MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Fitoterapia' source. Mon, 06 Feb 2012 13:31:40 +0100 http://www.medworm.com/index.php?rid=5655075&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22285860%26dopt%3DAbstract Authors: de Vasconcellos Abdon AP, Coelho de Souza G, Noronha Coelho de Souza L, Prado Vasconcelos R, Araújo Castro C, Moreira Guedes M, Pereira Lima Júnior RC, de Azevedo Moreira R, de Oliveira Monteiro-Moreira AC, Rolim Campos A Abstract The present study was designed to verify whether frutalin (FTL) affords gastroprotection against the ethanol-induced gastric damage and to examine the underlying mechanism(s). Gastric damage was induced by intragastric administration of 0.2ml of ethanol (96%). Mice in groups were pretreated with FTL (0.25, 0.5 and 1mg/kg; i.p.), cimetidine (100mg/kg; p.o.), or vehicle (0.9% of NaCl, 10mL/kg; p.o.), 30min before ethanol administration. They were sacrificed 30min later, the stomachs excised, and the mucosal lesion area (mm(2)) measured by planime... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5655075 Sat, 21 Jan 2012 05:00:00 +0100 5655075 http://www.medworm.com/index.php?rid=5655074&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22285939%26dopt%3DAbstract Authors: Liu XG, Gao PY, Wang GS, Song SJ, Li LZ, Li X, Yao XS, Zhang ZX Abstract Antidepressant activity-guided fractionation of the MeOH extract of Valeriana fauriei Briq. roots resulted in the isolation of two new germacrane-type sesquiterpenes (1-2) in addition to seven known ones (3-9). Their structures were elucidated as 1β,10α-dihydroxyl-8α-acetoxyl-10β,11,11-trimethyl-4- formyl-bicyclogermacren-E-4(5)-ene (1), 1β-hydroxyl-8α-acetoxyl-11,11-dimethyl-4-formyl- bicyclogermacren-E-4(5),10(14)-diene (2), bicyclo[8,1,0]5β-hydroxyl-7β-acetoxyl-5α,11,11'-trimethyl -E-1(10)-ene-4α,15-olide (3), 8α-acetoxyl-3α,4α,10-trihydroxyl-guaia-1(2)-ene-12,6α-olide (4), 2-Ethylhexyl-4-hydroxybenzoate (5), 11αH-gemacra-1(10)E,4Z-diene-3-one-12,6α-olide (6), β-Sitoterol (7), isov... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5655074 Sat, 21 Jan 2012 05:00:00 +0100 5655074 http://www.medworm.com/index.php?rid=5636804&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22265800%26dopt%3DAbstract This study was aimed to elucidate the chemical characteristics of Paris fargesii var. brevipetala (PFB) that may be administrated as alternate resource of legal RP. A HPLC-ELSD method was established to characterize the steroid saponins in rhizomes of PFB and two legal Paris species [Paris polyphylla var. chinensis (PPC) and P. polyphylla var. yunnanensis (PPY)] in Chinese Pharmacopoeia (CP). Ten saponins (paris saponins I, II, V, VI, VII, H, gracillin and other three paris saponins) were involved as standards. The results indicated that PFB contained pennogenyl saponins as the main components with small amounts of diosgenin saponins. The total contents of the detected saponins in PFB ranged from 9.12mg/g to 85.33mg/g. Nine of the twelve PFB samples own a total content of paris saponins I,... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5636804 Sat, 14 Jan 2012 05:00:00 +0100 5636804 http://www.medworm.com/index.php?rid=5636803&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22266389%26dopt%3DAbstract Authors: Tang Y, Jiang W, Wu Q, Yu L, Zhang L, Tao W, Ding A, You F, Duan JA Abstract A rapid and simple method was established for the simultaneous determination of ten diterpenes by reversed phase HPLC coupled with evaporative light scattering detection. Chromatographic separation was carried out in gradient mode by using a WondaSilâ„¢ C(18) column (250mm×4.6mm, 5μm) with mobile phases of methanol and water at 1mL/min. The drift tube temperature of evaporative light scattering detector was set to 65°C and nitrogen flow-rate was 2.7L/min. The method validated was shown to be specific, precise, accurate and linear. Moreover, it was applied to investigate four samples of E. fischeriana with different extracting methods. Contrast to the dried roots, the fresh roots had much higher... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5636803 Sat, 14 Jan 2012 05:00:00 +0100 5636803 http://www.medworm.com/index.php?rid=5636802&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22266390%26dopt%3DAbstract Authors: Hussain J, Ur Rehman N, Hussain H, Al-Harrasi A, Ali L, Rizvi TS, Ahmad M, Mehjabeen Abstract Two new pentacyclic triterpenes named kirmanoic acid (1) and kurramanoic acid (2) have been isolated from the chloroform-soluble portion of the whole plant of Nepeta clarkei Hook. The structures of the two new compounds were assigned on the basis of their (1)H and (13)C NMR spectra including two-dimensional NMR techniques such as COSY, HMQC, and HMBC experiments. Kirmanoic acid (1) was investigated for analgesic, anti-inflammatory, and CNS depressant activities. Interestingly kirmanoic acid (1) showed strong analgesic activity than standard drug in acetic induced writhing and formalin tests. Similarly kirmanoic acid (1) also showed strong anti-inflammatory activity than its stand... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5636802 Sat, 14 Jan 2012 05:00:00 +0100 5636802 http://www.medworm.com/index.php?rid=5619066&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22248534%26dopt%3DAbstract In conclusion, we observed distinct compounds in fresh ginger to have biological activities relevant in diseases associated with reactive oxygen species. PMID: 22248534 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5619066 Tue, 10 Jan 2012 05:00:00 +0100 5619066 http://www.medworm.com/index.php?rid=5619074&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22245083%26dopt%3DAbstract Authors: Hernández DM, Díaz-Ruíz G, Rivero-Cruz BE, Bye RA, Aguilar MI, Rivero-Cruz JF Abstract From the roots of Iostephane heterophylla, six known compounds, namely, ent-trachyloban-19-oic acid (1), the mixture of ent-kaur-16-en-19-oic acid (2) and ent-beyer-15-en-19-oic acid (3), xanthorrhizol (4), 16α-hydroxy-ent-kaurane (5) and 16α-hydroxy-ent-kaur-11-en-19-oic acid (6) were isolated using a bioassay-guided fractionation method. The known compounds (1-6) were identified by comparison of their spectroscopic data with reported values in the literature. In an attempt to increase the resultant antimicrobial activity of 1 and 4, a series of reactions was performed on ent-trachyloban-19-oic acid (1) and xanthorrhizol (4), to obtain derivatives 1a, 1b, and 4a-4d. All the isolate... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5619074 Mon, 09 Jan 2012 05:00:00 +0100 5619074 http://www.medworm.com/index.php?rid=5619068&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22245089%26dopt%3DAbstract In this study, PEs from J. curcas oil (Jatropha factors C(1) and C(2) (purified to homogeneity), Jatropha factors C(3) and (C(4)+C(5)) (obtained as mixtures) and PE-rich extract (containing all the above stated Jatropha factors) were investigated. The concentrations of Jatropha PEs were expressed equivalent to Jatropha factor C(1). In the snail (Physa fontinalis) bioassay, the order of potency (EC(50), μg/L) was: PE-rich extract<factor C(3) mixture<factor C(2)<factor C(1)<factor (C(4)+C(5)). In the Artemia salina bioassay, the order of potency (EC(50), mg/L) was: factor C(2)<factor C(3) mixture<factor C(1)<factor (C(4)+C(5)) mixture. In addition, Jatropha PEs exhibited platelet aggregation (ED(50), μM, factor C(2)<factor C(3) mixture<factor C(1)<factor (C(4)... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5619068 Mon, 09 Jan 2012 05:00:00 +0100 5619068 http://www.medworm.com/index.php?rid=5619076&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22245081%26dopt%3DAbstract Authors: Abdel-Mageed WM, Backheet EY, Khalifa AA, Ibraheim ZZ, Ross SA Abstract A radical scavenging guided phytochemical study on the stem bark of Tecoma mollis afforded seven active phenylpropanoid glycosides (1-7), including a new one (4), and one iridoid (8). The structures of the isolated compounds were elucidated on the basis of spectroscopic evidences and correlated with known compounds. Compounds (1-7) displayed promising antioxidant activity (DPPH assay) in relation to ascorbic acid (positive control). The antimicrobial activity for compounds (1-8) was evaluated against five bacterial and five fungal strains. The isolated compounds exhibited nonselective weak to moderate antimicrobial activity. The highest antileishmanial activity against Leishmania donovani was observed ... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5619076 Sun, 08 Jan 2012 05:00:00 +0100 5619076 http://www.medworm.com/index.php?rid=5619075&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22245082%26dopt%3DAbstract Authors: Ding G, Chen L, Chen A, Tian X, Chen X, Zhang H, Chen H, Liu XZ, Zhang Y, Zou ZM Abstract Two new cytochalasans, trichalasins C (1) and D (2) together with known cytochalasans aspochalasins D (3), M (4) and P (5) were isolated from one endophytic fungus Trichoderma gamsii inhabiting in traditional medicinal plant Panax notoginseng (BurK.) F.H.Chen. The structures for the new compounds 1 and 2 were determined by NMR and HRESIMS, and their relative configurations were established by analysis of coupling constants and NOESY correlations. Compound 3 displaying inhibitory activity with EC(50) value 5.72μM, whereas the EC(50) values for compounds 1-4 are more than 40μM. PMID: 22245082 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5619075 Sun, 08 Jan 2012 05:00:00 +0100 5619075 http://www.medworm.com/index.php?rid=5619073&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22245084%26dopt%3DAbstract In this study, baicalein and baicalin were determined by LC-MS method. The chromatographic separation was performed on Agilent Poroshell 120 SB-C18 column (2.7μm, 2.1×50mm). Baicalein and baicalin were detected by single quadrupole mass spectrometer equipment with electrospray ionization interface with the selected ion monitoring mode. The assay was linear for both baicalein and baicalin with the correlation coefficients>0.99. The intra- and inter-day precisions for baicalein and baicalin were all less than 15% by relative standard deviation. The analytes were stable during samples storage and handling, and no matrix effects were observed. The method we developed in this study was sensitive, precise, stable and producible. PMID: 22245084 [PubMed - as supplied by publisher] (Source... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5619073 Sun, 08 Jan 2012 05:00:00 +0100 5619073 http://www.medworm.com/index.php?rid=5619072&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22245085%26dopt%3DAbstract The objective of this work was to verify the chemical composition and antibiotic modifying activity of the essential oil extracted from the leaves of L. sidoides and its major component thymol. The essential oil was obtained by hydrodistillation and analyzed by GC/MS. The synergistic activity was evaluated using gaseous contact method. The essential oil was obtained (yield of 1.06%) and the GC/MS analysis identified the main constituents: thymol (84.9%) and p-cymene (5.33%). The antibiotic modifying activity was verified using the minimal inhibitory dose method and gaseous contact. It verified the interference of essential oil and thymol against all tested aminoglycosides. There were no statistical differences between the activity of the essential oil and thymol against Pseudomonas aerugin... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5619072 Sun, 08 Jan 2012 05:00:00 +0100 5619072 http://www.medworm.com/index.php?rid=5619071&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22245086%26dopt%3DAbstract Authors: Xu J, Jin DQ, Zhao P, Song X, Sun Z, Guo Y, Zhang L Abstract Two new (1 and 2) and one known (3) β-dihydroagarofuran sesquiterpenes were isolated from the fruits of Celastrus orbicultus Thunb. Their structures were elucidated as 1β,13-diacetoxy-8β,9β-dibenzoyloxy-β-dihydroagarofuran (1), 1β,13-diacetoxy-8α-hydroxy-9β-benzoyloxy-β-dihydroagarofuran (2), and 1β,6α,13-triacetoxy-9α-benzoyloxy-β-dihydroagarofuran (3), on the basis of spectroscopic data analyses. All the compounds exhibited inhibitory effects on LPS-induced nitric oxide production in murine microglial BV-2 cells. PMID: 22245086 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5619071 Sun, 08 Jan 2012 05:00:00 +0100 5619071 http://www.medworm.com/index.php?rid=5619070&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22245087%26dopt%3DAbstract Authors: Yu Y, Feng XL, Gao H, Xie ZL, Dai Y, Huang XJ, Kurihara H, Ye WC, Zhong Y, Yao XS Abstract A new lignan glucoside, (+)-(7S,8R,8'R)-lyoniresinol 6″-O-trans-sinapoyl-9-O-β-d- glucopyranoside (1), and a new iridoid glucoside, 10-O-trans-sinapoylgeniposide (2), together with eight known compounds, were isolated from the fruits of Gardenia jasminoides Ellis. The structures of the isolates were elucidated by extensive spectroscopic studies, including UV, IR, 1D and 2D NMR, ESI-MS, HR-ESI-MS, and CD experiments. The short-term-memory-enhancement activities of some compounds were evaluated on an Aβ transgenic drosophila model. PMID: 22245087 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5619070 Sun, 08 Jan 2012 05:00:00 +0100 5619070 http://www.medworm.com/index.php?rid=5619069&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22245088%26dopt%3DAbstract Authors: Perrone A, Capasso A, Festa M, Kemertelidze E, Pizza C, Skhirtladze A, Piacente S Abstract Two new compounds, a furostanol glycoside (1) and a pregnane glycoside (4), along with eight known compounds, belonging to the classes of steroidal (2,3), pregnane (5-7) and cardenolide (8-10) glycosides, were isolated from the seeds of Digitalis ciliata. Their structures were elucidated by 1D and 2D-NMR experiments as well as ESI-MS analysis. For the first time pregnane glycosides of the diginigenin series have been isolated from D. ciliata. The cytotoxic effects of compounds 1-10 on cell viability of several cancer cell lines, namely human breast cancer (MCF-7), human glioblastoma (T98G), human lung adenocarcinoma (A549), human colon carcinoma (HT-29), and human prostate cancer (PC... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5619069 Sun, 08 Jan 2012 05:00:00 +0100 5619069 http://www.medworm.com/index.php?rid=5619067&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22245574%26dopt%3DAbstract This study aims to evaluate antifungal activities of longan fruit extract in comparison to its active compounds. The results showed that longan seed exhibited antifungal activity against the opportunistic yeasts (Candida species and Cryptococcus neoformans). In contrast, longan pulp and whole fruit did not demonstrate any inhibitory effects. Ellagic acid showed the most potent antifungal activity followed by corilagin and gallic acid, respectively. Ellagic acid inhibited Candida parapsilosis and C. neoformans more effectively than Candida krusei and also some Candida albicans clinical strains. Baidam cultivar possessed higher antifungal activity (MIC=500-4000μg/ml) as it contained higher contents of ellagic acid and gallic acid than Edor (MIC=1000-8000μg/ml). For antibacterial activity, ... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5619067 Sun, 08 Jan 2012 05:00:00 +0100 5619067 http://www.medworm.com/index.php?rid=5619081&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22230193%26dopt%3DAbstract Authors: Cometa MF, Fortuna S, Palazzino G, Volpe MT, Salgado ER, Nicoletti M, Tomassini L Abstract The phytochemical study of the stem bark and wood of Abuta grandifolia (Mart.) Sandwith led to the identification of four bisbenzylisoquinoline alkaloids (BBIQs), namely (R,S)-2 N-norberbamunine (1), (R,R)-isochondodendrine (2), (S-S)-O4″-methyl, Nb-nor-O6'-demethyl-(+)-curine (3), and (S-S)-O4″-methyl, O6'-demethyl-(+)-curine (4), together with the aporphine alkaloid R-nornuciferine (5), all obtained by countercurrent distribution separation (CCD) and identified on the basis of their spectroscopic data. Alkaloids 3 and 4 were new. All the isolated compounds were tested for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities. 1 was the most active a... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5619081 Fri, 30 Dec 2011 05:00:00 +0100 5619081 http://www.medworm.com/index.php?rid=5619080&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22230194%26dopt%3DAbstract Authors: Gao P, Hirano T, Chen Z, Yasuhara T, Nakata Y, Sugimoto A Abstract We previously showed that ethanolic extracts of spores of Ganoderma lucidum inhibit tumor cell proliferation and induce apoptosis of HL-60 cells. The active constituents appeared to be long-chain fatty acids, particularly carbon-19 (C-19) fatty acids which have not been reported in spores of Ganoderma lucidum. In the present study, two of these C-19 fatty acids which are key compounds in the activities, were identified as their 2-naphthyl ester derivatives after esterification of a mixture of fatty acids obtained from the spores. The active compounds were determines as nonadecanoic acid and cis-9-nonadecenoic acid. The location of the double bond of cis-9-nonadecenoic acid was demonstrated by GC-MS analysis... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5619080 Fri, 30 Dec 2011 05:00:00 +0100 5619080 http://www.medworm.com/index.php?rid=5619079&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22233862%26dopt%3DAbstract Authors: Tang W, Xu H, Zeng D, Yu L Abstract Three new phenolic constituents, itolide A (1), itolide B (2), itoside P (3), and 1D-3-deoxy-3-hydroxymethyl-myo-inositol (4), which is described herein for the first time as a natural product, were isolated along with four other known compounds (5 to 8) from the methanol extract of the seeds of Itoa orientalis Hemsl by the activity-guided fractionation. Their structures were determined by spectroscopic means. Compounds 1 to 8 exhibited antifungal activities against Sclerotium rolfsii with IC(50) values ranging from 60.12 to 240.00μM and against Rhizoctonia solani with IC(50) values ranging from 45.34 to 233.14μM, respectively, and compounds 1, 2, 5 exhibited cytotoxic activity against Tn5B1-4 insect cell line with EC(50) values of 203... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5619079 Fri, 30 Dec 2011 05:00:00 +0100 5619079 http://www.medworm.com/index.php?rid=5619078&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22233863%26dopt%3DAbstract Authors: Li XD, Miao FP, Li K, Ji NY Abstract Three new halogenated sesquiterpenes, 10-bromo-7α,8α-expoxychamigr-1-en-3-ol (1), 10-bromo-β-chamigren-8-ol (2), and 10-bromo-3-chlorocupar-5-en-2-ol (3), one new C(12)-acetogenin, desepilaurallene (7), one new naturally occurring sesquiterpene, 7-hydroxylaurene acetate (4), two known sesquiterpenes, allolaurinterol acetate (5) and laurene (6), and one known C(15)-acetogenin, epilaurallene (8), were isolated from the marine red alga Laurencia okamurai collected from the coast of Rongcheng, China. The structures of these compounds were unambiguously established by 1D, 2D NMR and mass spectroscopic techniques. The bioassay results showed that 4, 5 exhibited potent antibacterial activity, and 1, 4, 5 were toxic to brine shrimp. PMID... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5619078 Fri, 30 Dec 2011 05:00:00 +0100 5619078 http://www.medworm.com/index.php?rid=5619077&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22233864%26dopt%3DAbstract Authors: Hussain H, Ahmed I, Schulz B, Draeger S, Krohn K Abstract Four new pyrenocines, named pyrenocines J-M (1-4), were isolated from an endophytic fungus, Phomopsis sp, by a bioassay-guided method. The structures of the new compound have been assigned from (1)H and (13)C NMR spectra, DEPT, and by 2D COSY, HMQC, and HMBC experiments. Preliminary studied showed that compounds 1, 2 and 4 showed good antifungal, antibacterial, and algicidal properties, while compound 3 had good antibacterial and algicidal properties. PMID: 22233864 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5619077 Fri, 30 Dec 2011 05:00:00 +0100 5619077 http://www.medworm.com/index.php?rid=5576607&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22223143%26dopt%3DAbstract Authors: Gong Y, Liu X, He W, Xu H, Yuan F, Gao Y Abstract The influence of various solvents on the yield of polyphenols from defatted marigold residue, the antioxidant activity of the extracts and the composition of antioxidant compounds in the extracts were investigated. The content of total phenolics and flavonoids in the extracts was significantly varied with different solvents (P<0.05) and the extract by ethyl alcohol (EtOH)/water (7:3, v/v) has the highest content of total phenolics and flavonoids, 62.33mg gallic acid equivalents (GAE)/g and 97.00mg rutin equivalent (RE)/g, respectively. The antioxidant activity of the extracts was evaluated by radical (2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 1,1-diphenyl-2-picrylhydrazyl (DPPH)) scavenging and ferr... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5576607 Thu, 22 Dec 2011 05:00:00 +0100 5576607 http://www.medworm.com/index.php?rid=5557874&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22210538%26dopt%3DAbstract Authors: Wu X, Chen X, Huang Q, Fang D, Li G, Zhang G Abstract The roots of Polygonum multiflorum (Chinese name: He-Shou-Wu, HSW) are used in traditional Chinese medicine for many diseases in processed form or raw state. There are reports dealing with the toxicity of HSW. However, the toxicity is caused by over dosage or by the herb itself remains unclear. We evaluated the toxicity of raw and processed HSW on Kunming (KM) mice. For raw HSW, the toxicity of water decocta is much higher than that of acetone extract. Meanwhile, the toxicity of acetone extract of raw HSW is considerably higher than that of acetone extract of processed HSW. HPLC analyses revealed that the contents of characteristic compounds in raw HSW were changed after processing: the content of 2,3,4',5-tetrahydroxys... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5557874 Thu, 22 Dec 2011 05:00:00 +0100 5557874 http://www.medworm.com/index.php?rid=5544607&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22198559%26dopt%3DAbstract CONCLUSION: Our results suggest that black cohosh warrants further study for breast cancer prevention and therapy. PMID: 22198559 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5544607 Fri, 16 Dec 2011 05:00:00 +0100 5544607 http://www.medworm.com/index.php?rid=5544608&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22197642%26dopt%3DAbstract Authors: Tao WW, Duan JA, Yang NY, Tang YP, Liu MZ, Qian YF Abstract A new coumestan, named glycyrurol, and nine phenolic compounds were isolated from the ethyl acetate extract of the roots and rhizomes of Glycyrrhiza uralensis. Their structures were elucidated based on spectroscopic analysis and literature data, and anticoagulative assay found significant antithrombotic activity of compounds 4, 8 and 10. PMID: 22197642 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5544608 Wed, 14 Dec 2011 05:00:00 +0100 5544608 http://www.medworm.com/index.php?rid=5526082&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22183079%26dopt%3DAbstract Authors: Jiang F, Zhao Y, Wang J, Wei S, Wei Z, Li R, Zhu Y, Sun Z, Xiao X Abstract A comparative study was designed and conducted to compare the pharmacokinetic difference of paeoniflorin and albiflorin after oral administration of Radix Paeoniae Rubra to normal rats and the acute cholestasis hepatitis rats induced by alpha-naphthylisothiocyanate (ANIT). UPLC-ESI-MS/MS method was employed to determine the level of paeoniflorin and albiflorin in rat plasma using geniposide as the internal standard (IS). Unpaired Student's t-test was used for the statistical comparison. The investigation showed that there were significant differences between the normal rats and the acute cholestasis hepatitis rat groups in calculated parameters, such as AUC(0-t), AUC(0-∞), T(max) and CLz/F. The re... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5526082 Tue, 13 Dec 2011 05:00:00 +0100 5526082 http://www.medworm.com/index.php?rid=5526089&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22178679%26dopt%3DAbstract In conclusion, this study shows significant anticandidal activity of CUR and MCD against both azole-resistant and sensitive clinical isolates, MCD is found to be more effective. PMID: 22178679 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5526089 Fri, 09 Dec 2011 05:00:00 +0100 5526089 http://www.medworm.com/index.php?rid=5526088&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22178680%26dopt%3DAbstract Authors: Kumar R, Patel DK, Prasad SK, Laloo D, Krishnamurthy S, Hemalatha S Abstract Bergenin, a major constituent of Caesalpinia digyna Rottler (Leguminosae) was isolated from its roots and was characterized by comparing its melting point and spectroscopic data (IR, (1)H, (13)C, Mass Spectra) with standard bergenin. Isolated bergenin was than evaluated for antidiabetic (Type 2) activity in streptozotocin (STZ)-nicotinamide induced diabetic rats. Bergenin was administered at doses of 2.5, 5, and 10mg/kg; p.o. to normal rats which were subjected to oral glucose tolerance test (OGTT). Bergenin at same dose level was given to diabetic rats and fasting blood glucose level was estimated on 0th, 7th and 14th day of treatment while plasma lipids, antioxidant enzymes and liver glycogen le... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5526088 Fri, 09 Dec 2011 05:00:00 +0100 5526088 http://www.medworm.com/index.php?rid=5526087&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22178681%26dopt%3DAbstract Authors: Wei S, He W, Lu J, Wang Z, Yamashita K, Yokoyama M, Kodama H Abstract Five oleanolic acid triterpenoid saponins (OTS-1, 2, 3, 4 and 5) were isolated from the rhizome of Anemone raddeana. The effect of these triterpenoid saponins on stimulus-induced superoxide generation in human neutrophils was assayed by measuring the reduction of ferricytochrome c using a dual-beam spectrophotometer. The phosphorylation of neutrophil proteins, and translocation of p67(phox), p47(phox) and Rac to plasma membrane were investigated using specific monoclonal antibodies. The five oleanolic acid triterpenoid saponins used in this experiment suppressed N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide generation in a concentration-dependent manner. OTS-1, 2 and 4 suppressed phor... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5526087 Fri, 09 Dec 2011 05:00:00 +0100 5526087 http://www.medworm.com/index.php?rid=5526086&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22178682%26dopt%3DAbstract Authors: Wang JM, Ji LL, Branford-White CJ, Wang ZY, Shen KK, Liu H, Wang ZT Abstract Antitumor activities of water extract (fraction A), ethanol extract (fraction B), ethyl acetate extract (fraction C), non-ethyl acetate extract (fraction D) and compound diosbulbin B isolated from Dioscorea bulbifera L. (DB) were investigated in vivo in this present study. The results showed that fractions B and C both decreased tumor weight in S180 and H22 tumor cells bearing mice, while fractions A and D had no such effect. Furthermore, fraction C altered the weight of spleen and thymus, and the amounts of total leukocytes, lymphocytes and neutrophils in tumor-bearing mice. Further results showed that compound diosbulbin B demonstrated anti-tumor effects in the dose-dependent manner at the dosag... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5526086 Fri, 09 Dec 2011 05:00:00 +0100 5526086 http://www.medworm.com/index.php?rid=5526085&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22178683%26dopt%3DAbstract In this study, we provide evidence that black cohosh contains an unexpected and highly diverse group of secondary nitrogenous metabolites previously unknown to exist in this plant. Using a dereplication approach that combines accurate mass measurements, database searches and general knowledge of biosynthetic pathways of natural products, we identified or tentatively identified 73 nitrogen-containing metabolites, many of which are new natural products. The identified compounds belong to several structural groups including alkaloids, amides or esters of hydroxycinnamic acids and betains. Among the alkaloids, several classes such as guanidino alkaloids, isoquinolines and β-carbolines were identified. Fragmentation patterns for major compound classes are discussed, which provides a framework ... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5526085 Fri, 09 Dec 2011 05:00:00 +0100 5526085 http://www.medworm.com/index.php?rid=5526084&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22178684%26dopt%3DAbstract Authors: Wu GS, Lu JJ, Guo JJ, Li YB, Tan W, Dang YY, Zhong ZF, Xu ZT, Chen XP, Wang YT Abstract Ganoderic acid DM (GADM) is a triterpenoid isolated from Ganoderma lucidum, a well-known edible medicinal mushroom. In the present study, we found that GADM effectively inhibited cell proliferation and colony formation in MCF-7 human breast cancer cells, which was much stronger than that of MDA-MB-231 breast cancer cells. GADM both concentration- and time-dependently mediated G1 cell cycle arrest and significantly decreased the protein level of CDK2, CDK6, cycle D1, p-Rb and c-Myc in MCF-7 cells. Moreover, GADM obviously induced DNA fragmentation and cleavage of PARP which are the characteristics of apoptosis and decreased the mitochondrial membrane potential in MCF-7 cells. Besides, we... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5526084 Fri, 09 Dec 2011 05:00:00 +0100 5526084 http://www.medworm.com/index.php?rid=5526083&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22179036%26dopt%3DAbstract Authors: Maurya R, Ravi M, Singh S, Yadav PP Abstract The natural Cassane and norcassane diterpenes are biosynthetic rearrangement products of Pimarane precursor in the biosynthetic pathway of diterpenes. Their distribution is highly restricted to various genera of Fabaceae family (especially to Caesalpinia genus). A comprehensive account of the structural diversity (322 structures, 114 references) is given in this review along with biological activities of cassane and norcassane diterpenes up to August 2011. PMID: 22179036 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5526083 Fri, 09 Dec 2011 05:00:00 +0100 5526083 http://www.medworm.com/index.php?rid=5506627&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22155595%26dopt%3DAbstract Authors: Rossi YE, Canavoso L, Palacios SM Abstract Intense applications of synthetic insecticides for the control of adult Musca domestica have led to the insects developing resistance to most of them. In consequence, there is interest in new active ingredients as alternatives to conventional insecticides. Essential oils (EO) are potential tools for controlling M. domestica because of their effectiveness and their minimal environmental effects. In a fumigant assay, M. domestica adults treated with Minthostachys verticillata EO [LC(50)=0.5mg/dm(3); majority components by SPME-GC: (4R)(+)-pulegone (67.5%), menthone (22.3%) and (4R)(+)-limonene (3.8%)], died within 15min or less. The terpenes absorbed by the flies and their metabolites, analyzed using SPME fiber, were (4R)(+)-limonen... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5506627 Tue, 06 Dec 2011 05:00:00 +0100 5506627 http://www.medworm.com/index.php?rid=5506631&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22155189%26dopt%3DAbstract Authors: Cao X, Li CJ, Yang JZ, Wei BX, Yuan SP, Luo YM, Hou Q, Zhang DM Abstract Four new neolignans, wilfordiols A-D (1-4), together with five known compounds (5-9), were isolated from an aqueous extract of the dried leaves of Tripterygium wilfordii. Their structures were determined by spectroscopic methods, including 1D and 2D NMR, HRESIMS, and CD experiments. The anti-inflammation activities of compounds 1-9 were evaluated by the inhibitory effect on NO production, in vitro. PMID: 22155189 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5506631 Sun, 04 Dec 2011 05:00:00 +0100 5506631 http://www.medworm.com/index.php?rid=5506630&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22155592%26dopt%3DAbstract Authors: Zajdel SM, Graikou K, GÅ‚owniak K, Chinou I Abstract A new iridoid glucoside named 10-isovaleroyl-dihydropenstemide (1), along with nine known compounds was isolated from the aerial part of Penstemon campanulatus (Cav.) Willd. The known compounds include three iridoid glucosides, one phenylpropanoid glucoside, one monoterpene glucoside, one monoterpene lactone and three flavonoids. Their structures were elucidated on the basis of spectral evidence. Additionally four phenolic acids as well as a fatty acid were determined through GC-MS analysis. All isolated compounds and the crude extracts were assayed for their antimicrobial activities against six Gram positive and negative bacteria, as well as against three human pathogenic fungi. PMID: 22155592 [PubMed - as supplied ... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5506630 Sun, 04 Dec 2011 05:00:00 +0100 5506630 http://www.medworm.com/index.php?rid=5506629&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22155593%26dopt%3DAbstract Authors: Bystrom LM Abstract Most natural product research is market-driven and thus many plant species are overlooked for their health value due to lack of financial incentives. This may explain the limited information available about the health effects of the edible fruit species Melicoccus bijugatus, a member of the Sapindaceae family that grows mostly in the Caribbean and in parts of South America. However, recent phytochemical studies of these fruits have shed some light on their biological effects. In this review the health effects of M. bijugatus fruit pulp and seeds are assessed in relation to phytochemical and ethnobotanical studies, as well as chemotaxonomic information and medicinal uses of other Sapindaceae species. The chemistry of M. bijugatus fruits was found to be d... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5506629 Sun, 04 Dec 2011 05:00:00 +0100 5506629 http://www.medworm.com/index.php?rid=5506628&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22155594%26dopt%3DAbstract Authors: Yu SX, Yan RY, Liang RX, Wang W, Yang B Abstract Two new phenylethanoid glycosides magnoloside D (1) and E (2), together with nine known compounds, were isolated from the polar part of methanol extract of the stem bark of Magnolia officinalis. The structures of the new compounds were established on the basis of spectral analysis. Anti-spasmodic activity of four major constituents (3, 4, 9 and 11) was tested in isolated colon of rat, compounds 3, 4, and 9 showed inhibition against acetylcholine, with the effect similar to that of magnolol and honokiol. At the same time, antioxidant activity of the isolated compounds was investigated using a DPPH and an ORAC assay. All of the compounds, except compound 8 showed potent antioxidant capacity in the ORAC assay, while compounds 1... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5506628 Sun, 04 Dec 2011 05:00:00 +0100 5506628 http://www.medworm.com/index.php?rid=5506626&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22155596%26dopt%3DAbstract Authors: Senejoux F, Demougeot C, Kerram P, Aisa HA, Berthelot A, Bévalot F, Girard-Thernier C Abstract Ziziphora clinopodioides Lam. (Lamiaceae) is traditionally used in Uighur's medicine for the treatment of hypertension. Our study determined and evaluated the bioactive compounds by performing an activity-guided fractionation of a hydroalcoholic extract of the whole plant, using an in vitro model of rat isolated thoracic aortic rings. Seven compounds were identified as active principles: acacetin, apigenin, chrysin, thymonin, acetovanillone, 4-hydroxyacetophenone and ethyl 4-coumarate. Apigenin, chrysin and ethyl 4-coumarate were found to be the most effective. Our results provide the first evidence that the vasodilation induced by Z. clinopodioides Lam. is mediated, at least in... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5506626 Sun, 04 Dec 2011 05:00:00 +0100 5506626 http://www.medworm.com/index.php?rid=5506625&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22166397%26dopt%3DAbstract In this study, we examined whether M. cordata extract and/or its major alkaloid constituents, protopine, allocryptopine, sanguinarine and chelelerythrine activate the Nrf2 signalling pathway which regulates the expression of cytoprotective enzymes including heme oxygenase-1 (HO-1) and thioredoxin 1. In murine macrophage RAW264.7 cells, M. cordata extract increased both mRNA and protein levels of HO-1. Of the alkaloids examined, only sanguinarine appeared to be responsible for these effects. At the concentration of 2μM, sanguinarine induced nuclear accumulation of Nrf2, increased the expression of Hmox1 gene encoding HO-1 and elevated HO-1 protein levels. Sanguinarine-induced Hmox1 mRNA expression was suppressed by SB203580, a pharmacologic inhibitor of p38 mitogen-activated protein kinase... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5506625 Sun, 04 Dec 2011 05:00:00 +0100 5506625 http://www.medworm.com/index.php?rid=5506635&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22155186%26dopt%3DAbstract Authors: Kongkum N, Tuchinda P, Pohmakotr M, Reutrakul V, Piyachaturawat P, Jariyawat S, Suksen K, Yoosook C, Kasisit J, Napaswad C Abstract Four new flavones, 5,2'-dihydroxy-7,3',4',5'-tetramethoxyflavone (1), 5,2',5'-trihydroxy-7,3',4'-trimethoxyflavone (2), 5,7,2',5'-tetrahydroxy-6,3',4'-trimethoxyflavone (3) and 5,2',5'-trihydroxy-6,7,3',4'-tetramethoxyflavone (4), along with the known 5,3'-dihydroxy-6,7,4',5'-tetramethoxyflavone (5) 5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone (6), syringaldehyde, vanillic acid and scopoletin were isolated from the leaves and twigs of Gardenia carinata (Rubiaceae). Their structures were determined by spectroscopic methods. Flavone 2 exhibited cytotoxic activity against P-388 and MCF-7 cell lines, while 3, 5 and 6 were active only in P-388 cell... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5506635 Sat, 03 Dec 2011 05:00:00 +0100 5506635 http://www.medworm.com/index.php?rid=5506633&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22155187%26dopt%3DAbstract In conclusion, TFmix is an economic natural product preparation containing high content of theaflavins with potent anti-HIV-1 activity by targeting the viral entry step through the disruption of gp41 6-HB core structure. It has a potential to be developed as a safe and affordable topical microbicide for preventing sexual transmission of HIV. PMID: 22155187 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5506633 Sat, 03 Dec 2011 05:00:00 +0100 5506633 http://www.medworm.com/index.php?rid=5506632&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22155188%26dopt%3DAbstract Authors: Yarmolinsky L, Huleihel M, Zaccai M, Ben-Shabat S Abstract Crude ethanol extracts from Ficus benjamina leaves strongly inhibit Herpes Simplex Virus 1 and 2 (HSV-1/2) as well as Varicella Zoster Virus (VZV) cell infection in vitro. Bioassay-guided fractionation of the crude extract demonstrated that the most efficient inhibition of HSV-1 and HSV-2 was obtained with the flavonoid fraction. The present study was aimed to further isolate, purify and identify substances with potent antiviral activity from the flavonoid fraction of F. benjamina extracts. Flavonoids were collected from the leaf ethanol extracts through repeated purification procedure and HPLC analysis. The antiviral activity of each substance was then evaluated in cell culture. Three known flavone glycosides, (1)... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5506632 Sat, 03 Dec 2011 05:00:00 +0100 5506632 http://www.medworm.com/index.php?rid=5472083&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22119763%26dopt%3DAbstract Authors: Liu CX, Guo ZY, Xue YH, Cheng J, Huang NY, Zhou Y, Cheng F, Zou K Abstract Five new furostanol saponins (1-5), together with three known compounds (6-8) were obtained from the n-butanol soluble fraction of ethanol extract from Tupistra chinensis. Their structures were determined on the basis of chemical methods and spectral data. The isolated compounds were tested in vitro for their cytotoxic activities against the A549, HepG 2 and Caski cancer cell lines. Among them, compounds 6, 7, and 8 showed cytotoxicity against A549 cancer cell lines with IC(50) values of 6.6, 6.7 and 29.1μM, respectively. PMID: 22119763 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5472083 Sun, 20 Nov 2011 05:00:00 +0100 5472083 http://www.medworm.com/index.php?rid=5472081&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22120500%26dopt%3DAbstract Authors: Prashar A, Siddiqui F, Singh AK Abstract Isothiocyanates (ITCs), the breakdown products of glucosinolates found primarily in species of Brassicaceae (Cruciferae), are potential anti-cancer compounds. This review compiles data on how through different modes of action ITCs and their synthetic counterparts target leukemia. PMID: 22120500 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5472081 Sun, 20 Nov 2011 05:00:00 +0100 5472081 http://www.medworm.com/index.php?rid=5472080&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22120501%26dopt%3DAbstract Authors: Li W, Huang X, Yang XW Abstract Three new sesquiterpenoids, 1α-(3″-ethyl-cis-crotonoyloxy)-8-angeloyloxy-3β,4β-epoxy-bisabola-7(14),10-diene (1), 7β-angeloyloxy-14-hydroxy-notonipetranone (2) and 1α-hydroxy-7β-(4-methylsenecioyloxy)-oplopa-3(14)Z,8(10)-dien-2-one (3) were isolated from ethanolic extract of the dried flower buds of Tussilago farfara L., along with nine known sesquiterpenoids (4-12). All of these compounds were evaluated for their effect on the inhibition of nitric oxide (NO) production induced by lipopolysaccharide in macrophage cell line RAW 264.7 and exhibited inhibitory activity on NO production in a dose-dependent manner. 7β-(4-Methylsenecioyloxy)-oplopa-3(14)E,8(10)-dien-2-one (8) was proved to be the best among these tested sesquiterpenoids w... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5472080 Sun, 20 Nov 2011 05:00:00 +0100 5472080 http://www.medworm.com/index.php?rid=5472084&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22119096%26dopt%3DAbstract Authors: Mollataghi A, Coudiere E, Hadi AH, Mukhtar MR, Awang K, Litaudon M, Ata A Abstract Phytochemical investigation of Beilschmiedia alloiophylla has resulted in the isolation of one new alkaloid, 2-hydroxy-9-methoxyaporphine (1), and ten known natural products, laurotetanine (2), liriodenine (3), boldine (4), secoboldine (5), isoboldine (6), asimilobine (7), oreobeiline (8), 6-epioreobeiline (9), β-amyrone (10), and (S)-3-methoxynordomesticine (11). Chemical studies on the bark of Beilschmiedia kunstleri afforded compounds 2 and 4 along with one bisbenzylisoquinoline alkaloid, N-dimethylphyllocryptine (12). Structures of compounds 1-12 were elucidated on the basis of spectroscopic methods. All of these isolates were evaluated for their anti-acetylcholinesterase (AChE), anti-Î... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5472084 Thu, 17 Nov 2011 05:00:00 +0100 5472084 http://www.medworm.com/index.php?rid=5472082&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22119765%26dopt%3DAbstract Authors: Li LQ, Li J, Huang Y, Wu Q, Deng SP, Su XJ, Yang RY, Huang JG, Chen ZZ, Li S Abstract Three new lignans, erythro-strebluslignanol (1), threo-7'-methoxyl strebluslignanol (2) and erythro-7'-methoxyl strebluslignanol (3), together with twelve known compounds were isolated from the n-butanol and chloroform fractions of the heartwood of Streblus asper. Their structures were elucidated through extensive spectroscopic methods, including MS and 2D NMR experiments (HMQC and HMBC). The stereochemistry at the chiral center was determined using CD spectra, as well as analysis of coupling constants and optical rotation data, respectively. Primary bioassays showed that 6-hydroxyl-7-methoxyl-coumarin (5) and ursolic acid (10) showed anti-HBV activities, with IC(50) values of 29.60μM an... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5472082 Thu, 17 Nov 2011 05:00:00 +0100 5472082 http://www.medworm.com/index.php?rid=5452978&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22101070%26dopt%3DAbstract Authors: Kedzierska M, Olas B, Wachowicz B, Glowacki R, Bald E, Czernek U, SzydÅ‚owska-Pazera K, Potemski P, Piekarski J, Jeziorski A Abstract Since the extract from berries of Aronia melanocarpa presents antioxidative properties in plasma and in blood platelets, not only from healthy group, but also from patients with benign breast diseases and in patients with invasive breast cancer before surgery, the aim of our present study was to evaluate the oxidative stress by measuring the level of various biomarkers of this process such as the generation of superoxide anion radicals (O(2)(-)), the amount of carbonyl groups and 3-nitrotyrosine in proteins or the amount of glutathione in blood platelets isolated from breast cancer patients after the surgery and after various phases of the c... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5452978 Sat, 12 Nov 2011 05:00:00 +0100 5452978 http://www.medworm.com/index.php?rid=5452984&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22088496%26dopt%3DAbstract Authors: Kumar R, Saha A, Saha D Abstract A new γ-lactone coumarin, named as excavarin-A, showing antifungal activity was isolated from the leaves of Clausena excavata by bioassay guided fractionation method. The structure was elucidated by spectroscopic data analysis and identified as 7((2E)-4(4,5-dihydro-3-methylene-2-oxo-5-furanyl)-3-methylbut-2-enyloxy) coumarin. Minimum inhibitory concentration (MIC) was determined against fifteen fungal strains pathogenic against plants and human. The least MIC was recorded against the human pathogen, Candida tropicalis and the plant pathogens Rhizoctonia solani and Sclerotinia sclerotiorum. Antifungal activities against the human pathogens, Aspergillus fumigatus and Mucor circinelloides and plant pathogens, Colletotrichum gloeosporioides, L... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5452984 Thu, 10 Nov 2011 05:00:00 +0100 5452984 http://www.medworm.com/index.php?rid=5452983&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22088497%26dopt%3DAbstract Authors: Bi L, Tian X, Dou F, Hong L, Tang H, Wang S Abstract Four new oleanane type triterpenoid saponins (1-4) and a known saponin (5) were isolated from the root bark of Aralia taibaiensis Z.Z. Wang et H.C. Zheng. The structures of the four new compounds were elucidated as 3-O-{β-d-glucopyranosyl-(1→2)-[β-d-glucopyranosyl-(1→3)]-β-d-glucurono-pyranosyl}-olean-11,13(18)-diene-28-oic acid 28-O-β-d-glucopyranosyl ester (1), 3-O-{β-d-gluco-pyranosyl-(1→3)-[α-l-arabinofuranosyl-(1→4)]-β-d-glucuronopyranosyl}-olean-11,13(18)-diene-28-oic acid 28-O-β-D-glucopyranosyl ester (2), 3-O-{β-d-glucopyranosyl-(1→2)-[α-l-arabinofuranosyl-(1→4)]-β-d-glucuronopyranosyl}-oleanolic acid 28-O-β-D-glucopyranosyl ester (3) and 3-O-{β-d-glucopyranosyl-(1→2)-[β-d-glucopyranos... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5452983 Wed, 09 Nov 2011 05:00:00 +0100 5452983 http://www.medworm.com/index.php?rid=5452981&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22100376%26dopt%3DAbstract Authors: Li XN, Lei C, Yang LM, Li HM, Huang SX, Du X, Pu JX, Xiao WL, Zheng YT, Sun HD Abstract Three new arylnaphthalene lignans, named sinensisins A-C (1-3), together with three known compounds, were isolated from the aerial parts of Schisandra propinqua var. sinensis. Their structures were established by spectroscopic methods, and compound 1 exhibited weak anti-HIV-1 activity with an TI value of 6.7. PMID: 22100376 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5452981 Wed, 09 Nov 2011 05:00:00 +0100 5452981 http://www.medworm.com/index.php?rid=5452980&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22100836%26dopt%3DAbstract Authors: Boudjelal A, Henchiri C, Siracusa L, Sari M, Ruberto G Abstract Marrubium vulgare (Lamiaceae) is a plant traditionally used for the treatment of diabetes in Algeria. Compositional analysis of the aqueous infusion revealed the presence of fifteen metabolites, all belonging to the class of polyphenols. Particularly, seven flavonoids have been detected, together with 5-caffeoylquinic (chlorogenic) acid in small amounts; the extract is dominated by the presence of a series of complex molecules, characterized as verbascoside (acteoside) derivatives. Concerning the anti-diabetic effectiveness a series of in vivo experiments were carried out on albinos Wistar rats. Diabetes was induced in the animals by intra-peritoneal injection of alloxane; they were treated twice a day with aq... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5452980 Wed, 09 Nov 2011 05:00:00 +0100 5452980 http://www.medworm.com/index.php?rid=5452979&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22100837%26dopt%3DAbstract Authors: Nian Y, Wang HY, Su J, Zhou L, Qiu MH Abstract A new 4α-methyl sterol, cimisterol A (1), together with five known compounds (2-6), were isolated from the aerial parts of Cimicifuga foetida L. The new compound's structure was determined with the help of extensive 1D and 2D NMR spectroscopy. Compound 1 exhibited broad-spectrum and potent cytotoxic activities against human HL-60, Jurkat, K562, U937, HepG-2, and SGC-7091 cell lines, with IC(50) values of 7.23, 2.89, 6.88, 3.38, 4.21, and 4.89μM, respectively. Compound 3 showed moderate to weak activities to all cell lines, except for SGC-7091, having IC(50) values ranging from 13.37 to 17.72μM. This is the first time a cytotoxic 4α-methyl sterol constituent was discovered from Cimicifuga spp. PMID: 22100837 [PubMed - a... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5452979 Wed, 09 Nov 2011 05:00:00 +0100 5452979 http://www.medworm.com/index.php?rid=5452985&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22085765%26dopt%3DAbstract Authors: Li HE, Qiu JZ, Yang ZQ, Dong J, Wang JF, Luo MJ, Pan J, Dai XH, Zhang Y, Song BL, Deng XM Abstract In the present study, the antimicrobial activity of glycyrrhetinic acid (GA) against Staphylococcus aureus, and its influence on the production of S. aureus alpha-haemolysin (Hla) were investigated, along with the in vivo activity of GA against S. aureus-induced pneumonia. GA could not inhibit the growth of S. aureus, but the secretion of Hla by S. aureus was significantly inhibited by low concentrations of GA in a dose-dependent manner. Furthermore, in vivo data show that GA provides protection against staphylococcal pneumonia in a murine model system. PMID: 22085765 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5452985 Mon, 07 Nov 2011 05:00:00 +0100 5452985 http://www.medworm.com/index.php?rid=5452982&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22093753%26dopt%3DAbstract Authors: Tan HP, Wong DZ, Ling SK, Chuah CH Abstract The galloylated cyanogenic glucosides based on prunasin (1-7), gallotannins (8-14), ellagitannins (15-17), ellagic acid derivatives (18, 19) and gallic acid (20) isolated from the leaves of Phyllagathis rotundifolia (Melastomataceae) were investigated for their neuroprotective activity against hydrogen peroxide (H(2)O(2))-induced oxidative damage in NG108-15 hybridoma cell line. Among these compounds, the gallotannins and ellagitannins exhibited remarkable neuroprotective activities against oxidative damage in vitro as compared to galloylated cyanogenic glucosides and ellagic acid derivatives in a dose-dependent manner. They could be explored further as potential natural neuroprotectors in various remedies of neurodegenerative di... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5452982 Mon, 07 Nov 2011 05:00:00 +0100 5452982 http://www.medworm.com/index.php?rid=5412172&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22061660%26dopt%3DAbstract In this study, we showed that Rd stimulates osteoblastic differentiation and mineralization, manifested by the up-regulation of differentiation markers (alkaline phosphatase and osteogenic genes) and von Kossa/Alizarin Red staining, respectively. Rd induces the mRNA expression of bone morphogenetic protein-2 (BMP-2) and the secretion of the corresponding protein into media in a concentration-dependent manner. The mRNA expression and enzyme activity of alkaline phosphatase (ALP) were suppressed when MC3T3-E1 cells were exposed to noggin, a BMP-2 antagonist. The level of phosphorylated AMP-activated protein kinase (pAMPK) protein was also up-regulated by Rd in a time- and concentration-dependent manner. Rd-induced ALP activity, mineralization, and BMP-2 production were all inhibited by eithe... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5412172 Sat, 29 Oct 2011 04:00:00 +0100 5412172 http://www.medworm.com/index.php?rid=5412173&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22061659%26dopt%3DAbstract Authors: Wijesinghe WA, Jeon YJ Abstract Over the years, the biological activities of seaweeds could have gained a considerable research interest because of their specific functional compounds, which may not be available in land plants. Thus, efforts at discovery of novel metabolites from seaweeds over the past years have yielded a considerable amount of new active compounds. In addition, studies about the extraction of active compounds from natural products have attracted special attention in last recent years. Potent biologically active compounds of seaweeds have been demonstrated to play a significant role in prevention of certain degenerative diseases such as cancer, inflammation, arthritis, diabetic and hypertension. Therefore, seaweed derived active components, whose immense ... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5412173 Fri, 28 Oct 2011 04:00:00 +0100 5412173 http://www.medworm.com/index.php?rid=5412171&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22061661%26dopt%3DAbstract Authors: Chen Y, Wu Y, Wang H, Gao K Abstract A new compound, namely, 9-nor-atractylodin (1) and one known atractylodin (2) were isolated from the rhizomes of Atractylodes lancea. The structural modifications of atractylodin were carried out and a series of atractylodin derivatives (3-10) were obtained. The antibacterial activities of 1-10 were examined against Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Candida albicans. Compounds 4 and 8, which contained the α, β-unsaturated carbonyl fragment, were found to be active against E. coli and S. aureus. PMID: 22061661 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5412171 Fri, 28 Oct 2011 04:00:00 +0100 5412171 http://www.medworm.com/index.php?rid=5412170&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22061662%26dopt%3DAbstract Authors: Wang QX, Bao L, Yang XL, Guo H, Yang RN, Ren B, Zhang LX, Dai HQ, Guo LD, Liu HW Abstract Two new polyketides, 7-hydroxy-3, 5-dimethyl-isochromen-1-one (1) and 6-hydroxy-8-methoxy-3a-methyl-3a,9b-dihydro-3H-furo[3,2-c]isochromene-2,5-dione (2), along with eleven known compounds, 5'-methoxy-6-methyl-biphenyl-3,4,3'-triol (3), 7-hydroxy-3-(2-hydroxy-propyl)-5-methyl-isochromen-1-one (4), rubralactone (5), isoaltenuene (6), altenuene (7), dihydroaltenuenes A (8), altenusin (9), alterlactone (10), 6-O-methylnorlichexanthone (11), norlichexanthone (12), and griseoxanthone C (13) were isolated from the culture of the endolichenic fungus Ulocladium sp. Compound 2 was obtained as a racemate with an unprecedented chemical skeleton. The NMR data assignments for 3 and 4 were achieved... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5412170 Fri, 28 Oct 2011 04:00:00 +0100 5412170 http://www.medworm.com/index.php?rid=5412169&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22062354%26dopt%3DAbstract Authors: Ramsay KS, Ali Z, Khan A, Oluyemisi OO, Marasini BP, Khan IA, Bonaventure NT, Choudhary MI, Atta-Ur-Rahman , Wafo P Abstract Phytochemical investigation of the stem bark of Stereospermum acuminatissimum K. Schum. resulted in the isolation of 21 compounds, including two new guanine derivatives, 1,3,7-trimethylguanin-1/3-ium (1) and 3,7-dimethylguanin-1/3-ium (2), and one new phenolic long chain ester, 4-hydroxyphenethyl hentriacontanoate (3). The known compounds were identified as sterequinones A, F, and H (4, 5, and 6), zenkequinones A-B (7-8), p-coumaric acid (9), methyl caffeate (10), caffeic acid (11), psilalic acid (12), syringaldehyde (13), norviburtinal (14), specioside (15), verminoside (16), tyrosol (17), eutigoside A (18), ellagic acid (19), atranorin (20), and ur... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5412169 Fri, 28 Oct 2011 04:00:00 +0100 5412169 http://www.medworm.com/index.php?rid=5412175&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22056663%26dopt%3DAbstract Authors: Balsevich JJ, Ramirez-Erosa I, Hickie RA, Dunlop DM, Bishop GG, Deibert LK Abstract Total methanolic extracts of Saponaria vaccaria seed derived from several varieties, as well as various purified components obtained through successive chromatographic separations of total extracts were evaluated for their growth inhibitory activity in WiDr (colon), MDA-MB-231 (breast), NCI-417 (lung) and PC-3 (prostate) human cancer cells as well as the non-tumorigenic fibroblast BJ (CRL-2522) cell line using MTT colorimetric assay. Purified bisdesmosidic saponins segetoside H and I were further examined using microscopy and apoptosis assays. Bisdesmosidic saponins exhibited dose-dependent growth inhibitory and selective apoptosis-inducing activity. Growth inhibitory effects were particula... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5412175 Tue, 25 Oct 2011 04:00:00 +0100 5412175 http://www.medworm.com/index.php?rid=5412174&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22056666%26dopt%3DAbstract Authors: Li W, Zhang M, Gu J, Meng ZJ, Zhao LC, Zheng YN, Chen L, Yang GL Abstract Compound K (CK) is a final intestinal metabolite of protopanaxadiol-type ginsenosides (PDG) from Panax ginseng. Although anti-diabetic activity of CK have been reported with genetic mouse models (db/db mice) in recent years, the therapeutic usefulness of CK and PDG in type 2 diabetes, a more prevalent form of diabetes, remains unclear. In the present investigation, we developed a mouse of non-insulin-dependent diabetes mellitus that closely simulated the metabolic abnormalities of the human disease. For this purpose, type 2 diabetes was induced in male ICR mice by combining of streptozotocin. The male ICR mice fed with HFD for 4weeks received 100mg/kg of STZ injected intraperitoneally. After 4weeks, ... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5412174 Tue, 25 Oct 2011 04:00:00 +0100 5412174 http://www.medworm.com/index.php?rid=5376801&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22040904%26dopt%3DAbstract Authors: Wu X, Ruan J, Yang VC, Wu Z, Lou J, Duan H, Zhang J, Zhang Y, Guo D Abstract Three new acetylated benzyl-beta-resorcylate glycosides (1-3) were isolated from seeds of Cassia obtusifolia. Their structures were determined on the basis of the spectroscopic methods and physicochemical properties as 2-benzyl-4,6-dihydroxy benzoic acid-6-O-[2,6-O-diacetyl]-d-glucopyranoside (1), 2-benzyl-4,6-dihydroxy benzoic acid-6-O-[3,6-O-diacetyl]-d-glucopyranoside (2) and 2-benzyl-4, 6-dihydroxy benzoic acid-6-O-[4,6-O-diacetyl]-d-glucopyranoside (3), respectively. PMID: 22040904 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5376801 Tue, 25 Oct 2011 04:00:00 +0100 5376801 http://www.medworm.com/index.php?rid=5376804&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22037567%26dopt%3DAbstract Authors: Feng S, Hao J, Xu Z, Chen T, Qiu SX Abstract A rare naturally-occurring polyprenylated isoflavanone, designated ormosinol (1), and a new isoflavonoid glycoside, named ormosinoside (2), along with 21 known compounds were isolated from the root bark of Ormosia henryi Prain. The structures of compounds 1 and 2 were determined as 5,7,2',4'-tetrahydroxyl-6,8,5'-tri-(γ,γ-dimethylallyl)isoflavanone and isoprunetin-7-O-β-d-xylopyranosyl-(1 → 6)-β-d-glucopyranoside on the basis of a combination of 1D-, 2D-NMR and mass spectroscopic measurements. Compound 1 showed significant anti-oxidation activity against DPPH radicals (IC(50) 28.5μM) and cancer cell line (A549, LAC, and HepG2) growth inhibitory activity with IC(50) ranging from 4.25 to 7.09μM, while compound 2 found to be... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5376804 Mon, 24 Oct 2011 04:00:00 +0100 5376804 http://www.medworm.com/index.php?rid=5376803&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22037568%26dopt%3DAbstract Authors: Yang ZD, Duan DZ Abstract Pingbeimunone A (1), a new compound, together with the known ussuriedine (2), benzo[7,8]fluoreno[2,1-b]quinolizine cevane-3,6,16,20-tetrol (3), ebeiedinone (4), pingbeimine C (5) and verticine (6) were isolated from Fritillaria ussuriensis. The structure was elucidated on the basis of spectral analysis (IR, NMR and MS spectroscopy). In addition, their AChE inhibitory activities were also tested. PMID: 22037568 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5376803 Fri, 21 Oct 2011 04:00:00 +0100 5376803 http://www.medworm.com/index.php?rid=5376802&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22037569%26dopt%3DAbstract Authors: Xu SF, Zou B, Yang J, Yao P, Li CM Abstract Persimmon proanthocyanidin was fractionated on Toyopearl TSK-HW-50-F to yield a fraction with strong inhibition on the catalytic activity and edema-inducing activity and lethality of Chinese cobra PLA(2). Thiolysis suggested that the terminal units included C, EGCG and myricetin, and epicatechin, epigallocatechin, (epi)gallocatechin-3-O-gallate, and (epi)catechin-3-O-gallate occurred as extender units. The mean degree of polymerization was 23.7 MALDI TOF/MS, thioly-HPLC, FTIR and circular dichroism (CD) analyses showed that the fraction had high prodelphinidin content (55%) and a very high degree of 3-O-galloylation (92%). A type linkage is dominant in it and it had 4β linkage of the flavanyl substituent and 4R absolute configur... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5376802 Thu, 20 Oct 2011 04:00:00 +0100 5376802 http://www.medworm.com/index.php?rid=5376806&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22024633%26dopt%3DAbstract Authors: Kirmizibekmez H, Ariburnu E, Masullo M, Festa M, Capasso A, Yesilada E, Piacente S Abstract From the MeOH extract of Sideritis trojana, a new iridoid glycoside, 10-O-(E)-feruloylmelittoside (1) was obtained in addition to four known iridoid glycosides [melittoside (2), 10-O-(E)-p-coumaroylmelittoside (3), stachysosides E (4) and G (5)]. Moreover, five phenylethanoid glycosides [verbascoside (6), isoacteoside (7), lamalboside (8), leonoside A (9), isolavandulifolioside (10), three flavone glycosides (isoscutellarein 7-O-[6‴-O-acetyl-β-allopyranosyl-(1→2)]-β-glucopyranoside (11), 4'-O-methyisoscutellarein 7-O-[6‴-O-acetyl-β-allopyranosyl-(1→2)]-β-glucopyranoside (12), 3'-hydroxy-4'-O-methyisoscutellarein 7-O-[6‴-O-acetyl-β-allopyranosyl-(1→2)]-β-glucopyrano... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5376806 Sat, 15 Oct 2011 04:00:00 +0100 5376806 http://www.medworm.com/index.php?rid=5376805&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22037422%26dopt%3DAbstract Authors: Khan MF, Dixit P, Jaiswal N, Tamrakar AK, Srivastava AK, Maurya R Abstract Phytochemical investigation of the ethanolic extract of twig of Kigelia pinnata DC. afforded one new iridoid 7-hydroxy eucommiol (1), and nine known compounds (2-10). The structure of compounds was elucidated by extensive spectroscopic methods, including 1D, 2D NMR experiments and MS analysis. All these compounds were evaluated for GLUT4 translocation modulatory effect in skeletal muscle cells. Four of the tested compounds 1, 5, 6 and 7 showed significant stimulation of GLUT4 translocation to cell surface in skeletal muscle cells without any adverse effect on cell viability. Effect of these four compounds was concentration-dependent and comparable to standard drug rosiglitazone. These findings indic... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5376805 Sat, 15 Oct 2011 04:00:00 +0100 5376805 http://www.medworm.com/index.php?rid=5341885&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22008604%26dopt%3DAbstract Authors: Xiao F, Li Q, Liang K, Zhao L, He B, Ji W, Chen X, Wang Z, Bi K, Jia Y Abstract A sensitive liquid chromatographic-mass spectrometric technique coupled with liquid-liquid extraction method was developed and validated for simultaneous determination of dehydro-tumulosic acid, tumulosic acid and polyporic acid C in rat plasma. The analytes were separated on a Kromasil C(18) column with a total running time of 12.5min. Author had compared the pharmacokinetics of dehydro-tumulosic acid, tumulosic acid and polyporic acid C after oral administration of the extract of Poria and its formulated herbal preparation (GuiZhi-FuLing capsule). The improved pharmacokinetic profiles of the three compounds were found in the GuiZhi-FuLing capsule, indicating the more effective absorption and ... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5341885 Mon, 10 Oct 2011 04:00:00 +0100 5341885 http://www.medworm.com/index.php?rid=5341887&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22004725%26dopt%3DAbstract Authors: Soni VK, Yadav DK, Bano N, Dixit P, Pathak M, Maurya R, Sahai M, Jain SK, Misra-Bhattacharya S Abstract Annona squamosa (AS) has traditionally been used as ethnomedicine. We have earlier extracted and fractionated the twigs of AS based upon its bioactivity and observed its immune potentiating activity that was localized in its three fractions. Present communication deals with the phytochemical analysis and pharmacological investigation of the most active chloroform fraction that led to isolation and identification of a number of compounds whose structures were elucidated using 1D and 2D NMR spectroscopic analysis. Amongst the twelve pure compounds isolated, five compounds Lanuginosine (1), (+) -O- methylarmepavine (2), (+)-anomuricine (3), Isocorydine (4), and N-methyl-6, ... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5341887 Sat, 08 Oct 2011 04:00:00 +0100 5341887 http://www.medworm.com/index.php?rid=5341886&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22004726%26dopt%3DAbstract Authors: Rao AS, Ramesh D, Merugu R, Sreenivasulu B, Rao JM Abstract New icetexane diterpenes (1-2); 8, 11, 13-icetexatriene-10-hydroxy, 11, 12, 16-tri acetoxyl (1) and 8, 11, 13-icetexatriene-7, 10, 11-dihydroxy-12, 13-dihydrofuran (2) along with six known compounds namely acetoxy syranzaldehyde (3), syranzaldehyde (4), coniferaldehyde (5), lupeol (6), betulin (7), and 4-(4-methoxy phenyl)-2-butanone (8) were isolated from the roots of Premna tomentosa. The structures of compounds 1 and 2 were established by detailed spectral analysis using UV, IR, (1)H NMR, (13)C NMR, 1D, 2D and Mass. The newly isolated compounds were screened for rat intestinal α-glucosidase inhibitory and free radical (DPPH) scavenging potentiality. The new icetexane diterpenes (1, 2) and compound 3 were found... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5341886 Sat, 08 Oct 2011 04:00:00 +0100 5341886 http://www.medworm.com/index.php?rid=5341889&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21983344%26dopt%3DAbstract Authors: Zhang Y, Cao Y, Duan H, Wang H, He L Abstract Augmented endothelial nitric oxide (NO) synthase (eNOS) signaling has been reported to be associated with improvements in cardiac remodeling, and NO levels have been shown to be related to cardiac hypertrophy and heart failure. Imperatorin, a dietary furanocoumarin, has been shown to prevent cardiac hypertrophy in the spontaneous hypertension rats (SHR). Thus, we aimed to clarify whether imperatorin attenuates both cardiac hypertrophy and heart failure via the NO-signaling pathway. In neonatal mouse cardiac myocytes, imperatorin inhibited protein synthesis stimulated by either isoproterenol or phenylephrine, which was unchanged by NG-nitro-L-arginine methyl ester (L-NAME). Four weeks after transverse aortic constriction (TAC) o... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5341889 Sat, 24 Sep 2011 04:00:00 +0100 5341889 http://www.medworm.com/index.php?rid=5341888&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21983345%26dopt%3DAbstract Authors: Lin CZ, Zhu CC, Zhao ZX, Li XH, Xiong TQ, Xia YY, Ning Y Abstract Previous studies revealed that diterpenoids from Callicarpa genus were mainly of clerodane-type and phyllocladane-type, and abietane-type diterpenoids were seldom reported. In this paper, we reported two new abietane diterpenoids, kochianic acid A (1) and kochianic acid B (2), together with two known abietane-type diterpenoids, pedunculatic acid B (3) and 7α, 15-dihydroxydehydroabietic acid (4), which were all isolated from Callicarpa kochiana. The structures of the new compounds 1 and 2 were elucidated on the basis of extensive spectroscopic analysis, including HSQC, HMBC, (1)H-(1)H COSY, ROESY and finally confirmed by single-crystal X-ray diffraction. PMID: 21983345 [PubMed - as supplied by publisher]... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5341888 Sat, 24 Sep 2011 04:00:00 +0100 5341888 http://www.medworm.com/index.php?rid=5294045&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21968060%26dopt%3DAbstract Authors: Hu J, Shi X, Chen J, Huang H, Zhao C Abstract Four new taraxerane triterpenoids, 1β,3β-dihydroxy-11α,12α-oxidotaraxerane (1), 28-hydroxy-11α,12α-oxidotaraxerane-3-one (2), 3β-hydroxy-11α,12α-oxidotaraxerane-28-al (3), and 3-O-acetyl-11α,12α-oxidotaraxerane-28-al (4), together with three known compounds 3β-hydroxy-11α,12α-oxidotaraxerane (5), 3β,28-dihydroxy-11α,12α-oxidotaraxerane (6), and 11α,12α-oxidotaraxerane-3-one (7), were isolated from the 70% EtOH extract of Saussurea graminea. Their structures were elucidated on the basis of extensive 1D and 2D NMR (COSY, HMQC, HMBC and NOESY) analyses. The isolated compounds were evaluated in vitro for cytotoxic properties against eight tumor cell lines (A-549, BGC-823, HCT15, HeLa, HepG2, MCF-7, SGC-7901 and S... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5294045 Sat, 24 Sep 2011 04:00:00 +0100 5294045 http://www.medworm.com/index.php?rid=5294044&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21968061%26dopt%3DAbstract Authors: Li HF, Guan XY, Yang WZ, Liu KD, Ye M, Sun C, Lu S, Guo DA Abstract Two new flavonoids, wushanicaritin (1) and wushankaempferol (2), along with 24 known flavonoids were isolated from the whole herb of Epimedium wushanense T.S. Ying (Berberidaceae). On the basis of NMR and ESI-MS spectroscopic analysis, structures of compounds 1 and 2 were elucidated as 8-γ-hydroxy-γ,γ-dimethylpropyl-3,5,7-trihydroxy-4'- methoxyflavone and kaempferol 3-O-α-l-[2,3-di-O-β-d-(6-E-p-coumaroyl) glucopyranosyl]-rhamnopyranosyl-7-O-α-l-rhamnopyranoside, respectively. DPPH radical scavenging activity tests indicated that 1 (IC(50) 35.3μM) exhibited antioxidant activity comparable to Vitamin C (IC(50) 32.0μM), while 2 (IC(50) 443.7μM) showed weak activity. PMID: 21968061 [PubMed - as su... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5294044 Sat, 24 Sep 2011 04:00:00 +0100 5294044 http://www.medworm.com/index.php?rid=5294043&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21968062%26dopt%3DAbstract Authors: Chen HY, Ye XL, Cui XL, He K, Jin YN, Chen Z, Li XG Abstract Generally, berberine, coptisine, palmatine, and jatrorrhizine were considered as the main bio-active compounds in Rhizoma Coptis (RC). Little attention was paid to investigate the pharmacological activity of minor constituents in RC. The present study was designed to separate the minor compounds, and the cytotoxicity and antihyperglycemic effect of these compounds in HepG2 cells were also studied. Palmatine (1), berberine (2), coptisine (3), epiberberine (4), columbamine (5), and jatrorrhizine (6) from RC ethanol extract were isolated by high speed counter current chromatography (HSCCC) in one run. The remaining fraction (about 50% of extract in HSCCC) was further isolated by traditional column chromatography met... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5294043 Sat, 24 Sep 2011 04:00:00 +0100 5294043 http://www.medworm.com/index.php?rid=5294042&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21968063%26dopt%3DAbstract Authors: Zheng CJ, Pu J, Zhang H, Han T, Rahman K, Qin LP Abstract Chemical investigation on the seeds of Vitex negundo has afforded a new furan-containing sesquiterpenoid, negunfurol (1), a new norlabdane-type diterpenoid, negundoal (2), and two new norursane-type triterpenoids, negundonorins A (3) and B (4), together with two know compounds, 3-formyl-4,5-dimethyl-8-oxo-5H-6,7-dihydronaphtho[2,3-b]furan (5) and 3-epi-corosolic acid (6). Their structures and configurations were elucidated by detailed spectroscopic analyses on the basis of NMR, IR, and MS data. Compound 3 was strongly cytotoxic against ZR-75-30 cell line with IC(50) value of 0.56±0.19μg/mL, whereas compound 1 was most active against HL-60 cell line with IC(50) value of 0.94±0.26μg/mL. PMID: 21968063 [PubMed ... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5294042 Sat, 24 Sep 2011 04:00:00 +0100 5294042 http://www.medworm.com/index.php?rid=5294040&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21968064%26dopt%3DAbstract Authors: CitoÄŸlu GS, Bahadır O, Yılmaz BS, Ozbek H Abstract The present study reports the potential antinociceptive, anti-inflammatory and hepatoprotective activities of lycorine from Sternbergia fischeriana (Herbert) Rupr. (Amaryllidaceae). Lycorine was evaluated on mice by using acetic-acid induced writhing and tail-flick tests. Lycorine exhibited stronger inhibition than aspirin in acetic-acid induced abdominal stretching at 1.0mg/kg dose. Lycorine also showed antinociceptive activity at 1.0mg/kg dose in tail-flick test. The anti-inflammatory activity of lycorine was not found to be significant at dose of 0.5mg/kg. However, at doses of 1.0mg/kg and 1.5mg/kg, i.p. showed a significant reduction with 53.45% and 36.42%, respectively in rat paw oedema induced by carrageenan again... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5294040 Sat, 24 Sep 2011 04:00:00 +0100 5294040 http://www.medworm.com/index.php?rid=5294038&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21968065%26dopt%3DAbstract Authors: Ochieng' CO, Owuor PO, Mang'uro LA, Akala H, Ishola IO Abstract The chloroform and ethyl acetate extract (100mg/kg) of Caesalpinia volkensii H. exhibited significant (P≤0.05) antinociceptive activities using hot plate and writhing tests in mice while the later showed antiplasmodial activity (IC(50) 0.23±0.07 and 4.39±2.49μg/ml) against chloroquine sensitive (D6) and chloroquine-resistant (W2), respectively. Two new furanoditerpenes [rel. 1β,5α-dihydroxyvoucapane (1) and rel. 1β,6β-dihydroxyvoucapane; 19β-methyl ester (2)] together with seven known compounds [voucapane (3), voucapan-5-ol (4), deoxycaesaldekarin C (5), caesaldekarin C (6), 5-hydroxyvinhaticoic acid (7), triacontanyl-(E)-ferulate (8), triacontanyl-(E)-caffaete (9) and 30'-hydroxytriacontanyl-(E)-fer... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5294038 Sat, 24 Sep 2011 04:00:00 +0100 5294038 http://www.medworm.com/index.php?rid=5272831&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21958965%26dopt%3DAbstract In this study, the apparent partition coefficient and plasma protein binding extent of brucine were determined. In addition, the dose-dependency of the pharmacokinetics of brucine was investigated. Three intravenous (2.5, 5 and 10mg/kg) and three oral (10, 20 and 40mg/kg) doses were administered to rats. After intravenous administration, the systemic clearance was reduced and AUC was nonlinearly increased as a function of dose. Upon oral administration, brucine was rapidly absorbed (T(max)<0.5h), which was consistent with previously reported high Caco-2 P(app) values. The increase in AUC was proportional to the increase in dose. The oral bioavailability (F) did not vary with the dose (F=40.31%, 47.15% and 43.02% for 10, 20, 40mg/kg doses, respectively). However, the dose-proportionality... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5272831 Mon, 19 Sep 2011 04:00:00 +0100 5272831 http://www.medworm.com/index.php?rid=5272830&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21958966%26dopt%3DAbstract Authors: Bony E, Boudard F, Brat P, Dussossoy E, Portet K, Poucheret P, Giaimis J, Michel A Abstract Awara (Astrocaryum vulgare M.) is a palm fruit mainly used in nutrition. We analysed the pulp oil for fatty acid, tocopherol, carotenoid, and phytosterol and we evaluated whether this oil may attenuate inflammation in vivo. In an endotoxic shock model, awara pulp oil treatment decreased pro-inflammatory cytokines and increased anti-inflammatory cytokines. In a pulmonary inflammation model, awara pulp oil treatment reduced eosinophil and lymphocyte numbers recovered into the broncho-alveolar lavages. These results suggest that awara pulp oil administration can efficiently counteract an acute and chronic inflammatory response in vivo that is probably mediated by fatty acids and minor ... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5272830 Mon, 19 Sep 2011 04:00:00 +0100 5272830 http://www.medworm.com/index.php?rid=5272829&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21958967%26dopt%3DAbstract Authors: Wang D, Zhu J, Wang S, Wang X, Ou Y, Wei D, Li X Abstract The primary objective of this study is to evaluate the antitussive, expectorant and anti-inflammatory effects of alkaloids imperialine (I), chuanbeinone (II), verticinone (III), and verticine (IV), which were isolated from the Bulbus Fritillariae Cirrhosae (BFC) using phytochemical method. The results showed that all the alkaloids significantly inhibited cough frequency and increased latent period of cough in mice induced by ammonia. Besides, imperialine(I), verticinone(III) and verticine(IV) markedly enhanced mice's tracheal phenol red output in expectorant evaluation, and imperialine(I), chuanbeinone(II) significantly inhibited the development of ear edema in a dose-dependent manner in anti-inflammatory assessment... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5272829 Mon, 19 Sep 2011 04:00:00 +0100 5272829 http://www.medworm.com/index.php?rid=5272828&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21958968%26dopt%3DAbstract Authors: Li YC, Xian YF, Ip SP, Su ZR, Su JY, He JJ, Xie QF, Lai XP, Lin ZX Abstract Pogostemonis Herba has long been used in traditional Chinese medicine for the treatment of inflammatory disorders. Patchouli alcohol (PA), a tricyclic sesquiterpene isolated from Pogostemonis Herba, is known to possess a variety of pharmacological activities. The present study aimed to investigate the in vivo anti-inflammatory effect of PA using two common inflammatory animal models i.e., xylene-induced ear edema in mice and carrageenan-induced paw edema in rats. The degree of edema in both inflammatory animals, as well as the protein and mRNA expression of some inflammatory mediators including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), prostaglandin E(2) (PGE(2)) and nitric oxide... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5272828 Mon, 19 Sep 2011 04:00:00 +0100 5272828 http://www.medworm.com/index.php?rid=5272827&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21958969%26dopt%3DAbstract Authors: Ptitsyn LR, Nomura K, Sklyar IV, Ravcheeva AB Abstract An aqueous ethanol extract of Pyrola rotundifolia L. induced AMP-activated protein kinase (AMPK) phosphorylation in C2C12 myotubes. The bioassay-guided fractionation of the extract led to the isolation a 2-methyl-7-hydroxymethyl-1,4-naphthoquinone, or a 7'-hydroxy-chimaphilin, which showed concentration-dependent AMPK phosphorylation activity at 2.5-20μg/ml. At a concentration of 10μg/ml (50μM), an approximately four-fold increase in the AMPKα(Thr(172)) phosphorylation level was observed. The stimulatory effect of naphthoquinone on AMPK activity was comparable to that of known compounds found in natural sources that activate the AMPK signaling pathway. PMID: 21958969 [PubMed - as supplied by publisher] (Source:... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5272827 Mon, 19 Sep 2011 04:00:00 +0100 5272827 http://www.medworm.com/index.php?rid=5272833&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21946056%26dopt%3DAbstract Authors: Zhou ZY, Tan JW, Liu JK Abstract Two new polyols, 3-hydroxymethyl-2-methylenepentane-1,4-diol (1) and 1-methylcyclohexane-1,2,4-triol (2), and a new phenylpropanoid glycoside, eugenyl 4″-O-acetyl-β-rutinoside (3), together with seven known steroids (5-11) were isolated from the fruiting bodies of the basidiomycete Lactarius deliciosus. The structures of these compounds were elucidated by the analysis of spectroscopic data. PMID: 21946056 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5272833 Sat, 17 Sep 2011 04:00:00 +0100 5272833 http://www.medworm.com/index.php?rid=5272832&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21946057%26dopt%3DAbstract Authors: Liu X, Qiao L, Xie D, Zhang Y, Zou J, Chen X, Dai J Abstract Biotransformation of ginsenoside-Rg(1) (1) by the fungus Absidia coerulea AS 3.2462 yielded five metabolites (2-6). On the basis of spectroscopic data analyses, the metabolites were identified as ginsenoside-F(1) (2), 6α,12β-dihydroxydammar-3-one-20(S)-O-β-D-glucopyranoside (3), 3-oxo-20(S)-protopanaxatriol (4), 3-oxo-7β-hydroxy-20(S)-protopanaxatriol (5), and 3-oxo-7β,15α-dihydroxy-20(S)-protopanaxatriol (6), respectively. Among them, 5 and 6 are new compounds. These results indicated that Absidia coerulea AS 3.2462 could catalyze the specific C-3 dehydrogenation of derivatives of ginsenoside-Rg(1), as well as hydroxylation at the 7β and 15α positions. Metabolites 2, 4 and 5 exhibited moderate reversal a... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5272832 Sat, 17 Sep 2011 04:00:00 +0100 5272832 http://www.medworm.com/index.php?rid=5215659&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21907267%26dopt%3DAbstract Authors: Maggi F, Barboni L, Caprioli G, Papa F, Ricciutelli M, Sagratini G, Vittori S Abstract Coumarin occurs in many plants used as flavoring and is known to possess hepatotoxic effects. Despite in the EFSA 'Compendium of botanicals containing toxic substances' coumarin is reported to be present in Melittis melissophyllum (bastard balm), a plant traditionally used as beverage in Italy and Serbia, to the best of our knowledge quantitative data has never been reported. Thus, the amount of coumarin in bastard balm leaves and its variation during the annual phenological cycle were determined. The subsp. melissophyllum resulted to contain high levels of coumarin (14,392mg/kg), mainly in the early stages of the plant cycle, suggesting prudence in its use as beverage. Furthermore, coum... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5215659 Wed, 07 Sep 2011 04:00:00 +0100 5215659 http://www.medworm.com/index.php?rid=5215658&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21907268%26dopt%3DAbstract In this study, to clarify which molecular mechanisms and active ingredients of K. parviflora have an anti-obesity effect, we investigated the effect of ethyl acetate extract of K. parviflora (KPE) on TSOD mice, a spontaneously obese Type II diabetes model, and on pancreatic lipase. In the TSOD groups, KPE showed a suppressive effect on body weight increase and visceral fat accumulation and also showed preventive effects on symptoms related to insulin resistance, hypertension and fatty liver. In addition, KPE also suppressed body weight increase and food intake in TSNO mice groups, which served as reference animals, at an early stage of administration. Searching for the ingredients in KPE revealed that KPE contains at least 12 kinds of polymethoxyflavonoid (PMF). Furthermore, KPE and its co... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5215658 Thu, 01 Sep 2011 04:00:00 +0100 5215658 http://www.medworm.com/index.php?rid=5215656&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21907765%26dopt%3DAbstract Authors: Xia YH, Cheng CR, Ji ZN, Yao SY, Zhang Q, Wang Y Abstract AIMS: To investigate the anti-tumor effects of l-securinine inducing colon cancer SW480 cell autophagy and explore its potential molecular mechanism. MAIN METHODS: MTT method was used to detect the antitumor effect of SW480 cells cultured with l-securinine in vitro. Light and electron microscopy were used to observe SW480 cells treated with l-securinine morphological changes. Flow cytometry was used to observe the apoptotic ratio and cell cycle inducing with the l-securinine in SW480 cells, and the autophagic apoptosis ratio was determined by FITC-conjugated annexin V by flow cytometry (FCM). FCM was applied to analysis cell cycle; the expression of autophagy gene Beclin-1 was examined by reverse transcriptase polym... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5215656 Thu, 01 Sep 2011 04:00:00 +0100 5215656 http://www.medworm.com/index.php?rid=5215655&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21907766%26dopt%3DAbstract This study demonstrates how NMR can satisfy the requirement for simultaneous, multi-target quantification and qualitative identification. First, the AS activity was concentrated into a single fraction by RP-solid-phase extraction, as confirmed by an alkaline phosphatase, (anti-)estrogenicity and cytotoxicity assays. Next, a quantitative (1)H NMR (qHNMR) method was established and validated using standard compounds and comparing processing methods. Subsequent 1D/2D NMR and qHNMR analysis led to the identification and quantification of ligustilide and other minor components in the active fraction, and to the development of quality criteria for authentic AS preparations. The absolute and relative quantities of ligustilide, six minor alkyl phthalides, and groups of phenylpropanoids, polyynes, ... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5215655 Thu, 01 Sep 2011 04:00:00 +0100 5215655 http://www.medworm.com/index.php?rid=5215654&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21907767%26dopt%3DAbstract Authors: Fu Q, Huang X, Shu B, Xue M, Zhang P, Wang T, Liu L, Jiang Z, Zhang L Abstract Triptolide, a diterpenoid epoxide, is one of the major active ingredients of Tripterygium wilfordii Hook F, a woody vine plant called lei gong teng in China, which is used in traditional Chinese Medicine (TCM) for treating many diseases. In this paper, we investigate the relation between inhibition of mitochondrial respiratory chain and liver injury induced by triptolide. Results indicate that the secondary β-oxidation impairment caused by inhibition of mitochondrial respiratory chain is involved in triptolide-induced liver injury, which featured by microvesicular steatosis, hyperlactacidemia and enhanced oxidant stress, although other mechanisms of triptolide-induced liver injury may also exis... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5215654 Thu, 01 Sep 2011 04:00:00 +0100 5215654 http://www.medworm.com/index.php?rid=5215653&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21907768%26dopt%3DAbstract This study developed a novel technology, called "after flowing through immobilized receptor (AFTIR)," for targeting components in herbal medicines with α-glucosidase-suppressing capability. As a result, we reveal that the AFTIR system is a highly-efficient drug screening platform, capable of purifying and identifying active components with α-glucosidase-suppressing capability in herbal medicines. PMID: 21907768 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5215653 Thu, 01 Sep 2011 04:00:00 +0100 5215653 http://www.medworm.com/index.php?rid=5215657&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21907269%26dopt%3DAbstract Authors: Nawwar M, Hussein S, Ayoub N, Hashim A, El-Sharawy R, Lindequist U, Harms M, Wende K Abstract Assessment of the UV protecting potential of an aqueous methanol leaf extract of Harpephyllum caffrum proved that it possesses a distinct radical scavenging effect and inhibits the production of the proinflammatory cytokine IL-6 by human keratinocytes (HaCaT cells) following UV radiation. Phytochemical investigation of this extract led to isolation and structural determination of the hitherto unknown phenolics, kaempferol 3-O-(2″-sulphatogalactopyranoside), its quercetin analog and 3-methoxyellagic acid 4-O-galactopyranoside in addition to 18 known phenolic compounds. The structures were determined by spectroscopic and conventional methods of analysis. Flavonoid sulphatoglycosid... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5215657 Wed, 31 Aug 2011 04:00:00 +0100 5215657 http://www.medworm.com/index.php?rid=5215660&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21903153%26dopt%3DAbstract Authors: Salem MM, Davidorf FH, Abdel-Rahman MH Abstract Anti-uveal melanoma activity-guided fractionation of the MeOH extract of Acacia nilotica pods resulted in the isolation of the new compound gallocatechin 5-O-gallate (5) in addition to methyl gallate (1), gallic acid (2), catechin (3), catechin 5-O-gallate (4), 1-O-galloyl-β-D-glucose (6), 1,6-di-O-galloyl-β-D-glucose (7) and digallic acid (8). The structures of the isolated compounds were elucidated on the basis of HRESIMS, NMR spectroscopy and CD data. In addition to uveal melanoma, the antiproliferative activities of the isolated compounds and the related compound epigallocatechin 3-O-gallate (EGCG) were evaluated against cutaneous melanoma, ovarian cancer, glioblastoma and normal retinal pigmented cells. PMID: 21903... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5215660 Sun, 28 Aug 2011 04:00:00 +0100 5215660 http://www.medworm.com/index.php?rid=5215662&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21893171%26dopt%3DAbstract Authors: Inchoo M, Chirdchupunseree H, Pramyothin P, Jianmongkol S Abstract The purpose of this study was to investigate the modulating effects of phyllanthin and hypophyllanthin on vascular tension, using in the in vitro model of isolated rat aorta. Our results indicated that both phyllanthin and hypophyllanthin significantly relaxed the sustained contraction induced by phenylephrine (PE) in a concentration-dependent manner. In addition, endothelial removal had no significant influence on the vasorelaxation responses of the aortic rings toward these two compounds. Furthermore, both compounds inhibited the contraction of aortic muscle provoked by either PE (1μM) or KCl (40mM) as well as the spontaneous contraction of the Ca(2+)-depleted muscle. In high K(+)- Ca(2+) free solution, ... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5215662 Sat, 27 Aug 2011 04:00:00 +0100 5215662 http://www.medworm.com/index.php?rid=5215661&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21893172%26dopt%3DAbstract Authors: Ribeiro PR, Ferraz CG, Guedes ML, Martins D, Cruz FG Abstract Phytochemical investigation on Clusia burlemarxii (Clusiaceae) led to isolation and identification of nine compounds. Were isolated from leaves 3-O-α-L- rhamnopyranosylquercetin, 3-O-α-L-rhamnopyranosylkaempferol, 4-hydroxy-5,5-dimethyldihydrofuran-2-one, 2Z-δ-tocotrienoloic acid and friedelin and were isolated from trunk betulinic acid, protocatechuic acid, lyoniresinol, and a new biphenyl 2,2-dimethyl-3,5-dihydroxy-7-(4-hydroxyphenyl)chromane. The structures were determined by (1)H, (13)C-NMR, DEPT, HMBC, HMQC, HRESIMS. The Minimal Inhibitory Concentration against Streptococcus mutans, Staphylococcus aureus, Bacillus subtilis, Micrococcus luteus, Escherichia coli, Salmonella choleraesuis, Pseudomonas aerugi... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5215661 Sat, 27 Aug 2011 04:00:00 +0100 5215661 http://www.medworm.com/index.php?rid=5215665&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21888953%26dopt%3DAbstract Authors: Singh SP, Wahajuddin , Tewari D, Patel K, Jain GK Abstract In the present study, we are reporting permeability and pharmacokinetics of nobiletin in rat plasma and brain, using a validated reverse phase high performance liquid chromatographic method. Protein precipitation method was used for the extraction of nobiletin and coumarin (IS) from rat plasma and brain tissue. The system was run in isocratic mode with mobile phase consisting of potassium dihydrogen ortho-phosphate (pH 4.5; 0.04mM) and acetonitrile in ratio of 50:50, v/v. The total chromatographic run time was 9.0min. The method was proved to be accurate and precise at linearity range of 0.05-10μg/mL with a correlation coefficient (r) of ≥0.994 in rat plasma and ≥0.995 in rat brain. The intra- and inter-day pr... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5215665 Tue, 23 Aug 2011 04:00:00 +0100 5215665 http://www.medworm.com/index.php?rid=5215664&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21888954%26dopt%3DAbstract Authors: Zhou W, Di LQ, Shan JJ, Bi XL, Chen LT, Wang LC, Cai BC Abstract Shuang-Huang-Lian (SHL), a traditional Chinese formula containing Lonicerae japonicae flos (LJF), Scutellariae radix (SR) and Forsythiae fructus (FF), is commonly used to treat acute upper respiratory tract infection, acute bronchitis and light pneumonia. Forsythoside A is one of the main active ingredients in Forsythiae fructus, a key herb in SHL. In the present study, effects of different compositions in SHL on the in vitro metabolism in Sprague-Dawley rat liver microsomes of forsythoside A were investigated. The observations from Sprague-Dawley rat liver microsomes in the presence of β-NADPH or UDPGA that forsythoside A may be the substrates of CYP3A4, CYP2C9, CYP1A2, UGT1A6, UGT1A3, UGT1A1 and UGT1A9; Ch... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5215664 Tue, 23 Aug 2011 04:00:00 +0100 5215664 http://www.medworm.com/index.php?rid=5215663&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21888955%26dopt%3DAbstract Authors: Wu DC, Li S, Yang DQ, Cui YY Abstract Pinus massoniana Lamb is a Chinese red pine species used in traditional medicine for the treatment of a variety of human health disorders. Recent studies have shown that P. massoniana bark extract (PMBE) has an anti-proliferation effect on cancer cells. However, it is not clear if PMBE affects cancer cell migration and/or invasion. We tested the effect of PMBE, which has B-type procyanidin as its main constituent, on the adhesion and migration capabilities of HeLa cells, a human cervical cancer cell line, cultured in vitro. Our results showed that PMBE has no significant effect on the adhesion capability of HeLa cells, but strongly inhibits their migration. This finding suggests that PMBE could be a potential therapeutic agent for meta... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5215663 Tue, 23 Aug 2011 04:00:00 +0100 5215663 http://www.medworm.com/index.php?rid=5171225&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21867747%26dopt%3DAbstract Authors: Wang B, Deng J, Gao Y, Zhu L, He R, Xu Y Abstract Hunting lead compounds from natural products plays a vital role in finding successful drug candidates. The efficiency of screening campaigns is mainly determined by the validity of selected screening models. To screen desired lead compounds, researchers have developed a plethora of experimental screening models. However, the considerable diversity of screening models from animal models, tissue models, to cell models and so on, may cause some trouble in choosing the suitable one. This review provides a toolbox of experimental screening models that have been used to discover new drug candidates from natural products. Two screening indexes are designed for different research directions in this screening toolbox. Index I is pro... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5171225 Thu, 11 Aug 2011 23:00:00 +0100 5171225 http://www.medworm.com/index.php?rid=5147399&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21856384%26dopt%3DAbstract Authors: Wang F, Guan Y Abstract Four new nor-dammarane triterpenoids, 12β-O-acetyl-15α,28-dihydoxy-17β-methoxy-3-oxo-20,21,22-23,24,25,26,27-octanordammanran (1), 12β-O-acetyl-15α,17β,28-trihydoxy-3-oxo-20,21,22-23,24,25,26,27-octanordammanran (2), 12β-O-acetyl-15α,28-dihydoxy-3-oxo-17-en-20,21,22-23,24,25,26,27-octanordammanran (3), and 12β,15α,17β,28-tetrahydoxy-3-oxo-20,21,22-23,24,25,26,27-octanordammanran (4), were isolated from the 70% EtOH extract of Dysoxylum hainanense. The structures of the new compounds were elucidated by spectral methods. All the triterpenoids were in vitro evaluated for their cytotoxic activities against four tumor cell lines (A549, SK-OV-3, SKMEL-2 and HCT15). PMID: 21856384 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5147399 Thu, 11 Aug 2011 23:00:00 +0100 5147399 http://www.medworm.com/index.php?rid=5147398&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21856385%26dopt%3DAbstract Authors: Xu J, Guo Y, Zhao P, Xie C, Jin DQ, Hou W, Zhang T Abstract Three new cadinane sesquiterpenes, commiterpenes A-C (1-3), were isolated from the resinous exudates of Commiphora myrrha. Their structures and relative configurations were elucidated by spectroscopic methods (IR, ESIMS, HRESIMS, 1D and 2D NMR). All the isolated sesquiterpenes showed neuroprotective effects against MPP(+)-induced neuronal cell death in SH-SY5Y cells. PMID: 21856385 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5147398 Wed, 10 Aug 2011 23:00:00 +0100 5147398 http://www.medworm.com/index.php?rid=5147397&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21856386%26dopt%3DAbstract Authors: Adão CR, da Silva BP, Parente JP Abstract A new steroidal saponin was isolated from the bulbs of Allium ampeloprasum var. porrum L. On the basis of chemical evidence, comprehensive spectroscopic analyses and comparison of known compounds, its structure was established as (3β,5α,6β,25R)-6-[(β-d-glucopyranosyl)oxy]-spirostan-3-yl O-β-d-glucopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→3)]-β-d-galactopyranoside (1). Results of the present study indicated that the steroidal saponin showed haemolytic effects in the in vitro assays and demonstrated antiinflammatory activity and gastroprotective property using in vivo models. PMID: 21856386 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5147397 Wed, 10 Aug 2011 23:00:00 +0100 5147397 http://www.medworm.com/index.php?rid=5147396&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21856387%26dopt%3DAbstract Authors: Udomsuk L, Juengwatanatrakul T, Putalun W, Jarukamjorn K Abstract Miroestrol and deoxymiroestrol are phytoestrogens isolated from tuberous root of Pueraria candollei var. mirifica. Modulatory effects of miroestrol and deoxymiroestrol on enzymes involved in sex-hormone synthesis pathway in male C57BL/6 mice were investigated using semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR). Miroestrol and deoxymiroestrol suppressed the expressions of 3β-HSD, 17β-HSD1, and CYP17 while CYP19 mRNA expression was slightly decreased. In addition, the expression of 17β-HSD2 was induced in correlation with those did by estradiol. These observations supported that miroestrol and deoxymiroestrol could exhibit the same effect as estradiol regarding regulation of tes... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5147396 Wed, 10 Aug 2011 23:00:00 +0100 5147396 http://www.medworm.com/index.php?rid=5147395&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21856388%26dopt%3DAbstract Authors: Liu J, Shu J, Zhang R, Zhang W Abstract Two new C(14) pterosin dimers, which are a pair of isomers named as bimutipterosins A (1) and B (2), were isolated from the whole plant of Pteris multifida. Their structures have been elucidated on the basis of NMR and MS data. From a biogenetic point of view, these compounds including a cyclobutane basic core should be considered as a [2+2] dimerization product of dehydropterosin Q, which was a known compound and also isolated from this plant. This novel type of pterosin dimer was reported here for the first time. Compounds 1 and 2 showed cytotoxicity against HL 60 cell line (human leukemia) with the IC(50) values of 12.8 and 26.6μM, respectively. PMID: 21856388 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5147395 Wed, 10 Aug 2011 23:00:00 +0100 5147395 http://www.medworm.com/index.php?rid=5138761&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21835229%26dopt%3DAbstract Authors: Songsiang U, Hahnvajanawong C, Yenjai C Three new compounds, dalberpene (1), dalparvinene B (2) and dalparvone B (3), as well as 12 known compounds were isolated from the heartwood of Dalbergia parviflora. Isoflavanone 13 showed strong cytotoxicity against KB, MCF-7 and NCI-H187 cell lines with IC(50) values ranging from 3.5 to 5.4μg/mL and it was inactive against normal cells. PMID: 21835229 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5138761 Fri, 29 Jul 2011 23:00:00 +0100 5138761 http://www.medworm.com/index.php?rid=5138749&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21835230%26dopt%3DAbstract Authors: Zhang A, Sun H, Yuan Y, Sun W, Jiao G, Wang X 6,7-Dimethylesculetin (D), geniposide (G) and rhein (R) are the three major active ingredients of Yin-Chen-Hao-Tang (YCHT), a famous Chinese herbal formula, which has been shown to be clinically effective for treating hepatic injury (HI) syndrome. The present study was conducted to investigate the therapeutic and synergistic effects of COC (combination of D, G and R) on HI rats by combining pharmacokinetic with biochemical analysis strategy. Plasma was analyzed by using reversed-phase high performance liquid chromatography (RP-HPLC). Principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) models were built to evaluate the therapeutic and synergistic effects of COC at the biochemical level. Here, ... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5138749 Thu, 28 Jul 2011 23:00:00 +0100 5138749 http://www.medworm.com/index.php?rid=5138808&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21820038%26dopt%3DAbstract Authors: Rocher MN, Carré D, Spinnewyn B, Schulz J, Delaflotte S, Pignol B, Chabrier PE, Auguet M The standardized extract of Ginkgo biloba EGb 761 has been used to reduce cognitive dysfunction. The present study was designed to evaluate the effect of postischemic oral treatment with EGb 761 in a model of vascular dementia in gerbils. Daily oral posttreatment with EGb 761 led to a significant recovery of spatial memory assessed by the object location test, inhibited the decrease in plasma SOD activity and protected the hippocampal CA1 neurons, even when administered after the insult. These data provide further evidence for the therapeutic potential of EGb 761 in the treatment of vascular dementia. PMID: 21820038 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5138808 Tue, 26 Jul 2011 23:00:00 +0100 5138808 http://www.medworm.com/index.php?rid=5138791&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21820495%26dopt%3DAbstract Authors: Lin B, Wang G, Wang Q, Ge C, Qin M A novel dimeric 1,4-benzoquinone and resorcinol derivative, Belamcandaquinone N (1), and two known compounds, 3-hydroxyirisquinone (2) and 5-[(Z)-10-heptadecenyl] resorcinol (3), were isolated from the seeds of Iris bungei Maxim. Their structures were elucidated by spectroscopic methods and comparing with literature data of known compounds. These compounds showed remarkable cytotoxic activity against RM-1 cell lines. PMID: 21820495 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5138791 Tue, 26 Jul 2011 23:00:00 +0100 5138791 http://www.medworm.com/index.php?rid=5138821&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21816210%26dopt%3DAbstract This study compared the pharmacokinetics of dehydroevodiamine and coptisine, the main active ingredients in Zuojinwan, in rats administrated with whole prescription or single herbs. Multiple blood concentration peaks were observed in the mean plasma-concentration curves. The pharmacokinetic parameters were quite different between single herbs and Zuojinwan prescription. Moreover, the mean plasma concentration of dehydroevodiamine increased and the one of coptisine decreased after combining, which was in accord with the clinical principle of TCM. PMID: 21816210 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5138821 Fri, 22 Jul 2011 23:00:00 +0100 5138821 http://www.medworm.com/index.php?rid=5088955&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21803129%26dopt%3DAbstract Authors: Sidana J, Singh S, Arora SK, Foley WJ, Singh IP Two new naturally occurring formylated phloroglucinol compounds (FPCs), a dimer, loxophlebal B (10) and a cyclized FPC, loxophlebene (8) together with eight other formylated phloroglucinols (1-7 and 9) were isolated from the chloroform-methanol (8:2) extract of the leaves of Eucalyptus loxophleba ssp. lissophloia. The structures of new compounds were established by comprehensive spectral analysis and by comparison of their NMR data with those of related compounds in the literature. All the isolated compounds were evaluated for anti-leishmanial activity against promastigotes of Leishmania donovani. PMID: 21803129 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5088955 Fri, 22 Jul 2011 23:00:00 +0100 5088955 http://www.medworm.com/index.php?rid=5088954&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21807074%26dopt%3DAbstract Authors: Cheng LL, Chen XN, Wang Y, Yu L, Kuang X, Wang LL, Yang W, Du JR We investigated the effect of Z-ligustilide (LIG) on scopolamine-induced memory impairment in ICR mice. LIG (2.5-40mg/kg) or tacrine (10mg/kg) was orally administrated for 26days. Behavior was examined in the Morris water maze and Y-maze after scopolamine administration (2mg/kg, i.p.). The central acetylcholinesterase (AChE) and choline acetyltransferase (ChAT) activity was assessed spectrophotometrically. LIG significantly improved spatial long-term memory and short-term memory impairment, inhibited AChE activity and increased ChAT activity. Moreover, LIG and tacrine showed the comparable efficacy in both neurobehavioral and cholinergic evaluation. These data suggest that LIG may alleviate memory deficits probab... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5088954 Fri, 22 Jul 2011 23:00:00 +0100 5088954 http://www.medworm.com/index.php?rid=5088953&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21807075%26dopt%3DAbstract Authors: Guo P, Li Y, Xu J, Guo Y, Jin DQ, Gao J, Hou W, Zhang T Three new (1-3) and three known (4-6) neo-clerodane diterpenes have been isolated from the whole plants of Ajuga ciliata Bunge. The structures of the new compounds were elucidated as (12S)-1β, 6α,19-triacetoxy-18-chloro-4α,12-dihydroxy-neo-clerod-13-en-15,16-olide (1), (12S,2'S)-12,19-diacetoxy-18-chloro-4α,6α-dihydroxy-1β-(2-methylbutanoyloxy)-neo-clerod-13-en-15,16-olide (2), and (12S)-6α,18,19-triacetoxy-4α,12-dihydroxy-1β-tigloyloxy-neo-clerod-13-en-15,16-olide (3), on the basis of spectroscopic data analysis. All the diterpenes were evaluated for the neuroprotective effects against MPP(+)-induced neuronal cell death in dopaminergic neuroblastoma SH-SY5Y cells and compounds 2-5 exhibited moderate neuroprotect... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5088953 Fri, 22 Jul 2011 23:00:00 +0100 5088953 http://www.medworm.com/index.php?rid=5088952&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21807076%26dopt%3DAbstract Authors: Xu J, Zhao P, Guo Y, Xie C, Jin DQ, Ma Y, Hou W, Zhang T Three new iridoids, valeriandoids A-C (1-3), together with three known analogues (4-6), were isolated from the roots of Valeriana jatamansi. Their structures and relative configurations were elucidated by spectroscopic methods (IR, ESIMS, HRESIMS, 1D and 2D NMR) and by comparison of their NMR data with those of related compounds. All isolated compounds were evaluated for their neuroprotective effects and compounds 1, 3, 4 and 6 showed moderate neuroprotective effects. PMID: 21807076 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5088952 Fri, 22 Jul 2011 23:00:00 +0100 5088952 http://www.medworm.com/index.php?rid=5088957&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21787850%26dopt%3DAbstract Authors: Xie H, Yan MC, Jin D, Liu JJ, Yu M, Dong D, Cai CC, Pan SL Piper laetispicum C.DC. (Piperaceae), is an endemic climbing, glabrous plant distributed in the southern part of China. A novel alkaloid amide, Laetispicine, from it has been proven to possess antidepressant activity. In this present study, antidepressant and antinociceptive effects of the ethyl acetate extract (EAE) of P. laetispicum have been studied in forced swimming, open field, acetic acid writhing and formalin tests in KM mice. A significantly antidepressant-like effect was showing at doses of higher than 60mg/kg, which was not due to an increase in locomotive activity. The EAE also presented an analgesic effect, in our studies. At lower doses (30mg/kg) the antinociceptive effect was likely mediated via peripher... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5088957 Thu, 21 Jul 2011 23:00:00 +0100 5088957 http://www.medworm.com/index.php?rid=5088956&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21798321%26dopt%3DAbstract Authors: Eisenman SW, Poulev A, Struwe L, Raskin I, Ribnicky DM Ethanolic extracts of diploid Artemisia dracunculus L. (wild tarragon) from populations in the U.S., and polyploid tarragon from a variety of sources, were screened for the anti-diabetic compounds davidigenin; sakuranetin; 2',4'-dihydroxy-4-methoxydihydrochalcone; 4,5-di-O-caffeoylquinic acid; 5-O-caffeoylquinic acid and 6-demethoxycapillarisin using LC-MS. Only decaploid plants contained all six target compounds and were the only plants that contained davidigenin and 2,4-dihydroxy-4-methoxydihydrochalcone. These results exhibit the importance of germplasm selection and provenance when studying plants for medicinal activity. Relying only on the "right species" for consistent medicinal activities may not be sufficient, as i... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5088956 Wed, 20 Jul 2011 23:00:00 +0100 5088956 http://www.medworm.com/index.php?rid=5088961&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21787846%26dopt%3DAbstract Authors: Sun ZL, Zhang M, Wu Y, Wan AH, Zhang R Continued chemical investigation on the fruits of Aesculus pavia L. resulted in theisolation and identification of two new oleanolic acid saponins, namely vaccaroside A (1) andvaccaroside B (2). The isolated furostanol saponins were evaluated for cytotoxic activity againsthuman normal amniotic and human lung carcinoma cell lines using neutral red and MTT assays.In vitro experiments showed significant cytotoxicity in a dose dependent manner with IC50 valuesin the range of 27.80-79.02 μM. PMID: 21787846 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5088961 Tue, 19 Jul 2011 23:00:00 +0100 5088961 http://www.medworm.com/index.php?rid=5088960&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21787847%26dopt%3DAbstract Authors: Zhao ZX, Jin J, Lin CZ, Zhu CC, Liu YM, Lin AH, Liu YX, Zhang L, Luo HF Two new chalcone glycosides 4'-O-(6″-O-galloyl-β-d-glucopyranosyl)-2',4-dihydroxychalcone (1) and 4'-O-(6″-O-galloyl-β-d-glucopyranosyl)-2'-hydroxy-4-methoxychalcone (2) together with one known chalcone glycoside 4'-O-β-d-glucopyranosyl-2'-hydroxy-4-methoxychalcone (3) were isolated from the stems of Entada phaseoloides. The structures of the new compounds were elucidated on the basis of extensive spectroscopic analysis, including HSQC, HMBC, (1)H-(1)H COSY, and chemical evidences. This is the first report of chalcone-type compounds isolated from the genus Entada. PMID: 21787847 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5088960 Tue, 19 Jul 2011 23:00:00 +0100 5088960 http://www.medworm.com/index.php?rid=5088959&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21787848%26dopt%3DAbstract Authors: Geng T, Sun Y, Yao W, Ding A, Zhang L, Guo J, Tang Y Schizonepetin, a natural monoterpene from Herba Schizonepetae, is a potential antiviral agent. In this paper, a simple, rapid and sensitive HPLC-UV method was first developed and validated for the determination of schizonepetin in rat plasma and tissue homogenates after oral and intravenous administration. The results showed that schizonepetin was absorbed and eliminated rapidly, and its oral absolute bioavailability in rats achieved about 75%. The drug distributed widely in various tissues of rats, and had no long-term accumulation in vivo. The research provides reliable scientific data for designing drug treatment regimens of schizonepetin. PMID: 21787848 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5088959 Tue, 19 Jul 2011 23:00:00 +0100 5088959 http://www.medworm.com/index.php?rid=5088958&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21787849%26dopt%3DAbstract Authors: Siriwan D, Naruse T, Tamura H The present study investigated the cytotoxicity of enhydrin (1), uvedalin (2) and sonchifolin (3) in cervical cancer cells. We have found that SLs 1-3 in doses in range of 0.22-10μM inhibited cell proliferation and induced apoptosis in both a dose- and time-dependent fashion. A significant cell death induction was supported by morphological studies. The apoptotic effect is associated with caspase-3/7 activation and NF-кB inhibition. Interestingly, enhydrin possessing two epoxide units was found to be the most cytotoxic compound. Therefore it can be assumed that number of epoxides and existence of α-methylene-γ-lactone moiety are essential for the acceleration of apoptosis. PMID: 21787849 [PubMed - as supplied by publisher] (Source: Fitoter... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5088958 Tue, 19 Jul 2011 23:00:00 +0100 5088958 http://www.medworm.com/index.php?rid=5088962&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21784137%26dopt%3DAbstract Authors: Li S, Li J, Guan XL, Li J, Deng SP, Li LQ, Tang MT, Huang JG, Chen ZZ, Yang RY The various fractions of the barks of Cyclocarya paliurus were systematically tested for hypoglycemic effects in alloxan-induced diabetic rats. The results showed that the chloroform fraction of the 75% EtOH extract of the barks of this plant exhibited significant blood sugar reducing activity, most of which were significantly higher than that of positive-drug metformin hydrochloride. A new compound, together with nine known compounds, was isolated from the most active fraction. The structure elucidation was based on spectroscopic methods, including two-dimensional NMR experiments (((1))H-((1))H COSY, HMQC, and HMBC). All of the isolates were evaluated for their α-glycosidase and glycogen phosphory... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5088962 Mon, 18 Jul 2011 23:00:00 +0100 5088962 http://www.medworm.com/index.php?rid=5088963&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21767617%26dopt%3DAbstract Authors: Fu SB, Yang JS, Cui JL, Meng QF, Feng X, Sun DA The structural modification of ursolic acid by an endophytic fungus Pestalotiopsis microspora, isolated from medicinal plant Huperzia serrata was reported for the first time. The structure diversity was very important for the SAR study of ursolic acid and its derivatives. Incubation of ursolic acid 1 with P. microspora afforded four metabolites: 3-oxo-15α, 30-dihydroxy-urs-12-en-28-oic acid (2), 3β, 15α-dihydroxy-urs-12-en-28-oic acid (3), 3β, 15α, 30- trihydroxy-urs-12-en-28-oic acid (4) and 3,4-seco-ursan-4,30-dihydroxy-12-en-3,28-dioic acid (5). All products were new compounds and their structures elucidation was mainly based on the spectroscopic data. PMID: 21767617 [PubMed - as supplied by publisher] (Source: Fitote... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5088963 Fri, 01 Jul 2011 23:00:00 +0100 5088963 http://www.medworm.com/index.php?rid=5038840&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21745549%26dopt%3DAbstract Authors: Reddy KD, Rao BV, Babu GS, Kumar BR, Braca A, Vassallo A, De Tommasi N, Rao GV, Rao AV Phytochemical investigation of Caralluma adscendens var. gracilis and Caralluma pauciflora (Asclepiadaceae) whole plant extracts allowed to isolate one pregnane glycoside and two pregnanes characterized as 12β,20-O-dibenzoyl-5α,6-dihydrosarcostin β-oleandropyranosyl-(1→4)-β-cymaropyranosyl-(1→4)-β-digitoxypyranosyl-(1→4)-β-cymaropyranosyl-(1→4)-β-cymaropyranoside (1), 12β-O-benzoyl-3β,11α,14β,20R-pentahydroxy-pregn-5-ene (2), and 11α-O-benzoyl-3β,12β,14β,20R-pentahydroxy-pregn-5-ene (3), respectively. Their structural characterization was obtained on the basis of extensive NMR spectral studies. Three known pregnane glycosides along with lupeol and β-sitosterol were al... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5038840 Fri, 01 Jul 2011 23:00:00 +0100 5038840 http://www.medworm.com/index.php?rid=5038839&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21745550%26dopt%3DAbstract Authors: Ganjare AB, Nirmal SA, Patil AN Cordia dichotoma f. (Boraginaceae) is a small deciduous tree from India. The bark of was used in the treatment of ulcerative colitis (UC) and colic pain traditionally hence present work was undertaken to identify the phytoconstituent responsible for this activity. Apigenin is isolated by column chromatography from methanol fraction of crude methanol extract of C. dichotoma bark. Structure of apigenin is established by various spectroscopic studies. Apigenin (5mg/kg, p.o.) showed significant healing and reduction in inflammatory enzymes when screened for UC. It can be concluded that apigenin from C. dichotoma bark may be responsible for the treatment of UC. PMID: 21745550 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5038839 Fri, 01 Jul 2011 23:00:00 +0100 5038839 http://www.medworm.com/index.php?rid=5038838&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21745551%26dopt%3DAbstract Authors: Somwong P, Suttisri R, Buakeaw A A new 1,3-diketofriedelane triterpene, 21α-hydroxyfriedelane-1,3-dione (1) together with six known friedelane triterpenes, 30-hydroxyfriedelane-1,3-dione (2), friedelane-1,3-dione (3), 26-hydroxyfriedelane-1,3-dione (4), friedelin (5), 21α-hydroxy-D:A-friedo-olean-3-one (6) and kokoonol (7), were isolated from the stems of Salacia verrucosa (Celastraceae). The structures of these triterpenes were characterized by spectroscopic methods (IR, MS and NMR). Compound 3 was strongly cytotoxic against SW620 cell line, whereas compounds 4 and 6 were moderately active against SW620, HepG2 and KATO-III cancer cell lines. PMID: 21745551 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5038838 Fri, 01 Jul 2011 23:00:00 +0100 5038838 http://www.medworm.com/index.php?rid=5038837&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21745552%26dopt%3DAbstract Authors: Zheng CJ, Sun PX, Jin GL, Qin LP Two new sesquiterpenoids, identified as (rel 1S, 3R, 4R, 7R)-3-[5-hydroxy-4-methylpent-3-enyl]-1, 3, 7-trimethyl-2-oxabicyclo [2, 2, 1] heptane (1) and (rel 1S, 3R, 4R, 7R)-3-[3, 4-dihydroxy-4-methylpentyl]-1, 3, 7-trimethyl-2-oxabicyclo [2, 2, 1] heptane (2), were isolated from cultures of Trichoderma atroviride (strain no. S361), an endophytic fungal strain residing in the bark of Cephalotaxus fortunei. The structures of compounds 1 and 2 were elucidated by detailed spectroscopic analyses on the basis of NMR, IR, and MS data. Both compounds 1 and 2 were potent inhibitors on NO production in LPS-stimulated RAW264.7 cells, with IC(50) values of 15.3 and 9.1μM, respectively. PMID: 21745552 [PubMed - as supplied by publisher] (Source: Fitote... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5038837 Fri, 01 Jul 2011 23:00:00 +0100 5038837 http://www.medworm.com/index.php?rid=5038836&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21749916%26dopt%3DAbstract Authors: Deng Z, Zhong H, Cui S, Wang F, Xie Y, Yao Q A new sesquiterpenoid, namely Linerenone (1), together with three known sesquiterpenoids (2-4), were isolated from the fruits of Lindera communis. Their structures were determined by extensive spectroscopic analysis including 1D, 2D-NMR and HR-MS spectra. Compound 1 showed significant cytotoxic activity against H460, ES2 and DU145 cancer cells with IC(50) of 2.1μg/mL, 2.8μg/mL and 3.0μg/mL, respectively. PMID: 21749916 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5038836 Fri, 01 Jul 2011 23:00:00 +0100 5038836 http://www.medworm.com/index.php?rid=5038841&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21741458%26dopt%3DAbstract Authors: Bie X, Chen Y, Zheng X, Dai H The protective role of crocetin following cerebral contusion and its effects on the enhancement of angiogenesis in rats was investigated. A total of 60 Sprague-Dawley rats were divided into three groups (n=20 each): crocetin therapy group (cerebral contusion treated with crocetin), cerebral trauma control group (without treatment), sham operation control group. The effect of crocetin was examined by modified Neurological Severity Scores (mNSS), electron microscopy, terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling (TUNEL) procedure, western blotting analysis of Bcl-2 protein expression, microvessel count (MVC), endothelial cell culture and immunocyto-chemistry. The mNSS results indicated that neurological function of therapy grou... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5038841 Wed, 29 Jun 2011 23:00:00 +0100 5038841 http://www.medworm.com/index.php?rid=5038842&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21723379%26dopt%3DAbstract Authors: César GZ, Alfonso MG, Marius MM, Elizabeth EM, Angel CB, Maira HR, Guadalupe CL, Manuel JE, Ricardo RC Calophyllum species are sources of calanolides, which inhibit human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT). The hexane extract of the leaves from C. brasiliense collected in Soconusco, State of Chiapas, Mexico, analyzed by HPLC showed to contain apetalic acid, calanolides B, and C. It showed potent anti-HIV-1 RT inhibition (IC(50)=20.2μg/ml), but was not toxic in mice (LD(50)=1.99g/kg). The histological study of the mice treated at the highest dose revealed no alteration on hepatocytes, and an increase in the number of spleen megakaryocytes. These results suggest this extract is suitable to continue studies for developing a phytodrug against HIV-1. ... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=5038842 Thu, 23 Jun 2011 23:00:00 +0100 5038842 http://www.medworm.com/index.php?rid=4994822&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21708227%26dopt%3DAbstract This study demonstrates the applicability of the HPLC/off-line microprobe NMR approach as a robust means for rapid phytochemical profiling of plant extracts. PMID: 21708227 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=4994822 Thu, 23 Jun 2011 23:00:00 +0100 4994822 http://www.medworm.com/index.php?rid=4994821&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21708228%26dopt%3DAbstract Authors: Shreaz S, Bhatia R, Khan N, Manzoor N, Muralidhar S, Khan LA Fluconazole resistance is becoming an important clinical concern. We studied the in vitro effects of cinnamaldehyde against 18 fluconazole-resistant Candida isolates. MIC(90) of cinnamaldehyde against different Candida isolates ranged 100-500μg/ml. Growth and sensitivity of the organisms were significantly affected by cinnamaldehyde at different concentrations. The rapid irreversible action of this compound on fungal cells suggested membrane-located targets for its action. Insight studies to mechanism suggested that cinnamaldehyde exerts its antifungal activity by targeting sterol biosynthesis and plasma membrane ATPase activity. Inhibition of H(+)-ATPase leads to intracellular acidification and cell death. Toxicity... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=4994821 Thu, 23 Jun 2011 23:00:00 +0100 4994821 http://www.medworm.com/index.php?rid=4994824&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21699963%26dopt%3DAbstract Authors: Khan I, Nisar M, Shah MR, Shah H, Gilani SN, Gul F, Abdullah SM, Ismail M, Khan N, Kaleem WA, Qayum M, Khan H, Obaidullah , Samiullah , Ullah M Current study was conducted to identify constituents of Taxus wallichiana Zucc. that might be responsible for its folk use in anti-inflammatory conditions. Taxusabietane A was isolated from the bark extract of Taxus wallichiana Zucc. Taxusabietane A was analyzed for in-vitro and in-vivo anti-inflammatory activities using Lipoxygenase (LOX) inhibition assay and carrageenan-induced paw edema model. Taxusabietane A revealed considerable LOX inhibitory activity with the IC(50) value being 57±0.31. Standard compound Baicalein showed the IC(50) value being 22.1±0.03μM. Taxusabietane A also showed significant (5 and 10mg/kg) anti-inflammat... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=4994824 Tue, 14 Jun 2011 23:00:00 +0100 4994824 http://www.medworm.com/index.php?rid=4994823&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21703333%26dopt%3DAbstract Authors: Nisar M, Kaleem WA, Khan I, Adhikari A, Khan N, Shah MR, Khan IA, Qayum M, Samiullah , Ismail M, Aman A Zizyphus oxyphylla Edgew is used in Pakistan as a folk medicinal remedy for inflammatory conditions, pains especially rheumatic pain, fevers, allergy and diabetes. The aim of the current study was to scientifically validate the folk use of Z. oxyphylla Edgew by using the isolated compound in vitro and in vivo levels. Kushecarpin A was isolated from ethyl acetate fraction of the plant crude extract. Kushecarpin A showed significant lipoxygenase inhibition (IC(50): 7.2±0.02μM). It also exhibited significant and highly significant inhibition (p<0.05 and p<0.01) of carrageenan-induced hind paw oedema at the doses of 5, 10 and 20mg/kg. Kushecarpin A seems to be a potentia... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=4994823 Tue, 14 Jun 2011 23:00:00 +0100 4994823 http://www.medworm.com/index.php?rid=4945908&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21679750%26dopt%3DAbstract Authors: Zhang Y, Cao Y, Wang Q, Zheng L, Zhang J, He L Imperatorin (Imp) as a hypotensive active ingredient, its hypotensive effect was evaluated in the SHRs, its calcium antagonism and affinity to L-type calcium channel was also confirmed. The results showed that the blood pressure was decreased in the SHRs, the aortic ring was relaxed, L-type calcium channel currents and intracellular calcium free ion rise was nearly disappeared treated with Imp. In addition, Imp displayed a chromatographic peak similar to nitrendipine and verapamil by the cell membrane chromatography, same results from protein-drug docking approaches. Hence, Imp target the L-type calcium channel, and may be used as a novel antihypertensive drug. PMID: 21679750 [PubMed - as supplied by publisher] (Source: Fitote... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=4945908 Sun, 05 Jun 2011 23:00:00 +0100 4945908 http://www.medworm.com/index.php?rid=4945912&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21641970%26dopt%3DAbstract Authors: Feng AW, Yu C, Mao Q, Li N, Li QR, Li JS The effect of berberine hydrochloride (BBR) on inducible cyclooxygenase-2 (COX-2) in small intestinal mucosa and related mechanisms was investigated in a rat model of acute endotoxemia. The results showed that lipopolysaccharide (LPS) increased COX-2 expression, whereas SB202190 and BBR curtailed it. LPS increased phosphorylation of mucosal p38 MAPK and ATF2 as well as production of ATF2, whereas BBR attenuated these effects. LPS upregulated mucosal peroxisome proliferator-activated receptor gamma (PPARγ), but BBR reduced this receptor. GW9662 aggravated LPS-induced and reversed BBR-attenuated COX-2 expression. The findings showed that BBR ameliorated COX-2 overexpression partially via modulation of p38 and PPARγ pathways during acute... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=4945912 Thu, 26 May 2011 23:00:00 +0100 4945912 http://www.medworm.com/index.php?rid=4945911&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21641971%26dopt%3DAbstract Authors: Cota BB, de Oliveira DM, de Siqueira EP, Souza-Fagundes EM, Pimenta AM, Santos DM, Rabello A, Zani CL An investigation of the ethanolic extract from stems of Caesalpinia echinata Lam (Leguminosae-Caesalpinioideae) led to the isolation of five new cassane diterpenes along with known lambertianic acid. Their structures were determined based on spectroscopic methods. A preliminary study on leishmanicidal activity demonstrated that compounds 1, 2 and 6 were found to inhibit the growth of amastigote-like forms of Leishmania amazonensis without affecting mononuclear cells obtained from human peripheral blood. PMID: 21641971 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=4945911 Thu, 26 May 2011 23:00:00 +0100 4945911 http://www.medworm.com/index.php?rid=4945910&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21641972%26dopt%3DAbstract Authors: Chanakul W, Tuchinda P, Anantachoke N, Pohmakotr M, Piyachaturawat P, Jariyawat S, Suksen K, Jaipetch T, Nuntasaen N, Reutrakul V Bioassay-guided fractionation of the cytotoxic ethyl acetate extract from the stems of Dasymaschalon blumei (Annonaceae) led to the isolation of four aristololactam alkaloids, including the hitherto unknown 3,5-dihydroxy-2,4-dimethoxyaristolactam (1), as well as the three known compounds, aristolactam BI, goniopedaline, and griffithinam. Additionally, the cytotoxic extract from the combined leaves and twigs of the same plant yielded three known oxoaporphine alkaloids, oxodiscoguattine, dicentrinone, and duguevalline. The structures of aristolactams and oxoaporphine alkaloids were elucidated on the basis of spectroscopic methods. All isolates were ev... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=4945910 Thu, 26 May 2011 23:00:00 +0100 4945910 http://www.medworm.com/index.php?rid=4945909&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21641973%26dopt%3DAbstract Authors: Xiao W, Li X, Li N, Bolati M, Wang X, Jia X, Zhao Y Bioassay-directed separation of the ethyl acetate extract from the aerial parts of Saussurea involucrata (Kar. et Kir. ex Maxim) led to the isolation of three new sesquiterpene lactones sausinlactones A (1), B (2), C (3) and six known ones (4-9). The structures were established by spectroscopic data (UV, IR, HRESIMS, 1D and 2D NMR). CD technique was also employed to determine the absolute configurations of new compounds 1-3. The anti-inflammatory activities of compounds 1-9 and antitumor activities of new compounds 1-3 were tested. The results presented that compounds 5 and 6 were responsible for anti-inflammatory activities, and compounds 1 and 2 showed significant cytotoxic activities against A549 cells. PMID: 21641973 ... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=4945909 Thu, 26 May 2011 23:00:00 +0100 4945909 http://www.medworm.com/index.php?rid=4897461&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21624442%26dopt%3DAbstract Authors: Chatuphonprasert W, Sangkawat T, Nemoto N, Jarukamjorn K Impacts of berberine, a major isoquinoline alkaloid in herbal plants, on beta-naphthoflavone (BNF)-induced CYP1A expression were determined both in primary mouse hepatocytes and in vivo. Berberine concentration-dependently suppressed BNF-induced CYP1A expression in mouse hepatocyte and it significantly down-regulated BNF-induced CYP1A in mouse liver via suppression of mRNA and protein expression, and decreases of EROD and MROD activities. Moreover, berberine showed significant potential on suppression of BNF-induced lipid peroxidation in mouse hepatic microsome. Therefore, using berberine as a health supplement or an alternative medication might provide extra-benefit due to its inhibitory regulation on CYP1A expression a... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=4897461 Sun, 22 May 2011 23:00:00 +0100 4897461 http://www.medworm.com/index.php?rid=4897460&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21624443%26dopt%3DAbstract Authors: Julianti T, Hata Y, Zimmermann S, Kaiser M, Hamburger M, Adams M In the course of a larger screen of 1800 plant and fungal extracts, the ethyl acetate extract of Saussurea costus roots potently inhibited the growth of Trypanosoma brucei rhodesiense. Subsequent HPLC based activity profiling led to the identification of the sesquiterpene lactones arbusculin B (1), α-cyclocostunolide (2), costunolide (3), and dehydrocostuslactone (4). They were tested for in vitro antitrypanosomal activities and cytotoxicity alongside the structurally related sesquiterpene lactones parthenolide (5), zaluzanin D (6), and eupatoriopicrin (7), and had IC(50)s between 0.8 and 22μM. Cytotoxic IC(50)s were from 1.6 to 19μM, and selectivity indices from 0.5 to 6.5. PMID: 21624443 [PubMed - as sup... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=4897460 Sun, 22 May 2011 23:00:00 +0100 4897460 http://www.medworm.com/index.php?rid=4897459&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21624444%26dopt%3DAbstract Authors: Niu XF, Liu X, Pan L, Qi L One new olean-13(18)-ene-3,12,19-trione (1), and two known oleanene triterpenes δ-amyrone (2), and δ-amyrine acetate (3) were isolated from the petroleum ether fraction from an alcoholic extract of the whole plant of Sedum linear Thunb. The new compound was characterized by means of spectroscopic methods including 1D, 2D NMR and HR-ESI-MS, and was further confirmed by X-ray diffraction analysis. The known ones were established on the basis of comparing their NMR data with those of the corresponding compounds in the literature. In addition, the inhibitory effects of the compounds isolated on the TNF-α and NO production were examined in vitro. PMID: 21624444 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=4897459 Sun, 22 May 2011 23:00:00 +0100 4897459 http://www.medworm.com/index.php?rid=4897458&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21635940%26dopt%3DAbstract Authors: Mvondo MA, Njamen D, Fomum ST, Wandji J, Vollmer G To determine whether the two major compounds of Erythrina lysistemon are active principles accounting for Erythrina estrogenic effects, we used a postmenopause-like model of ovariectomized Wistar rats to evaluate their effects on some menopausal problems. Ovariectomized rats were orally treated either with compound 1 or compound 2 at 1 and 10mg/kg BW for 28days. Estradiol valerate served as the reference substance. As results, compounds 1 and 2 displayed estrogen-like effects on the uterus and the vagina, and reduced atherogenic risks by decreasing the two assessed atherogenic parameters, the total cholesterol/HDL-cholesterol ratio and the atherogenic index of plasma. PMID: 21635940 [PubMed - as supplied by publisher] (Sou... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=4897458 Sun, 22 May 2011 23:00:00 +0100 4897458 http://www.medworm.com/index.php?rid=4897457&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21635941%26dopt%3DAbstract Authors: Antognoni F, Perellino NC, Crippa S, Dal Toso R, Danieli B, Minghetti A, Poli F, Pressi G 3,5-O-dicaffeoyl-4-O-malonilquinic acid (1) (irbic acid) has been isolated for the first time from cell cultures of Centella asiatica and till now it has never been reported to be present in the intact plant. Evidence of its structure was obtained by spectroscopic analyses (MS/NMR). Besides 1, cell cultures produce also the known 3,5-O-dicaffeoylquinic acid, chlorogenic acid, and the triferulic acid 2 (4-O-8'/4'-O-8″-didehydrotriferulic acid). Biological activities were evaluated for compound 1, which showed to have a strong radical scavenging capacity, together with a high inhibitory activity on collagenase. This suggests a possible utilization of this substance as a topical agent to r... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=4897457 Sun, 22 May 2011 23:00:00 +0100 4897457 http://www.medworm.com/index.php?rid=4897467&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21605635%26dopt%3DAbstract Authors: Yang NY, Chen JH, Zhou GS, Tang YP, Duan JA, Tian LJ, Liu XH Two new pentacyclic triterpenes and eight known pentacyclic triterpenes were isolated from the petroleum ether extract of Liquidambaris Resina. The structural elucidation of these compounds was determined by spectroscopic data interpretation. Their cytotoxic and antiplatelet aggregation activities were examined to find potent cytotoxic and antiplatelet aggregation compounds from natural resources. The results showed that 3-keto oleane triterpenes had strong cytotoxicity against MDA-MB-435S cancer cells and that 28-carboxyl oleane triterpenes possessed significant inhibition of platelet aggregation induced by ADP. PMID: 21605635 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=4897467 Fri, 13 May 2011 23:00:00 +0100 4897467 http://www.medworm.com/index.php?rid=4897466&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21605636%26dopt%3DAbstract Authors: Choi YJ, Yoon JH, Cha SW, Lee SG Ginsenoside Rh1 has been reported to possess antiallergic and anti-inflammatory activities, but its effects on monocytes remain to be determined. Herein, we investigated the effects of Rh1 on the expression of MCP-1 and CCR2, activation of MAPK signaling, and chemotaxis of monocytes. Treatment of Rh1 decreased the levels of MCP-1 and CCR2 and the expression of VLA5 and activated β1 integrin on the cell surface, and attenuated the phosphorylation of MAPKs. Based on these results, the inhibitory effects of Rh1 on monocyte function should be regarded as a promising new anti-inflammatory response with a potential therapeutic role against inflammation-dependent diseases. PMID: 21605636 [PubMed - as supplied by publisher] (Source: Fitoterapia) Fitoterapia journals http://www.medworm.com/rss/comments.php?id=4897466 Fri, 13 May 2011 23:00:00 +0100 4897466 http://www.medworm.com/index.php?rid=4897465&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21605637%26dopt%3DAbstract Authors: Tang DQ, Wei YQ, Yin XX, Lu Q, Hao HH, Zhai YP, Wang JY, Ren J Quercetin's protective effects on the glomerulosclerosis of diabetic nephropathy (DN) in rat mesangial cells were investigated. The cell cycles, type IV collagen and laminin, TGF-β(1) mRNA, Smad 2/3 and Smad 7, and activities of cell antioxidases were measured. Compared with the high glucose group, quercetin may decrease the cell percentages of G(0)/G(1) phase, Smad 2/3 expression, laminin and type IV collagen, and TGF-β(1) mRNA level significantly. The antioxidant capacity, the cell percentages of S phase and Smad 7 expression was significantly increased by quercetin. These results suggest that quercetin is a protective agent against glomerulosclerosis in DN. PMID: 21605637 [PubMed - as supplied by publisher... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=4897465 Fri, 13 May 2011 23:00:00 +0100 4897465 http://www.medworm.com/index.php?rid=4897464&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21605638%26dopt%3DAbstract Authors: Zhan Y, Zhang Y, Chen Y, Wang N, Zheng L, He L The aim of our study was to investigate the effect of taspine isolated from Radix et Rhizoma Leonticsi on the growth of oestrogen-receptor-positive breast cancer xenografts in vivo and the possible mechanism for this action. In vivo taspine studies were conducted with ZR-75-30 human breast cancer xenografts in athymic mice, and then tumors tissue lysates were subjected to Western blotting analysis of estrogen receptor (ER) and progesterone receptor (PR), which was related to inhibition of tumor growth. For in vitro study, cell proliferation, cell cycle and apoptosis of ZR-75-30 cell treated with or without taspine were detected. ER and PR expression were detected by Western blotting, ER and PR mRNA were verified by reverse transcr... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=4897464 Fri, 13 May 2011 23:00:00 +0100 4897464 http://www.medworm.com/index.php?rid=4897463&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21605639%26dopt%3DAbstract Authors: Bertoglio JC, Calvo MA, Hancke JL, Burgos RA, Riva A, Morazzoni P, Ponzone C, Magni C, Duranti M A lupin seed γ-conglutin-enriched preparation was tested in a glucose overload trial with both murine models and adult healthy volunteers. The results with rats showed a dose-dependent significant decrease of blood glucose concentration, which confirmed previous findings obtained with the purified protein. Moreover, three test-product doses equivalent to 630, 315, and 157.5mg γ-conglutin, orally administered 30min before the carbohydrate supply, showed a relevant hypoglycemic effect in human trials. Insulin concentrations were not significantly affected. The general hematic parameters did not change at all. This is the first report on the glucose-lowering effect of lupin γ-congl... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=4897463 Fri, 13 May 2011 23:00:00 +0100 4897463 http://www.medworm.com/index.php?rid=4897462&cid=s_37058_60_f&fid=37058&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21605640%26dopt%3DAbstract Authors: Tschiggerl C, Bucar F Combinations of thyme, cowslip and liquorice roots are often used in the treatment of upper respiratory tract infections. Therefore the volatile fraction of herbal teas prepared from thyme (Thymus vulgaris) and the effect of combining with cowslip (Primula veris/P. elatior) and liquorice roots (Glycyrrhiza glabra) on the volatiles were analyzed. Volatile compounds were isolated by hydrodistillation and solid phase extraction and analyzed by GC-MS. Thymol was also quantified by HPLC. The total amount of volatiles as well the thymol content was decreased with increasing proportions of cowslip or liquorice in the infusion extracts whereas the proportion of monoterpene hydrocarbons increased. PMID: 21605640 [PubMed - as supplied by publisher] (Source: Fit... Fitoterapia journals http://www.medworm.com/rss/comments.php?id=4897462 Fri, 13 May 2011 23:00:00 +0100 4897462