MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Haematologica' source. Sun, 14 Mar 2010 14:25:22 +0100 http://www.medworm.com/index.php?rid=3359287&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20220059%26dopt%3DAbstract CONCLUSION The (R)VAD+C is an effective regimen with very low toxicity. In addition to the MIPI score, Ki67 expression provides additional independent prognostic information for the prediction of OS. PMID: 20220059 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3359287 Wed, 10 Mar 2010 00:00:00 +0100 3359287 http://www.medworm.com/index.php?rid=3359286&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20220060%26dopt%3DAbstract Conclusions Our results suggest that hematopoietic tumors display a highly variable repertoire of surface proteins that can impact on VgammaVdelta cell-mediated immunotargeting. The prognostic value of the proposed markers can now be evaluated in upcoming VgammaVdelta T cell-based lymphoma/ leukaemia clinical trials. PMID: 20220060 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3359286 Wed, 10 Mar 2010 00:00:00 +0100 3359286 http://www.medworm.com/index.php?rid=3359285&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20220061%26dopt%3DAbstract Conclusions Macrophage ferroportin is present in lipid rafts which contribute to hepcidin activity. These observations reveal the existence of a new cellular pathway in hepcidin mediated degradation of ferroportin and open a new area of investigation in mammalian iron homeostasis. PMID: 20220061 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3359285 Wed, 10 Mar 2010 00:00:00 +0100 3359285 http://www.medworm.com/index.php?rid=3359284&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20220062%26dopt%3DAbstract Conclusions Our findings provide evidence that the change of Peak on day 7 relative to pre-treatment levels may be a relevant biomarker for early identification of patients who may fail from conventional induction chemotherapy. PMID: 20220062 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3359284 Wed, 10 Mar 2010 00:00:00 +0100 3359284 http://www.medworm.com/index.php?rid=3359283&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20220063%26dopt%3DAbstract Conclusions These results indicate the benefit of early intervention during imatinib therapy. PMID: 20220063 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3359283 Wed, 10 Mar 2010 00:00:00 +0100 3359283 http://www.medworm.com/index.php?rid=3359282&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20220064%26dopt%3DAbstract Conclusions: Our data suggest that SDRPSBCL is a distinct entity with morphological and immunophenotypic features that differ from those of other splenic lymphomas. PMID: 20220064 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3359282 Wed, 10 Mar 2010 00:00:00 +0100 3359282 http://www.medworm.com/index.php?rid=3359281&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20220065%26dopt%3DAbstract We describe four CN patients with mutations in two candidate genes each, including 6 novel mutations. Two of them had a heterozygous ELANE mutation combined with a homozygous mutation in G6PC3 or HAX1, respectively. The other two patients combined homozygous or compound heterozygous mutations in G6PC3 or HAX1 with a heterozygous mutation in the respective other gene. Our results suggest that digenicity may underlie this disorder of myelopoiesis at least in some CN patients. PMID: 20220065 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3359281 Wed, 10 Mar 2010 00:00:00 +0100 3359281 http://www.medworm.com/index.php?rid=3359280&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20220066%26dopt%3DAbstract Conclusions Extracranial ICA stenosis is strongly associated with stroke in children with SCA, and may explain some cases of stroke without overt intracranial vasculopathy. Doppler ultrasound scanning of extracranial ICAs is non-invasive and fairly quick to perform and may identify children at increased risk of stroke who would otherwise be missed. The value of extracranial ICA scanning should be studied prospectively. PMID: 20220066 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3359280 Wed, 10 Mar 2010 00:00:00 +0100 3359280 http://www.medworm.com/index.php?rid=3359279&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20220067%26dopt%3DAbstract Conclusions This study is the first to demonstrate that HLA low expression variants are able to present peptides and, thus, can be considered as functionally active. When comparing peptide motifs, it is likely that HLA-A*3014L and HLA-A*3001 represent a permissive mismatch with low allogenicity in HSCT. These results indicate that surface expression as well as peptide-binding data of HLA variants with similar disulfide bridge variations (e.g. HLA-A*3211Q) need to be considered as functionally active in an allogeneic HSCT setting as long as the opposite has not been shown. Otherwise a relevant but not considered HLA mismatch could result in a severe allogeneic T-cell response and GvHD. PMID: 20220067 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3359279 Wed, 10 Mar 2010 00:00:00 +0100 3359279 http://www.medworm.com/index.php?rid=3359278&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20220068%26dopt%3DAbstract Authors: Tauscher J, Siegel F, Petrides PE PMID: 20220068 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3359278 Wed, 10 Mar 2010 00:00:00 +0100 3359278 http://www.medworm.com/index.php?rid=3359277&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20220069%26dopt%3DAbstract Conclusions These results have implications for the risk-adapted management for MM patients undergoing high-dose chemotherapy followed by ASCT and suggest that new treatment concepts are urgently needed for patients who belong to the poor prognosis group. As targeted therapies evolve, different treatment options might have variable success, depending on the underlying genetic nature of the clone. PMID: 20220069 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3359277 Wed, 10 Mar 2010 00:00:00 +0100 3359277 http://www.medworm.com/index.php?rid=3350715&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20207838%26dopt%3DAbstract Authors: Borgna-Pignatti C Andrea wakes up late, because the night before he went to a party with his girlfriend. He disconnects the needle and puts his desferal pump in the drawer. Then he rushes to work: he's a computer designer and his job is quite safe, because it was granted under the law protecting thalassemia patients and other people with medical problems. Nevertheless he does not want to irritate his boss. Besides, in a few days, he will be absent, and work will pile up, as he needs to go to the hospital for his regular blood transfusion. Salvatore does not sleep well. He has a cast on his leg, which makes sleeping difficult. Playing football with his friends he broke a tibia, and it is not a first. Last time it was a rib, jumping from a wall in the countryside. He lost his jo... Haematologica journals http://www.medworm.com/rss/comments.php?id=3350715 Mon, 01 Mar 2010 00:00:00 +0100 3350715 http://www.medworm.com/index.php?rid=3350714&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20207839%26dopt%3DAbstract Authors: Jädersten M PMID: 20207839 [PubMed - in process] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3350714 Mon, 01 Mar 2010 00:00:00 +0100 3350714 http://www.medworm.com/index.php?rid=3350713&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20207840%26dopt%3DAbstract Authors: Pittaluga S, Jaffe ES PMID: 20207840 [PubMed - in process] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3350713 Mon, 01 Mar 2010 00:00:00 +0100 3350713 http://www.medworm.com/index.php?rid=3350712&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20207841%26dopt%3DAbstract Authors: Laurent C, Fazilleau N, Brousset P PMID: 20207841 [PubMed - in process] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3350712 Mon, 01 Mar 2010 00:00:00 +0100 3350712 http://www.medworm.com/index.php?rid=3350711&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20207842%26dopt%3DAbstract Authors: Stone MJ, Pascual V PMID: 20207842 [PubMed - in process] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3350711 Mon, 01 Mar 2010 00:00:00 +0100 3350711 http://www.medworm.com/index.php?rid=3350710&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20207843%26dopt%3DAbstract Authors: Koreth J, Antin JH PMID: 20207843 [PubMed - in process] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3350710 Mon, 01 Mar 2010 00:00:00 +0100 3350710 http://www.medworm.com/index.php?rid=3350709&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20207844%26dopt%3DAbstract Conclusions This is the first report on Rho GTPases in human T-cell development, showing the essential role of Cdc42. Our data suggest that enhanced apoptotic death and reduced proliferation rather than disturbed migration explains the decreased thymopoiesis induced by dominant negative Cdc42. PMID: 20207844 [PubMed - in process] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3350709 Mon, 01 Mar 2010 00:00:00 +0100 3350709 http://www.medworm.com/index.php?rid=3350708&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20207845%26dopt%3DAbstract Conclusions Red cell transfusion-independence prior to treatment in mAA patients predicted response. The only significant adverse treatment-related events were transient rashes and arthralgias. Daclizumab is safe and effective, and produces lengthy remissions in patients with PRCA and mAA. PMID: 20207845 [PubMed - in process] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3350708 Mon, 01 Mar 2010 00:00:00 +0100 3350708 http://www.medworm.com/index.php?rid=3350707&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20207846%26dopt%3DAbstract Conclusions Our data suggest that silencing by BCR-ABL small interfering RNA combined with imatinib or nilotinib may be associated with an additive antileukemic activity against tyrosine kinase inhibitor-sensitive and resistant BCR-ABL cells, and might be an alternative approach to overcome BCR-ABL mutations. PMID: 20207846 [PubMed - in process] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3350707 Mon, 01 Mar 2010 00:00:00 +0100 3350707 http://www.medworm.com/index.php?rid=3350706&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20207847%26dopt%3DAbstract Conclusions ICOS is a useful molecule for identifying T(FH) cells and its restricted expression to angioimmunoblastic T-cell lymphoma and a proportion of peripheral T-cell lymphomas, not otherwise specified (showing a T(FH)-like profile) suggests its inclusion in the antibody panel for diagnosing T(FH)-derived lymphomas. Our findings provide further evidence that the histological spectrum of T(FH)-derived lymphomas is broader than previously assumed. PMID: 20207847 [PubMed - in process] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3350706 Mon, 01 Mar 2010 00:00:00 +0100 3350706 http://www.medworm.com/index.php?rid=3350705&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20207848%26dopt%3DAbstract We report 2 ALK-positive large B-cell lymphoma cases showing granular cytoplasmic and cytoplasmic/nuclear ALK immunostaining in which cryptic ALK rearrangements were identified by fluorescent in situ hybridization and molecular analysis. In the first case, the ALK-involving t(2;3)(p23;q27) masked the cryptic SEC31A-ALK fusion generated by an insertion of the 5' end of SEC31A (4q21) upstream of the 3' end of ALK. This rearrangement was associated with loss of the 5' end of ALK and duplication of SEC31A-ALK on der(20). In the second case with complex rearrangements of both chromosomes 2, a submicroscopic NPM1-ALK fusion created by insertion of the 3' end of ALK into the NPM1 locus was evidenced. Further studies of SEC31A-ALK showed that this variant fusion transforms IL3-dependent Ba/F3 cell... Haematologica journals http://www.medworm.com/rss/comments.php?id=3350705 Mon, 01 Mar 2010 00:00:00 +0100 3350705 http://www.medworm.com/index.php?rid=3350704&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20207849%26dopt%3DAbstract Authors: Pearce L, Morgan L, Lin TT, Hewamana S, Matthews RJ, Deaglio S, Rowntree C, Fegan C, Pepper C, Brennan P Studies of the role of individual genes in chronic lymphocytic leukemia (CLL) have been hampered by the inability to consistently transfect primary tumor cells. Here, we describe a highly efficient method of genetically modifying primary CLL cells using a VSVG pseudotyped lentiviral vector. We transduced CD38 negative CLL cells with a lentiviral vector encoding CD38 which caused increased surface CD38 expression in all the samples tested (n=17) with no evidence of plasmacytoid differentiation. The mean percentage of positive cells expressing CD38 was 87%+/-8.5% and the mean cell viability 74%+/-17%. This high level of transduction of all the CLL cell samples tested demonstr... Haematologica journals http://www.medworm.com/rss/comments.php?id=3350704 Mon, 01 Mar 2010 00:00:00 +0100 3350704 http://www.medworm.com/index.php?rid=3313533&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20179083%26dopt%3DAbstract Authors: Jones AV, Cross NC PMID: 20179083 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3313533 Tue, 23 Feb 2010 00:00:00 +0100 3313533 http://www.medworm.com/index.php?rid=3313532&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20179084%26dopt%3DAbstract Conclusions We have established that the characteristic changes caused by protein 4.2 deficiency occur early during erythropoiesis. We postulate that weakening of the ankyrin-1-band 3 association during protein 4.2 deficiency is compensated, in part, by increased CD44-cytoskeleton binding. PMID: 20179084 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3313532 Tue, 23 Feb 2010 00:00:00 +0100 3313532 http://www.medworm.com/index.php?rid=3313531&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20179085%26dopt%3DAbstract Conclusions Human MSC mediate protection of CML cells from imatinib-induced apoptosis. Disruption of CXCL12/CXCR4 axis at least in part restores sensitivity to imatinib. The combination of anti-CXCR4 antagonists with TK inhibitors may represent a powerful approach in the treatment of CML. PMID: 20179085 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3313531 Tue, 23 Feb 2010 00:00:00 +0100 3313531 http://www.medworm.com/index.php?rid=3313530&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20179086%26dopt%3DAbstract Conclusions Our results indicate that CD271 antigen provides a versatile marker for prospective isolation and expansion of multipotent MSCs with immunosuppressive and lymphohematopoietic engraftment-promoting properties. Their cotransplantation with HSCs in patients with hematological malignancies may prove valuable in the prevention of impaired/delayed T-cell recovery and graft-versus-host disease. PMID: 20179086 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3313530 Tue, 23 Feb 2010 00:00:00 +0100 3313530 http://www.medworm.com/index.php?rid=3313529&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20179087%26dopt%3DAbstract Conclusions The identified missense (Pro289Arg, Arg611His, Asp668Gly) and nonsense (Gly390X, Trp664X) mutations are causative for FXIII deficiency. A Gly592Ser variant identified in three unrelated index patients, as well as in 200 healthy controls (minor allele frequency 0.005), and two further Tyr167Cys and Arg540Gln variants, represent possible candidates for rare F13A gene polymorphisms since they apparently do not have a significant influence on FXIIIA protein structure. Future in vitro expression studies for these FXIII mutations are required to confirm their pathological mechanisms. PMID: 20179087 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3313529 Tue, 23 Feb 2010 00:00:00 +0100 3313529 http://www.medworm.com/index.php?rid=3313528&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20179088%26dopt%3DAbstract Authors: Elorza I, Palacio C, Dapena JL, Gallur L, de Toledo JS, Díaz de Heredia C PMID: 20179088 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3313528 Tue, 23 Feb 2010 00:00:00 +0100 3313528 http://www.medworm.com/index.php?rid=3313527&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20179089%26dopt%3DAbstract Authors: Steensma DP PMID: 20179089 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3313527 Tue, 23 Feb 2010 00:00:00 +0100 3313527 http://www.medworm.com/index.php?rid=3313526&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20179090%26dopt%3DAbstract Conclusions This finding suggests that heme controls a macrophage iron recycling regulon involving Bach1 and Nrf2 to assure the coordinated degradation of heme by HO1, iron storage and detoxification by ferritin, and iron export by FPN1. PMID: 20179090 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3313526 Tue, 23 Feb 2010 00:00:00 +0100 3313526 http://www.medworm.com/index.php?rid=3266131&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20145264%26dopt%3DAbstract Conclusions The impaired migration towards CXCL12 may reduce the access of T cells from ZAP-70(-) patients to lymphoid organs, creating a less favorable microenvironment for leukemic cell survival and proliferation. PMID: 20145264 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3266131 Tue, 09 Feb 2010 00:00:00 +0100 3266131 http://www.medworm.com/index.php?rid=3266130&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20145265%26dopt%3DAbstract Conclusions These data demonstrate previously masked mechanism of red cell clearance in PNH and suggests that blockade of complement C5 allows C3 fragment accumulation on some PNH red cells, explaining the residual low-level hemolysis occurring in some eculizumab treated patients. PMID: 20145265 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3266130 Tue, 09 Feb 2010 00:00:00 +0100 3266130 http://www.medworm.com/index.php?rid=3266129&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20145266%26dopt%3DAbstract Conclusions Patients with primary ITP are at increased risk for venous TE compared with patients without primary ITP. PMID: 20145266 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3266129 Tue, 09 Feb 2010 00:00:00 +0100 3266129 http://www.medworm.com/index.php?rid=3266128&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20145267%26dopt%3DAbstract Conclusions Our data suggest that the mesenchymal stromal cell surface is the dominant location where hematopoietic stem cells proliferate, whereas the compartment beneath the mesenchymal stromal cell layer seems to be mimicking the stem cell niche for more immature cells. The SDF-1/CXCR4 interaction and integrin-mediated cell adhesion play important roles in the distribution of hematopoietic stem cells in the coculture system. PMID: 20145267 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3266128 Tue, 09 Feb 2010 00:00:00 +0100 3266128 http://www.medworm.com/index.php?rid=3266127&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20145268%26dopt%3DAbstract Conclusions Our results indicate a fast recovery of functional and alloreactive NK cells with a constant KIR-pattern after haploidentical transplantation with T and B cell depleted grafts. Moreover, these NK cells can mediate ADCC and therefore may allow for an early use of antibodies against residual malignant cells. PMID: 20145268 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3266127 Tue, 09 Feb 2010 00:00:00 +0100 3266127 http://www.medworm.com/index.php?rid=3266126&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20145269%26dopt%3DAbstract Authors: Suttorp M, Thiede C, Tauer JT, Range U, Schlegelberger B, von Neuhoff N PMID: 20145269 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3266126 Tue, 09 Feb 2010 00:00:00 +0100 3266126 http://www.medworm.com/index.php?rid=3266125&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20145270%26dopt%3DAbstract Conclusions In conclusion, SAHA induces apoptosis in CLL cells via the extrinsic pathway and downregulates CXCR4 expression leading to decreased cell migration. SAHA in combination with other drugs represents a promising therapeutic approach to inhibiting migration, CLL cell survival and potentially overcoming drug resistance. PMID: 20145270 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3266125 Tue, 09 Feb 2010 00:00:00 +0100 3266125 http://www.medworm.com/index.php?rid=3266124&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20145271%26dopt%3DAbstract Conclusions Bone marrow infiltration with DLBCL in patients with DLBCL, NOS is rare at diagnosis. By contrast, a high number of DLBCL, NOS of the ABC subtype but not of GCB subtype is associated with MSBC in the marrow. Whether these MSBC are precursors of DLBCL of the ABC type or arise in a common background that favours clonal B-cell expansion remains to be demonstrated. PMID: 20145271 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3266124 Tue, 09 Feb 2010 00:00:00 +0100 3266124 http://www.medworm.com/index.php?rid=3266122&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20145272%26dopt%3DAbstract Conclusions A French Mediterranean regional hemochromatosis registry with strict inclusion criteria is a useful tool for characterizing the history of the disease, particularly for the most severely affected patients, as defined by the disease severity classification. Total prevalence of symptomatic C282Y homozygotes in the region was found to be low. However, clinical penetrance (stages 3 and 4) was not negligible. PMID: 20145272 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3266122 Tue, 09 Feb 2010 00:00:00 +0100 3266122 http://www.medworm.com/index.php?rid=3266121&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20145273%26dopt%3DAbstract Conclusions This is the first randomized phase III trial in pre-treated CP-CML patients demonstrating improvement in MCyR, CCyR and MMR rates with HD imatinib therapy. PMID: 20145273 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3266121 Tue, 09 Feb 2010 00:00:00 +0100 3266121 http://www.medworm.com/index.php?rid=3266120&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20145274%26dopt%3DAbstract Authors: Brault L, Gasser C, Bracher F, Huber K, Knapp S, Schwaller J The identification as cooperating targets of Proviral Integrations of Moloney virus in murine lymphomas suggested early on that PIM serine/threonine kinases play an important role in cancer biology. Whereas elevated levels of PIM1 and PIM2 were mostly found in haematological malignancies and prostate cancer, increased PIM3 expression was observed in different solid tumours. PIM kinases are constitutively active and their activity supports in vitro and in vivo tumour cell growth and survival through modification of an increasing number of common as well as isoform-specific substrates including several cell cycle regulators and apoptosis mediators. PIM1 but not PIM2 seems also to mediate homing and migration of normal ... Haematologica journals http://www.medworm.com/rss/comments.php?id=3266120 Tue, 09 Feb 2010 00:00:00 +0100 3266120 http://www.medworm.com/index.php?rid=3266119&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20145275%26dopt%3DAbstract Conclusions Simple immunophenotypic criteria are useful for therapy decisions in MPAL. In B lineage leukemia, MPAL confers poorer prognosis. However, our data did not justify a preferential use of current AML-based therapy in MPAL. PMID: 20145275 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3266119 Tue, 09 Feb 2010 00:00:00 +0100 3266119 http://www.medworm.com/index.php?rid=3266118&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20145276%26dopt%3DAbstract CONCLUSIONS: The prognosis of adult ALL patients who relapse is poor. Those aged less than 30 years with a first CR longer than 2 years have reasonable possibilities of becoming long term survivors while patients over this age or relapsing early can not be successfully rescued using the therapies currently available. PMID: 20145276 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3266118 Tue, 09 Feb 2010 00:00:00 +0100 3266118 http://www.medworm.com/index.php?rid=3247459&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20133893%26dopt%3DAbstract Conclusions In conclusion, FLT3-ITD size and PML-RARalpha transcripts levels at diagnosis could contribute to improve the risk stratification in APL. PMID: 20133893 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3247459 Thu, 04 Feb 2010 00:00:00 +0100 3247459 http://www.medworm.com/index.php?rid=3247458&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20133894%26dopt%3DAbstract Authors: Corre E, Carmagnat M, Busson M, Peffault de Latour R, Robin M, Ribaud P, Toubert A, Rabian C, Socié G In 140 consecutive patients who were 2-year disease-free and underwent myeloablative allogeneic transplantation immune reconstitution was analyzed. A CD4 and CD8 defect was observed involving naive, terminally differentiated, memory and competent cells and above limits values for activated subsets. NK cells normalize at 6 months while we observed expansion of CD19+/CD5+ B cells after 3 months and a persisting defect of memory B cells. Chronic GvHD did not influence significantly those parameters for CD8 subsets while strongly affecting the naïve and competent CD4 subsets. But the most profound impact of chronic GvHD was on B cell subsets especially on the memory B po... Haematologica journals http://www.medworm.com/rss/comments.php?id=3247458 Thu, 04 Feb 2010 00:00:00 +0100 3247458 http://www.medworm.com/index.php?rid=3247457&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20133895%26dopt%3DAbstract Authors: Hussein M, Berenson JR, Niesvizky R, Munshi N, Matous J, Sobecks R, Harrop K, Drachman JG, Whiting N This first-in-human, phase 1 study evaluated the safety, maximum-tolerated dose (MTD), pharmacokinetics, and antitumor activity of dacetuzumab in 44 patients with advanced multiple myeloma. Patients received intravenous dacetuzumab, either in 4 uniform weekly doses (first 4 cohorts) or using a 5-week intrapatient dose escalation schedule (7 subsequent cohorts; the last 3 cohorts received steroid premedication). An initial dose of 4 mg/kg dacetuzumab exceeded the MTD for uniform weekly dosing. Intrapatient dose escalation with steroid premedication appeared effective in reducing symptoms of cytokine release syndrome (CRS) and the MTD with this dosing schema was 12 mg/kg/week. Ad... Haematologica journals http://www.medworm.com/rss/comments.php?id=3247457 Thu, 04 Feb 2010 00:00:00 +0100 3247457 http://www.medworm.com/index.php?rid=3247456&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20133896%26dopt%3DAbstract Conclusions Asymptomatic parasitemia is associated with increased hepcidin concentrations and anemia, in the absence of a manifest acute phase response. Prolonged iron maldistribution may be an underestimated cause of anemia. Screening for parasitemia should be performed before start of iron supplements, as iron therapy may be less effective and even hazardous in these circumstances. PMID: 20133896 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3247456 Thu, 04 Feb 2010 00:00:00 +0100 3247456 http://www.medworm.com/index.php?rid=3247455&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20133897%26dopt%3DAbstract Conclusions These results demonstrate the potential targets of SAHA, underlining the importance of TCR signaling inhibition following vorinostat treatment. Additionaly, we show that combination therapies involving HDACi and inhibitors of PI3K can be potentially efficacious for the treatment of CTCL. PMID: 20133897 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3247455 Thu, 04 Feb 2010 00:00:00 +0100 3247455 http://www.medworm.com/index.php?rid=3247454&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20133898%26dopt%3DAbstract Conclusions Sex is an independent factor accounting for variability in the JAK2(V617F) allele burden. We speculate that lower allele burdens in females suggests a lower frequency of mitotic recombination events in females compared to males, and should be considered when evaluating the relationship of allele burden to disease phenotype and also in evaluating responses to JAK2(V617F)-inhibitors. Because sex may influence either genotype and/or clonal expansion as the underpinning to the variability in the JAK2(V617F) allele burden, it will be important to explore factors that determine susceptibility to mitotic recombination events. PMID: 20133898 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3247454 Thu, 04 Feb 2010 00:00:00 +0100 3247454 http://www.medworm.com/index.php?rid=3221501&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20107153%26dopt%3DAbstract Authors: Gianfaldoni G, Mannelli F, Ponziani V, Longo G, Bencini S, Bosi A, Vannucchi AM We investigated the prognostic significance of early peripheral blast clearance as assessed by WT1 transcript reduction during the first days of standard induction therapy in 57 adult patients with acute myeloid leukemia (AML). Quantification of WT1 transcript by realtime quantitative PCR in peripheral blood on day 1 and 5 of treatment was performed. WT1 ratio was defined as the ratio of copy number measured on day 1 and on day 5. The median WT1 ratio was greater in patients attaining CR as compared to non responders (11.68 vs 2.14, respectively; p=0.0006). Furthermore, DFS and OS were significantly longer in patients displaying a WT1 ratio > 5.82 (i.e. the median value of whole cohort) than in ... Haematologica journals http://www.medworm.com/rss/comments.php?id=3221501 Wed, 27 Jan 2010 00:00:00 +0100 3221501 http://www.medworm.com/index.php?rid=3221500&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20107154%26dopt%3DAbstract Authors: Cimino G, Cenfra N, Elia L, Sica S, Luppi M, Meloni G, Vignetti M, Paoloni F, Foà R, Mandelli F The clinical outcome of 21 adults with ALL1(MLL)/AF4 positive acute lymphoblastic leukemia enrolled in the GIMEMA LAL 2000 trial and of 25 patients entered into the previous 0496 study is reported. LAL 2000 included more intensive consolidation and transplants. Complete remission rates were 90% and 88% in the LAL 2000 and 0496 trials, respectively. Fifteen patients were transplanted (5 autologous, 10 allogeneic). At 36 months overall and disease free survivals were 32.9%, 31.8%, 28% and 27.3%, in LAL 2000 and 0496 trials, respectively. Relapses remained the main reason of failure occurring in 10 and 16 of the 19 and 22 responding patients. In the LAL 2000 study, 4 relapses were... Haematologica journals http://www.medworm.com/rss/comments.php?id=3221500 Wed, 27 Jan 2010 00:00:00 +0100 3221500 http://www.medworm.com/index.php?rid=3221498&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20107155%26dopt%3DAbstract Conclusions Surveillance investigations have no impact on management and do not improve the outcome of this population. PMID: 20107155 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3221498 Wed, 27 Jan 2010 00:00:00 +0100 3221498 http://www.medworm.com/index.php?rid=3221497&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20107156%26dopt%3DAbstract Conclusions We conclude that this Allo-RIC strategy may be associated with significant NRM in heavily pre-treated patients with FL, but a remarkable low relapse rate and long-term survival is likely in patients without progressive and refractory disease at transplant. PMID: 20107156 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3221497 Wed, 27 Jan 2010 00:00:00 +0100 3221497 http://www.medworm.com/index.php?rid=3221496&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20107157%26dopt%3DAbstract Authors: Chang H, Jiang A, Brandwein J PMID: 20107157 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3221496 Wed, 27 Jan 2010 00:00:00 +0100 3221496 http://www.medworm.com/index.php?rid=3221489&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20107158%26dopt%3DAbstract Conclusion RQ-PCR is a simple and useful adjunct standard diagnostic assays to detect clinically significant overexpression of PDGFRA and PDGFRB in Eos-MPNs or related disorders. PMID: 20107158 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3221489 Wed, 27 Jan 2010 00:00:00 +0100 3221489 http://www.medworm.com/index.php?rid=3221488&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20107159%26dopt%3DAbstract Conclusions Individual HDAC inihibitor treatment has specific effects on cell fate decisions during myeloid development. These data provide novel insights in the effects of HDAC inhibitors on regulation of normal hematopoiesis, which is of importance when considering utilizing these compounds for the treatment of myeloid malignancies and bone marrow failure syndromes. PMID: 20107159 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3221488 Wed, 27 Jan 2010 00:00:00 +0100 3221488 http://www.medworm.com/index.php?rid=3190107&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20081055%26dopt%3DAbstract Conclusions High dose RHAMM-R3 peptide vaccination induced immunological responses and positive clinical effects. Therefore, RHAMM constitutes a promising structure for further targeted immunotherapies in patients with different hematological malignancies. However, higher doses of peptide did not improve the frequency and intensity of immune responses in this trial. PMID: 20081055 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3190107 Fri, 15 Jan 2010 00:00:00 +0100 3190107 http://www.medworm.com/index.php?rid=3190106&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20081056%26dopt%3DAbstract Authors: Palandri F, Polverelli N, Ottaviani E, Castagnetti F, Baccarani M, Vianelli N PMID: 20081056 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3190106 Fri, 15 Jan 2010 00:00:00 +0100 3190106 http://www.medworm.com/index.php?rid=3190105&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20081057%26dopt%3DAbstract Conclusions These results indicate that HPC and HSC show different mobilization kinetics in response to FL, resulting in preferential mobilization of HPC at day 5, followed by HSC mobilization at day 10. PMID: 20081057 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3190105 Fri, 15 Jan 2010 00:00:00 +0100 3190105 http://www.medworm.com/index.php?rid=3190104&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20081058%26dopt%3DAbstract CONCLUSIONS Allogeneic SCT therefore yields a high rate of complete remissions and is potentially curative in poor-risk WM. PMID: 20081058 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3190104 Fri, 15 Jan 2010 00:00:00 +0100 3190104 http://www.medworm.com/index.php?rid=3190103&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20081059%26dopt%3DAbstract Authors: Caraux A, Klein B, Paiva B, Bret C, Schmitz A, Fuhler GM, Bos NA, Johnsen HE, Orfao A, Perez-Andres M, Generation of B and plasma cells (PC) involves several organs with a necessary cell trafficking between them. A detailed phenotypic characterization of four circulating B-cell subsets - immature-, naïve-, memory- B-lymphocytes and PC - of 106 healthy adults was realized by multiparametric flow cytometry. We show that CD10, CD27 and CD38 is the minimal combination of subsetting markers allowing unequivocal identification of immature (CD10(+)CD27(-)CD38(+), 6+/-6 cells/mul), naïve (CD10(-)CD27(-)CD38(-), 125+/-90 cells/mul), memory B-lymphocytes (CD10(-)CD27(+)CD38(-), 58+/-42 cells/mul), and PC (CD10(-)CD27(++)CD38(++), 2.1+/-2.1 cells/mul) within circulating CD19(+... Haematologica journals http://www.medworm.com/rss/comments.php?id=3190103 Fri, 15 Jan 2010 00:00:00 +0100 3190103 http://www.medworm.com/index.php?rid=3190102&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20081060%26dopt%3DAbstract Conclusions Our results suggest a new understanding of the contribution of endothelial cell activation to the pathogenesis of thrombosis in PNH. The terminal complement inhibitor, eculizumab, induced a significant and sustained decrease in the activation of both the plasma hemostatic system and the vascular endothelium, likely contributing to the protective effect of eculizumab on thrombosis in this setting. PMID: 20081060 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3190102 Fri, 15 Jan 2010 00:00:00 +0100 3190102 http://www.medworm.com/index.php?rid=3190101&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20081061%26dopt%3DAbstract Conclusions These findings are consistent with an important role of the membrane-proximal region of beta3 in modulating alphaIIbbeta3 clustering and lateral redistribution of membrane lipids. Since the beta3 mutant associated to thrombasthenic phenotype in a patient carrying one normal beta3 allele, the results support a dominant role of clustering in regulating integrin alphaIIbbeta3 functions in vivo. PMID: 20081061 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3190101 Fri, 15 Jan 2010 00:00:00 +0100 3190101 http://www.medworm.com/index.php?rid=3156881&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20053867%26dopt%3DAbstract Authors: Dufour C, Cappelli B, Calvillo M, Fioredda F, Tonelli R, Crocchiolo R PMID: 20053867 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3156881 Wed, 06 Jan 2010 00:00:00 +0100 3156881 http://www.medworm.com/index.php?rid=3156880&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20053868%26dopt%3DAbstract Conclusions Long-term cell growth induced similar gene expression changes in mesenchymal stromal cells independent of isolation and expansion conditions. In advance of therapeutical application, this panel of genes might offer a practicable approach to assess mesenchymal stromal cell quality with regard to the state of replicative senescence. PMID: 20053868 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3156880 Wed, 06 Jan 2010 00:00:00 +0100 3156880 http://www.medworm.com/index.php?rid=3156879&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20053869%26dopt%3DAbstract Conclusions This combination showed anti-tumor activity with favourable tolerability. The maximum tolerated dose of Defibrotide was fixed at 7,2 g p.o. on day 1-4 followed by 4,8 g p.o. on days 5-35. Further trials are needed to confirm the role of this regimen and to evaluate the combination of defibrotide with new drugs. PMID: 20053869 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3156879 Wed, 06 Jan 2010 00:00:00 +0100 3156879 http://www.medworm.com/index.php?rid=3156878&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20053870%26dopt%3DAbstract Authors: Kristinsson SY, Landgren O, Samuelsson J, Björkholm M, Goldin LR The causes of myeloproliferative neoplasm (MPN) are unknown. We conducted a large population-based study including 11,039 MPN patients and 43,550 matched controls with the aim to assess the associations between a personal history of a broad span of autoimmune diseases and subsequent risk of MPN. We found a prior history of any autoimmune disease to be associated with a significantly increased risk of MPNs (odds ratio (OR)=1.2; 95% confidence interval (CI) 1.0-1.3; p= 0.021). Specifically, we found an increased risk of MPNs associated with a prior immune thrombocytopenic purpura (2.9; 1.7-7.2), Crohn's disease (1.8; 1.1-3.0), polymyalgia rheumatica (1.7; 1.2-2.5), giant cell arteritis (5.9; 2.4-14.4), Reiter'... Haematologica journals http://www.medworm.com/rss/comments.php?id=3156878 Wed, 06 Jan 2010 00:00:00 +0100 3156878 http://www.medworm.com/index.php?rid=3156877&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20053871%26dopt%3DAbstract Conclusion Because of the low incidence of CTEPH after PE and the very low yield of the echocardiography based screening program, wide scale implementation of prolonged follow-up including echocardiography of all patients with PE to detect CTEPH seems not warranted. PMID: 20053871 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3156877 Wed, 06 Jan 2010 00:00:00 +0100 3156877 http://www.medworm.com/index.php?rid=3101454&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20015871%26dopt%3DAbstract Conclusion Only VDR 5'-end (Cdx-2/GATA) haplotype 3 was identified as protective factor against excessive fat gain and as a risk factor for lower lumbar spine BMD during treatment. Carrying ESR1 (PvuII/XbaI) haplotype 3 negatively influenced recovery of lean body mass after pediatric ALL treatment. PMID: 20015871 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3101454 Wed, 16 Dec 2009 00:00:00 +0100 3101454 http://www.medworm.com/index.php?rid=3101453&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20015872%26dopt%3DAbstract Authors: Zhao M, Kanegane H, Ouchi K, Imamura T, Latour S, Miyawaki T PMID: 20015872 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3101453 Wed, 16 Dec 2009 00:00:00 +0100 3101453 http://www.medworm.com/index.php?rid=3101452&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20015873%26dopt%3DAbstract CONCLUSIONS: ICAM-4/ alpha(V)beta(3) and CD36/thrombospondin interactions might contribute to the abnormally high adhesiveness of SAD red cells. The SAD mouse is a valuable animal model for investigating adhesion processes of sickle cell disease. PMID: 20015873 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3101452 Wed, 16 Dec 2009 00:00:00 +0100 3101452 http://www.medworm.com/index.php?rid=3101451&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20015874%26dopt%3DAbstract CONCLUSIONS: We show for the first time that myelin P0 is naturally processed in IgM MGUS B cells, acting as aberrant antigen-presenting cells in activation of patients T helper cells. Our findings cast new light on the important role of autoreactive P0-specific B cells in the induction of the pathogenic T cell responses found in nerve lesions of MGUS patients with peripheral neuropathy. PMID: 20015874 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3101451 Wed, 16 Dec 2009 00:00:00 +0100 3101451 http://www.medworm.com/index.php?rid=3101450&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20015875%26dopt%3DAbstract Authors: Breccia M, Latagliata R, Cannella L, Minotti C, Meloni G, Lo-Coco F PMID: 20015875 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3101450 Wed, 16 Dec 2009 00:00:00 +0100 3101450 http://www.medworm.com/index.php?rid=3101449&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20015876%26dopt%3DAbstract Authors: Herbst C, Bauer K, Kreuzer KA PMID: 20015876 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3101449 Wed, 16 Dec 2009 00:00:00 +0100 3101449 http://www.medworm.com/index.php?rid=3101448&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20015877%26dopt%3DAbstract Conclusions These findings reveal the convergence of STAT3 and ERK1/2 signaling pathways activated by NPM-ALK, in mediating the regulation of C/EBPbeta expression, a transcription factor central to NPM-ALK transformation. PMID: 20015877 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3101448 Wed, 16 Dec 2009 00:00:00 +0100 3101448 http://www.medworm.com/index.php?rid=3101447&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20015878%26dopt%3DAbstract Conclusions HIF-2 is a novel regulator of CXCL12 expression in MM PCs and a major contributor to MM PC-induced angiogenesis. Targeting the hypoxic niche, and more specifically HIF-2, may represent a viable strategy to inhibit MM angiogenesis and disease progression. PMID: 20015878 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3101447 Wed, 16 Dec 2009 00:00:00 +0100 3101447 http://www.medworm.com/index.php?rid=3101446&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20015879%26dopt%3DAbstract Conclusions These results suggest that a cross-talk between the mutated band 3 and other transporters might increase the cation permeability in cryohydrocytosis. PMID: 20015879 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3101446 Wed, 16 Dec 2009 00:00:00 +0100 3101446 http://www.medworm.com/index.php?rid=3101445&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20015880%26dopt%3DAbstract Authors: Silva A, Jotta PY, Silveira AB, Ribeiro D, Brandalise SR, Yunes JA, Barata JT T-cell acute lymphoblastic leukemia (T-ALL) patients frequently display NOTCH1 activating mutations and Notch can transcriptionally downregulate the tumor suppressor PTEN. However, it is not clear whether NOTCH1 mutations associate with decreased PTEN expression in primary T-ALL. Here, we compared patients with or without NOTCH1 mutations and report that the former presented higher MYC transcript levels and decreased PTEN mRNAexpression. We recently showed that T-ALL cells frequently display CK2-mediated PTEN phosphorylation, resulting in PTEN protein stabilization and concomitant functional inactivation. Accordingly, the T-ALL samples analyzed, irrespectively of their NOTCH1 mutational status, expre... Haematologica journals http://www.medworm.com/rss/comments.php?id=3101445 Wed, 16 Dec 2009 00:00:00 +0100 3101445 http://www.medworm.com/index.php?rid=3101444&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20015881%26dopt%3DAbstract Authors: Pidala J, Anasetti C Allogeneic hematopoietic cell transplantation provides effective control of hematopoietic malignancies, but with an associated risk of graft-versus-host disease (GVHD) related morbidity and mortality. Several advances in hematopoietic cell transplantation including high resolution HLA typing, development of reduced intensity conditioning regimens, infectious prophylaxis and treatment, and novel immunosuppressive agent have resulted in improved outcomes and improved access to transplantation, but GVHD remains a major obstacle. This clinicopathologic syndrome, mediated by donor alloreactive T cells, occurs often despite prophylactic immunosuppressive therapy. Regulatory T cells, a suppressive subset of the T cell repertoire, may offer promise as a novel cell... Haematologica journals http://www.medworm.com/rss/comments.php?id=3101444 Wed, 16 Dec 2009 00:00:00 +0100 3101444 http://www.medworm.com/index.php?rid=3101443&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20015882%26dopt%3DAbstract In conclusion, novel genomic aberrations were identified in our study, in particular in patients with myelofibrosis. Further analyses on single-gene level are necessary to uncover the mechanisms that are involved in the pathogenesis of myeloproliferative neoplasms. PMID: 20015882 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3101443 Wed, 16 Dec 2009 00:00:00 +0100 3101443 http://www.medworm.com/index.php?rid=3101442&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20015883%26dopt%3DAbstract Authors: Mattsson G, Turner SH, Cordell J, Ferguson DJ, Schuh A, Grimwade LF, Bench AJ, Weinberg OK, Marafioti T, George TI, Arber DA, Erber WN, Mason DY Mutations in the C-terminal region of nucleophosmin in acute myeloid leukemia (AML) result in aberrant cytoplasmic nucleophosmin (cNPM) in leukemic blast cells which is detectable by immunocytochemistry in bone marrow trephine (BMT) biopsy sections. We tested whether cNPM is detectable by immunocytochemistry in air-dried smears of AML with nucleophosmin1 (NPM1) mutations. An immunoalkaline phosphatase method was developed using the OCI-AML3 cell line, known to have mutated NPM1, and assessed on blood and marrow smears of 60 AML cases. NPM was detectable in all blast cell nucleoli and cNPM in 21/31 of NPM1 mutated and 15/29 wildtype ca... Haematologica journals http://www.medworm.com/rss/comments.php?id=3101442 Wed, 16 Dec 2009 00:00:00 +0100 3101442 http://www.medworm.com/index.php?rid=3101441&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20015884%26dopt%3DAbstract Conclusions Whereas BCR-ABL KD mutations may confer more specific resistance to nilotinib, which will predominantly affect response rates, the presence of ACA may reflect genetic instability and therefore intrinsic aggressiveness of the disease which will be less amenable to subsequent alternative treatments and thus negatively affect overal survival. Conventional cytogenetic analyses remain mandatory during follow-up of patients with CML under tyrosine kinase inhibito therapy. PMID: 20015884 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3101441 Wed, 16 Dec 2009 00:00:00 +0100 3101441 http://www.medworm.com/index.php?rid=3101440&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20015885%26dopt%3DAbstract Conclusions CT antigens such as MAGE-C1/CT7 and MAGE-A3 play an important role in promoting survival of myeloma cells and clonogenic precursors by reducing the rate of spontaneous and chemotherapy-induced apoptosis and might therefore represent attractive targets for novel myeloma-specific therapies. PMID: 20015885 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3101440 Wed, 16 Dec 2009 00:00:00 +0100 3101440 http://www.medworm.com/index.php?rid=3101439&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20015886%26dopt%3DAbstract Conclusions The addition of intravenous cytarabine to imatinib as upfront therapy for chronic myeloid leukemia patients is associated with a high rate of complete molecular responses. Currently, a randomized trial is being performed, which will definitely assess the value of the addition of cytarabine to imatinib. This study was registered at www.clinicaltrials.gov identifier: NCT00028847. PMID: 20015886 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3101439 Wed, 16 Dec 2009 00:00:00 +0100 3101439 http://www.medworm.com/index.php?rid=3101438&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20015887%26dopt%3DAbstract Conclusion This study confirms the existence of CD5 positive SMZL cases that appear closely related to classical SMZL. Whether they constitute or not a true subset requires obviously the study of more cases. PMID: 20015887 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3101438 Wed, 16 Dec 2009 00:00:00 +0100 3101438 http://www.medworm.com/index.php?rid=3101437&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20015888%26dopt%3DAbstract Conclusions This is the first investigation on the molecular genetics of FHL in Korea. The data showed that UNC13D is the predominant causative gene in the Korean population. The identification of mutations missed by conventional sequencing would better delineate the mutation spectrum and to establish the optimal molecular diagnostic strategy for FHL in Korea, which might need an RNA-based screening strategy. PMID: 20015888 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3101437 Wed, 16 Dec 2009 00:00:00 +0100 3101437 http://www.medworm.com/index.php?rid=3101436&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20015889%26dopt%3DAbstract Conclusion These findings suggest that NCAM molecule expressed on the FMS/PA6-P cells plays a crucial role in the human hemopoiesis-supporting ability of the cell line. PMID: 20015889 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3101436 Wed, 16 Dec 2009 00:00:00 +0100 3101436 http://www.medworm.com/index.php?rid=3101435&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20015890%26dopt%3DAbstract Conclusion ! aryotype is now assessed in most MDS, and EPO level is generally <500 IU/L while patients <65 years may have more aggressive disease. Apart from ESAs, and, in HR MDS, hypomethylating agents, specific treatments are used in a minority of MDS and RBC transfusions still represent the major reason for hospital admission. PMID: 20015890 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3101435 Wed, 16 Dec 2009 00:00:00 +0100 3101435 http://www.medworm.com/index.php?rid=3101434&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20015891%26dopt%3DAbstract Conclusions These results suggest the failure of thalassemic erythroblasts to cope with cellular stress caused by an impaired UPR function as a result of high Ca(2+) levels may exacerbate thalassemic cell death during erythropoiesis. PMID: 20015891 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3101434 Wed, 16 Dec 2009 00:00:00 +0100 3101434 http://www.medworm.com/index.php?rid=3101433&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20015892%26dopt%3DAbstract We report on a case with CMMRD caused by a novel MSH6 mutation leading to a T-cell lymphoma and colonic adenocarcinoma at age 6 and 13, respectively. Reviewing the literature on hematological malignancies in CMMRD displayed that in almost half of the 47 known CMMRD families at least one individual is affected by a hematological malignancy, predominantly T-cell lymphomas. However, diagnosing CMMRD may be difficult when the first child is affected by leukemia/lymphoma, but identification of the causative germline mutation is of vital importance: (i) to identify relatives at risk and exclude an increased risk in non-mutation carriers, (ii) to prevent hematopoietic stem cell transplantation from sibling donors also carrying a biallelic germline mutation, and (iii) to implement effective survei... Haematologica journals http://www.medworm.com/rss/comments.php?id=3101433 Wed, 16 Dec 2009 00:00:00 +0100 3101433 http://www.medworm.com/index.php?rid=3101432&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20015893%26dopt%3DAbstract Conclusion This study allowed to define the most frequent mutations in CDA II patients. Moreover, correlation between the mutations and various biological parameters suggested that the association of one missense mutation and one nonsense mutation was significantly more deleterious that the association of two missense mutations. However, there remained an overlapping between the two categories. PMID: 20015893 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3101432 Wed, 16 Dec 2009 00:00:00 +0100 3101432 http://www.medworm.com/index.php?rid=3101431&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20015894%26dopt%3DAbstract We report that two thirds of somatic events involved loss of heterozygosity (LOH) at the NF1 locus, predominantly caused by segmental uniparental disomy of large parts of chromosome arm 17q. One third of leukemias showed compound-heterozygous NF1-inactivating mutations. A minority of cases exhibited somatic interstitial deletions. The findings reinforce the emerging role of somatic mitotic recombination as a leukemogenic mechanism. In addition, they support that biallelic NF1 inactivation in hematopoietic progenitor cells is required for transformation to JMML in children with NF-1. PMID: 20015894 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3101431 Wed, 16 Dec 2009 00:00:00 +0100 3101431 http://www.medworm.com/index.php?rid=3101466&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20007134%26dopt%3DAbstract HAMP promoter mutation nc.-153C>T in non p.C282Y homozygous patients with iron overload. Haematologica. 2009 Dec 8; Authors: Aguilar-Martinez P, Giansily-Blaizot M, Bismuth M, Cunat S, Igual H, Schved JF PMID: 20007134 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3101466 Tue, 08 Dec 2009 00:00:00 +0100 3101466 http://www.medworm.com/index.php?rid=3101465&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20007135%26dopt%3DAbstract Conclusions This study suggests that antifungal prophylaxis voriconazole could be useful in acute leukemia patients undergoing first remission-induction chemotherapy where there is a high-risk of invasive aspergillosis. PMID: 20007135 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3101465 Tue, 08 Dec 2009 00:00:00 +0100 3101465 http://www.medworm.com/index.php?rid=3101464&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20007136%26dopt%3DAbstract Authors: Le Gac G, Congiu R, Gourlaouen I, Cau M, Férec C, Melis MA We recently characterized an Alu-mediated recombination causing the loss of the complete HFE gene sequence. Here, we describe the case of a novel homozygous patient. We further show that HFE deletion results from a founder effect, and that it represents the common cause of haemochromatosis in Sardinia. PMID: 20007136 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3101464 Tue, 08 Dec 2009 00:00:00 +0100 3101464 http://www.medworm.com/index.php?rid=3101463&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20007137%26dopt%3DAbstract Conclusion TKI therapy can cure CML, although it may have to be prolonged. The depth of response increases with time in the vast majority of patients. These results illustrate the relevance of stochastic effects on the dynamics of acquired HSC disorders and have direct impact on other HSC derived diseases. PMID: 20007137 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3101463 Tue, 08 Dec 2009 00:00:00 +0100 3101463 http://www.medworm.com/index.php?rid=3101462&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20007138%26dopt%3DAbstract Conclusions Iron-overload complication rates of French thalassemia major patients appeared similar to those reported in other non-endemic developed countries. There were no significant differences of height and parenthood rates between the major and the intermedia forms of the disease, underlining the progress in clinical care. Future developments will focus on mortality and morbidity under oral chelation treatment. PMID: 20007138 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3101462 Tue, 08 Dec 2009 00:00:00 +0100 3101462 http://www.medworm.com/index.php?rid=3101461&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20007139%26dopt%3DAbstract Conclusion Our current data indicate a critical role for IGF-1 autocriny in constitutive PI3K/Akt activation in primary AML cells and provide a strong rationale for targeting IGF-1R as a potential new therapy for this disease. PMID: 20007139 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3101461 Tue, 08 Dec 2009 00:00:00 +0100 3101461 http://www.medworm.com/index.php?rid=3101460&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20007140%26dopt%3DAbstract Conclusions The hemangioblast with lymphomyeloid potential is one of the precursors of definitive hematopoiesis in the mouse AGM region. Moreover, the regulatory role of IL-3 is extended to the dual-potential hemangioblast concerning both number and capacity. PMID: 20007140 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3101460 Tue, 08 Dec 2009 00:00:00 +0100 3101460 http://www.medworm.com/index.php?rid=3101459&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20007141%26dopt%3DAbstract We report here a new erythrocytosis-associated mutation, p.Asp539Glu, in the HIF2A gene. Similar to all reported cases, the affected residue is in close vicinity and C-terminal to the primary hydroxylation site in HIF-2alpha, Pro531. This mutation, however, is notable in producing a rather subtle amino acid substitution. Nonetheless, we find that this mutation compromises binding of HIF-2alpha to both PHD2 and VHL, and we propose that this mutation is the cause of erythrocytosis in this individual. PMID: 20007141 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3101459 Tue, 08 Dec 2009 00:00:00 +0100 3101459 http://www.medworm.com/index.php?rid=3101458&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20007142%26dopt%3DAbstract Authors: Mäkelburg AB, Veeger NJ, Middeldorp S, Hamulyák K, Prins MH, Büller HR, Lijfering WM The term factor V Leiden (FVL) paradox is used to describe the different risk of deep-vein-thrombosis (DVT) and pulmonary embolism (PE) that has been found in carriers of FVL. In a thrombophilic family-cohort, we estimated differences in absolute risks of DVT and PE for various thrombophilic defects. Of 2054 relatives, 1131 were female, 41 had PE and 126 DVT. Annual incidence for DVT in non-carriers of FVL was 0.19% (95%CI, 0.16-0.23), and 0.41% (95%CI, 0.28-0.58) in carriers; relative risk (RR) 2.1 (95%CI, 1.4-3.2). For PE these incidences were similar in carriers and non-carriers 0.07%, respectively; RR 1.0 (95% CI, 0.4-2.5). When co-inheritance of other thrombophilic defects ... Haematologica journals http://www.medworm.com/rss/comments.php?id=3101458 Tue, 08 Dec 2009 00:00:00 +0100 3101458 http://www.medworm.com/index.php?rid=3101457&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20007143%26dopt%3DAbstract Conclusions The mEBMT was prognostic in our patient cohort with predominant influence of disease stage, whereas a trend but no significant prognostic value was observed for the HCT-CI. PMID: 20007143 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3101457 Tue, 08 Dec 2009 00:00:00 +0100 3101457 http://www.medworm.com/index.php?rid=3101456&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20007144%26dopt%3DAbstract Authors: Santarone S, Bacigalupo A, Risitano AM, Tagliaferri E, Di Bartolomeo E, Iori AP, Rambaldi A, Angelucci E, Spagnoli A, Papineschi F, Tamiazzo S, Di Nicola M, Di Bartolomeo P Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal disorder of the haemopoietic stem cells for which the only curative treatment is allogeneic haematopoietic stem cell transplantation (HSCT). The aim of this retrospective study was to assess the long-term clinical and haematological results in 26 PNH patients who received HSCT in Italy between 1988 and 2006. The patients were aged 22 to 60 years (median, 32 years). Twenty-three donors were HLA-identical (22 siblings and 1 unrelated) and 3 were HLA-mismatched (2 related and 1 unrelated). Fifteen patients received a myeloablative conditioning (MA... Haematologica journals http://www.medworm.com/rss/comments.php?id=3101456 Tue, 08 Dec 2009 00:00:00 +0100 3101456 http://www.medworm.com/index.php?rid=3101455&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20007145%26dopt%3DAbstract The -582A>G variant of the HAMP promoter is not associated with high serum ferritin levels in normal subjects. Haematologica. 2009 Dec 8; Authors: Bruno F, Bonalumi S, Camaschella C, Ferrari M, Cremonesi L PMID: 20007145 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3101455 Tue, 08 Dec 2009 00:00:00 +0100 3101455 http://www.medworm.com/index.php?rid=3076403&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19996112%26dopt%3DAbstract Authors: Bergamaschi G, Villani L PMID: 19996112 [PubMed - in process] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3076403 Tue, 01 Dec 2009 00:00:00 +0100 3076403 http://www.medworm.com/index.php?rid=3076402&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19996113%26dopt%3DAbstract Authors: Reiter A, Invernizzi R, Cross NC, Cazzola M PMID: 19996113 [PubMed - in process] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3076402 Tue, 01 Dec 2009 00:00:00 +0100 3076402 http://www.medworm.com/index.php?rid=3076401&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19996114%26dopt%3DAbstract Authors: Cools J, Vandenberghe P PMID: 19996114 [PubMed - in process] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3076401 Tue, 01 Dec 2009 00:00:00 +0100 3076401 http://www.medworm.com/index.php?rid=3076400&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19996115%26dopt%3DAbstract Authors: Kyle RA, Kumar S PMID: 19996115 [PubMed - in process] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3076400 Tue, 01 Dec 2009 00:00:00 +0100 3076400 http://www.medworm.com/index.php?rid=3076399&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19996116%26dopt%3DAbstract Authors: Drewniak A, Kuijpers TW PMID: 19996116 [PubMed - in process] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3076399 Tue, 01 Dec 2009 00:00:00 +0100 3076399 http://www.medworm.com/index.php?rid=3076398&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19996117%26dopt%3DAbstract Conclusions Granulocyte transfusions may have an adjunctive role in severe infections in patients with severe aplastic anemia. HLA alloimmunization is not an absolute contraindication to granulocyte therapy. PMID: 19996117 [PubMed - in process] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3076398 Tue, 01 Dec 2009 00:00:00 +0100 3076398 http://www.medworm.com/index.php?rid=3076397&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19996118%26dopt%3DAbstract Conclusions These results indicate that the presence and time of occurrence of Delta13 depends on the presence of specific concurrent abnormalities. The observation that Delta13 was extremely rare in monoclonal gammopathy of undetermined significance and smoldering multiple myeloma with translocations directly involving cyclin D genes (CCND1 and CCND3) suggest a possible role of Delta13 in the progression of the disease specifically in these genetic sub-groups. (clinicaltrials.gov identifier: ISRCTN 68454111; UKCRN ID 1176). PMID: 19996118 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3076397 Tue, 01 Dec 2009 00:00:00 +0100 3076397 http://www.medworm.com/index.php?rid=3076396&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19996119%26dopt%3DAbstract Authors: Kroot JJ, Kemna EH, Bansal SS, Busbridge M, Campostrini N, Girelli D, Hider RC, Koliaraki V, Mamalaki A, Olbina G, Tomosugi N, Tselepis C, Ward DG, Ganz T, Hendriks JC, Swinkels DW The recently discovered iron regulatory peptide hormone hepcidin holds promise as a novel biomarker in iron metabolism disorders. To date, various mass spectrometry and immunochemical methods have been developed for its quantification in plasma and urine. Differences in methodology and analytical performance hinder the comparability of data. As a first step towards method harmonization, several hepcidin assays were compared. Worldwide eight laboratories participated in a urinary and plasma round robin in which hepcidin was analyzed. For both urine and plasma: (i) the absolute hepcidin concentrations... Haematologica journals http://www.medworm.com/rss/comments.php?id=3076396 Tue, 01 Dec 2009 00:00:00 +0100 3076396 http://www.medworm.com/index.php?rid=3076395&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19996120%26dopt%3DAbstract Authors: Zheng C, Wu J, Liu X, Ding K, Cai X, Zhu W PMID: 19996120 [PubMed - in process] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3076395 Tue, 01 Dec 2009 00:00:00 +0100 3076395 http://www.medworm.com/index.php?rid=3076394&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19996121%26dopt%3DAbstract Authors: Wang J, Xu X PMID: 19996121 [PubMed - in process] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3076394 Tue, 01 Dec 2009 00:00:00 +0100 3076394 http://www.medworm.com/index.php?rid=3076393&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19996122%26dopt%3DAbstract Authors: Leytin V, Mutlu A, Mykhaylov S, Allen DJ, Gyulkhandanyan AV, Freedman J PMID: 19996122 [PubMed - in process] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3076393 Tue, 01 Dec 2009 00:00:00 +0100 3076393 http://www.medworm.com/index.php?rid=3052948&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19951967%26dopt%3DAbstract Authors: Domingo E, Moreno C, Sánchez-Ibarrola A, Panizo C, Páramo JA, Merino J PMID: 19951967 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3052948 Mon, 30 Nov 2009 00:00:00 +0100 3052948 http://www.medworm.com/index.php?rid=3052945&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19951968%26dopt%3DAbstract Conclusions Disease stage, presentation karyotype and post-transplant CsA exposure are important predictors of outcome in patients undergoing a T cell depleted RIC allograft for AML. These data confirm the presence of a potent GVL effect after a T cell depleted RIC allograft in AML and identify CsA exposure as a manipulable determinant of outcome in this setting. PMID: 19951968 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3052945 Mon, 30 Nov 2009 00:00:00 +0100 3052945 http://www.medworm.com/index.php?rid=3052944&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19951969%26dopt%3DAbstract Conclusions The strict follow-up and detailed guidelines for management of parturition have produced a very low rate of immediate and late bleeding complications. Desmopressin was effective and safe in preventing significant bleeding at delivery in most of these patients. PMID: 19951969 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3052944 Mon, 30 Nov 2009 00:00:00 +0100 3052944 http://www.medworm.com/index.php?rid=3052943&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19951970%26dopt%3DAbstract Authors: Giannini S, Cecchetti L, Mezzasoma AM, Gresele P Platelet-type von Willebrand disease (PT-VWD) is a rare autosomal dominant bleeding disorder due to a mutation in the gene encoding for platelet glycoprotein Ib (GPIb ) resulting in enhanced affinity for von Willebrand factor (VWF). PT-VWD is often mistakenly diagnosed as type 2B VWD for the similarities between these two conditions. We have characterized a new case of PT-VWD and have evaluated the usefulness of a flow cytometric assay in the differential diagnosis between PT-VWD (n=1) and type 2B VWD (n=4). The flow cytometric assay was able to highlight the increased affinity of VWF for GPIb as much as did RIPA and to differentiate the two diseases through mixing tests. Genetic analysis revealed a heterozygous point mutation i... Haematologica journals http://www.medworm.com/rss/comments.php?id=3052943 Mon, 30 Nov 2009 00:00:00 +0100 3052943 http://www.medworm.com/index.php?rid=3052942&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19951971%26dopt%3DAbstract Authors: Park S, Chapuis N, Tamburini J, Bardet V, Cornillet-Lefebvre P, Willems L, Green A, Mayeux P, Lacombe C, Bouscary D The PI3K/AKT and mTOR signalling pathways are activated in acute myeloid leukemia (AML), including in the more immature leukemic populations. Constitutive PI3K activation is detectable in 50% of AML samples whereas mTORC1 is activated in all cases of this disease. In leukemic cells, the PI3K activity relates to the expression of the p110 isoform of class IA PI3K. Constitutive PI3K activation is the result of autocrine IGF-1/IGF-1R signalling in 70% of AML samples but specific inhibition of this pathway does not induce apoptosis. Specific inhibition of PI3K/AKT or mTORC1 alone in vitro has anti-leukemic effects which are essentially exerted via the suppression of ... Haematologica journals http://www.medworm.com/rss/comments.php?id=3052942 Mon, 30 Nov 2009 00:00:00 +0100 3052942 http://www.medworm.com/index.php?rid=3052941&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19951972%26dopt%3DAbstract In conclusion, adding radiotherapy to chemotherapy improves tumor control and OS in patients with early stage Hodgkin lymphoma. PMID: 19951972 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3052941 Mon, 30 Nov 2009 00:00:00 +0100 3052941 http://www.medworm.com/index.php?rid=3052940&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19951973%26dopt%3DAbstract Authors: Joly P, Lacan P, Labalme A, Bonhomme E, Sanlaville D, Francina A PMID: 19951973 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3052940 Mon, 30 Nov 2009 00:00:00 +0100 3052940 http://www.medworm.com/index.php?rid=3052939&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19951974%26dopt%3DAbstract Authors: Wilson K, Case M, Minto L, Bailey S, Bown N, Jesson J, Lawson S, Vormoor J, Irving J Flow cytometric minimal residual disease (MRD) monitoring could become more powerful if directed towards the disease-maintaining leukaemic stem cell (LSC) compartment. Using a cohort of 48 children with B lineage acute lymphoblastic leukamia (ALL), we sought the newly proposed candidate-LSC population, CD34(+)CD38(low)CD19(+), at presentation and in end of induction bone marrow samples. We identified the candidate LSC population in 60% of diagnostic samples and its presence correlated with expression of CD38, relative to that of normal B cell progenitors. In addition, the candidate LSC was not detectable in all MRD positive samples. The absence of the population in 40% of diagnostic and 40% of... Haematologica journals http://www.medworm.com/rss/comments.php?id=3052939 Mon, 30 Nov 2009 00:00:00 +0100 3052939 http://www.medworm.com/index.php?rid=3052938&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19951975%26dopt%3DAbstract Conclusions In these cases the sequence of events between the insect bites, and the occurrence of both skin lesions and satellite lymphadenopathy suggest a direct relationship between the bite and the presentation with ALCL. We postulate that insect bite associated-antigens could result in an influx of T lymphocytes, some bearing the t(2;5). The subsequent r elease of cytokines at the site of bite could act as a second hit to elicit the activation of the latter cells, which then would express the oncogenic NPM-ALK protein and undergo an uncontrolled proliferation. PMID: 19951975 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3052938 Mon, 30 Nov 2009 00:00:00 +0100 3052938 http://www.medworm.com/index.php?rid=3052937&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19951976%26dopt%3DAbstract Conclusions Gene expression markers are suitable for screening but not as surrogate for genetic risk factors. While many individual markers may be associated with outcome, only few are of independent prognostic significance. Genetic prognostic factors cannot be substituted by the expression markers. PMID: 19951976 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3052937 Mon, 30 Nov 2009 00:00:00 +0100 3052937 http://www.medworm.com/index.php?rid=3052936&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19951977%26dopt%3DAbstract Authors: Karow A, Flotho C, Schneider M, Fliegauf M, Niemeyer CM, PMID: 19951977 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3052936 Mon, 30 Nov 2009 00:00:00 +0100 3052936 http://www.medworm.com/index.php?rid=3052934&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19951978%26dopt%3DAbstract Conclusions The potent activity, together with the exclusive mechanistic profile, provides the rationale for the clinical evaluation of these drug combinations in MM. PMID: 19951978 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3052934 Mon, 30 Nov 2009 00:00:00 +0100 3052934 http://www.medworm.com/index.php?rid=3052931&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19951979%26dopt%3DAbstract Conclusions Analysis of this large, prospectively collected data set confirms the response to chelation therapy across various anemias, supporting initial deferasirox doses based on transfusional iron intake, with subsequent dose titration guided by trends in serum ferritin and safety markers. PMID: 19951979 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=3052931 Mon, 30 Nov 2009 00:00:00 +0100 3052931 http://www.medworm.com/index.php?rid=2987498&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19903673%26dopt%3DAbstract Conclusions The results of this study extend the utility of a new prognostic index for predicting TFT in a large sample series of community-based patients with early CLL stage at presentation. Finally, our effort to develop a revised scoring method meets the need to dissect Binet stage A patients into different prognostic groups suitable for devising individualized and tailored follow-up during the treatment-free period. PMID: 19903673 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=2987498 Tue, 10 Nov 2009 00:00:00 +0100 2987498 http://www.medworm.com/index.php?rid=2987497&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19903674%26dopt%3DAbstract Conclusions However, neither ACA overall nor any specific abnormality were identified as independent risk factor for relapse in multivariate analysis. The lack of independent prognostic value of ACA in APL does not support the use of alternative therapeutic strategies based on this cytogenetic finding. PMID: 19903674 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=2987497 Tue, 10 Nov 2009 00:00:00 +0100 2987497 http://www.medworm.com/index.php?rid=2987496&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19903675%26dopt%3DAbstract Conclusions These data emphasize the relevance of CLIP expression on leukemic blasts and the potential of CLIP as a target for immunomodulatory strategies to enhance HLA class II antigen presentation and CD4(+) T cell reactivity in AML. PMID: 19903675 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=2987496 Tue, 10 Nov 2009 00:00:00 +0100 2987496 http://www.medworm.com/index.php?rid=2987495&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19903676%26dopt%3DAbstract Conclusions Provided that a multidisciplinary team is available, pregnancy is possible, safe and usually has a favorable outcome in patients with thalassemia. In women with hypogonadotropic hypogonadism, gonadal function is usually intact and fertility is usually retrievable. PMID: 19903676 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=2987495 Tue, 10 Nov 2009 00:00:00 +0100 2987495 http://www.medworm.com/index.php?rid=2987494&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19903677%26dopt%3DAbstract Conclusions IgA and IgG hypogammaglobulinemia is common in WM which persists despite therapeutic intervention and response. IgA and IgG hypogammaglobulinemia do not predict for recurrent infection risk in WM patients, though lower levels of serum IgA and IgG are associated with disease progression in WM patients on watch and wait. PMID: 19903677 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=2987494 Tue, 10 Nov 2009 00:00:00 +0100 2987494 http://www.medworm.com/index.php?rid=2987493&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19903678%26dopt%3DAbstract Conclusions Pre-transplantation transfusion history and serum ferritin have a significant prognostic value in MDS patients undergoing myeloablative allo-SCT, inducing a significant increase of NRM. These results indicate that transfusion history should be considered in transplantation decision-making in MDS. PMID: 19903678 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=2987493 Tue, 10 Nov 2009 00:00:00 +0100 2987493 http://www.medworm.com/index.php?rid=2987492&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19903679%26dopt%3DAbstract Authors: Flach J, Dicker F, Schnittger S, Kohlmann A, Haferlach T, Haferlach C PMID: 19903679 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=2987492 Tue, 10 Nov 2009 00:00:00 +0100 2987492 http://www.medworm.com/index.php?rid=2987491&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19903680%26dopt%3DAbstract Authors: Wermke M, von Bonin M, Gehrisch S, Siegert G, Ehninger G, Platzbecker U PMID: 19903680 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=2987491 Tue, 10 Nov 2009 00:00:00 +0100 2987491 http://www.medworm.com/index.php?rid=2987490&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19903681%26dopt%3DAbstract Authors: Brunvand MW, Bitter M PMID: 19903681 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=2987490 Tue, 10 Nov 2009 00:00:00 +0100 2987490 http://www.medworm.com/index.php?rid=2955638&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19880773%26dopt%3DAbstract Authors: Forsberg EC, Smith-Berdan S PMID: 19880773 [PubMed - in process] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=2955638 Sun, 01 Nov 2009 00:00:00 +0100 2955638 http://www.medworm.com/index.php?rid=2955637&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19880774%26dopt%3DAbstract Authors: Ataga KI PMID: 19880774 [PubMed - in process] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=2955637 Sun, 01 Nov 2009 00:00:00 +0100 2955637 http://www.medworm.com/index.php?rid=2955636&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19880775%26dopt%3DAbstract Authors: Cervantes F, Arellano-Rodrigo E, Alvarez-Larrán A PMID: 19880775 [PubMed - in process] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=2955636 Sun, 01 Nov 2009 00:00:00 +0100 2955636 http://www.medworm.com/index.php?rid=2955635&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19880776%26dopt%3DAbstract Authors: Pileri SA, Falini B PMID: 19880776 [PubMed - in process] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=2955635 Sun, 01 Nov 2009 00:00:00 +0100 2955635 http://www.medworm.com/index.php?rid=2955634&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19880777%26dopt%3DAbstract Conclusions The intracellular ABC transporter A3 is expressed in chronic myeloid leukemia progenitor cells and may contribute to intrinsic imatinib resistance by facilitating lysosomal sequestration in chronic myeloid leukemia cells. PMID: 19880777 [PubMed - in process] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=2955634 Sun, 01 Nov 2009 00:00:00 +0100 2955634 http://www.medworm.com/index.php?rid=2955633&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19880778%26dopt%3DAbstract Conclusions SOX11 mRNA and nuclear protein expression is a highly specific marker for both cyclin D1-positive and negative mantle cell lymphoma. PMID: 19880778 [PubMed - in process] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=2955633 Sun, 01 Nov 2009 00:00:00 +0100 2955633 http://www.medworm.com/index.php?rid=2955632&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19880779%26dopt%3DAbstract Conclusions In addition to mantle cell lymphoma, SOX11 is strongly expressed only in lymphoblastic malignancies and Burkitt's lymphomas. Its expression is independent of cyclin D1 (except for weak expression in hairy cell leukemias) and unlikely to be due to translocations in lymphoid neoplasia. PMID: 19880779 [PubMed - in process] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=2955632 Sun, 01 Nov 2009 00:00:00 +0100 2955632 http://www.medworm.com/index.php?rid=2955631&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19880780%26dopt%3DAbstract Conclusions The previously reported International Prognostic Index-independent prognostic value of stratification into germinal center/non-germinal center B-cell lymphoma using the expression pattern of CD10, BCL6, and IRF4 was not reproducible in our series. However, other markers and the morphological subtype appear to be of prognostic value. PMID: 19880780 [PubMed - as supplied by publisher] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=2955631 Sun, 01 Nov 2009 00:00:00 +0100 2955631 http://www.medworm.com/index.php?rid=2955630&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19880781%26dopt%3DAbstract Authors: Paiva B, Vidriales MB, Pérez JJ, Mateo G, Montalbán MA, Mateos MV, Bladé J, Lahuerta JJ, Orfao A, San Miguel JF Quantification of bone marrow plasma cells in multiple myeloma patients using conventional morphology is of limited prognostic value, while the merit of multiparameter flow cytometry immunophenotyping is still considered unproven. Here we compare the bone marrow plasma cell counts obtained by morphology and multiparameter flow cytometry and explore the potential prognostic impact of both techniques in 765 newly diagnosed, uniformly treated multiple myeloma patients. Although multiparameter flow cytometry generally yields lower plasma cell counts (median percentage of 11% vs. 40%, respectively; p<0.001), there is a significant positive correlation be... Haematologica journals http://www.medworm.com/rss/comments.php?id=2955630 Sun, 01 Nov 2009 00:00:00 +0100 2955630 http://www.medworm.com/index.php?rid=2955629&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19880782%26dopt%3DAbstract Authors: Quinn J, Von Klemperer K, Brooks R, Peebles D, Walker F, Cohen H The use of standard dose low molecular weight heparin (LMWH) to anticoagulate women with mechanical valves in pregnancy is associated with morbidity and mortality. We conducted a prospective audit of the use of adjusted dose high intensity LMWH in 12 pregnancies in 11 women with prosthetic heart valves. LMWH +/- low-dose aspirin was started at therapeutic-dose with monitoring of anti-Xa levels to achieve a target level of 1.0-1.2 IU/mL (0.8-1.2 in the first 3/12 pregnancies). This necessitated a mean increase in the dose of LMWH of 54.4% (SD+/-33.2) over initial dose. Eleven of 12 pregnancies resulted in live births, with one intrauterine fetal death at 37 weeks. One non-fatal valve thrombosis occurred at 26 week... Haematologica journals http://www.medworm.com/rss/comments.php?id=2955629 Sun, 01 Nov 2009 00:00:00 +0100 2955629 http://www.medworm.com/index.php?rid=2955628&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19880783%26dopt%3DAbstract Authors: Bornhäuser M, Oelschlaegel U, Platzbecker U, Bug G, Lutterbeck K, Kiehl MG, Schetelig J, Kiani A, Illmer T, Schaich M, Theuser C, Mohr B, Brendel C, Fauser AA, Klein S, Martin H, Ehninger G, Thiede C Analysis of donor chimerism is an important diagnostic tool to assess the risk of relapse after allogeneic stem cell transplantation, especially in patients lacking a specific marker suitable for monitoring of minimal residual disease. We prospectively investigated the predictive value of donor chimerism analyses in sorted CD34(+) peripheral blood cells in 90 patients with acute leukemia and myelodysplastic syndrome. The cumulative incidence of relapse after four years was significantly increased in cases with decreasing or incomplete CD34(+) donor chimerism (57% vs. 18%, p=0... Haematologica journals http://www.medworm.com/rss/comments.php?id=2955628 Sun, 01 Nov 2009 00:00:00 +0100 2955628 http://www.medworm.com/index.php?rid=2955627&cid=s_29484_19_f&fid=29484&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19880784%26dopt%3DAbstract Authors: Naresh KN PMID: 19880784 [PubMed - in process] (Source: Haematologica) Haematologica journals http://www.medworm.com/rss/comments.php?id=2955627 Sun, 01 Nov 2009 00:00:00 +0100 2955627