MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Experimental Diabetes Research' source. Wed, 08 Feb 2012 15:08:57 +0100 http://www.medworm.com/index.php?rid=5667763&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fjeph%2F2012%2F156435%2F Healthy People 2020 aims to achieve health equity, eliminate disparities, and improve the health of all groups. Regular physical activity (PA) improves overall health and fitness and has the capability to reduce risk for chronic diseases. Identifying barriers which relate to the Hispanic population is important when designing PA interventions. Therefore, the purpose was to review existing PA interventions targeting Hispanic adults published between 1988 and 2011. This paper was limited to interventions which included more than 35% Hispanic adults (n=20). Most of the interventions were community based (n=16), although clinical, family-based, and faith-based settings were also represented. Interventions incorporated theory (n=16), with social cognitive theory and transtheoretical model being... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5667763 Wed, 08 Feb 2012 19:49:39 +0100 5667763 http://www.medworm.com/index.php?rid=5667762&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fjfsa%2F2012%2F202987%2F We introduce and study the concept of (p,k)-variation (1<p<∞, k∈N) of a real function on a compact interval. In particular, we prove that a function u:[a,b]→R has bounded (p,k)-variation if and only if u(k-1) is absolutely continuous on [a,b] and u(k) belongs to Lp[a,b]. Moreover, an explicit connection between the (p,k)-variation of u and the Lp-norm of u(k) is given which is parallel to the classical Riesz formula characterizing functions in the spaces RVp[a,b] and Ap[a,b]. This may also be considered as an alternative characterization of the one variable Sobolev space Wpk[a,b]. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5667762 Wed, 08 Feb 2012 19:49:39 +0100 5667762 http://www.medworm.com/index.php?rid=5667761&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fijac%2F2012%2F341260%2F Immunoimaging scanning probe microscopy was utilized for the low-level detection and quantification of biotinylated G4 poly(amidoamine) PAMAM dendrimers. Results were compared to those of high-performance liquid chromatography (HPLC) and found to provide a vastly improved analytical method for the low-level detection of dendrimers, improving the limit of detection by a factor of 1000 (LOD=2.5×10−13 moles). The biorecognition method is reproducible and shows high specificity and good accuracy. In addition, the capture assay platform shows a promising approach to patterning dendrimers for nanotechnology applications. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5667761 Wed, 08 Feb 2012 19:49:39 +0100 5667761 http://www.medworm.com/index.php?rid=5667760&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fmpe%2F2012%2F473847%2F The travel time of left-turning vehicles at signalized intersection was discussed. Under the assumption that the opposing through vehicles headway follows M3 distribution, the travel time model was established on the basis of gap theory and queue theory. Comparison was done with the common model based on the assumption that the opposing through vehicles headway follows negative exponential distribution. The results show that the model in this paper has stronger applicability and its most relative error is less than 15%. In addition, the sensitivity analysis was done. The results show that the opposing through flow rate has significant impact on travel time. The impact of left-turning flow rate and following headway is light when the opposing through flow rate is small, the threshold is... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5667760 Wed, 08 Feb 2012 19:49:39 +0100 5667760 http://www.medworm.com/index.php?rid=5667759&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fgrp%2F2012%2F875323%2F Conclusion. Ulcer presence/absence was considered the most significant predictor of post-ESD bleeding. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5667759 Wed, 08 Feb 2012 19:49:39 +0100 5667759 http://www.medworm.com/index.php?rid=5560788&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fddns%2F2012%2F745697%2F A discrete time two-nation arms race model involving a piecewise constant nonlinear control function is formulated and studied. By elementary but novel arguments, we are able to give a complete analysis of its asymptotic behavior when the threshold parameter in the control function varies from 0+ to ∞. We show that all solutions originated from positive initial values tend to limit one or two cycles. An implication is that when devastating weapons are involved, “terror equilibrium” can be achieved and escalated race avoided. It is hoped that our analysis will provide motivation for further studying of discrete-time equations with piecewise smooth nonlinearities. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5560788 Thu, 05 Jan 2012 15:46:41 +0100 5560788 http://www.medworm.com/index.php?rid=5560787&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fjcnc%2F2012%2F109685%2F CAC (Call Admission Control) plays a significant role in providing QoS (Quality of Service) in mobile wireless networks. In addition to much research that focuses on modified Mobile IP to get better efficient handover performance, CAC should be introduced to Mobile IP-based network to guarantee the QoS for users. In this paper, we propose a CAC scheme which incorporates multiple traffic types and adjusts the admission threshold dynamically using fuzzy control logic to achieve better usage of resources. The method can provide QoS in Mobile IPv6 networks with few modifications on MAP (Mobility Anchor Point) functionality and slight change in BU (Binding Update) message formats. According to the simulation results, the proposed scheme presents good performance of voice and video traffic at th... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5560787 Thu, 05 Jan 2012 15:46:41 +0100 5560787 http://www.medworm.com/index.php?rid=5495223&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fijmb%2F2011%2F248418%2F Q fever is an ubiquitous zoonosis caused by an resistant intracellular bacterium, Coxiella burnetii. In certain areas, Q fever can be a severe public health problem, and awareness of the disease must be promoted worldwide. Nevertheless, knowledge of Coxiella burnetii remains limited to this day. Its resistant (intracellular and environmental) and infectious properties have been poorly investigated. Further understanding of the interactions between the infected host and the bacteria is necessary. Domestic ruminants are considered as the main reservoir of bacteria. Infected animals shed highly infectious organisms in milk, feces, urine, vaginal mucus, and, very importantly, birth products. Inhalation is the main route of infection. Frequently asymptomatic in humans and animals, Q fever can c... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5495223 Tue, 13 Dec 2011 08:23:24 +0100 5495223 http://www.medworm.com/index.php?rid=5495222&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fam%2F2011%2F706164%2F In contrast to what is happening in the Internet-based scenario, the music market in the mobile scenario is far from being considered a large success. Several studies state that excessive downloading time and high cost are the main burdens. Motivated by the growth of social and mobile applications, in this paper we propose an approach that aims at reducing both the downloading time and the cost to get digital music when acquired in the mobile scenario. The proposed architecture exploits the usage of personal communication technologies embedded in cellphones (e.g., Bluetooth and Wi-Fi) to couple the current distribution model (mainly based on 3G networks), so as to provide a multichannel distribution model where users are free to redistribute digital music. The architecture includes a licen... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5495222 Tue, 13 Dec 2011 08:23:24 +0100 5495222 http://www.medworm.com/index.php?rid=5495221&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fjo%2F2011%2F365651%2F Previous reports demonstrate that the α2-integrin (α2) mediates pancreatic ductal adenocarcinoma (PDAC) cell interactions with collagens. We found that while well-differentiated cells use α2 exclusively to adhere and migrate on collagenI, poorly differentiated PDAC cells demonstrate reduced reliance on, or complete loss of, α2. Since well-differentiated PDAC lines exhibit reduced in vitro invasion and α2-blockade suppressed invasion of well-differentiated lines exclusively, we hypothesized that α2 may suppress the malignant phenotype in PDAC. Accordingly, ectopic expression of α2 retarded in vitro invasion and maintenance on collagenI exacerbated this effect. Affymetrix profiling revealed that kallikrein-related peptidase-5 (KLK5) was specif... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5495221 Tue, 13 Dec 2011 08:23:24 +0100 5495221 http://www.medworm.com/index.php?rid=5495220&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fije%2F2011%2F707928%2F Recent reports point out the importance of the complex GK-GKRP in controlling glucose and lipid homeostasis. Several GK mutations affect GKRP binding, resulting in permanent activation of the enzyme. We hypothesize that hepatic overexpression of a mutated form of GK, GKA456V, described in a patient with persistent hyperinsulinemic hypoglycemia of infancy (PHHI) and could provide a model to study the consequences of GK-GKRP deregulation in vivo. GKA456V was overexpressed in the liver of streptozotocin diabetic mice. Metabolite profiling in serum and liver extracts, together with changes in key components of glucose and lipid homeostasis, were analyzed and compared to GK wild-type transfected livers. Cell compartmentalization of the mutant but not the wild-type GK was clearly affected in viv... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5495220 Tue, 13 Dec 2011 08:23:24 +0100 5495220 http://www.medworm.com/index.php?rid=5477115&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fmpe%2F2011%2F759418%2F This paper addresses the linehaul-feeder vehicle routing problem with virtual depots and time windows (LFVRPTW). Small and large vehicles deliver services to customers within time constraints; small vehicles en route may reload commodities from either the physical depot or from the larger vehicle at a virtual depot before continuing onward. A two-stage solution heuristic involving Tabu search is proposed to solve this problem. The test results show that the LFVRPTW performs better than the vehicle routing problem with time windows in terms of both objective value and the number of small vehicles dispatched. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5477115 Wed, 07 Dec 2011 08:14:59 +0100 5477115 http://www.medworm.com/index.php?rid=5477114&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fsrt%2F2011%2F198518%2F Conclusions. The parallel thrombolysis protocol successfully improved the median door-to-needle time to below the guideline-recommended 60 minutes. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5477114 Wed, 07 Dec 2011 08:14:59 +0100 5477114 http://www.medworm.com/index.php?rid=5477113&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Faaa%2F2011%2F321428%2F We provide a sufficient condition for constructing a class of compactly supported refinable functions with componentwise polynomial property in ℝ2. An iteration algorithm is developed to compute the polynomial on each component of the functions' support. Finally, two examples for constructing the symmetric refinable componentwise polynomial functions are given. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5477113 Wed, 07 Dec 2011 08:14:59 +0100 5477113 http://www.medworm.com/index.php?rid=5458578&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fjcnc%2F2011%2F195685%2F We present Alert, a MAC protocol for collecting event-triggered urgent messages from a group of sensor nodes with minimum latency and without requiring any cooperation or prescheduling among the senders or between senders and receiver during protocol execution. Alert is designed to handle multiple simultaneous messages from different nodes efficiently and reliably, minimizing the overall delay to collect all messages along with the delay to get the first message. Moreover, the ability of the network to handle a large number of simultaneous messages does not come at the cost of excessive delays when only a few messages need to be handled. We analyze Alert and evaluate its feasibility and performance with an implementation on commodity hardware. We further compare Alert with existing approac... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5458578 Thu, 01 Dec 2011 08:42:37 +0100 5458578 http://www.medworm.com/index.php?rid=5361572&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fheprt%2F2011%2F524027%2F Conclusion. HBeAg status, age, ethnic origin with longitudinal assessment of LFTs and viral load should be studied in patients with “normal ALT” at the upper end of normal range (ALT 20–40 IU/L) to appropriately classify patients and identify patients for liver fibrosis assessment to inform treatment decisions. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5361572 Tue, 01 Nov 2011 00:27:02 +0100 5361572 http://www.medworm.com/index.php?rid=5361571&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Faaa%2F2011%2F370104%2F Let X be a normed space and Y a sequentially complete Hausdorff topological vector space over the field Q of rational numbers. Let D1={(x,y)∈X×X:∥x∥+∥y∥≥d}, and D2={(x,y)∈X×X:∥x∥+∥y∥<d} where d>0. We prove that the Pexiderized Jensen functional equation is stable for functions defined on D1(D2), and taking values in Y. We consider also the Pexiderized Cauchy functional equation. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5361571 Tue, 01 Nov 2011 00:27:02 +0100 5361571 http://www.medworm.com/index.php?rid=5361570&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fccrp%2F2011%2F159182%2F (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5361570 Tue, 01 Nov 2011 00:27:02 +0100 5361570 http://www.medworm.com/index.php?rid=5361569&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fame%2F2011%2F408524%2F An ANN model is proposed to predict the impurity concentration in solid diffusion process when the diffusion coefficient is not known using back-propagation learning technique based on insufficient data for analytical solution. The proposed model was very competitive against the analytical method as the results showed high-performance results with minimal amount of error comparing to the analytical method. Moreover, the proposed ANN model can be used where the analytical methods cannot as in some situations where the diffusion coefficient is not available (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5361569 Tue, 01 Nov 2011 00:27:02 +0100 5361569 http://www.medworm.com/index.php?rid=5361568&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fijs%2F2011%2F527642%2F We have investigated the optical properties of InAs/GaAs (113)A quantum dots grown by molecular beam epitaxy (MBE) capped by (In,Ga)As. Reflection high-energy electron diffraction (RHEED) is used to investigate the formation process of InAs quantum dots (QDs). A broadening of the PL emission due to size distribution of the dots, when InAs dots are capped by GaAs, was observed. A separation between large and small quantum dots, when they are encapsulated by InGaAs, was shown due to hydrostatic and biaxial strain action on large and small dots grown under specifically growth conditions. The PL polarization measurements have shown that the small dots require an elongated form, but the large dots present a quasi-isotropic behavior. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5361568 Tue, 01 Nov 2011 00:27:02 +0100 5361568 http://www.medworm.com/index.php?rid=5361567&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fcrim%2Fpsychiatry%2F2011%2F638506%2F We report the followup medical history of a patient with corpus callosum aplasia (or agenesis) who was continuously treated with ECT over three years. First, he improved considerably after a series of ECT, but relapses of catatonia made a continuous, weekly ECT necessary. Due to the severity of the brain malformation, an add-on medication with benzodiazepines and second generation antipsychotics was necessary to treat catatonic symptoms. This case emphasises the benefits of long-term ECT in oligophrenic patients. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5361567 Tue, 01 Nov 2011 00:27:02 +0100 5361567 http://www.medworm.com/index.php?rid=5361566&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fijde%2F2011%2F582512%2F We employ the bifurcation method of planar dynamical systems and qualitative theory of polynomial differential systems to derive new bounded traveling-wave solutions for a variant of the K(3,2) equation. For the focusing branch, we obtain hump-shaped and valley-shaped solitary-wave solutions and some periodic solutions. For the defocusing branch, the nonexistence of solitary traveling wave solutions is shown. Meanwhile, some periodic solutions are also obtained. The results presented in this paper supplement the previous results. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5361566 Tue, 01 Nov 2011 00:27:02 +0100 5361566 http://www.medworm.com/index.php?rid=5361565&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fijd%2F2011%2F413639%2F The present study was undertaken to evaluate the prevalence of radiographic changes in the condylar morphology and its association with age, clinical signs and symptoms of temporomandibular dysfunction and dentition status and also to evaluate the intra examiner and inter examiner reliability in assessing condylar changes using panoramic radiographs. A total of 75 subjects were recruited for the study. They were divided into 3 age groups. 20–40 yrs (Group A), 41–60 yrs (Group B) and 61 yrs and above (Group C). In each age group 25 subjects were evaluated both clinically and radiographically. The prevalence of radiographic changes in condylar morphology and symptoms of temporomandibular dysfunction was 81.3% and 18.6%, respectively. Radiographic abno... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5361565 Tue, 01 Nov 2011 00:27:02 +0100 5361565 http://www.medworm.com/index.php?rid=5361564&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fmpe%2F2011%2F103437%2F This paper deals with the Multiobjective Linear Transportation Problem that has fuzzy cost coefficients. In the solution procedure, many objectives may conflict with each other; therefore decision-making process becomes complicated. And also due to the fuzziness in the costs, this problem has a nonlinear structure. In this paper, fuzziness in the objective functions is handled with a fuzzy programming technique in the sense of multiobjective approach. And then we present a compensatory approach to solve Multiobjective Linear Transportation Problem with fuzzy cost coefficients by using Werner's μand operator. Our approach generates compromise solutions which are both compensatory and Pareto optimal. A numerical example has been provided to illustrate the problem. (Source: Experi... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5361564 Tue, 01 Nov 2011 00:27:02 +0100 5361564 http://www.medworm.com/index.php?rid=5361563&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Faaa%2F2011%2F610232%2F This paper investigates the sampling analysis associated with discontinuous Sturm-Liouville problems with eigenvalue parameters in two boundary conditions and with transmission conditions at the point of discontinuity. We closely follow the analysis derived by Fulton (1977) to establish the needed relations for the derivations of the sampling theorems including the construction of Green's function as well as the eigenfunction expansion theorem. We derive sampling representations for transforms whose kernels are either solutions or Green's functions. In the special case, when our problem is continuous, the obtained results coincide with the corresponding results in the work of Annaby and Tharwat (2006). (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5361563 Tue, 01 Nov 2011 00:27:02 +0100 5361563 http://www.medworm.com/index.php?rid=5361562&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fijmms%2F2011%2F686139%2F The aim of this paper is the variational study of the contact with adhesion between an elastic material and a rigid foundation in the quasistatic process where the deformations are supposed to be small. The behavior of this material is modelled by a nonlinear elastic law and the contact is modelled with Signorini's conditions and adhesion. The evolution of bonding field is described by a nonlinear differential equation. We derive a variational formulation of the mechanical problem, and we prove the existence and uniqueness of the weak solution using a theorem on variational inequalities, the theorem of Cauchy-Lipschitz, a lemma of Gronwall, as well as the fixed point of Banach. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5361562 Tue, 01 Nov 2011 00:27:02 +0100 5361562 http://www.medworm.com/index.php?rid=5361561&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fmpe%2F2011%2F341989%2F A numerical method for solving nonlinear Fredholm integral equations of second kind is proposed. The Fredholm-type equations, which have many applications in mathematical physics, are then considered. The method is based upon hybrid function approximate. The properties of hybrid of block-pulse functions and Chebyshev series are presented and are utilized to reduce the computation of nonlinear Fredholm integral equations to a system of nonlinear. Some numerical examples are selected to illustrate the effectiveness and simplicity of the method. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5361561 Tue, 01 Nov 2011 00:27:02 +0100 5361561 http://www.medworm.com/index.php?rid=5361560&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fape%2F2011%2F239061%2F A unique direct driven permanent magnet synchronous generator has been designed and constructed. Results from simulations as well as from the first experimental tests are presented. The generator has been specifically designed to be directly driven by a vertical axis wind turbine and has an unusually low reactance. Generators for wind turbines with full variable speed should maintain a high efficiency for the whole operational regime. Furthermore, for this application, requirements are placed on high generator torque capability for the whole operational regime. These issues are elaborated in the paper and studied through simulations. It is shown that the generator fulfils the expectations. An electrical control can effectively substitute a mechanical pitch control. Furthermore, results fro... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5361560 Tue, 01 Nov 2011 00:27:02 +0100 5361560 http://www.medworm.com/index.php?rid=5361559&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fjam%2F2011%2F164371%2F Transitivity of generalized fuzzy matrices over a special type of semiring is considered. The semiring is called incline algebra which generalizes Boolean algebra, fuzzy algebra, and distributive lattice. This paper studies the transitive incline matrices in detail. The transitive closure of an incline matrix is studied, and the convergence for powers of transitive incline matrices is considered. Some properties of compositions of incline matrices are also given, and a new transitive incline matrix is constructed from given incline matrices. Finally, the issue of the canonical form of a transitive incline matrix is discussed. The results obtained here generalize the corresponding ones on fuzzy matrices and lattice matrices shown in the references. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5361559 Tue, 01 Nov 2011 00:27:02 +0100 5361559 http://www.medworm.com/index.php?rid=5361558&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fjam%2F2011%2F218078%2F This paper presents a 1-opt heuristic approach to solve resource allocation/reallocation problem which is known as 0/1 multichoice multidimensional knapsack problem (MMKP). The intercept matrix of the constraints is employed to find optimal or near-optimal solution of the MMKP. This heuristic approach is tested for 33 benchmark problems taken from OR library of sizes upto 7000, and the results have been compared with optimum solutions. Computational complexity is proved to be O(klmn2) of solving heuristically MMKP using this approach. The performance of our heuristic is compared with the best state-of-art heuristic algorithms with respect to the quality of the solutions found. The encouraging results especially for relatively large-size test problems indicate that this heuristic approach c... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5361558 Tue, 01 Nov 2011 00:27:02 +0100 5361558 http://www.medworm.com/index.php?rid=5361557&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fijped%2F2011%2F524520%2F Iron polymaltose complex (IPC) offers similar efficacy with superior tolerability to ferrous sulfate in adults, but randomized trials in children are rare. In a prospective, open-label, 4-month study, 103 children aged >6 months with iron deficiency anemia (IDA) were randomized to IPC once daily or ferrous sulfate twice daily, (both 5 mg iron/kg/day). Mean increases in Hb to months 1 and 4 with IPC were 1.2±0.9 g/dL and 2.3±1.3 g/dL, respectively, (both P=0.001 versus baseline) and 1.8±1.7 g/dL and 3.0±2.3 g/dL with ferrous sulfate (both P=0.001 versus baseline) (n.s. between groups). Gastrointestinal adverse events occurred in 26.9% and 50.9% of IPC and ferrous sulfate patients, respectively (P=0.012). Mean... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5361557 Tue, 01 Nov 2011 00:27:02 +0100 5361557 http://www.medworm.com/index.php?rid=5361556&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fjnume%2F2011%2F748361%2F Over the last decade, several epidemiological studies based on food frequency questionnaires suggest that omega-3 polyunsaturated fatty acids could have a protective role in reducing the onset and progression of retinal diseases. The retina has a high concentration of omega-3, particularly DHA, which optimizes fluidity of photoreceptor membranes, retinal integrity, and visual function. Furthermore, many studies demonstrated that DHA has a protective, for example antiapoptotic, role in the retina. From a nutritional point of view, it is known that western populations, particularly aged individuals, have a higher than optimal omega-6/omega-3 ratio and should enrich their diet with more fish consumption or have DHA supplementation. This paper underscores the potential beneficial effect of ome... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5361556 Tue, 01 Nov 2011 00:27:02 +0100 5361556 http://www.medworm.com/index.php?rid=5361555&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcrim%2F2011%2F858672%2F Opioids are a mainstay of treatment for moderate to severe cancer pain. At present, oxycodone has fewer adverse effects compared to morphine and is widely used for cancer pain therapy. The adverse effects of oxycodone are similar to morphine and include constipation, nausea, and sedation. However, acute abdominal pain is rarely seen. Here, we describe a cancer patient presenting with acute abdomen with stercoral diarrhea. A 54-year-old man with squamous cell carcinoma of the external auditory canal had been taking oxycodone for pain relief. The patient had taken oxycodone for several months and had never complained of either diarrhea or constipation. After an increase in the dosage of oxycodone, he complained of abdominal distension and constipation. After being administered a laxative, he... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5361555 Tue, 01 Nov 2011 00:27:02 +0100 5361555 http://www.medworm.com/index.php?rid=5361554&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fijo%2F2011%2F737684%2F Sum-frequency generation of UV pulses exceeding 25 mJ and with beam quality M2∼5 has been demonstrated by mixing the third harmonic pulses of a flash lamp pumped 1.06 μm Nd:YAG laser with 1.7 μm pulses from an optical parametric oscillator pumped by the same laser in a compact setup. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5361554 Tue, 01 Nov 2011 00:27:02 +0100 5361554 http://www.medworm.com/index.php?rid=5361553&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fcrim%2Fdm%2F2011%2F412684%2F Imiquimod is an immunomodulator with both antitumor and antiviral properties. It is currently available in two cream formulations as Aldara (imiquimod 5%) and the newly approved Zyclara (imiquimod 3.75%). Imiquimod has been associated with localized erythema, crusting, and scaling at the site of application. However, more severe generalized skin eruptions including erythema multiforme, psoriasis, and hyperpigmentation have been described. The newly approved imiquimod 3.75% cream is a presumably safer alternative due to its lower concentration. This paper describes the development of generalized acantholytic pityriasis rubra pilaris after the treatment of an actinic keratosis on the forehead with imiquimod 3.75% cream. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5361553 Tue, 01 Nov 2011 00:27:02 +0100 5361553 http://www.medworm.com/index.php?rid=5361552&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fcrim%2Fotolaryngology%2F2011%2F786202%2F We report a case of radiation-induced osteosarcoma of the ethmoid sinus 9 years after initial exposure. We describe the clinical presentation, the radiological findings, and the management. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5361552 Tue, 01 Nov 2011 00:27:02 +0100 5361552 http://www.medworm.com/index.php?rid=5361551&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fahep%2F2011%2F649828%2F This paper presents the results of experimental investigations into the current-voltage characteristics of a planar diode with an explosive emission cathode made from graphite. Studies were performed using a TEU-500 pulsed electron accelerator (350–500 keV, 100 ns, 250 J per pulse). Duration of diode operation, in a mode when electron current is limited by the emissive ability of the graphite cathode, is 15–20 ns. The contribution of the cathode periphery to total electron current appears only as an increase in the emissive surface area due to an expansion of explosive plasma. Investigations of an ion diode with a graphite cathode (plane and focusing geometry) were also carried out. Experiments were performed using a TEMP-4M ion accelerator, which fo... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5361551 Tue, 01 Nov 2011 00:27:02 +0100 5361551 http://www.medworm.com/index.php?rid=5361550&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fvmi%2F2011%2F328307%2F Newly emerging infectious diseases (nEIDs) have increased rapidly presenting alarming challenges to global health. We argue that for effective management of global health a basic strategy should include at least three essential tactical forms: actions of a directly focused nature, institutional coordination, and disciplinary integration in approaches to health management. Each level of action is illustrated with examples from the livestock sector in Asia. No clear example of all three tactical forms in place can be found from developing countries where food security is a significant threat although Vietnam is developing a comprehensive strategy. Finally, an ecosystem health approach to global health management is advocated; such an approach moves away from the traditional single disciplina... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5361550 Tue, 01 Nov 2011 00:27:02 +0100 5361550 http://www.medworm.com/index.php?rid=5361549&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fabi%2F2011%2F657341%2F Typically, next-generation resequencing projects produce large lists of variants. NovelSNPer is a software tool that permits fast and efficient processing of such output lists. In a first step, NovelSNPer determines if a variant represents a known variant or a previously unknown variant. In a second step, each variant is classified into one of 15 SNP classes or 19 InDel classes. Beside the classes used by Ensembl, we introduce POTENTIAL_START_GAINED and START_LOST as new functional classes and present a classification scheme for InDels. NovelSNPer is based upon the gene structure information stored in Ensembl. It processes two million SNPs in six hours. The tool can be used online or downloaded. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5361549 Tue, 01 Nov 2011 00:27:02 +0100 5361549 http://www.medworm.com/index.php?rid=5361548&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fijelc%2F2011%2F864358%2F Chlorpromazine was used as a homogeneous electrocatalyst in the oxidation of captopril. The anodic peak current of chlorpromazine was increased substantially in the presence of low concentrations of captopril (pH 4). Cyclic voltammetry and chronoamperometry were used to study the kinetics of the catalytic electron transfer reaction. The values of electron transfer coefficient (α) and catalytic rate constant (kcat) were estimated to be 0.34 and 8.48×102 M−1 sec−1, respectively. Linear sweep voltammetry was used for the determination of captopril in the presence of chlorpromazine. A linear calibration curve was obtained in the concentration range of captopril of 10.0–300.0 μM, with a limit of detection of 3.65 μM. Th... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5361548 Tue, 01 Nov 2011 00:27:02 +0100 5361548 http://www.medworm.com/index.php?rid=5361547&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fjp%2F2011%2F634240%2F We tested the hypothesis that, in acute metabolic acidemia, the fetal left ventricle (LV) has the capacity to increase its contractility in response to angiotensin II infusion. Eleven ewes and their fetuses were instrumented at 127–138/145 days of gestation. The effect of angiotensin II on fetal LV function was assessed using intraventricular pressure catheter and tissue Doppler imaging (TDI). Angiotensin II increased fetal arterial blood pressure, whereas pH and pO2 decreased. The heart rate and systemic venous pressure were not affected significantly. The LV end-diastolic and end-systolic pressures, as well as dP/dtmax, increased. The TDI-derived LV longitudinal myocardial isovolumic contraction velocity and its acceleration and velocity during early filling were higher than those ... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5361547 Tue, 01 Nov 2011 00:27:02 +0100 5361547 http://www.medworm.com/index.php?rid=5361546&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Faaa%2F2011%2F493639%2F By means of the fixed point theory of strict set contraction operators, we establish a new existence theorem on multiple positive solutions to a singular boundary value problem for second-order impulsive differential equations with periodic boundary conditions in a Banach space. Moreover, an application is given to illustrate the main result. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5361546 Tue, 01 Nov 2011 00:27:02 +0100 5361546 http://www.medworm.com/index.php?rid=5348521&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fijbm%2F2011%2F737054%2F Supracondylar humerus fracture (SCHF) is one of the commonest elbow fractures in children. It is common injury for children with age from four to fourteen. In current study, the finite element technique is used to evaluate two techniques, namely, parallel and crossed K-wire fixation for treatment of SCHF, using K-wire fixation. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5348521 Wed, 26 Oct 2011 19:24:29 +0100 5348521 http://www.medworm.com/index.php?rid=5348520&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fjam%2F2011%2F262316%2F We investigate the asymptotic behavior of the solutions of a neutral type difference equation of the form Δ[x(n)+cx(τ(n))]+p(n)x(σ(n))=0, where τ(n) is a general retarded argument, σ(n) is a general deviated argument (retarded or advanced), c∈ℝ, (p(n))n≥0 is a sequence of positive real numbers such that p(n)≥p, p∈ℝ+, and Δ denotes the forward difference operator Δx(n)=x(n+1)−x(n). Also, we examine the asymptotic behavior of the solutions in case they are continuous and differentiable with respect to c. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5348520 Wed, 26 Oct 2011 19:24:29 +0100 5348520 http://www.medworm.com/index.php?rid=5348519&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fmse%2F2011%2F138143%2F We examine a simulation model for polymer extrusion filters and determine its sensitivity to filter parameters. The simulator is a three-dimensional, time-dependent discretization of a coupled system of nonlinear partial differential equations used to model fluid flow and debris transport, along with statistical relationships that define debris distributions and retention probabilities. The flow of polymer fluid, and suspended debris particles, is tracked to determine how well a filter performs and how long it operates before clogging. A filter may have multiple layers, characterized by thickness, porosity, and average pore diameter. In this work, the thickness of each layer is fixed, while the porosities and pore diameters vary for a two-layer and three-layer study. The effects of porosit... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5348519 Wed, 26 Oct 2011 19:24:29 +0100 5348519 http://www.medworm.com/index.php?rid=5348518&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fijfr%2F2011%2F320170%2F Loggers play a critical role in the sustainable production of wood and paper products, and harvesting activities contribute to economic health and viability of many Upper Midwest communities in the United States. If the logging sector is unable to procure wood efficiently and economically from an increasingly parcelized land base, the competitive ability of the forest industry could be jeopardized. Little is known about the functions of the logging sector related to the forest resource land base on which they depend, and it is imperative to improve our understanding of this important part of the forest industry. The purpose of this study was to determine prospective attitudes about the future of the logging industry and how trends in forestland parcelization and harvesting mechanization ar... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5348518 Wed, 26 Oct 2011 19:24:29 +0100 5348518 http://www.medworm.com/index.php?rid=5348517&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Farp%2F2011%2F271539%2F Recent publications suggest that target end-tidal carbon dioxide concentrations should be higher than values currently considered as acceptable. This paper presents evidence that end-tidal carbon dioxide values higher than concentrations that are currently targeted result in improved patient outcomes and are associated with a reduced incidence of postoperative complications. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5348517 Wed, 26 Oct 2011 19:24:29 +0100 5348517 http://www.medworm.com/index.php?rid=5348516&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fcrim%2Fradiology%2F2011%2F415476%2F A 49-year-old male with known history of end-stage renal disease (ESRD) presents with an intraoral exophytic mass of the right mandible. This lesion was given a histologic diagnosis of a Brown tumor. Purpose. To allow physicians to include this lesion in a differential diagnosis when evaluating patients with primary, secondary, or tertiary hyperparathyroidism. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5348516 Wed, 26 Oct 2011 19:24:29 +0100 5348516 http://www.medworm.com/index.php?rid=5348515&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fijd%2F2011%2F834151%2F This study investigated the inhibitory effect of probiotic Enterococcus faecium WB2000 on biofilm formation by cariogenic streptococci. The ability of E. faecium WB2000 and JCM5804 and Enterococcus faecalis JCM5803 to inhibit biofilm formation by seven laboratory oral streptococcal strains and 13 clinical mutans streptococcal strains was assayed. The Enterococcal strains inhibited biofilm formation in dual cultures with the mutans streptococcal strains Streptococcus mutans Xc and Streptococcus sobrinus JCM5176 (P<0.05), but not with the noncariogenic streptococcal strains. Enterococcus faecium WB2000 inhibited biofilm formation by 90.0% (9/10) of the clinical S. mutans strains and 100% (3/3) of the clinical S. sobrinus strains. After culturing, the pH did not differ between ... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5348515 Wed, 26 Oct 2011 19:24:29 +0100 5348515 http://www.medworm.com/index.php?rid=5348514&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fchol%2F2011%2F314234%2F We used the dataset from one medical center in Taiwan to explore the prevalence of dyslipidemia, which included 2695 subjects receiving private health checkups in 2003-2004. The overall prevalence of hypercholesterolemia was 53.3% in men and 48.2% in women (P=0.008). The overall prevalence of hypertriglyceridemia was 29.3% in men and 13.7% in women (P<0.001). The overall prevalence of elevated LDL level was 50.7% in men and 37.9% in women (P<0.001). The overall prevalence of low HDL level was 47.4% in men and 53% in women (P=0.004). (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5348514 Wed, 26 Oct 2011 19:24:29 +0100 5348514 http://www.medworm.com/index.php?rid=5348513&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fnrp%2F2011%2F501790%2F Recognizing the emotional labour underlying interprofessional collaborations (IPCs) could be considered a crucial step towards building a cohesive nursing team. Although IPCs between registered nurses (RNs) and licensed practical nurses (LPNs) have been linked to quality nursing care, little is known about the emotions experienced by LPNs during their interactions with RNs or those factors that influence IPCs. A questionnaire administered to 309 LPNs found that (1) the professional identity of LPNs has evolved into a that of a unique social group; (2) LPNs define IPC as an interpersonal process of exploring similar or dissimilar assessments of a patient's status with RNs and, together, establishing a course of nursing actions; (3) the primary organizational factor facilitating I... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5348513 Wed, 26 Oct 2011 19:24:29 +0100 5348513 http://www.medworm.com/index.php?rid=5348512&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fppar%2F2011%2F753917%2F The objective of this study was to investigate if ω-6 lipids modulated the early growth response-1 (Egr-1)/PPAR crosstalk thereby altering vascular function. Rat aortic smooth muscle cells (RASMCs) were exposed to ω-6 lipids, linoleic acid (LA), or its oxidized form, 13-HPODE (OxLA) in the presence or absence of a PPARα antagonist (MK886) or PPARγ antagonist (GW9662) or PPAR-specific siRNA. Our results demonstrate that ω-6 lipids, induced Egr-1 and monocyte chemotactic protein-1 (MCP-1) mRNA and protein levels at the acute phase (1–4 hrs) when PPARα was downregulated and at subacute phase (4–12 hrs) by modulating PPARγ, thus resulting in altered monocyte adhesion to RASMCs. We provide novel insights into the mechanism of... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5348512 Wed, 26 Oct 2011 19:24:29 +0100 5348512 http://www.medworm.com/index.php?rid=5348511&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fddns%2F2011%2F153082%2F This paper is concerned with the existence of nontrivial periodic solutions and positive periodic solutions to a nonlinear second-order difference equation. Under some conditions concerning the first positive eigenvalue of the linear equation corresponding to the nonlinear second-order equation, we establish the existence results by using the topological degree and fixed point index theories. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5348511 Wed, 26 Oct 2011 19:24:29 +0100 5348511 http://www.medworm.com/index.php?rid=5348510&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fmrt%2F2011%2F932895%2F This study assessed using microscopy, monthly dosing and the standard two-dose regimen among 259 pregnant women attending antenatal clinics in Lagos, Nigeria that consented 122 in the two-dose arm (Arm A) and 137 in the monthly dose arm (Arm B). Baseline parasitaemia in the two groups was 5 (4.1%) and 3 (2.2%) in Arms A and B, respectively. Few of the women developed parasitaemia after the initial SP dose in Arms A 4 (3.3%) and B 2 (1.5%). However, none of the women had malaria infection after the second dose in both Arms. Although IPTP-SP is suggestive of protecting the women from malaria infection, there was no significant difference observed between the two dosing schemes. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5348510 Wed, 26 Oct 2011 19:24:29 +0100 5348510 http://www.medworm.com/index.php?rid=5348509&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fads%2F2011%2F167672%2F Motivated by Carlson-Shaffer linear operator, we define here a new generalized linear operator. Using this operator, we define a class of analytic functions in the unit disk U. For this class, a majorization problem of analytic functions is discussed. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5348509 Wed, 26 Oct 2011 19:24:29 +0100 5348509 http://www.medworm.com/index.php?rid=5348508&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Facisc%2F2011%2F183764%2F A study is presented to model surface roughness in end milling process. Three types of intelligent networks have been considered. They are (i) radial basis function neural networks (RBFNs), (ii) adaptive neurofuzzy inference systems (ANFISs), and (iii) genetically evolved fuzzy inference systems (G-FISs). The machining parameters, namely, the spindle speed, feed rate, and depth of cut have been used as inputs to model the workpiece surface roughness. The goal is to get the best prediction accuracy. The procedure is illustrated using experimental data of end milling 6061 aluminum alloy. The three networks have been trained using experimental training data. After training, they have been examined using another set of data, that is, validation data. Results are compared with previously publis... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5348508 Wed, 26 Oct 2011 19:24:29 +0100 5348508 http://www.medworm.com/index.php?rid=5348507&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fcrim%2Fendocrinology%2F2011%2F941738%2F We present a case of a 71-year-old female referred for evaluation and treatment of acromegaly. Questioning revealed she was experiencing facial palsy, visual disturbances, and syncopal spells for several weeks. When laboratory evaluation showed elevated somatomedin (IGF-I) levels and an oral glucose tolerance test failed to demonstrate any suppression of her growth hormone (GH) values, an MRI of the pituitary revealed a sellar mass. A presumptive diagnosis of pituitary adenoma was established. The patient underwent transsphenoidal resection of the sellar mass, which proved to be a large B-cell lymphoma (Stage I-E) associated with areas of adenoma and lymphocytic hypophysitis. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5348507 Wed, 26 Oct 2011 19:24:29 +0100 5348507 http://www.medworm.com/index.php?rid=5348506&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2011%2F514059%2F Conclusions. The presence of stereotypies could be associated with a dysexecutive profile in AD patients. These results shed light on the role of frontal circuitry in the expression of motor symptoms in AD and prompt for further research that will contribute to the differential diagnosis both of different subtypes of AD and other types of dementia. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5348506 Wed, 26 Oct 2011 19:24:29 +0100 5348506 http://www.medworm.com/index.php?rid=5348505&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fau%2F2011%2F538750%2F When urethral catheterisation is difficult or impossible in spinal cord injury patients, flexible cystoscopy and urethral catheterisation over a guide wire can be performed on the bedside, thus obviating the need for emergency suprapubic cystostomy. Spinal cord injury patients, who undergo flexible cystoscopy and urethral catheterisation over a guide wire, may develop potentially serious complications. (1) Persons with lesion above T-6 are susceptible to develop autonomic dysreflexia during cystoscopy and urethral catheterisation over a guide wire; nifedipine 5–10 milligrams may be administered sublingually just prior to the procedure to prevent autonomic dysreflexia. (2) Spinal cord injury patients are at increased risk for getting urine infections as compared to able-bodied indiv... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5348505 Wed, 26 Oct 2011 19:24:29 +0100 5348505 http://www.medworm.com/index.php?rid=5348504&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fijde%2F2011%2F463416%2F This paper is concerned with time-periodic solution of the weakly dissipative Camassa-Holm equation with a periodic boundary condition. The existence and uniqueness of a time periodic solution is presented. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5348504 Wed, 26 Oct 2011 19:24:29 +0100 5348504 http://www.medworm.com/index.php?rid=5348503&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fart%2F2011%2F903480%2F Conclusions. Good mental health may be an indicator of HCV treatment adherence readiness, which is in turn associated with treatment completion and response, but further research is needed with new HCV treatments emerging. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5348503 Wed, 26 Oct 2011 19:24:29 +0100 5348503 http://www.medworm.com/index.php?rid=5348502&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Faaa%2F2011%2F843292%2F We study one-signed periodic solutions of the first-order functional differential equation u'(t)=-a(t)u(t)+λb(t)f(u(t-τ(t))), t∈R by using global bifurcation techniques. Where a,b∈C(R,[0,∞)) are ω-periodic functions with ∫0ωa(t)dt>0, ∫0ωb(t)dt>0, τ is a continuous ω-periodic function, and λ>0 is a parameter. f∈C(R,R) and there exist two constants s2<0<s1 such that f(s2)=f(0)=f(s1)=0, f(s)>0 for s∈(0,s1)∪(s1,∞) and f(s)<0 for s∈(-∞,s2)∪(s2,0). (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5348502 Wed, 26 Oct 2011 19:24:29 +0100 5348502 http://www.medworm.com/index.php?rid=5348501&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fgrp%2F2011%2F161358%2F Gastrointestinal (GI) dysfunction has been reported in a substantial number of children with autism spectrum disorders (ASD). Activation of the mucosal immune response and the presence of abnormal gut microbiota are repeatedly observed in these children. In children with ASD, the presence of GI dysfunction is often associated with increased irritability, tantrums, aggressive behaviour, and sleep disturbances. Moreover, modulating gut bacteria with short-term antibiotic treatment can lead to temporary improvement in behavioral symptoms in some individuals with ASD. Probiotics can influence microbiota composition and intestinal barrier function and alter mucosal immune responses. The administration of probiotic bacteria to address changes in the microbiota might, therefore, be a useful novel... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5348501 Wed, 26 Oct 2011 19:24:29 +0100 5348501 http://www.medworm.com/index.php?rid=5348500&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fijmms%2F2011%2F387429%2F We provide a new mathematical technique leading to the construction of the exact parametric or closed form solutions of the classes of Abel's nonlinear differential equations (ODEs) of the first kind. These solutions are given implicitly in terms of Bessel functions of the first and the second kind (Neumann functions), as well as of the free member of the considered ODE; the parameter ν being introduced furnishes the order of the above Bessel functions and defines also the desired solutions of the considered ODE as one-parameter family of surfaces. The nonlinear initial or boundary value problems are also investigated. Finally, introducing a relative mathematical methodology, we construct the exact parametric or closed form solutions for several degenerate Abel's equation of the fir... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5348500 Wed, 26 Oct 2011 19:24:29 +0100 5348500 http://www.medworm.com/index.php?rid=5348499&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fcrim%2Fhematology%2F2011%2F939080%2F We report the case of a patient with severe systemic symptoms (weight loss, malaise, and anorexia), eosinophilic oesophagitis, and raised inflammatory markers coinciding with the use of lisinopril. The onset of symptoms occurred after the administration of lisinopril and resolved shortly after cessation of the medication. Despite thorough investigation, no other cause of the systemic inflammation and anaemia of chronic disease was found. “Drug rash with eosinophilia and systemic symptoms” (DRESSs) syndrome describes a potentially serious multiorgan inflammatory response to certain classes of drugs; this includes the use of ACE inhibitors. Although this patient did not meet strict criteria for DRESSs, the subacute inflammatory syndrome with eosinophilic organ infiltration bears ... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5348499 Wed, 26 Oct 2011 19:24:29 +0100 5348499 http://www.medworm.com/index.php?rid=5348498&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcrim%2F2011%2F351267%2F We report a case of complete hydatidiform mole in a 54-year-old patient referred to Gynecology department of General Hospital of Athens “Laiko”, with history of previous molar pregnancy at the age of thirty-six. Our purpose was to indicate the advanced maternal age beside the long recurrence distance of the disease, which was eighteen years after the first molar pregnancy. Our diagnostic approach was through measurement of serum beta-human chorionic gonadotropin (β-HCG) and pelvic ultrasound evaluation, and the chosen therapeutic approach was abdominal hysterectomy and bilateral salpingoophorectomy. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5348498 Wed, 26 Oct 2011 19:24:29 +0100 5348498 http://www.medworm.com/index.php?rid=5348497&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Faess%2F2011%2F541592%2F Despite the overwhelming importance of earthworm activity in the soil system, there are a limited number of studies that have examined the impact resulting from biochar addition to soil. Biochar is part of the black carbon continuum of chemo-thermal converted biomass. This review summarizes existing data pertaining to earthworms where biochar and other black carbon substances, including slash-and-burn charcoals and wood ash, have been applied. After analyzing existing studies on black carbon, we identified that these additions have a range from short-term negative impacts to long-term null effects on earthworm population density and total biomass. Documented cases of mortality were found with certain biochar-soil combinations; the cause is not fully understood, but hypothesized to be relat... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5348497 Wed, 26 Oct 2011 19:24:29 +0100 5348497 http://www.medworm.com/index.php?rid=5348496&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcrim%2F2011%2F858241%2F We present a case and an ultrasound image of early cervical ectopic pregnancy with a history of two previous cesarean sections who was successfully treated with suction curettage. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5348496 Wed, 26 Oct 2011 19:24:29 +0100 5348496 http://www.medworm.com/index.php?rid=5348495&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Faaa%2F2011%2F908491%2F We study the distribution eαx(♢+m2)kδ for m≥0, where (♢+m2)k is the diamond Klein-Gordon operator iterated k times, δ is the Dirac delta distribution, x=(x1,x2,…,xn) is a variable in ℝn, and α=(α1,α2,…,αn) is a constant. In particular, we study the application of eαx(♢+m2)kδ for solving the solution of some convolution equation. We find that the types of solution of such convolution equation, such as the ordinary function and the singular distribution, depend on the relationship between k and M. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5348495 Wed, 26 Oct 2011 19:24:29 +0100 5348495 http://www.medworm.com/index.php?rid=5348494&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcrim%2F2011%2F108709%2F Herein we report the diagnostic potential of cardiac computed tomography (cCT) to delineate the origin and course of an anomalous right coronary artery (RCA) originating from the midpart of the left anterior descended artery (LAD) in an adult with no other form of congenital heart disease. The patient was referred to our institution due to exertional dyspnea and suspected coronary artery disease. The patient underwent X-ray coronary angiography, and no high grade lesions were observed in the left coronary vessels. In the course of the mid-left-anterior-descending artery (LAD), an anomalous side branch coursing away from the left circumflex coronary artery (LCX) was observed, while a right coronary ostium could not be depicted. cCT confirmed the absence of a right coronary ostium, and the v... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5348494 Wed, 26 Oct 2011 19:24:29 +0100 5348494 http://www.medworm.com/index.php?rid=5348493&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fads%2F2011%2F425820%2F We propose a novel knowledge management system (KMS) for enterprises. Our system exploits two different approaches for knowledge representation and reasoning: a document-based approach based on data-driven creation of a semantic space and an ontology-based model. Furthermore, we provide an expert system capable of supporting the enterprise decisional processes and a semantic engine which performs intelligent search on the enterprise knowledge bases. The decision support process exploits the Bayesian networks model to improve business planning process when performed under uncertainty. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5348493 Wed, 26 Oct 2011 19:24:29 +0100 5348493 http://www.medworm.com/index.php?rid=5348492&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fijbm%2F2011%2F109638%2F In conclusion, the composite implant material can be applied with hASCs for tissue engineering but not be evaluated in vivo with sheep. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5348492 Wed, 26 Oct 2011 19:24:29 +0100 5348492 http://www.medworm.com/index.php?rid=5348491&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fjobes%2F2011%2F918402%2F Self-reported disability in performing daily life activities was assessed in adults with severe obesity (BMI ≥ 35 kg/m2) using the Health Assessment Questionnaire (HAQ). 262 participants were recruited into three BMI groups: Group I: 35–39.99 kg/m2; Group II: 40–44.99 kg/m2; Group III: ≥45.0 kg/m2. Progressively increasing HAQ scores were documented with higher BMI; Group I HAQ score: 0.125 (median) (range: 0–1.75); Group II HAQ score: 0.375 (0–2.5); Group III HAQ score: 0.75 (0–2.65) (Group III versus II P<0.001; Group III versus I P<0.001; Group II versus I P=0.004). HAQ score strongly correlated with BMI and age. Nearly three-fourths of the study participants reported some degree of di... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5348491 Wed, 26 Oct 2011 19:24:29 +0100 5348491 http://www.medworm.com/index.php?rid=5348490&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fjbb%2F2011%2F718710%2F Newcastle disease virus (NDV) is an avian virus that causes deadly infection to over 250 species of birds, including domestic and wild-type, thus resulting in substantial losses to the poultry industry worldwide. Many reports have demonstrated the oncolytic effect of NDV towards human tumor cells. The interesting aspect of NDV is its ability to selectively replicate in cancer cells. Some of the studies have undergone human clinical trials, and favorable results were obtained. Therefore, NDV strains can be the potential therapeutic agent in cancer therapy. However, investigation on the therapeutic perspectives of NDV, especially human immunological effects, is still ongoing. This paper provides an overview of the current studies on the cytotoxic and anticancer effect of NDV via direct oncol... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5348490 Wed, 26 Oct 2011 19:24:29 +0100 5348490 http://www.medworm.com/index.php?rid=5324431&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fijce%2F2011%2F970247%2F A reduced chemical kinetic model for Titan's atmosphere has been developed. This new model with 18 species and 28 reactions includes the mainfeatures of a more complete scheme, respecting the radiative fluxes. It has been verified against three key elements: a sensitivity analysis, the equilibrium chemical composition using shock tube simulations in CHEMKIN, and the results of computational fluid dynamics (CFDs) simulations. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5324431 Tue, 18 Oct 2011 09:14:08 +0100 5324431 http://www.medworm.com/index.php?rid=5324430&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcrim%2F2011%2F134801%2F We report a case of a 67-year-old woman who admitted with fever, myalgia, and altered status. After thorough investigation, a tumor of the jejunum was found. The patient underwent complete surgical removal of the tumor. A diagnosis of MFN (undifferentiated high-grade pleomorphic sarcoma) was made. The patient received adjuvant chemotherapy with Gemcitabine. Two years after the operation, the patient died due to recurrence of the disease. MFH of the small intestine is an extremely rare neoplasm with an aggressive biological behaviour. In this paper, pathogenesis, natural history, and treatment are reviewed. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5324430 Tue, 18 Oct 2011 09:14:08 +0100 5324430 http://www.medworm.com/index.php?rid=5315212&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbcri%2F2011%2F369484%2F This paper deals with the purification of four proteins from Euphorbia characias latex, a copper amine oxidase, a nucleotide pyrophosphatase/phosphodiesterase, a peroxidase, and a purple acid phosphatase. These proteins, very different in molecular weight, in primary structure, and in the catalyzed reaction, are purified using identical preliminary steps of purification and by chromatographic methods. In particular, the DEAE-cellulose chromatography is used as a useful purification step for all the four enzymes. The purification methods here reported allow to obtain a high purification of all the four proteins with a good yield. This paper will give some thorough suggestions for researchers busy in separation of macromolecules from different sources. (Source: Experimental Diabetes Research... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5315212 Sat, 15 Oct 2011 07:43:57 +0100 5315212 http://www.medworm.com/index.php?rid=5315211&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Faaa%2F2011%2F373910%2F We study the normality of families of holomorphic functions. We prove the following result. Let α(z),  ai(z),  i=1,2,…,p, be holomorphic functions and F a family of holomorphic functions in a domain D, P(z,w):=(w-a1(z))(w-a2(z))⋯(w-ap(z)),  p≥2. If Pw∘f(z) and Pw∘g(z) share α(z) IM for each pair f(z),  g(z)∈F and one of the following conditions holds: (1) P(z0,z)-α(z0) has at least two distinct zeros for any z0∈D; (2) there exists z0∈D such that P(z0,z)-α(z0) has only one distinct zero and α(z) is nonconstant. Assume that β0 is the zero of P(z0,z)-α(z0) and that the multiplicities l and k of zeros of f(z)-β0 ... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5315211 Sat, 15 Oct 2011 07:43:57 +0100 5315211 http://www.medworm.com/index.php?rid=5315210&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fijde%2F2011%2F793023%2F This paper is concerned with the existence and uniqueness of a mild solution of a semilinear fractional-order functional evolution differential equation with the infinite delay and impulsive effects. The existence and uniqueness of a mild solution is established using a solution operator and the classical fixed-point theorems. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5315210 Sat, 15 Oct 2011 07:43:57 +0100 5315210 http://www.medworm.com/index.php?rid=5297483&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fau%2F2011%2F813205%2F The aim was to retrospectively determine the real incidence of congenital penile curvature in various forms of hypospadias, in order to indicate intraoperative assessment and correction of curvature. We analyzed 842 patients with hypospadias who underwent surgery from 2003 to 2010, classified into two groups. First group was intraoperatively checked for curvature as a routine procedure, while a curvature in the second group was assessed mostly in severe hypospadias. Results are analyzed using Fisher's and chi-square tests. In total, 238 cases (28.3%) of associated curvature were confirmed. Curvature was significantly more frequent in the first group, regarding hypospadias in general (P<0.01), as well as distal (P<0.05) and midshaft forms (P<0.01). Penile curvat... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5297483 Sun, 09 Oct 2011 07:38:13 +0100 5297483 http://www.medworm.com/index.php?rid=5297482&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fcrim%2Fendocrinology%2F2011%2F584930%2F We describe a 13-year-old girl with chronic thyroiditis and RTH. This patient had increased plasma free T3, free T4 at the upper limits with unsuppressed TSH. She had peripheral manifestations of thyroid hormone excess, hypertension and growth acceleration. Anti-TPO antibodies were positive. Sequence analysis of the TRβ gene was performed and revealed a novel mutation I54V in exon 4. The same mutation was also found in the mother and two asymptomatic sisters. The clinical presentation of our patient is not habitual in RTH because growth retardation is frequently reported in this syndrome. The association between RTH and thyroiditis complicate the management of the hypothyroidism. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5297482 Sun, 09 Oct 2011 07:38:13 +0100 5297482 http://www.medworm.com/index.php?rid=5297481&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fjtd%2F2011%2F730960%2F The Group Contribution Equation of State (GC-EoS) was extended to represent high-pressure phase equilibria behavior of mixtures containing mono-, di-, triglycerides, and carbon dioxide (CO2). For this purpose, the alcohol-ester and the alcohol-triglyceride binary group interaction parameters were regressed in this work, using experimental phase equilibria data from the literature. The capability of the parameters obtained was assessed by applying the GC-EoS model to simulate the supercritical CO2 fractionation of a complex glyceride mixture, which was produced by the ethanolysis of sunflower oil. Experimental data was obtained in a countercurrent packed extraction column at pressures ranging from 16 to 25 MPa and temperatures from 313 to 368 K. The GC-EoS model was applied i... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=5297481 Sun, 09 Oct 2011 07:38:13 +0100 5297481 http://www.medworm.com/index.php?rid=4999744&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fjtran%2F2011%2F483728%2F Patients requiring liver transplantation (LT) frequently experience renal insufficiency (RI), which affects their survival. Although calcineurin inhibitor-sparing immunosuppressive regimens (CSRs) are well known to prevent RI, the immune state in recipients receiving CSR remains to be intensively investigated. Among 60 cases of living-donor LT at our institute, 68% of the patients had none to mild RI (non-RI group) and 32% of the patients had moderate to severe RI (RI group). The RI group received a CSR comprising reduced dose of tacrolimus, methylprednisolone, and mycophenolate mofetil, while the non-RI group received a regimen comprising conventional dose of tacrolimus and methylprednisolone. One year after LT, the mean estimated glomerular filtration rate (eGFR) in the RI group ... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4999744 Wed, 06 Jul 2011 15:09:32 +0100 4999744 http://www.medworm.com/index.php?rid=4999743&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fisrn%2Fgastroenterology%2F2011%2F756292%2F We discuss the diagnosis of and efficacy 5-amino-2-hydroxybenzoic acid (5-ASA), Saccharomyces boulardii, or magnesium in therapy of microscopic colitis with presence of foamy macrophages. A basis for diagnosis and inclusion to the analysed group was presence of characteristic foamy macrophages in histopathological examination of hematoxylin and eosin-stained specimens collected from the large intestine, reviewed under ×200 or ×320 magnification. No statistically significant improvement was found following the use of 5-amino-2-dihydroxybenzoic acid in therapy of the disease. The use of Saccharomyces boulardii was associated with statistically significant improvement in clinical, endoscopic, and histopathological condition. Use of magnesium caused a histological, st... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4999743 Wed, 06 Jul 2011 15:09:32 +0100 4999743 http://www.medworm.com/index.php?rid=4999742&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fisrn%2Fpharmaceutics%2F2011%2F860109%2F Polymeric delivery systems based on nanoparticles have emerged as a promising approach for peroral insulin delivery. The aim of the present study was to investigate the release of insulin nanoparticulate systems and ex vivo studies. The nanoparticles were prepared by the ion gelation method. Particle size distribution, zeta potential, and polydispersity index of the nanoparticles were determined. It was found that the nanoparticles carried positive charges and showed a size distribution in the range of 170–200 nm. The electrostatic interactions between the positively charged group of chitosan and negatively charged groups of Arabic gum play an important role in the association efficiency of insulin in nanoparticles. In vitro insulin release studies showed an initial burst f... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4999742 Wed, 06 Jul 2011 15:09:32 +0100 4999742 http://www.medworm.com/index.php?rid=4986763&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fisrn%2Fma%2F2011%2F183795%2Fabs%2F We study a class of linear matrix differential equations (regular case) of higher order whose coefficients are square constant matrices. By using matrix pencil theory and the Weierstrass canonical form of the pencil we obtain formulas for the solutions and we show that the solution is unique for consistent initial conditions and infinite for nonconsistent initial conditions. Moreover we provide some numerical examples. These kinds of systems are inherent in many physical and engineering phenomena. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4986763 Fri, 01 Jul 2011 17:47:51 +0100 4986763 http://www.medworm.com/index.php?rid=4986762&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcrig%2F2011%2F258978%2Fabs%2F Conclusions. These three cases further confirm the essential features of diabetes caused by INS mutations with proteotoxic effect. We conclude that patients with similar features must be investigated for mutations of INS gene. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4986762 Fri, 01 Jul 2011 17:47:51 +0100 4986762 http://www.medworm.com/index.php?rid=4986761&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fipid%2F2011%2F504280%2Fabs%2F The fungal pathogen Candida albicans is one of the leading causative agents of death in immunocompromised individuals. It harbors an arsenal of cell wall anchored factors that are implicated in virulence such as filamentation inducing factors, adhesins, lipases, proteases, and superoxide dismutases. Dse1 is a cell wall protein involved in cell wall metabolism. The purpose of this study is to characterize the role Dse1 plays in virulence. Dse1 appears to be an essential gene as no homozygous null mutant was possible. The heterozygote mutant exhibited increased susceptibility to calcofluor white, a cell wall disrupting agent, with a subsequent reduction in cell wall chitin content, decreased oxidative stress tolerance, a 30% reduction in biofilm formation, and a delay in adhesion that wa... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4986761 Fri, 01 Jul 2011 17:47:51 +0100 4986761 http://www.medworm.com/index.php?rid=4961876&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fecam%2F2011%2F497673%2F Nymphaea candida is traditional Uighur medicine that is commonly used to treat head pains, cough, hepatitis and hypertension in Xinjiang of China. In this article, the extract of N. candida was measured for antioxidant activity, using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals scavenging assay and reducing power determination, and compared with those of the positive controls of butylated hydroxytoluene (BHT) and gallic acid (GA). The active extract was further purified by liquid-liquid partition to afford four fractions, of which the ethyl acetate-soluble (EA) fraction (NCE) exhibited the strongest antioxidant capacity with IC50 value of 12.6 μg/mL for DPPH. Thirteen phenolic compounds were isolated from this fraction, and they all showed significant antioxidant activities in D... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4961876 Fri, 24 Jun 2011 14:03:30 +0100 4961876 http://www.medworm.com/index.php?rid=4961875&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fecam%2F2011%2F524349%2F Baccharis dracunculifolia DC (Asteraceae) is a Brazilian medicinal plant popularly used for its antiulcer and anti-inflammatory properties. This plant is the main botanical source of Brazilian green propolis, a natural product incorporated into food and beverages to improve health. The present study aimed to investigate the chemical profile and intestinal anti-inflammatory activity of B. dracunculifolia extract on experimental ulcerative colitis induced by trinitrobenzenosulfonic acid (TNBS). Colonic damage was evaluated macroscopically and biochemically through its evaluation of glutathione content and its myeloperoxidase (MPO) and alkaline phosphatase activities. Additional in vitro experiments were performed in order to test the antioxidant activity by inhibition of induced lipid peroxi... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4961875 Fri, 24 Jun 2011 14:03:30 +0100 4961875 http://www.medworm.com/index.php?rid=4961874&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fecam%2F2011%2F608921%2F In conclusion, the numbers of doctors who practice CAM therapies, possess CAM knowledge and desire to practice such therapies have increased over the last 6 years in Japan. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4961874 Fri, 24 Jun 2011 14:03:30 +0100 4961874 http://www.medworm.com/index.php?rid=4961873&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fecam%2F2011%2F697986%2F The objective of this study was to determine antioxidant and cytotoxic efficacies of methanolic and aqueous extracts of Rheum emodi Wall. ex Meissn. rhizome. 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radical scavenging activities, inhibitory effect on lipid peroxidation and Fe3+ reducing antioxidant property have been used to investigate antioxidant properties of the extracts. Cytotoxicity of the extracts was tested on MDA-MB-435S and Hep3B cell lines. Both extracts displayed extensive cytotoxicity to the tested cell lines. The extracts were studied for their ability to protect pBR322 DNA from damage by UV induced photolysis of H2O2. The aqueous extract, though inferior to methanolic extract in its antioxidant potential exhibited efficiency in DNA protection, while the methanolic e... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4961873 Fri, 24 Jun 2011 14:03:30 +0100 4961873 http://www.medworm.com/index.php?rid=4961872&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fecam%2F2011%2F738131%2F Mumijo is a widely used traditional medicine, especially in Russia, Altai Mountains, Mongolia, Iran Kasachstan and in Kirgistan. Mumijo preparations have been successfully used for the prevention and treatment of infectious diseases; they display immune-stimulating and antiallergic activity as well. In the present study, we investigate the chemical composition and the biomedical potential of a Mumijo(-related) product collected from the Antarctica. The yellow material originates from the snow petrels, Pagodroma nivea. Extensive purification and chemical analysis revealed that the fossil samples are a mixture of glycerol derivatives. In vitro experiments showed that the Mumijo extract caused in cortical neurons a strong neuroprotective effect against the apoptosis-inducing amyloid peptide f... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4961872 Fri, 24 Jun 2011 14:03:30 +0100 4961872 http://www.medworm.com/index.php?rid=4961871&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fecam%2F2011%2F761859%2F Advanced glycation end products (AGEs) have been implicated in the development of diabetic complications, including diabetic nephropathy. KIOM-79, an 80% ethanolic extract obtained from parched Puerariae Radix, gingered Magnolia Cortex, Glycyrrhiza Radix and Euphorbia Radix, was investigated for its effects on the development of renal disease in Zucker diabetic fatty rats, an animal model of type 2 diabetes. In vitro inhibitory effect of KIOM-79 on AGEs cross-linking was examined by enzyme-linked immunosorbent assay (ELISA). KIOM-79 (50 mg/kg/day) was given to Zucker diabetic fatty rats for 13 weeks. Body and kidney weight, blood glucose, glycated hemoglobin, urinary albumin and creatinine excretions were monitored. Kidney histopathology, collagen accumulation, fibrinogen and transfo... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4961871 Fri, 24 Jun 2011 14:03:30 +0100 4961871 http://www.medworm.com/index.php?rid=4961870&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fecam%2F2011%2F784826%2F This study was aimed at investigating the therapeutic potential of polar (methanolic and aqueous) and nonpolar (hexane and chloroform) crude extracts of the whole plant. Several parameters including free-radical (DPPH•, ABTS•+, H2O2 and •OH) scavenging, reducing power, protection of DNA against oxidative damage, cytotoxicity, inhibition of oxidative hemolysis in erythrocytes, total phenolic content and inhibition of lipid peroxidation were examined. All the free-radical generating assay models demonstrated positive scavenging efficiency with differential but considerable magnitudes for the four extracts. However, only the hexane extract showed significant H2O2 scavenging effect. Lipid peroxidation was estimated by thiobarbituric acid-malondialdehyde (MDA) reaction, and... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4961870 Fri, 24 Jun 2011 14:03:30 +0100 4961870 http://www.medworm.com/index.php?rid=4961869&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fecam%2F2011%2F790784%2F Circulating adhesion molecules (CAMs), surface proteins expressed in the vascular endothelium, have emerged as risk factors for cardiovascular disease (CVD). CAMs are involved in intercellular communication that are believed to play a role in atherosclerosis. A Chinese medicine, the “Dantonic Pill” (DP) (also known as the “Cardiotonic Pill”), containing three Chinese herbal material medica, Radix Salviae Miltiorrhizae, Radix Notoginseng and Borneolum Syntheticum, has been used in China for the prevention and management of CVD. Previous laboratory and animal studies have suggested that this preparation reduces both atherogenesis and adhesion molecule expression. A parallel double blind randomized placebo-controlled study was conducted to assess the effects of the... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4961869 Fri, 24 Jun 2011 14:03:30 +0100 4961869 http://www.medworm.com/index.php?rid=4961868&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fecam%2F2011%2F816156%2F Young shoots of Rubus species have been used for healing of wounds, infected insect bites and pimples in folk medicine for ages. In order to evaluate the wound healing activity of Rubus sanctus, four different extracts were prepared from the whole aerial parts of the plant by using n-hexane, chloroform, ethyl acetate and methanol, respectively. Incision wound healing model by using tensiometer on rats and excision model on mice were employed to assess the activity. Remarkable wound healing activity was observed with the ointment formulation of the methanol extract at 1% concentration on the mentioned models. The results of histopathological examination also supported the outcome of both incision and excision wound models. The wound healing effect was comparatively evaluated with a referenc... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4961868 Fri, 24 Jun 2011 14:03:30 +0100 4961868 http://www.medworm.com/index.php?rid=4961867&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fecam%2F2011%2F840516%2F Radix Pseudostellariae is used as a tonic drug in traditional Chinese medicine with immunomodulating and anti-fatigue activities, and the polysaccharide is considered as the main active component. The purpose of this study is to examine the effect of the polysaccharide isolated from Radix Pseudostellariae (PRP) on mouse chronic fatigue syndrome (CFS) induced by intraperitoneal injection of polyriboinosinic:polyribocytidylic acid (poly I:C), a double-stranded synthetic RNA. It has shown that the fatigue symptom of mice lasted at least 1 week as evaluated by forced swimming time. PRP (100, 200, 400 mg kg−1), orally administered 3 days before poly I:C injection, showed dose-dependent anti-fatigue effects. In addition, poly I:C led to evident alternations in neuroendocrine... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4961867 Fri, 24 Jun 2011 14:03:30 +0100 4961867 http://www.medworm.com/index.php?rid=4961866&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fecam%2F2011%2F974728%2F In conclusion, we propose that HMC05 may be a safe and potent herbal formula against vascular inflammation, and its action may be attributable to the inhibition of ROS- and NF-κB-dependent expression of adhesion molecules and chemokines. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4961866 Fri, 24 Jun 2011 14:03:30 +0100 4961866 http://www.medworm.com/index.php?rid=4961865&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fecam%2F2011%2F980760%2F This study shows that pellitorine and sarmentine have good oral bioavailability while sarmentosine is not absorbed from the gastrointestinal tract. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4961865 Fri, 24 Jun 2011 14:03:30 +0100 4961865 http://www.medworm.com/index.php?rid=4961864&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fecam%2F2011%2F858246%2F This project aims to assess the utility of bibliographic databases beyond the three major ones (MEDLINE, EMBASE and Cochrane CENTRAL) for finding controlled trials of complementary and alternative medicine (CAM). Fifteen databases were searched to identify controlled clinical trials (CCTs) of CAM not also indexed in MEDLINE. Searches were conducted in May 2006 using the revised Cochrane highly sensitive search strategy (HSSS) and the PubMed CAM Subset. Yield of CAM trials per 100 records was determined, and databases were compared over a standardized period (2005). The Acudoc2 RCT, Acubriefs, Index to Chiropractic Literature (ICL) and Hom-Inform databases had the highest concentrations of non-MEDLINE records, with more than 100 non-MEDLINE records per 500. Other productive databases had ra... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4961864 Fri, 24 Jun 2011 14:03:30 +0100 4961864 http://www.medworm.com/index.php?rid=4961863&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fecam%2F2011%2F954140%2F The budding yeast Saccharomyces cerevisiae is a valuable system to study cell-cycle regulation, which is defective in cancer cells. Due to the highly conserved nature of the cell-cycle machinery between yeast and humans, yeast studies are directly relevant to anticancer-drug discovery. The budding yeast is also an excellent model system for identifying and studying antifungal compounds because of the functional conservation of fungal genes. Moreover, yeast studies have also contributed greatly to our understanding of the biological targets and modes of action of bioactive compounds. Understanding the mechanism of action of clinically relevant compounds is essential for the design of improved second-generation molecules. Here we describe our methodology for screening a library of plant-deri... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4961863 Fri, 24 Jun 2011 14:03:30 +0100 4961863 http://www.medworm.com/index.php?rid=4961862&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fecam%2F2011%2F464289%2F Baccharis dracunculifolia is the source of Brazilian green propolis (BGP). Considering the broad spectrum of biological activities attributed to green proplis, B. dracunculifolia has a great potential for the development of new cosmetic and pharmaceutical products. In this work, the cultivation of 10 different populations of native B. dracunculifolia had been undertaken aiming to determine the role of seasonality on its phenolic compounds. For this purpose, fruits of this plant were collected from populations of 10 different regions, and 100 individuals of each population were cultivated in an experimental area of 1800 m2. With respect to cultivation, the yields of dry plant, essential oil and crude extract were measured monthly resulting in mean values of 399 ± 80 g, 0.6 ± 0.1&#... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4961862 Fri, 24 Jun 2011 14:03:30 +0100 4961862 http://www.medworm.com/index.php?rid=4954959&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fidog%2F2011%2F494769%2F Conclusions. At study sites, presumptive treatment for gonorrhea, chlamydia, and syphilis screening should continue. Presumptive treatment for trichomoniasis should be considered. Consistent condom use and partner treatment need to be reemphasized. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4954959 Wed, 22 Jun 2011 17:13:18 +0100 4954959 http://www.medworm.com/index.php?rid=4954958&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fjbb%2F2011%2F670589%2F We report here an in situ atomic force microscopic study describing the effect of indolicidin on an artificial supported planar bilayer membrane of dipalmitoyl phosphatidylcholine (DPPC) and on purple membrane of Halobacterium salinarum. Concentration dependent interaction of the peptide and membranes was found in case of DPPC resulting the destruction of the membrane. Purple membrane was much more resistant against indolicidin, probably due to its high protein content. Indolicidin preferred the border of membrane disks, where the lipids are more accessible. These data suggest that the atomic force microscope is a powerful tool in the study of indolicidin-membrane interaction. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4954958 Wed, 22 Jun 2011 17:13:18 +0100 4954958 http://www.medworm.com/index.php?rid=4954957&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fijmst%2F2011%2F687548%2F Prepared apple (Red Gala) cylinders were subjected to microwave-osmotic dehydration treatment under continuous flow medium spray (MWODS) conditions and then air-dried to a final 20% moisture content. The dried samples were evaluated for color and textural properties, and rehydration capacity. The MWODS pretreatments were based on a central composite rotatable design and a response surface methodology using five levels of sucrose concentration, temperature, and contact time at a constant flow rate of 2800 mL/min. The air-drying was carried out at 60°C, 15±1% relative humidity, and 0.64±0.02 m/s air velocity. The results were compared to untreated air-dried (AD) (worst-case scenario) and freeze-dried (FD) (best-case scenario) apples without the MWOD... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4954957 Wed, 22 Jun 2011 17:13:18 +0100 4954957 http://www.medworm.com/index.php?rid=4954956&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fogi%2F2011%2F746393%2F Conclusion. Obesity does not appear to influence the rate of bladder injury or urinary retention following TVT procedure. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4954956 Wed, 22 Jun 2011 17:13:18 +0100 4954956 http://www.medworm.com/index.php?rid=4954955&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fafs%2F2011%2F943161%2F Several authors have proposed different methods to find the solution of fully fuzzy linear systems (FFLSs) that is, fuzzy linear system with fuzzy coefficients involving fuzzy variables. But all the existing methods are based on the assumption that all the fuzzy coefficients and the fuzzy variables are nonnegative fuzzy numbers. In this paper a new method is proposed to solve an FFLS with arbitrary coefficients and arbitrary solution vector, that is, there is no restriction on the elements that have been used in the FFLS. The primary objective of this paper is thus to introduce the concept and a computational method for solving FFLS with no non negative constraint on the parameters. The method incorporates the principles of linear programming in solving an FFLS with arbitrary coefficients ... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4954955 Wed, 22 Jun 2011 17:13:18 +0100 4954955 http://www.medworm.com/index.php?rid=4946825&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fpsyche%2F2011%2F431874%2Fabs%2F About 953000 individuals of the cosmopolitan parasitoid, Coccophagus scutellaris (Dalman) (Hymenoptera: Aphelinidae), were released and evaluated during 2009-2010 for the control of the following soft scale insects (Hemiptera: Coccidae) infesting the following economic crops in Egypt: Ceroplastes rusci on citrus in Beni Seuf, Ceroplastes floridensis Comstock on citrus in Gharbiya, Coccus hesperidum L. on guava in Giza, Pulvinaria floccifera (Westwood) on mango in Sharqiya, Pulvinaria psidii Maskell on mango in Ismailia, Saissetia coffeae (Walker) on olive in Marsa Matruh, and Saissetia oleae (Oliver) on olive in the Northern Coast. The population of C. scutellaris showed a significant correlation with the build up of the population of the soft scale insects population in all of the release... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4946825 Mon, 20 Jun 2011 17:26:38 +0100 4946825 http://www.medworm.com/index.php?rid=4710642&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fjm%2F2011%2F436704%2F This paper deals with theoretical approach to surface tension of molten silicon and germanium, and contributes to this field, which is very important. A theoretical calculation for determining the surface tension of high-temperature semiconductor melts, such as molten silicon and germanium, in the temperature range 1687–1825 K and 1211–1400 K, respectively, is described. The calculated temperature-dependence surface tension data for both Si and Ge are expressed as γ=876-0.32  (T-Tm) and γ=571-0.074  (T-Tm) (mJ m−2), respectively. These values are in consistence with the reported experimental data (720–875 for Si and 560–632 mJ m−2 for Ge). The calculated surface tension for... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4710642 Thu, 14 Apr 2011 17:10:52 +0100 4710642 http://www.medworm.com/index.php?rid=4710641&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Farp%2F2011%2F458920%2F Monitored anesthesia care (MAC) is a safe, effective, and appropriate form of anesthesia for many minor surgical procedures. The proliferation of outpatient procedures has heightened interest in MAC sedation agents. Among the most commonly used MAC sedation agents today are benzodiazepines, including midazolam, and propofol. Recently approved in the United States is fospropofol, a prodrug of propofol which hydrolyzes in the body by alkaline phosphatase to liberate propofol. Propofol liberated from fospropofol has unique pharmacological properties, but recently retracted pharmacokinetic (PK) and pharmacodynamic (PD) evaluations make it difficult to formulate clear conclusions with respect to fospropofol's PK/PD properties. In safety and efficacy clinical studies, fospropofol demonstrate... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4710641 Thu, 14 Apr 2011 17:10:52 +0100 4710641 http://www.medworm.com/index.php?rid=4710640&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fisrn%2Fme%2F2011%2F657819%2F In this study, the effects of V-notch's opening angle on stress intensity factor and on T-stress of the crack have been investigated in detail. Our calculation has been performed in a number of opening angles and various crack lengths in mode I loading using photoelasticity method. We show that as opening angle grows at constant crack's length, SIF and T-stress decrease. Furthermore, as the crack's length increases, the V-notch effect diminishes and the crack behavior can be considered as a single-edge crack specimen. Finally, the obtained results were found to be in good agreement with outcome of numerical finite element analysis. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4710640 Thu, 14 Apr 2011 17:10:52 +0100 4710640 http://www.medworm.com/index.php?rid=4710639&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fijol%2F2011%2F890380%2F Conclusion. Massive hemorrhage in patients after tracheostomy is likely due to TIF. Ultrasound scanning before PDT and careful periodical followup of the trachea are required. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4710639 Thu, 14 Apr 2011 17:10:52 +0100 4710639 http://www.medworm.com/index.php?rid=4627933&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fmpe%2F2011%2F253523%2Fabs%2F We investigate the fluctuation behaviors of financial stock markets by Zipf analysis. In the present paper, the empirical research is made to describe ensembles and specifics of stock price returns for global stock indices, and the corresponding Zipf distributions are given. First we study the fluctuation behavior of global stock markets by (m,k)-Zipf method. Then we consider a dynamic stock price model, and we analyze the absolute frequencies and the relative frequencies for this financial model. Further, the Zipf distributions of returns for SSE Composite Index are studied for different time scales. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4627933 Thu, 24 Mar 2011 17:01:04 +0100 4627933 http://www.medworm.com/index.php?rid=4484738&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fedr%2F2010%2F686734.html In conclusion, long-term diabetes elicits changes in the subtype of the 5-HT receptor involved in modulation of vagally induced bradycardia. Activation of the 5-HT 1A receptors induces enhancement, whereas attenuation is due to 5-HT7 receptor activation. This 5-HT dual effect occurs at pre- and postjunctional levels. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4484738 Thu, 17 Feb 2011 17:03:35 +0100 4484738 http://www.medworm.com/index.php?rid=4446934&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fedr%2F2011%2F171376.html At the beginning of the third week of pregnancy, mouse fetuses with targeted disruption of their paternally-transmitted insulin-like growth factor 2 gene placental-specific transcripts have growth-restricted placentas but normal body weights due to upregulated placental nutrient transport. We assessed whether increased placental glucose transport rates were associated with raised maternal glucose concentrations by performing intraperitoneal glucose tolerance tests (ipGTT) in pregnant mice carrying knockout pups and comparing them with mice carrying genotype-matched phenotypically wild type pups. Mean ± SD body weights of affected pups were 95 ± 8% of control values at e16 and 73 ± 7% at e18. There were no differences in areas under the maternal ipGTT curves at ... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4446934 Tue, 08 Feb 2011 16:45:15 +0100 4446934 http://www.medworm.com/index.php?rid=4401247&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fedr%2F2011%2F692536.html In conclusion, myocyte expression of PPARδ and the adiponectin receptors are highly coordinated, and this might be of relevance for human lipid metabolism in vivo. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4401247 Thu, 27 Jan 2011 15:50:46 +0100 4401247 http://www.medworm.com/index.php?rid=4390414&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fedr%2F2011%2F173647.html Knowing that maternal diabetes is related to hyperglycemia and fetal hyperinsulinemia, which affect the lipid metabolism, the aim of this study was to evaluate the effects of Malpighia emarginata (acerola) juice on the glycemic and lipid profile of offspring of diabetic and nondiabetic Wistar rats. The adult offspring of non-diabetic dams and of dams with severe streptozotocin-induced diabetes were divided into groups: G1, offspring (of control dams) treated with water, G2, offspring (of diabetic dams) treated with water, G3, male offspring (of control dams) treated with acerola juice, and G4, male offspring (of diabetic dams) treated with acerola juice. The offspring of diabetic dams treated with acerola juice showed significantly decreased levels of glucose, cholesterol, triglycerides, a... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4390414 Mon, 24 Jan 2011 18:07:52 +0100 4390414 http://www.medworm.com/index.php?rid=4373752&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fedr%2F2010%2F476969.html In the past, the genetically diabetic-obese diabetes/diabetes (db/db) and obese/obese (ob/ob) mouse strains were used to investigate mechanisms of diabetes-impaired wound healing. Here we determined patterns of skin repair in genetically normal C57Bl/6J mice that were fed using a high fat diet (HFD) to induce a diabetes-obesity syndrome. Wound closure was markedly delayed in HFD-fed mice compared to mice which had received a standard chow diet (CD). Impaired wound tissue of HFD mice showed a marked prolongation of wound inflammation. Expression of vascular endothelial growth factor (VEGF) was delayed and associated with the disturbed formation of wound margin epithelia and an impaired angiogenesis in the reduced granulation tissue. Normal wound contraction was retarded and disordered. Woun... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4373752 Thu, 20 Jan 2011 15:44:03 +0100 4373752 http://www.medworm.com/index.php?rid=4356596&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fedr%2F2010%2F876701.html Diabetes ultimately results from an inadequate number of functional beta cells in the islets of Langerhans. Enhancing proliferation of functional endogenous beta cells to treat diabetes remains underexplored. Here, we report that excision of the Men1 gene, whose loss-of-function mutation leads to inherited multiple endocrine neoplasia type 1 (MEN1), rendered resistant to streptozotocin-induced hyperglycemia in a tamoxifen-inducible and temporally controlled Men1 excision mouse model as well as in a tissue-specific Men1 excision mouse model. Men1 excision prevented mice from streptozotocin-induced hyperglycemia mainly through increasing the number of functional beta cells. BrdU incorporation by beta cells, islet size, and circulating insulin levels were significantly increased in Men1-excis... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4356596 Mon, 17 Jan 2011 19:04:52 +0100 4356596 http://www.medworm.com/index.php?rid=4310623&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fedr%2F2010%2F974681.html Conclusions. The most predictive PBMC profile for renal disease associated with T2DM was an increase in the cell surface expression of AGE-R1, in the context of a decrease in membranous RAGE expression in humans, which warrants further investigation as a biomarker for progressive DN in larger patient cohorts. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4310623 Wed, 05 Jan 2011 17:50:20 +0100 4310623 http://www.medworm.com/index.php?rid=4296284&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fedr%2F2010%2F213176.html Organic nitrates represent a class of drugs which are clinically used for treatment of ischemic symptoms of angina as well as for congestive heart failure based on the idea to overcome the impaired NO bioavailability by “NO” replacement therapy. The present paper is focused on parallels between diabetes mellitus and nitrate tolerance, and aims to discuss the mechanisms underlying nitrate resistance in the setting of diabetes. Since oxidative stress was identified as an important factor in the development of tolerance to organic nitrates, but also represents a hallmark of diabetic complications, this may represent a common principle for both disorders where therapeutic intervention should start. This paper examines the evidence supporting the hypothesis that pentaerithrityl ... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4296284 Thu, 30 Dec 2010 00:22:59 +0100 4296284 http://www.medworm.com/index.php?rid=4296283&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fedr%2F2010%2F289614.html This study was to create a long-term rabbit model of diabetes mellitus for medical studies of up to one year or longer and to evaluate the effects of chronic hyperglycemia on damage of major organs. A single dose of alloxan monohydrate (100 mg/kg) was given intravenously to 20 young New Zealand White rabbits. Another 12 age-matched normal rabbits were used as controls. Hyperglycemia developed within 48 hours after treatment with alloxan. Insulin was given daily after diabetes developed. All animals gained some body weight, but the gain was much less than the age-matched nondiabetic rabbits. Hyperlipidemia, higher blood urea nitrogen and creatinine were found in the diabetic animals. Histologically, the pancreas showed marked beta cell damage. The kidneys showed significantly thicken... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4296283 Thu, 30 Dec 2010 00:22:59 +0100 4296283 http://www.medworm.com/index.php?rid=4296282&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fedr%2F2010%2F828531.html This study was designed to investigate the effect of fenofibrate, a PPAR-α activator, on the endothelial dysfunction, oxidative stress, and inflammation in streptozotocin diabetic rats. Diabetic rats received fenofibrate (150 mg kg−1 day−1) for 4 weeks. Fenofibrate treatment restored the impaired endothelium-dependent relaxation and increased basal nitric oxide availability in diabetic aorta, enhanced erythrocyte/liver superoxide dismutase and catalase levels, ameliorated the abnormal serum/aortic thiobarbituric acid reactive substances, and prevented the increased aortic myeloperoxidase without a significant change in serum total cholesterol and triglyceride levels. It did not affect the decreased total homocysteine level and the increased tumor necrosis factor-... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4296282 Thu, 30 Dec 2010 00:22:59 +0100 4296282 http://www.medworm.com/index.php?rid=4141255&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fedr%2F2010%2F761715.html Conclusions. The effect of elevated CRP on diabetes defined by the glucose criterion was mediated through obesity, but elevated GGT was an independent risk factor for diabetes in this Chinese population. None of the two was, however, associated with the elevated HbA1c concentrations. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4141255 Mon, 08 Nov 2010 02:13:47 +0100 4141255 http://www.medworm.com/index.php?rid=4127649&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fedr%2F2010%2F247861.html Endothelial dysfunction is characterized by reduced bioavailability of NO due to its inactivation to form peroxynitrite or reduced expression of eNOS. Here, we examine the causal role of peroxynitrite in mediating diabetes-induced endothelial dysfunction. Diabetes was induced by STZ-injection, and rats received the peroxynitrite decomposition catalyst (FeTTPs, 15 mg/Kg/day) for 4 weeks. Vasorelaxation to acetylcholine, oxidative-stress markers, RhoA activity, and eNOS expression were determined. Diabetic coronary arteries showed significant reduction in ACh-mediated maximal relaxation compared to controls. Diabetic vessels showed also significant increases in lipid-peroxides, nitrotyrosine, and active RhoA and 50% reduction in eNOS mRNA expression. Treatment of diabetic animals... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=4127649 Wed, 03 Nov 2010 20:24:23 +0100 4127649 http://www.medworm.com/index.php?rid=3859788&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fedr%2F2010%2F853176.html Conclusion. Insulin induces electrochemical changes in humans as in sheep via interaction with its receptor. This effect is abolished by glibenclamide. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=3859788 Fri, 13 Aug 2010 05:56:49 +0100 3859788 http://www.medworm.com/index.php?rid=3836096&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fedr%2F2010%2F714108.html Iron is an essential ion for life, playing a central role in many metabolic processes. The most important property of free iron is its capacity to be reversibly oxidized and reduced, but at same time this make it highly pro-oxidant molecule. In this regard, iron is able to generate powerful reactive oxygen species (ROS). For this reason, careful control on iron availability is central to the maintenance of normal cell function in the retina. In the diabetic eye there is an impairment of iron homeostasis, thus leading to iron overload. The mechanisms involved in this process include: (1) Destruction of heme molecules induced by hyperglycemia (2) Intraretinal and vitreal hemorrhages (3) Overexpression of the renin-angiotensin system. The main consequences of iron overload are the following: ... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=3836096 Mon, 09 Aug 2010 09:28:53 +0100 3836096 http://www.medworm.com/index.php?rid=3679326&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fedr%2F2010%2F617052.html In this study we investigated 1) the mechanism by which glucose regulates TSP-1 levels and 2) the mechanism by which TS-1 enhances IGF-I signaling. The addition of TSP-1 to primary SMC was sufficient to enhance IGF-I responsiveness in normal glucose. Reducing TSP-1 protein levels inhibited IGF-I signaling in SMC maintained in high glucose. We determined that TSP-1 protected IAP/CD47 from cleavage and thereby facilitated its association with SHP substrate-1 (SHPS-1). We have shown previously that the hyperglycemia induced protection of IAP from cleavage is an important component of the ability of hyperglycemia to enhance IGF-I signaling. Furthermore we determined that TSP-1 also enhanced phosphorylation of the β3 subunit of the αVβ3 integrin, another molecular event tha... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=3679326 Mon, 21 Jun 2010 05:33:08 +0100 3679326 http://www.medworm.com/index.php?rid=3623071&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fedr%2F2010%2F173652.html To evaluate the performance of dried blood spots (DBSs) with subsequent analyses of glutamic acid decarboxylase (GADA) and islet antigen-2 (IA-2A) with the RSR-ELISAs, we selected 80 children newly diagnosed with type 1 diabetes and 120 healthy women. DBSs from patients and controls were used for RSR-ELISAs while patients samples were analysed also with in-house RIAs. The RSR-ELISA-GADA performed well with a specificity of 100%, albeit sensitivity (46%) was lower compared to in RIA (56%; P=.008). No prozone effect was observed after dilution of discrepant samples. RSR-ELISA-IA-2A achieved specificity of 69% and sensitivity was lower (59%) compared with RIA (66%; P<.001). Negative or low positive patients and control samples in the RSR-ELISA-IA-2A increased a... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=3623071 Thu, 03 Jun 2010 13:13:16 +0100 3623071 http://www.medworm.com/index.php?rid=3596964&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fedr%2F2010%2F178372.html Conclusions. Individualized treatment plans for insulin initiation and administration mode are critical in achieving target glycaemic levels. Progress in these fields is expected to facilitate and improve the quality of life of diabetic patients. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=3596964 Wed, 26 May 2010 13:10:47 +0100 3596964 http://www.medworm.com/index.php?rid=3596963&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fedr%2F2010%2F543926.html The present study was designed to evaluate the oxidative stress as well as the therapeutic effect of Agaricus blazei Muril (A. Blazei) in rats with streptozotocin-induced diabetes. We used 25 Wistar rats, and DM was induced by injecting streptozotocin (70 mg/Kg i.p.). Agaricus blazei Muril was administered daily starting 40 days after disease onset. A. Blazei was tested as an aqueous extract for its phytochemical composition, and its antioxidant activity in vitro was also evaluated. Lipoperoxidation (LPO), and superoxide dismutase (SOD), catalase, and glutathione peroxidase activities were measured in the pulmonary tissue, as well as the presence of inducible nitric oxide synthase (iNOS), through immunohistochemistry. An anatomopathologic study was also performed. Phytochemical scre... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=3596963 Wed, 26 May 2010 13:10:47 +0100 3596963 http://www.medworm.com/index.php?rid=3422262&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fedr%2F2009%2F384683.html Increased muscle loading results in the phosphorylation of the 70 kDa ribosomal S6 kinase (p70S6k), and this event is strongly correlated with the degree of muscle adaptation following resistance exercise. Whether insulin resistance or the comorbidities associated with this disorder may affect the ability of skeletal muscle to activate p70S6k signaling following an exercise stimulus remains unclear. Here, we compare the contraction-induced activation of p70S6k signaling in the plantaris muscles of lean and insulin resistant obese Zucker rats following a single bout of increased contractile loading. Compared to lean animals, the basal phosphorylation of p70S6k (Thr389; 37.2% and Thr421/Ser424; 101.4%), Akt (Thr308; 25.1%), and mTOR (Ser2448; 63.0%) was higher in obese... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=3422262 Wed, 31 Mar 2010 13:27:15 +0100 3422262 http://www.medworm.com/index.php?rid=3396672&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fedr%2F2010%2F176361.html We hypothesized that rho/rho kinase plays a role in sex differences in vascular dysfunction of diabetics. Contractions to serotonin were greater in isolated aortic rings from nondiabetic males versus females and increased further in streptozotocin-induced diabetic males but not females. The increased contractions to serotonin in males were reduced by inhibitors of rho kinase (fasudil, Y27632 and H1152) despite no change in expression of rhoA or rho kinase. Contractions to U46619 were not altered by fasudil or Y27632 or the presence of diabetes. In contrast to acute effects of fasudil, chronic treatment with fasudil increased contractions to serotonin in aorta from both non-diabetic and diabetic males. In summary, serotonin-induced contractions were increased in aorta from diabetic males bu... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=3396672 Wed, 24 Mar 2010 14:18:03 +0100 3396672 http://www.medworm.com/index.php?rid=3233196&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fedr%2F2009%2F431980.html In this study we explored the role of NEP in neuropathy related to either insulin-deficient diabetes or diet-induced obesity using NEP deficient (−/−) mice. Initial studies showed that streptozotocin, in the absence of subsequent hyperglycemia, did not induce nerve conduction slowing or paw thermal hypoalgesia. Glucose disposal was impaired in both C57Bl/6 and NEP −/− mice fed a high fat diet. Thermal hypoalgesia and nerve conduction slowing were present in both streptozotocin-diabetic and high fat fed C57Bl/6 mice but not in NEP −/− mice exposed to either streptozotocin-induced diabetes or a high fat diet. These studies suggest that streptozotocin does not induce neurotoxicity in mice and that NEP plays a role in regulating nerve function in... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=3233196 Wed, 03 Feb 2010 14:23:29 +0100 3233196 http://www.medworm.com/index.php?rid=3173540&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fedr%2F2009%2F827943.html This study explores whether cold exposure contributes to the development of DPN. Streptozotocin-induced diabetic rats and controls were exposed to a room temperature (23∘C) or cold environment (10∘C). H-reflex, tail and sciatic motor, and sensory nerve conduction studies were performed. Analyses of sural nerve, intraepidermal nerve fibers, and skin and nerve nitrotyrosine ELISAs were performed. Diabetic animals exposed to a cold environment had an increased H-reflex four weeks earlier than diabetic room temperature animals (P=.03). Cold-exposed diabetic animals also had greater reduction in motor conduction velocities at 20 weeks (P=.017), decreased skin nerve fiber density (P=.037), and increased skin nitrotyrosine levels (P=.047). Cold exposure appears to hasten the develop... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=3173540 Fri, 15 Jan 2010 14:11:02 +0100 3173540 http://www.medworm.com/index.php?rid=3143932&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fedr%2F2009%2F267107.html Increased responsiveness of vascular cells to the growth factor IGF-I has been implicated in complications associated with diabetes. Here we describe the development of an assay and screening of a library of compounds for their ability to accelerate cleavage of the transmembrane protein integrin-associated protein (IAP) thereby disrupting the association between IAP and SHPS-1 which we have shown as critical for the enhanced response of vascular cells to IGF-I. The cell-based ELISA utilizes an antibody that specifically detects cleaved, but not intact, IAP. Of the 1040 compounds tested, 14 were considered active by virtue of their ability to ... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=3143932 Wed, 06 Jan 2010 14:10:59 +0100 3143932 http://www.medworm.com/index.php?rid=3123802&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fedr%2F2009%2F278762.html To investigate the different effects between sulfonylurea (SU) and glinide drugs in insulin secretion, pancreatic β-cells were repeatedly stimulated with SU (glimepiride) or glinide (mitiglinide). Total internal reflection fluorescent (TIRF) microscopy revealed that secondary stimulation with glimepiride, but not glucose and mitiglinide, failed to evoke fusions of insulin granules although primary stimulation with glucose, glimepiride, and mitiglinide induced equivalent numbers of exocytotic responses. Glimepiride, but not glucose and mitiglinide, induced abnormally sustained [Ca2+]i elevations and reductions of docked insulin granules on the plasma membrane. Our data suggest that the effect of glinide on insulin secretory mechanisms is similar to that of glucose. (Source: Experimen... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=3123802 Mon, 28 Dec 2009 14:09:48 +0100 3123802 http://www.medworm.com/index.php?rid=3109260&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fedr%2F2009%2F605139.html The purpose of our study was to investigate whether the Trp64Arg polymorphism in β3-AR gene and the −3826A/G polymorphism in the UCP1 gene were associated with the reduction in energy expenditure and fat oxidation both in resting and aerobic exercise in Japanese. Eighty-six nonobese young healthy Japanese were recruited. Energy expenditure was measured using indirect calorimetry. The subjects performed an aerobic exercise program at 60% of their maximal heart rate for 30 minutes. The level of fat oxidation at rest and aerobic exercise of the male subjects with Trp/Arg of the β3-AR gene was significantly lower than that of the Trp/Trp genotype. No difference in FO0-30 was observed in the female subjects. There was no association between UCP-1 polymorphism and energy... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=3109260 Tue, 22 Dec 2009 14:10:21 +0100 3109260 http://www.medworm.com/index.php?rid=3027970&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fedr%2F2009%2F107496.html (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=3027970 Thu, 26 Nov 2009 14:16:27 +0100 3027970 http://www.medworm.com/index.php?rid=3017822&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fedr%2F2009%2F737686.html Sorbitol accumulation is postulated to play a role in skeletal muscle dysfunction associated with diabetes. The purpose of this study was to determine the effects of insulin and of endurance exercise on skeletal muscle sorbitol levels in streptozotocin-induced diabetic rats. Rats were assigned to one experimental group (control sedentary, control exercise, diabetic sedentary, diabetic exercise, diabetic sedentary no-insulin). Diabetic rats received daily subcutaneous insulin. The exercise-trained rats ran on a treadmill (1 hour, 5X/wk, for 12 weeks). Skeletal muscle sorbitol levels were the highest in the diabetic sedentary no-insulin group. ... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=3017822 Mon, 23 Nov 2009 14:05:41 +0100 3017822 http://www.medworm.com/index.php?rid=2956316&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fedr%2F2009%2F136501.html Conclusions. There is a high prevalence of metabolic syndrome in this urban population of the northern west of Iran. Focus of cardiovascular prevention should be undertaken in this area. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=2956316 Wed, 04 Nov 2009 14:17:38 +0100 2956316 http://www.medworm.com/index.php?rid=2936439&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fedr%2F2009%2F631026.html Type 1 diabetes is caused by autoimmune destruction of pancreatic beta cells, possibly virus initiated. Virus infection induces alpha-interferon (IFN-α), leading to upregulation of genes encoding double-stranded (ds) RNA-dependent antiviral enzymes 2′,5′-oligoadenylate synthetase (2′5′AS) and PKR (p68). To investigate whether beta cell specificity could be due to antiviral differences between beta and alpha cells, we treated beta and alpha TC3 cell lines with IFN-α and/or poly(I:C) (a synthetic dsRNA). Results showed that, following IFN-α stimulation, increases in 2′5′AS levels and activities were significantly higher in beta than alpha cells (P<.001), whereas increases in PKR level and activity were comparable in the tw... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=2936439 Thu, 29 Oct 2009 14:11:31 +0100 2936439 http://www.medworm.com/index.php?rid=2906272&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fedr%2F2009%2F363787.html Conclusion. Overt diabetes alters cyclosporine disposition by modulating its clearance. Abnormalities in the lipid profile, among other factors, may contribute to the accelerated metabolic degradation of cyclosporine under hyperglycemic conditions. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=2906272 Tue, 20 Oct 2009 13:11:20 +0100 2906272 http://www.medworm.com/index.php?rid=2881859&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fedr%2F2009%2F793281.html We investigated mechanisms underlying progressive axonal dysfunction and structural deficits in type 1 BB/Wor-rats from 1 week to 10 month diabetes duration. Motor and sensory conduction velocities were decreased after 4 and 6 weeks of diabetes and declined further over the remaining 9 months. Myelinated sural nerve fibers showed progressive deficits in fiber numbers and sizes. Structural deficits in unmyelinated axonal size were evident at 2 month and deficits in number were present at 4 mo. These changes were preceded by decreased availability of insulin, C-peptide and IGF-1 and decreased expression of neurofilaments and β-III-tubulin. Upregulation of phosphorylating stress kinases like Cdk5, p-GSK-3β, and p42/44 resulted in increa... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=2881859 Mon, 12 Oct 2009 13:07:07 +0100 2881859 http://www.medworm.com/index.php?rid=2848357&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fedr%2F2009%2F329632.html Autonomic and peripheral neuropathies are well-described complications in diabetes. Diabetes mellitus is also associated to central nervous system damage. This little-known complication is characterized by impairment of brain functions and electrophysiological changes associated with neurochemical and structural abnormalities. The purpose of this study was to investigate brain structural and ultrastructural changes in rats with streptozotocin-induced diabetes. Cerebral cortex, hypothalamus, and cerebellum were obtained from controls and 8 weeks diabetic rats. Light and electron microscope studies showed degenerative changes of neurons and glia, perivascular and mitochondrial swelling, disarrangement of myelin sheath, increased area of myelinated axons, presynaptic vesicle dispersion in swo... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=2848357 Thu, 01 Oct 2009 16:36:29 +0100 2848357 http://www.medworm.com/index.php?rid=2749066&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fedr%2F2009%2F291027.html In conclusion, the strong positive relation of PTHrP with glucose in the fasting state in patients with type 2 diabetes mellitus raises several questions for further experimentation concerning its exact role and physiological significance. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=2749066 Tue, 01 Sep 2009 12:05:20 +0100 2749066 http://www.medworm.com/index.php?rid=2710429&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fedr%2F2009%2F715057.html In this study, SDT fatty rats were subjected to pair-feeding with SDT-+/+ (SDT) rats from 6 to 22 weeks of age. The ratio of visceral fat weight to subcutaneous fat weight (V/S) decreased at 12 weeks of age in the pair-feeding rats. The intraperitoneal fat weight such as epididymal and retroperitoneal fat weight decreased, whereas mesenteric fat weight had no change. Cell size of the epididymal fat in the pair-feeding rats tended to decrease. Glucose oxidation level in epididymal fat in the pair-feeding rats at 12 weeks of age was recovered to a similar level with that in SDT rats. These results indicated that SDT fatty rat is a useful model to evaluate the functional or the morphological features in adipose tissue and develop a novel drug for antiobesity. (Source: Experimental Diabetes Re... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=2710429 Wed, 19 Aug 2009 10:22:15 +0100 2710429 http://www.medworm.com/index.php?rid=2574359&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fedr%2F2009%2F910783.html Peroxisome proliferator-activated receptor (PPARγ), a ligand-dependent transcription factor, negatively modulates high glucose effects. We postulated that rosiglitazone (RSG), an activator of PPARγ prevents the upregulation of vascular endothelial growth factor (VEGF) and collagen IV by mesangial cells exposed to high glucose. Primary cultured rat mesangial cells were growth-arrested in 5.6 mM (NG) or 25 mM D-glucose (HG) for up to 48 hours. In HG, PPARγ mRNA and protein were reduced within 3 h, and enhanced ROS generation, expression of p22phox, VEGF and collagen IV, and PKC-ζ membrane association were prevented by RSG. In NG, inhibition of PPARγ caused ROS generation and VEGF expression that were unchanged by RSG. Reduced AMP... Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=2574359 Tue, 07 Jul 2009 10:53:45 +0100 2574359 http://www.medworm.com/index.php?rid=2572256&cid=s_37026_15_f&fid=37026&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fedr%2F2009%2F429593.html Conclusion. Heterozygosity at SNP rs2267161 in the gene encoding the CST enzyme confers increased risk of T2D. Females with the CC allele showed lower insulin resistance. (Source: Experimental Diabetes Research) Experimental Diabetes Research journals http://www.medworm.com/rss/comments.php?id=2572256 Mon, 06 Jul 2009 10:51:56 +0100 2572256