MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'European Journal of Endocrinology' source. Wed, 08 Feb 2012 15:08:56 +0100 http://www.medworm.com/index.php?rid=5644284&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22285701%26dopt%3DAbstract Conclusions: The result suggested that there was a significant linear trend for increasing AHI1 gene copy number frequencies with increasing BMI. PMID: 22285701 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5644284 Fri, 27 Jan 2012 05:00:00 +0100 5644284 http://www.medworm.com/index.php?rid=5644283&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22285702%26dopt%3DAbstract Conclusions. Increased RHR, a reflection of sympathetic nerve activity, is associated with an increased risk for T2DM in patients with manifest vascular diseases, particularly in middle-aged patients. PMID: 22285702 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5644283 Fri, 27 Jan 2012 05:00:00 +0100 5644283 http://www.medworm.com/index.php?rid=5644287&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22275471%26dopt%3DAbstract Conclusion: GH administration in abdominally obese premenopausal women exerts beneficial effects on body composition and cardiovascular risk markers, but is associated with a decrease in glucose tolerance in a minority of women. PMID: 22275471 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5644287 Tue, 24 Jan 2012 05:00:00 +0100 5644287 http://www.medworm.com/index.php?rid=5644286&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22275472%26dopt%3DAbstract Conclusion: The proteins identified confirm previous findings in thyroid proteomics, and suggest additional proteins as dysregulated in thyroid tumors. PMID: 22275472 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5644286 Tue, 24 Jan 2012 05:00:00 +0100 5644286 http://www.medworm.com/index.php?rid=5644285&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22275473%26dopt%3DAbstract Discussion: The vitamin D receptor (VDR) and vitamin D metabolizing enzymes are found in reproductive tissues of women and men. VDR knockout mice have significant gonadal insufficiency, decreased sperm count and motility, and histological abnormalities of testis, ovary and uterus. Moreover, we present evidence that vitamin D is involved in female reproduction including in-vitro fertilization (IVF) outcome (clinical pregnancy rates) and polycystic ovary syndrome (PCOS). In PCOS women, low 25-hydroxyvitamin D (25(OH)D) levels are associated with obesity, metabolic and endocrine disturbances and vitamin D supplementation might improve menstrual frequency and metabolic disturbances in those women. Moreover, vitamin D might influence steroidogenesis of sex hormones (estradiol and progesterone) ... European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5644285 Tue, 24 Jan 2012 05:00:00 +0100 5644285 http://www.medworm.com/index.php?rid=5627194&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22267278%26dopt%3DAbstract Conclusions. Patterns of increasing subclinical hypercortisolism in adrenal adenomas are associated with increased prevalence of adverse metabolic and cardiovascular outcomes, independently of other potential risk factors. PMID: 22267278 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5627194 Fri, 20 Jan 2012 05:00:00 +0100 5627194 http://www.medworm.com/index.php?rid=5627193&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22267279%26dopt%3DAbstract Conclusion: Echocardiography can be useful in diagnosing subclinical central hypothyroidism in patients with hypothalamic-pituitary disease. PMID: 22267279 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5627193 Fri, 20 Jan 2012 05:00:00 +0100 5627193 http://www.medworm.com/index.php?rid=5627192&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22267280%26dopt%3DAbstract Conclusions:Men with T2DM have higher serum sclerostin levels than healthy controls and these levels further increase after treatment with PIO, which is also associated with increased serum CTX. These findings suggest that increased sclerostin production may be involved in the pathogenesis of increased skeletal fragility in patients with T2DM in general, and may specifically contribute to the detrimental effect of TZDs on bone. PMID: 22267280 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5627192 Fri, 20 Jan 2012 05:00:00 +0100 5627192 http://www.medworm.com/index.php?rid=5627196&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22258111%26dopt%3DAbstract Conclusion: Adult patients with GHD following treatment for paediatric CD and NFPA have long-term adverse consequences. Despite more severe hypopituitarism in CO-NFPA, patients with CO-CD have more frequently compromised final stature. PMID: 22258111 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5627196 Wed, 18 Jan 2012 05:00:00 +0100 5627196 http://www.medworm.com/index.php?rid=5627195&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22258112%26dopt%3DAbstract Conclusion.Overall persistence at 1 year was low, but intermittent regimens were associated with higher persistence rates, along with women who had therapy monitoring. PMID: 22258112 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5627195 Wed, 18 Jan 2012 05:00:00 +0100 5627195 http://www.medworm.com/index.php?rid=5607254&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22253400%26dopt%3DAbstract ConclusionConfirmatory testing performed while the patient is on chronic therapy without diuretics and aldosterone antagonists can confirm the diagnosis of primary aldosteronism, provided serum aldosterone remains markedly elevated at the end of saline infusion. PMID: 22253400 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5607254 Tue, 17 Jan 2012 05:00:00 +0100 5607254 http://www.medworm.com/index.php?rid=5607256&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22250073%26dopt%3DAbstract ConclusionThe confirmation of early though subtle features of the metabolic syndrome and changes in body composition among LBW rural Indians supports the idea of foetal programming contributing to the risk of T2D and the metabolic syndrome. Although the alterations in the absolute sense appear mild, factors such as urbanisation and aging may further aggravate and unmask the metabolic abnormalities, linking T2D and the metabolic syndrome with LBW in the Indian population. PMID: 22250073 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5607256 Mon, 16 Jan 2012 05:00:00 +0100 5607256 http://www.medworm.com/index.php?rid=5607255&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22250074%26dopt%3DAbstract Conclusion: Quality of life is impaired in association with the need for prolonged postoperative therapy by somatostatin analogs in patients with acromegaly despite similar IGF-1 levels. PMID: 22250074 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5607255 Mon, 16 Jan 2012 05:00:00 +0100 5607255 http://www.medworm.com/index.php?rid=5607257&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22247018%26dopt%3DAbstract Conclusions: In the growth plate, GH may compensate for decreased local T3 effects on longitudinal bone growth; however, GH does not appear to compensate for the effects of T3 on bone maturation. We believe the present case has important implications for understanding the mechanism of thyroid hormone and GH on longitudinal bone growth and maturation. PMID: 22247018 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5607257 Fri, 13 Jan 2012 05:00:00 +0100 5607257 http://www.medworm.com/index.php?rid=5607260&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22247015%26dopt%3DAbstract Conclusion: In men treated for pituitary insufficiency, previous CRT is associated with a higher visceral to subcutaneous fat ratio. PMID: 22247015 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5607260 Thu, 12 Jan 2012 05:00:00 +0100 5607260 http://www.medworm.com/index.php?rid=5607259&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22247016%26dopt%3DAbstract Conclusions: Macroprolactinaemia may develop prior to middle age and is likely a chronic condition leading to hyperprolactinaemia. PMID: 22247016 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5607259 Thu, 12 Jan 2012 05:00:00 +0100 5607259 http://www.medworm.com/index.php?rid=5607258&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22247017%26dopt%3DAbstract In conclusion, this pregnant patient presented with PTHrP-associated hypercalcemia, presumably of placental origin. Delivery resulted in prompt reduction of serum calcium levels and a transient "hungry bone" syndrome. PMID: 22247017 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5607258 Thu, 12 Jan 2012 05:00:00 +0100 5607258 http://www.medworm.com/index.php?rid=5607261&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22236473%26dopt%3DAbstract ConclusionsIn summary, 45,X/46,XY children born with ambiguous genitalia and raised as boys have an altered pubertal course and impaired fertility associated with adult short stature, which should therefore be taken into consideration for the management of these patients. PMID: 22236473 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5607261 Wed, 11 Jan 2012 05:00:00 +0100 5607261 http://www.medworm.com/index.php?rid=5580281&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22223701%26dopt%3DAbstract Conclusions: The association study of the ACE I/D polymorphism in PCOS women demonstrates an increase in the DI genotype incidence, and an association of the II genotype with IR. PMID: 22223701 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5580281 Thu, 05 Jan 2012 05:00:00 +0100 5580281 http://www.medworm.com/index.php?rid=5580280&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22223702%26dopt%3DAbstract Conclusions: PCOS patients suffer from a systemic inflammatory status that induces erythrocyte membrane alterations. Treatment with MYO is effective in reducing hormonal, metabolic and oxidative abnormalities in PCOS patients by improving insulin resistance. PMID: 22223702 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5580280 Thu, 05 Jan 2012 05:00:00 +0100 5580280 http://www.medworm.com/index.php?rid=5568759&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214923%26dopt%3DAbstract Authors: Mul D, Wu S, de Paus R, Oostdijk W, Lankester AC, Duyvenvoorde HV, Ruivenkamp C, Losekoot M, Tol MV, Deluca F, van de Vosse E, Wit JM Abstract Established causes of growth hormone (GH) insensitivity include defects of the GH receptor and of STAT5b. The latter condition is also characterized by severe immunodeficiency. A recent case with short stature, GH resistance and immunodeficiency due to an IκB mutation, suggests that the NF-κB pathway may interact with STAT5b signaling. Here, we present a case of a short child with several congenital anomalies as well as GH insensitivity and mild immunodeficiency associated with a mosaic de novo duplication of chromosome 17q21-25, suggesting that overexpression of one of the duplicated genes may be implicated in GH resistance. In v... European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5568759 Wed, 04 Jan 2012 05:00:00 +0100 5568759 http://www.medworm.com/index.php?rid=5568757&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22219499%26dopt%3DAbstract Conclusions: DEX could effectively improve the function of Treg cells and set up a new balance of T helper 1(Th1)/Th2 in GD patients. This study might help to further understand the immune mechanism of DEX intrathyroid injection the in treatment of GD and facilitate the potential use of the therapy. PMID: 22219499 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5568757 Wed, 04 Jan 2012 05:00:00 +0100 5568757 http://www.medworm.com/index.php?rid=5568758&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214924%26dopt%3DAbstract Conclusions: The newly established thresholds facilitated initial screening for secondary adrenal insufficiency and allowed excellent identification of hypercortisolism. Measurement by an automated immunoassay will allow broader use of salivary cortisol as a diagnostic tool. PMID: 22214924 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5568758 Tue, 03 Jan 2012 05:00:00 +0100 5568758 http://www.medworm.com/index.php?rid=5538943&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22157913%26dopt%3DAbstract Authors: PMID: 22157913 [PubMed - in process] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5538943 Sun, 25 Dec 2011 11:38:28 +0100 5538943 http://www.medworm.com/index.php?rid=5538928&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22193973%26dopt%3DAbstract Conclusions: Tpit, a corticotroph-specific transcription factor, was identified as a target autoantigen in 10.5% of lymphocytic hypophysitis patients. Further autoantigens related to vesicle processing were also identified as potential autoantigens with different immunoreactivity patterns in patients and controls. PMID: 22193973 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5538928 Thu, 22 Dec 2011 05:00:00 +0100 5538928 http://www.medworm.com/index.php?rid=5538934&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22189997%26dopt%3DAbstract Conclusions: despite the in vitro activity, sorafenib plus weekly paclitaxel is an inactive salvage treatment in patients with advanced ACC and should not be recommended. PMID: 22189997 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5538934 Wed, 21 Dec 2011 05:00:00 +0100 5538934 http://www.medworm.com/index.php?rid=5538933&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22189998%26dopt%3DAbstract Conclusions This study establishes that (i) GH response to GHRH+Arg is lower in lipoatrophic HIV-infected women than in healthy matched controls, (ii) BMI more than VAT or trunk fat influences GH peak in this population, and (iii) HIV-infected women with a GH peak below or equal to 7.5 µg/L demonstrate reduced IGF-1, IGFBP-3, BMD and quality of life. PMID: 22189998 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5538933 Wed, 21 Dec 2011 05:00:00 +0100 5538933 http://www.medworm.com/index.php?rid=5538932&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22189999%26dopt%3DAbstract Conclusion: The normal levels of adiponectin, IGFBP-1 and IGFBP-2 in the face of highly elevated insulin levels suggest an impaired ability of insulin to suppress markers of common insulin resistance in carriers of a dominant-negative INSR mutation. However, together with the adaptive increases in IGF-I and IGF-II and a potentially improved distribution of adiponectin multimers these changes may contribute to rescue insulin action in insulin receptor deficient individuals. PMID: 22189999 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5538932 Wed, 21 Dec 2011 05:00:00 +0100 5538932 http://www.medworm.com/index.php?rid=5538931&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22190000%26dopt%3DAbstract Conclusions We observed a significant decrease of FGF21 concentration after an oral fat load. Fasting and postprandial FGF21 levels were closely related to large VLDL and remnants, but not to plasma FFA. Our pilot findings suggest that the postprandial accumulation of TRL remnants and liver fat may modulate postprandial FGF21 levels. PMID: 22190000 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5538931 Wed, 21 Dec 2011 05:00:00 +0100 5538931 http://www.medworm.com/index.php?rid=5538930&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22190001%26dopt%3DAbstract Conclusion: Our data showed that testosterone therapy decreased subcutaneous fat on the abdomen and lower extremities, but had no significant effect on visceral fat. Moreover, adiponectin levels were significantly decreased during testosterone therapy. PMID: 22190001 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5538930 Wed, 21 Dec 2011 05:00:00 +0100 5538930 http://www.medworm.com/index.php?rid=5538929&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22190002%26dopt%3DAbstract Conclusion: Spontaneous and sustained remission of hypercortisolemia is possible in EAS after long-term treatment with steroidogenesis inhibitors; a drug holiday may be warranted during chronic therapy to evaluate for this. The pathophysiology remains unclear but may involve several different mechanisms. PMID: 22190002 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5538929 Wed, 21 Dec 2011 05:00:00 +0100 5538929 http://www.medworm.com/index.php?rid=5538935&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22180452%26dopt%3DAbstract Conclusions: In healthy, young adults, prednisone treatment has significant effects on glucose tolerance and bone formation markers within hours of treatment, in parallel with anti-inflammatory effects, after single doses as low as 10 mg. PMID: 22180452 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5538935 Sat, 17 Dec 2011 05:00:00 +0100 5538935 http://www.medworm.com/index.php?rid=5538942&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22170793%26dopt%3DAbstract Conclusion: A post-receptor IGF-1 insensitivity was characterized in one SRS patient with ICR1 hypomethylation. Albeit our study was based on unique severely affected patient, it raises an intriguing possibility to explain the post-natal growth impairment observed in SRS patients. Analyses of larger cohorts are needed to explore the role of MAPK-pathway defect mediated growth failure in SRS. PMID: 22170793 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5538942 Wed, 14 Dec 2011 05:00:00 +0100 5538942 http://www.medworm.com/index.php?rid=5538941&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22170794%26dopt%3DAbstract Conclusions: Fetuin A levels were elevated in NAFLD. Hepatic expression of fetuin A correlated with key enzymes in glucose and lipid metabolism. Metformin decreased fetuin A levels in vitro. PMID: 22170794 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5538941 Wed, 14 Dec 2011 05:00:00 +0100 5538941 http://www.medworm.com/index.php?rid=5538940&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22170795%26dopt%3DAbstract Conclusions: While the association of IUGR and adult MS, including diabetes, has been well-documented, these subjects did not have typical manifestations of MS. Abnormalities in common components that could result in a combination of IUGR, severe postnatal growth, and insulin resistance have been ruled out. A mutation in an unidentified gene may affect intrauterine and postnatal growth, with insulin resistance directly affected or a result of this growth phenomenon. PMID: 22170795 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5538940 Wed, 14 Dec 2011 05:00:00 +0100 5538940 http://www.medworm.com/index.php?rid=5538939&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22170796%26dopt%3DAbstract We describe an 8-year old girl with autoimmune thyroiditis and severe long standing hypothyroidism presenting with the clinical features of Van Wyk-Grumbach syndrome, a secondary TSH secreting adenoma and hyperprolactinaemia. In addition, this girl presented with microcytic anaemia, elevated ESR and two unusual features - a newly developed streaky hyperpigmented skin lesion and PTH suppression despite vitamin D deficiency. Thyroxine replacement normalized all hormone abnormalities, shrunk the pituitary adenoma within 9 months but the new skin lesion persisted. We review the literature and explore the pathophysiology of known and new features which give rise to speculation indicating stimulation of the FSH G protein coupled receptor by excessive TSH, but LH suppression by hyperprolactinaemi... European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5538939 Wed, 14 Dec 2011 05:00:00 +0100 5538939 http://www.medworm.com/index.php?rid=5538938&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22170797%26dopt%3DAbstract Conclusions: Cold exposure influenced thyroid hormones and thyroglobulin in serum in Arctic populations consistent with consumption of thyroid hormone and higher thyroid hormone turnover. Findings emphasise that changes in thyroid activity are essential in cold adaptation in Arctic residents. PMID: 22170797 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5538938 Wed, 14 Dec 2011 05:00:00 +0100 5538938 http://www.medworm.com/index.php?rid=5538937&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22170798%26dopt%3DAbstract Conclusions: Using a new semi-automated image analysis of hand radiographs, acromegalic patients with long-term disease control appeared to have increased joint spaces of all hand joints. Joint space widths were positively related to disease activity at diagnosis, but not to duration of follow-up, suggesting irreversible cartilage hypertrophy. Irreversible cartilage hypertrophy may partly explain persisting hand complaints, despite long-term disease control. PMID: 22170798 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5538937 Wed, 14 Dec 2011 05:00:00 +0100 5538937 http://www.medworm.com/index.php?rid=5538936&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22170799%26dopt%3DAbstract CONCLUSIONS: These data show that users of several medicines have lower serum 25(OH)D than non-users. Vitamin D supplementation may be considered in patients with chronic use of medicines. PMID: 22170799 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5538936 Wed, 14 Dec 2011 05:00:00 +0100 5538936 http://www.medworm.com/index.php?rid=5538944&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22157069%26dopt%3DAbstract Conclusions: Fertility/fecundity was impaired in CAH males. The frequent occurrence of TARTs resulting in testicular insufficiency appears to be the major cause, but other factors such as elevated fat mass may contribute to a low semen quality. PMID: 22157069 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5538944 Fri, 09 Dec 2011 05:00:00 +0100 5538944 http://www.medworm.com/index.php?rid=5480776&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22143318%26dopt%3DAbstract Conclusion: We found significantly higher active ghrelin levels in SGA preterms than those in AGA preterms and demonstrated a negative correlation between active ghrelin levels and birth weight in preterm infants. This was the first study showing a negative correlation between active ghrelin levels and birth weight in preterm infants. PMID: 22143318 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5480776 Mon, 05 Dec 2011 05:00:00 +0100 5480776 http://www.medworm.com/index.php?rid=5480775&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22143319%26dopt%3DAbstract Conclusions: Sonoelastography may assist in the diagnosis and treatment monitoring of AT, SAT and CAT, as well as in the differentiation of the various types of thyroiditis. PMID: 22143319 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5480775 Mon, 05 Dec 2011 05:00:00 +0100 5480775 http://www.medworm.com/index.php?rid=5480777&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22129891%26dopt%3DAbstract Conclusions Our results confirm that germline CDKN1B mutations may predispose to a human MEN4 condition, and add novel evidence that alteration in the transcription/translation rate of CDKN1B mRNA might be the mechanism implicated in tumor susceptibility. PMID: 22129891 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5480777 Wed, 30 Nov 2011 05:00:00 +0100 5480777 http://www.medworm.com/index.php?rid=5480782&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22127489%26dopt%3DAbstract Conclusion: Resistance of prolactinoma to dopamine agonists is correlated with a reduction in D(2)L isoform mRNA levels. Silencing of the DRD2 gene by methylation in the promoter region is unlikely to play a role in dopamine agonist resistance in prolactinoma. PMID: 22127489 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5480782 Tue, 29 Nov 2011 05:00:00 +0100 5480782 http://www.medworm.com/index.php?rid=5480781&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22127490%26dopt%3DAbstract Conclusions In type 1 diabetes higher serum HMGB1 levels are associated with greater prevalence and severity of albuminuria, though not with eGFR, retinopathy, and CVD. Prospective studies are needed to clarify the causal role of HMGB1, if any, in the pathogenesis of vascular complications in type 1 diabetes. PMID: 22127490 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5480781 Tue, 29 Nov 2011 05:00:00 +0100 5480781 http://www.medworm.com/index.php?rid=5480780&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22127491%26dopt%3DAbstract Conclusion: Ambulatory arterial stiffness indexes are increased in acromegaly independently of blood pressure elevation, and may have an important role in predicting cardiovascular risk in this disease. PMID: 22127491 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5480780 Tue, 29 Nov 2011 05:00:00 +0100 5480780 http://www.medworm.com/index.php?rid=5480779&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22127492%26dopt%3DAbstract Conclusions: Hirsutism and menstrual disorders are common in the obese adolescent girls and the adolescent girls with T1DM. Although hyperandrogenaemia is present in both groups of girls, the androgenic profile of the two groups differ. The hyperandrogenaemia in the obese girls is primarily due to their decreased serum SHBG levels, whereas the hyperandrogenaemia in the girls with T1DM is due to their increased androgen production. PMID: 22127492 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5480779 Tue, 29 Nov 2011 05:00:00 +0100 5480779 http://www.medworm.com/index.php?rid=5480778&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22127493%26dopt%3DAbstract Conclusions: Inhibin pro-αC is produced by the adrenal gland. Differentiation between ADA and ACC by serum inhibin pro-αC is limited, but its levels may constitute a novel tumor marker for ACC. PMID: 22127493 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5480778 Tue, 29 Nov 2011 05:00:00 +0100 5480778 http://www.medworm.com/index.php?rid=5480783&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22113073%26dopt%3DAbstract ConclusionsIn older men, higher IGF-I and an increased ratio of IGF-I/IGFBP3 are associated with AAA, while IGFBP1 is independently associated with increased aortic diameter. Components of the IGF-I system may contribute to, or be a marker for, aortic dilation in ageing men. PMID: 22113073 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5480783 Wed, 23 Nov 2011 05:00:00 +0100 5480783 http://www.medworm.com/index.php?rid=5480810&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22108914%26dopt%3DAbstract Conclusion GDM prevalence was overall 2.4-times higher with the modified IADPSG criteria compared with the WHO criteria. The new criteria identified many subjects with a relatively mild increase in fasting PG, strongly associated with South Asian origin and prepregnant overweight. PMID: 22108914 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5480810 Tue, 22 Nov 2011 05:00:00 +0100 5480810 http://www.medworm.com/index.php?rid=5480784&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22108915%26dopt%3DAbstract Conclusions: Our preliminary data indicate that different estrogen administration routes can influence IGF-1 and IGFBP-1 levels. These findings in patients with hypopituitarism have an impact on their response to treatment with GH, since patients receiving oral estrogen require increased GH dosage. These results suggest that oral estrogens may reduce the beneficial effects of GH replacement on fat and protein metabolism, body composition, and quality of life. PMID: 22108915 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5480784 Tue, 22 Nov 2011 05:00:00 +0100 5480784 http://www.medworm.com/index.php?rid=5480813&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22106341%26dopt%3DAbstract Conclusions: This study shows that GH replacement increases lumbar (L2-L4) spine and femur neck BMD and BMC in younger as well as elderly GHD patients. This supports that long-term GH replacement is useful also in elderly GHD patients. PMID: 22106341 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5480813 Mon, 21 Nov 2011 05:00:00 +0100 5480813 http://www.medworm.com/index.php?rid=5428198&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22096111%26dopt%3DAbstract Conclusions: RT-CGM is more beneficial than SBGM in reducing HbA1c in patients with type 1 diabetes. Further studies are needed to evaluate the efficacy of this system in pediatric population, especially in very young children. PMID: 22096111 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428198 Thu, 17 Nov 2011 05:00:00 +0100 5428198 http://www.medworm.com/index.php?rid=5428197&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22096112%26dopt%3DAbstract Authors: Sathyapalan T, Atkin S Abstract Polycystic ovary syndrome (PCOS) has been associated with increased cardiovascular risk (CVR) markers, but population studies have not clarified if there is an increase in cardiovascular morbidity and mortality. Four different PCOS phenotypes resulted from the Rotterdam criteria that may differ in their CVR potential introducing further complexity. This has led to studies using surrogate CVR markers including biomarkers in blood as well as by imaging such as flow mediated vasodilatation. Insulin resistance in PCOS has been shown to be both peripheral and central insulin resistance. Weight loss has been shown to improve insulin resistance and visceral fat, whilst insulin sensitiser therapies with metformin or thiozolididiones improve insulin... European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428197 Thu, 17 Nov 2011 05:00:00 +0100 5428197 http://www.medworm.com/index.php?rid=5428196&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22096113%26dopt%3DAbstract Conclusions. Children with craniopharyngioma have a decrease in aerobic capacity mainly related to hypothalamic involvement. The hypothalamic factors altering aerobic capacity remain to be determined. PMID: 22096113 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428196 Thu, 17 Nov 2011 05:00:00 +0100 5428196 http://www.medworm.com/index.php?rid=5428202&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22084153%26dopt%3DAbstract Conclusions: We have i) showed that, in obese children, PDE8B is associated with TSH; ii) demonstrated that the interaction between adiposity and PDE8B on TSH is not synergistic, but follows an additive model iii) highlighted the impact of this association in the stratification of the individual risk to have hyperthyrotropinemia. PMID: 22084153 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428202 Mon, 14 Nov 2011 05:00:00 +0100 5428202 http://www.medworm.com/index.php?rid=5428201&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22084154%26dopt%3DAbstract Authors: Taipaleenmäki H, Bjerre L, Chen L, Kauppinen S, Kassem M Abstract Osteoblast differentiation and bone formation (osteogenesis) are regulated by transcriptional and post-transcriptional mechanisms. Recently, a novel class of regulatory factors termed microRNAs has been identified as playing an important role in the regulation of many aspects of osteoblast biology including proliferation, differentiation, metabolism and apoptosis. Also, preliminary data from animal disease models suggest that targeting miRNAs in bone can be a novel approach to increase bone mass. This review highlights the current knowledge of microRNA biology and their role in bone formation and discusses their potential use in future therapeutic applications for metabolic bone diseases. PMID: 22084154... European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428201 Mon, 14 Nov 2011 05:00:00 +0100 5428201 http://www.medworm.com/index.php?rid=5428200&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22084155%26dopt%3DAbstract ConclusionsAdrenal pathology in MEN1 differs from that observed in sporadic incidentalomas. In the absence of relevant symptoms, endocrine biology can be restricted to patients with adrenal tumours and should focus on steroid secretion including the aldosterone-renin system. MEN1 is a high-risk condition for the occurrence of ACCs. It should be considered regardless of the size of the tumour. PMID: 22084155 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428200 Mon, 14 Nov 2011 05:00:00 +0100 5428200 http://www.medworm.com/index.php?rid=5428199&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22084156%26dopt%3DAbstract Conclusion: A single basal lutenizing hormone measurement may be adequate to confirm but not to refute the presence of Central Precocious Puberty in most of the girls who are evaluated for early pubertal signs. PMID: 22084156 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428199 Mon, 14 Nov 2011 05:00:00 +0100 5428199 http://www.medworm.com/index.php?rid=5428203&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22080441%26dopt%3DAbstract Conclusions: In SF-1 mutations, the neonatal phenotype poorly predicts virilization at puberty. Even in poorly virilized cases at birth, male gender assignment may allow spontaneous puberty without signs of hypogonadotropic hypogonadism, and possibly fertility. Patients with SF-1 mutations are at increased risk for malignant germ cell tumors. In case of preserved gonads, early orchidopexy and germ cell tumor screening is warranted. The finding of premalignant and/or malignant changes should prompt gonadectomy -or possibly irradiation. PMID: 22080441 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428203 Fri, 11 Nov 2011 05:00:00 +0100 5428203 http://www.medworm.com/index.php?rid=5428204&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22071311%26dopt%3DAbstract Conclusion: This study showed that there were no significant differences on cognitive performance between the three-, four- and five fields radiotherapy groups and the non-irradiated patient group. Therefore, a dose-response relationship could not be established, even with a radiation dose that was higher on most of the volume of the hippocampus and PFC in case of a 4-fields RT technique compared to the 3- and 5-fields technique. PMID: 22071311 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428204 Wed, 09 Nov 2011 05:00:00 +0100 5428204 http://www.medworm.com/index.php?rid=5428206&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22065856%26dopt%3DAbstract Conclusions: Because, the insulin concentrations, glucose levels, and HOMA-IR exhibited a gradual increase with age that was not related to obesity, our results suggested that the evaluation of insulin resistance in children should be based on percentiles of the HOMA-IR rather than a dichotomous value derived from a single cutoff point. PMID: 22065856 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428206 Mon, 07 Nov 2011 05:00:00 +0100 5428206 http://www.medworm.com/index.php?rid=5428205&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22065857%26dopt%3DAbstract Conclusions DG3173 equalled Octreotide in suppressing GH-secretion in hSA. Since DG3173 suppressed GH in some Octreotide-unresponsive adenomas, its clinical effectiveness will be worth testing. Moreover, its reduced insulin-suppressive potency would make it a valuable alternative to Octreotide. PMID: 22065857 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428205 Mon, 07 Nov 2011 05:00:00 +0100 5428205 http://www.medworm.com/index.php?rid=5428207&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22058081%26dopt%3DAbstract Conclusions GCs for GO are preferentially given iv in Europe. Both oral and ivGC may be associated with severe adverse effects, including fatal cases, which are more frequently reported using daily or alternate day ivGC. IvGC therapy should be undertaken in centers with appropriate expertise. Patients should be carefully evaluated for risk factors before treatment and monitored for side effects, which may be asymptomatic, both during and after treatment. PMID: 22058081 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428207 Fri, 04 Nov 2011 04:00:00 +0100 5428207 http://www.medworm.com/index.php?rid=5383468&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22048963%26dopt%3DAbstract Conclusion: To the best of our knowledge, this is the first case of an adrenal neoplasm combining a primary angiosarcoma and a functioning adrenocortical adenoma. PMID: 22048963 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5383468 Wed, 02 Nov 2011 04:00:00 +0100 5383468 http://www.medworm.com/index.php?rid=5383467&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22048964%26dopt%3DAbstract Conclusion: This study confirms the prognostic value of the combined expression of BUB1B, DLG7 and PINK1 genes in a Brazilian series of adult adrenocortical tumors. Among pediatric ACTs, other molecular predictors of outcome are required. PMID: 22048964 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5383467 Wed, 02 Nov 2011 04:00:00 +0100 5383467 http://www.medworm.com/index.php?rid=5383466&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22048965%26dopt%3DAbstract Conclusions: The A3669G polymorphism of the GR gene plays a protective role in patients with CS, attenuating the effects of glucocorticoid excess on glucose metabolism as shown by their reduced risk of diabetes. PMID: 22048965 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5383466 Wed, 02 Nov 2011 04:00:00 +0100 5383466 http://www.medworm.com/index.php?rid=5383465&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22048966%26dopt%3DAbstract We report the results of a survey undertaken in 2010 to determine the use of the IGFGT amongst members of the European Society for Paediatric Endocrinology (ESPE) to evaluate suspected GHI. The literature surrounding the usefulness and limitations of the IGFGT are reviewed, and recommendations provided for its use.Of 112 pediatric endocrinologists from 30 countries who responded to the survey, 91 (81%) reported that they had used the IGFGT in the previous 2 years; >10 IGFGT protocols were used. The IGFGT impacted treatment decisions for 97% of the respondents, and was a prerequisite for recombinant human IGF-1 (rhIGF-1) treatment for 45% of respondents. From a literature review, sensitivity of the IGFGT was evaluated as 80-85% in molecularly proven cases of GHI; specificity was ≤97%, ... European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5383465 Wed, 02 Nov 2011 04:00:00 +0100 5383465 http://www.medworm.com/index.php?rid=5383464&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22048967%26dopt%3DAbstract Conclusions: Postmenopausal women with severe osteoporosis previously treated with bisphosphonates had a significant reduction in the incidence of fractures compared with the first 6 months of therapy, a reduction in back pain and an improvement in HRQoL during up to 18 months of teriparatide treatment. These outcomes were still evident for at least 18 months after teriparatide was discontinued. The results should be interpreted in the context of an uncontrolled, observational study in a routine clinical setting. PMID: 22048967 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5383464 Wed, 02 Nov 2011 04:00:00 +0100 5383464 http://www.medworm.com/index.php?rid=5383463&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22048968%26dopt%3DAbstract Conclusions: Secondary and compensated hypogonadism were associated with vitamin D deficiency and the clinical significance of this relationship warrants further investigation. PMID: 22048968 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5383463 Wed, 02 Nov 2011 04:00:00 +0100 5383463 http://www.medworm.com/index.php?rid=5383461&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22048969%26dopt%3DAbstract ConclusionLAR octreotide is equally efficient and tolerated as subcutaneous octreotide in diazoxide-unresponsive HI patients and contributes to a clear simplification of their medical care. PMID: 22048969 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5383461 Wed, 02 Nov 2011 04:00:00 +0100 5383461 http://www.medworm.com/index.php?rid=5383438&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22048970%26dopt%3DAbstract Conclusion:We report here that in a group of X-ALD/AMN married adult men, we did not find a significant decrease in fertility compared with the Polish population (18.2% vs 15%). PMID: 22048970 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5383438 Wed, 02 Nov 2011 04:00:00 +0100 5383438 http://www.medworm.com/index.php?rid=5383436&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22048971%26dopt%3DAbstract Conclusion: Employing a high-dose strategy at the time of mitotane initiation enabled therapeutic plasma levels of mitotane to be reached within 1 month in 27% of the total group of patients. If this strategy is adopted, we suggest that mitotane dose is readjusted according to plasma mitotane levels at one or/and two months and patient tolerance. PMID: 22048971 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5383436 Wed, 02 Nov 2011 04:00:00 +0100 5383436 http://www.medworm.com/index.php?rid=5383435&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22048972%26dopt%3DAbstract Conclusions. NR5A2 modulates gene expression in osteoblasts and some allelic variants are associated with bone mass in Spanish postmenopausal women. PMID: 22048972 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5383435 Wed, 02 Nov 2011 04:00:00 +0100 5383435 http://www.medworm.com/index.php?rid=5383434&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22048973%26dopt%3DAbstract Conclusion: Changing serum medium-chain acylcarnitine levels may affect circulating acyl ghrelin levels, suggesting that acyl-CoA is the substrate for ghrelin acylation. PMID: 22048973 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5383434 Wed, 02 Nov 2011 04:00:00 +0100 5383434 http://www.medworm.com/index.php?rid=5383433&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22048974%26dopt%3DAbstract Authors: Devries JH Abstract In a recent issue of the Journal of Clinical Endocrinology and Metabolism, an Endocrine Society Clinical Practice Guideline on Continuous Glucose Monitoring is published, co-sponsored by the European Society of Endocrinology. Such a guideline is a necessary step in the maturation of any new technology. This commentary tries to delineate where we stand some ten years after the first retrospective continuous glucose monitoring device entered the market from a European perspective. PMID: 22048974 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5383433 Wed, 02 Nov 2011 04:00:00 +0100 5383433 http://www.medworm.com/index.php?rid=5383432&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22048975%26dopt%3DAbstract In conclusion, we demonstrated that detoxification genes and apoptotic and cell-cycle control genes are involved in the susceptibility of sporadic MTC and may modulate the susceptibility to the disease. PMID: 22048975 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5383432 Wed, 02 Nov 2011 04:00:00 +0100 5383432 http://www.medworm.com/index.php?rid=5348160&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22023791%26dopt%3DAbstract Conclusions: Our meta-analysis showed that hypothyroidism is not associated with increased risk for breast cancer and thyroid hormone replacement therapy does not reduce breast cancer prevalence however the heterogeneity of the studies analyzed precludes firm conclusions. PMID: 22023791 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5348160 Mon, 24 Oct 2011 04:00:00 +0100 5348160 http://www.medworm.com/index.php?rid=5348159&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22023792%26dopt%3DAbstract Conclusions: There is wide variation in the clinical practice relating to the treatment and screening of hypothyroidism during pregnancy in Europe. PMID: 22023792 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5348159 Mon, 24 Oct 2011 04:00:00 +0100 5348159 http://www.medworm.com/index.php?rid=5348161&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22019891%26dopt%3DAbstract Conclusions: Appliance of BBR improved some of the metabolic and hormonal derangements in a group of treated Chinese women with PCOS. Main effects could be related to the changes of body composition in obesity and dyslipidemia. Further controlled studies are needed for the assessment of the potential favourable metabolic effects of BBR in women with PCOS. PMID: 22019891 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5348161 Fri, 21 Oct 2011 04:00:00 +0100 5348161 http://www.medworm.com/index.php?rid=5348162&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22009494%26dopt%3DAbstract CONCLUSIONS_Morphologies of the glucose curve seem reflecting different metabolic phenotypes of insulin action and secretion, particularly when combined with morphologies of insulin curve or time of glucose peak. Such findings may deserve validation in cohort study, in which glucose metabolism would be estimated by using gold-standard techniques. PMID: 22009494 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5348162 Tue, 18 Oct 2011 04:00:00 +0100 5348162 http://www.medworm.com/index.php?rid=5348166&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22004906%26dopt%3DAbstract Conclusions: Lower levels of circulating IGF1 and IGFBP3 were independently associated with ARDS case status. Furthermore, lower levels were associated with mortality among ARDS cases. This data supports a role of the IGF pathway in ARDS. PMID: 22004906 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5348166 Mon, 17 Oct 2011 04:00:00 +0100 5348166 http://www.medworm.com/index.php?rid=5348165&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22004907%26dopt%3DAbstract Conclusion: US alone could not differentiate ectopia and athyreosis, whereas scintigraphy alone is also prone to mistakes in newborns and young ages. Dual thyroid imaging is important for precise structural definition of thyroid dysgenesis. PMID: 22004907 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5348165 Mon, 17 Oct 2011 04:00:00 +0100 5348165 http://www.medworm.com/index.php?rid=5348164&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22004908%26dopt%3DAbstract Conclusions. Neon when compared to children, showed higher UAG and lower AG levels. The AG/UAG ratio showed a very different profile in Neon, being lower than in NW and OB children, thus suggesting a different metabolic function for the two forms for the neonatal age. Further studies are needed to clarify the exact role of the different ghrelin forms in neonates. PMID: 22004908 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5348164 Mon, 17 Oct 2011 04:00:00 +0100 5348164 http://www.medworm.com/index.php?rid=5348163&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22004909%26dopt%3DAbstract Conclusions: Patients with CS have increased myocardial fibrosis, which is related to LV systolic and diastolic dysfunction. Successful treatment of CS normalizes the extent of myocardial fibrosis. Therefore, myocardial fibrosis appears to be an important factor in the development and potential regression of CS cardiomyopathy. PMID: 22004909 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5348163 Mon, 17 Oct 2011 04:00:00 +0100 5348163 http://www.medworm.com/index.php?rid=5317276&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21993154%26dopt%3DAbstract Conclusion: Withdrawal of SA is possible in a small but distinct subset of patients, particularly in those who are very well controlled on relatively low doses administered at long intervals. PMID: 21993154 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5317276 Wed, 12 Oct 2011 04:00:00 +0100 5317276 http://www.medworm.com/index.php?rid=5317283&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21984611%26dopt%3DAbstract Conclusion: Our findings suggest that in PHPT, FGF23 levels are increased independently of 1,25(OH)2D levels. The more pronounced negative relationship between FGF23 and 1,25(OH)2D in the presence of high circulating PTH levels suggests that the increase in FGF23 levels may be an adaptive mechanism to counteract the PTH-induced increase in 1,25(OH)2D levels, although not completely overriding it. PMID: 21984611 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5317283 Fri, 07 Oct 2011 04:00:00 +0100 5317283 http://www.medworm.com/index.php?rid=5317291&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21976623%26dopt%3DAbstract Authors: Chisalita SI, Dahlström U, Arnqvist HJ, Alehagen U Abstract AbstractObjective. There are conflicting results regarding the association of circulating insulin-like growth factor-1 (IGF-1) with cardiovascular (CV) morbidity and mortality. We assessed the relationship between IGF-1 levels and heart failure (HF), ischemic heart disease (IHD) and CV mortality in an elderly population taking into account the possible impact of angiotensin- converting enzyme inhibitors (ACE-inhibitors).Design and methods. 851 persons aged 66-81 years, in a rural Swedish municipality were evaluated by medical history, clinical examination, electrocardiography, echocardiography and fasting plasma samples. They were then followed for 8 years.Results and conclusion. Patients on ACE-inhibitors had el... European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5317291 Wed, 05 Oct 2011 04:00:00 +0100 5317291 http://www.medworm.com/index.php?rid=5284257&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21969522%26dopt%3DAbstract Conclusions: LC-MS/MS, compared with a labor intensive extraction RIA, shows good precision, sensitivity and high accuracy for measuring female T, DHEA and AD concentrations under various clinical conditions. LC-MS/MS therefore represents a convenient and reliable assay for both clinical and research purposes in conditions where androgen measurement in women is required. PMID: 21969522 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284257 Mon, 03 Oct 2011 04:00:00 +0100 5284257 http://www.medworm.com/index.php?rid=5284256&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21969523%26dopt%3DAbstract Conclusions: MetS is highly prevalent in GHD and is associated with a higher prevalence ratio for comorbidities. The presence of MetS in GHD may therefore contribute to the increased risk of cardiovascular morbidity and mortality found in these patients. PMID: 21969523 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284256 Mon, 03 Oct 2011 04:00:00 +0100 5284256 http://www.medworm.com/index.php?rid=5284272&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21724839%26dopt%3DAbstract Conclusion In patients diagnosed with hyperthyroidism, mortality is increased by ∼20%. Future studies need to address the cause of hyperthyroidism, impact of type of therapy, time dependency, as well as the potential influence of confounding or genetic susceptibility before the question of causality can be answered. PMID: 21724839 [PubMed - in process] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284272 Sat, 01 Oct 2011 04:00:00 +0100 5284272 http://www.medworm.com/index.php?rid=5284271&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21753069%26dopt%3DAbstract Conclusion In this cohort of obese children, PAPPA serum levels correlated significantly with other cardiovascular risk factors. The lack of a direct correlation between PAPPA and IMT suggests that the described association of atherosclerotic plaques and increased PAPPA levels might reflect an indirect mechanism of PAPPA with cardiovascular risk factors such as serum lipids rather than a direct effect on the vasculature. PMID: 21753069 [PubMed - in process] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284271 Sat, 01 Oct 2011 04:00:00 +0100 5284271 http://www.medworm.com/index.php?rid=5284270&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21768248%26dopt%3DAbstract Conclusions This study does not support disadvantageous effects of subclinical thyroid disorders on physical or cognitive function, depression, or mortality in an older population. PMID: 21768248 [PubMed - in process] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284270 Sat, 01 Oct 2011 04:00:00 +0100 5284270 http://www.medworm.com/index.php?rid=5284269&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21775498%26dopt%3DAbstract Conclusion Fetal growth characteristics strongly influence infant growth rates. A higher PWV, which generally occurs in the first month after birth, was associated with an increased risk of overweight and obesity at 4 years of age. Longer follow-up studies are necessary to determine how fetal and infant growth patterns affect the risk of disease in later life. PMID: 21775498 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284269 Sat, 01 Oct 2011 04:00:00 +0100 5284269 http://www.medworm.com/index.php?rid=5284268&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21788424%26dopt%3DAbstract Conclusions Our results indicate that the 'idiopathic' PAIS-like phenotype may in some cases be related to EDC contamination during fetal life. PMID: 21788424 [PubMed - in process] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284268 Sat, 01 Oct 2011 04:00:00 +0100 5284268 http://www.medworm.com/index.php?rid=5284267&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21803798%26dopt%3DAbstract Conclusions This study provides the first report of a deletion in the HMGA2 gene that might be related to IGHD. We suggest that this gene is investigated as a second screening in patients with a classical IGHD phenotype in which mutations in classical candidate genes have been excluded. PMID: 21803798 [PubMed - in process] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284267 Sat, 01 Oct 2011 04:00:00 +0100 5284267 http://www.medworm.com/index.php?rid=5284266&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21810856%26dopt%3DAbstract Conclusions Our results demonstrate a previously undetected strong association of two SSTR5 SNPs with acromegaly. The data also suggest a possible involvement of SSTR5 variants in decreased suppression of GH production and increased tumor proliferation. PMID: 21810856 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284266 Sat, 01 Oct 2011 04:00:00 +0100 5284266 http://www.medworm.com/index.php?rid=5284265&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21813593%26dopt%3DAbstract Conclusions Our results implicate peripheral deiodination in the peculiar hormonal constellation of MCT8-deficient patients. Other MCT8-deficient patients should be closely monitored for potential thyroid abnormalities. PMID: 21813593 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284265 Sat, 01 Oct 2011 04:00:00 +0100 5284265 http://www.medworm.com/index.php?rid=5284264&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21824900%26dopt%3DAbstract Conclusion Our findings would support the involvement of AVP-AQP2 axis, interacting with the RAS, in the progression of IgAN and candidate AQP2 as a possible novel marker of the disease. PMID: 21824900 [PubMed - in process] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284264 Sat, 01 Oct 2011 04:00:00 +0100 5284264 http://www.medworm.com/index.php?rid=5284263&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21957122%26dopt%3DAbstract Authors: Romijn JA, Strasburger CJ PMID: 21957122 [PubMed - in process] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284263 Sat, 01 Oct 2011 04:00:00 +0100 5284263 http://www.medworm.com/index.php?rid=5284262&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21964959%26dopt%3DAbstract Conclusion: Men diagnosed with idiopathic 46 XY DSD during childhood are at high risk of testicular insufficiency and persistent micropenis, and this should be taken into account during follow-up. PMID: 21964959 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284262 Fri, 30 Sep 2011 04:00:00 +0100 5284262 http://www.medworm.com/index.php?rid=5284261&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21964960%26dopt%3DAbstract Conclusions: This is the first large-scale, single-center, clinical study to evaluate sGHD in patients after cure of acromegaly by surgery alone. This study found that sGHD occurred in approximately 9% of patients and assessment of GHD by stimulation tests is critical after successful treatment of acromegaly by surgery. PMID: 21964960 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284261 Fri, 30 Sep 2011 04:00:00 +0100 5284261 http://www.medworm.com/index.php?rid=5284260&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21964961%26dopt%3DAbstract Authors: Bollerslev J, Marcocci C, Henriques MS, Nordenström J, Bouillon R, Mosekilde L Abstract Management of patients with mild primary hyperparathyroidism (PHPT) has been widely discussed because most patients today do not have specific symptoms. While surgery is always an option, the recommendations for treatment have shifted, which mostly reflects changes in clinical practice. In this review, we aimed to evaluate evidence for the current recommendations concerning operation versus observation, repletion with vitamin D, and alternative medical management.Surgery is followed by normalisation of calcium and PTH and a decrease in bone turnover followed by an increase in bone mass. It is not known what the consequences would be for the frequency of fractures. Randomised studies ha... European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284260 Thu, 29 Sep 2011 04:00:00 +0100 5284260 http://www.medworm.com/index.php?rid=5284259&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21964962%26dopt%3DAbstract Conclusions: Heavy smoking was significantly associated with T2DM, and this association was moderated by CYP2A6 genotype and mediated by serum cotinine, abdominal obesity, insulin resistance and insulin secretion. PMID: 21964962 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284259 Thu, 29 Sep 2011 04:00:00 +0100 5284259 http://www.medworm.com/index.php?rid=5284258&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21964963%26dopt%3DAbstract Conclusions: Our results endorse the hypothesis that decreased expression of adiponectin together with a selective reduction of its high molecular weight oligomers contribute to the worsening of insulin resistance and its metabolic complications in DM1 patients. These findings suggest that adiponectin and high molecular weight oligomers may serve as biomarkers, and are promising therapeutic agents for insulin resistance and its consequences in DM1. PMID: 21964963 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284258 Thu, 29 Sep 2011 04:00:00 +0100 5284258 http://www.medworm.com/index.php?rid=5268615&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21951700%26dopt%3DAbstract Conclusions. Significant differences in serum steroid hormone levels were observed in middle-aged African-Caribbean and European men. Whether such differences could contribute to ethnic differences in disease risk in adult men remains to be investigated. Some steroids, such as bioavailable testosterone, 4-androstenedione, 5-androstenediol, and estrone deserve particular attention. PMID: 21951700 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5268615 Tue, 27 Sep 2011 04:00:00 +0100 5268615 http://www.medworm.com/index.php?rid=5268614&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21951701%26dopt%3DAbstract Conclusion: We have identified a novel MRAP mutation where disruption of the intron 3 splice-site results in a prematurely terminated translation product. This protein (if produced) would lack the transmembrane domain that is essential for MC2R interaction. We predict that this would cause complete lack of ACTH response thus explaining the early presentation in this case. PMID: 21951701 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5268614 Tue, 27 Sep 2011 04:00:00 +0100 5268614 http://www.medworm.com/index.php?rid=5249679&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21937504%26dopt%3DAbstract Conclusions:Non-European ethnicity, gestational insulin use, family history of T2DM and elevated BMI were associated with persistent dysglycemia after GDM. Breast-feeding may confer beneficial metabolic effects after GDM and should be encouraged. PMID: 21937504 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5249679 Wed, 21 Sep 2011 04:00:00 +0100 5249679 http://www.medworm.com/index.php?rid=5249678&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21937505%26dopt%3DAbstract Conclusion: High FLI levels are a common finding in obese PCOS women and are closely linked to MS. FLI calculation might be a useful tool for identifying PCOS patients at high risk for metabolic and hepatic disturbances. PMID: 21937505 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5249678 Wed, 21 Sep 2011 04:00:00 +0100 5249678 http://www.medworm.com/index.php?rid=5249680&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21930715%26dopt%3DAbstract Authors: Vaag A, Lund SS Abstract This review addresses the apparent disconnect between international guideline recommendations, real-life clinical practice and the results of clinical trials, with regard to the initiation of insulin using basal (long-acting) or premixed insulin analogues in patients with type 2 diabetes (T2D). English language guidelines vary considerably with respect to recommended glycaemic targets, the selection of human versus analogue insulin, and choice of insulin regimen. Randomized trials directly comparing insulin initiation between basal and premixed analogues are scarce, and hard endpoint outcome data is inadequate. The evidence presented suggests that the major component of the HbA1c not being attained in every day clinical practice may be a result of ... European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5249680 Mon, 19 Sep 2011 04:00:00 +0100 5249680 http://www.medworm.com/index.php?rid=5221687&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21914670%26dopt%3DAbstract Conclusions: The patients with SCS present disturbances in endogenous anticoagulant system defined as PC, FPS activity and TM concentration. This finding suggests an impact of mild autonomic cortisol overproduction on coagulation system. PMID: 21914670 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5221687 Tue, 13 Sep 2011 04:00:00 +0100 5221687 http://www.medworm.com/index.php?rid=5221688&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21908653%26dopt%3DAbstract Conclusion: The incidence of hyperthyroidism in Sweden is in a lower range compared to international reports. Patients with hyperthyroidism had GD in 75% and 20% of them had thyroid associated eye symptoms/-signs at diagnosis. The observed geographical differences require further studies. PMID: 21908653 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5221688 Fri, 09 Sep 2011 04:00:00 +0100 5221688 http://www.medworm.com/index.php?rid=5221690&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21903895%26dopt%3DAbstract Conclusions: Oestradiol, SHBG, IGF-I and PTH contribute significantly to the regulation / rate of bone turnover in middle-aged and older European men. Higher rates of bone remodeling are negatively associated with male bone health. PMID: 21903895 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5221690 Thu, 08 Sep 2011 04:00:00 +0100 5221690 http://www.medworm.com/index.php?rid=5221689&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21903896%26dopt%3DAbstract Conclusion: Diabetics had a lower LVEF than non-diabetics. This difference could be demonstrated regardless of CAD extent and might in part explain their generally worse cardiac survival compared to non-diabetic patients on an epidemiological level. In addition, this finding points to other discussed mechanisms than CAD lowering LVEF in diabetic patients. PMID: 21903896 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5221689 Thu, 08 Sep 2011 04:00:00 +0100 5221689 http://www.medworm.com/index.php?rid=5221691&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21900406%26dopt%3DAbstract Conclusion:These results suggest that patients with NFAs need to be closely monitored following surgery particularly those with post operative tumour remnants. With 20% of relapse occurring after 10 years, follow up surveillance needs to be continued beyond this time. PMID: 21900406 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5221691 Wed, 07 Sep 2011 04:00:00 +0100 5221691 http://www.medworm.com/index.php?rid=5221695&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21896619%26dopt%3DAbstract Conclusion: Liquorice and in particular GFJ increased cortisol available to tissues in the hours following oral CA administration. Both patients and physicians should be aware of these interactions, and we recommend that circulating levels of cortisol should be monitored in habitual users. PMID: 21896619 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5221695 Tue, 06 Sep 2011 04:00:00 +0100 5221695 http://www.medworm.com/index.php?rid=5221694&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21896620%26dopt%3DAbstract Authors: Jafri M, Maher E Abstract Phaeochromocytoma is a rare, usually benign, tumour predominantly managed by endocrinologists. Over the last decade, major advances have been made in understanding the molecular genetic basis of adrenal and extra-adrenal phaeochromocytoma (also referred to as adrenal phaeochromocytoma (aPCA) and extra-adrenal functional paraganglioma (eFPGL)). In contrast to the previously held belief that only 10% of cases had a genetic component, currently about one third of all aPCA/eFPGL cases are thought to be attributable to germline mutations in at least nine genes (NF1, RET, SDHA, SDHB, SDHC, SDHD, TMEM127, MAX, and VHL). Recognition of inherited cases of aPCA/eFPGL is critical for optimal patient management. Thus, the identification of a germline mutation... European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5221694 Tue, 06 Sep 2011 04:00:00 +0100 5221694 http://www.medworm.com/index.php?rid=5221693&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21896621%26dopt%3DAbstract Conclusion We identified a 70 kb deletion encompassing exons 2-6 of the MCT8 gene in our AHDS patient. Both LT4 and LT3 administration had no therapeutic effect. Alternatively, treatment of AHDS patients with thyroid hormone analogs should be considered. PMID: 21896621 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5221693 Tue, 06 Sep 2011 04:00:00 +0100 5221693 http://www.medworm.com/index.php?rid=5221692&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21896622%26dopt%3DAbstract Conclusions: Androgen-secreting tumors are clinically difficult to discriminate from other causes of postmenopausal hyperandrogenism. Testosterone and FSH were the 2 discriminative markers in a multivariate analysis. Ovarian and adrenal tumors were detected by imaging studies. However, ovarian non tumoral causes of hyperandrogenism may be difficult to detect with conventional histology. PMID: 21896622 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5221692 Tue, 06 Sep 2011 04:00:00 +0100 5221692 http://www.medworm.com/index.php?rid=5221698&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21890650%26dopt%3DAbstract Authors: Lenders J Abstract A phaeochromocytoma in a pregnant patient is one of the most threatening medical conditions for both mother, fetus and physician. Although extraordinarily rare with a frequency of 0.002% of all pregnancies, this tumour is notorious for its devastating consequences. As in non-pregnant patients, signs and symptoms are quite variable but not specific with hypertension as one of the most prominent signs. Confusion with the much more prevalent forms of pregnancy-related hypertension is the main cause of overlooking the diagnosis. If undiagnosed, maternal and fetal mortality is around 50%. Conversely, early detection and proper treatment during pregnancy decreases maternal and fetal mortality to less than 5% and 15% respectively. For the biochemical diagnosis ... European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5221698 Fri, 02 Sep 2011 04:00:00 +0100 5221698 http://www.medworm.com/index.php?rid=5221697&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21890651%26dopt%3DAbstract Authors: Schlumberger M, Sherman S Abstract Patients with advanced thyroid cancer may benefit from l-thyroxine treatment at doses that suppress serum TSH level, local treatment interventions and radioiodine therapy. In those patients who are refractory to radioiodine therapy and in whom progressive disease has been documented, the efficacy of cytotoxic chemotherapy is poor. Encouraging results have been obtained with the use of kinase inhibitors that should be offered as first line treatment, preferably in the context of a prospective trial. PMID: 21890651 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5221697 Fri, 02 Sep 2011 04:00:00 +0100 5221697 http://www.medworm.com/index.php?rid=5221696&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21890652%26dopt%3DAbstract Conclusion: The presence of type 1 diabetes in a FDR is associated with a decreased risk of DKA at diagnosis. The rate of DKA seems to be higher in children with lower HLA-conferred risk for type 1 diabetes. PMID: 21890652 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5221696 Fri, 02 Sep 2011 04:00:00 +0100 5221696 http://www.medworm.com/index.php?rid=5195586&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21885674%26dopt%3DAbstract Conclusion: A positive response to Vasopressin analogs and/or CRH tests occurs early in recurrence, followed by an increase in midnight cortisol, while UC elevation is a later stage. PMID: 21885674 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5195586 Wed, 31 Aug 2011 23:00:00 +0100 5195586 http://www.medworm.com/index.php?rid=5195585&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21885675%26dopt%3DAbstract Conclusions: We demonstrate that lipocalin-2 is not an independent predictor of metabolic and cardiovascular risk factors in young men cross-sectionally or prospectively. PMID: 21885675 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5195585 Wed, 31 Aug 2011 23:00:00 +0100 5195585 http://www.medworm.com/index.php?rid=5180411&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21878580%26dopt%3DAbstract Conclusions: Excess iodate induced hypothyroidism in some participants and hyperthyroidism in others. Most abnormalities disappeared after 4 weeks. Excess iodate reduced WBGPx activity and resulted in smaller increases in WBGPx after selenium supplementation. PMID: 21878580 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5180411 Mon, 29 Aug 2011 23:00:00 +0100 5180411 http://www.medworm.com/index.php?rid=5180412&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21873490%26dopt%3DAbstract Conclusion: Elevated serum FGF23 concentrations are independently associated with prevalent cardiovascular disease in older community-dwelling women. Further studies are needed to elucidate the potential biological mechanisms by which FGF23 may be involved in the pathogenesis of cardiovascular disease. PMID: 21873490 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5180412 Thu, 25 Aug 2011 23:00:00 +0100 5180412 http://www.medworm.com/index.php?rid=5180414&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21868601%26dopt%3DAbstract Conclusions The prevalence of different features of cardiomyopathy is 3.3-14.2 times higher in the acromegalic than in the non-acromegalic population. The major determinant of cardiomyopathy is disease duration. PMID: 21868601 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5180414 Wed, 24 Aug 2011 23:00:00 +0100 5180414 http://www.medworm.com/index.php?rid=5180413&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21868602%26dopt%3DAbstract CONCLUSIONS: This skeletal case, and other ancient ones are discussed, in order to better describe the history of the disease, and the possibilities of diagnosis. PMID: 21868602 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5180413 Wed, 24 Aug 2011 23:00:00 +0100 5180413 http://www.medworm.com/index.php?rid=5160403&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21865408%26dopt%3DAbstract Conclusions: Plasma levels of omentin-1 were reduced in non-obese women with PCOS and NGT. Postprandial hyperinsulinemia and hyperglycemia contributed more to lower omentin-1 levels than did fasting values in the setting of PCOS. Increased androgen levels contributed to decreased omentin-1 levels in women with PCOS. PMID: 21865408 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5160403 Tue, 23 Aug 2011 23:00:00 +0100 5160403 http://www.medworm.com/index.php?rid=5160402&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21865409%26dopt%3DAbstract Conclusion: Growth hormone therapy in adults with confirmed GH deficiency reduces weight and body fat, increases lean body mass and increases edema and joint stiffness. Most trials demonstrated improvement in quality of life measures. PMID: 21865409 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5160402 Tue, 23 Aug 2011 23:00:00 +0100 5160402 http://www.medworm.com/index.php?rid=5160404&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21862666%26dopt%3DAbstract Conclusion: Even though QoL may improve substantially after surgery, former PHPT patients still have reduced QoL compared to healthy controls. PMID: 21862666 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5160404 Mon, 22 Aug 2011 23:00:00 +0100 5160404 http://www.medworm.com/index.php?rid=5160406&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21856788%26dopt%3DAbstract Conclusion GH assessment during a standardized aerobic exercise of moderate intensity is a reliable test with high diagnostic accuracy in predicting severe GHD in adult individuals. Based on the current findings an exercise duration of 60 minutes appears to be sufficient for diagnostic purposes. PMID: 21856788 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5160406 Thu, 18 Aug 2011 23:00:00 +0100 5160406 http://www.medworm.com/index.php?rid=5160405&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21856789%26dopt%3DAbstract Conclusion: Several tests with reasonable diagnostic accuracy are available for the diagnosis of growth hormone deficiency in adults. The supporting evidence, however, is at high risk of bias (due to heterogeneity, methodological limitations, and imprecision). PMID: 21856789 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5160405 Thu, 18 Aug 2011 23:00:00 +0100 5160405 http://www.medworm.com/index.php?rid=5142968&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21852390%26dopt%3DAbstract This article summarizes the molecular and cell biology of the RANKL/RANK system and critically reviews preclinical and clinical studies that have established denosumab as a promising novel therapy for metabolic and malignant bone diseases. We will discuss the potential indications for denosumab along with a critical review of safety and analyze its potential within the concert of established therapies. This article is based on the presentation for the European Journal of Endocrinology Prize Lecture 2010 by L C Hofbauer at the European Congress of Endocrinology Meeting at Prague, Czech Republic. PMID: 21852390 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5142968 Wed, 17 Aug 2011 23:00:00 +0100 5142968 http://www.medworm.com/index.php?rid=5142967&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21852391%26dopt%3DAbstract Conclusions. Low T and higher E2 correlate with increased risk of CVD and CV mortality. TRT in hypogonadism moderates metabolic components associated with CV risk. Whether low T is just an association with CV risk, or an actual cause and effect relationship, awaits further studies. PMID: 21852391 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5142967 Wed, 17 Aug 2011 23:00:00 +0100 5142967 http://www.medworm.com/index.php?rid=5142969&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21846663%26dopt%3DAbstract Conclusions: p.Q258X is the most common StAR mutation in Korea. A previously reported c.653C>T variant was found to cause aberrant splicing at the mRNA level, resulting in perturbation of StAR function. The c.745-6_810del mutation also resulted in aberrant splicing. PMID: 21846663 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5142969 Mon, 15 Aug 2011 23:00:00 +0100 5142969 http://www.medworm.com/index.php?rid=5142970&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21835764%26dopt%3DAbstract Authors: Kotnik P, Fischer-Posovszky P, Wabitsch M Abstract Adipose tissue is an endocrine organ, secreting biologically active factors called adipokines that act both locally and on distant tissues. Adipokines have an important role in the development of obesity related co-morbidities not only in adults but also in children and adolescents. Retinol binding protein 4 (RBP4) is a recently identified adipokine suggested to link obesity with its co-morbidities, especially insulin resistance, type 2 diabetes and certain components of the metabolic syndrome. However, data, especially results from the clinical studies, are conflicting. In this review we summarize up-to-date knowledge on RBP4s role in obesity, development of insulin resistance and T2D. Special attention is devoted to stud... European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5142970 Tue, 09 Aug 2011 23:00:00 +0100 5142970 http://www.medworm.com/index.php?rid=5112649&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21824900%26dopt%3DAbstract Conclusion: our findings would support the involvement of AVP-AQP2 axis, interacting with the RAS, in the progression of IgAN, and candidate AQP2 as a possible novel marker of the disease. PMID: 21824900 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5112649 Sun, 07 Aug 2011 23:00:00 +0100 5112649 http://www.medworm.com/index.php?rid=5112650&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21821631%26dopt%3DAbstract Conclusion: Increased degree of mineralization associated with lower crystallinity and microhardness in ALN long-term-treated PMOP women suggests that ALN could alter the quality of bone matrix. The study also suggested that after three years of treatment, the changes in material properties are not dependent of the treatment duration. Further studies are requested to assess the short-term (< 3 years) effects of bisphosphonates on bone intrinsic properties. PMID: 21821631 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5112650 Thu, 04 Aug 2011 23:00:00 +0100 5112650 http://www.medworm.com/index.php?rid=5112651&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21813593%26dopt%3DAbstract Conclusions: Our results implicate peripheral deiodination in the peculiar hormonal constellation of MCT8-deficient patients. Other MCT8-deficient patients should be closely monitored for potential thyroid abnormalities. PMID: 21813593 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5112651 Tue, 02 Aug 2011 23:00:00 +0100 5112651 http://www.medworm.com/index.php?rid=5112652&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21810856%26dopt%3DAbstract Conclusions: Our results demonstrate a previously undetected strong association of two SSTR5 SNPs with acromegaly. The data also suggest a possible involvement of SSTR5 variants in decreased suppression of growth hormone (GH) production and increased tumor proliferation. PMID: 21810856 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5112652 Mon, 01 Aug 2011 23:00:00 +0100 5112652 http://www.medworm.com/index.php?rid=5112654&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21803798%26dopt%3DAbstract Conclusions: This study provides the first report of a deletion in the HMGA2 gene that might be related to IGHD. We suggest that this gene be investigated as a second screening in patients with a classical IGHD phenotype in whom mutations in classical candidate genes have been excluded. PMID: 21803798 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5112654 Thu, 28 Jul 2011 23:00:00 +0100 5112654 http://www.medworm.com/index.php?rid=5112659&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21798957%26dopt%3DAbstract Conclusions: According to current results, acute phase reactants such as IL-6 and CFB are associated with fasting glucagon in metabolically compromised subjects. This suggests that glucagon may be behind the association between inflammatory and metabolic parameters in obesity-associated chronic low-grade inflammation. PMID: 21798957 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5112659 Wed, 27 Jul 2011 23:00:00 +0100 5112659 http://www.medworm.com/index.php?rid=5112658&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21798958%26dopt%3DAbstract Conclusions: Patients after long-term remission of CS report more negative illness perceptions compared to patients with other acute or chronic conditions. Further research is needed to assess whether QoL in CS can be improved by addressing these illness perceptions, for example by a self-management intervention program. PMID: 21798958 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5112658 Wed, 27 Jul 2011 23:00:00 +0100 5112658 http://www.medworm.com/index.php?rid=5112657&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21798959%26dopt%3DAbstract Conclusion: We herein present a novel data indicating vaspin levels are neither altered in overt and subclinical hypothyroidism nor have a relationship with features of insulin resistance in hypothyroid patients. PMID: 21798959 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5112657 Wed, 27 Jul 2011 23:00:00 +0100 5112657 http://www.medworm.com/index.php?rid=5112656&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21798960%26dopt%3DAbstract Conclusions In contrast to previous reports we found no evidence that skeletal muscle mitochondrial respiration is reduced in skeletal muscle of women with PCOS compared to control subjects. Furthermore, mitochondrial content did not differ between our control and PCOS groups. These results question the causal relationship between reduced mitochondrial function and skeletal muscle insulin resistance in PCOS. PMID: 21798960 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5112656 Wed, 27 Jul 2011 23:00:00 +0100 5112656 http://www.medworm.com/index.php?rid=5112655&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21798961%26dopt%3DAbstract Conclusion: Plasma adrenomedullin correlates with plasma IL-6 level, consistent with its role in inflammation. It is related to an SNP common in Chinese, independent of other covariates. Adrenomedullin genotype should be included in future studies of cardiovascular risk prediction. PMID: 21798961 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5112655 Wed, 27 Jul 2011 23:00:00 +0100 5112655 http://www.medworm.com/index.php?rid=5112660&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21788424%26dopt%3DAbstract Conclusions: Our results indicate that the "idiopathic" PAIS-like phenotype may in some cases be related to EDC contamination during fetal life. PMID: 21788424 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5112660 Sun, 24 Jul 2011 23:00:00 +0100 5112660 http://www.medworm.com/index.php?rid=5112661&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21778250%26dopt%3DAbstract Conclusion The present work indicates a potential link between SPARC and the pathogenesis of T2DM. PMID: 21778250 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5112661 Wed, 20 Jul 2011 23:00:00 +0100 5112661 http://www.medworm.com/index.php?rid=5112663&cid=s_37945_15_f&fid=37945&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21775498%26dopt%3DAbstract Conclusion: Fetal growth characteristics strongly influence infant growth rates. A higher PWV, which generally occurs in the first month after birth, was associated with an increased risk of overweight and obesity at 4 years of age. Longer follow-up studies are necessary to determine how fetal and infant growth patterns affect the risk of disease in later life. PMID: 21775498 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology) European Journal of Endocrinology journals http://www.medworm.com/rss/comments.php?id=5112663 Tue, 19 Jul 2011 23:00:00 +0100 5112663