HIV Medicine via MedWorm.com MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'HIV Medicine' source. Wed, 08 Feb 2012 18:15:42 +0100 Room for manoeuvre when prescribing statins to dyslipidaemic patients on antiretroviral therapy http://www.medworm.com/index.php?rid=5649380&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00957.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5649380 Thu, 02 Feb 2012 22:45:47 +0100 5649380 Low free testosterone in HIV‐infected men is not associated with subclinical cardiovascular disease http://www.medworm.com/index.php?rid=5649376&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00988.x ConclusionsCompared with HIV‐uninfected men, HIV‐infected men had lower FT, as well as more prevalent carotid lesions. In both groups, FT was not associated with CAC presence, log carotid IMT, or carotid lesion presence, suggesting that FT does not influence subclinical CVD in this population of men with and at risk for HIV infection. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5649376 Thu, 02 Feb 2012 22:44:50 +0100 5649376 Earlier initiation of antiretroviral therapy, increased tuberculosis case finding and reduced mortality in a setting of improved HIV care: a retrospective cohort study http://www.medworm.com/index.php?rid=5649379&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00980.x ConclusionsBaseline CD4 cell counts have increased over time and are associated with decreased mortality. Additional reductions in mortality might be a result of a better standard of care and increased TB case finding. Further efforts to initiate ART earlier should be prioritized even in a setting of capped or reduced funding for ART programmes. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5649379 Thu, 02 Feb 2012 05:00:00 +0100 5649379 Guidance on vaccination of HIV‐infected children in Europe http://www.medworm.com/index.php?rid=5649378&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00982.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5649378 Thu, 02 Feb 2012 05:00:00 +0100 5649378 Improved serological response to H1N1 monovalent vaccine associated with viral suppression among HIV‐1‐infected patients during the 2009 influenza (H1N1) pandemic in the Southern Hemisphere http://www.medworm.com/index.php?rid=5649377&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00987.x ConclusionsA high prevalence of HI H1N1 antibodies was found before vaccination in the cohort, consistent with previous exposure to H1N1 influenza virus. The response to vaccination was considered adequate, as more than two‐thirds of patients achieved a fourfold or more increase in antibody titre after vaccination. The response to vaccination was significantly greater in those patients who were aviraemic for HIV, suggesting that antiretroviral therapy improves the humoral response, which is important in optimizing vaccine effectiveness. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5649377 Thu, 02 Feb 2012 05:00:00 +0100 5649377 Predictive value of HIV‐1 replication capacity and phenotypic susceptibility scores in antiretroviral treatment‐experienced patients http://www.medworm.com/index.php?rid=5629966&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00981.x ConclusionsWe found no additional predictive value of replication capacity for virological or immunological responses (above what PSS provides) in patients undergoing salvage ARV treatment. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5629966 Thu, 26 Jan 2012 23:01:57 +0100 5629966 Effect of the HIV nucleoside reverse transcriptase inhibitor zidovudine on the growth and differentiation of primary gingival epithelium http://www.medworm.com/index.php?rid=5629968&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00973.x ConclusionsZidovudine treatment, even when applied at low concentrations for short periods of time, deregulated the cell cycle/proliferation and differentiation pathways, resulting in abnormal epithelial repair and proliferation. Our system could potentially be developed as a model for studying the effects of HIV and highly active antiretroviral therapy in vitro. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5629968 Thu, 26 Jan 2012 05:00:00 +0100 5629968 Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV‐1 reservoirs: results from a multicentre randomized clinical study http://www.medworm.com/index.php?rid=5629967&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00975.x ConclusionsOur study demonstrates that adding VPA to stable HAART does not reduce the latent HIV reservoir in virally suppressed patients. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5629967 Thu, 26 Jan 2012 05:00:00 +0100 5629967 Methicillin‐resistant Staphylococcus aureus (MRSA) infections among HIV‐infected persons in the era of highly active antiretroviral therapy: a review of the literature http://www.medworm.com/index.php?rid=5629971&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00978.x ConclusionsHIV‐infected persons have a propensity for MRSA SSTI and a high rate of recurrent disease. The reasons for the elevated rates of MRSA infections among HIV‐infected persons appear to be multifactorial, but may be mitigated with optimized HIV control and reductions in associated risk factors. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5629971 Wed, 25 Jan 2012 05:00:00 +0100 5629971 Nonoccupational post‐exposure prophylaxis source tracing: is it really feasible in Australia? http://www.medworm.com/index.php?rid=5629970&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00986.x ConclusionWe hypothesize that there are a number of differences between Australia and Switzerland that make source tracing unfeasible in Australia. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5629970 Wed, 25 Jan 2012 05:00:00 +0100 5629970 Safe travels? HIV transmission among Britons travelling abroad http://www.medworm.com/index.php?rid=5629969&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00983.x ConclusionsA substantial number of UK‐born adults are acquiring HIV infection in countries with generalized HIV epidemics, and in common holiday destinations. Of particular concern is the high proportion of men infected reporting sex with a commercial sex worker. We recommend HIV prevention and testing efforts be extended to include travellers abroad, and that sexual health advice be provided routinely in travel health consultations and in occupational health travel advice packs, particularly to those travelling to high HIV prevalence areas and destinations for sex tourism. Safer sex messages should include an awareness of the potential detrimental health and social impacts of the sex industry. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5629969 Wed, 25 Jan 2012 05:00:00 +0100 5629969 Association of HIV viral load and CD4 cell count with human papillomavirus detection and clearance in HIV‐infected women initiating highly active antiretroviral therapy http://www.medworm.com/index.php?rid=5610194&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00979.x ConclusionsHigh‐risk HPV types vary among studies and can affect the results of analyses. Use of HAART to improve CD4 cell count may have an impact on the control of HPV infection. The decrease in VL may also have an effect, although to a lesser degree. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5610194 Fri, 20 Jan 2012 22:35:55 +0100 5610194 Zinc alpha‐2 glycoprotein is implicated in dyslipidaemia in HIV‐1‐infected patients treated with antiretroviral drugs http://www.medworm.com/index.php?rid=5610195&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00976.x ConclusionsHIV‐1‐infected patients have lower plasma ZAG levels than uninfected controls. In infected patients, plasma ZAG levels are in close relationship with total cholesterol and HDLc. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5610195 Thu, 19 Jan 2012 05:00:00 +0100 5610195 The rate of HIV testing is increasing among men who have sex with men in China http://www.medworm.com/index.php?rid=5610199&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00974.x ConclusionsChinese MSM have relatively low HIV testing rates compared with MSM in other settings. It is important to continue to promote HIV testing among MSM in China. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5610199 Wed, 18 Jan 2012 05:00:00 +0100 5610199 Antiretroviral therapy prescribing in hospitalized HIV clinic patients http://www.medworm.com/index.php?rid=5610198&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00977.x ConclusionHospital HIV medication management still remains an area of focus because of the complexity of regimens, poor medication reconciliation and limited non‐HIV/ID specialist knowledge. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5610198 Wed, 18 Jan 2012 05:00:00 +0100 5610198 Outcome of smoking cessation counselling of HIV‐positive persons by HIV care physicians http://www.medworm.com/index.php?rid=5610197&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00984.x ConclusionsAn institution‐wide training programme for HIV care physicians in smoking cessation counselling led to increased smoking cessation and fewer relapses. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5610197 Wed, 18 Jan 2012 05:00:00 +0100 5610197 HIV, HEV and cirrhosis: evidence of a possible link from eastern Spain http://www.medworm.com/index.php?rid=5610196&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00985.x ConclusionsOur findings show a high prevalence of anti‐HEV in HIV‐infected patients, strongly associated with liver cirrhosis. Chronic HEV infection was detected in a significant number of HEV‐seropositive patients. Further research is needed to ascertain whether cirrhosis is a predisposing factor for HEV infection and to assess the role of chronic HEV infection in the pathogeneses of cirrhosis in this population. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5610196 Wed, 18 Jan 2012 05:00:00 +0100 5610196 British HIV Association guidelines for the routine investigation and monitoring of adult HIV‐1‐infected individuals 2011 http://www.medworm.com/index.php?rid=5506187&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00971.x Table of Contents1. Levels of evidence1.1 Reference2. Introduction3. Auditable targets4. Table summaries4.1 Initial diagnosis4.2 Assessment of ART‐naïve individuals4.3 ART initiation4.4 Initial assessment following commencement of ART4.5 Routine monitoring on ART4.6 References5. Newly diagnosed and transferring HIV‐positive individuals5.1 Initial HIV‐1 diagnosis5.2 Tests to determine whether acquisition of HIV infection is recent5.3 Individuals transferring care from a different HIV healthcare setting5.4 Communication with general practitioners and shared care5.5 Recommendations5.6 References6. Patient history6.1 Initial HIV‐1 diagnosis6.2 Monitoring of ART‐naïve patients6.3 Pre‐ART initiation assessment6.4 Monitoring individuals ... HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5506187 Fri, 16 Dec 2011 11:07:07 +0100 5506187 Dynamics of cognitive change in HIV‐infected individuals commencing three different initial antiretroviral regimens: a randomized, controlled study http://www.medworm.com/index.php?rid=5495590&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00962.x ConclusionImprovements in NC function continue over the first year after initiating antiretroviral therapy in neuro‐asymptomatic HIV‐infected subjects. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5495590 Mon, 12 Dec 2011 05:00:00 +0100 5495590 Population mobility and the changing epidemics of HIV‐2 in Portugal http://www.medworm.com/index.php?rid=5477477&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00963.x ConclusionHIV‐2 infection has been documented in Portugal since the early 1980s and its epidemiology appears to reflect changes in population movement. These include the movements of soldiers and repatriates from African territories during the independence wars and, later, migration and mobility from high‐endemicity areas. The findings of this study stress the importance of promoting migrant‐sensitive health care. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5477477 Sun, 04 Dec 2011 05:00:00 +0100 5477477 Pregnancy outcomes in adolescents in the UK and Ireland growing up with HIV http://www.medworm.com/index.php?rid=5477476&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00967.x ConclusionsDespite access to ongoing sexual health and contraceptive services, unplanned pregnancies are occurring in young women growing up with HIV. Pregnancy care and prevention of onward transmission require complex case management for this emerging population. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5477476 Sun, 04 Dec 2011 05:00:00 +0100 5477476 Twenty‐four‐week efficacy and safety of switching virologically suppressed HIV‐1‐infected patients from nevirapine immediate release 200 mg twice daily to nevirapine extended release 400 mg once daily (TRANxITION) http://www.medworm.com/index.php?rid=5477475&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00969.x ConclusionsNVP XR administered once daily resulted in continued virological suppression at week 24 that was noninferior to that provided by NVP IR, with similar rates of moderate and severe AEs. The higher frequency of overall AEs with NVP XR may be a consequence of the open‐label design. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5477475 Sun, 04 Dec 2011 05:00:00 +0100 5477475 Participation, characteristics and retention rates of HIV‐positive immigrants in the Swiss HIV Cohort Study* http://www.medworm.com/index.php?rid=5442259&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00949.x ConclusionsNumbers of HIV‐infected immigrants are increasing but they are underrepresented in the SHCS, and immigrants are more likely to be lost to follow‐up. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5442259 Tue, 22 Nov 2011 05:00:00 +0100 5442259 Treatment limitations imposed by antiretroviral drug resistance mutations: implication for choices of first line regimens in resource‐limited settings http://www.medworm.com/index.php?rid=5442258&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00950.x ConclusionThe use of NNRTI‐based first‐line ART regimens may limit the options for second‐line treatment when the number of available drugs is limited. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5442258 Tue, 22 Nov 2011 05:00:00 +0100 5442258 High acceptability of HIV voluntary counselling and testing among female sex workers: impact of individual and social factors http://www.medworm.com/index.php?rid=5442257&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00951.x ConclusionAcceptability of VCT appears high in the FSW population in Conakry as a consequence of both perceptions of high individual risk and social pressures. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5442257 Tue, 22 Nov 2011 05:00:00 +0100 5442257 Pharmacokinetics of the nonnucleoside reverse transcriptase inhibitor efavirenz among HIV‐infected Ugandans http://www.medworm.com/index.php?rid=5442256&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00952.x Conclusion The findings of this study show that HIV‐infected patients on efavirenz may exhibit autoinduction to various extents, and this needs to be taken into consideration in the clinical management of individual patients. Efavirenz CNS toxicity during the initial phase of treatment may be related to Cmax, regardless of the sampling time. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5442256 Tue, 22 Nov 2011 05:00:00 +0100 5442256 Efficacy of new antiretroviral drugs in treatment‐experienced HIV‐infected patients: a systematic review and meta‐analysis of recent randomized controlled trials http://www.medworm.com/index.php?rid=5442255&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00953.x ConclusionsOur study confirmed the overall immunological and virological efficacy of new antiretroviral drugs in treatment‐experienced patients, compared with placebo. The main predictive factor for efficacy was the number of fully active drugs. CCR5 inhibitors did not increase CD4 cell count to a greater extent than other new drugs. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5442255 Tue, 22 Nov 2011 05:00:00 +0100 5442255 Non‐uptake of highly active antiretroviral therapy among patients with a CD4 count http://www.medworm.com/index.php?rid=5442254&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00956.x ConclusionA substantial minority of patients with a CD4 count < 350 cells/μL remain untreated despite its indication. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5442254 Tue, 22 Nov 2011 05:00:00 +0100 5442254 Effects of in utero antiretroviral exposure on mitochondrial DNA levels, mitochondrial function and oxidative stress http://www.medworm.com/index.php?rid=5432498&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00945.x ConclusionsHIV‐exposed infants showed reduced umbilical cord blood mitochondrial enzyme expression with increased infant peripheral blood mitochondrial DNA levels, the latter possibly reflecting a compensatory mechanism to overcome HIV/ART‐associated mitochondrial toxicity. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5432498 Mon, 21 Nov 2011 05:00:00 +0100 5432498 Incentivized recruitment of a population sample to a mobile HIV testing service increases the yield of newly diagnosed cases, including those in need of antiretroviral therapy http://www.medworm.com/index.php?rid=5432497&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00947.x ConclusionCompared with routine voluntary HCT, selection and invitation in combination with incentives doubled the yield of newly diagnosed HIV infections and increased the yield almost fourfold of individuals needing antiretroviral therapy. This may be an important strategy to increase community‐based HIV diagnosis and access to care. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5432497 Mon, 21 Nov 2011 05:00:00 +0100 5432497 Late presentation for HIV diagnosis and care in Germany http://www.medworm.com/index.php?rid=5388962&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00958.x ConclusionsIn Germany, the numbers of late presenters for HIV diagnosis and care remain high. The probability of late presentation for HIV diagnosis seems to be particularly high for migrants. These results argue in favour of targeted test promotion rather than opt‐out screening. Late presentation for care seems to be an additional problem after HIV diagnosis. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5388962 Mon, 07 Nov 2011 05:00:00 +0100 5388962 Late presentation of HIV infection among adults in New Zealand: 2005–2010 http://www.medworm.com/index.php?rid=5388964&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00959.x ConclusionsThe high proportion of people presenting late reflects inadequate levels of HIV testing. The lower proportion of late presentations among MSM compared with those heterosexually infected may be explained by a higher proportion of recent locally acquired infections together with different testing patterns. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5388964 Thu, 03 Nov 2011 04:00:00 +0100 5388964 Emergence of an HIV‐1 cluster harbouring the major protease L90M mutation among treatment‐naïve patients in Tel Aviv, Israel http://www.medworm.com/index.php?rid=5388963&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00960.x ConclusionThere was an unexpectedly high rate of the major L90MPI resistance mutation in the MSM group. The clustered transmission of this mutation might be related to a high‐risk sexual behaviour. Added to nonnucleoside reverse transcriptase inhibitor and nucleoside reverse transcriptase inhibitor resistance mutations, such a PI mutation may limit future therapeutic options for this particular patient population. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5388963 Thu, 03 Nov 2011 04:00:00 +0100 5388963 Evaluating the extent of potential resistance to pre‐exposure prophylaxis within the UK HIV‐1‐infectious population of men who have sex with men http://www.medworm.com/index.php?rid=5495589&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00968.x ConclusionsOur analysis indicates low levels of resistance to proposed PrEP drugs. The estimated PrEP resistance prevalence in UK HIV‐infected MSM is towards the lower range of values used in simulation studies which have suggested that circulating PrEP drug resistance will have a negligible impact on PrEP efficacy at the population level. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5495589 Tue, 01 Nov 2011 04:00:00 +0100 5495589 Metabolic abnormalities and viral replication are associated with biomarkers of vascular dysfunction in HIV‐infected children http://www.medworm.com/index.php?rid=5477474&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00970.x ConclusionsHIV‐infected children have higher levels of biomarkers of vascular dysfunction than do HEU children. Risk factors associated with higher biomarkers include unfavourable lipid levels and active HIV replication. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5477474 Tue, 01 Nov 2011 04:00:00 +0100 5477474 Effect of pregnancy on emtricitabine pharmacokinetics http://www.medworm.com/index.php?rid=5458986&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00965.x ConclusionsWhile we found higher emtricitabine CL/F and lower C24 and AUC during pregnancy compared with postpartum, these changes were not sufficiently large to warrant dose adjustment during pregnancy. Umbilical cord blood concentrations were similar to maternal concentrations. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5458986 Tue, 01 Nov 2011 04:00:00 +0100 5458986 Clinical outcomes of HIV‐infected patients with Kaposi's sarcoma receiving nonnucleoside reverse transcriptase inhibitor‐based antiretroviral therapy in Uganda http://www.medworm.com/index.php?rid=5442253&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00955.x ConclusionPrevalent or incident KS was associated with 30% mortality. The resolution of KS lesions among individuals who initiated HAART with NNRTI‐based regimens was similar to that found in studies using only protease inhibitor‐based HAART. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5442253 Tue, 01 Nov 2011 04:00:00 +0100 5442253 High prevalence of unintended pregnancies in HIV‐positive women of reproductive age in Ontario, Canada: a retrospective study http://www.medworm.com/index.php?rid=5432496&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00946.x ConclusionsThe prevalence of unintended pregnancy was high in this cohort. Pregnancy planning programmes are needed for this population to decrease fetal and maternal complications and reduce vertical and horizontal transmission. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5432496 Tue, 01 Nov 2011 04:00:00 +0100 5432496 Testing children of mothers with HIV infection: experience in three south‐west London HIV clinics http://www.medworm.com/index.php?rid=5409719&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00948.x ConclusionsA significant number of children at risk of vertically transmitted HIV infection, including 49 children ≤18 years and resident in the UK, were identified through this study. The mothers are being encouraged to have these children tested and a multidisciplinary team involving adult and paediatric HIV healthcare professionals has been set up to negotiate and facilitate testing. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5409719 Tue, 01 Nov 2011 04:00:00 +0100 5409719 Strong serological responses and HIV RNA increase following AS03‐adjuvanted pandemic immunization in HIV‐infected patients http://www.medworm.com/index.php?rid=5388961&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00961.x ConclusionMost HIV‐infected patients developed seroprotection after two doses of AS03‐adjuvanted pandemic vaccine. A transient effect on HIV RNA levels was observed in previously aviraemic patients. A booster dose of the nonadjuvanted influenza vaccine containing the A/09/H1N1 strain the following year did not reproduce this finding, indicating a non‐antigen‐specific adjuvant effect. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5388961 Tue, 01 Nov 2011 04:00:00 +0100 5388961 A note of thanks to referees for Volume 12, 2011 http://www.medworm.com/index.php?rid=5337359&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00972.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5337359 Sat, 22 Oct 2011 23:52:54 +0100 5337359 HIV antiretroviral therapy reduces circulating surfactant protein‐D levels http://www.medworm.com/index.php?rid=5261914&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00920.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5261914 Thu, 29 Sep 2011 11:37:02 +0100 5261914 British HIV Association guidelines for the treatment of TB/HIV coinfection 2011 http://www.medworm.com/index.php?rid=5261913&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00954.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5261913 Thu, 29 Sep 2011 11:36:50 +0100 5261913 The rate of accumulation of nonnucleoside reverse transcriptase inhibitor (NNRTI) resistance in patients kept on a virologically failing regimen containing an NNRTI* http://www.medworm.com/index.php?rid=5145087&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00943.x ConclusionsThere is an initial phase of rapid accumulation of NNRTI mutations close to the time of VF followed by a phase of slower accumulation. We predict that it should take approximately one year of exposure to a virologically failing first‐generation NNRTI‐based cART regimen to reduce etravirine activity from fully susceptible to intermediate resistant, and possibly longer in patients kept on a failing nevirapine‐containing regimen. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5145087 Sat, 20 Aug 2011 17:11:03 +0100 5145087 Decision‐making by people living with HIV requires communication from clinicians about the risks of transmission despite undetectable plasma viral load http://www.medworm.com/index.php?rid=5120607&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00909.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5120607 Fri, 12 Aug 2011 19:19:03 +0100 5120607 Major but differential decline in the incidence of Staphylococcus aureus bacteraemia in HIV‐infected individuals from 1995 to 2007: a nationwide cohort study* http://www.medworm.com/index.php?rid=5110644&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00937.x ConclusionsWe found that the incidence of SAB among HIV‐infected individuals declined during the study period, but remained higher than that among HIV‐uninfected individuals. There was an unevenly distributed burden of SAB among HIV transmission groups (IDU>MSM). Low CD4 cell count and IDU were strong predictors of SAB among HIV‐infected individuals. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5110644 Sat, 06 Aug 2011 23:00:00 +0100 5110644 Does use of antiretroviral therapy regimens with high central nervous system penetration improve survival in HIV‐infected adults? http://www.medworm.com/index.php?rid=5110643&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00938.x Conclusions Our findings do not show a significant overall survival benefit associated with neurocART compared with cART. The potential benefit associated with neurocART in terms of prevention of neurocognitive impairment did not translate into an improvement in overall survival in this population. These findings were limited by the low incidence of associated mortality. Further studies and more extensive data are needed to address these limitations. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5110643 Sat, 06 Aug 2011 23:00:00 +0100 5110643 Cervical intraepithelial neoplasia and invasive cancer risks in women infected with HIV in the French West Indies http://www.medworm.com/index.php?rid=5110642&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00939.x Conclusions Despite an increase in the occurrence of cervical cancer precursors, no increase in the risk of cervical cancer was found in a population of HIV‐infected women who receive treatment for their infection and have access to ICC prevention services. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5110642 Sat, 06 Aug 2011 23:00:00 +0100 5110642 The effect of injecting drug use history on disease progression and death among HIV‐positive individuals initiating combination antiretroviral therapy: collaborative cohort analysis http://www.medworm.com/index.php?rid=5110641&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00940.x Conclusion While liver‐related deaths and deaths from direct effects of substance abuse appear to explain much of the excess mortality in IDUs, they are at increased risk for many other causes of death, which may relate to suboptimal management of HIV disease in these individuals. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5110641 Sat, 06 Aug 2011 23:00:00 +0100 5110641 Randomized comparison of metabolic and renal effects of saquinavir/r or atazanavir/r plus tenofovir/emtricitabine in treatment‐naïve HIV‐1‐infected patients http://www.medworm.com/index.php?rid=5110640&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00941.x Conclusions Combined with TDF/FTC, both SQV/r 2000/100 mg and ATV/r 300/100 mg had comparable modest effects on lipids, had little effect on glucose metabolism, conserved adipose tissue, and similarly reduced eGFR. The virological efficacy was similar. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5110640 Sat, 06 Aug 2011 23:00:00 +0100 5110640 Hepatitis E virus coinfection in patients with HIV infection http://www.medworm.com/index.php?rid=5110639&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00942.x Conclusions Anti‐HEV seroprevalence is similar in controls and patients with HIV infection. Risk factor analysis suggests that HEV is unlikely to be transmitted sexually. Chronic coinfection with HEV was absent, indicating that chronic HEV/HIV coinfection is not a common problem in this cohort. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5110639 Sun, 31 Jul 2011 23:00:00 +0100 5110639 Authors' response to Drs Scourfield, Jackson and Nelson http://www.medworm.com/index.php?rid=5000104&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00932.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5000104 Wed, 06 Jul 2011 16:04:42 +0100 5000104 Will earlier diagnosis of HIV infection in late presenters reduce the frequency of serious opportunistic infections? http://www.medworm.com/index.php?rid=5000103&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00931.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5000103 Wed, 06 Jul 2011 16:04:41 +0100 5000103 Immunization status of children with HIV: failure to protect a vulnerable population http://www.medworm.com/index.php?rid=5000102&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00895.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5000102 Wed, 06 Jul 2011 16:04:41 +0100 5000102 Clinical relevance of cytomegalovirus viraemia*,† http://www.medworm.com/index.php?rid=5000101&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00900.x ConclusionQuantitative CMV DNA detected in the plasma of HIV‐infected patients with CD4 counts ≤100 cells/μL is a predictor for HIV disease progression, CMV disease and death. A single low value of 80 copies/mL identifies patients at low but significantly increased risk during the following months, after the measurement. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5000101 Wed, 06 Jul 2011 16:04:33 +0100 5000101 Cytomegalovirus viraemia in the modern antiretroviral era* http://www.medworm.com/index.php?rid=5000100&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00899.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5000100 Wed, 06 Jul 2011 16:04:30 +0100 5000100 Impaired antibody memory to varicella zoster virus in HIV‐infected children: low antibody levels and avidity* http://www.medworm.com/index.php?rid=5000092&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00936.x Conclusion Failure to maintain anti‐VZV IgG levels in HIV‐infected children results from failure to reactivate memory responses. Further studies are required to investigate long‐term protection and the potential benefits of immunization. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=5000092 Wed, 06 Jul 2011 16:03:41 +0100 5000092 Acute systemic inflammation induced by influenza A (H1N1) vaccination causes a deterioration in endothelial function in HIV‐infected patients http://www.medworm.com/index.php?rid=4904963&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00935.x ConclusionsAcute systemic inflammation induced by vaccination against the influenza A/H1N1 virus resulted in a deterioration in endothelial function in HIV‐infected patients, and this effect was sustained for at least 48 h. Our findings may have important implications in view of the high cardiovascular risk that HIV infection carries. The effect of the novel vaccine on endothelial function should be weighed against the immunological protection that it confers. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4904963 Tue, 07 Jun 2011 17:39:25 +0100 4904963 Paediatric European Network for Treatment of AIDS response to 2010 revision of World Health Organization recommendations on ‘Antiretroviral therapy for HIV infection in infants and children’ http://www.medworm.com/index.php?rid=4886344&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00914.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4886344 Thu, 02 Jun 2011 16:57:03 +0100 4886344 Reduced delays in time to first HIV consultation after diagnosis in France in the antiretroviral therapy era: the possible role of a free care system http://www.medworm.com/index.php?rid=4886343&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00893.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4886343 Thu, 02 Jun 2011 16:57:03 +0100 4886343 Safety and efficacy of raltegravir in patients with HIV‐1 and hepatitis B and/or C virus coinfection http://www.medworm.com/index.php?rid=4855021&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00933.x Conclusion Raltegravir was generally well tolerated and efficacious up to 96 weeks in HIV‐infected patients with HBV/HCV coinfection. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4855021 Sat, 21 May 2011 23:00:00 +0100 4855021 Safety and exposure of once‐daily ritonavir‐boosted atazanavir in HIV‐infected pregnant women http://www.medworm.com/index.php?rid=4832749&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00927.x Conclusions In this study, use of atazanavir/RTV 300/100 mg qd produced Cmin comparable to historical data in nonpregnant HIV‐infected adults. When used in combination with zidovudine/lamivudine, it suppressed HIV RNA in all mothers and prevented mother‐to‐child transmission of HIV‐1 infection. During pregnancy, the pharmacokinetics, safety and efficacy demonstrated that a dose adjustment is not required for ATV. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4832749 Sun, 15 May 2011 23:00:00 +0100 4832749 Long‐term trends in CD4 cell counts and impact of viral failure in individuals starting antiretroviral therapy: UK Collaborative HIV Cohort (CHIC) study http://www.medworm.com/index.php?rid=4832748&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00929.x ConclusionsPost‐cART CD4 cell counts are strongly related to pre‐cART CD4 cell counts. CD4 cell count recovery is greatest in individuals who can avoid viral loads >1000 copies/mL while on cART. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4832748 Sun, 15 May 2011 23:00:00 +0100 4832748 Hyperlactataemia in HIV‐infected subjects initiating antiretroviral therapy in a large randomized study (a substudy of the INITIO trial) http://www.medworm.com/index.php?rid=4855020&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00934.x Conclusion The development of LA/SHL was associated with increased BMI, but PBMC mtDNA and mtRNA did not predict LA/SHL. This demonstrates the ineffectiveness of routine measurement of PBMC mtDNA in patients on ddI and d4T as a means of predicting development of LA/SHL. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4855020 Sat, 30 Apr 2011 23:00:00 +0100 4855020 First trimester maternal uterine artery Doppler examination in HIV‐positive women http://www.medworm.com/index.php?rid=4832747&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00930.x Conclusions HIV‐positive women with uncomplicated pregnancies have normal placental perfusion in the first trimester of pregnancy. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4832747 Sat, 30 Apr 2011 23:00:00 +0100 4832747 Adherence to antiretroviral therapy: factors independently associated with reported difficulty taking antiretroviral therapy in a national sample of HIV‐positive Australians http://www.medworm.com/index.php?rid=4806927&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00928.x ConclusionsThirteen previously investigated factors were found to be independently associated with reported difficulty taking ART, reaffirming the dynamic nature of adherence behaviour and the ongoing importance of addressing adherence behaviour in the clinical management of PLWH. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4806927 Sat, 30 Apr 2011 23:00:00 +0100 4806927 Morbidity in HIV‐1‐infected individuals before and after the introduction of antiretroviral therapy: a longitudinal study of a population‐based cohort in Uganda http://www.medworm.com/index.php?rid=4759712&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00923.x ConclusionMorbidity in HIV‐positive participants decreased following the introduction of ART, and this decline was more marked with increasing duration on ART. The benefits of decreased HIV‐related morbidity from ART lend support to urgent efforts to ensure universal access to early diagnosis of HIV infection and to ART, especially in rural Africa. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4759712 Thu, 28 Apr 2011 16:34:41 +0100 4759712 Concordance between HIV‐1 genotypic coreceptor tropism predictions based on plasma RNA and proviral DNA http://www.medworm.com/index.php?rid=4749377&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00922.x ConclusionsGTT produced highly concordant tropism predictions for proviral DNA and plasma RNA. GTT on proviral DNA offers a promising approach for tropism prediction in clinical practice, particularly for the assessment of treated patients with low or suppressed viraemia. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4749377 Tue, 26 Apr 2011 15:12:37 +0100 4749377 Lipid profiles for nevirapine vs. atazanavir/ritonavir, both combined with tenofovir disoproxil fumarate and emtricitabine over 48 weeks, in treatment‐naïve HIV‐1‐infected patients (the ARTEN study) http://www.medworm.com/index.php?rid=4749379&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00917.x ConclusionsIn ARV‐naïve patients with low CR at the outset, NVP showed a potentially less atherogenic lipid profile compared with ATZ/r. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4749379 Sat, 23 Apr 2011 23:00:00 +0100 4749379 Can community health workers improve adherence to highly active antiretroviral therapy in the USA? A review of the literature http://www.medworm.com/index.php?rid=4749378&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00921.x ConclusionsCompared with current standards of care, CHW programmes may offer a practical and cost‐effective alternative to improve HAART adherence, which may lead to reduced HIV viral load and increased CD4 cell counts among HIV‐positive populations in the USA. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4749378 Sat, 23 Apr 2011 23:00:00 +0100 4749378 Incidence of and risk factors for bacteraemia in HIV‐infected adults in the era of highly active antiretroviral therapy http://www.medworm.com/index.php?rid=4628102&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00919.x ConclusionsThe likelihood of bacteraemia has risen slightly in recent years. Patients who are Black or have a history of IDU are at higher risk. Further research is needed to identify reasons for this increase and to evaluate programmes designed to reduce the bacteraemia risk. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4628102 Thu, 24 Mar 2011 17:37:41 +0100 4628102 British HIV Association and Children's HIV Association position statement on infant feeding in the UK 2011 http://www.medworm.com/index.php?rid=4617367&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00918.x To prevent the transmission of HIV infection during the postpartum period, the British HIV Association and Children's HIV Association (BHIVA/CHIVA) continue to recommend the complete avoidance of breast feeding for infants born to HIV‐infected mothers, regardless of maternal disease status, viral load or treatment. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4617367 Tue, 22 Mar 2011 17:57:44 +0100 4617367 Hepatitis C virus (HCV) protease variability and anti‐HCV protease inhibitor resistance in HIV/HCV‐coinfected patients http://www.medworm.com/index.php?rid=4602109&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00913.x Conclusion Our study suggests that the natural prevalence of strains resistant to HCV PIs does not differ between HCV‐monoinfected and HIV/HCV‐coinfected patients. Further studies on larger cohorts are needed to confirm these findings and to evaluate the impact of these mutations in clinical practice. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4602109 Thu, 17 Mar 2011 17:33:52 +0100 4602109 Evaluation of antiretroviral‐related errors and interventions by the clinical pharmacist in hospitalized HIV‐infected patients http://www.medworm.com/index.php?rid=4582018&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00915.x Conclusion Antiretroviral‐related errors affected more than one‐in‐five patients. The most common causes of error were contraindicated or not recommended drug–drug combinations and dose‐related errors. A clinical pharmacist trained in HIV pharmacotherapy could help to detect errors and reduce the duration of their effect. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4582018 Mon, 14 Mar 2011 19:26:08 +0100 4582018 Etravirine‐based highly active antiretroviral therapy in HIV‐1‐infected paediatric patients http://www.medworm.com/index.php?rid=4582020&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00907.x ConclusionsWe observed a sustained antiviral response and improved immunological parameters in multidrug‐resistant paediatric patients, most of whom had received etravirine as part of salvage regimens with at least two fully active drugs. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4582020 Sun, 13 Mar 2011 00:00:00 +0100 4582020 Computerized testing augments pencil‐and‐paper tasks in measuring HIV‐associated mild cognitive impairment* http://www.medworm.com/index.php?rid=4582019&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00910.x Conclusion This application of modern test development techniques shows a path towards a quick, quantitative, global approach to cognitive assessment with promise both for initial detection and for longitudinal follow‐up of cognitive impairment in patients with HIV infection. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4582019 Sun, 13 Mar 2011 00:00:00 +0100 4582019 Different distributions of hepatitis C virus genotypes among HIV‐infected patients with acute and chronic hepatitis C according to interleukin‐28B genotype http://www.medworm.com/index.php?rid=4555362&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00912.x Conclusions Among HIV‐infected patients with CHC, those bearing the IL‐28B genotype CC were more commonly infected with genotype 3 than subjects with non‐CC genotypes, whereas in HIV‐infected subjects with AHC this finding was not obtained. These results strongly suggest that the protective effect of the CC genotype against evolution to CHC is mainly exerted in patients infected with HCV genotype 1 or 4. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4555362 Mon, 07 Mar 2011 19:39:28 +0100 4555362 Identification and frequency of CCR5Δ32/Δ32 HIV‐resistant cord blood units from Houston area hospitals http://www.medworm.com/index.php?rid=4555364&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00911.x Conclusions Routine genotyping to identify HIV‐resistant CBUs could create a bank of CB‐derived stem/progenitor cells with which to treat HIV infection. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4555364 Sun, 06 Mar 2011 00:00:00 +0100 4555364 Cardiovascular risk assessment in persons with HIV infection in the developing world: comparing three risk equations in a cohort of HIV‐infected Thais http://www.medworm.com/index.php?rid=4555363&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2011.00916.x Conclusion The predicted cardiovascular risk in this HIV‐infected Thai cohort was relatively low. The agreement among the Rama‐EGAT and D:A:D risk scores suggests that both equations may be appropriate estimators of cardiovascular risk in this population. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4555363 Sun, 06 Mar 2011 00:00:00 +0100 4555363 Safety and pharmacokinetics of etravirine in pregnant HIV‐1‐infected women* http://www.medworm.com/index.php?rid=4545997&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00874.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4545997 Fri, 04 Mar 2011 17:45:43 +0100 4545997 Pharmacogenetic screening: HLA‐B*5701 vs. CYP2B6 G516T http://www.medworm.com/index.php?rid=4545995&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00870.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4545995 Fri, 04 Mar 2011 17:45:42 +0100 4545995 Increased detection of the HIV‐1 reverse transcriptase M184V mutation using mutation‐specific minority assays in a UK surveillance study suggests evidence of unrecognized transmitted drug resistance* http://www.medworm.com/index.php?rid=4545994&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00882.x ConclusionsFuture surveillance studies of TDR in the United Kingdom should consider combining standard genotyping and minority‐specific assays to provide more accurate estimates, particularly when using specimens collected from chronic HIV infections in which TDR variants may have declined to low levels. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4545994 Fri, 04 Mar 2011 17:45:41 +0100 4545994 Does the M184V resistance mutation in reverse transcriptase reduce HIV transmission?* http://www.medworm.com/index.php?rid=4545992&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00883.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4545992 Fri, 04 Mar 2011 17:45:36 +0100 4545992 Stabilization of HIV incidence in women of reproductive age in southern Mozambique http://www.medworm.com/index.php?rid=4513802&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00908.x Conclusion These findings indicate an increase in the prevalence and incidence of HIV infection among women of reproductive age over the 9 years of the analysis, with a plateau in the incidence of infection since 2005. However, the very high figures for both prevalence and incidence highlight the importance of the continuation of the prevention and treatment programmes that already exist, and suggest that implementation of preventive measures is needed in this area. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4513802 Thu, 24 Feb 2011 17:41:51 +0100 4513802 Growth hormone axis treatments for HIV‐associated lipodystrophy: a systematic review of placebo‐controlled trials http://www.medworm.com/index.php?rid=4401478&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00906.x ConclusionsOur review indicates that, based on the findings of the 10 included studies, GH axis treatments are effective in reducing VAT and increasing LBM in patients with HIV‐associated lipodystrophy. However, clinicians must decide whether the attributed benefits are clinically significant, considering the costs and potential risks of GH axis treatments. A limitation of this study is the small number of studies available of each GH axis drug class. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4401478 Thu, 27 Jan 2011 16:25:22 +0100 4401478 Influenza A H1N1 in HIV‐infected adults* http://www.medworm.com/index.php?rid=4390503&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00905.x ConclusionsHIV infection did not increase the severity of influenza A H1N1 infection, and influenza A H1N1 infection did not have a major effect on HIV infection. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4390503 Mon, 24 Jan 2011 19:22:52 +0100 4390503 Fatty liver disease is associated with underlying cardiovascular disease in HIV‐infected persons* http://www.medworm.com/index.php?rid=4378984&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00904.x Conclusions Coronary atherosclerosis as detected using CAC is prevalent among young HIV‐infected persons. The detection of fatty liver disease among HIV‐infected adults should prompt consideration of assessment for underlying cardiovascular disease and risk factor reduction. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4378984 Fri, 21 Jan 2011 16:24:21 +0100 4378984 A study of fatty acid binding protein 4 in HIV‐1 infection and in combination antiretroviral therapy‐related metabolic disturbances and lipodystrophy http://www.medworm.com/index.php?rid=4373817&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00903.x ConclusionscART‐treated HIV‐1‐infected patients with lipodystrophy have a systemic overproduction of FABP‐4, which is closely linked to insulin resistance and inflammatory markers in subcutaneous adipose tissue. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4373817 Thu, 20 Jan 2011 16:19:41 +0100 4373817 Management of resistant mucocutaneous herpes simplex infections in AIDS patients: a clinical and virological challenge http://www.medworm.com/index.php?rid=4378987&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00896.x ConclusionsChronic mucocutaneous HSV infection in AIDS patients remains a rare but regularly observed infection in very immunosuppressed patients or those with unstable immunity during HAART. Virological results obtained from mucocutaneous samples were in most cases found to be correlated with clinical evolution and should therefore be used in making decisions on treatment. Despite efficient antiviral therapy, mucocutaneous healing is slow in the majority of cases. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4378987 Thu, 20 Jan 2011 00:00:00 +0100 4378987 Rates of cardiovascular disease following smoking cessation in patients with HIV infection: results from the D:A:D study* http://www.medworm.com/index.php?rid=4378986&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00901.x ConclusionThe risk of CVD events in HIV‐positive patients decreased with increasing time since stopping smoking. Smoking cessation efforts should be a priority in the management of HIV‐positive patients. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4378986 Thu, 20 Jan 2011 00:00:00 +0100 4378986 Use of neonatal post‐exposure prophylaxis for prevention of mother‐to‐child HIV transmission in the UK and Ireland, 2001–2008 http://www.medworm.com/index.php?rid=4378985&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00902.x Conclusion Between 2001 and 2008, almost all infants born to HIV‐infected women in the UK and Ireland received antiretroviral PEP, mostly with one drug. Use of triple PEP increased over time, particularly for infants whose mothers were untreated or viraemic despite HAART, in line with current guidelines. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4378985 Thu, 20 Jan 2011 00:00:00 +0100 4378985 HIV/hepatitis C virus and HIV/hepatitis B virus coinfections protect against antiretroviral‐related hyperlipidaemia http://www.medworm.com/index.php?rid=4363981&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00897.x ConclusionsHIV/HCV and to a lesser extent HIV/HBV coinfections are protective against HAART‐related hyperlipidaemia. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4363981 Wed, 19 Jan 2011 16:26:42 +0100 4363981 Viral response in stable patients switching to fosamprenavir/ritonavir monotherapy (the FONT Study) http://www.medworm.com/index.php?rid=4373819&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00898.x ConclusionsThe high percentage of patients with VF in our study suggests that the use of FPV/r in a simplification monotherapy strategy should be discouraged. Adequate amprenavir levels and undetectable VL in CSF were documented in all samples evaluated. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4373819 Wed, 19 Jan 2011 00:00:00 +0100 4373819 Clinical relevance of cytomegalovirus viraemia* http://www.medworm.com/index.php?rid=4373818&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00900.x ConclusionQuantitative CMV DNA detected in the plasma of HIV‐infected patients with CD4 counts ≤100 cells/μL is a predictor for HIV disease progression, CMV disease and death. A single low value of 80 copies/mL identifies patients at low but significantly increased risk during the following months, after the measurement. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4373818 Wed, 19 Jan 2011 00:00:00 +0100 4373818 Erratum http://www.medworm.com/index.php?rid=4286166&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00858.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4286166 Fri, 24 Dec 2010 17:01:06 +0100 4286166 Can antiretroviral therapy be safely interrupted and, if so, when? http://www.medworm.com/index.php?rid=4286165&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00853.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4286165 Fri, 24 Dec 2010 17:01:06 +0100 4286165 Waist circumference and body mass index in HIV infection http://www.medworm.com/index.php?rid=4286164&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00852.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4286164 Fri, 24 Dec 2010 17:01:05 +0100 4286164 Evaluation of glomerular filtration rate in HIV‐1‐infected patients before and after combined antiretroviral therapy exposure* http://www.medworm.com/index.php?rid=4226871&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00855.x ConclusionsWe observed a relatively high rate of mild renal dysfunction in the absence of ART. In addition to traditional risk factors such as older age and diabetes/hypertension, female gender and current use of ddI, tenofovir and protease inhibitors were associated with a greater risk of decreased renal function as measured by eGFR. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4226871 Sat, 04 Dec 2010 02:15:36 +0100 4226871 The difficulties of classifying renal disease in HIV‐infected patients* http://www.medworm.com/index.php?rid=4226870&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00854.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4226870 Sat, 04 Dec 2010 02:15:35 +0100 4226870 US national estimation of emergency department utilization by patients given ‘HIV/AIDS‐related illness’ as their primary diagnosis http://www.medworm.com/index.php?rid=4145686&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00888.x ConclusionsAlthough HRIPD visits were infrequent relative to all ED visits, HRIPD visits utilized significantly more resources than non‐HRIPD visits and the utilization also increased over time. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4145686 Mon, 08 Nov 2010 00:00:00 +0100 4145686 Factors associated with virological suppression among HIV‐positive individuals on highly active antiretroviral therapy in a multi‐site Canadian cohort http://www.medworm.com/index.php?rid=4145685&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00890.x ConclusionIdentification of patients at risk for diminished likelihood of virological suppression will allow focusing of efforts and the utilization of resources to maximize the benefits of HAART. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4145685 Mon, 08 Nov 2010 00:00:00 +0100 4145685 Responses to highly active antiretroviral therapy and clinical events in patients with a low CD4 cell count: late presenters vs. late starters http://www.medworm.com/index.php?rid=4136078&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00881.x Conclusion Amongst patients who initiate, and remain on, HAART, late presentation is associated with lower rates of virological suppression, blunted CD4 cell count increases and more clinical events compared with late starters in year 1, but similar clinical and immunological outcomes by year 2 to those of both late and ideal starters. Differences between late presenters and late starters suggest that factors other than CD4 cell count alone may be driving adverse treatment outcomes in late‐presenting individuals. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4136078 Wed, 03 Nov 2010 00:00:00 +0100 4136078 Travel for HIV care in England: a choice or a necessity? http://www.medworm.com/index.php?rid=4192798&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00891.x ConclusionIn England, 81% of HIV‐infected patients live within 5 km of HIV services and a quarter of HIV‐infected adults travel to non‐local HIV services. Those living in deprived areas are less likely to travel to non‐local services. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4192798 Mon, 01 Nov 2010 00:00:00 +0100 4192798 The effectiveness of pneumococcal polysaccharide vaccination in HIV‐infected adults: a systematic review http://www.medworm.com/index.php?rid=4145684&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00892.x ConclusionsThe current clinical evidence provides only moderate support for PPV‐23 immunization of HIV‐infected adults. More data are needed on the efficacy of newer conjugated pneumococcal vaccines, which may be more immunogenic and could potentially replace PPV‐23 in the future. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4145684 Mon, 01 Nov 2010 00:00:00 +0100 4145684 Antiviral activity of apricitabine in treatment‐experienced HIV‐1‐infected patients with M184V who are failing combination therapy http://www.medworm.com/index.php?rid=4136077&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00887.x Conclusions Over the 21‐day treatment period, ATC showed promising antiviral activity and was well tolerated in treatment‐experienced patients with M184V, with or without additional TAMs. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4136077 Mon, 01 Nov 2010 00:00:00 +0100 4136077 A note of thanks to referees for Volume 11, 2010 http://www.medworm.com/index.php?rid=4090670&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00894.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4090670 Sun, 24 Oct 2010 04:39:27 +0100 4090670 British HIV Association guidelines for antiretroviral treatment of HIV‐2‐positive individuals 2010 http://www.medworm.com/index.php?rid=4090669&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00889.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4090669 Sun, 24 Oct 2010 04:39:24 +0100 4090669 Cohort profile: the German ClinSurv HIV project – a multicentre open clinical cohort study supplementing national HIV surveillance http://www.medworm.com/index.php?rid=4079066&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00879.x Background (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4079066 Thu, 30 Sep 2010 23:00:00 +0100 4079066 Trends over time of virological and immunological characteristics in the Swiss HIV Cohort Study* http://www.medworm.com/index.php?rid=4079065&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00880.x Background (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4079065 Thu, 30 Sep 2010 23:00:00 +0100 4079065 Efficacy, tolerability and risk factors for virological failure of darunavir‐based therapy for treatment‐experienced HIV‐infected patients: the Swiss HIV Cohort Study http://www.medworm.com/index.php?rid=4079064&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00885.x Objectives (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4079064 Thu, 30 Sep 2010 23:00:00 +0100 4079064 Increased detection of the HIV‐1 reverse transcriptase M184V mutation using mutation‐specific minority assays in a UK surveillance study suggests evidence of unrecognized transmitted drug resistance http://www.medworm.com/index.php?rid=4069247&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00882.x Objectives (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4069247 Thu, 30 Sep 2010 23:00:00 +0100 4069247 Pregnancy and HIV transmission among HIV‐discordant couples in a clinical trial in Kisumu, Kenya http://www.medworm.com/index.php?rid=4069246&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00884.x Objectives (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4069246 Thu, 30 Sep 2010 23:00:00 +0100 4069246 Evaluation of the possible influence of hepatitis C virus and liver fibrosis on HIV type 1 immunological and virological outcomes http://www.medworm.com/index.php?rid=4069245&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00886.x Objectives (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=4069245 Thu, 30 Sep 2010 23:00:00 +0100 4069245 A comparison of the long‐term durability of nevirapine, efavirenz and lopinavir in routine clinical practice in Europe: a EuroSIDA study http://www.medworm.com/index.php?rid=3917287&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00877.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3917287 Tue, 31 Aug 2010 23:00:00 +0100 3917287 Pregnancy in HIV‐infected teenagers in London http://www.medworm.com/index.php?rid=3913793&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00878.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3913793 Mon, 30 Aug 2010 06:34:41 +0100 3913793 ORIGINAL RESEARCH: Prediction of response to antiretroviral therapy by human experts and by the EuResist data‐driven expert system (the EVE study) http://www.medworm.com/index.php?rid=3883141&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00871.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3883141 Fri, 20 Aug 2010 06:24:45 +0100 3883141 ORIGINAL RESEARCH: HIV and risk of venous thromboembolism: a Danish nationwide population‐based cohort study http://www.medworm.com/index.php?rid=3878554&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00869.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3878554 Thu, 19 Aug 2010 06:28:51 +0100 3878554 ORIGINAL RESEARCH: Antiretroviral therapy during pregnancy and premature birth: analysis of Swiss data http://www.medworm.com/index.php?rid=3874197&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00876.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3874197 Wed, 18 Aug 2010 06:27:53 +0100 3874197 Bone mineral density changes in protease inhibitor‐sparing vs. nucleoside reverse transcriptase inhibitor‐sparing highly active antiretroviral therapy: data from a randomized trial* http://www.medworm.com/index.php?rid=3867917&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00864.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3867917 Mon, 16 Aug 2010 07:46:20 +0100 3867917 Predictors of bacterial pneumonia in Evaluation of Subcutaneous Interleukin‐2 in a Randomized International Trial (ESPRIT) http://www.medworm.com/index.php?rid=3917288&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00875.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3917288 Sat, 31 Jul 2010 23:00:00 +0100 3917288 Recruitment of HIV/AIDS treatment‐naïve patients to clinical trials in the highly active antiretroviral therapy era: influence of gender, sexual orientation and race http://www.medworm.com/index.php?rid=3913795&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00867.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3913795 Sat, 31 Jul 2010 23:00:00 +0100 3913795 Overcoming obstacles to late presentation for HIV infection in Europe http://www.medworm.com/index.php?rid=3913794&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00872.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3913794 Sat, 31 Jul 2010 23:00:00 +0100 3913794 ORIGINAL RESEARCH: Therapeutic drug monitoring of lopinavir/ritonavir in pregnancy http://www.medworm.com/index.php?rid=3878555&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00865.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3878555 Sat, 31 Jul 2010 23:00:00 +0100 3878555 ORIGINAL RESEARCH: Favourable evolution of virological and immunological profiles in treated and untreated patients in Italy in the period 1998–2008 http://www.medworm.com/index.php?rid=3874199&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00866.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3874199 Sat, 31 Jul 2010 23:00:00 +0100 3874199 ORIGINAL RESEARCH: A decade of the sperm‐washing programme: correlation between markers of HIV and seminal parameters http://www.medworm.com/index.php?rid=3874198&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00868.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3874198 Sat, 31 Jul 2010 23:00:00 +0100 3874198 Long‐term follow‐up of 11 protease inhibitor (PI)‐naïve and PI‐treated HIV‐infected patients harbouring virus with insertions in the HIV‐1 protease gene http://www.medworm.com/index.php?rid=3867919&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00862.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3867919 Sat, 31 Jul 2010 23:00:00 +0100 3867919 The HIV protease inhibitor lopinavir/ritonavir (Kaletra) alters the growth, differentiation and proliferation of primary gingival epithelium http://www.medworm.com/index.php?rid=3867918&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00863.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3867918 Sat, 31 Jul 2010 23:00:00 +0100 3867918 Hepatitis C virus coinfection and the risk of cardiovascular disease among HIV‐infected patients http://www.medworm.com/index.php?rid=3836816&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2009.00815.x Background (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3836816 Sat, 31 Jul 2010 23:00:00 +0100 3836816 Risk of high‐level viraemia in HIV‐infected patients on successful antiretroviral treatment for more than 6 months http://www.medworm.com/index.php?rid=3836815&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2009.00813.x Objectives (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3836815 Sat, 31 Jul 2010 23:00:00 +0100 3836815 Prevention of mother‐to‐child transmission of HIV in Denmark, 1994–2008 http://www.medworm.com/index.php?rid=3836814&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2009.00811.x Objectives (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3836814 Sat, 31 Jul 2010 23:00:00 +0100 3836814 The evolving burden of HIV infection compared with other chronic diseases in northern Italy* http://www.medworm.com/index.php?rid=3792132&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00861.x The aim of the study was to estimate the burden and direct costs of diseases in HIV-infected patients (either opportunistic illnesses or other chronic diseases) with respect to the HIV-uninfected population. These estimates will be useful for the projection of future direct costs of HIV care. A population-based study was conducted in the Brescia Local Health Agency in northern Italy. An administrative database recorded diagnoses, deaths, drug prescriptions and health resource utilization for all medical and surgical patients in the region from 2003 to 2007. The study estimated the prevalence of HIV infection as well as HIV-related mortality and annual cost per patient, and compared mortality and costs related to HIV infection with those for a set of 15 other chronic diseases. The standardi... HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3792132 Tue, 27 Jul 2010 23:00:00 +0100 3792132 Nevirapine-associated hepatotoxicity was not predicted by CD4 count ≥250 cells/μL among women in Zambia, Thailand and Kenya http://www.medworm.com/index.php?rid=3792133&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00873.x The aim of the study was to determine risk factors for developing severe hepatotoxicity (grade 3 or 4 hepatotoxicity) and rash-associated hepatotoxicity (rash with [ge]grade 2 hepatotoxicity) among women initiating nevirapine-based antiretroviral therapy (ART). The Non-Nucleoside Reverse Transcriptase Inhibitor Response Study was a prospective cohort study carried out in Zambia, Thailand and Kenya. Between May 2005 and January 2007, we enrolled antiretroviral-naïve HIV-infected women initiating nevirapine-based ART. At enrolment and at weeks 2, 4, 8, 16 and 24, participants had serum alanine transferase (ALT) and aspartate transaminase (AST) measured and were evaluated clinically for hepatitis and rash. Nevirapine-based ART was initiated in 820 women and baseline ALT or AST results were a... HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3792133 Sun, 25 Jul 2010 23:00:00 +0100 3792133 Detecting impaired glucose tolerance or type 2 diabetes mellitus by means of an oral glucose tolerance test in HIV-infected patients http://www.medworm.com/index.php?rid=3744857&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00860.x As a proactive diagnosis of diabetes mellitus (DM) may prevent the onset of severe complications, we used an oral glucose tolerance test (OGTT) to check for impaired glucose tolerance (IGT) and DM in patients with long-standing HIV infection and long durations of exposure to antiretroviral drugs with normal fasting plasma glucose (FPG) levels. This was a cross-sectional, single-centre study. The homeostatic model assessment for insulin resistance (HOMA-IR) and 2-h post-load glucose levels were used to evaluate patients with known HIV-1 infection since before 1988 and no previous diagnosis of DM for whom data on hepatitis C virus (HCV) and hepatitis B virus (HBV) infection were available. Eighty-four Caucasian patients [67 (80%) male; median age 45.7 years; range 43.8[ndash]49.1 years] were... HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3744857 Mon, 12 Jul 2010 23:00:00 +0100 3744857 Detecting impaired glucose tolerance or type 2 diabetes mellitus by means of an oral glucose tolerance test in HIV‐infected patients http://www.medworm.com/index.php?rid=3836787&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00860.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3836787 Wed, 30 Jun 2010 23:00:00 +0100 3836787 Nevirapine‐associated hepatotoxicity was not predicted by CD4 count ≥250 cells/μL among women in Zambia, Thailand and Kenya http://www.medworm.com/index.php?rid=3836786&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00873.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3836786 Wed, 30 Jun 2010 23:00:00 +0100 3836786 Evaluation of glomerular filtration rate in HIV-1-infected patients before and after combined antiretroviral therapy exposure http://www.medworm.com/index.php?rid=3692952&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00855.x The prevalence and factors associated with an increased risk of renal dysfunction in HIV-infected patients receiving or not receiving antiretroviral therapy (ART) have been poorly evaluated in observational settings. Patients in the ICONA Foundation cohort with at least two creatinine values available while still ART-naïve were enrolled in the study. A logistic regression analysis was performed to identify predictors of an estimated glomerular filtration rate (eGFR)20% reduction in eGFR from pre-combination ART (cART) levels (or a decrease from [ge]90 to (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3692952 Thu, 24 Jun 2010 23:00:00 +0100 3692952 Quantifying the risks and benefits of efavirenz use in HIV-infected women of childbearing age in the USA http://www.medworm.com/index.php?rid=3673866&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00856.x The aim of the study was to quantify the benefits (life expectancy gains) and risks (efavirenz-related teratogenicity) associated with using efavirenz in HIV-infected women of childbearing age in the USA. We used data from the Women's Interagency HIV Study in an HIV disease simulation model to estimate life expectancy in women who receive an efavirenz-based initial antiretroviral regimen compared with those who delay efavirenz use and receive a boosted protease inhibitor-based initial regimen. To estimate excess risk of teratogenic events with and without efavirenz exposure per 100 000 women, we incorporated literature-based rates of pregnancy, live births, and teratogenic events into a decision analytic model. We assumed a teratogenicity risk of 2.90 events/100 live births in women expose... HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3673866 Fri, 18 Jun 2010 23:00:00 +0100 3673866 Late presentation of HIV infection: a consensus definition http://www.medworm.com/index.php?rid=3668411&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00857.x The objective of this article is to present a consensus definition of late presentation of HIV infection. Over the past year, two initiatives have moved towards a harmonized definition. In spring 2009, they joined efforts to identify a common definition of what is meant by a 'late-presenting' patient. Two definitions were agreed upon, as follows. Late presentation: persons presenting for care with a CD4 count below 350 cells/[mu]L or presenting with an AIDS-defining event, regardless of the CD4 cell count. Presentation with advanced HIV disease: persons presenting for care with a CD4 count below 200 cells/[mu]L or presenting with an AIDS-defining event, regardless of the CD4 cell count. The European Late Presenter Consensus working group believe it would be beneficial if all national healt... HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3668411 Thu, 17 Jun 2010 23:00:00 +0100 3668411 Doctor–patient concordance during HIV treatment switching decision-making http://www.medworm.com/index.php?rid=3668412&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00851.x The aim of the study was to explore levels of doctor[ndash]patient concordance during the making of decisions regarding HIV treatment switching and stopping in relation to patient health-related outcomes. Adult patients attending five HIV clinics in the United Kingdom were requested to complete the study questionnaire, which included a Concordance Scale, and measures of symptoms [Memorial Symptom Assessment Short Form (MSAS) index], quality of life (EuroQol), satisfaction, adherence and sexual risk behaviour. Clinical health measures (HIV viral load and CD4 cell count) were also obtained. A total of 779 patients completed the questionnaire, giving a response rate of 86%; of these 779 patients, 430 had switched or stopped their HIV treatment and were thus eligible for inclusion. Of these pa... HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3668412 Wed, 16 Jun 2010 23:00:00 +0100 3668412 Screening for acute HIV infection in South Africa: finding acute and chronic disease* http://www.medworm.com/index.php?rid=3650329&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00850.x The yield of screening for acute HIV infection among general medical patients in resource-scarce settings remains unclear. Our objective was to evaluate the strategy of using pooled HIV plasma RNA to diagnose acute HIV infection in patients with negative or discordant rapid HIV antibody tests in Durban, South Africa. We prospectively enrolled patients with negative or discordant rapid HIV antibody tests from a routine HIV screening programme in an out-patient department in Durban with an HIV prevalence of 48%. Study participants underwent venipuncture for pooled qualitative HIV RNA, and, if this was positive, quantitative RNA, enzyme immunoassay and Western blot (WB). Patients with negative or indeterminate WB and positive quantitative HIV RNA were considered acutely infected. Those with c... HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3650329 Thu, 10 Jun 2010 23:00:00 +0100 3650329 Doctor–patient concordance during HIV treatment switching decision‐making http://www.medworm.com/index.php?rid=3836803&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00851.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3836803 Mon, 31 May 2010 23:00:00 +0100 3836803 Quantifying the risks and benefits of efavirenz use in HIV‐infected women of childbearing age in the USA http://www.medworm.com/index.php?rid=3836802&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00856.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3836802 Mon, 31 May 2010 23:00:00 +0100 3836802 Evaluation of glomerular filtration rate in HIV‐1‐infected patients before and after combined antiretroviral therapy exposure http://www.medworm.com/index.php?rid=3836801&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00855.x (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3836801 Mon, 31 May 2010 23:00:00 +0100 3836801 The suppression of immune activation during enfuvirtide-based salvage therapy is associated with reduced CCR5 expression and decreased concentrations of circulating interleukin-12 and IP-10 during 48 weeks of longitudinal follow-up http://www.medworm.com/index.php?rid=3593443&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00848.x This study shows that suppression of HIV-1 replication with enfuvirtide-based salvage therapy in patients with low CD4 cell counts may result in an immunological benefit, characterized by the restoration of CD4 T-cell subsets associated with decreased immune activation and suppression of inflammation. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3593443 Mon, 24 May 2010 23:00:00 +0100 3593443 Coinfection with hepatitis C virus, oxidative stress and antioxidant status in HIV-positive drug users in Miami* http://www.medworm.com/index.php?rid=3591205&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00849.x We examined markers of oxidative stress, plasma antioxidants and liver disease in HIV/HCV-coinfected and HIV-monoinfected adults. Demographics, medical history, and proof of infection with HIV, hepatitis A virus (HAV), hepatitis B virus (HBV) and HCV were obtained. HIV viral load, CD4 cell count, complete blood count (CBC), complete metabolic panel, lipid profile, and plasma concentrations of zinc, selenium, and vitamins A and E were determined. Malondialdehyde (MDA) and glutathione peroxidase concentrations were obtained as measures of oxidative stress. Aminotransferase to platelet ratio index (APRI) and fibrosis index (FIB-4) markers were calculated. Significant differences were found between HIV/HCV-coinfected and HIV-monoinfected participants in levels of alanine aminotransferase (ALT)... HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3591205 Sun, 23 May 2010 23:00:00 +0100 3591205 'Active chronic visceral leishmaniasis' in HIV-1-infected patients demonstrated by biological and clinical long-term follow-up of 10 patients http://www.medworm.com/index.php?rid=3591207&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00846.x The aim of the study was to describe a new evolutionary form of visceral leishmaniasis observed in immunocompromised patients. We carried out long-term clinical and biological follow-up of 10 HIV-1/Leishmania-coinfected patients presenting numerous secondary visceral leishmaniasis episodes despite treatment, with the follow-up time ranging from 0.5 to 10 years. Analysis of polymerase chain reaction (PCR) and blood culture results demonstrated continuous multiplication and circulation of parasites despite treatment, both during asymptomatic periods and during secondary visceral leishmaniasis episodes. This condition may be termed 'chronic' because of the presence of relapses over a period of several years and 'active' because of the continuous blood circulation of the parasite. We wish to d... HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3591207 Sat, 22 May 2010 23:00:00 +0100 3591207 Impact of antiretroviral treatment on 13C-methionine metabolism as a marker of hepatic mitochondrial function: a longitudinal study http://www.medworm.com/index.php?rid=3591206&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00847.x Uncontrolled viral replication and antiretroviral treatment (ART) may independently contribute to hepatic mitochondrial toxicity. The present study was designed to explore the longitudinal effects of treatment modifications on hepatic mitochondrial function by means of noninvasive 13C-methionine breath test (MeBT) diagnostics. A total of 113 HIV-infected patients underwent two consecutive MeBTs over an interval of 11.8±3.5 months. Forty-nine patients remained on stable ART or no therapy; 28 participants switched ART; 27 patients (re)initiated ART, and nine individuals underwent a structured treatment interruption (STI) of ART between MeBTs 1 and 2. Breath test results were expressed as cumulative percentage dose of 13CO2 recovered after 1.5 h test time (cPDR1.5h). Initiation of ART in tre... HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3591206 Sat, 22 May 2010 23:00:00 +0100 3591206 Pharmacokinetics, protein-binding-adjusted inhibitory quotients for atazanavir/ritonavir 300/100 mg in treatment-naïve HIV-infected patients* http://www.medworm.com/index.php?rid=3583289&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00839.x This study showed that the protein-binding-adjusted IQ of atazanavir is close to those measured for lopinavir and darunavir used once daily in first-line treatment. Finally the selection of resistance in the case of virological failure (plasma viral load >400 HIV-1 RNA copies/mL) to atazanavir/ritonavir used in first-line therapy seems uncommon, as it is for all boosted PIs. (Source: HIV Medicine) HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3583289 Thu, 20 May 2010 23:00:00 +0100 3583289 The effects of enfuvirtide therapy on body composition and metabolic parameters over 48 weeks in the TORO body imaging substudy* http://www.medworm.com/index.php?rid=3571305&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00845.x The aim of the study was to compare the metabolic and morphological effects of enfuvirtide plus an optimized background (OB) regimen vs. OB alone (control group) in treatment-experienced patients in the T-20 vs. Optimized Regimen Only (TORO) studies. Body composition and metabolic changes were investigated in patients over 48 weeks, based on fasting chemistries, body weight, and other anthropometric measurements. Dual-energy X-ray absorptiometry (DEXA) and computed tomography (CT) scans were performed in a patient subgroup (n=155) at baseline and at weeks 24 and 48. At week 48, mean changes from baseline were similar between treatment groups for glucose, insulin, C-peptide, total cholesterol, low-density lipoprotein (LDL) cholesterol, very low density lipoprotein (VLDL) cholesterol, high-d... HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3571305 Mon, 17 May 2010 23:00:00 +0100 3571305 Combined use of aspartate aminotransferase, platelet count and matrix metalloproteinase 2 measurements to predict liver fibrosis in HIV/hepatitis C virus-coinfected patients http://www.medworm.com/index.php?rid=3571309&cid=s_33106_20_f&fid=33106&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1468-1293.2010.00836.x Noninvasive tests that can be used in place of liver biopsy to diagnose fibrosis have major limitations. They either leave a significant proportion of patients without a definitive diagnosis or produce inaccurate results. Moreover, the performance of these tests is lower in HIV/hepatitis C virus (HCV) coinfection. Against this background, we examined the utility of serum matrix metalloproteinase 2 (MMP-2) and tissue inhibitor of metalloproteinase 1 (TIMP-1) measurements in combination with routine clinical data to predict fibrosis in HIV/HCV-coinfected patients. Patients with a liver biopsy who had not received anti-HCV therapy were included in the study. A model including variables independently associated with fibrosis was constructed. Diagnostic accuracy was determined by measuring the ... HIV Medicine journals http://www.medworm.com/rss/comments.php?id=3571309 Sun, 16 May 2010 23:00:00 +0100 3571309