MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Experimental and Clinical Endocrinology and Diabetes' source. Sun, 14 Mar 2010 14:14:06 +0100 http://www.medworm.com/index.php?rid=3344124&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0030-1248288 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1248288AbstractMetabolic syndrome (MetS) is rapidly growing into one of the major public health issues worldwide. Interleukin 1 receptor antagonist (IL1Ra) functions as a competitor of proinflammatory cytokines and has an important role in metabolic functions, including insulin secretion. To identify the relationship between the interleukin 1 receptor antagonist gene and MetS, we genotyped nine single nucleotide polymorphisms (SNPs) in the gene using direct sequencing in 66 MetS patients and 346 normal subjects in the Korean population. Among the nine polymorphisms, after adjusting for age and sex, rs928940 (G>T) showed a significant association with MetS in the codominant ( 0.023) and recessive models ( 0.011). Also, rs315952 (C>T) exh... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3344124 Tue, 09 Mar 2010 14:27:37 +0100 3344124 http://www.medworm.com/index.php?rid=3344123&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1224122 The objective of the present study was to determine the effects of acute treatment (AT) with acetone on the oxidative and metabolic status of rats. The AT group (n=16) was treated by gavage with a single administration of 7.0 g acetone/kg body weight at a concentration of 25% (m/v). Eight rats were euthanized 6 h later (AT6) and eight 24 h later (AT24). Acetone levels were determined in blood and urine and oxidative parameters were analyzed by determining thiobarbituric acid reactive species (TBARS, indicators of lipid peroxidation) and reduced glutathione (GSH) and vitamin E as antioxidant parameters. Serum glucose, blood cholesterol and triglycerieds and hepatic fat were also determined. The results indicated a significant difference in the hepatic oxidative parameters,... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3344123 Tue, 09 Mar 2010 14:27:37 +0100 3344123 http://www.medworm.com/index.php?rid=3344122&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1224123 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1224123AbstractA 57 yr old man presented to endocrinology clinic with a six year history of poorly controlled hypertension which was treated with Metoprolol 200 mg/day and Enalapril 20 mg/day. He was asymptomatic but incidentally hypokalaemia was detected while having cholecystectomy, two years prior to his clinic appointment. He had never been on diuretics or laxatives. He was started on potassium supplements (120 mmol/d) and advised to increase dietary potassium by the surgical team. A detailed personal history revealed ingestion of 300–500 g licorice per day. Physical examination was unremarkable apart from increased blood pressure of 180/105 mmHg. Following the initial visit, his serum electrolyes (K+3.... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3344122 Tue, 09 Mar 2010 14:27:37 +0100 3344122 http://www.medworm.com/index.php?rid=3344121&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0030-1249084 In conclusion, low-dose alendronate induced mineralization in mouse osteoblastic cells. The regulation of PC-1, osteocalcin and ALP by alendronate might play some role in these effects.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3344121 Tue, 09 Mar 2010 03:31:45 +0100 3344121 http://www.medworm.com/index.php?rid=3328626&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0030-1248325 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1248325AbstractDiabetes is frequently associated with declining sexual function resulting from oxidative damage. NADPH oxidase is a major resource of reactive oxygen species (ROS) in the testes and is likely related to an activated endothelin-1 (ET-1) system. An activation of NADPH oxidase - ET-1 pathway was hypothesized in diabetic testopathy. We verified the hypothesis and tested if strontium fructose 1,6-diphosphate (FDP-Sr) could relieve these changes in diabetic testis as compared to testosterone propionate (TP) and sildenafil. Diabetes was produced in male Sprague-Dawley rats 8 weeks after a single injection of streptozotocin (STZ), and interventions with testosterone propionate (TP), sildenafil and FDP-Sr were conducted in the last 4 w... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3328626 Thu, 04 Mar 2010 14:23:38 +0100 3328626 http://www.medworm.com/index.php?rid=3328625&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0030-1249024 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1249024AbstractGlycemic and body weight control are two outstanding goals in the treatment of patients with type 2 diabetes that often are not appropriately achieved. This observational study evaluates whether treatment by quality controlled diabetes centers generates an improvement in this regard and focuses on associations with different therapies. Data of 9.294 type 2 diabetic patients (mean age 66.9±11.6 years, mean diabetes duration 12.4±9.2 years) from 103 German diabetes centers were assessed by a standardized, prospective, computer-based diabetes care and outcome documentation system (DPV-Wiss-database). Therapeutic concepts included lifestyle intervention (n=1.813), oral antidiabetics (OAD, n=1.536), insulin (n=4.504) and insulin p... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3328625 Thu, 04 Mar 2010 14:23:38 +0100 3328625 http://www.medworm.com/index.php?rid=3328624&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0030-1248289 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1248289AbstractTopiramate is an anticonvulsant agent effective in the prophylaxis of migraine, which also induces weight reduction by an unknown mechanism. We investigated the effect of topiramate on metabolic and endocrine parameters in patients with migraine independently of any intention to lose body weight. Six patients (26–61 years old, body mass indices [BMI] 20.9–32.1 kg/m) with migraine were treated with an average dose of 100 mg topiramate/day over a period of 20 weeks. The following parameters were measured every 4–8 weeks: BMI, body fat proportion, waist and hip circumference, HOMA insulin resistance, fasting serum-/plasma concentrations of adiponectin, leptin, ghrelin, vascular endothelial growth fact... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3328624 Thu, 04 Mar 2010 14:23:38 +0100 3328624 http://www.medworm.com/index.php?rid=3328623&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0030-1249006 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1249006Abstract Estrogens play an important role in male physiology. We investigated the possible association of four single nucleotide polymorphisms in Estrogen Receptor α () and Estrogen Receptor β () genes with circulating levels of sex steroids and Sex Hormone Binding Globulin (SHBG) in men.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3328623 Thu, 04 Mar 2010 14:23:38 +0100 3328623 http://www.medworm.com/index.php?rid=3328622&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0030-1247516 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1247516Abstract Triple A syndrome, also known as Allgrove syndrome, is a rare autosomal recessive disorder characterized by three cardinal symptoms: adrenal insufficiency due to ACTH insensitivity, achalasia and alacrima. Various progressive neurological abnormalities and skin changes have been described in association with the syndrome. The disease is caused by mutation in the gene on chromosome 12q13. encodes a protein named ALADIN which is part of the nuclear pore complex (NPC). The mislocalization of mutated ALADIN proteins in the cytoplasm and/or the nucleus results in an impaired protein function. Phenotypes of previously reported patients with triple A syndrome varied within and between affected families so that no genotype-phenotype c... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3328622 Thu, 04 Mar 2010 14:23:38 +0100 3328622 http://www.medworm.com/index.php?rid=3328621&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0030-1247565 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1247565Abstract The global spread of diabetes (DM) and the importance of early therapeutic intervention determine the need of simple, inexpensive and sensitive methods for diagnosis of diabetic complications in the general practice. The aim of this study was to assess a new instrument – the plaster Neuropad in diagnosing the sudomotor diabetic dysfunction and to investigate the correlates of Neuropad data with diabetic complications.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3328621 Thu, 04 Mar 2010 14:23:38 +0100 3328621 http://www.medworm.com/index.php?rid=3328620&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0030-1248290 The objective of the present study was to examine the effect of acute, methionine-induced hyperhomocysteinemia (HHCY) on endothelial function and indices of arterial stiffness in subjects with type 2 diabetes mellitus (T2DM). A total of 30 subjects with T2DM, free of macrovascular disease were examined in a crossover study. L-methionine (M) (0.1 g/kg) and water (W) load were given in random order with an interval of about 1 week in between. Endothelial function was assessed by flow-mediated vasodilation (FMD). Arterial stiffness was assessed by determination of augmentation index (AI). Measurements were performed in the fasting state, 1, 2 and 3 h after the M or the W load. Total plasma homocysteine (HCY) levels did not change after W administration, while M administration resu... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3328620 Thu, 04 Mar 2010 03:16:23 +0100 3328620 http://www.medworm.com/index.php?rid=3324245&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1225351 We report a case of a 58-year-old woman who complained of progressive hirsutism, nervousness, irritability, anxiousness and an increased libido. Examination showed an unusual redness of her head, décolleté, palms and soles of her feet. Basal laboratory tests revealed a profound elevation of testosterone levels (7.5 μg/l) and normal levels of androstendione, dehydroepiandrosterone-sulfate, 17α-hydroxy-progesterone and thyroid-stimulating hormone. Also remarkable was that her red blood count, hemoglobin and hematocrit values were elevated while erythropoietin was within normal limits. Functional laboratory tests ruled out heterozygous C21-hydroxylase deficiency and showed a moderate insulin resistance on the oral glucose tolerance test. Transvaginal ultrasound revealed a sl... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3324245 Wed, 03 Mar 2010 14:22:41 +0100 3324245 http://www.medworm.com/index.php?rid=3324244&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0030-1248309 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1248309AbstractTreatment of congenital adrenal hyperplasia (CAH) in its salt-wasting form with appropriate doses of glucocorticoids and mineralocorticoids should promote growth, puberty and final height in a similar to normal pattern. However, the individual requirements for these drugs to normalize the hormonal profile and to achieve a physiologic growth pattern may differ. Moreover, the time of onset of puberty is also unpredictable since the course of the disease may predispose for precocity. The aim of this study was to explain the unexpected arrest of growth during puberty in a boy with late-onset CAH, who had been treated with glucocorticoid from early childhood. A short course of GnRH agonist treatment was also introduced in later year... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3324244 Wed, 03 Mar 2010 14:22:41 +0100 3324244 http://www.medworm.com/index.php?rid=3324243&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0030-1249007 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1249007AbstractAnimal studies have previously shown that activin A enhances osteoblast proliferation and increases bone formation and bone mechanical strength . For the further understanding of its action in human osteoblast, we studied the pattern of a cell cycle response to the treatment with activin A. We hypothesize that activin A alters the cell cycle pattern of human osteoblast. Primary cultures of human osteoblast-like cells were treated by activin A in a biologically effective concentration (100 ng/mL). The cells in cultured samples were counted, assayed for cellular alkaline phosphatase activity and calcitonin expression, LDH activity in the medium, cellular BrdU incorporation, cell cycle cytometry and compared to untreated con... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3324243 Wed, 03 Mar 2010 14:22:41 +0100 3324243 http://www.medworm.com/index.php?rid=3324242&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0030-1249014 In conclusion, our data demonstrate, that expressions of DPP-4 and attractin in circulating blood monocytes of human subjects are influenced by metabolic abnormalities with obesity being an important factor.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3324242 Wed, 03 Mar 2010 14:22:41 +0100 3324242 http://www.medworm.com/index.php?rid=3324241&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0030-1247566 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1247566AbstractType-1 diabetes (T1D) is a metabolic disorder associated with massive reduction in mass of adipose tissue. Measuring cell diameter, an index of fat metabolism, we determined depot-specific alterations in weight of adipose tissue, fat cell diameter and size heterogeneity and distribution at 5 depots in streptozotocin (STZ)-induced diabetic rats. T1D was induced by a single injection of STZ. Seven days after the injection, fat depots were isolated, weighted, washed and maintained in tissue culture medium. Using a microscope equipped with calibrated micrometer, cell diameter as well as size distribution pattern and heterogeneity of adipocytes were determined in fresh tissue slices of subcutaneous (SC), proximal epididymal (PE), di... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3324241 Wed, 03 Mar 2010 14:22:41 +0100 3324241 http://www.medworm.com/index.php?rid=3324240&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1224153 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1224153AbstractOMC (octyl-methoxycinnamate), an endocrine disruptor having estrogenic activity, is used in sunscreen creams as UV filter. We studied its “in vitro” effects on the hypothalamic release of Gn-RH as well as on the amino acid neurotransmitter system. OMC significantly decreased Gn-RH release in normal male and female rats as well as in castrated rats with substitutive therapy. No effects were observed in castrated rats without substitutive therapy. In males OMC increases the release of GABA, decreasing the production of glutamate (GLU) while in the female decreases the excitatory amino acid aspartate (ASP) and GLU without modifications in the hypothalamic GABA release. These results suggest that OMC acting as endocrine... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3324240 Wed, 03 Mar 2010 03:15:47 +0100 3324240 http://www.medworm.com/index.php?rid=3313049&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1225614 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1225614AbstractTransforming growth factor beta 1 (TGFB1) stimulates the production of various extracellular matrix components; at the same time, it inhibits matrix degradation. These actions of TGFB1 contribute to tissue repair, however, an altered expression of TGFB1 can be a causative factor of fibrosis processes, including thyroid fibrosis which follows chronic thyroiditis. The aim of our study was to examine a potential correlation between TGFB1 gene expression level in fine-needle aspiration biopsy (FNAB) thyroid specimens and fibrosis of the thyroid gland in two types of thyroid lesions. Fibrosis of the thyroid tissue was assessed, based on the expression levels of fibrosis-associated genes ( and ) in thyroid FNAB samples, on the FNAB s... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3313049 Sat, 27 Feb 2010 03:12:46 +0100 3313049 http://www.medworm.com/index.php?rid=3308560&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0030-1247544 In this study we investigated the effect of moderate increases in dietary fat (10–30% of fat as total calories) and associated differences in fatty acid content, on the development of metabolic perturbations in the Wistar rat.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3308560 Fri, 26 Feb 2010 03:11:46 +0100 3308560 http://www.medworm.com/index.php?rid=3299726&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1238313 Exp Clin Endocrinol Diabetes 2010; 118: 87-92DOI: 10.1055/s-0029-1238313Abstract We studied the effect of an oral glucose load on circulating ghrelin, as well as ghrelin and ghrelin receptor (GHS-R1a) mRNA expression in subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT) and placental tissue from pregnant women with gestational diabetes (GDM) and normal glucose tolerance (NGT).[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3299726 Wed, 24 Feb 2010 14:23:39 +0100 3299726 http://www.medworm.com/index.php?rid=3277487&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1243634 We report a rare case of an ileal endocrine carcinoma that produced ACTH and induced hypercortisolism. A now 47-year-old man presented at age 41 with weight gain, tremor, perspiration, and general fatigue. Laboratory testing showed hypercortisolism and diabetes mellitus. Further examinations revealed ectopic Cushing's syndrome. The search for the primary tumor was difficult. The patient underwent subtotal thyroidectomy and surgical removal of a pituitary lesion. After resection of an ACTH-producing metastasis of the mesentery, temporary remission of Cushing's syndrome ensued. At the age 45 the primary tumor was detected in the ileum by Ga-68 DOTATOC-PET scan and explorative laparotomy. After surgical removal of this well differentiated neuroendocrine carcinoma the patient significantly imp... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3277487 Wed, 17 Feb 2010 14:18:36 +0100 3277487 http://www.medworm.com/index.php?rid=3277486&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0028-1087179 We report two cases of sarcoidosis following Cushing's syndrome. A 43 year-old male developed cutaneous sarcoidosis and mediastinal lymphadenopathy after resection of an ACTH-secreting pituitary microadenoma. A 32 year-old female showed cutaneous sarcoidosis, arthralgia, mediastinal lymphadenopathy and elevation of angiotensin-converting enzyme and interleukin 2-receptor concentrations after traumatic adrenal bleeding, which ceased formerly undiagnosed hypercortisolism caused by an adrenal adenoma. Sarcoidosis seems to be a rare sequel following the treatment of hypercortisolism. Skin affections were present and suggestive for the diagnosis in all reported cases. As some cases are probably missed when skin affections are lacking, a more frequent evaluation of patients after Cushing's syndr... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3277486 Wed, 17 Feb 2010 14:18:36 +0100 3277486 http://www.medworm.com/index.php?rid=3277485&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0030-1247543 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1247543Abstract Insulin induces electrochemical alterations in sheep visceral and parietal pleura, an effect abolished by the Na-channel blocker amiloride and the Na-K pump inhibitor ouabain. The aim of this study was to further investigate the role of different electrolytes and glucose in these electrochemical changes.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3277485 Wed, 17 Feb 2010 14:18:36 +0100 3277485 http://www.medworm.com/index.php?rid=3277484&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1241876 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1241876Abstract Women who develop diabetes during pregnancy are at significant risk of developing Type 2 diabetes later in life, and “should be offered blood glucose testing … to exclude persisting hyperglycaemia” after delivery. New UK guidelines now recommend that this is done by measurement of fasting blood glucose, rather than an oral glucose tolerance test (OGTT). Our study aims to establish whether assessment by fasting blood glucose gives equivalent results to an OGTT.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3277484 Wed, 17 Feb 2010 14:18:36 +0100 3277484 http://www.medworm.com/index.php?rid=3277483&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1237702 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1237702Abstract Many studies showed that impairment of flow-mediated endothelium-dependent arterial dilation (FMD) exists in patients with subclinical hypothyroidism (sHT). The crucial mechanism of this endothelial dysfunction remain unclear. We hypothesized that oxidative stress may be partially responsible for the impairment in FMD in patients with sHT. Thus, the present study was designed to assess whether the antioxidant alpha-lipoic acid can improve endothelial dysfunction in patients with sHT.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3277483 Wed, 17 Feb 2010 03:27:30 +0100 3277483 http://www.medworm.com/index.php?rid=3256421&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0028-1103275 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0028-1103275AbstractA 7-year-old boy with severe rickets that by clinical analysis was diagnosed as affected by type II vitamin D-dependent rickets, was evaluated for mutations in the vitamin D receptor gene (VDR). The molecular analysis showed a homozygous state for a novel missense mutation (C84R) in a highly conserved nucleotide in the second Zn finger of the DNA binding domain.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3256421 Wed, 10 Feb 2010 14:14:11 +0100 3256421 http://www.medworm.com/index.php?rid=3256420&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1237698 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1237698Abstract Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease and extrarenal manifestations may be observed in many organ systems. Hypothalamus-pituitary-adrenal axis was not evaluated extensively in patients with ADPKD. We aimed to evaluate this axis in these patients.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3256420 Wed, 10 Feb 2010 14:14:11 +0100 3256420 http://www.medworm.com/index.php?rid=3256419&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1243605 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1243605Abstract Hypopituitarism with adult-onset growth hormone deficiency (GHD) is associated with increased cardiovascular morbidity and mortality due to premature and progressive atherosclerosis. An underlying cause of atherosclerosis is increased insulin resistance. Elevated fasting and postprandial glucose and lipid levels may contribute to premature atherosclerosis. We studied effects of growth hormone replacement (GHRT) on fasting and postprandial metabolic parameters as well as on insulin sensitivity in patients with adult-onset GHD.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3256419 Wed, 10 Feb 2010 14:14:11 +0100 3256419 http://www.medworm.com/index.php?rid=3256418&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1220770 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1220770AbstractPolycystic ovary syndrome (PCOS) is associated with hyperandrogenism, insulin resistance (IR), and chronic inflammation. Simvastatin improves endocrine/clinical aspects of PCOS and decreases systemic inflammation in PCOS. There have been no comparative studies carried out regarding the effects of different statin treatment in PCOS. We aimed to assess the effects of two different statin treatments on various metabolic, endocrine, oxidative and inflammatory factors in PCOS.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3256418 Wed, 10 Feb 2010 14:14:11 +0100 3256418 http://www.medworm.com/index.php?rid=3256417&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1225613 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1225613AbstractRecently, two single nucleotide polymorphisms, rs4355801 near the osteoprotegerin (OPG) gene and rs3736228 in the low-density lipoprotein receptor-related protein 5 (LRP5) gene, were found to be associated with osteoporosis and osteoporotic fractures in Caucasians in a genome wide association study. In the present study, we investigated the association between these two SNPs (rs4355801 and rs3736228) and bone mass density (BMD), whole body T score and metabolic phenotypes (e. g., body mass index, glucose, triglyceride, and total cholesterol) in 425 Chinese Han subjects. We observed a significant association between rs3736228 in LRP5 and hip BMD, total BMD, and T score. The level of hip BMD, total BMD, and T score was sign... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3256417 Wed, 10 Feb 2010 14:14:11 +0100 3256417 http://www.medworm.com/index.php?rid=3256416&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1215586 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1215586Abstract Multidrug resistance 1 gene is responsible for the resistance of a large variety of drugs in human cells. We tried to evaluate this in the present study in thyroid stimulant hormone receptor antibody positive subjects.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3256416 Wed, 10 Feb 2010 02:51:30 +0100 3256416 http://www.medworm.com/index.php?rid=3245295&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1243234 Exp Clin Endocrinol Diabetes 2010; 118: 68-68DOI: 10.1055/s-0029-1243234© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3245295 Sat, 06 Feb 2010 14:19:34 +0100 3245295 http://www.medworm.com/index.php?rid=3245294&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1243193 Exp Clin Endocrinol Diabetes 2010; 118: 4-8DOI: 10.1055/s-0029-1243193AbstractEpidemiological findings have shown up to two-fold increases in the risks of cancers of the colorectum, breast, endometrium, kidney (renal cell tumours), liver and pancreas among diabetes patients. In the present review, we address the question whether, on the basis of these epidemiological observations, type 2 diabetes should be considered a specific and independent risk factor for these various forms of cancer, due to its particular metabolic characteristics of glucose intolerance and hyperinsulinemia. On the basis of further epidemiological evidence among non-diabetic individuals, as well as recent studies examining the effects of different types of diabetes treatment on cancer risks, we conclude that chronic ... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3245294 Sat, 06 Feb 2010 14:19:34 +0100 3245294 http://www.medworm.com/index.php?rid=3245293&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1246117 Exp Clin Endocrinol Diabetes 2010; 118: 1-3DOI: 10.1055/s-0029-1246117AbstractRecently published data examining the role of the metabolic syndrome and obesity in cardiovascular disease rendered suprising results. In addition, other studies revealed that there is more to diabetes therapy than lowering blood glucose, which might under certain circumstances even harm patients. In the light that we now know that “death” is as important an endpoint in diabetes as in other diseases, new tools – better than the oral glucose tolerance test – are required to identify the patients at risk, as are additional standards in individualized therapy. A critical view on old concepts is necessary.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:T... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3245293 Sat, 06 Feb 2010 14:19:34 +0100 3245293 http://www.medworm.com/index.php?rid=3245292&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1243623 Conclusions: In type 2 diabetic subjects, glycaemic control shows a significant correlation with well-being, while neuropathic pain is associated with lower well-being score.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3245292 Sat, 06 Feb 2010 14:19:34 +0100 3245292 http://www.medworm.com/index.php?rid=3245291&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1246213 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1246213Abstract To determine the prevalence of genetic risk markers of type 1 diabetes (T1D) in children diagnosed at a single centre in Germany and to assess their relation to diabetes-associated autoantibodies.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3245291 Sat, 06 Feb 2010 14:19:34 +0100 3245291 http://www.medworm.com/index.php?rid=3245290&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1243603 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1243603AbstractConvincing epidemiological evidence exists for a causal relationship between increased risk of cancer development and progression and type 2 diabetes mellitus as well as obesity. Though the underlying mechanisms remain elusive, in light of the well-described mitogenic actions of insulin, hyperinsulinaemia in the presence of insulin resistance is probably a key factor. In this short review, an overview over the insulin signalling cascade is given paying special attention to the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI 3-K)/mammalian target of rapamycin (mTOR) pathways which are involved in protein synthesis and cell growth.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New ... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3245290 Sat, 06 Feb 2010 14:19:34 +0100 3245290 http://www.medworm.com/index.php?rid=3245289&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0030-1249005 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1249005© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  FREE: Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3245289 Sat, 06 Feb 2010 14:19:34 +0100 3245289 http://www.medworm.com/index.php?rid=3245288&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1243604 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1243604Abstract Cytochrome P450 (CYP) 2J2 is a regulatory enzyme in the biosynthesis of biologically active -epoxyeicosatrienoic acids (EETs). EETs have been suggested to modulate PPAR-γ and PPAR-α transcription activity and play a role in stimulus-secretion coupling in pancreatic beta cells. Genetic abnormalities in the expression of CYP2J enzymes may play a role in the pathogenesis of type 2 diabetes mellitus (T2DM). Our objective was to investigate G-50T polymorphism (rs890293) in association with insulin resistance markers and T2DM in a Chinese population.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical ... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3245288 Sat, 06 Feb 2010 14:19:34 +0100 3245288 http://www.medworm.com/index.php?rid=3245287&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1246215 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1246215Abstract Our main objective in this study was to identify the type of clinical care received by young type 1 diabetic patients who have made the transition from paediatric to adult care, and to assess the metabolic status of long-term treatment after the transition.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3245287 Sat, 06 Feb 2010 14:19:34 +0100 3245287 http://www.medworm.com/index.php?rid=3245286&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1246216 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1246216AbstractThe aim of this study was to estimate the contribution by type 2 diabetic patients in a low-income country from their own income in attempting to control the disease and to prevent chronic diabetes complications through good glycaemic control. Socio-economic and demographic data for study subjects were obtained from 822 adult diabetic patients attending public or private diabetic clinics in Khartoum State, Sudan. The average annual income of diabetic patients was estimated as USD 1.923. The direct cost of diabetes control was USD 175 per year. This included cost of drugs and ambulatory care, although drug supply was insufficient for 52% of the patients. Glycosylated hemoglobin as a measure of glycaemic control was determined to... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3245286 Sat, 06 Feb 2010 02:46:19 +0100 3245286 http://www.medworm.com/index.php?rid=3221791&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1241825 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1241825Abstract In clinical islet transplantation, inflammatory responses initiated by the transplanted islets and by the host immune system cause acute and chronic graft loss. The resolution of acute inflammation is an active process mediated by specific signals and mediators such as resolvin E1 (RvE1). We investigated the effect of RvE1 on i) the inflammatory status of human pancreatic islets, ii) islet viability and apoptosis, and iii) the instant blood-mediated inflammatory reaction (IBMIR) .[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3221791 Sat, 30 Jan 2010 02:55:50 +0100 3221791 http://www.medworm.com/index.php?rid=3218305&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1241198 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1241198AbstractThe Receptor for Advanced Glycation End-products (RAGE) belongs to the family of pattern-recognition receptors and is significantly involved in the molecular mechanisms mediating pro-inflammatory action of hyperglycemia in diabetes. The aim of the current study was to elucidate the possible functional impact of the genetic variability in the gene constituting previously identified risk haplotype for diabetic nephropathy (−429C/-374T/2184G) by testing the haplotype-specific effect on the gene transcriptional activity . Promotor and intron 8 constructs carrying respective substitutions were amplified and cloned into pGL3-Basic reporter vector and subsequently used for transfection of HEK293 cells. Following 48hrs incubation... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3218305 Fri, 29 Jan 2010 14:11:41 +0100 3218305 http://www.medworm.com/index.php?rid=3218304&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1241826 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1241826Abstract Decrease of hemoglobin occurs in diabetic patients with nephropathy earlier than in nondiabetic patients, probably due to impaired synthesis of erythropoietin (EPO). Apart from EPO, insulin also stimulates erythropoiesis. We investigate whether there are differences between human insulin and insulin analogs in respect of their erythropoiesis stimulating effect.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3218304 Fri, 29 Jan 2010 02:54:43 +0100 3218304 http://www.medworm.com/index.php?rid=3209910&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0030-1247517 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1247517AbstractOsteoporotic vertebral fractures and pathological vertebral lesions are frequent clinical situations causing severe back pain. The pharmacological treatment of the underlying disease and the analgetic treatment of the associated back pain usually do not rid the patient's back pain completely and are insufficient to prevent the fracture-weakened vertebral body from further fracturing with long term consequences for the biomechanical competence of the entire spine. In the last 10 years the minimal invasive treatment options vertebroplasty (VP) and balloon kyphoplasty (BK) have spread quickly because these procedures appeared to be promising treatments to stop the fracture and vertebral lesion associated back pain and to internall... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3209910 Wed, 27 Jan 2010 03:15:45 +0100 3209910 http://www.medworm.com/index.php?rid=3190898&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1241199 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1241199Abstract Basal insulin dose requirements in patients with type 1 diabetes may be derived from the course of glucose concentrations in the fasting state; i. e. by skipping meals. The present study examined whether fasting tests could be replaced by carbohydrate-free meals.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3190898 Thu, 21 Jan 2010 14:14:59 +0100 3190898 http://www.medworm.com/index.php?rid=3190897&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1243230 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1243230Abstract To compare the glycemic variability of insulin detemir and insulin glargine in type 1 and type 2 diabetic patients.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3190897 Thu, 21 Jan 2010 14:14:59 +0100 3190897 http://www.medworm.com/index.php?rid=3190896&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1241215 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1241215Abstract Subjects with type 2 diabetes mellitus (T2DM) have increased morbidity and mortality mainly due to macrovascular complications. In addition, diabetic patients show increased in-hospital admissions in comparison with nondiabetic patients. However, in-hospital mortality data for patients with T2DM are not available in our country. The aim of the present study was to examine mortality rates in diabetic compared to nondiabetic patients admitted to a tertiary hospital during a 10-year period (1998–2007).[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3190896 Thu, 21 Jan 2010 14:14:59 +0100 3190896 http://www.medworm.com/index.php?rid=3190895&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1239519 This study suggests that measurement of postprandial blood glucose during MHD identifies patients who develop PTDM after kidney transplantation. It should be used for screening of patients at risk.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3190895 Thu, 21 Jan 2010 14:14:59 +0100 3190895 http://www.medworm.com/index.php?rid=3190894&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1241823 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1241823Abstract Evidence is mounting that hypoglycaemia among elderly diabetic patients is a very real and costly concern. Objective of this study was to determine the incidence and risk factors for developing severe hypoglycaemia leading to hospital admission, among type 2 diabetic subjects aged 80 years or older.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3190894 Thu, 21 Jan 2010 14:14:59 +0100 3190894 http://www.medworm.com/index.php?rid=3190893&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0030-1248125 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1248125© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  FREE: Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3190893 Thu, 21 Jan 2010 02:58:22 +0100 3190893 http://www.medworm.com/index.php?rid=3080698&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1241203 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1241203AbstractObesity is a multifactorial disorder influenced by genetic, behavioral, environmental and cultural factors. A twelve month old male patient was admitted to the hospital because of malaise, irritability, disquietness and obesity. His BMI was 19.8 kg/m and BMI SDS was 1.38. Mental development was normal, and motor skills were mildly delayed most probably due to his obesity. His physical examination was totally normal except obesity and red hair. A history of hypoglycemia on the fourth day of life, which resolved after oral glucose administration, was reported. The child had been hyperphagic from the first weeks of life and had aggressive behavior when food was denied. The body weight of the patient increased dramatically du... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3080698 Sat, 12 Dec 2009 14:06:48 +0100 3080698 http://www.medworm.com/index.php?rid=3080697&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1237699 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1237699AbstractTesting for pheochromocytoma becomes more frequent in clinical practice. False positive test results may cause patient anxiety and unnecessary imaging studies. The data on false positive results for pheochromocytoma in routine clinical practice are lacking. To examine the prevalence of false positive results and to reveal the clinical features and laboratory tests of patients with markedly elevated but false positive test results, a database of tests for pheochromocytoma at a large general hospital between 2000 and 2008 was reviewed. Of 1 896 patients tested, 417 (22.0%) had at least one abnormal test result and 66 (3.5%) had markedly elevated results. 24 patients with markedly elevated but false positive results received... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3080697 Sat, 12 Dec 2009 14:06:48 +0100 3080697 http://www.medworm.com/index.php?rid=3080696&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1237703 In conclusion, GA treatment showed a decrease in the HOMA-IR and both 11 βHSD1 and 2 activities in all tissues, with more profound decrease in the 48-h treated rats.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3080696 Sat, 12 Dec 2009 14:06:48 +0100 3080696 http://www.medworm.com/index.php?rid=3080695&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1237700 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1237700AbstractFew papers have shown that a hypoechoic appearance of the thyroid gland at ultrasonography (US) is related to a hypofunction and serum positivity of thyroid antibodies (T-Ab). However, it is not ascertained if normal thyroid appearance at US correspond to normal thyroid laboratory tests. The aim of this study was to assess the value of normal thyroid at US in predicting normal thyroid hormones and negative T-Ab in a cohort of 48 adult patients. All patients (37 females and 11 males) were referred to our hospital to undergo their first thyroid US examination, followed by a thyroid function evaluation. All subjects had normal thyroid gland at US. As a control group 65 patients with hypoechoic and inhomogeneous thyroid gland were ... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3080695 Sat, 12 Dec 2009 14:06:48 +0100 3080695 http://www.medworm.com/index.php?rid=3080694&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1224124 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1224124AbstractInsulin-like growth factor-I (IGF-I) is a well documented bone-active growth factor. Clinical studies reported that circulating hormones may affect serum IGF-I levels, with potential consequences on bone remodeling. However, no data on bone matrix concentrations of IGF-I in subjects with endocrine dysfunction is available in humans. Bone mineral density and cancellous bone matrix IGF-I levels were assessed in iliac crest biopsies from 38 patients with low bone mass related to glucocorticoid- (n=10), parathyroid- (n=14) or thyroid (n=14) hormones excess. Results were compared to those of sex- and age-matched patients with primary osteoporosis. Bone matrix extraction was performed based on a guanidine-chlorhidric acid/ethylendiam... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3080694 Sat, 12 Dec 2009 14:06:48 +0100 3080694 http://www.medworm.com/index.php?rid=3080693&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1237705 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1237705Abstract The aim of this study was to evaluate long-term changes in endocrine and metabolic parameters and body mass index in women with polycystic ovary syndrome (PCOS) who were treated with metformin over 2 years without caloric restriction.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3080693 Sat, 12 Dec 2009 14:06:48 +0100 3080693 http://www.medworm.com/index.php?rid=3080692&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1238314 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1238314Abstract Recent regional and germanwide investigations have shown that the abolition of the requirement to declare iodine in foodstuffs and the greater emphasis on information about goitre prevention led to an increase in urinary iodine excretion in German schoolchildren. There was also a decrease in thyroid size and goitre prevalence in children. No up to date results in adults for the whole of Germany are available.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3080692 Sat, 12 Dec 2009 14:06:48 +0100 3080692 http://www.medworm.com/index.php?rid=3080691&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1241206 In conclusion, this study confirms the association of the C(−1260)A polymorphism with AAD, whereas the contribution of G7146A seems less likely.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3080691 Sat, 12 Dec 2009 14:06:48 +0100 3080691 http://www.medworm.com/index.php?rid=3080690&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1241204 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1241204AbstractSerum thyroglobulin levels measurement after injection of recombinant human thyrotropin (rh-TSH) represents the most important advance in the follow-up of patients with differentiated thyroid cancer, obtaining TSH elevation without L-thyroxine withdrawal, avoiding marked hypothyroidism symptoms. During a 4-yr period (2004–2008), 66 consecutive patients with DTC (59 papillary and 7 follicular carcinomas) were examined after rh-TSH Tg test and neck ultrasonography. In all patients basal Tg was <0.25 ng/ml. In twelve (18.5%) examined patients rh-TSH Tg was >0.25 ng/ml, and in seven (58.3%) of these was demonstrated persistent or recurrent disease. These data indicate that rhTSH-Tg>0.25 ng/ml should... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3080690 Sat, 12 Dec 2009 14:06:48 +0100 3080690 http://www.medworm.com/index.php?rid=3080689&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1241207 We report on the first 18 consecutive cases with intraoperative use of a new device for direct contact high-frequency-ultrasound in patients with Cushing's disease.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3080689 Sat, 12 Dec 2009 14:06:48 +0100 3080689 http://www.medworm.com/index.php?rid=3080688&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1241851 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1241851AbstractClinical studies are needed to classify rare and novel RET mutations associated with hereditary medullary thyroid carcinoma (MTC) into one of the clinical risk groups. Here we describe two new RET mutations/variants, R770Q and L881V, in patients with MTC and analyzed genotype-phenotype correlations associated with these RET mutations in the gene carriers.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3080688 Sat, 12 Dec 2009 14:06:48 +0100 3080688 http://www.medworm.com/index.php?rid=3080687&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1237697 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1237697Abstract To explore the effects of long-term exposure to more than adequate and excessive iodine on the apoptosis of thyrocytes in Wistar rats.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3080687 Sat, 12 Dec 2009 14:06:48 +0100 3080687 http://www.medworm.com/index.php?rid=3080686&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1241205 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1241205Abstract The presence and the importance of FasL (FasL, APO-1L/CD95L) in papillary microcarcinoma lesions which are smaller than 1.5 cm of the thyroid is unclear.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3080686 Sat, 12 Dec 2009 03:11:54 +0100 3080686 http://www.medworm.com/index.php?rid=3005730&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1202793 This study aims to determine the fructose concentration and correlate with antioxidant status in senile diabetic and non-diabetic patients with myocardial infarction.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3005730 Thu, 19 Nov 2009 14:15:55 +0100 3005730 http://www.medworm.com/index.php?rid=3005729&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1202792 Exp Clin Endocrinol Diabetes 2009; 117: 593-599DOI: 10.1055/s-0029-1202792AbstractThe aim of this study was to determine whether a relatively low dose of pioglitazone or metformin was effective in diabetic patients with metabolic syndrome. Fifty diabetic patients with metabolic syndrome were randomly assigned to a low-dose pioglitazone (15 mg/day) treatment group or a low-dose metformin (500 mg/day) treatment group. Drugs were administered for 12 weeks. Systolic and diastolic blood pressure, heart rate, body mass index, triglyceride (TG), HDL and LDL-cholesterol, fasting plasma glucose (FPG), fasting plasma insulin (IRI), postprandial glucose, and HOMA-IR in the 75gOGTT, HbA1c, high-sensitivity CRP (hs-CRP) determined by cervical artery echography, and pulse wave velocity (PWV)... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3005729 Thu, 19 Nov 2009 14:15:55 +0100 3005729 http://www.medworm.com/index.php?rid=3005728&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1234087 Exp Clin Endocrinol Diabetes 2009; 117: 573-576DOI: 10.1055/s-0029-1234087Abstract Defective insulin secretion is required for the development of frank diabetes mellitus. We evaluated the secretory response of pancreatic beta cells after the ingestion of mixed meal plus oral L-arginine in newly diagnosed type 2 diabetic patients.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3005728 Thu, 19 Nov 2009 14:15:55 +0100 3005728 http://www.medworm.com/index.php?rid=3005727&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1241870 Exp Clin Endocrinol Diabetes 2009; 117: 563-566DOI: 10.1055/s-0029-1241870AbstractEpidemiological studies have suggested that obesity is associated with increased risk of several cancer types including colon, esophagus, breast (in postmenopausal women), endometrium, kidney, liver, gallbladder and pancreas. Suggested mechanisms include increased intake of potentially carcinogenic food ingredients along with excessive amount of calories, loss of cancer protective effects due to reduced physical activity, carcinogenic factors released from increased adipose tissue mass and “secondary” associations via “precursor” condition such as gallstones. The increased cancer risk in patients with obesity is a neglected topic which deserves more scientific attention. Because of its... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3005727 Thu, 19 Nov 2009 14:15:55 +0100 3005727 http://www.medworm.com/index.php?rid=3005726&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1241797 Exp Clin Endocrinol Diabetes 2009; 117: 561-562DOI: 10.1055/s-0029-1241797© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=3005726 Thu, 19 Nov 2009 14:15:55 +0100 3005726 http://www.medworm.com/index.php?rid=2941107&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1239559 Exp Clin Endocrinol Diabetes 2009; 117: 522-557DOI: 10.1055/s-0029-1239559© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  FREE: Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2941107 Fri, 30 Oct 2009 14:10:53 +0100 2941107 http://www.medworm.com/index.php?rid=2941106&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1237732 Exp Clin Endocrinol Diabetes 2009; 117: 490-495DOI: 10.1055/s-0029-1237732Abstract In the present study we evaluated anthropometric indices, serum thyroid hormones, insulin-like growth factor-1 (IGF-1) and IGF- binding proteins (IGFBPs) levels, in children who has palpable goiter at endemic population. We aimed to 1) compare children with palpable goiter with healthy peers, 2) detect interaction of anthropometric indices, serum thyroid hormones, IGF-1 and IGFBPs parameters in both groups 3) evaluate the effects of their nutritional status to these parameters.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2941106 Fri, 30 Oct 2009 14:10:53 +0100 2941106 http://www.medworm.com/index.php?rid=2941105&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1220769 Exp Clin Endocrinol Diabetes 2009; 117: 473-479DOI: 10.1055/s-0029-1220769AbstractObese patients with sepsis have higher morbidity and mortality rates than normal weight subjects. One crucial factor is the disease-associated disturbed energy balance. Ghrelin is an orexigenic peptide, mainly produced in the stomach. Leptin is an adipose-tissue derived peptide, circulating as free (fl) and receptor-bound protein (bl) acting antagonistically to ghrelin's effects on food intake. In the present study we tested the weight dependent influence of an intravenous (i.v.) ghrelin injection on leptin levels as well as hepatic protein expression in healthy and endotoxemic rats. Male Lewis rats were randomly divided into four diet-induced obese and four normal weight groups. Application of either ghrelin... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2941105 Fri, 30 Oct 2009 14:10:53 +0100 2941105 http://www.medworm.com/index.php?rid=2921748&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1234088 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1234088AbstractThe dual stable isotope method with a timed 24-h urine collection is the gold standard approach to measure fractional calcium absorption. However, the need to collect urine for 24 h makes this technique time-consuming and laborious. Our study sought to determine whether a dual isotope method using a single serum sample obtained 4 h after administration of the initial isotope provides a useful approach to measure fractional calcium absorption. Following a metabolic diet with a fixed calcium intake of 30 mmol/day for 10 days, nineteen healthy subjects age 54–74 were given a test meal with an oral isotope (Ca) followed 2 h later by an intravenous isotope (Ca). Once the oral isotope was administered, u... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2921748 Sat, 24 Oct 2009 13:06:04 +0100 2921748 http://www.medworm.com/index.php?rid=2921747&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1233448 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1233448AbstractThe prevalence of overweight and obesity is increasing worldwide. The physiological mechanisms involved in body weight regulation are complex and incompletely understood. Increasing evidence suggests that obesity is a multifactorial disease where many, if not all, organs of the body are involved. The adipose tissue was considered as a simple fat accumulation for a long period of time. However, nowadays it is fascinating to progressively discover its involvement in hormonal, inflammatory or immune system dysregulation. Adipokines and cytokines are involved in control and regulation of appetite and energy balance, glucose and lipid metabolism, neuroendocrine function, reproduction, immunity, and cardiovascular function. The infla... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2921747 Sat, 24 Oct 2009 13:06:04 +0100 2921747 http://www.medworm.com/index.php?rid=2921746&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1237706 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1237706Abstract This observational study aimed to investigate the effects of renin-angiotensin system (RAS) blockers on plasma adiponectin in subjects with metabolic syndrome (Mets) and differentiation, adiponectin expression of human omental (OM) and subcutaneous (SC) preadipocytes.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2921746 Sat, 24 Oct 2009 13:06:04 +0100 2921746 http://www.medworm.com/index.php?rid=2921745&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1225612 The objective of the study was to clarify the molecular basis of a Japanese patient of CPHD with a small anterior pituitary and an ectopic posterior pituitary.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2921745 Sat, 24 Oct 2009 13:06:04 +0100 2921745 http://www.medworm.com/index.php?rid=2921744&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1237363 This study allow the characterization of the mutational spectrum of CAH patients, mainly non-classical CAH, with 21-hydroxylase deficiency from Portugal showing specific genetic features of this population which reveals differences with worldwide countries.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2921744 Sat, 24 Oct 2009 13:06:04 +0100 2921744 http://www.medworm.com/index.php?rid=2921743&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1233452 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1233452Abstract Insulin promotes ion transportation across epithelia, mainly kidneys, leading to water and electrolyte abnormalities, possibly causing ‘insulin oedema syndrome’, which rarely presents as pleural effusion. Direct stimulation of sheep pleura by insulin and the possible electrophysiology mechanisms involved were investigated.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2921743 Sat, 24 Oct 2009 13:06:04 +0100 2921743 http://www.medworm.com/index.php?rid=2921742&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1237708 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1237708AbstractAlbright's hereditary osteodystrophy (AHO) is an inherited disorder and results from heterozygous mutation within the human Gα gene (GNAS1). AHO appears in two phenotypes, that may occur within the same family. Pseudohypoparathyroidism type Ia (PHP Ia) comprises the clinical features of AHO associated with parathyroid hormone (PTH) resistance while pseudo-pseudohypoparathyroidism (PPHP) includes AHO features without PTH resistance. In the present study we report a mother and a daughter with PPHP and PHP Ia respectively. The 13 exons of GNAS1 were analysed by PCR and direct sequencing. We identified a heterozygous missense mutation in exon 1. This novel mutation results in a stop at codon 35 and a truncated non-functional G... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2921742 Sat, 24 Oct 2009 13:06:04 +0100 2921742 http://www.medworm.com/index.php?rid=2921741&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1237701 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1237701Abstract Work-up of thyroid nodules remains challenging. Recent technologies enable determination of tissue elasticity and perfusion using ultrasound devices. The aim of the present study was to evaluate real-time elastography (RTE) and contrast-enhanced ultrasound with Sonovue (CEUS) for the differentiation of benign and malignant thyroid nodules.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2921741 Sat, 24 Oct 2009 13:06:04 +0100 2921741 http://www.medworm.com/index.php?rid=2921740&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1225350 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1225350Abstract Recombinant human thyroid-stimulating hormone (rhTSH) recently was approved as an alternative to thyroid hormone withholding (THW) to elevate TSH for thyroid remnant ablation in differentiated thyroid carcinoma patients. High ablation success rates are reported with diverse rhTSH-aided I activities. Improved renal function causes ∼50% faster radioiodine clearance under euthyroidism versus hypothyroidism. Knowledge of comparative remnant radioiodine kinetics, particularly the remnant radiation dose in Gy/GBq of administered I activity (RDpA), could assist in choosing rhTSH-aided ablative activities.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract Â... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2921740 Sat, 24 Oct 2009 13:06:04 +0100 2921740 http://www.medworm.com/index.php?rid=2921739&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1234086 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1234086Abstract Withdrawal of levothyroxine with resultant hypothyroidism is still used in preparation for I-131 diagnostic whole-body scan (DWBS) and thyroglobulin (TG)-measurement in patients afflicted with differentiated thyroid cancer (DTC). Recombinant human thyroid-stimulating hormone (rhTSH) enhances TSH stimulation obviating the clinical and economical consequences of hypothyroidism. Primary aim of this study was an intraindividual comparison of diagnostic follow-up measurements under these two sets of conditions by taking clinical and socio-economic parameters into account. Second aim was to determine a clear patient preference for the one method or the other.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkG... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2921739 Sat, 24 Oct 2009 13:06:04 +0100 2921739 http://www.medworm.com/index.php?rid=2921738&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1237704 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1237704Abstract Adrenal incidentalomas (AIs) constitute an emerging clinical entity due to the increased use of abdominal imaging for diagnostic purposes. Most often it consists of benign-nonfunctioning lesions and an increase in size during follow-up is reported in about 9% (0–26%), whereas their functional evolution is rare.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2921738 Sat, 24 Oct 2009 13:06:04 +0100 2921738 http://www.medworm.com/index.php?rid=2921737&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1225649 The objective of the present study was to determine the effects of chronic treatment with acetone in oxidative stress and metabolic parameters in rats. Twenty male Wistar rats were divided into two groups: control (CG) and chronic acetone group (CAG). After 28 days of acetone ingestion in a 5% aqueous solution (CAG) or water (CG) the animals were euthanized and urine, plasma and liver were collected for the determination of acetone, glucose, lipemia, hepatic fat, malondialdehyde (MDA), reduced glutathione (GSH), and vitamin E. As expected, urinary and plasma acetone levels were higher in CAG. There was no difference in hepatic MDA values between groups, whereas hepatic GSH was lower in CAG than in CG and hepatic vitamin E was higher in CAG than in CG. There was also an increase in glycemia... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2921737 Sat, 24 Oct 2009 00:37:51 +0100 2921737 http://www.medworm.com/index.php?rid=2902393&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1238318 In conclusion, isolated human islets may be used for in vitro experiments for up to three weeks. During this time islet function and islet-cell turnover are stable. If islet culture is extended beyond three weeks ER stress may impair islet viability. Studies analyzing the pathophysiology of human T2D at the level of the endocrine pancreas need to confirm results obtained with isolated human islets by analysis of primary human pancreatic tissue.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2902393 Sun, 18 Oct 2009 00:31:38 +0100 2902393 http://www.medworm.com/index.php?rid=2896382&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1224121 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1224121AbstractThe aim of this study was to evaluate Achilles tendon (AT) in type 2 diabetic patients with vs. without peripheral neuropathy using Magnetic Resonance Imaging (MRI). The study included 19 patients (group A, mean age 63.9±7.4 years) with peripheral neuropathy and 19 patients (group B, mean age 63.6±6.1 years) without peripheral neuropathy, as well as 16 healthy controls (group C, mean age 61.6±8.4 years). Neuropathy was diagnosed by the Diabetic Neuropathy Index (DNI). The maximum AT thickness and AT volume were measured on sagittal T weighted MRI images. AT volume was calculated by the sum of the tendon surface area of all contiguous sections multiplied by the slice thickness. Diabetic patients had significantly (p<0.001)... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2896382 Fri, 16 Oct 2009 13:08:26 +0100 2896382 http://www.medworm.com/index.php?rid=2896381&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1238319 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1238319Abstract Non-enzymatic glycation is a process, which leads to the formation of advanced glycation endproducts. These compounds are involved in the development of diabetic microvascular complications. Fructosamine-3-kinase (FN3K) is an intracellular enzyme that phosphorylates fructosamines resulting in fructosamine-3-phosphate, which subsequently decomposes to inorganic phosphate, 3-deoxyglucasone and the unmodified amine. Recently, the G900C (rs1056534) single nucleotide polymorpism (SNP) of the FN3K gene was found to be associated with the enzyme activity.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocr... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2896381 Fri, 16 Oct 2009 13:08:26 +0100 2896381 http://www.medworm.com/index.php?rid=2896380&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1234065 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1234065AbstractPioglitazone is used to improve insulin sensitivity in type 2 diabetes. This group of drugs is usually well tolerated; however, their use may be associated with several adverse effects including edema, weight gain, macular edema and heart failure. Herein we report a patient who developed pancytopenia on the 7th day of oral pioglitazone treatment for the control of diabetes mellitus and fully recovered 6 days after the cessation of this drug. To the best of our knowledge this is the first reported case of pancytopenia induced by pioglitazone therapy.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocr... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2896380 Fri, 16 Oct 2009 13:08:26 +0100 2896380 http://www.medworm.com/index.php?rid=2896379&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1237361 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1237361AbstractImpaired glucose tolerance and diabetes have been associated with depression, and antidepressant treatment is assumed to improve impaired glucose tolerance. However, antidepressant treatment is also considered as a risk factor for the development of diabetes. Reports about glucose tolerance under antidepressant treatment frequently lack appropriate control groups. We conducted the oral glucose tolerance test (OGTT) in 10 healthy controls selected from an epidemiological sample with a negative lifetime history of mental Axis I disorder. Controls were carefully matched to a sample of inpatients with major depression that participated in an OGTT before and after antidepressant treatment with mirtazapine. All participants underwent... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2896379 Fri, 16 Oct 2009 13:08:26 +0100 2896379 http://www.medworm.com/index.php?rid=2896378&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1225647 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1225647AbstractThe relationship between type 2 diabetes, antioxidant-enzyme serum ceruloplasmin, pro-inflammatory blood fibrinogen and antioxidant activity (AOA) was investigated in 40 diabetics and 47 non-diabetics hailing from South India as a preliminary study aspiring to be a crucial stepping stone for a large study. Serum AOA was lower (p<0.01) in diabetics (0.68±0.03 mmol/L) than controls (0.92±0.07 mmol/L) and ceruloplasmin more (p<0.001) in diabetics (983.20±52.18 mg/L) than controls (470.79±39.20 mg/L). Plasma fibrinogen was higher (p<0.001) in diabetics (480.23±19.52 mg/dl) than controls (313.94±13.42 mg/dl). Males had more AOA. Fibrinogen increased with age. These significant findi... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2896378 Fri, 16 Oct 2009 13:08:26 +0100 2896378 http://www.medworm.com/index.php?rid=2896377&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1239518 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1239518Abstract Insulin-like growth factor binding protein-1 (IGFBP-1) is known to regulate the bioavailability of insulin-like growth factor (IGF) and the levels of IGFBP-1 are increased in the morning in patients with type 1 diabetes mellitus. We investigated the nocturnal fluctuations of glucose, IGFBP-1, and free IGF-1 levels with three insulin regimens.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2896377 Fri, 16 Oct 2009 13:08:26 +0100 2896377 http://www.medworm.com/index.php?rid=2896376&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1237381 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1237381Abstract We investigated the effect of thoracic epidural anesthesia on perioperative blood glucose levels in diabetic patients undergoing cardiopulmonary bypass by continuous insulin infusion according to the Portland Protocol.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2896376 Fri, 16 Oct 2009 13:08:26 +0100 2896376 http://www.medworm.com/index.php?rid=2896375&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1233453 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1233453AbstractModerate alcohol consumption is associated with increased insulin sensitivity and reduced cardiovascular risk. We hypothesized that this relates to a direct effect of alcohol and therefore investigated whether acute alcohol intake altered insulin sensitivity or endothelial function in patients with type 2 diabetes. In an open-label two period design, the effect of a single oral dose of 40 g of alcohol (168 ml 40% vodka) on an insulin-modified frequently sampled intravenous glucose tolerance test (FSIGT) and on endothelium-dependent (flow mediated, FMD) or endothelium-independent (glyceroltrinitrate (GTN)-induced) vasodilation of the brachial artery measured by ultrasound was studied. Experiments were carried out in ... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2896375 Fri, 16 Oct 2009 13:08:26 +0100 2896375 http://www.medworm.com/index.php?rid=2896374&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1225648 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1225648Abstract Atherothrombosis can present as coronary artery disease (CAD) cerebrovascular disease (CVD) and peripheral arterial disease (PAD). It is unknown whether diabetics with CAD differ from those with other manifestations of atherothrombosis such as CVD or PAD regarding clinical characteristics, biochemical parameters, or medications.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2896374 Fri, 16 Oct 2009 13:08:26 +0100 2896374 http://www.medworm.com/index.php?rid=2896373&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1237360 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1237360Abstract Visfatin (nampt) and ghrelin are the most recently identified adipocytokines, but their role in atherosclerosis is poorly clarified. In our study we investigated their association with advanced carotid atherosclerosis and carotid intima-media thickness (CIMT) in patients with type 2 diabetes mellitus (T2DM).[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2896373 Fri, 16 Oct 2009 13:08:26 +0100 2896373 http://www.medworm.com/index.php?rid=2896372&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1224151 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1224151Abstract CD40 signalling has been associated with the pathogenesis of autoimmune diseases and diseases with low-grade chronic inflammation.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2896372 Fri, 16 Oct 2009 13:08:26 +0100 2896372 http://www.medworm.com/index.php?rid=2896371&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1225610 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1225610AbstractActivation of the Smad signalling pathway has been implicated in the pathological process of diabetic associated complications. The current study was designed to see whether Smad signalling was activated in the hippocampus of streptozotocin-induced diabetic rats. Compared with vehicle-treated controls, immunoblot analysis of hippocampal extracts showed that phosphorylated Smad2 was upregulated at 8 weeks post streptozotocin induction (p<0.01), and phosphorylated Smad3 protein was upregulated at 4 and 8 weeks post streptozotocin induction (p<0.01) in streptozotocin-induced diabetic rats. In addition, immunofluorescence labelling assay showed that the percentage of pSmad2 immunoreactive astrocytes increased significantly in... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2896371 Fri, 16 Oct 2009 00:54:26 +0100 2896371 http://www.medworm.com/index.php?rid=2856649&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1225615 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1225615AbstractTwelve human cancer cell lines and one non-malignant cell line were investigated with respect to a potential antiproliferative/cytotoxic activity of molecular iodine and iodolactones. Except CCL221 colon carcinoma cells, the growth of all cancer cell lines decreased if the cells were cultured in the presence of 10 μM molecular iodine (I) for at least two days. δ-iodolactone (IL, 5 μM) was found to have a similar effect. SH-SY5Y neuroblastoma cells turned out to be most susceptible to both iodine compounds (total inhibition), followed by MCF-7 mammary carcinoma cells (60% and 77.7% inhibition in the presence of I respect. IL) and HS24 lung carcinoma cells (36.3% respect. 40.3% inhibition). In contrast,... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2856649 Sat, 03 Oct 2009 00:45:16 +0100 2856649 http://www.medworm.com/index.php?rid=2848356&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1231082 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1231082Abstract Spermatogenesis and epididymal function depend on testicular steroids with estrogens being important regulatory factors. However, testicular estrogen secretion shows distinct species specificities, with the boar being characterized by the production of high amounts of estrone [E1] and estronesulphate [E1S]. As the boar testis also expresses estrogen sulphatase [StS] and sulphotransferase [EST] the present paper is based on the hypothesis that local availability of biologically active estrogens results from an interplay between estrogen synthesis and local activities of StS and EST.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2848356 Thu, 01 Oct 2009 00:41:59 +0100 2848356 http://www.medworm.com/index.php?rid=2710432&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1231083 We report two patients who presented with excessively elevated calcitonin levels. Diagnostic work-up revealed a single thyroid nodule and a pancreatic tumor with ectopic calcitonin secretion in both of them. On the basis of these case reports, the diagnostic work flow and management in case of clearly elevated calcitonin levels are described and discussed.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2710432 Wed, 19 Aug 2009 10:22:19 +0100 2710432 http://www.medworm.com/index.php?rid=2710431&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1225646 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1225646AbstractAutoimmune hypophysitis (AH) is an inflammatory disease that can present either as empty sella or as pituitary mass. A 16-years-old girl was admitted at our Unit for primary amenorrhea. A pituitary MRI performed 2 years before for severe headache demonstrated a large sellar and suprasellar lesion. As a craniopharyngioma was suspected, the consultant neurosurgeon suggested the removal of the lesion. Two months later, a preoperative MRI showed the disappearance of the lesion and a residual empty sella, figure consistent with AH. When the patient came at our observation, basal and dynamic testing documented a state of hypopituitarism, high titers of antipituitary antibodies and a partial empty sella at MRI. Hormonal replacement th... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2710431 Wed, 19 Aug 2009 10:22:19 +0100 2710431 http://www.medworm.com/index.php?rid=2710430&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1225611 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1225611Abstract We determined the prevalence of anterior pituitary dysfunction in a multi-centre screening program across five German endocrine centres in patients rehabilitating from TBI (GCS<13).[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2710430 Wed, 19 Aug 2009 00:39:49 +0100 2710430 http://www.medworm.com/index.php?rid=2672739&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1215589 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1215589Abstract Albright hereditary osteodystrophy (AHO) and Pseudohypoparathyroidism type Ia (PHPIa) are caused by an inherited deficiency of Gsα, encoded by the gene. Apart from an exclusive first exon, Gsα shares part of the transcribed regions with NESP55, Exon A/B and XLαs, whose gene products utilize alternative promoter regions of this complex gene locus. However, it is not known, whether the deficiency of all gene products contributes to the AHO and PHPIa phenotype or if they are even causative for some specific symptoms. In these cases, mutations affecting selectively exon 1, coding only for Gsα, would lead to a different phenotype than mutations affecting the common exons 2–13.[...]© J. A. Barth Verlag in ... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2672739 Thu, 06 Aug 2009 10:56:34 +0100 2672739 http://www.medworm.com/index.php?rid=2672738&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1224156 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1224156Abstract We aimed to compare the changes of endothelial function and haemostatic, inflammatory and metabolic parameters of short-term iatrogenic hypothyroidism to the characteristics of subclinical hyperthyroidism in patients with differentiated thyroid cancer.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2672738 Thu, 06 Aug 2009 00:44:01 +0100 2672738 http://www.medworm.com/index.php?rid=2632006&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1225337 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1225337Abstract There is insufficient information about the use of continuous subcutaneous insulin infusion (CSII) versus multiple daily injections (MDI) using long-acting insulin analogs in relation to possible metabolic consequences and, as well, on the grade of patient satisfaction. The aim of the study was to evaluate the usefulness of CSII treatment in patients with type 1 diabetes in achieving glycemic objectives using continuous glucose monitoring system (CGMS) and in improving patient's satisfaction with treatment.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2632006 Fri, 24 Jul 2009 10:55:07 +0100 2632006 http://www.medworm.com/index.php?rid=2632005&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1225338 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1225338Abstract Aim of the present study is to compare control of hyperglycaemia and other diabetes-related cardiovascular risk factors during the years 1998 and 2006 and to estimate the change in the cost of medications prescribed for this purpose.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2632005 Fri, 24 Jul 2009 10:55:07 +0100 2632005 http://www.medworm.com/index.php?rid=2632004&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1220936 In conclusion, total and acylated ghrelin levels after a mixed meal test were similar in type 2 diabetic patients treated with metformin, pioglitazone or diet therapy alone. These results suggest that changes in body weight during metformin and pioglitazone treatment are not associated with plasma ghrelin levels.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2632004 Fri, 24 Jul 2009 10:55:07 +0100 2632004 http://www.medworm.com/index.php?rid=2632003&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1225333 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1225333Abstract One major objective is to reduce the risk of lower limb amputation in diabetes mellitus. Nationwide data to incidences of amputations in the diabetic and non-diabetic populations in Germany as well as relative and attributable risks due to diabetes are lacking so far.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2632003 Fri, 24 Jul 2009 10:55:07 +0100 2632003 http://www.medworm.com/index.php?rid=2632002&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1225352 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1225352AbstractCurrent Japanese and American diets and Japanese diet immediately after the War were converted to laboratory animal diets. As a result, current laboratory animal diet (CA-1, CLEA) unexpectedly resembled the diet of Japanese after the War. This is considered to result in an under-evaluation of diabetes research using laboratory animals at present. Therefore, changes in insulin signals caused by current Japanese and American diets were examined using deficient mice ( mice) and mechanisms of aggravation of type 2 diabetes due to modern diets were examined. mice at 6 weeks of age were divided into three groups: Japanese diet (Jd) group, American diet (Ad) group and CA-1 diet [regular diet (Rd)] group. Each diet was given to the dam... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2632002 Fri, 24 Jul 2009 10:55:07 +0100 2632002 http://www.medworm.com/index.php?rid=2632001&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1225354 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1225354AbstractComputing Na and water deficits of hyperosmolar coma (HC) is important in correcting the derangement, to avoid unwanted iatrogenic electrolyte derangements and brain oedema. This paper derives and applies formulas valid when GA (glucose accumulation) >2·ΔNa (sodium loss), with or without ΔV (water depletion). We built a model system and wrote the equations describing the relationships between volume and concentration of solutes within the body water compartments. HC was simulated on computer experiments by adding GA in different amounts combined with a large variety of ΔNa and ΔV. The ensuing concentrations in Na (PNaNone.) and glucose (PG) were used to identify the condition GA >2 · ΔNa, Δ... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2632001 Fri, 24 Jul 2009 01:14:54 +0100 2632001 http://www.medworm.com/index.php?rid=2607587&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1225339 The objectives of this study are to assess the perceptions of endocrinologists regarding sufficient preoperative preparation for resection of pheochromocytoma (PHEO) and to evaluate how patients with PHEO are actually managed preoperatively. A survey on methods of preoperative preparation was sent to all 39 endocrinologists who had privilege at a large academic hospital. The charts of 43 patients who underwent adrenalectomy for PHEO resection at this hospital between 1997 and 2007 were reviewed. Age, tumor size, blood pressure medications, volume assessment and repletion, duration of preparation, preoperative and intraoperative blood pressures, and length of stay were recorded. Sixteen endocrinologists (41%) returned surveys, with 15 questionnaires completely answered. Seven endocrinologis... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2607587 Fri, 17 Jul 2009 10:53:48 +0100 2607587 http://www.medworm.com/index.php?rid=2607586&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1220771 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1220771AbstractThe severity of Cushing's Syndrome (CS) depends on the duration and extent of the exposure to excess glucocorticoids. Current measurements of cortisol in serum, saliva and urine reflect systemic cortisol levels at the time of sample collection, but cannot assess past cortisol levels. Hair cortisol levels may be increased in patients with CS, and, as hair grows about 1 cm/month, measurement of hair cortisol may provide historical information on the development of hypercortisolism. We attempted to measure cortisol in hair in relation to clinical course in six female patients with CS and in 32 healthy volunteers in 1 cm hair sections. Hair cortisol content was measured using a commercially available salivary cortisol i... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2607586 Fri, 17 Jul 2009 10:53:48 +0100 2607586 http://www.medworm.com/index.php?rid=2607585&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1202795 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1202795Abstract For thyroid tumors increased as well as decreased vessel densities have been reported. Because of different morphometric methods and specificities of previously used antibodies for small and large vessels our objective was to investigate and compare the density of large vessels and microvessels by different morphometric methods and antibodies in hot nodules(HN), cold nodules (CN), papillary carcinoma (PC) and Graves’ disease (GD) to try to clarify some of these discrepancies.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2607585 Fri, 17 Jul 2009 10:53:48 +0100 2607585 http://www.medworm.com/index.php?rid=2607584&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-2008-1080924 This study aimed to investigate changes in GH/IGF-I axis in adults undergoing open heart surgery.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2607584 Fri, 17 Jul 2009 10:53:48 +0100 2607584 http://www.medworm.com/index.php?rid=2607583&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0028-1112154 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0028-1112154Abstract The contribution of genetic factors to the development of menopausal obesity has been widely recognized. Peroxisome proliferator-activated receptor gamma (PPARγ) is involved in adipocyte differentiation and has been suggested to influence insulin sensitivity. The aim of this study was to evaluate the frequency of Pro12Ala PPARγ polymorphism and its association with body mass index (BMI) and metabolic syndrome parameters in postmenopausal Polish women.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2607583 Fri, 17 Jul 2009 10:53:48 +0100 2607583 http://www.medworm.com/index.php?rid=2607582&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1224152 In conclusion, the present study demonstrated that lower serum LDL-Chol levels were related to vertebral fracture risk independent of renal function, age, body size, bone metabolism parameters and the severity of the disease in pHPT women.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2607582 Fri, 17 Jul 2009 10:53:48 +0100 2607582 http://www.medworm.com/index.php?rid=2607581&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1225616 The objective of the present study was to analyse the associations between anthropometric measurements and hormone levels including serum thyroid stimulating hormone (TSH), prolactin, insulin-like growth factor (IGF) I, and testosterone. Form the cross-sectional Study of Health in Pomerania 1  women and 1 864 men aged 20–79 years were included in the analyses. Serum TSH, prolactin, IGF-I, and testosterone levels were determined by immunochemiluminescent procedures. Body height, weight as well as waist and hip circumferences were measured. Body mass index (BMI), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR) were calculated. Our analyses revealed inverse linear associations of waist and hip circumferences, BMI and WHtR with serum TSH levels and linear associati... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2607581 Fri, 17 Jul 2009 10:53:48 +0100 2607581 http://www.medworm.com/index.php?rid=2607580&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1224154 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1224154Abstract A 23-year-old male was referred to our clinic with diagnosis of idiopathic isolated growth hormone deficiency. A detailed family history revealed short stature and swelling of legs which only affected females in four generations of his family.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2607580 Fri, 17 Jul 2009 10:53:48 +0100 2607580 http://www.medworm.com/index.php?rid=2607579&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1220688 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1220688Abstract The impact of growth hormone (GH) replacement on plasma brain natriuretic peptide (BNP) in association with cardiac morphology and function in adults with growth hormone deficiency (GHD) was evaluated.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2607579 Fri, 17 Jul 2009 10:53:48 +0100 2607579 http://www.medworm.com/index.php?rid=2607578&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1225353 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1225353Abstract To investigate the changes of insulin resistance and fasting plasma ghrelin levels in adolescents with obesity and family history of type 2 diabetes mellitus (FHD) and analyze its related factors.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2607578 Fri, 17 Jul 2009 00:41:13 +0100 2607578 http://www.medworm.com/index.php?rid=2585864&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-2007-1004553 Exp Clin Endocrinol Diabetes 2009; 117: 361-364DOI: 10.1055/s-2007-1004553Abstract Cerebrospinal fluid (CSF) rhinorrhea and consecutive meningitis are well recognised clinical features of macroprolactinomas invading the skull base and are mainly observed under a dopamine-agonist therapy regimen. To our knowledge, a clinical case of primary meningitis due to an untreated macroprolactinoma, without any history of rhinorrhea, has not been reported previously in the English literature.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2585864 Fri, 10 Jul 2009 10:55:28 +0100 2585864 http://www.medworm.com/index.php?rid=2489422&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1216351 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1216351Abstract To determine whether there is an independent association between the Pro12Ala polymorphism in the peroxisome proliferator-activated-receptor γ2 (PPARγ2)-gene and the extent of coronary artery disease in men.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2489422 Thu, 25 Jun 2009 07:37:34 +0100 2489422 http://www.medworm.com/index.php?rid=2489421&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1220689 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1220689Abstract Diabetes mellitus (DM) is a serious health and social problem. We assessed the prevalence of DM and metabolic syndrome in an urban population in southern Poland.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2489421 Thu, 25 Jun 2009 07:37:34 +0100 2489421 http://www.medworm.com/index.php?rid=2489420&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1214426 This article describes the results of an audit comparing the maternal and foetal outcomes for 2 cohorts of patients with GDM treated in the UHCW Trust in 2000–2 and 2006–8. Between 2000–2 and 2006–8 there was a significant reduction in mean maternal glycosylated haemoglobin (HbA1c) in trimester 3 of pregnancy, mean foetal birth weight and neonatal admission rate to the special care baby unit (SCBU). This evidence suggests that introduction of the measures recommended by NICE can effect significant improvement in maternal glycaemic control and foetal outcomes.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2489420 Thu, 25 Jun 2009 07:37:34 +0100 2489420 http://www.medworm.com/index.php?rid=2489419&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1216352 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1216352Abstract The peroxisome proliferator-activated receptor-γ () Pro12Ala and the co-activator-1α () Gly482Ser polymorphisms (SNPs) have been associated with type 2 diabetes mellitus (T2DM) risk. We hypothesized that independent and interactive effects of the Pro12Ala and Gly482Ser polymorphisms influence T2DM intermediate phenotypes.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2489419 Thu, 25 Jun 2009 07:37:34 +0100 2489419 http://www.medworm.com/index.php?rid=2489418&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1220739 The objective of this study was to determine the clinical characteristics and risk factors associated with RLS among persons with diabetes.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2489418 Thu, 25 Jun 2009 07:37:34 +0100 2489418 http://www.medworm.com/index.php?rid=2489417&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1220763 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1220763Abstract Hypertension is one of the major complications of pregnancy. Its impact in type 2 diabetic pregnant women could be understimated because it is generally evaluated by retrospective studies and as one of the outcome measures.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2489417 Thu, 18 Jun 2009 00:44:39 +0100 2489417 http://www.medworm.com/index.php?rid=2470486&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1202794 Exp Clin Endocrinol Diabetes 2009; 117: 274-282DOI: 10.1055/s-0029-1202794Abstract Chronic exposure to high levels of free fatty acid (FFA) has adverse effects on the function of pancreatic beta-cell, with a consequent increase in the production of reactive oxygen species. Poly (ADP-Ribose) polymerase (PARP-1) overactivation leads to massive NAD consumption and ATP depletion with induction of cellular necrosis under high reactive oxygen species. In the present study, we investigated whether inhibitors of poly(ADP-ribose) polymerase were capable of protecting beta-cells from death induced by extended exposure to FFA.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical E... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2470486 Thu, 11 Jun 2009 04:54:30 +0100 2470486 http://www.medworm.com/index.php?rid=2434337&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1216376 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1216376AbstractThe renin-angiotensin system (RAS) is altered in diabetes. The aim of our study was to investigate whether streptozotocin-induced diabetes was associated with a change in angiotensin II receptors AT and angiotensin-converting enzyme (ACE) mRNA expression in the pancreas in vivo. Rats were synchronized to a 12:12 light:dark cycle. Pancreas tissue sampling was done at 4 h intervals during 24 h cycle starting 17 days after streptozotocin (STZ) treatment (65 mg/kg of body weight). Real time PCR showed decreased expression of ACE in the pancreas after STZ administration during the dark phase. Expression of AT was decreased in diabetic rats during the light and the dark phase of 24 h cycle. Our data show down-... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2434337 Wed, 27 May 2009 00:50:35 +0100 2434337 http://www.medworm.com/index.php?rid=2434336&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1202273 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1202273AbstractObesity in human was found mainly due to the poor transportation of leptin through brain-blood barrier (BBB), called as leptin resistance. To produce a leptin capable of penetrating BBB, we have added Tat-PTD(9) to the C terminal of leptin to construct a fusion protein. The fusion Tat-leptin and native leptin genes were synthesized by single-step insertion of a polymerase chain reaction and expressed in BL21 (Rosseta). The expressing products were purified and renatured by Ni-NTA affinity chromatography, and identified by the molecular size in SDS-PAGE gel and by its immunoreactivity to specific antibody with Western-blotting assay. To bio-functionally evaluate the fusion protein, Balb/c mice fed with high-fat diet (HFD) were g... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2434336 Wed, 27 May 2009 00:50:35 +0100 2434336 http://www.medworm.com/index.php?rid=2434335&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1214385 In this study we concentrated on relationship between as a very important gastroduodenal pathogen and autoimmune thyroiditis (AT). Forty seven AT patients and 34 healthy controls were enrolled. They were split into: THP ( positive patients, n=17), THN ( negative patients, n=30), CP ( positive controls, n=17) and CN groups ( negative controls, n=17). By protein microarray we analysed production of 23 cytokines and chemokines prior and post stimulation with lysate and its lipopolysacharide (LPS). Reactivity to lysate as well as to bacterial LPS differed within groups. The lowest basal cytokine and chemokine production was observed in CN group but these subjects reacted significantly to specific stimulation by increasing IFN-gamma (in comparison with THP p=0.01 for LPS and p=0.004 for lysate)... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2434335 Wed, 27 May 2009 00:50:35 +0100 2434335 http://www.medworm.com/index.php?rid=2434334&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1202774 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1202774AbstractThis is a study of a cohort of 117 men aged between 34–69 years, with plasma testosterone levels between 5.9–12.1 nmol/L (N>14.0 nmol/L) who were treated with administration of testosterone undecanoate for 1 year as the sole intervention. There was a remarkable improvement of body weight, BMI and waist size along with an improvement of lipid profiles. Liver fat is highly significantly and linearly correlated with all components of the metabolic syndrome. Hepatic inflammation secondary to liver steatosis is a potential contributor to the low-grade inflammation associated with the metabolic syndrome. Elevations of liver enzymes are associated with higher CRP concentrations. Levels of ALT (GPT) AST (GOT)... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2434334 Wed, 27 May 2009 00:50:35 +0100 2434334 http://www.medworm.com/index.php?rid=2434333&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1215588 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1215588AbstractThe reasons for the increase of pituitary tumor-transforming gene (PTTG) transcripts in about 90% of pituitary adenomas are still not fully understood, although upregulation by basic fibroblast growth factor (bFGF) has been discussed as a potential cause. A possible influence of the Insulin like Growth Factor 1 (IGF-1) might be of interest, since this protein is also synthesized in most pituitary adenomas. Moreover, the principal regulation of the PTTG gene by IGF-1 and Insulin has been demonstrated in astrocytoma and breast cancer cells. We analyzed a large group (103 patients) of unselected clinical pituitary adenoma samples. From total RNA of frozen tumor samples (all subtypes) cDNA () was synthesized and transcripts of PTTG... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2434333 Wed, 27 May 2009 00:48:56 +0100 2434333 http://www.medworm.com/index.php?rid=2407666&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0028-1103299 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0028-1103299AbstractObesity-resistance in knockout mice indicate an important role of α2-Heremans-Schmid glycoprotein/fetuin-A (AHSG) in the development of obesity. We studied whether genetic variation within affects whole-body adiposity and regional fat distribution in humans. We genotyped 321 subjects at increased risk for type 2 diabetes for five single nucleotide polymorphisms (SNP) rs2248690, rs4831, rs2070635, rs4917, and rs1071592. Body fat distribution and ectopic hepatic and intramyocellular lipids were assessed by magnetic resonance techniques. AHSG levels were determined by immunoturbidimetry. The five chosen SNPs covered 100% of common genetic variation (minor allele frequency ≥0.05) within (r≥0.8). All SNPs were signi... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2407666 Fri, 15 May 2009 08:15:18 +0100 2407666 http://www.medworm.com/index.php?rid=2407665&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1192044 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1192044AbstractThe incidence of obesity has increased dramatically during recent decades. Obesity will cause a decline in life expectancy for the first time in recent history due to numerous co-morbid disorders. Adipocyte and adipose tissue dysfunction belong to the primary defects in obesity and may link obesity to several health problems including increased risk of insulin resistance, type 2 diabetes, fatty liver disease, hypertension, dyslipidemia, atherosclerosis, dementia, airway disease and some cancers. However, not all obese individuals develop obesity related metabolic or cardiovascular disorders potentially due to a preserved normal adipose tissue architecture and function. The majority of patients with obesity have an impaired adip... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2407665 Fri, 15 May 2009 08:15:18 +0100 2407665 http://www.medworm.com/index.php?rid=2407664&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1202275 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1202275Abstract The validity of low-dose 1 μg cosyntropin test (LDT) is reported mainly for the assessment of secondary adrenocortical insufficiency (AI). Likewise the hypothalamic-pituitary disorders, early diagnosis of the initial or partial stages of primary AI has an important role.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2407664 Fri, 15 May 2009 08:15:18 +0100 2407664 http://www.medworm.com/index.php?rid=2407663&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1214427 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1214427Abstract Mutations in the glucokinase gene (GCK) produce a subtype of Maturity onset diabetes in the young (MODY), named MODY 2. To date over than 190 different mutations have been identified, distributed over the coding regions and the exon–intron boundaries of the gene. The aim of this work was to study the nature and frequency of mutations in the GCK gene, in a MODY clinically characterized Argentinean population.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2407663 Fri, 15 May 2009 08:15:18 +0100 2407663 http://www.medworm.com/index.php?rid=2407662&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1202830 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1202830AbstractThe immune response can be triggered by molecules derived from microorganisms (PAMP) or from molecules derived from damaged or dead host cells, known as the damage-associated molecular-pattern molecules (DAMP). Their immune effects are accompanied by altered redox environment. The level of stable end products of nitric oxide (NO)- plasma nitrate and nitrite (NOx), carbonyl groups (PCO) and nitrotyrosine (NTY), in relation to the metabolism of dsRNAs (poly I:C and poly A:U) and xanthine oxidase (XO activity), in plasma of type2 diabetic patients was determined. Thirty-six patients with type 2 diabetes (age group 34–66 years, 19 male and 17 female) were allocated to the study. Diabetic patients had a significantly higher le... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2407662 Fri, 15 May 2009 08:15:18 +0100 2407662 http://www.medworm.com/index.php?rid=2407661&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0028-1103286 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0028-1103286Abstract To picture the profile of type 2 diabetic patients in Belgium and to study the quality of care in the primary care setting, with regard, to multi-factorial approach of the disease.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2407661 Fri, 15 May 2009 08:15:18 +0100 2407661 http://www.medworm.com/index.php?rid=2407660&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0028-1119406 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0028-1119406AbstractWe observed the effects of the combination of a high-fat diet and chronic stress on insulin resistance. Male Wistar rats were fed on either a control or a high-fat diet and given chronic stress with the electric foot shock or not for 10 weeks. After checking the glucose infusion rate (GIR) and the HOMA-IR index, the results showed that the three groups all revealed insulin resistance with increased free fatty acid (FFA), adrenocorticotropic hormone (ACTH) and corticosterone in the serum, in addition to increased tumour necrosis factor α (TNF-α) in the serum and adipose tissue, and decreased density of high affinity receptors (R1) and expression of peroxisome proliferator-activated receptor-α (PPARα) mRNA in ... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2407660 Fri, 15 May 2009 08:15:18 +0100 2407660 http://www.medworm.com/index.php?rid=2407659&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1202274 We report two cases of large mixed adrenal tumors, with heterogeneous appearance and areas of fat density in imaging techniques, and with autonomous cortisol production leading to Cushing's syndrome. Both underwent adrenalectomy and the histological study showed an adrenocortical adenoma with widespread myelolipomatous metaplasia. Hypercortisolism resolved in the one patient that could be evaluated after surgery. We review all the previous reported cases of hypercortisolism associated with adrenal myelolipomas. We also discuss the recommended diagnostic approach and therapeutic management of adrenal masses of lipomatous appearance.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimenta... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2407659 Fri, 15 May 2009 08:15:18 +0100 2407659 http://www.medworm.com/index.php?rid=2407658&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1202831 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1202831AbstractPituitary adenomas account for about 10% of all intracranial neoplasms and for about 85% of all pituitary tumors. In addition, prospective studies of normal persons and postmortem examinations reveal pituitary adenomas in up to 10% of adults indicating that not all pituitary adenomas are clinically significant. With clinically significant pituitary adenomas, patients may present with hyper- or under-secretion of pituitary hormones or with symptoms and signs of space occupying intracranial tumor like headache and visual compromise. Like other differentiated neuroendocrine cells, the anterior pituitary displays remarkable plasticity in response to physiological demands, as exemplified by the lactotroph differentiation and prolife... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2407658 Fri, 15 May 2009 08:15:18 +0100 2407658 http://www.medworm.com/index.php?rid=2407657&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1202272 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1202272AbstractInsulinomas are rare, mostly benign neuroendocrine tumours with an incidence of approximately four cases per million person per year. Only isolated case reports of insulinomas occurring in pregnancy have been documented. Clinical signs and symptoms of insulinoma appear to be attenuated and, in some cases, even masked by pregnancy. Therefore, in the present overview of insulinomas occurring during pregnancy, special attention is paid to potential factors contributing to the altered insulin response during pregnancy.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2407657 Fri, 15 May 2009 08:15:18 +0100 2407657 http://www.medworm.com/index.php?rid=2407656&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1202276 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1202276AbstractA 72 year old man presented with progressive dysphagia. A poorly differentiated thyroid carcinoma occluding the esophagus was diagnosed. The trachea was initially unaffected. This mode of presentation for a thyroid carcinoma is very uncommon.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2407656 Fri, 15 May 2009 08:15:18 +0100 2407656 http://www.medworm.com/index.php?rid=2407655&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1202851 We report on a 64-year-old patient in whom fentanyl therapy was found to be responsible for the induction of secondary adrenal insufficiency as clearly demonstrated by re-exposure. We conclude that given the widespread use of opiates in chronic pain management physicians should raise their level of awareness for adrenal insufficiency and look for it generously. Opiates should be added to the list of differential diagnoses to be considered routinely in patients with newly diagnosed secondary adrenal insufficiency.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes) Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2407655 Fri, 15 May 2009 08:15:16 +0100 2407655 http://www.medworm.com/index.php?rid=2407654&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1202832 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1202832AbstractHomo- and heterodimers of platelet-derived growth factor-A (PDGF-A) and PDGF-B chains are involved through PDGF α- and β-receptors in the growth regulation of multiple normal and tumoural cell types as well as in tumour neovascularization. Since little information is available on the impact of PDGF/PDGF receptors in normal and adenomatous pituitary, we studied the expression and action of this growth factor system in a variety of pituitary tumour cell lines and in rat anterior pituitary cell cultures. By RT-PCR, mRNA expression of PDGF-A and -B chains and of both receptors was found in rat pituitary and mouse folliculostellate TtT/GF pituitary tumour cells. Rat somatotroph MtT-S and mouse corticotroph AtT20 tumor cell... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2407654 Fri, 15 May 2009 08:15:16 +0100 2407654 http://www.medworm.com/index.php?rid=2407653&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1214386 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1214386AbstractIt is well established, that the increased mortality in patients with acromegaly is due to cardiac diseases. Cardiomyopathy is the predominant cardiac alteration in patients with acromegaly. There are less data about coronary heart disease or coronary calcifications. Electron beam computed tomography (EBCT) is the standard imaging modality for identification of coronary artery calcifications (CAC) and can determine the extent and severity of coronary atherosclerosis. Coronary risk was evaluated by the Framingham risk score (FRS). The prospective study included 30 patients with acromegaly (mean age 53±14 year; 16 females, 14 males; BMI 28.1±3.6 kg/m; mean±SD), 12 patients had active disease (IGF-1 751±338 &... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2407653 Fri, 15 May 2009 08:15:16 +0100 2407653 http://www.medworm.com/index.php?rid=2407652&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1202796 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1202796AbstractIn order to determine whether an α1-adrenergic mechanism is involved in the secretion of Growth Hormone (GH) in humans, we studied the effect of the α1-adrenergic-stimulating agent methoxamine on serum GH levels in twelve normal males (age range 22–32 years). Intravenous infusion of methoxamine (dose: 6 μg/kg/min; duration: 150 min) significantly reduced serum GH levels at time 120 and 150, and on integrated concentrations. These data suggest that α1-adrenergic receptors inhibit tonic GH secretion in humans.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology an... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2407652 Fri, 15 May 2009 08:15:16 +0100 2407652 http://www.medworm.com/index.php?rid=2407651&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1202850 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1202850AbstractHypothyroidism and hyperthyroidism are known to affect cholesterol metabolism, bile acid synthesis and bile content. There are previous studies reporting increased prevalence of gallstone and common bile duct stone formation in hypothyroidism. The aim of this study was to compare gallbladder (GB) motor function between euthyroid, hypothyroid and hyperthyroid subjects by conventional ultrasonography. Eighteen euthyroid, 14 hypothyroid and 20 hyperthyroid, age, sex and body mass index matched subjects were included in the study. Etiology of hypothyroidism comprised of thyroidectomy, Hashimoto's thyroiditis and previous radioactive iodine therapy. Hyperthyroid group included patients with toxic nodular goitre and Graves’ dis... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2407651 Fri, 15 May 2009 08:15:16 +0100 2407651 http://www.medworm.com/index.php?rid=2407650&cid=s_36607_15_f&fid=36607&url=http%3A%2F%2Fwww.thieme-connect.com%2FDOI%2FDOI10.1055%2Fs-0029-1215587 Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1215587AbstractThis minireview gives a clinical overview of the efficacy and of the side effects of the thyrostatic drug propylthiouracil, which is in use for the treatment of Graves’ disease for more than 5 decades. It is the aim of this minireview to give convincing evidence of the value of propythiouracil in the treatment of thyrotoxic patients with Graves’ disease: The modalities of treatment are given. The advantages in comparison to methimazole are mentioned: Especially for thyrotoxic nursing mothers it represents the only thyrostatic drug approved by the American Academy of Pediatrics. Patients who experience side effects with methimazole usually can be switched successfully to propylthiouracil and vice versa. Its use for t... Experimental and Clinical Endocrinology and Diabetes journals http://www.medworm.com/rss/comments.php?id=2407650 Fri, 15 May 2009 08:15:16 +0100 2407650