des Centres d’Examens de Santé de l’Assurance Maladie (CETAF), Saint-Etienne, FranceM. L. Laroche, Service de Pharmacologie, Toxicologie et Pharmacovigilance, Hôpital Dupuytren, Centre Hospitalier Universitaire, 87042 Limoges Cedex, FranceS. Gutton, Centre Technique d�... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=4970525 Tue, 21 Jun 2011 16:43:59 +0100 4970525 http://www.medworm.com/index.php?rid=4946663&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx8r2g3h05376t7xv%2F Conclusions  A higher percentage of very frequent users was detected in patients already in treatment compared with new users. Moreover, the percentage of nonnegligible triptan recipients were in age groups for which the drug is not recommended by the product label (≤18 years and >65) and who had cardiovascular coprescriptions suggestive of vasoconstrictive risk. Content Type Journal ArticlePages 1-7DOI 10.1007/s00228-011-1076-6Authors Chiara Biagi, Department of Pharmacology, University of Bologna, Via Irnerio 48, 40126 Bologna, ItalyElisabetta Poluzzi, Department of Pharmacology, University of Bologna, Via Irnerio 48, 40126 Bologna, ItalyGiuseppe Roberto, Department of Pharmacology, University of Bologna, Via Irnerio 48, 40126 Bologna, ItalyAurora Puccini... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=4946663 Wed, 15 Jun 2011 05:47:06 +0100 4946663 http://www.medworm.com/index.php?rid=4946664&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fun408r6675038073%2F Conclusions  CDSS identified a large number of drug interactions in surgical discharge medication, but according to ZHIAS criteria only a minor fraction of these appeared to involve a substantial risk to the patient. CDSS should therefore aim at reducing over-alerting and improve usability in order to become more efficacious in terms of the prevention of adverse drug events in clinical practice. Content Type Journal ArticlePages 1-10DOI 10.1007/s00228-011-1081-9Authors Thomas Frölich, Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Rämistrasse 100, 8091 Zurich, SwitzerlandOlesya Zorina, Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Rämistrasse 100, 8091 Zurich, SwitzerlandAndrea O. Fontana, Departme... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=4946664 Tue, 14 Jun 2011 05:56:06 +0100 4946664 http://www.medworm.com/index.php?rid=4937252&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk734063435675757%2F Conclusions  The high rate of age-related off-label prescribing for neonates calls for urgent action from medical professionals and others to reinforce effective and safe pharmacotherapy for this age group. The existing SPCs should be regularly updated and more closely harmonised to each other. Content Type Journal ArticlePages 1-9DOI 10.1007/s00228-011-1072-xAuthors Jana Lass, Institute of Microbiology, Tartu University, Tartu, EstoniaRuth Käär, Tallinn Children’s Hospital, Tallinn, EstoniaKaarin Jõgi, Department of Pharmacy, Tartu University, Tartu, EstoniaHeili Varendi, Tartu University Clinics Children’s Hospital, Tartu, EstoniaTuuli Metsvaht, Tartu University Clinics Children’s Hospital, Tartu, EstoniaIrja Lutsar, Institute of Microbiology, Tartu Univer... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=4937252 Sat, 11 Jun 2011 06:30:35 +0100 4937252 http://www.medworm.com/index.php?rid=4923343&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx21780t77n818234%2F Conclusions  Wide between-subject variability in drug exposure suggests a role for TDM. LSSs can accurately estimate both total and free prednisolone AUC0–12. However, given the poor correlation observed between the two parameters, our data suggest that free prednisolone LSSs may be preferable. Content Type Journal ArticlePages 1-10DOI 10.1007/s00228-011-1071-yAuthors Katherine A. Barraclough, Department of Nephrology, University of Queensland at the Princess Alexandra Hospital, Level 2, ARTS Building, Ipswich Road, Woolloongabba, Brisbane, 4102 QLD, AustraliaNicole M. Isbel, Department of Nephrology, University of Queensland at the Princess Alexandra Hospital, Level 2, ARTS Building, Ipswich Road, Woolloongabba, Brisbane, 4102 QLD, AustraliaBrett C. McWhinney, Dep... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=4923343 Wed, 08 Jun 2011 15:45:05 +0100 4923343 http://www.medworm.com/index.php?rid=4923342&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff28675vw26652615%2F Content Type Journal ArticlePages 1-3DOI 10.1007/s00228-011-1075-7Authors Hua-Wen Xin, Department of Clinical Pharmacology, Wuhan General Hospital of Guangzhou Command, 627 Wuluo Road, Wuhan, 430070 ChinaQing Li, Department of Clinical Pharmacology, Wuhan General Hospital of Guangzhou Command, 627 Wuluo Road, Wuhan, 430070 ChinaXiao-Chun Wu, Department of Clinical Pharmacology, Wuhan General Hospital of Guangzhou Command, 627 Wuluo Road, Wuhan, 430070 ChinaYan He, Department of Clinical Pharmacology, Wuhan General Hospital of Guangzhou Command, 627 Wuluo Road, Wuhan, 430070 ChinaAi-Rong Yu, Department of Clinical Pharmacology, Wuhan General Hospital of Guangzhou Command, 627 Wuluo Road, Wuhan, 430070 ChinaLei Xiong, Department of Clinical Pharmacology, Wuhan General Hospital of Guangzh... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=4923342 Wed, 08 Jun 2011 15:45:05 +0100 4923342 http://www.medworm.com/index.php?rid=4923344&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6q87214844736m88%2F Conclusions  No effects of maternal codeine intake during pregnancy were observed on infant survival or congenital malformation rate. Our findings are reassuring; however, the association with acute Cesarean delivery and postpartum hemorrhage may justify a certain level of caution when administering codeine toward the end of pregnancy. Content Type Journal ArticlePages 1-9DOI 10.1007/s00228-011-1069-5Authors Kateřina Nezvalová-Henriksen, Department of Social Pharmacy, School of Pharmacy, Faculty of Mathematics and Natural Sciences, University of Oslo, Sem Sælands vei 3, 0316 Oslo, NorwayOlav Spigset, Department of Clinical Pharmacology, St Olav’s University Hospital, 7006 Trondheim, NorwayHedvig Nordeng, Department of Social Pharmacy, School of Pharmacy, Faculty... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=4923344 Wed, 08 Jun 2011 15:45:03 +0100 4923344 http://www.medworm.com/index.php?rid=4913845&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq73475227534x728%2F Conclusion  Dopaminergic agonists, benzodiazepines and serotoninergic antidepressants are the main pharmacological classes able to induce aggressive behaviour. This study also emphasises the putative role of other drugs less known to be involved in such ADR. Content Type Journal ArticlePages 1-10DOI 10.1007/s00228-011-1067-7Authors Nadège Rouve, Service de Pharmacologie Clinique, Centre Midi-Pyrénées de PharmacoVigilance, de Pharmacoépidémiologie et d’Information sur les Médicaments, Centre Hospitalier Universitaire de Toulouse, Toulouse, FranceHaleh Bagheri, Service de Pharmacologie Clinique, Centre Midi-Pyrénées de PharmacoVigilance, de Pharmacoépidémiologie et d’Information sur les Médicaments, Centre Hospitalier Universitaire de Toulouse, Toulouse, ... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=4913845 Tue, 07 Jun 2011 15:50:50 +0100 4913845 http://www.medworm.com/index.php?rid=4913844&cid=s_33420_13_f&fid=33420&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F17w5617t0930601q%2F Conclusions  Genetic polymorphism in SLCO1B1 does not affect pharmacokinetics of UDCA, suggesting that OATP1B1 is not rate-limiting to the hepatic uptake of therapeutic UDCA. Further studies are required to clarify the mechanisms by which UDCA increases the plasma concentrations of endogenous bile acids. Content Type Journal ArticlePages 1-9DOI 10.1007/s00228-011-1070-zAuthors Xiaoqiang Xiang, Department of Clinical Pharmacology, University of Helsinki and HUSLAB, Helsinki University Central Hospital, PO Box 705, 00029 HUS Helsinki, FinlandJuha Vakkilainen, Department of Clinical Pharmacology, University of Helsinki and HUSLAB, Helsinki University Central Hospital, PO Box 705, 00029 HUS Helsinki, FinlandJanne T. Backman, Department of Clinical Pharmacology, Universit... European Journal of Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=4913844 Tue, 07 Jun 2011 15:50:50 +0100 4913844