MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Growth Hormone and IGF Research' source. Wed, 08 Feb 2012 15:08:58 +0100 http://www.medworm.com/index.php?rid=5643184&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22269954%26dopt%3DAbstract In this study only 21% (4/19) of the patients who received fractionated radiotherapy for a non-endocrine brain tumor were diagnosed with GHD. GHD in these patients was associated with impaired interference control, attentional shifting, and visual long-term memory. The results for interference control and attentional shifting suggest an additional effect of the radiation history. PMID: 22269954 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=5643184 Sat, 21 Jan 2012 05:00:00 +0100 5643184 http://www.medworm.com/index.php?rid=5625874&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22257554%26dopt%3DAbstract CONCLUSIONS: PEG-rhGH had the same linear growth promoting efficacy as unmodified rhGH. The short-term GH replacement could improve insulin sensitivity in hypophysectomized rats, especially after PEGylation. PMID: 22257554 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=5625874 Mon, 16 Jan 2012 05:00:00 +0100 5625874 http://www.medworm.com/index.php?rid=5625875&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22245162%26dopt%3DAbstract CONCLUSION: The bench step exercise leads to improvements in not only the classical risk factors of atherosclerosis but also the arterial stiffness in elderly women, partly through NO production via IGF-1 bioactivity. PMID: 22245162 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=5625875 Thu, 12 Jan 2012 05:00:00 +0100 5625875 http://www.medworm.com/index.php?rid=5625876&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22244673%26dopt%3DAbstract CONCLUSIONS: Short-term rhGH and rhIGF-I administration was found to increase muscle IGFBP-5 mRNA, whereas only rhIGF-I administration decreased muscle IGFBP-3 mRNA in control and arthritic rats. These data suggest that arthritis does not induce GH or IGF-I resistance in skeletal muscle. PMID: 22244673 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=5625876 Wed, 11 Jan 2012 05:00:00 +0100 5625876 http://www.medworm.com/index.php?rid=5579983&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22226996%26dopt%3DAbstract CONCLUSIONS: We observed protein S deficiency more frequent than seen in the general population and normalization of protein S activity and decreases, in other natural anticoagulants following GHRT. Further studies are required to understand the impact of these changes in cardiovascular morbidity and mortality in this patient population. PMID: 22226996 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=5579983 Thu, 05 Jan 2012 05:00:00 +0100 5579983 http://www.medworm.com/index.php?rid=5552203&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22197584%26dopt%3DAbstract CONCLUSIONS: These data indicate that, unlike the muscle, heart and skin, elevated levels of IGF-1Ea in the proximal tubules exacerbates ischemia reperfusion injury resulting in increased recruitment of macrophages and neutrophils and delays repair in a renal setting. PMID: 22197584 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=5552203 Fri, 23 Dec 2011 05:00:00 +0100 5552203 http://www.medworm.com/index.php?rid=5515317&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22154520%26dopt%3DAbstract CONCLUSION: The inverse association between IGF-I serum concentrations and QTc interval in our study is suggestive of a higher risk for cardiac arrhythmias and thus might provide additional evidence for increased cardiovascular mortality in subjects with low IGF-I secretion. PMID: 22154520 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=5515317 Fri, 09 Dec 2011 05:00:00 +0100 5515317 http://www.medworm.com/index.php?rid=5382701&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22015109%26dopt%3DAbstract Authors: Muthusami S, Ramachandran I, Krishnamoorthy S, Govindan R, Narasimhan S Abstract Osteoporosis is a public health problem which is associated with significant morbidity and mortality. Growth factors are produced locally in the bone and control cellular events such as induction of bone growth. Signaling through the Insulin-like growth factor (IGF)-I receptor (IGF-IR) by locally synthesized IGF - I or IGF-II in osteoblast is considered crucial for normal development and for bone remodeling. Traditional use of Cissus quadrangularis (C. quadrangularis) in the treatment of bone disorders have been documented, however its regulatory effects on IGF system components remain largely unknown. The present study is employed to delineate the effects of ethanolic extract of C. quadrangul... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=5382701 Mon, 07 Nov 2011 21:50:20 +0100 5382701 http://www.medworm.com/index.php?rid=5382700&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22019012%26dopt%3DAbstract Authors: Kappelgaard AM, Laursen T Abstract This review will summarize the effects of growth hormone (GH) on height, body composition, bone and psychosocial parameters in children with Turner syndrome or Noonan syndrome and those born small for gestational age. The safety of GH treatment in children with these diagnoses is also reported. Despite the reported efficacy and safety of GH in these indications, however, not all children achieve their target height potential, due in some part to poor adherence to GH therapy regimens; indeed up to 50% of children are less than fully compliant with treatment. With this in mind the present and future administration of GH therapy is discussed with respect to advances being made in the presentation of GH for injection and advances in GH inject... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=5382700 Mon, 07 Nov 2011 21:50:11 +0100 5382700 http://www.medworm.com/index.php?rid=5331989&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22001433%26dopt%3DAbstract CONCLUSIONS: Altogether our results demonstrated that the -667 G/A and the -396 C/T polymorphisms in IGFBP3 promoter region influence the basal transcriptional activity of the gene. PMID: 22001433 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=5331989 Fri, 14 Oct 2011 04:00:00 +0100 5331989 http://www.medworm.com/index.php?rid=5331990&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21975122%26dopt%3DAbstract CONCLUSION: The IGFGT is a suitable method for measuring reproducible and biologically conclusive transcriptional changes in PBMC. As our unsupervised data analysis strategy exposed a considerable inter-individual variability of response profiles a search for molecules of diagnostic and even prognostic value needs to be based on large long-term studies. PMID: 21975122 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=5331990 Mon, 03 Oct 2011 04:00:00 +0100 5331990 http://www.medworm.com/index.php?rid=5331991&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21967820%26dopt%3DAbstract CONCLUSION: This study suggests that IGF-I may be beneficial to semen stored for longer periods of time. Adding 150ng/mL IGF-I improved the quality of semen stored for 24h, and adding 78ng/mL IGF-I improved the quality of semen stored for 72h. PMID: 21967820 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=5331991 Sat, 01 Oct 2011 04:00:00 +0100 5331991 http://www.medworm.com/index.php?rid=5283246&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21963127%26dopt%3DAbstract CONCLUSION: IGF-I, CTX and OST are suitable candidate markers of prolonged, illicit administration of GH. Furthermore, CTX and OST have potentials to serve as markers also after cessation of GH administration. PMID: 21963127 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=5283246 Thu, 29 Sep 2011 04:00:00 +0100 5283246 http://www.medworm.com/index.php?rid=5266583&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21944866%26dopt%3DAbstract CONCLUSION: Polymorphic variation in the GH-1, IGF-1 and IGFBP-3 genes is associated with extremely tall stature. In particular, the IGFBP-3 -202 SNP is associated not only with being very tall but also with height variation within the tall. PMID: 21944866 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=5266583 Thu, 22 Sep 2011 04:00:00 +0100 5266583 http://www.medworm.com/index.php?rid=5221183&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21903439%26dopt%3DAbstract CONCLUSIONS: Children with isolated GHD have normal GH secretory capacity during the first week of life while the majority of children with MPHD and pituitary malformation were GH deficient immediately after birth. PMID: 21903439 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=5221183 Tue, 06 Sep 2011 04:00:00 +0100 5221183 http://www.medworm.com/index.php?rid=5160148&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21862442%26dopt%3DAbstract CONCLUSION: While a severe deficiency of circulating IGF-I impairs body growth, UNx induces a significant and proportional increase in renal mass in ID mice despite markedly decreased kidney IGF-I levels (>90% reduction) and no significant change in receptor phosphorylation. This all suggests that factors other than circulating and locally produced IGF-I are responsible for compensatory renal enlargement. PMID: 21862442 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=5160148 Sun, 21 Aug 2011 23:00:00 +0100 5160148 http://www.medworm.com/index.php?rid=5160147&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21865066%26dopt%3DAbstract CONCLUSIONS: This study established normative reference values for the QoL-AGHDA in a representative sample of the German population. Based on these normative data a QoL-AGHDA cut-off value for prediction of improvement was investigated for the German population, which may facilitate clinical assessment of HRQoL response to GH replacement for patients with GHD. PMID: 21865066 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=5160147 Sun, 21 Aug 2011 23:00:00 +0100 5160147 http://www.medworm.com/index.php?rid=5160146&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21865067%26dopt%3DAbstract CONCLUSIONS: IGF1R inhibition by PQ401 exerted no significant effects on diabetic kidney disease parameters, arguing against a role for IGF-I in the pathogenesis of diabetic kidney disease. However, PQ401 affects normal kidneys, inducing renal hypertrophy as well as collagen and fat accumulation, with increased renal IGF-I mRNA, suggestive of a damage-regeneration process. Therefore, this diarylurea compound is not beneficial in early diabetic kidney disease. Its potential deleterious effects on kidney tissue need to be further investigated. PMID: 21865067 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=5160146 Sun, 21 Aug 2011 23:00:00 +0100 5160146 http://www.medworm.com/index.php?rid=5160145&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21865068%26dopt%3DAbstract CONCLUSIONS: Our data generate the therapeutic potential for PEG-IGF-I to treat CNS disorders by systemic drug application, and in addition scientifically support its application in disorders of synaptic function and neuronal development. PMID: 21865068 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=5160145 Sun, 21 Aug 2011 23:00:00 +0100 5160145 http://www.medworm.com/index.php?rid=5142506&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21839661%26dopt%3DAbstract We examined whether DHT inhibits IGF-I production by inhibiting sensory neuron stimulation, thereby preventing hair growth in mice. Effect of DHT on sensory neuron stimulation was examined using cultured dorsal root ganglion (DRG) neurons isolated from mice. DHT inhibits calcitonin gene-related peptide (CGRP) release from cultured DRG neurons. The non-steroidal androgen-receptor antagonist flutamide reversed DHT-induced inhibition of CGRP release. Dermal levels of IGF-I and IGF-I mRNA, and the number of IGF-I-positive fibroblasts around hair follicles were increased at 6h after CGRP administration. DHT administration for 3weeks decreased dermal levels of CGRP, IGF-I, and IGF-I mRNA in mice. Immunohistochemical expression of IGF-I and the number of proliferating cells in hair follicles were... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=5142506 Tue, 09 Aug 2011 23:00:00 +0100 5142506 http://www.medworm.com/index.php?rid=5142505&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21839662%26dopt%3DAbstract CONCLUSIONS: Present cross-sectional study for the first time showed a negative association of serum IGF-I with serum adiponectin in Japanese men with type 2 diabetes independent of age, duration of diabetes, BMI, renal function, and HbA1c. PMID: 21839662 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=5142505 Tue, 09 Aug 2011 23:00:00 +0100 5142505 http://www.medworm.com/index.php?rid=5108373&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21820924%26dopt%3DAbstract CONCLUSIONS: The present study provides the first evidence that GHR exon 3 polymorphism is associated with PCOS in Han Chinese women. The GHRd3 allele may contribute to an impact of glucose metabolism but not insulin resistance. PMID: 21820924 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=5108373 Wed, 03 Aug 2011 23:00:00 +0100 5108373 http://www.medworm.com/index.php?rid=5108374&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21820343%26dopt%3DAbstract CONCLUSION: Our observations indicate that the stimulating effect of NHS is completely dependent on IGF-I receptor signaling transduction and that IGF-I stimulates DNA synthesis in prostate cancer cells in strong synergy with other serum factors. We speculate that the role of other serum factors could explain the discrepancy between the results observed in different animal models to study the function of IGF-I in prostate cancer. PMID: 21820343 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=5108374 Tue, 02 Aug 2011 23:00:00 +0100 5108374 http://www.medworm.com/index.php?rid=5108375&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21802327%26dopt%3DAbstract CONCLUSIONS: An increase in IGF-II expression did not rescue the skeletal and reproductive deficiencies associated with reduced local IGF-I signaling in PAPP-A KO mice. In addition, the data suggest a potential new role for genomic imprinting at the IgfII/H19 locus affecting maternal behavior. PMID: 21802327 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=5108375 Tue, 26 Jul 2011 23:00:00 +0100 5108375 http://www.medworm.com/index.php?rid=5012061&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21705251%26dopt%3DAbstract CONCLUSIONS: Mice expressing bGH display a selective inner retinal defect as demonstrated using ERG recordings. The specific OP defect observed in these mice is similar to the ERG results obtained in patients with diabetic retinopathy and in related animal models. PMID: 21705251 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=5012061 Thu, 23 Jun 2011 23:00:00 +0100 5012061 http://www.medworm.com/index.php?rid=5012062&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21703892%26dopt%3DAbstract CONCLUSIONS: Expression of relatively abundant amounts of both IGF-1 splicing isoforms in EOMs, and at a significantly higher level than in limb skeletal muscle, underscores the potential relevance of these myogenic growth factors in EOM plasticity and force regulation. PMID: 21703892 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=5012062 Tue, 21 Jun 2011 23:00:00 +0100 5012062 http://www.medworm.com/index.php?rid=4969076&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21696987%26dopt%3DAbstract CONCLUSIONS: Prolonged administration of rhIGF-I/rhIGFBP-3 did not have a negative impact on blood glucose levels and was beneficial for total body growth. PMID: 21696987 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4969076 Sun, 19 Jun 2011 23:00:00 +0100 4969076 http://www.medworm.com/index.php?rid=4969077&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21665508%26dopt%3DAbstract CONCLUSIONS: Here we provide a new rational approach which allows the substitution of arbitrarily defined GH cut-offs by those based on auxology. PMID: 21665508 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4969077 Thu, 09 Jun 2011 23:00:00 +0100 4969077 http://www.medworm.com/index.php?rid=4969079&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21664161%26dopt%3DAbstract CONCLUSION: The known beneficial effects of GH treatment upon body composition in PWS are maintained during two years continuous treatment. With appropriate control, GH is a safe treatment option in adults with PWS. PMID: 21664161 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4969079 Tue, 07 Jun 2011 23:00:00 +0100 4969079 http://www.medworm.com/index.php?rid=4969078&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21664162%26dopt%3DAbstract Growth Horm IGF Res. 2011 Jun 8; Authors: Rensing KL, van Duyvenvoorde HA, Cramer MJ, Teske AJ, Prokop M, Stroes ES, Wit JM, Hermus AR, Twickler TB PMID: 21664162 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4969078 Tue, 07 Jun 2011 23:00:00 +0100 4969078 http://www.medworm.com/index.php?rid=4922310&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21641842%26dopt%3DAbstract We present three cases of remitting Cushing's disease complicated with growth hormone deficiency. Surprisingly, growth hormone replacement resulted in complete clinical and laboratory remission of Cushing's disease in these patients. However, one of the patients died of myocardial infarction. Effects of growth hormone on cortisol metabolism are discussed. PMID: 21641842 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4922310 Thu, 02 Jun 2011 23:00:00 +0100 4922310 http://www.medworm.com/index.php?rid=4922309&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21658592%26dopt%3DAbstract Authors: Vindeløv SD, Hartoft-Nielsen ML, Rasmussen AK, Bendtzen K, Kosteljanetz M, Andersson AM, Feldt-Rasmussen U Pituitary adenomas cause morbidity and mortality due to their localization and influence on pituitary hormone secretion. Although the pathogenesis of pituitary adenomas is unclear, studies have indicated that cytokines are involved. We investigated the role of cytokines, in particular interleukin (IL)-8, in the pathogenesis of growth hormone (GH) producing tumours. PMID: 21658592 [PubMed - in process] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4922309 Tue, 31 May 2011 23:00:00 +0100 4922309 http://www.medworm.com/index.php?rid=4922308&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21658593%26dopt%3DAbstract CONCLUSION: Homozygosity for the 192bp allele of the IGF-I gene polymorphism suggests a healthier aging condition, with less prevalence of cardiometabolic disturbances, and better mental, nutritional and functional state. PMID: 21658593 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4922308 Tue, 31 May 2011 23:00:00 +0100 4922308 http://www.medworm.com/index.php?rid=4922307&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21658594%26dopt%3DAbstract We present an additional case of a suprasellar choriocarcinoma producing GH, and review the literature. PMID: 21658594 [PubMed - in process] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4922307 Tue, 31 May 2011 23:00:00 +0100 4922307 http://www.medworm.com/index.php?rid=4922311&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21636299%26dopt%3DAbstract CONCLUSIONS: Our data provide evidence that the components of the trimeric IGF-I-IGFBP-3-ALS complex are altered in CAH children with possible implications on pubertal growth and final height. PMID: 21636299 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4922311 Mon, 30 May 2011 23:00:00 +0100 4922311 http://www.medworm.com/index.php?rid=4922312&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21624842%26dopt%3DAbstract CONCLUSION: Breastfeeding has a strong negative effect on IGF-I concentrations in late infancy. Although IGF-I concentrations at 9months of age were negatively associated with change in BMI during the following 9months we speculate that this could reflect an early adiposity rebound and thereby an increased risk of obesity later in life. PMID: 21624842 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4922312 Fri, 27 May 2011 23:00:00 +0100 4922312 http://www.medworm.com/index.php?rid=4823461&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21550830%26dopt%3DAbstract CONCLUSIONS: Our results indicate that the neutrophil-derived preparation of azurocidin contains a protease activity which cleaves IGFBP-1, IGFBP-2 and IGFBP-4. These findings are of interest since both IGFBP-1 and azurocidin increase during inflammation. The effect of azurocidin on IGFBP- and IGF-activity needs to be further investigated. PMID: 21550830 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4823461 Thu, 05 May 2011 23:00:00 +0100 4823461 http://www.medworm.com/index.php?rid=4823462&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21546299%26dopt%3DAbstract CONCLUSIONS: The clinical data of the patient combined with the laboratory data support the diagnosis of partial IGHD type II. Since the GH deficiency was not total, additional binding and signaling studies were performed, which revealed that the GH-P59L variant displays some of the common features of bioinactive GH syndrome. Taken together, in this study we report a patient suffering from the combination of two growth disorders (alteration of secretion as well as bioactivity) caused by a GH-1 gene alteration highlighting the necessity of functional analysis of any GH variant, despite the presence of obvious clinical features of IGHD type II. PMID: 21546299 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4823462 Mon, 02 May 2011 23:00:00 +0100 4823462 http://www.medworm.com/index.php?rid=4823463&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21536469%26dopt%3DAbstract Authors: Safarinejad MR, Shafiei N, Safarinejad S The bioavailability of IGF-I is controlled by the binding protein, IGF binding protein-3 (IGFBP-3). In addition, IGFBP-3 is a strong anti-proliferative protein that provokes apoptosis and inhibits cell proliferation in prostate cancer. We conducted this study to investigate the association between IGFBP-3 gene polymorphism and serum levels of IGF-I and IGFBP-3 and the incidence of prostate cancer (PCa) and benign prostatic hyperplasia (BPH). DNA isolation was performed in peripheral blood samples obtained from all participants. Required areas were amplified with polymerase chain reaction restriction fragment length polymorphism (PCR-RLFP) technique by using proper primers belonging to this gene area. We also measured serum IGF-I and IGF... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4823463 Fri, 29 Apr 2011 23:00:00 +0100 4823463 http://www.medworm.com/index.php?rid=4823464&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21531600%26dopt%3DAbstract CONCLUSIONS: Our study demonstrates a strong relationship between specific parameters of endogenous GH pulsatility and adiponectin. However, short-term augmentation of GH pulsatility over 2-weeks does not change adiponectin. Therefore, the relationship between GH and adiponectin is most likely mediated by specific covariates related to adiposity or other factors. PMID: 21531600 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4823464 Thu, 28 Apr 2011 23:00:00 +0100 4823464 http://www.medworm.com/index.php?rid=4823466&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21498099%26dopt%3DAbstract Authors: Neggers SJ, van der Lely AJ Mono-therapy using long-acting somatostatin analogues and surgery cannot provide optimal biochemical control in a large proportion of patients with acromegaly. This results in increased mortality, poor control of signs and symptoms of disease and decreased quality of life. Combined treatment with somatostatin analogues and pegvisomant (a growth-hormone-receptor antagonist) seems to be an attractive option. Combination treatment is highly effective at normalising the level of insulin-like growth factor 1 in over 90% of patients and has a favourable effect on quality of life in those with biochemically controlled acromegaly. Moreover, combination therapy with somatostatin analogues results in a clinically relevant decrease in tumour size in about 20% ... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4823466 Thu, 14 Apr 2011 23:00:00 +0100 4823466 http://www.medworm.com/index.php?rid=4823465&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21498100%26dopt%3DAbstract CONCLUSION: GH receptor blocker administration in healthy humans resulted in a moderate decrease in serum IGF-I. Collagen synthesis in tendon and skeletal muscle, as well as skeletal muscle IGF-I and collagen mRNA expression, was unaffected by GH receptor blocker supplementation. PMID: 21498100 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4823465 Thu, 14 Apr 2011 23:00:00 +0100 4823465 http://www.medworm.com/index.php?rid=4823467&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21470887%26dopt%3DAbstract Authors: Berryman DE, List EO, Sackmann-Sala L, Lubbers E, Munn R, Kopchick JJ The last two decades have seen resurgence in research focused on adipose tissue. In part, the enhanced interest stems from an alarming increase in obesity rates worldwide. However, an understanding that this once simple tissue is significantly more intricate and interactive than previously realized has fostered additional attention. While few would argue that growth hormone (GH) radically alters fat mass, newer findings revealing the complexity of adipose tissue requires that GH's influence on this tissue be reexamined. Therefore, the objective of this review is to describe the more recent understanding of adipose tissue and to summarize our current knowledge of how GH may influence and contribute to these n... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4823467 Sun, 03 Apr 2011 23:00:00 +0100 4823467 http://www.medworm.com/index.php?rid=4823469&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21459028%26dopt%3DAbstract In conclusion, IGF1 promotes development to the blastocyst stage by regulating MAPK-dependent events at Day 4 or later of development. PMID: 21459028 [PubMed - in process] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4823469 Thu, 31 Mar 2011 23:00:00 +0100 4823469 http://www.medworm.com/index.php?rid=4823468&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21459641%26dopt%3DAbstract CONCLUSION: IGF-I is positively associated with aerobic fitness and muscular endurance, but not with measures of muscle strength or FFM. IGF-I is positively associated with improved health and fitness outcomes in young, healthy men. PMID: 21459641 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4823468 Thu, 31 Mar 2011 23:00:00 +0100 4823468 http://www.medworm.com/index.php?rid=4663537&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21450501%26dopt%3DAbstract CONCLUSION: GHD adults have elevated VEGF levels, which correlate with MMP9 levels. Both VEGF and MMP9 are associated with vascular pathologies and may provide insight in to the pathophysiological mechanisms underlying the increased vascular morbidity and mortality observed in GHD adults. PMID: 21450501 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4663537 Sun, 27 Mar 2011 23:00:00 +0100 4663537 http://www.medworm.com/index.php?rid=4663539&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21435927%26dopt%3DAbstract CONCLUSIONS: The present study revealed a U-shaped relation between IGF-I and all-cause mortality in male primary care patients. PMID: 21435927 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4663539 Tue, 22 Mar 2011 00:00:00 +0100 4663539 http://www.medworm.com/index.php?rid=4604279&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21393039%26dopt%3DAbstract CONCLUSIONS: Low IGF-I and IGFBP-3 independently predict future health care costs and hospitalization. IGF-I or IGFBP-3 might be useful to identify subjects with excess health care use. The predictive performance of cross-sectional and longitudinal models of total and inpatient costs were slightly improved by adding IGF-I or IGFBP-3 but the cost-effectiveness of inclusion into prediction models needs to be examined. PMID: 21393039 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4604279 Tue, 08 Mar 2011 00:00:00 +0100 4604279 http://www.medworm.com/index.php?rid=4604280&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21371927%26dopt%3DAbstract DISCUSSION: Our data indicate that GHD during adolescence leads to overt diastolic dysfunction in early adulthood and this is prevented by continual GH replacement therapy. Since discontinuation of GH replacement following adolescence only mitigated the lusitropic deficits that were observed in untreated dwarfs, GH treatment into adulthood could be beneficial. PMID: 21371927 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4604280 Tue, 01 Mar 2011 00:00:00 +0100 4604280 http://www.medworm.com/index.php?rid=4483975&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21295507%26dopt%3DAbstract CONCLUSION: Long-term replacement of growth hormone in patients with AOGHD induces favorable effects on QoL as well as bone and metabolic parameters. An increase in insulin levels is also noteworthy. PMID: 21295507 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4483975 Wed, 02 Feb 2011 00:00:00 +0100 4483975 http://www.medworm.com/index.php?rid=4483976&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21277816%26dopt%3DAbstract CONCLUSIONS: These findings show that GHD reduces aggressive behavior in GHRHKO mice, that GH replacement normalizes aggressiveness, and that this behavior change is not related to an increase in serum testosterone. PMID: 21277816 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4483976 Fri, 28 Jan 2011 00:00:00 +0100 4483976 http://www.medworm.com/index.php?rid=4416193&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21251861%26dopt%3DAbstract CONCLUSIONS: Despite improvements in physical performance, a 48-week training program did not affect any of the circulating IGF system measurements. Disparities between these findings and those of other researchers reporting a biphasic response to long-term training may be explained by differences in study groups and exercise programs. PMID: 21251861 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4416193 Tue, 18 Jan 2011 00:00:00 +0100 4416193 http://www.medworm.com/index.php?rid=4416194&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21239198%26dopt%3DAbstract CONCLUSION: The present study has shown that aging is associated with significant alterations in the relative expression of pancreatic genes involved in insulin secretion as well as in the differentiation and in the intra islet glucose metabolism. According to our results, GH administration to old SAMP8 mice was able to improve the pancreatic function of the old SAMP8 mice and to decrease insulin and glucagon expressions in the pancreas improving instead insulin levels and glucose metabolism. PMID: 21239198 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4416194 Fri, 14 Jan 2011 00:00:00 +0100 4416194 http://www.medworm.com/index.php?rid=4416196&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21237681%26dopt%3DAbstract CONCLUSIONS: The data presented herein extend the body of evidence on the potential role of HMβ-treatment in stimulating GH/IGF-I axis activity. In spite of this effect, HMβ supplementation also induces an apparent insulin resistance state which might limit the beneficial aspects of the former results, at least in rats under normal nutritional status and health conditions. PMID: 21237681 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4416196 Thu, 13 Jan 2011 00:00:00 +0100 4416196 http://www.medworm.com/index.php?rid=4416195&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21237682%26dopt%3DAbstract CONCLUSIONS: There is no evidence that the severe short stature associated with heterozygosity for this novel IGF1 mutation in children born from a mother with the same mutation is caused by a dominant negative effect of the truncated protein. We speculate that the growth failure is caused by a combination of partial IGF-I deficiency, placental IGF-I insufficiency, and other genetic factors. PMID: 21237682 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4416195 Thu, 13 Jan 2011 00:00:00 +0100 4416195 http://www.medworm.com/index.php?rid=4355181&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21232999%26dopt%3DAbstract CONCLUSIONS: In individuals with a GH gene deletion, rhIGF-I promotes increased height velocity, but may be associated with adverse effects on lipids and BMI. It is clear that the long-term effects of rhIGF-I on lipid metabolism and body composition require further monitoring and assessment with continued treatment. PMID: 21232999 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4355181 Tue, 11 Jan 2011 00:00:00 +0100 4355181 http://www.medworm.com/index.php?rid=4355184&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21212010%26dopt%3DAbstract CONCLUSIONS: Pregnancy-induced increase in IGF-I levels is associated with progression of diabetic retinopathy in women with type 1 diabetes. PMID: 21212010 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4355184 Tue, 04 Jan 2011 00:00:00 +0100 4355184 http://www.medworm.com/index.php?rid=4355183&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21212011%26dopt%3DAbstract Authors: Walser M, Hansén A, Svensson PA, Jernås M, Oscarsson J, Isgaard J, Aberg ND Growth hormone (GH) therapy substantially improves several cognitive functions in hypopituitary experimental animals and in humans. Although a number of biochemical correlates to these effects have been characterized, there are no comprehensive analysis available examining effects of GH on the brain. Hypophysectomized female rats were given replacement therapy with cortisol and thyroxine (=hx). Subcutaneous infusions of bovine GH (bGH, henceforth designated GH) were supplied in osmotic minipumps for 6days (=hx+GH). To evaluate whether GH normalized specific transcript expression levels in cerebral cortex, pituitary-intact rats were used as normal controls. DNA microarrays (Affymetrix) of cerebrocorti... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4355183 Tue, 04 Jan 2011 00:00:00 +0100 4355183 http://www.medworm.com/index.php?rid=4355182&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21212012%26dopt%3DAbstract CONCLUSION: Decreased placental expression levels of hPGH, IGF-I and IGFBP-1 were demonstrated in pregnancies with FGR. Whether these alterations are a causative factor of FGR or accompany other pathogenetic mechanisms requires further investigation. PMID: 21212012 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4355182 Tue, 04 Jan 2011 00:00:00 +0100 4355182 http://www.medworm.com/index.php?rid=4285471&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21177131%26dopt%3DAbstract Authors: Nogami H, Lee MC, Soya H, Hisano S Expression of the first exon variants of the rat growth hormone receptor mRNA was studied in the brain and the pituitary gland. Four of the five different variant mRNA previously identified in the liver were detected in the cerebral cortex by a conventional reverse-transcription polymerase chain reaction, and, unlike the data reported previously, a quantitative analysis revealed that approximately 90% of the total growth hormone receptor mRNA in the cerebral cortex is V1 form. The present results suggest that the V1 was also a dominant transcript in other brain areas and the pituitary gland, not only in adult but also in fetal and postnatal period. The growth hormone receptor expression in the brain was lower during fetal period than in adult... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4285471 Mon, 20 Dec 2010 00:00:00 +0100 4285471 http://www.medworm.com/index.php?rid=4205579&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21093334%26dopt%3DAbstract CONCLUSION: These observational data show long-term beneficial effects of GH replacement therapy on QoL and show no significant effects on total cholesterol, LDL-C or BMI, WC and HC. Additionally, our data indicate that GH replacement therapy in adults is well tolerated. PMID: 21093334 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4205579 Thu, 18 Nov 2010 00:00:00 +0100 4205579 http://www.medworm.com/index.php?rid=4173007&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21075030%26dopt%3DAbstract CONCLUSION: Both OC use and GSTT1 and GSTM1 genotypes may influence IGF-1 levels. Further studies are warranted to confirm our finding and elucidate the clinical importance. PMID: 21075030 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4173007 Thu, 11 Nov 2010 00:00:00 +0100 4173007 http://www.medworm.com/index.php?rid=4173008&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21071248%26dopt%3DAbstract CONCLUSION: The fat and skin necroses represent a side-effect not previously described after deep subcutaneous injections. Possibly, the patient had an exceptional susceptibility to develop an inflammatory, foreign-body like reaction that hypothetically was aggravated by a sustained anti-angiogenic effect of the compound. PMID: 21071248 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4173008 Tue, 09 Nov 2010 00:00:00 +0100 4173008 http://www.medworm.com/index.php?rid=4158450&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21055982%26dopt%3DAbstract CONCLUSIONS: Insulin glargine was more potent in activating the IGF-IR than HI and insulin detemir. Since KIRA bioassays do not mimic the exact in vivo situation, further research is needed to find out whether our data have implications for clinical use of insulin glargine. PMID: 21055982 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4158450 Wed, 03 Nov 2010 00:00:00 +0100 4158450 http://www.medworm.com/index.php?rid=4140851&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21051252%26dopt%3DAbstract CONCLUSION: Type 2 diabetes patients with chronic kidney disease requiring hemodialysis (CKD5D) have a high mean basal level of IGFBP-1 in spite of increased insulin levels. The first 90min response of IGFBP-1 to insulin infusion is similar in T2D patients with CKD5D and T1D patients with normal renal function. After 90min of insulin infusion a blunted decrease in IGFBP-1 was seen in T2D patients with CKD5D compared with type \1 diabetes with normal renal function. Insulin infusion before hemodialysis reduced the earlier reported increase in IGFBP-1 and increased IGF-I levels. Insulin infusion before dialysis in patients with CKD5D should be further studied since it could contribute to an anabolic effect with more bioavaialable IGF-I thus reducing the catabolic effect of hemodialysis. ... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4140851 Tue, 02 Nov 2010 00:00:00 +0100 4140851 http://www.medworm.com/index.php?rid=4098798&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20956084%26dopt%3DAbstract Authors: Li Y, Geng YJ Recent success in reprogramming somatic cells into induced pluripotent stem cells (iPS cells) with a cluster of nuclear transcription factors, such as Oct4, Sox2, Klf4, and c-myc, opens up a new era in regenerative medicine. However, reportedly poor efficiency and slow kinetics of the reprogramming process by viral transfection of the nuclear factors may create an obstacle that hampers clinical application of the iPS cell technology. Furthermore, the viral transfection may induce mutagenesis and raises the risk for cancer development. Hence, generation of iPS cells using a non-viral approach appears to be an important prerequisite for iPS cell-based regenerative medicine. Through its receptor/phosphoinositide 3-kinase (PI3-K) signaling pathway, insulin-like growt... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4098798 Fri, 15 Oct 2010 23:00:00 +0100 4098798 http://www.medworm.com/index.php?rid=4066904&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20940102%26dopt%3DAbstract CONCLUSIONS: A significant blunting of GH responsiveness ensues after a second bout of different GH-releasing stimuli, independent from the amount of GH released after the first bout. This is a pattern also observed for other pharmacological stimuli and exercise modalities, and suggests a common mechanism underlying different GH-releasing stimuli. PMID: 20940102 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4066904 Sun, 10 Oct 2010 23:00:00 +0100 4066904 http://www.medworm.com/index.php?rid=4030892&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20889360%26dopt%3DAbstract CONCLUSION: Serum IGF-I concentrations are associated with peak exercise capacity in healthy women, but not in men over a wide range in ages, body sizes and activity scores. PMID: 20889360 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=4030892 Fri, 01 Oct 2010 23:00:00 +0100 4030892 http://www.medworm.com/index.php?rid=3958790&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20801067%26dopt%3DAbstract CONCLUSIONS: The present study suggests that HIT/acidosis is a stimulus for exercise-induced cortisol/hGH secretion, but not for IGF-1 and IGFBP-3 under these experimental conditions. These findings might be relevant for arrangements of interval training, due to the fact that active or passive recovery during rest periods influence the acid base status and may therefore influence the hormonal response. PMID: 20801067 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3958790 Wed, 25 Aug 2010 23:00:00 +0100 3958790 http://www.medworm.com/index.php?rid=3903886&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20724185%26dopt%3DAbstract CONCLUSION: Year-long postmenopausal HRT was found to affect the expression of the genes along the IGF-1 signaling cascade reflecting the higher muscle mass compared to the CO women. By using cell culture model we were, however, unable to confirm the possible differential role of E(2) and NETA. It appears that the synchronous presence of both effective agents of the HRT or the presence of yet unidentified microenvironmental factors providing proper paracrine signals naturally existing in the intact muscle tissue is critical for appropriate signaling via sex steroid-IGF-1 axis to occur. PMID: 20724185 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3903886 Mon, 16 Aug 2010 23:00:00 +0100 3903886 http://www.medworm.com/index.php?rid=3875986&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20708421%26dopt%3DAbstract This study incorporated injection technique training, a defined injection site, and a larger sample size to accommodate variability. It also included a third formulation, creating a 3-period crossover design to assess the BE of 2.5, 5, and 10mg/mL. Study B results demonstrated BE of the new 2.5- and 10-mg/mL formulations to the reference 5-mg/mL formulation, and BE to each other, with all 90% CIs within the BE range of 0.80 to 1.25. Thus the challenge of recognizing that design issues could affect outcomes gave us the tools to perform a second study, and the positive results taught us that demonstrating BE is an issue not only of pharmacology, but also of study methodology and execution. PMID: 20708421 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3875986 Tue, 10 Aug 2010 23:00:00 +0100 3875986 http://www.medworm.com/index.php?rid=3813906&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20675162%26dopt%3DAbstract CONCLUSION: His-tags are commonly added to proteins during synthesis to allow a convenient and complete purification of the final product and His-tags are subsequently removed by specific enzymes when being attached to the N-terminus. The effects of His-tagged Long-R(3)-IGF-I in humans have not been elucidated or described and the product may rather be a by-product from biochemical studies than synthesized for injection purposes. PMID: 20675162 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3813906 Thu, 29 Jul 2010 23:00:00 +0100 3813906 http://www.medworm.com/index.php?rid=3813907&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20673733%26dopt%3DAbstract Authors: Anderson D, Baker M, Grignol G, Hu W, Merchenthaler I, Dudas B Previous studies revealed that growth hormone-releasing hormone (GHRH)-immunoreactive (IR) neurons form a circumscribed cell group in the basal infundibulum/median eminence of the human hypothalamus. GHRH from these neurons is released into the hypothalamo-hypophyseal portal circulatory system in a pulsatile manner. It is a common consensus that the pulsatile release of GHRH is the main driving force behind the pulsatile release of growth hormone (GH) and may contribute to the regulation of other hypothalamic functions. The pulsatile release of GHRH requires synchronized activity of GHRH-IR neurons. However, the morphological basis of this synchronization between the GHRH-IR neural elements has not been elucidated ... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3813907 Wed, 28 Jul 2010 23:00:00 +0100 3813907 http://www.medworm.com/index.php?rid=3798872&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20656537%26dopt%3DAbstract CONCLUSIONS: Vesiculin, des(37-40)IGF-II, is a novel two-chain insulin-like hormone and the major "IGF-II-like" peptide found in purified mouse betaTC6-F7 secretory granules. It stimulated ex vivo muscle glycogen synthesis with an efficacy greater than or equal to the intrinsic potency of IGF-II when compared to insulin derived from the same species. PMID: 20656537 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3798872 Thu, 22 Jul 2010 23:00:00 +0100 3798872 http://www.medworm.com/index.php?rid=3798873&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20655258%26dopt%3DAbstract CONCLUSIONS: A number of genes were identified as being differentially expressed in the bGH kidney. Inclusion of two groups, immunoglobulins and inflammation-related genes, suggests a role of the immune system in bGH kidney damage. PMID: 20655258 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3798873 Wed, 21 Jul 2010 23:00:00 +0100 3798873 http://www.medworm.com/index.php?rid=3727360&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20598930%26dopt%3DAbstract CONCLUSIONS: Patients who develop GHD following cure of acromegaly do not demonstrate elevated LV mass, in contrast to patients with a history of acromegaly but normal GH levels or to patients with active acromegaly. This suggests that GH status after treatment of acromegaly correlates with LV mass, and that, in GH sufficient patients, reversal of remodeling may be slower than previously thought. These data suggest that it will be important to determine whether GH replacement alters left ventricular morphology over time. PMID: 20598930 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3727360 Wed, 30 Jun 2010 23:00:00 +0100 3727360 http://www.medworm.com/index.php?rid=3727361&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20598600%26dopt%3DAbstract CONCLUSION: Endogenous GH is not significantly decreased after a single oral cabergoline application during pegvisomant treatment in acromegaly. PMID: 20598600 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3727361 Tue, 29 Jun 2010 23:00:00 +0100 3727361 http://www.medworm.com/index.php?rid=3703255&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20576456%26dopt%3DAbstract CONCLUSION: An early increase in SRA mRNA and protein expression in the bGH kidney precedes glomerular scarring and is independent of macrophage influx. PMID: 20576456 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3703255 Tue, 22 Jun 2010 23:00:00 +0100 3703255 http://www.medworm.com/index.php?rid=3603978&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20494600%26dopt%3DAbstract Authors: Dai Z, Wu F, Yeung EW, Li Y Insulin-like growth factor I (IGF-I) is an important growth factor for embryonic development, postnatal growth, tissue repair and maintenance of homeostasis. IGF-I functions and regulations are complex and tissue-specific. IGF-I mediates growth hormone signaling to target tissues during growth, but many IGF-I variants have been discovered, resulting in complex models to describe IGF-I function and regulation. Mechano-growth factor (MGF) is an alternative splicing variant of IGF-I and serves as a local tissue repair factor that responds to changes in physiological conditions or environmental stimuli. MGF expression is significantly increased in muscle, bone and tendon following damage resulting from mechanical stimuli and in the brain and heart follo... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3603978 Wed, 19 May 2010 23:00:00 +0100 3603978 http://www.medworm.com/index.php?rid=3586495&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20483644%26dopt%3DAbstract This study addressed the hypothesis that chronic Ang II infusion suppresses hepatic growth hormone receptor (GHr) and IGF1 expressions via an Ang II receptor (AT1)-mediated pathway associated with elevated glucocorticoids. Sprague-Dawley rats were assigned to three groups: 1) Control, 2) Ang II-infused (80ng/min x 28d) and 3) Ang II+angiotensin receptor blocker (ARB; 10mg losartan/kg/dx21d). After 28d, Ang II decreased body mass by 14% (407+/-8 vs 350+/-17g) and hepatic AT1a, GHr, and IGF1 mRNA expressions by 45%, 44%, and 44%, respectively. ARB treatment completely prevented the loss in body mass (409+/-9g) and AT1a and GHr expressions and partially recovered the loss of hepatic IGF1. Ang II increased plasma corticosterone (B) 3-fold (173+/-28 vs 555+/-42ng/mL) and ARB treatment prevented... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3586495 Sun, 16 May 2010 23:00:00 +0100 3586495 http://www.medworm.com/index.php?rid=3586494&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20483645%26dopt%3DAbstract CONCLUSIONS: Some studies have shown H19, and IGF2 genes (or related genes or protein, for example, IGF2R and IMP-3) differential expression in melanoma. However, no study has attempted to examine markers across this cluster in relation to melanoma until now. Since the base change may impair the pairing of microRNA and its binding site, our results suggest a new window for future studies of IGF2 and H19 genetic variability and posttranscriptional regulation. Due to the importance and based on the present results, we suggest that the genotype/haplotype analysis of IGF2 and H19 polymorphisms should be better investigated in large populations with cutaneous melanoma, attempting to tie the association with progression of the disease. PMID: 20483645 [PubMed - as supplied by publisher] (Sour... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3586494 Sun, 16 May 2010 23:00:00 +0100 3586494 http://www.medworm.com/index.php?rid=3574156&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20472479%26dopt%3DAbstract CONCLUSIONS: The topological arrangement of monomeric hGHs to form an unusually stable disulfide-linked dimer markedly diminishes hGH's binding affinities to both GH and PRL receptors and also drastically attenuates its ability to stimulate proliferation of cells in vitro. PMID: 20472479 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3574156 Thu, 13 May 2010 23:00:00 +0100 3574156 http://www.medworm.com/index.php?rid=3574155&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20472480%26dopt%3DAbstract In conclusion, sprint exercise suppresses total ghrelin concentrations and stimulates GH release but does not alter IGF concentrations or bioactivity. PMID: 20472480 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3574155 Thu, 13 May 2010 23:00:00 +0100 3574155 http://www.medworm.com/index.php?rid=3460726&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20382057%26dopt%3DAbstract Authors: Temmerman L, Slonimsky E, Rosenthal N Insulin-like growth factor 1 (IGF-1) is a pleiotropic factor involved in growth, cell survival and cellular differentiation. It exerts its functions through endocrine, paracrine or autocrine mechanisms. Circulating IGF-1 is essential for normal fetal and postnatal growth, although the published phenotypes of IGF-1 null animals have been only partially penetrant, presumably due to mixed genetic backgrounds. Molecular dissection of IGF-1 action is complicated by the existence of at least nine different IGF-1 isoforms, generated in both humans and rodents by usage of alternate promoters, differential splicing and different post-translational modifications. Several lines of evidence suggest that the Class 2 IGF-1 isoform is specifically destin... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3460726 Wed, 07 Apr 2010 23:00:00 +0100 3460726 http://www.medworm.com/index.php?rid=3421392&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20347606%26dopt%3DAbstract CONCLUSIONS: We conclude that IGF1R and IGF2R differential expression may contribute to the increased risk of malignant transformation in young AA women and to the more aggressive breast cancer phenotype observed among AA breast cancer patients and represent, along with IGF-II, potential therapeutic targets in breast cancer. PMID: 20347606 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3421392 Fri, 26 Mar 2010 00:00:00 +0100 3421392 http://www.medworm.com/index.php?rid=3395590&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20304691%26dopt%3DAbstract CONCLUSIONS: Specific monoclonal antibodies and ultrasensitive chemiluminescent immunoassays for 20K and 22K hGH were generated. The ultrasensitive immunoassays are essential for the determination of 20K and 22K hGH in the basal GH state. This universal ultrasensitive immunoassay form can be adapted to other immunoassays for broad application. PMID: 20304691 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3395590 Fri, 19 Mar 2010 00:00:00 +0100 3395590 http://www.medworm.com/index.php?rid=3358188&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20219400%26dopt%3DAbstract CONCLUSION: In summary, our study did not observe any influence of IGFBP-3 promoter methylation on protein expression. Moreover we propose that IGFBP-3 immunostaining in gastric tissue may be a useful marker for malignancy. PMID: 20219400 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3358188 Mon, 08 Mar 2010 00:00:00 +0100 3358188 http://www.medworm.com/index.php?rid=3358187&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20219401%26dopt%3DAbstract CONCLUSION: The GHR d3/fl polymorphism can be studied by TaqMan SNP genotyping. Use of the tagSNP facilitates investigations of the effects of the d3/fl polymorphism in large cohorts. PMID: 20219401 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3358187 Mon, 08 Mar 2010 00:00:00 +0100 3358187 http://www.medworm.com/index.php?rid=3338808&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20199883%26dopt%3DAbstract CONCLUSIONS: Body fat was primarily located subcutaneously and metabolic consequences of obesity limited. The abnormal body composition similar to that in non-PWS GHD adults increases the interest of GH treatment in the prevention of obesity in adults with PWS. PMID: 20199883 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3338808 Tue, 02 Mar 2010 00:00:00 +0100 3338808 http://www.medworm.com/index.php?rid=3332049&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20194043%26dopt%3DAbstract CONCLUSION: These findings accentuate the importance of recognition of the clinical manifestations of arthropathy in patients with acromegaly despite long-term disease control. PMID: 20194043 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3332049 Sat, 27 Feb 2010 00:00:00 +0100 3332049 http://www.medworm.com/index.php?rid=3312740&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20185347%26dopt%3DAbstract CONCLUSIONS: Physiological GHR for at least 6months in hypopituitary adults with recently diagnosed severe GHD resulted in favourable changes in hs-CRP, WHR, fasting LDL-C and HDL-C levels all of which are recognised CV risk markers. However, there remains a high prevalence of obesity in this population and given the worsening of insulin sensitivity in the short term with GHR, monitoring and aggressive treatment of established CV risk factors is essential to reduce premature atherosclerotic CVD in this patient population. PMID: 20185347 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3312740 Tue, 23 Feb 2010 00:00:00 +0100 3312740 http://www.medworm.com/index.php?rid=3312739&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20185348%26dopt%3DAbstract CONCLUSIONS: These data indicate that IGF-I inhibited insulin activity in the 3T3-L1 adipocytes via ROS production, which affects IRS-1 phosphorylation status. PMID: 20185348 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3312739 Tue, 23 Feb 2010 00:00:00 +0100 3312739 http://www.medworm.com/index.php?rid=3306436&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20176498%26dopt%3DAbstract CONCLUSIONS: GH treatment significantly improved serum levels of IGF-I and body composition in a dose-responsive manner in Japanese AGHD patients. Total cholesterol and LDL-cholesterol levels also decreased. GH treatment was safe and generally well tolerated. PMID: 20176498 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3306436 Sat, 20 Feb 2010 00:00:00 +0100 3306436 http://www.medworm.com/index.php?rid=3270336&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20149700%26dopt%3DAbstract CONCLUSIONS: In addition to an association with catch-up growth, GHR exon 3 genotype significantly modulates HbA1c and IGFBP-1 concentrations in former ELBW infants. In order to confirm this observation and to clarify whether the GHRd3-variant might be considered as an independent modulator of the low birth weight infant's risk to develop insulin resistance later in life, larger studies extending to later ages are required. PMID: 20149700 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3270336 Mon, 08 Feb 2010 00:00:00 +0100 3270336 http://www.medworm.com/index.php?rid=3264473&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20144555%26dopt%3DAbstract Authors: Phang D, Rehage M, Bonafede B, Hou D, Xing W, Mohan S, Wergedal JE, Qin X In vivo studies have provided ubiquitous evidence that pregnancy-associated plasma protein-A (PAPP-A) functions as a potent anabolic factor. While some evidence supports the prediction that increasing IGF bioavailability contributes to the anabolic effects of PAPP-A, definitive evidence has been lacking. This important issue has been addressed in this study using a unique mouse model in which PAPP-A was overexpressed in bone either alone or together with a protease-resistant IGFBP-4 analog (PRBP-4) which serves as an IGF inhibitor. PAPP-A transgenic mice exhibited a 25% increase in skull bone mineral density (BMD) whereas PRBP-4 transgenic mice showed a 20-25% decrease in this parameter at an age of 3mon... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3264473 Sat, 06 Feb 2010 00:00:00 +0100 3264473 http://www.medworm.com/index.php?rid=3221445&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20110184%26dopt%3DAbstract CONCLUSION: Serum IGF-II/M6P-R is up-regulated in morbid obesity, down-regulated by weight loss and elevated in moderately obese T2D. However, although plasma IGF-II was also reduced following GB, the two peptides were not statistically correlated. No acute effect of insulin was seen. These findings indicate that the IGF-II/M6P-R is nutritionally regulated, independently of IGF-II. PMID: 20110184 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3221445 Tue, 26 Jan 2010 00:00:00 +0100 3221445 http://www.medworm.com/index.php?rid=3221446&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20106687%26dopt%3DAbstract Authors: David Åberg N, Lind J, Isgaard J, Georg Kuhn H Growth hormone (GH) and insulin-like growth factor I (IGF-I) increase cell genesis in several regions of the brains of GH-IGF-I-deficient hypophysectomized rats. However, it is not known to what degree GH treatment stimulates adult cell genesis in pituitary-intact rodents. We investigated the effect of peripheral administration of bovine growth hormone (bGH) on cellular proliferation in various regions of the brains of normal adult female rats. To monitor cell division, bromodeoxyuridine (BrdU) was administered daily for 5days. We studied the two areas of ongoing neurogenesis, the subventricular zone (SVZ) and the dentate gyrus (DG) of the hippocampus, as well as the corpus callosum, striatum, and the parietal and piriform co... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3221446 Mon, 25 Jan 2010 00:00:00 +0100 3221446 http://www.medworm.com/index.php?rid=3198237&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20089431%26dopt%3DAbstract Conclusions: IGF-II and the anti-apoptotic proteins differential expression among AA and CA patients may contribute to the breast cancer survival disparities observed between these ethnic groups. PMID: 20089431 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3198237 Tue, 19 Jan 2010 00:00:00 +0100 3198237 http://www.medworm.com/index.php?rid=3167534&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20060348%26dopt%3DAbstract CONCLUSION: In rats with aortic stenosis-induced heart failure, growth hormone administration increases MyoD gene expression above non-treated animal levels, preserves muscular trophism and attenuates interstitial fibrosis. These results suggest that growth hormone may have a potential role as an adjuvant therapy for chronic heart failure. PMID: 20060348 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3167534 Wed, 06 Jan 2010 00:00:00 +0100 3167534 http://www.medworm.com/index.php?rid=3136236&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20044290%26dopt%3DAbstract Authors: Lioi SA, Rigalli A, Puche RC The intravenous administration of rhGH (recombinant human Growth Hormone) to fasting female rats causes an increase in the rate of synthesis and secretion of VLDL (very low density lipoproteins). This phenomenon has three striking characteristics: (1) the demonstration of an unexpected lipogenic effect of rhGH, (2) its rapid occurrence after intravenous injection of the hormone and (3) the apparent dependence on the levels of circulating estrogens, as deduced by the lack of effect of rhGH on males and castrated females. The target tissue for the lipogenic effect was traced to the intestine by means of perfusion experiments of isolated duodenal loops. Impairment of liver blood supply discarded this tissue as the source of VLDL induced by rhGH. After... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3136236 Tue, 29 Dec 2009 00:00:00 +0100 3136236 http://www.medworm.com/index.php?rid=3136235&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20044291%26dopt%3DAbstract CONCLUSION: Despite marginal reductions in total IGF-I and -II, bioactive and free IGF-I declined markedly during and after HD. This is likely a consequence of the increase in IGFBP-1, sequestering free IGF-I, and reducing bioactive IGF-I. Based on the present data we hypothesize that the catabolism induced by HD is in part related to the observed reductions in bioactive IGF-I. PMID: 20044291 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3136235 Tue, 29 Dec 2009 00:00:00 +0100 3136235 http://www.medworm.com/index.php?rid=3120963&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20031461%26dopt%3DAbstract Authors: Suetta C, Clemmensen C, Andersen JL, Magnusson SP, Schjerling P, Kjaer M Hypertrophy of developing skeletal muscle involves stimulation by insulin-like growth factor-I (IGF-I), however, the role of IGF-I in adult muscle is less clarified. In the present study, the mRNA splice variants of IGF-I (IGF-IEa and MGF) and the changes in muscle fiber cross sectional area after 12weeks of training were studied in elderly post-operative patients. About 28 subjects, 14 men and 14 women (age 69, range 60-86 years) were randomized to unilateral resistance training (RT: 3/week), electrical stimulation (ES: 1h/day) or functional exercises (FE: 1h/day). The non-operated-side served as a within subject control. Muscle biopsies were obtained from the vastus lateralis of both limbs at +2d post-o... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3120963 Mon, 21 Dec 2009 00:00:00 +0100 3120963 http://www.medworm.com/index.php?rid=3108808&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20022776%26dopt%3DAbstract Authors: Myrelid A, Frisk P, Stridsberg M, Annerén G, Gustafsson J Down syndrome (DS) is associated with short stature and obesity. Adults with DS have several features in common with growth hormone (GH) deficient adult subjects. The aim of this study was to investigate GH secretion in young adults with DS and its relation to body composition as well as glucose and lipid metabolism. Ten young adults with DS (aged 24-32years; 5 F) and ten controls matched for age and sex were examined regarding spontaneous nocturnal GH secretion and body composition. Stable isotope tracers were used to study glucose and lipid metabolism in the DS subjects. There was no difference in secretion of GH between the DS subjects and controls. The DS subjects had a higher BMI, fat mass proportion and HOMA ... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3108808 Fri, 18 Dec 2009 00:00:00 +0100 3108808 http://www.medworm.com/index.php?rid=3108809&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20022531%26dopt%3DAbstract CONCLUSION: These results show that several components of the main GH-signaling pathways exhibit enhanced sensitivity to the hormone in liver and muscle of Ames dwarf mice. PMID: 20022531 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3108809 Thu, 17 Dec 2009 00:00:00 +0100 3108809 http://www.medworm.com/index.php?rid=3101281&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20005140%26dopt%3DAbstract CONCLUSION: A low IGF-I level is associated with hypercapnia presumably by reducing ventilatory drive and favouring muscle weakness. The relationship between increased triglycerides and low IGF-I may represent one of mechanisms involved in the OHS increased cardio-vascular risk. PMID: 20005140 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3101281 Thu, 10 Dec 2009 00:00:00 +0100 3101281 http://www.medworm.com/index.php?rid=3068076&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19962924%26dopt%3DAbstract In this study we demonstrated that IGF-II (1-87), as an abundant "big" IGF-II form, exists at a molar ratio of 0.24 (CI 0.13-0.62) with respect to mature IGF-II in the normal human circulation. Mature and "big" IGF-II can equally form complexes with IGFBP-2 and IGFBP-3 in vitro, resulting in the inhibition of IGF-II's biological function. However, under physiological conditions which entails the presence of both "big" and mature IGF-II, "big" IGF-IIs preferably formed complexes with IGFBP-3 but not IGFBP-2, unlike mature IGF-II which was equally associated with both IGFBP-3 and IGFBP-2. "Big" IGF-II binding to IGFBP-2 was only evident when the "big"/mature IGF-II ratio approached 1 or higher. We concluded that mature IGF-II prevents the formation of "big" IGF-II/IGFBP-2 complex in the circ... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3068076 Thu, 03 Dec 2009 00:00:00 +0100 3068076 http://www.medworm.com/index.php?rid=3052880&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19945319%26dopt%3DAbstract Authors: Interlichia JP, Williams NG, Rodgers BD One of the most accurate indices of changes in somatic tissue growth rate in rodents is the width of tibial epiphyseal plates as unlike most mammals, rodent growth plates never ossify. Unfortunately, the original procedure to measure tibial epiphyseal plate width (TEPW) was developed for rats and yields poor results with mice. This paper demonstrates a simple method for silver staining growth plates that can be used to inexpensively and quickly measure the TEPW of mice. Poor visualization due to overstaining and the shattering of growth plates necessitated several revisions to the original protocol. These include exposing the growth plate prior to acetone dehydration, reducing the silver nitrate concentration from 2% to 1.5% and staining... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3052880 Thu, 26 Nov 2009 00:00:00 +0100 3052880 http://www.medworm.com/index.php?rid=3027322&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19932628%26dopt%3DAbstract We examined the relationships between RA-induced protein kinase C (PKC)-delta, the secretion and synthesis of IGF-I, and oxidative stress. RA at 10(-8)M and 10(-7)M increased PKC-delta phosphorylation (the ratio of phosphorylated to total PKC-delta) (p<0.05) and decreased the secretion and synthesis of IGF-I (p<0.05) compared to control, with the effects peaking for treatment with 10(-7)M RA for 72h. The silencing of PKC-delta prevented the RA-induced inhibition of the secretion and synthesis of IGF-I and cell viability (p<0.05). Application of 10(-7)M RA for 72h increased the level of thiobarbituric-acid-reactive substances and the expression of inducible nitric oxide synthase relative to control (p<0.05). These increases were blocked by suppressing PKC-delta and by pretreatme... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3027322 Fri, 20 Nov 2009 00:00:00 +0100 3027322 http://www.medworm.com/index.php?rid=3027321&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19932629%26dopt%3DAbstract CONCLUSIONS: IGF-1 and IGFBP-3 levels seem to be independent of renal function and severity of proteinuria. However, ALS levels are altered in renal failure and nephrotic syndrome, which may be due to increased renal loss or diminished hepatic production or both. PMID: 19932629 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=3027321 Fri, 20 Nov 2009 00:00:00 +0100 3027321 http://www.medworm.com/index.php?rid=2963794&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19884028%26dopt%3DAbstract CONCLUSIONS: Our study confirmed that acromegalic patients have an increased proportion of circulating 20kDa-hGH isoform. Consequently, the use of a 22kDa-hGH specific assay may underestimate the tumor production of total GH. Although octreotide LAR promoted a significant decrease in the GH and IGF-I levels, it did not normalize the GH isoforms composition and suggests that the secretion of GH isoforms is equally inhibited by somatostatin analogues and that it is the disease control that normalizes the GH isoforms composition in acromegaly. PMID: 19884028 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2963794 Sat, 31 Oct 2009 00:00:00 +0100 2963794 http://www.medworm.com/index.php?rid=2931558&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19853487%26dopt%3DAbstract In this study, we investigated the relationship between pomegranate-induced apoptosis in human prostate cancer cells and the IGF/IGFBP system. Treatment of LAPC4 prostate cancer cells with 10mug/ml POMx, a highly potent pomegranate extract prepared from skin and arils minus seeds and standardized to ellagitannin content (37% punicalagins by HPLC), resulted in inhibition of cell proliferation and induction of apoptosis. Interestingly, co-treatment with POMx and IGFBP-3 revealed synergistic stimulation of apoptosis and additive inhibition of cell growth. Western blot analysis revealed that treatment with POMx or POMx/IGFBP-3 combination resulted in increased JNK phosphorylation, and decreased Akt and mTOR activation, consistent with a growth inhibitory, pro-apoptotic function. We also invest... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2931558 Wed, 21 Oct 2009 00:00:00 +0100 2931558 http://www.medworm.com/index.php?rid=2891521&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19818658%26dopt%3DAbstract Authors: Frystyk J, Freda P, Clemmons DR For almost three decades, the measurement of circulating IGF-I has constituted a highly important biochemical tool in the management of GH disorders. In fact, in acromegaly the importance of circulating IGF-I has increased following the introduction of the GH receptor antagonist pegvisomant, as the use of this drug makes it impossible to use circulating GH as a monitor of disease activity. In addition, determination of circulating IGF-I constitutes a valuable scientific tool in various research areas, from epidemiological investigations through clinical trials and experimental studies. The multiple facets of IGF-I physiology and patho-physiology may explain why numerous endocrine laboratories have invested in IGF-I assays, by means of either in-... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2891521 Tue, 06 Oct 2009 23:00:00 +0100 2891521 http://www.medworm.com/index.php?rid=2891520&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19818659%26dopt%3DAbstract Authors: Bidlingmaier M, Freda PU Measuring the concentration of growth hormone (GH) in blood samples taken during dynamic tests represents the basis for diagnosis of growth hormone related disorders, namely growth hormone deficiency and growth hormone excess. Today, a wide spectrum of immunoassays are in use, enabling rapid and sensitive determination of growth hormone concentrations in routine diagnostics. From a clinical point of view several difficulties exist with the use and interpretation of GH assay results in the assessment of GH related disorders: Many physiological factors such as fat mass, age and gender influence the outcome of dynamic tests, overall leading to significant inter-individual differences in GH responses. However, in addition to the physiological variability, ... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2891520 Tue, 06 Oct 2009 23:00:00 +0100 2891520 http://www.medworm.com/index.php?rid=2866489&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19800825%26dopt%3DAbstract CONCLUSION: The increased number of BrdU-positive cells in the granule cell layer suggests a partial restoration in the pool of proliferating cells by hexarelin after IR. PMID: 19800825 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2866489 Wed, 30 Sep 2009 23:00:00 +0100 2866489 http://www.medworm.com/index.php?rid=2866490&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19800274%26dopt%3DAbstract Authors: Vijayakumar A, Novosyadlyy R, Wu Y, Yakar S, Leroith D This review will summarize the metabolic effects of growth hormone (GH) on the adipose tissue, liver, and skeletal muscle with focus on lipid and carbohydrate metabolism. The metabolic effects of GH predominantly involve the stimulation of lipolysis in the adipose tissue resulting in an increased flux of free fatty acids (FFAs) into the circulation. In the muscle and liver, GH stimulates triglyceride (TG) uptake, by enhancing lipoprotein lipase (LPL) expression, and its subsequent storage. The effects of GH on carbohydrate metabolism are more complicated and may be mediated indirectly via the antagonism of insulin action. Furthermore, GH has a net anabolic effect on protein metabolism although the molecular mechanisms of i... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2866490 Tue, 29 Sep 2009 23:00:00 +0100 2866490 http://www.medworm.com/index.php?rid=2801124&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19747867%26dopt%3DAbstract Authors: Longo KA, Berryman DE, Kelder B, Charoenthongtrakul S, Distefano PS, Geddes BJ, Kopchick JJ The goal of this study was to examine factors that contribute to energy balance in female GHR -/- mice. We measured energy intake, energy expenditure (EE), fuel utilization, body mass (M(b)) changes and physical activity in 17month-old female GHR -/- mice and their age-matched wild type littermates. The GHR -/- mice were smaller, consumed more food per unit M(b), had greater EE per unit M(b) and had an increase in 24-h EE/M(b) that was similar to the increase in their surface-area-to-volume ratio. Locomotor activity (LMA) was reduced in the GHR -/- mice, but the energetic cost associated with their LMA was greater than in wild type controls. Furthermore, M(b) and LMA were independent ex... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2801124 Tue, 08 Sep 2009 23:00:00 +0100 2801124 http://www.medworm.com/index.php?rid=2738446&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19703789%26dopt%3DAbstract CONCLUSIONS: In summary, we provide evidence that E2F1 regulates IGF-IR gene transcription in prostate cancer cells via a mechanism that involves direct binding to specific elements in the proximal IGF-IR promoter. PMID: 19703789 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2738446 Fri, 21 Aug 2009 23:00:00 +0100 2738446 http://www.medworm.com/index.php?rid=2731002&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19699127%26dopt%3DAbstract CONCLUSION: These findings suggest that OC-DDTs could modulate the IGF-system in a way that is highly influenced by gender and age. Improvements in our understanding of exogenous determinants of the IGF-system may provide new insights into the role played by environmental contaminants in IGF-related diseases. PMID: 19699127 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2731002 Tue, 18 Aug 2009 23:00:00 +0100 2731002 http://www.medworm.com/index.php?rid=2725632&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19695914%26dopt%3DAbstract CONCLUSION: The data suggest male and female fetuses institute different strategies in response to adverse pregnancy conditions such as asthma and cigarette use. PMID: 19695914 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2725632 Mon, 17 Aug 2009 23:00:00 +0100 2725632 http://www.medworm.com/index.php?rid=2700475&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19674922%26dopt%3DAbstract CONCLUSIONS: These results provide evidence for an involvement of PGs in the regulation of growth as well as the GH-IGF and HPA axes. Therefore, early postnatal exposure to PG inhibitors may further exacerbate postnatal growth restriction and ability to cope with stress. PMID: 19674922 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2700475 Sun, 09 Aug 2009 23:00:00 +0100 2700475 http://www.medworm.com/index.php?rid=2684011&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19660970%26dopt%3DAbstract CONCLUSION: Short time discontinuation of HRT in young hypopituitary women increased liver enzymes, whereas measures of insulin sensitivity and lipid levels remained unchanged. We speculate that the estrogen component of HRT has beneficial effects on hepatic metabolism through various pathways. Further studies including liver imaging and with a time-dependent design are needed to clarify the role of HRT on liver enzyme levels, metabolic variables and liver fat content. PMID: 19660970 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2684011 Mon, 03 Aug 2009 23:00:00 +0100 2684011 http://www.medworm.com/index.php?rid=2679123&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19656700%26dopt%3DAbstract CONCLUSIONS: This study demonstrates that TGF-beta1 modulates the expression of IGFBP-4 and PAPP-A in cultured periosteal explants. PMID: 19656700 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2679123 Sun, 02 Aug 2009 23:00:00 +0100 2679123 http://www.medworm.com/index.php?rid=2622702&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19615927%26dopt%3DAbstract CONCLUSION: GH modulates the development of acute pancreatitis in the presence of active sensory nerves probably via stimulation of IGF-1 release. PMID: 19615927 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2622702 Tue, 14 Jul 2009 23:00:00 +0100 2622702 http://www.medworm.com/index.php?rid=2615820&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19608446%26dopt%3DAbstract This article provides an overview of legal considerations in anti-doping procedures that may apply to the use of the marker method for the detection of Human Growth Hormone. In cases where the blood markers IGF-1 and P-III-P indicate use of exogenous growth hormone, reference to positivity criteria and laboratory uncertainty measurements would assist anti-doping adjudicative bodies in concluding, to their comfortable satisfaction, that a positive test has been established. Use of established positivity criteria and laboratory uncertainty measurements place the application of the marker method for growth hormone within the existing, accepted legal framework for evaluating an Adverse Analytical Finding. PMID: 19608446 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Re... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2615820 Mon, 13 Jul 2009 23:00:00 +0100 2615820 http://www.medworm.com/index.php?rid=2570462&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19574074%26dopt%3DAbstract Authors: Cowan DA, Bartlett C Two important biomarkers for the identification of growth hormone or IGF-I administration are IGF-I and P-III-P. These substances are determined in plasma or preferably in serum. There are a number of assays on the market for IGF-I but only two for P-III-P. The principles behind these assays and the choice of assays for doping control purposes are discussed. The future possibility of quantification by mass spectrometry is also briefly discussed. PMID: 19574074 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2570462 Mon, 29 Jun 2009 23:00:00 +0100 2570462 http://www.medworm.com/index.php?rid=2561714&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19560381%26dopt%3DAbstract CONCLUSION: These results contribute to a better understanding of metabolic glycemic disorders in HIV-1-infected pregnant women using ARV, showing that IGF-2/ApaI polymorphisms are not responsible as a single causative factor of glycemic alterations. These data indicate that other variables should be studied in order to explain these glycemic abnormalities. PMID: 19560381 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2561714 Wed, 24 Jun 2009 23:00:00 +0100 2561714 http://www.medworm.com/index.php?rid=2532939&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19535276%26dopt%3DAbstract Authors: Sonksen PH, Holt RI PMID: 19535276 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532939 Mon, 15 Jun 2009 23:00:00 +0100 2532939 http://www.medworm.com/index.php?rid=2532937&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19539504%26dopt%3DAbstract Authors: Pinsent M PMID: 19539504 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532937 Mon, 15 Jun 2009 23:00:00 +0100 2532937 http://www.medworm.com/index.php?rid=2532935&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19539505%26dopt%3DAbstract Authors: Graham MR, Baker JS, Evans P, Hullin D, Thomas NE, Davies B Athletes have enjoyed almost a thirty year amnesty of rhGH abuse, which they consider has contributed to the winning of medals and the breaking of world records. Such a reprieve is almost at an end, since WADA have identified a method to detect rhGH abuse. Or have they? The anecdotal word "on the street" is that rhGH is still undetectable and athletes believe that the benefits, at the dosages they administer, far outweigh the risks! Scientists are aware that in a hormone deficiency condition, replacement can halt and in certain situations reverse some of the adverse effects. Growth hormone deficiency can lead to a loss of skeletal muscle mass and an increase in abdomino-visceral obesity, which is reversed on replaceme... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532935 Mon, 15 Jun 2009 23:00:00 +0100 2532935 http://www.medworm.com/index.php?rid=2532933&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19539506%26dopt%3DAbstract CONCLUSIONS: Specific cleavage of IGFBP-1 occurs at the tissue level and not in the circulation in a patient with multiple myeloma and dermatitis. The fragments that are generated may have endocrine roles. PMID: 19539506 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532933 Mon, 15 Jun 2009 23:00:00 +0100 2532933 http://www.medworm.com/index.php?rid=2532941&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19524466%26dopt%3DAbstract CONCLUSION: These results indicate a novel role for GH and its receptor in injury-induced neurogenesis, and suggest that GH treatment may potentiate endogenous neuro-restorative processes after brain injury. PMID: 19524466 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532941 Wed, 10 Jun 2009 23:00:00 +0100 2532941 http://www.medworm.com/index.php?rid=2532943&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19515593%26dopt%3DAbstract Authors: Bassett EE, Erotokritou-Mulligan I The detection of growth hormone (GH) abuse by athletes raises statistical problems as well as biochemical ones. We outline the statistical approaches to the various issues which have arisen during the work of the GH-2000 and GH-2004 teams; in particular, it considers the need to develop a test which detects GH abuse in any elite athlete 'beyond reasonable doubt'. The test needs to be robust enough to withstand legal challenge, while minimising the risk of false accusation. The paper identifies various issues which arise in the development of such a test, and describes how these were resolved. Since GH is a naturally occurring hormone whose concentration varies substantially, its abuse cannot be detected by direct measurement. The methodology ... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532943 Sun, 07 Jun 2009 23:00:00 +0100 2532943 http://www.medworm.com/index.php?rid=2532947&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19502089%26dopt%3DAbstract Authors: Sharp RJ PMID: 19502089 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532947 Fri, 05 Jun 2009 23:00:00 +0100 2532947 http://www.medworm.com/index.php?rid=2532945&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19505835%26dopt%3DAbstract Authors: Widdowson WM, Healy ML, Sönksen PH, Gibney J The growth hormone (GH)/ insulin-like growth factor-I (IGF-I) axis exerts short-and long-term metabolic effects that are potentially important during exercise. Exercise is a potent stimulus to GH release and there is some evidence that the acute increase in GH is important in regulating substrate metabolism post-exercise. Regular exercise also increases 24-hour GH secretion rates, which potentially contributes to the physiologic changes induced by training. The effects of GH replacement in GH-deficient adults provide a useful model with which to study the effects of the more long-term effects of the GH/ IGF-I axis. There is convincing evidence that GH replacement increases exercise capacity. Measures of exercise performance inc... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532945 Fri, 05 Jun 2009 23:00:00 +0100 2532945 http://www.medworm.com/index.php?rid=2532949&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19501005%26dopt%3DAbstract Authors: Goodbody J PMID: 19501005 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532949 Wed, 03 Jun 2009 23:00:00 +0100 2532949 http://www.medworm.com/index.php?rid=2532951&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19501004%26dopt%3DAbstract Authors: Ding J, List EO, Okada S, Kopchick JJ Several serum biomarkers for recombinant human growth hormone (rhGH) have been established, however, none alone or in combination have generate a specific, sensitive, and reproducible 'kit' for the detection of rhGH abuse. Thus, the search for additional GH specific biomarkers continues. In this review, we focus on the use of proteomics in general and two-dimensional electrophoresis (2-DE) in particular for the discovery of new GH induced serum biomarkers. Also, we review some of the protocols involved in 2-DE. Finally, the possibility of tissues other than blood for biomarker discovery is discussed. PMID: 19501004 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532951 Tue, 02 Jun 2009 23:00:00 +0100 2532951 http://www.medworm.com/index.php?rid=2532957&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19487144%26dopt%3DAbstract CONCLUSIONS: In 2008 significant progress has been made; there is one test for detecting HGH approved for use in anti-doping and a second detection method pending. This is a strong reflection of the ongoing research efforts in anti-doping and the progress being made by the Anti-Doping Organisations in reducing the risk that doping poses to sport. PMID: 19487144 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532957 Fri, 29 May 2009 23:00:00 +0100 2532957 http://www.medworm.com/index.php?rid=2532956&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19487145%26dopt%3DAbstract In this report, we review studies of its biological effect, measurement and secretion. To use serum 20K-GH level in detecting GH abuse, new method has been established and serum 22K-GH, 20K-GH were measured in normal subjects and athletes, and no abnormal results were found among athletes. Another study confirmed that serum 22K-GH increased remarkably and 20K-GH decreased following the exogenous administration of 22K-GH. The duration was relatively short, approximately 24-36h in our and other studies. The increase of the ratio, 22K-GH/20K-GH was the most suitable indicator of GH abuse. Studies supported by the WADA were undertaken in collaboration with an Australian Group. A new approach for the GH isoform assay by beads assay platform is being developed. It is concluded that the direct me... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532956 Fri, 29 May 2009 23:00:00 +0100 2532956 http://www.medworm.com/index.php?rid=2532955&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19487146%26dopt%3DAbstract Authors: Rogol AD There is great interest among athletes and in the sports and general media for the subject of "doping" with human growth hormone (hGH). The hype about this substance goes far beyond the available data. The issue of administration of recombinant rhGH to adolescents, whether for athletic performance or for esthetic purposes adds another wrinkle because normal pubertal growth and the acquisition of adult body composition depends upon the GH/IGF-I and the hypothalamic-pituitary-gonadal axes. The range of normal is wide and it is more difficult to determine the natural evolution of pubertal development from that fueled by rhGH (or anabolic steroids). There are no compelling data based on clinical trials to indicate enhanced athletic performance (young adults); however, one... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532955 Fri, 29 May 2009 23:00:00 +0100 2532955 http://www.medworm.com/index.php?rid=2532953&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19487147%26dopt%3DAbstract Authors: Harridge SD, Velloso CP Gene doping is the term given to the potential misuse of gene therapy for the purposes of enhancing athletic performance. Insulin like growth factor-I (IGF-I), the prime target of growth hormone action, is one candidate gene for improving performance. In recent years a number of transgenic and somatic gene transfer studies on animals have shown that upregulation of IGF-I stimulates muscle growth and improves function. This increase in muscle IGF-I is not reflected in measurable increases in circulating IGF-I. Whilst the responses obtained in the animal studies would appear to give clear benefits for performance, the transfer of such techniques to humans still presents many technical challenges. Further challenges will also be faced by the anti doping au... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532953 Fri, 29 May 2009 23:00:00 +0100 2532953 http://www.medworm.com/index.php?rid=2532958&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19482501%26dopt%3DAbstract Authors: Barroso O, Schamasch P, Rabin O Due to its considered performance enhancing effects, human growth hormone (hGH) is abused as a doping agent in sport. Its misuse also carries potentially serious side effects to a person's health. Consequently, hGH and its releasing factors are prohibited in sport, as established in the Prohibited List which is updated and published yearly by the World Anti-Doping Agency (WADA). In order to fight the menace that hGH doping poses to the spirit of sport and to the health of athletes, the sport movement and the anti-doping authorities, initially led by the International Olympic Committee (IOC) and later by WADA, have put substantial efforts into developing tests for its detection. Currently, a primary analytical approach, the isoform differential i... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532958 Thu, 28 May 2009 23:00:00 +0100 2532958 http://www.medworm.com/index.php?rid=2532959&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19481485%26dopt%3DAbstract In conclusion, age and gender are the major determinants of variability for IGF-I and the collagen markers, whereas ethnicity and sport type have a minor influence. Therefore, a test based on IGF-I and the collagen markers must take age into account for men and women, and ethnicity and sport type are unlikely to be confounders for these markers. PMID: 19481485 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532959 Tue, 26 May 2009 23:00:00 +0100 2532959 http://www.medworm.com/index.php?rid=2532960&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19477668%26dopt%3DAbstract Authors: Ehrnborg C, Rosén T Drugs and methods to improve physical performance among athletes have been used since the beginning of sport history, but the use of performance enhancing drugs has not always been regarded as cheating. In short, the motives for doping are improving and maintaining physical functioning, coping with the social/psychological pressures and striving for social and psychological goals, including economic benefits. Factors such as, "doping dilemma", "win at all costs", cost versus benefit, and the specificity of some specific doping agents, also play major roles. It seems that action on the athletes' attitude about the achievement of physical improvement and creating effective methods to reveal the drug abuse, are two main ways in winning the struggle agains... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532960 Mon, 25 May 2009 23:00:00 +0100 2532960 http://www.medworm.com/index.php?rid=2532962&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19473863%26dopt%3DAbstract Authors: Gutiérrez-Gallego R, Bosch J, Such-Sanmartín G, Segura J Human growth hormone (GH) represents an extremely challenging task from an anti-doping viewpoint. GH is an endogenously produced substance, present at very low levels in circulation (for the most abundant 22kDa isoform approximately 50pM in plasma and 100fM in urine) either as monomer or homo- and heterodimers, comprises a family of distinct isoforms, and obeys a pulsatile secretion routine that is affected by many different internal and external factors. Upon administration of the recombinant, single-isoform pharmaceutical, the feedback mechanism reduces the endogenous heterogeneity resulting in altered ratios between the different GH isoforms. Thus, measuring the isoform ratios through immuno assays appears t... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532962 Sun, 24 May 2009 23:00:00 +0100 2532962 http://www.medworm.com/index.php?rid=2532961&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19473864%26dopt%3DAbstract Authors: Sonksen P The IOC recognised growth hormone (GH) as a drug of abuse in 1992 and recruited me as an expert to advise them on the development of a test to detect its abuse. After a long gestation period where the IOC gradually changed their attitude to research they co-funded the GH-2000 project with the European Union (EU). GH-2000 was a unique consortium of Europe's best endocrinologists and scientists in partnership with two GH manufacturers and the IOC with a greater than two million dollar budget. GH-2000 selected a method based on the measurement of GH-dependent markers and selected IGF-I and P-III-P as the most suitable markers and demonstrated that they could detect 100% of men taking GH with a false-positive rate better than 1:10,000; sensitivity was reduced however in ... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532961 Sun, 24 May 2009 23:00:00 +0100 2532961 http://www.medworm.com/index.php?rid=2532966&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19467614%26dopt%3DAbstract Authors: Baumann GP Human growth hormone (GH) is a heterogeneous protein hormone consisting of several isoforms. The sources of this heterogeneity reside at the level of the genome, mRNA splicing, post-translational modification and metabolism. The GH gene cluster on chromosome 17q contains 2 GH genes (GH1 or GH-N and GH2 or GH-V) in addition to 2(-3) genes encoding the related chorionic somatomammotropin. Alternative mRNA splicing of the GH1 transcript yields two products: 22K-GH (the principal pituitary GH form) and 20K-GH. Post-translationally modified GH forms include N(alpha)-acylated, deamidated and glycosylated monomeric GH forms, as well as both non-covalent and disulfide-linked oligomers up to at least pentameric GH. GH fragments generated in the course of peripheral metabolis... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532966 Sat, 23 May 2009 23:00:00 +0100 2532966 http://www.medworm.com/index.php?rid=2532968&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19467612%26dopt%3DAbstract Authors: Holt RI, Erotokritou-Mulligan I, Sönksen PH The earliest records of doping in sport come from the Ancient Olympics games when athletes are reported to have taken figs to improve their performance. With the advent of modern pharmacology in the 19th century, many athletes began to experiment with cocktails of drugs to improve strength and overcome fatigue. As this practice was not illegal, there are good records of the lengths athletes would go to in order to win. Alongside the benefits, came the dangers and following several fatalities, a code to ban performance enhancing drugs was gradually developed. Growth hormone was first isolated from the human pituitary gland in the 1950s. Its anabolic effects were soon recognised and athletes had begun to abuse it by the early 1980... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532968 Fri, 22 May 2009 23:00:00 +0100 2532968 http://www.medworm.com/index.php?rid=2532967&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19467613%26dopt%3DAbstract Authors: Holt RI, Bassett EE, Erotokritou-Mulligan I, McHugh C, Cowan D, Bartlett C, Sönksen PH, Growth hormone is abused by athletes for its anabolic and lipolytic properties. The detection of GH abuse is challenging because it is an endogenous hormone whose concentration varies widely in any one day. The GH-2000 project proposed a test based on the measurement of IGF-I and type III pro-collagen (P-III-P). When the results of the GH-2000 project were presented to an expert workshop, the method was supported but it was felt that several issues needed to be resolved before the method could be adopted. The first was a potential effect of ethnicity as most subjects in the GH-2000 were white Europeans and the second was a possible effect of injury as P-III-P is a marker of soft tissu... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532967 Fri, 22 May 2009 23:00:00 +0100 2532967 http://www.medworm.com/index.php?rid=2532965&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19467615%26dopt%3DAbstract Authors: Guha N, Sönksen PH, Holt RI As the tests for detecting growth hormone (GH) abuse develop further, it is likely that athletes will turn to doping with insulin-like growth factor-I (IGF-I). IGF-I mediates many of the anabolic actions of growth hormone. It stimulates muscle protein synthesis, promotes glycogen storage and enhances lipolysis, all of which make IGF-I attractive as a potential performance-enhancing agent. Pharmaceutical companies have developed commercial preparations of recombinant human IGF-I (rhIGF-I) for use in disorders of growth. The increased availability of rhIGF-I increases the opportunity for athletes to acquire supplies of the drug on the black market. The long-term effects of IGF-I administration are currently unknown but it is likely that these wil... Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532965 Fri, 22 May 2009 23:00:00 +0100 2532965 http://www.medworm.com/index.php?rid=2532964&cid=s_35589_15_f&fid=35589&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19467616%26dopt%3DAbstract This article gives an overview of the potential application of surface-enhanced laser desorption/ionization time-of-flight (SELDI-TOF) mass spectrometry to examine proteomic changes following GH administration, using both serum and white blood cell extracts as samples for analysis. Results to date indicate that proteomic changes observed following GH administration have the potential to yield novel biomarker sets for the detection of GH abuse. PMID: 19467616 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research) Growth Hormone and IGF Research journals http://www.medworm.com/rss/comments.php?id=2532964 Fri, 22 May 2009 23:00:00 +0100 2532964