MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Gastroenterology' source. Wed, 08 Feb 2012 16:28:16 +0100 http://www.medworm.com/index.php?rid=5629724&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511017252%2Fabstract%3Frss%3Dyes Copyright Assignment. In consideration of the American Gastroenterological Association (AGA) Institute (the “AGA Institute”) taking action to review and credit the below-identified submission (the “Manuscript”), and for other valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned authors and/or creators (the “Authors”), jointly and severally, hereby transfer, convey, and assign to the AGA Institute, free and clear of any liens, licenses or encumbrances, the entire right, title, and interest in and to the Manuscript throughout the world, including without limitation in and to any and all copyrights for the Manuscript (including but not limited to rights to copy, publish, excerpt, collect royalties and make derivative works) in print,... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629724 Thu, 26 Jan 2012 21:26:23 +0100 5629724 http://www.medworm.com/index.php?rid=5629723&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511017240%2Fabstract%3Frss%3Dyes Gastroenterology is the premiere journal in the field of gastrointestinal disease and is led by an internationally renowned board of editors. As the official journal of the AGA Institute, Gastroenterology delivers up-to-date and authoritative coverage of both basic and clinical gastroenterology and hepatology. Regular features include research and perspectives by leading authorities, reports on the latest technologies for diagnosing and treating digestive diseases, images illustrating important clinical findings, reviews of scholarly media, medical news, meeting summaries, video abstracts, and monthly podcasts. Gastroenterology also bridges the gap between basic and clinical science by publishing comprehensive reviews on important topics such as pancreatitis and liver disease (Source: Gast... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629723 Thu, 26 Jan 2012 21:26:23 +0100 5629723 http://www.medworm.com/index.php?rid=5629722&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511017239%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629722 Thu, 26 Jan 2012 21:26:23 +0100 5629722 http://www.medworm.com/index.php?rid=5629721&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511017227%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629721 Thu, 26 Jan 2012 21:26:23 +0100 5629721 http://www.medworm.com/index.php?rid=5629664&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511017203%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629664 Thu, 26 Jan 2012 21:26:21 +0100 5629664 http://www.medworm.com/index.php?rid=5629714&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508512000091%2Fabstract%3Frss%3Dyes Polyak SJ, Morishima C, Scott JD, et al. A summary of the 18th international symposium on hepatitis C virus and related viruses. Gastroenterology 2012;142:e1–e5. In the above article, Pablo Gastaminza, PhD, Departamento de Biología Celular y Molecular, Centro Nacional de Biotecnología-CSIC, Madrid, Spain, should be listed as the 4th author in the article's byline. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629714 Mon, 09 Jan 2012 05:00:00 +0100 5629714 http://www.medworm.com/index.php?rid=5629680&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511002952%2Fabstract%3Frss%3Dyes Question: A 45-year-old woman with a history of a gastric ulcer 10 years ago presented to the outpatient department with vague upper abdominal discomfort for 5 years. She had no history of abdominal surgery. She denied having poor appetite and weight loss. Physical examination showed a moderately nourished lady, not anemic in appearance; a firm, large, nontender mass was distinguished in the left upper abdominal quadrant. All blood tests were normal, including tumors markers (carcinoembryonic antigen, alfa-fetoprotein, carbohydrate antigen 19-9, and carbohydrate antigen 125). Chest x-ray showed normal heart size with clear lung fields. The abdominal ultrasonography revealed a 10-cm hypoechoic heterogeneous mass at the left upper abdomen, which was located lateral to the left kidney and nex... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629680 Mon, 26 Dec 2011 05:00:00 +0100 5629680 http://www.medworm.com/index.php?rid=5629670&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511017008%2Fabstract%3Frss%3Dyes See “Estimates of early death, acute liver failure, and long-term mortality among live liver donors,” by Muzaale AD, Dagher NN, Montgomery RA, et al, on page 273. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629670 Mon, 26 Dec 2011 05:00:00 +0100 5629670 http://www.medworm.com/index.php?rid=5629684&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511010328%2Fabstract%3Frss%3Dyes Question: A 60-year-old Caucasian woman presented with melena of 3 days' duration. It was the second episode of gastrointestinal (GI) bleeding. Fourteen days ago, colonoscopy done in another hospital revealed diverticulosis and 3 small polypoid lesions in the cecum without signs of acute bleeding. Biopsies of the lesions have been taken. Gastroscopy was normal. At admission to our hospital, the patient was hemodynamically stable. Laboratory findings showed hemoglobin level of 80 g/L (normal limits, 121–154 g/L) and thrombocytes of 34 g/L (normal limits, 140–380 g/L). (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629684 Fri, 23 Dec 2011 05:00:00 +0100 5629684 http://www.medworm.com/index.php?rid=5629681&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511002964%2Fabstract%3Frss%3Dyes Question: A 63-year-old man presented with acute onset of slurred of speech that resolved within a few hours. He was recently diagnosed with cirrhosis secondary to hepatitis C and alcohol. He had lost 10 kg over the past year. He appeared thin and frail and was afebrile with normal vitals. Jaundice, hepatosplenomegaly, and ascites were not present. The abdomen was nondistended and nontender. His cardiac examination was normal, and he had no lymphadenopathy. Neurologic examination was normal with no asterixis. His laboratory tests showed: hemoglobin, 10 g/dL (normal, 14–18 g/dL); platelet count, 82 (normal, 140–440 K/UL); International Normalized Ratio, 1.2 (normal, 2–3); creatinine, 1 mg/dL (normal, 0.7–1.3 mg/dL); alkaline phosphatase, 127 IU/L (normal, 25–100 U/L); alanine amin... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629681 Fri, 23 Dec 2011 05:00:00 +0100 5629681 http://www.medworm.com/index.php?rid=5629679&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511003519%2Fabstract%3Frss%3Dyes Question: An 85-year-old woman was referred to our institution with a palpable mass in the upper abdomen. Her past medical history was unremarkable except for arterial hypertension and coronary artery disease. Lately, she had experienced frequent episodes of drenching sweats. On physical examination, a large mass was palpated in the upper abdomen. Computed tomography showed a large, heterogenous liver tumor of the left lobe measuring 17 cm in diameter (). The liver showed no signs of cirrhosis and no other lesions or pathologic findings were observed in the abdomen or the thorax. Before undergoing surgery the patient had to be treated in the intensive care unit for hypoglycemic shock (lowest blood glucose level, 32 mg/dL). Laparotomy showed an extensive, lobulated liver tumor of the left l... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629679 Fri, 23 Dec 2011 05:00:00 +0100 5629679 http://www.medworm.com/index.php?rid=5526021&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015940%2Fabstract%3Frss%3Dyes Copyright Assignment. In consideration of the American Gastroenterological Association (AGA) Institute (the “AGA Institute”) taking action to review and credit the below-identified submission (the “Manuscript”), and for other valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned authors and/or creators (the “Authors”), jointly and severally, hereby transfer, convey, and assign to the AGA Institute, free and clear of any liens, licenses or encumbrances, the entire right, title, and interest in and to the Manuscript throughout the world, including without limitation in and to any and all copyrights for the Manuscript (including but not limited to rights to copy, publish, excerpt, collect royalties and make derivative works) in print,... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5526021 Thu, 22 Dec 2011 09:32:01 +0100 5526021 http://www.medworm.com/index.php?rid=5526020&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015939%2Fabstract%3Frss%3Dyes Gastroenterology publishes clinical and basic studies of all aspects of the digestive system, including the liver and pancreas, as well as nutrition. The types of articles Gastroenterology publishes include original papers, review articles, and special category manuscripts. Manuscripts must be prepared in accordance with the “Uniform Requirements for Manuscripts Submitted to Biomedical Journals” developed by the International Committee of Medical Journal Editors (http://www.icmje.org). Gastroenterology is a member of the Committee on Publication Ethics (COPE) (http://www.publicationethics.org.uk). (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5526020 Thu, 22 Dec 2011 09:32:01 +0100 5526020 http://www.medworm.com/index.php?rid=5526019&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015927%2Fabstract%3Frss%3Dyes Gastroenterology is the premiere journal in the field of gastrointestinal disease and is led by an internationally renowned board of editors. As the official journal of the AGA Institute, Gastroenterology delivers up-to-date and authoritative coverage of both basic and clinical gastroenterology and hepatology. Regular features include research and perspectives by leading authorities, reports on the latest technologies for diagnosing and treating digestive diseases, images illustrating important clinical findings, reviews of scholarly media, medical news, meeting summaries, video abstracts, and monthly podcasts. Gastroenterology also bridges the gap between basic and clinical science by publishing comprehensive reviews on important topics such as pancreatitis and liver disease. (Source: Gas... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5526019 Thu, 22 Dec 2011 09:32:01 +0100 5526019 http://www.medworm.com/index.php?rid=5526018&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015915%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5526018 Thu, 22 Dec 2011 09:32:01 +0100 5526018 http://www.medworm.com/index.php?rid=5526017&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015903%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5526017 Thu, 22 Dec 2011 09:32:01 +0100 5526017 http://www.medworm.com/index.php?rid=5525967&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015484%2Fabstract%3Frss%3Dyes Nearly 800 researchers from around the world attended the 18th International Symposium on Hepatitis C Virus and Related Viruses in Seattle, Washington, from September 8 to 12, 2011. The following report summarizes key aspects of the 96 oral presentations and 420 posters presented at the meeting. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5525967 Thu, 22 Dec 2011 09:31:59 +0100 5525967 http://www.medworm.com/index.php?rid=5525965&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015885%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5525965 Thu, 22 Dec 2011 09:31:59 +0100 5525965 http://www.medworm.com/index.php?rid=5629713&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511017136%2Fabstract%3Frss%3Dyes This is another issue of the successful “Curbside Consultation” textbook series published by SLACK Incorporated. This new addition to the series focuses on the area of gastrointestinal cancers and is a timely release considering the growing complexities and nuances related to the management of colorectal cancer, esophageal adenocarcinoma, pancreatic cancer, and hepatocellular cancer. Colorectal cancer is the third leading cause of cancer and second leading cause of cancer-related death, causing an estimated 50,000 deaths in 2011. Esophageal adenocarcinoma is 1 of the few cancers with a rising incidence and has a poor 5-year survival rate. Pancreatic cancer continues to carry a dismal prognosis and has become increasingly publicized by the media as more celebrities such as Patrick Swayz... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629713 Thu, 22 Dec 2011 05:00:00 +0100 5629713 http://www.medworm.com/index.php?rid=5629711&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511017112%2Fabstract%3Frss%3Dyes The field of hepatology has grown exponentially over the past 40 years both in the clinical and research arenas. This has accompanied the world-wide recognition of the burden of chronic liver disease including alcoholic liver disease, hepatitis B, hepatitis C, nonalcoholic liver disease, and end-stage liver disease and hepatocellular cancer. Major advances in our understanding of these diseases along with major therapeutic advances including treatments for viral hepatitis; autoimmune, cholestatic, and metabolic liver diseases; alcoholic hepatitis; end-stage liver disease; and the ultimate therapy for end-stage liver disease, liver transplantation, have allowed hepatologists to improve the lives of those with chronic liver disease while extending survival and in many instances, curing our p... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629711 Thu, 22 Dec 2011 05:00:00 +0100 5629711 http://www.medworm.com/index.php?rid=5629685&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511010341%2Fabstract%3Frss%3Dyes Question: A 63-year-old man with a long-standing medical history of anemia presented to the gastroenterology outpatient clinic with diffuse abdominal pain, progressive dragging sensation in the left upper quadrant, and marked dizziness. Other prominent clinical symptoms included a weight loss of 15 lbs over 2 months, anorexia, and intermittent constipation. Clinical examination revealed tenderness in the left upper quadrant and massive splenomegaly. On further palpation, the spleen extended to the umbilicus, and had a smooth surface and a very firm consistency. The patient was hemodynamically stable with an arterial blood pressure of 111/56 mmHg and a heart rate of 90 beats/min. A complete blood cell count showed anemia (hemoglobin, 5.7 g/dL) and a normal platelet count. No abnormalities w... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629685 Thu, 22 Dec 2011 05:00:00 +0100 5629685 http://www.medworm.com/index.php?rid=5629683&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS001650851101033X%2Fabstract%3Frss%3Dyes Question: A 37-year-old Caucasian woman sought medical attention for intermittent dysphagia for both liquids and solids, loss of appetite, and a 5-kg weight loss in the past 3 months. She denied other symptoms such as fever, productive cough, or diarrhea. The patient history was significant for HIV-1; infection was diagnosed 15 years previously. She was noncompliant with medical follow-up or antiretroviral therapy for the last 5 years. On physical examination, the patient was visibly malnourished, with a body mass index of 15 kg/m2. Chest and heart examination were unremarkable. Abdominal examination revealed a diffusely tender abdomen without hepatosplenomegaly. There were no palpable lymph nodes. Laboratory assessment revealed a normocytic normochromic anemia of 11.6 g/dL, low platelet c... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629683 Thu, 22 Dec 2011 05:00:00 +0100 5629683 http://www.medworm.com/index.php?rid=5629682&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511010316%2Fabstract%3Frss%3Dyes Question: A previously healthy 64-year-old man presented to the emergency department with a 4-day duration of progressive and diffuse abdominal pain. The pain, seemingly unrelated to meals or postural change, began with intermittent cramps and progressed to a steady, constant ache. Physical examination revealed marked lower quadrant tenderness, diffuse peritoneal sign, and reduced bowel sounds. Deep tenderness at McBurney's point was not obvious. Laboratory investigation disclosed leukocytosis with a left shift, and the remaining tests were unremarkable. Contrast-enhanced computed tomography (CT) was performed (). (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629682 Thu, 22 Dec 2011 05:00:00 +0100 5629682 http://www.medworm.com/index.php?rid=5629678&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511002940%2Fabstract%3Frss%3Dyes Question: A 53-year-old African American woman was diagnosed with κ-light chain multiple myeloma in 2005. She underwent chemotherapy previously, and stem cell transplantation 4 months before the current hospitalization. She presented with acute upper gastrointestinal (GI) bleeding in the form of hematemesis. The patient underwent emergent esophagogastroduodenoscopy. There was no evidence of active bleeding. A multilobulated, submucosal mass, about 4 × 4 cm, with an overlying ulceration measuring about 10 mm was seen, occupying the proximal corpus along the greater curvature (). The ulcer had a nonbleeding visible vessel in its base (); this vessel was successfully ablated with bipolar cautery. Repeat GI endoscopy was performed 4 days later, which revealed the gastric mass, without eviden... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629678 Thu, 22 Dec 2011 05:00:00 +0100 5629678 http://www.medworm.com/index.php?rid=5629677&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511002903%2Fabstract%3Frss%3Dyes Question: A 33-year-old man with history of right inguinal hernia presented with progressive abdominal pain for 1 week. On examination he had a soft right inguinal mass with diffuse peritonitis, and laboratory tests revealed an elevated white cell count (13 × 109/L). Abdominal computed tomography demonstrated a pathognomonic whirling fatty mass in the omentum (, black arrow) with diffuse abdominal/pelvic fatty infiltration (, arrowhead) extending into right inguinal canal next to the hernia (, white arrow). (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629677 Thu, 22 Dec 2011 05:00:00 +0100 5629677 http://www.medworm.com/index.php?rid=5629676&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511003532%2Fabstract%3Frss%3Dyes Question: A 35-year-old man presented to our gastrointestinal clinic with a 4-week history of sudden onset emesis and upper abdominal pain in the right epigastrium. Alarming symptoms, such as dysphagia, weight loss, vomiting, or gastrointestinal bleeding, were not reported. Physical examination revealed no abnormalities. Initial laboratory investigations showed elevation of alanine transaminase (54.6 U/L), alkaline phosphatase (147.6 U/L), and lactate dehydrogenase (353.4 U/L) levels. Upper gastrointestinal endoscopy revealed multiple nodular polypoid dark lesions of the esophagus (), the gastric antrum and corpus (), and the bulbus duodeni. The lesions measured 3–20 mm in diameter, were vulnerable, and were partly ulcerated. Multiple biopsy specimens of the esophagus () and gastric corp... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629676 Thu, 22 Dec 2011 05:00:00 +0100 5629676 http://www.medworm.com/index.php?rid=5629675&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511002915%2Fabstract%3Frss%3Dyes Question: A 79-year-old man presented with a 1-year history of intermittent colicky abdominal pain, without rectal blood loss or fever. On physical examination, the abdomen was not distended, there were normal bowel sounds and no rebound tenderness or peritoneal guarding. The laboratory results were all normal. Colonoscopy revealed mild diverticulosis of the sigmoid colon. Additionally, we observed a thin, stalk-like lesion, the distal end of which seemed to be trapped in a peristaltic wave, resulting in considerable strain to the tissue, not unlike a stretched snare (). At that moment, the patient experienced abdominal pain. After the peristaltic wave had passed, the colicky pain resolved, and the entire lesion became visible (): Arising from a wide pseudo-pedicle, a 10-cm-long stalk with... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629675 Thu, 22 Dec 2011 05:00:00 +0100 5629675 http://www.medworm.com/index.php?rid=5629720&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511017197%2Fabstract%3Frss%3Dyes We thank Colecchia et al for their comments in connection with our study, in which we demonstrated that common blood work and imaging variables can be utilized for estimating the likelihood of the presence of varices in children and thereby help determine which children should undergo esophagogastroduodenoscopy (EGD). There is a notable lack of pediatric data regarding the diagnosis and management of esophageal varices. It is therefore not surprising that we have previously shown a significant variation in practice amongst pediatric hepatologists, many of whom perform screening endoscopies in selected children at risk of varices. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629720 Wed, 21 Dec 2011 05:00:00 +0100 5629720 http://www.medworm.com/index.php?rid=5629717&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS001650851101715X%2Fabstract%3Frss%3Dyes In the September 2011 issue of Gastroenterology, Tuo et al demonstrated that the well-known rarity of duodenal ulcer in premenopausal women was associated with decreased duodenal bicarbonate secretion (DBS), that serum levels of estradiol changed in parallel with basal and acid-stimulated DBS during the menstrual cycle, and that estrogen receptors were detected in human duodenal cells. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629717 Wed, 21 Dec 2011 05:00:00 +0100 5629717 http://www.medworm.com/index.php?rid=5629716&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511017173%2Fabstract%3Frss%3Dyes We thank Drs Das and Rajalingham for their interests and thoughtful comments on our article, and also would like to answer their questions and concerns on our paper. Peptic ulcers, especially duodenal ulcers, are common alimentary diseases with high prevalence. Although it has been clinically observed for many years that duodenal ulcer occurs more often in men than in women, the reason for these gender differences is not clear. Our present study demonstrates for the first time that estrogen regulates human duodenal bicarbonate secretion (DBS), which could reduce the risk for duodenal ulcer in women and contribute to gender differences in the prevalence of duodenal ulcer. We would like to stress here that the present experimental results obtained from the humans are consistent with the find... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629716 Wed, 21 Dec 2011 05:00:00 +0100 5629716 http://www.medworm.com/index.php?rid=5629715&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511017148%2Fabstract%3Frss%3Dyes We enjoyed reading the recently published article “Estrogen Regulation of Duodenal Bicarbonate Secretion and Sex-Specific Protection of Human Duodenum” by Tuo et al. We congratulate the investigators for carrying out the first ever human study on the effects of estrogen on human duodenal bicarbonate secretion (DBS). The previous studies were all murine based. Perhaps the only disadvantage is that the present results cannot be compared with the findings of earlier studies. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629715 Wed, 21 Dec 2011 05:00:00 +0100 5629715 http://www.medworm.com/index.php?rid=5629710&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511017100%2Fabstract%3Frss%3Dyes Park JM, Choi MG, Cho YK. Cannabinoid receptor 1 gene polymorphism and irritable bowel syndrome in the Korean population: a hypothesis-generating study. J Clin Gastroenterol 2011;45:45–49. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629710 Wed, 21 Dec 2011 05:00:00 +0100 5629710 http://www.medworm.com/index.php?rid=5629709&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511017082%2Fabstract%3Frss%3Dyes Kappelman MD, Horvath-Puho E, Sandler RS, et al. Thromboembolic risk among Danish children and adults with inflammatory bowel diseases: a population-based nationwide study. Gut 2011;60:937–943. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629709 Wed, 21 Dec 2011 05:00:00 +0100 5629709 http://www.medworm.com/index.php?rid=5629708&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511017070%2Fabstract%3Frss%3Dyes Kamm MA, Mueller-Lissner S, Wald A, et al. Oral bisacodyl is effective and well-tolerated in patients with chronic constipation. Clin Gastroenterol Hepatol 2011;9:577–583. Chronic constipation (CC) is a common gastrointestinal disorder with a varying prevalence depending on the definition used to establish the diagnosis. Overall, 12%–19% of Americans are affected (Am J Gastroenterol 2004;9:750–759), and CC is the second most common ambulatory diagnosis made by gastroenterologists. Its pathogenesis derives from a heterogeneous combination of secondary causes—age, medications, electrolyte imbalances, endocrinopathies, and musculoskeletal disorders—as well as primary causes including normal and slow transit constipation and evacuation disorders. Despite the variety of etiologies, r... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629708 Wed, 21 Dec 2011 05:00:00 +0100 5629708 http://www.medworm.com/index.php?rid=5629706&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511017094%2Fabstract%3Frss%3Dyes Li J, Ashrafian H, Bueter M, et al. Metabolic surgery profoundly influences gut microbial-host metabolic cross-talk. Gut 2011;60:1214–1223. Obesity, one of the great pandemics of our time, is a major threat to public health and a challenge to health care resources. This complex syndrome is influenced by host susceptibility and by environmental or lifestyle factors, such as diet and physical activity. Obesity is associated with a number of serious health consequences, including type 2 diabetes, cardiovascular disease, pulmonary hypertension, obstructive sleep apnea, gastroesophageal reflux disease, musculoskeletal disorders, and a variety of cancers (Mayo Clin Proc 2006;81[suppl]:S5–S10) and has been repeatedly shown to be associated with an increased risk of mortality (Gastroenterolog... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629706 Wed, 21 Dec 2011 05:00:00 +0100 5629706 http://www.medworm.com/index.php?rid=5629674&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511010353%2Fabstract%3Frss%3Dyes Question: A 59-year-old woman presented to the emergency department with nausea and epigastric pain for 2 days preceded by 2 weeks of anorexia. Several years ago, she was diagnosed as glucose intolerant, but did not receive regular follow-up. On examination, her temperature was 34.8°C and her blood pressure was 81/53 mm Hg. She had icteric sclera, palpated tenderness in the upper right quadrant of the abdomen, and hepatomegaly (liver span of 14 cm at the midclavicular line). Blood tests showed a leukocyte count of 5700/mm3, (55% neutrophils; 19% lymphocytes), a glucose level of 347 mg/100 mL, an aspartate aminotransferase of 10,920 U/L, an alanine aminotransferase level of 3651 U/L, a total bilirubin of 4.8 mg/dL, and a creatinine level of 3.4 mg/100 mL. Plain film of the chest was normal... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629674 Wed, 21 Dec 2011 05:00:00 +0100 5629674 http://www.medworm.com/index.php?rid=5629673&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511002861%2Fabstract%3Frss%3Dyes Question: A 74-year-old man underwent gastroscopy owing to severe nausea, vomitus, and fluctuating mild epigastric discomfort of 2 months' duration. He had known chronic renal failure with a creatinine clearance of 32 mL/min (Modification of Diet in Renal Disease formula), diabetes mellitus, and coronary heart disease with a history of myocardial infarction. The patient reported initiation of his current gastrointestinal (GI) symptoms within several hours after a coronary angiography with stent implantation in the right coronary artery owing to worsening chest pain. He attributed his new symptoms to the actual change of his cardiac medication after percutaneous coronary angiography. A marked deterioration in the patient's current renal function (glomerular filtration rate, 14 mL/min) was n... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629673 Wed, 21 Dec 2011 05:00:00 +0100 5629673 http://www.medworm.com/index.php?rid=5629672&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511004379%2Fabstract%3Frss%3Dyes Question: A 45-year-old man presented to the hospital with coffee ground emesis, melena, and syncope. Initial evaluation revealed signs of hemodynamic instability with a heart rate of 120 beats/min and a blood pressure of 88/62 mmHg. Initial laboratory investigations were normal except for a decreased hemoglobin level of 7.8 g/dL (normal, 13.0–17.0). After resuscitation, an evaluation for suspected upper gastrointestinal bleeding using an esophagogastroduodenoscope was performed; a focal area of mucosal erythema was noticed in the fundus with enlarged mucosal folds, no blood or active bleeding was seen. Endoscopic ultrasonography (EUS) was performed and revealed multiple, well-circumscribed, anechoic, tubular structures, that demonstrated vascular flow on color Doppler (), the appearance... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629672 Wed, 21 Dec 2011 05:00:00 +0100 5629672 http://www.medworm.com/index.php?rid=5629671&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511003556%2Fabstract%3Frss%3Dyes Question: A 73-year-old man without medical history was admitted to the Intensive Care Unit (ICU) for shock. The day before ICU admission, he suddenly experienced nausea and abdominal pain, and vomited twice. On admission, core temperature was 37.9°C, heart rate was 86 beats/min, and blood pressure was 70/36 mmHg. Painful abdominal distension without occlusion was noticed. Arterial blood gases on room air showed: pH, 7.19; HCO3−, 9 mmol/L; PaCO2, 24 mmHg; PaO2, 105 mmHg; lactate, 9.3 mmol/L. Blood work showed: glycemia, 21.4 mmol/L; creatininemia, 306 μmol/L; hemoglobin, 16 g/dL; leukocytes, 9.4 g/L; platelets, 153 g/L; alanine aminotransferase, 412 IU/L; aspartate aminotransferase, 204 IU/L; lactate dehydrogenase, 1586 IU/L; alkaline phosphatase, 111 IU/L; total bilirubin, 42 μmol/L,... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629671 Wed, 21 Dec 2011 05:00:00 +0100 5629671 http://www.medworm.com/index.php?rid=5629719&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511017161%2Fabstract%3Frss%3Dyes We read with great interest the paper by Gana et al regarding the prognostic value of the clinical predictive rule (CPR) in children at risk of esophagogastric varices (EGV). The authors studied 108 children with chronic liver disease or portal vein obstruction who underwent esophagogastroduodenoscopy (EGD) to assess the presence of esophageal or gastric varices. The aim of the study was to evaluate the predictive value of the noninvasive clinical prediction rule and other noninvasive parameters, such as splenomegaly on physical examination, spleen length z score measured by ultrasound, platelet count, and platelet:spleen size z-score ratio (P/SSAZ). The authors observed that, in their population (in which there was a prevalence of EGV of 69%), 87% of the children with a positive CPR had v... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629719 Mon, 19 Dec 2011 05:00:00 +0100 5629719 http://www.medworm.com/index.php?rid=5629718&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511017185%2Fabstract%3Frss%3Dyes We thank Dr Baron for his interest in our article “Estrogen Regulation of Duodenal Bicarbonate Secretion and Sex-Specific Protection of Human Duodenum” published recently in Gastroenterology. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629718 Mon, 19 Dec 2011 05:00:00 +0100 5629718 http://www.medworm.com/index.php?rid=5629712&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511017124%2Fabstract%3Frss%3Dyes Endoscopic ultrasound (EUS) has emerged as a valuable diagnostic imaging modality since its introduction >30 years ago. There remains a need for enhanced EUS training that is not fully met by dedicated EUS training programs. Although technical skills are most readily acquired within a formal EUS fellowship, the education is facilitated by having a thorough knowledge of normal and abnormal EUS anatomy and a clear understanding of the concepts that apply to therapeutic EUS. Such educational material also benefits persons completing training to allow skill maintenance and continued intellectual and procedural growth. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629712 Mon, 19 Dec 2011 05:00:00 +0100 5629712 http://www.medworm.com/index.php?rid=5629707&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511017069%2Fabstract%3Frss%3Dyes We welcome the authors' comments in relation to our article published in Gut (2011;60:1214–1223) and wish to reiterate the point that referring to the role of gut microbiota as potentially being “mere epiphenomenon” needs to be strongly reconsidered. The whole field has moved beyond this notion and we should be thinking of where on the continuum of microbiome–host interactions this change in the composition falls. In the last 10 years, we have slowly begun to reintegrate the functions in the gut microbiome into host biology and there are many notable examples where they influence host; for example, bacterial glucuronidases impact chemotherapeutic treatments for colorectal cancer (Science 2010;330:831–835). In RYGB, there is a profound impact on the composition of the gut microbio... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629707 Mon, 19 Dec 2011 05:00:00 +0100 5629707 http://www.medworm.com/index.php?rid=5629686&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511017057%2Fabstract%3Frss%3Dyes Primary liver cancer is a disease arising from malignant transformation of hepatocytes, which account for up to 80% of the liver tissue. In infants, the most common form of liver tumor is hepatoblastoma (HB), a rare childhood tumor that mostly affects kids (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629686 Mon, 19 Dec 2011 05:00:00 +0100 5629686 http://www.medworm.com/index.php?rid=5629669&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS001650851101701X%2Fabstract%3Frss%3Dyes See “A high-fiber diet does not protect against asymptomatic diverticulosis,” by Peery AF, Barrett PR, Park D, et al, on page 266. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629669 Mon, 19 Dec 2011 05:00:00 +0100 5629669 http://www.medworm.com/index.php?rid=5629668&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511017045%2Fabstract%3Frss%3Dyes Subspecialty fellowship program directors (PDs) are keenly interested in monitoring and enhancing their trainees' academic progress throughout their fellowship experience. In addition to assessing trainee clinical acumen and knowledge base, PDs are required to demonstrate growth in clinical performance to validate advancement to subsequent training years, for which training programs have been confronted with increasing requirements by the Accreditation Council for Graduate Medical Education (ACGME). The ACGME has established core competency domains under which trainee progress can be objectively evaluated (medical knowledge, patient care, practice-based learning and improvement, systems-based practice, interpersonal and communication skills, and professionalism). These assessments potentia... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629668 Mon, 19 Dec 2011 05:00:00 +0100 5629668 http://www.medworm.com/index.php?rid=5629667&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511017033%2Fabstract%3Frss%3Dyes Published scientific papers are essential to disseminate research findings, and publications are a measure of academic productivity assessed for promotion and grant application. However, these are not perhaps the most important benefits of writing. As M. J. Mahoney once commented, “I would urge you to write not because it is a good thing, not because it is nice to see your name in print, but rather because you will really get to know a field only if you contribute to it” (Mahoney MJ, Psychology of the Scientist 1979). For most people, writing is an acquired skill, and success requires a continuum of self-discipline, basic rules and habits, and continuing practice. In addition to good writing, publishing in a scientific journal requires good science and a strategic approach that starts ... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629667 Mon, 19 Dec 2011 05:00:00 +0100 5629667 http://www.medworm.com/index.php?rid=5629666&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511016982%2Fabstract%3Frss%3Dyes Recently, I polled my GI friends to determine how they selected their dentist, and whether their dentist practiced “high-quality” dentistry. Most had received recommendations from friends, and selected a dentist based on convenience of location. I asked if they were happy with their dentist, and if the dentist was “above average,” “average,” or “below average” in terms of dental skills and expertise. Every dentist who takes care of my friends and colleagues is “above average.” Apparently, dentistry is like Lake Wobegon, where “all of the children are above average.” Then, I asked, “How do you know if your dentist is above average?” Did the dentist use low-dose digital imaging to reduce radiation; monitor and report rates of infection; report the frequency of rep... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629666 Mon, 19 Dec 2011 05:00:00 +0100 5629666 http://www.medworm.com/index.php?rid=5629665&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511017021%2Fabstract%3Frss%3Dyes Tobacco remains the most preventable cause of death in the world. Evidence supporting a carcinogenic role for tobacco has now expanded to 18 cancers. In this issue of Gastroenterology, 2 studies provide evidence that tobacco use, mainly in the form of cigarette smoking, increases the risk of colorectal adenoma formation in patients with the Lynch syndrome, and the development of high-grade dysplasia and cancer among patients with Barrett's esophagus. The 2 studies indicate that lifestyle changes such as abstention from tobacco use can affect predisposed individuals. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629665 Mon, 19 Dec 2011 05:00:00 +0100 5629665 http://www.medworm.com/index.php?rid=5629705&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511016404%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629705 Wed, 14 Dec 2011 05:00:00 +0100 5629705 http://www.medworm.com/index.php?rid=5629687&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511016362%2Fabstract%3Frss%3Dyes Aberrant Wnt/β-catenin signaling is widely implicated in numerous malignancies, including cancers of the gastrointestinal tract. Dysregulation of signaling is traditionally attributed to mutations in Axin, adenomatous polyposis coli, and β-catenin that lead to constitutive hyperactivation of the pathway. However, Wnt/β-catenin signaling is also modulated through various other mechanisms in cancer, including cross talk with other altered signaling pathways. A more complex view of Wnt/β-catenin signaling and its role in gastrointestinal cancers is now emerging as divergent phenotypic outcomes are found to be dictated by temporospatial context and relative levels of pathway activation. This review summarizes the dysregulation of Wnt/β-catenin signaling in colorectal carcinoma, hepatocell... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629687 Fri, 09 Dec 2011 05:00:00 +0100 5629687 http://www.medworm.com/index.php?rid=5525966&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015794%2Fabstract%3Frss%3Dyes Dysphagia is a common sequelae of stroke that increases the risk of aspiration pneumonia, malnutrition, and dehydration. In this issue of Gastroenterology, Michou et al describe a therapy to increase neuronal plasticity that results in improved swallowing performance in patients with severe, chronic dysphasia from stroke. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5525966 Mon, 28 Nov 2011 05:00:00 +0100 5525966 http://www.medworm.com/index.php?rid=5441929&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511014727%2Fabstract%3Frss%3Dyes Copyright Assignment. In consideration of the American Gastroenterological Association (AGA) Institute (the “AGA Institute”) taking action to review and credit the below-identified submission (the “Manuscript”), and for other valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned authors and/or creators (the “Authors”), jointly and severally, hereby transfer, convey, and assign to the AGA Institute, free and clear of any liens, licenses or encumbrances, the entire right, title, and interest in and to the Manuscript throughout the world, including without limitation in and to any and all copyrights for the Manuscript (including but not limited to rights to copy, publish, excerpt, collect royalties and make derivative works) in print,... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5441929 Fri, 25 Nov 2011 09:24:00 +0100 5441929 http://www.medworm.com/index.php?rid=5441928&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511014715%2Fabstract%3Frss%3Dyes Gastroenterology is the premiere journal in the field of gastrointestinal disease and is led by an internationally renowned board of editors. As the official journal of the AGA Institute, Gastroenterology delivers up-to-date and authoritative coverage of both basic and clinical gastroenterology and hepatology. Regular features include research and perspectives by leading authorities, reports on the latest technologies for diagnosing and treating digestive diseases, images illustrating important clinical findings, reviews of scholarly media, medical news, meeting summaries, video abstracts, and monthly podcasts. Gastroenterology also bridges the gap between basic and clinical science by publishing comprehensive reviews on important topics such as pancreatitis and liver disease. (Source: Gas... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5441928 Fri, 25 Nov 2011 09:23:59 +0100 5441928 http://www.medworm.com/index.php?rid=5441927&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511014703%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5441927 Fri, 25 Nov 2011 09:23:59 +0100 5441927 http://www.medworm.com/index.php?rid=5441926&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511014697%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5441926 Fri, 25 Nov 2011 09:23:59 +0100 5441926 http://www.medworm.com/index.php?rid=5441925&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015113%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5441925 Fri, 25 Nov 2011 09:23:59 +0100 5441925 http://www.medworm.com/index.php?rid=5441917&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511013680%2Fabstract%3Frss%3Dyes Although multiple medical professional societies, governmental agencies, and third-party payers recommend colorectal cancer (CRC) screening for adults at average or increased risk for CRC, screening rates for these populations continue to lag behind those of other malignancies. There are multiple reasons why population-wide CRC screening compliance remains “low” (near 50%–55%), and chief among them is the inconvenient, invasive, and/or uncomfortable nature of commonly used screening tests such as fecal occult blood testing, flexible sigmoidoscopy, and colonoscopy. In response, CRC screening technologies are constantly being developed and evaluated. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5441917 Fri, 25 Nov 2011 09:23:55 +0100 5441917 http://www.medworm.com/index.php?rid=5441872&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511014673%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5441872 Fri, 25 Nov 2011 09:23:45 +0100 5441872 http://www.medworm.com/index.php?rid=5526011&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015745%2Fabstract%3Frss%3Dyes Scientific and technological advances in colorectal cancer (CRC) became energized in the 1970s and took off ever since. The field has been moving so fast that one needs to reevaluate where we are periodically. So it is for a key aspect of CRC that has the potential to save lives—screening. The book edited by Drs Anderson and Kahi serves this purpose well. It is an excellent update, written by experienced and knowledgeable experts who have provided a comprehensive evidence based treatise of the field. Refreshingly, they do not stop there, but after analyzing the data, they give their personal opinions of where it's all at. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5526011 Thu, 24 Nov 2011 05:00:00 +0100 5526011 http://www.medworm.com/index.php?rid=5526016&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015782%2Fabstract%3Frss%3Dyes Thank you for your interest in our study, which demonstrated the effectiveness of entecavir monotherapy after liver transplantation for chronic hepatitis B (HBV)-related complications, with no graft loss attributed to hepatitis B recurrence. At the end of the follow-up period, 18 patients had hepatitis B surface antigen (HBsAg) positivity, with only 1 patient having detectable HBV DNA of very low levels. Furthermore, quantitative HBsAg levels performed at regular intervals for these 18 patients showed that the HBsAg levels remained at extremely low levels without evidence of rebound. We agree that HBsAg production is in part independent from HBV DNA production, as we have demonstrated the difference between quantitative HBsAg and HBV DNA levels over a 2-year period in patients treated with... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5526016 Wed, 23 Nov 2011 05:00:00 +0100 5526016 http://www.medworm.com/index.php?rid=5526015&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015125%2Fabstract%3Frss%3Dyes We read with interest the paper by Fung et al on the effect of entecavir (ETV) monoprophylaxis in 80 consecutive patients who received a liver transplant for hepatitis B-related disease. The authors claimed that ETV monoprophylaxis, without any Hepatitis B immune globulins (HBIG), was effective to prevent HBV reinfection. Indeed these results are much better than those reported with lamivudine monoprophylaxis, where the reinfection rate increased to more than 30%, with time post transplant, due to the emergence of an YMDD mutant. Since the first studies on the effect of HBIG monoprophylaxis on HBV recurrence, the definition of HBV infection after liver transplantation has been defined as the persistence or the reappearance of HBsAg in the serum. Using this criterion, the authors observed a... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5526015 Wed, 23 Nov 2011 05:00:00 +0100 5526015 http://www.medworm.com/index.php?rid=5526012&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015757%2Fabstract%3Frss%3Dyes The stated goal for books in this series is “to provide convenient, user-friendly handbooks for each organ system” to expedite frozen section diagnosis. This 96-page paperback book is divided into 8 chapters. The general discussion and assumptions regarding frozen section diagnosis stated in the prefaces and introductory chapters are insightful and on target. In particular, the focus on the surgeon's perspective in Chapter 2 is valuable (a surgeon, Mark Bloomston, is co-author for this chapter). Subsequent chapters focus on histopathologic diagnosis by frozen section with separate chapters that deal with the distinction between pancreatic ductal adenocarcinoma and chronic pancreatitis, variants of pancreatic adenocarcinoma, cystic lesions, other pancreatic neoplasms including neuroendo... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5526012 Wed, 23 Nov 2011 05:00:00 +0100 5526012 http://www.medworm.com/index.php?rid=5526009&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS001650851101571X%2Fabstract%3Frss%3Dyes Sugumar A, Levy MJ, Kamisawa T, et al. Endoscopic retrograde pancreatography criteria to diagnose autoimmune pancreatitis: an international multicentre study. Gut 2011;60:666–670. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5526009 Wed, 23 Nov 2011 05:00:00 +0100 5526009 http://www.medworm.com/index.php?rid=5526007&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015721%2Fabstract%3Frss%3Dyes Reinisch W, Sandborn WJ, Hommes DW, et al. Adalimumab for induction of clinical remission in moderately to severely active ulcerative colitis: results of a randomised controlled trial. Gut 2011;60:780–787. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5526007 Wed, 23 Nov 2011 05:00:00 +0100 5526007 http://www.medworm.com/index.php?rid=5526006&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015708%2Fabstract%3Frss%3Dyes Leiper K, Martin K, Ellis A, et al. Randomised placebo-controlled trial of rituximab (anti-CD20) in active ulcerative colitis. Gut 2011;60:1520–1526. B cells play a central role in the adaptive immune response against pathogens. A key role of B cells is to generate plasma cells and their precursor memory B cells, which are able to secrete antibodies in response to specific antigens. Increasing evidence has designated B cells as key players in the development and maintenance of many autoimmune diseases through the production of pathogenic antibodies. Thus, B-cell depletion strategies are expected to be a successful therapeutic option to treat autoimmune disease. The pathogenesis of ulcerative colitis (UC) is not well understood. However, the presence of antigoblet cell antibodies, perinu... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5526006 Wed, 23 Nov 2011 05:00:00 +0100 5526006 http://www.medworm.com/index.php?rid=5526005&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015678%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5526005 Wed, 23 Nov 2011 05:00:00 +0100 5526005 http://www.medworm.com/index.php?rid=5526004&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015770%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5526004 Wed, 23 Nov 2011 05:00:00 +0100 5526004 http://www.medworm.com/index.php?rid=5525981&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511003544%2Fabstract%3Frss%3Dyes Question: A 53-year-old man, a hepatitis B carrier, denied any systemic disease previously. He underwent routine abdominal ultrasonography screening in a local clinic and was referred to our hospital. He was diagnosed with multiple liver cystic lesions. There was no history of abdominal pain, body weight loss, or bowel habit change. Clinical examination was unrevealing with no evidence of hepatosplenomegaly or peripheral lymphadenopathy. Routine blood tests, including the liver function test, were completely normal. The abdominal ultrasound scan () showed multiple liver cystic lesions (arrows) and nodules with varying echogenicity (arrowheads). Abdominal computed tomography with contrast () showed multiple liver cystic lesions. Liver magnetic resonance imaging (MRI; ) was also arranged and... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5525981 Wed, 23 Nov 2011 05:00:00 +0100 5525981 http://www.medworm.com/index.php?rid=5525980&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511004422%2Fabstract%3Frss%3Dyes Question: A 66-year-old man was referred to our hospital because of progressive abdominal pain. He had experienced subumbilical dull pain accompanied by anorexia and dyspepsia for 2 days before he consulted the hospital. Change in bowel habits or weight loss was not noted. He had a history of benign prostate hyperplasia that was controlled by tamsulosin (α-blocker), left renal cell carcinoma (RCC; stage T2N0M0) treated with radical nephrectomy (6 years ago), and sarcomatoid carcinoma of the lung over the right lower zone (, arrow) that was managed by oral chemotherapy with uracil-tegafur in the oncology division for 3 years. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5525980 Wed, 23 Nov 2011 05:00:00 +0100 5525980 http://www.medworm.com/index.php?rid=5525979&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511002873%2Fabstract%3Frss%3Dyes Question: A 28-year-old man complained of 2 months of intermittent, dull, lower abdominal pain, abdominal fullness, and weight loss. He denied fever, diaphoresis, or constipation. On examination, he seemed to be uncomfortable, but his vital signs were normal. There were no oral ulcers lesions or lymphadenopathy. The abdomen was slightly distended with active bowel sounds in the lower quadrants. On palpation, there was lower abdominal tenderness without guarding or rebound. A tender mass was palpable in the right iliac fossa. Digital rectal examination yielded brown stool that tested negative for blood. The white blood cell count was 10,600/mm3 with 71% neutrophils. Results of a biochemistry panel and coagulation tests were within normal limits. Tests for Epstein-Barr virus and HIV were neg... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5525979 Wed, 23 Nov 2011 05:00:00 +0100 5525979 http://www.medworm.com/index.php?rid=5629693&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015769%2Fabstract%3Frss%3Dyes Conclusions: The risk of early death among live liver donors in the United States is 1.7 per 1000 donors. Mortality of live liver donors does not differ from that of healthy, matched individuals over a mean of 7.6 years. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629693 Mon, 21 Nov 2011 05:00:00 +0100 5629693 http://www.medworm.com/index.php?rid=5526008&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015691%2Fabstract%3Frss%3Dyes Schoggins JW, Wilson SJ, Panis M, et al. A diverse range of gene products are effectors of the type I interferon antiviral response. Nature 2011;472:481–485. Type I interferons (IFNs) are multifaceted cytokines with a central role in the host innate defense against viral infection. Upon viral infection, the host elicits a type I IFN response, mediated essentially by the expression of hundreds of IFN-stimulated genes (ISGs; Annu Rev Immunol 2005;23:307–336). Although it is assumed that these ISGs function together and are required for establishment of the antiviral state, few have been characterized regarding their antiviral potential, target specificity, and mechanisms of action. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5526008 Mon, 21 Nov 2011 05:00:00 +0100 5526008 http://www.medworm.com/index.php?rid=5525985&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511002927%2Fabstract%3Frss%3Dyes Question: A 47-year-old male smoker suffered from upper abdominal pain suddenly, and felt worse after meals. No diarrhea was noted. He went to the emergency department for help and his physical examination was normal except for epigastric tenderness. Biochemical tests showed elevated serum levels of amylase and lipase (amylase, 304 IU/L; lipase, 713 U/L), and bilirubin and blood sugar were within normal limit (total bilirubin, 0.56 mg/dL; postprandial glucose, 122 mg/dL). Abdominal magnetic resonance imaging for impression of acute pancreatitis displayed a dilated pancreatic duct and slight dilatation of the common bile duct. The hemograms and tumor markers including carcino-embryonic antigen, alpha-fetoprotein, and CA19-9 were within normal ranges. To exclude ampullary and/or periampullar... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5525985 Mon, 21 Nov 2011 05:00:00 +0100 5525985 http://www.medworm.com/index.php?rid=5525984&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511003520%2Fabstract%3Frss%3Dyes Question: A 65-year-old patient presented with a painful epigastric mass. It had been diagnosed as a hematoma after a blunt abdominal trauma 3 months prior. Since then, the mass remained and continued to cause the patient pain. Past medical history included chronic alcohol consumption and benign prostatic hyperplasia. Upon physical examination, he was determined to have a hard, irregular mass in the epigastric area associated with an ulcerated, 1.5 cm large nodule of the umbilicus (). Laboratory tests revealed a mild anemia (10 g/dL) with a low prothrombin time (63%) and a total bilirubinemia of 26 mg/L. His serum alpha-fetoprotein concentration was 16.8 ng/mL. Thoracoabdominopelvic computed tomographic (CT) was performed. It revealed a 12 × 7-cm solid mass in the epigastric region associ... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5525984 Mon, 21 Nov 2011 05:00:00 +0100 5525984 http://www.medworm.com/index.php?rid=5525983&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511004380%2Fabstract%3Frss%3Dyes Question: An 86-year-old woman was brought to the emergency department for right upper abdominal pain and fever for 3 days. Her medical history included hypertension and gastric cancer with Biliroth II gastrectomy and cholecystectomy 10 years previously. At admission, she was icteric, febrile, hypotensive (blood pressure, 64/44 mmHg), and tachycardic (pulse rate, 119 beats per minute). Laboratory examination revealed elevated white blood cell count of 10,800/mm3 with 57% of band form and total bilirubin of 2.03 mg/dL (normal, 0–1.2). Under the diagnosis of acute cholangitis, abdominal computed tomography (CT) was performed (, ). (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5525983 Mon, 21 Nov 2011 05:00:00 +0100 5525983 http://www.medworm.com/index.php?rid=5525982&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511002897%2Fabstract%3Frss%3Dyes Question: An 85-year old man presents with acute mental status changes and chronic watery diarrhea. His temperature was 98.9°F; pulse, 86; respiratory rate, 23; and blood pressure, 87/37 mmHg. His mucous membranes were dry, conjunctivae pale, and breath sounds clear bilaterally. A soft systolic ejection murmur was heard with an irregularly irregular heart beat. His abdomen and extremities were unremarkable. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5525982 Mon, 21 Nov 2011 05:00:00 +0100 5525982 http://www.medworm.com/index.php?rid=5525978&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511002848%2Fabstract%3Frss%3Dyes Question: A 69-year-old woman was admitted to our hospital complaining of worsening dysphagia for 1 month. She underwent mild dysphagia about 2 months ago. The patient occasionally sensed a feeling of foreign body in the throat for 6 months. She denied any dysphonia, regurgitation, retrosternal pain, or weight loss in the past 6 months. Physical examination revealed no obvious abnormality. The results of her hematologic and biochemical tests were normal, including erythrocyte sedimentation rate, C-reactive protein, and carcino-embryonic antigen. The patient had an uterine myometectomy 7 years ago. Chest computed tomography showed an occupying, multilobulated lesion in the proximal esophageal lumen. There was no lymphadenopathy in the mediastinum (). Upper gastrointestinal barium meal showe... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5525978 Mon, 21 Nov 2011 05:00:00 +0100 5525978 http://www.medworm.com/index.php?rid=5525977&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS001650851001886X%2Fabstract%3Frss%3Dyes Question: An 81-year-old man with a history of chronic kidney disease and a known history of diverticulosis was referred for capsule endoscopy for the workup of iron deficiency anemia. The capsule endoscopy study showed dark pigmentation in the stomach as well as the duodenum, which spared the papilla (). It also showed multiple arteriovenous malformations throughout the small bowel. A subsequent esophagogastroduodenoscopy (EGD) showed linear dark red/brown stripes in the antrum (). It also showed dark pigmentation of the duodenum similar to the capsule endoscopy (). Biopsies of the antrum and duodenum were obtained. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5525977 Mon, 21 Nov 2011 05:00:00 +0100 5525977 http://www.medworm.com/index.php?rid=5525976&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510018950%2Fabstract%3Frss%3Dyes Question: A 75-year-old Caucasian man sustained traumatic rib fractures with right-sided pneumothorax and right hip fracture after falling off a ladder. He underwent tube thoracostomy and repair of his hip fracture, and was doing relatively well until he suffered cardiopulmonary arrest 4 days later. He was successfully resuscitated after about 15 minutes and transferred to the intensive care unit. Mechanical ventilation and vasopressor support was required postresuscitation. Before cardiopulmonary arrest, there was no documented evidence of hypotension or tachycardia, and the triggering event was considered to be aspiration with attendant respiratory failure. It was discovered that the patient had a significant, 3-g decline in his hemoglobin over the preceding 24 hours, associated with som... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5525976 Mon, 21 Nov 2011 05:00:00 +0100 5525976 http://www.medworm.com/index.php?rid=5525975&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510018913%2Fabstract%3Frss%3Dyes Question: An 18-year-old woman presented to our emergency department with acute upper abdominal pain after the ingestion of food. Physical examination was normal except for a tender central epigastrium. She reported no regular medication and abstained from alcohol consumption and cigarette smoking. Laboratory findings included a C-reactive protein of 54 mg/L and a serum lipase of 10.041 U/L. Her serum electrolytes, liver enzymes, bilirubin, and blood count were within normal limits. Four weeks earlier, she had been admitted with a similar episode, which had resolved spontaneously and was diagnosed as acute pancreatitis without an obvious precipitating cause. Nine months earlier, a first episode of acute pancreatitis had occurred. Her past history was significant for elevated serum lipase a... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5525975 Mon, 21 Nov 2011 05:00:00 +0100 5525975 http://www.medworm.com/index.php?rid=5525974&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510018901%2Fabstract%3Frss%3Dyes Question: An 82-year-old man presented to the hospital with persistent nausea and indigestion, with a weight loss of 5 kg over the last 3 months. His vital signs were stable, and he showed no significant laboratory abnormalities except a decreased hemoglobin level of 9.6 g/dL (normal, 13.0–17.0). Esophagogastroduodenoscopy revealed a huge mass covered by abundant, whitish, mucinous materials resembling that of waterfalls falling down from the mass, with occasional glimpse of papillary structure in between the predominantly covered mucin (). Axial abdominal computed tomography revealed a large, tubular, multilobulated cystic dilatation that resembled a mass-like lesion involving almost the entire pancreas (, arrow). The upper portion of the mass directly extended to the gastric fundal are... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5525974 Mon, 21 Nov 2011 05:00:00 +0100 5525974 http://www.medworm.com/index.php?rid=5525973&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511002885%2Fabstract%3Frss%3Dyes Question: A 70-year-old Spanish woman with a history of rheumatoid arthritis has been treated for 1 year with adalimumab 40 mg subcutaneously every 2 weeks, prednisone 10 mg orally daily, and methotrexate 10 mg orally every week. She was admitted owing to abdominal pain and severe weight loss of 2-month duration. Physical examination was remarkable for a temperature of 37.2°C and distended abdomen with marked mesogastric tenderness to palpation. Laboratory tests showed mild anemia (11.4 g/dL) and elevated sedimentation rate (120 mm), in addition to an elevation of serum CA 125 (584.40 IU/mL; normal range, 0–35). Contrast-enhanced computed tomography showed smooth and uniform thickening of peritoneum (, arrowheads) and ascitic fluid in the pelvic recesses. Screening test results for tube... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5525973 Mon, 21 Nov 2011 05:00:00 +0100 5525973 http://www.medworm.com/index.php?rid=5525972&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS001650851100285X%2Fabstract%3Frss%3Dyes Question: In September 2009, a healthy, 28-year-old woman presented to the emergency department complaining of persistent, sharp, crampy abdominal pain, bilious vomiting, and lack of defecation for 3 days. She had come to the local emergency room several times with similar symptoms without any identified specific lesion. Her medical history was otherwise unremarkable. Physical examination revealed diffuse abdominal tenderness especially severe in the right lower quadrant. Her abdomen was soft, with noticeable extreme right lower abdominal rebound tenderness. An abdominal plain film showed local small intestinal dilatation. Significant laboratory data included mild leukocytosis (white blood cell count, 12,800/μL; normal range, 4000–10,000/μL) with a left shift. The abdominal pain progre... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5525972 Mon, 21 Nov 2011 05:00:00 +0100 5525972 http://www.medworm.com/index.php?rid=5525971&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510018949%2Fabstract%3Frss%3Dyes Question: A 73-year-old man with no previous medical history presented to our hospital with abdominal pain, distension, and a palpable abdominal mass. Abdominal ultrasonography revealed a well-circumscribed solid tumor containing cystic areas (). Computed tomography (CT) demonstrated a well-defined, solid tumor of 24.13 × 22.9 cm in diameter (). The patient underwent surgical treatment. At laparotomy, an elastic soft tumor was found originating from the mesentery and spreading to the pelvic space. The tumor had cystic areas and a vascular pedicle ranging from 5 to 6 cm in length (). There were no disseminated nodules and no liver metastasis. Complete operative resection of the neoplasm was performed and it was removed intact. His postoperative recovery was uneventful and he was discharged... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5525971 Mon, 21 Nov 2011 05:00:00 +0100 5525971 http://www.medworm.com/index.php?rid=5525970&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510018925%2Fabstract%3Frss%3Dyes Question: A 41-year-old man with long-standing luminal colonic and perianal Crohn's disease presented with persistent perianal symptoms, pain, indurated gluteus, and active drainage from an external fistula opening. He had been treated with azathioprine and infliximab for the past 5 months. Physical examination showed active draining of pus from fistulae openings in the gluteus and posterior perianal regions. A heterogeneous, protruding mass with ulcerative surface was also found in the perianal region (). Initial laboratory tests showed no significant changes. Patient underwent a colonoscopy, pelvic magnetic resonance imaging (MRI), and a biopsy of the suspicious mass at physical examination. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5525970 Mon, 21 Nov 2011 05:00:00 +0100 5525970 http://www.medworm.com/index.php?rid=5525969&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015654%2Fabstract%3Frss%3Dyes See “Alterations in lipid metabolism mediate inflammation, fibrosis, and proliferation in a mouse model of chronic cholestatic liver injury,” by Moustafa T, Fickert P, Magnes C, et al, on page 140; and “A high-cholesterol diet exacerbates liver fibrosis in mice via accumulation of free cholesterol in hepatic stellate cells,” by Teratani T, Tomita K, Suzuki T, et al, on page 152. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5525969 Mon, 21 Nov 2011 05:00:00 +0100 5525969 http://www.medworm.com/index.php?rid=5525986&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015642%2Fabstract%3Frss%3Dyes Eosinophilic esophagitis (EoE) is a relatively new disease with about a 10-fold increase in prevalence over the past 20 years. It has been found in approximately 6.5% of the population undergoing upper endoscopy. This disease has become one of the leading causes of dysphagia and food impaction in adults. For diagnosis, endoscopy is performed and multiple biopsies are collected at random throughout the length of the esophagus, including the proximal and distal regions. On histopathology, the primary feature of EoE is infiltration of eosinophils into the mucosa. These mediators of inflammation may contribute to the development of structural abnormalities of the esophagus, including edema, rings, furrows, and strictures. Clinical symptoms do not improve with high-dose proton pump inhibitor th... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5525986 Fri, 18 Nov 2011 05:00:00 +0100 5525986 http://www.medworm.com/index.php?rid=5525968&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015666%2Fabstract%3Frss%3Dyes Progress in the science and practice of medicine requires leveraging financial resources to pursue ideas, achieve new goals, and extend professional objectives. These resources are generally allocated through agencies that function through peer review. The need to convince a reviewing body, funding agency, or philanthropic foundation that these collective plans merit support is, therefore, a rate-limiting step. Herein I outline perspectives gained over years of writing and reviewing grants, and suggest themes to incorporate and traps to avoid in navigating this process. I focus the discussion on federal grant applications—specifically, independent investigator-initiated (R01) applications—commenting where relevant on mentored-type (K) award applications. The commonalities among these a... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5525968 Fri, 18 Nov 2011 05:00:00 +0100 5525968 http://www.medworm.com/index.php?rid=5629704&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015149%2Fabstract%3Frss%3Dyes Conclusions: Here we describe a novel mechanism for NFATc2-mediated gene regulation and identify a functional link among its repressor activity, the silencing of the suppressor pathway p15INK4b, and its pancreatic cancer growth regulatory functions. Thus, we provide evidence that inactivation of oncogenic NFATc2 might be an attractive strategy in treatment of pancreatic cancer. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629704 Fri, 11 Nov 2011 05:00:00 +0100 5629704 http://www.medworm.com/index.php?rid=5629702&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015162%2Fabstract%3Frss%3Dyes Conclusions: CCR9+ macrophages contribute to the induction of acute liver inflammation in mouse models of hepatitis. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629702 Fri, 11 Nov 2011 05:00:00 +0100 5629702 http://www.medworm.com/index.php?rid=5629700&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015137%2Fabstract%3Frss%3Dyes Conclusions: Basolateral ClC-2 channels are required for colonic electroneutral absorption of NaCl and KCl. The increase in the amiloride-sensitive short-circuit current in Clcn2−/− mice revealed a compensatory mechanism that is activated in the colons of mice that lack the ClC-2 channel. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629700 Fri, 11 Nov 2011 05:00:00 +0100 5629700 http://www.medworm.com/index.php?rid=5629697&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015150%2Fabstract%3Frss%3Dyes Conclusions: The copolymer P(HEMA-co-SS) reduced digestion of wheat gluten and barley hordein and attenuated the immune response to gluten in a food mixture in rodents. It might be developed to prevent or reduce gluten-induced disorders in humans. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629697 Fri, 11 Nov 2011 05:00:00 +0100 5629697 http://www.medworm.com/index.php?rid=5629695&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015174%2Fabstract%3Frss%3Dyes Conclusions: These findings provide evidence that claudin-18 normally forms a paracellular barrier against H+ in the stomach and that its deficiency causes paracellular H+ leak, a persistent up-regulation of proinflammatory cytokines, chronic recruitment of neutrophils, and the subsequent development of SPEM in atrophic gastritis. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629695 Fri, 11 Nov 2011 05:00:00 +0100 5629695 http://www.medworm.com/index.php?rid=5629694&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015101%2Fabstract%3Frss%3Dyes Conclusions: H pylori infection leads to development of chronic inflammation, hyperplasia, metaplasia, and dysplasia, as well as the recruitment and accumulation of BMDC in the gastric epithelial mucosa. Nearly 25% of dysplastic lesions include cells that originate from the BM. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629694 Mon, 07 Nov 2011 05:00:00 +0100 5629694 http://www.medworm.com/index.php?rid=5629692&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015095%2Fabstract%3Frss%3Dyes Conclusions: A high-fiber diet and increased frequency of bowel movements are associated with greater, rather than lower, prevalence of diverticulosis. Hypotheses regarding risk factors for asymptomatic diverticulosis should be reconsidered. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629692 Mon, 07 Nov 2011 05:00:00 +0100 5629692 http://www.medworm.com/index.php?rid=5629691&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS001650851101506X%2Fabstract%3Frss%3Dyes Conclusions: Adalimumab was safe and more effective than placebo in inducing and maintaining clinical remission in patients with moderate-to-severe ulcerative colitis who did not have an adequate response to conventional therapy with steroids or immunosuppressants. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629691 Mon, 07 Nov 2011 05:00:00 +0100 5629691 http://www.medworm.com/index.php?rid=5629690&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015058%2Fabstract%3Frss%3Dyes Conclusions: Early-stage CRC and large adenomas can be detected throughout the colorectum and with high levels of accuracy by the sDNA test. Neoplasm size, but not anatomical site, affected detection rates. Further studies are needed to validate the findings in a larger population and optimize the sDNA test. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629690 Mon, 07 Nov 2011 05:00:00 +0100 5629690 http://www.medworm.com/index.php?rid=5629689&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015071%2Fabstract%3Frss%3Dyes Conclusions: Among people with Lynch syndrome, current smokers have an increased risk of colorectal adenomas. Former smokers have a lower risk than current smokers, but greater risk than never smokers. Individuals with Lynch syndrome should be encouraged to avoid smoking. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629689 Mon, 07 Nov 2011 05:00:00 +0100 5629689 http://www.medworm.com/index.php?rid=5629688&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015083%2Fabstract%3Frss%3Dyes Conclusions: Smoking tobacco increases the risk of progression to cancer or high-grade dysplasia 2-fold among patients with BE, compared with patients with BE that have never smoked. Smoking cessation strategies should be considered for patients with BE. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629688 Mon, 07 Nov 2011 05:00:00 +0100 5629688 http://www.medworm.com/index.php?rid=5629701&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015022%2Fabstract%3Frss%3Dyes Conclusions: Activation of FXR transcription in the intestine protects the liver from cholestasis in mice by inducing FGF15 expression and reducing the hepatic pool of BA; this approach might be developed to reverse cholestasis in patients. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629701 Thu, 03 Nov 2011 04:00:00 +0100 5629701 http://www.medworm.com/index.php?rid=5629699&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015010%2Fabstract%3Frss%3Dyes Conclusions: The chemokine CCL17 is required for induction of intestinal inflammation in mice. CCL17 has an autocrine effect on DCs that promotes production of inflammatory cytokines and activation of Th1 and Th17 cells and reduces expansion of Treg cells. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629699 Thu, 03 Nov 2011 04:00:00 +0100 5629699 http://www.medworm.com/index.php?rid=5629698&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015046%2Fabstract%3Frss%3Dyes Conclusions: Aberrant type II NKT cell responses directly contribute to intestinal inflammation in mice, indicating the importance of CD1d expression levels in the development and regulation of type II NKT cells. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629698 Thu, 03 Nov 2011 04:00:00 +0100 5629698 http://www.medworm.com/index.php?rid=5525988&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015034%2Fabstract%3Frss%3Dyes Murine hepatocytes become polyploid and then undergo ploidy reversal and become aneuploid in a dynamic process called the ploidy conveyor. Although polyploidization occurs in some types of human cells, the degree of aneuploidy in human hepatocytes is not known. We isolated hepatocytes derived from healthy human liver samples and determined chromosome number and identity using traditional karyotyping and fluorescence in situ hybridization. Similar to murine hepatocytes, human hepatocytes are highly aneuploid. Moreover, imaging studies revealed multipolar spindles and chromosome segregation defects in dividing human hepatocytes. Aneuploidy therefore does not necessarily predispose liver cells to transformation but might promote genetic diversity among hepatocytes. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5525988 Thu, 03 Nov 2011 04:00:00 +0100 5525988 http://www.medworm.com/index.php?rid=5629703&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511015009%2Fabstract%3Frss%3Dyes Conclusions: PHLPP1 has tumor suppressive activity and might represent a therapeutic or diagnostic tool for PDAC. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629703 Mon, 31 Oct 2011 04:00:00 +0100 5629703 http://www.medworm.com/index.php?rid=5629696&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511014995%2Fabstract%3Frss%3Dyes Conclusions: In mice, claudin-7 has non-TJ functions, including maintenance of epithelial cell–matrix interactions and intestinal homeostasis. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5629696 Mon, 31 Oct 2011 04:00:00 +0100 5629696 http://www.medworm.com/index.php?rid=5526013&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511014983%2Fabstract%3Frss%3Dyes Pinier M, Verdu E, Nasser-Eddine M, et al. Suppression of gliadin-induced toxicity on the intestinal epithelium by polymeric binders. Gastroenterology 2009;136:288–298. In the paragraph entitled “Polymer-Gliadin Complexation,” (on page 289) an error has occurred in the units of P(HEMA-co-SS) and protein concentrations. The following sentence should correctly read: (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5526013 Mon, 31 Oct 2011 04:00:00 +0100 5526013 http://www.medworm.com/index.php?rid=5441924&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511013692%2Fabstract%3Frss%3Dyes In the July 2011 issue of Gastroenterology, Elashoff et al reported an increased incidence of pancreatitis in diabetic subjects undergoing glucagon-like peptide (GLP)-1–based therapies. In light of the recently emerging and proliferating discussion about the clinical use and the associated risks of incretin-based therapies, we would like to comment on this article and contribute evidence supporting the role of adipose-derived dipeptidyl peptidase (DPP)-4 in the context of the metabolic syndrome. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5441924 Mon, 31 Oct 2011 04:00:00 +0100 5441924 http://www.medworm.com/index.php?rid=5441889&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510018895%2Fabstract%3Frss%3Dyes Question: A 53-year-old woman with known celiac disease (CD) for 21 years, vitamin D deficiency, and osteoporosis was admitted with a 2-year history of weight loss, lethargy, and chronic watery diarrhea, which had become more marked in the last 6 months. She reported strict compliance with a gluten-free diet, although a detailed dietary history revealed she was inadvertently taking gluten in her diet in the form of breakfast cereal. On examination, she was malnourished (weight, 36 kg; body mass index, 13.7), with peripheral pitting edema and bilateral peripheral neuropathy to mid-shin level. Laboratory tests showed evidence of malabsorption with a microcytic anemia (hemoglobin, 9.5 g/dL; mean corpuscular volume, 75.9 fL) and reduced folate (2.1 μg/L), iron (3.3 μmol/L), calcium (2.0 mmol... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5441889 Mon, 31 Oct 2011 04:00:00 +0100 5441889 http://www.medworm.com/index.php?rid=5441885&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510015891%2Fabstract%3Frss%3Dyes Question: A 28-year-old woman living in a tropical country was admitted with severe upper abdominal pain in the epigastrium radiating to back requiring narcotic analgesics for relief for 5 days. There was no history of ethanol abuse or intake of drugs before the onset of symptoms. Biochemistry showed: hemoglobin, 10.4 gm%; total leukocyte count, 8,600 cells/mm3. The differential showed: polymorphs, 62; lymphocytes, 24; eosinophils, 12; blood urea, 26 mg/dL; serum creatinine, 0.8 mg/dL; blood sugar, 86 mg/dL; total bilirubin, 2.2 mg/dL; SGPT, 120 U/L (normal, 5–50); SGOT, 90 U/L (normal, 5–50); serum alkaline phosphatase; 290 U/L (normal, 25–125); serum amylase, 920 U/L (normal, 20–80); and serum lipase, 560 U/L (normal, 0–190). Abdominal ultrasonography revealed a normal gallblad... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5441885 Mon, 31 Oct 2011 04:00:00 +0100 5441885 http://www.medworm.com/index.php?rid=5441888&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510018858%2Fabstract%3Frss%3Dyes Question: A 51-year-old man presented with severe epigastric abdominal pain, an amylase of 171 U/L (normal, 25–115) and lipase of 3365 U/L (normal, 114–286). Computed tomography (CT) of the abdomen and pelvis demonstrated localized heterogenous hypoattenuation in the tail of the pancreas (TOP) with adjacent inflammatory changes consistent with acute pancreatitis with no evidence of gallbladder disease. He denied alcohol use, had a normal serum triglyceride level, and was treated conservatively for acute pancreatitis of unclear etiology. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5441888 Fri, 28 Oct 2011 04:00:00 +0100 5441888 http://www.medworm.com/index.php?rid=5441887&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510017348%2Fabstract%3Frss%3Dyes Question: An 86-year-old woman was referred to our surgery department because she had occult blood in her stool. A cecal mass was noted on colonoscopy. The cecal mucosa was grossly normal; however, biopsy showed mild inflammation and ulcer. Thus, a submucosal tumor with external compression of the cecal wall was suspected (). (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5441887 Fri, 28 Oct 2011 04:00:00 +0100 5441887 http://www.medworm.com/index.php?rid=5441886&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510018883%2Fabstract%3Frss%3Dyes Question: A 60-year-old, nonhypertensive, nondiabetic man presented with sudden onset of massive hematochezia and shock requiring multiple units of blood transfusion. There was no history of abdominal pain, vomiting, hematemesis, fever, or intake of nonsteroidal anti-inflammatory drugs preceding the onset of his symptoms. There was no history of similar episodes in the past. Biochemistry showed: hemoglobin, 5 g/dL; platelets, 130,000/mm3; blood urea, 72 mg/dL; serum creatinine, 0.8 mg/dL; blood sugar, 104 mg/dL; total bilirubin, 1.6 mg/dL; alanine aminotransferase, 30 U/L; aspartate aminotransferase, 38 U/L; and serum alkaline phosphatase, 80 U/L. Upper gastrointestinal endoscopy after 4 units of packed red cell transfusion revealed a blood clot in the second part of duodenum (). The appea... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5441886 Fri, 28 Oct 2011 04:00:00 +0100 5441886 http://www.medworm.com/index.php?rid=5441884&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510018937%2Fabstract%3Frss%3Dyes Question: A 64-year-old woman presented with signs of acute upper gastrointestinal bleeding characterized by 1 episode of hematemesis and stool mixed with dark blood. Her past medical and family history were unremarkable. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5441884 Fri, 28 Oct 2011 04:00:00 +0100 5441884 http://www.medworm.com/index.php?rid=5441881&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS001650851001735X%2Fabstract%3Frss%3Dyes Question: A 74-year-old man with cirrhosis (Child–Pugh class A, score 5) was admitted for treatment of a 4.5-cm hepatocellular carcinoma with combined radiofrequency ablation and drug-eluting beads transcatheter arterial chemoembolization (DEB-TACE). During the procedure, a 7-cm ablation was performed under ultrasound guidance followed by TACE using a total of 75 mg doxorubicin beads administered selectively into branches of the right and middle hepatic arteries. The next day, the patient complained of severe abdominal pain. Physical examination revealed tachycardia and generalized abdominal tenderness without rebound or guarding. Laboratory tests were as follows: Serum amylase, 1223 U/L (normal, 0–50); C-reactive protein, 120 mg/L (normal, 0–5); and lactate, 3 mmol/L (normal, 0.5–... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5441881 Fri, 28 Oct 2011 04:00:00 +0100 5441881 http://www.medworm.com/index.php?rid=5348810&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511013382%2Fabstract%3Frss%3Dyes Copyright Assignment. In consideration of the American Gastroenterological Association (AGA) Institute (the “AGA Institute”) taking action to review and credit the below-identified submission (the “Manuscript”), and for other valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned authors and/or creators (the “Authors”), jointly and severally, hereby transfer, convey, and assign to the AGA Institute, free and clear of any liens, licenses or encumbrances, the entire right, title, and interest in and to the Manuscript throughout the world, including without limitation in and to any and all copyrights for the Manuscript (including but not limited to rights to copy, publish, excerpt, collect royalties and make derivative works) in print,... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5348810 Wed, 26 Oct 2011 20:45:42 +0100 5348810 http://www.medworm.com/index.php?rid=5348809&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511013370%2Fabstract%3Frss%3Dyes Gastroenterology is the premiere journal in the field of gastrointestinal disease and is led by an internationally renowned board of editors. As the official journal of the AGA Institute, Gastroenterology delivers up-to-date and authoritative coverage of both basic and clinical gastroenterology and hepatology. Regular features include research and perspectives by leading authorities, reports on the latest technologies for diagnosing and treating digestive diseases, images illustrating important clinical findings, reviews of scholarly media, medical news, meeting summaries, video abstracts, and monthly podcasts. Gastroenterology also bridges the gap between basic and clinical science by publishing comprehensive reviews on important topics such as pancreatitis and liver disease. (Source: Gas... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5348809 Wed, 26 Oct 2011 20:45:42 +0100 5348809 http://www.medworm.com/index.php?rid=5348808&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511013369%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5348808 Wed, 26 Oct 2011 20:45:42 +0100 5348808 http://www.medworm.com/index.php?rid=5348807&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511013357%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5348807 Wed, 26 Oct 2011 20:45:42 +0100 5348807 http://www.medworm.com/index.php?rid=5348806&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511013333%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5348806 Wed, 26 Oct 2011 20:45:42 +0100 5348806 http://www.medworm.com/index.php?rid=5348784&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511007530%2Fabstract%3Frss%3Dyes Conclusions: Reduced levels of RA appear to induce IECs to up-regulate synthesis of RA. RA supplementation attenuates ileitis through its effects on CD103+ DCs, Tregs, and Th17 cells. RA supplementation might offer therapeutic benefit in Crohn's disease. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5348784 Wed, 26 Oct 2011 20:45:42 +0100 5348784 http://www.medworm.com/index.php?rid=5348739&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511012297%2Fabstract%3Frss%3Dyes It is with profound sadness that we note the unexpected passing of Dr Emmet B. Keeffe on August 8, 2011, at the age of 69. He passed away peacefully, after a sudden cerebral hemorrhage, surrounded by his loving family. Emmet is survived by his wife, Melenie; children, Emmet III (and his wife Deborah), Brian (and his wife Kristin), and Meghan (and her husband Simon); eight grandsons, Emmet IV, Mason, Miles, Ellis, Finley, Gilbert, Oscar, and Louis; and sisters, Lorelle Goold and Sharon Keeffe. His sister, Michele Donovan predeceased him. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5348739 Wed, 26 Oct 2011 20:45:42 +0100 5348739 http://www.medworm.com/index.php?rid=5441923&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511014326%2Fabstract%3Frss%3Dyes Gastroesophageal reflux disease (GERD), the most common esophageal disorder, affects approximately 40% of Americans on a weekly basis, and close to 10% daily or weekly (Am J Dig Dis 1976;21:953–956). Patients with esophageal disorders often turn to popular websites and other resources on the Internet to obtain information regarding their diagnosis and treatment options. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5441923 Wed, 26 Oct 2011 04:00:00 +0100 5441923 http://www.medworm.com/index.php?rid=5441921&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511014302%2Fabstract%3Frss%3Dyes Since the discovery less than 2 decades ago that nitric oxide is an endogenous gaseous signal molecule responsible for the control of cardiovascular, gastrointestinal, and nervous tissues, the study of gaseous signal molecules has increased greatly with active and expanding research on nitric oxide, carbon monoxide, and hydrogen sulfide, as well as emerging research on other gases. The clinical benefits of these researches have begun to be realized for nitric oxide and are emerging for other gases. Likewise, appreciation of the role of intestinal gas and the gas-producing microbiome to functional bowel disorders has increased in recent years. These broad areas of basic and clinical science to all aspects of biology are the focus of the new book entitled Gas Biology Research in Clinical Pra... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5441921 Wed, 26 Oct 2011 04:00:00 +0100 5441921 http://www.medworm.com/index.php?rid=5441920&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511013825%2Fabstract%3Frss%3Dyes Rubenstein JH, Scheiman JM, Sadeghi S, et al. Esophageal adenocarcinoma incidence in individuals with gastroesophageal reflux: synthesis and estimates from population studies. Am J Gastroenterol 2011;106:254–260. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5441920 Wed, 26 Oct 2011 04:00:00 +0100 5441920 http://www.medworm.com/index.php?rid=5441919&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511013813%2Fabstract%3Frss%3Dyes Wedemeyer H, Yurdaydin C, Dalekos GN, et al. Peginterferon plus Adefovir versus either drug alone for hepatitis delta. N Engl J Med 2011;364:322–331. The hepatitis delta virus (HDV), a small hepatotropic defective RNA virus that requires the presence of the hepatitis B virus (HBV) to replicate, is estimated to chronically infect more than 15 million carriers of HBV worldwide [J Hepatol 2003;39(Suppl 1):S212–219]. Composed of a coat of HBV envelope proteins surrounding the nucleocapsid, the virus consists of a single-stranded, circular RNA genome, which encodes 2 isoforms of a virus protein, the delta antigen. Because of its unique method of replication based on interaction between the surface antigen of HBV (HBsAg) with the protein-RNA complex of the virus, HDV has obtained its own ge... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5441919 Wed, 26 Oct 2011 04:00:00 +0100 5441919 http://www.medworm.com/index.php?rid=5441883&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510017324%2Fabstract%3Frss%3Dyes Question: A 60-year-old obese (body mass index of 50 kg/m2) woman was admitted through the emergency department with a history of severe colicky abdominal pain, abdominal distension, and constipation. She was known to have diverticular disease of sigmoid colon, hypertension, diabetes, and chronic obstructive pulmonary disease. There was no history of any previous abdominal operations. On examination, she was found to have distended abdomen with severe tenderness and guarding in the left iliac fossa. Her bowel sounds were increased. She had an elevated white cell count (18,000/mm3) and normal liver function tests. Her plain abdominal film showed large bowel dilatation with cutoff in the sigmoid colon. With the clinical impression of large bowel obstruction with possible acute diverticulitis... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5441883 Wed, 26 Oct 2011 04:00:00 +0100 5441883 http://www.medworm.com/index.php?rid=5441882&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510017361%2Fabstract%3Frss%3Dyes Question: A 73-year-old patient with myelodysplastic syndrome (-5q-syndrome) was treated with lenalidomide and later with a course with azacytdine. The patient now presented with abdominal pain and signs of intermittent intestinal obstruction. Colonoscopy 2 years before had been normal. Computed tomography was performed and revealed a large, obstructing tumor at the ileocecal valve. Colonoscopy revealed a round tumor 6 cm in diameter in the ascending colon involving the ileum ( A–B). Virtual chromoendoscopy using narrow-band imaging did not show any adenoma-like signs. An endoscopic biopsy was performed. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5441882 Wed, 26 Oct 2011 04:00:00 +0100 5441882 http://www.medworm.com/index.php?rid=5441880&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508510015908%2Fabstract%3Frss%3Dyes Question: A 53-year-old man was admitted with a week-long history of painless jaundice, pruritis, dark urine, and malaise. Examination revealed icterus, 1-cm hepatomegaly, gynecomastia, and shifting dullness. His blood tests were significant for markedly elevated liver function tests, low albumin, and prolonged prothrombin time. Abdominal computed tomography reported mild portal hypertension and ascites. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5441880 Wed, 26 Oct 2011 04:00:00 +0100 5441880 http://www.medworm.com/index.php?rid=5441879&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511014648%2Fabstract%3Frss%3Dyes See “Intra-acinar trypsinogen activation mediates early stages of pancreatic injury but not inflammation in mice with acute pancreatitis,” by Dawra R, Sah RP, Dudeja V, et al, on page 2210. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5441879 Wed, 26 Oct 2011 04:00:00 +0100 5441879 http://www.medworm.com/index.php?rid=5441878&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS001650851101465X%2Fabstract%3Frss%3Dyes See “Loss of caspase-8 protects mice against inflammation-related hepatocarcinogenesis but induces non-apoptotic liver injury,” by Liedtke C, Bangen JM, Freimuth J, et al, on page 2176. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5441878 Wed, 26 Oct 2011 04:00:00 +0100 5441878 http://www.medworm.com/index.php?rid=5441877&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511014624%2Fabstract%3Frss%3Dyes See “N-methyl d-aspartate channels link ammonia and epithelial cell death mechanisms in Helicobacter pylori infection,” by Seo JH, Fox JG, Peek Jr RM, et al, on page 2064. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5441877 Wed, 26 Oct 2011 04:00:00 +0100 5441877 http://www.medworm.com/index.php?rid=5441876&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511014636%2Fabstract%3Frss%3Dyes See “Efficacy of the protease inhibitor BI 201335, polymerase inhibitor BI 207127, and ribavirin in patients with chronic HCV infection,” by Zuezem S, Asselah T, Angus P, et al, on page 2047. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5441876 Wed, 26 Oct 2011 04:00:00 +0100 5441876 http://www.medworm.com/index.php?rid=5441873&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511014661%2Fabstract%3Frss%3Dyes It has been estimated that 10% of patients with gastroesophageal reflux develop Barrett's esophagus. Barrett's esophagus is a premalignant epithelial that increases the risk of developing adenocarcinoma by 30- to 125-fold, with a yearly incidence of approximately 0.5%. Approaches employed to reduce the risk of developing adenocarcinoma include regular surveillance and/or ablation of the Barrett's epithelia. An observational study recently published in this journal of Veterans Administration patients supported an effect by nonsteroidal anti-inflammatory drugs (NSAIDs) and statins in reducing the development of adenocarcinoma in patients with Barrett's esophagus (Gastroenterology 2010;138:2260–2266). (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5441873 Wed, 26 Oct 2011 04:00:00 +0100 5441873 http://www.medworm.com/index.php?rid=5526014&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511014612%2Fabstract%3Frss%3Dyes Deugnier Y, Turlin B, Ropert M, et al. Improvement in liver pathology of patients with β-thalassemia treated with deferasirox for at least 3 years. Gastroenterology 2011;141:1202–1211 (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5526014 Mon, 24 Oct 2011 04:00:00 +0100 5526014 http://www.medworm.com/index.php?rid=5441922&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511014314%2Fabstract%3Frss%3Dyes Reactive oxygen and nitrogen species can be products of normal cellular metabolism and have potentially beneficial effects (eg, cytotoxicity against invading bacteria). Because of the potential of these molecules also to damage normal tissue, the balance between pro-oxidants and antioxidants is critical for the survival and function of aerobic organisms. An imbalance favoring pro-oxidants and/or disfavoring antioxidants, potentially leading to damage, is defined as oxidative stress. For over 30 years, the Frontiers of Gastrointestinal Research series has published volumes, each with a selected topic of interest in gastrointestinal (GI) research and practice. The current volume (#29), focuses on the contribution and role of free radicals and oxidative stress in GI tract diseases; such a con... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5441922 Mon, 24 Oct 2011 04:00:00 +0100 5441922 http://www.medworm.com/index.php?rid=5441918&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511013801%2Fabstract%3Frss%3Dyes Eaton JE, Silveira MG, Pardi DS, et al. High-dose ursodeoxycholic acid is associated with the development of colorectal neoplasia in patients with ulcerative colitis and primary sclerosing cholangitis. Am J Gastroenterol 2011;106:1638–1645. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5441918 Mon, 24 Oct 2011 04:00:00 +0100 5441918 http://www.medworm.com/index.php?rid=5441874&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511013953%2Fabstract%3Frss%3Dyes What to recommend for colorectal cancer screening? The answer may seem obvious, elusive, or confusing, depending on your perspective (patient, gastroenterologist, primary care physician, public health specialist, or policy maker), but recent developments have called into question many of the relatively untested beliefs that underpin current guidelines. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5441874 Mon, 24 Oct 2011 04:00:00 +0100 5441874 http://www.medworm.com/index.php?rid=5441916&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511014041%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5441916 Fri, 21 Oct 2011 04:00:00 +0100 5441916 http://www.medworm.com/index.php?rid=5441915&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511014028%2Fabstract%3Frss%3Dyes (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5441915 Wed, 19 Oct 2011 04:00:00 +0100 5441915 http://www.medworm.com/index.php?rid=5441890&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511013898%2Fabstract%3Frss%3Dyes Imaging of the gastrointestinal (GI) tract largely relies on the inspection of the wall lining using optical endoscopy procedures or virtual endoscopic methods based on image analysis of radiologic approaches such as computed tomography. Other endoscopic methods of imaging have been also considered, including ultrasonography and optical tissue-sectioning microscopy methods. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5441890 Wed, 19 Oct 2011 04:00:00 +0100 5441890 http://www.medworm.com/index.php?rid=5441875&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511014004%2Fabstract%3Frss%3Dyes The National Institutes of Health (NIH), within the US Department of Health and Human Services, is the largest source of biomedical research support in the world. The NIH is composed of 27 Institutes and Centers (ICs), each with a specific mission reflected, at least partially, in its name. The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) supports basic, clinical, and behavioral research, research training, and public outreach in the fields of gastroenterology and hepatology, as well as in most other internal medicine subspecialties, including endocrinology and nephrology. Each NIH IC has its own menu of grant types for which applications are accepted. Choosing the appropriate type of grant for which to apply is critical when embarking on a research career. (Sou... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5441875 Wed, 19 Oct 2011 04:00:00 +0100 5441875 http://www.medworm.com/index.php?rid=5526001&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511013771%2Fabstract%3Frss%3Dyes Conclusions: Alterations in lipid metabolism contribute to the pathogenesis and progression of cholestatic liver disease in mice. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5526001 Mon, 17 Oct 2011 04:00:00 +0100 5526001 http://www.medworm.com/index.php?rid=5525991&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511013783%2Fabstract%3Frss%3Dyes Conclusions: Although there are few epidemiologic data from developing countries, the incidence and prevalence of IBD are increasing with time and in different regions around the world, indicating its emergence as a global disease. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5525991 Mon, 17 Oct 2011 04:00:00 +0100 5525991 http://www.medworm.com/index.php?rid=5525987&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS001650851101376X%2Fabstract%3Frss%3Dyes Tamoxifen, a selective estrogen receptor modulator, is widely used in research and clinically in patients. We find that treatment of normal mice with a single ≥3 mg/20 g body weight dose of tamoxifen leads to apoptosis of >90% of all gastric parietal cells (PCs) and metaplasia of zymogenic chief cells within 3 days. Remarkably, gastric histology returns to nearly normal by 3 weeks. Tamoxifen toxicity occurs by oral and intraperitoneal administration, in both sexes, in multiple strains, and does not depend on estrogen, though acid secretion inhibition is partially protective. Thus, substantial gastric toxicity is a heretofore unappreciated tamoxifen side effect. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5525987 Mon, 17 Oct 2011 04:00:00 +0100 5525987 http://www.medworm.com/index.php?rid=5441891&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511013795%2Fabstract%3Frss%3Dyes Inflammasomes are multi-protein complexes that mediate activation of caspase-1, which promotes secretion of the proinflammatory cytokines interleukin-1β and interleukin-18 and pyroptosis, a form of phagocyte cell death induced by bacterial pathogens. Members of the Nod-like receptor family (including Nlrp1, Nlrp3, and Nlrc4), the DNA sensor Aim2, the adaptor apoptosis-associated speck-like protein (ASC), and pro-caspase-1 are important components of inflammasomes. Stimulation with specific microbial and endogenous molecules leads to inflammasome assembly and caspase-1 activation. Inflammasomes are believed to mediate host defense against microbial pathogens and tissue homeostasis within the intestine, and their dysregulation might contribute to inflammatory diseases and intestinal cancer.... Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5441891 Mon, 17 Oct 2011 04:00:00 +0100 5441891 http://www.medworm.com/index.php?rid=5526002&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511013758%2Fabstract%3Frss%3Dyes Conclusions: Dietary cholesterol aggravates liver fibrosis because free cholesterol accumulates in HSCs, leading to increased TLR4 signaling, down-regulation of bone morphogenetic protein and activin membrane-bound inhibitor, and sensitization of HSC to TGFβ. This pathway might be targeted by antifibrotic therapies. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5526002 Wed, 12 Oct 2011 04:00:00 +0100 5526002 http://www.medworm.com/index.php?rid=5525994&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511013746%2Fabstract%3Frss%3Dyes Conclusions: Patients with CRC have a larger variance in germline levels of ASE in APC than controls; large distances from the mean ASE were associated with risk for common forms of CRC. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5525994 Wed, 12 Oct 2011 04:00:00 +0100 5525994 http://www.medworm.com/index.php?rid=5525990&cid=s_35582_17_f&fid=35582&url=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FPIIS0016508511013734%2Fabstract%3Frss%3Dyes Conclusions: The positive association with elective, but not emergency, cesarean delivery is consistent with the hypothesis that the bacterial flora of the newborn plays a role in the development of celiac disease. (Source: Gastroenterology) Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5525990 Wed, 12 Oct 2011 04:00:00 +0100 5525990