MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Growth Hormone and IGF Research' source. Thu, 11 Mar 2010 14:22:21 +0100 http://www.medworm.com/index.php?rid=3338808&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20199883%26dopt%3DAbstract CONCLUSIONS: Body fat was primarily located subcutaneously and metabolic consequences of obesity limited. The abnormal body composition similar to that in non-PWS GHD adults increases the interest of GH treatment in the prevention of obesity in adults with PWS. PMID: 20199883 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3338808 Tue, 02 Mar 2010 00:00:00 +0100 3338808 http://www.medworm.com/index.php?rid=3332049&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20194043%26dopt%3DAbstract CONCLUSION: These findings accentuate the importance of recognition of the clinical manifestations of arthropathy in patients with acromegaly despite long-term disease control. PMID: 20194043 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3332049 Sat, 27 Feb 2010 00:00:00 +0100 3332049 http://www.medworm.com/index.php?rid=3312740&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20185347%26dopt%3DAbstract CONCLUSIONS: Physiological GHR for at least 6months in hypopituitary adults with recently diagnosed severe GHD resulted in favourable changes in hs-CRP, WHR, fasting LDL-C and HDL-C levels all of which are recognised CV risk markers. However, there remains a high prevalence of obesity in this population and given the worsening of insulin sensitivity in the short term with GHR, monitoring and aggressive treatment of established CV risk factors is essential to reduce premature atherosclerotic CVD in this patient population. PMID: 20185347 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3312740 Tue, 23 Feb 2010 00:00:00 +0100 3312740 http://www.medworm.com/index.php?rid=3312739&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20185348%26dopt%3DAbstract CONCLUSIONS: These data indicate that IGF-I inhibited insulin activity in the 3T3-L1 adipocytes via ROS production, which affects IRS-1 phosphorylation status. PMID: 20185348 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3312739 Tue, 23 Feb 2010 00:00:00 +0100 3312739 http://www.medworm.com/index.php?rid=3306436&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20176498%26dopt%3DAbstract CONCLUSIONS: GH treatment significantly improved serum levels of IGF-I and body composition in a dose-responsive manner in Japanese AGHD patients. Total cholesterol and LDL-cholesterol levels also decreased. GH treatment was safe and generally well tolerated. PMID: 20176498 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3306436 Sat, 20 Feb 2010 00:00:00 +0100 3306436 http://www.medworm.com/index.php?rid=3270336&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20149700%26dopt%3DAbstract CONCLUSIONS: In addition to an association with catch-up growth, GHR exon 3 genotype significantly modulates HbA1c and IGFBP-1 concentrations in former ELBW infants. In order to confirm this observation and to clarify whether the GHRd3-variant might be considered as an independent modulator of the low birth weight infant's risk to develop insulin resistance later in life, larger studies extending to later ages are required. PMID: 20149700 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3270336 Mon, 08 Feb 2010 00:00:00 +0100 3270336 http://www.medworm.com/index.php?rid=3264473&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20144555%26dopt%3DAbstract Authors: Phang D, Rehage M, Bonafede B, Hou D, Xing W, Mohan S, Wergedal JE, Qin X In vivo studies have provided ubiquitous evidence that pregnancy-associated plasma protein-A (PAPP-A) functions as a potent anabolic factor. While some evidence supports the prediction that increasing IGF bioavailability contributes to the anabolic effects of PAPP-A, definitive evidence has been lacking. This important issue has been addressed in this study using a unique mouse model in which PAPP-A was overexpressed in bone either alone or together with a protease-resistant IGFBP-4 analog (PRBP-4) which serves as an IGF inhibitor. PAPP-A transgenic mice exhibited a 25% increase in skull bone mineral density (BMD) whereas PRBP-4 transgenic mice showed a 20-25% decrease in this parameter at an age of 3mon... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3264473 Sat, 06 Feb 2010 00:00:00 +0100 3264473 http://www.medworm.com/index.php?rid=3221445&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20110184%26dopt%3DAbstract CONCLUSION: Serum IGF-II/M6P-R is up-regulated in morbid obesity, down-regulated by weight loss and elevated in moderately obese T2D. However, although plasma IGF-II was also reduced following GB, the two peptides were not statistically correlated. No acute effect of insulin was seen. These findings indicate that the IGF-II/M6P-R is nutritionally regulated, independently of IGF-II. PMID: 20110184 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3221445 Tue, 26 Jan 2010 00:00:00 +0100 3221445 http://www.medworm.com/index.php?rid=3221446&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20106687%26dopt%3DAbstract Authors: David Åberg N, Lind J, Isgaard J, Georg Kuhn H Growth hormone (GH) and insulin-like growth factor I (IGF-I) increase cell genesis in several regions of the brains of GH-IGF-I-deficient hypophysectomized rats. However, it is not known to what degree GH treatment stimulates adult cell genesis in pituitary-intact rodents. We investigated the effect of peripheral administration of bovine growth hormone (bGH) on cellular proliferation in various regions of the brains of normal adult female rats. To monitor cell division, bromodeoxyuridine (BrdU) was administered daily for 5days. We studied the two areas of ongoing neurogenesis, the subventricular zone (SVZ) and the dentate gyrus (DG) of the hippocampus, as well as the corpus callosum, striatum, and the parietal and piriform co... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3221446 Mon, 25 Jan 2010 00:00:00 +0100 3221446 http://www.medworm.com/index.php?rid=3198237&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20089431%26dopt%3DAbstract Conclusions: IGF-II and the anti-apoptotic proteins differential expression among AA and CA patients may contribute to the breast cancer survival disparities observed between these ethnic groups. PMID: 20089431 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3198237 Tue, 19 Jan 2010 00:00:00 +0100 3198237 http://www.medworm.com/index.php?rid=3167534&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20060348%26dopt%3DAbstract CONCLUSION: In rats with aortic stenosis-induced heart failure, growth hormone administration increases MyoD gene expression above non-treated animal levels, preserves muscular trophism and attenuates interstitial fibrosis. These results suggest that growth hormone may have a potential role as an adjuvant therapy for chronic heart failure. PMID: 20060348 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3167534 Wed, 06 Jan 2010 00:00:00 +0100 3167534 http://www.medworm.com/index.php?rid=3136236&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20044290%26dopt%3DAbstract Authors: Lioi SA, Rigalli A, Puche RC The intravenous administration of rhGH (recombinant human Growth Hormone) to fasting female rats causes an increase in the rate of synthesis and secretion of VLDL (very low density lipoproteins). This phenomenon has three striking characteristics: (1) the demonstration of an unexpected lipogenic effect of rhGH, (2) its rapid occurrence after intravenous injection of the hormone and (3) the apparent dependence on the levels of circulating estrogens, as deduced by the lack of effect of rhGH on males and castrated females. The target tissue for the lipogenic effect was traced to the intestine by means of perfusion experiments of isolated duodenal loops. Impairment of liver blood supply discarded this tissue as the source of VLDL induced by rhGH. After... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3136236 Tue, 29 Dec 2009 00:00:00 +0100 3136236 http://www.medworm.com/index.php?rid=3136235&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20044291%26dopt%3DAbstract CONCLUSION: Despite marginal reductions in total IGF-I and -II, bioactive and free IGF-I declined markedly during and after HD. This is likely a consequence of the increase in IGFBP-1, sequestering free IGF-I, and reducing bioactive IGF-I. Based on the present data we hypothesize that the catabolism induced by HD is in part related to the observed reductions in bioactive IGF-I. PMID: 20044291 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3136235 Tue, 29 Dec 2009 00:00:00 +0100 3136235 http://www.medworm.com/index.php?rid=3120963&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20031461%26dopt%3DAbstract Authors: Suetta C, Clemmensen C, Andersen JL, Magnusson SP, Schjerling P, Kjaer M Hypertrophy of developing skeletal muscle involves stimulation by insulin-like growth factor-I (IGF-I), however, the role of IGF-I in adult muscle is less clarified. In the present study, the mRNA splice variants of IGF-I (IGF-IEa and MGF) and the changes in muscle fiber cross sectional area after 12weeks of training were studied in elderly post-operative patients. About 28 subjects, 14 men and 14 women (age 69, range 60-86 years) were randomized to unilateral resistance training (RT: 3/week), electrical stimulation (ES: 1h/day) or functional exercises (FE: 1h/day). The non-operated-side served as a within subject control. Muscle biopsies were obtained from the vastus lateralis of both limbs at +2d post-o... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3120963 Mon, 21 Dec 2009 00:00:00 +0100 3120963 http://www.medworm.com/index.php?rid=3108808&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20022776%26dopt%3DAbstract Authors: Myrelid A, Frisk P, Stridsberg M, Annerén G, Gustafsson J Down syndrome (DS) is associated with short stature and obesity. Adults with DS have several features in common with growth hormone (GH) deficient adult subjects. The aim of this study was to investigate GH secretion in young adults with DS and its relation to body composition as well as glucose and lipid metabolism. Ten young adults with DS (aged 24-32years; 5 F) and ten controls matched for age and sex were examined regarding spontaneous nocturnal GH secretion and body composition. Stable isotope tracers were used to study glucose and lipid metabolism in the DS subjects. There was no difference in secretion of GH between the DS subjects and controls. The DS subjects had a higher BMI, fat mass proportion and HOMA ... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3108808 Fri, 18 Dec 2009 00:00:00 +0100 3108808 http://www.medworm.com/index.php?rid=3108809&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20022531%26dopt%3DAbstract CONCLUSION: These results show that several components of the main GH-signaling pathways exhibit enhanced sensitivity to the hormone in liver and muscle of Ames dwarf mice. PMID: 20022531 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3108809 Thu, 17 Dec 2009 00:00:00 +0100 3108809 http://www.medworm.com/index.php?rid=3101281&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20005140%26dopt%3DAbstract CONCLUSION: A low IGF-I level is associated with hypercapnia presumably by reducing ventilatory drive and favouring muscle weakness. The relationship between increased triglycerides and low IGF-I may represent one of mechanisms involved in the OHS increased cardio-vascular risk. PMID: 20005140 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3101281 Thu, 10 Dec 2009 00:00:00 +0100 3101281 http://www.medworm.com/index.php?rid=3068076&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19962924%26dopt%3DAbstract In this study we demonstrated that IGF-II (1-87), as an abundant "big" IGF-II form, exists at a molar ratio of 0.24 (CI 0.13-0.62) with respect to mature IGF-II in the normal human circulation. Mature and "big" IGF-II can equally form complexes with IGFBP-2 and IGFBP-3 in vitro, resulting in the inhibition of IGF-II's biological function. However, under physiological conditions which entails the presence of both "big" and mature IGF-II, "big" IGF-IIs preferably formed complexes with IGFBP-3 but not IGFBP-2, unlike mature IGF-II which was equally associated with both IGFBP-3 and IGFBP-2. "Big" IGF-II binding to IGFBP-2 was only evident when the "big"/mature IGF-II ratio approached 1 or higher. We concluded that mature IGF-II prevents the formation of "big" IGF-II/IGFBP-2 complex in the circ... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3068076 Thu, 03 Dec 2009 00:00:00 +0100 3068076 http://www.medworm.com/index.php?rid=3052880&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19945319%26dopt%3DAbstract Authors: Interlichia JP, Williams NG, Rodgers BD One of the most accurate indices of changes in somatic tissue growth rate in rodents is the width of tibial epiphyseal plates as unlike most mammals, rodent growth plates never ossify. Unfortunately, the original procedure to measure tibial epiphyseal plate width (TEPW) was developed for rats and yields poor results with mice. This paper demonstrates a simple method for silver staining growth plates that can be used to inexpensively and quickly measure the TEPW of mice. Poor visualization due to overstaining and the shattering of growth plates necessitated several revisions to the original protocol. These include exposing the growth plate prior to acetone dehydration, reducing the silver nitrate concentration from 2% to 1.5% and staining... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3052880 Thu, 26 Nov 2009 00:00:00 +0100 3052880 http://www.medworm.com/index.php?rid=3027322&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19932628%26dopt%3DAbstract We examined the relationships between RA-induced protein kinase C (PKC)-delta, the secretion and synthesis of IGF-I, and oxidative stress. RA at 10(-8)M and 10(-7)M increased PKC-delta phosphorylation (the ratio of phosphorylated to total PKC-delta) (p<0.05) and decreased the secretion and synthesis of IGF-I (p<0.05) compared to control, with the effects peaking for treatment with 10(-7)M RA for 72h. The silencing of PKC-delta prevented the RA-induced inhibition of the secretion and synthesis of IGF-I and cell viability (p<0.05). Application of 10(-7)M RA for 72h increased the level of thiobarbituric-acid-reactive substances and the expression of inducible nitric oxide synthase relative to control (p<0.05). These increases were blocked by suppressing PKC-delta and by pretreatme... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3027322 Fri, 20 Nov 2009 00:00:00 +0100 3027322 http://www.medworm.com/index.php?rid=3027321&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19932629%26dopt%3DAbstract CONCLUSIONS: IGF-1 and IGFBP-3 levels seem to be independent of renal function and severity of proteinuria. However, ALS levels are altered in renal failure and nephrotic syndrome, which may be due to increased renal loss or diminished hepatic production or both. PMID: 19932629 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3027321 Fri, 20 Nov 2009 00:00:00 +0100 3027321 http://www.medworm.com/index.php?rid=2963794&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19884028%26dopt%3DAbstract CONCLUSIONS: Our study confirmed that acromegalic patients have an increased proportion of circulating 20kDa-hGH isoform. Consequently, the use of a 22kDa-hGH specific assay may underestimate the tumor production of total GH. Although octreotide LAR promoted a significant decrease in the GH and IGF-I levels, it did not normalize the GH isoforms composition and suggests that the secretion of GH isoforms is equally inhibited by somatostatin analogues and that it is the disease control that normalizes the GH isoforms composition in acromegaly. PMID: 19884028 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2963794 Sat, 31 Oct 2009 00:00:00 +0100 2963794 http://www.medworm.com/index.php?rid=2931558&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19853487%26dopt%3DAbstract In this study, we investigated the relationship between pomegranate-induced apoptosis in human prostate cancer cells and the IGF/IGFBP system. Treatment of LAPC4 prostate cancer cells with 10mug/ml POMx, a highly potent pomegranate extract prepared from skin and arils minus seeds and standardized to ellagitannin content (37% punicalagins by HPLC), resulted in inhibition of cell proliferation and induction of apoptosis. Interestingly, co-treatment with POMx and IGFBP-3 revealed synergistic stimulation of apoptosis and additive inhibition of cell growth. Western blot analysis revealed that treatment with POMx or POMx/IGFBP-3 combination resulted in increased JNK phosphorylation, and decreased Akt and mTOR activation, consistent with a growth inhibitory, pro-apoptotic function. We also invest... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2931558 Wed, 21 Oct 2009 00:00:00 +0100 2931558 http://www.medworm.com/index.php?rid=2891521&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19818658%26dopt%3DAbstract Authors: Frystyk J, Freda P, Clemmons DR For almost three decades, the measurement of circulating IGF-I has constituted a highly important biochemical tool in the management of GH disorders. In fact, in acromegaly the importance of circulating IGF-I has increased following the introduction of the GH receptor antagonist pegvisomant, as the use of this drug makes it impossible to use circulating GH as a monitor of disease activity. In addition, determination of circulating IGF-I constitutes a valuable scientific tool in various research areas, from epidemiological investigations through clinical trials and experimental studies. The multiple facets of IGF-I physiology and patho-physiology may explain why numerous endocrine laboratories have invested in IGF-I assays, by means of either in-... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2891521 Tue, 06 Oct 2009 23:00:00 +0100 2891521 http://www.medworm.com/index.php?rid=2891520&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19818659%26dopt%3DAbstract Authors: Bidlingmaier M, Freda PU Measuring the concentration of growth hormone (GH) in blood samples taken during dynamic tests represents the basis for diagnosis of growth hormone related disorders, namely growth hormone deficiency and growth hormone excess. Today, a wide spectrum of immunoassays are in use, enabling rapid and sensitive determination of growth hormone concentrations in routine diagnostics. From a clinical point of view several difficulties exist with the use and interpretation of GH assay results in the assessment of GH related disorders: Many physiological factors such as fat mass, age and gender influence the outcome of dynamic tests, overall leading to significant inter-individual differences in GH responses. However, in addition to the physiological variability, ... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2891520 Tue, 06 Oct 2009 23:00:00 +0100 2891520 http://www.medworm.com/index.php?rid=2866489&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19800825%26dopt%3DAbstract CONCLUSION: The increased number of BrdU-positive cells in the granule cell layer suggests a partial restoration in the pool of proliferating cells by hexarelin after IR. PMID: 19800825 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2866489 Wed, 30 Sep 2009 23:00:00 +0100 2866489 http://www.medworm.com/index.php?rid=2866490&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19800274%26dopt%3DAbstract Authors: Vijayakumar A, Novosyadlyy R, Wu Y, Yakar S, Leroith D This review will summarize the metabolic effects of growth hormone (GH) on the adipose tissue, liver, and skeletal muscle with focus on lipid and carbohydrate metabolism. The metabolic effects of GH predominantly involve the stimulation of lipolysis in the adipose tissue resulting in an increased flux of free fatty acids (FFAs) into the circulation. In the muscle and liver, GH stimulates triglyceride (TG) uptake, by enhancing lipoprotein lipase (LPL) expression, and its subsequent storage. The effects of GH on carbohydrate metabolism are more complicated and may be mediated indirectly via the antagonism of insulin action. Furthermore, GH has a net anabolic effect on protein metabolism although the molecular mechanisms of i... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2866490 Tue, 29 Sep 2009 23:00:00 +0100 2866490 http://www.medworm.com/index.php?rid=2801124&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19747867%26dopt%3DAbstract Authors: Longo KA, Berryman DE, Kelder B, Charoenthongtrakul S, Distefano PS, Geddes BJ, Kopchick JJ The goal of this study was to examine factors that contribute to energy balance in female GHR -/- mice. We measured energy intake, energy expenditure (EE), fuel utilization, body mass (M(b)) changes and physical activity in 17month-old female GHR -/- mice and their age-matched wild type littermates. The GHR -/- mice were smaller, consumed more food per unit M(b), had greater EE per unit M(b) and had an increase in 24-h EE/M(b) that was similar to the increase in their surface-area-to-volume ratio. Locomotor activity (LMA) was reduced in the GHR -/- mice, but the energetic cost associated with their LMA was greater than in wild type controls. Furthermore, M(b) and LMA were independent ex... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2801124 Tue, 08 Sep 2009 23:00:00 +0100 2801124 http://www.medworm.com/index.php?rid=2738446&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19703789%26dopt%3DAbstract CONCLUSIONS: In summary, we provide evidence that E2F1 regulates IGF-IR gene transcription in prostate cancer cells via a mechanism that involves direct binding to specific elements in the proximal IGF-IR promoter. PMID: 19703789 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2738446 Fri, 21 Aug 2009 23:00:00 +0100 2738446 http://www.medworm.com/index.php?rid=2731002&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19699127%26dopt%3DAbstract CONCLUSION: These findings suggest that OC-DDTs could modulate the IGF-system in a way that is highly influenced by gender and age. Improvements in our understanding of exogenous determinants of the IGF-system may provide new insights into the role played by environmental contaminants in IGF-related diseases. PMID: 19699127 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2731002 Tue, 18 Aug 2009 23:00:00 +0100 2731002 http://www.medworm.com/index.php?rid=2725632&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19695914%26dopt%3DAbstract CONCLUSION: The data suggest male and female fetuses institute different strategies in response to adverse pregnancy conditions such as asthma and cigarette use. PMID: 19695914 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2725632 Mon, 17 Aug 2009 23:00:00 +0100 2725632 http://www.medworm.com/index.php?rid=2700475&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19674922%26dopt%3DAbstract CONCLUSIONS: These results provide evidence for an involvement of PGs in the regulation of growth as well as the GH-IGF and HPA axes. Therefore, early postnatal exposure to PG inhibitors may further exacerbate postnatal growth restriction and ability to cope with stress. PMID: 19674922 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2700475 Sun, 09 Aug 2009 23:00:00 +0100 2700475 http://www.medworm.com/index.php?rid=2684011&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19660970%26dopt%3DAbstract CONCLUSION: Short time discontinuation of HRT in young hypopituitary women increased liver enzymes, whereas measures of insulin sensitivity and lipid levels remained unchanged. We speculate that the estrogen component of HRT has beneficial effects on hepatic metabolism through various pathways. Further studies including liver imaging and with a time-dependent design are needed to clarify the role of HRT on liver enzyme levels, metabolic variables and liver fat content. PMID: 19660970 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2684011 Mon, 03 Aug 2009 23:00:00 +0100 2684011 http://www.medworm.com/index.php?rid=2679123&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19656700%26dopt%3DAbstract CONCLUSIONS: This study demonstrates that TGF-beta1 modulates the expression of IGFBP-4 and PAPP-A in cultured periosteal explants. PMID: 19656700 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2679123 Sun, 02 Aug 2009 23:00:00 +0100 2679123 http://www.medworm.com/index.php?rid=2622702&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19615927%26dopt%3DAbstract CONCLUSION: GH modulates the development of acute pancreatitis in the presence of active sensory nerves probably via stimulation of IGF-1 release. PMID: 19615927 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2622702 Tue, 14 Jul 2009 23:00:00 +0100 2622702 http://www.medworm.com/index.php?rid=2615820&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19608446%26dopt%3DAbstract This article provides an overview of legal considerations in anti-doping procedures that may apply to the use of the marker method for the detection of Human Growth Hormone. In cases where the blood markers IGF-1 and P-III-P indicate use of exogenous growth hormone, reference to positivity criteria and laboratory uncertainty measurements would assist anti-doping adjudicative bodies in concluding, to their comfortable satisfaction, that a positive test has been established. Use of established positivity criteria and laboratory uncertainty measurements place the application of the marker method for growth hormone within the existing, accepted legal framework for evaluating an Adverse Analytical Finding. PMID: 19608446 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Re... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2615820 Mon, 13 Jul 2009 23:00:00 +0100 2615820 http://www.medworm.com/index.php?rid=2570462&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19574074%26dopt%3DAbstract Authors: Cowan DA, Bartlett C Two important biomarkers for the identification of growth hormone or IGF-I administration are IGF-I and P-III-P. These substances are determined in plasma or preferably in serum. There are a number of assays on the market for IGF-I but only two for P-III-P. The principles behind these assays and the choice of assays for doping control purposes are discussed. The future possibility of quantification by mass spectrometry is also briefly discussed. PMID: 19574074 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2570462 Mon, 29 Jun 2009 23:00:00 +0100 2570462 http://www.medworm.com/index.php?rid=2561714&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19560381%26dopt%3DAbstract CONCLUSION: These results contribute to a better understanding of metabolic glycemic disorders in HIV-1-infected pregnant women using ARV, showing that IGF-2/ApaI polymorphisms are not responsible as a single causative factor of glycemic alterations. These data indicate that other variables should be studied in order to explain these glycemic abnormalities. PMID: 19560381 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2561714 Wed, 24 Jun 2009 23:00:00 +0100 2561714 http://www.medworm.com/index.php?rid=2532939&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19535276%26dopt%3DAbstract GH & IGF Research issue on doping with growth hormone. Growth Horm IGF Res. 2009 Jun 16; Authors: Sonksen PH, Holt RI PMID: 19535276 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532939 Mon, 15 Jun 2009 23:00:00 +0100 2532939 http://www.medworm.com/index.php?rid=2532937&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19539504%26dopt%3DAbstract Authors: Pinsent M PMID: 19539504 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532937 Mon, 15 Jun 2009 23:00:00 +0100 2532937 http://www.medworm.com/index.php?rid=2532935&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19539505%26dopt%3DAbstract Authors: Graham MR, Baker JS, Evans P, Hullin D, Thomas NE, Davies B Athletes have enjoyed almost a thirty year amnesty of rhGH abuse, which they consider has contributed to the winning of medals and the breaking of world records. Such a reprieve is almost at an end, since WADA have identified a method to detect rhGH abuse. Or have they? The anecdotal word "on the street" is that rhGH is still undetectable and athletes believe that the benefits, at the dosages they administer, far outweigh the risks! Scientists are aware that in a hormone deficiency condition, replacement can halt and in certain situations reverse some of the adverse effects. Growth hormone deficiency can lead to a loss of skeletal muscle mass and an increase in abdomino-visceral obesity, which is reversed on replaceme... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532935 Mon, 15 Jun 2009 23:00:00 +0100 2532935 http://www.medworm.com/index.php?rid=2532933&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19539506%26dopt%3DAbstract CONCLUSIONS: Specific cleavage of IGFBP-1 occurs at the tissue level and not in the circulation in a patient with multiple myeloma and dermatitis. The fragments that are generated may have endocrine roles. PMID: 19539506 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532933 Mon, 15 Jun 2009 23:00:00 +0100 2532933 http://www.medworm.com/index.php?rid=2532941&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19524466%26dopt%3DAbstract CONCLUSION: These results indicate a novel role for GH and its receptor in injury-induced neurogenesis, and suggest that GH treatment may potentiate endogenous neuro-restorative processes after brain injury. PMID: 19524466 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532941 Wed, 10 Jun 2009 23:00:00 +0100 2532941 http://www.medworm.com/index.php?rid=2532943&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19515593%26dopt%3DAbstract Authors: Bassett EE, Erotokritou-Mulligan I The detection of growth hormone (GH) abuse by athletes raises statistical problems as well as biochemical ones. We outline the statistical approaches to the various issues which have arisen during the work of the GH-2000 and GH-2004 teams; in particular, it considers the need to develop a test which detects GH abuse in any elite athlete 'beyond reasonable doubt'. The test needs to be robust enough to withstand legal challenge, while minimising the risk of false accusation. The paper identifies various issues which arise in the development of such a test, and describes how these were resolved. Since GH is a naturally occurring hormone whose concentration varies substantially, its abuse cannot be detected by direct measurement. The methodology ... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532943 Sun, 07 Jun 2009 23:00:00 +0100 2532943 http://www.medworm.com/index.php?rid=2532947&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19502089%26dopt%3DAbstract Authors: Sharp RJ PMID: 19502089 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532947 Fri, 05 Jun 2009 23:00:00 +0100 2532947 http://www.medworm.com/index.php?rid=2532945&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19505835%26dopt%3DAbstract Authors: Widdowson WM, Healy ML, Sönksen PH, Gibney J The growth hormone (GH)/ insulin-like growth factor-I (IGF-I) axis exerts short-and long-term metabolic effects that are potentially important during exercise. Exercise is a potent stimulus to GH release and there is some evidence that the acute increase in GH is important in regulating substrate metabolism post-exercise. Regular exercise also increases 24-hour GH secretion rates, which potentially contributes to the physiologic changes induced by training. The effects of GH replacement in GH-deficient adults provide a useful model with which to study the effects of the more long-term effects of the GH/ IGF-I axis. There is convincing evidence that GH replacement increases exercise capacity. Measures of exercise performance inc... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532945 Fri, 05 Jun 2009 23:00:00 +0100 2532945 http://www.medworm.com/index.php?rid=2532949&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19501005%26dopt%3DAbstract Authors: Goodbody J PMID: 19501005 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532949 Wed, 03 Jun 2009 23:00:00 +0100 2532949 http://www.medworm.com/index.php?rid=2532951&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19501004%26dopt%3DAbstract Authors: Ding J, List EO, Okada S, Kopchick JJ Several serum biomarkers for recombinant human growth hormone (rhGH) have been established, however, none alone or in combination have generate a specific, sensitive, and reproducible 'kit' for the detection of rhGH abuse. Thus, the search for additional GH specific biomarkers continues. In this review, we focus on the use of proteomics in general and two-dimensional electrophoresis (2-DE) in particular for the discovery of new GH induced serum biomarkers. Also, we review some of the protocols involved in 2-DE. Finally, the possibility of tissues other than blood for biomarker discovery is discussed. PMID: 19501004 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532951 Tue, 02 Jun 2009 23:00:00 +0100 2532951 http://www.medworm.com/index.php?rid=2532957&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19487144%26dopt%3DAbstract CONCLUSIONS: In 2008 significant progress has been made; there is one test for detecting HGH approved for use in anti-doping and a second detection method pending. This is a strong reflection of the ongoing research efforts in anti-doping and the progress being made by the Anti-Doping Organisations in reducing the risk that doping poses to sport. PMID: 19487144 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532957 Fri, 29 May 2009 23:00:00 +0100 2532957 http://www.medworm.com/index.php?rid=2532956&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19487145%26dopt%3DAbstract In this report, we review studies of its biological effect, measurement and secretion. To use serum 20K-GH level in detecting GH abuse, new method has been established and serum 22K-GH, 20K-GH were measured in normal subjects and athletes, and no abnormal results were found among athletes. Another study confirmed that serum 22K-GH increased remarkably and 20K-GH decreased following the exogenous administration of 22K-GH. The duration was relatively short, approximately 24-36h in our and other studies. The increase of the ratio, 22K-GH/20K-GH was the most suitable indicator of GH abuse. Studies supported by the WADA were undertaken in collaboration with an Australian Group. A new approach for the GH isoform assay by beads assay platform is being developed. It is concluded that the direct me... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532956 Fri, 29 May 2009 23:00:00 +0100 2532956 http://www.medworm.com/index.php?rid=2532955&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19487146%26dopt%3DAbstract Authors: Rogol AD There is great interest among athletes and in the sports and general media for the subject of "doping" with human growth hormone (hGH). The hype about this substance goes far beyond the available data. The issue of administration of recombinant rhGH to adolescents, whether for athletic performance or for esthetic purposes adds another wrinkle because normal pubertal growth and the acquisition of adult body composition depends upon the GH/IGF-I and the hypothalamic-pituitary-gonadal axes. The range of normal is wide and it is more difficult to determine the natural evolution of pubertal development from that fueled by rhGH (or anabolic steroids). There are no compelling data based on clinical trials to indicate enhanced athletic performance (young adults); however, one... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532955 Fri, 29 May 2009 23:00:00 +0100 2532955 http://www.medworm.com/index.php?rid=2532953&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19487147%26dopt%3DAbstract Authors: Harridge SD, Velloso CP Gene doping is the term given to the potential misuse of gene therapy for the purposes of enhancing athletic performance. Insulin like growth factor-I (IGF-I), the prime target of growth hormone action, is one candidate gene for improving performance. In recent years a number of transgenic and somatic gene transfer studies on animals have shown that upregulation of IGF-I stimulates muscle growth and improves function. This increase in muscle IGF-I is not reflected in measurable increases in circulating IGF-I. Whilst the responses obtained in the animal studies would appear to give clear benefits for performance, the transfer of such techniques to humans still presents many technical challenges. Further challenges will also be faced by the anti doping au... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532953 Fri, 29 May 2009 23:00:00 +0100 2532953 http://www.medworm.com/index.php?rid=2532958&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19482501%26dopt%3DAbstract Authors: Barroso O, Schamasch P, Rabin O Due to its considered performance enhancing effects, human growth hormone (hGH) is abused as a doping agent in sport. Its misuse also carries potentially serious side effects to a person's health. Consequently, hGH and its releasing factors are prohibited in sport, as established in the Prohibited List which is updated and published yearly by the World Anti-Doping Agency (WADA). In order to fight the menace that hGH doping poses to the spirit of sport and to the health of athletes, the sport movement and the anti-doping authorities, initially led by the International Olympic Committee (IOC) and later by WADA, have put substantial efforts into developing tests for its detection. Currently, a primary analytical approach, the isoform differential i... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532958 Thu, 28 May 2009 23:00:00 +0100 2532958 http://www.medworm.com/index.php?rid=2532959&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19481485%26dopt%3DAbstract In conclusion, age and gender are the major determinants of variability for IGF-I and the collagen markers, whereas ethnicity and sport type have a minor influence. Therefore, a test based on IGF-I and the collagen markers must take age into account for men and women, and ethnicity and sport type are unlikely to be confounders for these markers. PMID: 19481485 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532959 Tue, 26 May 2009 23:00:00 +0100 2532959 http://www.medworm.com/index.php?rid=2532960&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19477668%26dopt%3DAbstract Authors: Ehrnborg C, Rosén T Drugs and methods to improve physical performance among athletes have been used since the beginning of sport history, but the use of performance enhancing drugs has not always been regarded as cheating. In short, the motives for doping are improving and maintaining physical functioning, coping with the social/psychological pressures and striving for social and psychological goals, including economic benefits. Factors such as, "doping dilemma", "win at all costs", cost versus benefit, and the specificity of some specific doping agents, also play major roles. It seems that action on the athletes' attitude about the achievement of physical improvement and creating effective methods to reveal the drug abuse, are two main ways in winning the struggle agains... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532960 Mon, 25 May 2009 23:00:00 +0100 2532960 http://www.medworm.com/index.php?rid=2532962&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19473863%26dopt%3DAbstract Authors: Gutiérrez-Gallego R, Bosch J, Such-Sanmartín G, Segura J Human growth hormone (GH) represents an extremely challenging task from an anti-doping viewpoint. GH is an endogenously produced substance, present at very low levels in circulation (for the most abundant 22kDa isoform approximately 50pM in plasma and 100fM in urine) either as monomer or homo- and heterodimers, comprises a family of distinct isoforms, and obeys a pulsatile secretion routine that is affected by many different internal and external factors. Upon administration of the recombinant, single-isoform pharmaceutical, the feedback mechanism reduces the endogenous heterogeneity resulting in altered ratios between the different GH isoforms. Thus, measuring the isoform ratios through immuno assays appears t... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532962 Sun, 24 May 2009 23:00:00 +0100 2532962 http://www.medworm.com/index.php?rid=2532961&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19473864%26dopt%3DAbstract Authors: Sonksen P The IOC recognised growth hormone (GH) as a drug of abuse in 1992 and recruited me as an expert to advise them on the development of a test to detect its abuse. After a long gestation period where the IOC gradually changed their attitude to research they co-funded the GH-2000 project with the European Union (EU). GH-2000 was a unique consortium of Europe's best endocrinologists and scientists in partnership with two GH manufacturers and the IOC with a greater than two million dollar budget. GH-2000 selected a method based on the measurement of GH-dependent markers and selected IGF-I and P-III-P as the most suitable markers and demonstrated that they could detect 100% of men taking GH with a false-positive rate better than 1:10,000; sensitivity was reduced however in ... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532961 Sun, 24 May 2009 23:00:00 +0100 2532961 http://www.medworm.com/index.php?rid=2532966&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19467614%26dopt%3DAbstract Authors: Baumann GP Human growth hormone (GH) is a heterogeneous protein hormone consisting of several isoforms. The sources of this heterogeneity reside at the level of the genome, mRNA splicing, post-translational modification and metabolism. The GH gene cluster on chromosome 17q contains 2 GH genes (GH1 or GH-N and GH2 or GH-V) in addition to 2(-3) genes encoding the related chorionic somatomammotropin. Alternative mRNA splicing of the GH1 transcript yields two products: 22K-GH (the principal pituitary GH form) and 20K-GH. Post-translationally modified GH forms include N(alpha)-acylated, deamidated and glycosylated monomeric GH forms, as well as both non-covalent and disulfide-linked oligomers up to at least pentameric GH. GH fragments generated in the course of peripheral metabolis... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532966 Sat, 23 May 2009 23:00:00 +0100 2532966 http://www.medworm.com/index.php?rid=2532968&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19467612%26dopt%3DAbstract Authors: Holt RI, Erotokritou-Mulligan I, Sönksen PH The earliest records of doping in sport come from the Ancient Olympics games when athletes are reported to have taken figs to improve their performance. With the advent of modern pharmacology in the 19th century, many athletes began to experiment with cocktails of drugs to improve strength and overcome fatigue. As this practice was not illegal, there are good records of the lengths athletes would go to in order to win. Alongside the benefits, came the dangers and following several fatalities, a code to ban performance enhancing drugs was gradually developed. Growth hormone was first isolated from the human pituitary gland in the 1950s. Its anabolic effects were soon recognised and athletes had begun to abuse it by the early 1980... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532968 Fri, 22 May 2009 23:00:00 +0100 2532968 http://www.medworm.com/index.php?rid=2532967&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19467613%26dopt%3DAbstract Authors: Holt RI, Bassett EE, Erotokritou-Mulligan I, McHugh C, Cowan D, Bartlett C, Sönksen PH, Growth hormone is abused by athletes for its anabolic and lipolytic properties. The detection of GH abuse is challenging because it is an endogenous hormone whose concentration varies widely in any one day. The GH-2000 project proposed a test based on the measurement of IGF-I and type III pro-collagen (P-III-P). When the results of the GH-2000 project were presented to an expert workshop, the method was supported but it was felt that several issues needed to be resolved before the method could be adopted. The first was a potential effect of ethnicity as most subjects in the GH-2000 were white Europeans and the second was a possible effect of injury as P-III-P is a marker of soft tissu... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532967 Fri, 22 May 2009 23:00:00 +0100 2532967 http://www.medworm.com/index.php?rid=2532965&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19467615%26dopt%3DAbstract Authors: Guha N, Sönksen PH, Holt RI As the tests for detecting growth hormone (GH) abuse develop further, it is likely that athletes will turn to doping with insulin-like growth factor-I (IGF-I). IGF-I mediates many of the anabolic actions of growth hormone. It stimulates muscle protein synthesis, promotes glycogen storage and enhances lipolysis, all of which make IGF-I attractive as a potential performance-enhancing agent. Pharmaceutical companies have developed commercial preparations of recombinant human IGF-I (rhIGF-I) for use in disorders of growth. The increased availability of rhIGF-I increases the opportunity for athletes to acquire supplies of the drug on the black market. The long-term effects of IGF-I administration are currently unknown but it is likely that these wil... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532965 Fri, 22 May 2009 23:00:00 +0100 2532965 http://www.medworm.com/index.php?rid=2532964&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19467616%26dopt%3DAbstract This article gives an overview of the potential application of surface-enhanced laser desorption/ionization time-of-flight (SELDI-TOF) mass spectrometry to examine proteomic changes following GH administration, using both serum and white blood cell extracts as samples for analysis. Results to date indicate that proteomic changes observed following GH administration have the potential to yield novel biomarker sets for the detection of GH abuse. PMID: 19467616 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532964 Fri, 22 May 2009 23:00:00 +0100 2532964 http://www.medworm.com/index.php?rid=2532963&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19467892%26dopt%3DAbstract CONCLUSION: Of the lifestyle factors measured, the most robust relationship observed was a negative association between habitual alcohol intake and all measures of IGF-I. This finding suggests that alcohol intake may blunt the physiologic actions of the IGF-I axis. PMID: 19467892 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532963 Mon, 18 May 2009 23:00:00 +0100 2532963 http://www.medworm.com/index.php?rid=2532969&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19406679%26dopt%3DAbstract CONCLUSIONS: We conclude that early neoplastic lesions (ACFs) were reduced in GH-deficient animals. This effect corresponds with differences in AOM-induced proliferation, but not apoptosis. These data indicate that GH is required for the full effect of AOM on colon ACF and tumor development, and that the SDR rat is a promising model for studies regarding the role ofGH/IGF system in the initiation and promotion of colon cancer. PMID: 19406679 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532969 Mon, 27 Apr 2009 23:00:00 +0100 2532969 http://www.medworm.com/index.php?rid=2532971&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19398211%26dopt%3DAbstract CONCLUSIONS: IGF-I levels were not reduced in patients with CHF and did not influence cardiac status at baseline or the prognosis. PMID: 19398211 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532971 Fri, 24 Apr 2009 23:00:00 +0100 2532971 http://www.medworm.com/index.php?rid=2532972&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19395294%26dopt%3DAbstract In this study, we investigated the effects of maternal high-protein diet or BCAA-supplemented diet upon fetal growth under the condition of maternal calorie restriction. Pregnant mice were calorie-restricted (undernutrition: UN), using either a standard diet (S-UN group), high-protein diet (HP-UN group), or BCAA-supplemented diet (BCAA-UN group) to 70% of the control; dams fed ad libitum with a standard diet (S-NN group) from 10.5days post coitum (dpc) to 18.5dpc. The fetal weights of UN groups were significantly decreased compared to that of S-NN. However, the fetal weights of HP-UN and BCAA-UN were significantly higher by 5% and 4%, respectively, than those of S-UN, concomitant with augmentation of the gene and protein expressions of IGF-I and IGF-II in fetal liver. A high-protein diet a... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532972 Mon, 20 Apr 2009 23:00:00 +0100 2532972 http://www.medworm.com/index.php?rid=2532973&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19386527%26dopt%3DAbstract CONCLUSIONS: Although the molecular mechanisms linking the identified proteins to GH and IGF-1 biological activity remain to be clarified, the results suggest that they represent potential biomarkers of GH and/or IGF-1 action. PMID: 19386527 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532973 Sun, 19 Apr 2009 23:00:00 +0100 2532973 http://www.medworm.com/index.php?rid=2287550&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19303800%26dopt%3DAbstract The objective of the study reported here was the characterization of a candidate standard for IGF-1 in an international collaborative study carried out by 18 laboratories in nine countries, by comparison with (i) a primary calibrant characterized by amino acid analysis and UV spectroscopy, and (ii) the existing International Reference Reagent coded 87/518 by HPLC, immunoassay and bioassay. The study was designed as follows: Phase I involved the establishment of a primary calibrant of rhIGF-1, containing approximately 1.0mg rhIGF-1 per vial. A defined value was assigned to the primary calibrant by amino acid analysis (AAA) and UV spectroscopy. Phase II involved calibration of the candidate standard in terms of the primary calibrant by HPLC, with confirmatory data from immunoassay and bioass... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2287550 Thu, 19 Mar 2009 04:00:00 +0100 2287550 http://www.medworm.com/index.php?rid=2287554&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19303337%26dopt%3DAbstract CONCLUSIONS: A population PK model was established, which showed acceptable performance for trial-simulation purposes. PMID: 19303337 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2287554 Wed, 18 Mar 2009 04:00:00 +0100 2287554 http://www.medworm.com/index.php?rid=2251510&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19269870%26dopt%3DAbstract CONCLUSION: In this transgenic mouse model of acromegaly, there is cardiac and vascular hypertrophy commensurate with GH excess but normal function. Our findings support the contention that the excess mortality in this condition may be due to the development of hypertrophic cardiomyopathy rather than increased rates of atherosclerotic coronary artery disease. PMID: 19269870 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2251510 Fri, 06 Mar 2009 05:00:00 +0100 2251510 http://www.medworm.com/index.php?rid=2222850&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19246225%26dopt%3DAbstract Authors: Pozo ED, Zapf J, Mackenzie AR, Janner M, Perrelet R, Lippuner K, Mullis P Aim of the study was to investigate the possible mechanisms leading to stunted growth and osteoporosis in experimental arthritis. Fourty-two female rats of 7-8weeks of age were randomly assigned to three groups of 14 animals each: (a) controls; (b) adjuvant-inoculated (AA); and (c) adjuvant-inoculated rats receiving 10mg cyclosporin A (CsA) orally for 30days. Biological parameters studied were: hindpaw swelling; vertebral length progression expressed as Delta increments between days 1 and 30 as a parameter of skeletal growth, and estimation of total skeletal mineral content by dual energy X-ray absorptiometry (n=10 each group) on day 30. Endocrine parameters measured were pulsatile release of growth horm... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2222850 Tue, 24 Feb 2009 05:00:00 +0100 2222850 http://www.medworm.com/index.php?rid=2211162&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19231263%26dopt%3DAbstract CONCLUSION: Accelerated nitrogen wasting in the liver and other organs caused by prednisolone treatment was counteracted by treatment with either GH or its secretagogue Ipamorelin, though at the doses given less efficiently by the latter. This functional study of animals confirms that the GH secretagogue exerts GH related metabolic effects and may be useful in the treatment of steroid-induced catabolism. PMID: 19231263 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2211162 Thu, 19 Feb 2009 05:00:00 +0100 2211162 http://www.medworm.com/index.php?rid=2211163&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19230732%26dopt%3DAbstract CONCLUSIONS: Our results suggest that GH leads to increased and reduced levels of anti- and pro-apoptotic proteins, respectively, lowering apoptosis in either young or elder transgenic animals through activation of several kinase pathways. PMID: 19230732 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2211163 Mon, 16 Feb 2009 05:00:00 +0100 2211163 http://www.medworm.com/index.php?rid=2190923&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19217812%26dopt%3DAbstract CONCLUSION: The lower content and reduced phosphorylation of IGF-I signaling observed in adipocytes from SGA children may be related to the metabolic abnormalities described in these children. PMID: 19217812 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2190923 Thu, 12 Feb 2009 05:00:00 +0100 2190923 http://www.medworm.com/index.php?rid=2173265&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19201234%26dopt%3DAbstract In conclusion, long-term chronic exercise improved the metabolic state and attenuated the reduction in serum and hepatic IGF-I concentrations caused by diabetes. PMID: 19201234 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2173265 Thu, 05 Feb 2009 05:00:00 +0100 2173265 http://www.medworm.com/index.php?rid=2167861&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19196529%26dopt%3DAbstract CONCLUSIONS: Anamorelin increases GH, IGF-1, IGFBP-3 and body weight with good tolerability and selectivity, without affecting other anterior pituitary axes or fasting glucose levels. PMID: 19196529 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2167861 Mon, 02 Feb 2009 05:00:00 +0100 2167861 http://www.medworm.com/index.php?rid=2110781&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19144554%26dopt%3DAbstract Authors: Hattori N Immune and neuroendocrine systems have bidirectional communications. Growth hormone (GH) and an orexigenic hormone ghrelin are expressed in various immune cells such as T lymphocytes, B lymphocytes, monocytes and neutrophils. These immune cells also bear receptors for hormones: growth hormone receptor (GHR) for GH and growth hormone secretagogue receptor (GHS-R) for ghrelin. The expression of GH in immune cells is stimulated by ghrelin as in anterior pituitary cells, whereas the regulation of GH secretion in the immune system by other peptides seems to be different from that in the anterior pituitary gland. Cytokines and mitogens enhance GH secretion from immune cells. GH has several biological actions in the immune system: enhancing thymopoiesis and T cell developme... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2110781 Mon, 12 Jan 2009 05:00:00 +0100 2110781 http://www.medworm.com/index.php?rid=2104718&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19138871%26dopt%3DAbstract CONCLUSIONS: In our study, CRP levels are inversely associated with IGF-I concentrations in black male smokers; however, the causal nature of the association is unclear and should be studied further. PMID: 19138871 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2104718 Sat, 10 Jan 2009 05:00:00 +0100 2104718 http://www.medworm.com/index.php?rid=2074766&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19117781%26dopt%3DAbstract CONCLUSION: IGF-I therapy of young patients with Laron syndrome maintain LV dimensions and function within the normal range of aged-matched controls. PMID: 19117781 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2074766 Mon, 29 Dec 2008 05:00:00 +0100 2074766 http://www.medworm.com/index.php?rid=2074767&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19111490%26dopt%3DAbstract CONCLUSIONS: In this study, it was shown that GH-IGF axis was not affected in patients with subclinical hyperthyroidism, while it was affected in patients with subclinical hypothyroidism. That is, investigation of the axis in subclinical hyperthyroidism would not bring any extra advantages, but LT4 replacement therapy could prevent abnormalities related to GH-IGF axis in patients with subclinical hypothyroidism. PMID: 19111490 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2074767 Wed, 24 Dec 2008 05:00:00 +0100 2074767 http://www.medworm.com/index.php?rid=2067842&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19109045%26dopt%3DAbstract CONCLUSION: During pegvisomant treatment, endogenous GH can be reduced significantly by acute application of a somatostatin analogue. Therefore, in acromegalic patients on pegvisomant therapy GH regulation due to somatostatin analogues seems to be preserved. PMID: 19109045 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2067842 Mon, 22 Dec 2008 05:00:00 +0100 2067842 http://www.medworm.com/index.php?rid=2053026&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19091612%26dopt%3DAbstract In this report we offer evidence to show that light treatment (670nm, 80s, intensity 50mW/cm(2), energy density 4J/cm(2)) up-regulates GH release, in part by breakdown of intracellular, oligomeric GH as determined by gel filtration chromatography. PMID: 19091612 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2053026 Mon, 15 Dec 2008 05:00:00 +0100 2053026 http://www.medworm.com/index.php?rid=2047416&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19083250%26dopt%3DAbstract In conclusion, it appears that at rest high circulating levels of GH augment muscle IGF-I protein expression only in the presence of an intact GHR but that the absence of a functional GH receptor does not affect basal levels of muscle IGF-I protein in female mice. PMID: 19083250 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2047416 Tue, 09 Dec 2008 05:00:00 +0100 2047416 http://www.medworm.com/index.php?rid=2027590&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19062321%26dopt%3DAbstract CONCLUSIONS: In Africans a suboptimal nutritional condition may produce a dramatic reduction of IGF-I, ALS and IGFBP-3, although the final height results minimally affected. This suggests that only a small fraction of the circulating IGF-I is sufficient for growth and confirms what has been reported on liver IGF-I-deficient and ALS knock-out mice. The secular statural trend observed in developed countries is probably due to the increase of IGF-I consequent to the improved nutritional conditions. PMID: 19062321 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2027590 Wed, 03 Dec 2008 05:00:00 +0100 2027590 http://www.medworm.com/index.php?rid=2018030&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19056306%26dopt%3DAbstract CONCLUSIONS: Our results suggest that VitD regulation of fetal growth cartilage could have consisted of parallel enhancing of cell differentiation and conditioning to a phenotype more sensitive to regulation by other hormones such as GH as shown by increased GHR and IGF-I expression, but not by IGF-II expression which was not regulated. PMID: 19056306 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2018030 Tue, 02 Dec 2008 05:00:00 +0100 2018030 http://www.medworm.com/index.php?rid=2018029&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19056307%26dopt%3DAbstract CONCLUSION: These results provide a valuable resource for future studies of the structure, dynamics, folding, and binding interactions of IGF-I, as well as analogues thereof, by means of NMR spectroscopy. PMID: 19056307 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2018029 Tue, 02 Dec 2008 05:00:00 +0100 2018029 http://www.medworm.com/index.php?rid=2011409&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19046909%26dopt%3DAbstract In conclusion, although intermittent rhIGF-I therapy elevated serum total IGF-I and prevented any fall in serum IGFBP-3, it failed to increase GFR in non-diabetic patients with advanced CKD. The lack of efficacy was attributed to the presence of renal IGF-I resistance in CKD. PMID: 19046909 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2011409 Thu, 27 Nov 2008 05:00:00 +0100 2011409 http://www.medworm.com/index.php?rid=1996646&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19036620%26dopt%3DAbstract CONCLUSIONS: By adjusting the GH dose, it was feasible to maintain IGF-I in the desired range (0-+2 SDS). Patients carrying at least one GH receptor d3-allele reached higher circulating IGF-I levels than those homozygous for the full-length allele. A multiple regression analysis failed to demonstrate an independent influence of IGF-I levels on GV during the 12 months of observation. PMID: 19036620 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1996646 Mon, 24 Nov 2008 05:00:00 +0100 1996646 http://www.medworm.com/index.php?rid=1969178&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19010705%26dopt%3DAbstract In this study, insulin and IGF-I specificity in terms of gene regulation was investigated in primary human skeletal muscle cells before and after differentiation. Cell cultures were treated with 100nM insulin, IGF-I or nothing for 4h, and gene expression was subsequently determined using the Affymetrix microarray platform. Insulin and IGF-I receptor levels were determined by qRT-PCR and by radioligand binding assays. In primary myoblasts, insulin did not have any significant effect on gene expression, whereas IGF-I regulated 229 genes. In primary myotubes, insulin regulated 105 genes, whereas IGF-I regulated 697 genes. Additionally, 99 genes were found to be differentially regulated by insulin and IGF-I in a direct comparison. The majority of these genes were specifically regulated by IGF-... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1969178 Fri, 14 Nov 2008 05:00:00 +0100 1969178 http://www.medworm.com/index.php?rid=1945404&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18990596%26dopt%3DAbstract CONCLUSION: Our results suggest that the essential branched-chain amino acids in plasma are important for the LBM response to GH substitution. Our finding has to be confirmed in larger groups of GHD adults before making a proper selection of AAs to be measured in plasma and added as dietary supplement during GH therapy. GH administration did not change AA levels and measurements are not useful for monitoring of GH therapy at the time being. PMID: 18990596 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1945404 Wed, 05 Nov 2008 05:00:00 +0100 1945404 http://www.medworm.com/index.php?rid=1934255&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18977675%26dopt%3DAbstract Authors: Nass R, Johansson G, Christiansen JS, Kopchick JJ, Thorner MO The expected increase in the aging population will have a significant impact on society and the health system in the coming years and decades. Enhancing healthspan, "healthy aging", and thus extending the time that the elderly are able to function independently is a significant task and is imperative. Age-dependent changes such as weight loss, sarcopenia and anorexia, which contribute to the development of frailty in the elderly are discussed. The role of the age-dependent decrease in growth hormone secretion in this process and the potential benefits and risks of hormonal interventions to delay, prevent or reverse frailty in the elderly are reviewed. PMID: 18977675 [PubMed - as supplied by publisher] (Source: G... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1934255 Fri, 31 Oct 2008 04:00:00 +0100 1934255 http://www.medworm.com/index.php?rid=1934256&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18976947%26dopt%3DAbstract CONCLUSIONS: GH functions as an autocrine mitogen in adult neurosphere cultures and promotes proliferation of neural progenitor cells as well as self-renewal of neurosphere cultures. In addition, signaling through the GHR appeared to delay neuronal differentiation in adult neurospheres. PMID: 18976947 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1934256 Wed, 29 Oct 2008 04:00:00 +0100 1934256 http://www.medworm.com/index.php?rid=1895399&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18929499%26dopt%3DAbstract CONCLUSION: Polymorphic variation in the IGFBP3 promoter region is correlated with IGFBP-3 levels, spontaneous growth and response to GH treatment in short SGA children. PMID: 18929499 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1895399 Wed, 15 Oct 2008 04:00:00 +0100 1895399 http://www.medworm.com/index.php?rid=1856310&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18835735%26dopt%3DAbstract CONCLUSIONS: Short-term oral oestrogen suppresses IGF-I and elevates GH levels in premenopausal women. No effects were seen on body composition and energy metabolism. Further research is required to determine whether metabolic effects of oral oestrogen may become apparent if longer courses of treatment were administered to premenopausal women. PMID: 18835735 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1856310 Fri, 03 Oct 2008 04:00:00 +0100 1856310 http://www.medworm.com/index.php?rid=1856311&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18835207%26dopt%3DAbstract CONCLUSIONS: We conclude that intermittent exercise is beneficial in preventing a trained lactate pool, and that, in association with glucose supplementation, intermittent exercise will be efficient both in preventing a trained lactate pool and in maintaining sufficient glycemia levels. Exercise raises IGF-1 levels, whereas training inverts this relationship. PMID: 18835207 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1856311 Wed, 01 Oct 2008 04:00:00 +0100 1856311 http://www.medworm.com/index.php?rid=1851143&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18829359%26dopt%3DAbstract CONCLUSION: This analysis provides preliminary data that TBI patients with GHD benefit from hGH replacement in terms of improved QoL in a similar fashion as do NFPA patients. Moreover, it suggests that belated diagnosis and treatment in childhood-onset GHD due to TBI might be related to a shorter final height in these children. PMID: 18829359 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1851143 Tue, 30 Sep 2008 04:00:00 +0100 1851143 http://www.medworm.com/index.php?rid=1841184&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18824380%26dopt%3DAbstract Authors: Ranke MB, Lindberg A The use of growth hormone (GH) to treat children who have disturbances of growth is complicated by variability both within and across diagnostic groups, and at the start of and throughout treatment. Growth prediction models are important tools in the effort to account for these sources of variability and tailor GH treatment to each patient's needs. This review considers the methodological approach taken to the development of models from data in large databases such as the Pfizer International Growth Database (KIGS); it also assesses the limitations of these models and their data sources, and the potential for improvements. While all aspects of model development bear continued scrutiny and improvement, the incorporation of more predictors is key if treatmen... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1841184 Fri, 26 Sep 2008 04:00:00 +0100 1841184 http://www.medworm.com/index.php?rid=1826086&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18809347%26dopt%3DAbstract In conclusion, results of the present data clearly showed: (1) the presence of GHSR-1a in prepubertal pig ovary and found no influence of GH on GHSR-1a protein levels and mRNA expression, and (2) ghrelin effect on estradiol secretion, aromatase activity and cell proliferation dependent of its binding to GHSR-1a, while the effect on cellular apoptosis was independent of its binding to GHSR-1a. PMID: 18809347 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1826086 Sat, 20 Sep 2008 04:00:00 +0100 1826086 http://www.medworm.com/index.php?rid=1826085&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18809348%26dopt%3DAbstract CONCLUSION: These observations indicate that IGF-I reduces stress-induced gastric mucosal injury by inhibiting gastric accumulation of neutrophils through inhibition of caspase-3-mediated EMAP-II activation. Furthermore, IGF-I might inhibit caspase-3 activation through Akt/GSK-3beta signaling. PMID: 18809348 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1826085 Sat, 20 Sep 2008 04:00:00 +0100 1826085 http://www.medworm.com/index.php?rid=1811459&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18801683%26dopt%3DAbstract CONCLUSIONS: Our results indicate that in humans IGF-system components are differentially expressed in the colorectum. Moreover, our findings suggest that local and circulating components of the IGF-system are differentially regulated. However, due to large intra-individual variation in mRNA expression, we cannot formally exclude undetected but existing routes of co-regulation. PMID: 18801683 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1811459 Tue, 16 Sep 2008 04:00:00 +0100 1811459 http://www.medworm.com/index.php?rid=1809906&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18799338%26dopt%3DAbstract CONCLUSION: Although rhGH administration has an effect on liver IGF-I expression, as shown by increase in circulating IGF-I, muscle IGF-I expression is unaffected in young healthy subjects with normal GH profile. The findings contrast with those of a previous study in which GH deficient elderly men showed higher muscle IGF-I 3' splice variant levels following rhGH administration with and without resistance training. Unlike in the liver, muscle Class1 and 2 IGF-I expression do not change significantly following administration of rhGH. PMID: 18799338 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1809906 Mon, 15 Sep 2008 04:00:00 +0100 1809906 http://www.medworm.com/index.php?rid=1802889&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18793862%26dopt%3DAbstract CONCLUSIONS: Higher hPGH levels in AF were found in pregnancies affected by Down's syndrome as compared to normal pregnancies at gestational mid-trimester. hPGH was detected in all AF samples, and it provides evidence that this pregnancy-specific hormone enters the fetal compartment and is not limited to the maternal circulation. The physiological role and effect of hPGH on fetal growth in normal and pathological pregnancies needs further investigation. PMID: 18793862 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1802889 Sat, 13 Sep 2008 04:00:00 +0100 1802889 http://www.medworm.com/index.php?rid=1746766&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18752977%26dopt%3DAbstract CONCLUSION: Low dose GH treatment reduced VAT more markedly in men as compared with women. As all women were postmenopausal and oestrogen-deficient, this gender difference in responsiveness was not due to an antagonistic effect of oestrogen on peripheral GH action. PMID: 18752977 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1746766 Mon, 25 Aug 2008 04:00:00 +0100 1746766 http://www.medworm.com/index.php?rid=1720511&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18710818%26dopt%3DAbstract Authors: Berryman DE, Christiansen JS, Johannsson G, Thorner MO, Kopchick JJ Animal models are fundamentally important in our quest to understand the genetic, epigenetic, and environmental factors that contribute to human aging. In comparison to humans, relatively short-lived mammals are useful models as they allow for rapid assessment of both genetic manipulation and environmental intervention as related to longevity. These models also allow for the study of clinically relevant pathologies as a function of aging. Data associated with more distant species offers additional insight and critical consideration of the basic physiological processes and molecular mechanisms that influence lifespan. Consistently, two interventions, caloric restriction and repression of the growth hormone (GH)... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1720511 Sat, 16 Aug 2008 04:00:00 +0100 1720511 http://www.medworm.com/index.php?rid=1701137&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18693051%26dopt%3DAbstract In conclusion, both IR and IGF-IR are present in human preadipocytes and adipocytes. Differentiation is characterized by an increased IR/IGF-IR ratio. PMID: 18693051 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1701137 Fri, 08 Aug 2008 04:00:00 +0100 1701137 http://www.medworm.com/index.php?rid=1686463&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18678516%26dopt%3DAbstract CONCLUSION:: Hypoglycemia was not seen after glucagon stimulation and decrease in BG occurred above levels physiologically expected to stimulate GH release, being apparently not associated to GH response. PMID: 18678516 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1686463 Sat, 02 Aug 2008 04:00:00 +0100 1686463 http://www.medworm.com/index.php?rid=1668615&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18662893%26dopt%3DAbstract Conclusion: The results support the hypothesis that the IGF-I axis can be programmed early in life. PMID: 18662893 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1668615 Sat, 26 Jul 2008 04:00:00 +0100 1668615 http://www.medworm.com/index.php?rid=1637912&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18632292%26dopt%3DAbstract CONCLUSION: The transcript abundance of the IGF axis in the extra-embryonic membranes and gastrointestinal tissue of the developing chicken, duck, and turkey are influenced by embryonic age and species. A better understanding of the IGF axis in the small intestine during embryonic development may allow for increasing the optimal growth of both the gastrointestinal tract and the neonate. PMID: 18632292 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1637912 Mon, 14 Jul 2008 04:00:00 +0100 1637912 http://www.medworm.com/index.php?rid=1637911&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18632293%26dopt%3DAbstract CONCLUSIONS: Our data demonstrate that localized inflammation induced by intramuscular TO injection is accompanied not only by decreased IGF-I but also by increased IGFBP-1 gene expression explaining at least in part the catabolic changes of metabolism observed during the acute-phase response. PMID: 18632293 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1637911 Mon, 14 Jul 2008 04:00:00 +0100 1637911 http://www.medworm.com/index.php?rid=1616340&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18617430%26dopt%3DAbstract CONCLUSION: While the optimum collection method is immediate centrifugation and storage at -80 degrees C, it would seem acceptable to store serum or clotted blood samples at 4 degrees C, but not ambient temperature, for up to five days. It is incumbent on the anti-doping authorities to provide facilities to allow this. PMID: 18617430 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1616340 Tue, 08 Jul 2008 04:00:00 +0100 1616340 http://www.medworm.com/index.php?rid=1543736&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18567522%26dopt%3DAbstract CONCLUSIONS: Using ERPs recordings, the present study indicates the prolongation of P300 latencies in patients with severe GH deficiency and reduction of P300 amplitudes in patients with acromegaly. This study provides the electrophysiological evidence for the presence of cognitive dysfunction in both GH deficiency and GH excess, and different components of the cognitive performance are impaired in these conditions. PMID: 18567522 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1543736 Fri, 20 Jun 2008 04:00:00 +0100 1543736 http://www.medworm.com/index.php?rid=1543735&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18567523%26dopt%3DAbstract CONCLUSION: Our findings demonstrate the reliability of measurements of hGH in dried blood spots on filter paper. The advantages of this method are the low sample volume and the easy transport, storage, and handling of samples. This method contributes to the standardisation of diagnostics pertaining to abnormal hGH secretion as it facilitates the comparison of decisive measurements. PMID: 18567523 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1543735 Fri, 20 Jun 2008 04:00:00 +0100 1543735 http://www.medworm.com/index.php?rid=1543734&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18571449%26dopt%3DAbstract Authors: Wallis M The insulin-like growth factors (IGF-I and IGF-II) and insulin are related proteins that play an important role in regulation of metabolism and growth. In mammals these proteins are generally strongly conserved, though the sequence of insulin underwent periods of rapid change during the evolution of hystricomorph rodents and new-world monkeys (NWM). The availability of genomic sequence information for a number of mammals provides gene sequences for insulin and IGF precursors from several new species, and this has been used here to study the evolution of these proteins in primates. The sequence of insulin is strongly conserved in primates except for the branch leading to NWM - the sequence of marmoset insulin confirms the episode of rapid evolution in this lineage. Str... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1543734 Wed, 18 Jun 2008 04:00:00 +0100 1543734 http://www.medworm.com/index.php?rid=1518910&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18550406%26dopt%3DAbstract Conclusions: The multivariate reference regions developed in this study should be useful in identifying patients with an abnormal IGF-IGFBP axis. It is suggested that introducing multidimensional reference regions and the described patient indices into clinical practice may aid monitoring of the safety of GH therapy. These patient indices may also be useful in the assessment of cancer risk. PMID: 18550406 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1518910 Tue, 10 Jun 2008 04:00:00 +0100 1518910 http://www.medworm.com/index.php?rid=1518909&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18550407%26dopt%3DAbstract Authors: Yao W, Zhong J, Yu J, Warner T, Bozic T, Ye P, Joseph D'Ercole A, Hock JM, Lee WH Our recent report on a parallel decrease in the body weights and serum IGF-I levels of weaver mice suggests that IGF-I's endocrine function may be impaired in neurodegenerative diseases. To further understand the overall effects of IGF-I deficiency on the postnatal growth, we measured bone mineral density (BMD), bone mineral content (BMC), lean body mass (LBM) and fat mass in male and female weaver mice and wild-type littermates on D21 (prepuberty), D45 (puberty), and D60 (postpuberty) using dual-energy X-ray absorptiometry (DEXA). In both male and female weaver mice, we found that the levels of circulating IGF-I paralleled those of BMD, BMC, and LBM, but not the fat mass. Male weaver mice have n... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1518909 Tue, 10 Jun 2008 04:00:00 +0100 1518909 http://www.medworm.com/index.php?rid=1488545&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18515166%26dopt%3DAbstract CONCLUSIONS: We demonstrated for the first time by real-time quantitative PCR that human fetal epiphyseal chondrocytes expressed IGF axis components, such as IGF-I, IGF-II, IGFBP3, IGF-IR and GHR and SOX9, COL2A1 and aggrecan, and that their expression was regulated by Dx and IGF-I. Among IGFs, IGF-I and not IGF-II expression was demonstrated to be down-regulated by GCs whereas IGF-I expression was up-regulated by itself. PMID: 18515166 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1488545 Fri, 30 May 2008 04:00:00 +0100 1488545 http://www.medworm.com/index.php?rid=1478141&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18508400%26dopt%3DAbstract CONCLUSION: IGFBP subfamily divergence is associated with variable domain insertion or deletion and vigorous non-synonymous codon mutation. Our findings suggest strong selective pressure for IGFBP divergence in terrestrial vertebrates. PMID: 18508400 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1478141 Mon, 26 May 2008 04:00:00 +0100 1478141 http://www.medworm.com/index.php?rid=1469972&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18502671%26dopt%3DAbstract CONCLUSIONS: Daytime sleepiness is increased in a homogeneous cohort of patients in long-term remission from acromegaly. In addition, somatostatin analog treatment increases sleep latency and delays sleep onset in patients with long-term biochemical control of growth hormone overproduction without altering total sleep duration. PMID: 18502671 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1469972 Fri, 23 May 2008 04:00:00 +0100 1469972 http://www.medworm.com/index.php?rid=1469973&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18502161%26dopt%3DAbstract CONCLUSIONS: Our novel findings provide evidence for in vivo activity of rhIGFBP-3 against lung and colon tumor models and reveal new insight into its interaction with chemotherapeutic drugs. The antitumor effects of rhIGFBP-3 are associated with a downregulation of AKT signaling. PMID: 18502161 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1469973 Thu, 22 May 2008 04:00:00 +0100 1469973 http://www.medworm.com/index.php?rid=1466222&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18499495%26dopt%3DAbstract CONCLUSION: In conclusion, the genetic manipulation of GH expression (bGH) and its receptor binding (GHR-/-) had profound and divergent effects on muscle phenotype. It is hoped that continued research in this area will help elucidate the direct (independent of IGF-1) vs. indirect (via IGF-1 mediating mechanisms) effects of GH. PMID: 18499495 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1466222 Tue, 20 May 2008 04:00:00 +0100 1466222 http://www.medworm.com/index.php?rid=1449487&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18482854%26dopt%3DAbstract CONCLUSION: Although bioGH was not associated with BMD, IGF-I and associated binding proteins (IGFBP-3 and ALS) emerged as correlates in W only. PMID: 18482854 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1449487 Tue, 13 May 2008 04:00:00 +0100 1449487 http://www.medworm.com/index.php?rid=1432701&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18462969%26dopt%3DAbstract CONCLUSION: NAFLD is a frequent complication in untreated and treated congenital IGF-I deficiency. No correlation between NAFLD and age, sex, degree of obesity, blood lipids, or degree of insulin resistance was observed. PMID: 18462969 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1432701 Mon, 05 May 2008 04:00:00 +0100 1432701 http://www.medworm.com/index.php?rid=1407283&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18440847%26dopt%3DAbstract CONCLUSIONS: Our results provide experimental evidence that the atypical IGF-I receptor variant expressed in subclone inducible C2.7 is issued from a post-translational processing of mouse IGF-I receptor. We show that this post-translational modification is closely associated with the cell lines indeed permissive C2.7 myoblasts process mouse cDNA IGF-I receptor as a classical IGF-I receptor whereas inducible C2.7 myoblasts process mouse cDNA IGF-I receptor as an atypical IGF-I receptor. On other hand, we show that overexpression of mouse IGF-I receptor in inducible myoblasts does not abrogate IGF-I or IGF-II requirement to differentiate. PMID: 18440847 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1407283 Fri, 25 Apr 2008 04:00:00 +0100 1407283 http://www.medworm.com/index.php?rid=1391232&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18424208%26dopt%3DAbstract CONCLUSIONS: The present study confirms the role of the IGF and EGF system in proliferation and differentiation of skeletal muscle cell culture especially under serum-free culture conditions. Furthermore, the results of this in vitro-study suggest that there is no effect of isoflavones at concentrations resulting from dietary consumption (1 and 10muM) on IGF- and EGF-associated gene expression in porcine skeletal muscle tissue. Genistein and daidzein at high concentration (100muM) reduced the mRNA expression of the IGF-I receptor and the growth factors examined, and therefore, may modify their autocrine and paracrine actions in skeletal muscle tissue. PMID: 18424208 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1391232 Wed, 16 Apr 2008 04:00:00 +0100 1391232 http://www.medworm.com/index.php?rid=1361057&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18395480%26dopt%3DAbstract CONCLUSIONS: Treatment with GH was associated with a significant reduction in trunk fat and improvement in serum lipid profile in Japanese adult GH-deficient patients. The improvement in body composition and tolerability were comparable between ID and FD GH regimens despite a significantly lower daily GH dose with the ID regimen. PMID: 18395480 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1361057 Thu, 03 Apr 2008 04:00:00 +0100 1361057 http://www.medworm.com/index.php?rid=1347521&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18381245%26dopt%3DAbstract CONCLUSIONS: Our study demonstrates both systemic and local disturbances of the IGF-system in rats with type-2 diabetes, consistent with the observed enhanced endosteal erosion in long bone diaphyses, and osteopenia in metaphyses and vertebrae. Whether similar IGF-system changes contribute to osteopathy in patients with diabetes and if treatment of diabetes can reverse the osteopathy has yet to be explored. PMID: 18381245 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1347521 Sun, 30 Mar 2008 04:00:00 +0100 1347521 http://www.medworm.com/index.php?rid=1344520&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18378173%26dopt%3DAbstract CONCLUSION: Children with JIA and mild degree of growth retardation show decreased ALS and IGFBP-3. Cytokines did not show an association to systemic markers of GH secretion. However, this study reports the novel, preliminary association between serum levels of IL5 and IL15 and the extent of short stature. PMID: 18378173 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1344520 Fri, 28 Mar 2008 04:00:00 +0100 1344520 http://www.medworm.com/index.php?rid=1316767&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18348909%26dopt%3DAbstract Conclusion: We observed a prevalence of discordance similar to that previously described in the literature. We believe that studies evaluating morbidity and mortality in discordant patients are also necessary and will enlighten the true impact of this condition in the follow up of acromegaly. PMID: 18348909 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1316767 Sun, 16 Mar 2008 04:00:00 +0100 1316767 http://www.medworm.com/index.php?rid=1297897&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18331806%26dopt%3DAbstract CONCLUSIONS: This study shows for the first time the profile of growth plate gene expression modifications caused by GH treatment in experimental uremia and provides a basis to further investigate selected individual genes with potential implication in the stimulating effect on the growth of GH treatment in chronic renal failure. PMID: 18331806 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1297897 Sat, 08 Mar 2008 05:00:00 +0100 1297897 http://www.medworm.com/index.php?rid=1294650&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18329307%26dopt%3DAbstract Authors: Nogami H, Hisano S Recent studies have disclosed the molecular mechanisms responsible for the phenotype determination of the anterior pituitary cell types. However, as far as growth hormone (GH) cells are concerned, particular extra-cellular cues are required for the initiation of GH and GH-releasing hormone (GHRH)-receptor gene production in addition to the expression of the cell type specific transcription factor, pit-1. The glucocorticoids play a principal role in the functional maturation of nascent GH cells in the fetal pituitary glands in rodents, inducing GH and GHRH-receptor gene expression, and establish the GH secretory system regulated by the brain in late gestation. Research supporting this role for glucocorticoid in the development of GH cells is discussed. PM... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1294650 Thu, 06 Mar 2008 05:00:00 +0100 1294650 http://www.medworm.com/index.php?rid=1294649&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18329308%26dopt%3DAbstract CONCLUSIONS: Reference values of IGF-I for African boys and girls were determined. They will be used for endocrine evaluations and nutritional monitoring. PMID: 18329308 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1294649 Thu, 06 Mar 2008 05:00:00 +0100 1294649 http://www.medworm.com/index.php?rid=1294651&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18328759%26dopt%3DAbstract CONCLUSIONS: Our findings demonstrate that the plasmin can differentially modulate platelet aggregation in response to intrinsic heterogeneities within the IGF axis. PMID: 18328759 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1294651 Wed, 05 Mar 2008 05:00:00 +0100 1294651 http://www.medworm.com/index.php?rid=1286379&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18321745%26dopt%3DAbstract Authors: Harada N, Okajima K, Narimatsu N, Kurihara H, Nakagata N Sensory neurons release calcitonin gene-related peptide (CGRP) on activation. We recently reported that topical application of capsaicin increases facial skin elasticity and promotes hair growth by increasing dermal insulin-like growth factor-I (IGF-I) production through activation of sensory neurons in mice and humans. Raspberry ketone (RK), a major aromatic compound contained in red raspberries (Rubus idaeus), has a structure similar to that of capsaicin. Thus, it is possible that RK activates sensory neurons, thereby increasing skin elasticity and promoting hair growth by increasing dermal IGF-I production. In the present study, we examined this possibility in mice and humans. RK, at concentrations higher than 1muM, s... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1286379 Mon, 03 Mar 2008 05:00:00 +0100 1286379 http://www.medworm.com/index.php?rid=1270669&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18308605%26dopt%3DAbstract Authors: Hoeflich A Transgenic animal technology has tremendously improved our current comprehension of IGFBP biology. The high potential of IGFBP transgenic mouse models is due to the fact that they mimic elevated serum IGFBP levels, which are diagnosed under the conditions of impaired growth or critical illness. In general, long term elevated levels of IGFBPs in transgenic mouse models almost exclusively resulted in inhibitory phenotypes e.g. of body or organ growth, indicating specific effects in different cell types. This holds especially for the distinct cellular populations present in the bone environment. After establishing transgenic mouse lines modelling permanent increases of IGFBPs, a second question now poses challenge to current functional genome analysis: what is the func... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1270669 Tue, 26 Feb 2008 05:00:00 +0100 1270669 http://www.medworm.com/index.php?rid=1268543&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18304850%26dopt%3DAbstract The objective of present study was to investigate the effect of CLA on insulin resistance and its molecular mechanisms. Fifty male Wistar rats were randomly designed to the control, high-fat and high-fat with CLA (0.75, 1.50, and 3.00g in per 100g diet) groups. The effect of CLA on insulin sensitivity and the mechanism of resisting diabetes by CLA were investigated by RT-PCR assay. The results showed that supplementation with CLA significantly reduced body weight gain and white fat pad weight in the rats, the levels of plasma free fatty acids (FFA), triglycerides (TGs), cholesterin (TC), leptin, insulin and blood glucose concentration in the obese rats of CLA group were also decreased compared to the rats in the high-fat group. Dietary CLA increased the mRNA expression of PPARgamma, fatty ... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1268543 Mon, 25 Feb 2008 05:00:00 +0100 1268543 http://www.medworm.com/index.php?rid=1250319&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18289903%26dopt%3DAbstract CONCLUSIONS: Our 4-year study in GH deficient adults showed significant beneficial effects on some cardiovascular risk parameters and BMC in treated patients. However, there are still unsettled issues regarding long-term benefits and these patients should be carefully monitored. PMID: 18289903 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1250319 Mon, 18 Feb 2008 05:00:00 +0100 1250319 http://www.medworm.com/index.php?rid=1245235&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18282776%26dopt%3DAbstract CONCLUSION: Long-term GH replacement therapy was well tolerated in Japanese adults with GHD. GH treatment maintained the improvements in body composition and lipid profiles in the patients previously treated in the double-blind study (GH-GH group) and improved these parameters in previously untreated patients (Placebo-GH group). Individualised GH administration based on IGF-I levels was well-tolerated and effective. PMID: 18282776 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1245235 Fri, 15 Feb 2008 05:00:00 +0100 1245235 http://www.medworm.com/index.php?rid=1231958&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18269934%26dopt%3DAbstract CONCLUSIONS: The data establishes the importance of IGF-activated PI3-K in rescuing cells from apoptosis. It lends further evidence to the significance of IGF proteins in the possible development of oral cancer. PMID: 18269934 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1231958 Mon, 11 Feb 2008 05:00:00 +0100 1231958 http://www.medworm.com/index.php?rid=1152743&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18191600%26dopt%3DAbstract In conclusion, GH effects were dose-dependent and both tested doses did not aggravate the heart dysfunction. The higher GH dose, 2mg/kg exerted detrimental effects related to energy metabolism and oxidative stress. The lower dose, 1mg/kg GH exerted beneficial effects enhancing antioxidant defences, reducing oxidative stress and improving energy generation in myocardium of rats with heart failure. PMID: 18191600 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1152743 Wed, 09 Jan 2008 05:00:00 +0100 1152743 http://www.medworm.com/index.php?rid=1142560&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18182313%26dopt%3DAbstract Authors: Wit JM, Clayton PE, Rogol AD, Savage MO, Saenger PH, Cohen P Idiopathic short stature is a condition in which the height of the individual is more than 2 SD below the corresponding mean height for a given age, sex and population, in whom no identifiable disorder is present. It can be subcategorized into familial and non-familial ISS, and according to pubertal delay. It should be differentiated from dysmorphic syndromes, skeletal dysplasias, short stature secondary to a small birth size (small for gestational age, SGA), and systemic and endocrine diseases. ISS is the diagnostic group that remains after excluding known conditions in short children. PMID: 18182313 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1142560 Sat, 05 Jan 2008 05:00:00 +0100 1142560 http://www.medworm.com/index.php?rid=1137101&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18178497%26dopt%3DAbstract CONCLUSIONS: Our present data show a concurrence of elevated GH levels and decreased IGF-I, IGFBP-3, and total ghrelin levels during the early burn injury period, in addition to more GH burst amplitude as well as greater falling of IGF-I, IGFBP-3 and total ghrelin levels proportional to the severity of burn injury. Further studies are needed to ascertain whether acyl- and desacyl-ghrelin instead of total ghrelin are completely independent of increased GH or other stress mediators, and whether GH-releasing hormone (GHRH) mainly stimulates the production and release of GH in acute critical conditions. PMID: 18178497 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1137101 Fri, 04 Jan 2008 05:00:00 +0100 1137101 http://www.medworm.com/index.php?rid=1137100&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18178498%26dopt%3DAbstract Authors: Wit JM, Reiter EO, Ross JL, Saenger PH, Savage MO, Rogol AD, Cohen P In the management of ISS auxological, biochemical, psychosocial and ethical elements have to be considered. In boys with constitutional delay of growth and puberty androgens are effective in increasing height and sexual characteristics, but adult height is unchanged. GH therapy is efficacious in increasing height velocity and adult height, but the inter-individual variation is considerable. The effect on psychosocial status is uncertain. Factors affecting final height gain include GH dose, height deficit in comparison to midparental height, age and first year height velocity. In case of a low predicted adult height at the onset of puberty, addition of a GnRH analogue can be considered. Although GH therapy app... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1137100 Fri, 04 Jan 2008 05:00:00 +0100 1137100 http://www.medworm.com/index.php?rid=1126375&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18166495%26dopt%3DAbstract CONCLUSIONS: GH administration selectively augments the early-outgrowth EPC population in healthy individuals. These findings both support GH replacement in the setting of GH deficiency to maintain vascular integrity and have implications for the use of GH in future regenerative cell-based therapies. Furthermore, the decrease in EPCs observed with aging may in part be explained by the declining somatotropic axis, and thereby contribute to cardiovascular senescence. PMID: 18166495 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1126375 Sat, 29 Dec 2007 05:00:00 +0100 1126375 http://www.medworm.com/index.php?rid=1076768&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18054508%26dopt%3DAbstract CONCLUSIONS: It is, therefore, unlikely that a post-prandial variation in levels of small, dense LDL may significantly contribute to the atherogenic potential in hypopituitary patients with GHD. PMID: 18054508 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1076768 Sat, 01 Dec 2007 05:00:00 +0100 1076768 http://www.medworm.com/index.php?rid=1052511&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18037316%26dopt%3DAbstract Authors: Kraemer WJ, Nindl BC, Volek JS, Marx JO, Gotshalk LA, Bush JA, Welsch JR, Vingren JL, Spiering BA, Fragala MS, Hatfield DL, Ho JY, Maresh CM, Mastro AM, Hymer WC The purpose was to examine effects of oral contraceptive (OC) use on plasma growth hormone (GH) responses to heavy resistance exercise. Sixty untrained women were placed into one of two groups: currently using OC (Ortho Tri-Cyclen((R))) (n=25; mean+/-SD: 24.5+/-4.2y, 160.4+/-7.1cm, 64.1+/-11.3kg) or not currently using OC (NOC) (n=35; 23.6+/-4.6y, 165.9+/-6.0cm, 65.7+/-10.3kg). Participants performed an acute heavy resistance exercise test (AHRET; six sets of 10 repetition squats; 2min rest between sets) during days 2-4 of the follicular phase (NOC group) or of inactive oral contraceptive intake (OC group). Plasma was... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1052511 Wed, 21 Nov 2007 05:00:00 +0100 1052511 http://www.medworm.com/index.php?rid=1041784&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18023601%26dopt%3DAbstract CONCLUSION: GH did not affect cellular immune functions or the survival rate in our murine sepsis model. In contrast, IGF-I improved splenocyte proliferation and cytokine release independently of GH but did not affect the determined clinical parameters of septic mice. PMID: 18023601 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1041784 Sat, 17 Nov 2007 05:00:00 +0100 1041784 http://www.medworm.com/index.php?rid=1022446&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17997337%26dopt%3DAbstract CONCLUSION: The present study established age- and sex-specific reference ranges for serum IGF-1 and IGFBP-3 levels. Quantile regression should be preferred to calculate reference ranges because a better concordance to original data is possible due to no distribution assumption are required and the robustness against outliers is given. PMID: 17997337 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=1022446 Tue, 06 Nov 2007 05:00:00 +0100 1022446 http://www.medworm.com/index.php?rid=980640&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17959403%26dopt%3DAbstract CONCLUSIONS: The N-terminal 1-97-IGFBP-3 fragment induces apoptosis in human prostate cancer cells in an IGF-independent manner. Generation of the fragment might contribute to the proapoptotic activity of IGFBP-3 in vivo. PMID: 17959403 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=980640 Mon, 22 Oct 2007 04:00:00 +0100 980640 http://www.medworm.com/index.php?rid=974603&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17951088%26dopt%3DAbstract In conclusion, our study provides novel evidence for the gonadal feedback loop between GH and ghrelin secretion in the ovary. However, results of the presented research suggest independent action of GH and ghrelin in the ovary. PMID: 17951088 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=974603 Fri, 19 Oct 2007 04:00:00 +0100 974603 http://www.medworm.com/index.php?rid=965307&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17945524%26dopt%3DAbstract CONCLUSIONS: When IGF-I is characterized with respect to the effect on living cells and on binding to potential receptors unspecific binding to surfaces is often prevented by the addition of albumin in the assay. Here we report that when binding to the classical IGF-IR and IR/IGF-IR hybrid receptors are studied the measured EC50 values can be albumin dependent if it is contaminated with proteins with IGF-I binding properties. The free IGF-I concentration will be lower than estimated. Thus, the contaminated BSA preparations result in artifacts leading to misinterpretations and underestimation of the effect of IGF-I. Our results provide one possible explanation as to why different laboratories report different EC50 values for IGF-I. PMID: 17945524 [PubMed - as supplied by publisher] (Sou... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=965307 Tue, 16 Oct 2007 04:00:00 +0100 965307