MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Experimental and Clinical Endocrinology and Diabetes' source. Wed, 08 Feb 2012 15:08:57 +0100 http://www.medworm.com/index.php?rid=5582882&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1291178 Exp Clin Endocrinol Diabetes 2012; 120: 35-44DOI: 10.1055/s-0031-1291178We evaluated the factors associated with inpatient costs including total costs, pharmaceutical costs and laboratory costs for diabetes-related admissions.Using data for 960 adult patients admitted between May 2005 and April 2008 with a primary or secondary diagnosis of type 2 diabetes mellitus (DM) at Sir Run Run Shaw Hospital affiliated with Zhejiang University Medical School (SRRSH) in Hangzhou, China, we evaluate the association between patient characteristics and inpatient costs with multivariable regression analyses.Total inpatient costs were positively associated with age, higher UKPDS stroke risk score, and presence of any complication. A regression that included patient socioeconomic and clinical characteristic... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5582882 Wed, 11 Jan 2012 05:00:00 +0100 5582882 http://www.medworm.com/index.php?rid=5582886&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1299704 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1299704Epidemiological studies have found an increased risk for colon cancer and faster disease progression in patients with type 2 diabetes mellitus (T2DM). We aimed to determine whether patients with T2DM are diagnosed with more advanced stages of colorectal cancer, i. e., metastasized disease (UICC III and IV), at the time of diagnosis, since such a finding may have an impact on future guidelines for patients with T2DM.A cross-sectional analysis of colorectal cancer patients was performed. Stages at diagnosis in patients with (18.0%) or without (82%) T2DM were compared using logistic regression analysis to correct for confounders.Patients with T2DM were older, more obese, and more often male (each p<0.05). Unexpectedly, patients with ... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5582886 Mon, 09 Jan 2012 05:00:00 +0100 5582886 http://www.medworm.com/index.php?rid=5582885&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1295472 The objectives of this study were firstly to indicate and compare differences regarding appraisal of stress or active coping responses in urban African (n=88) and Caucasian (n=101) male teachers of South Africa, in accord with the prevalence of MetS indicators. And secondly to investigate the extent to which utilisation of active coping responses, together with MetS indicators, predict target organ damage, in these men. The Coping Strategy Indicator determined high and low active coping responses in male teachers from the Sympathetic Activity and Ambulatory Blood Pressure in Africans (SABPA) study. SABPA inclusion and exclusion criteria were used. Additionally, diabetic medication users (n=8), and participants with renal impairment (n=2) or HIV positive (n=13), were excluded. MetS indicato... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5582885 Mon, 09 Jan 2012 05:00:00 +0100 5582885 http://www.medworm.com/index.php?rid=5582884&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1298014 We examined 101 male and female subjects with diabetes. Axillary temperature was measured prior to and after all meals (3 meals per day) and self-recorded for 1 week. The averages were calculated. Positive postprandial thermoregulation (PPT) was defined as a pattern in which each of 3 average postprandial temperatures was higher than the corresponding 3 preprandial temperatures. Negative postprandial thermoregulation (NPT) was defined as the pattern except for PPT.A significant increase in postprandial temperature was observed. With the exception of high-density lipoprotein (HDL)-cholesterol levels, there were no relationships between the categorized postprandial thermoregulation and other factors, including age, sex, body mass index, thyroid function, HbA1c, diabetic complications, lipid ... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5582884 Mon, 09 Jan 2012 05:00:00 +0100 5582884 http://www.medworm.com/index.php?rid=5582883&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1298016 This study shows that the combined administration of vitamins B1 and B6 to diabetic nephropathy patients causes a decrease in DNA glycation in leukocytes. Importantly the administration of vitamin B6 alone did not have such an effect. To our knowledge, these are the first reported findings related to glycation of leukocyte nuclear DNA in diabetic nephropathy.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5582883 Mon, 09 Jan 2012 05:00:00 +0100 5582883 http://www.medworm.com/index.php?rid=5582881&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1298013 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1298013Lipin1, a lately indentified adipokine, may link obesity with insulin resistance and diabetes. The present study aimed to investigate the changes and significance of lipin1 expression and lipin1-AMPK signaling in diet-induced hepatic insulin resistance.24 4-week-old Male Wistar rats were randomly divided into 2 groups: (1) control group (CO), (2) high-fat diet group (HF). Insulin sensitivity was evaluated by hyperinsulinemic-euglycemic clamp technique. The mRNA levels of α1 and α2 subunit of AMPKα as well as Lipin1 were measured using Real-time RT-PCR. The activities of AMPKα and Akt were evaluated by detection of p-AMPKα (Thr-172) and p-Akt (ser473) by Western blot.After treatment of 4 months, HF group showed significantly increa... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5582881 Mon, 09 Jan 2012 05:00:00 +0100 5582881 http://www.medworm.com/index.php?rid=5582880&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1291298 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1291298The hepatocytes from the adult mice when stimulated by glucose had been reported to synthesize and secrete insulin. The feasibility of controlling hyperglycemia in alloxan induced diabetic mice through hepatic synthesis of insulin was studied.Insulin synthesis was determined by in vitro translation of mRNA and by immunohistochemistry of the hepatocytes and assayed by enzyme linked immunosorbent assay (ELISA). Dermcidin isoform 2 (dermcidin) was measured by ELISA. Nitric oxide was measured by methemoglobin method. Insulin synthesis was quantitated by immunoblot technique and the expression of proinsulin genes I and II in the hepatocytes was quantitated by cDNA synthesisIt was found that in contrast to normal hepatocytes, the hepatocytes... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5582880 Mon, 09 Jan 2012 05:00:00 +0100 5582880 http://www.medworm.com/index.php?rid=5525621&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1297967 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1297967Ectopic ACTH-syndrome is a rare cause of Cushing’s disease. Despite extensive diagnostic procedures the source of ACTH secretion often remains occult.This case describes a 45-year old woman with an ectopic Cushing’s syndrome. Extensive imaging procedures including CT scan of chest and abdomen, octreotide scan and MRI of the chest and pituitary did not reveal the source of ACTH secretion.In consideration of an occult source of ACTH secretion we started a therapeutic trial with cabergoline (0.5 mg/d), a dopamine receptor agonist, which has been shown to be effective in ectopic Cushing’s syndrome. 2 months after cabergoline treatment had been initiated, ACTH and cortisol levels normalized in association with significant improvemen... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5525621 Tue, 20 Dec 2011 05:00:00 +0100 5525621 http://www.medworm.com/index.php?rid=5525620&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1295473 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1295473The role of opioid μ-receptor activation in the improvement of overactive bladder (OAB) remains obscure. Thus, we used loperamide to activate opioid μ-receptors for urinary bladder relaxation and compared the differences between normal and diabetic rats. Urinary bladder strips were isolated from Wistar rats that did or did not receive streptozotocin (STZ) injection for analysis of isometric tension. Samples were contracted with either acetylcholine (ACh) or KCl, and decrease of muscle tone (relaxation) was characterized after treatment with loperamide. Specific antagonists were used for pretreatment to compare the changes in loperamide-induced relaxation. As compared with normal rats, loperamide produced a more marked relaxation in b... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5525620 Tue, 20 Dec 2011 05:00:00 +0100 5525620 http://www.medworm.com/index.php?rid=5525619&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1295403 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1295403To investigate the impact of variants of the FTO gene (rs1421085, rs17817449, rs9939609) in obese children before and after lifestyle intervention.Design: Longitudinal, clinical intervention study with an increase in physical activity, and nutritional recommendations based on the ‘Optimized Mixed Diet for German Children and Adolescents’ (Research Institute of Child Nutrition, Germany). Study population: 75 overweight children (40 male, mean BMI 30.4±5.5 kg/m2, mean age 12.6±2.6 years). Measurements: Genotyping by means of a TaqMan SNP genotyping assay. Lean and fat mass were determined by means of DXA.For the whole study population, the 6-month lifestyle intervention resulted in a significant improvement (before interventio... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5525619 Tue, 20 Dec 2011 05:00:00 +0100 5525619 http://www.medworm.com/index.php?rid=5525618&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1295423 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1295423To unravel the possible mechanism of acute posttraumatic insulin resistance in rats.Resection of small intestine was performed to establish the surgical trauma model. The blood glucose and serum insulin level were detected and the HOMA index was calculated. The Hyperinsulinemic-euglycemic clamp was performed to investigate the glucose disposal rate by peripheral tissue. The content and phosphorylation state of IRS-1, p85 of PI3-K and PKB/Akt in skeletal muscle were measured respectively. Finally, the [3H] labeled glucose uptake experiment was carried out.The blood glucose elevated significantly after resection of small intestine in rats. The level of serum insulin decreased during the first 30 min after operation but elevated in the ... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5525618 Tue, 20 Dec 2011 05:00:00 +0100 5525618 http://www.medworm.com/index.php?rid=5525617&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1287792 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1287792We are reporting a case of 68-year-old woman with insulinoma, after a non-successful tumor surgery and a long-term diazoxide treatment. She had a lot of hypoglycemia cases, and a weight gain of 50 kg. An abdominal CT scan demonstrated a tumor 28 mm in the diameter, in the head of the pancreas. The patient did not agree for the repeated insulinoma surgery. Furthermore, we found a lesion in the left adrenal gland (14 mm in the diameter) and in the right lung (8 mm in the diameter). Pheochromocytoma was diagnosed on the basis of hypertension, elevated levels of normetanephrine in the 24-h urine collection, and an elevated level of norepinephrine in a plasma sample. After the left adrenal gland removal we observed lower blood press... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5525617 Tue, 20 Dec 2011 05:00:00 +0100 5525617 http://www.medworm.com/index.php?rid=5525616&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1297968 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1297968Lipid-lowering medications could lead to a significant reduction in major cardiovascular events in patients with diabetes. However, there was still controversy regarding the use of statins in patients with diabetes for primary prevention. The meta-analysis was performed to evaluate the outcomes of statin-therapy in diabetic patients without established cardiovascular diseases.7 randomized controlled trials of statin- vs. control-therapy in patients with diabetes were included. A total number of 12 711 patients were involved. The outcomes of interest were major adverse cardiovascular and cerebrovascular events (MACCE), including myocardial infarction, stroke, all-cause mortality and coronary revascularization.A total of 1 376 MACCE ... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5525616 Tue, 20 Dec 2011 05:00:00 +0100 5525616 http://www.medworm.com/index.php?rid=5525615&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1297970 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1297970Recent data suggest that insulin-like growth factor (IGF)-1 resistance in neurons prolongs longevity. In C. elegans this effect is mediated via DAF-16 the ortholog of the mammalian FoxO transcription factors. 3 different FoxO transcription factors (FoxOs) are expressed in rodent CNS: FoxO1, FoxO3a and FoxO6.To define whether the different FoxOs are region-, sex- and age-specifically expressed, we analyzed FoxO mRNA levels in different brain regions from 6, 16, 60 and 100 weeks old mice using realtime-PCR. In addition, we fed mice a high fat diet (HFD) to experimentally induce obesity and diabetes and analyzed FoxO mRNA in the different brain regions.Interestingly, FoxO1 was predominantly expressed in the hippocampus whereas FoxO3a was ... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5525615 Tue, 20 Dec 2011 05:00:00 +0100 5525615 http://www.medworm.com/index.php?rid=5525614&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1297969 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1297969Epidemiologic studies have examined the possible associations between diabetes mellitus (DM) and gastric cancer (GC), but the results are inconclusive. We conducted a meta-analysis to assess the evidence regarding the associations between diabetes and incidences of, or mortality from, gastric cancer.PubMed, Embase and Web of Science were searched up to Oct 20, 2011. We identified studies that included effects estimates with 95% confidence intervals (CIs) of the associations between GC and diabetes. Summary RRs for the GC incidence and mortality were calculated using random-effects model; subgroup analyses were also performed. Heterogeneity among studies was examined using Q and I2 statistics.A total of 7 case-control and 18 cohort stud... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5525614 Tue, 20 Dec 2011 05:00:00 +0100 5525614 http://www.medworm.com/index.php?rid=5525613&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1297253 The objective of this paper is to study a benefit of additional LT3 in athyreotic patients who failed to normalize TSH on LT4 alone even with hyperthyroid serum T4 values.In a survey of 200 athyreotic patients treated between 2006 and 2009, about 7% failed to normalize serum TSH levels following treatment with LT4, though serum T4 values in the hyperthyroid range were achieved. These patients (characterized by serum T4≥160 nmol/L and TSH≥5.0 mIU/L), were additionally treated with 10 μg b. i. d LT3. LT3 and LT4 combination therapy resulted in decreased serum TSH levels into the normal range (12.8 vs. 1.22 mIU/L; p<0.01) and reduced LT4 dose (153.3 vs. 117.5 μg; p<0.01) required for normalization of serum T4 values (170.6 vs. 123.3 nmol/L; p<0.01). Serum T3 val... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5525613 Tue, 20 Dec 2011 05:00:00 +0100 5525613 http://www.medworm.com/index.php?rid=5388208&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1279705 Conclusion: Even if difference in the size of nodules between groups A and B does not reach statistical significance, the chronic intrathyroid lymphocytic infiltration of HT may decrease the tendency of the AFTNs to grow and diminish their degree of functioning.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5388208 Tue, 08 Nov 2011 05:00:00 +0100 5388208 http://www.medworm.com/index.php?rid=5388207&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1283122 Exp Clin Endocrinol Diabetes 2011; 119: 636-643DOI: 10.1055/s-0031-1283122Molecular mechanisms underlying pathophysiology of polycystic ovary syndrome (PCOS), especially those related to cortisol signaling, are poorly understood. We hypothesized that modulation of glucocorticoid receptor (GR) expression and function, may underlie possible PCOS-related impairment of feedback inhibition of hypothalamic-pituitary-adrenocortical (HPA) axis activity and thus contribute to increased adrenal androgen production in women with PCOS.24 normal-weight and 31 obese women with PCOS were compared to 25 normal-weight controls. Fasting blood samples were collected for measurements of serum concentrations of dehydroepiandrosterone sulfate, testosterone, sex hormone-binding globulin, insulin, basal cortisol ... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5388207 Tue, 08 Nov 2011 05:00:00 +0100 5388207 http://www.medworm.com/index.php?rid=5388206&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1286316 This study suggests that acute isolated hyperinsulinaemia increases visceral sensitivity, but does not influence the somatic sensory function. The lack of changes in the evoked brain potentials may indicate that hyperinsulinaemia affects the visceral sensory system at a peripheral level. Our result suggests distinct functions of insulin in the various parts of the nervous system, and yields further clues to the significance of insulin as a satiety signal.[...]© J. A. Barth Verlag in George Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5388206 Tue, 08 Nov 2011 05:00:00 +0100 5388206 http://www.medworm.com/index.php?rid=5388205&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280800 Exp Clin Endocrinol Diabetes 2011; 119: 591-598DOI: 10.1055/s-0031-1280800Diabetic patients suffer more frequently from depression. Aim was to evaluate sociodemographic parameters and co-morbidities and late complications as potential modifying factors in the occurrence of depression in diabetic individuals.We performed a systematic review, based on established meta-analyses and additional original publications in 2005–2009 in Medline and PsycINFO. We included articles focusing on longitudinal studies which evaluated the appearance of depression in diabetic and non diabetic individuals and further analyzed interactions or separate additional influences of potential modifying factors.8 eligible studies were identified. 6 studies were population based. Only 3 studies analyzed the interacti... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5388205 Tue, 08 Nov 2011 05:00:00 +0100 5388205 http://www.medworm.com/index.php?rid=5388204&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1291258 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1291258Angiopoietin-like protein 4 (Angptl4) is thought to cause an increase in serum triglyceride levels. In the present study, we elucidated Angptl4 expression in the mouse models of type 1 and type 2 diabetes mellitus, and investigated the possible mechanisms involved.Type 1 diabetes was induced in C57BL/6 J mice by treating them with streptozotocin (STZ). Type 2 diabetes was induced by feeding the mice a high-fat diet (HFD) for 18 weeks.The levels of Angptl4 mRNA expression in liver, white adipose tissue (WAT), and brown adipose tissue (BAT) were found to increase in the STZ diabetic mice relative to control mice. This effect was attenuated by insulin administration. In the HFD diabetic mice, the Angptl4 mRNA expression levels were incr... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5388204 Tue, 08 Nov 2011 05:00:00 +0100 5388204 http://www.medworm.com/index.php?rid=5388203&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1286295 Exp Clin Endocrinol Diabetes 2011; 119: 628-632DOI: 10.1055/s-0031-1286295Studies in adults identified the -803 G>A promoter polymorphism (rs3758539) in the RBP4 gene (RBP4) as a functional variant conferring an increased risk for obesity and type 2 diabetes.We genotyped this polymorphism in a cohort of 304 lean and 283 obese children to assess a potential association with early onset obesity and blood pressure and evaluated the effect of this SNP on metabolic parameters in a smaller subset.The allele frequency of -803 G>A was similar in obese compared to lean subjects (0.159 vs. 0.191, P=0.318). We did not detect an association of the variant with adiposity parameters nor with parameters of glucose and lipid metabolism or blood pressure in quantitative analyses.Our study reveale... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5388203 Tue, 08 Nov 2011 05:00:00 +0100 5388203 http://www.medworm.com/index.php?rid=5388202&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1287782 Exp Clin Endocrinol Diabetes 2011; 119: 613-617DOI: 10.1055/s-0031-1287782We evaluated how low-level (3 ppm) subchronic inorganic arsenic (iAs) exposure from prenatal developmental stages until adult life affects glucose homeostasis. Biochemical parameters of glucose and lipid metabolism, pancreatic insulin and glycosylated haemoglobin were determined in 4-month-old female offspring of adult Wistar rats. Pancreatic histology was also performed. Statistical comparisons between control and iAs-treated groups were performed by unpaired two-tailed Student’s t-test. Statistical significance was set at p<0.05. We found that iAs treatment resulted in an impaired glucose tolerance test, suggestive of impaired glucose metabolism. This group was found to have hyperglycaemia and high levels of... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5388202 Tue, 08 Nov 2011 05:00:00 +0100 5388202 http://www.medworm.com/index.php?rid=5388201&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280799 Exp Clin Endocrinol Diabetes 2011; 119: 618-620DOI: 10.1055/s-0031-1280799To evaluate the prevalence of pancreatic auto-antibodies (PAb) as well as its relationship with HLA DR B1 and PTPN22 polymorphisms in first degree relatives (FDR) of Brazilian patients with Type 1 diabetes (T1D) and multiethnic background.FDR of patients with T1D were interviewed and blood was sampled for PAb measurement, HLA DRB1 and PTPN22 genotyping. Genotyping was also performed in index cases.In FDR (n=78), 16.7% presented at least one PAb. These individuals had a higher prevalence of HLA DRB1* 03 than others (p=0.03), without differences in PTPN22 genotyping. While the genetic profile was similar in FDR with PAb and their index cases, those without PAb had a lower frequency of HLA DR B1 * 03 than their co... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5388201 Tue, 08 Nov 2011 05:00:00 +0100 5388201 http://www.medworm.com/index.php?rid=5388200&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280801 Exp Clin Endocrinol Diabetes 2011; 119: 599-603DOI: 10.1055/s-0031-1280801Various studies have shown that the relationship between waist circumference (WC) and abdominal obesity is age, gender as well as ethnicity-dependent. WC criteria for Sub Saharan Africans have not been defined by the International Diabetes Federation (IDF). The aim was to determine which WC cut off best predicted Metabolic Syndrome (MetS) in a group of urban African teachers (80 males and 93 females). We determined sphygmomanometer blood pressure, WC, glucose, high density lipoprotein cholesterol (HdL) and triglyceride (TRIG) values. The males′ MetS profile was less favourable as their glucose, TRIG and blood pressure levels were higher than the proposed cut off for MetS. The females could be classified as obese, b... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5388200 Tue, 08 Nov 2011 05:00:00 +0100 5388200 http://www.medworm.com/index.php?rid=5388199&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1291315 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1291315The clinical features of lipid infiltration in the parotid glands (LIPG) have not been studied. Monitoring of atomic-bomb survivors for late effects of radiation exposure has provided the opportunity to review the clinical findings of LIPG.A total of 992 atomic-bomb survivors in Nagasaki, Japan underwent lachrymal and salivary secretion tests and anthropometric, biochemical, and abdominal ultrasonographic examinations between 2002 and 2004. Among 465 subjects who had reduced tear and/or salivary excretion, 176 subjects took a salivary magnetic resonance imaging (MRI) examination.LIPG was detected in 53 of the 176 subjects who had salivary MRI. LIPG cases showed a preponderance of females and fatty liver compared with the subjects witho... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5388199 Tue, 08 Nov 2011 05:00:00 +0100 5388199 http://www.medworm.com/index.php?rid=5388198&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1287791 Exp Clin Endocrinol Diabetes 2011; 119: 649-655DOI: 10.1055/s-0031-1287791Evidence is emerging that aldosterone contributes to the development and progression of atherosclerosis and cardiovascular disease. Little is known, however, regarding an association between circulating aldosterone levels and soluble cellular adhesion molecules in humans.We investigated the relationship between plasma aldosterone concentration (PAC) and soluble cellular adhesion molecules in a large cohort of patients referred to coronary angiography. After exclusion of patients with ongoing mineralocorticoid receptor blocker use, oral contraceptive or hormone replacement therapy, 1 733 patients (mean age: 62.5±10.8 years; 26.4%% women; mean PAC: 101.5±93.5 pg/mL) remained eligible for analyses.Pearson correlat... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5388198 Tue, 08 Nov 2011 05:00:00 +0100 5388198 http://www.medworm.com/index.php?rid=5388197&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1291343 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1291343Polycystic ovary syndrome (PCOS) is a frequent heterogenic disorder with a familial background. Androgenic effects, determining the clinical features of the syndrome, are mediated by the androgen receptor (AR), whose activity is modulated by a genetic polymorphism. We investigated the role of the CAG repeat polymorphism of the androgen receptor in PCOS.In the infertility unit of a university clinic, 72 PCOS patients were compared with 179 ovulatory controls undergoing a standardized diagnostic work-up. The number of CAG repeats was determined by PCR, labelling with IR-800 and PAGE. X-chromosome inactivation was assessed by a methylation-sensitive assay.Compared to controls, PCOS patients displayed a shorter mean CAG repeat length, enco... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5388197 Tue, 08 Nov 2011 05:00:00 +0100 5388197 http://www.medworm.com/index.php?rid=5336770&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1286339 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1286339Nesfatin-1, which is derived from nucleobindin2 (NUCB2), has been recently identified as a novel satiety regulator. However, its pathophysiological role in humans remains unknown. The aim of the present study was to investigate plasma nesfatin-1 levels and the association between plasma nesfatin-1 levels and various metabolic parameters in humans.74 subjects with newly diagnosed type 2 diabetes mellitus (nT2DM), 73 subjects with impaired glucose tolerance (IGT) and 73 subjects with normal glucose tolerance (NGT) were enrolled in this study. Plasma nesfatin-1 levels were measured by a commercially available enzyme- linked immunosorbent assay.Plasma nesfatin-1 levels were elevated in subjects with both nT2DM and IGT compared to controls ... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5336770 Fri, 21 Oct 2011 04:00:00 +0100 5336770 http://www.medworm.com/index.php?rid=5336769&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1287790 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1287790Carney complex (CNC) is an autosomal dominant hereditary or sporadic multiple neoplastic syndrome that shows variable clinical symptoms. Generally, CNC appears as skin pigmentation, cardiac or cutaneous myxomas, and multiple endocrine tumours. We performed an extensive evaluation of 9 individuals within 1 family in whom CNC was suspected. Among them, 5 had CNC with various clinical manifestations. We also performed mutational analysis of suspected genes in these patients. Although all patients were members of the same family, variable CNC-related manifestations were observed in each patient. An analysis showed a novel deletion mutation (c.537delA) in exon 6 of the PRKAR1A gene in the patients. Based on our results, the patients were de... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5336769 Fri, 21 Oct 2011 04:00:00 +0100 5336769 http://www.medworm.com/index.php?rid=5336768&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1291248 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1291248Diabetic neuropathy is one of the most severe complications of diabetes, affecting approximately one-third of diabetic patients. We investigated the potential neuroprotective effect of Actovegin®, a deproteinized hemoderivative of calf blood, in an animal model of diabetic neuropathy.A single intravenous injection of streptozotocin (STZ, 55 mg/kg) was used to induce experimental diabetes in male Sprague-Dawley rats. Actovegin® (200 or 600 mg/kg) was administered intraperitoneally from day 11 to day 40 post-STZ exposure. N-acetylcysteine (NAC) was used as a positive control and was added to drinking water (0.2 g/l) from day 2 until day 40. Measurements to assess efficacy included sensory nerve conduction velocity (SNCV), intraep... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5336768 Fri, 21 Oct 2011 04:00:00 +0100 5336768 http://www.medworm.com/index.php?rid=5336766&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1287789 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1287789Steroid 21-hydroxylase deficiency is caused by inactivating mutations in the CYP21A2 gene. This paper reports on the mutation spectrum and the genotype-phenotype correlation of 21-hydroxylase deficiency. 72 unrelated patients with congenital adrenal hyperplasia (CAH) were included. Molecular analysis of CYP21A2 was performed, via the multiplex ligation-dependent probe amplification (MLPA) analysis and sequence-specific differenzial PCR amplification of the CYP21A2 and CYP21A1P genes, using 4 pair-wise sequence-specific primers, followed by sequencing of the entire CYP21A2 gene. Large gene deletions were identified in 45 (31.3%) of the 144 unrelated CAH alleles, whereas the most frequent point mutations were intron 2 splice mutations (c... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5336766 Fri, 21 Oct 2011 04:00:00 +0100 5336766 http://www.medworm.com/index.php?rid=5336771&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1285913 Exp Clin Endocrinol Diabetes 2011; 119: 544-548DOI: 10.1055/s-0031-1285913We hypothesized that overweight children with growth hormone deficiency (GHD) demonstrate a lower response to growth hormone (GH) as a result of a misclassification since obesity is associated with lower GH peaks in stimulation tests.Anthropometric data, response, and responsiveness to GH in the first year of treatment were compared in 1.712 prepubertal children with GHD from the German KIGS database according to BMI (underweight=group A, normal weight=group B, overweight=group C) (median age: group A, B, C: 7.3, 7.28, and 8.4 years).Maximum GH levels to tests (median: group A, B, C: 5.8, 5.8, and 4.0 µg/ml) were significantly lower in group C. IGF-I SDS levels were not different between the groups. Growth velocit... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5336771 Mon, 17 Oct 2011 04:00:00 +0100 5336771 http://www.medworm.com/index.php?rid=5336767&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1284368 Exp Clin Endocrinol Diabetes 2011; 119: 525-529DOI: 10.1055/s-0031-1284368Ectopic ACTH production causes 10% of Cushing’s syndromes. The diagnostic workup is difficult, can last more than 6 months (> 50% of cases), and the underlying tumour is still frequently not located (12%). Carcinoid tumours of the appendix are frequent and are revealed in 0.3% of patients undergoing routine appendectomy. However, neuroendocrine tumours of the appendix with ACTH production are an extremely rare entity.Here we report the case of a female patient with clinically overt Cushing’s syndrome due to ectopic ACTH-production from a carcinoid tumour of the appendix. During the diagnostic workup, repeated endocrine tests, multiple different imaging modalities and frequent and lengthy hospitalisations wer... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5336767 Mon, 17 Oct 2011 04:00:00 +0100 5336767 http://www.medworm.com/index.php?rid=5226886&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1284366 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1284366The clinical picture of pituitary abscesses may resemble features of other pituitary pathologies including endocrine deficiencies. The characteristic radiological changes, namely the ring enhancement, may aid in the diagnostic work-up of this very rare condition.A 40-year-old patient with longstanding HIV infection presented with headache and fatigue. Testing for pituitary function confirmed panhypopitutarism. MRI scanning demonstrated an inhomogeneous pituitary gland with ring-like enhancement and sphenoid sinus mucosa thickening. Transsphenoidal surgery was performed. Histologically CD68 positive macrophages were found supporting the diagnosis of infectious hypophysitis. Under hormone replacement therapy and retroviral treatment the ... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5226886 Thu, 15 Sep 2011 04:00:00 +0100 5226886 http://www.medworm.com/index.php?rid=5226882&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1285833 The objective of this study was to investigate platelet mitochondria to evaluate whether type 2 diabetes associated mitochondrial dysfunction is evident in circulating cells.A pilot study of mitochondrial respiratory function and proteomic changes comparing platelets extracted from insulin sensitive (n=8) and type 2 diabetic subjects (n=7).In-situ platelet mitochondria show diminished oxygen consumption and lower oxygen-dependent ATP synthesis in diabetic vs. control subjects. Mass spectrometric identification and confirmatory immunoblot analysis identifies induction of the mitochondrial anti-oxidant enzymes superoxide dismutase 2 and thioredoxin-dependent peroxide reductase 3 in platelets of diabetic subjects. As oxidative stress upregulates anti-oxidant enzymes we assessed mitochondrial ... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5226882 Thu, 15 Sep 2011 04:00:00 +0100 5226882 http://www.medworm.com/index.php?rid=5226880&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1284432 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1284432There is increasing evidence that T-regulatory (Treg) cells could be used to prevent or cure autoimmune diseases including type 1 diabetes mellitus (T1DM). The aim of the present study was to verify the hypothesis that functional Treg cells can be generated from conventional T-cells separated from a small amount of peripheral blood of children with newly diagnosed T1DM (N=25).CD4+CD25- cells were cultured with Treg expander (CD3/CD28) and IL-2 for generating de novo Treg cells. The assessment of the expression of selected genes and proteins critical to Treg function and the proliferation assays were performed with the use of real-time RT-PCR and flow cytometry.After a 4-week stimulation with Treg expander and IL-2, the percentage of T-... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5226880 Thu, 15 Sep 2011 04:00:00 +0100 5226880 http://www.medworm.com/index.php?rid=5226878&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1284378 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1284378Diabetes mellitus classified as Maturity Onset Diabetes of the Young (MODY) is characterized by autosomal dominant inheritance with insulin secretory disturbances.In 2 siblings with diabetes mellitus manifestation at age under 25 years, low fasting glucose levels, severely elevated glucose levels upon glucose challenge and absent autoantibodies for IA2 and GAD clarification for MODY was sought. Mutational screening for MODY 1–3 mutations was carried out by direct sequencing followed by multiplex ligation-dependent probe amplification (MLPA).We identified a mutation within the hepatic nuclear factor 4A (HNF-4A) gene hitherto unreported for MODY-1. A causative role of the mutation is not proven, however in the 2 index patients similar ... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5226878 Thu, 15 Sep 2011 04:00:00 +0100 5226878 http://www.medworm.com/index.php?rid=5226876&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1285912 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1285912To investigate if serum 25-hydroxyvitamin D (25(OH)D) is related to the whole Body Surface Area (BSA), and to several other anthropometric and environmental factors.Serum 25(OH)D was determined in 489 apparently healthy subjects (346 women and 143 men, mean age 43.9 years) in April and May. From all subjects the following data were available: height, body weight, waist to hip ratio, BSA, BMI, environment of work (indoors vs. outdoors), habit of regularly sunbathing during previous summer(s), fear of sun, dwelling in city or village, and skin color.Approximately 43% of the participants had serum 25(OH)D levels between 10 and 20 ng/ml, 44% had values between 20.1 and 30 ng/ml, whereas about 5% had values below 10 ng/ml and only 9% ... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5226876 Thu, 15 Sep 2011 04:00:00 +0100 5226876 http://www.medworm.com/index.php?rid=5226885&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1284377 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1284377Cardiovascular risk among diabetic patients is at least twice as much the one for non-diabetic individuals and even greater when diabetic women are considered. Heart failure (HF) is a common unfavorable outcome of cardiovascular disease in diabetes. However, since the comparison among sexes of heart failure prevalence in diabetic patients remains limited, this study is aimed at expanding the information about this point.We have evaluated the association between diabetes and HF by reviewing the medical records of all subjects discharged from the Internal Medicine and Cardiology Units of all hospitals in the Tuscany region, Italy, during the period January 2002 through December 2008. In particular we sought concomitance of ICD-9-CM codes... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5226885 Tue, 13 Sep 2011 04:00:00 +0100 5226885 http://www.medworm.com/index.php?rid=5226884&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1285911 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1285911Metformin is the oral drug of first choice in type 2 diabetes. Therefore a large number of patients undergoing bariatric surgery will be on Metformin treatment. However, use of Metformin has been associated with lactate acidosis. Weight loss following bariatric surgery is most pronounced during the first weeks after the operation and this creates a phase of negative energy balance with ketone body formation. To shed more light on this situation we measured ketone bodies in 90 patients 5 days–18 months after bariatric surgery. Ketone bodies were markedly elevated during the first 3–4 months. Metformin use should therefore be critically reconsidered after bariatric operations.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle i... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5226884 Tue, 13 Sep 2011 04:00:00 +0100 5226884 http://www.medworm.com/index.php?rid=5226883&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1286296 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1286296To demonstrate whether in distal symmetric polyneuropathy (DSPN) in diabetes there are differences between patients with and without neuropathic pain and whether pain is associated with demographic, clinical and electrophysiological variables.We prospectively enrolled 154 consecutive patients (mean age 67 years, 64% men) in an electromyography (EMG) lab. The differences were calculated between DSPN patients with (no.78) and without neuropathic pain (no.76) relating to age, sex, BMI, type, duration, treatment and complications of diabetes, HbA1c, type and duration of DSPN symptoms, DSPN clinical severity score (with Diabetic Neuropathic Index-DNI), electrophysiological findings of lower limb muscles and nerves.The differences between DS... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5226883 Tue, 13 Sep 2011 04:00:00 +0100 5226883 http://www.medworm.com/index.php?rid=5226881&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1284367 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1284367Obesity is one major risk factor for the development of arterial hypertension, and the development of obesity-related hypertension has been associated with increased plasma aldosterone levels. Our previous work shows a direct stimulatory effect of adipokines on aldosterone secretion from human adrenocortical cells, mediated via ERK1/2-dependent upregulation of steroid acute regulatory protein (StAR) activity. Recent evidence also indicates the involvement of the Wnt-signaling pathway in fat cell-mediated aldosterone secretion. Wnt-signaling molecules are secreted by adipocytes and regulate the activity of SF-1, a key transcription factor in adrenal steroidogenesis. The goal of this study was to investigate the cellular mechanisms of ad... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5226881 Tue, 13 Sep 2011 04:00:00 +0100 5226881 http://www.medworm.com/index.php?rid=5226879&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1283123 Exp Clin Endocrinol Diabetes 2011; 119: 497-501DOI: 10.1055/s-0031-1283123Statins have marked beneficial effects on lipid profile, but also have pleiotropic actions. A previous study in an iodine-deficient area suggested that statin use is associated with reduced thyroid volume and nodularity. We performed this study to investigate how long-term statin use in type 2 diabetic patients affects thyroid nodularity in iodine-sufficient area.We recruited euthyroid type 2 diabetic patients, receiving statin therapy continuously for at least 5 years (statin group) and, age and sex matched statin-naive type 2 diabetic patients (control group). Subjects with past history of cancer, thyroid disease or treatment with lithium or amiodarone; family history of thyroid cancer; palpable goiter or thyroid n... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5226879 Tue, 13 Sep 2011 04:00:00 +0100 5226879 http://www.medworm.com/index.php?rid=5226877&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1285910 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1285910Although several studies have found an association between tobacco smoking and thyroid disorders such as Graves’ disease, Graves’ ophtalmopathy, goiter and thyroid multi nodularity, the effect of smoking on thyroid function is controversial.The aim of this study was to evaluate the association between smoking and serum TSH concentration and the presence of thyroperoxidase antibody (TPO Ab) in Tehranian adults.In this cross sectional community based survey, 1 581 randomly selected subjects with no history of thyroid disorders were studied within the framework of Tehran Lipid and Glucose Study. Serum TSH and TPOAb were measured in a fasting serum sample. Weight and height were measured and BMI was calculated. Smokers were classifie... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5226877 Tue, 13 Sep 2011 04:00:00 +0100 5226877 http://www.medworm.com/index.php?rid=5226875&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1285832 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1285832Obesity and type 2 diabetes mellitus are multifactorial health threats caused by a complex interplay between genetic predisposition and the environment with dramatically increasing worldwide prevalence. The role of heritability in their etiology is well recognized, however, the numerous attempts made in order certain genetic variants determining individual susceptibility to be identified have had limited success, until recently. At present the advancements in human genetics and the utilization of the genome-wide association approach have led to the identification of over 20 genetic loci associated with, respectively obesity and type 2 diabetes. Most of the genes identified to date, however, have modest effect on disease risk suggesting... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5226875 Tue, 13 Sep 2011 04:00:00 +0100 5226875 http://www.medworm.com/index.php?rid=5226874&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280807 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1280807Type 1 diabetes mellitus (T1DM) is mainly caused by reduction of the endogenous insulin secretion due to autoimmune destruction of pancreatic β cells, and a promising therapeutic approach for T1DM is pancreas and islet cell replacement. The major obstacle is the limited source of insulin-producing cells. Here, we report an efficient approach to induce human adipose-derived stromal cells (hADSCs) to differentiate into insulin-producing cells, with glucagon-like peptide-1 (GLP-1). hADSCs were successfully isolated from the adipose tissue, with adipogenic and osteogenic differentiation potency. Islet-like cell clusters formed in the culture, which was enhanced with the treatment of GLP-1. Reverse transcription polymerase chain reaction a... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5226874 Tue, 13 Sep 2011 04:00:00 +0100 5226874 http://www.medworm.com/index.php?rid=5226873&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1284430 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1284430Circulating obestatin is lowered by food intake, but factors involved in obestatin regulation remain unclear. The aim of this study was to determine whether intravenous glucose or insulin infusion lowers obestatin. Rats were infused over 3 h with either A. saline (controls); B. dextrose to steady state blood glucose ~16.7 mM, or C. insulin 7.5 mU/kg.min, plus dextrose as needed to clamp to euglycemic basal concentrations. During 3 h of infusion, group B had significantly greater (P<0.01) glucose, 18.75±1.27 mM, than groups A (6.10±0.33 mM) or C (6.19±0.18 mM). Groups B and C had hyperinsulinemia at the end of the 3 h infusion (1.02±0.03 ng/ml, 1.07±0.02 ng/ml) compared with saline-infused (0.38±0.01 ng/ml... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5226873 Tue, 13 Sep 2011 04:00:00 +0100 5226873 http://www.medworm.com/index.php?rid=5089024&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1275277 Conclusions: Persons that changed their fund had a much lower prevalence of diabetes than those who did not. Most of this difference could be explained by age. We found quite similar figures for hypertension, a more prevalent disease. However, ORs were significant in all described models, probably due to a higher statistical power.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5089024 Mon, 01 Aug 2011 23:00:00 +0100 5089024 http://www.medworm.com/index.php?rid=5089023&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1279713 Conclusions: Add-on therapy with growth factors and active skin substitutes for treating uncomplicated DFU could be an alternative to SWC alone. For explicit recommendations further studies with stronger evidence are necessary.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5089023 Mon, 01 Aug 2011 23:00:00 +0100 5089023 http://www.medworm.com/index.php?rid=5089022&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1269846 Conclusions: In morbid obesity: (1) Subcutaneous adipose tissue releases interleukin-6 which could then mediate insulin resistance in skeletal muscle. (2) Although there is increased secretion of leptin by the subcutaneous adipose tissue, leptin levels are not correlated to the sensitivity of glucose metabolism to insulin in muscle.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5089022 Mon, 01 Aug 2011 23:00:00 +0100 5089022 http://www.medworm.com/index.php?rid=5089021&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1284365 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1284365Abstract[...]George Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5089021 Mon, 01 Aug 2011 23:00:00 +0100 5089021 http://www.medworm.com/index.php?rid=5089020&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1284338 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1284338[...]George Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5089020 Mon, 01 Aug 2011 23:00:00 +0100 5089020 http://www.medworm.com/index.php?rid=5089019&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1284370 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1284370Abstract[...]George Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5089019 Mon, 01 Aug 2011 23:00:00 +0100 5089019 http://www.medworm.com/index.php?rid=5089018&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1284369 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1284369Abstract[...]George Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=5089018 Mon, 01 Aug 2011 23:00:00 +0100 5089018 http://www.medworm.com/index.php?rid=4999733&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1279740 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1279740AbstractTo get more insight into molecular mechanisms underlying oxidative stress and its link with insulin resistance, oxidative stress parameters, as well as, antioxidant enzyme activities were studied in young, non-obese women with polycystic ovary syndrome (PCOS). Study was performed in 34 PCOS women and 23 age and body mass index (BMI)-matched healthy controls. Plasma nitrotyrosine and malondialdehyde (MDA), representative byproducts of protein and lipid oxidative damage, were determined by enzyme immunoassay. Antioxidant enzyme activities, superoxide dismutase (SOD) and glutathione peroxidase (GPX) were studied spectrophotometrically. Insulin resistance was calculated using homeostasis assessment model (HOMA-IR). Plasma nitrotyro... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4999733 Thu, 09 Jun 2011 23:00:00 +0100 4999733 http://www.medworm.com/index.php?rid=4999732&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1279714 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1279714AbstractDiabetes mellitus may result in taste disturbance. The present study has revealed that cell apoptosis of taste buds in circumvallate papillae may contribute to the taste disturbance in a rat model of type2 diabetes. Type2 diabetes was induced in Wistar rats by feeding them with a high-fat diet (30% fat), and a single intraperitoneal injection of streptozotocin (30 mg/kg). The increased cell apoptosis of taste buds in circumvallate papilla sections was detected by TUNEL staining in diabetic rats, and the ultrastructure was further examined by transmission electronic microscopy. Immunohistochemical and Western blot analyses revealed the downregulation of Bcl-2, upregulation of Bax, and increased activation of caspase-9 and ... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4999732 Thu, 09 Jun 2011 23:00:00 +0100 4999732 http://www.medworm.com/index.php?rid=4999731&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1279703 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1279703AbstractRestricting-type of anorexia nervosa (AN-R) is a serious disorder affecting adolescents and young adults, and decreases quality of life over long period. Successful weight restoration is an important prognostic factor for disease outcome; however, the underlying mechanism of refeeding-resistance, a core psychopathology relevant to ‘ambivalent’ eating behaviors, remains unclear in this disorder. Obestatin plays an important role in the regulation of growth hormone release, appetite, and energy metabolism. However, the progress of these patients and changes in the levels of obestatin during treatment were not reported. The purpose of this study was to determine the changes in obestatin levels when energy intake increa... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4999731 Thu, 09 Jun 2011 23:00:00 +0100 4999731 http://www.medworm.com/index.php?rid=4999730&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1279741 Conclusions: Maternal thyroid autoimmunity and transplacental passage of autoantibodies against thyroid antigens may affect the generation or expansion of cells with NK activity and the secretion of inflammatory cytokines.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4999730 Thu, 09 Jun 2011 23:00:00 +0100 4999730 http://www.medworm.com/index.php?rid=4999729&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1275661 In conclusion, we showed that serum sclerostin levels are decreased presumably through endogenous PTH elevation in postmenopausal women with pHPT, compared with the patients with postmenopausal osteoporosis.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4999729 Thu, 09 Jun 2011 23:00:00 +0100 4999729 http://www.medworm.com/index.php?rid=4999728&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1279704 Conclusion: Although objective tumor res­ponse rates were low, the CVD regimen allowed disease stabilization for a substantial period of time and had acceptable toxicity. After initial surgery, chemotherapy may therefore be considered as a medical treatment option.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4999728 Thu, 09 Jun 2011 23:00:00 +0100 4999728 http://www.medworm.com/index.php?rid=4999727&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1277193 Conclusion: Exposure of diabetic rats to tobacco smoke prior to pregnancy increased fetal DNA damage, but failed to induce teratogenicity. Thus, these results reinforce the importance for women to avoid exposure to cigarette smoke long before they become pregnant.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4999727 Thu, 09 Jun 2011 23:00:00 +0100 4999727 http://www.medworm.com/index.php?rid=4999726&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1269886 Conclusion: This study showed that the experimental model used led to mild hyperglycemia during pregnancy, although it did not lead to increased macrosomic fetus rates. The hyperglycemic maternal environment caused metabolic alterations, including increased triglyceride and total cholesterol concentrations, and elevated oxidative stress, contributing to increase fetal visceral anomalies.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4999726 Thu, 09 Jun 2011 23:00:00 +0100 4999726 http://www.medworm.com/index.php?rid=4999725&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1279712 Conclusions: Poor glycemic control may increase oxidative stress in the erythrocytes of type 2 diabetic men. Good physical fitness seems to be associated with increased peroxiredoxin contents. Therefore, it can be speculated that physical training can contribute to the improvement of the erythrocyte peroxiredoxin system to counteract free radicals in type 2 diabetic patients.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4999725 Thu, 09 Jun 2011 23:00:00 +0100 4999725 http://www.medworm.com/index.php?rid=4806672&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1273738 In conclusion, although total fat mass is the strongest predictor of circulating leptin, adipose tissue cellularity play an additional independent and important role.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4806672 Mon, 09 May 2011 23:00:00 +0100 4806672 http://www.medworm.com/index.php?rid=4795512&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1277153 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1277153AbstractA recent study reported a significant association between the T-allele in intron 18 of the acetyl-coenzyme A carboxylase beta (ACACB) gene (C>T polymorphism) and nephropathy caused by diabetes mellitus (DM). Considering the involvement of chronic inflammation in the pathophysiology of DM, the present study investigated an association between the ACACB gene polymorphism and high-sensitivity C-reactive protein (hsCRP) in a prediabetic and diabetic population. Anthropometric and biochemical variables including hsCRP were measured among 91 Japanese subjects (mean age: 69 years) with a hemoglobin A1c level of ≥5.6% and no history of cardiovascular disease. All subjects were genotyped by an allele-specific DNA assay. The sub... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4795512 Thu, 05 May 2011 23:00:00 +0100 4795512 http://www.medworm.com/index.php?rid=4795511&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1277137 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1277137AbstractIn the evaluation of patients presenting with altered mental function searching for underlying medical conditions is necessary. Abnormal thyroid function has long been implicated in mood changes with the classic associations of depression occurring together with hypothyroidism and of mania along with hyperthyroidism. We here report 3 patients who presented with symptoms consistent with acute manic episode diagnosed using DSM IV-TR criteria and who were found to have primary hypothyroidism biochemically. This led to a review of the literature on this phenomenon resulting in the identification of 10 reports of mania and associated thyroid profiles consistent with primary hypothyroidism. All 3 of our patients improved clinically a... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4795511 Thu, 05 May 2011 23:00:00 +0100 4795511 http://www.medworm.com/index.php?rid=4795510&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1277138 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1277138AbstractAims: The relationship between alcohol drinking and metabolic syndrome (MetS) and its components are not fully confirmed, we examined relationship between alcohol drinking and MetS and its components.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4795510 Thu, 05 May 2011 23:00:00 +0100 4795510 http://www.medworm.com/index.php?rid=4795509&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1277140 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1277140AbstractAim: To evaluate clinical management of patients with Turner syndrome in one center over a long period.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4795509 Thu, 05 May 2011 23:00:00 +0100 4795509 http://www.medworm.com/index.php?rid=4795508&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1269882 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1269882AbstractBackground: PCOS is presented by a broad spectrum of menstrual irregularities appearing often at puberty or later on during the reproductive years in women suffering from this multifaceted syndrome. To our knowledge, there is no evidence to suggest whether the time of onset of menstrual irregularities (peri or post pubertal) indicates a differential metabolic and/or hormonal profile as well as ovarian ultrasonographic findings, in adulthood in women with PCOS.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4795508 Thu, 05 May 2011 23:00:00 +0100 4795508 http://www.medworm.com/index.php?rid=4795507&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1277162 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1277162AbstractIntroduction: The most common form of familial hypophosphatemic rickets is X-linked. PHEX has been identified as the gene defective in this phosphate wasting disorder leading to decreased renal phosphate reabsorption, hypophosphatemia and inappropriate concentrations of 1,25-dihydroxyvitamin D in regard to hypophosphatemia. Clinical manifestation are skeletal deformities, short stature, osteomalacia, dental abscesses, bone pain, and loss of hearing.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4795507 Thu, 05 May 2011 23:00:00 +0100 4795507 http://www.medworm.com/index.php?rid=4795506&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1270466 In this study, we aimed to evaluate the mortality rate after hip fracture and determine the predictors of mortality in diabetic patients.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4795506 Thu, 05 May 2011 23:00:00 +0100 4795506 http://www.medworm.com/index.php?rid=4795505&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1277141 This study aimed to evaluate the predictive value of these anthropometries for metabolic abnormalities and related diseases in Chinese adults.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4795505 Thu, 05 May 2011 23:00:00 +0100 4795505 http://www.medworm.com/index.php?rid=4795504&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1275662 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1275662AbstractExisting data show that C-peptide (CP) prevents or ameliorates diabetes-related complications mainly by improving microcirculation and perhaps metabolism. Although effects of CP on muscle glucose consumption are relatively well studied, its effects on adipose tissue, a key organ involved in metabolism, are not well known. Therefore, the aim of this study was to examine the effects of CP on basal and stimulated lipolysis and glucose consumption in rat retroperitoneal (RP) adipose tissue, using an ex-vivo organ culture setting. The RP adipose tissue was excised from adult male rats, minced and subjected to ex-vivo culture for 24 h. The tissue fragments were then weighted and distributed into a 24-well culture plate. The wel... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4795504 Thu, 05 May 2011 23:00:00 +0100 4795504 http://www.medworm.com/index.php?rid=4795503&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1275699 We describe 2 unrelated patients with clinical and molecular features typical of Shwachman-Diamond syndrome and type 1 diabetes mellitus. In addition, we report the occurrence rate of type 1 diabetes mellitus in the Italian registry for Shwachman-Diamond syndrome, which is low (3.23%) but increased at least 30-fold over the type 1 diabetes mellitus occurrence rate in the general population. No evidence of a direct correlation between Shwachman-Diamond syndrome and type 1 diabetes mellitus have been reported, therefore the presence of both diseases in the same patient might be a chance association, however we suggest that the defects in immune regulation of Shwachman-Diamond syndrome might play a role in the development of type 1 diabetes mellitus.[...]© J. A. Barth Verlag in Georg Thieme ... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4795503 Thu, 05 May 2011 23:00:00 +0100 4795503 http://www.medworm.com/index.php?rid=4795502&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1277139 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1277139AbstractObese children have a twofold increased risk of fracture of the forearm compared to non-obese children.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4795502 Thu, 05 May 2011 23:00:00 +0100 4795502 http://www.medworm.com/index.php?rid=4795501&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1277136 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1277136AbstractBackground: According to the classification of polycystic ovary syndrome (PCOS) published by the Androgen Excess Society (AES), 10 different phenotypes of the condition are possible. The question remains of whether using these phenotypes might enable us to identify women with impaired insulin resistance or an impaired lipid profile among patients with PCOS.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4795501 Thu, 05 May 2011 23:00:00 +0100 4795501 http://www.medworm.com/index.php?rid=4687026&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1273747 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1273747AbstractTo assess physical activity in patients with type 1 diabetes an innovative telemedical support system has been developed. The aim of the feasibility trial was to prove its use in a clinical setting.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4687026 Tue, 05 Apr 2011 23:00:00 +0100 4687026 http://www.medworm.com/index.php?rid=4687025&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1275288 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1275288AbstractIntroduction: While altered cortisol concentrations have been observed in subjects with type 2 diabetes their circadian cortisol profile is unknown.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4687025 Tue, 05 Apr 2011 23:00:00 +0100 4687025 http://www.medworm.com/index.php?rid=4687024&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1275289 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1275289AbstractObjective: Several studies have shown increased oxidative stress in patients with pre-diabetes and newly diagnosed Type 2 diabetes mellitus (T2DM). It has been proposed that oxidative stress initiates insulin resistance in genetically predisposed individuals. The aim of this study was to evaluate the markers of oxidative stress in the offspring of patients with T2DM.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4687024 Tue, 05 Apr 2011 23:00:00 +0100 4687024 http://www.medworm.com/index.php?rid=4687023&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1270478 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1270478AbstractBackground: Gestational diabetes mellitus (GDM) is a metabolic condition that can cause severe fetal and maternal morbidity. Early diagnosis and treatment of GDM can significantly prevent maternal and perinatal morbidity.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4687023 Tue, 05 Apr 2011 23:00:00 +0100 4687023 http://www.medworm.com/index.php?rid=4687022&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1273737 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1273737AbstractThe purpose of this phase 2, multicentre, randomized, double-blind, placebo-controlled, 12-week dose-ranging study was to assess the efficacy, safety, and tolerability of the dipeptidyl peptidase-IV (DPP-IV) inhibitor PF-734200 in adult subjects with type 2 diabetes who were on a stable dose of metformin. Men and women with inadequate glycaemic control with metformin as their sole diabetes medication were randomized to placebo or PF-734200 2 mg, 5 mg, 10 mg, or 20 mg every day. A population subset underwent mixed meal tolerance tests (MMTT) at baseline and week 12. A total of 301 subjects were treated. At week 12, PF-734200 doses of ≥5 mg produced a statistically significant reduction in haemoglobin A1C (HbA1c) compared w... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4687022 Tue, 05 Apr 2011 23:00:00 +0100 4687022 http://www.medworm.com/index.php?rid=4687021&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1271705 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1271705AbstractAim of the study: Proteomic approach was applied to identify differential protein expressed in brain of rats with type 1 diabetes mellitus (T1DM) in order to search for potential biomarkers for pathological changes of brain with T1DM.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4687021 Tue, 05 Apr 2011 23:00:00 +0100 4687021 http://www.medworm.com/index.php?rid=4687020&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1273746 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1273746AbstractObjective: Deutsche BKK, a German health insurance company, initiated in 1997 a diabetes quality improvement programme. Changes in HbA1c and blood pressure (BP) from 1997 to 2006 are presented.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4687020 Tue, 05 Apr 2011 23:00:00 +0100 4687020 http://www.medworm.com/index.php?rid=4687019&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1273770 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1273770AbstractThe present study was undertaken to compare the efficacy of pitavastatin and colestimide in patients with diabetes mellitus complicated by hyperlipidemia and metabolic syndrome. 48 diabetic patients with metabolic syndrome were randomly assigned to a pitavastatin group or colestimide group. The clinical parameters, serum lipids, fasting (FPG) and postprandial plasma glucose(PPG), HOMA-IR, hemoglobin A1c(HbA1c), hs-CRP and urinary albumin were measured before/after 24-week administration. Treatment with pitavastatin reduced LDL-C and TG, while that with colestimide significantly reduced waist circumference, BMI, LDL-C, HbA1c, FPG, PPG, HOMA-R , hs-CRP and urinary albumin. Percent improvement in LDL-C was greater in the pitavasta... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4687019 Tue, 05 Apr 2011 23:00:00 +0100 4687019 http://www.medworm.com/index.php?rid=4687018&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1267953 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1267953AbstractObjective: Accumulation of advanced glycation end products (AGEs) is associated with age- and diabetes-related disease. The aim of the present study is to investigate the effects of metformin or pioglitazone on serum pentosidine levels, a well-defined AGE, in type 2 diabetes.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4687018 Tue, 05 Apr 2011 23:00:00 +0100 4687018 http://www.medworm.com/index.php?rid=4687017&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1268426 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1268426AbstractProinflammatory cell activation via the receptor for advanced glycation end products (RAGE) pathway may play a central pathogenetic role in atherosclerosis. Since S100A8/A9 was recently identified as ligand of RAGE, we determined the effects of proinflammatory cytokines on RAGE-mediated induction of gene expression of S100A8 and S100A9. mRNA levels of S100A8 and S100A9 were upregulated following cytokine stimulation with IL-6 (1, 10, 100 ng/ml) or TNFα (10 ng/ml) in human THP-1 cells. Preincubation of cells with 2000 ng/ml AGE (advanced glycation end products) before cytokine stimulation resulted in upregulation of RAGE. Pretreatment of THP-1 with AGE followed by stimulation with IL-6 (10 ng/ml) or TNFα (10 ng/ml) fur... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4687017 Tue, 05 Apr 2011 23:00:00 +0100 4687017 http://www.medworm.com/index.php?rid=4677843&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1275276 Exp Clin Endocrinol Diabetes 2011; 119: 218-220DOI: 10.1055/s-0031-1275276AbstractIntroduction: Fructose is a simple carbohydrate that should be ingested in a restricted manner. However, current data suggest increased daily consumption of fructose which may lead to an increased incidence of diseases such as obesity, diabetes and co-morbidities associated with excess weight. Thus, the objective of the present study was to assess the effect of the ingestion of different fructose sources on weight gain, glycemia and serum triglyceride levels in rats.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4677843 Sun, 03 Apr 2011 23:00:00 +0100 4677843 http://www.medworm.com/index.php?rid=4677842&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1271691 Exp Clin Endocrinol Diabetes 2011; 119: 201-207DOI: 10.1055/s-0031-1271691AbstractAim: Assess the prevalence of thyroid dysfunction in patients with type 2 diabetes (T2D) in Segovia (Spain).[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4677842 Sun, 03 Apr 2011 23:00:00 +0100 4677842 http://www.medworm.com/index.php?rid=4795514&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1267201 Exp Clin Endocrinol Diabetes 2011; 119: 186-189DOI: 10.1055/s-0030-1267201AbstractBackground: Morbidly obese patients undergoing gastric bypass surgery experience early satiety soon after the surgery; the mechanism of this effect is poorly understood. As blood glucose concentration plays a role in appetite regulation in humans, we hypothesized that after gastric bypass surgery glucose absorbed mainly in jejunum leads to a greater rise in plasma glucose that if it is ingested in stomach.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4795514 Thu, 03 Mar 2011 00:00:00 +0100 4795514 http://www.medworm.com/index.php?rid=4545869&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1267201 Exp Clin Endocrinol Diabetes 2011; 119: 186-189DOI: 10.1055/s-0030-1267201AbstractBackground: Morbidly obese patients undergoing gastric bypass surgery experience early satiety soon after the surgery; the mechanism of this effect is poorly understood. As blood glucose concentration plays a role in appetite regulation in humans, we hypothesized that after gastric bypass surgery glucose absorbed mainly in jejunum leads to a greater rise in plasma glucose that if it is ingested in stomach.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4545869 Thu, 03 Mar 2011 00:00:00 +0100 4545869 http://www.medworm.com/index.php?rid=4545868&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1271628 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1271628AbstractHypogonadal males have recently been shown to present prolonged QT interval, an electrocardiographic measure indicative of risk for fatal cardiac arrhythmias. Excess cortisol secretion induces low testosterone levels in male patients with Cushing's disease but no study has yet evaluated if this is accompanied by changes in QT interval duration. We therefore decided to evaluate whether male patients with Cushing's disease present changes in QT interval duration. QT interval was measured in electrocardiographic readings from 19 men and 35 women with Cushing's disease and age- and sex-matched controls were used for comparison. QT interval was corrected for heart rate according to Bazett's formula (QTc) and QTc >440 msec and &gt... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4545868 Thu, 03 Mar 2011 00:00:00 +0100 4545868 http://www.medworm.com/index.php?rid=4545867&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1269912 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1269912AbstractBackground: Omentin has recently been characterized as a potent insulin-sensitizing adipokine, but its pathophysiologic roles in humans remain largely unknown.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4545867 Thu, 03 Mar 2011 00:00:00 +0100 4545867 http://www.medworm.com/index.php?rid=4545866&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1271629 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1271629AbstractPrimary adrenal lymphoma (PAL) is an extremely rare entity, with approximately 70 cases reported in the English literature and 120 cases worldwide. Here we report the cases of a 53-year-old and a 62-year-old male patient and a 60-year-old female patient affected by large B-cell non-Hodgkin lymphoma of the adrenal gland. We summarize the diagnostic approaches that confirmed the diagnosis of PAL and describe individual treatment outcomes after therapy. Based on these case reports and a review of the literature patients are usually in the 6th or 7th decade of life and present with B-symptoms or rapidly progressive adrenal insufficiency in case of bilateral involvement. The identification of bilateral adrenal masses often causes a ... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4545866 Thu, 03 Mar 2011 00:00:00 +0100 4545866 http://www.medworm.com/index.php?rid=4545865&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1270511 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1270511AbstractPheochromocytoma (PHEO) and paraganglioma (PGL) are rare catecholamine-secreting neuroendocrine tumors arising from chromaffin tissue and can occur within the adrenal medulla (PHEO) or extra-adrenal sites (PGL). The most common site for PGL is the organ of Zuckerkandl, extra-adrenal chromaffin tissue near the origin of the inferior mesenteric artery.We here present 2 patients with extra-adrenal PGL in the organ of Zuckerkandl, located by iodine-123-metaiodobenzylguanadine (123I-MIBG) scintigraphy and thereafter treated surgically or with iodine-131-metaiodobenzylguanadine (131I-MIBG). First, in a 15-year-old boy with clinical suspicion of PHEO, the diagnosis was established by biochemical evaluation and confirmed by further ima... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4545865 Thu, 03 Mar 2011 00:00:00 +0100 4545865 http://www.medworm.com/index.php?rid=4545864&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1271668 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0031-1271668AbstractBackground: Most non diabetic patients admitted with acute coronary syndrome (ACS) demonstrate an abnormality in glucose homeostasis. It was claimed that an oral glucose tolerance test (OGTT) undertaken during the admission is a good indicator of the patient's glycemic status.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4545864 Thu, 03 Mar 2011 00:00:00 +0100 4545864 http://www.medworm.com/index.php?rid=4545863&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1269883 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1269883AbstractObjectives: Polycystic ovary syndrome (PCOS) and/or insulin resistance (IR) are frequent conditions in women choosing assisted reproduction techniques (ART). However, infertility work-up has to include testing of insulin sensitivity to diagnose IR. It was the aim of the study to analyze the frequency of impaired glucose tolerance (IGT) or gestational diabetes (GD) in the first weeks of gestation after ART in women receiving metformin.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4545863 Thu, 03 Mar 2011 00:00:00 +0100 4545863 http://www.medworm.com/index.php?rid=4545862&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1270510 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1270510AbstractBB rats develop type 1 diabetes and WOKW rats facets of the metabolic syndrome. Both strains are common the RT1u haplotype of major histocompatibility complex (MHC) which is essential for type 1 diabetes development in BB rats (Iddm1). However, BB rats need an additional gene (lymphopenia, Iddm2, Gimap5) to develop type 1 diabetes. Because WOKW lacks Iddm2 and does not develop hyperglycemia a congenic WOKW rat strain was generated recombining the region of chromosome 4 with Iddm2 onto the genetic background of WOKW rats (WOKW.4BB). These newly established rats and their parental WOKW rats were genetically and phenotypically characterized. Congenic WOKW.4BB rats showed a lymphopenic phenotype. The sequences of the highly polymor... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4545862 Thu, 03 Mar 2011 00:00:00 +0100 4545862 http://www.medworm.com/index.php?rid=4795513&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1269847 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1269847AbstractIntroduction: The prevalence of treated diabetes in Germany and direct health care costs of individuals with diabetes were analysed for the 8-year period from 2000 to 2007, based on administrative data. Special interest was given to the incremental costs attributed to diabetes.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4795513 Mon, 24 Jan 2011 00:00:00 +0100 4795513 http://www.medworm.com/index.php?rid=4395398&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1268466 We examined 344 individuals (f/m=216/128, mean age 46±1 years) with an increased risk for type 2 diabetes. Apelin-36 serum levels were measured via ELISA. Endothelial dysfunction and intima media thickness (IMT) were assessed using high resolution ultrasound. Visceral adipose tissue (VAT) was measured with an axial T1-weighted fast spin echo technique with a 1.5 T whole-body imager. According to the study population's age, FMD (6.4±0.2%) and IMT (0.56±0.01 mm) were within the expected ranges. Gender or age had no influence on serum apelin levels. When looked at early stages of atherosclerosis, we could not detect a significant correlation between apelin serum levels and FMD or IMT. Blood pressure as well was unaffected by serum apelin levels. Furthermore, neither parameters of insulin s... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4395398 Mon, 24 Jan 2011 00:00:00 +0100 4395398 http://www.medworm.com/index.php?rid=4395397&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1270440 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1270440AbstractObjective: Because the American Diabetes Association has recently included HbA1c as the primary diagnostic test for the detection of diabetes mellitus (HbA1c ≥6.5%) we investigated its use as screening parameter for diabetes in a cohort at increased risk for the disease.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4395397 Mon, 24 Jan 2011 00:00:00 +0100 4395397 http://www.medworm.com/index.php?rid=4395396&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1269885 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1269885AbstractAim: We investigated the effects of insulin on the electrophysiology of sheep pleural specimens obtained from the upper and lower parts of the pleural cavity and the insulin receptor abundance in these regions.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4395396 Mon, 24 Jan 2011 00:00:00 +0100 4395396 http://www.medworm.com/index.php?rid=4395395&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1269847 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1269847AbstractIntroduction: The prevalence of treated diabetes in Germany and direct health care costs of individuals with diabetes were analysed for the 8-year period from 2000 to 2007, based on administrative data. Special interest was given to the incremental costs attributed to diabetes.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4395395 Mon, 24 Jan 2011 00:00:00 +0100 4395395 http://www.medworm.com/index.php?rid=4395394&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1270467 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1270467AbstractBackground: The frequency of MS increases with age and augments the cardiovascular risk. The criteria for distinguishing MS constantly evolve. The aim of the study was to estimate the reciprocal links between low-grade inflammation, selected serum androgens and prevalence of MS, according to NCEP and IDF criteria, in Polish men over the age of 40.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4395394 Mon, 24 Jan 2011 00:00:00 +0100 4395394 http://www.medworm.com/index.php?rid=4395393&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1269880 This study was designed to examine the effects of hyperthyroidism on the kinetics of glucagon.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4395393 Mon, 24 Jan 2011 00:00:00 +0100 4395393 http://www.medworm.com/index.php?rid=4395392&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1269881 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1269881AbstractObjective: To evaluate the predictive value of disease free status of basal thyroglobulin (Tg) in differentiated thyroid carcinoma (DTC).[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4395392 Mon, 24 Jan 2011 00:00:00 +0100 4395392 http://www.medworm.com/index.php?rid=4395391&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1267249 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1267249AbstractIntroduction: We studied changes of pituitary adenoma volumes in patients treated with octreotide LAR (SSLAR) over 12 months prior to surgery.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4395391 Mon, 24 Jan 2011 00:00:00 +0100 4395391 http://www.medworm.com/index.php?rid=4395390&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1267991 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1267991AbstractIntroduction: To describe the clinical imaging and hormonal characteristics and the natural course of patients with clinically non-functioning pituitary adenomas (NFPAs) presenting at our department from 1984 to 2009.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4395390 Mon, 24 Jan 2011 00:00:00 +0100 4395390 http://www.medworm.com/index.php?rid=4363464&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1262874 Exp Clin Endocrinol Diabetes 2011; 119: 59-61DOI: 10.1055/s-0030-1262874AbstractObjective: We aimed to compare time spent at low glucose level (silent hypoglycemia, glucose <3.0 mmol/l) and glycemic variability in patients who reached HbA1c <7.0% with those who did not.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4363464 Tue, 18 Jan 2011 00:00:00 +0100 4363464 http://www.medworm.com/index.php?rid=4363463&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1265162 Exp Clin Endocrinol Diabetes 2011; 119: 56-58DOI: 10.1055/s-0030-1265162AbstractAims: Waking up in response to an alarm-clock may evoke a stress reaction that leads to rising glucose concentrations.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4363463 Tue, 18 Jan 2011 00:00:00 +0100 4363463 http://www.medworm.com/index.php?rid=4363462&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1268467 Exp Clin Endocrinol Diabetes 2011; 119: 47-52DOI: 10.1055/s-0030-1268467AbstractAims: To investigate associations of obstructive and restrictive patterns of ventilatory dysfunction with insulin resistance and type 2 diabetes mellitus (DM) in Koreans.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4363462 Tue, 18 Jan 2011 00:00:00 +0100 4363462 http://www.medworm.com/index.php?rid=4192512&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1265212 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1265212AbstractThe lipocalins retinol-binding protein (RBP)-4, lipocalin-2 and lipocalin-type prostaglandin D-synthase (L-PGDS) have been suggested to mediate obesity-associated insulin resistance and other metabolic co-morbidities. The role of lipocalins is however controversial and it is unclear whether they have a physiological role in regulation of insulin sensitivity and metabolic function in clinically healthy humans. Therefore, we examined the correlations between serum levels of RBP-4, L-PGDS and lipocalin-2 and insulin sensitivity and other metabolic parameters in non-diabetic subjects selected to display variations in insulin sensitivity. 100 clinically healthy 58-year-old Swedish men were selected by stratified sampling among 818 s... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4192512 Mon, 22 Nov 2010 00:00:00 +0100 4192512 http://www.medworm.com/index.php?rid=4192511&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1267963 In this study, the concentration, isoform, multimer and complex pattern of IGFBP-1 was compared in healthy persons and patients with type 2 diabetes mellitus or with hypoglycemia. Concentrations of insulin and IGFBP-1 were determined by radioimmunoassay. Metal affinity and immunoaffinity chromatography were used for the separation of molecular forms of IGFBP-1, which were detected by immunoblotting and SELDI. The counter directional change in insulin and IGFBP-1 concentrations, expressed as a factor that takes into consideration the rate of insulin increase and IGFBP-1 decrease after glucose intake was approximately twice more pronounced in patients with diabetes than in healthy and hypoglycemic persons. The alteration in the phosphorylation pattern of IGFBP-1 due to diabetes or hypoglycem... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4192511 Mon, 22 Nov 2010 00:00:00 +0100 4192511 http://www.medworm.com/index.php?rid=4192510&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1267964 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1267964AbstractObjective: To investigate the relationship between myostatin serum levels and muscle mass, fat mass and HOMA before and after a 6-month lifestyle intervention program in obese children and adolescents.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4192510 Mon, 22 Nov 2010 00:00:00 +0100 4192510 http://www.medworm.com/index.php?rid=4192509&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1268413 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1268413AbstractAims/Hypothesis: Obesity and insulin resistance are characterized by a chronic and low grade state of inflammation and the pro-inflammatory response of monocytes is affected in type 2 diabetes mellitus (T2D). We aimed to investigate whether LPS-induced monocytic cytokine and chemokine release depends on serum lipoprotein parameters in T2D patients.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4192509 Mon, 22 Nov 2010 00:00:00 +0100 4192509 http://www.medworm.com/index.php?rid=4184439&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1267183 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1267183AbstractObjective: To examine the sensitivity and specificity of HbA1c testing for the diagnosis of type 2 diabetes in high-risk adults in China and to compare the cardiaovascular risk factors between 2 groups of patients with glycemic status classified by the 2 different tests.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4184439 Fri, 19 Nov 2010 00:00:00 +0100 4184439 http://www.medworm.com/index.php?rid=4363460&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1267244 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1267244AbstractObjective: To assess the efficacy of different dosing intervals of lanreotide, Somatuline Autogel® (Lan-ATG) 120 mg in patients with acromegaly, previously treated with octreotide, long-acting release (Oct-LAR).[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4363460 Wed, 17 Nov 2010 00:00:00 +0100 4363460 http://www.medworm.com/index.php?rid=4176425&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1267244 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1267244AbstractObjective: To assess the efficacy of different dosing intervals of lanreotide, Somatuline Autogel® (Lan-ATG) 120 mg in patients with acromegaly, previously treated with octreotide, long-acting release (Oct-LAR).[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4176425 Wed, 17 Nov 2010 00:00:00 +0100 4176425 http://www.medworm.com/index.php?rid=4176424&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1265133 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1265133AbstractBackground: Several studies have reported that thyrotropin (TSH) levels are slightly increased in obese subjects. On the contrary, other studies have provided no evidence for an association between thyroid status and body mass index (BMI).[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4176424 Wed, 17 Nov 2010 00:00:00 +0100 4176424 http://www.medworm.com/index.php?rid=4176423&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1267918 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1267918AbstractBackground: Neuroendocrine changes are important processes which accompany critical illness, however, the number of clinical studies concentrating on the role of thyroid gland hormones in stroke pathogenesis is relatively small. The aim of this prospective study was to investigate the relation between free triiodothyronine (fT3) levels and the prognosis of patients with stroke.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4176423 Wed, 17 Nov 2010 00:00:00 +0100 4176423 http://www.medworm.com/index.php?rid=4110650&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1267184 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1267184AbstractAim: The aim of the study was to assess the factors that influence carotid intima-media thickness (CIMT) and arterial stiffness in type 1 diabetic patients.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4110650 Wed, 27 Oct 2010 23:00:00 +0100 4110650 http://www.medworm.com/index.php?rid=4110649&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1267239 In this study we quantified the gene expression in vaginal smear of sexually mature cattle in order to observe physiological effects. Further we aimed to establish a new screening method by testing the effect of a combination of certain anabolic steroid hormones on physiological regulations of mRNA expression of selected genes. In an animal trial Nguni heifers were treated with the anabolic combination trenbolone acetate plus estradiol. Vaginal smear samples were taken at 4 different time points. Gene expression of 27 candidate genes, selected by screening the actual literature for steroidal effects on vaginal epithelial cells, were estimated using quantitative real-time RT-PCR. There were different expression changes observed at different time points. It could be shown that the applied an... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4110649 Wed, 27 Oct 2010 23:00:00 +0100 4110649 http://www.medworm.com/index.php?rid=4110648&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1267202 In conclusion, increased food intake is a crucial component in the development of obesity in TallyHo mice, in which central leptin resistance, possibly caused by uncoupling between activation of leptin signaling and neuropeptide expression, might be involved.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4110648 Wed, 27 Oct 2010 23:00:00 +0100 4110648 http://www.medworm.com/index.php?rid=4110647&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1267912 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1267912AbstractObjective: Acromegaly is associated with deleterious comorbidities that can remain irreversible even after successful cure has been achieved and lead to a persistently impaired Quality of Life (QoL). The aim of the study was to assess frequency and degree of persistent comorbidities and complaints after treatment of acromegaly and to investigate their impact on QoL. Another scope of interest was to determine gender-specific factors that influence perceived QoL in men and women.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4110647 Wed, 27 Oct 2010 23:00:00 +0100 4110647 http://www.medworm.com/index.php?rid=4110646&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1265163 This study investigated sex differences in longitudinal changes in blood glucose concentration (BGC) in wolframin-deficient mice (Wfs1KO) and compared their plasma proinsulin and insulin levels with those of wild-type (wt) mice. Non-fasting BGC was measured weekly in 42 (21 males) mice from both groups at nine weeks of age. An intraperitoneal glucose tolerance test (IPGTT) was conducted at the 30th week and plasma insulin, c-peptide and proinsulin levels were measured at the 32nd week. At the 32nd week, Wfs1KO males had increased BGC compared to wt males (9.40±0.60 mmol/l vs. 7.91±0.20 mmol/l; p<0.05). The opposite tendency was seen in females. Both male and female Wfs1KO mice had impaired glucose tolerance on IPGTT. Wfs1KO males had significantly lower mean plasma insulin... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4110646 Wed, 27 Oct 2010 23:00:00 +0100 4110646 http://www.medworm.com/index.php?rid=4110645&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1267235 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1267235AbstractIt is well known, that wound healing in diabetes is impaired. Persistently high levels of matrix-metalloproteases (MMPs) contribute to wound persistence. The topical use of protease-inhibitors might beneficially affect wound healing.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4110645 Wed, 27 Oct 2010 23:00:00 +0100 4110645 http://www.medworm.com/index.php?rid=4110644&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1265174 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1265174AbstractObjective: Vaspin, adiponectin and interleukin-6 (IL-6) constitute novel adipose-tissue derivatives, known as adipokines, which mediate insulin resistance. The aim of the present study was to evaluate the effects of metformin and rosiglitazone on serum levels of those novel adipokines in drug-naïve patients with type 2 diabetes mellitus (T2DM).[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4110644 Wed, 27 Oct 2010 23:00:00 +0100 4110644 http://www.medworm.com/index.php?rid=4110643&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1265213 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1265213AbstractObjectives: To explore the association between depressive symptoms as measured by the Center for Epidemiologic Studies Depression Scale or not completing the questionnaire and subsequent risk of poor compliance with regular visits to primary care physician in patients with type 2 diabetes.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4110643 Wed, 27 Oct 2010 23:00:00 +0100 4110643 http://www.medworm.com/index.php?rid=3944264&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1255105 In this study, we explored whether these RSCs could also be influenced to acquire properties characteristic of the pancreas. To this end, RSCs in culture were exposed to media conditioned by rat islet tumor cells and media containing Exendin-4 and nicotinamide since both have been shown to induce pancreatic phenotypes in embryonic stem cells. Lastly, an expression construct for pdx-1 was introduced into RSCs. The expression of pancreatic markers was analyzed using RT-PRC and immunocytochemistry. When RSCs were exposed to rat islet tumor cell conditioned media and media containing Exendin-4 and nicotinamide, the expression of pdx-1, insulin and somatostatin were observed. They also acquired a spherical shape typical of pancreatic cells in culture. Under these varied conditions, transcriptio... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3944264 Tue, 07 Sep 2010 23:00:00 +0100 3944264 http://www.medworm.com/index.php?rid=3944263&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1263104 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1263104AbstractObjective: The aim of the study was to analyze the time-to-diagnosis interval in patients with Cushing's disease (CD) and acromegaly (AC), to assess factors that promote early disease detection and to investigate the medical fields diagnosing the pathologies.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournal:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3944263 Tue, 07 Sep 2010 23:00:00 +0100 3944263 http://www.medworm.com/index.php?rid=3944262&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1263111 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1263111AbstractAlthough obesity may be linked to resistin, the role of resistin in humans is still controversial. Conflicting results of the associations between resistin and BMI and measures of insulin resistance were reported. In view of the yet unexplained role of resistin in human obesity, the aim of this study was to examine correlations between serum resistin concentrations and the degree of human obesity and insulin sensitivity. For this purpose, we investigated 2 homogenous groups of obese and non obese humans, in whom the presence of obesity was the solely differentiating factor. The WHO definition of obesity was used. Study group consisted of 136 obese subjects (75 women and 61 men) and 48 non-obese controls (31 women, 17 men) aged ... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3944262 Tue, 07 Sep 2010 23:00:00 +0100 3944262 http://www.medworm.com/index.php?rid=3944261&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1262860 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1262860AbstractContext: Thyroid hormone (TH) mediated changes in gene expression were thought to be primarily initiated by the nuclear TH receptor (TR) binding to a thyroid hormone response element in the promoter of target genes. A recently described extranuclear mechanism of TH action consists of the association of TH-liganded TRβ with phosphatidylinositol 3-kinase (PI3K) in the cytosol and subsequent activation of the PI3K pathway.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournal:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3944261 Tue, 07 Sep 2010 23:00:00 +0100 3944261 http://www.medworm.com/index.php?rid=3944260&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1263127 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1263127AbstractBackground: Obesity and diabetes in mice can be modified by dietary variables. Here we systematically analysed the effect of the sucrose and fat content and of the fat quality in New Zealand Obese mice, a mouse model of the metabolic syndrome.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournal:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3944260 Tue, 07 Sep 2010 23:00:00 +0100 3944260 http://www.medworm.com/index.php?rid=3944259&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1263150 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1263150AbstractObjective: Impaired glucose tolerance (IGT) is a predictor of type 2 diabetes in adults. However, the converting rate from IGT to diabetes is largely unknown in obese children.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournal:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3944259 Tue, 07 Sep 2010 23:00:00 +0100 3944259 http://www.medworm.com/index.php?rid=3944258&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1262836 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1262836AbstractObjective: To investigate the efficacy of sorafenib in progressive metastatic Medullary Thyroid Carcinoma (MTC), for which there is currently no effective treatment.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournal:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3944258 Tue, 07 Sep 2010 23:00:00 +0100 3944258 http://www.medworm.com/index.php?rid=4069029&cid=s_36607_15_f&fid=36607&url=https%3A%2F%2Fwww.thieme-connect.com%2Fejournals%2Ftoc%2Feced%2F102973%2Fgrouping%2F102634 Experimental and Clinical Endocrinology & Diabetes 2010; 09Article in Thieme eJournals:Table of contents  |  Congress (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=4069029 Thu, 02 Sep 2010 23:00:00 +0100 4069029 http://www.medworm.com/index.php?rid=3825041&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0030-1262801 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1262801Abstract Low serum Sex Hormone-Binding Globulin (SHBG) has been proposed as an indicator of the Metabolic Syndrome (MS) and cardiovascular disease in men. On the other hand, the (TAAAA)n repeat polymorphism in the gene has been shown to affect SHBG levels. The possible role of this polymorphism in the MS was examined in the present study.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3825041 Fri, 06 Aug 2010 05:39:51 +0100 3825041 http://www.medworm.com/index.php?rid=3825040&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0030-1261934 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1261934Abstract The aim of this prospective study was to evaluate the contribution of the indicator test for sudomotor function Neuropad to the early diagnosis of peripheral neuropathy in patients with type 2 diabetes mellitus. Included were 109 type 2 diabetic patients (55 men, mean age 56.15±6.14 years), whose initial clinical examination (Neuropathy Disability Score, NDS) was negative for neuropathy. Patients were first examined between January and June 2004 and re-examined 5 years later by the NDS and Neuropad. Initially, 70 patients (64.22%) had normal and 39 (35.78%) patients had abnormal Neuropad (groups A and B, respectively). NDS was significantly higher in group B on both examinations (p<0.001). On the second examination, 2 pati... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3825040 Fri, 06 Aug 2010 05:39:51 +0100 3825040 http://www.medworm.com/index.php?rid=3825039&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0030-1262790 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1262790AbstractGhrelin and peptide YY (PYY) are brain-gut peptides that have a variety of physiological functions and are involved in energy regulation. Thus far, abnormalities in the expression and secretion of ghrelin and PYY are known to occur in lifestyle-related diseases, including obesity, and the improvement of these abnormalities has become an important challenge. Exercise has recently been reported to influence ghrelin and PYY concentrations. Exercise increases the PYY secretion. The effects of exercise on ghrelin levels vary with the study subject, timing of exercise, and duration of exercise. Here, we review the findings of recent studies on the association of PYY and ghrelin with obesity, particularly, on the influence of exercise... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3825039 Fri, 06 Aug 2010 05:39:51 +0100 3825039 http://www.medworm.com/index.php?rid=3825038&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0030-1261933 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1261933AbstractIncreasing studies have shown that the patients with diabetes mellitus have an increased risk of cognitive impairment, dementia, and neurodegeneration. The present study was designed to evaluate the effect of aspirin on diabetes-associated learning and memory decline in mice. Diabetes was induced by a single intraperitoneal injection of streptozocin (150 mg/kg body weight) in C57BL/6 mice. The mice were administered with aspirin at a dose of 30 mg/kg by intragastric administration once a day for 1, 4 or 8 weeks respectively. 8 weeks after aspirin or vehicle treatment, the effect of aspirin on diabetes-associated learning and memory decline in mice was investigated by evaluating the mean escape latency and the percen... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3825038 Fri, 06 Aug 2010 05:39:51 +0100 3825038 http://www.medworm.com/index.php?rid=3825037&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0030-1261918 This study was done to assess testosterone deficiency in males with metabolic syndrome (MetS) and the effect of testosterone replacement on insulin resistance and biochemical parameters of this syndrome with hypogonadism. Sixty three males fulfilling the International Diabetes Federation 2005 MetS guidelines as cases and 32 healthy males as controls with the mean age of 35.29±8.16 and 34±6.76 years respectively were enrolled in the study. Fasting blood samples were collected for gonadal profile and insulin assay. Homeostasis model assessment for insulin resistance (HOMA-IR) and free testosterone index were calculated. Hypogonadism was defined when the calculated free testosterone value was <0.225 nmol/L.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGe... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3825037 Fri, 06 Aug 2010 05:39:51 +0100 3825037 http://www.medworm.com/index.php?rid=3825036&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0030-1262815 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1262815Abstract Neuropsychological sequelae are common after aneurysmal subarachnoid hemorrhage (aSAH) and may be associated with or caused by supposed hypothalamic-pituitary dysfunction. We evaluated the incidence of neuro-endocrine and neuropsychological deficits after aSAH and their interrelations in a standardized manner.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3825036 Fri, 06 Aug 2010 05:39:51 +0100 3825036 http://www.medworm.com/index.php?rid=3825035&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0030-1255104 This study evaluated the diagnostic validity of salivary 17OHP for monitoring medical treatment, with samples collected at 7 time points throughout a day.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3825035 Fri, 06 Aug 2010 05:39:51 +0100 3825035 http://www.medworm.com/index.php?rid=3825034&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0030-1262816 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1262816AbstractThe most common cause of Maturity-Onset Diabetes of the Young (MODY) are mutations in the Hepatic Nuclear Factor 1α (HNF-1α) gene, resulting in MODY3. In a family afflicted with diabetes, a novel nonsense mutation in HNF-1α, E41X, causing a termination codon behind the dimerization domain, was found. The penetrance in individuals older than 25 years was 81.8%. The age at manifestation of diabetes ranged from 18 to 63 years, only 2 out of 10 diabetic individuals developed the disease at ages younger than 25 years. Although diabetes duration lasted up to 35 years in this family, only one family member suffered from diabetic complications. Additional polymorphisms in HNF-1α, I27L and S487N, were found in this p... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3825034 Fri, 06 Aug 2010 01:16:52 +0100 3825034 http://www.medworm.com/index.php?rid=3930557&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1262801 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1262801AbstractObjective: Low serum Sex Hormone-Binding Globulin (SHBG) has been proposed as an indicator of the Metabolic Syndrome (MS) and cardiovascular disease in men. On the other hand, the (TAAAA)n repeat polymorphism in the SHBG gene has been shown to affect SHBG levels. The possible role of this polymorphism in the MS was examined in the present study.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournal:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3930557 Wed, 04 Aug 2010 23:00:00 +0100 3930557 http://www.medworm.com/index.php?rid=3930556&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1261934 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1261934AbstractAim: The aim of this prospective study was to evaluate the contribution of the indicator test for sudomotor function Neuropad® to the early diagnosis of peripheral neuropathy in patients with type 2 diabetes mellitus. Included were 109 type 2 diabetic patients (55 men, mean age 56.15±6.14 years), whose initial clinical examination (Neuropathy Disability Score, NDS) was negative for neuropathy. Patients were first examined between January and June 2004 and re-examined 5 years later by the NDS and Neuropad®. Initially, 70 patients (64.22%) had normal and 39 (35.78%) patients had abnormal Neuropad® (groups A and B, respectively). NDS was significantly higher in group B on both examinations (p<0.001). On the second examinati... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3930556 Wed, 04 Aug 2010 23:00:00 +0100 3930556 http://www.medworm.com/index.php?rid=3930555&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1262790 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1262790AbstractGhrelin and peptide YY (PYY) are brain-gut peptides that have a variety of physiological functions and are involved in energy regulation. Thus far, abnormalities in the expression and secretion of ghrelin and PYY are known to occur in lifestyle-related diseases, including obesity, and the improvement of these abnormalities has become an important challenge. Exercise has recently been reported to influence ghrelin and PYY concentrations. Exercise increases the PYY secretion. The effects of exercise on ghrelin levels vary with the study subject, timing of exercise, and duration of exercise. Here, we review the findings of recent studies on the association of PYY and ghrelin with obesity, particularly, on the influence of exercise... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3930555 Wed, 04 Aug 2010 23:00:00 +0100 3930555 http://www.medworm.com/index.php?rid=3930554&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1261933 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1261933AbstractIncreasing studies have shown that the patients with diabetes mellitus have an increased risk of cognitive impairment, dementia, and neurodegeneration. The present study was designed to evaluate the effect of aspirin on diabetes-associated learning and memory decline in mice. Diabetes was induced by a single intraperitoneal injection of streptozocin (150 mg/kg body weight) in C57BL/6 mice. The mice were administered with aspirin at a dose of 30 mg/kg by intragastric administration once a day for 1, 4 or 8 weeks respectively. 8 weeks after aspirin or vehicle treatment, the effect of aspirin on diabetes-associated learning and memory decline in mice was investigated by evaluating the mean escape latency and the percen... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3930554 Wed, 04 Aug 2010 23:00:00 +0100 3930554