MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Gastric Cancer' source. Fri, 05 Mar 2010 14:22:10 +0100 http://www.medworm.com/index.php?rid=3154607&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F972766pp20t35001%2F Conclusion  In the present study, with a limited sample size of subjects with low HCA exposure, no association was found between HCA intake and stomach cancer, nor was there any evidence of any influence by genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 on the risk of stomach cancer. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-009-0523-xAuthors Minatsu Kobayashi, National Cancer Center Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening 5-1-1 Tsukiji, Chuo-ku Tokyo 104-0045 JapanTetsuya Otani, National Cancer Center Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening 5-1-1 Tsukiji, Chuo-ku Tokyo 104-0045 JapanMotoki Iwasaki, National Cancer Center Epidemiology and... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=3154607 Mon, 04 Jan 2010 06:46:25 +0100 3154607 http://www.medworm.com/index.php?rid=3154608&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg4266v3617890518%2F Abstract  Gastric cancer is the second leading cause of cancer-related death worldwide, but the details of gastric carcinogenesis remain unclear. In humans, two preneoplastic metaplasias are associated with the precancerous stomach: intestinal metaplasia and spasmolytic polypeptide-expressing metaplasia (SPEM). While mouse models of Helicobacter sp. infection have not shown intestinal metaplasia, a number of mouse models lead to the evolution of SPEM. In this review, we summarize increasing data that indicates that SPEM arises in the setting of parietal cell loss, either following acute druginduced oxyntic atrophy or in chronic oxyntic atrophy associated with H. felis infection. Importantly, recent investigations support the origin of SPEM through transdifferentiation from ma... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=3154608 Mon, 04 Jan 2010 06:46:22 +0100 3154608 http://www.medworm.com/index.php?rid=3154609&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F002p300573117616%2F Conclusion  The present study has enabled a clearer understanding of the significance of tumor color in relation to the AFI imaging of EGCs. Recognition of the color patterns in AFI images should help in the diagnosis of EGCs. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-009-0529-4Authors Motohiko Kato, Osaka University Graduate School of Medicine Department of Gastroenterology and Hepatology Osaka JapanNoriya Uedo, Osaka Medical Center for Cancer and Cardiovascular Diseases Department of Gastrointestinal Oncology 1-3-3 Nakamichi, Higashinari-ku Osaka 537-8511 JapanRyu Ishihara, Osaka Medical Center for Cancer and Cardiovascular Diseases Department of Gastrointestinal Oncology 1-3-3 Nakamichi, Higashinari-ku Osaka 537-8511 JapanTakashi Kizu, O... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=3154609 Mon, 04 Jan 2010 06:46:19 +0100 3154609 http://www.medworm.com/index.php?rid=3154610&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy706xv43237tm640%2F Abstract  Gastrointestinal stromal tumor (GIST) is considered to be driven by a gain-of-function mutation in the KIT or PDGFRA gene. Cure can be obtained only by complete surgical removal of the GIST; however, imatinib, an inhibitor of KIT and PDGFRA, is indicated for advanced, recurrent, and/or metastatic GISTs. Imatinib exhibited remarkable clinical effects on advanced GISTs, with substantial tolerability. Its efficacy greatly depends on the genotype of GIST. The drug, however, met intrinsic or acquired resistance during the treatment, of which the molecular mechanisms were mostly dependent on the genotype of GIST, including primary mutations or secondary mutations in the kinase domains of the corresponding target genes, respectively. Although sunitinib had substantial eff... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=3154610 Mon, 04 Jan 2010 06:46:18 +0100 3154610 http://www.medworm.com/index.php?rid=3154611&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp6784t22652175w8%2F Conclusion  The combination chemotherapy of doxifluridine and docetaxel was well tolerated and relatively effective when used as a second-line chemotherapy for advanced or recurrent gastric cancer. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-009-0528-5Authors Takaki Yoshikawa, Kanagawa Cancer Center Department of Gastrointestinal Surgery 1-1-2 Nakao, Asahi-ku Yokohama 241-0815 JapanAkira Tsuburaya, Kanagawa Cancer Center Department of Gastrointestinal Surgery 1-1-2 Nakao, Asahi-ku Yokohama 241-0815 JapanKen Shimada, Showa University Northern Yokohama Hospital Department of Internal Medicine Yokohama JapanAtsushi Sato, Showa University Hospital Department of Medical Oncology Tokyo JapanMakoto Takahashi, Kamishirane Hospital Department of Surge... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=3154611 Mon, 04 Jan 2010 06:46:15 +0100 3154611 http://www.medworm.com/index.php?rid=3154612&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff02t0641vq7168pm%2F Conclusion  Weekly paclitaxel administration shows activity against advanced gastric cancer also in the third-line setting. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-009-0524-9Authors Rai Shimoyama, Shizuoka Cancer Center Division of Gastrointestinal Oncology 1007 Shimonagakubo, Nagaizumi-cho Shizuoka 411-8777 JapanHirofumi Yasui, Shizuoka Cancer Center Division of Gastrointestinal Oncology 1007 Shimonagakubo, Nagaizumi-cho Shizuoka 411-8777 JapanNarikazu Boku, Shizuoka Cancer Center Division of Gastrointestinal Oncology 1007 Shimonagakubo, Nagaizumi-cho Shizuoka 411-8777 JapanYusuke Onozawa, Shizuoka Cancer Center Division of Gastrointestinal Oncology 1007 Shimonagakubo, Nagaizumi-cho Shizuoka 411-8777 JapanShuichi Hironaka, Shizuoka Cancer... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=3154612 Mon, 04 Jan 2010 06:46:12 +0100 3154612 http://www.medworm.com/index.php?rid=3154613&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F74581458wl86t8gt%2F Abstract  This is the first case of gastric schwannoma that exhibited increased accumulation of [(18)F] fluorodeoxyglucose (FDG) on positron emission tomography (PET) imaging. The patient was a 60-year-old woman in whom esophagogastroduodenoscopy showed a submucosal tumor, about 25 mm in size, in the upper body of the stomach, with ulceration at the top of the tumor. Endoscopic ultrasonography revealed a well-defined hypoechoic mass located in the proper muscle layer of the stomach. The specimen taken from the tumor showed only inflammatory degenerative tissue. Abdominal computed tomography revealed a tumor in the upper body of the stomach. FDG-PET showed FDG uptake (standardized uptake value [SUV] max 5.8) coincident with the tumor. Hence, the tumor was diagnosed initially... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=3154613 Mon, 04 Jan 2010 06:46:11 +0100 3154613 http://www.medworm.com/index.php?rid=2968801&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fnr49777655441485%2F Conclusion  MTX/5FU chemotherapy may be effective in treating peritoneal dissemination of gastric cancer and might improve the patient’s condition in terms of reducing ascites and improving oral intake. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-009-0517-8Authors Masako Imazawa, Shizuoka Cancer Center Division of Gastrointestinal Oncology 1007 Shimonagakubo, Nagaizumi-cho Shizuoka 411-8777 JapanTakashi Kojima, Shizuoka Cancer Center Division of Gastrointestinal Oncology 1007 Shimonagakubo, Nagaizumi-cho Shizuoka 411-8777 JapanNarikazu Boku, Shizuoka Cancer Center Division of Gastrointestinal Oncology 1007 Shimonagakubo, Nagaizumi-cho Shizuoka 411-8777 JapanYusuke Onozawa, Shizuoka Cancer Center Division of Gastrointestinal Oncology 1007 Sh... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2968801 Wed, 04 Nov 2009 21:57:25 +0100 2968801 http://www.medworm.com/index.php?rid=2968802&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F67872328v878l52p%2F Abstract  Laparoscopic gastrectomy is widely used as minimally invasive surgery for gastric carcinoma. Billroth I or Roux-en-Y reconstruction is commonly performed after laparoscopic distal gastrectomy (LDG). Roux-en-Y reconstruction after LDG is one of the best methods for reconstruction of the alimentary tract when Billroth I reconstruction is difficult. There are few reports of intracorporeal Roux-en-Y reconstruction after LDG because of the technical difficulties of such a procedure. In particular, in the case of a very small gastric remnant, gastrojejunostomy using endoscopic linear staplers becomes more complicated. We developed a new technique for intracorporeal Roux-en-Y reconstruction: a modified stapling technique to allow the gastrojejunostomy to be made on the s... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2968802 Wed, 04 Nov 2009 21:57:19 +0100 2968802 http://www.medworm.com/index.php?rid=2968803&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm1k63873415u5067%2F We report a rare case of metastatic gastric tumor derived from right renal carcinoma. Gastric endoscopy confirmed a large, polypoid, friable mass (type 1 tumor, about 7 cm in diameter) in the middle part of the stomach body. The mass was surgically excised and pathological examination showed that the gastric tumor was derived from a metastasis from the right kidney, because it was composed of malignant cells that were identical to those from the removed RCC. In addition, the tumor cells were immunoreactive for CD10, CD15, Ecadherin, early membrane antigen (EMA), and vimentin, but no reactivity was observed for cytokeratins 7 and 20 or c-KIT. Although gastric metastatic tumor derived from renal carcinoma is rare, the precise pre- and postoperative diagnosis may be important; thus, in... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2968803 Wed, 04 Nov 2009 21:57:14 +0100 2968803 http://www.medworm.com/index.php?rid=2968804&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd84u704762r65334%2F Conclusion  Local lidocaine injections into the submucosal layer were safe when administered during ESDs performed on EGC patients under sedation. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-009-0514-yAuthors Shinsuke Kiriyama, National Cancer Center Hospital Endoscopy Division 5-1-1 Tsukiji, Chuo-ku Tokyo 104-0045 JapanIchiro Oda, National Cancer Center Hospital Endoscopy Division 5-1-1 Tsukiji, Chuo-ku Tokyo 104-0045 JapanFumiya Nishimoto, National Cancer Center Hospital Endoscopy Division 5-1-1 Tsukiji, Chuo-ku Tokyo 104-0045 JapanYumi Mashimo, National Cancer Center Hospital Endoscopy Division 5-1-1 Tsukiji, Chuo-ku Tokyo 104-0045 JapanHisatomo Ikehara, National Cancer Center Hospital Endoscopy Division 5-1-1 Tsukiji, Chuo-ku Tokyo 104-00... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2968804 Wed, 04 Nov 2009 21:57:10 +0100 2968804 http://www.medworm.com/index.php?rid=2968805&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F54831jk1466g124n%2F Conclusion  The PG test method alone with a PGI cutoff level of ≤30 ng/ml and PGI/PGII ≤ 2.0 is not appropriate for gastric cancer screening. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-009-0522-yAuthors Shigeto Mizuno, Kobe Pharmaceutical University Department of Medical Pharmaceutics Kobe JapanMasao Kobayashi, Kyoto Second Red Cross Hospital Department of Health Care Kyoto JapanShohken Tomita, Kansai Occupational Health Association Osaka JapanIkuya Miki, Kobe Pharmaceutical University Department of Medical Pharmaceutics Kobe JapanAtsuhiro Masuda, Kobe Pharmaceutical University Department of Medical Pharmaceutics Kobe JapanMitsuko Onoyama, Kobe Pharmaceutical University Department of Medical Pharmaceutics Kobe JapanYasuki Habu, Saiseikai ... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2968805 Wed, 04 Nov 2009 21:57:03 +0100 2968805 http://www.medworm.com/index.php?rid=2968806&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv52730513836666j%2F Conclusion  UD-type intramucosal EGC 20 mm or less in size without lymphatic-vascular capillary involvement and ulcerative findings presents a negligible risk of lymph node metastasis. We propose that in this circumstance ER could be considered. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-009-0515-xAuthors Toshiaki Hirasawa, Japanese Foundation for Cancer Research Department of Gastroenterology, Cancer Institute Hospital 3-10-6 Ariake, Koto-ku Tokyo 135-8550 JapanTakuji Gotoda, National Cancer Center Hospital Department of Endoscopy Tokyo JapanSatoshi Miyata, Japanese Foundation For Cancer Research Bioinformatics Group, Genome Center Tokyo JapanYou Kato, Japanese Foundation for Cancer Research Department of Pathology, Cancer Institute Hospita... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2968806 Wed, 04 Nov 2009 21:56:54 +0100 2968806 http://www.medworm.com/index.php?rid=2968807&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Flxk0h48654706006%2F Abstract  The only potentially curative treatment available for gastric adenocarcinoma is surgical resection. However, many controversies exist regarding treatment strategy, including whether the laparoscopic approach is appropriate. Many reports of laparoscopic techniques for cancer resection have shown oncologic equivalency to the open technique, with the known benefits of the minimally invasive approach, such as decreased pain, length of hospital stay, blood loss, and complications. The Eastern experience with laparoscopic gastrectomy has been extensive, associated with the increased incidence of early gastric cancers. However, in the West, laparoscopic approaches for gastric cancer have been more slowly accepted, largely due to the lower incidence of gastric cancer in t... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2968807 Wed, 04 Nov 2009 21:56:48 +0100 2968807 http://www.medworm.com/index.php?rid=2968808&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fcr26566t58x7m281%2F Abstract  A globally accepted standard chemotherapy remains undetermined in gastric cancer, but the recent introduction of active “new-generation agents” such as taxanes, irinotecan (CPT-11), oxaliplatin, S-1, and capecitabine, offers hope for markedly improving patient outcomes. Docetaxel, as well as the other new-generation agents, plays a key role in the development of the new-era chemotherapy, and the incorporation of taxanes has provided several regimens, such as docetaxel/cisplatin/5-fluorouracil (5-FU) (DCF), that could become standard treatment. The DCF regimen is now regarded as a standard treatment option in advanced gastric cancer in selected patients in good condition. Many institutions and cooperative groups continue to study a variety of docetaxel-based co... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2968808 Wed, 04 Nov 2009 21:56:33 +0100 2968808 http://www.medworm.com/index.php?rid=2968809&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F488801r3445475p0%2F Content Type Journal ArticleCategory EditorialDOI 10.1007/s10120-009-0518-7Authors Seigo Kitano, Oita University Faculty of Medicine Department of Surgery I 1-1 Idaigaoka, Yufu Oita 879-5593 Japan Journal Gastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal Volume Volume 12 Journal Issue Volume 12, Number 3 / October, 2009 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2968809 Wed, 04 Nov 2009 21:56:21 +0100 2968809 http://www.medworm.com/index.php?rid=2557950&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw367206j4635t084%2F Abstract  A comprehensive review of phase I and phase II clinical trials of paclitaxel and paclitaxel-containing chemotherapy regimens for advanced gastric cancer was performed. Response rates, median progression-free survivals, and median overall survivals were examined, together with the treatment regimens and the numbers of patients registered in each trial. Although paclitaxel monotherapy produced considerable improvement in tumor response and prognosis, combination doublet or triplet chemotherapy with fluoropyrimidines and/or platinum compounds showed better results than the paclitaxel monotherapy. With regard to the schedule of paclitaxel administration, weekly injection seemed to show less toxicity and better results than administration every 3 weeks. Adjuvant therap... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2557950 Mon, 29 Jun 2009 13:47:56 +0100 2557950 http://www.medworm.com/index.php?rid=2557951&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fdu2v13752g756257%2F Abstract  Laparoscopy-assisted distal gastrectomy (LADG) with extended lymph node dissection has not yet been widely adopted for the treatment of gastric cancers because of the perceived complexity of the procedure. Suprapancreatic lymph node dissection is one of the most important and demanding procedures in this approach. The techniques of duodenal transection within the abdominal cavity or taping of the common hepatic or splenic artery had traditionally been adopted for suprapancreatic nodal dissection during open surgery. In 2005, we developed a new laparoscopic procedure to safely and simply perform suprapancreatic lymph node dissection in LADG. We introduced a left-sided approach for the dissection of lymph nodes in the left gastropancreatic fold, where the body of th... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2557951 Mon, 29 Jun 2009 13:47:49 +0100 2557951 http://www.medworm.com/index.php?rid=2557952&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv65g264250846u40%2F Abstract  Duodenal cancer is an uncommon neoplasm and it mostly arises from the periampullary area. However, metachronous or even recurrent cancer at the duodenal stump following Billroth II type distal gastrec tomy for gastric cancer is extremely rare and, to our knowledge, has not yet been reported. A 68-year-old man underwent Billroth II distal gastrectomy with D2 lymph node dissection for an advanced gastric cancer. At that time the tumor stage was T2bN3M0, with 44 of 78 retrieved lymph nodes showing metastasis. He was well without recurrence for 3 years; however, he visited our hospital because of the abrupt onset of dizziness and tarry stool. A polypoid tumor that bled easily when touched was found at the end of the afferent loop of the duodenal stump by gastrofibersc... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2557952 Mon, 29 Jun 2009 13:47:42 +0100 2557952 http://www.medworm.com/index.php?rid=2557953&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc67582715q022xwv%2F This report documents a 59-year-old Japanese man with CCS who underwent a total gastrectomy for gastric tumors. The resected specimen showed a huge gastric adenocarcinoma with numerous polyps throughout the stomach. The cancer was pathologically limited to within the mucosa and its histological structure resembled that of hyperplasia in CCS polyps, which led us to suppose that the carcinoma had arisen from hyperplastic CCS polyps. These results urged us to study the phenotypic expression of mucins, which revealed MUC2(−) and MUC5AC(+) and supported the diagnosis of the tumor as a gastric-type well-differentiate adenocarcinoma. A literature search revealed that 32 gastric carcinomas which developed in patients with CCS were mostly limited to within the submucosa in spite of their hu... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2557953 Mon, 29 Jun 2009 13:47:36 +0100 2557953 http://www.medworm.com/index.php?rid=2557954&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu00m8n3363kw7962%2F We describe a new double-stapling technique for esophagojejunostomy and esophagogastrostomy, using a peroral intraluminal approach with a digital stapling system, a flexible shaft remote-control stapler — the Surg-ASSIST and Power Circular Stapler 21 mm (PCS). The overtube of the flexible shaft of the PCS is prepared with a nylon tie and secured to a nasogastric (NG) tube. The flexible shaft is manually advanced down the esophagus with guidance by pulling the NG tube from the abdominal cavity side. The trocar of the flexible shaft is removed from the stump of the abdominal esophagus and connected to the anvil and they are approximated; the stapler device is then fired to form a double-stapled esophagojejunostomy and esophagogastrostomy. Our peroral intraluminal approach does not re... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2557954 Mon, 29 Jun 2009 13:47:29 +0100 2557954 http://www.medworm.com/index.php?rid=2557956&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F381840517653tj51%2F Conclusion  Gastric stump carcinoma following proximal gastrectomy occurred at a high frequency of 5.4% of initial resections. It is necessary to select a reconstruction method that facilitates postoperative endoscopic examination, as well as to follow up the patients after proximal gastrectomy in the long term for the early detection and early treatment of gastric stump carcinoma. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-009-0502-2Authors Shigekazu Ohyama, Cancer Institute Hospital of JFCR Department of Surgery 3-10-6 Ariake, Koto-ku Tokyo 135-8550 JapanMasanori Tokunaga, Cancer Institute Hospital of JFCR Department of Surgery 3-10-6 Ariake, Koto-ku Tokyo 135-8550 JapanNaoki Hiki, Cancer Institute Hospital of JFCR Department of Surgery 3... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2557956 Mon, 29 Jun 2009 13:47:21 +0100 2557956 http://www.medworm.com/index.php?rid=2557955&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb73116708vw66l62%2F Conclusion  These findings indicate that serum IL-6 may suggest gastric cancer progression. On the other hand, IL-10 may play an important role in host immunity and the prognosis of GC patients. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-009-0509-8Authors Masahide Ikeguchi, Tottori University Department of Surgery, Division of Surgical Oncology, Faculty of Medicine 36-1 Nishi-cho Yonago 683-8504 JapanTomoko Hatada, Tottori University Department of Surgery, Division of Surgical Oncology, Faculty of Medicine 36-1 Nishi-cho Yonago 683-8504 JapanManabu Yamamoto, Tottori University Department of Surgery, Division of Surgical Oncology, Faculty of Medicine 36-1 Nishi-cho Yonago 683-8504 JapanTakanori Miyake, Tottori University Department of Surgery... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2557955 Mon, 29 Jun 2009 13:47:21 +0100 2557955 http://www.medworm.com/index.php?rid=2557957&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj14127h0w3j134r2%2F Abstract   Helicobacter pylori is now well known as an important pathogen related to the development of gastric cancer. However, some clinicians still doubt the causal association of H. pylori with the development of gastric cancer. To summarize the recent clinical data on the link between H. pylori and gastric cancer, we reviewed related articles published over the past 3 years, after the award of the Nobel Prize for Physiology or Medicine to Drs. J.R. Warren and B.J. Marshall for the first culture and isolation of H. pylori and the investigation of their relevance to peptic ulcer disease. This updated summary of the relationship between H. pylori and gastric cancer highlights the strong link between the organism and the development of gastric cancer, and suggests eradication... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2557957 Mon, 29 Jun 2009 13:47:16 +0100 2557957 http://www.medworm.com/index.php?rid=2557958&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa1h2443554228tt2%2F Content Type Journal ArticleCategory EditorialDOI 10.1007/s10120-009-0512-0Authors Seigo Kitano, Oita University Faculty of Medicine Department of Surgery I 1-1 Idaigaoka, Yufu Oita 879-5593 Japan Journal Gastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal Volume Volume 12 Journal Issue Volume 12, Number 2 / June, 2009 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2557958 Mon, 29 Jun 2009 13:47:10 +0100 2557958 http://www.medworm.com/index.php?rid=2557959&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh1nt7051p28xkv13%2F Content Type Journal ArticleCategory AnnouncementDOI 10.1007/s10120-009-0513-z Journal Gastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal Volume Volume 12 Journal Issue Volume 12, Number 2 / June, 2009 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2557959 Mon, 29 Jun 2009 13:47:01 +0100 2557959 http://www.medworm.com/index.php?rid=2367847&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F30553t37t5450qk8%2F Content Type Journal ArticleCategory From the New Editors-in-ChiefDOI 10.1007/s10120-009-0504-0Authors Hubert J. Stein, Klinikum Nuernberg Department of Surgery Nuremberg Germany Journal Gastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal Volume Volume 12 Journal Issue Volume 12, Number 1 / April, 2009 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2367847 Fri, 24 Apr 2009 07:03:50 +0100 2367847 http://www.medworm.com/index.php?rid=2367850&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F92547q5321185556%2F Content Type Journal ArticleCategory Meeting ReportDOI 10.1007/s10120-009-0499-6Authors William Allum, Royal Marsden NHS Foundation Trust Department of Surgery Fulham Road London SW3 6JJ UKAlfredo Garofalo, Royal Marsden NHS Foundation Trust Department of Surgery Fulham Road London SW3 6JJ UKMaurizio Degiuli, Royal Marsden NHS Foundation Trust Department of Surgery Fulham Road London SW3 6JJ UKChristoph Schuhmacher, Royal Marsden NHS Foundation Trust Department of Surgery Fulham Road London SW3 6JJ UK Journal Gastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal Volume Volume 12 Journal Issue Volume 12, Number 1 / April, 2009 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2367850 Fri, 24 Apr 2009 07:03:49 +0100 2367850 http://www.medworm.com/index.php?rid=2367849&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr7678n1788275775%2F Content Type Journal ArticleCategory From the New Editors-in-ChiefDOI 10.1007/s10120-009-0503-1Authors Yuko Kitagawa, Keio University School of Medicine Department of Surgery 35 Shinanomachi, Shinjuku-ku Tokyo 160-8582 Japan Journal Gastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal Volume Volume 12 Journal Issue Volume 12, Number 1 / April, 2009 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2367849 Fri, 24 Apr 2009 07:03:49 +0100 2367849 http://www.medworm.com/index.php?rid=2367848&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fhq12g074668w4330%2F Content Type Journal ArticleCategory ErratumDOI 10.1007/s10120-009-0500-4Authors Radoslaw Pach, Jagiellonian University First Department of General and GI Surgery Krakow PolandAnita Orzel-Nowak, Jagiellonian University Institute of Nursing, Faculty of Health Care Krakow PolandThecla Scully, University Hospital North Staffordshire Stoke-on-Trent, West Midlands UK Journal Gastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal Volume Volume 12 Journal Issue Volume 12, Number 1 / April, 2009 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2367848 Fri, 24 Apr 2009 07:03:49 +0100 2367848 http://www.medworm.com/index.php?rid=2367852&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8p528km021j3l558%2F Conclusion  S-1 neoadjuvant chemotherapy appeared feasible and showed positive effects against scirrhous gastric cancer; however, the survival rate with S-1 did not reach the expected rate required when selecting an agent for a phase III trial to confirm the effectiveness of neoadjuvant chemotherapy against scirrhous gastric cancer. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-008-0496-1Authors Taira Kinoshita, National Cancer Center Hospital East Department of Surgical Oncology 6-5-1 Kashiwanoha, Kashiwa Chiba 277-8577 JapanMitsuru Sasako, Hyogo College of Medicine Department of Surgery Kobe JapanTakeshi Sano, Cancer Institute Hospital Department of Surgery Tokyo JapanHitoshi Katai, National Cancer Center Hospital Department of Surgical Onco... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2367852 Fri, 24 Apr 2009 07:03:48 +0100 2367852 http://www.medworm.com/index.php?rid=2367851&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg41v648738l5302w%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s10120-008-0495-2Authors Zhong-Xin Li, The University of Tokyo Department of Gastrointestinal Surgery 3-7-1 Hongo, Bunkyo-ku Tokyo 113-8655 JapanMichio Kaminishi, The University of Tokyo Department of Gastrointestinal Surgery 3-7-1 Hongo, Bunkyo-ku Tokyo 113-8655 Japan Journal Gastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal Volume Volume 12 Journal Issue Volume 12, Number 1 / April, 2009 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2367851 Fri, 24 Apr 2009 07:03:48 +0100 2367851 http://www.medworm.com/index.php?rid=2367854&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff221282657g7354g%2F Conclusion  These results suggest that plasma TIMP-1 is a strong independent prognosticator for the long-term survival of patients with gastric cancer. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-008-0494-3Authors Takaki Yoshikawa, Kanagawa Cancer Center Department of Gastrointestinal Surgery 1-1-2 Nakao, Asahi-ku Yokohama 241-0815 JapanHaruhiko Cho, Kanagawa Cancer Center Department of Gastrointestinal Surgery 1-1-2 Nakao, Asahi-ku Yokohama 241-0815 JapanAkira Tsuburaya, Kanagawa Cancer Center Department of Gastrointestinal Surgery 1-1-2 Nakao, Asahi-ku Yokohama 241-0815 JapanOsamu Kobayashi, Kanagawa Cancer Center Department of Gastrointestinal Surgery 1-1-2 Nakao, Asahi-ku Yokohama 241-0815 Japan Journal Gastric CancerOnline ISSN 14... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2367854 Fri, 24 Apr 2009 07:03:45 +0100 2367854 http://www.medworm.com/index.php?rid=2367853&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F72677321290t4km2%2F Content Type Journal ArticleCategory EditorialDOI 10.1007/s10120-009-0501-3Authors H. H. Hartgrink, Leiden University Medical Centre Department of Surgery PO Box 9600 2300 RC Leiden The Netherlands Journal Gastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal Volume Volume 12 Journal Issue Volume 12, Number 1 / April, 2009 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2367853 Fri, 24 Apr 2009 07:03:45 +0100 2367853 http://www.medworm.com/index.php?rid=2367857&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fmurm000214262485%2F Conclusion  While other studies have shown risk factors for multiple gastric carcinomas, the present study is unique in showing risk assessment criteria based on a combination of risk factors for multiple gastric carcinomas. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-008-0493-4Authors Toshikatsu Nitta, Osaka Medical College Department of Pathology Osaka JapanYutaro Egashira, Osaka Medical College Department of Pathology Osaka JapanHiroshi Akutagawa, Osaka Medical College Department of Pathology Osaka JapanGo Edagawa, Osaka Medical College Department of Pathology Osaka JapanYoshitaka Kurisu, Osaka Medical College Department of Pathology Osaka JapanEiji Nomura, Osaka Medical College Department of General and Gastroenterological Surgery 2-7 Dai... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2367857 Fri, 24 Apr 2009 07:03:44 +0100 2367857 http://www.medworm.com/index.php?rid=2367856&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm7100055784441x5%2F Conclusion  Tight-junction-associated proteins, particularly claudin-4, may play important roles in determining invasiveness, metastatic potential, and survival in gastric cancer. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-008-0497-0Authors Satoshi Ohtani, Fukushima Medical University Department of Surgery 1 1 Hikarigaoka Fukushima 960-1295 JapanMasanori Terashima, Shizuoka Cancer Center Hospital Department of Gastric Surgery Shizuoka JapanJun Satoh, Fukushima Medical University Department of Surgery 1 1 Hikarigaoka Fukushima 960-1295 JapanNobutoshi Soeta, Fukushima Medical University Department of Surgery 1 1 Hikarigaoka Fukushima 960-1295 JapanZenichiroh Saze, Fukushima Medical University Department of Surgery 1 1 Hikarigaoka Fukushima 960... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2367856 Fri, 24 Apr 2009 07:03:44 +0100 2367856 http://www.medworm.com/index.php?rid=2367855&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe33703067135ww12%2F Conclusion  AUS, EUS, MDCT, conventional MRI, and FDG-PET cannot reliably be used to confirm or exclude the presence of LN metastasis. The performance of highresolution PET/CT fusion and functional MRI techniques still has to be determined. Content Type Journal ArticleCategory Review ArticleDOI 10.1007/s10120-008-0492-5Authors Robert Michael Kwee, Maastricht University Medical Center Department of Radiology P. Debyelaan 25 6202 AZ Maastricht The NetherlandsThomas Christian Kwee, University Medical Center Utrecht Department of Radiology Utrecht The Netherlands Journal Gastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal Volume Volume 12 Journal Issue Volume 12, Number 1 / April, 2009 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2367855 Fri, 24 Apr 2009 07:03:44 +0100 2367855 http://www.medworm.com/index.php?rid=2367858&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd7421327q51j5877%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s10120-009-0498-7Authors Yoshiyuki Hoya, The Jikei University School of Medicine Department of Surgery, Daisan Hospital 4-11-1 Izumihon-cho, Komae Tokyo 201-8601 JapanTetsuya Taki, The Jikei University School of Medicine Department of Surgery, Daisan Hospital 4-11-1 Izumihon-cho, Komae Tokyo 201-8601 JapanMasato Hoshino, The Jikei University School of Medicine Department of Surgery, Daisan Hospital 4-11-1 Izumihon-cho, Komae Tokyo 201-8601 JapanAtsuo Shida, The Jikei University School of Medicine Department of Surgery, Daisan Hospital 4-11-1 Izumihon-cho, Komae Tokyo 201-8601 JapanShuzou Kohno, The Jikei University School of Medicine Department of Surgery, Daisan Hospital 4-11-1 Izumihon-cho, Komae Tokyo 201-8601 Japa... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2367858 Fri, 24 Apr 2009 07:03:43 +0100 2367858 http://www.medworm.com/index.php?rid=2134240&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe120n52r73404418%2F Content Type Journal ArticleDOI 10.1007/s10120-008-0491-6Authors Masaki Kitajima, International University of Health and Welfare Tokyo Japan Journal Gastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal Volume Volume 12 Journal Issue Volume 12, Supplement 1 / January, 2009 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2134240 Sun, 25 Jan 2009 06:46:52 +0100 2134240 http://www.medworm.com/index.php?rid=2134241&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm2711431hp60485k%2F Abstract  S-1, a novel oral fluoropyrimidine, has shown remarkably good tolerability in Korean gastric and colorectal cancer patients due to its favorable safety profile. Myelosuppression and diarrhea were the events that precluded dose escalation in Japan, whereas gastrointestinal toxicity and skin reaction were the major limiting factors in Western countries. In contrast, the major adverse event in Korean patients was anemia, which appeared early in the S-1 treatment period and varied among patients. Conventional comparative genomic hybridization (CGH) is used to screen for chromosomal copy number variations such as gene gain, loss, amplification, and deletion. This technique can provide information about genetic instability and chromosomal rearrangements. However, the lo... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2134241 Sun, 25 Jan 2009 06:46:50 +0100 2134241 http://www.medworm.com/index.php?rid=2134243&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv1242168pu575128%2F Abstract  S-1, developed by the scientific theory of both potentiating the antitumor efficacy of 5-fluorouracil (5-FU) and reducing the gastrointestinal (GI) toxicity induced by 5-FU, is a new oral formulation consisting of 1 M tegafur, 0.4 M gimeracil, and 1 M potassium oteracil. By combining gimeracil, a potent inhibitor of 5-FU degradation, and potassium oteracil, which protects against 5-FU-induced GI toxicity to tegafur, S-1, as a dihydropyrimidine dehydrogenase (DPD)-inhibitory fluoropyrimidine (DIF), showed higher antitumor activity, with low intestinal toxicity, compared to continuous infusion of 5-FU (the most effective dosing schedule for 5-FU) and compared to clinically useful oral fluoropyrimidines in various murine and human tumors. In regard to combinations of... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2134243 Sun, 25 Jan 2009 06:46:49 +0100 2134243 http://www.medworm.com/index.php?rid=2134242&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv4565756082v3765%2F Abstract  Since 2000, several studies have reported positive results in reasonable-size randomized controlled trials of adjuvant treatment for potentially curable gastric cancer. At present, postoperative adjuvant chemoradiotherapy and perioperative chemotherapy are the standard of care in the United States and Europe (including Great Britain), respectively, while postoperative S-1 monotherapy is the standard of care in Japan. The effect of adjuvant treatment varies according to the type of surgery, and the best results so far have been observed in the adjuvant chemotherapy of TS-1 for gastric cancer (ACTS-GC) trial, in which D2 surgery followed by S-1 monotherapy was tested. The role of radiotherapy after D2 dissection remains unclear. Content Type Journal ArticleCategor... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2134242 Sun, 25 Jan 2009 06:46:49 +0100 2134242 http://www.medworm.com/index.php?rid=2134244&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc17147qxl5170461%2F Abstract  S-1, an oral fluoropyrimidine has been considered to be a key drug in the treatment of advanced gastric cancer in Japan as a standard chemotherapy option. Individual variations in the enzyme activity of the 5-FU metabolic pathway can affect the extent of 5-FU metabolism and affect the efficacy of S-1 based chemotherapy. In this review, the role of genetic factors in affecting the therapeutic efficacy of S-1 is discussed, with special emphasis on enzymes involved in the 5-FU metabolic pathway. The gene expressions of thymidylate synthase, thymidine phosphorylase, and orotate phosphoribosyltransferase, in particular, are discussed in relation to the efficacy of S-1 monotherapy. The predictive values of these candidate genes may, however, be overcome when other drugs... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2134244 Sun, 25 Jan 2009 06:46:48 +0100 2134244 http://www.medworm.com/index.php?rid=2134246&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3063u460387p0746%2F Abstract  We reviewed the clinical development of S-1 and S-1 plus cisplatin (CDDP) therapy for advanced gastric cancer (AGC). S-1 is an active oral fluoropyrimidine in patients with AGC. Phase I/II clinical trials of S-1 plus CDDP for AGC have yielded high response rates and the agents were well tolerated. On the basis of these phase I/II studies, we performed a randomized phase III study comparing S-1 plus CDDP with S-1 alone in patients with AGC. In the S-1 plus CDDP group, S-1 was given orally, twice daily for 3 consecutive weeks, and 60 mg/m2 CDDP was given intravenously on day 8, followed by a 2-week rest period, within a 5-week cycle. In the S-1 alone group, S-1 was given orally, twice daily for 4 consecutive weeks, followed by 2 weeks of rest, within a 6-week cycle. ... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2134246 Sun, 25 Jan 2009 06:46:45 +0100 2134246 http://www.medworm.com/index.php?rid=2134245&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft48562q3p6uq481n%2F Abstract  From the late 1980s to the early 1990s, the Gastrointestinal Oncology Study Group of the Japan Clinical Oncology Group (GIOSG/JCOG) conducted several phase II studies, some of which evaluated oral fluoropyrimidines and others of which introduced Western regimens to Japanese patients. Thereafter, in the phase III study JOCG9205 comparing 5-fluorouracil (5-FU), 5-FU plus cisplatin (CDDP) (FP), and uracil and tegafur (UFT) plus mitomycin (UFTM), neither FP nor UFTM showed a survival benefit over 5-FU alone. Whereas irinotecan (CPT-11) and S-1 (new oral fluoropyrimidine) were developed with promising action against gastric cancer in the late 1990s, these agents cannot be used for patients with impaired oral intake and bowel passage caused by severe peritoneal metastas... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2134245 Sun, 25 Jan 2009 06:46:45 +0100 2134245 http://www.medworm.com/index.php?rid=2134248&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa41t22712741x260%2F Abstract  Various combination treatments incorporating S-1 are undergoing clinical trials in Korea, especially combinations with taxane, oxaliplatin, or irinotecan. In a phase I study to estimate the maximum tolerated dose of docetaxel in combination with S-1 administered at a fixed dose of 40 mg/m2 twice daily on days 1–14 of each 3-week cycle in patients with advanced gastric cancer, 60 mg/m2 docetaxel was declared to be the maximum tolerated dose. A phase I/II study of the same schedule of combination chemotherapy with S-1 plus docetaxel reported doses of S-1/docetaxel of 40/75 mg/m2 as the maximum tolerated dose. In a phase I study of S-1 plus weekly docetaxel, the patients received variable doses of docetaxel administered intravenously over 1 h on days 1 and 8 and S-1 ... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2134248 Sun, 25 Jan 2009 06:46:44 +0100 2134248 http://www.medworm.com/index.php?rid=2134247&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj17836608015qp18%2F In this study, phase I/II studies of combination chemotherapy with S-1 and platinum in patients with metastatic or recurrent gastric cancer were reviewed. We found that the combination of S-1 plus cisplatin was highly active against advanced gastric cancer, with a favorable toxicity profile. The response rates were 53%-74% in Japan, 47.6% in Korea, and 51% in the United States and Europe. There is no internationally accepted standard care for patients with advanced gastric cancer yet, but S-1 is likely to replace infusional 5-FU, and oxaliplatin may represent an alternative to cisplatin in the near future. More innovative therapies, particularly with molecular-targeted drugs, are needed to meet the needs of patients in the era of tailored medicine. Content Type Journal ArticleCate... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2134247 Sun, 25 Jan 2009 06:46:44 +0100 2134247 http://www.medworm.com/index.php?rid=2134250&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F92584v378l843u14%2F Abstract  According to the results of two recent randomized studies of treatment for metastatic gastric cancer in Japan, S-1 could replace infusional 5-fluorouracil and S-1 plus cisplatin showed a significant survival advantage over S-1 monotherapy, with a favorable toxicity profile. However, no globally accepted standards have been established yet and we have to wait for the results of other ongoing international studies, including studies of S-1 and its combinations, to achieve such standards. There are two major approaches to achieve further progress in the treatment of advanced gastric cancer. The first is to optimize the use of conventional cytotoxic agents (regimens) in the continuum of treatment for this disease. Several randomized studies of such regimens as second-... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2134250 Sun, 25 Jan 2009 06:46:43 +0100 2134250 http://www.medworm.com/index.php?rid=2134249&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F960311756727gq08%2F Abstract  S-1 and irinotecan (CPT-11) are active agents against gastric cancer. Some preclinical studies have demonstrated the theoretical background of combination therapy with S-1 and CPT-11 for gastric cancer. Based on these findings, several phase I/II studies of this combination therapy, which has been proposed as a candidate of standard treatment for advanced or recurrent gastric cancer in Japan, have been conducted. Although there were slight differences in the administration schedules of the combination therapy with S-1 and CPT-11 in these phase II studies, the response rates were more than 50%, and the median survival time (MST) exceeded 1 year. Also, good safety profiles were reported. These results warranted a further, phase III, study to define the efficacy of t... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2134249 Sun, 25 Jan 2009 06:46:43 +0100 2134249 http://www.medworm.com/index.php?rid=2094373&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh0l06638317k6v58%2F Content Type Journal ArticleCategory EditorialDOI 10.1007/s10120-008-0490-7Authors Yasuhiro Kodera, Nagoya University Graduate School of Medicine Department of Surgery II 65 Tsurumai-cho, Showa-ku Nagoya 466-8550 Japan Journal Gastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal Volume Volume 11 Journal Issue Volume 11, Number 4 / December, 2008 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2094373 Fri, 09 Jan 2009 11:40:35 +0100 2094373 http://www.medworm.com/index.php?rid=2094374&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fqmw8412178452275%2F Abstract  Modern surgery is usually considered to have begun in nineteenth century Europe. One of the most famous contributors to gastric cancer surgery was the Polish surgeon Ludwik Rydygier, born in 1850. He initiated new methods in several fields, such as gastrointestinal surgery, orthopedics, gynecology, and urology. He was the second surgeon in the world to perform an antral resection, which he carried out on November 16, 1880. The patient, a 64-year-old man, suffered from pyloric cancer and died 12 hours after the procedure as a result of postoperative shock. The next pyloric resection was performed by Billroth in Vienna in 1881. In the nineteenth century few gastric resections were performed for peptic ulcer. The first successful antral resection for gastric ulcer pe... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2094374 Fri, 09 Jan 2009 11:40:32 +0100 2094374 http://www.medworm.com/index.php?rid=2094377&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp2706435v443311n%2F Conclusion  When adequately indicated, ESD is a safe and feasible technique. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-008-0489-0Authors Daniela Medeiros Milhomem Cardoso, Araújo Jorge Cancer Hospital Endoscopic Unit, Department of Gastrointestinal Oncology Rua 239, No. 181, Setor Universitário, CEP 74605-070 Goiânia GO BrazilPaulo Moacir de Oliveira Campoli, Araújo Jorge Cancer Hospital Endoscopic Unit, Department of Gastrointestinal Oncology Rua 239, No. 181, Setor Universitário, CEP 74605-070 Goiânia GO BrazilChizu Yokoi, National Cancer Center Hospital Endoscopy Unit Tokyo JapanFlávio Hayato Ejima, Araújo Jorge Cancer Hospital Endoscopic Unit, Department of Gastrointestinal Oncology Rua 239, No. 181, Setor Universitário, CEP 746... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2094377 Fri, 09 Jan 2009 11:40:31 +0100 2094377 http://www.medworm.com/index.php?rid=2094376&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0147366277852228%2F Conclusion  RT-PCR using a panel of tumor markers, including CEA, detects (+) cytology. The clinical significance of “false-positive” overexpression of CEA, survivin, or CK20 but cytology (−) remains to be defined. RT-PCR could represent a more sensitive method than cytology for detection of subclinical peritoneal tumor dissemination; this may be useful in improving patient selection for operative management and clinical trials. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-008-0483-6Authors Kimberly Moore Dalal, Memorial Sloan-Kettering Cancer Center Department of Surgery 1275 York Avenue New York NY 10021 USAYanghee Woo, Memorial Sloan-Kettering Cancer Center Department of Surgery 1275 York Avenue New York NY 10021 USAKaitlyn Kelly, M... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2094376 Fri, 09 Jan 2009 11:40:31 +0100 2094376 http://www.medworm.com/index.php?rid=2094375&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0876k21670105n77%2F Abstract  It is said that laparoscopic esophagoenteral anastomosis is not easy. In particular, purse-string suture of the abdominal esophagus is difficult when using a circular stapler. We have developed an endoscopic purse-string suture instrument, the “Endo-PSI (II)”, and the instrument was employed clinically during laparoscopy-assisted total gastrectomy. The device was inserted into the abdominal cavity through a 4-cm minilaparotomy of the epigastrium, and pneumoperitoneum was established by closing a Lap Disc. The Endo-PSI (II) was attached to the abdominal esophagus and a straight needle with a 2-0 polypropylene suture was passed through the device laparoscopically. After a purse-string suture of the abdominal esophagus was made, the abdominal esophagus was transe... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2094375 Fri, 09 Jan 2009 11:40:31 +0100 2094375 http://www.medworm.com/index.php?rid=2094378&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7254026734952j57%2F Conclusion  Gastric cancers with muscularis propria invasion had heterogeneous prognoses according to the tumor depth in the muscularis propria layers. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-008-0486-3Authors Yu Imamura, Kumamoto University 1 Department of Gastroenterological Surgery, Graduate School of Medical Sciences 1-1-1 Honjo Kumamoto 860-8556 JapanYoshifumi Baba, Kumamoto University 1 Department of Gastroenterological Surgery, Graduate School of Medical Sciences 1-1-1 Honjo Kumamoto 860-8556 JapanShinji Ishikawa, Kumamoto University 1 Department of Gastroenterological Surgery, Graduate School of Medical Sciences 1-1-1 Honjo Kumamoto 860-8556 JapanYukiharu Hiyoshi, Kumamoto University 1 Department of Gastroenterological Surgery, Gr... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2094378 Fri, 09 Jan 2009 11:40:30 +0100 2094378 http://www.medworm.com/index.php?rid=2094380&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm2763917r5r42243%2F Conclusion  IP combination chemotherapy may be an acceptable option for patients with SBA. Further studies are warranted to determine the optimal chemotherapeutic regimen for SBA. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-008-0484-5Authors Makiko Ono, National Cancer Center Hospital Gastrointestinal Oncology Division Tokyo JapanKuniaki Shirao, Oita University Department of Medical Oncology, Faculty of Medicine 1-1 Idaigaoka, Hasama-machi, Yufu Oita 879-5593 JapanAtsuo Takashima, National Cancer Center Hospital Gastrointestinal Oncology Division Tokyo JapanChigusa Morizane, National Cancer Center Hospital Hepatobiliary and Pancreatic Oncology Division Tokyo JapanNatsuko Okita, National Cancer Center Hospital Gastrointestinal Oncology Divisio... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2094380 Fri, 09 Jan 2009 11:40:26 +0100 2094380 http://www.medworm.com/index.php?rid=2094379&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6757154l832l22l8%2F Conclusion  The number of nodes positive for metastasis was the only independent risk factor for recurrence after curative surgery in patients with lymph node-positive early gastric cancer. These high-risk patients may obtain additional survival benefit if targeted with adjuvant chemotherapy. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-008-0485-4Authors Makoto Saka, National Cancer Center Hospital Gastric Surgery Division 5-1-1, Tsukiji, Chuo-ku Tokyo 104-0045 JapanHitoshi Katai, National Cancer Center Hospital Gastric Surgery Division 5-1-1, Tsukiji, Chuo-ku Tokyo 104-0045 JapanTakeo Fukagawa, National Cancer Center Hospital Gastric Surgery Division 5-1-1, Tsukiji, Chuo-ku Tokyo 104-0045 JapanRajwinder Nijjar, Heart of England NHS Foundatio... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2094379 Fri, 09 Jan 2009 11:40:26 +0100 2094379 http://www.medworm.com/index.php?rid=2094381&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv51778796m713775%2F Conclusion  The assessment of lymph node metastases from USPIO-post-contrast MRI alone using the new criteria was useful in the diagnosis of regional lymph node metastases in gastric cancer. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-008-0480-9Authors Takaya Tokuhara, Osaka Medical College Department of General and Gastroenterological Surgery 2-7 Daigaku-machi, Takatsuki Osaka 569-8686 JapanNobuhiko Tanigawa, Osaka Medical College Department of General and Gastroenterological Surgery 2-7 Daigaku-machi, Takatsuki Osaka 569-8686 JapanMitsuru Matsuki, Osaka Medical College Department of Radiology Osaka JapanEiji Nomura, Osaka Medical College Department of General and Gastroenterological Surgery 2-7 Daigaku-machi, Takatsuki Osaka 569-8686 JapanH... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=2094381 Fri, 09 Jan 2009 11:40:25 +0100 2094381 http://www.medworm.com/index.php?rid=1844002&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd50tx54015l31787%2F Conclusion  Gastric adenocarcinoma of the intestinal type is less common in women with high endogenous estrogen exposure, indicating a preventive effect of estrogen. No differences in the distribution of ERs was found between the three estrogen exposure groups. The presence of ERbeta cx in gastric cancer warrants further investigation. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-008-0475-6Authors Evangelos Chandanos, Karolinska Institutet Unit of Esophageal and Gastric Research (ESOGAR), Section of Surgery, Department of Molecular Medicine and Surgery Stockholm SwedenCarlos A. Rubio, Karolinska University Hospital Department of Pathology Stockholm SwedenMats Lindblad, Karolinska Institutet Unit of Esophageal and Gastric Research (ESOGAR), Se... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1844002 Tue, 30 Sep 2008 09:20:47 +0100 1844002 http://www.medworm.com/index.php?rid=1844001&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw622015333t55260%2F Conclusion  From the point of view of curability, laparoscopic operation is an oncologically safe procedure for the management of gastric cancer, at least for stage I and II disease. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-008-0478-3Authors Xiaoqiao Zhang, Osaka Medical College Department of General and Gastroenterological Surgery 2-7, Daigaku-machi, Takatsuki Osaka 569-8686 JapanNobuhiko Tanigawa, Osaka Medical College Department of General and Gastroenterological Surgery 2-7, Daigaku-machi, Takatsuki Osaka 569-8686 JapanEiji Nomura, Osaka Medical College Department of General and Gastroenterological Surgery 2-7, Daigaku-machi, Takatsuki Osaka 569-8686 JapanSang-Woong Lee, Osaka Medical College Department of General and Gastroenterologic... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1844001 Tue, 30 Sep 2008 09:20:47 +0100 1844001 http://www.medworm.com/index.php?rid=1844005&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu80j1278r402w546%2F Abstract  Accurate prediction of lymph node (LN) status is of crucial importance for appropriate treatment planning in patients with early gastric cancer (EGC). However, there is no definitive consensus yet on which patient and/or tumor characteristics are associated with LN metastasis. A systematic search for studies investigating the relationship between patient and/or tumor characteristics and LN metastasis in EGC was performed in PubMed/MEDLINE. Patient and/or tumor characteristics associated with LN metastasis were identified by meta-analyzing results of individual studies. Forty-five studies were included. Variables significantly associated with LN metastasis in gastric cancer limited to the mucosa were: age younger than 57 years, tumor location in the middle part of ... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1844005 Tue, 30 Sep 2008 09:20:46 +0100 1844005 http://www.medworm.com/index.php?rid=1844004&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc536970jp2234535%2F Conclusion  Biological markers of cellular adhesion and gastric differentiation were differently expressed in young and older patients. Our findings support the hypothesis that young patients develop carcinomas with a different genetic pathway compared to the pathway of tumors occurring at a later age, and we suggest further investigations to assess the prognostic relevance of the markers to specific subgroups. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-008-0468-5Authors Edaise M. Silva, Hospital AC Camargo Department of Anatomic Pathology Rua Antonio Prudente, 109 - 1° Andar São Paulo 01509-010 BrazilMaria D. Begnami, Hospital AC Camargo Department of Anatomic Pathology Rua Antonio Prudente, 109 - 1° Andar São Paulo 01509-010 BrazilJo... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1844004 Tue, 30 Sep 2008 09:20:46 +0100 1844004 http://www.medworm.com/index.php?rid=1844003&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F53682533207225qq%2F Conclusion  These results strongly suggested that the presence of ECI or FF could affect the survival of patients with gastric cancer. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-008-0473-8Authors Takahide Okamoto, Shonan Tobu Sogou Hospital Department of Surgery 500 Nishikubo Chigasaki 253-0083 JapanAkira Tsuburaya, Kanagawa Cancer Center Department of Gastrointestinal Surgery Yokohama JapanYoichi Kameda, Kanagawa Cancer Center Department of Pathology Yokohama JapanTakaki Yoshikawa, Kanagawa Cancer Center Department of Gastrointestinal Surgery Yokohama JapanHaruhiko Cho, Kanagawa Cancer Center Department of Gastrointestinal Surgery Yokohama JapanKazuhito Tsuchida, Kanagawa Cancer Center Department of Gastrointestinal Surgery Yokohama JapanShi... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1844003 Tue, 30 Sep 2008 09:20:46 +0100 1844003 http://www.medworm.com/index.php?rid=1844007&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft0063752x5636370%2F Abstract  The use of laparoscopy-assisted distal gastrectomy has been gradually spreading and it has become one of the standard treatment options for early gastric cancer in Japan. But anastomotic problems are still frequent with this procedure, because of its technical difficulty. We have developed a simple, safe, and speedy Roux-en-Y anastomosis for use in laparoscopy-assisted distal gastrectomy. Here, we describe our technique and the short-term results. Content Type Journal ArticleCategory Technical NoteDOI 10.1007/s10120-008-0474-7Authors Eiichiro Toyama, Kumamoto University Department of Gastrointestinal Surgery, Graduate School of Medical Sciences 1-1-1 Honjyo Kumamoto 860-8556 JapanShinobu Honda, Kumamoto University Department of Gastrointestinal Surgery, Graduate... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1844007 Tue, 30 Sep 2008 09:20:45 +0100 1844007 http://www.medworm.com/index.php?rid=1844006&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb071um0v167n547v%2F Content Type Journal ArticleCategory EditorialDOI 10.1007/s10120-008-0479-2Authors Alexander R. Novotny, Technische Universität München Department of Surgery Ismaninger Str. 22 81675 Munich GermanyChristoph Schuhmacher, Technische Universität München Department of Surgery Ismaninger Str. 22 81675 Munich Germany Journal Gastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal Volume Volume 11 Journal Issue Volume 11, Number 3 / September, 2008 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1844006 Tue, 30 Sep 2008 09:20:45 +0100 1844006 http://www.medworm.com/index.php?rid=1574937&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6726q220l556k4v0%2F Abstract  An error occurred in the first sentence of the final paragraph in the section Statistical analyses on page 24. The sentence should read as follows: We used The Cochrane Collaboration software RevMan 4.2 to analyze the extracted data with both fixed-effect and random-effect model analysis [25]. Content Type Journal ArticleCategory ErratumDOI 10.1007/s10120-008-0470-yAuthors Jong-Myon Bae, Cheju National University College of Medicine Department of Preventive Medicine No. 1 Ara-1-dong, Jeju Jejudo 690-756 KoreaEun Ja Lee, Myongji Hospital, Kwandong University, College of Medicine Department of Radiology Koyang KoreaGordon Guyatt, McMaster University CLARITY Research Group, Department of Clinical Epidemiology & Biostatistics, Health Sciences Centre Hamilton On... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1574937 Wed, 02 Jul 2008 15:35:32 +0100 1574937 http://www.medworm.com/index.php?rid=1574936&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe1831p2560501371%2F Conclusion  Clinical pathways may reduce hospital stay and costs for patients undergoing gastrectomy for the treatment of gastric cancer. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-008-0458-7Authors Jimmy B. Y. So, National University Hospital, Yong Loo Lin School of Medicine, National University of Singapore Department of Surgery Lower Kent Ridge Road 119072 Singapore SingaporeZiliang L. Lim, National University Hospital, Yong Loo Lin School of Medicine, National University of Singapore Department of Surgery Lower Kent Ridge Road 119072 Singapore SingaporeHeng-An Lin, National University Hospital, Yong Loo Lin School of Medicine, National University of Singapore Department of Surgery Lower Kent Ridge Road 119072 Singapore SingaporeThiow-Kong... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1574936 Wed, 02 Jul 2008 15:35:32 +0100 1574936 http://www.medworm.com/index.php?rid=1574940&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd57vj37310rq7mwu%2F Conclusion  The site of the reservoir does not significantly influence the outcome after total gastrectomy and reconstruction with a preserved duodenal passage. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-008-0455-xAuthors Katalin Kalmár, University of Pécs Department of Surgery 13 Ifjuság str. 7624 Pécs HungaryZsolt Káposztás, University of Pécs Department of Surgery 13 Ifjuság str. 7624 Pécs HungaryGábor Varga, University of Pécs Department of Surgery 13 Ifjuság str. 7624 Pécs HungaryLászló Cseke, University of Pécs Department of Surgery 13 Ifjuság str. 7624 Pécs HungaryAndrás Papp, University of Pécs Department of Surgery 13 Ifjuság str. 7624 Pécs HungaryÖrs Péter Horváth, University of Pécs Department of Surgery ... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1574940 Wed, 02 Jul 2008 15:35:31 +0100 1574940 http://www.medworm.com/index.php?rid=1574939&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fmv7t57788137g106%2F Conclusion  GC has different associations with adipose tissue volume according to its histological type. As compared with differentiated GC, lower adipose tissue volume may be a preferential environment for the development and progression of undifferentiated GC. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-008-0459-6Authors Kensuke Otani, The University of Tokyo Department of Surgical Oncology 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8655 JapanJoji Kitayama, The University of Tokyo Department of Surgical Oncology 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8655 JapanShoichi Kaisaki, The University of Tokyo Department of Surgical Oncology 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8655 JapanHironori Ishigami, The University of Tokyo Department of Surgical Oncology 7-3-1 H... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1574939 Wed, 02 Jul 2008 15:35:31 +0100 1574939 http://www.medworm.com/index.php?rid=1574938&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw01u161453177172%2F Conclusion  Our findings revealed that invasion into the MP has an earlier propensity than expected, and a novel staging system taking this into account may provide a better stratification of prognosis than the current systems. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-008-0466-7Authors Keishi Yamashita, Kitasato University Hospital Department of Surgery 1-15-1 Kitastato, Sagamihara Kanagawa 228-8555 JapanShinichi Sakuramoto, Kitasato University Hospital Department of Surgery 1-15-1 Kitastato, Sagamihara Kanagawa 228-8555 JapanShiroh Kikuchi, Kitasato University Hospital Department of Surgery 1-15-1 Kitastato, Sagamihara Kanagawa 228-8555 JapanNatsuya Katada, Kitasato University Hospital Department of Surgery 1-15-1 Kitastato, Sagamihara Ka... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1574938 Wed, 02 Jul 2008 15:35:31 +0100 1574938 http://www.medworm.com/index.php?rid=1574941&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F516u065p03405081%2F Conclusion  We provide evidence suggesting a mechanism for the secretion of estrogen through the conversion of a precursor androgen in tumoral and nontumoral tissues in the stomach. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-008-0463-xAuthors Masao Izawa, Tottori University Division of Biosignaling, Department of Biomedical Science, School of Life Science, Faculty of Medicine 86 Nishi-machi Yonago 683-8503 JapanMasashi Inoue, Tottori University Department of Surgery, Faculty of Medicine Yonago JapanMitsuhiko Osaki, Tottori University Department of Pathology, Faculty of Medicine Yonago JapanHisao Ito, Tottori University Department of Pathology, Faculty of Medicine Yonago JapanTasuku Harada, Tottori University Department of Obstetrics and Gyne... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1574941 Wed, 02 Jul 2008 15:35:30 +0100 1574941 http://www.medworm.com/index.php?rid=1574943&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl456882k98842330%2F Content Type Journal ArticleCategory EditorialDOI 10.1007/s10120-008-0469-4Authors Yasuhiro Kodera, Nagoya University Graduate School of Medicine Department of Surgery II 65 Tsurumai-cho, Showa-ku, Nagoya Aichi 466-8550 Japan Journal Gastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal Volume Volume 11 Journal Issue Volume 11, Number 2 / June, 2008 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1574943 Wed, 02 Jul 2008 15:35:28 +0100 1574943 http://www.medworm.com/index.php?rid=1574942&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv253741873388l11%2F Conclusion  Our results show that D2 lymphadenectomy can be performed with low morbidity-mortality, and a 5-year survival of more than 50%. The procedure offers benefit in terms of survival for a certain percentage of patients with positive level N2 lymph nodes. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-008-0460-0Authors Álvaro Díaz De Liaño, Hospital Virgen del Camino Esophagogastric Unit, General and Digestive Surgery Department c/o Pintor Maeztu 2, 8C 31008 Pamplona, Navarra SpainConcepción Yarnoz, Hospital Virgen del Camino Esophagogastric Unit, General and Digestive Surgery Department c/o Pintor Maeztu 2, 8C 31008 Pamplona, Navarra SpainRubén Aguilar, Hospital Central Instituto de Previsión Social General Surgery Department Asunc... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1574942 Wed, 02 Jul 2008 15:35:28 +0100 1574942 http://www.medworm.com/index.php?rid=1574945&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc1731317840v0l25%2F Abstract  Esophageal squamous cell carcinoma is often accompanied by intramural metastases, and it has been reported to carry a poor prognosis. Intramural metastasis from gastric cancer to the esophageal wall, however, has rarely been reported. We herein report a rare case of a 46-year-old man with an elevated esophageal lesion, resembling a 0-IIa-type esophageal cancer, which was discovered 13 months after a total gastrectomy performed for gastric cancer. The esophageal tumor, resected by endoscopic mucosal resection (EMR), was an adenocarcinoma with the same histology as the previously resected primary gastric cancer, and it showed massive lymphatic permeation. Soon after the EMR, other similar lesions emerged on the esophageal wall. We therefore considered the esophageal... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1574945 Wed, 02 Jul 2008 15:35:26 +0100 1574945 http://www.medworm.com/index.php?rid=1574944&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F435852730u71267n%2F Content Type Journal ArticleCategory EditorialDOI 10.1007/s10120-008-0471-xAuthors Peter Gunvén, Karolinska University Hospital Department of Oncology SE 171 76 Stockholm Sweden Journal Gastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal Volume Volume 11 Journal Issue Volume 11, Number 2 / June, 2008 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1574944 Wed, 02 Jul 2008 15:35:26 +0100 1574944 http://www.medworm.com/index.php?rid=1574947&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fkx77158g16450u57%2F Content Type Journal ArticleCategory AnnouncementDOI 10.1007/s10120-008-0477-4 Journal Gastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal Volume Volume 11 Journal Issue Volume 11, Number 2 / June, 2008 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1574947 Wed, 02 Jul 2008 15:35:25 +0100 1574947 http://www.medworm.com/index.php?rid=1574946&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu86506630250k367%2F We describe a 30-year-old man in whom upper endoscopy revealed multiple gastric carcinoids. The peripheral blood gastrin level was 2400 ng/ml (normal range, <200 ng/ml). Mucosal biopsy of the gastric body and fundus showed no atrophy; typical type A chronic atrophic gastritis was thus unlikely. Neither abdominal computed tomography nor selective angiography showed any evidence of tumor in the pancreas or at its periphery. However, the possibility of microgastrinoma could not be ruled out. We performed radioguided surgery with a somatostatin analog, diethylenetriamine pentaacetic acid-D-Phe1-octreotide labeled with 111In (Octreo Scan). The location of the carcinoids was confirmed. Gastrinoma was ruled out. Total gastrectomy was performed, and the gastrin level decreased to the norma... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1574946 Wed, 02 Jul 2008 15:35:25 +0100 1574946 http://www.medworm.com/index.php?rid=1339832&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fev13277p87013651%2F Conclusion  Resectability and complication rates were similar in the two groups. However, operating time was shorter with IT-2, irrespective of the indications for the performance of ESD. This study suggests benefits of the IT-2 over the IT-OM. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-008-0452-0Authors Hiroyuki Ono, Shizuoka Cancer Center Hospital Division of Endoscopy and GI Oncology 1007 Shimonagakubo, Nagaizumi-cho Shizuoka 411-8777 JapanNoriaki Hasuike, Shizuoka Cancer Center Hospital Division of Endoscopy and GI Oncology 1007 Shimonagakubo, Nagaizumi-cho Shizuoka 411-8777 JapanTetsuya Inui, Shizuoka Cancer Center Hospital Division of Endoscopy and GI Oncology 1007 Shimonagakubo, Nagaizumi-cho Shizuoka 411-8777 JapanKohei Takizawa, Shi... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1339832 Sat, 29 Mar 2008 08:59:23 +0100 1339832 http://www.medworm.com/index.php?rid=1339834&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw50mm18g0l3hl441%2F Conclusion  Surgery for recurrent gastric cancer is a valid alternative in selected patients, provided it is performed by specialized work teams. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-007-0444-5Authors Álvaro Díaz De Liaño, Hospital Virgen del Camino Esophagogastric Unit, Department of General and Gastrointestinal Surgery C/ Pintor Maeztu 2, 8 °C Pamplona 31008 Navarra SpainConcepción Yarnoz, Hospital Virgen del Camino Esophagogastric Unit, Department of General and Gastrointestinal Surgery C/ Pintor Maeztu 2, 8 °C Pamplona 31008 Navarra SpainRubén Aguilar, Hospital Central Instituto de Previsión Social Department of General Surgery Asunción ParaguayCristina Artieda, Hospital Virgen del Camino Esophagogastric Unit, Department o... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1339834 Sat, 29 Mar 2008 08:59:21 +0100 1339834 http://www.medworm.com/index.php?rid=1339833&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F618158022863j838%2F Conclusion  Chromoendoscopy with hematoxylin increases opportunities for precision biopsy. The grade of endoscopic stained mucosa depends on epithelial cell proliferation and is associated with malignancy. By using histology as the main outcome, the sensitivity and specificity of chromoendoscopy with hematoxylin for diffuse staining in the detection of gastric neoplasia and adenocarcinoma were 92.9% and 89.3%, respectively. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-007-0445-4Authors Serguei Mouzyka, Hospital “LISSOD” Malyshko Street 27 Plyuty, Kiev 08720 UkraineAlexandra Fedoseeva, Hospital “LISSOD” Malyshko Street 27 Plyuty, Kiev 08720 Ukraine Journal Gastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal Volu... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1339833 Sat, 29 Mar 2008 08:59:21 +0100 1339833 http://www.medworm.com/index.php?rid=1339835&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm590360621404vl2%2F Abstract  Perioperative chemotherapy in stage II and stage III gastric cancer is now accepted as a standard of care in the Western world. Two randomized phase III studies have shown improved survival for patients with induction chemotherapy followed by surgery compared with surgery alone. It is generally accepted that patients who respond to induction therapy have a significantly improved survival compared with that in nonresponding patients. Unfortunately no prospectively tested markers predicting response and/or prognosis are available for clinical practice. In adenocarcinomas of the esophagogastric junction (AEG), fluorodeoxyglucose-positron emission tomography (FDG-PET) prospectively was established as a surrogate predicting response and prognosis. The MUNICON (Metaboli... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1339835 Sat, 29 Mar 2008 08:59:20 +0100 1339835 http://www.medworm.com/index.php?rid=1339838&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv541101h14331717%2F Conclusion  Pooled results from observational studies support a protective effect of high citrus fruit intake in the risk of stomach cancer. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-007-0447-2Authors Jong-Myon Bae, Cheju National University College of Medicine Department of Preventive Medicine No. 1 Ara-1-dong Jeju, Jejudo 690-756 KoreaEun Ja Lee, Myongji Hospital, Kwandong University, College of Medicine Department of Radiology Koyang KoreaGordon Guyatt, McMaster University CLARITY Research Group, Department of Clinical Epidemiology & Biostatistics, Health Sciences Centre Hamilton Ontario Canada Journal Gastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal Volume Volume 11 Journal Issue Volume 11, Number 1 / March,... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1339838 Sat, 29 Mar 2008 08:59:19 +0100 1339838 http://www.medworm.com/index.php?rid=1339837&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd5m3403048h1t415%2F We report a case of suture-line recurrence at a jejunojejunal anastomosis without recurrence at the gastrojejunal anastomosis or in the remnant stomach in a patient 23 months after receiving a Billroth II gastrectomy for gastric cancer. We attributed the implantation of cancer cells at the jejunojejunal anastomosis to contamination of the stapler with cancer cells exfoliated in the gastric mucus during the construction of the gastrojejunal anastomosis. We therefore consider that different surgical instruments, such as automatic anastomotic devices and automatic suturing devices, must be used in each phase of the surgical procedure for gastric cancer. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10120-007-0446-3Authors Alexandros Polychronidis, Democritus Universit... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1339837 Sat, 29 Mar 2008 08:59:19 +0100 1339837 http://www.medworm.com/index.php?rid=1339836&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F550218270465m667%2F Conclusion  Smaller pouches never achieve adequate volumes at basal pressures; accordingly, it is unlikely that they will lead to any clinical benefit. Further in-vivo studies should therefore be based upon 15-cm pouch designs. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-007-0450-7Authors Shayanthan Nanthakumaran, Grampian University Hospital Trust Department of Upper Gastrointestinal Surgery, Aberdeen Royal Infirmary Aberdeen AB25 2ZD UKStuart A. Suttie, Grampian University Hospital Trust Department of Upper Gastrointestinal Surgery, Aberdeen Royal Infirmary Aberdeen AB25 2ZD UKHoward W. Chandler, University of Aberdeen School of Engineering and Physical Sciences Aberdeen UKKenneth G. M. Park, Grampian University Hospital Trust Department of... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1339836 Sat, 29 Mar 2008 08:59:19 +0100 1339836 http://www.medworm.com/index.php?rid=1339839&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl5r05g7270k825t1%2F Conclusion  Our data suggest that MCM2 is a useful prognostic marker in patients stage III diffuse-type gastric carcinoma. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-008-0451-1Authors Naruo Tokuyasu, Tottori University Division of Organ Pathology, Department of Microbiology and Pathology, Faculty of Medicine 86 Nishi-cho, Yonago Tottori 683-8503 JapanKohei Shomori, Tottori University Division of Organ Pathology, Department of Microbiology and Pathology, Faculty of Medicine 86 Nishi-cho, Yonago Tottori 683-8503 JapanKeisuke Nishihara, Tottori University Division of Organ Pathology, Department of Microbiology and Pathology, Faculty of Medicine 86 Nishi-cho, Yonago Tottori 683-8503 JapanHiroki Kawaguchi, Yonago Medical Center Hospital Division o... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1339839 Sat, 29 Mar 2008 08:59:18 +0100 1339839 http://www.medworm.com/index.php?rid=1339840&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fcx4m551350957106%2F We report two cases of node-positive differentiated sm1 gastric cancer without lymphatic invasion into the submucosal layer. Case 1 was a 73-year-old man who underwent EMR for 0-IIc early gastric cancer (EGC) on the gastric angle, with a histological diagnosis of tub1. Pathological examination revealed a 0-IIc lesion that was 12 mm in size and sm1 in invasion depth without lymphatic-vascular invasion. However, the infiltration in the submucosal layer was relatively wide. The patient subsequently underwent distal gastrectomy with D2 lymph node dissection. Pathological examination revealed level 2 lymph node metastasis. Case 2 was a 62-year-old woman who underwent ER for a 0-I+IIc-type EGC on the greater curvature of the antrum, with a histological diagnosis of tub1. Pathological exami... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1339840 Sat, 29 Mar 2008 08:59:16 +0100 1339840 http://www.medworm.com/index.php?rid=1339841&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F416g067g44132475%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s10120-008-0454-yAuthors Jolie Ringash, The Princess Margaret Hospital 610 University Ave. Toronto ON M5G 2M9 CanadaStephen R. Smalley, Olathe Regional Oncology Center Olathe KS USALeonard L. Gunderson, Mayo Clinic Cancer Center — Arizona Scottsdale AZ USA Journal Gastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal Volume Volume 11 Journal Issue Volume 11, Number 1 / March, 2008 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1339841 Sat, 29 Mar 2008 08:59:15 +0100 1339841 http://www.medworm.com/index.php?rid=1111208&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff844282380484651%2F Conclusion  The patients showed a decrease of 25(OH) vitamin D3 and 24,25(OH)2 vitamin D3, which are metabolites that show weak activity. This suggests that a homeostatic response maintains the normal level of 1,25(OH)2 vitamin D3, which is important for calcium regulation. Thus, it was suggested that gastrectomy had a moderate influence on the metabolism of vitamin D. However we could not detect any factor associated with the decrease of 25(OH) vitamin D3 and 24,25(OH)2 vitamin D3. Content Type Journal ArticleCategory Original articleDOI 10.1007/s10120-007-0439-2Authors Yasushi Rino, Yokohama City University School of Medicine Department of Surgery 3-9 Fukuura, Kanazawa-ku Yokohama 236-0004 JapanYuji Yamamoto, Kanagawa Prefectural Ashigara-kami Hospital Department of... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1111208 Thu, 20 Dec 2007 16:26:30 +0100 1111208 http://www.medworm.com/index.php?rid=1111215&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm3t0q68022581478%2F Conclusion  Conventional pathological factors, such as tumor size, depth of submucosal invasion, and lymphatic invasion, have a significant influence on lymph node metastasis. VEGF expression and DC expression may be helpful predictors of lymph node metastasis in patients with sm1 and sm3 gastric cancer, respectively. Content Type Journal ArticleCategory Original articleDOI 10.1007/s10120-007-0442-7Authors Shinji Ohashi, Toyohashi Municipal Hospital Center for Preventive Medicine 50 Aotake-cho Toyohashi 441-8085 JapanShozo Okamura, Toyohashi Municipal Hospital Department of Gastroenterology Toyohashi JapanFumihiro Urano, Toyohashi Municipal Hospital Department of Gastroenterology Toyohashi JapanMatsuyoshi Maeda, Toyohashi Municipal Hospital Department of Pathology Toyo... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1111215 Thu, 20 Dec 2007 16:26:29 +0100 1111215 http://www.medworm.com/index.php?rid=1111214&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe4775855j7289775%2F Conclusion  The early metabolic response evaluated by 18F-FDG-PET predicted the clinical outcome in this series of patients with advanced gastric cancer treated with chemotherapy plus cetuximab. Content Type Journal ArticleCategory Original articleDOI 10.1007/s10120-007-0438-3Authors Francesca Di Fabio, S. Orsola-Malpighi Hospital Medical Oncology Unit Via Albertoni 15-40138 Bologna ItalyCarmine Pinto, S. Orsola-Malpighi Hospital Medical Oncology Unit Via Albertoni 15-40138 Bologna ItalyFabiola L. Rojas Llimpe, S. Orsola-Malpighi Hospital Medical Oncology Unit Via Albertoni 15-40138 Bologna ItalyStefano Fanti, S. Orsola-Malpighi Hospital Nuclear Medicine Unit Bologna ItalyPaolo Castellucci, S. Orsola-Malpighi Hospital Nuclear Medicine Unit Bologna ItalyCiro Longobardi, ... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1111214 Thu, 20 Dec 2007 16:26:29 +0100 1111214 http://www.medworm.com/index.php?rid=1111213&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6357462725430510%2F Conclusion  The majority of surgeons operating on gastric cancer in Ontario did not identify recommended quality indicators of gastric cancer surgery. A continuing medical education program should be designed to address this knowledge gap to improve the quality of surgery and patient outcomes. Content Type Journal ArticleCategory Original articleDOI 10.1007/s10120-007-0435-6Authors Lucy K. Helyer, University Health Network Department of Surgical Oncology, Princess Margaret Hospital 610 University Avenue Toronto Ontario M5G 2M9 CanadaCatherine O'Brien, University Health Network Department of Surgical Oncology, Princess Margaret Hospital 610 University Avenue Toronto Ontario M5G 2M9 CanadaNatalie G. Coburn, Sunnybrook Health Sciences Division of Surgical Oncology Toronto... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1111213 Thu, 20 Dec 2007 16:26:29 +0100 1111213 http://www.medworm.com/index.php?rid=1111212&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F718344150626718k%2F Conclusion  These results suggest that the OPRT level is significantly higher in gastric carcinoma tissue than in normal gastric mucosa and that the OPRT level in gastric carcinoma is a novel variable that is independent of the levels of other previously known enzymes related to 5-fluorouracil (FU) metabolism. Content Type Journal ArticleCategory Original articleDOI 10.1007/s10120-007-0440-9Authors Yoichi Sakurai, Fujita Health University School of Medicine Department of Surgery 1-98 Dengakugakubo Kutsukake-cho Toyoake 470-1192 JapanShingo Kamoshida, Fujita Health University School of Medicine Department of Pathology Toyoake JapanShinpei Furuta, Fujita Health University School of Medicine Department of Surgery 1-98 Dengakugakubo Kutsukake-cho Toyoake 470-1192 JapanRisa... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1111212 Thu, 20 Dec 2007 16:26:29 +0100 1111212 http://www.medworm.com/index.php?rid=1111211&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fwh5030436g427w36%2F We report a patient with type 3 gastric cancer with peritoneal dissemination and hydronephrosis who was successfully treated with intraperitoneal infusion of paclitaxel and oral administration of S-1. He was diagnosed with unresectable gastric cancer with severe peritoneal dissemination by staging laparoscopy. We selected combined chemotherapy with both paclitaxel and S-1. Paclitaxel at 60 mg/m2 was administered intraperitoneally on days 1 and 8, and S-1 at 100 mg/body was administered orally for 14 days, followed by 7 days’ rest, as one course. After five courses, primary tumor reduction was confirmed and no cancer cells were detected on pathocytological investigation at second-look laparoscopy. The patient underwent total gastrectomy with lymph node dissection. He died from l... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1111211 Thu, 20 Dec 2007 16:26:29 +0100 1111211 http://www.medworm.com/index.php?rid=1111210&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd5472288h54825q5%2F Conclusion  R1 resections and gastrojejunostomy were associated with low surgical morbidity and mortality, unlike R2 resection; in this group, surgical morbidity and mortality was high. Therefore, the benefit of palliative resection in the presence of extensive residual disease should be balanced against the risk of surgical morbidity. Content Type Journal ArticleCategory Original articleDOI 10.1007/s10120-007-0437-4Authors Luis F. Oñate-Ocaña, Instituto Nacional de Cancerología Clinica de Neoplasias Gástricas, Departamento de Gastroenterología San Fernando 22, Colonia Sección XVI, Tlalpan, D.F. 14080 Mexico City MexicoGuadalupe Méndez-Cruz, Instituto Nacional de Cancerología Clinica de Neoplasias Gástricas, Departamento de Gastroenterología San Fernando 22, ... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1111210 Thu, 20 Dec 2007 16:26:29 +0100 1111210 http://www.medworm.com/index.php?rid=1111209&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn330120284k097l2%2F Abstract  The purpose of this review is to examine the current status and future perspectives of the molecular analysis of peritoneal lavage fluid in patients with gastric cancer. During the past 10 years, the polymerase chain reaction (PCR) has been applied for the molecular detection of free cancer cells in the abdominal cavity of patients with gastric cancer, and its clinical significance in establishing the presence of peritoneal dissemination has been assessed by several groups especially in Japan. The majority of these studies have confirmed the predictive value of the molecular detection of peritoneal metastasis and recurrence using peritoneal lavage fluid. Based on these findings, since April 2006, the genetic diagnosis of body fluids has been included in the Japane... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1111209 Thu, 20 Dec 2007 16:26:29 +0100 1111209 http://www.medworm.com/index.php?rid=1111207&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx8h3152812j2g56t%2F Abstract  We herein present a case of recurrence of gastric cancer in the jejunal pouch after total gastrectomy in a 74-year-old man. He had a history of two operations for gastric cancer. The second operation was a completion gastrectomy with jejunal pouch reconstruction and regional lymphadenectomy, for gastric cancer in the cardia of the remnant stomach, performed 2 years and 9 months before the present admission. A follow-up endoscopy showed three elevated tumors along the suture lines in the jejunal pouch in the upper digestive tract. Resection of the jejunal pouch was performed. Gross pathological examination revealed elevated lesions along the staple suture lines in the jejunal pouch. Histopathologically, moderately differentiated tubular adenocarcinoma involving the... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=1111207 Thu, 20 Dec 2007 16:26:29 +0100 1111207 http://www.medworm.com/index.php?rid=938445&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn486628387u12101%2F We report this case because of its importance regarding the need to carry out close surveillance in transplant recipients who are treated with immunosuppressive drugs, in order to make a timely identification of the occurrence of common malignancies. Content Type Journal ArticleCategory Case reportDOI 10.1007/s10120-007-0428-5Authors Yasuhiro Nagata, Nagasaki University Graduate School of Biomedical Sciences Department of Surgery Nagasaki JapanSusumu Eguchi, Nagasaki University Graduate School of Biomedical Sciences Department of Surgery Nagasaki JapanMitsuhisa Takatsuki, Nagasaki University Graduate School of Biomedical Sciences Department of Surgery Nagasaki JapanAkihito Enjoji, Nagasaki University Graduate School of Biomedical Sciences Department of Surgery Nagasaki JapanTatsuki ... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=938445 Sat, 06 Oct 2007 17:45:41 +0100 938445 http://www.medworm.com/index.php?rid=938444&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fxr8102433q22n838%2F Abstract  Laparoscopic surgery is increasingly being applied to gastric cancer surgery, including proximal gastrectomy for the resection of cancer located in the upper gastric body. Despite the ease of use of stapling devices for end-to-end anastomosis, esophagogastric anastomosis is complicated by the narrow laparoscopic space, making the placement of an esophageal purse-string suture and anvil insertion into the fragile and contracted esophagus difficult. The aim of this study was to employ a novel esophagogastric anastomosis technique for laparoscopic surgery which may avoid esophageal breakdown. Eleven patients with early gastric cancer within the upper gastric body underwent laparoscopic proximal gastrectomy. The anvil of the stapler was introduced into the esophagus t... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=938444 Sat, 06 Oct 2007 17:45:41 +0100 938444 http://www.medworm.com/index.php?rid=938441&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Feh3671v13866815j%2F Abstract  A 63-year-old woman with appetite loss and general fatigue underwent gastrointestinal fiberscopy, which revealed type 2 advanced gastric cancer. Multidetector-row computed tomography revealed a massive gastric cancer invading the left hepatic lobe, pancreatic head, and common hepatic artery, as well as revealing a duplicated hepatic artery in which the right hepatic artery branched directly from the celiac axis, and ran behind the splenic vein. On the other hand, the common hepatic artery ran anterior to the splenic vein. We were able to perform pancreaticoduodenectomy with common hepatic artery resection and left lobectomy as curative surgery because her duplicated hepatic artery enabled us to ligate the common hepatic artery. Her postoperative clinical course wa... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=938441 Sat, 06 Oct 2007 17:45:41 +0100 938441 http://www.medworm.com/index.php?rid=938443&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm665172208360610%2F Conclusion  For gastric cancer patients who survive a period of time after diagnosis, the largest increases in conditional survival are seen for patients with advanced stage disease and for those less than 65 years old. Conditional survival can provide more relevant prognostic information than survival from the time of diagnosis for gastric cancer patients who survive a period of time after diagnosis. Content Type Journal ArticleCategory Original articleDOI 10.1007/s10120-007-0424-9Authors Samuel J. Wang, MC KPV4, Oregon Health and Science University Department of Radiation Medicine 3181 SW Sam Jackson Park Road Portland OR 97239-3098 USARachel Emery, Oregon Health and Science University School of Medicine Portland OR USAClifton D. Fuller, University of Texas Health S... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=938443 Sat, 06 Oct 2007 17:45:40 +0100 938443 http://www.medworm.com/index.php?rid=938440&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw0130u54211656j1%2F Abstract  The aim of this study was to evaluate the family history of cancer in Japanese gastric cancer patients and to investigate the clinicopathological features of gastric cancer patients with and without a family history of cancer. Four hundred and forty gastric cancer patients were enrolled in this study. The family history (first- and second-degree relatives) was investigated. The 440 patients were divided into three groups: (1) patients with a family history of gastric cancer; (2) patients with a family history of other cancers; and (3) patients without a family history of cancer. Two hundred and four patients (46.4%) reported a family history of cancer. Gastric cancer was the most frequent, with 98 patients having a total of 123 reports of gastric cancer in the fam... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=938440 Sat, 06 Oct 2007 17:45:40 +0100 938440 http://www.medworm.com/index.php?rid=938439&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6202361504u5p3h8%2F Conclusion  Patients with advanced GIST exhibiting focal disease progression during imatinib therapy may benefit from surgical resection and imatinib continuation. Imatinib resistance seems to be partial in these patients. Content Type Journal ArticleCategory Original articleDOI 10.1007/s10120-007-0425-8Authors Salah-Eddin Al-Batran, Krankenhaus Nordwest Department of Hematology and Oncology Steinbacher Hohl 2-26 60488 Frankfurt am Main GermanyJoerg Thomas Hartmann, Eberhard-Karls-University Department of Medical Oncology, Hematology, Immunology, Rheumatology and Pulmology, South West Cancer Center Tuebingen GermanyFlorian Heidel, Johannes Gutenberg University Third Medical Department Mainz GermanyJan Stoehlmacher, University Hospital Eppendorf Department of Internal Me... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=938439 Sat, 06 Oct 2007 17:45:40 +0100 938439 http://www.medworm.com/index.php?rid=938438&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F55v88t21x444x3x8%2F Abstract  Although laparoscopic distal gastrectomy (LDG) has been accepted as a surgical option for the treatment of early gastric cancer, laparoscopic total gastrectomy (LTG) has been adopted less often, because a more difficult surgical technique is required for reconstruction. To reduce the technical difficulties, we made some modifications to the functional end-to-end anastomosis technique and performed esophagojejunal anastomosis through a minilaparotomy. First, for easier handling of the esophagus, the first application of the linear stapler to create the esophagojejunal anastomosis was performed before transection of the esophagus. Second, the jejunal limb was anastomosed to the left side of the esophagus, which, compared with the right side, made available more free... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=938438 Sat, 06 Oct 2007 17:45:40 +0100 938438 http://www.medworm.com/index.php?rid=938437&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd6157237gk883g44%2F Conclusion  The presence of GPT cells in patients with gastric adenocarcinoma is a significant and independent prognostic indicator. Content Type Journal ArticleCategory Original articleDOI 10.1007/s10120-007-0429-4Authors Michael R. Stephens, Royal Gwent Hospital Department of Surgery Newport UKAndrew N. Hopper, Royal Gwent Hospital Department of Surgery Newport UKWyn G. Lewis, Royal Gwent Hospital Department of Surgery Newport UKGuy Blackshaw, Royal Gwent Hospital Department of Surgery Newport UKPaul Edwards, University Hospital of Wales Department of Surgery Health Park Cardiff UKBecky Osborne, Royal Gwent Hospital Department of Pathology Newport UKIan W. Thompson, Royal Gwent Hospital Department of Pathology Newport UK Journal Gastric CancerOnline ISSN 1436-33... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=938437 Sat, 06 Oct 2007 17:45:40 +0100 938437 http://www.medworm.com/index.php?rid=938442&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv17132860q0t1189%2F Conclusion  The long-term results show that PPG has clear advantages over DGBI in terms of postoperative symptoms and functional outcomes. These results imply that PPG should be the recommended procedure for early gastric cancers located in the middle third of the stomach. Content Type Journal ArticleCategory Original articleDOI 10.1007/s10120-007-0434-7Authors Souya Nunobe, National Cancer Center Hospital Department of Surgery Tokyo 104-0045 JapanMitsuru Sasako, National Cancer Center Hospital Department of Surgery Tokyo 104-0045 JapanMakoto Saka, National Cancer Center Hospital Department of Surgery Tokyo 104-0045 JapanTakeo Fukagawa, National Cancer Center Hospital Department of Surgery Tokyo 104-0045 JapanHitosho Katai, National Cancer Center Hospital Department of... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=938442 Sat, 06 Oct 2007 17:45:39 +0100 938442 http://www.medworm.com/index.php?rid=681207&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg2h2w64184w67227%2F Conclusion  The study found that the expression of both p53 and MK-1 was frequent in aggressive gastric carcinomas; however, extensive lymph node involvement (more than five nodes) was the only significant factor related to overall survival. Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 10 Journal IssueVolume 10, Number 2 / June, 2007 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=681207 Tue, 19 Jun 2007 18:13:35 +0100 681207 http://www.medworm.com/index.php?rid=681206&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq064k1152556t741%2F Conclusion  For T1N0 gastric cancer, modified gastrectomy (D1+a dissection) combined with SNNS is suitable; however, for those whose Group 2 lymph nodes are judged to be SNs, additional dissection of lymphatic basins detected by SNNS should be performed to confirm the absence of lymph node metastasis. Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 10 Journal IssueVolume 10, Number 2 / June, 2007 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=681206 Tue, 19 Jun 2007 18:13:35 +0100 681206 http://www.medworm.com/index.php?rid=681205&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F973u668k23727355%2F Abstract  Based on more than 11 years of follow-up, autopsy-based analysis of recurrence in the Dutch D1-D2 Trial permits meaningful assessment of patterns of failure with respect to the Maruyama Index (MI). We previously reported that a low Maruyama Index was an independent predictor of both overall and disease-specific survival. Autopsy results are available for 441 deaths on study. Distant-only failure (15% vs 13%) was no different between the MI categories, but isolated “regional” failure (8% for MI < 5 group vs 21%) and “regional + distant” failure (19% for MI < 5 group vs 36%) occurred less frequently in the MI < 5 group (P < 0.001). We conclude that “low Maruyama Index” surgery enhances regional control and survival but does not alter the occur... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=681205 Tue, 19 Jun 2007 18:13:35 +0100 681205 http://www.medworm.com/index.php?rid=681204&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1h168079k0536030%2F In conclusion, dietary modification by reducing salt and salted food intake, as well as by increasing intake of fruit and vitamin C, represents a practical strategy to prevent gastric cancer. Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 10 Journal IssueVolume 10, Number 2 / June, 2007 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=681204 Tue, 19 Jun 2007 18:13:35 +0100 681204 http://www.medworm.com/index.php?rid=681200&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8457n55n50j6v013%2F Conclusion  Gastric cancer in patients younger than 40 years is closely associated with H. pylori infection, but not with genetic characteristics. Eradication therapy for H. pylori and endoscopic examination of H. pylori-positive young adults may be anticipated to be adopted as a strategy for the prevention and/or early detection of cancer. Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 10 Journal IssueVolume 10, Number 2 / June, 2007 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=681200 Tue, 19 Jun 2007 18:13:35 +0100 681200 http://www.medworm.com/index.php?rid=681197&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F08v3j27556707g07%2F Abstract  A 53-year-old Japanese woman with bilateral ovarian tumors consulted our department. Gastroendoscopy disclosed 16 superficial depressed gastric lesions, and the histopathological diagnosis of the biopsy specimens was poorly differentiated adenocarcinoma and signet-ring cell carcinoma. Computed tomography (CT), ultrasonography (US), and positron emission tomography (PET) examinations revealed no other metastasis except for that observed in the ovaries. We performed a total gastrectomy with radical lymph node dissection and bilateral ovarian resection. A postoperative histological examination revealed 43 isolated gastric lesions which were scattered over the entire resected stomach; they were all confined to the mucosa. Cancer cell invasion in the lymphatics was det... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=681197 Tue, 19 Jun 2007 18:13:35 +0100 681197 http://www.medworm.com/index.php?rid=681209&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp5426r1k01qg1676%2F Conclusion  Our data indicate that both the clinicopathological characteristics and the prognoses of patients with skip metastasis were similar to those of patients with N1 LN metastasis, but these features were not similar to those in patients with N2 LN metastasis. The sites of skip metastasis presented in the current study may be the key for applying the concept of the sentinel node in gastric cancer. Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 10 Journal IssueVolume 10, Number 2 / June, 2007 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=681209 Tue, 19 Jun 2007 18:13:34 +0100 681209 http://www.medworm.com/index.php?rid=681208&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F77272g25l382337k%2F Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 10 Journal IssueVolume 10, Number 2 / June, 2007 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=681208 Tue, 19 Jun 2007 18:13:34 +0100 681208 http://www.medworm.com/index.php?rid=681203&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff662447w261562q5%2F Conclusion  The combination of oxaliplatin and docetaxel shows only marginal activity as second-line treatment, but it has a good tolerability profile. This suggests that there is room for optimizing the schedule as well as for planning sequential treatments in gastric cancer. Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 10 Journal IssueVolume 10, Number 2 / June, 2007 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=681203 Tue, 19 Jun 2007 18:13:34 +0100 681203 http://www.medworm.com/index.php?rid=681201&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy33n3x3m4t451844%2F Conclusion  According to our results, adequate training in the Japanese surgical technique, progress along the learning curve for D2 lymphadenectomy, and the establishment of specialized units are highly recommended for the surgical treatment of gastric cancer in Western referral hospitals. Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 10 Journal IssueVolume 10, Number 2 / June, 2007 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=681201 Tue, 19 Jun 2007 18:13:34 +0100 681201 http://www.medworm.com/index.php?rid=681202&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe74045114x481160%2F Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 10 Journal IssueVolume 10, Number 2 / June, 2007 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=681202 Tue, 19 Jun 2007 18:13:33 +0100 681202 http://www.medworm.com/index.php?rid=681199&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx62g37mu1xt37114%2F Conclusion  The ET-A blockade by YM598 had a strong inhibitory effect against tumor growth and liver metastasis of the gastric cancer cell lines. These data suggest that YM598 has potential as a novel therapeutic agent for inhibiting liver metastasis of gastric cancer. Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 10 Journal IssueVolume 10, Number 2 / June, 2007 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=681199 Tue, 19 Jun 2007 18:13:33 +0100 681199 http://www.medworm.com/index.php?rid=681198&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn776371142r7316r%2F Conclusion  These findings identified possible risk factors for severe adverse events of S-1 and the patient subgroups at potentially higher risk from its administration. The results will facilitate safer administration of S-1 and thus promote enhanced tolerability and efficacy. Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 10 Journal IssueVolume 10, Number 2 / June, 2007 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=681198 Tue, 19 Jun 2007 18:13:33 +0100 681198 http://www.medworm.com/index.php?rid=467049&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8211745364741426%2F We report on the successful treatment of advanced gastric cancer by surgical resection following neoadjuvant chemotherapy. A 67-year-old man was referred to our hospital with a diagnosis of pancreatic cancer. Meticulous examination, however, revealed the presence of gastric cancer with ascites and large lymph node metastasis adjacent to the pancreas. We selected combination chemotherapy with oral S-1 and biweekly paclitaxel. After two courses, both the primary tumor and metastatic lymph nodes were greatly reduced, and the ascites had disappeared. Using laparoscopy, there was no evidence of peritoneal metastases, and the cytological examination was negative. The patient underwent distal gastrectomy with D2 lymph node dissection. Histological examination revealed that the cancer cells were s... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=467049 Mon, 05 Mar 2007 22:02:48 +0100 467049 http://www.medworm.com/index.php?rid=467048&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F00816q3543134k95%2F Conclusion??The weekly administration of paclitaxel, for which a single dose is about one-third of the dose for a tri-weekly treatment regimen, is clinically feasible and appropriate in terms of toxicity and the maintenance of an effective plasma concentration. Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 10 Journal IssueVolume 10, Number 1 / February, 2007 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=467048 Mon, 05 Mar 2007 22:02:48 +0100 467048 http://www.medworm.com/index.php?rid=467055&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ffmr7wn67u2572t27%2F Abstract??The purpose of this review is to examine recent advances in the techniques and technologies of endoscopic resection of early gastric cancer (EGC). Endoscopic mucosal resection (EMR) of EGC, with negligible risk of lymph node metastasis, is a standard technique in Japan and is increasingly becoming accepted and regularly used in Western countries. EMR is a minimally invasive technique which is safe, convenient, and efficacious; however, it is insufficient when treating larger lesions. The evidence suggests that difficulties with the correct assessment of depth of tumor invasion lead to an increase in local recurrence with standard EMR when lesions are larger than 15?mm. A major factor contributing to this increase in local recurrence relates to lesions being excised piecemeal due ... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=467055 Mon, 05 Mar 2007 22:02:47 +0100 467055 http://www.medworm.com/index.php?rid=467052&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp6pj3n6758k66024%2F Conclusion??Our results indicate that pAkt expression may be useful for predicting the prognosis and efficacy of fluorouracil treatment in patients with gastric cancer. Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 10 Journal IssueVolume 10, Number 1 / February, 2007 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=467052 Mon, 05 Mar 2007 22:02:47 +0100 467052 http://www.medworm.com/index.php?rid=467051&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy2qmp238705u874q%2F Conclusion??Due to improved perioperative management, resection of gastric carcinoma is the treatment of choice in elderly patients. Although comorbidities were more frequent among the elderly patients, postoperative morbidity and mortality, even after extensive resections, was low. Survival rates were comparable to those in the younger patients. Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 10 Journal IssueVolume 10, Number 1 / February, 2007 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=467051 Mon, 05 Mar 2007 22:02:47 +0100 467051 http://www.medworm.com/index.php?rid=467057&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx563847j5mg20q76%2F Conclusion??Staging laparoscopy with peritoneal lavage cytology is a safe, effective tool in patients with locally advanced gastric cancer, especially in patients receiving neoadjuvant chemotherapy. Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 10 Journal IssueVolume 10, Number 1 / February, 2007 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=467057 Mon, 05 Mar 2007 22:02:46 +0100 467057 http://www.medworm.com/index.php?rid=467053&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe18j141552730756%2F We report a case of gastric carcinosarcoma presenting as a large mass in the epigastric region. Specimens obtained by endoscopic biopsy and surgical excision showed diffuse proliferation of atypical cells in sheet formation. No mucus production or glandular structures were apparent, but immunoreactivity for both epithelial and mesenchymal markers was noted. These findings led to a definitive diagnosis of gastric carcinosarcoma. Immunohistochemical analysis is useful for the early diagnosis and treatment of gastric carcinosarcoma. Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 10 Journal IssueVolume 10, Number 1 / February, 2007 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=467053 Mon, 05 Mar 2007 22:02:46 +0100 467053 http://www.medworm.com/index.php?rid=467050&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn2h11h52616j7717%2F Conclusion??It is unlikely that viable cancer cells disseminated into the bursa remain restricted to this cavity without migrating into the free abdominal cavity. Routine bursectomy may not be an essential procedure for resecting gastric cancer, from the viewpoint of eliminating microscopic peritoneal deposits within the omental bursa. Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 10 Journal IssueVolume 10, Number 1 / February, 2007 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=467050 Mon, 05 Mar 2007 22:02:46 +0100 467050 http://www.medworm.com/index.php?rid=467047&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7061j1nh01xu8565%2F Conclusion??Three cases had lymph node metastases that met the extended criteria for EMR/ESD. EMR and/or ESD should be limited to M cancers without ulcer or differentiated-type M cancer with ulcers smaller than 2?cm. When the depth of tumor invasion is deeper than M, then a gastric resection with lymph node dissection is necessary. Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 10 Journal IssueVolume 10, Number 1 / February, 2007 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=467047 Mon, 05 Mar 2007 22:02:46 +0100 467047 http://www.medworm.com/index.php?rid=467056&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw5h75h04q94q7070%2F Conclusion??Our results support that VEGF and CD-105 are closely relevant to lymph node metastasis and act as two valuable indicators of prognosis. Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 10 Journal IssueVolume 10, Number 1 / February, 2007 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=467056 Mon, 05 Mar 2007 22:02:45 +0100 467056 http://www.medworm.com/index.php?rid=467054&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F605m1182v2114425%2F Conclusion??Gastric adenocarcinoma with positive PWC should be considered stage IV disease. PWC should be included in the staging of gastric adenocarcinoma. Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 10 Journal IssueVolume 10, Number 1 / February, 2007 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=467054 Mon, 05 Mar 2007 22:02:45 +0100 467054 http://www.medworm.com/index.php?rid=298743&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl45133163301m783%2F AbstractThis review contains a practical guide as well as a number of design and analytical methods for conducting health-related quality of life assessments in clinical trials for gastric cancer treatment. Although we address issues specific to the assessment of gastric cancer, many are applicable to clinical trials for different cancer types. Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 9 Journal IssueVolume 9, Number 4 / November, 2006 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=298743 Sat, 25 Nov 2006 08:18:15 +0100 298743 http://www.medworm.com/index.php?rid=298741&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4m147152w54511lw%2F ConclusionMost patients with EGC were detected outside of mass screening. This suggests that the Japanese public and physicians are well aware of the risk of gastric cancer and the importance of early detection. The effect of mass screening is misunderstood. Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 9 Journal IssueVolume 9, Number 4 / November, 2006 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=298741 Sat, 25 Nov 2006 08:18:15 +0100 298741 http://www.medworm.com/index.php?rid=298735&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc3q2n2x37710unq1%2F Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 9 Journal IssueVolume 9, Number 4 / November, 2006 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=298735 Sat, 25 Nov 2006 08:18:15 +0100 298735 http://www.medworm.com/index.php?rid=298747&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F32m2071423131861%2F ConclusionsFor LADG in patients with early gastric cancer, obesity may affect the operation time, and men with high BMI require a longer operation time than do women with normal or high BMI. Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 9 Journal IssueVolume 9, Number 4 / November, 2006 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=298747 Sat, 25 Nov 2006 08:18:14 +0100 298747 http://www.medworm.com/index.php?rid=298746&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fuk100472gr761388%2F ConclusionThe incidence of disseminated cancer cells in bone marrow in our study appears low, unlike that in previous reports. The significance of disseminated cancer cells in bone marrow may also be quite low in gastric cancer. Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 9 Journal IssueVolume 9, Number 4 / November, 2006 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=298746 Sat, 25 Nov 2006 08:18:14 +0100 298746 http://www.medworm.com/index.php?rid=298737&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk7176gl821505165%2F In conclusion, the pepsinogen test method can be used as a screening test for high-risk subjects, rather than as a tool for screening for cancer itself. I hope that this pepsinogen test method will become a world standard for gastric cancer prevention in the near future, in other countries, as well as in Japan. Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 9 Journal IssueVolume 9, Number 4 / November, 2006 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=298737 Sat, 25 Nov 2006 08:18:14 +0100 298737 http://www.medworm.com/index.php?rid=298736&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb5u631g5151477g5%2F ConclusionLymphatic vessels are most densely distributed in the MM layer in the gastric wall. Immunohistochemical identification of lymphatics is useful to increase the accuracy of diagnosing Ly in resected gastric EGCs. Ly-IM is superior to Ly-HE as a predictor of nodal metastasis, at least for intestinal-type EGC. Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 9 Journal IssueVolume 9, Number 4 / November, 2006 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=298736 Sat, 25 Nov 2006 08:18:14 +0100 298736 http://www.medworm.com/index.php?rid=298745&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ftgg6118715m81t77%2F ConclusionThere were no differences in the efficacy ofH. pylorieradication between the two groups; therefore, the triple therapy regimen is effective for the eradication ofH. pyloriin gastrectomized patients with a Roux-en-Y reconstruction. Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 9 Journal IssueVolume 9, Number 4 / November, 2006 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=298745 Sat, 25 Nov 2006 08:18:11 +0100 298745 http://www.medworm.com/index.php?rid=298739&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj1041776321w8184%2F ConclusionIL-1RNpolymorphism increased the risk of GC in an Omani Arab population, consistent with previous reports. In contrast, theIL-1B−31 polymorphism was not associated with an increased GC risk. These findings underscore the role of cytokine gene polymorphisms in the development of GC and further support the ethnic differences in the effect ofIL-1Bpolymorphism on GC carcinogenesis. Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 9 Journal IssueVolume 9, Number 4 / November, 2006 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=298739 Sat, 25 Nov 2006 08:18:09 +0100 298739 http://www.medworm.com/index.php?rid=298744&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa36321852mw4542p%2F ConclusionsThe present study reproduced the significant association between theA/Agenotype and reduced risk of gastric atrophy among Japanese outside Japan. According to the Japan Single Nucleotide Polymorphisms (JSNP) database (db)SNP data, theGallele is very frequent among Japanese and rare in Caucasians. This fact may partly explain the distribution of gastric atrophy/cancer in the world. Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 9 Journal IssueVolume 9, Number 4 / November, 2006 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=298744 Sat, 25 Nov 2006 08:18:06 +0100 298744 http://www.medworm.com/index.php?rid=298738&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2671974821400864%2F ConclusionThe detection of small numbers of cancer cells in peritoneal wash samples from patients with advanced gastric cancer is a good marker for peritoneal metastatic recurrence. In the peritoneal cavity, cancer cells may escape from immune surveillance by controlling the expression of cytokines. Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 9 Journal IssueVolume 9, Number 4 / November, 2006 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=298738 Sat, 25 Nov 2006 08:18:04 +0100 298738 http://www.medworm.com/index.php?rid=298740&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr00125537tvw7vt2%2F ConclusionER leads to an excellent 3-year survival in clinical practice and could be a possible standard treatment for EGC. ESD has the advantage of achieving one-piece resection and reducing local residual or recurrent tumor. Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 9 Journal IssueVolume 9, Number 4 / November, 2006 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=298740 Sat, 25 Nov 2006 08:18:01 +0100 298740 http://www.medworm.com/index.php?rid=298748&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh225250652178x08%2F We report two patients with advanced gastric cancer with suspected paclitaxel-induced interstitial pneumonitis. Case 1, a 66-year-old man with recurrent gastric cancer, was treated weekly with paclitaxel. After 11 administrations of paclitaxel, he developed a nonproductive cough and dyspnea. Computed tomography (CT) scan showed extensive bilateral areas of ground-glass attenuation. He did not respond to corticosteroid, and died 57 days after the last paclitaxel administration. Case 2, a 61-year-old man with gastric cancer and liver metastasis, was treated with weekly paclitaxel. The liver metastasis was dramatically reduced in size, but he developed a nonproductive cough and dyspnea after 21 administrations of paclitaxel. He did not respond to high-dose corticosteroid, and died 50 days aft... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=298748 Sat, 25 Nov 2006 08:17:58 +0100 298748 http://www.medworm.com/index.php?rid=298742&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F972142h6v504n233%2F AbstractIn 2003, a 69-year-old man visited our emergency department because of hematemesis and anemia. Emergency gastroscopy revealed massive bleeding from Dieulafoy's ulcer in the upper body of the stomach. The arterial bleeding was successfully controlled by endoscopic clipping. Blood transfusion and a proton-pump inhibitor were administered and his condition recovered smoothly. Two weeks after the treatment, type IIa early gastric cancer was detected at the previous bleeding point by follow-up endoscopy. He underwent distal gastrectomy with systematic lymph node dissection (D2), and he had no sign of recurrence until 2005. Histopathological examination revealed an early gastric cancer with submucosal invasion located just above the Dieulafoy's disease. The characteristic finding of Dieu... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=298742 Sat, 25 Nov 2006 08:17:56 +0100 298742 http://www.medworm.com/index.php?rid=179587&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F22780r7h84l72551%2F Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 9 Journal IssueVolume 9, Number 3 / August, 2006 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=179587 Sat, 02 Sep 2006 07:28:34 +0100 179587 http://www.medworm.com/index.php?rid=179596&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F83506427624h37t2%2F In this study, we investigated clinicopathological findings and sentinel lymph nodes (SNs) for associations with micrometastases. We discuss the indications for endoscopic mucosal resection (EMR), reduced surgery, and sentinel node navigation surgery (SNNS) based on the results. Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 9 Journal IssueVolume 9, Number 3 / August, 2006 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=179596 Sat, 02 Sep 2006 07:28:33 +0100 179596 http://www.medworm.com/index.php?rid=179595&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1566264j057lp48p%2F Abstract  Since 1985, when gastric-type well-differentiated adenocarcinomas were demonstrated in hyperplastic polyps of the stomach, we have studied phenotypic expression in gastrointestinal epithelial lesions. The recent discovery of MUC genes coding core proteins of mucin has improved research on the phenotypic expression of gastrointestinal neoplasms. The disease entity of gastric-type well-differentiated adenocarcinoma has recently been accepted, especially in Japan and Europe. This entity has often become a clinicopathological subject of discussion, because its biological behavior is possibly highly malignant, in spite of the difficulty in making endoscopic and histopathological diagnoses. Even under these circumstances, the term “gastric adenoma” usually means flat adenoma... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=179595 Sat, 02 Sep 2006 07:28:33 +0100 179595 http://www.medworm.com/index.php?rid=179594&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq21655356g715t55%2F Abstract  Since 1991, laparoscopic surgery has been adopted for the treatment of gastric cancer, and it has been performed worldwide, especially in Japan and Korea. We reviewed the English-language literature to clarify the current status of and problems associated with laparoscopic gastrectomy with lymph node dissection as treatment for gastric cancer. In Japan, early-stage gastric cancer (T1/T2, N0) is considered the only indication for laparoscopic gastrectomy. As yet, there is little high-level evidence based on long-term outcome supporting laparoscopic gastrectomy for cancer, but reports have provided level 3 evidence that the procedure is technically safe, and that it yields better short-term outcomes than open surgery; that is, recovery is faster, hospital stay is shorter, t... Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=179594 Sat, 02 Sep 2006 07:28:33 +0100 179594 http://www.medworm.com/index.php?rid=179593&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F934212rp3331842w%2F Abstract Background  The present study of Helicobacter pylori infection was conducted in family units of Japanese Brazilians living in São Paulo city. The authors attempted to determine the seroprevalence of H. pylori infection within family units of Japanese Brazilians and to identify risk factors associated with intrafamilial transmission. Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 9 Journal IssueVolume 9, Number 3 / August, 2006 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=179593 Sat, 02 Sep 2006 07:28:33 +0100 179593 http://www.medworm.com/index.php?rid=179592&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh74r852178004h01%2F Abstract Background  Gastric cancer can present with the endoscopic appearances of a benign gastric ulcer (GU). Opinion remains divided on the need for follow-up of patients diagnosed with GU, and the aim of this study was to examine the long-term outcomes of patients whose GU proved malignant on follow-up gastroscopy. Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 9 Journal IssueVolume 9, Number 3 / August, 2006 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=179592 Sat, 02 Sep 2006 07:28:33 +0100 179592 http://www.medworm.com/index.php?rid=179585&cid=s_33402_17_f&fid=33402&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr514645h5m32m4r1%2F In this study, we examined the extent and characteristics of LI heterogeneity in gastric GISTs. Content TypeJournal Article JournalGastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal VolumeVolume 9 Journal IssueVolume 9, Number 3 / August, 2006 (Source: Gastric Cancer) Gastric Cancer journals http://www.medworm.com/rss/comments.php?id=179585 Sat, 02 Sep 2006 07:28:33 +0100 179585