MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Hamostaseologie' source. Wed, 08 Feb 2012 17:42:01 +0100 http://www.medworm.com/index.php?rid=5607302&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22250808%26dopt%3DAbstract In conclusion, haemoctin SDH was effective, safe and well tolerated in long-term prophylaxis and treatment on demand. PMID: 22250808 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=5607302 Wed, 18 Jan 2012 05:00:00 +0100 5607302 http://www.medworm.com/index.php?rid=5607301&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22252568%26dopt%3DAbstract Authors: Riopel C, Bounameaux H Abstract The diagnosis of venous thromboembolism has evolved considerably with the development of standardized diagnostic algorithms that include clinical probability assessment, D-dimer measurement and the use of non-invasive imaging modalities such as compression ultrasonography and computed tomography angiography. The implementation of these strategies aims to improve resource allocation and patient outcome. The judicious use of these diagnostic tools requires a thorough knowledge of the appropriate clinical setting in which every test and strategy is efficient and can be used safely. For this purpose, D-dimer measurement and compression ultrasonography are complementary: the former is mainly used to exclude VTE in selected patients, while the lat... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=5607301 Sun, 01 Jan 2012 05:00:00 +0100 5607301 http://www.medworm.com/index.php?rid=5607300&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22252569%26dopt%3DAbstract Authors: Stephan F, Aarden LA, Zeerleder S Abstract Factor VII-activating protease (FSAP) is a serine protease in plasma that has a role in coagulation and fibrinolysis. FVII could be activated by purified FSAP in a tissue factor independent manner and pro-urokinase has been demonstrated to be a substrate for purified FSAP in-vitro. However, the physiological role of FSAP in haemostasis remains unclear. More recently FSAP is suggested to be involved in inflammation. It modulates vascular permeability directly and indirectly by the generation of bradykinin. Furthermore, FSAP is activated by dead cells induced by the inflammatory response and subsequently removes nucleosomes from apoptotic cells. FSAP activation can be detected in sepsis patients as well. However, whether FSAP activa... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=5607300 Sun, 01 Jan 2012 05:00:00 +0100 5607300 http://www.medworm.com/index.php?rid=5607303&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22109574%26dopt%3DAbstract Authors: Linnemann B, Lindhoff-Last E PMID: 22109574 [PubMed - indexed for MEDLINE] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=5607303 Thu, 01 Dec 2011 05:00:00 +0100 5607303 http://www.medworm.com/index.php?rid=5463721&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22124808%26dopt%3DAbstract Authors: Moser M, Bode C Abstract Atrial fibrillation is one of the most frequent reasons for therapeutic anticoagulation in everyday practice. Oral vitamin K antagonists such as Marcumar have been state of the art anticoagulants to prevent thrombembolic events in patients with atrial fibrillation and additional risk factors. But these drugs are accompanied by disadvantages such as increased bleeding risk and impaired quality of life caused by interactions with food or other medications as well as frequent controls of INRs. The new anticoagulants apixaban, rivaroxaban and dabigatran are direct antagonists of coagulation factors (FXa or FIIa) and demonstrate a promising risk/benefit profile in large clinical trials compared with vitamin K antagonists. Their approval for clinical use... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=5463721 Tue, 29 Nov 2011 05:00:00 +0100 5463721 http://www.medworm.com/index.php?rid=5463720&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22127528%26dopt%3DAbstract Authors: Halimeh S Abstract In women, von Willebrand disease (VWD) is the most common inherited bleeding disorder. Since VWD and other inherited bleeding disorders are autosomal disorders, they affect women and men. Menorrhagia, or heavy menstrual bleeding (HMB), is the most common symptom of women with bleeding disorder experience. Objectively, it is defined as bleeding that lasts for more than seven days or results in the loss of more than 80 ml of blood per menstrual cycle. The prevalence of menorrhagia in a woman with a bleeding disorder ranges from 32 to 100% in patients with VWD, from 5 to 98% in patients with a platelet dysfunction and from 35 to 70% in women with a rare factor deficiency. A detailed history and a careful physical exam are the first steps towards a diagnosis... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=5463720 Tue, 29 Nov 2011 05:00:00 +0100 5463720 http://www.medworm.com/index.php?rid=5428232&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22083512%26dopt%3DAbstract Authors: Stüssi G, Tsakiris DA Abstract Allogeneic and autologous hematopoietic stem cell transplantations are important therapeutic options for patients with hematologic disorders. Hemostatic complications are frequent after hematopoietic stem cell transplantation with a considerable morbidity and mortality. The incidence of bleedings and thrombosis is highest in the first few weeks after transplantation, but may also occur later. However, beyond the first year of transplantation only limited data are available. In long-term survivors the risk for premature atherosclerosis increases over time after allogeneic hematopoietic stem cell transplantation and it is higher than in the age-adjusted general population and in recipients of autologous transplantation. PMID: 22083512 [Pub... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=5428232 Tue, 15 Nov 2011 05:00:00 +0100 5428232 http://www.medworm.com/index.php?rid=5428233&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22071913%26dopt%3DAbstract Authors: Heuser M, Schlenk RF, Ganser A Abstract Genetic aberrations form the basis for diagnostic classification of patients with acute myeloid leukemia (AML) according to the World Health Organization (WHO) classification. Moreover, these aberrations predict response to induction chemotherapy, relapse-free survival, and overall survival of patients with AML. Understanding the pathogenetic role of cytogenetic and molecular changes has led to the development of targeted treatment strategies that require rapid diagnostic assessment of the genetic profile of each patient to select the best treatment available. PMID: 22071913 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=5428233 Fri, 11 Nov 2011 05:00:00 +0100 5428233 http://www.medworm.com/index.php?rid=5428235&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22064918%26dopt%3DAbstract Authors: Kollar K, Seifried E, Henschler R Abstract Mesenchymal stem cells (MSC) represent a stem and progenitor cell population that has been shown to promote tissue recovery in pre-clinical and clinical studies. The study of MSC migration following systemic infusion of exogenous MSC is difficult. The challenges facing these efforts are due to a number of factors, including defining culture conditions for MSC, the phenotype of cultured MSC, the differences observed between cultured MSC and freshly isolated MSC. However, even if, MSC populations consist of a mixture of stem and more committed multipotent progenitors, it remains probable that these cell populations are still useful in the clinic as discussed in this review. PMID: 22064918 [PubMed - in process] (Source: Hamostase... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=5428235 Tue, 01 Nov 2011 04:00:00 +0100 5428235 http://www.medworm.com/index.php?rid=5428234&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22065102%26dopt%3DAbstract Authors: Mayer G, Rohrbach F, Pötzsch B, Müller J Abstract Nucleic acid based aptamers are single-stranded oligonucleotide ligands isolated from random libraries by an in-vitro selection procedure. Through the formation of unique three-dimensional structures, aptamers are able to selectively interact with a variety of target molecules and are therefore also promising candidates for the development of anticoagulant drugs. While thrombin represents the most prominent enzymatic target in this field, also aptamers directed against other coagulation proteins and proteases have been identified with some currently being tested in clinical trials. In this review, we summarize recent developments in the design and evaluation of aptamers for anticoagulant therapy and research. PMID: 22... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=5428234 Tue, 01 Nov 2011 04:00:00 +0100 5428234 http://www.medworm.com/index.php?rid=5332847&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22008738%26dopt%3DAbstract [New anticoagulants : Characteristics, monitoring and management of bleeding.] Med Klin (Munich). 2011 Oct 20; Authors: Heidinger K, Kemkes-Matthes B Abstract Vitamin K antagonists and heparins have been standard anticoagulation drugs over the past decades. They are effective and safe but they have several drawbacks which has led to the development of new oral anticoagulants. Dabigatran etexilate is a specific oral thrombin inhibitor and rivaroxaban and apixaban are oral inhibitors of factor Xa. These agents produce a predictable anticoagulant response after fixed-dose administration so that routine coagulation monitoring is unnecessary. Currently, dabigatran etexilate, rivaroxaban and apixaban are licensed for thromboprophylaxis after elective total hip or knee replacement... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=5332847 Thu, 20 Oct 2011 04:00:00 +0100 5332847 http://www.medworm.com/index.php?rid=5332844&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22009115%26dopt%3DAbstract Authors: Schöchl H, Voelckel W, Maegele M, Solomon C Abstract Trauma-induced coagulopathy (TIC) has been considered for a long time as being due to depletion of coagulation factors secondary to blood loss, dilution and consumption. Dysfunction of the remaining coagulation factors due to hypothermia and acidosis is assumed to additionally contribute to TIC. Recent data suggest that hyperfibrinolysis (HF) represents an additional important confounder to the disturbed coagulation process. Severe shock and major tissue trauma are the main drivers of this HF. The incidence of HF is still speculative. According to visco-elastic testing of trauma patients upon emergency room admission, HF is present in approximately 2.5-7% of all trauma patients. However, visco-elastic tests provide info... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=5332844 Wed, 19 Oct 2011 04:00:00 +0100 5332844 http://www.medworm.com/index.php?rid=5332842&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22009202%26dopt%3DAbstract Authors: Palareti G Abstract Acute venous thromboembolism (VTE) is treated with parenteral administration of heparin or derivatives, in conjunction with oral vitamin K antagonists (VKAs) to reach and maintain INR values between 2.0 and 3.0 for at least 3 months; the duration of a further period of treatment for secondary prevention of recurrences is still matter of debate. If bleeding occurs during treatment the decision will be based on: a) type of bleeding (major or minor), and b) thrombotic risk if anticoagulation is withheld (characteristics of patients and time elapsed from the index VTE). In case of major bleeding anticoagulation should be stopped and reversed. A first but insufficient measure is i.v. vitamin K administration. Fresh frozen plasma is widely used; however, larg... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=5332842 Wed, 19 Oct 2011 04:00:00 +0100 5332842 http://www.medworm.com/index.php?rid=5332846&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22008984%26dopt%3DAbstract Authors: Graf L, Stern M Abstract The transplantation of allogeneic or autologous haematopoietic stem cells is an established treatment for many malignant and non-malignant diseases of the bone marrow. Intensive cytoreductive regimens administered before transplantation induce prolonged and severe cytopenia of all haematopoietic lineages. Thrombocytopenia leads to an increased risk of bleeding, which may be further aggravated by consumption of plasmatic factors as a result of tumour lysis or after antibody administration. At the same time, patients after transplantation are also at increased risk of thrombotic complications. Endothelial damage induced by radio- and chemotherapy, indwelling catheters, prolonged immobilization and a high incidence of systemic infection all contribute... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=5332846 Tue, 18 Oct 2011 04:00:00 +0100 5332846 http://www.medworm.com/index.php?rid=5332845&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22009044%26dopt%3DAbstract Conclusion: It is not justified to withhold any hormonal contraception to thrombophilic women, especially considering the much higher VTE risk in (maybe unintended) pregnancy. Adolescents thrombophilic women should rather be informed about the opportunity to use POC. PMID: 22009044 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=5332845 Tue, 18 Oct 2011 04:00:00 +0100 5332845 http://www.medworm.com/index.php?rid=5332843&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22009166%26dopt%3DAbstract Authors: Emmerechts J, Hoylaerts MF Abstract Ambient environmental air pollutants include gaseous and particulate components. In polluted air, especially particulate matter seems responsible for cardiovascular complications: It consists of a heterogeneous mixture of solid and liquid particles with different diameters ranging from large thoracic to ultrafine particles, with a diameter <100 nm. Ultrafines can penetrate deeply into the lung to deposit in the alveoli. Cardiovascular manifestations result both from short-term and long-term exposure and have been linked to interference with the autonomic nervous system, direct translocation into the systemic circulation, pulmonary inflammation and oxidative stress. Thrombotic complications associated with air pollution comprise arteri... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=5332843 Tue, 18 Oct 2011 04:00:00 +0100 5332843 http://www.medworm.com/index.php?rid=5332848&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21999231%26dopt%3DAbstract Authors: Morfini M, Jiménez-Yuste V, Eichler H, Fischer R, Kirchmaier CM, Scharling B, Bjerre J Abstract Summary.  Recombinant factor VIIa is indicated for treatment of bleeding episodes in patients with haemophilia A or B with inhibitors; in FVII deficiency and in Glanzmann's thrombasthenia. The aim of the study reported here was to compare the pharmacokinetic profiles between two formulations of rFVIIa that are produced in two different cell lines and media: Chinese hamster ovary cells cultured in a serum-free medium (CHO-rFVIIa) and baby hamster kidney cells cultured in a non-human serum-based medium (BHK-rFVIIa). Two clinical trials were performed; one in healthy subjects and the other in patients with congenital haemophilia A or B, with or without inhibitors. Subjects were ... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=5332848 Mon, 17 Oct 2011 04:00:00 +0100 5332848 http://www.medworm.com/index.php?rid=5317310&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21983992%26dopt%3DAbstract Authors: Pabinger I, Alt-Epping B, Demarmels Biasutti F, Langer F, Wörmann B, Riess H Abstract Venous thrombembolism (VTE) is one of the most frequent complication in cancer patients. The current options in prophylaxis and therapy have to be balanced against the risks of major bleeding and the burden for the patients. The Gesellschaft für Thrombose- und Hämostaseforschung, the Deutsche Gesellschaft für Palliativmedizin and the German speaking Societies of Hematology and Oncology have recently published guidelines on VTE in cancer patients. Recommendations include diagnostics, individual prophylaxis and treatment. PMID: 21983992 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=5317310 Mon, 10 Oct 2011 04:00:00 +0100 5317310 http://www.medworm.com/index.php?rid=5302145&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21971578%26dopt%3DAbstract Authors: Falanga A, Russo L Abstract Cancer is associated with a fourfold increased risk of venous thromboembolism (VTE). The risk of VTE varies according to the type of malignancy (i. e. pancreatic cancer, brain cancer, lymphoma) and its disease stage and individual factors (i. e. sex, race, age, previous VTE history, immobilization, obesity). Preventing cancer-associated VTE is important because it represents a significant cause of morbidity and mortality. In order to identify cancer patient at particularly high risk, who need thromboprophylaxis, risk prediction models have become available and are under validation. These models include clinical risk factors, but also begin to incorporate biological markers. The major American and European scientific societies have issued their r... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=5302145 Wed, 05 Oct 2011 04:00:00 +0100 5302145 http://www.medworm.com/index.php?rid=5195601&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21881700%26dopt%3DAbstract Authors: Galli M Abstract The antiphospholipid syndrome (APS) is defined by the association of arterial and/or venous thrombosis and/or pregnancy complications with the presence of at least one among the main antiphospholipid antibodies (aPL) (i. e., Lupus anticoagulants, LA, IgG and/or IgM anticardiolipin antibodies, aCL, IgG and/or IgM antiβ2-glycoprotein I antibodies, aβ2-GPI). Several clinical studies have consistently reported that LA is a stronger risk factor for both arterial and venous thrombosis compared to aCL and aβ2-GPI. In particular, LA activity dependent on the first domain of β2-GPI and triple aPL positivity are associated with the risk of thrombosis and obstetrical complications. Asymptomatic aPL-positive subjects do not require primary thromboprophylaxis. Veno... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=5195601 Wed, 31 Aug 2011 23:00:00 +0100 5195601 http://www.medworm.com/index.php?rid=5142979&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21837355%26dopt%3DAbstract Authors: Prager GW, Poettler M Abstract Etiological concepts on cancer development, malignant growth and tumour propagation have undergone a revolutionary development during recent years: Among other aspects, the discovery of angiogenesis - the growth of new blood vessels from pre-existing vasculature - as a key element in the pathogenesis of malignancy has opened an abundance of biologic insights and subsequent therapeutic options, which have led to improved prognosis in many cancers including those originating from colon, lung, breast and kidney. Thereby, targeting the major pro-angiogenic stimulus vascular endothelial growth factor (VEGF) became the focus for therapeutic interventions. However, the use of VEGF-targeting drugs has been shown to be of limited efficacy, which might... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=5142979 Thu, 11 Aug 2011 23:00:00 +0100 5142979 http://www.medworm.com/index.php?rid=5114368&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21822525%26dopt%3DAbstract Authors: Ay C, Pabinger I Cancer is a major and independent risk factor of venous thromboembolism (VTE). In clinical practice, a high number of VTE events occurs in patients with cancer, and treatment of cancer-associated VTE differs in several aspects from treatment of VTE in the general population. However, treatment in cancer patients remains a major challenge, as the risk of recurrence of VTE as well as the risk of major bleeding during anticoagulation is substantially higher in patients with cancer than in those without cancer. In several clinical trials, different anticoagulants and regimens have been investigated for treatment of acute VTE and secondary prophylaxis in cancer patients to prevent recurrence. Based on the results of these trials, anticoagulant therapy with low-mole... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=5114368 Sun, 07 Aug 2011 23:00:00 +0100 5114368 http://www.medworm.com/index.php?rid=5114367&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21822526%26dopt%3DAbstract Authors: Pabinger I, Ay C Venous thromboembolism (VTE) is a common complication in patients with cancer that causes significant morbidity and mortality. Several patient-, tumour- and treatment-related risk factors for VTE in cancer patients have been identified. An effective and safe thromboprophylaxis in cancer patients at high risk of VTE is desirable. Recently, the identification of potential biomarkers and the development of risk scoring models for prediction of cancer-associated VTE have been published. Whether primary VTE prophylaxis based on risk assessment through these biomarkers and risk prediction models might be useful, is currently not yet known. However, thromboprophylaxis is clearly indicated in high-risk situations. While VTE prophylaxis is recommended in cancer patient... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=5114367 Sun, 07 Aug 2011 23:00:00 +0100 5114367 http://www.medworm.com/index.php?rid=5114366&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21826371%26dopt%3DAbstract Authors: Weiler H The central effector protease of the protein C pathway, activated protein C (APC), interacts with the endothelial cell protein C receptor, with protease activated receptors (PAR), the apolipoprotein E2 receptor, and integrins to exert multiple effects on haemostasis and immune cell function. Such receptor interactions modify the activation of PC and determine the biological response to endogenous and therapeutically administered APC. This review summarizes the current knowledge about interactions of APC with cell surface-associated receptors, novel substrates such as histones and tissue factor pathway inhibitor, and their implications for the biologic function of APC in the control of coagulation and inflammation. PMID: 21826371 [PubMed - in process] (Source: Hamo... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=5114366 Sun, 31 Jul 2011 23:00:00 +0100 5114366 http://www.medworm.com/index.php?rid=5114371&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21792463%26dopt%3DAbstract Authors: Thaler J, Ay C, Pabinger I Cancer patients have a four- to seven-fold increased risk to develop a venous thromboembolic event. Accumulating evidence from experimental and clinical studies indicates that microparticles (MPs), small procoagulant membrane vesicles that are defined by size and a negatively charged phosphatidylserine rich surface, play an important role in the pathogenesis of cancer-related venous thromboembolism (VTE). However, the clinical significance of MPs as a predictive biomarker for VTE in cancer patients has not been fully elucidated yet. This might be due to unresolved methodological problems and a lack of data from large prospective clinical studies that investigate the role of MPs in cancer-related VTE. It is the aim of this review to give an overview o... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=5114371 Tue, 19 Jul 2011 23:00:00 +0100 5114371 http://www.medworm.com/index.php?rid=5114370&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21792464%26dopt%3DAbstract Authors: Schneppenheim R, Budde U Von Willebrand factor (VWF) is an adhesive, multi-functional huge multimerized protein with multiple domains harboring binding sites for collagen, platelet glycoprotein receptors and coagulation factor VIII (FVIII). The functional domains enable VWF to bind to the injured vessel wall, to recruit platelets to the site of injury by adhesion and aggregation and to bind and protect FVIII, an important cofactor of the coagulation cascade. VWF function in primary haemostasis is located in particular in the arterial and micro-circulation. This environment is exposed to high shear forces with hydrodynamic shear rates ranging over several orders of magnitude from 10(-1) to 10(5) s-1 and requires particular mechanisms to enable platelet adhesion and aggregation ... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=5114370 Tue, 19 Jul 2011 23:00:00 +0100 5114370 http://www.medworm.com/index.php?rid=5114369&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21792469%26dopt%3DAbstract Authors: Langer F, Bokemeyer C Cancer is characterized by bidirectional interrelations between tumour progression, coagulation activation, and inflammation. Tissue factor (TF), the principal initiator of the coagulation protease cascade, is centrally positioned in this complex triangular network due to its pleiotropic effects in haemostasis, angiogenesis, and haematogenous metastasis. While formation of macroscopic thrombi is the correlate of cancer-associated venous thromboembolism (VTE), a major healthcare burden in clinical haematology and oncology, microvascular thrombosis appears to be critically important to blood-borne tumour cell dissemination. In this regard, expression of TF in malignant tissues as well as shedding of TF-bearing microparticles into the circulation are thought... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=5114369 Mon, 11 Jul 2011 23:00:00 +0100 5114369 http://www.medworm.com/index.php?rid=5019572&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21713318%26dopt%3DAbstract Authors: Chatrou ML, Reutelingsperger CP, Schurgers LJ Vitamin K was discovered early last century at the same time as the vitamin K-antagonists. For many years the role of vitamin K was solely ascribed to coagulation and coagulation was thought to be involved only at the venous blood side. This view has dramatically changed with the discovery of vitamin K-dependent proteins outside the coagulation cascade and the role of coagulation factors at the arterial side. Vitamin K-dependent proteins are involved in the regulation of vascular smooth muscle cell migration, apoptosis, and calcification. Vascular calcification has become an important independent predictor of cardiovascular disease. Vitamin K-antagonists induce inactivity of inhibitors of vascular calcification, leading to accelera... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=5019572 Tue, 28 Jun 2011 23:00:00 +0100 5019572 http://www.medworm.com/index.php?rid=5019574&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21709931%26dopt%3DAbstract Authors: Clemetson KJ Many more platelets are present in healthy mammals than are necessary for routine haemostasis. Thus, they could have other functions. Platelets have many of the attributes of innate immune function including Toll-like receptors. They also contain a wide range of anti-microbial peptides in storage granules. Platelets play an important role in bacterial infections, both in disease progress and in defence mechanisms depending on circumstances. Similar mechanisms are used in defence against fungi. Platelets are also involved in viral diseases, either in protecting from the immune system or in killing viruses that activate platelets. Finally, platelets have a role in defence against parasitic diseases, in particular malaria, that should not be ignored, and may aggravat... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=5019574 Mon, 27 Jun 2011 23:00:00 +0100 5019574 http://www.medworm.com/index.php?rid=5019573&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21709932%26dopt%3DAbstract Authors: Palareti G Anticoagulation with vitamin K antagonists (VKAs) is effective in the prevention and treatment of thrombotic complications in many clinical conditions, including atrial fibrillation (that represents today the most frequent indication for anticoagulant treatment), venous thromboembolism, acute coronary syndromes and after invasive cardiac procedures. Bleeding is the most important complication of VKAs and a major concern for both physicians and patients, limiting a more widespread prescription of the treatment. As a result, a non negligible proportion of all the subjects who would have a clear clinical indication for anticoagulation do not receive an effective treatment. This review analyses the treatment- and person-associated risk factors for bleeding during VKAs. ... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=5019573 Mon, 27 Jun 2011 23:00:00 +0100 5019573 http://www.medworm.com/index.php?rid=4924230&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21655671%26dopt%3DAbstract Authors: Kanse SM, Etscheid M Factor VII activating protease (FSAP) is a circulating serine protease with high homology to fibrinolytic enzymes. A role in the regulation of coagulation and fibrinolysis is suspected based on in vitro studies demonstrating activation of FVII or pro-urokinase plasminogen activator (uPA). However, considering the paucity of any studies in animal models or any correlative studies in humans the role of FSAP in haemostasis remains unclear. In relation to vascular remodeling processes or inflammation it has been convincingly shown that FSAP interacts with growth factors as well as protease activated receptors (PAR). Against this sparse background there are a plethora of studies which have investigated the linkage of single nucleotide polymorphisms (SNP) in the... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4924230 Tue, 07 Jun 2011 23:00:00 +0100 4924230 http://www.medworm.com/index.php?rid=4924245&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21647535%26dopt%3DAbstract Authors: Rieger M, Endler G, Funk M, Lalouschek W, Lang W, Mannhalter C, Sunder-Plassmann R Overexpression of plasma cell membrane glycoprotein-1 (PC-1) inhibits insulin receptor tyrosine kinase activity and thus favours insulin resistance and atherosclerotic vascular disease. Recent findings indicate that the minor variant K121Q in the PC-1 gene confers an increased risk for early myocardial infarction independent of other established risk factors. We hypothesized that genetic variants in PC-1 may also influence the risk for cerebrovascular disease. Aim: Therefore, we assessed the association of the PC-1 K121Q variant in the coding region and a polymorphism (G2906C) in the 3' untranslated region of the PC-1 gene with the risk of stroke. Patients: We analyzed 1014 patients with a histo... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4924245 Mon, 06 Jun 2011 23:00:00 +0100 4924245 http://www.medworm.com/index.php?rid=4924254&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21629966%26dopt%3DAbstract Authors: Declerck PJ Thrombin activatable fibrinolysis inhibitor (TAFI) was discovered two decades ago as a consequence of the identification of an unstable carboxypeptidase (CPU), which was formed upon thrombin activation of the respective pro-enzyme (proCPU). The antifibrinolytic function of the activated form (TAFIa, CPU) is directly linked to its capacity to remove C-terminal lysines from the surface of the fibrin clot. No endogenous inhibitors have been identified, but TAFIa activity is regulated by its intrinsic temperature-dependent instability with a half-life of 8 to 15 min at 37 °C. A variety of studies have demonstrated a role for TAFI/TAFIa in venous and arterial diseases. In addition, a role in inflammation and cell migration has been shown. Since an elevated level of TAF... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4924254 Tue, 31 May 2011 23:00:00 +0100 4924254 http://www.medworm.com/index.php?rid=4824547&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21457221%26dopt%3DAbstract Conclusions: COX-2 inhibition by rofecoxib attenuates the antithrombotic and antiatherosclerotic effects of ASA during long-term treatment in cholesterol fed rabbits. PMID: 21457221 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4824547 Thu, 31 Mar 2011 23:00:00 +0100 4824547 http://www.medworm.com/index.php?rid=4824546&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21469049%26dopt%3DAbstract Authors: Scharf RE PMID: 21469049 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4824546 Thu, 31 Mar 2011 23:00:00 +0100 4824546 http://www.medworm.com/index.php?rid=4824545&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21528529%26dopt%3DAbstract Authors: Seidel C, Grünwald V mTOR-inhibitors are part of targeted agents and are already in use in the clinic, especially for treatment of metastatic renal cell carcinoma. Distinct from conventional chemotherapeutics, targeted agents imply chronic treatment, which has changed our perspective on the commerce of adverse events (AE). In principle, mTOR-inhibitors are associated with a broad number of AEs. The occurrence of stomatitis, infection, pneumonitis, hyperlipidemia and hyperglycemia are considered major class effects of mTOR-inhibitors. However, severe adverse events remain scarce among mTOR-inhibitors and support chronic use of these agents. Based on their good clinical tolerability mTOR-inhibitors are prone to be developed in combinational therapies. However, the hepatic metab... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4824545 Thu, 31 Mar 2011 23:00:00 +0100 4824545 http://www.medworm.com/index.php?rid=4668701&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21443634%26dopt%3DAbstract In conclusion, N8 is bioequivalent to Advate(®) . Furthermore, N8 is well tolerated in the FHD trial. PMID: 21443634 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4668701 Sun, 27 Mar 2011 23:00:00 +0100 4668701 http://www.medworm.com/index.php?rid=4668702&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21424142%26dopt%3DAbstract Authors: Wolf Z, Mani H, Lindhoff-Last E PMID: 21424142 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4668702 Sun, 06 Mar 2011 00:00:00 +0100 4668702 http://www.medworm.com/index.php?rid=4546061&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21332888%26dopt%3DAbstract Authors: Klamroth R, Pollmann H, Hermans C, Faradji A, Yarlas AS, Epstein JD, Ewenstein BM Summary.  Studies with haemophilia A (HA) patients have shown burden in health-related quality of life (HRQOL) when compared with general population norms. In the current study, HA patients' SF-36v2 health survey scores were compared with general population norms and to patients with other chronic conditions. The impact of target joints (TJs) on HRQOL was also examined. The sample was a subset of HA patients enrolled in the Post-Authorization Safety Surveillance (PASS) programme: a prospective open-label study in which ADVATE [Antihaemophilic Factor (Recombinant), Plasma/Albumin-Free Method] was prescribed. A total of 205 patients who were ≥18 years old and had SF-36v2 baseline scores were ... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4546061 Mon, 21 Feb 2011 00:00:00 +0100 4546061 http://www.medworm.com/index.php?rid=4421031&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21246161%26dopt%3DAbstract Conclusion: The preliminary research assay prototype has the potential for excellent analytical sensitivity, precision, and dynamic range suitable to measure reliably FXIII antigen levels in human plasma. PMID: 21246161 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4421031 Wed, 19 Jan 2011 00:00:00 +0100 4421031 http://www.medworm.com/index.php?rid=4357862&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21219327%26dopt%3DAbstract Authors: Wenzel F, Günther W, Rox JM, Fischer JC, Giers G PMID: 21219327 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4357862 Sat, 01 Jan 2011 00:00:00 +0100 4357862 http://www.medworm.com/index.php?rid=4357863&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21175852%26dopt%3DAbstract Authors: Niederwieser D, Schmitz S The regulation of biosimilars is a process that is still developing. In Europe, guidance regarding the approval and use of biosimilars has evolved with the products under consideration. It is now more than 3 years since the first biosimilar agents in oncology support, erythropoiesis-stimulating agents, were approved in the EU. More recently, biosimilar granulocyte colony-stimulating factors have received marketing approval in Europe. This review considers general issues surrounding the introduction of biosimilars and highlights current specific issues pertinent to their use in clinical practice in oncology. Information on marketing approval, extrapolation, labelling, substitution, immunogenicity and traceability of each biosimilar product is important... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4357863 Wed, 22 Dec 2010 00:00:00 +0100 4357863 http://www.medworm.com/index.php?rid=4357864&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21164077%26dopt%3DAbstract CONCLUSIONS: High glucose enhances SMC responsiveness to thrombin through transcriptional upregulation of PAR-4, mediated via PKC-β, -δ, and NFκB. This may play an important role in the vascular complications of diabetes. PMID: 21164077 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4357864 Thu, 16 Dec 2010 00:00:00 +0100 4357864 http://www.medworm.com/index.php?rid=4259966&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21152674%26dopt%3DAbstract We report a 39-year-old woman who developed spontaneous bleeding five years after surgical creation of an arteriovenous fistula (AVF) for haemodialysis treatment. AVWD type 2A was diagnosed after successful renal transplantation. One year after surgical closure of the AVF, the aVWD could not be verified again. Thus, the aVWD may have developed because of altered blood flow and shear stress inside the arteriovenous fistula. PMID: 21152674 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4259966 Thu, 09 Dec 2010 00:00:00 +0100 4259966 http://www.medworm.com/index.php?rid=4259960&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21152675%26dopt%3DAbstract Authors: Wilkens M An overview is given on the method and the applications of thrombin generation assays. Thrombin generation assays provide a tool which can be used to trace the entire thrombin formation and inactivation of a plasma sample. Therefore they are principally different from traditional global assays like PT and aPTT and promise new opportunities for the assessment of bleeding or thrombotic risks. PMID: 21152675 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4259960 Thu, 09 Dec 2010 00:00:00 +0100 4259960 http://www.medworm.com/index.php?rid=4259947&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21152676%26dopt%3DAbstract Conclusion: The results lead to the assumption that thrombelastometric measurements may not be appropriate for the perioperative monitoring of FXIII concentration. PMID: 21152676 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4259947 Thu, 09 Dec 2010 00:00:00 +0100 4259947 http://www.medworm.com/index.php?rid=4259907&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21152677%26dopt%3DAbstract This article intends to provide an overview of the current platelet function tests such as light transmittance aggregometry, whole blood impedance aggregometry, the PFA-1001 system, the VerifyNow2 system, flow cytometry, as well as other promising technologies like Plateletworks3, IMPACT-R4, PADA, thromboelastography, and the mean platelet component (MPC), briefly addressing strengths, weaknesses and clinical utility of these tests. PMID: 21152677 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4259907 Thu, 09 Dec 2010 00:00:00 +0100 4259907 http://www.medworm.com/index.php?rid=4259888&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21152678%26dopt%3DAbstract Authors: Lipinski S, Bremer L, Lammers T, Thieme F, Schreiber S, Rosenstiel P Overwhelming evidence has linked inflammatory disorders to a hypercoagulable state. In fact, thromboembolic complications are among the leading causes of disability and death in many acute and chronic inflammatory diseases. Despite this clinical knowledge, coagulation and immunity were long regarded as separate entities. Recent studies have unveiled molecular underpinnings of the intimate interconnection between both systems. The studies have clearly shown that distinct pro-inflammatory stimuli also activate the clotting cascade and that coagulation in turn modulates inflammatory signaling pathways. In this review, we use evidence from sepsis and inflammatory bowel diseases as a paradigm for acute and chronic... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4259888 Thu, 09 Dec 2010 00:00:00 +0100 4259888 http://www.medworm.com/index.php?rid=4259865&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21152679%26dopt%3DAbstract Authors: Ivandic B, Frey N Inhibiting platelet function is a key therapeutic principle in cardiology because platelets play a pivotal role in triggering cardiovascular events. In addition to acetylsalicylic acid, a cyclooxygenase inhibitor, ADP-receptor blockers are frequently used for anti-platelet therapy. This therapy does not abolish platelet activation and aggregation. Platelets may still be activated by alternative routes such as the thrombin receptor-mediated pathway. New, more potent inhibitors of platelet function continue to lower the risk of ischaemic events but several trials and clinical registries have also shown that this advantage was frequently offset by an increased risk of bleeding complications. As a consequence, the individual risk of ischaemia and bleeding of a pa... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4259865 Thu, 09 Dec 2010 00:00:00 +0100 4259865 http://www.medworm.com/index.php?rid=4259849&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21152680%26dopt%3DAbstract Authors: Lindhoff-Last E Recurrent venous thromboembolism is associated with increased mortality in 5-9% of the patients. On the other hand prolonged anticoagulation can increase the bleeding risk which can also be responsible for an increased mortality. Therefore, it is necessary to validate the recurrence risk of venous thromboembolism on an individual basis. In this review the most relevant risk factors for recurrent venous thromboembolism are analyzed. Spontaneous thrombosis is associated with significantly increased recurrence rates in comparison to risk associated venous thrombosis. In addition, a positive D-dimer result after stop of anticoagulation, an increased amount of residual thrombus in proximal veins analyzed by compression sonography, a proximal localization of thrombos... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4259849 Thu, 09 Dec 2010 00:00:00 +0100 4259849 http://www.medworm.com/index.php?rid=4229304&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21113252%26dopt%3DAbstract CONCLUSION: Both sample tubes are well qualified for platelet function analysis with the Multiplate system. The new sterile sample tube with dried hirudin may be preferred for better handling. PMID: 21113252 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4229304 Sat, 04 Dec 2010 14:20:03 +0100 4229304 http://www.medworm.com/index.php?rid=4159559&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21057707%26dopt%3DAbstract Authors: Mani H, Wolf Z, Lindhoff-Last E Both for diagnosis of congenital and acquired platelet dysfunction as well as for therapy monitoring after application of platelet function inhibitors various methods have been established for evaluation of platelet function. In contrast to the gold standard of platelet function testing, the light transmission aggregometry in platelet rich plasma the Point-of-care (POC) analyzers allow fast analysis of platelet function without extensive laboratory work up. The conditions of the pre-analytical phase, however, are still of enormous importance in the prevention of medical errors. There is increasing clinical data in monitoring the effect of platelet aggregation inhibitors, showing that quantitative determination of the platelet function degree cor... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4159559 Mon, 08 Nov 2010 00:00:00 +0100 4159559 http://www.medworm.com/index.php?rid=4159558&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21057710%26dopt%3DAbstract Authors: Linsel-Nitschke P, Erdmann J, Schunkert H Myocardial infarction (MI) shows a strong heritability. For a long time the identification of responsible genes has been rather unsuccessful. However, with the advent of genome wide association studies (GWAS) using DNA-array technology a number of significant loci for MI have been identified which were widely replicated. Interestingly, only a small fraction of the hitherto identified genes is also associated with classical risk factors for MI such as hypercholesterolemia or diabetes. Therefore it can be concluded that the MI risk mediated by the newly identified genes involves a number of novel pathophysiological mechanisms. This review summarizes the present state of knowledge in the field and tries to give a perspective on how these ... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4159558 Mon, 08 Nov 2010 00:00:00 +0100 4159558 http://www.medworm.com/index.php?rid=4159557&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21057711%26dopt%3DAbstract [Individualized "minimal invasive" anticoagulation controlled with D-dimer-antigen testing - A concept.] Hamostaseologie. 2010 Nov 8;30(4):190-193 Authors: Müller-Beißenhirtz W, Boschert H, Müller-Beißenhirtz H The aim of the proposed concept is to use anticoagulant therapy in prophylaxis and therapy of thromboembolic events only to an extent that the coagulation activation is just not any longer detectable. It results an individualized anticoagulation tailored to the coagulation activation of the patient (individualized "minimal invasive" anticoagulation). Intensity and control of efficiency are to be monitored by measurement of in vivo coagulation activation, e.g. by D-dimer-antigen measurement. Especially with the use of the new oral anticoagulants such a saver anticoagu... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4159557 Mon, 08 Nov 2010 00:00:00 +0100 4159557 http://www.medworm.com/index.php?rid=4159561&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21046057%26dopt%3DAbstract Authors: König T The Gesundheitsfonds (national health fund) was established in Germany on January 1st, 2009, in combination with the morbidity-based risk structure equalization (RSA) in order to manage the cash flow between the statutory health insurances. The RSA equalizes income differences due to the varying levels of contributory income of the members of a health insurance (basic wage totals) and expenditure differences due to varying distribution of morbidity risks across different health insurances, as well as the varying numbers of non-contributing insured family members. Additionally, insured persons are allocated to morbidity groups according to a classification model based upon diagnoses and prescriptions anticipating medical expenses in the subsequent year. Haemophilia fal... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4159561 Tue, 02 Nov 2010 00:00:00 +0100 4159561 http://www.medworm.com/index.php?rid=4159560&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21046058%26dopt%3DAbstract Conclusion: Both groups showed high test-retest-reliability of Fmaxiso (ICC/SEM: H l = 0.98/7.1 r = 0.99/4.9; K l = 0.69/11.3 r = 0.95/5.8). Starting from the 3rd attempt, reliable measurements of the Fmaxiso in patients suffering from severe haemophilia are feasible. PMID: 21046058 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4159560 Tue, 02 Nov 2010 00:00:00 +0100 4159560 http://www.medworm.com/index.php?rid=4126039&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21042658%26dopt%3DAbstract Authors: Oldenburg J, Kurnik K PMID: 21042658 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4126039 Tue, 02 Nov 2010 00:00:00 +0100 4126039 http://www.medworm.com/index.php?rid=4126036&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21042661%26dopt%3DAbstract Authors: Schramm W, Krebs H Since 1978 an annual multicentric survey regarding the epidemiology of patients suffering of haemophilia is performed with support of hemophilia treating centres of any size. Again the actual compilation is resting upon a broad database returning to over 30 years of inquiry well representing both the actual and retrospective status of mortality. Prompted was exclusively information about patients with haemophilia A, B and von Willebrand disease. In particular anonymous data concerning the last 12 months about number of treated patients, type and severity of illness, HIV-status and detailed information about causes of death was inquired. This data was merged with existing data and analyzed statistically. In the 2008/2009 survey, a total number of 9101 patient... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4126036 Tue, 02 Nov 2010 00:00:00 +0100 4126036 http://www.medworm.com/index.php?rid=4126035&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21042662%26dopt%3DAbstract Conclusion: It is not possible to use the DDAVP test as a diagnostic tool for patients within the diagnostic grey area of VWD. PMID: 21042662 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4126035 Tue, 02 Nov 2010 00:00:00 +0100 4126035 http://www.medworm.com/index.php?rid=4126034&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21042663%26dopt%3DAbstract Authors: Wallny T In particular health economists promise to improve healthcare processes, cost-effectiveness and outcomes by standardised procedures. In the area of EOS indication, operative procedures and postal-surgical pain therapy can partly be standardised. In addition, clinical pathways have impact on the organisation of care if the care process is structured in a standardised way. On these four subjects examples are demonstrated. Elective orthopaedic surgery in haemophilia can be standardised. Nevertheless, it may not be forgotten that these patients can be categorised only restrictedly and the individual, interdisciplinary treatment must be prior to clinical standards. PMID: 21042663 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4126034 Tue, 02 Nov 2010 00:00:00 +0100 4126034 http://www.medworm.com/index.php?rid=4126032&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21042665%26dopt%3DAbstract Conclusion: Additional application of immunoglobulin is beneficial for immune tolerance induction. PMID: 21042665 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4126032 Tue, 02 Nov 2010 00:00:00 +0100 4126032 http://www.medworm.com/index.php?rid=4126031&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21042666%26dopt%3DAbstract Authors: Siegmund B, Richter H, Pollmann H Based on the documentation from patients with severe haemophilia B (FIX:C <1%) in home treatment the positive effect of continuous prophylaxis compared to on demand treatment was investigated over one year in a retrospective study from a single treatment centre (Centre for Haemostaseology Muenster). The advantage of the reduction in the number of bleeding episodes by 90% was opposed by a threefold higher consumption of FIX concentrates and a fourfold higher exposure of the patients to intravenous injections. PMID: 21042666 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4126031 Tue, 02 Nov 2010 00:00:00 +0100 4126031 http://www.medworm.com/index.php?rid=4126030&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21042667%26dopt%3DAbstract Authors: Siegmund B, Richter H, Pollmann H In a retrospective study from a single treatment centre (Centre for Haemostaseology Muenster) the current treatment conditions of patients with severe haemophilia A (FVIII:C <1%) at the age of ≥ 16 years are described. Data were extracted from paper based diaries of patients in home treatment (n = 70). Results: A progressive preference towards prophylactic treatment compared to on demand therapy is observed. On average 2.4 injections per week (mean: 1750 IU FVIII per injection) are used in the prophylactic regimen. The consumption of FVIII concentrates is approximately fivefold increased compared to on demand therapy (average 0.5 injections per week). Meanwhile, recombinant FVIII concentrates have become widely accepted in all age groups,... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4126030 Tue, 02 Nov 2010 00:00:00 +0100 4126030 http://www.medworm.com/index.php?rid=4126029&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21042668%26dopt%3DAbstract Authors: Seuser A, Wallny T, Kurth A, Berdel P Rehabilitation and physical therapy in the sense of functional health is based on the international classification of function. It takes in two considerations: function and structure of the body and their influence on personal and social activity. The integrative concept of joint function translates the basic concept of body function and structure on to the motion of the locomotive system. Stability needs motoric control. Motoric control and the integrated neural components are to be influenced through regulation of muscle tonus (massage, manual therapy, medical training therapy, electrotherapy and thermotherapy). The stability of the joint is controlled by the passive components. Passive structures are optimised through passive therapies ... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4126029 Tue, 02 Nov 2010 00:00:00 +0100 4126029 http://www.medworm.com/index.php?rid=4126027&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21042670%26dopt%3DAbstract Conclusion: Our experiences have shown that self esteem and social integration of haemophilia patients have reached again normality. By our psychosocial counselling we would like to contribute. PMID: 21042670 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4126027 Tue, 02 Nov 2010 00:00:00 +0100 4126027 http://www.medworm.com/index.php?rid=4126024&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21042673%26dopt%3DAbstract Conclusion: According to our results equal safety and efficacy of plasma derived and recombinant FVIII products can be assumed. PMID: 21042673 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4126024 Tue, 02 Nov 2010 00:00:00 +0100 4126024 http://www.medworm.com/index.php?rid=4126023&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21042674%26dopt%3DAbstract Authors: Pollmann H, Siegmund B, Richter H Based on a previous investigation, the aim of this study was to re-evaluate when children with severe haemophilia A (FVIII:C <1%) are diagnosed and when they start to bleed. Data from previously untreated patients (n = 20) were collected. Results: 95% of the patients experienced their first bleeding episode at the age of less than one year. On average, the first non-joint bleed occurred at the age of 0.85 years, whereas the first joint bleed developed approximately a half year later at the age of 1.49 years. Compared to the previous investigation children were diagnosed earlier, i.e. at the age of 3.7 month on average. PMID: 21042674 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4126023 Tue, 02 Nov 2010 00:00:00 +0100 4126023 http://www.medworm.com/index.php?rid=4126022&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21042675%26dopt%3DAbstract Authors: Miesbach W, Krekeler S, Dück O, Llugaliu B, Asmelash G, Schüttrumpf J, Alesci SR, Großmann R The efficacy of DDAVP (1-deamino-8-D-arginine-vasopressin, desmopressin) in mild haemophilia A and von Willebrand disease (VWD) has been established and the use of this well tolerated drug has become clinical routine. In case of increased fluid intake and based on very rarely occurring hyponatraemia, the indication of administration of DDAVP intravenously (i. v.) has to be performed diligently in elderly patients and in children below the age of five years. Aim, patients: Due to clinical practice we were interested in finding prospective parameter potentially correlating with adverse reactions of DDAVP and initiated this study. From 2007 to 2008, we included 49 patients suspicious t... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4126022 Tue, 02 Nov 2010 00:00:00 +0100 4126022 http://www.medworm.com/index.php?rid=4126020&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21042677%26dopt%3DAbstract Conclusion: A clinically relevant influence of valproic acid on haemostasis was found only in few cases. However, before surgical procedures an extended coagulation diagnostics is recommended in patients with valproic acid therapy. PMID: 21042677 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4126020 Tue, 02 Nov 2010 00:00:00 +0100 4126020 http://www.medworm.com/index.php?rid=4126019&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21042678%26dopt%3DAbstract Conclusion: The data suggest a milder bleeding type of patients with severe HB in comparison to patients with severe HA but may be patients with severe HB are at higher risk for intracerebral bleeds. PMID: 21042678 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4126019 Tue, 02 Nov 2010 00:00:00 +0100 4126019 http://www.medworm.com/index.php?rid=4126018&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21042679%26dopt%3DAbstract Authors: Haubold K, Moorthi C, Bade A, Niekrens C, Auerswald G Severe haemophilia A was diagnosed postpartum in a newborn. The mother was known as a conductor (intron 22 inversion) and an uncle had a persistently high titer inhibitor after failed ITI. Due to a cephalhaematoma, a high-dose pdFVIII substitution was given within the first days after birth. At the age of six month a severe cerebral haemorrhage occurred, making a high-dose pdFVIII substitution and neurosurgical intervention necessary. Several days later a porth-a-cath-system was implanted. The development of a high titer inhibitor occured six days later, an ITI was started according to the Bonn Protocol. Initially rFVIIa was given in addition to the pdFVIII substitution. Seven days after the beginning of treatment the inhib... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4126018 Tue, 02 Nov 2010 00:00:00 +0100 4126018 http://www.medworm.com/index.php?rid=4126017&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21042680%26dopt%3DAbstract Authors: Haschberger B, Hesse J, Heiden M, Seitz R, Schramm W The DHR (Deutsches Hämophilieregister, German Haemophilia Register) records patient data on haemophiliaA, haemophiliaB, von Willebrand disease, and other coagulation factor deficiency disorders. The DHR has been online since 2009. The participation in the DHR leads to additional administrative workload for the hospitals and physicians, but provides many advantages as well: A standard of documentation will be developed to give evidence for the hospitals. They may use their own data as well as with new possibilities for data processing at any time. Reports in accordance with Section21 TFG (Transfusionsgesetz, German Transfusion Act) are compiled automatically and transmitted to the Paul-Ehrlich-Institut. The DHR may support t... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4126017 Tue, 02 Nov 2010 00:00:00 +0100 4126017 http://www.medworm.com/index.php?rid=4126016&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21042681%26dopt%3DAbstract Discussion: Total knee replacement in patients with haemophilia improves knee function and quality of life. The results of our study represent results in earlier published studies. Compared to a non-haemophilic normal population the rate of perioperative complications was not increased. PMID: 21042681 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4126016 Tue, 02 Nov 2010 00:00:00 +0100 4126016 http://www.medworm.com/index.php?rid=4126015&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21042682%26dopt%3DAbstract Conclusion: Rituximab appears an effective and well-tolerated treatment for patients with acquired haemophilia. PMID: 21042682 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4126015 Tue, 02 Nov 2010 00:00:00 +0100 4126015 http://www.medworm.com/index.php?rid=4126012&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21042685%26dopt%3DAbstract Authors: Berdel P, Pagenstert G, Randau T, Schott D, Taubner A, Oldenburg J, Seuser A, Wirtz DC, Gravius S The upper ankle joint is one of the target-joints of the haemophilic patient. Therefore, the secondary arthritis of the upper ankle joint is one of the most frequent forms of haemophilic arthropathy. It is a secondary form of arthritis not only because of chronic synovitis and cartilage injury resulting from chronic recurrent intraarticular bleeds, but also due to the misalignment of the joint and abnormal joint stress. The consequences are manifest even in young patients and finally lead to upper ankle joint arthritis. In such clinical situations, the upper ankle joint-arthroplasty is a viable alternative to arthrodesis. After several years of bleeding of the upper ankle joint ma... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4126012 Tue, 02 Nov 2010 00:00:00 +0100 4126012 http://www.medworm.com/index.php?rid=4126011&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21042686%26dopt%3DAbstract Authors: Ballesteros P Haemophilia presents a challenge to every risk adjustment scheme even if it uses diagnostical or pharmaceutical data. The German adjustment scheme developed by the Bundesversicherungsamt realizes fairly cost homogenous groups for many expensive diseases. It does not regard haemophilia. This holds true for the original classification system (grouper) from 2009 and for the improved classification procedure in 2010. The extreme peak costs that can originate from haemophilia cases can present a existential risk for small health plans. The chances to form cost-homogeneous subgroups of the haemophilia disease by more specific coding or other measures seem low because of the small number of cases affected by this disease. The complementary (re-)installation of a expendi... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4126011 Tue, 02 Nov 2010 00:00:00 +0100 4126011 http://www.medworm.com/index.php?rid=4126038&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21042659%26dopt%3DAbstract The objective of the study is to record haemophilia-related arthropathies, which will be defined based on imaging techniques (e. g. MRI, X-ray, ultrasound) and the judgment of the attending physician. In addition, extensive data will be collected on joint replacement surgeries, pseudotumour development, bleeding-related pain, quality of life (age-related questionnaires: Haem-A-QoL, Haemo-QoL, SF10, SF12v2), risk factors (diabetes mellitus, arterial hypertension, nicotine abuse), blood group, gene mutation, physical activity, and on the efficacy and safety of Advate. The patient data will be entered into an electronic CRF system at the centres. Plausibility checks during data entry, regular monitoring visits, and the option of auditing all serve to ensure a high data quality for AHEAD. The ... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4126038 Mon, 01 Nov 2010 00:00:00 +0100 4126038 http://www.medworm.com/index.php?rid=4126037&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21042660%26dopt%3DAbstract Authors: Pavlova A, Delev D, Pahl S, Driesen J, Brondke H, Oldenburg J PMID: 21042660 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4126037 Mon, 01 Nov 2010 00:00:00 +0100 4126037 http://www.medworm.com/index.php?rid=4126033&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21042664%26dopt%3DAbstract Authors: von der Weid N The Swiss Haemophilia Registry of the Medical Committee of the Swiss Haemophilia Society started in 1996 but was set as an internet-based, double password-protected facility in the year 2000. With the inclusion of patients' data from two new centres in 2009, we assume a coverage rate of about 90% of all patients with inherited bleeding disorders in our country. Data concerning the phenotype and genotype of the disorder, its severity, its therapy, the prevalence of inhibitors are readily available to the registered users, allowing quality control of haemophilia therapy at a national level, but also rapid care of the patient visiting the emergency room of another treatment centre. Basing on the available data, about two thirds of the WFH global survey can be answe... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4126033 Mon, 01 Nov 2010 00:00:00 +0100 4126033 http://www.medworm.com/index.php?rid=4126028&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21042669%26dopt%3DAbstract Conclusion: Our results show a higher impact of microparticles on the haemostatic system of newborns than on that of adults. The three methods suggest a somewhat increased microparticle activity in newborn cord plasma, but argue against strong platelet activation during birth. PMID: 21042669 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4126028 Mon, 01 Nov 2010 00:00:00 +0100 4126028 http://www.medworm.com/index.php?rid=4126026&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21042671%26dopt%3DAbstract Conclusion: A lower content of PAR1-receptors explains very well the hyposensitivity of cord platelets to thrombin. Higher levels of CD42b may additionally support the effect of larger more adhesive multimeric vWF in newborn plasma. PMID: 21042671 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4126026 Mon, 01 Nov 2010 00:00:00 +0100 4126026 http://www.medworm.com/index.php?rid=4126025&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21042672%26dopt%3DAbstract This study reports the prevalence and a spatial distribution analysis of both types of the disease in this country. The prevalence of haemophilia in this country is 7 cases per 100000 men, for HA it is 6 cases per 100000 and for HB it is 1 case per 100000 male inhabitants. The prevalence of this disease is low when compared with other populations. This low prevalence could be due to the many patients that have died because of infection with human immunodeficiency virus during the 1980s. The prevalence of haemophilia in Costa Rica is almost one half of that present in developed countries. Nevertheless, the ratio between HA and HB follows world tendency: 5:1. In this study, nationwide geographical distribution maps were drawn in order to visualize the origin of severe cases and how this infl... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4126025 Mon, 01 Nov 2010 00:00:00 +0100 4126025 http://www.medworm.com/index.php?rid=4126021&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21042676%26dopt%3DAbstract Conclusion: Obviously in obese children a hypercoagulable state exists and the slight hyperaggregability observed in whole blood in this cohort might contribute to that. Any effort should be undertaken to avoid obesity in children especially in those countries where the prevalence of obesity in childhood is continuously increasing. PMID: 21042676 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4126021 Mon, 01 Nov 2010 00:00:00 +0100 4126021 http://www.medworm.com/index.php?rid=4126014&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21042683%26dopt%3DAbstract Authors: Bidlingmaier C, Olivieri M, Stelter K, Eberl W, von Kries R, Kurnik K Bleeding after ear-nose-and throat surgery in children is a serious complication. With the help of the German Surveillance Unit for Rare Paediatric Disorders (Erhebungseinheit für seltene pädiatrische Erkrankungen in Deutschland; ESPED) a two year survey was performed to record the incidence, severity, reasons and treatment of haemorrhages. During the study period, 1069 bleeds were reported from 720 paediatric hospitals and departments of otorhinolaryngology after adenoidectomy and tonsillectomy. 713 reports could be analyzed. Two deaths occurred after adenoidectomy. Although laboratory screening was performed in more than 70% of all cases, bleeding complications were neither foreseeable nor preventable. I... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4126014 Mon, 01 Nov 2010 00:00:00 +0100 4126014 http://www.medworm.com/index.php?rid=4126013&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21042684%26dopt%3DAbstract Conclusion: We demonstrated that in adults younger than 45 years without clinically overt atherosclerotic disease ETP was significantly associated with carotid IMT. It is tempting to speculate that ETP may serve as an index for subclinical atherosclerosis in persons below 45 years. PMID: 21042684 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=4126013 Mon, 01 Nov 2010 00:00:00 +0100 4126013 http://www.medworm.com/index.php?rid=3858747&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20700569%26dopt%3DAbstract Authors: Jurk K, Kehrel BE Although their central role is to control bleeding and to induce thrombosis, platelets are important inflammatory and immune cells as well as modulators of angiogenesis. This review focuses on the different roles of platelets in hemostasis, thrombosis, inflammation, arteriosclerosis, angiogenesis, antimicrobial host defense and hematogenous tumor metastasis. Platelets are the central regulators of hemostasis. On their surface the important thrombin burst takes place. Platelets cause atherothrombotic vascular occlusions. However, they are probably involved in early stages of arteriosclerosis, e.g. extravasation of leukocytes at sites of vascular injury, formation of foam cells and proliferation of smooth muscle cells. These processes are triggered by secretion... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=3858747 Wed, 11 Aug 2010 23:00:00 +0100 3858747 http://www.medworm.com/index.php?rid=3858746&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20700570%26dopt%3DAbstract Authors: Wolf Z, Mani H, Lindhoff-Last E Numerous laboratory tests are in use to detect congenital or acquired platelet function disorders. Platelet aggregometry, using ADP, collagen, arachidonic acid or ristocetin as inductor is the standard test system for diagnosis. It is also used to detect platelet non-response to antiplatelet therapy. Studies have demonstrated that laboratory assessment of platelet non response to aspirin or clopidogrel is associated with adverse outcomes, and they indicate the importance of adjusting antiplatelet therapy in patients with a low degree of platelet inhibition. Nevertheless, a standardized method for identifying these patients is still missing. PMID: 20700570 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=3858746 Wed, 11 Aug 2010 23:00:00 +0100 3858746 http://www.medworm.com/index.php?rid=3828263&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20680227%26dopt%3DAbstract Conclusion: In our opinion the light factor XIII deficiency in our patient is coincidental and not the sole cause of bleeding. PMID: 20680227 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=3828263 Sat, 31 Jul 2010 23:00:00 +0100 3828263 http://www.medworm.com/index.php?rid=3828262&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20680228%26dopt%3DAbstract In conclusion, there is compelling evidence that GPIbalpha/VWF interactions and downstream signaling via phospholipase D1 (PLD1) provide new therapeutic targets in ischemic stroke. PMID: 20680228 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=3828262 Sat, 31 Jul 2010 23:00:00 +0100 3828262 http://www.medworm.com/index.php?rid=3828261&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20680229%26dopt%3DAbstract Authors: Wang JW, Eikenboom J Von Willebrand factor (VWF) is a pivotal haemostatic protein mediating platelet adhesion to injured endothelium and carrying coagulation factor VIII (FVIII) in the circulation to protect it from premature clearance. Apart from the roles in haemostasis, VWF drives the formation of the endothelial cell specific Weibel-Palade bodies (WPBs), which serve as a regulated storage of VWF and other thrombotic and inflammatory factors. Defects in VWF could lead to the bleeding disorder von Willebrand disease (VWD). Extensive studies have shown that several mutations identified in VWD patients cause an intracellular retention of VWF. However, the effects of such mutations on the formation and function of its storage organelle are largely unknown. This review gives an ... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=3828261 Sat, 31 Jul 2010 23:00:00 +0100 3828261 http://www.medworm.com/index.php?rid=3828260&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20680230%26dopt%3DAbstract Authors: Hagedorn I, Vögtle T, Nieswandt B Platelet and coagulation factor-dependent thrombus formation is critical to limit posttraumatic blood loss at sites of vascular injury. However, under pathological conditions like rupture of an atherosclerotic plaque, it may also lead to vessel occlusion causing myocardial infarction or stroke. Therefore, antithrombotic treatment is the prime therapeutic option in the prophylaxis and treatment of ischaemic cardio- and cerebrovascular diseases. The use of existing antithrombotic agents is, however, limited by their inherent effect on primary haemostasis. In recent years, major advances have been made in understanding the mechanisms of thrombus formation in haemostasis and thrombosis and some studies raised the interesting possibility that oc... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=3828260 Sat, 31 Jul 2010 23:00:00 +0100 3828260 http://www.medworm.com/index.php?rid=3828259&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20680231%26dopt%3DAbstract In conclusion, unraveling asTF's non-hemostatic properties may generate new insights in the pathophysiology and diagnostics of cancer and cardiovascular disease. PMID: 20680231 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=3828259 Sat, 31 Jul 2010 23:00:00 +0100 3828259 http://www.medworm.com/index.php?rid=3828258&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20680232%26dopt%3DAbstract Conclusion: This monocenter study demonstrates that control of life-threatening bleeding, eradication of the inhibitor, and induction of tolerance to endogenous FVIII have significantly improved the clinical outcome of acquired haemophilia A. Our data also suggest a shift in underlying disorders associated with acquired haemophilia A, whereby, in comparison to published studies, a relative increase in the proportion of patients with respiratory diseases is present. PMID: 20680232 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=3828258 Sat, 31 Jul 2010 23:00:00 +0100 3828258 http://www.medworm.com/index.php?rid=3828257&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20680233%26dopt%3DAbstract Authors: van Os GM, Urbanus RT, Agar C, Meijers JC, de Groot PG The antiphospholipid syndrome (APS) is a non-inflammatory autoimmune disease characterized by the presence of antiphospholipid antibodies (aPL) in the plasma of patients with vascular thrombosis, recurrent complications of pregnancy, or both (1, 2). The presence of aPL in plasma of patients can be detected with either a prolongation of phospholipid dependent coagulation tests (lupus anticoagulant, LAC), or with solid phase immune assays against the protein beta2-glycoprotein I (beta2-GPI) or the phospholipid cardiolipin (anti-beta2-GPI antibody ELISA and anti-cardiolipin antibody ELISA, respectively) (3). For a long time there was a lot of confusion on who had the syndrome and who not. To solve this dispute, an internation... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=3828257 Sat, 31 Jul 2010 23:00:00 +0100 3828257 http://www.medworm.com/index.php?rid=3828256&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20680234%26dopt%3DAbstract Authors: Walter U PMID: 20680234 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=3828256 Sat, 31 Jul 2010 23:00:00 +0100 3828256 http://www.medworm.com/index.php?rid=3737880&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20454750%26dopt%3DAbstract This article specifically addresses laboratories performing molecular genetic tests for diagnosis, prevention and therapy of various diseases. The topics that will be discussed will support these laboratories to achieve and sustain a high quality and avoid mistakes and errors. The article covers important preanalytic, analytic and postanalytic aspects in regard to molecular genetic testing as well as quality management issues. In addition laboratory responsibilities, training of personnel, data protection issues, as well as informed consent aspects will be discussed. Beyond that, some molecular genetic methods will be dealt with in regard to potential quality criteria. PMID: 20454750 [PubMed - indexed for MEDLINE] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=3737880 Fri, 30 Apr 2010 23:00:00 +0100 3737880 http://www.medworm.com/index.php?rid=3737879&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20454751%26dopt%3DAbstract Authors: Endler G, Slavka G, Perkmann T, Haushofer A Due to their complex preanalytics coagulation tests show a higher rate of rejected samples due to insufficient quality and a higher intra- and inter-individual test variability. In the last years several guidelines addressed this issue in an effort to standardize preanalytic procedures. However, in daily laboratory work, these guidelines frequently cannot be fully executed, due to technical limitations or sample transport logistics. In this manuscript several important issues in sample collection, handling and transportation will be discussed. Since the stability and variability of routine coagulation tests such as prothrombin time and partial prothrombin time are significantly influenced by a number of variables such as tube type, m... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=3737879 Fri, 30 Apr 2010 23:00:00 +0100 3737879 http://www.medworm.com/index.php?rid=3737878&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20454752%26dopt%3DAbstract Authors: Spannagl M, Dick A, Junker R In the last years several point of care testing (POCT) systems used for coagulation parameters have been developed and became daily routine. As for other POCT applications (e. g. blood gas analysis) there is a need for user education and continuous improvement of quality assurance. For some POCT coagulation systems a comprehensive quality management has not been established yet. According to the feasibility and availability of control material and system self control each POCT coagulation method described in this article has a varying concept of quality management. Besides a high quality standard in manufacturing systems, devices and reagents the education of the user and the automatic self control of the instrument as well as the application of el... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=3737878 Fri, 30 Apr 2010 23:00:00 +0100 3737878 http://www.medworm.com/index.php?rid=3737877&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20454753%26dopt%3DAbstract Authors: Fritzer-Szekeres M During the 20th century understanding for quality has changed and international and national requirements for quality have been published. Therefore also medical branches started to establish quality management systems. Quality assurance has always been important for medical laboratories. Certification according to the standard ISO 9001 and accreditation according to the standard ISO 17025 have been the proof of fulfilling quality requirements. The relatively new standard ISO 15189 is the first standard for medical laboratories. This standard includes technical and management requirements for the medical laboratory. The main focus is the proof of competence within the personnel. As this standard is accepted throughout the European Union an increase in accred... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=3737877 Fri, 30 Apr 2010 23:00:00 +0100 3737877 http://www.medworm.com/index.php?rid=3737876&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20454754%26dopt%3DAbstract Authors: Dick A, Schwaiger M, Jámbor C Thromboelastography/thromboelastometry (TEG/ROTEM) is widely used in near-patient setting, especially in perioperative and intensive care medicine for the management of acute bleeding. Until now a comprehensive quality management especially an external quality control of TEG/ROTEM results is not established. Here we report about our results of a pilot survey performed in 2008 and 2009 integrated in the External Quality Assessment Schemes (EQAS) performed by INSTAND. According to this first EQAS data ROTEM results can be controlled in external quality schemes using lyophilized plasma samples. The clot firmness (A20) and clot formation kinetics characterized by the alpha-angle showed very good reproducibility both between the participants and bet... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=3737876 Fri, 30 Apr 2010 23:00:00 +0100 3737876 http://www.medworm.com/index.php?rid=3552599&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20454750%26dopt%3DAbstract This article specifically addresses laboratories performing molecular genetic tests for diagnosis, prevention and therapy of various diseases. The topics that will be discussed will support these laboratories to achieve and sustain a high quality and avoid mistakes and errors. The article covers important preanalytic, analytic and postanalytic aspects in regard to molecular genetic testing as well as quality management issues. In addition laboratory responsibilities, training of personnel, data protection issues, as well as informed consent aspects will be discussed. Beyond that, some molecular genetic methods will be dealt with in regard to potential quality criteria. PMID: 20454750 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=3552599 Fri, 30 Apr 2010 23:00:00 +0100 3552599 http://www.medworm.com/index.php?rid=3552598&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20454751%26dopt%3DAbstract Authors: Endler G, Slavka G, Perkmann T, Haushofer A Due to their complex preanalytics coagulation tests show a higher rate of rejected samples due to insufficient quality and a higher intra- and inter-individual test variability. In the last years several guidelines addressed this issue in an effort to standardize preanalytic procedures. However, in daily laboratory work, these guidelines frequently cannot be fully executed, due to technical limitations or sample transport logistics. In this manuscript several important issues in sample collection, handling and transportation will be discussed. Since the stability and variability of routine coagulation tests such as prothrombin time and partial prothrombin time are significantly influenced by a number of variables such as tube type, m... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=3552598 Fri, 30 Apr 2010 23:00:00 +0100 3552598 http://www.medworm.com/index.php?rid=3552597&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20454752%26dopt%3DAbstract Authors: Spannagl M, Dick A, Junker R In the last years several point of care testing (POCT) systems used for coagulation parameters have been developed and became daily routine. As for other POCT applications (e. g. blood gas analysis) there is a need for user education and continous improvement of quality assurance. For some POCT coagulation systems a comprehensive quality management has not been established yet. According to the feasibility and availability of control material and system self control each POCT coagulation method described in this article has a varying concept of quality management. Besides a high quality standard in manufacturing systems, devices and reagents the education of the user and the automatic self control of the instrument as well as the application of ele... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=3552597 Fri, 30 Apr 2010 23:00:00 +0100 3552597 http://www.medworm.com/index.php?rid=3552596&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20454753%26dopt%3DAbstract Authors: Fritzer-Szekeres M During the 20th century understanding for quality has changed and international and national requirements for quality have been published. Therefore also medical branches started to establish quality management systems. Quality assurance has always been important for medical laboratories. Certification according to the standard ISO 9001 and accreditation according to the standard ISO 17025 have been the proof of fulfilling quality requirements. The relatively new standard ISO 15189 is the first standard for medical laboratories. This standard includes technical and management requirements for the medical laboratory. The main focus is the proof of competence within the personnel. As this standard is accepted throughout the European Union an increase in accred... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=3552596 Fri, 30 Apr 2010 23:00:00 +0100 3552596 http://www.medworm.com/index.php?rid=3552595&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20454754%26dopt%3DAbstract Authors: Dick A, Schwaiger M, Jámbor C Thromboelastography/thromboelastometry (TEG(R)/ROTEM(R)) is widely used in near-patient setting, especially in perioperative and intensive care medicine for the management of acute bleeding. Until now a comprehensive quality management especially an external quality control of TEG(R)/ROTEM(R) results is not established. Here we report about our results of a pilot survey performed in 2008 and 2009 integrated in the External Quality Assessment Schemes (EQAS) performed by INSTAND. According to this first EQAS data ROTEM(R) results can be controlled in external quality schemes using lyophilized plasma samples. The clot firmness (A20) and clot formation kinetics characterized by the alpha-angle showed very good reproducibility both between the parti... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=3552595 Fri, 30 Apr 2010 23:00:00 +0100 3552595 http://www.medworm.com/index.php?rid=3288588&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20162247%26dopt%3DAbstract Authors: Levi M Critically ill patients often have systemic activation of both inflammation and coagulation. Increasing evidence points to an extensive cross-talk between these two systems, whereby inflammation not only leads to activation of coagulation, but coagulation also considerably affects inflammatory activity. The intricate relationship between inflammation and coagulation may have major consequences for the pathogenesis of microvascular failure and subsequent multiple organ failure, as a result of severe infection and the associated systemic inflammatory response. Molecular pathways that contribute to inflammation-induced activation of coagulation have been precisely identified. Activation of the coagulation system and ensuing thrombin generation is dependent on an interleuki... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=3288588 Mon, 01 Feb 2010 00:00:00 +0100 3288588 http://www.medworm.com/index.php?rid=3288587&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20162248%26dopt%3DAbstract Authors: Xu J, Lupu F, Esmon CT Inflammation drives arterial, venous and microvascular thrombosis. Chronic inflammation contributes to arterial thrombotic complications, whereas acute inflammation drives venous thrombosis and microvascular thrombosis. Mechanistically, inflammation modulates thrombotic responses by upregulating procoagulants, downregulating anticoagulants and suppressing fibrinolysis. The inflammatory response can also result in cell apoptosis or necrosis. Products released from the dead cells, particularly histones, propagate further inflammation, tissue death and organ failure. Inhibition of histone mediated cytotoxicity appears to be a new mechanism for protecting against this deadly cascade. PMID: 20162248 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=3288587 Mon, 01 Feb 2010 00:00:00 +0100 3288587 http://www.medworm.com/index.php?rid=3288586&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20162249%26dopt%3DAbstract Authors: Greinacher A, Althaus K, Krauel K, Selleng S Heparin-induced thrombocytopenia (HIT), typically occurring in the second week of heparin therapy, is an antibody-mediated adverse drug reaction associated with increased thrombotic risk. The most important antigens are located on platelet factor 4 (PF4)/heparin complexes. HIT is always caused by platelet-activating antibodies, but not all PF4/heparin-reactive antibodies cause HIT. Thus, tests have a high negative, but only a moderate, positive predictive value. Clinical suspicion of HIT requires cessation of heparin and substitution with an alternative anticoagulant. As these drugs have an increased bleeding risk, they should be used in therapeutic doses only if HIT is considered very likely. Avoiding/postponing coumarin is crucial... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=3288586 Mon, 01 Feb 2010 00:00:00 +0100 3288586 http://www.medworm.com/index.php?rid=3288585&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20162250%26dopt%3DAbstract Authors: Watson S, Daly M, Dawood B, Gissen P, Makris M, Mundell S, Wilde J, Mumford A Platelet number or function disorders cause a range of bleeding symptoms from mild to severe. Patients with platelet dysfunction but normal platelet number are the most prevalent and typically have mild bleeding symptoms. The study of this group of patients is particularly difficult because of the lack of a gold-standard test of platelet function and the variable penetrance of the bleeding phenotype among affected individuals. The purpose of this short review is to discuss the way in which this group of patients can be investigated through platelet phenotyping in combination with targeted gene sequencing. This approach has been used recently to identify patients with mutations in key platelet activat... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=3288585 Mon, 01 Feb 2010 00:00:00 +0100 3288585 http://www.medworm.com/index.php?rid=3221486&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20107757%26dopt%3DAbstract Authors: Willeke A, Lindhoff-Last E The main objectives in the treatment of venous thromboembolism are to prevent clot extension and pulmonary embolism, to reduce mortality and to prevent recurrent thromboembolic events as well as postthrombotic disorders. Initial and effective anticoagulation with heparin, preferably with low molecular weight heparin (LMWH), or with fondaparinux is the most important measure. Unfractioned heparin (UFH) is as effective as LMWH, but requires coagulation-monitoring and is associated with a higher risk of heparin-induced thrombocytopenia. In patients with renal insufficiency direct determination of anti-factor Xa activity and dose adjustment is recommended, since drug accumulation can occur over time. In those patients UFH instead of LMWH might be favored... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=3221486 Thu, 28 Jan 2010 00:00:00 +0100 3221486 http://www.medworm.com/index.php?rid=3101428&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19998750%26dopt%3DAbstract Authors: Moser M, Bode C PMID: 19998750 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=3101428 Sun, 01 Nov 2009 00:00:00 +0100 3101428 http://www.medworm.com/index.php?rid=2852250&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19572355%26dopt%3DAbstract Authors: Mani H, Lindhoff-Last E PMID: 19572355 [PubMed - indexed for MEDLINE] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2852250 Thu, 01 Oct 2009 22:52:02 +0100 2852250 http://www.medworm.com/index.php?rid=2769176&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19730811%26dopt%3DAbstract Authors: Schenk JF, Stephan B, Kusma M, Groß J, Eichler H Venous thrombosis and pulmonary embolisms are currently associated with high mortality rates in Europe as well as in the United States (mortality rate >300,000-500,000/year). The highest risk is attributed to orthopedic surgery. Besides the use of antithrombotic agents, surgical and anesthesiological procedures as well as a multitude of trigger mechanisms, many thrombophilic risk conditions have to be considered. The incidence of thrombotic complications could be continuously reduced by the improvement of different antithrombotic strategies and use of drugs. According to national and international guidelines low molecular weight heparins and fondaparinux (besides aPTT adjusted strategies by using unfractionated heparin) ... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2769176 Thu, 03 Sep 2009 23:00:00 +0100 2769176 http://www.medworm.com/index.php?rid=2661279&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19644598%26dopt%3DAbstract Authors: Kössler J, Steigerwald U, Walter U Inhibition of platelet function plays an important role in the treatment and secondary prevention of cardiovascular or cerebrovascular ischemic diseases. Established antiplatelet agents use different pharmacological targets for this role. Acetylic salicylic acid achieves a reduction of thromboxane A2 formation by inhibition of COX-1. Ticlopidin or clopidogrel are ADP-P2Y12 receptor antagonists. Tirofiban, abciximab or eptifibatid are used for the inhibition of the glycoprotein IIb/IIIa receptor which is activated at the surface of platelets preceding the final step of their aggregation. The mechanism of dipyridamole is based on the inhibition of adenosine uptake and of phosphodiesterase-5. Efforts are made to improve antiplatetelet thera... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2661279 Sun, 02 Aug 2009 05:56:02 +0100 2661279 http://www.medworm.com/index.php?rid=2661278&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19644599%26dopt%3DAbstract Authors: Koscielny J, Ziemer S, von Heymann C Oral anticoagulation with a vitamin K-antagonist requires special consideration when surgery or interventional procedures are planned. This is mainly due to the half life of vitamin K-antagonists and to the need for safe and effective anticoagulation prior to and during surgery as well as in the postoperative period. So far, the continuous infusion of unfractionated heparin (UFH) has been the medication of choice to "bridge" patients to surgery. The use of low molecular weight heparins (LMWH) has been prospectively investigated in this setting and represents a safe alternative. The advantages of LMWH are the better dose-response relationship and reduced need for monitoring. This facilitates the bridging procedure to be started out of hospit... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2661278 Sun, 02 Aug 2009 05:56:02 +0100 2661278 http://www.medworm.com/index.php?rid=2661276&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19644601%26dopt%3DAbstract This article provides an overview on current commercially available methods to determine primary haemostasis as a target of drug-mediated anticoagulation. It focuses on whole blood methods only, and references the currently major achievements that have been reported with each method in respect to its clinical use. Advantages and disadvantages of the various methods are presented, based on considerations of platelet physiology, and on feasibility of the procedures. PMID: 19644601 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2661276 Sun, 02 Aug 2009 05:56:02 +0100 2661276 http://www.medworm.com/index.php?rid=2661281&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19644596%26dopt%3DAbstract Authors: Perzborn E Oral factor Xa (FXa) inhibitors are a promising alternative to current anticoagulants. This paper reviews the latest developments of oral direct FXa inhibitors and focuses on those which have been approved for the prevention of venous thromboembolism (VTE) after total hip or knee replacement or are in advanced development and have passed phase II (proof of principle) testing. The most advanced drugs are apixaban, betrixaban, edoxaban, eribaxaban, rivaroxaban, LY517717, TAK-442, and YM150. Rivaroxaban (Xareltoâ) is the first direct FXa inhibitor which has recently been approved for the prevention of VTE in adult patients after elective hip or knee replacement in several countries, including the European Union and Canada. Rivaroxaban has a flat dose-dependent ant... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2661281 Fri, 31 Jul 2009 23:00:00 +0100 2661281 http://www.medworm.com/index.php?rid=2661280&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19644597%26dopt%3DAbstract Authors: Guyer KE Antiplatelet therapy has demonstrated significant clinical benefit in the treatment of acute coronary syndrome. However, as with any treatment strategy it has been unable to prevent all cardiovascular events. This is far from surprising when considering the complexity of arterial thrombosis and more specifically platelet physiology. This lack of treatment success has provoked the introduction of various diagnostic tests and testing platforms with the intent of guiding and optimizing clinical treatment. Such tests have resulted in the generation of clinical data that suggest suboptimal response to antiplatelet agents such as aspirin and clopidogrel. In the case of both aspirin and clopidogrel, this suboptimal response has been termed resistance. Drug resistance would i... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2661280 Fri, 31 Jul 2009 23:00:00 +0100 2661280 http://www.medworm.com/index.php?rid=2661277&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19644600%26dopt%3DAbstract Authors: Schuster B Vitamin K-antagonists and heparin belong to the established indirect acting anticoagulants. For many years these drugs were the only possibility for prophylaxis and treatment of venous and arterial thrombosis. The challenges for the routine laboratory related to the treatment with vitamin K-antagonists and heparin can be regarded as solved. However, in recent years a rapid development of new anticoagulants began. Although they are developed with guidelines for use without monitoring, the control of effective levels may be necessary in selected cases. As a consequence new challenges for the routine laboratory have to be solved. This paper presents an overview concerning monitoring methods. PMID: 19644600 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2661277 Fri, 31 Jul 2009 23:00:00 +0100 2661277 http://www.medworm.com/index.php?rid=2661275&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19644602%26dopt%3DAbstract Authors: Béress L, Bodendiek I, Forssmann WG, Gresch U, Kallsen B, Lammers T, Ständker L, Thieme F, Bruhn HD Comparative investigation concerning gelfiltration as well as haemostaseologic analysis of venoms and venom fractions of some snakes (elapidae and viperidae) have shown that in elapidae an inhibition of coagulation is dominant whilst in viperidae the stimulation of coagulation is of importance. Our investigations produce a basis to select substances for activation of coagulation and substances for inhibition of coagulation. Under pharmacological viewpoints the data may produce information to use snake fractions for anticoagulation or for procoagulant therapy in bleeding tendency. PMID: 19644602 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2661275 Fri, 31 Jul 2009 23:00:00 +0100 2661275 http://www.medworm.com/index.php?rid=2661274&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19644603%26dopt%3DAbstract Authors: Langer E, Ziemer S In respect to the actual discussion of new anticoagulants in secondary haemostasis, we will give a short review on established oral anticoagulation with vitamin K antagonists and parenteral anticoagulation by use of heparin. The different cumarin derivatives phenprocoumon, warfarin, and acenocoumarol are compared concerning to the management and influence of pharmacogenetic and pharmacokinetic factors. Studies to improve the safety of oral anticoagulation by vitamin K supplementation will be briefly discussed. The therapy with heparins include until now some problems of dose-response control. It is necessary to pay attention to contra-indications even for well known anticoagulants. Examples for that will be given. PMID: 19644603 [PubMed - in process] (So... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2661274 Fri, 31 Jul 2009 23:00:00 +0100 2661274 http://www.medworm.com/index.php?rid=2661273&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19644604%26dopt%3DAbstract Authors: Nowak G In contrast to heparins and oral anticoagulants, anti IIa inhibitors (thrombin inhibitors) are able to directly inhibit the protease activity of thrombin and can thereby precisely control the blood coagulation process. Direct thrombin inhibitors are either biosimilars (r-hirudin) or synthetically produced substances (bivalirudin, argatroban, dabigatran). In 1997 r-hirudin was introduced into clinical practice, however due to its narrow therapeutic range and the necessity of drug monitoring it has not gained widespread clinical use by now. Since 2004 and 2005 the synthetic thrombin inhibitors bivalirudin and argatroban, respectively, are available. With dabigatran the first oral synthetic thrombin inhibitor followed in 2008. These four drugs can inhibit even clot bound ... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2661273 Fri, 31 Jul 2009 23:00:00 +0100 2661273 http://www.medworm.com/index.php?rid=2571416&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19572355%26dopt%3DAbstract Resistenz gegenüber ASS und Clopidogrel. Diagnostik, Ursachen, Relevanz eines komplexen Phänomens. Pharm Unserer Zeit. 2009 Jul 1;38(4):342-350 Authors: Mani H, Lindhoff-Last E Die Therapie mit ASS oder Clopidogrel variiert stark. Mit Hilfe verschiedener Thrombozytenfunktionstests konnte gezeigt werden, dass Subgruppen von Patienten unter ASS- und/oder Clopidogrel-Therapie den erwarteten plättchenhemmenden Effekt vermissen lassen. In monozentrischen Studien korrelierte die laborchemische Non-Response mit dem nachfolgenden Auftreten vaskulärer Ereignisse.Der Mechanismus, welcher einer Resistenz zugrunde liegt, konnte bis zum heutigen Zeitpunkt noch nicht erfasst werden und scheint multifaktoriell zu sein. Die Non-Compliance ist möglicherweise der Hauptgr... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2571416 Tue, 30 Jun 2009 23:00:00 +0100 2571416 http://www.medworm.com/index.php?rid=2533752&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19497786%26dopt%3DAbstract Authors: Moog R PMID: 19497786 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2533752 Mon, 01 Jun 2009 23:00:00 +0100 2533752 http://www.medworm.com/index.php?rid=2533770&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19396412%26dopt%3DAbstract Authors: Buchholz S, Ganser A The hematopoietic stem cell transplantation (HSCT) has become a standard therapy for many inherited and acquired disorders of the bone marrow and immune system. Autologous HSCT is mainly done as part of the primary therapy in multiple myeloma and as part of relapse therapy in malignant lymphoma. In contrast, allogeneic HSCT is predominantly performed in patients with acute leukemias. The selection process for allogeneic HSCT takes disease-specific as well as patient-specific factors into account. Risk factors which can predict for poor response to chemotherapy can now be identified in acute myeloid as well as lymphoid leukemia, based on phenotype, cytogenetics, molecular genetics and response to therapy. In these patients allogeneic HSCT can improve overal... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2533770 Thu, 30 Apr 2009 23:00:00 +0100 2533770 http://www.medworm.com/index.php?rid=2533768&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19404511%26dopt%3DAbstract Authors: Auerswald G, Muntean W, Kemkes-Matthes B, Klamroth R, Krause M, Kurnik K, Oldenburg J, Pabinger-Fasching I, Schramm W, Zimmermann R, Zotz RB Recombinant factor VIIa (rFVIIa; NovoSeven) is, besides other indications, authorised for the treatment of bleeding episodes in patients with hereditary haemophilia A or B and inhibitors. Based on the results of three clinical studies, marketing authorisation was granted for the single dose of 270 microg/kg body weight rFVIIa for the treatment of mild to moderate bleeding episodes in patients with haemophilia A or B with inhibitors in March 2007. Thereupon, an expert group analysed the relevance of this additional treatment option for clinical routine. Compared with the repeated application of 90 microg/kg body weight rFVIIa, quality of l... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2533768 Thu, 30 Apr 2009 23:00:00 +0100 2533768 http://www.medworm.com/index.php?rid=2533767&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19404512%26dopt%3DAbstract We report on a patient with a high titre FVIII inhibitor that persisted after ITI but spontaneously disappeared 15 years later. PMID: 19404512 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2533767 Thu, 30 Apr 2009 23:00:00 +0100 2533767 http://www.medworm.com/index.php?rid=2533766&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19404513%26dopt%3DAbstract CONCLUSION: In children with progressive thrombocytopenia in the setting of heparin exposure and signs of major or micro thrombosis HIT II must be ruled out. Even if a first early test turns out negative repeated testing should be performed. Lepirudin anticoagulation is effective and should be monitored correctly. Platelet transfusion should be avoided in HITII. PMID: 19404513 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2533766 Thu, 30 Apr 2009 23:00:00 +0100 2533766 http://www.medworm.com/index.php?rid=2533765&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19404514%26dopt%3DAbstract CONCLUSION: In case of a bleeding tendency diagnostic procedures should rule out primary haemostatic defects. Hereditary platelet function defects including ALD are an important differential diagnosis. Family studies are reasonable. PMID: 19404514 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2533765 Thu, 30 Apr 2009 23:00:00 +0100 2533765 http://www.medworm.com/index.php?rid=2533764&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19404515%26dopt%3DAbstract Authors: Olivieri M, Kurnik K, Bidlingmaier C Every year in Germany nearly 3000 cases of child abuse were reported. When children are presented at emergency units with suspicious injuries and bruises a detailed documentation an evaluation is necessary after emergency treatment. As differential diagnosis inherited or acquired bleeding disorders should be excluded. In addition to a detailed evaluation of personal and family history and a physical evaluation different coagulation test to exclude defects of primary and secondary hemostasis should be performed. Clinician must know the limitations of these tests and keep in mind that an abnormal coagulation test does not exclude child abuse. Coagulation defects may be the consequence of child abuse and neglect or the two conditions may coexi... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2533764 Thu, 30 Apr 2009 23:00:00 +0100 2533764 http://www.medworm.com/index.php?rid=2533763&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19404516%26dopt%3DAbstract Authors: Hainmann I, Oldenburg J, Pavlova A, Superti-Furga A, Zieger B The genotype-phenotype relationship of compound heterozygous factor X deficiency in a young girl with severe factor X deficiency and bleeding symptoms is characterized. We identified a novel deletion of exon 6 and a missense mutation (c.856G>A, Val286Met) in exon 7 of the F10 gene leading to a compound heterozygous state and causing severe factor X deficiency. Therapeutic options for patients with symptomatic factor X deficiency are demonstrated. PMID: 19404516 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2533763 Thu, 30 Apr 2009 23:00:00 +0100 2533763 http://www.medworm.com/index.php?rid=2533762&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19404517%26dopt%3DAbstract We report on a large Swiss family of whom four family members suffer from BSS. Here, a homozygous missense mutation in position 1829 (A(R)G) of the GPIX gene constituting a N45S substitution is the cause for the bleeding symptoms. A total of 38 family members within two generations were analyzed regarding the N45S mutation by DNA sequencing and restriction fragment length polymorphism. The laboratory parameters which are characteristically for BSS such as platelet count, platelet volume and the expression of CD42a (GPIX), CD42b (GPIbalpha) and CD41 (GPIIb) were measured for all 38 individuals. The four homozygous patients showed bleeding symptoms, thrombocytopenia and giant platelets. In these patients, the expression of CD42a (GPIX), CD42b (GPIbalpha) was diminished. Interestingly, the in... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2533762 Thu, 30 Apr 2009 23:00:00 +0100 2533762 http://www.medworm.com/index.php?rid=2533761&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19404518%26dopt%3DAbstract Authors: Eberl W, Budde U, Bentele K, Christen HJ, Knapp R, Mey A, Schneppenheim R To determine the frequency and clinical relevance of acquired von Willebrand syndrome (aVWS) due to antiepileptic therapy by valproic acid, we investigated 50 consecutive children in three neuropediatric institutions. Coagulation factors were determined in local laboratories before and three times after starting therapy with valproic acid. Parameters of von Willebrand factor (VWF) were additionally investigated in a reference laboratory including multimeric analysis. Significant changes in the coagulation system were found concerning fibrinogen (decreased from 287 +/- 70 mg/dl to 222 +/- 67 mg/dl; p < 0.001) and platelet count. Changes of VWF parameters were also found but no patient developed laborat... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2533761 Thu, 30 Apr 2009 23:00:00 +0100 2533761 http://www.medworm.com/index.php?rid=2533760&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19404519%26dopt%3DAbstract We present a case of successful inhibitor elimination with a combined immune-modulating therapy and high-dose factor IX (FIX). This boy had developed a FIX inhibitor at the age of 5 years and had a history of allergic reactions to FIX and to FEIBAO. Under on-demand treatment with recombinant activated FVII the inhibitor became undetectable but the boy suffered from multiple joint and muscle bleeds. At the age of 11.5 years ITI was attempted with a combination of rituximab, MMF, dexamethasone, intravenous immunoglobulins and high-dose FIX. The inhibitor did not reappear and FIX half-life normalized. No allergic reaction, no signs of nephrotic syndrome and no serious infections were observed. PMID: 19404519 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2533760 Thu, 30 Apr 2009 23:00:00 +0100 2533760 http://www.medworm.com/index.php?rid=2533759&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19404520%26dopt%3DAbstract CONCLUSION: This case emphasizes the necessity to establish the molecular diagnosis in the family's index case and to perform expression studies of novel mutations to prove their causative nature. PMID: 19404520 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2533759 Thu, 30 Apr 2009 23:00:00 +0100 2533759 http://www.medworm.com/index.php?rid=2533758&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19404521%26dopt%3DAbstract Authors: Laws HJ, Janssen G, Borkhardt A Approximately 70% of children have the acute form of immune thrombocytopenia (ITP), which is defined by recovery within six months of presentation with or without treatment. Chronic ITP is to be reserved for patients with platelets < 100000/microl for more than twelve months and exclusion of other diagnosis like systemic lupus erythematosus or bone marrow failures. In children, the chance of spontaneous recovery is 52% after diagnosis of chronic ITP. The Intercontinental Childhood ITP Study group recommends that children without bleeding may not require therapy regardless of their platelet count. Whereas in patients with bleeding symptoms first line therapy is defined and includes steroids or immunoglobuline, second line therapy in refractory... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2533758 Thu, 30 Apr 2009 23:00:00 +0100 2533758 http://www.medworm.com/index.php?rid=2533757&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19404522%26dopt%3DAbstract CONCLUSION: Rituximab may be favourable for patients with congenital haemophilia, high-titre inhibitors and a severe clinical course in whom standard ITI has failed. Prospective studies are required to determine safety, efficacy and predictors of success. PMID: 19404522 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2533757 Thu, 30 Apr 2009 23:00:00 +0100 2533757 http://www.medworm.com/index.php?rid=2533756&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19404523%26dopt%3DAbstract CONCLUSION: Thrombophilic women are good candidates for progestin-only contraceptive methods. PMID: 19404523 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2533756 Thu, 30 Apr 2009 23:00:00 +0100 2533756 http://www.medworm.com/index.php?rid=2533755&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19404524%26dopt%3DAbstract CONCLUSION: Children with VWD type 2 show a variable response to desmopressin depending on the mutation that correlates with the functional defect and the presence or absence as well as the half-life of large VWF multimers. Our data emphasize the usefulness of DDAVP testing even in patients with VWD type 2, possibly with the exception of VWD type 2B. PMID: 19404524 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2533755 Thu, 30 Apr 2009 23:00:00 +0100 2533755 http://www.medworm.com/index.php?rid=2533754&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19404525%26dopt%3DAbstract Authors: Maak B, Kochhan L, Heuchel P, Jenderny J A 14 year old boy was referred to us for a detailed coagulation study because a previously performed aPTT has been found prolonged. The boy had no history of bleeding symptoms and also the family history was negative for bleeding or thrombotic events. The aPTT in the patient was 96 s (reference range: 24-36 s), prothrombin time and thrombin time were both normal. As the cause for the prolonged aPTT we identified a severe prekallikrein deficiency (prekallikrein activity < 1%). The prekallikrein deficiency results from two mutations in the KLKB 1-gene: first, an insertion of 1 bp in codon 149 in exon 5 and, second, a base exchange Cys 548 (TGC) > Tyr (TAC) in exon 14. The boy inherited the first mutation from his father and the seco... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2533754 Thu, 30 Apr 2009 23:00:00 +0100 2533754 http://www.medworm.com/index.php?rid=2533753&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19492466%26dopt%3DAbstract Authors: Schneppenheim R PMID: 19492466 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2533753 Thu, 30 Apr 2009 23:00:00 +0100 2533753 http://www.medworm.com/index.php?rid=2277624&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19295254%26dopt%3DAbstract Authors: Grünwald V, Soltau J, Ivanyi P, Rentschler J, Reuter C, Drevs J This review will provide physicians and oncologists with an overview of side effects related to targeted agents that inhibit vascular endothelial growth factor (VEGF), epidermal growth factor (EGF) and mammalian target of rapamycin (mTOR) signaling in the treatment of solid tumors. Such targeted agents can be divided into monoclonal antibodies, tyrosine kinase inhibitors, multitargeted tyrosine kinase inhibitors and serine/threonine kinase inhibitors. Molecular targeted therapies are generally well tolerated, but inhibitory effects on the biological function of the targets in healthy tissue can result in specific treatment-related side effects, particularly with multitargeted agents. We offer some guidance on... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2277624 Sun, 01 Mar 2009 05:00:00 +0100 2277624 http://www.medworm.com/index.php?rid=2120696&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19151839%26dopt%3DAbstract Authors: Mann KG, Orfeo T, Butenas S, Undas A, Brummel-Ziedins K Our studies involve computational simulations, a reconstructed plasma/platelet proteome, whole blood in vitro and blood exuding from microvascular wounds. All studies indicate that in normal haemostasis, the binding of tissue factor (TF) with plasma factor (F) VIIa (extrinsic FXase complex) results in the initiation phase of the procoagulant response. This phase is negatively regulated by tissue factor pathway inhibitor (TFPI) in combination with antithrombin (AT) and the protein C (PC) pathway. The synergy between these inhibitors provides a threshold-limited reaction in which a stimulus of sufficient magnitude must be provided for continuation of the reaction. With sufficient stimulus, the FXa produced activates some pr... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2120696 Thu, 22 Jan 2009 06:54:03 +0100 2120696 http://www.medworm.com/index.php?rid=2120695&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19151840%26dopt%3DAbstract Authors: Denis CV, Marx I, Badirou I, Pendu R, Christophe O Von Willebrand factor (VWF) structure-function relationship has been studied only through in vitro approaches. The VWF-deficient mouse model has been extremely useful to examine the in vivo function of VWF but does not allow a more subtle analysis of the relative importance of its different domains. However, considering the large size of VWF and its capacity to interact with various ligands in order to support platelet adhesion and aggregation, the necessity to evaluate independently these interactions appeared increasingly crucial. A recently developed technique, known as hydrodynamic injection, which allows transient expression of a transgene by mouse hepatocytes, proved very useful in this regard. Indeed, transient expressi... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2120695 Thu, 22 Jan 2009 06:53:54 +0100 2120695 http://www.medworm.com/index.php?rid=2120694&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19151841%26dopt%3DAbstract Authors: Reininger AJ Blood platelets are the first line of defense against bleeding and as such involved in the haemostatic repair of damaged vasculature. Their true prowess seems to be displayed under high shear conditions where platelets interact with a variety of plasma proteins, all of which are tightly regulated to close the leak but at the same time prevent lumen occlusion and thromboembolism. The first task is to arrest fast flowing platelets on exposed collagen of the damaged subendothelial surface. Although platelets are endowed with several collagen receptors, most notably integrin alpha2bbeta1 and the immunoglobulin superfamily member GPVI, they can not arrest platelets at high shear rates. The latter requires binding of the platelet receptor GPIbalpha to the A1-binding dom... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2120694 Thu, 22 Jan 2009 06:53:49 +0100 2120694 http://www.medworm.com/index.php?rid=2120693&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19151842%26dopt%3DAbstract Authors: Harrison P Platelet function testing is essential for the diagnosis of congenital/acquired bleeding disorders and may be useful for the prediction of surgical bleeding. Nowadays there is also much interest in monitoring the efficacy of anti-platelet therapy and measuring platelet hyper-function. However, this often presents clinical laboratories with significant challenges as platelet function tests are complex, poorly standardized, time consuming and quality assurance is not straightforward. There are also few comprehensive modern guidelines available and many recent published surveys have revealed poor standardization between laboratories. Up until the late 1980's the traditional clinical platelet function tests that were available were the bleeding time (BT), light transmis... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2120693 Thu, 22 Jan 2009 06:53:46 +0100 2120693 http://www.medworm.com/index.php?rid=2120692&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19151843%26dopt%3DAbstract Authors: Paulinska P, Spiel A, Jilma B Plasma levels of von Willebrand factor (VWF) are increased in patients with cardiovascular risk factors. Various studies aimed to elucidate the relation of VWF with thromboembolic cardiovascular events, ischaemic stroke as well as with peripheral arterial occlusive disease. In the general population, there is only a weak association between VWF levels and future cardiovascular events or stroke. In contrast, VWF levels are predictive in patients with documented vascular disease. Those patients with increased VWF suffer a higher incidence of major adverse cardiac events including death. The extent of the VWF release and its levels independently predict clinical outcome in patients with acute coronary syndromes. Elevated VWF levels have also been obs... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2120692 Thu, 22 Jan 2009 06:53:42 +0100 2120692 http://www.medworm.com/index.php?rid=2120691&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19151844%26dopt%3DAbstract Authors: Boon RA, Horrevoets AJ Atherosclerotic plaque rupture and subsequent thrombosis is the main cause of sudden coronary death. Remarkably, atherosclerosis only develops in certain predisposed areas of the vasculature. Endothelial cells in these predisposed areas experience low or oscillatory shear stress, which activates the proinflammatory and procoagulant transcription factors activator protein 1 (AP-1) and nuclear factor kappaB (NFkappaB), thus inducing a proinflammatory, procoagulant surface. In contrast, healthy endothelial cells that are exposed to prolonged high laminar shear stress, express anti-inflammatory and anticoagulant genes. The key shear stress-induced transcription factors that govern the expression of these genes are Krüppel-like factor 2 (KLF2) and nuclea... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2120691 Thu, 22 Jan 2009 06:53:36 +0100 2120691 http://www.medworm.com/index.php?rid=2120690&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19151845%26dopt%3DAbstract Authors: Lijnen HR Obesity is a common disorder and a known risk factor for vascular thrombotic complications. Development of obesity is associated with extensive modifications in adipose tissue involving adipogenesis, angiogenesis and extracellular matrix proteolysis. Studies using a nutritionally induced obesity model in transgenic mice support a role of the fibrinolytic (plasminogen/plasmin) and matrix metalloproteinase (MMP) systems in these processes. Venous or arterial thrombosis models in obese mice confirm a prothrombotic risk associated with obesity. PMID: 19151845 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2120690 Thu, 22 Jan 2009 06:53:33 +0100 2120690 http://www.medworm.com/index.php?rid=2120688&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19151847%26dopt%3DAbstract Authors: Castellana D, Kunzelmann C, Freyssinet JM Microvesicles (MV) are submicrometric membrane fragments (0.1 to 1 mum), released from the plasma membrane of activated or apoptotic cells. They are characterized by most of the antigenic profile of the cells they originate from, and by the presence of procoagulant phospholipids at their surface. MV are detectable in the peripheral blood of mammals and considered as efficient effectors in the haemostatic or thrombotic responses, able to remotely initiate or amplify beneficial or deleterious processes, depending on the circumstances. Variations in their level and phenotype make them relevant pathogenic markers of thrombotic disorders and vascular damage. To date, MV are recognized as mediators of communication allowing cells to influenc... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2120688 Thu, 22 Jan 2009 06:53:26 +0100 2120688