European Journal of Heart Failure via MedWorm.com MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'European Journal of Heart Failure' source. Sun, 21 Mar 2010 14:01:15 +0100 Haemodynamic effects of acute intravenous metoprolol in apical ballooning syndrome with dynamic left ventricular outflow tract obstruction http://www.medworm.com/index.php?rid=3273608&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F3%2F305%3Frss%3D1 We present a case of apical ballooning syndrome complicated by dynamic LVOTO, treated with metoprolol. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3273608 Mon, 15 Feb 2010 14:51:49 +0100 3273608 Extracorporeal membrane oxygenation as a rescue of intractable ventricular fibrillation and bridge to heart transplantation http://www.medworm.com/index.php?rid=3273607&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F3%2F301%3Frss%3D1 We report a case of persistent ventricular fibrillation (VF) that was rescued by insertion of peripheral veno-arterial ECMO during cardiopulmonary resuscitation, which provided support for 30 h of continuous VF and subsequently permitted urgent heart transplantation. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3273607 Mon, 15 Feb 2010 14:51:48 +0100 3273607 Effects of alagebrium, an advanced glycation end-product breaker, in patients with chronic heart failure: study design and baseline characteristics of the BENEFICIAL trial http://www.medworm.com/index.php?rid=3273606&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F3%2F294%3Frss%3D1 Conclusion The BENEFICIAL study is a proof-of-concept study that will provide new data on the efficacy and safety of the AGE crosslink breaker alagebrium in systolic HF patients. EudraCT number of this trial is NCT00516646. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3273606 Mon, 15 Feb 2010 14:51:48 +0100 3273606 Prevalence and pharmacological treatment of left-ventricular dysfunction in patients undergoing vascular surgery http://www.medworm.com/index.php?rid=3273605&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F3%2F288%3Frss%3D1 Conclusions This study demonstrates a high prevalence of LV dysfunction in vascular surgery patients and under-utilization of ESC recommended pharmacological treatment. Standard pre-operative evaluation of LV function could be argued based on our results to reduce this observed care gap. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3273605 Mon, 15 Feb 2010 14:51:48 +0100 3273605 Decreased likelihood of response to cardiac resynchronization in patients with severe heart failure http://www.medworm.com/index.php?rid=3273604&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F3%2F283%3Frss%3D1 Conclusion The results show that non-responder patients have a more advanced stage of the disease, which suggests that CRT should be indicated earlier in the disease process. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3273604 Mon, 15 Feb 2010 14:51:48 +0100 3273604 Right ventricular dysfunction is an independent predictor for mortality in ST-elevation myocardial infarction patients presenting with cardiogenic shock on admission http://www.medworm.com/index.php?rid=3273603&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F3%2F276%3Frss%3D1 Conclusion In STEMI patients presenting with CS on admission and treated with primary PCI, RV dysfunction as assessed by echocardiography is an independent predictor for long-term mortality. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3273603 Mon, 15 Feb 2010 14:51:48 +0100 3273603 Cardiac Raynaud's phenomenon induced by cold provocation as a predictor of long-term left ventricular dysfunction and remodelling in systemic sclerosis: 7-year follow-up study http://www.medworm.com/index.php?rid=3273602&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F3%2F268%3Frss%3D1 Conclusion This study documents for the first time that severe C-Raynaud is a strong long-term predictor of systolic LV dysfunction in SSc patients. Detection of C-Raynaud is clinically important for identifying SSc patients at high risk of cardiac deterioration at latent stage. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3273602 Mon, 15 Feb 2010 14:51:48 +0100 3273602 The dynamic assessment of right-ventricular function and its relation to exercise capacity in heart failure http://www.medworm.com/index.php?rid=3273601&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F3%2F260%3Frss%3D1 Conclusions Right-ventricular function (whether at rest or during stress tests) was not significantly associated with exercise capacity in our patients with HF. In contrast, systolic and, to a greater extent, diastolic LV parameters during the stress tests emerged as the most important indicators linked to exercise capacity in HF. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3273601 Mon, 15 Feb 2010 14:51:48 +0100 3273601 Apolipoproteins in the discrimination of atherosclerotic burden and cardiac function in patients with stable coronary artery disease http://www.medworm.com/index.php?rid=3273600&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F3%2F254%3Frss%3D1 Conclusion Apo AI levels are a consistent discriminator of atherosclerotic burden among patients with stable CAD. However, heart failure presents an element of confounding in the diagnostic and prognostic utility of Apo monitoring among these patients. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3273600 Mon, 15 Feb 2010 14:51:48 +0100 3273600 A meta-analysis of erythropoiesis-stimulating agents in anaemic patients with chronic heart failure http://www.medworm.com/index.php?rid=3273599&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F3%2F249%3Frss%3D1 Conclusion This meta-analysis suggests a symptomatic improvement in anaemic patients with CHF receiving ESA. However, a non-significant reduction in all-cause mortality in the ESA treatment group compared with the control group was observed. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3273599 Mon, 15 Feb 2010 14:51:48 +0100 3273599 Characteristics, outcomes, and predictors of mortality at 3 months and 1 year in patients hospitalized for acute heart failure http://www.medworm.com/index.php?rid=3273598&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F3%2F239%3Frss%3D1 Conclusion Early and late mortality differ between de novo AHF and ADCHF and between clinical classes of AHF. EHFS II identifies clinical risk markers and demonstrates the importance of a thorough characterization of AHF populations according to history and clinical presentation. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3273598 Mon, 15 Feb 2010 14:51:48 +0100 3273598 Long-term association between self-reported signs and symptoms and heart failure hospitalizations: the Atherosclerosis Risk In Communities (ARIC) Study http://www.medworm.com/index.php?rid=3273597&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F3%2F232%3Frss%3D1 Conclusion In a population-based cohort, self-reported Gothenburg criteria items were associated with hospitalized HF over a prolonged follow-up time. The association was also consistent across groups defined by sex and race, suggesting that this simple score deserves further study as a screening tool for the identification of individuals at high risk of HF in resource-limited settings. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3273597 Mon, 15 Feb 2010 14:51:48 +0100 3273597 Replacement and reactive myocardial fibrosis in idiopathic dilated cardiomyopathy: comparison of magnetic resonance imaging with right ventricular biopsy http://www.medworm.com/index.php?rid=3273596&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F3%2F227%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3273596 Mon, 15 Feb 2010 14:51:48 +0100 3273596 Mechanism of the inhibitory effect of atorvastatin on endoglin expression induced by transforming growth factor-{beta}1 in cultured cardiac fibroblasts http://www.medworm.com/index.php?rid=3273595&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F3%2F219%3Frss%3D1 Conclusion Atorvastatin inhibits endoglin expression through the inhibition of PI-3 kinase, Akt, and Smad3 phosphorylation, and reduced Smad3/4 binding activity and endoglin promoter activity in cardiac fibroblasts. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3273595 Mon, 15 Feb 2010 14:51:48 +0100 3273595 Assist devices in the new decade: from technical developments to political decisions http://www.medworm.com/index.php?rid=3273594&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F3%2F217%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3273594 Mon, 15 Feb 2010 14:51:48 +0100 3273594 Should erythropoietin treatment in chronic heart failure be haemoglobin targeted? http://www.medworm.com/index.php?rid=3273593&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F3%2F215%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3273593 Mon, 15 Feb 2010 14:51:48 +0100 3273593 Red cell distribution width in chronic heart failure: a new independent marker for prognosis? http://www.medworm.com/index.php?rid=3273592&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F3%2F213%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3273592 Mon, 15 Feb 2010 14:51:48 +0100 3273592 Impact of T-wave amplitude on circadian variation in T-wave alternans http://www.medworm.com/index.php?rid=3182940&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F2%2F209%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3182940 Mon, 18 Jan 2010 18:16:39 +0100 3182940 Haemodialysis, not ultrafiltration, can correct hyponatraemia in heart failure http://www.medworm.com/index.php?rid=3182939&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F2%2F208-a%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3182939 Mon, 18 Jan 2010 18:16:39 +0100 3182939 T-wave alternans in patients with congestive heart failure and sleep apnoea http://www.medworm.com/index.php?rid=3182938&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F2%2F208%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3182938 Mon, 18 Jan 2010 18:16:39 +0100 3182938 Pregnancy outcome in patients with complex pulmonary atresia: case report and review of the literature http://www.medworm.com/index.php?rid=3182937&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F2%2F202%3Frss%3D1 We report here on the outcome of pregnancy in a woman, aged 36, with complex pulmonary atresia in whom palliative operation had been performed at the age of 23. We review the medical literature on pregnancy course as well as maternal and foetal outcome in cases involving this maternal congenital heart disease. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3182937 Mon, 18 Jan 2010 18:16:39 +0100 3182937 Clinical trials update from the American Heart Association meeting 2009: HEAAL, FAIR-HF, J-CHF, HeartMate II, PACE and a meta-analysis of dose-ranging studies of beta-blockers in heart failure http://www.medworm.com/index.php?rid=3182936&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F2%2F197%3Frss%3D1 This article provides information and a commentary on trials relevant to the pathophysiology, prevention, and treatment of heart failure presented at the annual meeting of the American Heart Association held in Orlando, Florida in 2009. Unpublished reports should be considered as preliminary, as analyses may change in the final publication. Patients with heart failure randomized to high-dose losartan treatment (150 mg) in the HEAAL study had a reduced risk of death or heart failure hospitalization compared with patients in the low-dose (50 mg) group. In FAIR-HF, patients with heart failure and concomitant iron deficiency but without severe anaemia who received iron supplementation therapy demonstrated an improvement in symptoms at 24 weeks compared with placebo. The J-CHF study was too sma... European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3182936 Mon, 18 Jan 2010 18:16:39 +0100 3182936 Clinical trials update from the Heart Failure Society of America Meeting 2009: FAST, IMPROVE-HF, COACH galectin-3 substudy, HF-ACTION nuclear substudy, DAD-HF, and MARVEL-1 http://www.medworm.com/index.php?rid=3182935&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F2%2F193%3Frss%3D1 This article presents findings and a commentary on late-breaking trials presented during the meeting of the Heart Failure Society of America in September 2009. Unpublished reports should be considered as preliminary, since analyses may change in the final publication. The FAST trial showed somewhat better performance of intrathoracic impedance for prediction of deterioration in patients with heart failure (HF) when compared with daily weighing. The IMPROVE-HF study reported the benefits of education on the management of patients with systolic HF. Galectin-3 appeared a useful method for improving risk stratification of patients with chronic HF in a substudy of the COACH trial. A nuclear substudy of the HF-ACTION trial failed to demonstrate that resting myocardial perfusion imaging, a measur... European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3182935 Mon, 18 Jan 2010 18:16:39 +0100 3182935 Rationale and design of the multicentre randomized trial investigating the efficacy and safety of pulsed infusions of levosimendan in outpatients with advanced heart failure (LevoRep study) http://www.medworm.com/index.php?rid=3182934&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F2%2F186%3Frss%3D1 Conclusion LevoRep is the first prospective randomized trial to assess the effects of pulsed infusions of an inotrope on hard endpoints as well as on the safety in patients with advanced CHF on an outpatient basis. The results are expected to promote the development of evidence-based recommendations for the ambulatory management of patients with end-stage heart failure. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3182934 Mon, 18 Jan 2010 18:16:39 +0100 3182934 Rationale and design of the {beta}-blocker in heart failure with normal left ventricular ejection fraction ({beta}-PRESERVE) study http://www.medworm.com/index.php?rid=3182933&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F2%2F181%3Frss%3D1 Conclusion This study will provide important evidence, for the first time to our knowledge, of the long-term efficacy of β-blocker therapy in the management of HFNEF. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3182933 Mon, 18 Jan 2010 18:16:38 +0100 3182933 Bone marrow cell transplantation improves cardiac, autonomic, and functional indexes in acute anterior myocardial infarction patients (Cardiac Study) http://www.medworm.com/index.php?rid=3182932&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F2%2F172%3Frss%3D1 Conclusion The beneficial effect of autologous BM cells in post-MI patients with depressed LV function may be mediated by restoration of autonomic control, and improved exercise tolerance. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3182932 Mon, 18 Jan 2010 18:16:38 +0100 3182932 A new model of home-based telemonitored cardiac rehabilitation in patients with heart failure: effectiveness, quality of life, and adherence http://www.medworm.com/index.php?rid=3182931&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F2%2F164%3Frss%3D1 Conclusion In patients with HF, HTCR is equally as effective as SCR and provides a similar improvement in quality of life. Adherence to CR seems to be better for HTCR. Home-based telemonitored cardiac rehabilitation may be a useful alternative form of CR in patients with HF. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3182931 Mon, 18 Jan 2010 18:16:38 +0100 3182931 Left bundle branch block and mortality in patients with acute heart failure syndrome: a substudy of the EFICA cohort http://www.medworm.com/index.php?rid=3182930&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F2%2F156%3Frss%3D1 Conclusion Long-term outcome of patients surviving a severe episode of de novo AHF or AHF complicating a mild CHF is worsened by LBBB. These patients may constitute a subgroup at high risk in whom specific therapeutic solutions should be investigated. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3182930 Mon, 18 Jan 2010 18:16:38 +0100 3182930 The relationship between systolic blood pressure on admission and mortality in older patients with heart failure http://www.medworm.com/index.php?rid=3182929&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F2%2F148%3Frss%3D1 Conclusion Higher SBP on admission is associated with significant lower 30-day and 1-year mortality in patients hospitalized for HF. The relationship is strong, graded, independent of other clinical factors and consistent among subgroups. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3182929 Mon, 18 Jan 2010 18:16:38 +0100 3182929 Measurement of breathlessness in clinical trials in patients with chronic heart failure: the need for a standardized approach: a systematic review http://www.medworm.com/index.php?rid=3182928&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F2%2F137%3Frss%3D1 Conclusion Despite breathlessness being an important and limiting problem for patients with CHF, we found no consensus on which tool should be used for breathlessness severity, little methodological research to develop such a tool, and a lack of focus on breathlessness as a symptom. A consistent approach to studying breathlessness in patients with CHF is needed in order to make headway in managing this key patient priority. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3182928 Mon, 18 Jan 2010 18:16:38 +0100 3182928 Red blood cell distribution width and 1-year mortality in acute heart failure http://www.medworm.com/index.php?rid=3182927&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F2%2F129%3Frss%3D1 Conclusion Red blood cell distribution width is frequently elevated among patients with acute HF and does not appear to be associated with nutritional status, transfusion history, or inflammation. Red blood cell distribution width independently predicts 1-year mortality in acute HF. The value of RDW appears additive to other established prognostic variables such as NT-proBNP. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3182927 Mon, 18 Jan 2010 18:16:38 +0100 3182927 The impact of impaired renal function on mortality in patients with acutely decompensated chronic heart failure http://www.medworm.com/index.php?rid=3182926&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F2%2F122%3Frss%3D1 Conclusion Admission creatinine level strongly predicts medium- and long-term mortality after hospitalization in patients with ADHF, and serves as a cheap and fast clinical marker to identify patients at risk of death. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3182926 Mon, 18 Jan 2010 18:16:38 +0100 3182926 Prevalence and natural history of heart disease in adults with primary mitochondrial respiratory chain disease http://www.medworm.com/index.php?rid=3182925&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F2%2F114%3Frss%3D1 Conclusion All patients with RCD should undergo careful and repeated clinical assessment to diagnose and manage cardiovascular involvement. However, life-threatening cardiovascular complications rarely occur, and the prognosis is generally favourable. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3182925 Mon, 18 Jan 2010 18:16:38 +0100 3182925 Functional effects of glucose transporters in human ventricular myocardium http://www.medworm.com/index.php?rid=3182924&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F2%2F106%3Frss%3D1 Conclusions Positive inotropic effect of insulin is pronounced in ICM, but underlying mechanisms are unaltered. The Ca2+-independent PIE of insulin is mediated via glucose-transporters. Together with the Ca2+-dependent PI-3-kinase mediated pathway, it is responsible for the entire PIE. Substrate-dependency affirms a glucose-dependent part of the PIE. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3182924 Mon, 18 Jan 2010 18:16:38 +0100 3182924 Erythropoietin, iron, or both in heart failure: FAIR-HF in perspective http://www.medworm.com/index.php?rid=3182923&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F2%2F104%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3182923 Mon, 18 Jan 2010 18:16:38 +0100 3182923 HEAAL: the final chapter in the story of angiotensin receptor blockers in heart failure--lessons learnt from a decade of trials http://www.medworm.com/index.php?rid=3182922&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F2%2F99%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3182922 Mon, 18 Jan 2010 18:16:37 +0100 3182922 What are the true prognostic differences between heart failure with preserved and reduced ejection fraction? http://www.medworm.com/index.php?rid=3102788&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F1%2F98%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3102788 Fri, 18 Dec 2009 15:55:17 +0100 3102788 Possible acute and chronic synergistic effect of dual chamber pacing and disopyramide in obstructive hypertrophic cardiomyopathy: a case report http://www.medworm.com/index.php?rid=3102787&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F1%2F94%3Frss%3D1 It remains unclear whether the combination of dual-chamber (DDD) pacing and disopyramide can achieve prolonged left ventricular outflow tract (LVOT) gradient reduction and symptom relief in patients with obstructive hypertrophic cardiomyopathy (HCM). In an HCM patient with a severe LVOT gradient, the combination of DDD pacing and disopyramide achieved marked improvement of gradient in the catheter laboratory and also after medium-term follow-up. The patient's severe dyspnoea was alleviated during the follow-up period. This combination might enable physicians to treat and manage elderly symptomatic obstructive HCM patients with a severe LVOT gradient more effectively and less invasively. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3102787 Fri, 18 Dec 2009 15:55:17 +0100 3102787 Caveat medicus! Pulmonary hypertension in the elderly: a word of caution http://www.medworm.com/index.php?rid=3102786&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F1%2F89%3Frss%3D1 Heart failure with preserved ejection fraction (HFpEF) is a common but under-recognized cause of pulmonary hypertension (PH), particularly among the elderly. While elevated pulmonary artery pressures are clearly associated with increased mortality in HFpEF, it remains unknown whether or how pulmonary vascular disease in HFpEF should be treated. This case emphasizes the importance of maintaining a high index of suspicion for HFpEF in elderly patients presenting with PH and illustrates potential hazards associated with selective pulmonary vasodilation in this growing population. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3102786 Fri, 18 Dec 2009 15:55:17 +0100 3102786 Bridging the gap in heart failure prevention: rationale and design of the Nurse-led Intervention for Less Chronic Heart Failure (NIL-CHF) Study http://www.medworm.com/index.php?rid=3102785&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F1%2F82%3Frss%3D1 Conclusion As one of the largest randomized studies of its kind, NIL-CHF will ultimately provide important insights into the potential to prevent CHF via prolonged and intensive disease management. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3102785 Fri, 18 Dec 2009 15:55:16 +0100 3102785 Rationale and design of a randomized, double-blind, placebo-controlled outcome trial of ivabradine in chronic heart failure: the Systolic Heart Failure Treatment with the If Inhibitor Ivabradine Trial (SHIFT) http://www.medworm.com/index.php?rid=3102784&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F1%2F75%3Frss%3D1 Conclusion The SHIFT study will assess if a heart rate reduction by direct sinus node inhibition can reduce cardiovascular outcomes in patients with chronic heart failure and left-ventricular systolic dysfunction. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3102784 Fri, 18 Dec 2009 15:55:16 +0100 3102784 An economic evaluation of rosuvastatin treatment in systolic heart failure: evidence from the CORONA trial http://www.medworm.com/index.php?rid=3102783&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F1%2F66%3Frss%3D1 Conclusion This economic analysis showed that a significant reduction in major CV events with rosuvastatin led to significantly reduced costs of CV hospitalizations and procedures. The reduction in associated costs for major CV events was found to offset partially (by 44%) the cost of rosuvastatin treatment in patients with systolic heart failure. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3102783 Fri, 18 Dec 2009 15:55:16 +0100 3102783 Impact of gender on benefits of exercise training on sympathetic nerve activity and muscle blood flow in heart failure http://www.medworm.com/index.php?rid=3102782&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F1%2F58%3Frss%3D1 Conclusion The benefits of exercise training on neurovascular control and functional capacity in patients with HF are independent of gender. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3102782 Fri, 18 Dec 2009 15:55:16 +0100 3102782 Integrating functional and anatomical information to guide cardiac resynchronization therapy http://www.medworm.com/index.php?rid=3102781&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F1%2F52%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3102781 Fri, 18 Dec 2009 15:55:16 +0100 3102781 Diagnostic performance of multisequential cardiac magnetic resonance imaging in acute cardiac allograft rejection http://www.medworm.com/index.php?rid=3102780&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F1%2F45%3Frss%3D1 Conclusion Cardiac magnetic resonance imaging is a promising modality for non-invasive detection of cardiac allograft rejection. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3102780 Fri, 18 Dec 2009 15:55:16 +0100 3102780 Differential prognostic effect of systolic blood pressure on mortality according to left-ventricular function in patients with acute heart failure http://www.medworm.com/index.php?rid=3102779&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F1%2F38%3Frss%3D1 Conclusion In patients with AHF, SBP showed a differential prognostic effect on mortality according to LVEF status; when LVEF was ≤40%, SBP was linearly and inversely associated with mortality. Conversely, in patients with LVEF ≥50% this relationship showed a J-shape pattern. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3102779 Fri, 18 Dec 2009 15:55:16 +0100 3102779 Acute kidney injury and outcomes in acute decompensated heart failure: evaluation of the RIFLE criteria in an acutely ill heart failure population http://www.medworm.com/index.php?rid=3102778&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F1%2F32%3Frss%3D1 Conclusion Acute kidney injury evaluated by the RIFLE criteria was associated with a poorer outcome for patients with ADHF. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3102778 Fri, 18 Dec 2009 15:55:16 +0100 3102778 Heart failure registry: a valuable tool for improving the management of patients with heart failure http://www.medworm.com/index.php?rid=3102777&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F1%2F25%3Frss%3D1 Conclusion The S-HFR is a valuable tool for improving the management of patients with HF, since it enables participating centres to focus on their own potential for improving diagnoses and medical treatment, through the online reports provided. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3102777 Fri, 18 Dec 2009 15:55:16 +0100 3102777 Primary care burden and treatment of patients with heart failure and chronic obstructive pulmonary disease in Scotland http://www.medworm.com/index.php?rid=3102776&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F1%2F17%3Frss%3D1 Conclusion Chronic obstructive pulmonary disease is a frequent comorbidity in patients with HF and represents a significant healthcare burden to primary care. Although beta-blocker prescribing in the community has increased, less than a fifth of patients with HF and COPD received beta-blockers. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3102776 Fri, 18 Dec 2009 15:55:16 +0100 3102776 L41Q polymorphism of the G protein coupled receptor kinase 5 is associated with left ventricular apical ballooning syndrome http://www.medworm.com/index.php?rid=3102775&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F1%2F13%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3102775 Fri, 18 Dec 2009 15:55:16 +0100 3102775 MEF2 transcriptional activity maintains mitochondrial adaptation in cardiac pressure overload http://www.medworm.com/index.php?rid=3102774&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F1%2F4%3Frss%3D1 Conclusion Our data suggest that MEF2 transcriptional activity is required for mitochondrial function and its inhibition predisposes the heart to impaired mitochondrial function, overproduction of ROS, enhanced cell death, and cardiac dysfunction, following pressure overload. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3102774 Fri, 18 Dec 2009 15:55:16 +0100 3102774 Thoughts from an outgoing Editor-in-Chief http://www.medworm.com/index.php?rid=3102773&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F1%2F3%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3102773 Fri, 18 Dec 2009 15:55:16 +0100 3102773 Letter from the incoming Editor-in-Chief of the European Journal of Heart Failure http://www.medworm.com/index.php?rid=3102772&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F12%2F1%2F1%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3102772 Fri, 18 Dec 2009 15:55:16 +0100 3102772 The prognostic role of echocardiographic indices in chronic heart failure: right ventricle revisited http://www.medworm.com/index.php?rid=3009728&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F12%2F1220%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3009728 Thu, 19 Nov 2009 16:06:20 +0100 3009728 Clinical trials update from the European Society of Cardiology Meeting 2009: AAA, RELY, PROTECT, ACTIVE-I, European CRT survey, German pre-SCD II registry, and MADIT-CRT http://www.medworm.com/index.php?rid=3009727&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F12%2F1214%3Frss%3D1 This article provides information and a commentary on trials relevant to the pathophysiology, prevention, and treatment of heart failure presented at the annual meeting of the European Society of Cardiology held in Barcelona in 2009. The AAA study does not support the routine use of aspirin for the prevention of vascular events in patients with asymptomatic atherosclerosis. RELY suggests that dabigatran may be more effective than warfarin for the prevention of stroke in patients with atrial fibrillation. Rolofylline was not superior to placebo in improving outcomes in patients with acute heart failure enrolled in the PROTECT study, but dyspnoea was improved. Data from ACTIVE-I suggest that irbesartan does not provide additional therapeutic benefit in patients with atrial fibrillation who a... European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3009727 Thu, 19 Nov 2009 16:06:20 +0100 3009727 'Hospital at home' care model as an effective alternative in the management of decompensated chronic heart failure http://www.medworm.com/index.php?rid=3009726&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F12%2F1208%3Frss%3D1 Conclusion Hospital at home care allows an important reduction in the costs during the index episode compared with hospital care, whilst maintaining similar outcomes with respect to cardiovascular mortality and morbidity and quality of life at 1 year follow-up. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3009726 Thu, 19 Nov 2009 16:06:20 +0100 3009726 Depressive symptoms and outcomes in patients with heart failure: data from the COACH study http://www.medworm.com/index.php?rid=3009725&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F12%2F1202%3Frss%3D1 Conclusion In patients with HF, depression is independently associated with poor outcomes. These findings highlight the need for continued exploration of whether improvements in depression lead to better cardiovascular outcomes. The study was registered at clinical trial (www.trialregister.nl): NCT 98675639. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3009725 Thu, 19 Nov 2009 16:06:20 +0100 3009725 Effect of simvastatin vs. rosuvastatin on adiponectin and haemoglobin A1c levels in patients with non-ischaemic chronic heart failure http://www.medworm.com/index.php?rid=3009724&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F12%2F1195%3Frss%3D1 Conclusion These findings suggest that hydrophilic rosuvastatin but not lipophilic simvastatin increases adiponectin and decreases HbA1c levels in patients with NICHF. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3009724 Thu, 19 Nov 2009 16:06:20 +0100 3009724 The obesity paradox in stable chronic heart failure does not persist after matching for indicators of disease severity and confounders http://www.medworm.com/index.php?rid=3009723&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F12%2F1189%3Frss%3D1 Conclusion The obesity paradox does not appear to persist in a matched setting with respect to indicators of disease severity and other confounders. NT-proBNP remains an independent prognostic indicator of adverse outcome irrespective of obesity status. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3009723 Thu, 19 Nov 2009 16:06:20 +0100 3009723 The impact of concurrent heart failure on prognosis in patients with chronic obstructive pulmonary disease http://www.medworm.com/index.php?rid=3009722&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F12%2F1182%3Frss%3D1 Conclusion Heart failure is a strong independent predictor of all-cause mortality in patients with a diagnosis of COPD. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3009722 Thu, 19 Nov 2009 16:06:20 +0100 3009722 Cardiac mortality in {beta}-thalassemia major: resting but not dobutamine stress echocardiography predicts mortality among initially cardiac disease-free patients in a prospective 12-year study http://www.medworm.com/index.php?rid=3009721&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F12%2F1178%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3009721 Thu, 19 Nov 2009 16:06:20 +0100 3009721 Right atrial size and deformation in patients with dilated cardiomyopathy undergoing cardiac resynchronization therapy http://www.medworm.com/index.php?rid=3009720&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F12%2F1169%3Frss%3D1 Conclusion Right atrial area index was increased and RA myocardial deformation was impaired in patients with DCM who were non-responders to CRT. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3009720 Thu, 19 Nov 2009 16:06:20 +0100 3009720 Increased plasma retinol binding protein 4 levels in patients with inflammatory cardiomyopathy http://www.medworm.com/index.php?rid=3009719&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F12%2F1163%3Frss%3D1 Conclusion Elevated RBP 4 plasma concentrations, induced by IL-8, might be one mechanism leading to a higher incidence of diabetes in patients with DCMi. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3009719 Thu, 19 Nov 2009 16:06:20 +0100 3009719 Red cell distribution width: an inexpensive and powerful prognostic marker in heart failure http://www.medworm.com/index.php?rid=3009718&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F12%2F1155%3Frss%3D1 Conclusion Red cell distribution width is a readily available test in the HF-population with similar independent prognostic power to NT-proBNP across the first to third quartiles. Prognostic models in HF should include RDW and further investigation is necessary to determine the pathological mechanism of the relationship. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3009718 Thu, 19 Nov 2009 16:06:20 +0100 3009718 Red cell distribution width has incremental prognostic value to B-type natriuretic peptide in acute heart failure http://www.medworm.com/index.php?rid=3009717&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F12%2F1152%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3009717 Thu, 19 Nov 2009 16:06:20 +0100 3009717 Implementation of device therapy (cardiac resynchronization therapy and implantable cardioverter defibrillator) for patients with heart failure in Europe: changes from 2004 to 2008 http://www.medworm.com/index.php?rid=3009716&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F12%2F1143%3Frss%3D1 Conclusion Implantation rates of devices for HF, in particular ICD and CRT-D, have increased significantly between 2004 and 2008 in Europe, but there remain major differences between countries. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3009716 Thu, 19 Nov 2009 16:06:20 +0100 3009716 Heart failure in patients hospitalized with acute coronary syndromes: observations from the Gulf Registry of Acute Coronary Events (Gulf RACE) http://www.medworm.com/index.php?rid=3009715&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F12%2F1135%3Frss%3D1 Conclusion Heart failure complicates a substantial proportion of ACS admissions in the Arab Middle East and is associated with higher in-hospital death. Younger patients with ACS have a higher relative increase in mortality related to HF. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3009715 Thu, 19 Nov 2009 16:06:19 +0100 3009715 Normal systolic blood pressure and risk of heart failure in US male physicians http://www.medworm.com/index.php?rid=3009714&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F12%2F1129%3Frss%3D1 Conclusion Our findings suggest a linear relationship between normotensive SBP and HF risk. Strategies to prevent HF, such as lifestyle modification, should be emphasized across all blood pressure ranges. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3009714 Thu, 19 Nov 2009 16:06:19 +0100 3009714 Impaired cellular contractile function in thiamine-deficient rat cardiomyocytes http://www.medworm.com/index.php?rid=3009713&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F12%2F1126%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3009713 Thu, 19 Nov 2009 16:06:19 +0100 3009713 Food-restriction in obese dyslipidaemic diabetic mice partially restores basal contractility but not contractile reserve http://www.medworm.com/index.php?rid=3009712&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F12%2F1118%3Frss%3D1 Conclusion Food-restriction in obese diabetic mice leads to improved cardiac performance by diminishing cardiac load and by ameliorating the intrinsic contractile properties of the cardiac muscle. However, cardiac reserve under dobutamine stimulation did not increase. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3009712 Thu, 19 Nov 2009 16:06:19 +0100 3009712 Acute coronary syndromes, heart failure, and diabetes in the Gulf Registry of Acute Coronary Events http://www.medworm.com/index.php?rid=3009711&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F12%2F1116%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3009711 Thu, 19 Nov 2009 16:06:19 +0100 3009711 The Nobel Prize for medicine for telomere biology and relevance to heart failure research http://www.medworm.com/index.php?rid=3009710&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F12%2F1113%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=3009710 Thu, 19 Nov 2009 16:06:19 +0100 3009710 What is the relationship between cardiac and peripheral ghrelin production? Reply http://www.medworm.com/index.php?rid=2940914&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F11%2F1111-a%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2940914 Thu, 29 Oct 2009 23:07:38 +0100 2940914 Ghrelin resistance in heart failure or why failing cardiomyocytes do not produce ghrelin: the same problem? http://www.medworm.com/index.php?rid=2940913&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F11%2F1111%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2940913 Thu, 29 Oct 2009 23:07:37 +0100 2940913 Chronic Heart Failure (Oxford Cardiology Library) http://www.medworm.com/index.php?rid=2940912&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F11%2F1110%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2940912 Thu, 29 Oct 2009 23:07:37 +0100 2940912 Severe cardiomyopathy following treatment with the tumour necrosis factor-{alpha} inhibitor adalimumab for Crohn's disease http://www.medworm.com/index.php?rid=2940911&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F11%2F1106%3Frss%3D1 Adalimumab belongs to the group of tumour necrosis factor- inhibitors and has been approved for the treatment Crohn's Disease since 2007. Herein we report a severe adverse reaction to adalimumab in a 25-year-old female patient. One week after the initial-dose of adalimumab (160 mg), which was initiated due to an acute exacerbation of Crohn's disease, the patient developed a fulminant cardiomyopathy. In severe cardiogenic shock, the patient required an extracorporeal membrane-oxygenation system for 8 days until cardiac recovery. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2940911 Thu, 29 Oct 2009 23:07:37 +0100 2940911 Timing of eplerenone initiation and outcomes in patients with heart failure after acute myocardial infarction complicated by left ventricular systolic dysfunction: insights from the EPHESUS trial http://www.medworm.com/index.php?rid=2940910&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F11%2F1099%3Frss%3D1 Conclusion An earlier eplerenone administration (3–7days) post-AMI improved outcomes in patients with LVSD and HF. This benefit was not observed when eplerenone was initiated later (≥7days). (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2940910 Thu, 29 Oct 2009 23:07:37 +0100 2940910 Adherence to medication according to sex and age in the CHARM programme http://www.medworm.com/index.php?rid=2940909&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F11%2F1092%3Frss%3D1 Conclusion Women, particularly those <75 years of age, were less likely to be adherent in this large sample of patients with symptomatic heart failure. Understanding factors associated with adherence may provide opportunities for intervention. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2940909 Thu, 29 Oct 2009 23:07:37 +0100 2940909 Rationale and design of Ferinject(R) Assessment in patients with IRon deficiency and chronic Heart Failure (FAIR-HF) study: a randomized, placebo-controlled study of intravenous iron supplementation in patients with and without anaemia http://www.medworm.com/index.php?rid=2940908&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F11%2F1084%3Frss%3D1 Conclusion This study will provide evidence on the efficacy and safety of iron repletion with ferric carboxymaltose in CHF patients with ID with and without anaemia. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2940908 Thu, 29 Oct 2009 23:07:37 +0100 2940908 Is taking part in clinical trials good for your health? A cohort study http://www.medworm.com/index.php?rid=2940907&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F11%2F1078%3Frss%3D1 Conclusion Those patients with chronic heart failure who express a willingness to take part in a clinical trial, appear to have a better prognosis than those who do not. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2940907 Thu, 29 Oct 2009 23:07:37 +0100 2940907 The safety and tolerability of darbepoetin alfa in patients with anaemia and symptomatic heart failure http://www.medworm.com/index.php?rid=2940906&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F11%2F1071%3Frss%3D1 Conclusion Darbepoetin alfa was well tolerated with an AE profile similar to placebo in HF subjects treated to a target Hb of 14.0 ± 1.0 g/dL. Contrary to recent data in other patient populations, there was no evidence of increased risk of mortality or cardiovascular events. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2940906 Thu, 29 Oct 2009 23:07:37 +0100 2940906 Sleep apnoea induces cardiac electrical instability assessed by T-wave alternans in patients with congestive heart failure http://www.medworm.com/index.php?rid=2940905&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F11%2F1063%3Frss%3D1 Conclusion In CHF patients, sleep apnoea induces cardiac electrical instability manifested as TWA, reflecting increased risk of nocturnal SCD. Moreover, some CHF patients with sleep apnoea exhibit nighttime predominant TWA. Therefore, TWA should also be evaluated during the night. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2940905 Thu, 29 Oct 2009 23:07:37 +0100 2940905 Serum levels of large tenascin-C variants, matrix metalloproteinase-9, and tissue inhibitors of matrix metalloproteinases in concentric versus eccentric left ventricular hypertrophy http://www.medworm.com/index.php?rid=2940904&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F11%2F1057%3Frss%3D1 Conclusion Our data suggest that myocardial remodelling in LVH is associated with changes in serum levels of MMP-9, TIMP-1, -2, -4, and Tn-C splice variants. In addition, B domain containing Tn-C discriminated EH from CH and might be suggested as a potential diagnostic marker. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2940904 Thu, 29 Oct 2009 23:07:37 +0100 2940904 Decreased soluble TWEAK levels predict an adverse prognosis in patients with chronic stable heart failure http://www.medworm.com/index.php?rid=2940903&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F11%2F1050%3Frss%3D1 Conclusion In contrast to other cytokines shown to be increased in heart failure patients, plasma levels of sTWEAK are significantly reduced in chronic stable heart failure. In addition, lower plasma levels of sTWEAK predict an adverse prognosis independent of established risk markers such as NT-proBNP. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2940903 Thu, 29 Oct 2009 23:07:37 +0100 2940903 Adjusting for clinical covariates improves the ability of B-type natriuretic peptide to distinguish cardiac from non-cardiac dyspnoea: a sub-study of HEARD-IT http://www.medworm.com/index.php?rid=2940902&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F11%2F1043%3Frss%3D1 Conclusion Adjusting BNP for important covariates may improve its ability to distinguish cardiac from non-cardiac dyspnoea. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2940902 Thu, 29 Oct 2009 23:07:37 +0100 2940902 Lipoprotein components and risk of congestive heart failure in 84 740 men and women in the Apolipoprotein MOrtality RISk study (AMORIS) http://www.medworm.com/index.php?rid=2940901&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F11%2F1036%3Frss%3D1 Conclusion Over and above adjustment factors, the apoB/apoA-1 ratio and TG were the most predictive of the LC, but all LC were highly significantly related to the development of HF. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2940901 Thu, 29 Oct 2009 23:07:37 +0100 2940901 The role of Lamin A/C mutations in Danish patients with idiopathic dilated cardiomyopathy http://www.medworm.com/index.php?rid=2940900&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F11%2F1031%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2940900 Thu, 29 Oct 2009 23:07:37 +0100 2940900 Transplantation with survivin-engineered mesenchymal stem cells results in better prognosis in a rat model of myocardial infarction http://www.medworm.com/index.php?rid=2940899&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F11%2F1023%3Frss%3D1 Conclusion Transplantation with SVV-engineered MSCs by lentiviral vector leads to better prognosis for MI by enhancing cellular survival. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2940899 Thu, 29 Oct 2009 23:07:36 +0100 2940899 Clinical trial participation: are we studying the patients we are trying to treat? http://www.medworm.com/index.php?rid=2940898&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F11%2F1021%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2940898 Thu, 29 Oct 2009 23:07:36 +0100 2940898 Staged heart transplantation and chemotherapy as a treatment option in patients with severe cardiac light-chain amyloidosis http://www.medworm.com/index.php?rid=2844173&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F10%2F1014%3Frss%3D1 Conclusion Heart transplantation in advanced cardiac amyloidosis is a promising approach to interrupting the vicious circle of ineligibility for potential curative chemotherapeutic treatment and extremely poor prognosis of cardiac amyloidosis without chemotherapy. Highly urgent heart transplantation combined with subsequent HDM–ASCT appears to offer a successful treatment option to improve the poor outcome of cardiac amyloidosis. However, it should be restricted to highly selected patients in specialized centres. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2844173 Mon, 28 Sep 2009 23:00:00 +0100 2844173 Elevated serum uric acid levels following heart transplantation predict all-cause and cardiac mortality http://www.medworm.com/index.php?rid=2844172&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F10%2F1005%3Frss%3D1 Conclusion Elevated SUA at 1 year post-HTx, or a modest rather than a marked decline in SUA levels during the first year post-HTx, is associated with an increased risk of mortality. Although the pathophysiological mechanism is unclear, our data indicate a potential relationship between SUA and inflammation which should be explored further. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2844172 Mon, 28 Sep 2009 23:00:00 +0100 2844172 Significance of anaemia in patients with advanced heart failure receiving long-term mechanical circulatory support http://www.medworm.com/index.php?rid=2844171&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F10%2F1000%3Frss%3D1 Conclusion Anaemia is related to adverse outcomes in patients receiving prolonged LVAD support. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2844171 Mon, 28 Sep 2009 23:00:00 +0100 2844171 Hawthorn Extract Randomized Blinded Chronic Heart Failure (HERB CHF) Trial http://www.medworm.com/index.php?rid=2844170&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F10%2F990%3Frss%3D1 Conclusion Hawthorn provides no symptomatic or functional benefit when given with standard medical therapy to patients with heart failure. This trial is registered in ClinicalTrials.gov ID: NCT00343902. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2844170 Mon, 28 Sep 2009 23:00:00 +0100 2844170 A randomized, double-blind, placebo-controlled study to determine the effects of valsartan on exercise time in patients with symptomatic heart failure with preserved ejection fraction http://www.medworm.com/index.php?rid=2844169&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F10%2F980%3Frss%3D1 Conclusion In this population, which predominantly included patients with well-controlled hypertension and symptomatic HFPEF, addition of valsartan did not increase exercise time within 14 weeks. However, valsartan 320 mg reduced blood pressure and improved symptoms of perceived exertion (Borg score) during exercise and was generally well-tolerated. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2844169 Mon, 28 Sep 2009 23:00:00 +0100 2844169 Intracoronary infusion of bone marrow-derived mononuclear cells abrogates adverse left ventricular remodelling post-acute myocardial infarction: insights from the reinfusion of enriched progenitor cells and infarct remodelling in acute myocardial infarction (REPAIR-AMI) trial http://www.medworm.com/index.php?rid=2844168&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F10%2F973%3Frss%3D1 Conclusion Intracoronary administration of BMC eliminates the correlation between depressed LVEF after reperfusion therapy and LV expansion during follow-up and, thereby, abrogates early LV remodelling after AMI. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2844168 Mon, 28 Sep 2009 23:00:00 +0100 2844168 Plasma B-type natriuretic peptide and anti-inflammatory cytokine interleukin-10 levels predict adverse clinical outcome in chronic heart failure patients with depressive symptoms: a 1-year follow-up study http://www.medworm.com/index.php?rid=2844167&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F10%2F967%3Frss%3D1 Conclusion Neurohormonal activation and defective anti-inflammatory properties are independent predictors of long-term outcome in hospitalized CHF patients with depressive symptoms. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2844167 Mon, 28 Sep 2009 23:00:00 +0100 2844167 Brain natriuretic peptide for the prediction of sudden cardiac death and ventricular arrhythmias: a meta-analysis http://www.medworm.com/index.php?rid=2844166&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F10%2F958%3Frss%3D1 Conclusion The measurement of BNP has significant value in predicting SCD and VA. However, the benefit of BNP testing in addition to other risk stratification tests is unclear and BNP needs to be evaluated prospectively in combination with other complementary risk stratification tools. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2844166 Mon, 28 Sep 2009 23:00:00 +0100 2844166 Regional abnormalities of myocardial deformation in patients with hypertrophic cardiomyopathy: correlations with delayed enhancement in cardiac magnetic resonance http://www.medworm.com/index.php?rid=2844165&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F10%2F952%3Frss%3D1 Conclusion Areas of reduced left ventricular contractility in deformation analysis are associated with delayed CMR enhancement in patients with HCM. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2844165 Mon, 28 Sep 2009 23:00:00 +0100 2844165 Left ventricular remodelling and torsional dynamics in dilated cardiomyopathy: reversed apical rotation as a marker of disease severity http://www.medworm.com/index.php?rid=2844164&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F10%2F945%3Frss%3D1 Conclusion Reversed apical rotation and loss of LV torsion in patients with DCM is associated with significant LV remodelling, increased electrical dyssynchrony, reduced systolic function, and increased filling pressures, indicating a more advanced disease stage. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2844164 Mon, 28 Sep 2009 23:00:00 +0100 2844164 Gender differences in survival in patients with severe left ventricular dysfunction despite similar extent of myocardial scar measured on cardiac magnetic resonance http://www.medworm.com/index.php?rid=2844163&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F10%2F937%3Frss%3D1 Conclusion In patients with CAD and severely reduced LVEF, women have worse outcomes than men, irrespective of myocardial scar burden. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2844163 Mon, 28 Sep 2009 23:00:00 +0100 2844163 Independent relationship of left atrial size and mortality in patients with heart failure: an individual patient meta-analysis of longitudinal data (MeRGE Heart Failure) http://www.medworm.com/index.php?rid=2844162&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F10%2F929%3Frss%3D1 Conclusion Left atrial area is a powerful predictor of outcome among HF patients with predominantly impaired systolic function, and is independent of, and provides additional prognostic information beyond LV systolic and diastolic function. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2844162 Mon, 28 Sep 2009 23:00:00 +0100 2844162 Intake of very long chain n-3 fatty acids from fish and the incidence of heart failure: the Rotterdam Study http://www.medworm.com/index.php?rid=2844161&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F10%2F922%3Frss%3D1 Conclusion Our findings do not support a major role for fish intake in the prevention of heart failure. The potentially protective effect of EPA plus DHA in diabetic patients, however, warrants further investigation. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2844161 Mon, 28 Sep 2009 23:00:00 +0100 2844161 The accelerated post-infarction progression of cardiac remodelling is associated with genetic changes in an untreated streptozotocin-induced diabetic rat model http://www.medworm.com/index.php?rid=2844160&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F10%2F911%3Frss%3D1 Conclusion The present data suggest that hyperglycaemia up-regulates remodelling-related genes, which may be responsible for the worse outcomes in diabetics than in non-diabetics after AMI. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2844160 Mon, 28 Sep 2009 23:00:00 +0100 2844160 Haemodynamic and arrhythmic effects of moderately cold (22{degrees}C) water immersion and swimming in patients with stable coronary artery disease and heart failure http://www.medworm.com/index.php?rid=2717486&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F9%2F903%3Frss%3D1 Conclusion Patients with compensated CHF tolerate water immersion and swimming in moderately cold water well. However, the increase in PVCs raises concerns about the potential danger of high-grade ventricular arrhythmias. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2717486 Wed, 19 Aug 2009 23:00:00 +0100 2717486 Predictors of survival after aortic valve replacement in patients with low-flow and high-gradient aortic stenosis http://www.medworm.com/index.php?rid=2717485&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F9%2F897%3Frss%3D1 Conclusion The severity of pre-operative systolic and diastolic LV dysfunction is the major predictor of mortality following AVR for low-flow and high-gradient AS. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2717485 Wed, 19 Aug 2009 23:00:00 +0100 2717485 Route of delivery and baseline left ventricular ejection fraction, key factors of bone-marrow-derived cell therapy for ischaemic heart disease http://www.medworm.com/index.php?rid=2717484&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F9%2F887%3Frss%3D1 Conclusion Clinical evidence suggests that route of delivery and baseline LVEF influence the effect of BMSC therapy in treating AMI and chronic IHD. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2717484 Wed, 19 Aug 2009 23:00:00 +0100 2717484 Multi-centre experience on the use of perhexiline in chronic heart failure and refractory angina: old drug, new hope http://www.medworm.com/index.php?rid=2717483&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F9%2F881%3Frss%3D1 Conclusion Perhexiline therapy provides symptomatic relief in the majority of patients with minimal side effects or toxicity. Careful therapeutic level monitoring for dose titration is important to prevent acute and chronic toxicity. Patients with refractory angina were more likely to be responders. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2717483 Wed, 19 Aug 2009 23:00:00 +0100 2717483 Efficacy and safety of nebivolol in elderly heart failure patients with impaired renal function: insights from the SENIORS trial http://www.medworm.com/index.php?rid=2717482&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F9%2F872%3Frss%3D1 Conclusion Nebivolol is safe and has a similar effect in elderly HF patients with mild or moderate renal impairment. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2717482 Wed, 19 Aug 2009 23:00:00 +0100 2717482 Septal rebound stretch reflects the functional substrate to cardiac resynchronization therapy and predicts volumetric and neurohormonal response http://www.medworm.com/index.php?rid=2717481&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F9%2F863%3Frss%3D1 Conclusion Septal rebound stretch appears to be a sensitive and practical diagnostic criterion to quantify the functional substrate amenable to CRT and to predict response. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2717481 Wed, 19 Aug 2009 23:00:00 +0100 2717481 The prognostic significance of heart failure with preserved left ventricular ejection fraction: a literature-based meta-analysis http://www.medworm.com/index.php?rid=2717480&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F9%2F855%3Frss%3D1 Conclusion This literature-based meta-analysis demonstrates that mortality among patients with HFPEF was half that observed in those with HFREF, in contrast to previous reports suggesting that mortality may be similar between both groups. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2717480 Wed, 19 Aug 2009 23:00:00 +0100 2717480 Both in- and out-hospital worsening of renal function predict outcome in patients with heart failure: results from the Coordinating Study Evaluating Outcome of Advising and Counseling in Heart Failure (COACH) http://www.medworm.com/index.php?rid=2717479&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F9%2F847%3Frss%3D1 Conclusion Both in- and out-hospital worsening of renal function are independently related to poor prognosis in patients with heart failure, suggesting that renal function in heart failure patients should be monitored long after discharge. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2717479 Wed, 19 Aug 2009 23:00:00 +0100 2717479 Red blood cell distribution width predicts long-term outcome regardless of anaemia status in acute heart failure patients http://www.medworm.com/index.php?rid=2717478&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F9%2F840%3Frss%3D1 Conclusion Higher RDW levels at discharge were associated with a worse long-term outcome, regardless of haemoglobin levels and anaemia status. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2717478 Wed, 19 Aug 2009 23:00:00 +0100 2717478 Regional clearance of amino-terminal pro-brain natriuretic peptide from human plasma http://www.medworm.com/index.php?rid=2717477&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F9%2F832%3Frss%3D1 Conclusion Plasma NT-proBNP is cleared by multiple tissues in the human circulation with ~55–65% of total clearance occurring in renal tissue. These data provide the first evidence for extra-glomerular clearance of NT-proBNP and suggest a common multisite clearance mechanism subject to generalized regulation. Renal NT-proBNP extraction was sustained in the face of even moderate levels of kidney dysfunction. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2717477 Wed, 19 Aug 2009 23:00:00 +0100 2717477 Plasma concentrations of tumour necrosis factor-alpha, tumour necrosis factor-related apoptosis-inducing ligand, and FasLigand/CD95L in patients with Chagas cardiomyopathy correlate with left ventricular dysfunction http://www.medworm.com/index.php?rid=2717476&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F9%2F825%3Frss%3D1 Conclusion Plasma levels of TNF superfamily ligands are elevated in patients with functional but not arrhythmogenic disturbances, and these death receptor ligands may be potential markers of ventricular dysfunction in CCC. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2717476 Wed, 19 Aug 2009 23:00:00 +0100 2717476 Comparison of four right ventricular systolic echocardiographic parameters to predict adverse outcomes in chronic heart failure http://www.medworm.com/index.php?rid=2717475&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F9%2F818%3Frss%3D1 Conclusion PSVtdi is a strong independent predictor of outcome in HF at a threshold value of 9.5 cm s–1 and appears to be superior to other RV systolic echocardiographic parameters. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2717475 Wed, 19 Aug 2009 23:00:00 +0100 2717475 Galectin-3: a novel mediator of heart failure development and progression http://www.medworm.com/index.php?rid=2717474&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F9%2F811%3Frss%3D1 Galectins are a family of soluble β-galactoside-binding lectins that play many important regulatory roles in inflammation, immunity, and cancer. Recently, a role for galectin-3 in the pathophysiology of heart failure (HF) has been suggested. Numerous studies have demonstrated the up-regulation of galectin-3 in hypertrophied hearts, its stimulatory effect on macrophage migration, fibroblast proliferation, and the development of fibrosis. The latter observation is particularly relevant as cardiac remodelling is an important determinant of the clinical outcome of HF and is linked to disease progression and poor prognosis. Because galectin-3 expression is maximal at peak fibrosis and virtually absent after recovery, routine measurement in patients with HF may prove valuable to identify th... European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2717474 Wed, 19 Aug 2009 23:00:00 +0100 2717474 Myocarditis mimicking Takotsubo cardiomyopathy or Takotsubo cardiomyopathy with secondary inflammation?: reply http://www.medworm.com/index.php?rid=2635602&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F8%2F810%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2635602 Thu, 23 Jul 2009 23:00:00 +0100 2635602 Myocarditis mimicking Takotsubo cardiomyopathy or Takotsubo cardiomyopathy with secondary inflammation? http://www.medworm.com/index.php?rid=2635601&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F8%2F809%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2635601 Thu, 23 Jul 2009 23:00:00 +0100 2635601 Severe anaemia and subcapital femur fracture in a patient with Left Ventricular Assist Device Heart Mate II: the cardiologist's management of this rare patient http://www.medworm.com/index.php?rid=2635600&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F8%2F806%3Frss%3D1 In this report we describe for the first time a patient with an LVAD Heart Mate II (HM II) implanted 6 months before admission, who initially suffered from severe anaemia and later on underwent a successful bipolar hip replacement owing to subcapital fracture of the right femur. The patient was managed successfully by a team approach, which included a cardiologist, anaesthesiologist, orthopaedic surgeon, and LVAD technician. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2635600 Thu, 23 Jul 2009 23:00:00 +0100 2635600 Clinical trials update from the European Society of Cardiology heart failure meeting 2009: CHANCE, B-Convinced, CHAT, CIBIS-ELD, and Signal-HF http://www.medworm.com/index.php?rid=2635599&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F8%2F802%3Frss%3D1 This paper provides information and a commentary on trials relevant to the pathophysiology, prevention, and treatment of heart failure presented at the annual meeting of the Heart Failure Association of the European Society of Cardiology held in Nice. The CHANCE study showed a substantial reduction in morbidity and mortality in a randomized controlled trial (RCT) of a multidisciplinary management programme for patients with chronic heart failure in Russia. Data from the B-Convinced study, also an RCT, suggest that continuation of beta-blocker (BB) therapy in patients hospitalized with worsening heart failure may be associated with improved outcomes when compared with treatment discontinuation. The CHAT study suggests that telephone support can improve prognosis in heart failure patients li... European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2635599 Thu, 23 Jul 2009 23:00:00 +0100 2635599 Design of the Reduction of Events with Darbepoetin alfa in Heart Failure (RED-HF): a Phase III, anaemia correction, morbidity-mortality trial http://www.medworm.com/index.php?rid=2635598&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F8%2F795%3Frss%3D1 Background Patients with heart failure (HF) and anaemia have greater functional impairment, worse symptoms, increased rates of hospital admission, and a higher risk of death, compared with non-anaemic HF patients. Whether correcting anaemia can improve outcomes is unknown. Objective The Reduction of Events with Darbepoetin alfa in Heart Failure trial (RED-HF; Clinical Trials.gov NCT 003 58215) was designed to evaluate the effect of the long-acting erythropoietin-stimulating agent darbepoetin alfa on mortality and morbidity (and quality of life) in patients with HF and anaemia. Methods Approximately 2600 patients with New York Heart Association class II–IV, an ejection fraction ≤40%, and a haemoglobin (Hb) consistently ≤12.0 g/dL but ≥9.0 g/dL will be enrolled. Patients are... European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2635598 Thu, 23 Jul 2009 23:00:00 +0100 2635598 Ghrelin resistance occurs in severe heart failure and resolves after heart transplantation http://www.medworm.com/index.php?rid=2635597&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F8%2F789%3Frss%3D1 Conclusion Heart failure may be associated with resistance to the appetite-stimulating effects of ghrelin, which may contribute to cachexia. Heart transplantation may be associated with resolution of ghrelin resistance, which may contribute to weight gain. These findings are preliminary and should be confirmed in larger trials. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2635597 Thu, 23 Jul 2009 23:00:00 +0100 2635597 A critical comparison of echocardiographic measurements used for optimizing cardiac resynchronization therapy: stroke distance is best http://www.medworm.com/index.php?rid=2635596&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F8%2F779%3Frss%3D1 Conclusion Left ventricular outflow tract VTI provides us with a single, direct measure of global LV function which is robust, and easily applicable in routine clinical practice, and which is effective at improving response to CRT. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2635596 Thu, 23 Jul 2009 23:00:00 +0100 2635596 Effect of piboserod, a 5-HT4 serotonin receptor antagonist, on left ventricular function in patients with symptomatic heart failure http://www.medworm.com/index.php?rid=2635595&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F8%2F771%3Frss%3D1 Conclusion Although patients with chronic HF had a small but significant improvement in LVEF when treated with piboserod for 24 weeks, the result was not reflected in significant changes in other efficacy parameters, and its clinical relevance remains uncertain. Clinical trials.gov, NCT 00421746 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2635595 Thu, 23 Jul 2009 23:00:00 +0100 2635595 Endothelium-dependent and -independent vasodilation is more attenuated in ischaemic than in non-ischaemic heart failure http://www.medworm.com/index.php?rid=2635594&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F8%2F765%3Frss%3D1 Conclusion Endothelium-dependent and -independent vascular response is more attenuated in ischaemic than in non-ischaemic CHF. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2635594 Thu, 23 Jul 2009 23:00:00 +0100 2635594 Activated cell survival cascade protects cardiomyocytes from cell death in Tako-Tsubo cardiomyopathy http://www.medworm.com/index.php?rid=2635593&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F8%2F758%3Frss%3D1 Conclusion PI3K/AKT signalling is activated in TTC. This activated cell survival cascade might protect cardiomyocytes from cell death and also contribute to rapid regeneration in TTC. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2635593 Thu, 23 Jul 2009 23:00:00 +0100 2635593 Increased late sodium currents are related to transcription of neuronal isoforms in a pressure-overload model http://www.medworm.com/index.php?rid=2635592&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F8%2F749%3Frss%3D1 Conclusion The up-regulated expression of the neuronal NaCh isoforms SCN1a and SCN8a could be one mechanism of INaL production, which may contribute to prolongation of APD in the failing heart. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2635592 Thu, 23 Jul 2009 23:00:00 +0100 2635592 Selective activation of PI3K{alpha}/Akt/GSK-3{beta} signalling and cardiac compensatory hypertrophy during recovery from heart failure http://www.medworm.com/index.php?rid=2635591&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F8%2F739%3Frss%3D1 Conclusion Our results indicate that PI3K isoforms are regulated differently during the course of CHF/CR and that the selective activation of PI3K, through Akt, GSK-3β, and mTOR signalling pathways, may be involved in the development of cardiac compensatory hypertrophy and functional restoration. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2635591 Thu, 23 Jul 2009 23:00:00 +0100 2635591 Cellular basis of uraemic cardiomyopathy: a role for erythropoietin? http://www.medworm.com/index.php?rid=2635590&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F8%2F732%3Frss%3D1 The use of erythropoietin (EPO) has revolutionized the treatment of anaemia associated with many conditions including chronic kidney disease (CKD). However, little is known of the cellular impact of EPO on the uraemic heart. The discovery that the EPO receptor (EPOR) is also expressed on non-haematopoietic cells including cardiomyocytes highlights a role of EPO beyond haematopoiesis. Animal models of heart failure have shown EPO can potentially reverse cardiac remodelling and improve myocardial function. Damage to the kidney, during uraemia, results in a decreased EPO production, which may render the uraemic heart more susceptible to damage and heart failure. Here we review current data on the cellular actions of EPO in models of left ventricular hypertrophy and heart failure and highlight... European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2635590 Thu, 23 Jul 2009 23:00:00 +0100 2635590 Did Jesus die of a 'broken heart'? http://www.medworm.com/index.php?rid=2635589&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F8%2F729%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2635589 Thu, 23 Jul 2009 23:00:00 +0100 2635589 Immunological mechanisms of pentoxifylline in chronic heart failure http://www.medworm.com/index.php?rid=2487273&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F7%2F728%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2487273 Tue, 23 Jun 2009 23:00:00 +0100 2487273 Intractable cardiogenic shock in stress cardiomyopathy with left ventricular outflow tract obstruction: is extra-corporeal life support the best treatment? http://www.medworm.com/index.php?rid=2487272&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F7%2F721%3Frss%3D1 We report the use of extra-corporeal cardiopulmonary support (ECLS), in a case of complicating refractory severe cardiogenic shock, in a patient with Tako-tsubo cardiomyopathy (TC). Tako-tsubo cardiomyopathy syndrome is characterized by left ventricular (LV) wall motion abnormalities, usually without coronary artery disease, mimicking the diagnosis of acute coronary syndrome. This ventricular dysfunction is typically reversible in the acute phase, though it can progress into refractory cardiogenic shock with limited therapeutic options available. Here, we report for the first time in a Tako-tsubo patient with refractory cardiogenic shock, the use of ECLS treatment in order to unload the heart, sustain circulation and end-organ perfusion, and promote potential ventricular recovery. Extra-co... European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2487272 Tue, 23 Jun 2009 23:00:00 +0100 2487272 Adherence to angiotensin-converting-enzyme inhibitors and illness beliefs in older heart failure patients http://www.medworm.com/index.php?rid=2487271&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F7%2F715%3Frss%3D1 Conclusion Adherence to ACEI is sub-optimal. Beliefs about HF appear to be associated with objectively measured adherence to ACEI. Future studies should attempt to identify beliefs that consistently predict adherence and examine whether modifying these beliefs can increase adherence to HF medications. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2487271 Tue, 23 Jun 2009 23:00:00 +0100 2487271 Intra-aortic balloon counterpulsation as a bridge to heart transplantation does not impair long-term survival http://www.medworm.com/index.php?rid=2487270&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F7%2F709%3Frss%3D1 Conclusion Intra-aortic balloon pump treatment stabilizes patients in end-stage heart failure, is safe, well tolerated, and is successful in bridging acutely decompensated patients to transplantation. Complications are few and manageable. Following IABP and HTx, short- and long-term survival, biochemical and invasive and non-invasive haemodynamic outcomes were similar to those in electively transplanted patients. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2487270 Tue, 23 Jun 2009 23:00:00 +0100 2487270 Stroke work or systolic dP/dtmax to evaluate acute response to cardiac resynchronization therapy: are they interchangeable? http://www.medworm.com/index.php?rid=2487269&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F7%2F706%3Frss%3D1 Conclusion Although both parameters display an average increase during pacing, the change relative to baseline values of SW and dP/dtmax is not related. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2487269 Tue, 23 Jun 2009 23:00:00 +0100 2487269 Surface electrocardiogram to predict outcome in candidates for cardiac resynchronization therapy: a sub-analysis of the CARE-HF trial http://www.medworm.com/index.php?rid=2487268&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F7%2F699%3Frss%3D1 Conclusion In CARE-HF, QRS duration at baseline did not predict outcome, but QRS at 3 months was a predictor by single variable analysis. Patients with prolonged PR interval and the 5% of patients with right BBB had a particularly high event rate. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2487268 Tue, 23 Jun 2009 23:00:00 +0100 2487268 Repeated autologous bone marrow mononuclear cell therapy in patients with large myocardial infarction http://www.medworm.com/index.php?rid=2487267&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F7%2F691%3Frss%3D1 Conclusion Data from this preliminary study suggest that repeated BMC administration might be a safe and feasible therapeutic strategy for patients with large AMI. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2487267 Tue, 23 Jun 2009 23:00:00 +0100 2487267 Bisoprolol in patients with heart failure and moderate to severe chronic obstructive pulmonary disease: a randomized controlled trial http://www.medworm.com/index.php?rid=2487266&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F7%2F684%3Frss%3D1 Conclusion Initiation of bisoprolol in patients with HF and concomitant moderate or severe COPD resulted in a reduction in FEV1. However, symptoms and quality of life were not impaired. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2487266 Tue, 23 Jun 2009 23:00:00 +0100 2487266 A meta-analysis of the prognostic significance of atrial fibrillation in chronic heart failure http://www.medworm.com/index.php?rid=2487265&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F7%2F676%3Frss%3D1 Conclusion In conclusion, meta-analysis of 16 studies involving 53 969 patients suggests that the presence of AF is associated with an adverse prognosis in CHF irrespective of LV systolic function. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2487265 Tue, 23 Jun 2009 23:00:00 +0100 2487265 Heart failure in left-sided native valve infective endocarditis: characteristics, prognosis, and results of surgical treatment http://www.medworm.com/index.php?rid=2487264&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F7%2F668%3Frss%3D1 Conclusion Left-sided native valve IE complicated by CHF is more frequent in aortic IE and is associated with severe regurgitation. Congestive heart failure is an independent predictor of in-hospital and 1 year mortality. In CHF patients, early surgery is independently associated with reduced mortality and should be widely considered to improve outcome. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2487264 Tue, 23 Jun 2009 23:00:00 +0100 2487264 Natriuretic peptides and echocardiography in acute dyspnoea: implication of elevated levels with normal systolic function http://www.medworm.com/index.php?rid=2487263&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F7%2F659%3Frss%3D1 Conclusion In an acute dyspnoea population with ‘all-comers’ undergoing echocardiography, NPs correlate strongly with structural abnormalities and identify those with preserved LVEF at highest risk for death. Careful interpretation of elevated NP values is needed in the presence of preserved systolic function. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2487263 Tue, 23 Jun 2009 23:00:00 +0100 2487263 Relationship between renal function and serum cardiac troponin T in patients with chronic heart failure http://www.medworm.com/index.php?rid=2487262&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F7%2F653%3Frss%3D1 Conclusion These findings indicate that decreased clearance via the kidney contributes to the elevated cTnT in CHF patients with CKD. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2487262 Tue, 23 Jun 2009 23:00:00 +0100 2487262 Decreased beta-adrenergic responsiveness following hypertrophy occurs only in cardiomyocytes that also re-express beta-myosin heavy chain http://www.medworm.com/index.php?rid=2487261&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F7%2F648%3Frss%3D1 Conclusion These data show that the reduction of beta-adrenergic response occurs only in subsets, rather than in all myocytes, and is coincident with re-expression of beta-MHC. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2487261 Tue, 23 Jun 2009 23:00:00 +0100 2487261 Blockage of receptor for advanced glycation end products prevents development of cardiac dysfunction in db/db type 2 diabetic mice http://www.medworm.com/index.php?rid=2487260&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F7%2F638%3Frss%3D1 Conclusion Activation of RAGE is a significant pathogenetic mechanism for the development of cardiac dysfunction in type 2 diabetes. The underlying mechanisms involve not only the passive biophysical properties of the myocardium but also myocyte function. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2487260 Tue, 23 Jun 2009 23:00:00 +0100 2487260 The QRS interval in patients treated with resynchronization therapy: which value? http://www.medworm.com/index.php?rid=2487259&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F7%2F635%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2487259 Tue, 23 Jun 2009 23:00:00 +0100 2487259 Heart failure and chronic obstructive pulmonary disease: lung function test interpretation: reply http://www.medworm.com/index.php?rid=2433648&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F6%2F632-a%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2433648 Mon, 25 May 2009 04:00:00 +0100 2433648 Heart failure and chronic obstructive pulmonary disease: lung function test interpretation http://www.medworm.com/index.php?rid=2433647&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F6%2F632%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2433647 Mon, 25 May 2009 04:00:00 +0100 2433647 Influence of gender of physicians and patients on guideline-recommended treatment of chronic heart failure in a cross-sectional study: reply http://www.medworm.com/index.php?rid=2433646&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F6%2F631-a%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2433646 Mon, 25 May 2009 04:00:00 +0100 2433646 Influence of gender of physicians and patients on guideline-recommended treatment of chronic heart failure in a cross-sectional study http://www.medworm.com/index.php?rid=2433645&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F6%2F631%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2433645 Mon, 25 May 2009 04:00:00 +0100 2433645 Clinical trials update from the American College of Cardiology 2009: ADMIRE-HF, PRIMA, STICH, REVERSE, IRIS, partial ventricular support, FIX-HF-5, vagal stimulation, REVIVAL-3, pre-RELAX-AHF, ACTIVE-A, HF-ACTION, JUPITER, AURORA, and OMEGA http://www.medworm.com/index.php?rid=2433644&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F11%2F6%2F622%3Frss%3D1 This article provides information and a commentary on trials relevant to the pathophysiology, prevention and treatment of heart failure presented at the American College of Cardiology meeting in 2009. Unpublished reports should be considered as preliminary, since analyses may change in the final publication. 123I-mIBG myocardial scintigraphy was a good predictor of mortality in patients with heart failure in ADMIRE-HF. In PRIMA, use of individualized target NT-proBNP levels failed to improve outcomes compared with usual care in patients hospitalized with symptomatic heart failure. In the STICH trial, additional ventricular reconstruction surgery failed to improve outcomes in patients with ischaemic heart failure undergoing CABG. Cardiac resynchronization therapy may modify disease progress... European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=2433644 Mon, 25 May 2009 04:00:00 +0100 2433644