MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'European Journal of Heart Failure' source. Wed, 08 Feb 2012 09:32:39 +0100 http://www.medworm.com/index.php?rid=5608554&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F14%2F2%2F219%3Frss%3D1 Conclusions Compared with placebo, 6 months treatment with nebivolol did not improve exercise capacity in patients with HFPEF. Its negative chronotropic effect may have contributed to this result. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5608554 Tue, 17 Jan 2012 05:00:00 +0100 5608554 http://www.medworm.com/index.php?rid=5608553&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F14%2F2%2F211%3Frss%3D1 Conclusions In patients with HF, stroke aetiology is influenced by the presence of AF and the underlying cause of HF. Early and late stroke outcome is associated with HF severity but not with the presence of AF. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5608553 Tue, 17 Jan 2012 05:00:00 +0100 5608553 http://www.medworm.com/index.php?rid=5608552&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F14%2F2%2F202%3Frss%3D1 Conclusion A reversible Se- and Zn-deficient cardiomyopathy may occur in patients with intestinal malabsorption. It is characterized by decline of myocardial antioxidant reserve, oxidative damage of cell membranes, and enhanced cell autophagy. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5608552 Tue, 17 Jan 2012 05:00:00 +0100 5608552 http://www.medworm.com/index.php?rid=5608551&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F14%2F2%2F193%3Frss%3D1 Conclusion The present study clearly shows that long term, severe DM in 45-week-old ZDF rats resulted in relatively mild impairment of diastolic LV function, whereas systolic function was well preserved. These data do not support the notion that diabetes per se is a critical factor in the induction of a clinically relevant degree of cardiac dysfunction. Co-morbidities such as hypertension and coronary artery disease probably have larger impacts on myocardial function in diabetic individuals. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5608551 Tue, 17 Jan 2012 05:00:00 +0100 5608551 http://www.medworm.com/index.php?rid=5608550&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F14%2F2%2F185%3Frss%3D1 Conclusions Compared with non-diabetic patients, diabetic patients are at increased risk of CV events post-MI despite no greater LV enlargement or reduction in systolic function. Diabetic patients demonstrate greater concentric remodelling and evidence of higher LV filling pressure, suggesting diastolic dysfunction as a potential mechanism for the higher risk observed among these patients. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5608550 Tue, 17 Jan 2012 05:00:00 +0100 5608550 http://www.medworm.com/index.php?rid=5608549&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F14%2F2%2F176%3Frss%3D1 Conclusions Patients with HF and LVSD have a poor prognosis. However, the mortality rates of all-cause, all-stage HF as measured in the ECHOES cohort are around half those reported for patients diagnosed for the first time with HF during hospital admission. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5608549 Tue, 17 Jan 2012 05:00:00 +0100 5608549 http://www.medworm.com/index.php?rid=5608548&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F14%2F2%2F168%3Frss%3D1 Conclusion The COACH risk engine accurately predicted survival and various measures of recurrent hospitalization in (acute) HF patients. It may therefore become a valuable tool in improving and personalizing patient care and optimizing the use of scarce healthcare resources. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5608548 Tue, 17 Jan 2012 05:00:00 +0100 5608548 http://www.medworm.com/index.php?rid=5608547&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F14%2F2%2F162%3Frss%3D1 Conclusions Pulmonary hypertension predicted all-cause mortality in a heterogeneous group of patients with heart failure. Each 5 mmHg rise in RVSP was associated with a 6% increased risk of death. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5608547 Tue, 17 Jan 2012 05:00:00 +0100 5608547 http://www.medworm.com/index.php?rid=5608546&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F14%2F2%2F155%3Frss%3D1 Conclusion A special regional deformation pattern (preserved deformation in basal segments of LVNC) seems to be of major diagnostic help for the definite differential diagnosis of LVNC and DCM. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5608546 Tue, 17 Jan 2012 05:00:00 +0100 5608546 http://www.medworm.com/index.php?rid=5608545&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F14%2F2%2F147%3Frss%3D1 Conclusions Elevated serum levels of specific microRNAs: miR-423-5p, miR-320a, miR-22, and miR-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5608545 Tue, 17 Jan 2012 05:00:00 +0100 5608545 http://www.medworm.com/index.php?rid=5608544&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F14%2F2%2F138%3Frss%3D1 Conclusions Socioeconomic deprivation is a powerful independent predictor of HF development and adverse outcomes. However, the precise mechanisms accounting for this risk remain elusive. Heart failure represents the endpoint of numerous different pathophysiological processes and ‘chains of events’, each modifiable throughout the disease trajectories. The interaction between SES and HF is accordingly complex. Disentangling the many and varied life course processes is challenging. A better understanding of these issues may help attenuate the health inequalities so clearly evident among patients with HF. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5608544 Tue, 17 Jan 2012 05:00:00 +0100 5608544 http://www.medworm.com/index.php?rid=5608543&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F14%2F2%2F130%3Frss%3D1 The antibody trastuzumab, targeted to inhibit the signalling of ErbB2, a tyrosine kinase receptor overexpressed in 20–30% of breast cancers, improves the prognosis in women affected by this tumour, but produces cardiotoxicity, since ErbB2 is also involved in myocardial homeostasis. In this review, we discuss the pathophysiology of trastuzumab cardiomyopathy and the complex interplay between ErbB2 inhibition and anthracyclines, and we focus on the actual challenges of detecting, monitoring, and managing trastuzumab cardiotoxicity: the research of new, sensitive markers of early trastuzumab toxicity, before the ejection fraction is reduced, is an active field of research. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5608543 Tue, 17 Jan 2012 05:00:00 +0100 5608543 http://www.medworm.com/index.php?rid=5608542&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F14%2F2%2F120%3Frss%3D1 The incidence and prevalence of heart failure have increased significantly over the past few decades. Available data suggest that patients with heart failure independent of the aetiology have viable but dysfunctional myocardium that is potentially salvageable. Although a great deal of research effort has focused on characterizing the molecular basis of heart failure, cardiac metabolism in this disorder remains an understudied discipline. It is known that many aspects of cardiomyocyte energetics are altered in heart failure. These include a shift from fatty acid to glucose as a preferred substrate and a decline in the levels of ATP. Despite these demonstrated changes, there are currently no approved drugs that target metabolic enzymes or proteins in heart failure. This is partly due to our ... European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5608542 Tue, 17 Jan 2012 05:00:00 +0100 5608542 http://www.medworm.com/index.php?rid=5608541&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F14%2F2%2F118%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5608541 Tue, 17 Jan 2012 05:00:00 +0100 5608541 http://www.medworm.com/index.php?rid=5608540&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F14%2F2%2F115%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5608540 Tue, 17 Jan 2012 05:00:00 +0100 5608540 http://www.medworm.com/index.php?rid=5608539&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F14%2F2%2F113%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5608539 Tue, 17 Jan 2012 05:00:00 +0100 5608539 http://www.medworm.com/index.php?rid=5515280&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F14%2F1%2F106%3Frss%3D1 Conclusions At the end of our study we will establish community prevalence and population characteristics of HFpEF, and also evaluate the diagnostic accuracy of current echocardiography parameters and BNP for the diagnosis of the condition. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5515280 Sun, 18 Dec 2011 05:00:00 +0100 5515280 http://www.medworm.com/index.php?rid=5515279&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F14%2F1%2F91%3Frss%3D1 Conclusions Intracoronary BMSC therapy post-STEMI improves LVEF beyond standard medical treatment, in both the short and longer term. G-CSF treatment shows positive but non-significant trends. Both treatments demonstrate safety comparable with conventional medical treatment. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5515279 Sun, 18 Dec 2011 05:00:00 +0100 5515279 http://www.medworm.com/index.php?rid=5515278&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F14%2F1%2F82%3Frss%3D1 Conclusions PDE5 inhibition in HF patients with EOB offers the dual advantage of improving functional capacity and modulating the EOB pattern. PAP and PVR reduction seem to underlie the correction of the breathing disorder. Whether reversal of this unfavourable prognostic signal can affect survival remains unconfirmed at the moment. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5515278 Sun, 18 Dec 2011 05:00:00 +0100 5515278 http://www.medworm.com/index.php?rid=5515277&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F14%2F1%2F74%3Frss%3D1 Conclusions Increased Gal-3 and PIIINP, and low MMP-1 are associated with adverse long-term cardiovascular outcomes but did not predict response to CRT. CRT did not favourably affect serum concentrations of ECCM markers. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5515277 Sun, 18 Dec 2011 05:00:00 +0100 5515277 http://www.medworm.com/index.php?rid=5515276&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F14%2F1%2F61%3Frss%3D1 Conclusions Outcomes including death and hospitalization in this European CRT survey were consistent with results from clinical trials of CRT. At 1 year follow-up, most patients who received a CRT device considered their symptoms improved compared with their pre-implant assessment. Although prospective, this is an observational study of successful CRT implantations, and outcomes in subgroup analyses must be interpreted with appropriate conservatism. Clinical study no: NCT 01185392 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5515276 Sun, 18 Dec 2011 05:00:00 +0100 5515276 http://www.medworm.com/index.php?rid=5515275&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F14%2F1%2F54%3Frss%3D1 Conclusions Higher RDW is independently related to impaired exercise capacity in CHF patients. Increased VO2peak following exercise training relates to the observed changes in RDW. Whether increased RDW is a marker of impaired exercise tolerance, or plays a pathophysiological role in impaired oxygen transport, deserves further investigation. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5515275 Sun, 18 Dec 2011 05:00:00 +0100 5515275 http://www.medworm.com/index.php?rid=5515274&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F14%2F1%2F45%3Frss%3D1 Conclusions Heart failure patients' requests to forgo resuscitation may signify more than simply ‘what-if’ directives for emergency care. DNR decisions may reflect preferences for intervention to enhance quality rather than prolong survival, which is particularly important as these patients have high early mortality. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5515274 Sun, 18 Dec 2011 05:00:00 +0100 5515274 http://www.medworm.com/index.php?rid=5515273&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F14%2F1%2F39%3Frss%3D1 Conclusions Hypoalbuminaemia is common in HFPEF patients and is associated with increased risk of death. Renal dysfunction may be the main pathophysiological mechanism underlying hypoalbuminaemia in HFPEF patients. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5515273 Sun, 18 Dec 2011 05:00:00 +0100 5515273 http://www.medworm.com/index.php?rid=5515272&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F14%2F1%2F32%3Frss%3D1 Conclusions Our data suggest that in a real-life cohort of HF patients, the addition of ST2 and NTproBNP substantially improves the risk stratification for death beyond that of a model that is based only on established mortality risk factors. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5515272 Sun, 18 Dec 2011 05:00:00 +0100 5515272 http://www.medworm.com/index.php?rid=5515271&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F14%2F1%2F22%3Frss%3D1 Conclusion Age, race, sex, and BMI affect MR-proANP levels to various degrees. However, the diagnostic performance of the recommended cut-off point of 120 pmol/L to rule out acute HF was robust across most subgroups. Although both sex and BMI affected MR-proANP levels, they did not alter its overall diagnostic performance. Lower cut-off points for MR-proANP could be considered in younger patients and in patients with a higher BMI, to optimize diagnostic sensitivity. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5515271 Sun, 18 Dec 2011 05:00:00 +0100 5515271 http://www.medworm.com/index.php?rid=5515270&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F14%2F1%2F14%3Frss%3D1 Conclusion In pacing-induced heart failure, DPP4 inhibition preserves the glomerular filtration rate, modulates stroke volume and heart rate, and potentiates the positive inotropic effect of exogenous BNP at no energy expense. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5515270 Sun, 18 Dec 2011 05:00:00 +0100 5515270 http://www.medworm.com/index.php?rid=5515269&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F14%2F1%2F5%3Frss%3D1 Conclusion Our results show that the expression of Dhrs7c, a novel endo/sarcoplasmic reticulum-localized SDR, is inversely correlated with adrenergic stimulation and heart failure development. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5515269 Sun, 18 Dec 2011 05:00:00 +0100 5515269 http://www.medworm.com/index.php?rid=5515268&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F14%2F1%2F1%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5515268 Sun, 18 Dec 2011 05:00:00 +0100 5515268 http://www.medworm.com/index.php?rid=5421853&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F12%2F1381%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5421853 Fri, 18 Nov 2011 05:00:00 +0100 5421853 http://www.medworm.com/index.php?rid=5421852&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F12%2F1376%3Frss%3D1 This article provides information and a commentary on key trials relevant to the pathophysiology, prevention, and treatment of heart failure presented at the European Society of Cardiology meeting held in Paris, France in August 2011. Unpublished reports should be considered as preliminary, since analyses may change in the final publication. Results from ARISTOTLE suggest that apixaban is more effective than warfarin for the prevention of stroke in patients with atrial fibrillation. Electrical dyssynchrony, measured by the time from onset of electrical activity on the surface ECG to activation of myocardium by intrinsic conduction at the pacing site (QLV), was a strong and independent predictor of improvement in ventricular function after cardiac resynchronization therapy (CRT) in an obser... European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5421852 Fri, 18 Nov 2011 05:00:00 +0100 5421852 http://www.medworm.com/index.php?rid=5421851&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F12%2F1370%3Frss%3D1 Conclusion This study will enrol a representative group of hospitalized heart failure patients and measure a range of patient and health service outcomes to inform the design of post-hospital DMPs for heart failure. Enrolment will be completed in 2013. Trial registration: ACTRN12608000263392 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5421851 Fri, 18 Nov 2011 05:00:00 +0100 5421851 http://www.medworm.com/index.php?rid=5421850&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F12%2F1362%3Frss%3D1 Conclusions Worse cognitive functioning can already be observed in early stages of LV dysfunction and heart failure. BNP is a target for further investigation as a risk factor for cognitive decline in the general population. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5421850 Fri, 18 Nov 2011 05:00:00 +0100 5421850 http://www.medworm.com/index.php?rid=5421849&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F12%2F1355%3Frss%3D1 Conclusion Red cell distribution width was found to be associated with long-term incidence of first hospitalization due to HF among middle-aged subjects. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5421849 Fri, 18 Nov 2011 05:00:00 +0100 5421849 http://www.medworm.com/index.php?rid=5421848&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F12%2F1349%3Frss%3D1 Conclusions Right BBB was a predictor of increased mortality in patients with reduced LV systolic function, whereas LBBB was a marker of increased mortality in patients with preserved LV systolic function. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5421848 Fri, 18 Nov 2011 05:00:00 +0100 5421848 http://www.medworm.com/index.php?rid=5421847&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F12%2F1340%3Frss%3D1 Conclusion Clinical signs of congestion are independent predictors of prognosis in ambulatory patients with suspected CHF. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5421847 Fri, 18 Nov 2011 05:00:00 +0100 5421847 http://www.medworm.com/index.php?rid=5421846&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F12%2F1331%3Frss%3D1 Conclusion MitraClip showed a learning curve regarding mid-term durability and completeness of mitral valve repair, and APS predicted mortality. Recently published studies should be interpreted in consideration of these findings. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5421846 Fri, 18 Nov 2011 05:00:00 +0100 5421846 http://www.medworm.com/index.php?rid=5421845&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F12%2F1323%3Frss%3D1 Conclusion Heart failure patients with severe diastolic dysfunction and absence of myocardial CR during DSE had a poorer clinical and echocardiographic response to CRT. The associated evaluations of diastolic function and CR had an additive value in the identification of responders to CRT. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5421845 Fri, 18 Nov 2011 05:00:00 +0100 5421845 http://www.medworm.com/index.php?rid=5421844&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F12%2F1314%3Frss%3D1 Conclusions Circulating HGF levels correlate with all markers of LV remodelling after MI and are associated with rehospitalization for heart failure. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5421844 Fri, 18 Nov 2011 05:00:00 +0100 5421844 http://www.medworm.com/index.php?rid=5421843&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F12%2F1305%3Frss%3D1 Conclusion Aldosterone and cortisol are associated with medium-term LV remodelling when measured early after AMI. The beneficial effects of MR antagonism may relate to blockade of both aldosterone- and cortisol-induced MR activation. ClinicalTrials.gov: NCT00132093 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5421843 Fri, 18 Nov 2011 05:00:00 +0100 5421843 http://www.medworm.com/index.php?rid=5421842&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F12%2F1296%3Frss%3D1 Conclusion Contrary to our hypothesis, cardiac reserve is not significantly impaired in well-compensated outpatients with HFpEF. The abnormal haemodynamic response to exercise (decreased peak VO2, increased Qc/VO2 slope) is similar to that observed in patients with mitochondrial myopathies, suggesting an element of impaired skeletal muscle oxidative metabolism. This impairment may limit functional capacity by two mechanisms: (i) premature skeletal muscle fatigue and (ii) metabolic signals to increase the cardiac output response to exercise which may be poorly tolerated by a left ventricle with impaired diastolic function. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5421842 Fri, 18 Nov 2011 05:00:00 +0100 5421842 http://www.medworm.com/index.php?rid=5421841&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F12%2F1290%3Frss%3D1 Conclusion Systolic PAP and HR are the major determinants of RV MVO2 in IPAH. A further increase of HR and PAP with IPAH progression suggests a compromised RV myocardial oxygen availability. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5421841 Fri, 18 Nov 2011 05:00:00 +0100 5421841 http://www.medworm.com/index.php?rid=5421840&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F12%2F1283%3Frss%3D1 Conclusion Carriers display reduced myocardial work generation in relation to oxygen consumption, in the absence of hypertrophy and flow abnormalities. Hence, impaired myocardial energetics may constitute a primary component of HCM pathogenesis. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5421840 Fri, 18 Nov 2011 05:00:00 +0100 5421840 http://www.medworm.com/index.php?rid=5421839&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F12%2F1275%3Frss%3D1 Conclusions Pressure and volume load induced different functional and molecular adaptations in the RV. These results may have important consequences for therapeutic strategies to prevent RV failure in the growing population of adults with congenital heart disease. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5421839 Fri, 18 Nov 2011 05:00:00 +0100 5421839 http://www.medworm.com/index.php?rid=5421838&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F12%2F1264%3Frss%3D1 Conclusion IGF-1 and VEGF exerted complementary therapeutic effects in post-infarction heart failure. Biodegradable gelatin microspheres provide sustained and controlled growth factor release locally, exposing myocardial tissue without the side effects of systemic administration. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5421838 Fri, 18 Nov 2011 05:00:00 +0100 5421838 http://www.medworm.com/index.php?rid=5421837&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F12%2F1261%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5421837 Fri, 18 Nov 2011 05:00:00 +0100 5421837 http://www.medworm.com/index.php?rid=5421836&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F12%2F1253%3Frss%3D1 This European consensus document aims to identify the main reasons for the apparent lack of progress in the introduction of new medicines for acute heart failure. Relevant issues include not only the heterogeneity of the patient group but also the pharmacology of the medicines themselves and the design of the trials. Above all, this document attempts to provide some pragmatic solutions to this complex syndrome to simplify the execution of meaningful therapeutic endeavours in this area of undoubted unmet clinical need in the future. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5421836 Fri, 18 Nov 2011 05:00:00 +0100 5421836 http://www.medworm.com/index.php?rid=5347198&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F11%2F1244%3Frss%3D1 Conclusions In the initial management of acute HF, HD iv diuretics, per se, do not influence short-term mortality. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5347198 Mon, 24 Oct 2011 04:00:00 +0100 5347198 http://www.medworm.com/index.php?rid=5347197&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F11%2F1238%3Frss%3D1 Conclusion The combined use of sennosides and digoxin was found to be associated with a modest increased risk of digoxin toxicity in HF patients. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5347197 Mon, 24 Oct 2011 04:00:00 +0100 5347197 http://www.medworm.com/index.php?rid=5347196&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F11%2F1231%3Frss%3D1 Conclusions In patients with sarcoidosis and preserved systolic function, myocardial damage is commonly present and may increase the risk of ventricular tachy-arrhythmias. The JMHW Criteria were neither sensitive nor specific for predicting the presence of myocardial LGE. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5347196 Mon, 24 Oct 2011 04:00:00 +0100 5347196 http://www.medworm.com/index.php?rid=5347195&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F11%2F1224%3Frss%3D1 Conclusion The association between RI and poor survival observed in heart failure populations appears to be contingent not simply on the presence of a reduced GFR, but possibly on the mechanism by which GFR is reduced. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5347195 Mon, 24 Oct 2011 04:00:00 +0100 5347195 http://www.medworm.com/index.php?rid=5347194&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F11%2F1216%3Frss%3D1 Conclusion The prevalence of cardiovascular comorbidities is lower in very elderly HF patients and has different prognostic importance. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5347194 Mon, 24 Oct 2011 04:00:00 +0100 5347194 http://www.medworm.com/index.php?rid=5347193&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F11%2F1211%3Frss%3D1 Conclusion The use of PPIs in patients with HF is common. Despite in vitro concerns about negative inotropic effects with PPIs, there is no association with increased risk of mortality in chronic HF patients who use PPIs in an ambulatory setting. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5347193 Mon, 24 Oct 2011 04:00:00 +0100 5347193 http://www.medworm.com/index.php?rid=5347192&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F11%2F1202%3Frss%3D1 Conclusion In patients who underwent SVR, myocardial collagen metabolism was significantly enhanced 6 months after surgery. Serum levels of myocardial collagen turnover biomarkers were related to post-surgical LV systolic and diastolic function. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5347192 Mon, 24 Oct 2011 04:00:00 +0100 5347192 http://www.medworm.com/index.php?rid=5347191&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F11%2F1193%3Frss%3D1 Conclusion Heart transplanted HCM has a heterogeneous genetic background where multiple mutations are uncommon. The clinical course of HCM is not primarily dependent on the presence of multiple sarcomeric mutations. Clinical and genetic evaluation of relatives does not support differential clinical management in HCM based on genetics. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5347191 Mon, 24 Oct 2011 04:00:00 +0100 5347191 http://www.medworm.com/index.php?rid=5347190&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F11%2F1185%3Frss%3D1 Conclusion A large clinical-genetic study has unravelled novel genotype-to-phenotype correlations in HCM and DCM which warrant future investigation of both the underlying mechanisms and the prognostic use. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5347190 Mon, 24 Oct 2011 04:00:00 +0100 5347190 http://www.medworm.com/index.php?rid=5347189&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F11%2F1178%3Frss%3D1 Conclusion Heart failure patients in Saudi Arabia present at a relatively younger age, have a much higher rate of diabetes mellitus, and predominantly have LV systolic dysfunction, which is mainly ischaemic in origin, compared with  patients in developed countries. The preliminary results of the study show potential targets for improvement in care. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5347189 Mon, 24 Oct 2011 04:00:00 +0100 5347189 http://www.medworm.com/index.php?rid=5347188&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F11%2F1172%3Frss%3D1 Conclusions Dietary incompliance, e.g. on the occasion of a ceremonial meal, may lead to marked disturbances in the fluid balance of patients with HF reflected by increased BW and decreased intrathoracic impedance. These findings underline the importance of maintaining stable volume conditions in HF patients. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5347188 Mon, 24 Oct 2011 04:00:00 +0100 5347188 http://www.medworm.com/index.php?rid=5347187&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F11%2F1161%3Frss%3D1 There is growing evidence to support an important role of inflammation in the underlying pathophysiology of heart failure (HF). Indeed, inflammatory cytokine levels are well recognized to be increased in patients with left ventricular dysfunction and appear to have prognostic implications. Monocytes play a pivotal role in the inflammatory cascade and are a major source of both pro- and anti-inflammatory cytokines. They are intimately involved in tissue damage and repair and an imbalance of these processes may have detrimental consequences for the failing myocardium. Importantly, monocytes comprise of distinct subsets with different cell surface markers and functional characteristics and this heterogeneity may be important in understanding their specific role in HF. In HF, monocyte activati... European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5347187 Mon, 24 Oct 2011 04:00:00 +0100 5347187 http://www.medworm.com/index.php?rid=5347186&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F11%2F1159%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5347186 Mon, 24 Oct 2011 04:00:00 +0100 5347186 http://www.medworm.com/index.php?rid=5347185&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F11%2F1157%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5347185 Mon, 24 Oct 2011 04:00:00 +0100 5347185 http://www.medworm.com/index.php?rid=5237030&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F10%2F1154-a%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5237030 Wed, 21 Sep 2011 04:00:00 +0100 5237030 http://www.medworm.com/index.php?rid=5237029&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F10%2F1154%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5237029 Wed, 21 Sep 2011 04:00:00 +0100 5237029 http://www.medworm.com/index.php?rid=5237028&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F10%2F1153%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5237028 Wed, 21 Sep 2011 04:00:00 +0100 5237028 http://www.medworm.com/index.php?rid=5237027&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F10%2F1152-a%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5237027 Wed, 21 Sep 2011 04:00:00 +0100 5237027 http://www.medworm.com/index.php?rid=5237026&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F10%2F1152%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5237026 Wed, 21 Sep 2011 04:00:00 +0100 5237026 http://www.medworm.com/index.php?rid=5237025&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F10%2F1147%3Frss%3D1 This article provides information and a commentary on key trials relevant to the pathophysiology, prevention, and treatment of heart failure (HF) presented at the European Society of Cardiology Heart Failure meeting held in Gothenburg, Sweden in May 2011. Unpublished reports should be considered as preliminary, since analyses may change in the final publication. In the TEHAF study, use of the Health Buddy® monitoring system failed to reduce the number of HF admissions compared with usual care but a subgroup of patients with more recently diagnosed HF may have benefited. In the WHICH study, some reductions in the rate of hospital stay were observed in patients who underwent a nurse-led home-based intervention programme following a hospital admission for an acute HF exacerbation, compare... European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5237025 Wed, 21 Sep 2011 04:00:00 +0100 5237025 http://www.medworm.com/index.php?rid=5237024&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F10%2F1140%3Frss%3D1 Conclusion The acute beneficial impact of ASV is mainly associated with the reduction of afterload resulting in an increase in stroke volume and cardiac output. In contrast, chronic ASV therapy produces LV and LA reverse remodelling resulting in an improvement in LV function and the severity of MR in patients with CHF. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5237024 Wed, 21 Sep 2011 04:00:00 +0100 5237024 http://www.medworm.com/index.php?rid=5237023&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F10%2F1133%3Frss%3D1 Conclusions Novel diastolic strain rate indices are useful for evaluating changes in LV diastolic function after CRT. Improvement in diastolic function was only observed in responders to CRT and patients with non-ischaemic aetiology. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5237023 Wed, 21 Sep 2011 04:00:00 +0100 5237023 http://www.medworm.com/index.php?rid=5237022&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F10%2F1126%3Frss%3D1 Conclusion Left ventricular dP/dtmax measured at baseline and during CRT are predictors of 1-year survival free from all-cause mortality, HTX, or LVAD implantation, but the acute improvement in dP/dtmax is not correlated to clinical outcome. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5237022 Wed, 21 Sep 2011 04:00:00 +0100 5237022 http://www.medworm.com/index.php?rid=5237021&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F10%2F1121%3Frss%3D1 Conclusion Mitral regurgitation has a negative effect on prognosis of patients with HF, but only in patients with severely reduced LVEF. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5237021 Wed, 21 Sep 2011 04:00:00 +0100 5237021 http://www.medworm.com/index.php?rid=5237020&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F10%2F1111%3Frss%3D1 Conclusion Atrial fibrillation is equally common in patients with HF-PEF and HF-REF. In HF-PEF, but not in HF-REF patients, AF was associated with higher NT-proBNP levels and was independently related to death or HF hospitalization. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5237020 Wed, 21 Sep 2011 04:00:00 +0100 5237020 http://www.medworm.com/index.php?rid=5237019&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F10%2F1104%3Frss%3D1 Conclusions Kidney injury molecule-1 and NAG are elevated in symptomatic heart failure. This finding may be present in patients with apparently normal kidney function and indicates tubular injury in chronic heart failure. Kidney injury molecule-1 and NAG are potential markers of CRS with additional prognostic value. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5237019 Wed, 21 Sep 2011 04:00:00 +0100 5237019 http://www.medworm.com/index.php?rid=5237018&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F10%2F1096%3Frss%3D1 Conclusions Morbidity and mortality were not improved by HF treatment guided by BNP levels. However, BNP responders had a significantly better clinical outcome than non-responders. Future research is needed to elucidate the responsible pathophysiological mechanisms in this sub-population. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5237018 Wed, 21 Sep 2011 04:00:00 +0100 5237018 http://www.medworm.com/index.php?rid=5237017&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F10%2F1087%3Frss%3D1 Conclusion These data define varying fibro-inflammatory profiles throughout different stages of HHD. In particular, the observations on MMP9 and TIMP1 raise the possibility of earlier detection of those at risk of evolution to HF which may help focus effective preventative strategies. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5237017 Wed, 21 Sep 2011 04:00:00 +0100 5237017 http://www.medworm.com/index.php?rid=5237016&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F10%2F1078%3Frss%3D1 Conclusions Among community-dwelling older adults without HF, baseline hypoalbuminaemia was associated with increased risk of incident HF during 10 years of follow-up. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5237016 Wed, 21 Sep 2011 04:00:00 +0100 5237016 http://www.medworm.com/index.php?rid=5237015&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F10%2F1070%3Frss%3D1 Conclusion These data suggest cases of RHF and related PAH are relatively common among urban Africans presenting with de novo heart disease. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5237015 Wed, 21 Sep 2011 04:00:00 +0100 5237015 http://www.medworm.com/index.php?rid=5237014&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F10%2F1060%3Frss%3D1 Conclusion Chronic amiodarone results in a rapid phase-III-repolarization and does not increase dispersion of repolarization. These electrophysiological findings are present in healthy hearts and are preserved in heart failure. This contributes to the low proarrhythmic potential of amiodarone in heart failure. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5237014 Wed, 21 Sep 2011 04:00:00 +0100 5237014 http://www.medworm.com/index.php?rid=5237013&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F10%2F1052%3Frss%3D1 Conclusion Our results demonstrate for the first time that cTnI-induced autoimmune response not only leads to increased myocardial inflammation and impaired cardiac function 180 days after chronic coronary artery ligation, but also exacerbates ischaemia/reperfusion injury compared with non-immunized controls. Hence, the presence of cTnI-autoimmunity could render subjects more vulnerable to prospective myocardial injury, be it MI, or secondary revascularization measures. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5237013 Wed, 21 Sep 2011 04:00:00 +0100 5237013 http://www.medworm.com/index.php?rid=5237012&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F10%2F1049%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5237012 Wed, 21 Sep 2011 04:00:00 +0100 5237012 http://www.medworm.com/index.php?rid=5237011&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F10%2F1046%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5237011 Wed, 21 Sep 2011 04:00:00 +0100 5237011 http://www.medworm.com/index.php?rid=5237010&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F10%2F1043%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5237010 Wed, 21 Sep 2011 04:00:00 +0100 5237010 http://www.medworm.com/index.php?rid=5143611&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F9%2F1042%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5143611 Wed, 17 Aug 2011 23:00:00 +0100 5143611 http://www.medworm.com/index.php?rid=5143610&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F9%2F1041%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5143610 Wed, 17 Aug 2011 23:00:00 +0100 5143610 http://www.medworm.com/index.php?rid=5143609&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F9%2F1028%3Frss%3D1 Conclusion Telemonitoring and STS both appear effective interventions to improve outcomes in patients with CHF. Systematic Review Number: Cochrane Database of Systematic Reviews. 2008:Issue 3. Art. No.: CD007228. DOI: 10.1002/14651858.CD007228. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5143609 Wed, 17 Aug 2011 23:00:00 +0100 5143609 http://www.medworm.com/index.php?rid=5143608&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F9%2F1019%3Frss%3D1 Conclusion We developed an automated algorithm for dynamic prediction of cardiovascular events in patients treated with CRT-D devices capable of daily transmission of their diagnostic data via Home Monitoring. This tool may increase patients’ quality of life and reduce morbidity, mortality, and health economic burden, it now warrants prospective studies. ClinicalTrials.gov  NCT00376116. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5143608 Wed, 17 Aug 2011 23:00:00 +0100 5143608 http://www.medworm.com/index.php?rid=5143607&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F9%2F1013%3Frss%3D1 Conclusion Quality of life is similarly impaired in patients with HF-PEF as in HF-REF. These findings further support the need for more pharmacological and non-pharmacological studies in patients with HF-PEF. Trial registration number: NCT 98675639. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5143607 Wed, 17 Aug 2011 23:00:00 +0100 5143607 http://www.medworm.com/index.php?rid=5143606&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F9%2F1006%3Frss%3D1 Conclusion We demonstrated no benefit over placebo for the relief of breathlessness with short-term low-dose oral opioids for CHF patients. Trial registered prior to the recruitment of the first participant with Current Controlled Trials (www.controlled-trials.com; Trial number ISRCTN 85268059). (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5143606 Wed, 17 Aug 2011 23:00:00 +0100 5143606 http://www.medworm.com/index.php?rid=5143605&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F9%2F1000%3Frss%3D1 Conclusion Device-guided RM might have the potential to relieve symptoms of heart failure in outpatients by changing their breathing pattern. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5143605 Wed, 17 Aug 2011 23:00:00 +0100 5143605 http://www.medworm.com/index.php?rid=5143604&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F9%2F992%3Frss%3D1 Conclusion Exercise-derived prognostic indicators demonstrate limited capacity in reflecting cardiac pumping capability in patients treated with LVADs and should therefore be used with caution in interpretation of cardiac organ function. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5143604 Wed, 17 Aug 2011 23:00:00 +0100 5143604 http://www.medworm.com/index.php?rid=5143603&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F9%2F984%3Frss%3D1 Conclusion The present multicentre study suggests that SDI may identify responders to CRT in ischaemic and non-ischaemic patients. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5143603 Wed, 17 Aug 2011 23:00:00 +0100 5143603 http://www.medworm.com/index.php?rid=5143602&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F9%2F974%3Frss%3D1 Conclusions More than one quarter of all CRT procedures are upgrades from existing systems, although this group has not been subject to randomized clinical trials. Our data suggest that there are no significant differences in clinical outcomes or complication rates between upgrades and de novo procedures. Clinical study no NCT 01185392 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5143602 Wed, 17 Aug 2011 23:00:00 +0100 5143602 http://www.medworm.com/index.php?rid=5143601&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F9%2F968%3Frss%3D1 Conclusion The presence of hyponatraemia in outpatients with HF is associated with increased risk of hospitalization or death. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5143601 Wed, 17 Aug 2011 23:00:00 +0100 5143601 http://www.medworm.com/index.php?rid=5143600&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F9%2F961%3Frss%3D1 Conclusions Worsening renal function in hospitalized AHF patients is related to a poor clinical outcome and is predicted by a greater early drop in SBP. Trial registration clinicaltrials.gov identifier NCT00520806. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5143600 Wed, 17 Aug 2011 23:00:00 +0100 5143600 http://www.medworm.com/index.php?rid=5143599&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F9%2F953%3Frss%3D1 Conclusion Mitral annular plane systolic excursion at rest and on exercise correlates well with more sophisticated measurements of ventricular function in HFpEF patients. It is potentially a useful and easily acquired measurement, especially on exercise, for the diagnosis of HFpEF. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5143599 Wed, 17 Aug 2011 23:00:00 +0100 5143599 http://www.medworm.com/index.php?rid=5143598&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F9%2F945%3Frss%3D1 Conclusions Clinical characteristics, inpatient interventions, discharge therapies, and length of stay vary significantly for HF-PEF patients across geographic regions. This has important implications for global clinical trials and outcome studies in HF. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5143598 Wed, 17 Aug 2011 23:00:00 +0100 5143598 http://www.medworm.com/index.php?rid=5143597&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F9%2F937%3Frss%3D1 Conclusions The present study shows that occurrence of LGE in cardiomyopathy is associated with increased LV wall stress and mass. Suspected causes are an increased capillary leakage by stretch, impaired contrast agent redistribution, or increased diffusion distances. It is proposed that LGE should be considered as a potential prognostic determinant of heart failure and severe arrhythmias. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5143597 Wed, 17 Aug 2011 23:00:00 +0100 5143597 http://www.medworm.com/index.php?rid=5143596&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F9%2F929%3Frss%3D1 We will shortly celebrate the 25th anniversary of the publication of the Co-operative North Scandinavian Enalapril Survival Study (CONSENSUS), a clinical trial which revolutionized the treatment of heart failure and highlighted the importance of the renin–angiotensin–aldosterone system (RAAS) in the pathophysiology of heart failure (Figure 1). In this article I will give a brief, historical overview of this exciting quarter-century of discovery related to the RAAS. My focus is on the treatment of heart failure in patients with a low left ventricular ejection fraction. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5143596 Wed, 17 Aug 2011 23:00:00 +0100 5143596 http://www.medworm.com/index.php?rid=5143595&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F9%2F927%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5143595 Wed, 17 Aug 2011 23:00:00 +0100 5143595 http://www.medworm.com/index.php?rid=5143594&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F9%2F925%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5143594 Wed, 17 Aug 2011 23:00:00 +0100 5143594 http://www.medworm.com/index.php?rid=5063545&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F8%2F917%3Frss%3D1 Conclusion This trial is powered to provide a robust evaluation of the effect of pharmacist-led treatment optimization in patients with systolic HF in primary care. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5063545 Mon, 25 Jul 2011 23:00:00 +0100 5063545 http://www.medworm.com/index.php?rid=5063544&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F8%2F909%3Frss%3D1 Aims To describe the rationale and design of the Which Heart failure Intervention is most Cost-effective & consumer friendly in reducing Hospital care (WHICH?) trial. Methods WHICH? is a pragmatic, multicentre, randomized controlled trial that seeks to determine if multidisciplinary management of chronic heart failure (CHF) patients post-acute hospitalization delivered in a patient's own home is superior to care delivered via a specialist CHF outpatient clinic. The composite primary endpoint is all-cause, unplanned recurrent hospitalization or death during 12–18 months of follow-up. Of 688 eligible patients, 280 patients (73% male and 66% principal diagnosis of CHF) with a mean age of 71 ± 14 years have been randomized to home- (n = 143) or clinic-based (n = 137) post-dis... European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5063544 Mon, 25 Jul 2011 23:00:00 +0100 5063544 http://www.medworm.com/index.php?rid=5063543&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F8%2F899%3Frss%3D1 Conclusion In the present proof-of-concept study, the AGE-breaker alagebrium did not improve exercise tolerance in patients with HF and systolic dysfunction, and no changes were observed in a number of secondary endpoints. The present data therefore do not support earlier data which suggested a beneficial effect of alagebrium in systolic HF. Clinical Trial Registration Information: NCT00516646 (http://clinicaltrials.gov) (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5063543 Mon, 25 Jul 2011 23:00:00 +0100 5063543 http://www.medworm.com/index.php?rid=5063542&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F8%2F892%3Frss%3D1 Conclusion This study indicates that azosemide suppresses SNS activation compared with furosemide in patients with CHF, suggesting that long-acting loop diuretics may have more beneficial effects on the prognosis of CHF. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5063542 Mon, 25 Jul 2011 23:00:00 +0100 5063542 http://www.medworm.com/index.php?rid=5063541&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F8%2F885%3Frss%3D1 Conclusion Unlike previous reports, this retrospective evaluation of B2A therapy in HF patients shows no relationship with long-term mortality when adjusted for population differences including BNP.  Large, prospective studies are required to define the risk/benefit ratio of B2As in patients with heart failure. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5063541 Mon, 25 Jul 2011 23:00:00 +0100 5063541 http://www.medworm.com/index.php?rid=5063540&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F8%2F877%3Frss%3D1 Conclusion During the treatment of decompensated heart failure, significant blood pressure reduction is strongly associated with WRF. However, WRF that occurs in the setting of SBP-reduction is not associated with an adverse prognosis, whereas WRF in the absence of this provocation is strongly associated with increased mortality. These data suggest that WRF may represent the final common pathway of several mechanistically distinct processes, each with potentially different prognostic implications. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5063540 Mon, 25 Jul 2011 23:00:00 +0100 5063540 http://www.medworm.com/index.php?rid=5063539&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F8%2F868%3Frss%3D1 Conclusion Uncontrolled VR occurs in one-third of CRT-D patients, who experience AF, and is associated with HF hospitalizations and death and with sub-optimal CRT (lifetime BIVP%<95%). (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5063539 Mon, 25 Jul 2011 23:00:00 +0100 5063539 http://www.medworm.com/index.php?rid=5063538&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F8%2F860%3Frss%3D1 Conclusions Annual BNP increases above 40% predicted all-cause and cardiac death in the subsequent year. Hence, serially measuring BNP levels may present a novel tool for risk stratification and treatment guidance of end-stage renal disease patients on chronic dialysis. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5063538 Mon, 25 Jul 2011 23:00:00 +0100 5063538 http://www.medworm.com/index.php?rid=5063537&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F8%2F852%3Frss%3D1 Conclusion Low homoarginine is a strong risk factor for SCD and death due to heart failure in haemodialysis patients. Further studies are needed to elucidate the underlying mechanisms, offering the potential to develop new interventional strategies. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5063537 Mon, 25 Jul 2011 23:00:00 +0100 5063537 http://www.medworm.com/index.php?rid=5063536&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F8%2F846%3Frss%3D1 Conclusions Plasma NGAL is a measure of kidney injury that at the time of discharge is a strong prognostic indicator of 30 days outcomes in patients admitted for AHF. Clinical trial registration number: NCT 00693745 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5063536 Mon, 25 Jul 2011 23:00:00 +0100 5063536 http://www.medworm.com/index.php?rid=5063535&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F8%2F838%3Frss%3D1 Conclusion Assessment of acute dyspnoea using a VAS is useful in distinguishing HF from NHF, and may be a more valid approach as compared with using descriptors of intensity of breathlessness in the acute setting. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5063535 Mon, 25 Jul 2011 23:00:00 +0100 5063535 http://www.medworm.com/index.php?rid=5063534&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F8%2F830%3Frss%3D1 Conclusion In a Greek population with myocarditis, Chlamydia with viruses was a common finding. Cardiovascular magnetic resonance and PCR proved useful for the detection of myocarditis; EGE and LGE had the best correlation for the development of heart failure. Persistence of the initially detected infective agents was identified in patients who deteriorated further. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5063534 Mon, 25 Jul 2011 23:00:00 +0100 5063534 http://www.medworm.com/index.php?rid=5063533&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F8%2F825%3Frss%3D1 AKT is a serine/threonine protein kinase, also known as protein kinase B, which regulates cardiac growth, myocardial angiogenesis, glucose metabolism, and cell death in cardiac myocytes. AKT is activated by its phosphorylation at Thr 308 and ser 473 by PDK1 and mTORC2, respectively, in response to trophic stimuli such as insulin and insulin growth factor. c-Jun N-Terminal Kinases (JNKs) phosphorylate AKT at Thr 450 and potentiate its interaction with its downstream effectors. The short-term activation of AKT promotes physiological hypertrophy and protection from myocardial injury; whereas, its long-term activation causes pathological hypertrophy and heart failure. In this review we will discuss the role of AKT in regulating signalling pathways in the heart with special emphasis on the role... European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5063533 Mon, 25 Jul 2011 23:00:00 +0100 5063533 http://www.medworm.com/index.php?rid=5063532&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F8%2F823%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5063532 Mon, 25 Jul 2011 23:00:00 +0100 5063532 http://www.medworm.com/index.php?rid=5063531&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F8%2F820%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5063531 Mon, 25 Jul 2011 23:00:00 +0100 5063531 http://www.medworm.com/index.php?rid=5063530&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F8%2F811%3Frss%3D1 Many primary or secondary diseases of the myocardium are accompanied with complex remodelling of the cardiac tissue that results in increased heart mass, often identified as cardiac ‘hypertrophy’. Although there have been numerous attempts at defining such ‘hypertrophy’, the present paper delineates the reasons as to why current definitions of cardiac hypertrophy remain unsatisfying. Based on a brief review of the underlying pathophysiology and tissue and cellular events driving myocardial remodelling with or without changes in heart dimensions, as well as current techniques to detect such changes, we propose to restrict the use of the currently popular term ‘hypertrophy’ to cardiac myocytes that may or may not accompany the more complex tissue rearrange... European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=5063530 Mon, 25 Jul 2011 23:00:00 +0100 5063530 http://www.medworm.com/index.php?rid=4977545&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F7%2F809%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=4977545 Mon, 27 Jun 2011 23:00:00 +0100 4977545 http://www.medworm.com/index.php?rid=4977544&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F7%2F805%3Frss%3D1 This article provides information and a commentary on key trials relevant to the pathophysiology, prevention, and treatment of heart failure (HF) presented at the annual American College of Cardiology meeting held in New Orleans in 2011. Unpublished reports should be considered as preliminary, since analyses may change in the final publication. The STICH trial failed to show a benefit of revascularization on all-cause mortality in patients with HF and coronary artery disease; however, cardiovascular deaths were reduced compared with medical therapy alone. Results from the NorthStar study suggest that patients with clinically stable systolic HF, who are on optimal medical therapy, including those with elevated amino-terminal B-type natriuretic peptide levels, may not benefit from long-term ... European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=4977544 Mon, 27 Jun 2011 23:00:00 +0100 4977544 http://www.medworm.com/index.php?rid=4977543&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F7%2F796%3Frss%3D1 Conclusion The OptiLink HF study is designed to investigate whether early detection of congestion reduces mortality and cardiovascular hospitalization in patients with chronic HF. The study is expected to close recruitment in September 2012 and to report first results in May 2014. ClinicalTrials.gov Identifier: NCT00769457 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=4977543 Mon, 27 Jun 2011 23:00:00 +0100 4977543 http://www.medworm.com/index.php?rid=4977542&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F7%2F785%3Frss%3D1 Conclusion Intra-corporeal VAD support does not have a deleterious impact on post-transplant outcomes. However, post-transplant survival may be poorer in the subgroup of patients supported with extra-corporeal devices. Studies with greater methodological rigour are warranted. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=4977542 Mon, 27 Jun 2011 23:00:00 +0100 4977542 http://www.medworm.com/index.php?rid=4977541&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F7%2F773%3Frss%3D1 Conclusion The present meta-analysis demonstrates that based on data from available observational clinical studies, CABG can be performed with acceptable operative mortality and 5-year actuarial survival in patients with severe LV dysfunction. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=4977541 Mon, 27 Jun 2011 23:00:00 +0100 4977541 http://www.medworm.com/index.php?rid=4977540&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F7%2F765%3Frss%3D1 Conclusion The order of drug administration plays an important role in whether CHF patients reach target doses of bisoprolol and enalapril. For both study drugs, the dose level reached was associated with baseline characteristics and adverse events. In CHF patients not treated with an ACE-I or a beta-blocker, the duration of monotherapy with either type of drug should be shorter than 6 months. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=4977540 Mon, 27 Jun 2011 23:00:00 +0100 4977540 http://www.medworm.com/index.php?rid=4977539&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F7%2F755%3Frss%3D1 Conclusion Aliskiren 150 mg added to standard HF therapy was well tolerated over 12 weeks and provided beneficial changes in neurohumoral biomarkers regardless of concomitant MRA treatment. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=4977539 Mon, 27 Jun 2011 23:00:00 +0100 4977539 http://www.medworm.com/index.php?rid=4977538&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F7%2F746%3Frss%3D1 Conclusions Increased UACR is common in patients with heart failure, including non-diabetics. Urinary albumin creatinine ratio is independently associated with HbA1c and NT-proBNP, even in non-diabetic patients. Clinical Trial Registration: ClinicalTrials.gov NCT00219011 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=4977538 Mon, 27 Jun 2011 23:00:00 +0100 4977538 http://www.medworm.com/index.php?rid=4977537&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F7%2F737%3Frss%3D1 Conclusion Echocardiographic parameters including lateral E/e', LAVI, and Ard–Ad have the greatest value in diagnosing HFpEF. A brief strategy that included these three parameters had great diagnostic value and would be simple to use in clinic practice. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=4977537 Mon, 27 Jun 2011 23:00:00 +0100 4977537 http://www.medworm.com/index.php?rid=4977536&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F7%2F734%3Frss%3D1 Conclusion Our results demonstrate that plasma concentrations of Mstn are significantly increased in CHF patients and that Mstn correlates with biomarkers related to HF severity. Our study confirms the activation of Mstn in patients with heart failure. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=4977536 Mon, 27 Jun 2011 23:00:00 +0100 4977536 http://www.medworm.com/index.php?rid=4977535&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F7%2F726%3Frss%3D1 Conclusion Our data suggest that the combined use of hs-cTnT and copeptin might predict clinical outcome of patients with chronic stable heart failure. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=4977535 Mon, 27 Jun 2011 23:00:00 +0100 4977535 http://www.medworm.com/index.php?rid=4977534&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F7%2F718%3Frss%3D1 Conclusions Biomarkers reflecting remodelling (sST2), myonecrosis (hsTnT), and myocardial stretch (NT-proBNP) provide complementary prognostic information in patients with ADHF. When used together, these novel markers provide superior risk stratification. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=4977534 Mon, 27 Jun 2011 23:00:00 +0100 4977534 http://www.medworm.com/index.php?rid=4977533&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F7%2F711%3Frss%3D1 Conclusion In patients with ADHF, microvascular tissue perfusion is impaired even when global haemodynamic or laboratory signs of hypoperfusion are absent. Effective pharmacological treatment to decrease neurohumoral activation significantly improves microflow. Hypoperfusion in ADHF is potentially linked to neurohumoral activation with increased plasma levels of vasoconstrictors and sympatho-adrenergic activity. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=4977533 Mon, 27 Jun 2011 23:00:00 +0100 4977533 http://www.medworm.com/index.php?rid=4977532&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F7%2F700%3Frss%3D1 This article provides a concise review of the experimental and clinical CCM studies conducted to date with particular focus on areas of controversy and unexplored avenues of interest with this novel electrical therapy. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=4977532 Mon, 27 Jun 2011 23:00:00 +0100 4977532 http://www.medworm.com/index.php?rid=4977531&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F7%2F698%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=4977531 Mon, 27 Jun 2011 23:00:00 +0100 4977531 http://www.medworm.com/index.php?rid=4977530&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F7%2F694%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=4977530 Mon, 27 Jun 2011 23:00:00 +0100 4977530 http://www.medworm.com/index.php?rid=4977529&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F7%2F691%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=4977529 Mon, 27 Jun 2011 23:00:00 +0100 4977529 http://www.medworm.com/index.php?rid=4863967&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F6%2F681%3Frss%3D1 Conclusions By currently accepted standards of value for money in the UK; the addition of n-3 PUFA to optimal medical therapy for patients with heart failure is likely to be cost-effective. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=4863967 Tue, 24 May 2011 23:00:00 +0100 4863967 http://www.medworm.com/index.php?rid=4863966&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F6%2F670%3Frss%3D1 Conclusion Overall tolerability to target doses was comparable. The pattern of intolerance, however, was different: bradycardia occurred more often in the bisoprolol group, whereas pulmonary adverse events occurred more often in the carvedilol group. This study is registered with controlled-trials.com, number ISRCTN34827306. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=4863966 Tue, 24 May 2011 23:00:00 +0100 4863966 http://www.medworm.com/index.php?rid=4863965&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F6%2F664%3Frss%3D1 Conclusions This study suggests that exacerbation of LV compliance impairment, rather than of relaxation abnormality or vascular stiffening, plays a crucial role in the induction of HFpEF in DM patients regardless of the severity of DM and renal dysfunction. Anaemia and obesity may also contribute to the transition from asymptomatic stage to symptomatic HFpEF even without further progression of LV diastolic dysfunction. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=4863965 Tue, 24 May 2011 23:00:00 +0100 4863965 http://www.medworm.com/index.php?rid=4863964&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F6%2F656%3Frss%3D1 Conclusions Anaemia is an independent predictor of death or hospitalization for cardiovascular reasons among elderly patients with chronic HF and reduced or preserved/mildly reduced LVEF. Nebivolol does not affect haemoglobin values during follow-up. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=4863964 Tue, 24 May 2011 23:00:00 +0100 4863964 http://www.medworm.com/index.php?rid=4863963&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F6%2F651%3Frss%3D1 Conclusion Putamen structures showed global and localized volume reductions in HF over controls. The localized volume losses suggest deficits in motor and neuropsychological functions, which are evident in HF subjects, and may be due to hypoxic and ischaemic processes targeting these areas. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=4863963 Tue, 24 May 2011 23:00:00 +0100 4863963 http://www.medworm.com/index.php?rid=4863962&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F6%2F642%3Frss%3D1 Conclusion A short term in-hospital structured cardiovascular training programme reduces the ability of serum-derived factors to induce endothelial cell death in patients with CHF. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=4863962 Tue, 24 May 2011 23:00:00 +0100 4863962 http://www.medworm.com/index.php?rid=4863961&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F6%2F633%3Frss%3D1 Conclusion This study did not demonstrate significant LV volume differences >12 months between RV apical and BIV pacing for AV block. Thus, BIV pacing cannot be recommended as a routine treatment for AV block in these patients. However, the results encourage and inform the design of subsequent larger trials with higher power for detecting small volume changes. ClinicalTrials.gov Identifier: NCT00170326. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=4863961 Tue, 24 May 2011 23:00:00 +0100 4863961 http://www.medworm.com/index.php?rid=4863960&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F6%2F626%3Frss%3D1 Conclusion In this relatively small prospective study, PTH and vitamin D were independently associated with all cause and cardiovascular mortality in patients with HF. This was independent of other known risk factors such as eGFR, LVEF, NT-proBNP, and age. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=4863960 Tue, 24 May 2011 23:00:00 +0100 4863960 http://www.medworm.com/index.php?rid=4863959&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F6%2F619%3Frss%3D1 Conclusion A low 25(OH)D concentration is associated with a poor prognosis in HF patients. Activation of the RAS and inflammation may confer the adverse effects of low vitamin D levels. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=4863959 Tue, 24 May 2011 23:00:00 +0100 4863959 http://www.medworm.com/index.php?rid=4863958&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F6%2F611%3Frss%3D1 Conclusions The T-cell infiltrates in human DCMi are characterized by differential expression of functional T-cell markers indicating Th1, Treg, and CTLs, while no major role could be confirmed for Th17. The virus-associated differential TRBV dominance suggests an antiviral specificity of virus-induced T-cell responses in human DCMi. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=4863958 Tue, 24 May 2011 23:00:00 +0100 4863958 http://www.medworm.com/index.php?rid=4863957&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F6%2F602%3Frss%3D1 Conclusion Application of the TLR4 antagonist eritoran attenuates the development of cardiac hypertrophy possibly by a reduction in inflammatory and increase in anti-inflammatory cytokines. (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=4863957 Tue, 24 May 2011 23:00:00 +0100 4863957 http://www.medworm.com/index.php?rid=4863956&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F6%2F599%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=4863956 Tue, 24 May 2011 23:00:00 +0100 4863956 http://www.medworm.com/index.php?rid=4863955&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F6%2F597%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=4863955 Tue, 24 May 2011 23:00:00 +0100 4863955 http://www.medworm.com/index.php?rid=4863954&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F6%2F595%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=4863954 Tue, 24 May 2011 23:00:00 +0100 4863954 http://www.medworm.com/index.php?rid=4863953&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F6%2F584%3Frss%3D1 Pregnancy exposes women with inherited cardiomyopathies to increased risk for heart failure and arrhythmias. In this paper, we review the clinical course and management of pregnant women with the following inherited cardiomyopathies: hypertrophic cardiomyopathy, dilated cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, left ventricular non-compaction cardiomyopathy, and restrictive cardiomyopathy. We also discuss peripartum cardiomyopathy. Pregnancy is generally well tolerated in asymptomatic patients with inherited cardiomyopathies. However, worsening of the clinical condition can occur during pregnancy, despite intensive medical treatment. If prior cardiac events, poor functional class (New York Heart Association class III or IV), or advanced left ventricular systolic dysf... European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=4863953 Tue, 24 May 2011 23:00:00 +0100 4863953 http://www.medworm.com/index.php?rid=4863952&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F6%2F579%3Frss%3D1 Tumour markers are used for the screening, diagnosis, and stratification of cancer disease. Recently, the potential role of some tumour markers has also been explored in the context of heart failure. These include CA-125, CA 15-3, CA 19-9, carcinoembryonic antigen, alpha-feto protein, tissue polypeptide antigen, tissue polypeptide specific antigen, cytokeratin 19 fragment, and chromogranins. Of these markers, CA-125, a tumour antigen that is expressed on the surface of ovarian cancer cells and which is a well-established biomarker for monitoring ovarian cancer growth, has been investigated most extensively. Trials have consistently indicated that CA-125 could serve as both a diagnostic and prognostic biomarker of heart failure, although the pathophysiology remains to be established. In thi... European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=4863952 Tue, 24 May 2011 23:00:00 +0100 4863952 http://www.medworm.com/index.php?rid=4735820&cid=s_35541_7_f&fid=35541&url=http%3A%2F%2Feurjhf.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F13%2F5%2F577-a%3Frss%3D1 (Source: European Journal of Heart Failure) European Journal of Heart Failure journals http://www.medworm.com/rss/comments.php?id=4735820 Mon, 18 Apr 2011 23:00:00 +0100 4735820