MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Hamostaseologie' source. Sun, 21 Mar 2010 15:13:08 +0100 http://www.medworm.com/index.php?rid=3288588&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20162247%26dopt%3DAbstract Authors: Levi M Critically ill patients often have systemic activation of both inflammation and coagulation. Increasing evidence points to an extensive cross-talk between these two systems, whereby inflammation not only leads to activation of coagulation, but coagulation also considerably affects inflammatory activity. The intricate relationship between inflammation and coagulation may have major consequences for the pathogenesis of microvascular failure and subsequent multiple organ failure, as a result of severe infection and the associated systemic inflammatory response. Molecular pathways that contribute to inflammation-induced activation of coagulation have been precisely identified. Activation of the coagulation system and ensuing thrombin generation is dependent on an interleuki... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=3288588 Mon, 01 Feb 2010 00:00:00 +0100 3288588 http://www.medworm.com/index.php?rid=3288587&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20162248%26dopt%3DAbstract Authors: Xu J, Lupu F, Esmon CT Inflammation drives arterial, venous and microvascular thrombosis. Chronic inflammation contributes to arterial thrombotic complications, whereas acute inflammation drives venous thrombosis and microvascular thrombosis. Mechanistically, inflammation modulates thrombotic responses by upregulating procoagulants, downregulating anticoagulants and suppressing fibrinolysis. The inflammatory response can also result in cell apoptosis or necrosis. Products released from the dead cells, particularly histones, propagate further inflammation, tissue death and organ failure. Inhibition of histone mediated cytotoxicity appears to be a new mechanism for protecting against this deadly cascade. PMID: 20162248 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=3288587 Mon, 01 Feb 2010 00:00:00 +0100 3288587 http://www.medworm.com/index.php?rid=3288586&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20162249%26dopt%3DAbstract Authors: Greinacher A, Althaus K, Krauel K, Selleng S Heparin-induced thrombocytopenia (HIT), typically occurring in the second week of heparin therapy, is an antibody-mediated adverse drug reaction associated with increased thrombotic risk. The most important antigens are located on platelet factor 4 (PF4)/heparin complexes. HIT is always caused by platelet-activating antibodies, but not all PF4/heparin-reactive antibodies cause HIT. Thus, tests have a high negative, but only a moderate, positive predictive value. Clinical suspicion of HIT requires cessation of heparin and substitution with an alternative anticoagulant. As these drugs have an increased bleeding risk, they should be used in therapeutic doses only if HIT is considered very likely. Avoiding/postponing coumarin is crucial... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=3288586 Mon, 01 Feb 2010 00:00:00 +0100 3288586 http://www.medworm.com/index.php?rid=3288585&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20162250%26dopt%3DAbstract Authors: Watson S, Daly M, Dawood B, Gissen P, Makris M, Mundell S, Wilde J, Mumford A Platelet number or function disorders cause a range of bleeding symptoms from mild to severe. Patients with platelet dysfunction but normal platelet number are the most prevalent and typically have mild bleeding symptoms. The study of this group of patients is particularly difficult because of the lack of a gold-standard test of platelet function and the variable penetrance of the bleeding phenotype among affected individuals. The purpose of this short review is to discuss the way in which this group of patients can be investigated through platelet phenotyping in combination with targeted gene sequencing. This approach has been used recently to identify patients with mutations in key platelet activat... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=3288585 Mon, 01 Feb 2010 00:00:00 +0100 3288585 http://www.medworm.com/index.php?rid=3221486&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20107757%26dopt%3DAbstract Authors: Willeke A, Lindhoff-Last E The main objectives in the treatment of venous thromboembolism are to prevent clot extension and pulmonary embolism, to reduce mortality and to prevent recurrent thromboembolic events as well as postthrombotic disorders. Initial and effective anticoagulation with heparin, preferably with low molecular weight heparin (LMWH), or with fondaparinux is the most important measure. Unfractioned heparin (UFH) is as effective as LMWH, but requires coagulation-monitoring and is associated with a higher risk of heparin-induced thrombocytopenia. In patients with renal insufficiency direct determination of anti-factor Xa activity and dose adjustment is recommended, since drug accumulation can occur over time. In those patients UFH instead of LMWH might be favored... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=3221486 Thu, 28 Jan 2010 00:00:00 +0100 3221486 http://www.medworm.com/index.php?rid=3101428&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19998750%26dopt%3DAbstract Authors: Moser M, Bode C PMID: 19998750 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=3101428 Sun, 01 Nov 2009 00:00:00 +0100 3101428 http://www.medworm.com/index.php?rid=2852250&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19572355%26dopt%3DAbstract Authors: Mani H, Lindhoff-Last E PMID: 19572355 [PubMed - indexed for MEDLINE] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2852250 Thu, 01 Oct 2009 22:52:02 +0100 2852250 http://www.medworm.com/index.php?rid=2769176&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19730811%26dopt%3DAbstract Authors: Schenk JF, Stephan B, Kusma M, Groß J, Eichler H Venous thrombosis and pulmonary embolisms are currently associated with high mortality rates in Europe as well as in the United States (mortality rate >300,000-500,000/year). The highest risk is attributed to orthopedic surgery. Besides the use of antithrombotic agents, surgical and anesthesiological procedures as well as a multitude of trigger mechanisms, many thrombophilic risk conditions have to be considered. The incidence of thrombotic complications could be continuously reduced by the improvement of different antithrombotic strategies and use of drugs. According to national and international guidelines low molecular weight heparins and fondaparinux (besides aPTT adjusted strategies by using unfractionated heparin) ... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2769176 Thu, 03 Sep 2009 23:00:00 +0100 2769176 http://www.medworm.com/index.php?rid=2661279&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19644598%26dopt%3DAbstract Authors: Kössler J, Steigerwald U, Walter U Inhibition of platelet function plays an important role in the treatment and secondary prevention of cardiovascular or cerebrovascular ischemic diseases. Established antiplatelet agents use different pharmacological targets for this role. Acetylic salicylic acid achieves a reduction of thromboxane A2 formation by inhibition of COX-1. Ticlopidin or clopidogrel are ADP-P2Y12 receptor antagonists. Tirofiban, abciximab or eptifibatid are used for the inhibition of the glycoprotein IIb/IIIa receptor which is activated at the surface of platelets preceding the final step of their aggregation. The mechanism of dipyridamole is based on the inhibition of adenosine uptake and of phosphodiesterase-5. Efforts are made to improve antiplatetelet thera... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2661279 Sun, 02 Aug 2009 05:56:02 +0100 2661279 http://www.medworm.com/index.php?rid=2661278&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19644599%26dopt%3DAbstract Authors: Koscielny J, Ziemer S, von Heymann C Oral anticoagulation with a vitamin K-antagonist requires special consideration when surgery or interventional procedures are planned. This is mainly due to the half life of vitamin K-antagonists and to the need for safe and effective anticoagulation prior to and during surgery as well as in the postoperative period. So far, the continuous infusion of unfractionated heparin (UFH) has been the medication of choice to "bridge" patients to surgery. The use of low molecular weight heparins (LMWH) has been prospectively investigated in this setting and represents a safe alternative. The advantages of LMWH are the better dose-response relationship and reduced need for monitoring. This facilitates the bridging procedure to be started out of hospit... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2661278 Sun, 02 Aug 2009 05:56:02 +0100 2661278 http://www.medworm.com/index.php?rid=2661276&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19644601%26dopt%3DAbstract This article provides an overview on current commercially available methods to determine primary haemostasis as a target of drug-mediated anticoagulation. It focuses on whole blood methods only, and references the currently major achievements that have been reported with each method in respect to its clinical use. Advantages and disadvantages of the various methods are presented, based on considerations of platelet physiology, and on feasibility of the procedures. PMID: 19644601 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2661276 Sun, 02 Aug 2009 05:56:02 +0100 2661276 http://www.medworm.com/index.php?rid=2661281&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19644596%26dopt%3DAbstract Authors: Perzborn E Oral factor Xa (FXa) inhibitors are a promising alternative to current anticoagulants. This paper reviews the latest developments of oral direct FXa inhibitors and focuses on those which have been approved for the prevention of venous thromboembolism (VTE) after total hip or knee replacement or are in advanced development and have passed phase II (proof of principle) testing. The most advanced drugs are apixaban, betrixaban, edoxaban, eribaxaban, rivaroxaban, LY517717, TAK-442, and YM150. Rivaroxaban (Xareltoâ) is the first direct FXa inhibitor which has recently been approved for the prevention of VTE in adult patients after elective hip or knee replacement in several countries, including the European Union and Canada. Rivaroxaban has a flat dose-dependent ant... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2661281 Fri, 31 Jul 2009 23:00:00 +0100 2661281 http://www.medworm.com/index.php?rid=2661280&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19644597%26dopt%3DAbstract Authors: Guyer KE Antiplatelet therapy has demonstrated significant clinical benefit in the treatment of acute coronary syndrome. However, as with any treatment strategy it has been unable to prevent all cardiovascular events. This is far from surprising when considering the complexity of arterial thrombosis and more specifically platelet physiology. This lack of treatment success has provoked the introduction of various diagnostic tests and testing platforms with the intent of guiding and optimizing clinical treatment. Such tests have resulted in the generation of clinical data that suggest suboptimal response to antiplatelet agents such as aspirin and clopidogrel. In the case of both aspirin and clopidogrel, this suboptimal response has been termed resistance. Drug resistance would i... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2661280 Fri, 31 Jul 2009 23:00:00 +0100 2661280 http://www.medworm.com/index.php?rid=2661277&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19644600%26dopt%3DAbstract Authors: Schuster B Vitamin K-antagonists and heparin belong to the established indirect acting anticoagulants. For many years these drugs were the only possibility for prophylaxis and treatment of venous and arterial thrombosis. The challenges for the routine laboratory related to the treatment with vitamin K-antagonists and heparin can be regarded as solved. However, in recent years a rapid development of new anticoagulants began. Although they are developed with guidelines for use without monitoring, the control of effective levels may be necessary in selected cases. As a consequence new challenges for the routine laboratory have to be solved. This paper presents an overview concerning monitoring methods. PMID: 19644600 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2661277 Fri, 31 Jul 2009 23:00:00 +0100 2661277 http://www.medworm.com/index.php?rid=2661275&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19644602%26dopt%3DAbstract Authors: Béress L, Bodendiek I, Forssmann WG, Gresch U, Kallsen B, Lammers T, Ständker L, Thieme F, Bruhn HD Comparative investigation concerning gelfiltration as well as haemostaseologic analysis of venoms and venom fractions of some snakes (elapidae and viperidae) have shown that in elapidae an inhibition of coagulation is dominant whilst in viperidae the stimulation of coagulation is of importance. Our investigations produce a basis to select substances for activation of coagulation and substances for inhibition of coagulation. Under pharmacological viewpoints the data may produce information to use snake fractions for anticoagulation or for procoagulant therapy in bleeding tendency. PMID: 19644602 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2661275 Fri, 31 Jul 2009 23:00:00 +0100 2661275 http://www.medworm.com/index.php?rid=2661274&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19644603%26dopt%3DAbstract Authors: Langer E, Ziemer S In respect to the actual discussion of new anticoagulants in secondary haemostasis, we will give a short review on established oral anticoagulation with vitamin K antagonists and parenteral anticoagulation by use of heparin. The different cumarin derivatives phenprocoumon, warfarin, and acenocoumarol are compared concerning to the management and influence of pharmacogenetic and pharmacokinetic factors. Studies to improve the safety of oral anticoagulation by vitamin K supplementation will be briefly discussed. The therapy with heparins include until now some problems of dose-response control. It is necessary to pay attention to contra-indications even for well known anticoagulants. Examples for that will be given. PMID: 19644603 [PubMed - in process] (So... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2661274 Fri, 31 Jul 2009 23:00:00 +0100 2661274 http://www.medworm.com/index.php?rid=2661273&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19644604%26dopt%3DAbstract Authors: Nowak G In contrast to heparins and oral anticoagulants, anti IIa inhibitors (thrombin inhibitors) are able to directly inhibit the protease activity of thrombin and can thereby precisely control the blood coagulation process. Direct thrombin inhibitors are either biosimilars (r-hirudin) or synthetically produced substances (bivalirudin, argatroban, dabigatran). In 1997 r-hirudin was introduced into clinical practice, however due to its narrow therapeutic range and the necessity of drug monitoring it has not gained widespread clinical use by now. Since 2004 and 2005 the synthetic thrombin inhibitors bivalirudin and argatroban, respectively, are available. With dabigatran the first oral synthetic thrombin inhibitor followed in 2008. These four drugs can inhibit even clot bound ... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2661273 Fri, 31 Jul 2009 23:00:00 +0100 2661273 http://www.medworm.com/index.php?rid=2571416&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19572355%26dopt%3DAbstract Resistenz gegenüber ASS und Clopidogrel. Diagnostik, Ursachen, Relevanz eines komplexen Phänomens. Pharm Unserer Zeit. 2009 Jul 1;38(4):342-350 Authors: Mani H, Lindhoff-Last E Die Therapie mit ASS oder Clopidogrel variiert stark. Mit Hilfe verschiedener Thrombozytenfunktionstests konnte gezeigt werden, dass Subgruppen von Patienten unter ASS- und/oder Clopidogrel-Therapie den erwarteten plättchenhemmenden Effekt vermissen lassen. In monozentrischen Studien korrelierte die laborchemische Non-Response mit dem nachfolgenden Auftreten vaskulärer Ereignisse.Der Mechanismus, welcher einer Resistenz zugrunde liegt, konnte bis zum heutigen Zeitpunkt noch nicht erfasst werden und scheint multifaktoriell zu sein. Die Non-Compliance ist möglicherweise der Hauptgr... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2571416 Tue, 30 Jun 2009 23:00:00 +0100 2571416 http://www.medworm.com/index.php?rid=2533752&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19497786%26dopt%3DAbstract Authors: Moog R PMID: 19497786 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2533752 Mon, 01 Jun 2009 23:00:00 +0100 2533752 http://www.medworm.com/index.php?rid=2533770&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19396412%26dopt%3DAbstract Authors: Buchholz S, Ganser A The hematopoietic stem cell transplantation (HSCT) has become a standard therapy for many inherited and acquired disorders of the bone marrow and immune system. Autologous HSCT is mainly done as part of the primary therapy in multiple myeloma and as part of relapse therapy in malignant lymphoma. In contrast, allogeneic HSCT is predominantly performed in patients with acute leukemias. The selection process for allogeneic HSCT takes disease-specific as well as patient-specific factors into account. Risk factors which can predict for poor response to chemotherapy can now be identified in acute myeloid as well as lymphoid leukemia, based on phenotype, cytogenetics, molecular genetics and response to therapy. In these patients allogeneic HSCT can improve overal... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2533770 Thu, 30 Apr 2009 23:00:00 +0100 2533770 http://www.medworm.com/index.php?rid=2533768&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19404511%26dopt%3DAbstract Authors: Auerswald G, Muntean W, Kemkes-Matthes B, Klamroth R, Krause M, Kurnik K, Oldenburg J, Pabinger-Fasching I, Schramm W, Zimmermann R, Zotz RB Recombinant factor VIIa (rFVIIa; NovoSeven) is, besides other indications, authorised for the treatment of bleeding episodes in patients with hereditary haemophilia A or B and inhibitors. Based on the results of three clinical studies, marketing authorisation was granted for the single dose of 270 microg/kg body weight rFVIIa for the treatment of mild to moderate bleeding episodes in patients with haemophilia A or B with inhibitors in March 2007. Thereupon, an expert group analysed the relevance of this additional treatment option for clinical routine. Compared with the repeated application of 90 microg/kg body weight rFVIIa, quality of l... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2533768 Thu, 30 Apr 2009 23:00:00 +0100 2533768 http://www.medworm.com/index.php?rid=2533767&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19404512%26dopt%3DAbstract We report on a patient with a high titre FVIII inhibitor that persisted after ITI but spontaneously disappeared 15 years later. PMID: 19404512 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2533767 Thu, 30 Apr 2009 23:00:00 +0100 2533767 http://www.medworm.com/index.php?rid=2533766&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19404513%26dopt%3DAbstract CONCLUSION: In children with progressive thrombocytopenia in the setting of heparin exposure and signs of major or micro thrombosis HIT II must be ruled out. Even if a first early test turns out negative repeated testing should be performed. Lepirudin anticoagulation is effective and should be monitored correctly. Platelet transfusion should be avoided in HITII. PMID: 19404513 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2533766 Thu, 30 Apr 2009 23:00:00 +0100 2533766 http://www.medworm.com/index.php?rid=2533765&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19404514%26dopt%3DAbstract CONCLUSION: In case of a bleeding tendency diagnostic procedures should rule out primary haemostatic defects. Hereditary platelet function defects including ALD are an important differential diagnosis. Family studies are reasonable. PMID: 19404514 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2533765 Thu, 30 Apr 2009 23:00:00 +0100 2533765 http://www.medworm.com/index.php?rid=2533764&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19404515%26dopt%3DAbstract Authors: Olivieri M, Kurnik K, Bidlingmaier C Every year in Germany nearly 3000 cases of child abuse were reported. When children are presented at emergency units with suspicious injuries and bruises a detailed documentation an evaluation is necessary after emergency treatment. As differential diagnosis inherited or acquired bleeding disorders should be excluded. In addition to a detailed evaluation of personal and family history and a physical evaluation different coagulation test to exclude defects of primary and secondary hemostasis should be performed. Clinician must know the limitations of these tests and keep in mind that an abnormal coagulation test does not exclude child abuse. Coagulation defects may be the consequence of child abuse and neglect or the two conditions may coexi... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2533764 Thu, 30 Apr 2009 23:00:00 +0100 2533764 http://www.medworm.com/index.php?rid=2533763&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19404516%26dopt%3DAbstract Authors: Hainmann I, Oldenburg J, Pavlova A, Superti-Furga A, Zieger B The genotype-phenotype relationship of compound heterozygous factor X deficiency in a young girl with severe factor X deficiency and bleeding symptoms is characterized. We identified a novel deletion of exon 6 and a missense mutation (c.856G>A, Val286Met) in exon 7 of the F10 gene leading to a compound heterozygous state and causing severe factor X deficiency. Therapeutic options for patients with symptomatic factor X deficiency are demonstrated. PMID: 19404516 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2533763 Thu, 30 Apr 2009 23:00:00 +0100 2533763 http://www.medworm.com/index.php?rid=2533762&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19404517%26dopt%3DAbstract We report on a large Swiss family of whom four family members suffer from BSS. Here, a homozygous missense mutation in position 1829 (A(R)G) of the GPIX gene constituting a N45S substitution is the cause for the bleeding symptoms. A total of 38 family members within two generations were analyzed regarding the N45S mutation by DNA sequencing and restriction fragment length polymorphism. The laboratory parameters which are characteristically for BSS such as platelet count, platelet volume and the expression of CD42a (GPIX), CD42b (GPIbalpha) and CD41 (GPIIb) were measured for all 38 individuals. The four homozygous patients showed bleeding symptoms, thrombocytopenia and giant platelets. In these patients, the expression of CD42a (GPIX), CD42b (GPIbalpha) was diminished. Interestingly, the in... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2533762 Thu, 30 Apr 2009 23:00:00 +0100 2533762 http://www.medworm.com/index.php?rid=2533761&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19404518%26dopt%3DAbstract Authors: Eberl W, Budde U, Bentele K, Christen HJ, Knapp R, Mey A, Schneppenheim R To determine the frequency and clinical relevance of acquired von Willebrand syndrome (aVWS) due to antiepileptic therapy by valproic acid, we investigated 50 consecutive children in three neuropediatric institutions. Coagulation factors were determined in local laboratories before and three times after starting therapy with valproic acid. Parameters of von Willebrand factor (VWF) were additionally investigated in a reference laboratory including multimeric analysis. Significant changes in the coagulation system were found concerning fibrinogen (decreased from 287 +/- 70 mg/dl to 222 +/- 67 mg/dl; p < 0.001) and platelet count. Changes of VWF parameters were also found but no patient developed laborat... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2533761 Thu, 30 Apr 2009 23:00:00 +0100 2533761 http://www.medworm.com/index.php?rid=2533760&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19404519%26dopt%3DAbstract We present a case of successful inhibitor elimination with a combined immune-modulating therapy and high-dose factor IX (FIX). This boy had developed a FIX inhibitor at the age of 5 years and had a history of allergic reactions to FIX and to FEIBAO. Under on-demand treatment with recombinant activated FVII the inhibitor became undetectable but the boy suffered from multiple joint and muscle bleeds. At the age of 11.5 years ITI was attempted with a combination of rituximab, MMF, dexamethasone, intravenous immunoglobulins and high-dose FIX. The inhibitor did not reappear and FIX half-life normalized. No allergic reaction, no signs of nephrotic syndrome and no serious infections were observed. PMID: 19404519 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2533760 Thu, 30 Apr 2009 23:00:00 +0100 2533760 http://www.medworm.com/index.php?rid=2533759&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19404520%26dopt%3DAbstract CONCLUSION: This case emphasizes the necessity to establish the molecular diagnosis in the family's index case and to perform expression studies of novel mutations to prove their causative nature. PMID: 19404520 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2533759 Thu, 30 Apr 2009 23:00:00 +0100 2533759 http://www.medworm.com/index.php?rid=2533758&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19404521%26dopt%3DAbstract Authors: Laws HJ, Janssen G, Borkhardt A Approximately 70% of children have the acute form of immune thrombocytopenia (ITP), which is defined by recovery within six months of presentation with or without treatment. Chronic ITP is to be reserved for patients with platelets < 100000/microl for more than twelve months and exclusion of other diagnosis like systemic lupus erythematosus or bone marrow failures. In children, the chance of spontaneous recovery is 52% after diagnosis of chronic ITP. The Intercontinental Childhood ITP Study group recommends that children without bleeding may not require therapy regardless of their platelet count. Whereas in patients with bleeding symptoms first line therapy is defined and includes steroids or immunoglobuline, second line therapy in refractory... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2533758 Thu, 30 Apr 2009 23:00:00 +0100 2533758 http://www.medworm.com/index.php?rid=2533757&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19404522%26dopt%3DAbstract CONCLUSION: Rituximab may be favourable for patients with congenital haemophilia, high-titre inhibitors and a severe clinical course in whom standard ITI has failed. Prospective studies are required to determine safety, efficacy and predictors of success. PMID: 19404522 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2533757 Thu, 30 Apr 2009 23:00:00 +0100 2533757 http://www.medworm.com/index.php?rid=2533756&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19404523%26dopt%3DAbstract CONCLUSION: Thrombophilic women are good candidates for progestin-only contraceptive methods. PMID: 19404523 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2533756 Thu, 30 Apr 2009 23:00:00 +0100 2533756 http://www.medworm.com/index.php?rid=2533755&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19404524%26dopt%3DAbstract CONCLUSION: Children with VWD type 2 show a variable response to desmopressin depending on the mutation that correlates with the functional defect and the presence or absence as well as the half-life of large VWF multimers. Our data emphasize the usefulness of DDAVP testing even in patients with VWD type 2, possibly with the exception of VWD type 2B. PMID: 19404524 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2533755 Thu, 30 Apr 2009 23:00:00 +0100 2533755 http://www.medworm.com/index.php?rid=2533754&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19404525%26dopt%3DAbstract Authors: Maak B, Kochhan L, Heuchel P, Jenderny J A 14 year old boy was referred to us for a detailed coagulation study because a previously performed aPTT has been found prolonged. The boy had no history of bleeding symptoms and also the family history was negative for bleeding or thrombotic events. The aPTT in the patient was 96 s (reference range: 24-36 s), prothrombin time and thrombin time were both normal. As the cause for the prolonged aPTT we identified a severe prekallikrein deficiency (prekallikrein activity < 1%). The prekallikrein deficiency results from two mutations in the KLKB 1-gene: first, an insertion of 1 bp in codon 149 in exon 5 and, second, a base exchange Cys 548 (TGC) > Tyr (TAC) in exon 14. The boy inherited the first mutation from his father and the seco... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2533754 Thu, 30 Apr 2009 23:00:00 +0100 2533754 http://www.medworm.com/index.php?rid=2533753&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19492466%26dopt%3DAbstract Authors: Schneppenheim R PMID: 19492466 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2533753 Thu, 30 Apr 2009 23:00:00 +0100 2533753 http://www.medworm.com/index.php?rid=2277624&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19295254%26dopt%3DAbstract Authors: Grünwald V, Soltau J, Ivanyi P, Rentschler J, Reuter C, Drevs J This review will provide physicians and oncologists with an overview of side effects related to targeted agents that inhibit vascular endothelial growth factor (VEGF), epidermal growth factor (EGF) and mammalian target of rapamycin (mTOR) signaling in the treatment of solid tumors. Such targeted agents can be divided into monoclonal antibodies, tyrosine kinase inhibitors, multitargeted tyrosine kinase inhibitors and serine/threonine kinase inhibitors. Molecular targeted therapies are generally well tolerated, but inhibitory effects on the biological function of the targets in healthy tissue can result in specific treatment-related side effects, particularly with multitargeted agents. We offer some guidance on... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2277624 Sun, 01 Mar 2009 05:00:00 +0100 2277624 http://www.medworm.com/index.php?rid=2120696&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19151839%26dopt%3DAbstract Authors: Mann KG, Orfeo T, Butenas S, Undas A, Brummel-Ziedins K Our studies involve computational simulations, a reconstructed plasma/platelet proteome, whole blood in vitro and blood exuding from microvascular wounds. All studies indicate that in normal haemostasis, the binding of tissue factor (TF) with plasma factor (F) VIIa (extrinsic FXase complex) results in the initiation phase of the procoagulant response. This phase is negatively regulated by tissue factor pathway inhibitor (TFPI) in combination with antithrombin (AT) and the protein C (PC) pathway. The synergy between these inhibitors provides a threshold-limited reaction in which a stimulus of sufficient magnitude must be provided for continuation of the reaction. With sufficient stimulus, the FXa produced activates some pr... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2120696 Thu, 22 Jan 2009 06:54:03 +0100 2120696 http://www.medworm.com/index.php?rid=2120695&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19151840%26dopt%3DAbstract Authors: Denis CV, Marx I, Badirou I, Pendu R, Christophe O Von Willebrand factor (VWF) structure-function relationship has been studied only through in vitro approaches. The VWF-deficient mouse model has been extremely useful to examine the in vivo function of VWF but does not allow a more subtle analysis of the relative importance of its different domains. However, considering the large size of VWF and its capacity to interact with various ligands in order to support platelet adhesion and aggregation, the necessity to evaluate independently these interactions appeared increasingly crucial. A recently developed technique, known as hydrodynamic injection, which allows transient expression of a transgene by mouse hepatocytes, proved very useful in this regard. Indeed, transient expressi... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2120695 Thu, 22 Jan 2009 06:53:54 +0100 2120695 http://www.medworm.com/index.php?rid=2120694&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19151841%26dopt%3DAbstract Authors: Reininger AJ Blood platelets are the first line of defense against bleeding and as such involved in the haemostatic repair of damaged vasculature. Their true prowess seems to be displayed under high shear conditions where platelets interact with a variety of plasma proteins, all of which are tightly regulated to close the leak but at the same time prevent lumen occlusion and thromboembolism. The first task is to arrest fast flowing platelets on exposed collagen of the damaged subendothelial surface. Although platelets are endowed with several collagen receptors, most notably integrin alpha2bbeta1 and the immunoglobulin superfamily member GPVI, they can not arrest platelets at high shear rates. The latter requires binding of the platelet receptor GPIbalpha to the A1-binding dom... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2120694 Thu, 22 Jan 2009 06:53:49 +0100 2120694 http://www.medworm.com/index.php?rid=2120693&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19151842%26dopt%3DAbstract Authors: Harrison P Platelet function testing is essential for the diagnosis of congenital/acquired bleeding disorders and may be useful for the prediction of surgical bleeding. Nowadays there is also much interest in monitoring the efficacy of anti-platelet therapy and measuring platelet hyper-function. However, this often presents clinical laboratories with significant challenges as platelet function tests are complex, poorly standardized, time consuming and quality assurance is not straightforward. There are also few comprehensive modern guidelines available and many recent published surveys have revealed poor standardization between laboratories. Up until the late 1980's the traditional clinical platelet function tests that were available were the bleeding time (BT), light transmis... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2120693 Thu, 22 Jan 2009 06:53:46 +0100 2120693 http://www.medworm.com/index.php?rid=2120692&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19151843%26dopt%3DAbstract Authors: Paulinska P, Spiel A, Jilma B Plasma levels of von Willebrand factor (VWF) are increased in patients with cardiovascular risk factors. Various studies aimed to elucidate the relation of VWF with thromboembolic cardiovascular events, ischaemic stroke as well as with peripheral arterial occlusive disease. In the general population, there is only a weak association between VWF levels and future cardiovascular events or stroke. In contrast, VWF levels are predictive in patients with documented vascular disease. Those patients with increased VWF suffer a higher incidence of major adverse cardiac events including death. The extent of the VWF release and its levels independently predict clinical outcome in patients with acute coronary syndromes. Elevated VWF levels have also been obs... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2120692 Thu, 22 Jan 2009 06:53:42 +0100 2120692 http://www.medworm.com/index.php?rid=2120691&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19151844%26dopt%3DAbstract Authors: Boon RA, Horrevoets AJ Atherosclerotic plaque rupture and subsequent thrombosis is the main cause of sudden coronary death. Remarkably, atherosclerosis only develops in certain predisposed areas of the vasculature. Endothelial cells in these predisposed areas experience low or oscillatory shear stress, which activates the proinflammatory and procoagulant transcription factors activator protein 1 (AP-1) and nuclear factor kappaB (NFkappaB), thus inducing a proinflammatory, procoagulant surface. In contrast, healthy endothelial cells that are exposed to prolonged high laminar shear stress, express anti-inflammatory and anticoagulant genes. The key shear stress-induced transcription factors that govern the expression of these genes are Krüppel-like factor 2 (KLF2) and nuclea... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2120691 Thu, 22 Jan 2009 06:53:36 +0100 2120691 http://www.medworm.com/index.php?rid=2120690&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19151845%26dopt%3DAbstract Authors: Lijnen HR Obesity is a common disorder and a known risk factor for vascular thrombotic complications. Development of obesity is associated with extensive modifications in adipose tissue involving adipogenesis, angiogenesis and extracellular matrix proteolysis. Studies using a nutritionally induced obesity model in transgenic mice support a role of the fibrinolytic (plasminogen/plasmin) and matrix metalloproteinase (MMP) systems in these processes. Venous or arterial thrombosis models in obese mice confirm a prothrombotic risk associated with obesity. PMID: 19151845 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2120690 Thu, 22 Jan 2009 06:53:33 +0100 2120690 http://www.medworm.com/index.php?rid=2120688&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19151847%26dopt%3DAbstract Authors: Castellana D, Kunzelmann C, Freyssinet JM Microvesicles (MV) are submicrometric membrane fragments (0.1 to 1 mum), released from the plasma membrane of activated or apoptotic cells. They are characterized by most of the antigenic profile of the cells they originate from, and by the presence of procoagulant phospholipids at their surface. MV are detectable in the peripheral blood of mammals and considered as efficient effectors in the haemostatic or thrombotic responses, able to remotely initiate or amplify beneficial or deleterious processes, depending on the circumstances. Variations in their level and phenotype make them relevant pathogenic markers of thrombotic disorders and vascular damage. To date, MV are recognized as mediators of communication allowing cells to influenc... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2120688 Thu, 22 Jan 2009 06:53:26 +0100 2120688 http://www.medworm.com/index.php?rid=2120686&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19151849%26dopt%3DAbstract Authors: Bidlingmaier C, Eberl W, Knöfler R, Olivieri M, Kurnik K In Germany, preoperative coagulation tests are commonly used, based on the belief that these tests should identify patients with an increased bleeding risk. However, published evidence does not longer support this approach for both traditional screening tests and novel techniques of global assessment of haemostasis. Unselected screening yields many false positive results and detects irrelevant disorders. It leads to postponement of surgery, anxiety in parents and patients, and is not cost effective. Even worse, it does not reliably detect relevant bleeding disorders such as the most common coagulopathy, von Willebrand disease. The bleeding history of patients and their relatives is a more effective tool to detect pa... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2120686 Thu, 22 Jan 2009 06:53:18 +0100 2120686 http://www.medworm.com/index.php?rid=2120685&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19151850%26dopt%3DAbstract Authors: Levi M Recombinant activated factor VII (rFVIIa) is a pro-haemostatic agent that can be used for patients with haemophilia and inhibiting antibodies towards a coagulation factor. Recombinant factor VIIa is, however, increasingly used for several other indications, including patients who experience serious and life-threatening bleeding. In addition, rFVIIa has been evaluated for the prevention of major blood loss in patients undergoing surgical procedures that are known to be associated with major blood loss. In this manuscript we review the data on efficacy and safety of rFVIIa in the prevention of excessive blood loss and transfusion requirements in the perioperative period. We conclude that recombinant factor VIIa is a promising agent for perioperative prevention of major bl... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2120685 Thu, 22 Jan 2009 06:53:13 +0100 2120685 http://www.medworm.com/index.php?rid=2120684&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19151851%26dopt%3DAbstract Authors: Lillicrap D The current treatment of haemophilia with coagulation protein replacement therapy is both effective and safe. Nevertheless, this therapy requires frequent, repeated intravenous infusions and approximately 25% of treated haemophilia A patients develop antibodies to the replacement protein. Furthermore, the cost and limited availability of current concentrates has restricted access to therapy to less than 30% of the global haemophilia population. With this background, efforts are now underway to develop coagulation concentrates with enhanced biological properties that further improve the quality of care for haemophiliacs. The specific areas of enhancement that are being explored include improved biosynthetic processes, prolonging the circulating half-life and reducin... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2120684 Thu, 22 Jan 2009 06:53:07 +0100 2120684 http://www.medworm.com/index.php?rid=2120683&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19151852%26dopt%3DAbstract Authors: Bolton-Maggs P Immune thrombocytopenia in children is usually a self-limiting illness, but in adults the disease is likely to be chronic, and may be associated with other pathology which predisposes to bleeding. Despite very low platelet counts serious bleeding is rare in both adults and children. More than 80% of children have mild clinical manifestations. Intracranial haemorrhage is rare at all ages, is unpredictable and can occur at any time when the count is very low. Currently recommended therapies for both adults and children are associated with significant side effects and occasional deaths. Treatment may interfere with quality of life more than the illness itself. Drugs can be withheld in the majority of children with appropriate advice to child and family. Treatment c... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2120683 Thu, 22 Jan 2009 06:53:04 +0100 2120683 http://www.medworm.com/index.php?rid=2120682&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19151853%26dopt%3DAbstract Authors: Rodeghiero F, Ruggeri M First generation thrombopoietic growth factors (rhTPO and PEG-rHuMGDF), investigated in the early 2000s, proved effective in increasing platelet count in normal volunteers, in thrombocytopenia due to chemotherapy and also in a few cases of immune thrombocytopenic purpura (ITP). These agents did not complete their clinical development since one of them induced antibodies in the recipients that cross reacted with endogenous thrombopoietin (TPO), thus causing thrombocytopenia. This promoted the ingenious design of a new generation of thrombopoietic growth factors having no sequence homology with natural TPO. The two main agents are romiplostim, a peptibody already approved for clinical use in USA and eltrombopag, a non-peptide, orally active small molecule... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2120682 Thu, 22 Jan 2009 06:53:00 +0100 2120682 http://www.medworm.com/index.php?rid=2120681&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19151854%26dopt%3DAbstract Authors: Yang J, Paredes N, Chan AK Antithrombotic therapy has recently become more frequent for the treatment of venous thromboembolism (VTE) in the paediatric population. This can be explained by the increased awareness of morbidities and mortalities of VTE in children, as well as the improved survival rate of children with various kinds of serious illnesses. Considering the large number of years a child is expected to survive, associated morbidities such as postthrombotic syndrome and risk of recurrence can significantly impact on the quality of life in children. Therefore, timely diagnosis, evidence-based treatment and prophylaxis strategies are critical to avoid such complications. This review summarizes the current literature about the antithrombotic treatment for VTE in infants ... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2120681 Thu, 22 Jan 2009 06:52:57 +0100 2120681 http://www.medworm.com/index.php?rid=2120678&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19151857%26dopt%3DAbstract Authors: Lip GY, Krishnamoorthy S Cardioembolism accounts for approximately 20% of ischaemic strokes, and is associated with high mortality and propensity to recurrences. Approximately, 30% of ischaemic strokes remain cryptogenic despite improved imaging modalities and technological improvements to identify their cause. Of the long list of various cardiac conditions associated with an increased risk of cardioembolic strokes, non-valvular atrial fibrillation is the most common cause. Unsurprisingly, the stroke risk associated with these conditions is highly variable and non-homogenous, with many risk factors additive to the overall risk profile. Treatment with vitamin K-antagonists substantially reduces the long-term complications associated with cardioembolism in some high-risk patient... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2120678 Thu, 22 Jan 2009 06:52:45 +0100 2120678 http://www.medworm.com/index.php?rid=2120676&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19151859%26dopt%3DAbstract Authors: Eichinger S A large number of hereditary and acquired alterations in the coagulation system that are associated with an increased risk of venous thrombosis have been described. Screening for these thrombophilic defects has become particularly popular in women before the prescription of oral contraceptives. The relevance of the results with regard to the management of the patients remains, however, to be questioned. In a recent review of six articles that were aimed to determine the nature and extent of psychological impact of thrombophilia screening, no valid conclusions could be drawn about the psychological impact due to heterogeneity of the data and lack of methodological accuracy. We performed a questionnaire-based study in 247 women with and in 132 women without factor V ... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2120676 Thu, 22 Jan 2009 06:52:37 +0100 2120676 http://www.medworm.com/index.php?rid=2120674&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19151861%26dopt%3DAbstract Authors: Sousou T, Khorana A Venous thromboembolism (VTE) is a known complication of cancer which impacts on patient mortality and quality of life. Despite the known deleterious effects of VTE, the benefits of thromboprophylaxis have not been fully established. Identification of patients at highest risk of VTE could lead to better targeting of thromboprophylaxis. Several risk factors have been identified as contributing to VTE such as site and stage of cancer, age, comorbidities, obesity, and acquired prothrombotic states. Anti-cancer agents as well as the use of growth factor support have also been implicated in VTE. Recent data have identified biomarkers such as blood counts, tissue factor and P-selectin. In this review, we briefly summarize the risk factors for VTE as well as candid... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2120674 Thu, 22 Jan 2009 06:52:30 +0100 2120674 http://www.medworm.com/index.php?rid=2120697&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19151838%26dopt%3DAbstract Hamostaseologie. 2009;29(1):1-2 Authors: Pabinger-Fasching I, Weltermann A PMID: 19151838 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2120697 Thu, 22 Jan 2009 06:52:27 +0100 2120697 http://www.medworm.com/index.php?rid=2120689&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19151846%26dopt%3DAbstract Authors: Toth B Emerging evidence suggests that circulating, cell-derived microparticles (MP) play a role in various physiological and pathophysiological processes. MP are involved in coagulation, inflammation and transportation. The role of circulating MP in the field of obstetrics and gynaecology has been investigated only recently. Healthy women show menstrual cycle-specific differences in circulating MP which differ significantly from age-matched men. With regard to obstetrics, MP were elevated in subgroups of patients with miscarriage or preeclampsia. Whether MP contribute to the pathogenesis of the diseases themselves is part of ongoing research. Moreover, recent studies indicate MP levels parallel tumor invasiveness in breast cancer patients and show similar sensitivity-specific... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2120689 Thu, 22 Jan 2009 06:52:27 +0100 2120689 http://www.medworm.com/index.php?rid=2120687&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19151848%26dopt%3DAbstract Authors: Albert FW, Eichler H, Haubelt H, Loreth R, Matzdorff A, Peetz D, Pindur G, Schinzel H, Seyfert U, Hellstern P, Haemorrhagic disorders must be excluded prior to any operation or other invasive procedure that has the potential to involve serious bleeding. When assessing the individual risk of bleeding, screening tests of hemostasis must be combined with the patient's clinical history and symptoms, and any history of bleeding must be explored under direct medical supervision using a standardized questionnaire. However, this bleeding history is neither very specific, nor is it particularly sensitive. Screening tests that have been found to be useful include platelet count, activated partial thrombo plastin time (aPTT), prothrombin time (PT) and clottable fibrinogen. No reliable, ... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2120687 Thu, 22 Jan 2009 06:52:27 +0100 2120687 http://www.medworm.com/index.php?rid=2120680&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19151855%26dopt%3DAbstract Authors: Deveber G The past decade has seen a dramatic increase in pediatric stroke research. However few studies have addressed antithrombotic safety or effectiveness. Three paediatric stroke guidelines combining research data with expert consensus have been published in the past five years. For most patients treatment recommendations are consistent. Newborns with arterial ischaemic stroke (AIS) rarely require antithrombotic treatment given their extremely low risk of recurrence. In children with AIS a substantial recurrence risk means that antithrombotic treatment is required unless contraindicated. Anticoagulation (heparins, warfarin) is recommended for possible or established dissection and cardiogenic embolism. Antiplatelet treatment is recommended for other children with AIS. For... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2120680 Thu, 22 Jan 2009 06:52:27 +0100 2120680 http://www.medworm.com/index.php?rid=2120679&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19151856%26dopt%3DAbstract Authors: Haas S, Bauersachs R Prevention of deep vein thrombosis has become standard of care in surgical and orthopaedic patients and it is gaining in attention in medical patients. However, there are still open questions related to its indication, to type and extent of prophylaxis and how to improve its efficacy and safety. In order to facilitate decision making to provide or to withhold prophylaxis, clinical risk assessment considering exposing and predisposing risk factors has proved to be of value. The exposing risk is characterised by type and extent of surgery or trauma, respectively, whereas the predisposing risk is determined by patient related risk factors. This has also been acknowledged in national and international guidelines. The choice of prophylactic modalities should be... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2120679 Thu, 22 Jan 2009 06:52:27 +0100 2120679 http://www.medworm.com/index.php?rid=2120677&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19151858%26dopt%3DAbstract Authors: Minar E Critical limb ischaemia (CLI) is a manifestation of peripheral arterial disease (PAD) that describes patients with chronic ischaemic rest pain, or patients with ischaemic skin lesions, either ulcers or gangrene. The clinical diagnosis of CLI should be confirmed by haemodynamic parameters such as the ankle- or toe systolic pressure. The estimated annual incidence of CLI ranges between 500 and 1 000 new cases per 1 million, with diabetes being the most important risk factor. CLI is also a marker for mostly generalized and severe atherosclerosis, and therefore the prognosis of patients is poor concerning overall survival. The primary goals of treatment in patients with CLI are to relieve ischaemic pain, heal ulcers, prevent limb loss, improve patient function and quality ... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2120677 Thu, 22 Jan 2009 06:52:27 +0100 2120677 http://www.medworm.com/index.php?rid=2120675&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19151860%26dopt%3DAbstract Authors: Lechner D, Weltermann A Epidemiological studies revealed that most antineoplastic agents and regimes enhance the risk of venous and arterial thromboembolic events in cancer patients. The purpose of this article is to review clinical and pathophysiological data related to chemotherapy-associated thromboembolism under special consideration of newer treatment strategies, such as angiogenesis inhibitors and immunmodulatory agents. Despite numerous clinical and experimental studies it has to be concluded that we are far from a comprehensive understanding of the pathogenesis of chemotherapy-associated thrombosis. PMID: 19151860 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2120675 Thu, 22 Jan 2009 06:52:27 +0100 2120675 http://www.medworm.com/index.php?rid=2112025&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19148616%26dopt%3DAbstract Authors: Zotz RB, Sucker C, Gerhardt A, Gohlke-Bärwolf C PMID: 19148616 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2112025 Sat, 17 Jan 2009 05:00:00 +0100 2112025 http://www.medworm.com/index.php?rid=2110179&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19132157%26dopt%3DAbstract Authors: Barthels M, Kemkes-Matthes B, Pötzsch B, Preissner KT, Riess H PMID: 19132157 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2110179 Mon, 01 Dec 2008 05:00:00 +0100 2110179 http://www.medworm.com/index.php?rid=2110178&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19132158%26dopt%3DAbstract Authors: Preissner KT The principles of initiator and amplifications reactions of blood coagulation and fibrinolysis will be presented and discussed in relation to various regulatory pathways of haemostasis. In particular, cell surface-dependent activation and inhibition reactions are characteristics of multicomponent enzyme complexes that also allow the endogenous control of the haemostasis system. The understanding of these relationships in complications of haemostasis has lead to different strategies for the therapeutic intervention with pro- and anticoagulant substances. PMID: 19132158 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2110178 Mon, 01 Dec 2008 05:00:00 +0100 2110178 http://www.medworm.com/index.php?rid=2110177&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19132159%26dopt%3DAbstract Authors: Mannhalter Ch Molecular biological methods have become increasingly important not only in the diagnostics of inherited monogenetic diseases such as hemophilia A or B but also in the diagnostics of polygenetic diseases e.g. venous and arterial thrombosis. In haemophilia A, sequencing of the factor VIII gene has been established in addition to the analysis of the two most frequent genetic abnormalities, the inversions in intron 22 and intron 1, in several centers. Molecular testing has proved helpful to identify haemophilia patients at high risk to develop inhibitors as well as in carrier analysis. In patients with familial protein C or protein S deficiency mutation analysis contributes to the verification of the diagnosis. The frequently performed tests for the factor V Leiden ... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2110177 Mon, 01 Dec 2008 05:00:00 +0100 2110177 http://www.medworm.com/index.php?rid=2110176&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19132160%26dopt%3DAbstract This article reviews the roles of blood platelets in haemostasis as well as in the pathogenesis of thromboembolic diseases. Besides the basic processes in primary haemostasis, platelet adhesion, platelet secretion, platelet aggregation, clot retraction, the new model of thrombin formation on the platelet surface is presented. The different signal transduction pathways in platelets are a main focus of this review. PMID: 19132160 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2110176 Mon, 01 Dec 2008 05:00:00 +0100 2110176 http://www.medworm.com/index.php?rid=2110175&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19132161%26dopt%3DAbstract Authors: Scharf RE Given the high consumption of pharmacological agents in western societies, it is not surprising at all that drugs represent the most common cause of acquired platelet dysfunction. While acetylsalicylic acid, clopigogrel and integrin alphaIIbbeta3 (GPIIb-IIIa) receptor antagonists are well-known as prototypes of antiplatelet drugs, other widely used agents including non-steroidal anti-inflammatory drugs, antibiotics, serotonin reuptake inhibitors, and volume expanders can also impair platelet function and cause or aggravate haemorrhages. Besides pharmacological agents, certain clinical conditions are often associated with qualitative platelet disorders and bleeding diathesis. Consequently, in contrast to inherited platelet disorders, acquired platelet function defects... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2110175 Mon, 01 Dec 2008 05:00:00 +0100 2110175 http://www.medworm.com/index.php?rid=2110174&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19132162%26dopt%3DAbstract Authors: Schneppenheim R, Budde U Von Willebrand disease (VWD) is known for its marked heterogeneity which was already recognized by von Willebrand in 1926. The basis of phenotypic differentiation are quantitative and qualitative or functional differences between the different types and subtypes of VWD. Clinical relevant facts for the practioner on diagnosis and therapy of von Willebrand disease and von Willebrand syndrome are presented. PMID: 19132162 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2110174 Mon, 01 Dec 2008 05:00:00 +0100 2110174 http://www.medworm.com/index.php?rid=2110173&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19132163%26dopt%3DAbstract Authors: Barthels M A survey is given on the peculiar characteristics of laboratory methods for analyzing the blood coagulation system with special regard to the preanalytical, analytical and postanalytical phase. Routinely used methods are described. PMID: 19132163 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2110173 Mon, 01 Dec 2008 05:00:00 +0100 2110173 http://www.medworm.com/index.php?rid=2110172&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19132164%26dopt%3DAbstract Authors: Oldenburg J, Barthels M An overview is given on the clinical picture and therapy of the haemophilias A and B as an example for congenital coagulopathies. The survey deals with the special problems of today's "treated haemophilia" and its recommendations on diagnosis and treatment regimens. A special focus is put on the pathogenesis of the haemophilic joint arthropathy, that is affecting most haemophiliacs earlier or later during life. Safe plasma derived and recombinant clotting factor concentrates allow an efficient on-demand and also a prophylactic treatment for the prevention of bleeding sequelae. As a consequence life quality and life expectancy of today born haemophiliacs have nearly normalised. The problems of haemophilia with inhibitors and future therapeutic options ar... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2110172 Mon, 01 Dec 2008 05:00:00 +0100 2110172 http://www.medworm.com/index.php?rid=2110171&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19132165%26dopt%3DAbstract Authors: Riess H Acquired coagulopathies regularly result from underlying diseases such as liver failure or sepsis. Optimal treatment of these underlying diseases defines longterm prognosis. In a few coagulopathies, such as immunocoagulopathies, in a relevant portion of patients an underlying disease cannot be identified. Therapeutic modulation of haemostasis aiming at the prevention of fatal bleeding or thromboembolism is able to improve the prognosis of patients with acquired coagulopathies. Most often this is the result of individualized, lab-controlled treatments, which are difficult to study. Within the last years the role of therapeutic modulation of haemostasis to reduce mortality was successfully studied for the first time in the frame of randomized placebo-controlled phase III... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2110171 Mon, 01 Dec 2008 05:00:00 +0100 2110171 http://www.medworm.com/index.php?rid=2110170&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19132166%26dopt%3DAbstract Authors: Studt JD Thrombotic microangiopathies are disorders of microvascular occlusion and are characterized by thrombocytopenia and microangiopathic haemolytic anaemia. Varying additional signs and symptoms of organ ischaemia may be present. Thrombotic microangiopathies are pathophysiologically heterogenous disorders and include primarily thrombotic thrombocytopenic purpura and haemolytic uraemic syndrome. Besides this, they may occur in association with certain diseases or drugs, or after allogeneic haematopoietic stem cell transplantation. PMID: 19132166 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2110170 Mon, 01 Dec 2008 05:00:00 +0100 2110170 http://www.medworm.com/index.php?rid=2110169&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19132167%26dopt%3DAbstract Authors: Lindhoff-Last E, Luxembourg B, Pabinger I A survey on definitions, epidemiology, clinical manifestations of congenital and acquired thrombophilias is given with focus on evidence-based data. Diagnostic and therapeutical strategies are presented. Selective thrombophilia screening based on previous personal and/or family history of venous thromboembolism is more cost-effective than universal screening in all patient groups. In the majority of patients with venous thrombosis the results of thrombophilia screening do not influence the duration of oral anticoagulation. The only patient population who clearly profits from thrombophilia screening in this situation are patients with a newly diagnosed antiphospholipid syndrome, because prolonged anticoagulation can avoid the high incid... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2110169 Mon, 01 Dec 2008 05:00:00 +0100 2110169 http://www.medworm.com/index.php?rid=2110168&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19132168%26dopt%3DAbstract Authors: Hach-Wunderle V In the diagnosis of deep vein thrombosis in ambulatory patients, the recommended initial steps are assessment of clinical probability (CP) and a sensitive D-dimer test. With a low CP and negative D-dimer, thrombosis can be ruled out. All other constellations require further investigation with imaging techniques. Compression ultrasonography is the first-line investigation. Low-molecular weight heparin or fondaparinux is the treatment of choice for uncomplicated venous thrombosis. Secondary prophylaxis with a vitamin K antagonist is introduced in parallel as quickly as possible. The duration of treatment depends on the exposure and predisposing factors, weighing carefully the risk of recurrence on the one hand against the risk of bleeding on the other. The danger... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2110168 Mon, 01 Dec 2008 05:00:00 +0100 2110168 http://www.medworm.com/index.php?rid=2110167&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19132169%26dopt%3DAbstract Authors: Barthels M, Oldenburg J Topics of this survey are the indications and use of plasma-derived and recombinant coagulation factor concentrates. These substitution therapies need to be handled carefully by weighing up their effectiveness against the long and short term side effects in the individual patient. PMID: 19132169 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2110167 Mon, 01 Dec 2008 05:00:00 +0100 2110167 http://www.medworm.com/index.php?rid=2110166&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19132170%26dopt%3DAbstract Authors: Alban S For decades, the options for therapeutic anticoagulation were limited to unfractionated heparin (UFH) and vitamin K antagonists (VKA), and their well-known limitations had to be accepted. With the introduction of the various LMWHs, the short- and medium-term anticoagulation could be much improved, but an alternative to VKA is still missing The heparins provided the proof of concept that FXa and thrombin represent suitable targets for therapeutic anticoagulation. Consequently, the search for new anticoagulants focuses on inhibitors of thrombin (DTI) or FXa (DXI). Apart from the VKA, the anticoagulants presently available or in an advanced stage of development can thus be divided in two classes: One are the glyco-anticoagulants with the natural sulfated glycosaminoglycan... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2110166 Mon, 01 Dec 2008 05:00:00 +0100 2110166 http://www.medworm.com/index.php?rid=2110165&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19132171%26dopt%3DAbstract Authors: Kemkes-Matthes B A survey is given on pharmacology and indications for the treatment with vitamin K antagonists. The therapeutic handling and self control by the patient is described. PMID: 19132171 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2110165 Mon, 01 Dec 2008 05:00:00 +0100 2110165 http://www.medworm.com/index.php?rid=2110164&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19132172%26dopt%3DAbstract This article presents the most common fibrinolytic agents as well as evidences and recommendations for fibrinolytic therapy of different vascular regions. PMID: 19132172 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2110164 Mon, 01 Dec 2008 05:00:00 +0100 2110164 http://www.medworm.com/index.php?rid=2110163&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19132173%26dopt%3DAbstract Authors: Schwarz M, Saurbier B, Bode C The term acute coronary syndrome (ACS) pertains to the instable and life-threatening forms of a clinically manifest coronary artery disease with biochemical and/or electro-cardiographic evidence of myocyte cell death. In detail, it includes the unstable angina pectoris, the non-ST segment elevation myocardial infarction (NSTEMI) the ST segment elevation myocardial infarction (STEMI) and as well the sudden cardiac death. As early reperfusion of ischaemic myocardium is the most effective way for limiting infarct size by restoring the balance between myocardial oxygen supply and demand, it is the most important therapeutic goal to achieve early and complete antegrade flow in the occluded or restricted vessel, related with a reduction of short and lon... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2110163 Mon, 01 Dec 2008 05:00:00 +0100 2110163 http://www.medworm.com/index.php?rid=2110162&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19132174%26dopt%3DAbstract Authors: Korte W Managing perioperative haemostasis starts with the diligently taken patient history. Unfortunately, classic global tests such as the PT and aPTT have no predictive value with regard to an acquired intra- or postoperative bleeding diathesis. However, new assays for preoperative risk stratification are in clinical development. An attribute of good perioperative haemostasis management is the early, multidisciplinary problem assessment. With a preoperatively existing anticoagulation or antiplatelet therapy, perioperative bridging therapy needs to be carefully planned as cardiovascular risk patients have an increased risk of morbidity and mortality when their current anticoagulative therapy is simply stopped. If a haemorrhagic diathesis is known, a specific therapy should b... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2110162 Mon, 01 Dec 2008 05:00:00 +0100 2110162 http://www.medworm.com/index.php?rid=2110161&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19132175%26dopt%3DAbstract Authors: Zotz RB, Sucker C, Gerhardt A Women with acquired and hereditary thrombophilia are at increased risk of developing venous thromboembolism and other associated gestational vascular complications like fetal loss, preeclampsia, intrauterine growth restriction, and placental abruption during pregnancy. These complications are a major cause of maternal and fetal morbidity and mortality. In view of the data showing an association between thrombophilia and these adverse pregnancy outcomes, clinicians are increasingly using antithrombotic therapy in women at risk of these complications. Aside from recurrent pregnancy loss in antiphospholipid syndrome and prevention of venous thromboembolism, there is limited evidence on the benefit of antithrombotic interventions to guide therapy. The... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2110161 Mon, 01 Dec 2008 05:00:00 +0100 2110161 http://www.medworm.com/index.php?rid=2110160&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19132176%26dopt%3DAbstract Authors: Kurnik K As in adults, haemorrhagic or thrombotic events may also occur in children. The underlying reasons are inborn or acquired. Inherited disorders usually present during in early infancy. In order to interpret clinical and laboratory findings in children, it is necessary to keep in mind some specific paediatric features. This knowledge also forms the basic requirement to choose the appropriate therapy. PMID: 19132176 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2110160 Mon, 01 Dec 2008 05:00:00 +0100 2110160 http://www.medworm.com/index.php?rid=2110159&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19132177%26dopt%3DAbstract This article provides an overview on the significance, pathogenesis and treatment of cancer-related clotting disorders as well as on the cellular and molecular mechanisms, by which haemostatic components such as TF, platelets and fibrin(ogen) drive tumour progression. PMID: 19132177 [PubMed - in process] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=2110159 Mon, 01 Dec 2008 05:00:00 +0100 2110159 http://www.medworm.com/index.php?rid=1859038&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18836641%26dopt%3DAbstract Hamostaseologie. 2008;28(4):185 Authors: Mondorf W PMID: 18836641 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1859038 Wed, 08 Oct 2008 11:22:51 +0100 1859038 http://www.medworm.com/index.php?rid=1859037&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18836642%26dopt%3DAbstract Hamostaseologie. 2008;28(4):187 Authors: Moser M, Bode C PMID: 18836642 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1859037 Wed, 08 Oct 2008 11:22:51 +0100 1859037 http://www.medworm.com/index.php?rid=1859036&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18836643%26dopt%3DAbstract Authors: Moser M The formation of vasculature is a key step during embryogenesis. The vasculature and the intravascular blood compartment, which uses the former as a means of transportation, develop in a close spatial and temporal relationship. This review discusses the role of the blood coagulation system, particularly thrombin, as a tool to coordinate blood vessel formation. Mouse models indicate that a lack of coagulation factors results in impaired thrombin generation and consequently display a phenotype of disturbed cardiovascular development. Similar phenotypes are present in mouse models of impaired thrombin binding to its cellular receptor PAR1 or of disrupted signaling via G-proteins. Moreover, there is compelling evidence that thrombin signaling in vascular development cannot... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1859036 Wed, 08 Oct 2008 11:22:51 +0100 1859036 http://www.medworm.com/index.php?rid=1859035&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18836644%26dopt%3DAbstract Authors: Grundmann S, Hoefer I, Bode C The stimulation of the endogenous adaptive vessel growth (angiogenesis, arteriogenesis) provides a promising therapeutic approach for the large number of patients with vascular occlusive disease that is not eligible for current interventional treatments. Despite the proven efficacy of various factors in pre-clinical experimental studies, the successful translation of angiogenic therapies into clinical practice yet remains to be made. Most authors identified the mode of administrations as culprit for the neutral effects observed in the majority of clinical trials. Although experimental studies have proven the superiority of continuous intra-arterial application above other routes (iv, im, sc), clinical trials focused on either bolus therapy, iv or ... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1859035 Wed, 08 Oct 2008 11:22:51 +0100 1859035 http://www.medworm.com/index.php?rid=1859034&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18836645%26dopt%3DAbstract Authors: Diehl P, Helbing T, Bode C, Moser M Microparticles (MP) are small cell vesicles that are released by activated or apoptotic cells and that are amenable to quantification in peripheral blood. MP consist of the cytoplasm and the cell membrane of their cell of origin, which allows for their assignment to these cells. By the detection of the respected MP one can conclude to the functional status of the cell of origin. It is known that MP confer specific information between cells and contribute to inflammatory and coagulatory processes. They are detectable in many acute and chronic vascular diseases as a surrogate marker for disease activity but also play a role in the pathophysiology of vascular diseases. PMID: 18836645 [PubMed - as supplied by publisher] (Source: Hamostaseolo... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1859034 Wed, 08 Oct 2008 11:22:51 +0100 1859034 http://www.medworm.com/index.php?rid=1859033&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18836646%26dopt%3DAbstract Authors: Freestone B, Lip GY Atrial fibrillation (AF) is the commonest sustained cardiac arrhythmia, which confers a high risk of mortality and morbidity from stroke and thromboembolism. The precise mechanisms by which AF causes thromboembolism and subsequent cerebrovascular events have attracted much research interest, and are yet to be fully elucidated. Nonetheless, it is well recognised that AF fulfils Virchow's triad for thrombogenesis, with abnormal flow conditions with loss of atrial contractility and an irregularly irregular cardiac output, (i. e. flow abnormalities), as well as structural heart disease with endocardial damage (i. e. abnormal vessel wall) and abnormalities in platelet and haemostatic variables (i. e. abnormal blood constituents). This review is to summarise the ... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1859033 Wed, 08 Oct 2008 11:22:51 +0100 1859033 http://www.medworm.com/index.php?rid=1859032&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18836647%26dopt%3DAbstract Authors: Schwarz M, Bode C In this overview the actual guideline-recommendations for anticoagulation in atrial fibrillation and the problems of the currently available therapy are discussed. Furthermore an outlook over future developments in this field is given. Effective anticoagulation can prohibit thrombembolic events and is thus essential for the prognosis of patients suffering from atrial fibrillation. Until now vitamin-K-antagonists (VKAs) and acetylsalicylic acid (ASA) are available for oral anticoagulation in these patients. VKAs demonstrate a satisfying efficiency combined with rather high bleeding hazard. ASA on the other hand allows only moderate risk reduction with minimal side effects. Thus the guidelines recommend anticoagulation tailored to the individual risk, which can... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1859032 Wed, 08 Oct 2008 11:22:51 +0100 1859032 http://www.medworm.com/index.php?rid=1859031&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18836648%26dopt%3DAbstract Authors: Hochauf S, Beyer J Most hospitalized patients present risk factors for venous thromboembolism (VTE). Deep vein thrombosis and pulmonary embolism are relevant causes for morbidity and mortality in the perihospital phase, with a possibly fatal outcome. Surgical as well as nonsurgical patients with acute medical illness are at risk and show comparatively high rates of VTE. Because of this, an effective and safe prophylaxis for hospitalized patients is necessary. Definition of different risk categories and treatment of patients according to the individual risk profile is standard in VTE prophylaxis. For VTE prophylaxis various medical and mechanical options are available. PMID: 18836648 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1859031 Wed, 08 Oct 2008 11:22:51 +0100 1859031 http://www.medworm.com/index.php?rid=1859030&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18836649%26dopt%3DAbstract Authors: Grünig E, Ehlken N, Nagel C In pulmonary arterial hypertension (PAH), thrombosis and thromboembolism occurs as a consequence of pulmonary microvasculopathy with a change of pulmonary vascular microenviroment toward a procoagulant, prothrombotic and antifibrinolytic pattern. Circulating antiphospholipid antibodies, increased plasma levels of platelet aggregating agents (serotonin, thromboxane), adhesion molecules (P selectin, von Willebrand factor), antifibrinolytic enzymes (plasminogen activator inhibitor 1) and prothrombotic cytokines have been identified in PAH patients so far. Thrombogenic pulmonary vasculopathy has been documented in many patients with PAH. Furthermore, most patients will not be diagnosed until right heart enlargement and impaired right ventricular fu... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1859030 Wed, 08 Oct 2008 11:22:51 +0100 1859030 http://www.medworm.com/index.php?rid=1859029&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18836650%26dopt%3DAbstract Authors: Völler H, Braun S Nearly every second patient, who needs an oral anticoagulation with vitamin K antagonists, is feasible to perform INR-selfmanagement after participation in a structured teaching program. Patient self-testing or measuring the INR value by relatives or nurses would increase this method of control by the aid of telemedicine systems. An accurately, weekly measurement leads to an optimal therapeutic control of anticoagulation intensity, which results in an impressive risk reduction up to 50%. This depends not on the underlying heart disease and had been demonstrated in patients older than 60 years. Due to the small INR variability and therefore a higher percentage in target range, a lower anticoagulation intensity in patients with mechanical heart valve prost... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1859029 Wed, 08 Oct 2008 11:22:51 +0100 1859029 http://www.medworm.com/index.php?rid=1859028&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18836651%26dopt%3DAbstract Authors: Pech M, Meyer F, Halloul Z Interventional radiology has an increasing spectrum of indications, in particular, for vascular medical problems. By Seldinger's puncture via the right femoral artery, an aneurysm of the right common iliac artery stump was sufficiently excluded with coil embolization. As a complication, an iatrogenic bleeding at the aneurysmatic neck was effectively stopped after the first interventional step with injection of an occlusion emulsion according to the bleeding site. Image-guided interventional measures in radiology allow a minimal invasive approach in a former classical field of vascular surgery. Furthermore, procedure-related complications can be increasingly controlled. PMID: 18836651 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1859028 Wed, 08 Oct 2008 11:22:51 +0100 1859028 http://www.medworm.com/index.php?rid=1768212&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18768435%26dopt%3DAbstract CONCLUSION: Donor type is not a major prognostic factor for HCT in elderly patients with standard- or high-risk AML. PMID: 18768435 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1768212 Tue, 02 Sep 2008 04:00:00 +0100 1768212 http://www.medworm.com/index.php?rid=1634513&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18629501%26dopt%3DAbstract Authors: Wolf HH, Leithäuser M, Maschmeyer G, Salwender H, Klein U, Chaberny I, Weissinger F, Buchheidt D, Ruhnke M, Egerer G, Cornely O, Fätkenheuer G, Mousset S Catheter-related infections (CRI) cause considerable morbidity in hospitalized patients. The incidence does not seem to be higher in neutropenic patients than in nonneutropenic patients. Gram-positive bacteria (coagulase-negative staphylococci, Staphylococcus aureus) are the pathogens most frequently cultured, followed by Candida species. Positive blood cultures are the cornerstone in the diagnosis of CRIs, while local signs of infection are not necessarily present. Blood cultures should be taken from peripheral blood and from the venous catheter. A shorter time to positivity of catheter blood cultures as compared w... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1634513 Wed, 16 Jul 2008 04:00:00 +0100 1634513 http://www.medworm.com/index.php?rid=1491629&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18521486%26dopt%3DAbstract Authors: Eichinger S PMID: 18521486 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1491629 Wed, 04 Jun 2008 15:19:56 +0100 1491629 http://www.medworm.com/index.php?rid=1491628&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18521487%26dopt%3DAbstract Authors: Dahlbäck B Venous thrombosis is a major medical problem annually affecting millions of individuals worldwide. It is a typical multifactorial disease, the pathogenesis involving both environmental and genetic risk factors. A single point mutation in the gene of coagulation factor V (FV), which results in the replacement of Arg506 with a Gln (FV Leiden) is the most common genetic risk factor known to date. The anticoagulant activated protein C (APC) regulates the activity of FVa by cleaving several sites in FVa, and the Arg506 is one of them. APC resistance, which is the consequence of the FV Arg506Gln mutation, results a lifelong hypercoagulable state that increases the risk of thrombosis. APC resistance was discovered in my laboratory and the first paper was published in ... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1491628 Wed, 04 Jun 2008 15:19:56 +0100 1491628 http://www.medworm.com/index.php?rid=1491627&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18521488%26dopt%3DAbstract Authors: Schulman S Whereas every clinician agrees on the need for anticoagulation initially after the diagnosis of venous thromboembolism (VTE), the opinions regarding optimal duration of secondary prophylaxis differ. The decision is complicated by the large number of identified risk factors associated with the risk of recurrence. In addition consideration has to be taken to the risk factors for bleeding and individual patient preferences. Data from long-term follow-up studies up to a decade indicate that some risk factors for recurrence decline and others seem to gain importance with time. In this review data has been extracted from the most illustrative trials to highlight controversies but also where there is consensus in order to give the clinician some support for the individual ... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1491627 Wed, 04 Jun 2008 15:19:56 +0100 1491627 http://www.medworm.com/index.php?rid=1491626&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18521489%26dopt%3DAbstract Authors: Zotz RB Thrombophilic risk factors of the vascular system are not as well defined as the classic risk factors of atherosclerosis or the thrombophilic risk factors of the venous system. Until now, the assessment is complicated by an inadequate differentiation between (a) proatherosclerotic and prothrombogenic effects (i. e. platelet receptor polymorphisms) and (b) reactive alterations of a haemostatic parameter (i. e. PAI-1, Fibrinogen) as an expression of an acute phase reaction and primary hereditary changes of those risk determinants. Actual data indicate for the majority of the potential risk factors only a mildly increased relative risk for an arterial ischaemic event and are often inconsistent. Anyhow, the impact of potential thrombophilic risk factors for the arterial va... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1491626 Wed, 04 Jun 2008 15:19:56 +0100 1491626 http://www.medworm.com/index.php?rid=1491625&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18521490%26dopt%3DAbstract CONCLUSION: Thrombophilia screening might be justified in women with pregnancy loss. Treatment with low molecular weight heparin might be considered for those with pregnancy loss and thrombophilia. Further prospective studies and controlled interventional trials are urgently needed. PMID: 18521490 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1491625 Wed, 04 Jun 2008 15:19:56 +0100 1491625 http://www.medworm.com/index.php?rid=1491624&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18521491%26dopt%3DAbstract Authors: Lammers T, Schambeck CM For thrombophilia should be screened, if a first thromboembolic event has occurred at the age of less than 45 years, if family history indicates thrombophilia, or in the case of a special clinical condition. To get valid diagnostic results a few pecularities concerning the physiology of coagulation and laboratory medicine have to be considered. This review gives an overview of pitfalls and options during the preanalytical phase of thrombophilia diagnostics. Furthermore, the laboratory assays to perform a screening are highlighted. PMID: 18521491 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1491624 Wed, 04 Jun 2008 15:19:55 +0100 1491624 http://www.medworm.com/index.php?rid=1491623&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18521492%26dopt%3DAbstract This article discusses the complexity of laboratory testing, problems of its standardisation and interpretation of test results. Progress and limitations of laboratory analysis are compared and the clinician will learn to read lab results with caution. PMID: 18521492 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1491623 Wed, 04 Jun 2008 15:19:55 +0100 1491623 http://www.medworm.com/index.php?rid=1491622&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18521493%26dopt%3DAbstract CONCLUSION: Our data allow an overview of the number of patients and treatment strategies in the eastern part of Germany. PMID: 18521493 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1491622 Wed, 04 Jun 2008 15:19:55 +0100 1491622 http://www.medworm.com/index.php?rid=1445576&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18478507%26dopt%3DAbstract Authors: Jurk K, Kehrel BE The views on the role of platelets in physiology and in pathogenesis have considerably changed in the recent past. While platelets had previously been seen only as contributors in primary haemostasis and as donors of negatively charged phospholipids to support thrombin formation, this view has had to be revised, at least since the discovery of specific receptors for coagulation factors on the platelet surface. Platelets are part of the body's immune defence system. They can interact with bacteria, pathogenic fungi and protozoa. The interaction of platelets with endothelial cells and leukocytes is crucial in innate and adaptive immunity. Platelets participate in the pathogenesis of the initial lesions and in the progression of atherosclerosis by inducing chron... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1445576 Thu, 01 May 2008 04:00:00 +0100 1445576 http://www.medworm.com/index.php?rid=1351422&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18386010%26dopt%3DAbstract Authors: Buchholz S, Dammann E, Koenecke C, Stadler M, Franzke A, Blasczyk R, Bremer M, Krauter J, Hertenstein B, Ganser A, Eder M Aplastic anaemia (AA) is a rare bone marrow failure syndrome treated either by immunosuppressive therapy or allogeneic stem cell transplantation (SCT). At present, no randomised clinical trials evaluating both treatment options, and in particular SCT from unrelated donors, are available. We here report the clinical course and outcome of allogeneic SCT for 20 consecutive adult patients with AA. Newly diagnosed and untreated patients (n = 8) or patients pre-treated by immunosuppressive therapy (n = 12) were transplanted either from human-leukocyte-antigen (HLA) identical family donors (n = 13) or matched (n = 6) and mismatched (n = 1) unrelated donors, respec... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1351422 Thu, 03 Apr 2008 04:00:00 +0100 1351422 http://www.medworm.com/index.php?rid=1241459&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18278154%26dopt%3DAbstract Hamostaseologie. 2008;28(1):1-3 Authors: Preissner KT PMID: 18278154 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1241459 Tue, 19 Feb 2008 20:43:57 +0100 1241459 http://www.medworm.com/index.php?rid=1241458&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18278155%26dopt%3DAbstract Hamostaseologie. 2008;28(1):7 Authors: Hueber J PMID: 18278155 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1241458 Tue, 19 Feb 2008 20:43:57 +0100 1241458 http://www.medworm.com/index.php?rid=1241457&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18278156%26dopt%3DAbstract Authors: Hilberg T Life expectancy can be increased by life style changes such as improvement of nutrition habits and by physical activities. The relevance of physical activity for the prevention of cardiovascular diseases, especially coronary artery disease, is supported by several epidemiological studies. These data show a clear reduction by 35% in total as well as in cardiovascular-related mortality risk, due to primary prevention by physical activity. Within the secondary prevention, additional physical exercise leads to a marked decrease by 27% in the total, and by 31% in the cardiovascular-related mortality. This is due to improvement of the cardiovascular risk profile, including arterial blood pressure, lipid profile, type 2 diabetes, obesity as secondary effects. However, of pa... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1241457 Tue, 19 Feb 2008 20:43:57 +0100 1241457 http://www.medworm.com/index.php?rid=1241456&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18278157%26dopt%3DAbstract Authors: Nowak-Göttl U, Kurnik K, Krümpel A, Stoll M Venous thromboembolism (VTE) is a rare disease that is being increasingly diagnosed and recognized in paediatrics in the past decade, usually as a secondary complication of primary severe underlying diseases. Apart from acquired thrombophilic risk factors, such as lupus anticoagulants, inherited thrombophilias (IT) have been established as risk factors for venous thromboembolic events in adults. In children with idiopathic VTE and in paediatric populations in which thromboses were associated with underlying medical diseases, IT have been described as additional prothrombotic risk factors. Follow-up data for VTE recurrence in children are available and suggest a recurrence rate of approximately 3% in neonates and 8% in other... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1241456 Tue, 19 Feb 2008 20:43:57 +0100 1241456 http://www.medworm.com/index.php?rid=1241455&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18278158%26dopt%3DAbstract Authors: Bauersachs RM This review updates the latest developments concerning new anticoagulants. It describes potential targets in the coagulation pathway: inhibition of the initiation of coagulation, factor Xa and thrombin inhibitors. The focus is laid on substances in late development that already passed the phase II trial for venous thromboembolism (VTE)-prevention as "proof of concept". In the group of factor Xa inhibitors, the indirect inhibitor Fondaparinux has got approval for the indications prevention and therapy of VTE and acute coronary syndromes (OASIS 5 and 6). Rivaroxaban is the first direct factor Xa inhibitor that was admitted for approval in the indication VTE-prevention. The first trial of the program RECORD 1-4 was finished, trials for the indications therapy of VTE... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1241455 Tue, 19 Feb 2008 20:43:57 +0100 1241455 http://www.medworm.com/index.php?rid=1241454&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18278159%26dopt%3DAbstract Authors: Ruppert C, Markart P, Wygrecka M, Preissner KT, Günther A Elevated procoagulant and suppressed fibrinolytic activities are regularly encountered in different forms of clinical and experimental fibrosis of the lungs and the kidneys. Although primarily serving to provide a provisional matrix of repair largely consisting of fibrin and fibronectin, the involved procoagulant serine proteases and protease inhibitors may also exert distinct cellular downstream signaling events modifying the fibrotic reponse. In this review, evidence for an impaired regulation of coagulation and fibrinolysis factors in clinical and experimental lung and renal fibrosis is provided and the role of PAR (protease activated receptor) induced profibrotic and HGF (hepatocyte growth factor) elicited anti... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1241454 Tue, 19 Feb 2008 20:43:57 +0100 1241454 http://www.medworm.com/index.php?rid=1241453&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18278160%26dopt%3DAbstract Authors: Eichinger S Venous thromboembolism is a chronic and potential fatal disease. Determination of recurrence risk is time-consuming and costly, and sometimes not feasible: many patients carry more than one risk factor, the relevance of some factors with regard to risk of recurrence is unknown, and existence of thus far unknown risk factors must be considered. A laboratory assay that measures multifactorial thrombophilia would be useful to identify patients at risk of thrombosis. The process of thrombin generation is the central event of the hemostatic process. Thrombin generation is increased in patients at risk of thrombosis including those with antithrombin deficiency or those who are taking hormonal contraceptives. Risk of first and recurrent venous thrombosis is higher in pati... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1241453 Tue, 19 Feb 2008 20:43:57 +0100 1241453 http://www.medworm.com/index.php?rid=1241452&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18278161%26dopt%3DAbstract Authors: Humenberger M, Lang IM The underlying disorder of pulmonary embolism (PE) is venous thromboembolism (VTE), comprising deep vein thrombosis, thrombus in transit, acute pulmonary embolism and chronic thromboembolic pulmonary hypertension (CTEPH). PE may recur and cause serious long-term complications, such as post-thrombotic syndrome and CTEPH. This short overview summarizes current concepts on pathophysiology, epidemiology, diagnosis and treatment of this common disorder. PMID: 18278161 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1241452 Tue, 19 Feb 2008 20:43:57 +0100 1241452 http://www.medworm.com/index.php?rid=1241451&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18278162%26dopt%3DAbstract Authors: Oldenburg J, Seidel H, Pötzsch B, Watzka M The recent identification of vitamin K epoxid-reductase complex (VKORC1) contributed significantly to our mechanistic understanding of the vitamin K cycle. VKORC1 protein is targeted by Coumarins. Its enzymatic activity represents the rate-limiting step in the vitamin K cycle and gamma-carboxylation of vitamin K dependent proteins. Possibly, VKORC1 is the only component of VKOR activity. Mutations as well as polymorphisms in coding and non-coding regions of the VKORC1 gene have been shown to cause both partial to total coumarin resistance and coumarin sensitivity. Availability of molecular diagnostics (VKORC1, CYP2C9) and laboratory analysis by HPLC (determination of coumarin, vitamin K and vitamin K epoxide levels) is helpful in... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1241451 Tue, 19 Feb 2008 20:43:57 +0100 1241451 http://www.medworm.com/index.php?rid=1241450&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18278163%26dopt%3DAbstract Authors: Alban S For several decades, anticoagulants based on glycosaminoglycans (GAG) are drugs of choice in the therapy and prophylaxis of thromboembolic diseases. In principle, it has to be differentiated between the natural GAG-anticoagulants, which are molecular mixtures with complex composition, and the synthetic GAG-anticoagulants, which are chemically defined oligosaccharides. The former include unfractionated heparin, the various low molecular weight heparins and danaparoid. Representatives of the second group are fondaparinux, idraparinux and the hexadecasaccharide SR123781A. They share a common mechanism of action together with the endogenous antithrombotic heparan sulfate, i.e. the catalysis of the antithrombin-mediated inhibition of factor Xa. Besides, considerable structu... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1241450 Tue, 19 Feb 2008 20:43:57 +0100 1241450 http://www.medworm.com/index.php?rid=1241449&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18278164%26dopt%3DAbstract Authors: Moser M, Bode C The acute coronary syndrome (ACS) is one of the most frequent diagnoses in cardiology. The therapeutic corner-stones of ACS are PCI (percutaneous coronary intervention) and inhibition of blood coagulation. Current antiplatelet therapy consists of aspirin in combination with clopidogrel and glycoprotein IIb/IIIa blockade if needed. Prasugel is a new antiplatelet agent that is in the process of being approved for routine clinical use. In terms of antithrombotic therapy latest developments focus on drugs with anti-factor Xa activity, such as fondaparinux, or direct anti-thrombin activity, such as bivalirudin. This review discusses latest developments in the field of anti-platelet and anti-thrombotic therapy for ACS. PMID: 18278164 [PubMed - as supplied by publ... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1241449 Tue, 19 Feb 2008 20:43:57 +0100 1241449 http://www.medworm.com/index.php?rid=1241448&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18278165%26dopt%3DAbstract Authors: Weber AA, Adamzik M, Bachmann HS, Görlinger K, Grandoch M, Leineweber K, Müller-Beißenhirtz H, Wenzel F, Naber C, Based on the concept that the so-called resistance to anti-platelet drugs is meant to describe a phenomenon where the drug does not hit its direct pharmacodynamic target, assays, used to evaluated the effects of anti-platelet drugs, should as closely as possible measure the direct pharmacodynamic effect of a particular drug. Thus, for the detection of aspirin effects, thromboxane concentrations or arachidonic acid-induced responses (light aggregometry, whole-blood aggregometry) should be measured. For the detection of clopidogrel actions, VASP phosphorylation (flow cytometry) or ADP-induced responses (light aggregometry, whole blood aggregometry) sh... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1241448 Tue, 19 Feb 2008 20:43:57 +0100 1241448 http://www.medworm.com/index.php?rid=1241447&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18278166%26dopt%3DAbstract Authors: Sachs UJ Idiopathic thrombocytopenic purpura (ITP) has an incidence of 5.8-6.6 per 100 000 adults and represents a frequent cause of impaired cellular haemostasis in clinical practice. Its diagnosis is still one of exclusion, because the diagnostic value of proposed biological markers of the disease has been disputed. The potential contribution of biomarkers both of the autoimmune reaction (leptin, free and cell-bound anti-platelet autoantibodies, specific B cells) and of thrombopoiesis (bone marrow histology, thrombopoietin, glycocalicin, reticulated platelets) to the diagnosis of ITP will be discussed. There is evidence that some of these biomarkers indeed could be useful in the diagnosis of ITP. To cope with the rapid progress in ITP therapy, prospective studies on well cha... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1241447 Tue, 19 Feb 2008 20:43:57 +0100 1241447 http://www.medworm.com/index.php?rid=1241446&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18278167%26dopt%3DAbstract Authors: Aleksandrowicz P, Wolf K, Falzarano D, Feldmann H, Seebach J, Schnittler H Pathogenesis of viral haemorrhagic fever (VHF) is closely associated with alterations of the vascular system. Among the virus families causing VHF, filoviruses (Marburg and Ebola) are the most fatal, and will be focused on here. After entering the body, Ebola primarily targets monocytes/macrophages and dendritic cells. Infected dendritic cells are largely impaired in their activation potency, likely contributing to the immune suppression that occurs during filovirus infection. Monocytes/macrophages, however, immediately activate after viral contact and release reasonable amounts of cytokines that target the vascular system, particularly the endothelial cells. Some underlying molecular mechanisms such as... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1241446 Tue, 19 Feb 2008 20:43:57 +0100 1241446 http://www.medworm.com/index.php?rid=1241445&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18278168%26dopt%3DAbstract Conclusion: By proteome analysis protein targets were identified in vitro in endothelial cells that respond to soy isoflavones and that may decipher molecular mechanisms through which soy products exert their protective effects in the vasculature. PMID: 18278168 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1241445 Tue, 19 Feb 2008 20:43:57 +0100 1241445 http://www.medworm.com/index.php?rid=1118144&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18157609%26dopt%3DAbstract Authors: Pabinger I, Eichinger S, Minar E, Niessner H Venous thromboembolism occurs in a significant number of patients in typical risk situations (e.g. surgery or trauma). However, in these special highrisk situations anticoagulants, particularly low molecular weight heparin, allow for a decrease in the number of venous thromboses, pulmonary embolisms and deaths caused by pulmonary embolism. Only the wide-spread and adequate use of antithrombotics can safeguard against venous thromboembolism in these various risk situations. Guidelines constitute an integrative part of quality management and ensure the application of evidence-based medicine. The present consensus on thrombosis prophylaxis in Austria has been elaborated by 23 experts in the fields of hemostasis research, angiology, sur... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1118144 Thu, 27 Dec 2007 13:23:44 +0100 1118144 http://www.medworm.com/index.php?rid=1079354&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18060239%26dopt%3DAbstract Hamostaseologie. 2007;27(5):317 Authors: Bode C PMID: 18060239 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1079354 Sat, 08 Dec 2007 01:34:59 +0100 1079354 http://www.medworm.com/index.php?rid=1079353&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18060240%26dopt%3DAbstract Authors: Hölschermann H Recent advances in the diagnosis and the treatment of acute coronary syndromes (ACS) have led to a substantial reduction of major coronary events, to an improvement in patient outcome and the definition of new guidelines. Current strategies for the treatment of patients with non-ST-elevation ACS recommend a combined antithrombotic therapy (including aspirin, clopidogrel, anticoagulation with low-molecular weight or unfractionated heparins or FXa-inhibitors or direct antithrombins and, eventually glycoprotein IIb/IIIa receptor antagonists). This combined antithrombotic therapy allows to increase the benefit of an early invasive strategy including coronary angiogram with stent percutaneous coronary angioplasty. The purpose of this review is to discuss and hig... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1079353 Sat, 08 Dec 2007 01:34:59 +0100 1079353 http://www.medworm.com/index.php?rid=1079352&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18060241%26dopt%3DAbstract Authors: Ahrens I, Peter K, Bode C The recently established correlation between bleeding events and clinical outcomes in patients with coronary artery disease undergoing either non-invasive or invasive treatment for acute coronary syndromes (ACS) highlights the unmet need for safer anticoagulants that can be used in conjunction with dual or triple antiplatelet therapy. The central position of the coagulation factors IIa and Xa within the coagulation system account for their prominent role as targets for anticoagulants. Unfractionated heparin (UFH) achieves a variable indirect inhibition of both factors. The low molecular weight heparins (LMWH) show favourable pharmacokinetics over UFH and have a more pronounced activity against factor Xa as opposed to thrombin which may partially accou... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1079352 Sat, 08 Dec 2007 01:34:59 +0100 1079352 http://www.medworm.com/index.php?rid=1079351&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18060242%26dopt%3DAbstract Authors: Heinze H, Darius H The direct thrombin inhibitor bivalirudin was tested in the ACUITY Trial 13 819 patients with acute non-ST-segment elevation coronary syndrome in a prospective and randomized design. Three therapeutic regimens were compared in the context of an early invasive strategy: heparin plus glycoprotein IIb/IIIa inhibitor (GPI), bivalirudin plus GPI, or bivalirudin alone. Concerning the rate of ischaemic events bivalirudin alone was comparable to heparin plus GPI at a significantly lower rate of bleeding complications. PMID: 18060242 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1079351 Sat, 08 Dec 2007 01:34:59 +0100 1079351 http://www.medworm.com/index.php?rid=1079350&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18060243%26dopt%3DAbstract Authors: Bigalke B, Lindemann S, Gawaz M Platelets play a critical role in formation of coronary thrombosis. An enhanced systemic platelet activation plays a significant role in the acute coronary syndrome. Despite better interventional techniques and better concomitant pharmacological therapy, the degree of platelet activation contributes significantly to prognosis and postinterventional event rate. Residual platelet activation after intervention is often associated with an enhanced initial platelet activation prior interventional treatment. An effective antiplatelet therapy is of utmost importance for the acute therapy and for secondary prevention in patients undergoing coronary interventions or with acute coronary syndrome. The efficacy of the antithrombotic therapy determines the l... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1079350 Sat, 08 Dec 2007 01:34:59 +0100 1079350 http://www.medworm.com/index.php?rid=1079349&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18060244%26dopt%3DAbstract Authors: Grumann T, Diehl P, Bode C, Moser M Coronary stents are the mainstay of percutaneous coronary intervention. Stent thrombosis is a potentially catastrophic and often life-threatening complication. If it occurs it presents in up to 80% as myocardial infarction, about half of the affected patients die from this complication. The dual antiplatelet therapy has markedly reduced its occurrence. Today, stent thrombosis occurs in <1%, usually as a delayed event; but compared to bare metal stents the overall incidence has not increased in metaanalyses of randomized trials. The advent of drug-eluting stents (DES) has raised concerns regarding the occurrence of delayed stent thrombosis. Delayed arterial wall healing as well as prothrombotic characteristics of the drug eluting stent its... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1079349 Sat, 08 Dec 2007 01:34:59 +0100 1079349 http://www.medworm.com/index.php?rid=1079348&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18060245%26dopt%3DAbstract Authors: Schrör K, Huber K The introduction of thienopyridines, specifically of clopidogrel, offered for the first time an orally active therapeutic alternative to acetylsalicylic acid (ASA) as an antiplatelet agent. Despite of established clinical efficacy, it became also evident with increasing clinical use that the antiplatelet actions of clopidogrel are subject of considerable interindividual variations of its antiplatelet efficacy (clopidogrel resistance) in laboratory tests which might also be clinically relevant. Prasugrel is a new, orally active thienopyridine with an expected spectrum of biological activities similar to clopidogrel. Prasugrel, like clopidogrel, is also an inactive prodrug that has to be transformed into the active metabolite by the liver cytochrome P450 s... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1079348 Sat, 08 Dec 2007 01:34:59 +0100 1079348 http://www.medworm.com/index.php?rid=1079347&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18060246%26dopt%3DAbstract Authors: Spöhr F, Böttiger BW The prognosis of patients suffering cardiac arrest is still poor. Until today, no drug therapy has shown to improve longterm survival after cardiac arrest. Thrombolysis has been shown to be an effective therapy in patients with acute myocardial infarction (AMI) or massive pulmonary embolism (PE). Since 50-70% of cardiac arrests are caused by AMI or massive PE, the combination of cardiopulmonary resuscitation (CPR) and thrombolytic therapy appears to be sensible. As experimental studies have shown, thrombolytic therapy during CPR may not only be a causal treatment for coronary or pulmonary arterial obstruction by thrombi, but may also improve microcirculatory reperfusion after cardiac arrest. Although numerous small clinical studies have shown the... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1079347 Sat, 08 Dec 2007 01:34:59 +0100 1079347 http://www.medworm.com/index.php?rid=1079346&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18060247%26dopt%3DAbstract Authors: Schwarz M, Hagemeyer CE, Peter K, Bode C The development of monoclonal antibodies facilitated an enormous progress in modern medicine in the last years. The targeted inhibition of defined molecular structures allows therapeutic concepts, which before were inconceivable. There are numerous antibodies in clinical use within the area of tumour therapy, chronically inflammatory diseases, transplantation, infections and also in cardiovascular medicine. Different antibody formats are used such as IgG molecules, Fab fragments and single chain antibodies. Single chain antibodies represent the smallest functional form of the antibody and are used preferentially as recombinant antibodies. The therapeutic possibilities of antibody technology are extended by fusion to radioactive or thera... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1079346 Sat, 08 Dec 2007 01:34:59 +0100 1079346 http://www.medworm.com/index.php?rid=1079345&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18060248%26dopt%3DAbstract Authors: Bondke A, Buschmann IR, Bode C, Buschmann EE, A stimulation of collateral vessel growth is an attractive alternative therapeutic tool especially for patients with diffuse occlusive vessel disease. Extensive in vivo and in vitro studies in the preceeding decades have led us to a thorough understanding of basic arteriogenic principles. Due to the timeline of naturally occuring arteriogenesis, a well-timed therapeutic induction appears to be limiting for effective proarteriogenic therapies in high-risk patients. Potential therapeutic approaches are based on a stimulation of monocyte function through cytokine application. First clinical studies have, nevertheless, demonstrated the limits of a unifactorial therapy. Therefore, a stimulation of the mechanical inductor of arteriogeni... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1079345 Sat, 08 Dec 2007 01:34:59 +0100 1079345 http://www.medworm.com/index.php?rid=1079344&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18060249%26dopt%3DAbstract Authors: Preissner KT Upon vascular injury, locally controlled haemostasis prevents life threatening blood loss and ensures wound healing. Intracellular material derived from damaged cells at these sites will become exposed to cells and plasma proteins and could thereby influence vascular homeostasis, blood coagulation and defense mechanisms. Recently, this concept was documented by several studies indicating that extracellular nucleic acids, and RNA in particular, serve as promoter of blood coagulation in vivo and significantly increase the permeability across brain endothelial cells in vitro and in vivo. As procoagulant cofactor and "natural foreign material", RNA triggers the contactphase pathway of blood coagulation and thereby contributes to pathological thrombus formation. Admini... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1079344 Sat, 08 Dec 2007 01:34:59 +0100 1079344 http://www.medworm.com/index.php?rid=1079343&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18060250%26dopt%3DAbstract Authors: Becker RC, Oney S, Becker KC, Rusconi CP, Sullenger B The translation of fundamental science-based constructs to the preemptive identification and optimal management of individuals with or those at risk for thrombotic disorders of the cardiovascular system has taken a step closer to being realized with the development of molecular technologies that include nucleic acid aptamers and their complimentary oligonucleotide antidotes. Herein, we summarize our experience with factor IX and von Willebrand factor aptamers, and introduce the era of antithrombotic pharmacobiologic therapy. PMID: 18060250 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1079343 Sat, 08 Dec 2007 01:34:59 +0100 1079343 http://www.medworm.com/index.php?rid=1006686&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17939278%26dopt%3DAbstract Authors: Krauth MT, Pabinger I PMID: 17939278 [PubMed - indexed for MEDLINE] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=1006686 Tue, 06 Nov 2007 14:05:26 +0100 1006686 http://www.medworm.com/index.php?rid=981918&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17960351%26dopt%3DAbstract Authors: Peest D, Ganser A The multiple myeloma (MM) has an incidence of 3-4/100,000 in the Caucasian population. MM has to be distinguished from smouldering MM and monoclonal gammopathy of uncertain significance (MGUS). In younger patients (<65 years) a good long-term remission is the aim of therapy, while in the elderly patients with comorbidities the aim is a good partial remission with good quality of life. In the elderly this can be achieved with a combination of melphalan and prednisone. High-dose chemotherapy, often as a tandem transplantation, is part of standard therapy of MM patients <65 years. However, allogeneic stem cell transplantation is the only curative approach. New substances approved for treatment of relapsed MM include bortezomib, thalidomide, and lenalidomid... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=981918 Fri, 26 Oct 2007 04:00:00 +0100 981918 http://www.medworm.com/index.php?rid=957084&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17938760%26dopt%3DAbstract Hamostaseologie. 2007;27(4):237-238 Authors: Schambeck CM PMID: 17938760 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=957084 Wed, 17 Oct 2007 14:07:11 +0100 957084 http://www.medworm.com/index.php?rid=957083&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17938761%26dopt%3DAbstract Authors: Lewandrowski U, Zahedi RP, Moebius J, Sickmann A Platelets are anucleated cells and therefore ideal research objects for modern proteome analyses. Despite their importance in thrombosis and hemostasis the protein content of platelets is still poorly characterized in major parts. In preparation for bioinformatic and functional studies a series of proteomic analyses was conducted for platelet subproteomes as well as for posttranslational modifications. Thereby, the identification of 489 proteins, over 550 phosphorylations and 326 N-glycosylation sites was possible, which were not identified in previous proteome studies of platelets. Those results represent new research possibilities for functional characterization of platelet proteins as well as their modifications. PMID: 17... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=957083 Wed, 17 Oct 2007 14:07:11 +0100 957083 http://www.medworm.com/index.php?rid=957082&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17938762%26dopt%3DAbstract Authors: Reininger AJ Haemostasis is the concerted action of blood components aimed at prevention of blood loss after vessel injury. Thrombosis is the other side of the coin, a misled physiological process, i.e. a haemostatic reaction occurring at a diseased vessel wall. Haemodynamic forces enrich platelets in a fluid boundary layer adjacent to the vessel wall where they flow along the endothelium scanning it for defects. Once the platelets detect an injury they immediately adhere - a process beginning with initial deceleration and attachment via glykoprotein (GP) Ibalpha receptor-binding to immobilized von Willebrand factor (VWF). The GPIb receptor requires no stimulation. This is in contrast to subsequently interacting receptors such as integrin alphaIIbbeta3 (GPIIb/IIIa), integrin a... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=957082 Wed, 17 Oct 2007 14:07:11 +0100 957082 http://www.medworm.com/index.php?rid=957081&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17938763%26dopt%3DAbstract Authors: Zotz RB, Scharf RE Apart from on-label indications, recombinant factor VIIa (rFVIIa) is increasingly administered for treatment of life threatening bleeding events when appropriate standard therapy fails. Case reports and short treatment series document the efficacy and safety of rFVIIa to achieve haemostasis in patients with platelet function disorders and thrombocytopenias of various origin. An established on-label indication for the use of rFVIIa is given in patients with Glanzmann thrombasthenia with refractoriness to transfusions of platelet concentrates. Bolus applications of rFVIIa at dosages between 80 and 120 microg/kg body weight every 1.5 to 3 h are also administered successfully in patients with Bernard-Soulier syndrome, platelet storage pool defects, and other acq... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=957081 Wed, 17 Oct 2007 14:07:11 +0100 957081 http://www.medworm.com/index.php?rid=957080&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17938764%26dopt%3DAbstract Authors: Isermann B, Nawroth PP The availability of mice with defined defects within the hemostatic system enabled researchers to identify a role the coagulation system for embryonic and placental development. However, the role of platelets during development has only recently been experimentally addressed, giving some insight into potential functions of platelets during development. Thus, a quantitative embryonic platelet defect (severe thrombopenia secondary to NF-E2 deficiency) is associated with an embryonic growth retardation and reduced vascularisation of the placenta. Maternal platelet deficiency is associated with placental haemorrhage, which, however, does not impair embryonic or maternal survival. In vitro studies established that platelets or platelet conditioned medium regu... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=957080 Wed, 17 Oct 2007 14:07:11 +0100 957080 http://www.medworm.com/index.php?rid=957079&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17938765%26dopt%3DAbstract Authors: Schambeck CM Bleeding tendency as a result of clotting factor deficiency is common knowledge. The counterpart, i.e. thrombophilia due to high clotting factor levels, is not surprising, but an association between factor level and thrombosis risk has just recently been described. The role of high factor VIII (FVIII) levels is well documented. The risk of high FVIII levels for the first event is similarly high as that of APC resistance. There is a familiar background of high FVIII levels. Alterations within the FVIII or the von Willebrand factor genes seem to be not causal since polymorphisms of these genes are not associated with venous thromboembolism. An increased FVIII/VWF ratio indicates a reduced FVIII clearance. Probably, the low-density lipoprotein receptor-related protei... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=957079 Wed, 17 Oct 2007 14:07:11 +0100 957079 http://www.medworm.com/index.php?rid=957078&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17938766%26dopt%3DAbstract Authors: Gieseler F, Stelck B, Blume LF, Denker M, Dohrmann P, Mundhenke C, Bauerschlag D, Tiemann M, Kunze T Malignant effusions are a frequent problem for cancer patients. Due to the high resistance of tumor cells within these effusions, no effective treatment has been defined yet. Most patients exhibit additional phenomena related to hyper-coagulability such as elevated levels for d-dimers and prothrombin fragments f1.2; half of them suffer from manifest thrombosis or complications. We followed the hypothesis that the activated coagulation system contributes to the resistance of tumor cells and analyzed the effusions from cancer patients. The majority of isolated tumor cells aberrantly expressed PAR-1 thrombin receptors. In vitro pre-incubation of PAR-1 expressing human leukemia cel... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=957078 Wed, 17 Oct 2007 14:07:11 +0100 957078 http://www.medworm.com/index.php?rid=957077&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17938767%26dopt%3DAbstract Authors: Dempfle CE The primary focus of the blood coagulation system is the prevention of blood loss. The system is regulated by various inhibitors, and by the fibrinolytic system, which removes the final product of the blood coagulation system, the fibrin clot. The fibrinolytic system is activated in the course of coagulation activation. The thrombin-activated fibrinolysis inhibitor (TAFI) is an important regulator of fibrinolysis. TAFI is activated by thrombin, and activation is enhanced in the presence of thrombomodulin. TAFIa, the product of TAFI activation, removes lysine residues from fibrin, which are essential for the binding of t-PA, plasminogen, and plasmin to fibrin. The fibrin loses its cofactor activity in t-PA-induced plasminogen activation, resulting in less plasmin, an... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=957077 Wed, 17 Oct 2007 14:07:11 +0100 957077 http://www.medworm.com/index.php?rid=957076&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17938768%26dopt%3DAbstract Authors: Perzborn E, Kubitza D, Misselwitz F Rivaroxaban (Xarelto((R))) is a novel, oral, direct Factor Xa (FXa) inhibitor in late-stage development for the prevention and treatment of thromboembolic disorders. Rivaroxaban inhibits clot-associated and free FXa activity, and prothrombinase activity, and reduces thrombin generation. In animal models, rivaroxaban prevented venous and arterial thrombosis, and was effective at treating venous thrombosis. Rivaroxaban has high oral bioavailability, a rapid onset of action and predictable pharmacokinetics. In phase II studies, rivaroxaban was effective and well tolerated for the prevention of venous thromboembolism (VTE) after major orthopaedic surgery, and for the treatment of deep vein thrombosis. In a phase III study, rivaroxaban demonstrat... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=957076 Wed, 17 Oct 2007 14:07:11 +0100 957076 http://www.medworm.com/index.php?rid=957075&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17938769%26dopt%3DAbstract We report on an 18 year old patient with severe haemophilia A who had developed a high-titre factor VIII inhibitor in the age of five years. ITT required the implantation of a port system. The postoperative course was complicated by severe septicaemia with congestive cardiac failure. The port catheter was removed due to recurrent fever after 26 days. Our patient developed dilative cardiomyopathy. ITT had to be stopped and was replaced by on demand therapy with an activated prothrombin complex concentrate. Cardiomyopathy resulted in congestive heart failure, severe ventricular arrhythmias and the death of the young man. In patients with haemophilia, dilative cardiomyopathy and development of inhibitors the possibility of cardiac transplantation should be evaluated before increasing inhibito... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=957075 Wed, 17 Oct 2007 14:07:11 +0100 957075 http://www.medworm.com/index.php?rid=808182&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17694221%26dopt%3DAbstract Hamostaseologie. 2007;27(3):153 Authors: Ziemer S PMID: 17694221 [PubMed - as supplied by publisher] (Source: Hamostaseologie) Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=808182 Mon, 20 Aug 2007 00:49:22 +0100 808182 http://www.medworm.com/index.php?rid=808181&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17694222%26dopt%3DAbstract In this study two aspirin sensitive platelet function tests which are based on the analysis of whole blood were evaluated and correlated with each other. In vitro bleeding time was determined using the PFA-100 analyzer (Dade Behring, Marburg, Germany) using the collagen/epinephrine cartridge and citrated blood. Whole blood aggregometry was performed using the Multiplate analyzer (Dynabyte medical, Munich, Germany) using hirudin blood (25 mug/ml). Aggregatin was triggered using arachidonic acid (ASPItest), collagen (COLtest) or TRAP-6 (thrombin receptor activating peptide, TRAPtest). Following informed consent citrated blood and hirudin blood was drawn from 76 cardiovascular patients which were on long-term aspirin therapy (aspirin patients). In addition hirudin blood was drawn from 57 heal... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=808181 Mon, 20 Aug 2007 00:49:22 +0100 808181 http://www.medworm.com/index.php?rid=808180&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17694223%26dopt%3DAbstract We examined if aggregometry can be used to see the effect of antiplatelet drugs (ASA 30, 50, 100, 300 mg/d, clopidogrel 75 mg/d or ASA 100 + clopidogrel 75 mg/d). A modified platelet aggregation test was used to investigate maximum aggregation in response to ADP, collagen, adrenalin and arachidonic acid. Reference values were established based on healthy individuals. We devised a simple scoring system for detection of inadequate platelet inhibition. Compared with the control group, we detected a significant delay of maximum aggregation in response to all agonists in patients on ASA and combination therapy ASA + clopidogrel. Patients on clopidogrel alone were found to have prolonged aggregation when induced with ADP, collagen and arachidonic acid. The failure rate to achieve adequate platel... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=808180 Mon, 20 Aug 2007 00:49:22 +0100 808180 http://www.medworm.com/index.php?rid=808179&cid=s_33573_19_f&fid=33573&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17694224%26dopt%3DAbstract Authors: Koscielny J, Ziemer S, Radtke H, Schmutzler M, Kiesewetter H, Salama A, von Tempelhoff GF The findings of a large prospective study designed to identify primary and/or secondary haemostatic disorders before surgical interventions are presented. A total of 5649 unselected adult patients were enrolled to identify impaired haemostasis before surgical interventions. Each patient was asked to answer a standardized questionnaire concerning bleeding history. Activated partial thromboplastin time (aPTT), prothrombin time (PT), and platelet counts (PC) including PFA-100 (platelet function analyzer): collagen-epinephrine (C/E), and collagen-ADP (C/ADP) were routinely done in all patients. Additional tests, bleeding time (BT), von Willebrand factor (VWF : Ag, VWF : Rcof) and a further ha... Hamostaseologie journals http://www.medworm.com/rss/comments.php?id=808179 Mon, 20 Aug 2007 00:49:22 +0100 808179