Gastroenterology via MedWorm.com MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Gastroenterology' source. Sat, 20 Mar 2010 14:19:15 +0100 Copyright Assignment, Authorship Responsibility, NIH Funding, Financial Disclosure, Institutional Review Board/Animal Care Committee Approval, and Sponsorship http://www.medworm.com/index.php?rid=3324424&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510001198%2Fabstract%3Frss%3Dyes Copyright Assignment. In consideration of the American Gastroenterological Association (AGA) Institute (the “AGA Institute”) taking action to review and credit the below-identified submission (the “Manuscript”), and for other valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned authors and/or creators (the “Authors”), jointly and severally, hereby transfer, convey, and assign to the AGA Institute, free and clear of any liens, licenses or encumbrances, the entire right, title, and interest in and to the Manuscript throughout the world, including without limitation in and to any and all copyrights for the Manuscript (including but not limited to rights to copy, publish, excerpt, collect royalties and make derivative works) in print,... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324424 Mon, 01 Mar 2010 00:00:00 +0100 3324424 Forthcoming Articles http://www.medworm.com/index.php?rid=3324423&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510001150%2Fabstract%3Frss%3Dyes Distinct Effects of p38α Deletion in Myeloid Lineage and Gut Epithelia in Mouse Models of Inflammatory Bowel Disease Motoyuki Otsuka, Young Jun Kang, Jianlin Ren, Huiping Jiang, Yinbin Wang, Masao Omata, and Jiahuai Han (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324423 Mon, 01 Mar 2010 00:00:00 +0100 3324423 Information for Authors and Readers http://www.medworm.com/index.php?rid=3324422&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510001149%2Fabstract%3Frss%3Dyes Gastroenterology is the premiere journal in the field of gastrointestinal disease and is led by an internationally renowned board of editors. As the official journal of the AGA Institute, Gastroenterology delivers up-to-date and authoritative coverage of both basic and clinical gastroenterology and hepatology. Regular features include research and perspectives by leading authorities, reports on the latest technologies for diagnosing and treating digestive diseases, images illustrating important clinical findings, reviews of scholarly media, medical news, meeting summaries, video abstracts, and monthly podcasts. Gastroenterology also bridges the gap between basic and clinical science by publishing comprehensive reviews on important topics such as pancreatitis and liver disease. (Source: Gas... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324422 Mon, 01 Mar 2010 00:00:00 +0100 3324422 Table of Contents http://www.medworm.com/index.php?rid=3324421&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510001137%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324421 Mon, 01 Mar 2010 00:00:00 +0100 3324421 Editorial Board http://www.medworm.com/index.php?rid=3324420&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510001125%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324420 Mon, 01 Mar 2010 00:00:00 +0100 3324420 Cover 1 http://www.medworm.com/index.php?rid=3324419&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510001101%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324419 Mon, 01 Mar 2010 00:00:00 +0100 3324419 Information for Authors http://www.medworm.com/index.php?rid=3324418&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS001650851000140X%2Fabstract%3Frss%3Dyes Gastroenterology publishes clinical and basic studies of all aspects of the digestive system, including the liver and pancreas, as well as nutrition. The types of articles Gastroenterology publishes include original papers, review articles, and special category manuscripts. Manuscripts must be prepared in accordance with the “Uniform Requirements for Manuscripts Submitted to Biomedical Journals” developed by the International Committee of Medical Journal Editors (http://www.icmje.org). Gastroenterology is a member of the Committee on Publication Ethics (COPE) (http://www.publicationethics.org.uk). (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324418 Mon, 01 Mar 2010 00:00:00 +0100 3324418 Correction http://www.medworm.com/index.php?rid=3324417&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510001642%2Fabstract%3Frss%3Dyes Dassopoulos T, Inadomi JM, Lewis JD, et al. The Development of Clinical Guidelines by the American Gastroenterology Association. Gastroenterology 2010;138:417–418. In the above article, the author affiliations appeared transposed for John M. Inadomi, MD and John I. Allen, MD, MBA, AGAF. The correct affiliations are as follows: John M. Inadomi, MD, San Francisco General Hospital University of California, San Francisco. John I. Allen, MD, MBA, AGAF, Minnesota Gastroenterology PA, University of Minnesota School of Medicine. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324417 Mon, 08 Feb 2010 00:00:00 +0100 3324417 Correction http://www.medworm.com/index.php?rid=3324416&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510001630%2Fabstract%3Frss%3Dyes Shiffman ML, Morishima C, Dienstag JL, et al. Effect of HCV RNA suppression during peginterferon alfa-2a maintenance therapy on clinical outcomes in the HALT-C trial. Gastroenterology 2009;137:1986–1994. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324416 Mon, 08 Feb 2010 00:00:00 +0100 3324416 Glowing in the Dark: Not Always a Bad Thing http://www.medworm.com/index.php?rid=3324366&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509009962%2Fabstract%3Frss%3Dyes Question: A 55-year-old male long-distance runner of many years underwent evaluation for an unusual movement disorder of the right lower extremity. During the evaluation, a magnetic resonance angiogram of the abdomen, pelvis, and lower extremities was performed to rule out intimal thickening and kinking of pelvic arteries that could have contributed to some of his symptoms. An incidental finding of a 1.7-cm lesion on the right lobe of the liver was identified (, arrow). (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324366 Mon, 01 Feb 2010 00:00:00 +0100 3324366 The Death of the Pen http://www.medworm.com/index.php?rid=3324357&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510000958%2Fabstract%3Frss%3Dyes As I rounded on our inpatient service recently, I realized simultaneously that I had forgotten my pen—and that it didn't matter. I am uncertain whether to lament or marvel as we move beyond one of the great technological developments of our time: the use of pen and paper. As physicians, we have come to expect a pen in our pocket and a stethoscope around our neck. Both habits are changing, but I will focus on the pen. This change will have important implications for how we practice and discover new knowledge in medicine. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324357 Mon, 01 Feb 2010 00:00:00 +0100 3324357 This Month in Gastroenterology http://www.medworm.com/index.php?rid=3324351&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510001010%2Fabstract%3Frss%3Dyes Chronic constipation is a highly prevalent condition characterized by infrequent bowel movements with hard stool consistency, straining during evacuation, and abdominal discomfort and bloating. Traditionally, chronic constipation is managed by life style and dietary modifications, with addition of laxatives and stool softeners in many cases. More recently, lubiprostone, a chloride channel activator, was shown to be effective in the treatment of chronic constipation. Despite these modalities, a large proportion of patients remains incompletely relieved with currently available therapeutic approaches. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324351 Mon, 01 Feb 2010 00:00:00 +0100 3324351 Copyright Assignment, Authorship Responsibility, NIH Funding, Financial Disclosure, Institutional Review Board/Animal Care Committee Approval, and Sponsorship http://www.medworm.com/index.php?rid=3229087&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509022148%2Fabstract%3Frss%3Dyes Copyright Assignment. In consideration of the American Gastroenterological Association (AGA) Institute (the “AGA Institute”) taking action to review and credit the below-identified submission (the “Manuscript”), and for other valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned authors and/or creators (the “Authors”), jointly and severally, hereby transfer, convey, and assign to the AGA Institute, free and clear of any liens, licenses or encumbrances, the entire right, title, and interest in and to the Manuscript throughout the world, including without limitation in and to any and all copyrights for the Manuscript (including but not limited to rights to copy, publish, excerpt, collect royalties and make derivative works) in print,... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229087 Mon, 01 Feb 2010 00:00:00 +0100 3229087 Forthcoming Articles 4 http://www.medworm.com/index.php?rid=3229086&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509022136%2Fabstract%3Frss%3Dyes Cell-Type Specific Gene Expression Signature in Liver Underlies Response to Interferon Therapy in Chronic Hepatitis C Infection Limin Chen, Ivan Borozan, Jing Sun, Maha Guindi, Sandra Fischer, Jordan Feld, Nitasha Anand, Jenny Heathcote, Aled M. Edwards, and Ian D. McGilvray (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229086 Mon, 01 Feb 2010 00:00:00 +0100 3229086 Forthcoming Articles 3 http://www.medworm.com/index.php?rid=3229085&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509022124%2Fabstract%3Frss%3Dyes Conditional Deletion of Ikappab-Kinase Beta (Ikkβ) Accelerates Helicobacter-Dependent Gastric Apoptosis, Proliferation and Preneoplasia Wataru Shibata, Shigeo Takaishi, Sureshkumar Muthupalani, D. Mark Pritchard, Mark T. Whary, Arlin B. Rogers, James G. Fox, Kelly S. Betz, Klaus H. Kaestner, Michael Karin, and Timothy C. Wang (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229085 Mon, 01 Feb 2010 00:00:00 +0100 3229085 Forthcoming Articles 2 http://www.medworm.com/index.php?rid=3229084&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509022112%2Fabstract%3Frss%3Dyes Adverse Outcomes in Alaska Natives Who Recovered From or Have Chronic Hepatitis C Infection Brian J. McMahon, Dana Bruden, Michael G. Bruce, Stephen Livingston, Carol Christensen, Chriss Homan, Thomas W. Hennessy, James Williams, Daniel Sullivan, Hugo R. Rosen, and David Gretch (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229084 Mon, 01 Feb 2010 00:00:00 +0100 3229084 Forthcoming Articles 1 http://www.medworm.com/index.php?rid=3229083&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509022100%2Fabstract%3Frss%3Dyes Comparison of Probe Based Confocal Laser Endomicroscopy With Virtual Chromoendoscopy for Classification of Colon Polyps Anna M. Buchner, Muhammad W. Shahid, Michael G. Heckman, Murli Krishna, Marwan Ghabril, Muhammad Hasan, Julia E. Crook, Victoria Gomez, Massimo Raimondo, Timothy Woodward, HerbertC. Wolfsen, and Michael B. Wallace (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229083 Mon, 01 Feb 2010 00:00:00 +0100 3229083 Information for Authors and Readers http://www.medworm.com/index.php?rid=3229082&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509022094%2Fabstract%3Frss%3Dyes Gastroenterology is the premiere journal in the field of gastrointestinal disease and is led by an internationally renowned board of editors. As the official journal of the AGA Institute, Gastroenterology delivers up-to-date and authoritative coverage of both basic and clinical gastroenterology and hepatology. Regular features include research and perspectives by leading authorities, reports on the latest technologies for diagnosing and treating digestive diseases, images illustrating important clinical findings, reviews of scholarly media, medical news, meeting summaries, video abstracts, and monthly podcasts. Gastroenterology also bridges the gap between basic and clinical science by publishing comprehensive reviews on important topics such as pancreatitis and liver disease. (Source: Gas... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229082 Mon, 01 Feb 2010 00:00:00 +0100 3229082 Table of Contents http://www.medworm.com/index.php?rid=3229081&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509022082%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229081 Mon, 01 Feb 2010 00:00:00 +0100 3229081 Editorial Board http://www.medworm.com/index.php?rid=3229080&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509022070%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229080 Mon, 01 Feb 2010 00:00:00 +0100 3229080 Cover 1 http://www.medworm.com/index.php?rid=3229079&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509022057%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229079 Mon, 01 Feb 2010 00:00:00 +0100 3229079 Information for Authors http://www.medworm.com/index.php?rid=3229078&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509022367%2Fabstract%3Frss%3Dyes Gastroenterology publishes clinical and basic studies of all aspects of the digestive system, including the liver and pancreas, as well as nutrition. The types of articles Gastroenterology publishes include original papers, review articles, and special category manuscripts. Manuscripts must be prepared in accordance with the “Uniform Requirements for Manuscripts Submitted to Biomedical Journals” developed by the International Committee of Medical Journal Editors (http://www.icmje.org). Gastroenterology is a member of the Committee on Publication Ethics (COPE) (http://www.publicationethics.org.uk). (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229078 Mon, 01 Feb 2010 00:00:00 +0100 3229078 Correction http://www.medworm.com/index.php?rid=3229077&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509022458%2Fabstract%3Frss%3Dyes Colletti M, Cicchini C, Conigliaro A, et al. Convergence of Wnt signaling on the HNF4alpha-driven transcription in controlling liver zonation. Gastroenterology 2009;137:660–672. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229077 Mon, 01 Feb 2010 00:00:00 +0100 3229077 Correction http://www.medworm.com/index.php?rid=3229076&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509022446%2Fabstract%3Frss%3Dyes Wong RC. Nonvariceal upper gastrointestinal hemorrhage: probing beneath the surface. Gastroenterology 2009;137:1897–1902. On page 1900 in the above article, the final sentence of the 3rd paragraph incorrectly notes a 0.7 mm gastric ulcer as a cause of recurrent GI bleeding. The sentence should correctly read, “Finally, it is also uncertain whether current EUS imaging has sufficient resolution to reliably detect blood flow in subsurface vessels associated with bleeding peptic ulcers, which, in a seminal study on recurrently bleeding gastric ulcers (Swain et al17), the bleeding artery had a mean external diameter of 0.7 mm (range 0.1–1.8 mm).” to denote that the bleeding artery, (not ulcer) was the cause of recurrent GI bleeding. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229076 Mon, 01 Feb 2010 00:00:00 +0100 3229076 Correction http://www.medworm.com/index.php?rid=3229075&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509022434%2Fabstract%3Frss%3Dyes Lindley RM, Hawcutt DB, Connell MG, et al. Human and mouse enteric nervous system neurosphere transplants regulate the function of aganglionic embryonic distal colon. Gastroenterology 2008;135:205–216. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229075 Mon, 01 Feb 2010 00:00:00 +0100 3229075 AGA Technical Review on the Diagnosis and Management of Colorectal Neoplasia in Inflammatory Bowel Disease http://www.medworm.com/index.php?rid=3229060&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509022008%2Fabstract%3Frss%3Dyes Podcast interview: www.gastro.org/gastropodcast. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229060 Mon, 01 Feb 2010 00:00:00 +0100 3229060 AGA Medical Position Statement on the Diagnosis and Management of Colorectal Neoplasia in Inflammatory Bowel Disease http://www.medworm.com/index.php?rid=3229059&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509022021%2Fabstract%3Frss%3Dyes The AGA Institute Medical Position Panel consisted of the authors of the technical review, a community-based gastroenterologist (Robert P. McCabe, MD, Minnesota Gastroenterology), academic-based gastroenterologists (Themistocles Dassopoulos, MD, James D. Lewis, MD, and Thomas A. Ullman, MD), an insurance provider representative (Tom James III, MD Physician Advisor, Strategic Advisory Group, Humana), a colon and rectal surgeon (Robin McLeod, MD, Mount Sinai Hospital-Canada), a pathologist (Lawrence J. Burgart, MD, Minnesota Gastroenterology), chair of the AGA Institute Clinical Practice and Quality Management Committee (John Allen, MD, Minnesota Gastroenterology), and chair of the Practice Management and Economics Committee (Joel V. Brill, MD, Predictive Health, LLC). (Source: Gastroenterol... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229059 Mon, 01 Feb 2010 00:00:00 +0100 3229059 A 79-Year-Old Patient With Yellow Sputum http://www.medworm.com/index.php?rid=3324363&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509011342%2Fabstract%3Frss%3Dyes Question: A 79-year-old woman was admitted with a 2-day history of vomiting, malaise, and nocturnal yellowish stained cough. She denied having fever or pain. One month earlier she has had an episode of Escherichia coli pneumonia and sepsis. Her history included a cholecystectomy 9 months ago. Postoperatively, a benign bile duct stenosis had caused recurrent episodes of cholangitis and was treated by repeated endoscopic stenting. Furthermore, paroxysmal atrial fibrillation, coronary artery disease, and type 2 diabetes mellitus were present. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324363 Fri, 29 Jan 2010 00:00:00 +0100 3324363 The Role of Iron in Nonalcoholic Fatty Liver Disease: The Story Continues http://www.medworm.com/index.php?rid=3324359&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510000879%2Fabstract%3Frss%3Dyes See “HFE genotype, parenchymal iron accumulation, and liver fibrosis in patients with nonalcoholic fatty liver disease,” by Valenti L, Fracanzani AL, Bugianesi E, et al, on page 905. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324359 Fri, 29 Jan 2010 00:00:00 +0100 3324359 March CME Exam 2 Questions http://www.medworm.com/index.php?rid=3324404&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510000752%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324404 Thu, 28 Jan 2010 00:00:00 +0100 3324404 Unusual Tumor That Presented With Rectal Bleeding http://www.medworm.com/index.php?rid=3324365&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509009950%2Fabstract%3Frss%3Dyes Question: A 53-year-old man received a health check-up and showed a positive occult blood in the stool. He has no tenesmus, no abdominal pain, no bowel habit changes, and no small-caliber stool. There was also no palpitation, no hot flushes, and no loss of body weight. Colonoscopy revealed a rectal polyp with a broad base, found proximally 6 cm from the anal verge (). Biopsy was performed and the pathologic examination showed tubulovillous adenoma with focal malignant change. A low anterior resection was performed. Two separate parts of the tumor were seen on the cut surface (). (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324365 Thu, 28 Jan 2010 00:00:00 +0100 3324365 Taking a Lesson From Microbial Diarrheagenesis in the Management of Chronic Constipation http://www.medworm.com/index.php?rid=3324358&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510000867%2Fabstract%3Frss%3Dyes See “Efficacy of linaclotide for patients with chronic constipation,” by Lembo AJ, Kurtz CR, MacDougall JE, et al, on page 886. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324358 Thu, 28 Jan 2010 00:00:00 +0100 3324358 An Unusual Cause of Abdominal Pain in a Cirrhotic Patient http://www.medworm.com/index.php?rid=3324364&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510000466%2Fabstract%3Frss%3Dyes Question: A 57-year-old woman presented to the emergency department (ED) with fever, chills, and right upper-quadrant abdominal pain for further evaluation. She had a history of chronic hepatitis C–related liver cirrhosis and a gallbladder stone. Sclerotherapy was previously applied for gastric varices bleeding. In the ED, the blood counts were the following: white blood cells, 10,700/mm3 (normal, 4,800–10,800/mm3), hemoglobin, 13 g/dL (normal, 12–16), and platelets 34,000/mm3 (normal, 130,000–400,000/mm3). The differential count of white blood cell was neutrophils, 95%; lymphocytes, 2%; monocytes, 3%; eosinophils, 0%; and basophils, 0%. Serum biochemistry test results were as follows: alanine aminotransferase, 16 IU/L (normal, 0–40), γ-glutamyltransferase, 26 U/L (normal, 8–6... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324364 Wed, 27 Jan 2010 00:00:00 +0100 3324364 Reply http://www.medworm.com/index.php?rid=3324415&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510001071%2Fabstract%3Frss%3Dyes We would first like to respond directly to some aspects raised in Smith et al. As stated in our paper, we applied similar resting tension to our preparations (5–10 mN) to that of Heredia et al (8 mN). Additionally, we never measured basal CMMC amplitudes close to 150 mN, as suggested; these authors seem confused with CMMC amplitudes of this magnitude that were evoked by the focal application of 5-HT to the myenteric plexus (Keating and Spencer; Figure 6B). Our CMMC amplitudes (average 30–50 mN; Figure 3C) are of a similar magnitude to those in traces provided by Heredia et al. Any differences in mean CMMC properties between our 2 studies are most likely due to the use of an open sheet conformation, as opposed to the intact tube used by Heredia et al. Furthermore, we find that in the ab... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324415 Mon, 25 Jan 2010 00:00:00 +0100 3324415 Controversies Involving the Role of 5-Hydroxytryptamine in Generating Colonic Migrating Motor Complexes: What Is Spontaneous? http://www.medworm.com/index.php?rid=3324414&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS001650851000003X%2Fabstract%3Frss%3Dyes It is important to understand and elucidate the mechanisms underlying the colonic migrating motor complex (CMMC), because it is a primary motor event in the large bowel that assists in the movement of fecal contents. Recently, Keating and Spencer used tension recordings and real-time amperometry to determine the role of 5-hydroxytryptamine (5-HT) in generating CMMCs in the isolated mouse colon. They make a number of conclusions that seem to contradict our recent study. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324414 Mon, 25 Jan 2010 00:00:00 +0100 3324414 Intestinal Disorders, Falk Symposium 164 http://www.medworm.com/index.php?rid=3324413&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510000831%2Fabstract%3Frss%3Dyes The aim of this book is to provide an up-to-date review of the clinical, pathologic, and genetic advances in intestinal disorders. It is a compilation of the proceedings of the Falk Symposium 164 entitled “Intestinal Disorders,” held in Budapest, Hungary, on May 2–3, 2008. The lectures are mainly written and edited by European authors and give a slightly different perspective than the usual treatment algorithms one encounters in US gastroenterology. For example, there are some data on using mesalamine drugs and probiotics to prevent and treat diverticulitis and on novel agents used to treat irritable bowel syndrome. Because the Falk Symposium occurred about 1.5 years ago, recent data that have been reported are not included. Two examples are new data on prevention and treatment of di... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324413 Mon, 25 Jan 2010 00:00:00 +0100 3324413 Atlas of Pancreatic Cytopathology with Histopathologic Correlation http://www.medworm.com/index.php?rid=3324412&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS001650851000082X%2Fabstract%3Frss%3Dyes With the advent and recent advances in endoscopic ultrasound-guided fine needle aspiration of lesions of the gastrointestinal tract, particularly the pancreas, the Atlas of Pancreatic Cytopathology with Histopathologic Correlations is a welcome addition to the literature. Just as the name explicitly states, this hardback book superbly correlates the cytopathology of pancreatic lesions with the histopathology. Being part of The Sol Goldman Pancreatic Cancer Research Center at The Johns Hopkins University, in a very practical atlas, the world-renowned authors have compiled their personal experience with a number of pancreatic lesions sampled by the 2 commonly used imaging techniques—ultrasonography and computer-assisted tomography (CT). Practicing surgical pathologists and cytopathologists... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324412 Mon, 25 Jan 2010 00:00:00 +0100 3324412 Recent Advances in Gastroenterology http://www.medworm.com/index.php?rid=3324411&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510000818%2Fabstract%3Frss%3Dyes Chris Probert's Recent Advances in Gastroenterology provides a review of recent “hot topics” in gastroenterology. The primary aim of this 220-page review book, as stated by Dr Probert, the book's editor, is to help educate gastroenterology fellows, medical residents, and general practitioners who are developing subspecialty clinics. The book is also intended to help update gastroenterologists in a variety of topics. I believe that Dr Probert and his colleagues have achieved their goals. With respect to general content, including chapters on eosinophilic esophagitis, Barrett's esophagus, bariatric surgery, nonalcoholic fatty liver disease, irritable bowel syndrome, and inflammatory bowel disease is appropriate and necessary given not only the recent advances made in these fields, but al... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324411 Mon, 25 Jan 2010 00:00:00 +0100 3324411 Bile Acid Mimetic-Activated TGR5 Receptor in Metabolic-Related Liver Disorder: The Good and the Bad http://www.medworm.com/index.php?rid=3324410&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510000934%2Fabstract%3Frss%3Dyes Thomas C, Gioiello A, Noriega L, et al. (Institut de Génétique et Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Illkirch, France). TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab 2009;10:167–177. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324410 Mon, 25 Jan 2010 00:00:00 +0100 3324410 Reply http://www.medworm.com/index.php?rid=3324409&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510000909%2Fabstract%3Frss%3Dyes We thank Drs Salas and Panés for their excellent summary. However, there seems to be a general misunderstanding of the relationship between genes like those for NOD2 and ATG16L1 and the causation of Crohn's disease (CD). The associated abnormalities in these genes are neither necessary nor sufficient to cause the disease. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324409 Mon, 25 Jan 2010 00:00:00 +0100 3324409 The 2-Phase Model of Crohn's Disease: From Immune Defect to Hyperresponse http://www.medworm.com/index.php?rid=3324408&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510000892%2Fabstract%3Frss%3Dyes Smith AM, Rahman FZ, Hayee B, et al. (Department of Medicine, University College London, London, UK). Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease. J Exp Med 2009;206:1883–1897. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324408 Mon, 25 Jan 2010 00:00:00 +0100 3324408 miRNA Delivery: Emerging Therapy for Hepatocellular Carcinoma http://www.medworm.com/index.php?rid=3324407&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510000880%2Fabstract%3Frss%3Dyes Kota J, Chivukula RR, O'Donnell KA, et al. (Center for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio). Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell 2009;137:1005–1017. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324407 Mon, 25 Jan 2010 00:00:00 +0100 3324407 Reply http://www.medworm.com/index.php?rid=3324406&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510000922%2Fabstract%3Frss%3Dyes Robertson and Dominitz adequately pointed out the issues raised in our multicenter trial comparing colon capsule and standard colonoscopy for the detection of polyps and cancer (N Engl J Med 2009;361:264–270). Indeed, colon preparation is currently among the major concerns and is significantly more demanding with capsule colonoscopy. It accounts at least in part for the low sensitivity. As an example, out of the 5 missed cancers at colon capsule, 3 patients had a poor preparation, 1 lesion was located in the rectum in a patient in whom the capsule batteries expired in the sigmoid, and the last patient had 6 other polyps (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324406 Mon, 25 Jan 2010 00:00:00 +0100 3324406 Colon Capsule Endoscopy: Fantastic Voyage or Ship Adrift in Murky Waters? http://www.medworm.com/index.php?rid=3324405&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510000910%2Fabstract%3Frss%3Dyes Van Gossum A, Munoz-Navas M, Fernandez-Urien I, et al. (Department of Gastroenterology, Erasme Univeristy Hospital, Université Libre de Bruxelles, Brussels, Belgium). Capsule endoscopy versus colonoscopy for the detection of polyps and cancer. N Engl J Med 2009;361:264–270. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324405 Mon, 25 Jan 2010 00:00:00 +0100 3324405 Introduction From the New Editors for Imaging and Advanced Technology http://www.medworm.com/index.php?rid=3324367&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510001083%2Fabstract%3Frss%3Dyes The reclusive American poet Emily Dickinson is said to only have allowed doctors to “examine” her as she walked past an open door several feet away. Dickinson, who died of renal failure, was perhaps looking ahead at a future of medical imaging where diagnoses can be made with pinpoint accuracy without the physician even being in the same room. Such a future is here today, and those of us in clinical medicine are particularly fortunate to be in the midst of a far-reaching revolution in diagnostic and therapeutic technology that has transformed the way we take care of our patients. At the same time, the pace of biological discovery is being accelerated dramatically by the introduction of remarkable technological innovations for the analysis and imaging of cellular, subcellular, and molec... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324367 Mon, 25 Jan 2010 00:00:00 +0100 3324367 An Unusual Case of Rectal Bleeding and Hemospermia http://www.medworm.com/index.php?rid=3324362&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509012578%2Fabstract%3Frss%3Dyes Question: A 29-year-old man presented to the colorectal clinic complaining of a 1-month history of mild fresh rectal bleeding. Over the past 5 months, he also noticed blood in his semen. This subsequently became yellow, discolored, and developed a lumpy texture before presentation. No additional symptoms were reported. He also had no significant past medical history and was not on any regular medications. His family history revealed cancers of the bladder and prostate; however, no colonic polyposis or bowel cancer was reported. He smokes and drinks alcohol occasionally and works as an architect. On examination his abdomen was soft and nontender with no palpable masses. Digital rectal examination revealed a roughened and thickened fold of mucosa palpated in the lower rectum. A rigid sigmoid... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324362 Mon, 25 Jan 2010 00:00:00 +0100 3324362 Tracking Down the Hedgehog's Lair in the Pancreas http://www.medworm.com/index.php?rid=3324361&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510000855%2Fabstract%3Frss%3Dyes See “Pancreatic duct glands are distinct ductal compartments that react to chronic injury and mediate Shh-induced metaplasia,” by Strobel O, Roscow DE, Rakhlin EY, et al, on page 1166. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324361 Mon, 25 Jan 2010 00:00:00 +0100 3324361 A Knockout for Lynch Syndrome http://www.medworm.com/index.php?rid=3324360&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510000843%2Fabstract%3Frss%3Dyes See “An Msh2 conditional knockout mouse for studying intestinal cancers and testing anticancer agents,” by Kucherlapati MH, Lee K, Nguyen AA, et al, on page 993. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324360 Mon, 25 Jan 2010 00:00:00 +0100 3324360 Molecular Imaging in Gastrointestinal Endoscopy http://www.medworm.com/index.php?rid=3324368&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510000612%2Fabstract%3Frss%3Dyes Molecular imaging is a rapidly growing new discipline in gastrointestinal endoscopy. It uses the molecular signature of cells for minimally-invasive, targeted imaging of gastrointestinal pathologies. Molecular imaging comprises wide field techniques for the detection of lesions and microscopic techniques for in vivo characterization. Exogenous fluorescent agents serve as molecular beacons and include labeled peptides and antibodies, and probes with tumor-specific activation. Most applications have aimed at improving the detection of gastrointestinal neoplasia with either prototype fluorescence endoscopy or confocal endomicroscopy, and first studies have translated encouraging results from rodent and tissue models to endoscopy in humans. Even with the limitations of the currently used appro... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324368 Fri, 22 Jan 2010 00:00:00 +0100 3324368 Current and Future Trends in Liver Transplantation in Europe http://www.medworm.com/index.php?rid=3324356&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510000946%2Fabstract%3Frss%3Dyes The first human orthotopic liver transplantation (OLT) in Europe was performed by Sir Roy Calne of the University of Cambridge, United Kingdom, in 1968, only 1 year after the first successful human OLT reported by Thomas Starzl in the United States. Since then, >80,000 OLT have been performed in Europe. The overall results have dramatically improved over time with a current 5-year survival at 71%, in contrast with 21% in the mid 1980s, and 52%–65% for the period extending from 1985 to 19943 (). Several landmark advances have contributed to this success, such as the introduction of new immunosuppressive agents and preservation solutions, refinement and standardization of operative techniques, as well as earlier diagnosis and treatment of postoperative complications. This stepwise improvem... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324356 Fri, 22 Jan 2010 00:00:00 +0100 3324356 Gastrointestinal Response to Injury at the 2010 Freston Conference http://www.medworm.com/index.php?rid=3324355&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510000776%2Fabstract%3Frss%3Dyes This year's James W. Freston Single Topic Conference funded by the Takeda Endowment will be Gastrointestinal Response to Injury: 2010 and will be held from September 28 to October 2, 2010, at the Intercontinental Montelucia Resort & Spa in Scottsdale, Arizona. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324355 Fri, 22 Jan 2010 00:00:00 +0100 3324355 High Risk of Colorectal, Endometrial, and Lynch Syndrome Cancers for MSH6 Mutation Carriers http://www.medworm.com/index.php?rid=3324354&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510000788%2Fabstract%3Frss%3Dyes Persons carrying the germ-line MSH6 mutation are at high risk by 80 years of age for colorectal and endometrial cancers as well as any cancer associated with Lynch syndrome, according to a new study published online December 22, 2009 in the Journal of the National Cancer Institute. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324354 Fri, 22 Jan 2010 00:00:00 +0100 3324354 Annual Report to the Nation Highlights Declines in Colorectal Cancer http://www.medworm.com/index.php?rid=3324353&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510000806%2Fabstract%3Frss%3Dyes Colorectal cancer rates fell 22% from 1975 to 2000 in the United States, and deaths attributed to the disease fell 26% during the same period because of increased screening, changes in risk factors, and improved treatment, according to the “Annual Report to the Nation on the Status of Cancer, 1975–2006.” The report was published early online (December 7, 2009) in the journal Cancer. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324353 Fri, 22 Jan 2010 00:00:00 +0100 3324353 Health Spending Growth at Historic Low in 2008 http://www.medworm.com/index.php?rid=3324352&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS001650851000079X%2Fabstract%3Frss%3Dyes National health spending slowed dramatically amid the worst economic recession in recent history, growing by 4.4% in 2008, its slowest rate over the past 48 years, federal analysts reported in the January issue of the journal Health Affairs. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324352 Fri, 22 Jan 2010 00:00:00 +0100 3324352 History, Molecular Mechanisms, and Endoscopic Treatment of Barrett's Esophagus http://www.medworm.com/index.php?rid=3324371&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510000181%2Fabstract%3Frss%3Dyes This report is an adjunct to the American Gastroenterological Association Institute's medical position statement and technical review on the management of Barrett's esophagus, which will be published in the near future. Those documents will consider a number of broad questions on the diagnosis, clinical features, and management of patients with Barrett's esophagus, and the reader is referred to the technical review for an in-depth discussion of those topics. In this report, we review historical, molecular, and endoscopic therapeutic aspects of Barrett's esophagus that are of interest to clinicians and researchers. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324371 Mon, 18 Jan 2010 00:00:00 +0100 3324371 Efficacy of Linaclotide for Patients With Chronic Constipation http://www.medworm.com/index.php?rid=3324374&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509022471%2Fabstract%3Frss%3Dyes Conclusions: Linaclotide therapy was associated with few adverse events and produced rapid and sustained improvement of bowel habits, abdominal symptoms, global relief, and quality of life in patients with chronic constipation. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324374 Mon, 04 Jan 2010 00:00:00 +0100 3324374 An Unusual Liver Mass http://www.medworm.com/index.php?rid=3229026&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509009342%2Fabstract%3Frss%3Dyes Question: A 54-year-old man was admitted to our institution because of epigastric discomfort and no other symptoms. His medical history was unremarkable. Esophagogastroduodenoscopy revealed a chronic gastritis associated with Helicobacter pylori infection. Clinical examination was normal. Routine clinical laboratory parameters were within normal ranges. Hepatitis tests revealed positive HBs-antigen. Abdominal ultrasound revealed a hypoechoic lesion in the hepatic right lobe (VI–VII segment), bulging the hepatic capsule (, left). Contrast-enhanced ultrasonography was performed using second generation contrast media (sulfur hexafluoride; Bracco, Milan, Italy). The lesion showed no enhancement during arterial and was hypoechoic during portal and late phases (, right) corresponding with a hi... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229026 Mon, 28 Dec 2009 00:00:00 +0100 3229026 Information for Authors http://www.medworm.com/index.php?rid=3121448&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509020733%2Fabstract%3Frss%3Dyes Gastroenterology publishes clinical and basic studies of all aspects of the digestive system, including the liver and pancreas, as well as nutrition. The types of articles Gastroenterology publishes include original papers, review articles, and special category manuscripts. Manuscripts must be prepared in accordance with the “Uniform Requirements for Manuscripts Submitted to Biomedical Journals” developed by the International Committee of Medical Journal Editors (http://www.icmje.org). Gastroenterology is a member of the Committee on Publication Ethics (COPE) (http://www.publicationethics.org.uk). (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121448 Sat, 26 Dec 2009 14:12:31 +0100 3121448 Copyright Assignment, Authorship Responsibility, NIH Funding, Financial Disclosure, Institutional Review Board/Animal Care Committee Approval, and Sponsorship http://www.medworm.com/index.php?rid=3121447&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509020745%2Fabstract%3Frss%3Dyes Copyright Assignment. In consideration of the American Gastroenterological Association (AGA) Institute (the “AGA Institute”) taking action to review and credit the below-identified submission (the “Manuscript”), and for other valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned authors and/or creators (the “Authors”), jointly and severally, hereby transfer, convey, and assign to the AGA Institute, free and clear of any liens, licenses or encumbrances, the entire right, title, and interest in and to the Manuscript throughout the world, including without limitation in and to any and all copyrights for the Manuscript (including but not limited to rights to copy, publish, excerpt, collect royalties and make derivative works) in print,... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121447 Sat, 26 Dec 2009 14:12:28 +0100 3121447 Forthcoming Articles 4 http://www.medworm.com/index.php?rid=3121446&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509020721%2Fabstract%3Frss%3Dyes Heme Oxygenase-1 Protects Against Steatohepatitis Both in Cultured Hepatocytes and In Mice Jun Yu, Eagle S.H. Chu, Ruizhi Wang, Shiyan Wang, Chung W. Wu, Vincent W.S. Wong, Henry L.Y. Chan, Geoff Farrell, and Joseph J.Y. Sung (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121446 Sat, 26 Dec 2009 14:12:28 +0100 3121446 Forthcoming Articles 3 http://www.medworm.com/index.php?rid=3121445&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS001650850902071X%2Fabstract%3Frss%3Dyes 5-ASA Inhibits Epithelial β-Catenin Activation in Chronic Ulcerative Colitis Jeffrey B. Brown, Goo Lee, Elizabeth Managlia, Gery R. Grimm, Ramanarao Dirisina, Tatiana Goretsky, Paul Cheresh, Nichole R. Blatner, Khashayarsha Khazaie, Guang-Yu Yang, Linheng Li, and Terrence A. Barrett (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121445 Sat, 26 Dec 2009 14:12:27 +0100 3121445 Forthcoming Articles 2 http://www.medworm.com/index.php?rid=3121444&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509020708%2Fabstract%3Frss%3Dyes Peginterferon Alfa-2a/ribavirin for 48 or 72 Weeks in Hepatitis C Type 1 and 4 Patients With Slow Virological Response Peter Ferenci, Hermann Laferl, Thomas-Matthias Scherzer, Andreas Maieron, Harald Hofer, Rudolf Stauber, Michael Gschwantler, Harald Brunner, Christoph Wenisch, Martin Bischof, Michael Strasser, Christian Datz, Wolfgang Vogel, Karin Löschenberger, Petra Steindl-Munda, and the Austrian Hepatitis Study Group (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121444 Sat, 26 Dec 2009 14:12:27 +0100 3121444 Forthcoming Articles 1 http://www.medworm.com/index.php?rid=3121443&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509020691%2Fabstract%3Frss%3Dyes In Vivo Molecular Imaging of Colorectal Cancer With Confocal Endomicroscopy of Epidermal Growth Factor Receptor Martin Goetz, Alex Ziebart, Sebastian Foersch, Michael Vieth, Maximilian J. Waldner, Peter Delaney, Peter R. Galle, Markus F.Neurath, and Ralf Kiesslich (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121443 Sat, 26 Dec 2009 14:12:27 +0100 3121443 Information for Authors and Readers http://www.medworm.com/index.php?rid=3121442&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS001650850902068X%2Fabstract%3Frss%3Dyes Gastroenterology is the premiere journal in the field of gastrointestinal disease and is led by an internationally renowned board of editors. As the official journal of the AGA Institute, Gastroenterology delivers up-to-date and authoritative coverage of both basic and clinical gastroenterology and hepatology. Regular features include research and perspectives by leading authorities, reports on the latest technologies for diagnosing and treating digestive diseases, images illustrating important clinical findings, reviews of scholarly media, medical news, meeting summaries, video abstracts, and monthly podcasts. Gastroenterology also bridges the gap between basic and clinical science by publishing comprehensive reviews on important topics such as pancreatitis and liver disease. (Source: Gas... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121442 Sat, 26 Dec 2009 14:12:27 +0100 3121442 Table of Contents http://www.medworm.com/index.php?rid=3121441&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509020678%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121441 Sat, 26 Dec 2009 14:12:27 +0100 3121441 Editorial Board http://www.medworm.com/index.php?rid=3121440&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509020666%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121440 Sat, 26 Dec 2009 14:12:27 +0100 3121440 Cover 1 http://www.medworm.com/index.php?rid=3121372&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509020642%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121372 Sat, 26 Dec 2009 14:12:03 +0100 3121372 A Georgian Woman With Dysphagia and Stridor http://www.medworm.com/index.php?rid=3229025&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509012529%2Fabstract%3Frss%3Dyes See related article, Prince M et al, on page xxv in CGH. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229025 Fri, 25 Dec 2009 00:00:00 +0100 3229025 IBD Guide 2009 CME Exam 3 http://www.medworm.com/index.php?rid=3229058&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS001650850902201X%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229058 Wed, 23 Dec 2009 00:00:00 +0100 3229058 Colonoscopy: An Unusual Complication http://www.medworm.com/index.php?rid=3229022&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509018745%2Fabstract%3Frss%3Dyes See related article, Ko CW et al, on page 166 in CGH. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229022 Wed, 23 Dec 2009 00:00:00 +0100 3229022 The Role of Bile Acids in Gallstone-Induced Pancreatitis http://www.medworm.com/index.php?rid=3229021&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509021544%2Fabstract%3Frss%3Dyes See “Biliary acute pancreatitis in mice is mediated by the G-protein–coupled cell surface bile acid receptor Gpbar1,” by Perides G, Laukkarinen JM, Vassileva G, et al, on page 715. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229021 Wed, 23 Dec 2009 00:00:00 +0100 3229021 Sonic Hedgehog: A Link Between Inflammation, Gastric Atrophy, and Acid Suppression? http://www.medworm.com/index.php?rid=3229020&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509021556%2Fabstract%3Frss%3Dyes See “Loss of parietal cell expression of Sonic Hedgehog induces hypergastrinemia and hyperproliferation of surface mucous cells,” by Xiao C, Ogle SA, Schumacher MA, et al, on page 550; and “Interleukin-1β promotes gastric atrophy through suppression of Sonic Hedgehog,” by Waghray M, Zavros Y, Saqui–Salces M, et al, on page 562. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229020 Wed, 23 Dec 2009 00:00:00 +0100 3229020 IV or Not IV? Just One of the Antibiotic Questions in Whipple's Disease http://www.medworm.com/index.php?rid=3229019&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509021532%2Fabstract%3Frss%3Dyes See “Efficacy of ceftriaxone or meropenem as initial therapies in Whipple's disease,” by Feurle GE, Junga NS, Marth T, on page 478. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229019 Wed, 23 Dec 2009 00:00:00 +0100 3229019 The Development of Clinical Guidelines by the American Gastroenterological Association http://www.medworm.com/index.php?rid=3229017&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509021891%2Fabstract%3Frss%3Dyes Included in this issue of Gastroenterology is a medical position statement and technical review (TR) on the diagnosis and management of colorectal neoplasia in inflammatory bowel disease by Farraye et al. The American Gastroenterological Association (AGA) Institute Clinical Practice and Quality Management Committee (CPQMC) is charged with developing evidence-based, clinical practice guidelines. We take this opportunity to report on the mechanisms and challenges of the current AGA process for development of position statements, and to offer insight into procedures for their future development. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229017 Wed, 23 Dec 2009 00:00:00 +0100 3229017 Reply http://www.medworm.com/index.php?rid=3229074&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509022045%2Fabstract%3Frss%3Dyes The comments on our article by Moayyedi et al show that there is a great deal of agreement in the need for more high-quality, large-scale, randomized, controlled trials for the treatment of irritable bowel syndrome (IBS). Moayyedi et al do not disagree with many specific weaknesses identified in our commentary in individual trials included in many meta-analyses. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229074 Mon, 21 Dec 2009 00:00:00 +0100 3229074 The American College of Gastroenterology Irritable Bowel Syndrome Monograph: Translating Systematic Review Data to Clinical Practice http://www.medworm.com/index.php?rid=3229073&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509021064%2Fabstract%3Frss%3Dyes We write in response to the article by Drs Camilleri and Mayer in a recent issue of Gastroenterology. The article raises some concerns about the interpretation of systematic reviews and evidence-based medicine, in particular with regard to the recently updated American College of Gastroenterology (ACG) monograph on the management of irritable bowel syndrome (IBS). We agree with their general point of view and indeed have discussed these same issues in a recent article with a curiously similar title. There are, however, specific points they raise that need further clarification. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229073 Mon, 21 Dec 2009 00:00:00 +0100 3229073 Reply http://www.medworm.com/index.php?rid=3229072&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509022033%2Fabstract%3Frss%3Dyes We appreciate the interest of Dr Hsu and Dr Kao in our paper. Our response to the several comments in the order they were provided is as follows. Insulin resistance, as estimated by HOMA2, was the dominant weight-related risk factor for liver disease progression. However, we made no claim that insulin resistance caused clinical outcomes. We agree that interventions to reduce insulin resistance and related metabolic abnormalities should be evaluated in those with advanced hepatitis C disease. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229072 Mon, 21 Dec 2009 00:00:00 +0100 3229072 Role of Viral Factors in Modifying Weight-Related Effects on Disease Progression of Chronic Hepatitis C Patients http://www.medworm.com/index.php?rid=3229071&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509021076%2Fabstract%3Frss%3Dyes We read with great interest the article by Everhart et al. Their analyses were based on the data from the Hepatitis C Anti-viral Long-term Treatment Against Cirrhosis (HALT-C) trail, a prospective, randomized trial to evaluate the histologic and clinical outcomes of long-term, maintenance pegylated interferon on patients with chronic hepatitis C (CHC) infection who failed to have a sustained virologic response to initial therapy. The authors examined the effects of weight-related conditions on disease outcomes, and demonstrated that insulin resistance, the presence of Mallory bodies, as well as weight change between baseline and 1 year after randomization were associated with outcomes of CHC patients, implying that improvement in weight-related factors might modify disease progression. Alt... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229071 Mon, 21 Dec 2009 00:00:00 +0100 3229071 Gastrointestinal Cancer Atlas for Endoscopic Therapy http://www.medworm.com/index.php?rid=3229070&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509021854%2Fabstract%3Frss%3Dyes Early diagnosis of cancer is the key to cure. With small ( (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229070 Mon, 21 Dec 2009 00:00:00 +0100 3229070 Understanding the Irritable Gut http://www.medworm.com/index.php?rid=3229069&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509021842%2Fabstract%3Frss%3Dyes The functional gastrointestinal disorders (FGIDs) encompass a diverse group of conditions that are defined by the presence of characteristic symptoms. Because no reliable or reproducible biomarkers are currently available, these disorders are defined on the basis of symptom clusters. The Rome Foundation is an “independent not for profit organization that provides support for activities designed to create scientific data and educational information to assist in the diagnosis and treatment of functional gastrointestinal disorders.” (http://www.romecriteria.org/about/). The stated mission of the Rome Foundation is to “improve the lives of people with functional GI disorders.” The Rome Foundation has provided leadership and direction in the development of diagnostic criteria for the va... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229069 Mon, 21 Dec 2009 00:00:00 +0100 3229069 Probiotics in Pediatric Medicine http://www.medworm.com/index.php?rid=3229068&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509021830%2Fabstract%3Frss%3Dyes If you Google “probiotics,” you get >2 million hits; PubMed yields >5000 scientific articles on the topic; and both Time and Newsweek ran pieces on probiotics and gut flora in 2008. Lots of patients take probiotics, lots of physicians recommend probiotics for the management of various gastrointestinal symptoms, and more and more companies are marketing probiotic foods and supplements. Despite all this intense interest in the field of probiotics and gut health, it can be challenging for the clinician to find an unbiased, evidence-based, and comprehensive evaluation of probiotics. Probiotics in Pediatric Medicine, a 352-page, 24-chapter, multi-author book, fills this role quite nicely, providing an excellent, thorough, and complete reference text focused on the normal physiology of gut m... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229068 Mon, 21 Dec 2009 00:00:00 +0100 3229068 Reply http://www.medworm.com/index.php?rid=3229067&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509021805%2Fabstract%3Frss%3Dyes We appreciated the Selected Summary entitled “Are IgG4-positive multiorgan lymphoproliferative syndrome and autoimmune pancreatitis different manifestations of a common clinicopathological entity?” by Dr Chiba. As Dr Chiba mentioned, our concept of IgG4-positive multiorgan lymphoproliferative syndrome (IgG4+MOLPS; Ann Rheum Dis 2009;68:1310–1315) shares many similar clinical features and laboratory findings observed in AIP (J Gastoenterol 2008;43:409–418), especially in LPSP (Am J Dig Dis 1961;6:688–698). In general, we agree with Dr Chiba that IgG4+MOLPS and AIP are the same disease entity, although several differences in histopathologic features and frequencies of affected organs still exist between the 2 diseases. Beside “IgG4+MOLPS,” there are many synonyms, such as multi... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229067 Mon, 21 Dec 2009 00:00:00 +0100 3229067 Are Immunoglobulin G4-Positive Multiorgan Lymphoproliferative Syndrome and Autoimmune Pancreatitis Different Manifestations of a Common Clinicopathologic Entity? http://www.medworm.com/index.php?rid=3229066&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509021581%2Fabstract%3Frss%3Dyes Masaki Y, Dong L, Kurose N, et al. (Department of Hematology and Immunology, Kanazawa Medical University, Ishikawa, Japan). Proposal for a new clinical entity, IgG4-positive multiorgan lymphoproliferative syndrome: analysis of 64 cases of IgG4-related disorders. Ann Rheum Dis 2009;68:1310–1315. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229066 Mon, 21 Dec 2009 00:00:00 +0100 3229066 Reply http://www.medworm.com/index.php?rid=3229065&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509021829%2Fabstract%3Frss%3Dyes We appreciate the interest that our work has generated. We would like to thank Professors Watson and Duckworth for raising the relevant question whether other mechanisms and/or tight junction proteins are involved in the control of the gut permeability through the gut microbiota and endogenous GLP-2 production. We would like to specifically focus our response on the following comment: “Further studies are warranted to determine whether the observed changes in barrier function are mediated by occludin and/or ZO-1 alone or in combination with other tight junction associated molecules such as the claudins and JAMs, and whether these other molecules are implicated in barrier response to GLP-2 with occludin and ZO-1 having bystander roles only.” (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229065 Mon, 21 Dec 2009 00:00:00 +0100 3229065 Gut Microbiota Control Gut Permeability Through GLP-2 http://www.medworm.com/index.php?rid=3229064&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509021593%2Fabstract%3Frss%3Dyes Cani PD, Possemiers S, Van de Wiele T, et al. (Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Louvain Drug Research Unit, Université catholique de Louvain, Brussels, Belgium). Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. Gut 2009;58:1091–1103. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229064 Mon, 21 Dec 2009 00:00:00 +0100 3229064 Failure of Interferon to Prevent Disease Progression and Liver Cancer in Hepatitis C Virus Infection: Proof of Absence or Absence of Proof? http://www.medworm.com/index.php?rid=3229063&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS001650850902160X%2Fabstract%3Frss%3Dyes Di Bisceglie AM, Shiffman ML, Everson GT, et al, HALT-C trial investigators. (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, Missouri). Prolonged therapy of advanced chronic hepatitis C with low-dose peginterferon. N Engl J Med 2008;359:2429–2441. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229063 Mon, 21 Dec 2009 00:00:00 +0100 3229063 Reply http://www.medworm.com/index.php?rid=3229062&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509021726%2Fabstract%3Frss%3Dyes I am very grateful to Dr Gerson for drawing attention to our recent systematic review and meta-analysis (Gut 2009;58:367–378). This was the first published study to conclude that antidepressants were effective as primary therapy for the treatment of irritable bowel syndrome (IBS). A previous systematic review and meta-analysis had examined this issue (Cochrane Database Syst Rev 2005;2:CD003460). However, errors in its conduct, including failure to identify published eligible studies available at the time the review was conducted, inclusion of ineligible studies, and errors in dichotomous data extraction, led the authors to erroneously conclude that these drugs were of no benefit for treatment of patients who had IBS (Am J Gastroenterol 2009;doi:10.1038/ajg.2009.658). A limitation of some... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229062 Mon, 21 Dec 2009 00:00:00 +0100 3229062 Antidepressants for Irritable Bowel Syndrome: Reappraisal for the Nondepressed http://www.medworm.com/index.php?rid=3229061&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS001650850902157X%2Fabstract%3Frss%3Dyes Ford AC, Talley NJ, Schoenfeld PS, et al. (Gastroenterology Division, McMaster University, Ontario, Canada; Department of Medicine, Mayo Clinic, Jacksonville, Florida; Division of Gastroenterology, University of Michigan School of Medicine, Ann Arbor, Michigan; Department of Medicine, Cork University Hospital, Cork, Ireland). Efficacy of antidepressants and psychological therapies in irritable bowel syndrome: systematic review and meta-analysis. Gut 2009;58:367–378. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229061 Mon, 21 Dec 2009 00:00:00 +0100 3229061 February CME Exam 2 Questions http://www.medworm.com/index.php?rid=3229057&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509021878%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229057 Mon, 21 Dec 2009 00:00:00 +0100 3229057 February CME Exam 1 Questions http://www.medworm.com/index.php?rid=3229056&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509021866%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229056 Mon, 21 Dec 2009 00:00:00 +0100 3229056 Esophageal Blebs and Blisters http://www.medworm.com/index.php?rid=3229024&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509011354%2Fabstract%3Frss%3Dyes Question: A 65-year-old man was admitted because of dysphagia and coffee-ground emesis of 2 days duration. His past medical history was remarkable for end-stage renal disease, peripheral vascular disease, coronary artery disease, pemphigoid, and pulmonary embolism. On physical examination, he appeared chronically ill but nontoxic. The skin had multiple erythematous patches and small, fluid-filled blebs on both hands and feet. Abnormal laboratory data included: hemoglobin of 6.1 mmol/L (normal range, 7.4–10.0), hematocrit of 0.31 (normal range, 0.35–0.47), mean corpuscular volume of 84 (normal range, 80–95), International Normalized Ratio 2.67, and C-reactive protein of 67.2 (normal, (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229024 Mon, 21 Dec 2009 00:00:00 +0100 3229024 Recurrent Nausea, Vomiting, and Abdominal Pain http://www.medworm.com/index.php?rid=3229023&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509009330%2Fabstract%3Frss%3Dyes Question: A 34-year-old woman presented with recurrent nausea, vomiting, and abdominal pain over a 6-month period. She denied respiratory or cutaneous symptoms. Her past medical history was significant for a history of hypertension, gastroesophageal reflux, and melanoma, which was resected from her left thigh 3 years ago. Lymph node dissection at the time was negative. During these episodes, she was afebrile and had a normal serum white blood cell count, electrolytes, and liver function tests. Complement and C1 esterase inhibitor levels were normal. However, her C-reactive protein was elevated. Her medications included lisinopril, hydrochlorothiazide, Protonix, an oral contraceptive, iron, and occasional nonsteroidal anti-inflammatory drugs. For each episode, she was admitted to the hospit... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229023 Mon, 21 Dec 2009 00:00:00 +0100 3229023 Optical Molecular Imaging Approaches in Colorectal Cancer http://www.medworm.com/index.php?rid=3229018&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509021568%2Fabstract%3Frss%3Dyes See “In vivo molecular imaging of colorectal cancer with confocal endomicroscopy by targeting epidermal growth factor receptor,” by Goetz M, Ziebart A, Foersch S, et al, on page 435. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229018 Mon, 21 Dec 2009 00:00:00 +0100 3229018 This Month in Gastroenterology http://www.medworm.com/index.php?rid=3229011&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509021945%2Fabstract%3Frss%3Dyes Whipple's disease is a rare inflammatory disorder caused by infection of different organ systems with Tropheryma whipplei. In the gastrointestinal tract, jejunal infection with T whipplei causes diarrhea or steatorrhea with weight loss. Treatment with a combination of doxycycline, hydroxychloroquine, and sulfamethoxazole or sulfadiazine is usually recommended, but prospective data assessing the efficacy of these antibiotics are lacking. Moreover, retrospective case series report failure rates of up to 30% using these antibiotic regimens. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229011 Mon, 21 Dec 2009 00:00:00 +0100 3229011 Pancreatic Duct Glands Are Distinct Ductal Compartments That React to Chronic Injury and Mediate Shh-Induced Metaplasia http://www.medworm.com/index.php?rid=3324401&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509021192%2Fabstract%3Frss%3Dyes Conclusions: PDG are distinct gland-like mucinous compartments with a distinct molecular signature. In response to injury, PDG undergo an Shh-mediated mucinous gastrointestinal metaplasia with PanIN-like features. PDG may provide a link between Shh, mucinous metaplasia, and neoplasia. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324401 Fri, 18 Dec 2009 00:00:00 +0100 3324401 State of Research in Pediatric Gastroenterology, Hepatology, and Nutrition: 2010 and Beyond http://www.medworm.com/index.php?rid=3229016&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509021957%2Fabstract%3Frss%3Dyes This is the second update for the state of research in pediatric gastroenterology, hepatology, and nutrition for Gastroenterology. It is commonly accepted among clinical gastroenterologists that this subspecialty requires a comprehensive knowledge of diseases crossing all age groups to provide appropriate care for their patients. Many gastrointestinal conditions that are present during childhood also require long-term care as chronic diseases extending into adulthood. The classic example is inflammatory bowel disease (IBD), particularly Crohn's disease (CD), which is occurring with increasing frequency in developed countries during childhood but, despite improved treatment, requires ongoing care well into adulthood. Identification of polymorphisms in receptors and signaling molecules for t... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229016 Thu, 17 Dec 2009 00:00:00 +0100 3229016 New Appointments to the Board of Editors http://www.medworm.com/index.php?rid=3229015&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509021908%2Fabstract%3Frss%3Dyes Pankaj Jay Pasricha, MD, and Ralf Kiesslich, MD, PhD, have joined the Gastroenterology Board of Editors, effective November 2009. Dr Pasricha will serve as an Associate Editor for manuscripts related to imaging and technology, and will assist in the areas of pancreatology and enteric neurobiology. He will also share co-editorship of the “Imaging and Advanced Technology” section with Dr Kiesslich. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229015 Thu, 17 Dec 2009 00:00:00 +0100 3229015 Sustained Virologic Response to Hepatitis C Virus Therapy and Spontaneous Viral Clearance Found Linked to Genotype http://www.medworm.com/index.php?rid=3229014&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509021921%2Fabstract%3Frss%3Dyes A pair of papers in the journal Nature offer strong evidence that genotype dictates sustained virologic response (SVR) to hepatitis C therapy and is also associated with spontaneous viral clearance. A paper published is September 2009 involved a genome-wide association study of >1600 individuals chronically infected with hepatitis C participating in the IDEAL clinical treatment trial. The study compared the effectiveness of three treatment regimens involving pegylated interferon (PegIFN)-a-2b or PegIFN-a-2a combined with ribavirin (RBV). Patients received 48 weeks of treatment and 24 weeks of follow-up. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229014 Thu, 17 Dec 2009 00:00:00 +0100 3229014 GINA, Imperfect But Official http://www.medworm.com/index.php?rid=3229013&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS001650850902191X%2Fabstract%3Frss%3Dyes On November 21, 2009, 18 months after President Bush signed it into law, the Genetic Information Nondiscrimination Act of 2008 became officially effective. Also known as GINA, the law prohibits employer discrimination based on genetic information and also prohibits health insurers from denying coverage or setting rates based on a person's genetic makeup, such as a predisposition to a disease. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229013 Thu, 17 Dec 2009 00:00:00 +0100 3229013 More Than $500 Million Spent for Lobbying by Health Care Interest Groups in 2009 http://www.medworm.com/index.php?rid=3229012&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509021933%2Fabstract%3Frss%3Dyes The health care sector and the insurance industry will have likely set a record for annual lobbying expenditures—more than a half of a billion dollars—in 2009. The health sector includes health care professionals (including physicians and nurses), pharmaceutical and health care products companies, hospitals and nursing homes, health services, and health maintenance organizations. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229012 Thu, 17 Dec 2009 00:00:00 +0100 3229012 Resistance to Direct Antiviral Agents in Patients With Hepatitis C Virus Infection http://www.medworm.com/index.php?rid=3229028&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509021131%2Fabstract%3Frss%3Dyes Chronic hepatitis C virus (HCV) infection is one of the major causes of cirrhosis, hepatocellular carcinoma, and liver failure that leads to transplantation. The current standard treatment, a combination of pegylated interferon alfa and ribavirin, eradicates the virus in only about 50% of patients. Directly acting antiviral (DAA) agents, which inhibit HCV replication, are in phase 1, 2, and 3 trials; these include reagents that target the nonstructural (NS)3 protease, the NS5A protein, the RNA-dependent RNA-polymerase NS5B, as well as compounds that directly inhibit HCV replication through interaction with host cell proteins. Because of the high genetic heterogeneity of HCV and its rapid replication, monotherapy with DAA agents poses a high risk for selection of resistant variants. We revi... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3229028 Mon, 14 Dec 2009 00:00:00 +0100 3229028 Silibinin and Related Compounds Are Direct Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase http://www.medworm.com/index.php?rid=3324396&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509021052%2Fabstract%3Frss%3Dyes Conclusions: Silibinin A and silibinin B, as well as Legalon SIL, inhibit HCV replicon and JFH1 replication in cell culture. This effect is at least partly explained by the ability of these compounds to inhibit HCV RNA-dependent RNA polymerase activity. Our results provide a basis for the optimization and subsequent development of members of the Flavonoid family as specific HCV antivirals. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324396 Mon, 07 Dec 2009 00:00:00 +0100 3324396 Conditional Deletion of IκB-Kinase-β Accelerates Helicobacter-Dependent Gastric Apoptosis, Proliferation, and Preneoplasia http://www.medworm.com/index.php?rid=3324388&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509021088%2Fabstract%3Frss%3Dyes Conclusions: The loss of IKKβ/NF-κB signaling in GECs results in increased apoptosis and necrosis in response to cellular stress, and accelerated development of dysplasia by Helicobacter infection. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324388 Mon, 07 Dec 2009 00:00:00 +0100 3324388 Immortalized Epithelial Cells Derived From Human Colon Biopsies Express Stem Cell Markers and Differentiate In Vitro http://www.medworm.com/index.php?rid=3324387&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509021040%2Fabstract%3Frss%3Dyes Conclusions: We established immortalized HCECs that are capable of self-renewal and multilineage differentiation. These cells should serve as valuable reagents for studying colon stem cell biology, differentiation, and pathogenesis. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324387 Mon, 07 Dec 2009 00:00:00 +0100 3324387 Stat3 Is a Negative Regulator of Intestinal Tumor Progression in ApcMin Mice http://www.medworm.com/index.php?rid=3324386&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509021015%2Fabstract%3Frss%3Dyes Conclusions: Our data suggest that Stat3 impairs invasiveness of intestinal tumors. Therefore, therapeutic targeting of the Stat3 signaling pathway in intestinal cancer should be evaluated for adverse effects on tumor progression. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324386 Mon, 07 Dec 2009 00:00:00 +0100 3324386 Effect of Puberty Onset on Spontaneous Hepatitis B Virus e Antigen Seroconversion in Men http://www.medworm.com/index.php?rid=3324380&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509021039%2Fabstract%3Frss%3Dyes This study elucidated the effects of puberty on spontaneous hepatitis B virus e antigen (HBeAg) seroconversion in boys.Methods: One-hundred HBeAg-positive chronic HBV-infected males recruited at younger than 10 years of age who had been followed for >10 years were selected randomly from our long-term followed cohort into this study. Serum testosterone levels, androgen receptor exon-1 CAG repeat number and steroid 5α reductase type II (SRD5A2, valine vs leucine alleles) polymorphism were determined. Serial clinical data, HBV genotype, and spontaneous HBeAg seroconversion age were also analyzed.Results: Seventy-two subjects had spontaneous HBeAg seroconversion during the follow-up period. Subjects with serum testosterone levels ≥2.5 ng/mL at 15 years old (earlier-onset puberty, n = 87) ha... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324380 Mon, 07 Dec 2009 00:00:00 +0100 3324380 Chronic Hepatitis C Is Associated With Peripheral Rather Than Hepatic Insulin Resistance http://www.medworm.com/index.php?rid=3324379&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509021027%2Fabstract%3Frss%3Dyes Conclusions: CHC represents a unique infective/inflammatory model of IR, which is predominantly in muscle, correlates with subcutaneous, not visceral, adiposity, and is independent of liver fat. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324379 Mon, 07 Dec 2009 00:00:00 +0100 3324379 Copyright Assignment, Authorship Responsibility, NIH Funding, Financial Disclosure, Institutional Review Board/Animal Care Committee Approval, and Sponsorship http://www.medworm.com/index.php?rid=3058295&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509018964%2Fabstract%3Frss%3Dyes Copyright Assignment. In consideration of the American Gastroenterological Association (AGA) Institute (the “AGA Institute”) taking action to review and credit the below-identified submission (the “Manuscript”), and for other valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned authors and/or creators (the “Authors”), jointly and severally, hereby transfer, convey, and assign to the AGA Institute, free and clear of any liens, licenses or encumbrances, the entire right, title, and interest in and to the Manuscript throughout the world, including without limitation in and to any and all copyrights for the Manuscript (including but not limited to rights to copy, publish, excerpt, collect royalties and make derivative works) in print,... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3058295 Tue, 01 Dec 2009 00:00:00 +0100 3058295 Forthcoming Articles 4 http://www.medworm.com/index.php?rid=3058294&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509018952%2Fabstract%3Frss%3Dyes Hepatitis C Virus Core Protein Subverts the Anti-Viral Activities of Human Kupffer Cells Zhengkun Tu, Robert H. Pierce, Jonathan Kurtis, Yoshio Kuroki, I. Nicholas Crispe, and Mark S. Orloff (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3058294 Tue, 01 Dec 2009 00:00:00 +0100 3058294 Forthcoming Articles 3 http://www.medworm.com/index.php?rid=3058293&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509018940%2Fabstract%3Frss%3Dyes Impaired Immune Functions of Monocytes and Macrophages in Whipple's Disease Verena Moos, Carsten Schmidt, Anika Geelhaar, Désirée Kunkel, Kristina Allers, Katina Schinnerling, Christoph Loddenkemper, Florence Fenollar, Annette Moter, Didier Raoult, Ralf Ignatius, and Thomas Schneider (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3058293 Tue, 01 Dec 2009 00:00:00 +0100 3058293 Forthcoming Articles 2 http://www.medworm.com/index.php?rid=3058292&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509018939%2Fabstract%3Frss%3Dyes Effective Treatment Of Injecting Drug Users With Recently Acquired Hepatitis C Virus Infection G.J. Dore, M. Hellard, G. Matthews, J. Grebely, P.S. Haber, K. Petoumenos, B. Yeung, P. Marks, I. van Beek, G. McCaughan, P. White, R. French, W. Rawlinson, A.R. Lloyd, J.M. Kaldor, and the ATAHC Study Group (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3058292 Tue, 01 Dec 2009 00:00:00 +0100 3058292 Forthcoming Articles 1 http://www.medworm.com/index.php?rid=3058291&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509018927%2Fabstract%3Frss%3Dyes Radioembolization for hepatocellular carcinoma using Yttrium-90 microspheres: a comprehensive report of long-term outcomes Riad Salem, Robert J Lewandowski, Mary F Mulcahy, Ahsun Riaz, Robert K Ryu, Saad Ibrahim, Bassel Atassi, Talia Baker, Vanessa Gates, Frank H Miller, Kent T Sato, Ed Wang, Ramona Gupta, Al B Benson, Steven B Newman, Reed A Omary, Michael Abecassis and Laura Kulik (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3058291 Tue, 01 Dec 2009 00:00:00 +0100 3058291 Information for Authors and Readers http://www.medworm.com/index.php?rid=3058290&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509018915%2Fabstract%3Frss%3Dyes Gastroenterology is the premiere journal in the field of gastrointestinal disease and is led by an internationally renowned board of editors. As the official journal of the AGA Institute, Gastroenterology delivers up-to-date and authoritative coverage of both basic and clinical gastroenterology and hepatology. Regular features include research and perspectives by leading authorities, reports on the latest technologies for diagnosing and treating digestive diseases, images illustrating important clinical findings, reviews of scholarly media, medical news, meeting summaries, video abstracts, and monthly podcasts. Gastroenterology also bridges the gap between basic and clinical science by publishing comprehensive reviews on important topics such as pancreatitis and liver disease. (Source: Gas... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3058290 Tue, 01 Dec 2009 00:00:00 +0100 3058290 Table of Contents http://www.medworm.com/index.php?rid=3058289&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509018903%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3058289 Tue, 01 Dec 2009 00:00:00 +0100 3058289 Editorial Board http://www.medworm.com/index.php?rid=3058288&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509018897%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3058288 Tue, 01 Dec 2009 00:00:00 +0100 3058288 Subject Index to Volume 137 http://www.medworm.com/index.php?rid=3058287&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509019337%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3058287 Tue, 01 Dec 2009 00:00:00 +0100 3058287 Author Index to Volume 137 http://www.medworm.com/index.php?rid=3058286&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509019325%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3058286 Tue, 01 Dec 2009 00:00:00 +0100 3058286 Information for Authors http://www.medworm.com/index.php?rid=3058285&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509019313%2Fabstract%3Frss%3Dyes Gastroenterology publishes clinical and basic studies of all aspects of the digestive system, including the liver and pancreas, as well as nutrition. The types of articles Gastroenterology publishes include original papers, review articles, and special category manuscripts. Manuscripts must be prepared in accordance with the “Uniform Requirements for Manuscripts Submitted to Biomedical Journals” developed by the International Committee of Medical Journal Editors (http://www.icmje.org). Gastroenterology is a member of the Committee on Publication Ethics (COPE) (http://www.publicationethics.org.uk). (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3058285 Tue, 01 Dec 2009 00:00:00 +0100 3058285 Position Statement: Nonanesthesiologist Administration of Propofol for GI Endoscopy http://www.medworm.com/index.php?rid=3058271&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509017454%2Fabstract%3Frss%3Dyes This statement on the use of nonanesthesiologist-administered propofol (NAAP) for GI endoscopy is issued jointly by The American Association for the Study of Liver Diseases, American College of Gastroenterology, American Gastroenterological Association, and American Society for Gastrointestinal Endoscopy. A 4-member committee, composed of a representative from each society, prepared the first draft of this document, which was then reviewed and approved by the governing board of each organization. This document is designed to provide an evidence-based assessment of propofol-mediated sedation by properly trained gastroenterologists and other nonanesthesiologists. The safety, efficacy, cost-effectiveness, and training issues involved with nonanesthesiologist administration of propofol for GI ... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3058271 Tue, 01 Dec 2009 00:00:00 +0100 3058271 Cover 1 http://www.medworm.com/index.php?rid=3058222&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509018873%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3058222 Tue, 01 Dec 2009 00:00:00 +0100 3058222 Hepatitis C Virus Infection Reduces Hepatocellular Polarity in a Vascular Endothelial Growth Factor–Dependent Manner http://www.medworm.com/index.php?rid=3324398&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509020976%2Fabstract%3Frss%3Dyes Conclusions: Hepatic polarity is critical to normal liver physiology. HCV infection promotes VEGF expression that depolarizes hepatoma cells, promoting viral transmission and lymphocyte migration into the parenchyma that may promote hepatocyte injury. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324398 Mon, 30 Nov 2009 00:00:00 +0100 3324398 Genome-Wide Association Analysis in Primary Sclerosing Cholangitis http://www.medworm.com/index.php?rid=3324395&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509020630%2Fabstract%3Frss%3Dyes Conclusions: Strong HLA associations and a subset of genes involved in bile homeostasis and other inflammatory conditions constitute key components of the genetic architecture of PSC. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324395 Mon, 30 Nov 2009 00:00:00 +0100 3324395 Unusual Case of Right Upper Quadrant Swelling http://www.medworm.com/index.php?rid=3121387&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509018800%2Fabstract%3Frss%3Dyes Question: An 87-year-old woman presented to the emergency department with a 2-month history of pain and swelling over the right upper quadrant of her abdomen. She was otherwise fit and well. She was afebrile and hemodynamically stable. On examination, the abdomen was soft and nontender. A 5cm × 5cm tense, tender, fluctuant swelling with surrounding erythema was palpable in the right hypochondrium (, arrow). Full blood count, renal, and liver functions were within normal limits. She received an ultrasound of her abdomen which revealed the swelling to be in the subcutaneous plane. The abscess was subsequently incised and drained under local anaesthetic. She underwent a computed tomography scan () of the abdomen, post drainage, due to the nature of contents in the abscess cavity. (Source: Ga... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121387 Mon, 30 Nov 2009 00:00:00 +0100 3121387 Underrepresentation of Underrepresented Minorities in Academic Medicine: The Need to Enhance the Pipeline and the Pipe http://www.medworm.com/index.php?rid=3121380&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509020344%2Fabstract%3Frss%3Dyes The number of underrepresented minorities (URMs; black or African American, Hispanic or Latino, American Indian or Alaska Native, Native Hawaiian or other Pacific Islander) among US medical school faculty is markedly low when compared with their respective percent representation of the US population. Women URMs are doubly underrepresented, particularly as the academic rank advances from the instructor to the professor level, and gender discrepancies occur more prominently among white female faculty. Although the percent of white faculty has decreased over the past 5 years, the low percentage of black and Hispanic faculty has not changed proportionately. Furthermore, the 2008–2009 pipeline of URM trainees is unlikely to reverse the current trends. Several measures are suggested for consid... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121380 Mon, 30 Nov 2009 00:00:00 +0100 3121380 This Month in Gastroenterology http://www.medworm.com/index.php?rid=3121373&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509020563%2Fabstract%3Frss%3Dyes The use of low-dose aspirin in the prevention of cardiovascular disease is frequently associated with the development of dyspeptic symptoms and erosions or ulcerations in the upper gastrointestinal tract. Eradication of Helicobacter pylori and long-term maintenance therapy with proton pump inhibitors (PPI) are effective in the prevention of aspirin-induced gastrointestinal lesions and symptoms in patients with a history of aspirin-induced erosions or peptic ulcer. The potential role of H2-receptor antagonists after healing of aspirin induced peptic ulcer or erosions is unclear. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121373 Fri, 27 Nov 2009 00:00:00 +0100 3121373 Population-Based Family History–Specific Risks for Colorectal Cancer: A Constellation Approach http://www.medworm.com/index.php?rid=3324373&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509020617%2Fabstract%3Frss%3Dyes Conclusions: Increased numbers of affected FDRs influences risk much more than affected SDRs or TDRs. However, when combined with a positive first-degree family history, a positive second- and third-degree family history can significantly increase risk. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3324373 Mon, 23 Nov 2009 00:00:00 +0100 3324373 Reply http://www.medworm.com/index.php?rid=3121439&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509020368%2Fabstract%3Frss%3Dyes I commend Dr Matuchansky for further elucidation of the important issues surrounding flat lesions, including nonpolypoid colorectal neoplasms, and their detection by CTC. To be sure, there is great controversy about these lesions, particularly related to their detection by all currently available colon imaging modalities. My own view is that, because of the controversy and uncertainties surrounding these lesions, more investigation about them is needed—including clarification of their natural history, diagnostic detection rate with available tests, and, of course, appropriate management. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121439 Mon, 23 Nov 2009 00:00:00 +0100 3121439 Computed Tomographic Colonography Accuracy: Nonpolypoid Neoplasms http://www.medworm.com/index.php?rid=3121438&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509019556%2Fabstract%3Frss%3Dyes I read with great interest the article by Dr Rockey, in the July 2009 issue of Gastroenterology, regarding current perspectives and future directions of computed tomographic colonography (CTC). He rightly stated that many issues concerning CTC remain, and are quoted among topics of paramount importance accuracy and implementation of the technique. But, except for a few words in the implementation section “More work in this area is clearly required. This is especially the case for flat lesions … where size alone may not be the key determinant of neoplastic risk,” the author did not refer, especially in the accuracy section, to the diagnostic problems raised by nonpolypoid (ie, flat, with a height of less than half of the lesion diameter, or depressed, with a base that is lower than th... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121438 Mon, 23 Nov 2009 00:00:00 +0100 3121438 Alpha-Fetoprotein in Early Hepatocellular Carcinoma http://www.medworm.com/index.php?rid=3121437&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509019568%2Fabstract%3Frss%3Dyes We read with interest the Editorial comments from Forner et al about our recent article. We disagree with some of the comments about the utility of alpha-fetoprotein (AFP) in surveillance for hepatocellular carcinoma (HCC) and about surveillance in general. We, herein, address the points raised in the Editorial. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121437 Mon, 23 Nov 2009 00:00:00 +0100 3121437 http://www.medworm.com/index.php?rid=3121436&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509020599%2Fabstract%3Frss%3Dyes Reading Complicated Cases in GI (edited by Kalloo and Buscaglia, with contributions from multiple fellows past and present) will prompt a rush of fellowship memories for most gastroenterologists. This hardbound book is a collection of 59 cases that have been presented at The Johns Hopkins GI Grand Rounds between 2003 and 2007. It doesn't take long to recall the scene: the harried first-year fellow who has scurried to find the perfect case (with supporting laboratory values and imaging studies) and to prepare a brief but comprehensive review (usually late the night before); the confident, seasoned older fellows excited, but secretly terrified to be singled out to discuss the patient; attending physicians vying to seem omniscient—you remember it. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121436 Mon, 23 Nov 2009 00:00:00 +0100 3121436 http://www.medworm.com/index.php?rid=3121435&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509020587%2Fabstract%3Frss%3Dyes This text has the stated purpose of providing staging and grading information because it is “indispensable when analyzing disease severity, therapeutic outcomes, or quality of life in a systematic reproducible fashion.” Accurate staging and grading of disease pathology is of vital importance in any field of medicine, but especially so in the field of gastroenterology with its myriad of clinical manifestations, rapid evolution, and sometimes exotic pathology. It is often difficult for investigators to be aware of the different systems that have been used and even more difficult to compare studies without this standardization of grading and assessment tools. Provided with this unique opportunity of fulfilling an as yet unmet need, Tytgat and Tytgat have put together a thorough compendium... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121435 Mon, 23 Nov 2009 00:00:00 +0100 3121435 http://www.medworm.com/index.php?rid=3121434&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509020575%2Fabstract%3Frss%3Dyes Pancreatic Cancer, edited by Lowy, Leach, and Philip, is an important volume in the M.D. Anderson Solid Tumor Oncology Series. The book details the significant developments in the field of pancreatic cancer research, diagnosis, and treatment that have occurred in the last 5 years, and places this information in the context of what is already known about pancreatic cancer. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121434 Mon, 23 Nov 2009 00:00:00 +0100 3121434 Novel Insights Into the Association Between HLA-DP Variants and Persistent Hepatitis B Virus Infection: A Genome-wide Association Study http://www.medworm.com/index.php?rid=3121433&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509020472%2Fabstract%3Frss%3Dyes Kamatani Y, Wattanapokayakit S, Ochi H, et al. (Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, the University of Tokyo, Tokyo, Japan). A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians. Nature Genetics 2009;41:591–595. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121433 Mon, 23 Nov 2009 00:00:00 +0100 3121433 Of Blemishes and Bowels: Isotretinoin and Inflammatory Bowel Disease http://www.medworm.com/index.php?rid=3121432&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509020460%2Fabstract%3Frss%3Dyes Bernstein CN, Nugent Z, Longobardi T, Blanchard JF. (University of Manitoba IBD Clinical and Research Centre, Winnipeg, Manitoba, Canada). Isotretinoin is not associated with inflammatory bowel disease: a population-based case-control study. Am J Gastroenterol 2009;104:2774–2778. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121432 Mon, 23 Nov 2009 00:00:00 +0100 3121432 Reply http://www.medworm.com/index.php?rid=3121431&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509020459%2Fabstract%3Frss%3Dyes We thank Dr Triadafilopoulos for his accurate and positive comments on our study. We agree with his critique that our study has limitations; notably in terms of short term follow-up, absence of a medical control group, and nongeneralizability of these data to the general community setting. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121431 Mon, 23 Nov 2009 00:00:00 +0100 3121431 A Closure Without a Closure: Impedance pH Monitoring Expanding the Indications for Antireflux Surgery http://www.medworm.com/index.php?rid=3121430&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509020447%2Fabstract%3Frss%3Dyes DelGenio G, Tolone S, DelGenio F, et al. Prospective assessment of patient selection for antireflux surgery by combined multichannel intraluminal impedance pH monitoring. J Gastrointest Surg 2008;12:1491–1496. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121430 Mon, 23 Nov 2009 00:00:00 +0100 3121430 Reply http://www.medworm.com/index.php?rid=3121429&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509020435%2Fabstract%3Frss%3Dyes We thank Professors Aghemo and Colombo for their comprehensive review and discussion of the IDEAL trial and appreciate the opportunity provided by the editors of gastroenterology to provide additional discussion. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121429 Mon, 23 Nov 2009 00:00:00 +0100 3121429 Peginterferon Alfa-2B Versus Peginterferon Alfa-2A With Ribavirin for the Treatment of Chronic Hepatitis C: The Pursuit of an Ideal http://www.medworm.com/index.php?rid=3121428&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509020423%2Fabstract%3Frss%3Dyes McHutchison JG, Lawitz EJ, Shiffman ML, et al. Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection. N Engl J Med 2009;361:580–593. Treatment of chronic hepatitis C is aimed at persistent eradication of hepatitis C virus (HCV), an end point that can drastically modify the natural progressive course of the disease (Hepatology 2002;36:S35–S46). Indeed, once achieved, a sustained virologic response (SVR) can benefit both the patients with chronic hepatitis, by preventing progression to cirrhosis (Gastroenterology 2002;122:1303–1313), as those with established cirrhosis as it can reduce the risk of hepatic decompensation and hepatocellular carcinoma (Hepatology 2007;45:579–587). The latest innovation in anti-HCV treatment has been the development of p... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121428 Mon, 23 Nov 2009 00:00:00 +0100 3121428 January CME Exam 2 Questions http://www.medworm.com/index.php?rid=3121427&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS001650850902054X%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121427 Mon, 23 Nov 2009 00:00:00 +0100 3121427 January CME Exam 1 Questions http://www.medworm.com/index.php?rid=3121426&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509020538%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121426 Mon, 23 Nov 2009 00:00:00 +0100 3121426 Right Cardiophrenic Angle Mass http://www.medworm.com/index.php?rid=3121392&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509008646%2Fabstract%3Frss%3Dyes Question: A 51-year-old woman underwent routine chest radiography. Posterior-anterior chest radiography showed a smooth, well-circumscribed soft tissue density mass in the right cardiophrenic angle that measured 5 cm in diameter and rendered the right cardiophrenic angle opaque (, arrow). The lateral view identified the anterior position of the mass (, arrow). (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121392 Mon, 23 Nov 2009 00:00:00 +0100 3121392 The Importance of Unfettered Gastric Motility http://www.medworm.com/index.php?rid=3121391&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509011330%2Fabstract%3Frss%3Dyes Question: A 46-year-old woman presented with a 3-week history of worsening dyspnea on exertion. Her past medical history was significant for poorly controlled type 2 diabetes with prior treatment for gastroparesis and iron-deficiency anemia. Pertinent medications included metformin, daily aspirin, esomeprazole, and iron supplementation. Physical examination revealed a pale woman in no acute distress. Her abdomen was soft without tenderness to palpation. Rectal examination revealed melena. Laboratory results showed severe anemia with a hemoglobin of 5.3 g/dL and a hematocrit of 18.2%. The iron profile revealed an iron of 46 μg/dL, and transferrin saturation of 11.7%. The patient was stabilized with IV fluid hydration and IV proton pump inhibitor; she was given 2 units of packed red blood c... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121391 Mon, 23 Nov 2009 00:00:00 +0100 3121391 Persistent Left Lower Abdominal Pain http://www.medworm.com/index.php?rid=3121390&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509008634%2Fabstract%3Frss%3Dyes Question: A 56-year-old man presented for new onset abdominal pain. His past medical history was significant for bilateral inguinal hernia repair and appendectomy in 1997. In 2004, he was evaluated for recurrent hematochezia and a flexible sigmoidoscopy at that time revealed internal hemorrhoids. Three months before this presentation, he began to complain of colicky abdominal pain, localized to the left lower quadrant and suprapubic area. The pain was increased by food intake and was not associated with any other symptoms. The physical examination and laboratory findings were normal. Abdominal and pelvic computed tomography (CT; A) showed, in addition to the extensive sigmoid diverticulosis, mild streaking with possible air-pocket containing collection in continuity with the sigmoid colon ... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121390 Mon, 23 Nov 2009 00:00:00 +0100 3121390 Preventing an Unfortunate Polypectomy Attempt in a Large Broad-Based, Smooth, and Soft Polypoid Elevation of the Colonic Wall http://www.medworm.com/index.php?rid=3121389&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509008609%2Fabstract%3Frss%3Dyes Question: A 65-year-old black man with a medical history significant for hypertension and hemorrhoids was referred by his primary care doctor for colorectal cancer screening. The patient denies constipation and notes a small amount of blood on the toilet paper. Also the patient denies any abdominal pain or weight loss. The patient has no family history of colon cancer. Medication list significant for lisinopril 40 mg once a day and ibuprofen 800 mg tablet as needed. Physical examination and laboratory data are unremarkable. Colonoscopy revealed a large polypoid mass with short, thick stalk in the proximal transverse colon, approximately 70–75 cm from anal verge (). The polypoid mass appeared smooth, with a shiny pink mucosa; the mucosa overlying the mass lesion and stalk was similar to t... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121389 Mon, 23 Nov 2009 00:00:00 +0100 3121389 What's Causing This Woman's Chest Pain? http://www.medworm.com/index.php?rid=3121388&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509007410%2Fabstract%3Frss%3Dyes Question: A 64-year-old woman was initially diagnosed with a potentially resectable pancreatic adenocarcinoma after workup for deep venous thrombosis and pulmonary emboli in November 2005. A Whipple procedure was performed and pathologic staging was T1N1 with 15/27 regional nodes involved (stage IIB). Adjuvant chemotherapy was administered using erlotinib and gemcitabine for 6 months ending in April 2006. Her first recurrence occurred in May 2006 in a retrocrural node. The patient underwent radiation therapy with concurrent capecitabine. The patient had a good radiologic response to therapy, and remained free of progression or recurrence until June 2007, when she presented with an enlarged node in the left supraclavicular area. A biopsy of the node confirmed metastatic adenocarcinoma; the ... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121388 Mon, 23 Nov 2009 00:00:00 +0100 3121388 The Stomach That “Cracked” Under Pressure http://www.medworm.com/index.php?rid=3121386&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509018794%2Fabstract%3Frss%3Dyes Question: A 17-year-old girl presented to her general practitioner with an unrelated problem, and was noticed to look pale. She experienced mild fatigue, but was otherwise asymptomatic. Her menses were normal and there was no overt bleeding. Her body mass index was 23.5 kg/m2, and she had adequate dietary intake of iron. There was no salicylate, non-steroidal anti-inflammatory, or alternative/herbal medication use. Her only medical history was eczema for which she used mometasone ointment topically. A third cousin had celiac disease, but family medical history was otherwise unremarkable. Physical examination revealed pallor only. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121386 Mon, 23 Nov 2009 00:00:00 +0100 3121386 The Ying and Yang of Bacterial Signaling in Necrotizing Enterocolitis http://www.medworm.com/index.php?rid=3121385&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509020484%2Fabstract%3Frss%3Dyes See “Toll-like receptor-4 inhibits enterocyte proliferation via impaired β-catenin signaling in necrotizing enterocolitis,” by Sodhi CP, Shi X–H, Richardson WM, et al, on page 185. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121385 Mon, 23 Nov 2009 00:00:00 +0100 3121385 A Unique Subset of Peyer's Patches Express Lysozyme http://www.medworm.com/index.php?rid=3121384&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509020502%2Fabstract%3Frss%3Dyes See “Pathogenic bacteria and dead cells are internalized by a unique subset of Peyer's patch dendritic cells that express lysozyme,” by Lelouard H, Henri S, De Bovis B, et al, on page 173. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121384 Mon, 23 Nov 2009 00:00:00 +0100 3121384 Do Differences in Pegylation of Interferon Alfa Matter? http://www.medworm.com/index.php?rid=3121383&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509020514%2Fabstract%3Frss%3Dyes See “Randomized study of peginterferon-α2a plus ribavirin vs peginterferon-α2b plus ribavirin in chronic hepatitis C,” by Rumi MG, Aghemo A, Prati GM, et al, on page 108; and “Peginterferon alpha-2a plus ribavirin is more effective than peginterferon alpha-2b plus ribavirin for treating chronic hepatitis C virus infection,” by Ascione A, De Luca M, Tartaglione MT, et al, on page 116. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121383 Mon, 23 Nov 2009 00:00:00 +0100 3121383 Reducing the Gastrointestinal Risks of Low-Dose Aspirin http://www.medworm.com/index.php?rid=3121382&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508509020496%2Fabstract%3Frss%3Dyes See “Famotidine is inferior to pantoprazole in preventing recurrence of aspirin-related peptic ulcers or erosions,” by Ng F–H, Wong S–Y, Lam K–F, et al, on page 82. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3121382 Mon, 23 Nov 2009 00:00:00 +0100 3121382