MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Gynecologic Oncology' source. Wed, 08 Feb 2012 08:41:34 +0100 http://www.medworm.com/index.php?rid=5624886&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22264601%26dopt%3DAbstract Authors: Karlan BY PMID: 22264601 [PubMed - in process] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5624886 Tue, 24 Jan 2012 23:31:26 +0100 5624886 http://www.medworm.com/index.php?rid=5624885&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22264602%26dopt%3DAbstract Authors: Nelson BH PMID: 22264602 [PubMed - in process] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5624885 Tue, 24 Jan 2012 23:31:15 +0100 5624885 http://www.medworm.com/index.php?rid=5624884&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22264603%26dopt%3DAbstract Authors: Pennington KP, Swisher EM Abstract In the past, hereditary ovarian carcinoma was attributed almost entirely to mutations in BRCA1 and BRCA2, with a much smaller contribution from mutations in DNA mismatch repair genes. Recently, three new ovarian cancer susceptibility genes have been identified: RAD51C, RAD51D, and BRIP1. In addition, germline mutations in women with ovarian carcinoma have been recently identified in many of the previously identified breast cancer genes in the Fanconi anemia (FA)-BRCA pathway. While mutations in genes other than BRCA1 and BRCA2 are each individually rare, together they make up a significant proportion of cases. With at least 16 genes implicated in hereditary ovarian cancer to date, comprehensive testing for ovarian cancer risk will require... Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5624884 Tue, 24 Jan 2012 23:31:04 +0100 5624884 http://www.medworm.com/index.php?rid=5624883&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22266023%26dopt%3DAbstract Authors: Cliby W, Aletti G, Chi D, Bristow R PMID: 22266023 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5624883 Wed, 18 Jan 2012 05:00:00 +0100 5624883 http://www.medworm.com/index.php?rid=5624882&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22266548%26dopt%3DAbstract CONCLUSIONS: This review indicates that the hrHPV test should be included in post-treatment testing 6 months after treatment, because hrHPV testing has a higher sensitivity than cytology in detecting high-grade post-treatment disease and has a similar specificity. PMID: 22266548 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5624882 Tue, 17 Jan 2012 05:00:00 +0100 5624882 http://www.medworm.com/index.php?rid=5624881&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22266549%26dopt%3DAbstract Authors: Lim MC, Park SY PMID: 22266549 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5624881 Tue, 17 Jan 2012 05:00:00 +0100 5624881 http://www.medworm.com/index.php?rid=5624880&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22266550%26dopt%3DAbstract CONCLUSIONS: Our study shows methylation for one or more methylation markers in all vulvar cancers. Despite a specificity of 100% our panel of three methylation markers had only moderate sensitivity for metastatic lymph node detection, thereby limiting its applicability for lymph node assessment. Intratumor heterogeneity for expression of P16INK4a and MGMT may reflect intratumor heterogeneity for methylation patterns and thereby in general explain the moderate sensitivity of our marker panel for detection of metastases. PMID: 22266550 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5624880 Tue, 17 Jan 2012 05:00:00 +0100 5624880 http://www.medworm.com/index.php?rid=5624879&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22266551%26dopt%3DAbstract CONCLUSION: Cervical adenocarcinomas are more common in younger women and white patients. Adenocarcinoma histology negatively impacts survival for both early and advanced-stage carcinomas. PMID: 22266551 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5624879 Tue, 17 Jan 2012 05:00:00 +0100 5624879 http://www.medworm.com/index.php?rid=5624889&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22261299%26dopt%3DAbstract CONCLUSION: Although operative times were longer and risk for superficial wound separation was significantly higher, pelvic exenteration appears to be feasible and safe in overweight and obese women with overall complication rates and survival outcomes comparable to normal weight women. PMID: 22261299 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5624889 Mon, 16 Jan 2012 05:00:00 +0100 5624889 http://www.medworm.com/index.php?rid=5624888&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22261300%26dopt%3DAbstract CONCLUSIONS: Surgical and oncologic outcomes of laparoscopic radical hysterectomy were not worse at a cancer center in a developing country than at a large comprehensive cancer center in the United States. These results support consideration of developing countries for inclusion in collaborations for prospective surgical studies. PMID: 22261300 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5624888 Mon, 16 Jan 2012 05:00:00 +0100 5624888 http://www.medworm.com/index.php?rid=5624887&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22261301%26dopt%3DAbstract CONCLUSIONS: ERCC1 expression, measured by IHC in pre-treatment tumor specimens, using a highly specific antibody, has limited clinical value in patients with advanced EOC treated with platinum and taxane based chemotherapy. PMID: 22261301 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5624887 Mon, 16 Jan 2012 05:00:00 +0100 5624887 http://www.medworm.com/index.php?rid=5624892&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22252097%26dopt%3DAbstract CONCLUSION: These findings provide the initial basis for further evaluation of minocycline in the treatment of ovarian cancer. PMID: 22252097 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5624892 Sat, 14 Jan 2012 05:00:00 +0100 5624892 http://www.medworm.com/index.php?rid=5624891&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22252098%26dopt%3DAbstract CONCLUSIONS: Our data suggest that programs can enhance research producitivity with the incorporation of accountability features including formalized reports of progress and mentorship feedback in fellowship training. Facilitating the identification of a mentor and providing an additional year of research may be independent factors associated with research productivity. PMID: 22252098 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5624891 Sat, 14 Jan 2012 05:00:00 +0100 5624891 http://www.medworm.com/index.php?rid=5624890&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22252099%26dopt%3DAbstract CONCLUSIONS: Metformin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and modulation of the mTOR pathway. This combination may be a promising targeted therapy for endometrial cancer. PMID: 22252099 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5624890 Sat, 14 Jan 2012 05:00:00 +0100 5624890 http://www.medworm.com/index.php?rid=5624893&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22245711%26dopt%3DAbstract CONCLUSION: Based on this systematic review of the contemporary literature, endometrial hyperplasia has a significantly higher likelihood of response (66%) to hormonal therapy than grade 1 endometrial carcinoma (48%). Disease persistence is more common in women with carcinoma (25%) compared to hyperplasia (14%). Reproductive outcomes do not seem to differ between the cohorts. PMID: 22245711 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5624893 Wed, 11 Jan 2012 05:00:00 +0100 5624893 http://www.medworm.com/index.php?rid=5624894&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240566%26dopt%3DAbstract CONCLUSION: High- and medium-volume gynecologic laparoscopists performed a greater proportion of intermediate- and high-complexity procedures than did low-volume surgeons. High-volume surgeons have a lower rate of conversions, overall postoperative complications, and shorter mean length of hospital stay when compared to low volume surgeons. PMID: 22240566 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5624894 Tue, 10 Jan 2012 05:00:00 +0100 5624894 http://www.medworm.com/index.php?rid=5624897&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22233688%26dopt%3DAbstract Re: "Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy as upfront therapy for advanced epithelial ovarian cancer: Multi-institutional phase II trial." - Proposal of a clinical trial of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in advanced ovarian cancer, the CHORINE study. Gynecol Oncol. 2012 Jan 9; Authors: Ansaloni L, De Iaco P, Frigerio L PMID: 22233688 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5624897 Mon, 09 Jan 2012 05:00:00 +0100 5624897 http://www.medworm.com/index.php?rid=5624896&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22233689%26dopt%3DAbstract CONCLUSIONS: These data corroborate the suitability of AHPV for the primary cervical cancer screening. PMID: 22233689 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5624896 Mon, 09 Jan 2012 05:00:00 +0100 5624896 http://www.medworm.com/index.php?rid=5624895&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22233690%26dopt%3DAbstract CONCLUSIONS: We found no cases of endometrial cancer amongst 260 women presenting with postmenopausal vaginal bleeding under the age of 50years. These women could be investigated on a less urgent basis depending on the available resources. PMID: 22233690 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5624895 Sun, 08 Jan 2012 05:00:00 +0100 5624895 http://www.medworm.com/index.php?rid=5578984&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22226807%26dopt%3DAbstract Letter-to-the Editor "Trends in treatment of advanced epithelial ovarian cancer in the Medicare population" Gynecol Oncol. 2012 Jan 5; Authors: Thrall MM, Gray HJ, Goff BA PMID: 22226807 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5578984 Thu, 05 Jan 2012 05:00:00 +0100 5578984 http://www.medworm.com/index.php?rid=5578983&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22226808%26dopt%3DAbstract CONCLUSIONS: In the population we studied, the proportion of women with infection by different genotypes of HPV 16 and HPV 18 was high. This finding confirms the need for further studies to compare the efficacy and protection of current vaccines against intraepithelial lesions and cervical cancer. PMID: 22226808 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5578983 Thu, 05 Jan 2012 05:00:00 +0100 5578983 http://www.medworm.com/index.php?rid=5578985&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22226684%26dopt%3DAbstract CONCLUSIONS: HPV-positive early stage (FIGO I and II) VaSCC have a better prognosis than early HPV-negative tumors. HPV detection and/or p16(INK4a) immunostaining can be easily implemented in routine pathology and should be considered as valuable prognostic biomarkers in the study of patients with VaSCC. PMID: 22226684 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5578985 Wed, 04 Jan 2012 05:00:00 +0100 5578985 http://www.medworm.com/index.php?rid=5536839&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22153125%26dopt%3DAbstract Authors: Vergote I, Leunen K, Amant F PMID: 22153125 [PubMed - in process] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536839 Sat, 24 Dec 2011 14:52:04 +0100 5536839 http://www.medworm.com/index.php?rid=5536838&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22153126%26dopt%3DAbstract Authors: Burger RA PMID: 22153126 [PubMed - in process] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536838 Sat, 24 Dec 2011 14:51:55 +0100 5536838 http://www.medworm.com/index.php?rid=5536819&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22178239%26dopt%3DAbstract CONCLUSIONS: Increased adrenomedullin expression may result in amplifying both tumorigenic and angiogenic activities. A substantial impact on growth of tumours may result in vivo as a consequence of the synergism between adrenomedullin and VEGF. Adrenomedullin, which has altered cellular characteristics in tumour compared to healthy tissue, offers an understudied target with potential to modify endometrial cancer behaviour, complementing other treatments. PMID: 22178239 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536819 Thu, 15 Dec 2011 05:00:00 +0100 5536819 http://www.medworm.com/index.php?rid=5536818&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22178761%26dopt%3DAbstract CONCLUSION: The result of this conservative treatment for EST of the vagina is excellent. BEP chemotherapy without surgery should be considered as a good choice of treatment. Closely follow up with serial determinations of serum AFP level together with imaging tests and physical examination in the first two years of follow-up are recommended. PMID: 22178761 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536818 Wed, 14 Dec 2011 05:00:00 +0100 5536818 http://www.medworm.com/index.php?rid=5536821&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22173089%26dopt%3DAbstract Authors: Canis M, Querleu D, Pomel C PMID: 22173089 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536821 Mon, 12 Dec 2011 05:00:00 +0100 5536821 http://www.medworm.com/index.php?rid=5536822&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22166844%26dopt%3DAbstract CONCLUSIONS: This series confirms that modified VRAM flaps can be used successfully at the time of exenteration, even in an increasingly high risk patient population with an acceptable risk for flap complications. PMID: 22166844 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536822 Sat, 10 Dec 2011 05:00:00 +0100 5536822 http://www.medworm.com/index.php?rid=5536837&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22155260%26dopt%3DAbstract CONCLUSION: Combination treatment with carboplatin and retinoids reduced cell-viability, reduced CSC marker expression, and inhibited tumorigenicity, making it a more effective treatment when compared with carboplatin alone. PMID: 22155260 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536837 Fri, 09 Dec 2011 05:00:00 +0100 5536837 http://www.medworm.com/index.php?rid=5536836&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22155261%26dopt%3DAbstract CONCLUSION: We have developed an all-stage nomogram to predict 5-year disease-specific mortality after primary surgery for epithelial ovarian cancer. This tool is more accurate than FIGO staging and should be useful for patient counseling, clinical trial eligibility, postoperative management, and follow-up. PMID: 22155261 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536836 Fri, 09 Dec 2011 05:00:00 +0100 5536836 http://www.medworm.com/index.php?rid=5536835&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22155262%26dopt%3DAbstract CONCLUSIONS: Paclitaxel at 175mg/m(2) IV, carboplatin AUC 6 IP day 1 and paclitaxel 60mg/m(2) IP day 8 yields 18-56% patients with DLTs. The tolerability of the regimen in combination with bevacizumab was indicated in a small cohort. PMID: 22155262 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536835 Fri, 09 Dec 2011 05:00:00 +0100 5536835 http://www.medworm.com/index.php?rid=5536825&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22155795%26dopt%3DAbstract CONCLUSIONS: Our study showed a 34% rate of discordance between FS and final diagnosis. Given that 5 cases (7%) were of GI origin, intraoperative assessment of the appendix should be performed in all mucinous ovarian tumors. PMID: 22155795 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536825 Fri, 09 Dec 2011 05:00:00 +0100 5536825 http://www.medworm.com/index.php?rid=5536824&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22155796%26dopt%3DAbstract CONCLUSIONS: AEH comprises cases which may constitute a low risk group involving <40% of AEH cases. These cases hold a percentage of <20% of nuclei of a preneoplastic phenotype. AEH cases from the central and high end of progression have >40% of nuclei of preneoplastic phenotype. Nuclei of the preneoplastic phenotype in AEH lesions are almost indistinguishable from nuclei in SIEC, where this percentage exceeds 60%. The percentage of nuclei of the preneoplastic phenotype in AEH lesions might serve as criterion for assessment of risk for the development of invasive disease. PMID: 22155796 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536824 Fri, 09 Dec 2011 05:00:00 +0100 5536824 http://www.medworm.com/index.php?rid=5536830&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22155674%26dopt%3DAbstract CONCLUSION: Our results indicate that the immune system does not seem to have a major influence on prognosis of patients with vulvar squamous carcinoma. PMID: 22155674 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536830 Thu, 08 Dec 2011 05:00:00 +0100 5536830 http://www.medworm.com/index.php?rid=5536829&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22155675%26dopt%3DAbstract CONCLUSIONS: Ovarian carcinosarcomas are rare and aggressive tumors, associated with a poor prognosis. The mainstay of treatment remains cytoreductive surgical effort for metastatatic disease followed by platinum-based chemotherapy. The role of targeted therapies may be promising in the treatment of OCS. PMID: 22155675 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536829 Thu, 08 Dec 2011 05:00:00 +0100 5536829 http://www.medworm.com/index.php?rid=5536828&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22155676%26dopt%3DAbstract CONCLUSION: If the effect of a new drug treatment for ovarian cancer is to extend median PFS by x months, then it is reasonable to estimate that the treatment will also extend median overall survival by x months. This information will be useful for individual and collective decision making. PMID: 22155676 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536828 Thu, 08 Dec 2011 05:00:00 +0100 5536828 http://www.medworm.com/index.php?rid=5536827&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22155677%26dopt%3DAbstract CONCLUSIONS: The pattern of regional spread in cervical cancer can be comprehended and predicted from ontogenetic lymphatic compartments. In patients with early cervical cancer lymph node dissection based on ontogenetic anatomy achieves high regional tumor control without adjuvant radiation. PMID: 22155677 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536827 Thu, 08 Dec 2011 05:00:00 +0100 5536827 http://www.medworm.com/index.php?rid=5536826&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22155678%26dopt%3DAbstract CONCLUSIONS: The presence of CSI and increasing number of PPN were associated with poor prognosis. On average, patients with CSI experienced improved PFS and OS when treated with AP relative to WAI. PMID: 22155678 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536826 Thu, 08 Dec 2011 05:00:00 +0100 5536826 http://www.medworm.com/index.php?rid=5536823&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22155797%26dopt%3DAbstract CONCLUSIONS: The majority of women surveyed experienced persistent psychological and physical symptoms following ovarian cancer treatment; in particular: psychological concerns, sexual inactivity and fatigue, all potentially reversible with appropriate interventions. Our results highlight the extent of symptoms described by ovarian cancer survivors and the need for them to be adequately acknowledged and addressed. PMID: 22155797 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536823 Thu, 08 Dec 2011 05:00:00 +0100 5536823 http://www.medworm.com/index.php?rid=5536834&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22155415%26dopt%3DAbstract CONCLUSIONS: Patients with H-IR disease based on uterine characteristics alone have substantial risk of nodal involvement. Knowledge of LN status may better define risk, prognosis, and postoperative treatment. PMID: 22155415 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536834 Tue, 06 Dec 2011 05:00:00 +0100 5536834 http://www.medworm.com/index.php?rid=5536833&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22155416%26dopt%3DAbstract Authors: Markman M PMID: 22155416 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536833 Tue, 06 Dec 2011 05:00:00 +0100 5536833 http://www.medworm.com/index.php?rid=5536832&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22155417%26dopt%3DAbstract Authors: Schummer M, Drescher C, Forrest R, Gough S, Thorpe J, Hellström I, Hellström KE, Urban N PMID: 22155417 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536832 Tue, 06 Dec 2011 05:00:00 +0100 5536832 http://www.medworm.com/index.php?rid=5536831&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22155418%26dopt%3DAbstract CONCLUSION: This assembly by the ACR of physicians involved in the management of patients with early stage cervical cancer was able to describe appropriateness criteria to aid other practitioners in selecting reasonable implementation of postoperative therapies and subsequent surveillance studies. These guidelines await further validation and refinement by both current and future prospectively randomized clinical studies regarding this patient population. PMID: 22155418 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536831 Tue, 06 Dec 2011 05:00:00 +0100 5536831 http://www.medworm.com/index.php?rid=5536840&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22146569%26dopt%3DAbstract CONCLUSIONS: The increased expression of ER stress markers in endometrioid endometrial carcinomas suggests a role for ER stress, the UPR and, possibly, GRP78 in endometrial cancer. Whether this mechanisms have a substantial function in the pathogenesis of malignant transformation of human endometrium is still under investigation in our laboratory. PMID: 22146569 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536840 Sat, 03 Dec 2011 05:00:00 +0100 5536840 http://www.medworm.com/index.php?rid=5536817&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22188785%26dopt%3DAbstract CONCLUSIONS: Withaferin A inhibits CaOV3 and SKOV3 ovarian carcinoma cell growth, at least in part by targeting Notch1 and Notch3. PMID: 22188785 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536817 Sat, 03 Dec 2011 05:00:00 +0100 5536817 http://www.medworm.com/index.php?rid=5536841&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22138373%26dopt%3DAbstract CONCLUSIONS: Single agent aflibercept has modest activity in patients with uterine leiomyosarcoma and minimal activity in women with carcinosarcoma. PMID: 22138373 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536841 Thu, 01 Dec 2011 05:00:00 +0100 5536841 http://www.medworm.com/index.php?rid=5536816&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22188786%26dopt%3DAbstract CONCLUSIONS: These results suggest that testing HR-HPV positive at any time point during FU is the most significant independent predictor of progressive disease, while showing free margins in cone has a significant protective effect against progression to AC. Furthermore, because 4.3% women with persistent, recurrent or progressive disease experienced a late (5th and 6th FU) diagnosis of HG-CGIN or microinvasive AC, a close surveillance should be scheduled for at least three years in conservatively treated AIS patients. PMID: 22188786 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536816 Thu, 01 Dec 2011 05:00:00 +0100 5536816 http://www.medworm.com/index.php?rid=5536844&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22138228%26dopt%3DAbstract CONCLUSIONS: Delayed reporting and late-stage presentation of late rectal sequelae are more prevalent among Chinese cervical cancer patients with 55years or older, low education, poor marital status, or poor financial status. Effective social support and educational programs should be implemented to encourage these patients to seek medical treatment as soon as possible. PMID: 22138228 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536844 Wed, 30 Nov 2011 05:00:00 +0100 5536844 http://www.medworm.com/index.php?rid=5536843&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22138229%26dopt%3DAbstract CONCLUSIONS: In this study, disease assessment by RECIST and CA-125 appear to correlate in general. However, approximately 10% of patients might demonstrate progression earlier by CA-125. PMID: 22138229 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536843 Wed, 30 Nov 2011 05:00:00 +0100 5536843 http://www.medworm.com/index.php?rid=5536842&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22138230%26dopt%3DAbstract CONCLUSION: More older women with ovarian cancer are receiving hospice care over time, however, a substantial proportion receive such care very near death, and sociodemographic disparities in hospice care exist. Our data also support the need to target lower-income and minority women in efforts to increase optimally timed hospice referrals in this population. Our finding that ovarian cancer patients enrolled in managed care plans were more likely to receive hospice care suggests the importance of health care system factors in the utilization of hospice services. PMID: 22138230 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536842 Wed, 30 Nov 2011 05:00:00 +0100 5536842 http://www.medworm.com/index.php?rid=5536845&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22138013%26dopt%3DAbstract CONCLUSION: Economic burden of breast cancer extends into post-treatment survivorship. Better understanding of economic impact and managing economic burden may help maintain QOL. PMID: 22138013 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536845 Tue, 29 Nov 2011 05:00:00 +0100 5536845 http://www.medworm.com/index.php?rid=5536847&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22134374%26dopt%3DAbstract CONCLUSIONS: Our results do not suggest that the common genetic variation of CD83 is related to cervical or vulvar cancers. The association between tagSNP rs853360 and risk of cervical SCC is likely to be due to chance. If larger or pooled studies confirm our results, CD83 has little or no influence in the risk of HPV-related cancers. PMID: 22134374 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536847 Mon, 28 Nov 2011 05:00:00 +0100 5536847 http://www.medworm.com/index.php?rid=5536846&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22134375%26dopt%3DAbstract CONCLUSION: Gynecological cancer survivors experience a broad range of sexual concerns after diagnosis and treatment, but the majority of studies emphasized physical aspects of sexuality, and may not adequately represent women's psychological and social sexual concerns. Health care providers should remain mindful of psychological and social sexual concerns when caring for gynecologic cancer survivors. Future research should systematically evaluate the full range of sexual concerns in large, representative samples of GYN cancer survivors and develop and test interventions to address those concerns. PMID: 22134375 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536846 Mon, 28 Nov 2011 05:00:00 +0100 5536846 http://www.medworm.com/index.php?rid=5536849&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22120175%26dopt%3DAbstract CONCLUSION: Presence of micrometastasis in SN in patients with early stage cervical cancer was associated with significant reduction of overall survival, which was equivalent to patients with macrometastasis. No prognostic significance was found for ITC. These data highlight the importance of SN biopsy and pathologic ultrastaging for the management of cervical cancer. PMID: 22120175 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536849 Fri, 25 Nov 2011 05:00:00 +0100 5536849 http://www.medworm.com/index.php?rid=5536848&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22120176%26dopt%3DAbstract CONCLUSIONS: Our data showed that the direct costs and charges associated with robotic surgery were higher compared to laparoscopic surgery. However, actual reimbursements to the hospital, surgeon, and anesthesiologist were not significantly different between the two surgical approaches. PMID: 22120176 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536848 Fri, 25 Nov 2011 05:00:00 +0100 5536848 http://www.medworm.com/index.php?rid=5536855&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22119990%26dopt%3DAbstract CONCLUSIONS: HPV 16 and 18 accounted together for a 72.4% of positive cases, with no statistically significant changes in their relative contributions over the last decades. In 94% of cervical adenocarcinomas we identified at least one of the two HPV types included in the current vaccines (HPV 16/18). Results suggest a major impact of HPV vaccines on reduction of ICC burden in Spain in the HPV vaccinated cohorts. PMID: 22119990 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536855 Wed, 23 Nov 2011 05:00:00 +0100 5536855 http://www.medworm.com/index.php?rid=5536853&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22119992%26dopt%3DAbstract CONCLUSION: Women with gynecological cancers experience a plethora of late effects; however, very few of them have access to a survivorship plan to cope with these issues. Patient reported side effects, especially sexual dysfunction, occur more commonly than previously reported. Patient-focused tools to evaluate these side effects and access to survivorship plans are needed for comprehensive care of gynecologic cancer survivors. PMID: 22119992 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536853 Wed, 23 Nov 2011 05:00:00 +0100 5536853 http://www.medworm.com/index.php?rid=5536851&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22119994%26dopt%3DAbstract CONCLUSIONS: To enhance quality of life and to promote healthy lifestyle behavior of female cancer patients, particularly in younger age, it is essential to assure multidisciplinary approaches with specific medical intervention and psychosocial supports. Indeed, midlife adults seem to have a more rapid adaptive tendency to return towards levels of well-being, following cancer diagnosis and treatment, than younger patients. PMID: 22119994 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536851 Wed, 23 Nov 2011 05:00:00 +0100 5536851 http://www.medworm.com/index.php?rid=5536850&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22119995%26dopt%3DAbstract CONCLUSIONS: Poor physical well-being reported at baseline is associated with risk of death in patients undergoing adjuvant chemotherapy for advanced ovarian cancer. Identifying modifiable characteristics that are associated with survival offers the potential for providing support that may improve outcomes. PMID: 22119995 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536850 Wed, 23 Nov 2011 05:00:00 +0100 5536850 http://www.medworm.com/index.php?rid=5536860&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22115851%26dopt%3DAbstract CONCLUSIONS: Ixabepilone plus sunitinib demonstrated antitumor synergy via RhoB in naïve and paclitaxel-resistant cells resulting in apoptosis. This study demonstrates a novel mechanism of action leading to antitumor synergy and provides 'proof-of-principle' for combining molecular targeted agents with cytotoxic chemotherapy to improve antitumor efficacy. RhoB could be envisioned as an early biomarker of response to therapy in a planned Phase II clinical trial to assess the efficacy of ixabepilone combined with a receptor tyrosine kinase inhibitor such as sunitinib. To the best of our knowledge, this is the first demonstration of antitumor synergy between these two classes of drugs in EOC and the pivotal role of RhoB in this synergy. PMID: 22115851 [PubMed - as supplied by publisher] ... Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536860 Tue, 22 Nov 2011 05:00:00 +0100 5536860 http://www.medworm.com/index.php?rid=5536859&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22115852%26dopt%3DAbstract CONCLUSIONS: This study provides further evidence to support the feasibility of detecting altered DNA methylation patterns as a potential diagnostic and prognostic approach for HGSOC. PMID: 22115852 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536859 Tue, 22 Nov 2011 05:00:00 +0100 5536859 http://www.medworm.com/index.php?rid=5536858&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22115853%26dopt%3DAbstract CONCLUSIONS: Telomerase activity appears to correlate to the clinical aggressiveness seen in histologic subtypes of ovarian cancer. BIBR1532 demonstrated significant inhibition of TA as well as reasonable efficacy as a single agent. Inhibition of telomerase with BIBR1532 in combination with carboplatin demonstrated a more than additive effect in-vitro and could represent a novel targeted therapy for ovarian cancer. PMID: 22115853 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536858 Tue, 22 Nov 2011 05:00:00 +0100 5536858 http://www.medworm.com/index.php?rid=5536857&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22115854%26dopt%3DAbstract CONCLUSION: Chinese immigrant BCS may be at risk for greater distress compared with US-born Chinese and NHW BCS because of cultural norms that make them less inclined to express their needs to physicians or challenge physicians when their needs are not met. Furthermore, they may express symptoms in culturally unique ways (e.g., hot-cold imbalances). Further research is needed to determine how to best improve survivorship care experiences in this understudied population, with the goal of decreasing BCS' physical distress and improving quality of life. PMID: 22115854 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536857 Tue, 22 Nov 2011 05:00:00 +0100 5536857 http://www.medworm.com/index.php?rid=5536856&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22115855%26dopt%3DAbstract CONCLUSIONS: The high (>2%) cumulative 18-month CIN2/3+ risk in patients with presumed cervical and/or endometrial pathology warrants routine cervical testing. In these women a hrHPV-test should be added to cytology because this identifies a significant number of additional women with a substantial risk of CIN2/3+ lesions who would not be identified with cytology alone. Women referred for other reasons should not have cervical testing beforehand, because of their low risk of CIN2/3+. PMID: 22115855 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536856 Tue, 22 Nov 2011 05:00:00 +0100 5536856 http://www.medworm.com/index.php?rid=5536854&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22119991%26dopt%3DAbstract CONCLUSION: Overall, this study supports the feasibility of designing dietary interventions for stage II-IV ovarian cancer survivors and provides preliminary evidence that a low fat high fiber diet and a diet supplemented with encapsulated FVJC may increase phytonutrients in ovarian cancer survivors.Keywords ovarian cancer, lifestyle, nutrition, diet, cancer survivors, carotenoids, tocopherols, comparative effectiveness, and randomized study. PMID: 22119991 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536854 Tue, 22 Nov 2011 05:00:00 +0100 5536854 http://www.medworm.com/index.php?rid=5536852&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22119993%26dopt%3DAbstract CONCLUSIONS: ESS is a rare cancer that is difficult to study. We found removal of the adnexa and post-operative treatment with progestin therapy decreased recurrence rates. These two treatment strategies should be considered in the treatment of patients with all stages of ESS. PMID: 22119993 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536852 Tue, 22 Nov 2011 05:00:00 +0100 5536852 http://www.medworm.com/index.php?rid=5536820&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22173210%26dopt%3DAbstract Authors: Westphal LM, Wapnir IL Abstract Young women diagnosed with breast cancer typically face systemic treatments that may delay childbearing or permanently impair their fertility. These concerns add to the stress experienced by young cancer survivors. Timely counseling and providing fertility preservation through cryopreservation of eggs or embryos have become an important quality of life issue. We analyzed the impact of fertility preservation procedures on the initiation of treatment for breast cancer and discuss critical aspects of the process. PMID: 22173210 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536820 Tue, 22 Nov 2011 05:00:00 +0100 5536820 http://www.medworm.com/index.php?rid=5536863&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22112608%26dopt%3DAbstract CONCLUSION: Aflibercept 4mg/kg every 2weeks was effective at controlling malignant ascites, reducing the interval between repeat paracenteses. The safety profile was consistent with that reported for anti-VEGF agents. PMID: 22112608 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536863 Mon, 21 Nov 2011 05:00:00 +0100 5536863 http://www.medworm.com/index.php?rid=5536862&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22112609%26dopt%3DAbstract CONCLUSIONS: Patients with stage IC, grade 3 endometrial cancer had a significantly increased risk of recurrence (28.9%). All of these recurrences had a distant component and the majority were fatal. Further investigation into the addition of adjuvant systemic therapy in these high-risk patients is warranted. PMID: 22112609 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536862 Mon, 21 Nov 2011 05:00:00 +0100 5536862 http://www.medworm.com/index.php?rid=5536861&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22112610%26dopt%3DAbstract CONCLUSION: The C421A variant in ABCG2, previously shown to be associated with enhanced protein degradation and drug sensitivity, was associated with longer PFS in advanced stage EOC/PPC patents treated with platinum+taxane-based chemotherapy. This finding requires further validation. PMID: 22112610 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5536861 Mon, 21 Nov 2011 05:00:00 +0100 5536861 http://www.medworm.com/index.php?rid=5442113&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22108635%26dopt%3DAbstract CONCLUSION: Hypomethylated CpG around the transcription start site enables the expression of TERT in cervical cancer cells. Our results show for the first time HPV16 E6 can promote TERT transcription through demethylating the DNA sequence around the TERT transcription start site in cervical squamous cancer cells. PMID: 22108635 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5442113 Sat, 19 Nov 2011 05:00:00 +0100 5442113 http://www.medworm.com/index.php?rid=5442112&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22108636%26dopt%3DAbstract CONCLUSIONS: African Americans diagnosed with ovarian cancer have worse survival than whites, and this disparity has increased over time. Measured differences in treatment, such as receipt of surgery, account for part of the disparity. PMID: 22108636 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5442112 Sat, 19 Nov 2011 05:00:00 +0100 5442112 http://www.medworm.com/index.php?rid=5442116&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22108254%26dopt%3DAbstract CONCLUSION: Pathologic parameters in cone biopsy specimens can estimate the risk of residual invasive disease in radical hysterectomy specimens and the use of adjuvant chemo-radiation. PMID: 22108254 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5442116 Fri, 18 Nov 2011 05:00:00 +0100 5442116 http://www.medworm.com/index.php?rid=5442115&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22108255%26dopt%3DAbstract CONCLUSION: Clear histological criteria together with the use of Masson trichrome stains to distinguish smooth muscle from fibrous tissue improved concordance rates in identifying parametrial invasion by tumor to near 100% PMID: 22108255 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5442115 Fri, 18 Nov 2011 05:00:00 +0100 5442115 http://www.medworm.com/index.php?rid=5442114&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22108256%26dopt%3DAbstract CONCLUSION: Intraoperative FS performed better than preoperative TVS in the assessment of myometrial invasion by endometrial cancer. Despite being time-consuming, FS can be regarded as a useful modality in order to decide whether to perform lymphadenectomy in cases with poor visualization of the endometrium at TVS and when TVS gives inconclusive results. PMID: 22108256 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5442114 Fri, 18 Nov 2011 05:00:00 +0100 5442114 http://www.medworm.com/index.php?rid=5442120&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22101154%26dopt%3DAbstract CONCLUSION: Lymphatic ascites is an under recognized and infrequently reported postoperative complication. Although it usually resolves spontaneously or with conservative management without sequelae, this condition can significantly prolong postoperative recovery and cause patient discomfort. To our knowledge this is the largest group of patients undergoing gynecologic surgical staging procedures to be reviewed for the occurrence of lymphatic ascites. PMID: 22101154 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5442120 Thu, 17 Nov 2011 05:00:00 +0100 5442120 http://www.medworm.com/index.php?rid=5442119&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22101155%26dopt%3DAbstract CONCLUSION: Physical fitness levels were abysmal in these morbidly obese subjects and worse for cancer patients. Exercise correlated with improved body composition and vitality. PMID: 22101155 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5442119 Thu, 17 Nov 2011 05:00:00 +0100 5442119 http://www.medworm.com/index.php?rid=5442121&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22100838%26dopt%3DAbstract CONCLUSIONS: The FIGO 2009 staging system has improved prediction of prognosis, and is less complex, compared to earlier versions. Careful assessment of myometrial invasion seems particularly important for patients not subjected to lymphadenectomy. PMID: 22100838 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5442121 Wed, 16 Nov 2011 05:00:00 +0100 5442121 http://www.medworm.com/index.php?rid=5423791&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22094931%26dopt%3DAbstract CONCLUSIONS: The decline ratio in hCG level 2 weeks after evacuation in patients with complete molar pregnancies is the most reliable predictor of persistent GTN. Our analysis may allow clinicians to stratify risk in patients with complete molar pregnancies and to provide more accurate counseling based on the hCG levels obtained 2 weeks after evacuation. PMID: 22094931 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5423791 Mon, 14 Nov 2011 05:00:00 +0100 5423791 http://www.medworm.com/index.php?rid=5423790&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22094932%26dopt%3DAbstract CONCLUSIONS: Adequately powered longitudinal studies including formal neurocognitive and QOL assessments are needed to advance our understanding of the incidence of cognitive dysfunction and its impact on functional ability and QOL in ovarian cancer patients. These research efforts may ultimately contribute to treatment decision-making through the identification of vulnerable patients, and to the development of appropriate intervention strategies to improve cognitive function and QOL. PMID: 22094932 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5423790 Mon, 14 Nov 2011 05:00:00 +0100 5423790 http://www.medworm.com/index.php?rid=5423792&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22085894%26dopt%3DAbstract CONCLUSION: ER/PR expression is associated with survival outcomes in patients with high-grade uterine LMS confined to the uterine body. PR expression seems capable of identifying cases confined to the uterine body, which have better outcomes. PMID: 22085894 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5423792 Sat, 12 Nov 2011 05:00:00 +0100 5423792 http://www.medworm.com/index.php?rid=5423793&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22082991%26dopt%3DAbstract CONCLUSION: Surgery for bowel obstruction in relapsed EOC is associated with a high morbidity and mortality rate especially in emergency cases when compared to other gynaecological oncological procedures. Palliation can be achieved in almost two thirds of cases, is equally likely in elective and emergency cases but is less likely in those with ascites. PMID: 22082991 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5423793 Fri, 11 Nov 2011 05:00:00 +0100 5423793 http://www.medworm.com/index.php?rid=5423795&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22079678%26dopt%3DAbstract CONCLUSIONS: Clinical and pathologic parameters can predict response to progestin therapy in premenopausal women with CAH and Grade 1 EA. A low likelihood of resolution is predicted by an unfavorable pre-treatment architectural score and lack of pathological response in the first specimen, despite adjacent stromal decidualization. PMID: 22079678 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5423795 Wed, 09 Nov 2011 05:00:00 +0100 5423795 http://www.medworm.com/index.php?rid=5423794&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22079679%26dopt%3DAbstract Authors: Ramirez PT, Adams S, Boggess JF, Burke WM, Frumovitz MM, Gardner GJ, Havrilesky LJ, Holloway R, Lowe MP, Magrina JF, Moore DH, Soliman PT, Yap S PMID: 22079679 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5423794 Wed, 09 Nov 2011 05:00:00 +0100 5423794 http://www.medworm.com/index.php?rid=5423799&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22079359%26dopt%3DAbstract CONCLUSION: Transarterial chemoembolization is effective palliative treatment in achieving local control in selected patients with liver metastases from ovarian cancer. PMID: 22079359 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5423799 Tue, 08 Nov 2011 05:00:00 +0100 5423799 http://www.medworm.com/index.php?rid=5423798&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22079360%26dopt%3DAbstract CONCLUSIONS: Low-risk GTN is reliably and rapidly cured with combined methotrexate-dactinomycin. Toxicity is modest. PMID: 22079360 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5423798 Tue, 08 Nov 2011 05:00:00 +0100 5423798 http://www.medworm.com/index.php?rid=5423797&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22079361%26dopt%3DAbstract CONCLUSIONS: This combination of radiation therapy plus weekly cisplatin successfully yielded high complete clinical and pathologic response rates with acceptable toxicity. PMID: 22079361 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5423797 Tue, 08 Nov 2011 05:00:00 +0100 5423797 http://www.medworm.com/index.php?rid=5423796&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22079362%26dopt%3DAbstract CONCLUSIONS: Both the quantitative and qualitative results in our study suggest that quality of care for endometrial cancer survivors must begin to shift from a purely disease-focused approach to a wellness-centered approach that provides coordinated, patient-centered, comprehensive care and more formalized transition care planning. PMID: 22079362 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5423796 Tue, 08 Nov 2011 05:00:00 +0100 5423796 http://www.medworm.com/index.php?rid=5423800&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22075241%26dopt%3DAbstract CONCLUSIONS: Exercisers identified outcomes of exercise that are more immediate and subjective as being important and likely outcomes of exercise. Focusing on these aspects of exercise (feeling better physically and emotionally) may aid in the development of effective interventions for non-exercisers. PMID: 22075241 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5423800 Mon, 07 Nov 2011 05:00:00 +0100 5423800 http://www.medworm.com/index.php?rid=5423804&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22062546%26dopt%3DAbstract CONCLUSIONS: Among unscreened women, HC2 and HC2+4 had similar screening accuracy for cervical neoplasia, and both were more sensitive but less specific than Pap cytology. PMID: 22062546 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5423804 Fri, 04 Nov 2011 04:00:00 +0100 5423804 http://www.medworm.com/index.php?rid=5423803&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22063459%26dopt%3DAbstract CONCLUSION: While our pilot study is not large enough to assess sensitivity or specificity of a symptom-based screening approach, we did find that this type of screening was feasible and acceptable at the time of a primary care visit and referred approximately 4% of women for additional diagnostic testing. Symptom-based screening also resulted in minimal additional procedures. PMID: 22063459 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5423803 Fri, 04 Nov 2011 04:00:00 +0100 5423803 http://www.medworm.com/index.php?rid=5423802&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22063460%26dopt%3DAbstract This study's objective was to quantify the impact (utility) of common complications of early cervical cancer treatment on quality of life (QOL). Utilities assigned by survivors were compared to those assigned by providers. METHODS: 30 survivors of early cervical cancer identified from our Tumor Registry and 10 gynecologic oncology providers were interviewed. Participants evaluated complications (health states) using the standard gamble (SG) and visual analogue scale (VAS). Each participant was randomly assigned to rate 5 of 13 health states. Mixed-effects linear models were used to generate confidence intervals for utility means, and evaluate the effect of group (survivors versus providers). Higher utilities indicate the health state is closer to perfect health. RESULTS: Survivors and prov... Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5423802 Fri, 04 Nov 2011 04:00:00 +0100 5423802 http://www.medworm.com/index.php?rid=5423801&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22063461%26dopt%3DAbstract CONCLUSION: No consistent association between any gene polymorphism and clinical outcome in gynecological cancers has been found across studies. There is incomplete adherence to the REMARK guidelines and inadequate methodology reporting in most studies. Moving forward, analysis of large trial-based clinical samples; adherence to the highest methodological standards, and focus on validation analyses are necessary to identify clinically useful pharmacogenomic biomarkers of outcome. PMID: 22063461 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5423801 Fri, 04 Nov 2011 04:00:00 +0100 5423801 http://www.medworm.com/index.php?rid=5423808&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22055763%26dopt%3DAbstract CONCLUSIONS: In this economic model, dose-dense weekly paclitaxel is a cost-effective treatment option for advanced ovarian cancer. PMID: 22055763 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5423808 Thu, 03 Nov 2011 04:00:00 +0100 5423808 http://www.medworm.com/index.php?rid=5423807&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22055764%26dopt%3DAbstract CONCLUSIONS: There were no differences detected in survival between patients who required dose adjustments and treatment delays and those who did not. The lack of association between survival and chemotherapy alterations suggests that in specific circumstances patients with advanced ovarian cancer should have individualized treatment plans. PMID: 22055764 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5423807 Thu, 03 Nov 2011 04:00:00 +0100 5423807 http://www.medworm.com/index.php?rid=5423806&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22055846%26dopt%3DAbstract CONCLUSIONS: Ifosfamide "sandwiched" with RT appears to be an efficacious regimen for surgically staged CS patients with no residual disease, even in patients with advanced stage. The addition of cisplatin to the regimen added toxicity without improving efficacy. Even with ifosfamide alone, the efficacy of this 'sandwich' regimen comes with a moderate but tolerable toxicity profile. PMID: 22055846 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5423806 Wed, 02 Nov 2011 04:00:00 +0100 5423806 http://www.medworm.com/index.php?rid=5423805&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22056554%26dopt%3DAbstract Authors: Zhou J, Peng C, Li B, Wang F, Zhou C, Hong D, Ye F, Cheng X, Lü W, Xie X Abstract OBJECTIVE: Transcriptional silencing of HPV oncogenes using short interfering RNA (siRNA) blocks E6/E7 expression. Our objective was to estimate the effective value of E6/E7 specific siRNA-induced transcriptional gene silencing as a potential therapeutic strategy for cervical cancer. METHODS: In vitro studies were performed by employing two categories of siRNA targeting promoter of E6/E7 gene and E7 transcript, respectively, and inhibitory effect of both siRNAs was further observed in vitro and on xenograft in BALB/c mice that were inoculated with siRNA transfected SiHa cells and parental SiHa cells followed by siRNA intratumoral injection in vivo. Tumor volume and growth curves were assesse... Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5423805 Wed, 02 Nov 2011 04:00:00 +0100 5423805 http://www.medworm.com/index.php?rid=5382111&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22047770%26dopt%3DAbstract CONCLUSIONS: Although well tolerated, the tanespimycin/gemcitabine combination exhibited limited anticancer activity in patients with advanced epithelial ovarian and primary peritoneal carcinoma, perhaps because of failure to significantly downregulate the client proteins at clinically achievable exposures. PMID: 22047770 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5382111 Tue, 01 Nov 2011 04:00:00 +0100 5382111 http://www.medworm.com/index.php?rid=5346369&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22008409%26dopt%3DAbstract Authors: Nicol AF, Monsonego J PMID: 22008409 [PubMed - in process] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5346369 Tue, 25 Oct 2011 17:07:51 +0100 5346369 http://www.medworm.com/index.php?rid=5346359&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22018873%26dopt%3DAbstract CONCLUSIONS: The present data suggest that TWIST2 overexpression was significantly linked to cervical cancer progression, which makes it a promising marker for determining the metastatic potential of cervical cancer, and up-regulation of TWIST2, in combination with aberrant E-cadherin expression in primary cervical cancer tissues, may predict the malignant transformation and distal metastasis of carcinomas. PMID: 22018873 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5346359 Fri, 21 Oct 2011 04:00:00 +0100 5346359 http://www.medworm.com/index.php?rid=5346355&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22020038%26dopt%3DAbstract Authors: Spillman MA PMID: 22020038 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5346355 Thu, 20 Oct 2011 04:00:00 +0100 5346355 http://www.medworm.com/index.php?rid=5346358&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22019525%26dopt%3DAbstract CONCLUSIONS: The outcomes of patients with GCTs were good, with nearly to 95% of patients surviving 5 and 10years. The prognosis was related to initial stage, presence of residual tumor after initial surgery, and tumor size (> 13.5cm). Different surgical methods and/or adjuvant therapy appear not to affect the outcome. PMID: 22019525 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5346358 Wed, 19 Oct 2011 04:00:00 +0100 5346358 http://www.medworm.com/index.php?rid=5346357&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22019526%26dopt%3DAbstract Authors: Manchanda R, Drapkin R, Jacobs I, Menon U PMID: 22019526 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5346357 Wed, 19 Oct 2011 04:00:00 +0100 5346357 http://www.medworm.com/index.php?rid=5346356&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22019527%26dopt%3DAbstract CONCLUSION: Keratosis reduces the sensitivity of anal cytology. Furthermore, anal cytology poorly correlates with anoscopy in the detection of AIN (κ statistic = -0.0213). PMID: 22019527 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5346356 Wed, 19 Oct 2011 04:00:00 +0100 5346356 http://www.medworm.com/index.php?rid=5346367&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22014627%26dopt%3DAbstract CONCLUSION: Pelvic exenteration for recurrent uterine malignancies can be associated with long-term survival in properly selected patients. A high rate of postoperative complications remains a hallmark of this procedure and should be discussed carefully with patients facing this decision. PMID: 22014627 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5346367 Tue, 18 Oct 2011 04:00:00 +0100 5346367 http://www.medworm.com/index.php?rid=5346366&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22014628%26dopt%3DAbstract CONCLUSIONS.: This pilot survey sheds a light on attitudes and practices about the end-of-life discussion that deserve to be further studied. PMID: 22014628 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5346366 Tue, 18 Oct 2011 04:00:00 +0100 5346366 http://www.medworm.com/index.php?rid=5346365&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22014629%26dopt%3DAbstract Authors: Zannoni GF, Scambia G, Gallo D PMID: 22014629 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5346365 Tue, 18 Oct 2011 04:00:00 +0100 5346365 http://www.medworm.com/index.php?rid=5346364&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22014630%26dopt%3DAbstract CONCLUSION: We may conclude that conservative management of stage IA2 MIC is safe when exact evaluation of tumor extension and surgical margins of the cone are considered, and results in very low risk of recurrence, lymph node disease, and death caused by cancer. We believe that our experience will contribute to the achievement of the international consensus concerning the treatment of IA2 MIC. PMID: 22014630 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5346364 Tue, 18 Oct 2011 04:00:00 +0100 5346364 http://www.medworm.com/index.php?rid=5346363&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22014631%26dopt%3DAbstract CONCLUSIONS: A higher pre-treatment circulating monocyte count is independently associated with poor prognosis in patients with locally advanced cervical squamous cell carcinoma. The pre-treatment circulating monocyte count may be considered as an adjunctive biomarker with SCC-Ag. PMID: 22014631 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5346363 Tue, 18 Oct 2011 04:00:00 +0100 5346363 http://www.medworm.com/index.php?rid=5346360&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22015044%26dopt%3DAbstract CONCLUSION: Overexpression of SNCG seemed to be a predictor biomarker for aggressive tumor behavior and adverse outcome in patients with endometrial cancer. Future exploration of SNCG as a potential therapeutic target for selected patients could be of interest. PMID: 22015044 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5346360 Tue, 18 Oct 2011 04:00:00 +0100 5346360 http://www.medworm.com/index.php?rid=5346362&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22015042%26dopt%3DAbstract CONCLUSIONS: Primary radiation therapy for clinical stage I and II EAC is a feasible option for medically inoperable patients and provides disease control, with fewer than 16% of surviving patients experiencing recurrence. PMID: 22015042 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5346362 Mon, 17 Oct 2011 04:00:00 +0100 5346362 http://www.medworm.com/index.php?rid=5346361&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22015043%26dopt%3DAbstract CONCLUSION: The interaction between miR-200c and BRD7 might have important roles in controlling growth of endometrial of cancer cells and suggest a novel target pathway for treatment of this cancer. PMID: 22015043 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5346361 Mon, 17 Oct 2011 04:00:00 +0100 5346361 http://www.medworm.com/index.php?rid=5346374&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22004903%26dopt%3DAbstract CONCLUSIONS: Our results indicate that induction of ovarian-specific autoimmunity may serve as an effective way to prevent the emergence of autochthonous ovarian tumors and control the growth of established ovarian malignancies. PMID: 22004903 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5346374 Sun, 16 Oct 2011 04:00:00 +0100 5346374 http://www.medworm.com/index.php?rid=5346373&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22004904%26dopt%3DAbstract CONCLUSIONS: This study shows that the addition of concurrent chemotherapy to postoperative RT in cervical cancer patients with intermediate risk factors may improve RFS without increasing acute GI and chronic toxicities, although hematologic toxicities increased significantly. PMID: 22004904 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5346373 Sun, 16 Oct 2011 04:00:00 +0100 5346373 http://www.medworm.com/index.php?rid=5346368&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22008707%26dopt%3DAbstract CONCLUSIONS: The present findings indicate that a low preoperative ADCmin of the primary tumor is an important predictive factor for identifying endometrial cancer patients with a risk of disease recurrence. PMID: 22008707 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5346368 Sat, 15 Oct 2011 04:00:00 +0100 5346368 http://www.medworm.com/index.php?rid=5346375&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22001143%26dopt%3DAbstract CONCLUSION: AR expression correlates with increased S-phase fraction in response to androgenic stimulation. Immunohistochemical analysis of AR expression needs to be further tested in clinical trials to select AR positive EOC for anti-androgen therapy. Anti-androgen use early in the course of ovarian cancer is more likely to be effective as these data suggest that androgen receptor expression decreases with exposure to chemotherapy and this may explain the low response rates seen in clinical trials of patients heavily pre-treated with multiple courses of chemotherapy. PMID: 22001143 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5346375 Fri, 14 Oct 2011 04:00:00 +0100 5346375 http://www.medworm.com/index.php?rid=5346372&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22005521%26dopt%3DAbstract CONCLUSIONS: PTENP1 is expressed in NE and EMCA cell lines, as are PTEN/PTENP1 targeting inhibitory miRNAs (cell lines). Further studies are needed to evaluate the impact of PTEN/PTENP1/miRNA interactions on tumorigenesis regulation in EMCA. PMID: 22005521 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5346372 Fri, 14 Oct 2011 04:00:00 +0100 5346372 http://www.medworm.com/index.php?rid=5346371&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22005522%26dopt%3DAbstract CONCLUSIONS: Vitamin A intake and blood vitamin A levels were inversely associated with the risk of cervical cancer in this meta-analysis. PMID: 22005522 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5346371 Fri, 14 Oct 2011 04:00:00 +0100 5346371 http://www.medworm.com/index.php?rid=5346370&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22005523%26dopt%3DAbstract CONCLUSIONS: Downregulation of miR-130b promotes the development of multidrug resistant ovarian cancer partially by targeting the 3'-UTR of CSF-1, and the silencing of miR-130b may be mediated by DNA methylation. PMID: 22005523 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5346370 Fri, 14 Oct 2011 04:00:00 +0100 5346370 http://www.medworm.com/index.php?rid=5346376&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21999920%26dopt%3DAbstract CONCLUSION: These cross-sectional data suggest that withdrawal from familial ovarian cancer screening may be influenced by both clinical and psychological factors. These may reflect women's experience of the drawbacks of screening and increased concern about ovarian cancer risk, as well as having opportunities to consider surgery as an alternative risk management strategy whilst using screening as an interim measure. PMID: 21999920 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5346376 Thu, 13 Oct 2011 04:00:00 +0100 5346376 http://www.medworm.com/index.php?rid=5346381&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21996260%26dopt%3DAbstract CONCLUSION: There is no place for routine renal ultrasound following radical hysterectomy. Patients should be instructed about the symptoms that may be related to hydronephrosis, to allow for renal ultrasound on indication. PMID: 21996260 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5346381 Tue, 11 Oct 2011 04:00:00 +0100 5346381 http://www.medworm.com/index.php?rid=5346380&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21996261%26dopt%3DAbstract The "luxury" of second malignancies. Gynecol Oncol. 2011 Oct 11; Authors: Armstrong DK, Visvanathan K PMID: 21996261 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5346380 Tue, 11 Oct 2011 04:00:00 +0100 5346380 http://www.medworm.com/index.php?rid=5346379&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21996262%26dopt%3DAbstract CONCLUSIONS: A 1mg cervical injection of ICG identified a SLN in 88% of patients (95% CI is (64%, 99%)). Robotically assisted fluorescence imaging is a feasible, safe, time efficient and reliable method for lymphatic mapping in early stage cervical and endometrial cancer. PMID: 21996262 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5346379 Tue, 11 Oct 2011 04:00:00 +0100 5346379 http://www.medworm.com/index.php?rid=5346378&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21996263%26dopt%3DAbstract CONCLUSIONS: Although a second stage of accrual was not indicated based on the overall response rate, the drug was well tolerated. PMID: 21996263 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5346378 Tue, 11 Oct 2011 04:00:00 +0100 5346378 http://www.medworm.com/index.php?rid=5346377&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21996264%26dopt%3DAbstract CONCLUSION: While 17β-estradiol increases the invasion and proliferation of ovarian cancer cells, these effects do not translate into increased tumor burden in a genetic mouse model of endometrioid ovarian cancer. Likewise, while the SERM reversed the detrimental effects of estrogen in vitro, there was no change in tumor burden in mice treated with bazedoxifene. These findings demonstrate the complex interplay between hormones and ovarian carcinogenesis. PMID: 21996264 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5346377 Tue, 11 Oct 2011 04:00:00 +0100 5346377 http://www.medworm.com/index.php?rid=5346382&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21992967%26dopt%3DAbstract CONCLUSION: PE is a therapeutic option in advanced primary or relapsed vulvar carcinoma, offering median- to long-term survival for many patients. Carcinomatous spread to regional lymph nodes and complete resection are the most important prognostic factors. PMID: 21992967 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5346382 Mon, 10 Oct 2011 04:00:00 +0100 5346382 http://www.medworm.com/index.php?rid=5346384&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21982046%26dopt%3DAbstract CONCLUSIONS: Patients receiving adjuvant IP chemotherapy are less likely to first recur in the lower abdomen or pelvis and more likely to recur outside of the abdominal cavity. The data suggest that IP chemotherapy is highly effective in the anatomic areas of peritoneal distribution. PMID: 21982046 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5346384 Fri, 07 Oct 2011 04:00:00 +0100 5346384 http://www.medworm.com/index.php?rid=5346386&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21982044%26dopt%3DAbstract CONCLUSIONS: B7-H3 is overexpressed on cancer cells and in the endothelium of tumor-associated vasculature in high grade tumors (G3) and type II carcinomas. B7-H3 expression on cancer cells is correlated with the number of T cells infiltrating the tumor. Endometrium tumor development and progression may be associated with downregulation of T-cell-mediated antitumor immunity through B7-H3. PMID: 21982044 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5346386 Thu, 06 Oct 2011 04:00:00 +0100 5346386 http://www.medworm.com/index.php?rid=5346385&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21982045%26dopt%3DAbstract "Kegel ball" induced vaginal cuff dehiscence following radical abdominal hysterectomy: Laparoscopically-assisted transvaginal retrieval. Gynecol Oncol. 2011 Oct 6; Authors: Bristow RE PMID: 21982045 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5346385 Thu, 06 Oct 2011 04:00:00 +0100 5346385 http://www.medworm.com/index.php?rid=5346383&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21982047%26dopt%3DAbstract CONCLUSIONS: The incidence of lymph node metastases in clinical early stage EOC is considerable. Based on the scarce literature data, omitting a systematic lymphadenectomy can only be considered in grade I mucinous tumors. PMID: 21982047 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5346383 Thu, 06 Oct 2011 04:00:00 +0100 5346383 http://www.medworm.com/index.php?rid=5346387&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21978765%26dopt%3DAbstract CONCLUSIONS: GC does not improve PFS over TC as first-line induction chemotherapy in OC. Although favoring TC, overall survival analyses were limited by the study design and high censoring rates. PMID: 21978765 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5346387 Tue, 04 Oct 2011 04:00:00 +0100 5346387 http://www.medworm.com/index.php?rid=5346390&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21968340%26dopt%3DAbstract CONCLUSION: While perineural invasion was found to be associated with multiple high-risk factors, it was not found to be associated with a worse prognosis in early cervical cancer. PMID: 21968340 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5346390 Sat, 01 Oct 2011 04:00:00 +0100 5346390 http://www.medworm.com/index.php?rid=5346389&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21968341%26dopt%3DAbstract CONCLUSION: Endometrial cancer patients who have robotic surgery experience less initial postoperative pain and have fewer drug interventions. The cost associated for their pain management represents a savings of greater than 50%. These factors demonstrate the value of robotic surgery in regard to postoperative pain management by delivering higher quality care at a lower cost. PMID: 21968341 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5346389 Sat, 01 Oct 2011 04:00:00 +0100 5346389 http://www.medworm.com/index.php?rid=5346388&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21968342%26dopt%3DAbstract CONCLUSION: Most patients underestimate their risk of LS associated heritable cancer. Physicians should pay more attention to family history and IHC in order to refer patients appropriately. In addition, more verbal and written information may enable patients to accurately assess their cancer risk. This could further improve compliance with genetic counseling and detection of Lynch syndrome. PMID: 21968342 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5346388 Sat, 01 Oct 2011 04:00:00 +0100 5346388 http://www.medworm.com/index.php?rid=5282454&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21962933%26dopt%3DAbstract Authors: Park JY, Nam JH PMID: 21962933 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5282454 Fri, 30 Sep 2011 04:00:00 +0100 5282454 http://www.medworm.com/index.php?rid=5282453&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21963091%26dopt%3DAbstract CONCLUSION: Uterine papillary serous cancer can be an aggressive tumor type with a poor prognosis. RFS was improved by radiation and chemotherapy with few grade 3 or higher complications. Using radiation and paclitaxel-platinum chemotherapy should be attempted whenever feasible for patients with UPSC who do not have distant metastases at diagnosis. PMID: 21963091 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5282453 Fri, 30 Sep 2011 04:00:00 +0100 5282453 http://www.medworm.com/index.php?rid=5282452&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21963092%26dopt%3DAbstract CONCLUSIONS: Residence and location of treatment center are not an important factor in cervical cancer survival when a tertiary cancer center can oversee and coordinate care; however, comorbid risk factors influence survival and further exploration of disease comorbidity related to cervical cancer survival is warranted. PMID: 21963092 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5282452 Fri, 30 Sep 2011 04:00:00 +0100 5282452 http://www.medworm.com/index.php?rid=5282455&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21958535%26dopt%3DAbstract CONCLUSION: The morbidity of cytoreduction is greatest in elderly women where the effects of age and the number of radical procedures performed have an additive effect on complication rates. PMID: 21958535 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5282455 Tue, 27 Sep 2011 04:00:00 +0100 5282455 http://www.medworm.com/index.php?rid=5282460&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21955480%26dopt%3DAbstract CONCLUSIONS: The combination of sorafenib and topotecan causes significant toxicity, precluding administration of full doses and resulting in modest clinical efficacy in platinum resistant OC or PPC. PMID: 21955480 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5282460 Mon, 26 Sep 2011 04:00:00 +0100 5282460 http://www.medworm.com/index.php?rid=5282459&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21955481%26dopt%3DAbstract Re: "The impact of tumor morcellation during surgery on the prognosis of patients with apparently early uterine leiomyosarcoma" Gynecol Oncol. 2011 Sep 26; Authors: Leung F, Terzibachian JJ PMID: 21955481 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5282459 Mon, 26 Sep 2011 04:00:00 +0100 5282459 http://www.medworm.com/index.php?rid=5282458&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21955482%26dopt%3DAbstract CONCLUSIONS: This novel assay provides a real-time PCR-based method for absolute quantitation of DNA methylation. Our results support feasibility of monitoring RASSF1A methylation from serum samples taken over the course of treatment from women with ovarian cancer. PMID: 21955482 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5282458 Mon, 26 Sep 2011 04:00:00 +0100 5282458 http://www.medworm.com/index.php?rid=5282457&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21955483%26dopt%3DAbstract CONCLUSION: Concurrent weekly carboplatin with radiation therapy yields high response rate with modest progression-free and overall survivals in locally advanced cervical cancer. The regimen is feasible with minimal toxicities. PMID: 21955483 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5282457 Mon, 26 Sep 2011 04:00:00 +0100 5282457 http://www.medworm.com/index.php?rid=5282456&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21955484%26dopt%3DAbstract CONCLUSION: This study suggests that CCC patients other than those with intraoperative capsule rupture show a considerable risk for mortality despite adjuvant chemotherapy. PMID: 21955484 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5282456 Mon, 26 Sep 2011 04:00:00 +0100 5282456 http://www.medworm.com/index.php?rid=5282468&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21945307%26dopt%3DAbstract Authors: Höckel M, Horn LC PMID: 21945307 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5282468 Sat, 24 Sep 2011 04:00:00 +0100 5282468 http://www.medworm.com/index.php?rid=5282467&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21945308%26dopt%3DAbstract CONCLUSIONS: Taken together, these data suggest that costunolide, alone or in combination with cisplatin, may be of therapeutic potential in platinum-resistant ovarian cancer. PMID: 21945308 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5282467 Sat, 24 Sep 2011 04:00:00 +0100 5282467 http://www.medworm.com/index.php?rid=5282466&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21945309%26dopt%3DAbstract CONCLUSIONS: NAC followed by surgery was associated with fewer surgical complications than PDS. The direction and magnitude of the difference in survival between women receiving NAC and those receiving PDS differed according to the stage of disease and follow up time. PMID: 21945309 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5282466 Sat, 24 Sep 2011 04:00:00 +0100 5282466 http://www.medworm.com/index.php?rid=5282465&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21945310%26dopt%3DAbstract CONCLUSIONS: Sequential single agent docetaxel followed by carboplatin is associated with improved HRQL when compared to cDC. The improved progression-free survival observed with cDC should be weighed against lower quality of life during treatment. PMID: 21945310 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5282465 Sat, 24 Sep 2011 04:00:00 +0100 5282465 http://www.medworm.com/index.php?rid=5282464&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21945551%26dopt%3DAbstract CONCLUSIONS: Cytoreductive surgery, with a goal of achieving a complete gross resection, is associated with an improvement in OS among patients with advanced uterine CS. PMID: 21945551 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5282464 Fri, 23 Sep 2011 04:00:00 +0100 5282464 http://www.medworm.com/index.php?rid=5282463&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21945552%26dopt%3DAbstract CONCLUSIONS: Women with BRCA-associated ovarian tumors demonstrate a greater sensitivity to cytotoxic therapy with Doxil than has previously been reported in unselected cases. PMID: 21945552 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5282463 Fri, 23 Sep 2011 04:00:00 +0100 5282463 http://www.medworm.com/index.php?rid=5282462&cid=s_35590_6_f&fid=35590&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21945553%26dopt%3DAbstract CONCLUSIONS: Although SLN biopsy has shown good diagnostic performance in endometrial cancer, such performance should be interpreted with caution because of significant small study effects. Current evidence is not yet sufficient to establish the true performance of SLN biopsy in endometrial cancer. PMID: 21945553 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology) Gynecologic Oncology journals http://www.medworm.com/rss/comments.php?id=5282462 Fri, 23 Sep 2011 04:00:00 +0100 5282462