MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Head and Neck Pathology' source. Thu, 09 Feb 2012 00:42:12 +0100 http://www.medworm.com/index.php?rid=5661206&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb7812531203v3471%2F Abstract  A 16-year-old previously asymptomatic boy presented with complaints of fatigue, weight loss, and back pain for several months. Imaging studies revealed a large superior mediastinal mass, numerous bilateral pulmonary nodules, and multiple lytic bone lesions. A needle biopsy from a sternal lesion showed a poorly differentiated carcinoma, immunoreactive for cytokeratins and EMA and immunonegative for various organ/tissue-specific markers. His past medical history was significant for excision of a parotid gland tumor 5 years earlier. Histologic review of the salivary gland tumor revealed a pleomorphic adenoma containing a microscopic focus of invasive carcinoma (carcinoma ex pleomorphic adenoma). By immunohistochemistry, both the salivary gland tumor and the diss... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5661206 Wed, 01 Feb 2012 17:13:46 +0100 5661206 http://www.medworm.com/index.php?rid=5639888&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fal660w71275u6368%2F Abstract  Osteomas of the cranial sinuses are rare, benign bony tumors that can be complicated by the formation of an intracranial pneumatocele. If not treated promptly, a pneumatocele can lead to abscess formation, meningitis, or ventriculitis. In the present case, an intracerebral pneumatocele was formed when an 18 cm3 osteoma breached the posterior wall of the frontal sinus creating a one-way valve through which air could enter the intracranial cavity. The patient presented after forceful sneezing with nonspecific symptoms of headache, nausea, and vomiting. CT demonstrated a frontal collection of loculated air with mass effect within the left cerebral hemisphere. A partly mineralized mass occupied the left superior nasal ethmoid sinus and left frontal sinus. Of inter... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5639888 Tue, 24 Jan 2012 18:14:59 +0100 5639888 http://www.medworm.com/index.php?rid=5639889&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj773w24288687141%2F We present the case of a 63-year-old woman diagnosed with an intercalated duct lesion of the parotid. Her case is illustrative of the difficulty and importance of an accurate pathologic diagnosis in the management of patients with these lesions. Content Type Journal ArticleCategory Case ReportPages 1-4DOI 10.1007/s12105-012-0329-8Authors Matthew R. Naunheim, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA, USAHarrison W. Lin, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA, USAWilliam C. Faquin, Department of Pathology, Massachusetts General Hospital, Boston, MA, USADerrick T. Lin, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA Journal Head and Neck PathologyOnline ISSN 1936-0568... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5639889 Tue, 24 Jan 2012 07:15:35 +0100 5639889 http://www.medworm.com/index.php?rid=5585687&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh183223223rh1725%2F In this study, three additional cases of ALT/WDLS located on the tongue (2 cases) and the lower lip (1 case), respectively, are described. Analysis of the salient clinicopathologic features of 63 oral ALT/WDLS cases previously reported in the English language literature, as well as of the 3 cases presented in this study, indicates that the indolent biologic behavior of this tumor justifies its designation as a locally spreading malignant neoplasm, affording a rather conservative surgical approach. Content Type Journal ArticleCategory Case ReportPages 1-10DOI 10.1007/s12105-011-0327-2Authors Evangelia Piperi, Department of Oral Pathology and Medicine, Dental School, University of Athens, 2 Thivon Street, 11527 Athens, GreeceKonstantinos I. Tosios, Department of Oral Pathology and... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5585687 Tue, 10 Jan 2012 17:02:08 +0100 5585687 http://www.medworm.com/index.php?rid=5573444&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa85k0t387m444844%2F This study supports our previous findings associating cytoplasmic ezrin with more aggressive behavior and poorer outcome and indicates the need for a multi-institutional study to validate the use of cytoplasmic ezrin as a biomarker for treatment planning in head and neck squamous cell carcinoma. Content Type Journal ArticleCategory Original PaperPages 1-12DOI 10.1007/s12105-011-0328-1Authors Nicolas F. Schlecht, Department of Epidemiology and Population Health, Albert Einstein College of Medicine and Montefiore Medical Center, 1300 Morris Park Avenue, Bronx, NY 10461, USAMargaret Brandwein-Gensler, Department of Pathology, University of Alabama Birmingham, Birmingham, AL 35249, USARichard V. Smith, Department of Otorhinolaryngology, Head and Neck Surgery, Albert Einstein College o... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5573444 Fri, 06 Jan 2012 16:47:34 +0100 5573444 http://www.medworm.com/index.php?rid=5573445&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F12p326x7356k4783%2F Abstract  Salivary gland tumors (SGTs) of epithelial origin are relatively rare, and worldwide reports show considerable variations in their epidemiology. The aim of this study was to examine, for the first time, the records of SGTs from two very distant geographical locations, Finland (two medical centers) and Israel (one medical center) between 1999 and 2008, based exclusively on the 2005 WHO classification of head and neck tumors, and to compare those data to the other available (single-center) studies that used the same classification. A total of 2,218 benign and malignant tumors diagnosed in the three centers were analyzed. Differences in classification of the tumors were found between the two geographical locations as well as between the two centers from Finland. Ther... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5573445 Fri, 06 Jan 2012 16:47:33 +0100 5573445 http://www.medworm.com/index.php?rid=5562679&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F217g575885161w23%2F Abstract  Imatinib mesylate (STI-571, Gleevec®), a tyrosine kinase inhibitor, is a first-line medication for treating chronic myeloid leukemia (CML). Clinical studies revealed very good hematological responses without significant side effects. However, imatinib may lead to mucosal pigmentation. Three patients, two males aged 64 and 53 and one female aged 29 presented with a painless, diffuse, grey-blue pigmentation of the mucosa of the hard palate. Both male patients had a history of CML and had been on imatinib for 4 and 10 years, respectively. The female patient had been on imatinib for 4 years for pelvic fibromatosis. Histopathologically, deposition of fine, dark-brown, spherical granules was noted within the connective tissue. There was no inflammation or hemo... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5562679 Fri, 30 Dec 2011 16:49:59 +0100 5562679 http://www.medworm.com/index.php?rid=5562680&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl4r68k66g29p63r2%2F Abstract  Metastatic tumors to the oral cavity are uncommon and a thyroid origin is considered exceedingly rare. A case of metastatic papillary thyroid carcinoma (PTC) presenting as a painful swelling in the right posterior maxilla of a 63-year-old male is reported here. The patient had been diagnosed with PTC 2 years ago and treated with thyroidectomy and radioactive iodine treatment. Radiographically, the metastatic lesion presented as a poorly-defined radiolucent lesion around an impacted maxillary third molar in the right maxilla. Histopathologic examination revealed features of PTC which was immunohistochemically positive for pancytokeratin, keratin 19 and thyroglobulin. Imaging studies revealed the presence of residual maxillary and neck disease as well as additi... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5562680 Fri, 30 Dec 2011 07:09:11 +0100 5562680 http://www.medworm.com/index.php?rid=5553748&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa3wn63381876155j%2F Abstract  Human papillomavirus (HPV)—related oropharyngeal squamous cell carcinoma (SCC) is associated with favorable patient survival. Tumor HPV status at primary diagnosis is critical for proper management, and p16 immunohistochemistry (IHC) has emerged as a reliable, single, surrogate marker. It is not known, however, if small biopsy specimens are completely adequate for p16 evaluation. From a database of oropharyngeal SCC for which p16 IHC and histologic typing were already performed, all patients (32) who had available in-house primary tumor biopsy specimens and also subsequent surgical resections were analyzed. p16 IHC was performed along with histologic typing into: Type 1 keratinizing SCC, Type 2 nonkeratinizing SCC with maturation, and Type 3 nonkeratinizing SCC.... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5553748 Tue, 27 Dec 2011 16:49:47 +0100 5553748 http://www.medworm.com/index.php?rid=5546086&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm234746856344735%2F We present an unusual case of LCH of the thyroid gland, with variable diagnoses on fine needle aspiration (FNA) cytology, and literature review of all English reported cases. Content Type Journal ArticleCategory Case ReportPages 1-11DOI 10.1007/s12105-011-0321-8Authors Darren K. Patten, Department of Biosurgery and Surgical Oncology, St Mary’s Hospital, Imperial College Healthcare NHS Trust, London, W2 1NY UKZubair Wani, Department of Accident and Emergency Medicine, The Horton General Hospital, Oxford, UKNeil Tolley, Department of Endocrine Surgery, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, UK Journal Head and Neck PathologyOnline ISSN 1936-0568Print ISSN 1936-055X (Source: Head and Neck Pathology) Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5546086 Fri, 23 Dec 2011 16:53:41 +0100 5546086 http://www.medworm.com/index.php?rid=5546087&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw657585841786617%2F Abstract  A pathologically elongated coronoid process forming a joint with the zygomatic arch and bone is termed as “Jacob’s disease.” Herein, we present a case of Jacob’s disease, which has rarely been reported in the literature. Moreover, very few cases have been reported from the Indian subcontinent. A 28 years-old male reported to us with progressive restriction of mouth opening. After detailed imaging, coronoidectomy was performed through an intraoral approach. A mushroom-shaped gross specimen was obtained. Osteochondroma of the coronoid process was diagnosed based on the histopathologic examination of the excised tissue. Although Jacob’s disease is seldom considered in the list of differential diagnoses for restricted mouth opening, our case highlights ... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5546087 Wed, 21 Dec 2011 20:07:58 +0100 5546087 http://www.medworm.com/index.php?rid=5527643&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F24j187800w743822%2F Abstract  Primary sinonasal tract mucoepidermoid carcinomas (MEC) are uncommon tumors that are frequently misclassified, resulting in inappropriate clinical management. The design of this study is retrospective. Nineteen cases of MEC included 10 females and 9 males, aged 15–75 years (mean, 52.7 years); males, on average were younger by a decade than females (47.2 vs. 57.7 years). Patients presented most frequently with a mass, obstructive symptoms, pain, and/or epistaxis present for a mean of 12.6 months. The majority of tumors involved the nasal cavity alone (n = 10), maxillary sinus alone (n = 6), or a combination of the nasal cavity and paranasal sinuses (n = 3) with a mean size of 2.4 cm. Most patients presented at a lo... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5527643 Mon, 19 Dec 2011 16:50:02 +0100 5527643 http://www.medworm.com/index.php?rid=5527644&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh8v686003401w172%2F Abstract  External auditory canal (EAC) osteomas are rare, benign bony neoplasms that occur in wide range of patients. While chronic irritation and inflammation have been suggested as causal factors in several cases, significant data is lacking to support these suspicions. Symptoms are rare and can include hearing loss, vertigo, pain and tinnitus. Diagnosis is made based on a combination of clinical history and examination, radiographic imaging, and histopathology. Osteomas of the EAC are usually found incidentally and are unilateral and solitary. Computed tomography reveals a hyperdense, pedunculated mass arising from the tympanosquamous suture and lateral of the isthmus. Histopathologically, EAC osteomas are covered with periosteum and squamous epithelium, and consist of ... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5527644 Mon, 19 Dec 2011 16:50:00 +0100 5527644 http://www.medworm.com/index.php?rid=5527645&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F82nt8158h5678211%2F Abstract  A 25-year-old female presented with a well-defined, painless mass of 1 year’s duration in the right parotid gland. MR imaging revealed a relatively well-circumscribed lesion involving the deep and superficial lobes of the right parotid gland. Histologic examination of the resection resulted in a diagnosis of sclerosing polycystic adenosis, a rare benign salivary gland entity of presumed non-neoplastic origin. The clinical, radiographic, and morphologic features of sclerosing polycystic adenosis are discussed. Content Type Journal ArticleCategory Sine qua non Radiology-PathologyPages 1-3DOI 10.1007/s12105-011-0317-4Authors Colin A. Eliot, Naval Postgraduate Dental School, Bethesda, MD, USAAlice B. Smith, Uniformed Service University of the Health Scienc... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5527645 Mon, 19 Dec 2011 16:49:58 +0100 5527645 http://www.medworm.com/index.php?rid=5507283&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F025421165061hn55%2F Abstract  Abnormalities in cell cycle regulation, tumor suppressor gene functions and apoptosis are frequent events in tumorigenesis. Their role in the pathogenesis and prognosis of primary mucosal melanomas (MM) of the upper aerodigestive tract remains unknown. Sixty-four patients (40 men, 24 women, median age 64 years) with MM were included in this study; 32 had tumors in the nasal/paranasal cavities, 28 in the oral cavity and 4 in the pharynx. Archival tissues from 47 initial mucosal tumors, 17 mucosal recurrences, and 13 nodal/distant metastases were subjected to immunohistochemistry using antibodies against p16, p53, and bcl-2. The results were correlated with histological features and survival data. Expressions of p16, p53, and bcl-2 proteins were seen in 25% (N&... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5507283 Mon, 12 Dec 2011 17:16:55 +0100 5507283 http://www.medworm.com/index.php?rid=5507284&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7p474r63658870u4%2F Abstract  To evaluate disease dynamics, treatment results, and frequency of malignant transformation. Ten-year single center retrospective study. The study included 171 patients, 28–99 years old. Follow-up was 1–16 years. 49.5% exhibited changes in clinical presentation, with 19% yearly increase of probability for type shift. Index of extent (number of oral locations) showed a mean 40% decrease and 94.1% reported improvement. There were significant differences between treated and untreated patients (P = 0.012). Patients with or without systemic diseases had identical treatment requirements for oral lesions. The prevalence of SCC was 5.8%. Oral lichen planus constantly changes presentation and extent of involvement. The effect of systemic diseases was ... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5507284 Mon, 12 Dec 2011 17:16:54 +0100 5507284 http://www.medworm.com/index.php?rid=5478723&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg556107m73963314%2F Abstract  Segmental Odontomaxillary Dysplasia (SOD) is an uncommon developmental disorder of unknown etiology that causes a unilateral alteration of the maxilla associated with an abnormal growth and maturation of bone, lack of one or both premolars and delayed tooth eruption on the affected side, alteration of adjacent gingival tissue with or without facial cutaneous lesions. Radiographically is observed an irregular trabecular pattern and reduction of the maxillary sinus. There are 50 cases reported in the English-language literature. A literature review is herein presented emphasizing the clinical, radiographic, and histological features, and three additional cases of SOD affecting a 22 years-old woman, a 18 years-old man, and a 5 years-old boy, respectivel... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5478723 Fri, 02 Dec 2011 17:28:07 +0100 5478723 http://www.medworm.com/index.php?rid=5470569&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd0t118332272912q%2F We report a case found in a 79-year-old female 8 months after functional endoscopic sinus surgery during which sinus cavities had been packed with gauze coated with Terra-Cortril (a paraffin-based tetracycline/steroid ointment). The preoperative diagnosis was suggested during CT of the paranasal sinuses by the presence of macroscopic paraffin retention cysts having a characteristic fat density. To our knowledge, our case represents the first report of sinonasal myospherulosis suggested by CT. Content Type Journal ArticleCategory Case ReportPages 1-5DOI 10.1007/s12105-011-0310-yAuthors Bruno Coulier, Department of Medical Imaging, Clinique St Luc, 5004 Bouge, Namur, BelgiumOlivier Desgain, Department of Otorhinolaryngology, Clinique St Luc, 5004 Bouge, Namur, BelgiumIsabelle... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5470569 Wed, 30 Nov 2011 04:38:26 +0100 5470569 http://www.medworm.com/index.php?rid=5470568&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw1771753885w6472%2F Abstract  Mammary analogue secretory carcinoma (MASC) was recently identified as a distinct salivary gland neoplasm, morphologically resembling intercalated duct cell predominant acinic cell carcinoma (AciCC). To determine how frequently MASC has mimicked an intercalated duct cell predominant AciCC, we reviewed AciCC diagnosed from 1956 to 1975. Nine AciCC consecutively diagnosed in that period were identified. Based on morphologic examination, one case diagnosed as AciCC in a male patient in 1960 was re-classified as MASC [confirmed by fluorescence in situ hybridization (FISH) showing ETV6 translocation]. Another case diagnosed as AciCC of the palate in a female patient in 1975 was re-classified as mucoepidermoid carcinoma (based on the lack of acinar differentiation, prese... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5470568 Wed, 30 Nov 2011 04:38:26 +0100 5470568 http://www.medworm.com/index.php?rid=5443562&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F02r763p7lr873j33%2F This report, for the first time, describes the mucosal ulceration related to intravenous use of zoledronic acid (ZA). A 52-year-old female patient presented with painful ulcers on both cutaneous/mucosal surfaces of the lower lip and a 2-month history of osteonecrosis of the mandible beside the right lower canine. Her medical record included intravenous administration of ZA for 10 months for primary breast cancer metastatic to bone. Examination of the peripheral blood showed severe anemia and a slightly increased white blood cell count, due to urinary tract infection by E. coli, but no evidence of a viral infection. The treatment of anemia and E. coli infection did not improve the labial ulcers. Biopsy from the mucosal lesion revealed a non-specific ulceration with moderate infla... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5443562 Mon, 21 Nov 2011 18:08:27 +0100 5443562 http://www.medworm.com/index.php?rid=5433477&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fcun1p4j2421g1548%2F Abstract  Malignant salivary gland tumors (MST) represent over more than 24 distinct morphological subtypes. Most high grade tumors arise from the excretory duct portion of the salivary gland apparatus; the remainder from the intercalated duct portion. Altered p27/skp-2 expression has been associated with tumor aggressiveness and histologic differentiation. In our study, we analyzed p27/skp-2 expression proteins on series of malignant salivary gland tumors in order to assess their value as a histogenetic marker, which is relevant to tumor grade. 61 MST cases were segregated by proposed histogenesis and immunohistochemistry was performed using antibodies directed against p27 and skp-2. MST of proposed intercalated duct origin (n = 27) showed strong p27 expression (n... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5433477 Fri, 18 Nov 2011 06:55:18 +0100 5433477 http://www.medworm.com/index.php?rid=5433478&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu4qqg23t301n0411%2F We present a rare case of BPOP involving the mandible in a 10 year old African American male. Microscopically, a fibro-cartilaginous cap giving rise to a proliferation of variably mineralized osteophytic finger-like projections of bone was seen. Multiple trabeculae of “blue bone” were noted as well as numerous atypical appearing chondrocytes. The lesion recurred within 4 months following the initial excision but has not recurred to date after the second local excision. To the best of our knowledge, this is the first report of BPOP arising in the mandible. In addition, we discuss the clinical and microscopic features, differential diagnosis, and prognosis of this rare entity. We present a case of BPOP of the mandible and believe this is the first report of such a case i... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5433478 Fri, 18 Nov 2011 06:55:17 +0100 5433478 http://www.medworm.com/index.php?rid=5411593&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh73h462w761uk566%2F Abstract  Altered cadherin expression is important for metastasis in many carcinomas including head and neck squamous cell carcinoma (SCC). We evaluated E- and N-cadherin expression specifically in oropharyngeal SCC and correlated this with clinical and pathologic features. Oropharyngeal SCC patients with clinical follow up information were identified from clinician databases from 1996 through 2007 and tissue microarrays created. Tumors had been previously typed histopathologically as keratinizing, non-keratinizing, or non-keratinizing with maturation, and had known p16 and human papillomavirus status, respectively. Immunohistochemistry was performed on the microarrays, and staining was evaluated for presence and intensity (0 = negative, 1 = weak, 2 ... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5411593 Wed, 09 Nov 2011 17:58:34 +0100 5411593 http://www.medworm.com/index.php?rid=5391007&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl1351520m6k70v57%2F We present a case (55-year-old) with a metastasis to the sphenoid sinus from an occult prostatic adenocarcinoma as the first evidence of disease. The patient’s symptoms were progressive left-sided headache of a few months duration and a 2-week history of blurred vision with diplopia. Clinical examination revealed a left cranial nerve III palsy and ptosis. A computed tomography scan showed a 2 cm large, well delineated soft tissue lesion involving the left sphenoid sinus and extending to the left cavernous sinus with sclerosis of the adjacent sphenoid bone. Histological and immunohistochemical examinations revealed a poorly differentiated adenocarcinoma that was positive for prostate specific antigen (PSA) and broad-spectrum cytokeratins (Cam 5.2). Subsequent urological examina... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5391007 Fri, 04 Nov 2011 05:44:45 +0100 5391007 http://www.medworm.com/index.php?rid=5391006&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F520560u777760318%2F Abstract  Laryngeal papillomas are benign tumors that frequently recur and can compromise airways. We investigated HPV genotype, physical status, and protein expression in juveniles versus adults. Thirty-five laryngeal papilloma specimens were obtained from ten juveniles (1–16 years) and eleven adults (24–67 years). In cases of recurrent papillomatosis (7 juveniles, 7 adults), the first and last papillomas were assayed. HPV type was determined by GP5+/6+ PCR and dot blot hybridization. In situ hybridization (ISH) was performed on 34 specimens; the data were recorded in terms of diffuse (episomal HPV) and punctate (integrated HPV) signal patterns. Immunohistochemistry for the HPV L1 capsid protein, a marker of HPV productive status, was performed on 32 samples.... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5391006 Fri, 04 Nov 2011 05:44:45 +0100 5391006 http://www.medworm.com/index.php?rid=5325928&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff627074jw676l580%2F Abstract  Solitary fibrous tumors (SFTs) are rare tumors in the head and neck, and even more so in the parotid gland. The mass-like clinical presentation and histologic features result in frequent misclassification, resulting in inappropriate clinical management. There are only a few reported cases in the English literature. Twenty-one patients with parotid gland solitary fibrous tumor were compiled from the English literature (Medline 1960–2011) and integrated with this case report. The patients included 11 males and 11 females, aged 11–79 years (mean, 51.2 years), who presented with a parotid gland painless mass gradually increasing in size or with compression symptoms, with a mean duration of symptoms of 24.7 months. The mean tumor size was 4.5 cm.... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5325928 Sat, 15 Oct 2011 15:47:59 +0100 5325928 http://www.medworm.com/index.php?rid=5317329&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F54257522tg77j871%2F Abstract  Xeroderma pigmentosum (XP) is a rare autosomal recessive defect in DNA endonuclease activity that is associated with the development of cutaneous malignancies, at sun exposed sites, including basal cell carcinoma, squamous cell carcinoma, and melanoma. Squamous cell carcinomas are also known to target the anterior tongue. Patients sometimes develop angiosarcomas, and these invariably arise from sun-exposed skin. A biopsy was taken from a large mass arising in the anterior tongue of an 11-year-old girl with XP and a history of cutaneous basal cell carcinomas. The histopathologic findings demonstrated a high grade epithelioid neoplasm resembling a poorly differentiated squamous cell carcinoma, but the immunohistochemical profile (AE1/AE3 negative, p63 negative, CD31... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5317329 Mon, 10 Oct 2011 15:05:15 +0100 5317329 http://www.medworm.com/index.php?rid=5306564&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1620266x32h8l608%2F Abstract   Content Type Journal ArticleCategory Original PaperPages 1-5DOI 10.1007/s12105-011-0304-9Authors Shokoufeh Shahrabi Farahani, Harvard School of Dental Medicine, 49 Worthington Street #7, Boston, MA 02120, USAJohn Sexton, Wellesley, MA, USAJeffrey D. Stone, Lowell, MA, USAKevin Quinn, N. Dartmouth, MA, USASook-Bin Woo, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA Journal Head and Neck PathologyOnline ISSN 1936-0568Print ISSN 1936-055X (Source: Head and Neck Pathology) Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5306564 Fri, 07 Oct 2011 15:58:23 +0100 5306564 http://www.medworm.com/index.php?rid=5263425&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4p5542021j83341n%2F In this study, we have analyzed by immunohistochemistry the expression of VEGF, Ang-1, Ang-2 and the Angs receptor Tie2 in both the stroma and tumor cells of mucoepidermoid carcinoma (MEC) of salivary gland. We have demonstrated that when myofibroblasts were detected adjacent to the cancer cells, they were frequently associated with intense positive staining for Ang-1 and Ang-2, and no reactivity to VEGF and Tie2. These myofibroblast-rich Ang-1 and Ang-2-stained areas were more commonly found in high-grade MEC cases than in low-grade ones. As for the malignant cells, they frequently expressed all proteins studied, but Ang-2 and VEGF were detected at higher levels compared to Ang-1 and Tie2. Our results indicate that the MEC environment favors cooperative activity between Angs and VEG... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5263425 Sat, 24 Sep 2011 15:47:01 +0100 5263425 http://www.medworm.com/index.php?rid=5263426&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fkm2380j3512x415x%2F We present an additional case of lingual intestinal-type adenocarcinoma with mucinous features that occurred in association with cervical node metastasis and discuss the clinicopathologic features and histogenetic aspects of this rare entity. Content Type Journal ArticleCategory Case ReportPages 1-5DOI 10.1007/s12105-011-0301-zAuthors Denisa Slova, Department of Pathology and Laboratory Medicine, St. Luke’s-Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, St. Luke’s Division, Clark 4, 1111 Tenth Avenue, New York, NY 10025, USAAlberto Paniz Mondolfi, Department of Pathology and Laboratory Medicine, St. Luke’s-Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, St. Luke’s Division, Clark 4, 1111 Tenth Avenue, N... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5263426 Sat, 24 Sep 2011 15:47:00 +0100 5263426 http://www.medworm.com/index.php?rid=5228698&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6685v5081nn252j1%2F Abstract  Ganglioneuroblastic transformation in olfactory neuroblastoma (ONB) is an exceptionally rare phenomenon. We document the case of a patient with a poorly differentiated sinonasal malignancy that recurred following treatment with chemoradiotherapy and showed ganglioneuroblastic transformation. Although the index tumour showed neuroendocrine differentiation, it did not have the typical clinico-pathological features associated with ONB. We highlight the diagnostic difficulties in establishing an accurate diagnosis for undifferentiated sinonasal tumours and present evidence that the index tumour was an ONB. The current report is only the third case of ONB showing complete ganglioneuroblastic transformation. Content Type Journal ArticleCategory Case ReportPages 1-6D... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5228698 Wed, 14 Sep 2011 05:51:06 +0100 5228698 http://www.medworm.com/index.php?rid=5228697&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx1w0107p453071u5%2F Abstract  The glandular odontogenic cyst (GOC) is now a relatively well-known entity with recent reviews indicating over 100 cases reported in the English literature. The GOC’s importance relates to the fact that it exhibits a propensity for recurrence similar to the odontogenic keratocyst, and that it may be confused microscopically with central mucoepidermoid carcinoma (CMEC). Numerous histopathologic features for the GOC have been described, but the exact microscopic criteria necessary for diagnosis have not been universally accepted. Furthermore, some of the microscopic features of GOC may also be found in dentigerous, botryoid, radicular, and surgical ciliated cysts. The purpose of this multicenter retrospective study is to further define the clinical, radiographic, ... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5228697 Wed, 14 Sep 2011 05:51:06 +0100 5228697 http://www.medworm.com/index.php?rid=5228699&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F517jh80w64577858%2F Abstract  An important inconsistency currently exists in the literature on oral cancer. Reviewing this literature, one finds that the term oral cancer is defined and described with great variation. In a search in PubMed, at least 17 different terms were found for titles of papers reporting data on oral cancer. The variability of the terms used for designating anatomic regions and type of malignant neoplasms for reporting oral cancer has hampered the ability of researchers to effectively retrieve information concerning oral cancer. Therefore, it is sometimes extremely difficult to provide meaningful comparisons among various studies of oral cancer. Recently, a new ontological strategy that is rooted in consensus-based controlled vocabularies has been proposed to improve the ... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5228699 Wed, 14 Sep 2011 05:51:05 +0100 5228699 http://www.medworm.com/index.php?rid=5212530&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F53361v01651r0736%2F Abstract  A classic case of central giant cell lesion (CGCL) is presented with emphasis on clinical, radiologic, and histologic features. The differential is discussed including peripheral giant cell granuloma, brown tumor of hyperparathyroidism, and giant cell tumor of bone. The molecular pathway of osteoclastogenesis is selectively reviewed and applied to suggest possible etiologies of the giant cell lesions. CGCL syndromes and treatment are also discussed. Content Type Journal ArticleCategory Sine qua none Radiology-PathologyPages 1-4DOI 10.1007/s12105-011-0297-4Authors James C. Valentine, Department of Anatomic Pathology, Naval Medical Center San Diego, 34800 Bob Wilson Drive, San Diego, CA 92134-5000, USABrenda L. Nelson, Department of Anatomic Pathology, Naval Med... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5212530 Tue, 06 Sep 2011 15:43:09 +0100 5212530 http://www.medworm.com/index.php?rid=5198470&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fkx27q240x8811wjg%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s12105-011-0299-2Authors Thomas Daley, HSA412 Division of Oral Pathology, Department of Pathology, University of Western Ontario, London, ON N6A 5C1, CanadaMark Darling, HSA412 Division of Oral Pathology, Department of Pathology, University of Western Ontario, London, ON N6A 5C1, Canada Journal Head and Neck PathologyOnline ISSN 1936-0568Print ISSN 1936-055X (Source: Head and Neck Pathology) Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5198470 Mon, 05 Sep 2011 16:15:24 +0100 5198470 http://www.medworm.com/index.php?rid=5198471&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy323125865v10368%2F Abstract  Tumor depth of invasion (DOI) is a histologic feature that consistently correlates with lymph node metastasis; however, there are many difficulties with accurately assessing DOI. The aim of this study was to identify a simpler and more reproducible method of determining DOI, by using skeletal muscle invasion as a surrogate marker of depth. Oral tongue squamous cell carcinoma American Joint Committee on Cancer (AJCC) stage T1 cases were identified in the Emory University Department of Pathology database. 61 cases, with a minimum of 2 years of follow-up, were included in the study. Cases were examined histologically to assess muscle invasion and DOI. The two methods of measurement were analyzed to determine the positive predictive value (PPV) of DOI or muscle i... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5198471 Sun, 04 Sep 2011 10:54:09 +0100 5198471 http://www.medworm.com/index.php?rid=5198472&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff643634m0838u255%2F Content Type Journal ArticleCategory American Academy of Oral and Maxillofacial Pathology 65th Annual Meeting, San Juan, Puerto RicoPages 1-4DOI 10.1007/s12105-011-0294-7Authors James Rokos, Department of Oral Pathology, Medicine, and Radiology, University of Missouri Kansas City, School of Dentistry, Kansas City, MO, USARomán Carlos, Division of Oral and Maxillofacial Pathology, Centro Clínico de Cabeza y Cuello/Hospital Herrera Llerandi, Guatemala City, GuatemalaMário José Romañach, Oral Pathology Section, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil Journal Head and Neck PathologyOnline ISSN 1936-0568Print ISSN 1936-055X (Source: Head and Neck Pathology) Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5198472 Sun, 04 Sep 2011 10:54:08 +0100 5198472 http://www.medworm.com/index.php?rid=5186284&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj828m42u40422003%2F Content Type Journal ArticleCategory American Academy of Oral and Maxillofacial Pathology 65th Annual Meeting, San Juan, Puerto RicoPages 1-6DOI 10.1007/s12105-011-0295-6Authors Z. B. Kurago, Oral and Maxillofacial Pathology, Radiology and Medicine, NYU College of Dentistry, New York, NY, USAA. R. Kerr, Oral and Maxillofacial Pathology, Radiology and Medicine, NYU College of Dentistry, New York, NY, USAN. Narayana, UNMC, College of Dentistry, Lincoln, NE, USA Journal Head and Neck PathologyOnline ISSN 1936-0568Print ISSN 1936-055X (Source: Head and Neck Pathology) Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5186284 Wed, 31 Aug 2011 05:52:19 +0100 5186284 http://www.medworm.com/index.php?rid=5186285&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F748042nwq075640u%2F This report presents a case of palate pigmentation related to the prolonged use of chloroquine diphosphate caused by the deposition of drug metabolites in the mucosa. Healthcare professionals must be aware of these drugs and their adverse effects in order to make the correct diagnosis, decide on the optimal treatment for the condition, or refer the patient to an appropriate specialist. Content Type Journal ArticleCategory Sine qua non Clinicopathologic CorrelatPages 1-3DOI 10.1007/s12105-011-0288-5Authors Mário Rodrigues de Melo Filho, Department of Dentistry, State University of Montes Claros, Montes Claros, Minas Gerais, BrazilCélsia Adriane Dias da Silva, DDS, State University of Montes Claros, Unimontes, Montes Claros, Minas Gerais, BrazilMaurício da Rocha Dourado, DDS, St... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5186285 Tue, 30 Aug 2011 05:42:40 +0100 5186285 http://www.medworm.com/index.php?rid=5171682&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7v21rk0064512873%2F Content Type Journal ArticleCategory American Academy of Oral and Maxillofacial Pathology 65th Annual Meeting, San Juan, Puerto RicoPages 1-3DOI 10.1007/s12105-011-0290-yAuthors John E. Kacher, JKJ Pathology, 4223 Research Forest Dr., Ste 500, The Woodlands, TX 77381, USAElizabeth Philipone, Department of Oral Pathology, Columbia University, 630 W. 168th St, PH15 W-1562, New York, NY 10032, USA Journal Head and Neck PathologyOnline ISSN 1936-0568Print ISSN 1936-055X (Source: Head and Neck Pathology) Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5171682 Sat, 27 Aug 2011 15:47:23 +0100 5171682 http://www.medworm.com/index.php?rid=5149079&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq80lr0730r04q516%2F Content Type Journal ArticleCategory American Academy of Oral and Maxillofacial Pathology 65th Annual Meeting, San Juan, Puerto RicoPages 1-5DOI 10.1007/s12105-011-0292-9Authors Darren Cox, Department of Pathology and Medicine, Arthur A. Dugoni School of Dentistry, University of the Pacific, San Francisco, CA 94115, USAChristel Haberland, Pediatric Dentistry, Yale-New Haven Hospital, Hamden, CT 06514, USA Journal Head and Neck PathologyOnline ISSN 1936-0568Print ISSN 1936-055X (Source: Head and Neck Pathology) Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5149079 Mon, 22 Aug 2011 15:57:33 +0100 5149079 http://www.medworm.com/index.php?rid=5149080&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F07419170n631217k%2F Content Type Journal ArticleCategory American Academy of Oral and Maxillofacial Pathology 65th Annual Meeting, San Juan, Puerto RicoPages 1-5DOI 10.1007/s12105-011-0291-xAuthors Susan Müller, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USASiema Eljack, Hackensack University Medical Center, Hackensack, NJ, USAJohn M. DelGaudio, Department of Otolaryngology Head and Neck Surgery, Emory University School of Medicine, Atlanta, GA 30322, USA Journal Head and Neck PathologyOnline ISSN 1936-0568Print ISSN 1936-055X (Source: Head and Neck Pathology) Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5149080 Mon, 22 Aug 2011 15:57:32 +0100 5149080 http://www.medworm.com/index.php?rid=5149081&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fpk40225721671018%2F Abstract  Intraoral nodular nodular fasciitis is a rare entity that is important to recognize because it may simulate a malignancy clinically and histologically. The rapid growth and high mitotic index seen in nodular fasciitis may suggest a malignant neoplastic process, but it is generally considered to be a benign reactive proliferation. Recognizing the unique histologic features of nodular fasciitis is important to avoid a possible misdiagnosis as a malignancy, leading to unnecessary further treatment. Content Type Journal ArticleCategory American Academy of Oral and Maxillofacial Pathology 65th Annual Meeting, San Juan, Puerto RicoPages 1-5DOI 10.1007/s12105-011-0289-4Authors Aparna Naidu, Texas A&M Health Science Center-Baylor College of Dentistry, 3302 Gaston Ave.... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5149081 Mon, 22 Aug 2011 15:57:31 +0100 5149081 http://www.medworm.com/index.php?rid=5149082&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F636v233605g73080%2F Abstract  Xanthogranulomatous inflammation (XGI) is a special type of inflammation presenting as mass lesions and mimicking malignant tumors. It is rarely described in the head and neck region, and to the best of our knowledge, there are no cases associated with branchial cleft cyst. A 39-year-old woman with an infiltrative cystic neck mass that radiologically mimicks a malignant tumor is herein presented. The histopathologic diagnosis was a branchial cleft cyst with XGI. XGI may be associated wih branchial cleft cysts. Patients may present with radiologic findings mimicking an invasive malignant tumor, and should be taken into account during the differential diagnosis with cystic squamous cell carcinoma. Content Type Journal ArticleCategory Case ReportPages 1-4DOI 10.1... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5149082 Thu, 18 Aug 2011 05:50:36 +0100 5149082 http://www.medworm.com/index.php?rid=5081975&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fbp8251125t215803%2F Abstract  The aim of this study was to describe the clinical features of 18 cases of metastatic tumors to the oral cavity. The files of patients seen between 1992 and 2009 with oral (soft tissue and jawbones) metastatic lesions were reviewed. Clinical features, including gender, age, site of the primary tumor, site of metastatic tumor and treatment were evaluated. Patients were 11 males and 7 females, with mean age of 64.6 years. In males, most primary tumors originated in the lungs. In females, the lung and breast were the most common sites of the primary tumors. The mandible was the main site for the development of the metastatic lesions and the most common histologic type was adenocarcinoma. Treatment modalities included radiotherapy, chemotherapy and surgical resec... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5081975 Sat, 30 Jul 2011 15:52:46 +0100 5081975 http://www.medworm.com/index.php?rid=5081976&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2635714813301874%2F Abstract  Sinonasal undifferentiated carcinoma (SNUC) is an uncommon and highly aggressive neoplasm of the paranasal sinuses and nasal cavity. Its undifferentiated histologic appearance often requires immunohistochemical studies to distinguish it from other high-grade neoplasms. Due to the rarity of SNUC, its immunohistochemical staining profile has been incompletely characterized, and little work has been done on its expression of the markers for human papillomavirus (HPV). Our objective is to expand our knowledge of its immunophenotype and its association with HPV in order to define markers with mechanistic potential in the disease process, or of possible therapeutic importance. A total of five patients (one woman and four men) with SNUC, ranging in age from 26 to 75&nbsp... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5081976 Fri, 29 Jul 2011 16:06:11 +0100 5081976 http://www.medworm.com/index.php?rid=5065420&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa67r732877702703%2F This study has compared the polymerase chain reaction (PCR), chromogenic in situ hybridization (CISH), and p16INK4a immunohistochemistry in the assessment of HPV status in TSCC. Archival specimens of TSCC from thirty patients were investigated. HPV was detected by PCR in 25/30 (83.3%) tumors; HPV16 (70.0%) and HPV52 (6.7%) were the most common types. HPV was corroborated by CISH in 22/25 (88.0%) specimens; integrated HPV was implicated by the presence of punctate signals in each of these cases. p16INK4a staining was found in 20/22 (90.9%) HPV PCR positive samples; two PCR/CISH HPV positive cases were p16INK4a negative and two HPV negative samples were p16INK4a positive. These data suggest that a minority of HPV positive TSCCs are positive for passenger HPV and that two or more assays m... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5065420 Sat, 23 Jul 2011 15:48:11 +0100 5065420 http://www.medworm.com/index.php?rid=5058660&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy4wl05n770374424%2F Abstract  Intravascular fasciitis (IF) is an unusual variant of nodular fasciitis. It is characterized by intraluminal, intramural, and extramural involvement of small to large arteries or veins. Only three cases involving the oral cavity have been reported previously in the literature. Here we present an additional case of oral IF arising in the submucosa of the upper lip of a 20-year old female. Microscopic examination showed a well-circumscribed, nodular proliferation of spindle cells arranged in intersecting fascicles. Occasional multinucleated giants cells also were noted. The tumor was present within the lumen of an intermediate-sized artery and extended into adjacent smaller vessels, thereby creating a multinodular appearance. Extramural extension into the surroundin... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5058660 Thu, 21 Jul 2011 18:04:31 +0100 5058660 http://www.medworm.com/index.php?rid=5058661&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fhut864483vk43837%2F We present the first case (male, 35 years old) of a mammary analogue secretory carcinoma occurring in a submandibular gland and document findings on fine needle aspiration cytology. On histology, the tumor displayed characteristic features: circumscribed nodules composed of bland, pink to light red neoplastic cells with low proliferative/mitotic activity arranged in tubular, vaguely cribriform, and microcystic structures containing Periodic acid Schiff-positive, diastase-resistant secretory material. Immunohistochemistry showed strong and diffuse positivity for cytokeratin 7, S100 protein, and vimentin, as well as moderate to strong immunoreactivity for c-kit in the majority of tumor cells. A rearrangement of the ETV6 gene on fluorescence in situ hybridization was documented. The... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5058661 Wed, 20 Jul 2011 12:28:01 +0100 5058661 http://www.medworm.com/index.php?rid=5032307&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fkgt14446102u6622%2F Abstract  Sixty-five cases of odontogenic fibroma (OdonF) are herein presented having been segregated into peripheral, extra bony tumors (n = 40) and tumors arising in bone or centrally (n = 25). All cases were characterized microscopically by a fibrous proliferation that varied within and between cases in cellularity and collagen fibril diameter, with intermixed odontogenic epithelial islands and cords. All central lesions presented as well demarcated radiolucencies and resorption of contiguous tooth roots was a common finding. These intraosseous lesions were of the WHO type; the so-called nonWHO type was excluded as all lesions with this diagnosis were devoid of an epithelial component and could be reclassified as other soft tissue fibrogenic tumors. Ne... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5032307 Wed, 13 Jul 2011 06:12:28 +0100 5032307 http://www.medworm.com/index.php?rid=5012714&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F35238v8357883222%2F Abstract  Focal osseous dysplasia (FOD) is one of the benign fibro-osseous lesions of the jaw bones and the most commonly occuring benign fibro-osseous lesion. This entity occurs more commonly in females and has a predilection for African Americans. Radiographically, the lesion has a variable appearance depending on the duration but may appear as a radiolucent to radiopaque lesion that can be well to poorly defined. Hisotologically, when biopsied, there are fragments of bony trabeculae intermixed with fibrous stroma with incomplete stromal vasculature. The main differential diagnosis is with ossifying fibroma, which is neoplastic while FOD is considered a reactive process. Most patients with FOD may be followed clinically without surgical intervention. Content Type Jour... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5012714 Sat, 09 Jul 2011 06:19:26 +0100 5012714 http://www.medworm.com/index.php?rid=5012715&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj1k0434ng5qx53j8%2F This study intends to review the literature and highlight the current clinical and molecular perspectives about this entity. The most common clinical presentation of CA ex PA is of a firm mass in the parotid gland. The proportion of adenoma and carcinoma components determines the macroscopic features of this neoplasm. The entity is difficult to diagnose pre-operatively. Pathologic assessment is the gold standard for making the diagnosis. Treatment for Ca ex PA often involves an ablative surgical procedure which may be followed by radiotherapy. Overall, patients with Ca ex PA have a poor prognosis. Accurate diagnosis and aggressive surgical management of patients presenting with Ca ex PA can increase their survival rates. Molecular studies have revealed that the development of Ca ex P... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=5012715 Sat, 09 Jul 2011 06:19:25 +0100 5012715 http://www.medworm.com/index.php?rid=4994941&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fpv478w77202j7771%2F We report a case of HTT in a 69-year-old woman with a mutinodular goiter. Since the clinical and ultrasonographic features were nonspecific, fine needle aspiration biopsy (FNAB) of the left lobe-dominant node was performed that resulted in an indeterminate cytologic diagnosis (category THY-3). The patient underwent total thyroidectomy, with a histologic diagnosis of HTT. We discuss the clinical and diagnostic approach, including the role of FNAB, and the pathologic features of HTT with special reference to the possible differential diagnosis. Total thyroidectomy or hemithyroidectomy represent adequate treatments, while radioiodine ablation is not standard. Although rare cases of malignant HTT have been documented, this tumor should be considered a benign neoplasm or, at most, a neop... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4994941 Thu, 30 Jun 2011 17:49:02 +0100 4994941 http://www.medworm.com/index.php?rid=4963479&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ffu11971123044015%2F Abstract  Lymphoepithelial carcinoma (LEC) is a rare malignancy. Histologically, it is an undifferentiated carcinoma with an intermixed reactive lymphoplasmacytic infiltrate. Herein, we report two cases of LEC in the head and neck region that presented to Oulu University Hospital. Our first case is a 30-year-old man with LEC in the left maxillary sinus. The second case is a 49-year-old man with LEC in the soft palate and uvula with regional lymph node metastases at diagnosis. In addition, a systematic review of the literature from 1980 to 2010 was performed with MEDLINE and cross-references were searched manually. Case reports and clinical series of oral, oropharyngeal, nasal, and paranasal sinus LECs were reviewed revealing a total of 110 cases. Most of the oral cases were... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4963479 Wed, 22 Jun 2011 15:58:43 +0100 4963479 http://www.medworm.com/index.php?rid=4963481&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv2q18737447q2282%2F Content Type Journal ArticlePages 1-4DOI 10.1007/s12105-011-0275-xAuthors James T. Castle, Department Of Oral and Maxillofacial Pathology, Naval Postgraduate Dental School, NMMPT&E, Bethesda, MD 20889-5611, USAMikelle L. Kernig, Oral and Maxillofacial Pathology, Wright-Patterson AFB, Dayton, OH 45433, USA Journal Head and Neck PathologyOnline ISSN 1936-0568Print ISSN 1936-055X (Source: Head and Neck Pathology) Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4963481 Tue, 21 Jun 2011 18:33:58 +0100 4963481 http://www.medworm.com/index.php?rid=4963480&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5653127w80n80452%2F We present an example of a rare FUS-positive SEF that arose in the floor of mouth of a 56 year old male. Light microscopy, exhaustive immunohistology, and FISH examination showing chromosome rearrangement using the FUS break-apart probe led to an erroneous diagnosis of LGFMS with giant collagen rosettes. An outside expert agreed with that diagnosis citing the FISH results as confirmatory. Upon review almost 2 years later after local recurrence, the classic histopathologic features of SEF were noted instead. This example suggests that at least a subset if not most examples of SEF are part of the LGFMS “family” of neoplasms, and reiterates the value of careful histologic examination in an age of increasingly sophisticated and presumably specific molecular results. Co... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4963480 Tue, 21 Jun 2011 18:33:58 +0100 4963480 http://www.medworm.com/index.php?rid=4948009&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F644j201103366183%2F Abstract  Elastofibromas of the oral cavity are rare, with only 5 cases reported. In this paper, we present a series of five new cases of oral elastofibromatous lesions, occurring in 4 males and 1 female, with ages ranging from 33 to 76 years. The clinical differential diagnosis includes fibroepithelial polyp or fibroma, among other connective tissue tumours. Elastofibromas probably develop as reactive lesions, for which surgical treatment is definitive. Content Type Journal ArticlePages 1-5DOI 10.1007/s12105-011-0274-yAuthors Mark R. Darling, Division of Oral Pathology, Department of Pathology, University of Western Ontario, London, ON N6A 5C1, CanadaMaciej Kutalowski, Division of Oral Pathology, Department of Pathology, University of Western Ontario, London, ON N... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4948009 Fri, 17 Jun 2011 12:02:15 +0100 4948009 http://www.medworm.com/index.php?rid=4948008&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe6005865m4357312%2F Abstract  Herein we present a case of a bronchogenic cyst masquerading as a thyroid mass. Bronchogenic cysts are rare congenital malformations that result from an abnormal development of the ventral foregut during organogenesis. They are commonly asymptomatic lesions rarely found in the neck. In our case, a young male presented with complaints of neck discomfort over a long period presumed to be secondary to a thyroid mass based on imaging studies. Fine needle aspiration was inconclusive. Post-operative pathological sectioning revealed evidence of a bronchogenic cyst. These lesions have a low incidence of malignancy, and complete surgical excision has been recommended. Content Type Journal ArticlePages 1-3DOI 10.1007/s12105-011-0272-0Authors Alagappan Annamalai, New Y... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4948008 Fri, 17 Jun 2011 12:02:15 +0100 4948008 http://www.medworm.com/index.php?rid=4948007&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F700k53g374234r02%2F We report a case of 53-year-old man with a progressively enlarging lump in the left submandibular region. Ultrasound examination revealed a cystic mass with an intraluminal fluid collection. The tumor was surgically removed. Histologic examination yielded a diagnosis of oncocytic cystadenoma with a high concentration of intraluminal crystalloids. The microscopic features of the crystalloids were compatible with nontyrosine (alpha-amylase) crystalloids. When compared with previously published cases in the literature, this is the first report of oncocytic cystadenoma with intraluminal crystalloids arising in the submandibular gland, and the second reported case of the nontyrosine type of crystalloids occurring in association with this tumor. The nontyrosine crystalloids may be highly c... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4948007 Fri, 17 Jun 2011 12:02:15 +0100 4948007 http://www.medworm.com/index.php?rid=4916095&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F163m87w2127166t3%2F Abstract  The aim of this study was to evaluate the immunohistochemical expression of molecules involved in osteoclastogenesis, including the receptor activator of nuclear factor kappa B (RANK), RANK ligand (RANKL) and osteoprotegerin (OPG) in odontogenic keratocysts (OKCs), which has been named as a keratocystic odontogenic tumour by the WHO, and compare their expression with radicular cysts and ameloblastomas. RANK is a member of tumour necrosis factor receptor family and it is activated by RANK ligand. OPG binds to RANKL and inactivates it. The imbalance of these factors could cause the differential bone resorption activity in some diseases and tumours. The expression of these molecules was evaluated in ameloblastomas (n = 20), OKCs (n = 20), and radic... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4916095 Sun, 05 Jun 2011 05:46:32 +0100 4916095 http://www.medworm.com/index.php?rid=4916096&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl031n5tl117q561v%2F Abstract  Carcinoma cuniculatum (CC) is a rare, distinct clinico-pathological variant of squamous cell carcinoma (SCC) that is defined histologically by the characteristic infiltrative pattern of a deep, broad, and complex proliferation of stratified squamous epithelium with keratin cores and keratin-filled crypts. Herein, we present a case report of CC of the oral tongue and discuss its diagnosis, management, and outcome, as well as briefly review the world literature. To our knowledge, this is the first documented case of CC of the tongue to be reported in the English literature. We draw attention to its clinico-pathological features and highlight that awareness of this entity as a distinct variant of SCC facilitates its correct management. Content Type Journal Articl... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4916096 Sat, 04 Jun 2011 05:53:17 +0100 4916096 http://www.medworm.com/index.php?rid=4897443&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr250102702vw54l6%2F Abstract  PEComas are a family of neoplastic lesions that share overlapping morphology, immunohistochemistry, and ultrastructure that include angiomyolipoma, lymphangioleiomyomatosis, clear cell “sugar” tumor of the lung as well as similar tumors occurring in a variety of visceral, cutaneous and soft tissue sites throughout the body. The defining histopathological features are epithelioid cells with a perivascular distribution containing clear to pale eosinophilic granular cytoplasm and a round-to-oval centrally located nucleus with an inconspicuous nucleolus. Immunohistochemically, coexpression of melanocytic (HMB-45 and/or Melan-A) and myoid markers are characteristic. In the present study, we describe three PEComas occurring in the head and neck (nasal cavity and lar... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4897443 Mon, 30 May 2011 17:02:11 +0100 4897443 http://www.medworm.com/index.php?rid=4897444&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Frl39705v7uq8t726%2F Abstract  The sinonasal tract is a complex anatomic site, home to a wide variety of reactive, inflammatory, benign, and malignant lesions. Inflammatory polyps and papillomas are usually easily recognized by pathologists. A poorly understood lesion that has been more clearly defined in recent years is the nasal hamartoma. The epithelial subtypes include seromucinous hamartoma, respiratory epithelial adenomatoid hamartoma, and hybrid lesions. Seromucinous hamartomas have only been recognized and substantially reported over the past few years. They are a diagnostic challenge, needing to be distinguished from low grade adenocarcinomas, and are of interest because most of the basic questions about their pathophysiology remain unanswered. Herein, we present two novel cases of ser... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4897444 Thu, 26 May 2011 16:09:13 +0100 4897444 http://www.medworm.com/index.php?rid=4849266&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv637p841p3631533%2F We report our experience of a solitary pulmonary adenocarcinoma metastasis that arose within a pre-existing basal cell carcinoma in a patient with undiagnosed lung cancer. Immunohistochemistry was invaluable in confirming both the metastatic nature of the secondary skin lesion and its site of origin. Content Type Journal ArticlePages 1-3DOI 10.1007/s12105-011-0263-1Authors Elinor Carey, Royal Gwent Hospital, Newport, Wales, UKSimon D. Jones, ABM University NHS Trust, Morriston Hospital, Swansea, Wales, UKPaul Griffiths, ABM University NHS Trust, Morriston Hospital, Swansea, Wales, UKPrue Baxter, ABM University NHS Trust, Morriston Hospital, Swansea, Wales, UK Journal Head and Neck PathologyOnline ISSN 1936-0568Print ISSN 1936-055X (Source: Head and Neck Pathology) Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4849266 Thu, 19 May 2011 16:35:01 +0100 4849266 http://www.medworm.com/index.php?rid=4834837&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F014ut0632265343w%2F We present a case in a two-year-old male with a one-month swelling of the right mandible without significant medical history or diagnosis of hemophilia who was subsequently diagnosed as having Factor IX deficiency, or hemophilia B. A review of the literature revealed only 15 reported cases of PTH of the jaws and salient features of PTH in the jaws are discussed. The differential diagnosis of masses occurring in the jaws of children is limited and PTH should be considered when a mass presents with rapid growth and the histopathologic features are not diagnostic for a neoplastic process, even in the absence of a prior diagnosis of hemophilia as PTH may be the initial manifestation of this disease. Content Type Journal ArticlePages 1-7DOI 10.1007/s12105-011-0267-xAuthors D. P. Cox... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4834837 Thu, 12 May 2011 16:45:06 +0100 4834837 http://www.medworm.com/index.php?rid=4823806&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3u7r32256rx559l1%2F We present a case of adenoid cystic carcinoma of the larynx arising in the inter-arytenoid and postcricoid region in a 54-year-old woman. To our knowledge, this is the first case of adenoid cystic carcinoma arising in this particular region of the larynx. Content Type Journal ArticlePages 1-3DOI 10.1007/s12105-011-0266-yAuthors Ozlem Saraydaroglu, Department of Pathology, Uludag University Medical School, 16059 Bursa, TurkeyHakan Coskun, Department of Otorhinolaryngology and Head-Neck Surgery, Uludag University Medical School, Bursa, TurkeyMehtap Kasap, Department of Pathology, Uludag University Medical School, 16059 Bursa, Turkey Journal Head and Neck PathologyOnline ISSN 1936-0568Print ISSN 1936-055X (Source: Head and Neck Pathology) Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4823806 Wed, 11 May 2011 05:51:28 +0100 4823806 http://www.medworm.com/index.php?rid=4823805&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb8763n2403484g50%2F This study was undertaken to expand our understanding of the processes involved in fibrosis that occurs in chronic sclerosing sialadenitis (CSS) by investigating the distribution of tenascin-C. Fifteen specimens of CSS with varying degrees of fibrosis and five normal submandibular glands were retrospectively examined immunohistochemically for the distribution of TNC. Linear deposition of TNC was found around collecting ducts in normal glands and around collecting ducts without surrounding fibrotic tissue in CSS; percentage incidences were not statistically different. In contrast, broader, band-like deposition of TNC was found in the fibrous tissue around collecting ducts in CSS with widespread degree of fibrosis compared to little or no fibrosis; the percentage incidence was statisti... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4823805 Wed, 11 May 2011 05:51:28 +0100 4823805 http://www.medworm.com/index.php?rid=4769091&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1344875284403183%2F In this report, we review the literature of these unusual lesions and compare them to cases of conventional malakoplakia involving the large airways. We also explore the pathogenetic mechanisms that may contribute to the distinctive histologic appearance of Rhodococcus-associated pseudotumors. Content Type Journal ArticlePages 1-6DOI 10.1007/s12105-011-0259-xAuthors Shreeram Akilesh, Department of Pathology and Immunology, Barnes-Jewish Hospital, St. Louis, MO 63110, USASara Cross, Department of Internal Medicine, Division of Infectious Diseases, Barnes-Jewish Hospital, St. Louis, MO 63110, USAKatherine Kimmelshue, Department of Pathology and Immunology, Barnes-Jewish Hospital, St. Louis, MO 63110, USANigar Kirmani, Department of Internal Medicine, Division of Infectious Diseases,... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4769091 Mon, 25 Apr 2011 16:43:25 +0100 4769091 http://www.medworm.com/index.php?rid=4750059&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fyl655488105l732h%2F Abstract  Isolated orbital infantile myofibroma are rare tumors in the head and neck. The mass-like clinical presentation and variable histologic features result in frequent misdiagnosis and potentially inappropriate clinical management. There are only a few reported cases in the English literature. Twenty-four patients with orbital infantile myofibroma or myofibromatosis were compiled from the English literature (Medline 1960–2011) and integrated with this case report. The patients included 14 males and 10 females, aged newborn to 10 years (mean, 34.8 months), who presented with a painless mass in the infra- or supraorbital regions, usually increasing in size andassociated with exophthalmos (n = 5). Females were on average older than their male counter... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4750059 Thu, 21 Apr 2011 18:01:26 +0100 4750059 http://www.medworm.com/index.php?rid=4750058&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy25970531qx87462%2F Abstract  The intraoperative knowledge of margin status on mandibulectomy specimens is important for primary reconstruction. The goal of this study was to evaluate whether intraoperative bone marrow (BM) curettings and inferior alveolar nerve (IAN) biopsies are representative of final decalcified cross-sectional (shave) mandibular bone margins. Forty-seven margins in 27 patients consecutively treated with segmental mandibulectomy for squamous cell carcinoma were reviewed. These patients had BM or IAN margins sampled by surgeons and assessed intraoperatively by routine frozen section. The full cross-section of mandibular bone margins were sampled by pathologists at the time of routine gross examination. Intraoperative evaluation of BM/IAN biopsies is characterized by a 50% s... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4750058 Thu, 21 Apr 2011 18:01:26 +0100 4750058 http://www.medworm.com/index.php?rid=4745540&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F51m1746773g2u274%2F Conclusions  Carcinomatous transformation of a PA in the nasal cavity is extremely rare, but does occur. Accordingly, PAs of this site should be thoroughly sampled and closely examined to exclude the possibility of malignant transformation. Content Type Journal ArticlePages 1-5DOI 10.1007/s12105-011-0262-2Authors Ashley Cimino-Mathews, Department of Pathology, The Johns Hopkins Medical Institutions, 600N. Wolfe St., Pathology Building 401, Baltimore, MD 21287, USABrian M. Lin, School of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD, USASteven S. Chang, Department of Facial Plastic and Reconstructive Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD, USAKofi D. Boahene, Department of Facial Plastic and Reconstructive Surgery, The Johns Ho... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4745540 Wed, 20 Apr 2011 06:08:17 +0100 4745540 http://www.medworm.com/index.php?rid=4745539&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd30707744m831617%2F We present a case of a 36-year-old female with a benign fibro-osseous lesion consistent with cemento-osseous dysplasia (COD) that was located coronally to the crown of an impacted mandibular third molar tooth and was associated with a complex odontoma. The pathogenesis of this unusual association is discussed and the odontogenic origin of COD is suggested. Content Type Journal ArticlePages 1-4DOI 10.1007/s12105-011-0261-3Authors Georgios I. Prodromidis, Department of Oral Pathology, Faculty of Dentistry, National and Kapodistrian University of Athens, Athens, GreeceKonstantinos I. Tosios, Department of Oral Pathology, Faculty of Dentistry, National and Kapodistrian University of Athens, Athens, GreeceIoannis G. Koutlas, Division of Oral Pathology, School of Dentistry, University o... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4745539 Wed, 20 Apr 2011 06:08:17 +0100 4745539 http://www.medworm.com/index.php?rid=4647239&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4n45l4v00224j58n%2F This report describes, for the first time, an entirely intranodal location for a low-grade intraductal carcinoma (so-called low-grade cribriform cystadenocarcinoma). Content Type Journal ArticlePages 1-5DOI 10.1007/s12105-011-0256-0Authors Ilan Weinreb, Department of Pathology, University Health Network and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G 2C4, Canada Journal Head and Neck PathologyOnline ISSN 1936-0568Print ISSN 1936-055X (Source: Head and Neck Pathology) Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4647239 Fri, 25 Mar 2011 18:52:20 +0100 4647239 http://www.medworm.com/index.php?rid=4647240&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk18183j7688g17h8%2F We describe a case of an EBV-positive plasmacytoma presenting as a 7.7 cm submandibular mass in an elderly immunocompetent man which displayed an abundance of “naked nuclei” on fine needle aspiration cytology. The tumor showed lambda light chain restriction and positive expression for CD38, MUM1 and EBER. Subsequent investigation for myeloma revealed absence of M-protein and end-organ damage, except for a lytic lesion in the radial bone. An extensive fluorescent in situ hybridization analysis showed the tumor to be negative for the t(4;14) FGFR3/IGH translocation as well as translocations involving the IGH, IGL, IGK, CCND1, BCL2, BCL6 and C-MYC genes. KRAS genetic analysis did not reveal any mutations of codons 12, 13 and 61. Content Type Journal ArticlePages 1-6DOI 10.1... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4647240 Fri, 25 Mar 2011 18:52:16 +0100 4647240 http://www.medworm.com/index.php?rid=4618269&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn785148p83141978%2F Abstract  A case (female, 39 years of) of thyroid-like nasopharyngeal low-grade papillary adenocarcinoma with a significant spindle cell component is presented. The tumor was located on the posterior nasal septum. The spindle cells displayed nuclear features very much similar to the epithelial component and the two cell types merged imperceptibly. Immunohistochemically, the neoplastic cells (including the spindle cell component) were strongly and diffusely positive for TTF-1, cytokeratins (AE1-3), cytokeratin 19 and vimentin. C-kit immunohistochemistry showed diffuse mild to moderate membranous positivity with focal areas displaying moderate to strong immunoreactivity. EMA was strongly positive in the epithelial component with membranous and cytoplasmic reactivity wher... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4618269 Sat, 19 Mar 2011 16:56:49 +0100 4618269 http://www.medworm.com/index.php?rid=4618271&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy068mm65415271u5%2F Abstract  Unlike its cutaneous counterpart, prognostic markers for primary mucosal malignant melanoma have not been well elucidated. It has been recently demonstrated that microvascular density (MVD) in cutaneous malignant melanoma has a significant negative correlation with survival; however, this has not been well-studied in mucosal malignant melanoma of the head and neck. This study explores the potential association between MVD, various histological parameters, and the outcome of a series of sinonasal and oral mucosal melanomas. Nineteen such cases were immunostained with CD31 and the MVD was calculated by using Bioquant Image Analysis Software (R and M Biometrics, Nashville, TN). These cases included 16 sinonasal and 3 oral cavity tumors. The 1, 2, 3, 4 and 5 year... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4618271 Sat, 19 Mar 2011 02:52:49 +0100 4618271 http://www.medworm.com/index.php?rid=4618270&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fyhn1768232r627l5%2F We report two unusual cases of solitary fibrous tumor (SFT) of minor salivary glands that microscopically mimicked pleomorphic adenoma. One of these lesions presented in the retromolar region and the other in the buccal mucosa. The microscopic features of these two tumors and their intimate relationship with regional mucous minor salivary glands posed a diagnostic challenge. Awareness of the morphological diversity of SFT coupled to a judicious use of appropriate immunohistochemical probes should prove valuable to accurately segregate SFT from pleomorphic adenoma. Content Type Journal ArticlePages 1-7DOI 10.1007/s12105-011-0254-2Authors Jose Luis Tapia, Department of Oral Diagnostic Sciences, School of Dental Medicine, University at Buffalo, 3435 Main Street, 355 Squire Hall, Bu... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4618270 Sat, 19 Mar 2011 02:52:49 +0100 4618270 http://www.medworm.com/index.php?rid=4562842&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy2329517v2826q47%2F Abstract  The number of published cases of adenomatoid odontogenic tumor (AOT) has steadily increased, and about half were reported in Asian populations. Although the clinicopathologic profile of AOT has been extensively reported, factual knowledge of its pathogenesis is rudimentary at best, and there is controversy as to precisely which odontogenic epithelium it arises from. AOT is a successional tooth-associated lesion which develops during the mixed dentition. The permanent successor differs from its deciduous predecessor in that it has an eruptive pathway from the dental follicle to the gingiva, the gubernaculum dentis. With this background in mind, the present review focuses mainly on the early development of AOT. We successfully demonstrated a close spatial relationsh... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4562842 Sat, 05 Mar 2011 16:51:00 +0100 4562842 http://www.medworm.com/index.php?rid=4509102&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe22301j1526774g2%2F Conclusion  This case highlights the possibility of oral manifestations as the only sign of AL and reveals the unexpected co-existence of AL and NF 2, for the first time. Content Type Journal ArticlePages 1-4DOI 10.1007/s12105-011-0251-5Authors Dimitrios Andreadis, Department of Oral Medicine/Pathology, School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceAthanasios Poulopoulos, Department of Oral Medicine/Pathology, School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreecePetros Papadopoulos, Department of Oral Medicine/Pathology, School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceApostolos Epivatianos, Department of Oral Medicine/Pathology, School of Dentistry, Aristotle Un... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4509102 Mon, 21 Feb 2011 17:08:42 +0100 4509102 http://www.medworm.com/index.php?rid=4491713&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F12xh7k0v1517n533%2F We report one such case of a female patient who presented with a persistent upper lip enlargement. She had visited multiple general dental practitioners and general physicians but was undiagnosed. Ultrasonography proved an adjunctive tool in diagnosis. She was treated with a combination of topical and intra-lesional steroids. A 1 year follow-up did not show any evidence of recurrence. Content Type Journal ArticlePages 1-4DOI 10.1007/s12105-011-0249-zAuthors Titus K. Thomas, Department of Oral and Maxillofacial Surgery, Meenakshi Ammal Dental College & Hospital, Alapakkam Main Road, Maduravoyal, Chennai, IndiaR. S. Neelakandan, Department of Oral and Maxillofacial Surgery, Meenakshi Ammal Dental College & Hospital, Alapakkam Main Road, Maduravoyal, Chennai, IndiaDarpan Bharga... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4491713 Wed, 16 Feb 2011 07:00:13 +0100 4491713 http://www.medworm.com/index.php?rid=4491715&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F030581345t8p48pm%2F Abstract  In this case report, we describe an unusual case of mycobacterial associated inflammatory pseudotumor that occurred in a patient with a previous history of cocaine abuse. We discuss inflammatory pseudotumor (IPT) in general and emphasize the rare entity where an associated mycobacterial infection is seen. The histogenesis is not yet completely understood. The lesion can pose challenges for practicing pathologists and a misdiagnosis of malignancy can occur at multiple facets. A discussion about the differential diagnosis and clues to make the distinction is presented. In addition to spindle cell proliferation, the presence of a background of mixed inflammatory cell infiltrate and foamy macrophages are clues to make the diagnosis. In the case of mycobacteria associa... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4491715 Wed, 16 Feb 2011 07:00:11 +0100 4491715 http://www.medworm.com/index.php?rid=4491714&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F843831u184x8h369%2F Abstract  The calcifying epithelial odontogenic tumor is a benign epithelial tumor with characteristic clinical and histopathologic features. These features are discussed with a typical case presentation along with emphasis on newer variants and management strategies. Content Type Journal ArticlePages 1-3DOI 10.1007/s12105-011-0250-6Authors Punnya V. Angadi, Department of Oral Pathology and Microbiology, KLEVK Institute of Dental Sciences and Hospital, Belgaum, 590010 Karnataka IndiaK. Rekha, Department of Oral Pathology and Microbiology, S.D.M College of Dental Sciences and Hospital, Dharwad, 580009 Karnataka India Journal Head and Neck PathologyOnline ISSN 1936-0568Print ISSN 1936-055X (Source: Head and Neck Pathology) Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4491714 Wed, 16 Feb 2011 07:00:11 +0100 4491714 http://www.medworm.com/index.php?rid=4485824&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft613hr4712043123%2F In this study, we test the hypothesis that strong LHR corresponds to a greater degree of adaptive cytotoxic T cell response as compared to moderate LHR. We studied resection specimens of primary oral squamous carcinoma classified as having either strong (n = 16), intermediate (n = 20) or weak (n = 4) LHR. CD20+, CD4+, & CD8+ cells were detected by immunohistochemistry and quantified at 40× with a grid; counting the 10 fields with the most lymphocytes at the tumor interface and within tumors. Mean counts/tumor were analyzed by the 2-sided T-test. Statistically significant differences were observed for interface CD8 cells with respect to strong versus moderate LHR, strong versus weak LHR, and moderate versus weak LHR, and tumor infiltrating CD8 cells with ... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4485824 Mon, 14 Feb 2011 07:09:56 +0100 4485824 http://www.medworm.com/index.php?rid=4461657&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg53351061712335h%2F Abstract  Adenosquamous carcinoma (ADSC) of the head and neck is an aggressive variant of squamous cell carcinoma (SCC). Certain variants of head and neck SCC are human papillomavirus (HPV)-related and have better prognosis. The relationship of HPV to head and neck ADSC has not been investigated. We searched our files for the term “adenosquamous” and head and neck subsites and found cases from 1998 to 2009. The requisite histologic criteria were the presence of SCC combined with distinct gland formation and/or intracellular mucin. DNA in situ hybridization for high-risk HPV, RNA in situ hybridization for high risk HPV E6 and E7 transcripts, and immunohistochemistry for p16 and p53 were performed. The existing literature on ADSC was also reviewed. Of the 18 cases, eight ... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4461657 Tue, 08 Feb 2011 21:31:05 +0100 4461657 http://www.medworm.com/index.php?rid=4461658&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F84k43527021274j1%2F We report of a series of five cases with VX who concurrently had chronic oral graft-versus-host disease following hematopoietic stem cell transplantation. Content Type Journal ArticlePages 1-6DOI 10.1007/s12105-011-0246-2Authors Shokoufeh Shahrabi Farahani, Harvard School of Dental Medicine, 49 Worthington Street #7, Boston, MA 02120, USANathaniel S. Treister, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA USAZainab Khan, Harvard School of Dental Medicine, Boston, MA USASook-Bin Woo, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA USA Journal Head and Neck PathologyOnline ISSN 1936-0568Print ISSN 1936-055X (Source: Head and Neck Pathology) Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4461658 Tue, 08 Feb 2011 21:31:03 +0100 4461658 http://www.medworm.com/index.php?rid=4440059&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp854087521236746%2F In this study the clinicopathologic, histologic, and immunohistochemical features of 17 CCCs and 12 CCOCs are examined. The differential diagnosis of clear cell malignancies in the head and neck is discussed. The relationship of CCCs and CCOCs to other clear cell tumors on the basis of their immunohistochemical staining patterns is postulated. Content Type Journal ArticlePages 1-7DOI 10.1007/s12105-011-0244-4Authors Elizabeth A. Bilodeau, Department of Diagnostic Sciences, University of Pittsburgh School of Dental Medicine, 3501 Terrace St, Pittsburgh, PA 15261, USAAaron P. Hoschar, Department of Pathology, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44106, USAE. Leon Barnes, Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA USAJennifer ... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4440059 Thu, 03 Feb 2011 21:13:03 +0100 4440059 http://www.medworm.com/index.php?rid=4440060&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F788621xk1x643875%2F Abstract  Lymphoid tissue located in the head and neck region include multiple regional lymph node chains as well as mucosa associated lymphoid tissue of the conjunctiva, buccal and nasopharyngeal cavities (Waldeyer’s ring), and thyroid and salivary glands. This region is a rich source of antigenic stimuli including infectious agents coming from the outside environment. Many reactive conditions that affect lymphoid tissue in this region may mimic neoplasia. In fact, distinguishing between benign and malignant lymphoid proliferations in the head and neck region is a relatively frequent diagnostic challenge and in many instances, this distinction is not straightforward. It therefore behooves the practicing pathologist to be able to recognize the benign lymphoproliferative d... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4440060 Thu, 03 Feb 2011 21:12:54 +0100 4440060 http://www.medworm.com/index.php?rid=4440061&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F22mj6637614247u8%2F We present a case (female patient, age 45 years) with a bifocal, paucicystic variant of sclerosing polycystic adenosis of the parotid gland with cribriform ductal carcinoma in situ (DCIS) and pronounced stromal distortion affecting the in situ component to such an extent that it gave a distinct impression of intralesional invasive adenocarcinoma. P63–and calponin-positive myoepithelial cells were present in the periphery of the acini and ducts in the benign component, somewhat discontinuously in the DCIS-component, and even in the periphery of the small irregular atypical cell nests that appeared infiltrative on the haematoxylin and eosin stained sections. Strong cytoplasmic immunoreactivity for GCDFP-15 was detected in the benign component with a variable, patchy and mostly w... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4440061 Tue, 01 Feb 2011 08:40:54 +0100 4440061 http://www.medworm.com/index.php?rid=4440062&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr62228136767jlmh%2F We describe the clinical and histopathologic findings of the first case of intraoral angiomyxolipoma in a 12 year-old male, as well as the utility of immunohistochemistry as a useful tool in differential diagnosis of this particular lesion with respect to other benign and malignant lesions derived from adipose tissue. Content Type Journal ArticlePages 1-4DOI 10.1007/s12105-011-0241-7Authors Guillermo Martínez-Mata, Faculty of Dentistry, Universidad Autónoma de Chihuahua, Chihuahua, MéxicoMendoza-Farías Rocío, Oral and Maxillofacial Surgery Service, Hospital Juárez de México, Mexico City, DF, MéxicoLicéaga-Escalera Carlos Juan, Oral and Maxillofacial Surgery Service, Hospital Juárez de México, Mexico City, DF, MéxicoAlmeida Oslei Paes, Faculty of Dentistry, Univers... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4440062 Tue, 01 Feb 2011 08:40:53 +0100 4440062 http://www.medworm.com/index.php?rid=4379523&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fyt26625864jx64n2%2F Abstract  Malignancy in a setting of hyaline vascular type of Castleman’s disease (HVCD) is an exceptional occurrence. Herein, we report an extremely rare case of synchronous unicentric cervical HVCD and squamous cell carcinoma (SCC) of tongue mimicking stage IV disease. A 32-year-old gentleman presented with an ulcerated mass on the right tongue border and ipsilateral cervical nodal mass. As the clinical stage was IVB (T1N3M0), an anterior two-third glossectomy with bilateral modified neck dissection was performed. On gross examination, an ulcerated mass on the right lateral border was identified. In addition, an 8 cm large nodal mass at right level III–V was seen. Microscopy from the ulcerated growth in the tongue revealed an invasive well differentiated squamous ... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4379523 Mon, 17 Jan 2011 20:41:35 +0100 4379523 http://www.medworm.com/index.php?rid=4339917&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9p35821522x3x07g%2F Abstract  Lichenoid changes in the oral mucosa can be encountered in a wide range of lesions with varied etiologies including immune-mediated disorders, reactions to systemic medications and to dental materials. Dysplasia of the oral cavity can exhibit a lichenoid histology, which may mask the potentially cancerous component. Another unusual clinical disease, proliferative verrucous leukoplakia, can often mimic oral lichen planus clinically requiring careful correlation of the clinical and pathologic features. Content Type Journal ArticlePages 1-5DOI 10.1007/s12105-010-0237-8Authors Susan Müller, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 1364 Clifton Road NE, Atlanta, GA 30322, USA Journal Head and Neck PathologyOnline... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4339917 Mon, 10 Jan 2011 15:55:01 +0100 4339917 http://www.medworm.com/index.php?rid=4328174&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg010884022p55up3%2F Abstract  Papillary thyroid carcinomas are the most common thyroid cancers and constitute more than 70% of thyroid malignancies. The most common etiologic factor is radiation, but genetic susceptibility and other factors also contribute to the development of papillary thyroid carcinoma. The most common variants include conventional, follicular variant and tall cell variant. However, many other uncommon variants have been described including oncocytic, columnar cell, diffuse sclerosing and solid forms. Immunohistochemical staining with TTF-1 and thyroglobulin is very useful in confirming the diagnosis of papillary thyroid carcinoma especially in metastatic sites. Markers such as HBME-1 and CITED1 can assist in separating some difficult cases of follicular variants of papilla... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4328174 Fri, 07 Jan 2011 14:52:04 +0100 4328174 http://www.medworm.com/index.php?rid=4328175&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6q763q2222r6022l%2F This article reviews the clinicopathologic features of these malignancies. Ancillary testing is discussed as well as the pathologic differential diagnosis. Content Type Journal ArticlePages 1-5DOI 10.1007/s12105-010-0235-xAuthors Edward B. Stelow, Dept of Pathology, UVA Health System, University of Virginia, Jefferson Park Ave., Box 800214, Charlottesville, VA 22908, USA Journal Head and Neck PathologyOnline ISSN 1936-0568Print ISSN 1936-055X (Source: Head and Neck Pathology) Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4328175 Fri, 07 Jan 2011 14:51:59 +0100 4328175 http://www.medworm.com/index.php?rid=4328177&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd4714225n3312x8x%2F This article presents a case report of a 56-year-old man, with no previous history of trauma, who presented a slow-growing mass in the buccal mucosa. Histopathology and immunohistochemistry staining studies were performed, and a diagnosis of the desmoplastic fibroblastoma was made. The patient has been disease-free for one year. Content Type Journal ArticlePages 1-5DOI 10.1007/s12105-010-0239-6Authors Sílvia Ferreira de Sousa, Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais BrazilPatrícia Carlos Caldeira, Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais BrazilSoraya de Mattos Camargo Grossmann, Department of Oral Surg... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4328177 Fri, 07 Jan 2011 14:51:58 +0100 4328177 http://www.medworm.com/index.php?rid=4328176&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm1k4223t07719323%2F This article describes a rare case of dentigerous cyst in a 1-year-old boy, the youngest case to be documented. The clinical, radiographic and histopathologic features are discussed; the increased possibility of occurrence of these cysts at a very young age and the importance of timely diagnosis of such cysts to avoid future complications is emphasized. Content Type Journal ArticlePages 1-4DOI 10.1007/s12105-010-0238-7Authors Rakesh Suresh, Department of Oral Pathology and Microbiology, Amrita School of Dentistry, Kochi, 682041 Kerala IndiaMahija Janardhanan, Department of Oral Pathology and Microbiology, Amrita School of Dentistry, Kochi, 682041 Kerala IndiaAnna P. Joseph, Department of Oral Pathology and Microbiology, Amrita School of Dentistry, Kochi, 682041 Kerala IndiaR. B. ... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4328176 Fri, 07 Jan 2011 14:51:58 +0100 4328176 http://www.medworm.com/index.php?rid=4288068&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl8m542187716t0u6%2F Abstract  Aggressive osteoblastoma is a rare primary bone neoplasm with the potential for local invasion and recurrence. While the vertebrae or long bones are most commonly affected, few well-documented cases have been reported in the jaws. A 25-year-old man presented with a palatal mass of several months’ duration. He reported the lesion had undergone gradual enlargement and, while generally asymptomatic, had recently become increasingly painful. An incisional biopsy was interpreted as “osteoblastic neoplasm” most suggestive of osteoblastoma. However, final diagnosis was deferred until the resection specimen could be evaluated. Following partial maxillectomy, histopathologic examination revealed a proliferation of large epithelioid cells with eccentric nuclei and pro... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4288068 Wed, 22 Dec 2010 22:44:20 +0100 4288068 http://www.medworm.com/index.php?rid=4273766&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp612620773885632%2F Abstract  Although squamous cell carcinoma (SCC) variants account for less than 10% of all laryngeal SCCs, they have many unique biological, morphological, and clinical features. They are also easily confused with other tumor types. Recognition of them is critical for surgical pathologists as is the knowledge of what they mean for the patient. Three of the most common and important of these are basaloid, verrucous, and papillary SCC. These tumor types will be briefly reviewed with a focus on specific controversies, biological questions, and/or recent advancements in our understanding of them. Content Type Journal ArticleDOI 10.1007/s12105-010-0232-0Authors James S. Lewis, Department of Pathology and Immunology, Division of Anatomic and Molecular Pathology, Washington U... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4273766 Thu, 16 Dec 2010 18:27:27 +0100 4273766 http://www.medworm.com/index.php?rid=4269256&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp222415kn6g061v5%2F Abstract  The paradental cyst is commonly misinterpreted when associated with atypical clinical and radiographic characteristics, in turn causing diagnostic problems. For this reason, the study of the differential diagnosis of this lesion has become extremely important. In addition, the correlation of clinical, histologic, and radiographic findings are also of great value in obtaining accurate diagnoses. The minor variations in the clinical appearance of paradental cysts make it feasible to consider the two main groups of cysts separately: those associated with 1st and 2nd permanent molars of the mandible and those associated with the 3rd mandibular molar. Moreover, this distinction in localization may well dictate the necessary treatment. Bearing in mind the minor clinical... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4269256 Wed, 15 Dec 2010 16:05:50 +0100 4269256 http://www.medworm.com/index.php?rid=4239745&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp62m111532807205%2F Content Type Journal ArticleDOI 10.1007/s12105-010-0230-2Authors James T. Castle, Department Of Oral & Maxillofacial Pathology, Naval Postgraduate Dental School, NMMPT&E, 8901 Wisconsin Ave., Bethesda, MD 20889-5611, USA Journal Head and Neck PathologyOnline ISSN 1936-0568Print ISSN 1936-055X (Source: Head and Neck Pathology) Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4239745 Mon, 06 Dec 2010 15:09:07 +0100 4239745 http://www.medworm.com/index.php?rid=4239746&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff23730155702q4l3%2F Abstract  Myoepitheliomas are extremely rare benign neoplasms of salivary glands. They represent 1–1.5% of all salivary gland tumors. They occur, principally, in the parotid gland and infrequently in minor salivary glands. There are distinct histological and immunohistochemical characteristics of the tumor which aid in the diagnosis. Myoepithelioma of the palate is uncommon and only a limited number of cases has been reported in the English literature. Herein, a case of plasmacytoid type of myoepithelioma of the palate in an adult female is presented along with review of the literature. Content Type Journal ArticleDOI 10.1007/s12105-010-0231-1Authors Matina T. Zormpa, Department of Oral Medicine and Maxillofacial Pathology, School of Dentistry, Aristotle University o... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4239746 Mon, 06 Dec 2010 15:09:06 +0100 4239746 http://www.medworm.com/index.php?rid=4227354&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx4w3046p5v425827%2F We report herein a rare occurrence of tonsillar involvement by small lymphocytic lymphoma (SLL) incidentally detected during the workup for a cervical lymph node SCC metastasis of a 52-year-old non-smoker male. The microscopic human papillomavirus-positive SCC involving the tonsillar surface and crypts was obscured by SLL leading to the initial designation of ‘unknown primary’. The occult HNSCC are likely explained by small tumor size, quality and quantity of sampling, thoroughness of endoscopic, radiological and pathological assessment or a combination of the above. The coexistence of another tumor such as lymphoma has not yet been reported as a confounding factor in the workup for cervical SCC metastasis. Since oropharyngeal SCC can be very small and Waldeyer’s ring is a comm... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4227354 Tue, 30 Nov 2010 17:55:36 +0100 4227354 http://www.medworm.com/index.php?rid=4227355&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl439834t11m46714%2F We present two cases of benign smooth muscle proliferations in the tongue, provide a review, briefly discuss histogenesis and offer a clinico-pathological differential diagnosis. Content Type Journal ArticleDOI 10.1007/s12105-010-0229-8Authors M. R. Darling, DSB 4015, Division of Oral Pathology, Department of Pathology, Schulich School of Medicine and Dentistry, University of Western Ontario, 1151 Richmond Street, London, ON N6A 5C1, CanadaB. Wehrli, Department of Pathology, Schulich School of Medicine and Dentistry, University of Western Ontario, 1151 Richmond Street, London, ON N6A 5C1, CanadaE. Zeligman, Argyle Associates, 239 Argyle Avenue, Ottawa, ON K2P 1B8, CanadaJ. Smillie, Dental Practice, 323 Wilson Street E #201, Ancaster, ON L9G 4A8, CanadaT. Daley, DSB 4015, Division o... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4227355 Tue, 30 Nov 2010 08:17:19 +0100 4227355 http://www.medworm.com/index.php?rid=4206666&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fyx0510x86w76w484%2F Abstract  The Ewing’s family of tumors (EFT) are malignant neoplasms affecting children and young adults. Most cases arise in the long bones or the pelvis. Primary EFT of head and neck is uncommon and primary sinonasal EFT is even rarer. Previous studies have not focused on the sinonasal region specifically, and the published literature on sinonasal EFT consists of sporadic case reports. Fourteen cases of sinonasal EFT were available and had H&Es for review and immunohistochemical stains for CD99, S100, keratins, synaptophysin and desmin. FISH or RT-PCR was performed for EWSR1 abnormalities on 8 cases. The 14 identified patients included 5 males and 9 females, ranging from 7–70 years of age (mean 32.4 years). Tumors involved nasal cavity (5), sinuses (5) or bo... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4206666 Wed, 24 Nov 2010 20:23:57 +0100 4206666 http://www.medworm.com/index.php?rid=4201746&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fkn3152611175g823%2F Content Type Journal ArticleDOI 10.1007/s12105-010-0221-3Authors David Booth, School of Dentistry, University of Western Australia, 17 Monash Avenue, Nedlands, 6009 AustraliaJerry Bouquot, Department of Diagnostic Sciences, University of Texas Dental Branch at Houston, 6516 M.D. Anderson Blvd., Suite 3.094b, Houston, TX 77030, USA Journal Head and Neck PathologyOnline ISSN 1936-0568Print ISSN 1936-055X (Source: Head and Neck Pathology) Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4201746 Tue, 23 Nov 2010 18:17:11 +0100 4201746 http://www.medworm.com/index.php?rid=4193906&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fcl63g44831512735%2F We present a 45 year old female patient with a nasal carcinoma showing high-grade/anaplastic histomorphological features and with a distinct myoepithelial immunohistochemical phenotype including positivity for smooth muscle actin, p63, S100 protein with no sustentacular pattern, calponin, cytokeratin 14, vimentin and cytokeratins (AE1-3 and CK5/6). A minority (<5%) of the cells showed focal and variable immunoreactivity for EMA with no cuticular/canalicular pattern. Bcl-2, CD99, CD117 and CD56 were variously positive, but chromogranin and synaptophysin were negative. Weak to moderate nuclear p53 immunoreactivity was seen in 50% of tumor cells. Mib-1/Ki-67 showed an average proliferation of 60–70%. Fluorescent in situ hybridization revealed no EWS-gene translocation. In situ... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4193906 Sat, 20 Nov 2010 17:52:50 +0100 4193906 http://www.medworm.com/index.php?rid=4187775&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fbk05041024k14gj2%2F Abstract  A 13-month-old Japanese boy presented with painless swelling in a left mandible and cheek. Intraoral examination revealed swelling in the left mandible and hemorrhage of oral mucosa due to biting. CT images revealed a wide osteolytic lesion of the left mandible with floating teeth. Biopsy was carried out and histopathological diagnosis was discussed. Content Type Journal ArticleDOI 10.1007/s12105-010-0224-0Authors Takashi Muramatsu, Department of Pathology, Tokyo Dental College, 1-2-2, Masago, Mihama-ku, Chiba, 261-8502 JapanGillian L. Hall, Department of Histopathology, Manchester Royal Infirmary, Manchester, UKSadamitsu Hashimoto, Department of Pathology, Tokyo Dental College, 1-2-2, Masago, Mihama-ku, Chiba, 261-8502 JapanJun Miyauchi, Department of Patholog... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4187775 Thu, 18 Nov 2010 17:57:00 +0100 4187775 http://www.medworm.com/index.php?rid=4187777&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fjq2q32144475077w%2F Content Type Journal ArticleDOI 10.1007/s12105-010-0223-1Authors Hye-Jung Yoon, Department of Oral Pathology, School of Dentistry, Seoul National University, Seoul, South KoreaPrimali Jayasooriya, Department of Oral Pathology, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri LankaSeong-Doo Hong, Department of Oral Pathology, School of Dentistry, Seoul National University, Seoul, South KoreaJae-Il Lee, Department of Oral Pathology, School of Dentistry, Seoul National University, Seoul, South KoreaSam-Pyo Hong, Department of Oral Pathology, School of Dentistry, Seoul National University, Seoul, South Korea Journal Head and Neck PathologyOnline ISSN 1936-0568Print ISSN 1936-055X (Source: Head and Neck Pathology) Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4187777 Thu, 18 Nov 2010 17:56:59 +0100 4187777 http://www.medworm.com/index.php?rid=4187776&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj071852006261764%2F Content Type Journal ArticleDOI 10.1007/s12105-010-0225-zAuthors Patricia Devilliers, Department of Anatomic Pathology, University of Alabama at Birmingham, 3656 North Pavilion, 1802 6th Avenue South, Birmingham, AL 35249, USAAnna A. Talacko, Dorevitch Pathology, Melbourne, VIC AustraliaMichael J. Aldred, Dorevitch Pathology, Melbourne, VIC AustraliaJoel K. Cure, Department of Radiology, University of Alabama at Birmingham, Birmingham, AL USA Journal Head and Neck PathologyOnline ISSN 1936-0568Print ISSN 1936-055X (Source: Head and Neck Pathology) Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4187776 Thu, 18 Nov 2010 17:56:59 +0100 4187776 http://www.medworm.com/index.php?rid=4177025&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe525w21126087x88%2F Abstract  A case of gingival metastasis of adenocarcinoma of the colon is reported, the lesion being an early clinical indication of a primary malignant tumor. The diagnosis of metastatic lesion in the oral region is always challenging, both to clinician and to the pathologist, due to its rarity and complexity. In the present case, the clinical hypothesis was peripheral ossifying fibroma or pyogenic granuloma. Histologically, the biopsy tissue revealed a malignant neoplasm not connected to the mucosal surface. Immunohistochemically, the lesion was positive for 35ßH11 and cytokeratin 20 and focally positive for cytokeratin 7. Treatment involved excision of primary tumor and follow-up chemotherapy. The clinical, histological and immunohistochemical characteristics are discus... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4177025 Mon, 15 Nov 2010 18:08:19 +0100 4177025 http://www.medworm.com/index.php?rid=4177026&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx28q4161362q463l%2F Content Type Journal ArticleDOI 10.1007/s12105-010-0220-4Authors Camilla Kragelund, Department of Oral Medicine, Section of Oral Pathology, School of Dentistry, University of Copenhagen, 20, Norre Allé, 2200 Copenhagen N, DenmarkShabnum Meer, Division of Oral Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South AfricaLars Pallesen, Department of Oral and Maxillofacial Surgery, School of Dentistry, University of Copenhagen, Copenhagen, DenmarkJesper Reibel, Department of Oral Medicine, Section of Oral Pathology, School of Dentistry, University of Copenhagen, 20, Norre Allé, 2200 Copenhagen N, Denmark Journal Head and Neck PathologyOnline ISSN 1936-0568Print ISSN 1936-055X (Source: Head and Neck Pathology) Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4177026 Sat, 13 Nov 2010 06:47:52 +0100 4177026 http://www.medworm.com/index.php?rid=4177027&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F676803845044v324%2F Content Type Journal ArticleDOI 10.1007/s12105-010-0219-xAuthors Márcio Ajudarte Lopes, Áreas de Semiologia e Patologia Oral, Departamento de Diagnóstico Oral, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas (UNICAMP), Av. Limeira 901, CP52, Areião, Piracicaba, São Paulo 13414-903, BrazilHyun Sil Kim, Department of Oral Pathology, Oral Cancer Research Institute, College of Dentistry Yonsei University, Seoul, KoreaFernanda Viviane Mariano, Áreas de Semiologia e Patologia Oral, Departamento de Diagnóstico Oral, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas (UNICAMP), Av. Limeira 901, CP52, Areião, Piracicaba, São Paulo 13414-903, BrazilMarcelo Brum Corrêa, Department of Head and Neck Surgery, Oncology Center, Piracicaba, Bra... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4177027 Sat, 13 Nov 2010 06:47:51 +0100 4177027 http://www.medworm.com/index.php?rid=4141650&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn28118852360r715%2F Abstract  The aim of this study was to evaluate the biological profile of odontogenic epithelium by immunolabeling of epidermal growth factor receptor (EGFR), Ki-67 and survivin in keratocystic odontogenic tumors (KOT), dentigerous cysts (DC), and pericoronal follicles (PF). Immunohistochemical analysis was performed in 13 KOTs, 14 DCs and 9 PFs. Immunolabeling was analyzed in the basal and suprabasal layers of KOTs and DCs, and in the islands of odontogenic epithelium and/or reduced enamel epithelium of PFs. KOTs showed the highest proliferation rate among the three groups, mainly in suprabasal layers. EGFR immunolabeling was observed mainly in the cytoplasm in basal and suprabasal layers of KOTs and in the suprabasal layer of DCs. Immunolabeling in both membrane and cytop... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4141650 Thu, 04 Nov 2010 17:51:54 +0100 4141650 http://www.medworm.com/index.php?rid=4141649&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn4v2773064236200%2F Content Type Journal ArticleDOI 10.1007/s12105-010-0215-1Authors Sulen Sarioglu, Department of Pathology, Dokuz Eylul University Faculty of Medicine, 35340 Inciralti, Izmir, TurkeyFulya Cakalagaoglu, Department of Pathology, Yesilyurt Ataturk Research and Education Hospital, Izmir, TurkeySahande Elagoz, Department of Pathology, Cumhuriyet University Faculty of Medicine, Sivas, TurkeyUnsal Han, Department of Pathology, Ankara Diskapi Research and Education Hospital, Ankara, TurkeyDemet Etit, Department of Pathology, Yesilyurt Ataturk Research and Education Hospital, Izmir, TurkeySema Hucumenoglu, Department of Pathology, Ankara Diskapi Research and Education Hospital, Ankara, TurkeyIlgin Karaman, Department of Pathology, Dokuz Eylul University Faculty of Medicine, 35340 Inciralti, Izmir... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4141649 Thu, 04 Nov 2010 17:51:54 +0100 4141649 http://www.medworm.com/index.php?rid=4136860&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9k8361642812j466%2F Abstract  Seven expansile jaw lesions in patients ranging from 7 to 63 years are presented to illustrate diagnostic and management issues pertaining to cases ultimately proven to be gnathic osteosarcoma (GO). Six of the cases in our series were low-grade osteoblastic and one high-grade chondroblastic. None of our cases exhibited the characteristic “sunburst” radiopaque appearance described for GO. All of our cases displayed cortical expansion and one showed development of diastema. Two occurred in the maxilla and five in the mandible. Two of the patients with mandibular lesions presented initially with pain; all other patients were asymptomatic. Lack of pain resulted in a delay in diagnosis due to postponement of consultation or biopsy. Two cases underwent initial ... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4136860 Tue, 02 Nov 2010 17:34:52 +0100 4136860 http://www.medworm.com/index.php?rid=4136861&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg0u7m22273857406%2F This study reports three interesting cases of nodular submucosal lip lesions where foreign-body reactions of unknown origin were detected on hematoxylin and eosin (H&E) analysis. These materials were evaluated under polarized light microscopy, scanning electron microscopy and by energy dispersive X-ray analysis. The results revealed the following materials: an interdental toothbrush bristle, silica, and iron. Unusual mucosal foreign body reaction cases have been reported, but few publications used special techniques to identify the specific foreign material. Clinicians and pathologists might consider these techniques for identifying the precise origin of these foreign bodies. Content Type Journal ArticleDOI 10.1007/s12105-010-0217-zAuthors Adriele Ferreira Gouvêa, Department o... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4136861 Tue, 02 Nov 2010 17:34:49 +0100 4136861 http://www.medworm.com/index.php?rid=4112970&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq375876h056r18p2%2F In this report, we present a case of a female patient with a sphenoid sinus mass. Clinically, the patient had progressively decreasing vision and headache. Magnetic resonance imaging (MRI) and computerized tomographic (CT) scan showed an infiltrating tumor mass involving the sphenoid sinus and the sella with compression of the optic nerve. Pathologic examination revealed an invasive basaloid epithelial neoplasm that was arranged in lobules, nests and cords. The tumor also showed palisading of peripheral cells, focal abrupt squamous differentiation and in situ carcinoma in the surface mucosa. In the immunohistochemical studies, this tumor revealed a strongly positive nuclear staining for p63. The morphologic and ancillary studies indicated a BSCC. To the best of our knowledge, this is... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4112970 Sat, 23 Oct 2010 15:49:11 +0100 4112970 http://www.medworm.com/index.php?rid=4092329&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9x15036228282118%2F We report a case of a 15-year-old boy who developed progressive proptosis and hypertelorism and was found to have a mid-face and skull base tumor, initially diagnosed as psammomatoid meningioma. The tumor recurred and the resected specimen revealed a unique OF having trabecular and psammomatoid features. The clinical, radiographic, histopathologic findings and differential diagnoses of the case are presented. Content Type Journal ArticleDOI 10.1007/s12105-010-0212-4Authors Olga L. Bohn, Department of Pathology, MetroHealth Medical Center-Case Western Reserve University, Cleveland, OH 44109, USAJohn R. Kalmar, Section of Oral and Maxillofacial Pathology, College of Dentistry, The Ohio State University Medical Center, Columbus, OH 43210, USACarl M. Allen, Section of Oral and Maxill... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4092329 Sat, 16 Oct 2010 08:54:35 +0100 4092329 http://www.medworm.com/index.php?rid=4092328&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr156601t73v60344%2F Abstract  The peripheral calcifying odontogenic cyst (PCOC) accounts for less than 25% of the cases of calcifying odontogenic cysts and most commonly appears as a nodule on the gingiva. This paper aims to present both a case report of a PCOC located in the left vestibular maxilla as well as a review of the English-language literature. An 11-year-old female patient presented a swelling in the vestibular region of teeth 12 and 13. Periapical and panoramic radiographs demonstrated irregular calcification. Surgical excision was performed. Microscopic examination showed an odontogenic cystic lesion lined by ameloblastoma-like epithelium, containing numerous ghost cells. Areas of calcification associated with ghost cells could also be observed. The patient was diagnosed with PCOC... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4092328 Sat, 16 Oct 2010 08:54:35 +0100 4092328 http://www.medworm.com/index.php?rid=4042739&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6lg05475811234q2%2F Abstract  Angiosarcoma of the oral cavity is extremely rare. A 54-year-old woman consulted to our hospital because of mass of the left cheek next to the mandible. MRI showed a 1 cm tumor. Enucleation of the tumor was performed. Grossly, the tumor was not encapsulated and had a central cavity. Histologically, the tumor consisted of spindle and polygonal cells with hyperchromatic nuclei with nucleoli. Intracytoplasmic vacuoles and mitotic figure were scattered. Vasoformative channels were present in some areas. Lymphoid follicles were scattered in the tumor. The tumor was invasive into the surrounding tissue, and lymphovascular permeation was noted. The surgical margins were positive. Immunohistochemically, the tumor cells were positive for factor VIII-related antigen, C... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4042739 Tue, 05 Oct 2010 18:09:50 +0100 4042739 http://www.medworm.com/index.php?rid=4024603&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv66314x626ju3r3q%2F Abstract  K19 is an intermediate filament protein that has been investigated in oral squamous cell carcinoma (OSCC), but that has not been correlated with the amount of keratin produced within well-differentiated OSCC grade. The aim of the present study was to objectively analyze K19 immunoexpression in OSCC and to validate the utility of K19 in differentiation among grades of oral epithelial dysplasia (OED). Formalin-fixed tissues of 36 primary OSCC (22 well, 10 moderately, 4 poorly differentiated), 43 OED (23 mild, 8 moderate, 12 severe), and 11 normal oral epithelium (NOE) were included. K19 was immunostained using HRP-DAB method. The percentage of K19-positive area was found using color deconvolution program in ImageJ® image analysis system (public domain software, Nati... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=4024603 Thu, 30 Sep 2010 08:00:48 +0100 4024603 http://www.medworm.com/index.php?rid=3996264&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr3458632h43x034p%2F Abstract  Although extremely rare, the presence of ectopic thyroid tissue in the submandibular region should be considered in the differential diagnosis of tissue masses in the cervical region. Diagnosis is confirmed by fine-needle aspiration biopsy and exclusion of malignancy should be confirmed by histopathologic analysis of the lesion. In general, surgery is the treatment of choice. A rare case of ectopic thyroid in the right submandibular region is reported; it was diagnosed after total thyroidectomy and successfully treated through surgery. Content Type Journal ArticleDOI 10.1007/s12105-010-0209-zAuthors Joseli Assem Bersaneti, Department of Surgery, School of Medical Sciences, Universidade de Marília (UNIMAR), Av. Rio Branco, 1132–Cj. 41, Marília, São Paulo ... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=3996264 Tue, 21 Sep 2010 04:11:00 +0100 3996264 http://www.medworm.com/index.php?rid=3996265&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq12248505281kkg2%2F Abstract  In this series, laryngeal preneoplastic lesions were evaluated by the classifications of the World Health Organization (WHOC), Ljubljana (LC) and squamous intraepithelial neoplasia (SINC) by multiple observers. The inter-observer agreement (IA) by WHOC for laryngeal lesions had been previously evaluated, but to the best of our knowledge, there are no data for LC and SINC. H&E stained slides from 42 laryngeal biopsies were evaluated by fourteen participants according to WHOC and LC, and SINC was additionally applied by 6. The results were analyzed statistically. The diagnoses which were favored by most participants for each case, according to WHOC, were as follows: squamous cell hyperplasia (n = 5; 12%), mild dysplasia (n = 11; 26.2%), moderate d... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=3996265 Tue, 21 Sep 2010 04:10:57 +0100 3996265 http://www.medworm.com/index.php?rid=3918107&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fjm6w28732r067775%2F We report a case of LMS of the nasal sinus area in a 35-year-old African American male with a history of non-hereditary unilateral RB and radiation therapy. To the best of our knowledge, this is the first reported case of sinonasal LMS arising in a patient with a history of non-hereditary unilateral RB. The clinical history, radiology, and pathology are presented along with a brief discussion of the literature. Content Type Journal ArticleDOI 10.1007/s12105-010-0207-1Authors Sarah G. Fitzpatrick, Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry, 1600 SW Archer Drive Rm D8-6, Gainesville, FL 32610, USABradford A. Woodworth, Department of Surgery/Division of Otolaryngology, University of Alabama, Birmingham, AL USACarmela Monteiro... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=3918107 Sat, 28 Aug 2010 17:06:30 +0100 3918107 http://www.medworm.com/index.php?rid=3905709&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv8015r1346044146%2F Abstract  One case of an expansile mass involving the roots of a mandibular left first molar in a nine year old male is presented. The lesion has features of a cementoblastoma (CB), osteoblastoma (OB), and osteosarcoma (OS) both radiographically and histologically. Radiographically, a “sunburst” appearance is present. Histologically, the lesional tissue is intimately involved with the root, not the periosteum. The clinical, radiographic, and histopathologic characteristics of CB, OB, and OS are discussed as well as the difficulties associated with distinguishing between these lesions in the gnathic region. Content Type Journal ArticleDOI 10.1007/s12105-010-0205-3Authors Elizabeth Bilodeau, Department of Diagnostic Sciences, University of Pittsburgh School of Dental... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=3905709 Wed, 25 Aug 2010 06:14:26 +0100 3905709 http://www.medworm.com/index.php?rid=3897856&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2822212831mhu6q4%2F We report the case of a 28-year-old male diagnosed with a B lymphoblastic lymphoma (CD20−; CD79a+; CD3−; CD10+; PAX5+, CyclinD1−; TdT+) of the nasopharynx extending to the deep and superficial structures of the right hemiface, to the skull base with an intracranial component and a small but detectable bone marrow involvement, who was started on chemotherapy with a complete response. To the best of our knowledge, this is the first case of a primary nasopharynx B-LBL in an adult patient with such aggressive regional spread to be reported in the literature. Content Type Journal ArticleDOI 10.1007/s12105-010-0206-2Authors Rodrigo Lopes da Silva, Serviço de Hematologia, Hospital Santo António dos Capuchos, Alameda Santo António dos Capuchos, 1169-050 Lisbon, PortugalTeresa F... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=3897856 Sat, 21 Aug 2010 16:45:39 +0100 3897856 http://www.medworm.com/index.php?rid=3897857&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh247594075681334%2F This study evaluates their clinicopathologic characteristics in head and neck mucosal sites and the problems in distinguishing them from other spindle cell tumors. A total of 103 cases with a confirmed diagnosis of sarcomatoid carcinoma accessioned in the pathology department of a tertiary referral cancer centre over a period of 7 years (2004–2010) were studied. An algorithm used for their diagnosis is presented. Ages of the patients were 22–90 years (median 53 years), and male:female ratio was 3.7:1. Site distribution was oral cavity (n = 65, 63.1%), larynx (18, 17.5%), oropharynx/hypopharynx (12, 10.7%), maxilla (6, 5.8%) and metastatic nodes (2, 1.9%). A large number of patients (95%) presented with a mass lesion of less than 1 year duration. Histopathologic... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=3897857 Sat, 21 Aug 2010 16:45:38 +0100 3897857 http://www.medworm.com/index.php?rid=3883567&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa45q57xr84v88klw%2F Abstract  Paraneoplastic syndromes associated with head and neck cancer are rare and have been reported under dermatological, endocrine, hematological, neurological and rheumatological disorders. Bazex syndrome is an intriguing paraneoplasia that can be associated with head and neck squamous cell carcinomas. A range of symmetrical dermatological manifestations, with a clear predilection to extremities, that encompasses erythematous squamous plaques, skin scaling and nail dystrophy can provide a psoriasiform pattern in Bazex syndrome. In addition to these tricky clinical features, the rarity of the disease and the lack of understanding on Bazex syndrome generally make such cases to be mismanaged as psoriasis or lichen planus, causing an important delay in the diagnosis of th... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=3883567 Wed, 18 Aug 2010 17:44:33 +0100 3883567 http://www.medworm.com/index.php?rid=3866323&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq87811q182324130%2F Abstract  A 24 year male presented with a radiolucent lesion associated with the right maxillary canine. Histologic examination of the biopsy material resulted in a diagnosis of squamous odontogenic tumor a rare, benign epithelial odontogenic neoplasm. The clinical, radiographic and morphologic features of the squamous odontogenic tumor are discussed. Content Type Journal ArticleDOI 10.1007/s12105-010-0198-yAuthors Bradley E. Jones, Joint POW-MIA Accounting Command, Hickam AFB, HI USAAaron P. Sarathy, Oral and Maxillofacial Surgery, Naval Hospital, Beaufort, SC USAM. Belinda Ramos, Laboratory Department, Naval Hospital, Jacksonville, FL USARobert D. Foss, Department of Oral and Maxillofacial Pathology, Armed Forces Institute of Pathology, Room 3055, 6825 16th Street... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=3866323 Mon, 09 Aug 2010 19:40:39 +0100 3866323 http://www.medworm.com/index.php?rid=3866324&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg8n3602838j52851%2F We report a 53-year-old male patient who was diagnosed with a collision tumor of laryngeal melanoma and invasive SCC. Multiple Th17 pathway related genes including CTLA-4, IL-17A-F, PLZF, FoxP3, RorγT, CD27, and CD70 were analyzed by reverse transcriptase-polymerase chain reaction (Rt–PCR) in this case. Both IL-17A and CD70 genes were detected in this case of collision tumor. The results may define useful biomarkers for early diagnosis of mucosal melanoma and open an immunotherapeutic field for clinical management with the potential benefit from the immunomodulators that enhance both genes. Content Type Journal ArticleDOI 10.1007/s12105-010-0200-8Authors Sasis Sirikanjanapong, Department of Pathology, New York University School of Medicine, 550 First Avenue, TCH-461, New Yor... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=3866324 Mon, 09 Aug 2010 19:40:38 +0100 3866324 http://www.medworm.com/index.php?rid=3832623&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx817l641255k7vq8%2F We present a patient (male 54 years) with a history of renal transplant who 14 years post transplantation developed a symptomatic (stridor) laryngeal Epstein Barr virus (EBV)—associated smooth muscle tumor (EBV-SMT) in the absence of concomitant disease elsewhere. Nine years post transplantation the patient developed a subcutaneous EBV-SMT tumor located on the calf. The laryngeal tumor displayed low-grade nuclear atypia and was infiltrating into the surrounding soft tissue, focally ulcerating through the overlying epithelium. Histologic features included: neoplastic cells with myoid differentiation, a component of primitive appearing small mesenchymal cells with hyperchromatic nuclei, mitotic activity, intralesional small to medium sized blood vessels and T-lymphocytes. B... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=3832623 Fri, 06 Aug 2010 07:14:35 +0100 3832623 http://www.medworm.com/index.php?rid=3811041&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft62l5884u8728224%2F Content Type Journal ArticleCategory 64TH ANNUAL MEETING OF THE AMERICAN ACADEMY OF ORAL AND MAXILLOFACIAL PATHOLOGYDOI 10.1007/s12105-010-0195-1Authors Kristin K. McNamara, The Ohio State University 305 West 12th Ave. Columbus OH 43210 USAMikelle L. Kernig, USAF, Wright Patterson AFB Dayton OH USAKelly S. Kreuter, The Ohio State University 305 West 12th Ave. Columbus OH 43210 USAJohn R. Kalmar, The Ohio State University 305 West 12th Ave. Columbus OH 43210 USACarl M. Allen, The Ohio State University 305 West 12th Ave. Columbus OH 43210 USA Journal Head and Neck PathologyOnline ISSN 1936-0568Print ISSN 1936-055X (Source: Head and Neck Pathology) Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=3811041 Fri, 30 Jul 2010 17:25:16 +0100 3811041 http://www.medworm.com/index.php?rid=3811040&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb1178x323n736n08%2F Content Type Journal ArticleCategory 64TH ANNUAL MEETING OF THE AMERICAN ACADEMY OF ORAL AND MAXILLOFACIAL PATHOLOGYDOI 10.1007/s12105-010-0192-4Authors Nasser Said-Al-Naief, University of the Pacific OMFP Laboratory and Clinical Oral Pathology/Oral Medicine, Room 412, Department of Pathology and Medicine 2155 Webster Street San Francisco CA 94115-2333 USAMolly S. Rosebush, University of Tennessee College of Dentistry Department of Biologic and Diagnostic Sciences Memphis TN USADenis Lynch, Marquette University School of Dentistry, Academic Affairs Milwaukee WI USA Journal Head and Neck PathologyOnline ISSN 1936-0568Print ISSN 1936-055X (Source: Head and Neck Pathology) Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=3811040 Fri, 30 Jul 2010 17:25:16 +0100 3811040 http://www.medworm.com/index.php?rid=3811043&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Far3332u1m32p3774%2F Content Type Journal ArticleCategory 64TH ANNUAL MEETING OF THE AMERICAN ACADEMY OF ORAL AND MAXILLOFACIAL PATHOLOGYDOI 10.1007/s12105-010-0196-0Authors Joseph C. Whitt, University of Missouri Kansas City Oral and Maxillofacial Pathology, School of Dentistry Kansas City MO USABrian S. Shumway, University of Louisville School of Dentistry Department of Surgical and Hospital Dentistry Louisville KY USAElliot A. Magidson, Wichita Clinic Pathology Department Wichita KS USARoy E. Cole, Oral and Maxillofacial Surgery Private Practice Wichita KS USA Journal Head and Neck PathologyOnline ISSN 1936-0568Print ISSN 1936-055X (Source: Head and Neck Pathology) Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=3811043 Fri, 30 Jul 2010 17:25:15 +0100 3811043 http://www.medworm.com/index.php?rid=3811042&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fjm3266147243l714%2F Abstract  Patients affected by autoimmune diseases (rheumatoid arthritis, psoriasis, dermatomyositis) who are treated with methotrexate (MTX) sometimes develop lymphoproliferative disorders (LPDs). In approximately 40% of reported cases, the affected sites have been extranodal, and have included the gastrointestinal tract, skin, lung, kidney, and soft tissues. However, MTX-associated LPD (MTX-LPD) is extremely rare in the oral cavity. Here we report a 69-year-old Japanese woman with rheumatoid arthritis (RA) who developed MTX-LPD resembling Hodgkin’s disease—so-called “Hodgkin-like lesion”—in the left upper jaw. Histopathologically, large atypical lymphoid cells including Hodgkin or Reed-Sternberg-like cells were found to have infiltrated into granulation tissue i... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=3811042 Fri, 30 Jul 2010 17:25:15 +0100 3811042 http://www.medworm.com/index.php?rid=3811044&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr72387n5554t6g52%2F Content Type Journal ArticleCategory 64TH ANNUAL MEETING OF THE AMERICAN ACADEMY OF ORAL AND MAXILLOFACIAL PATHOLOGYDOI 10.1007/s12105-010-0199-xAuthors James M. Hall, Tufts University School of Dental Medicine Department of Oral and Maxillofacial Pathology 1 Kneeland St. Boston MA 02111 USAKevin R. Torske, Naval Postgraduate Dental School Department of Oral and Maxillofacial Pathology Bethesda MD USAMichael A. Kahn, Tufts University School of Dental Medicine Department of Oral and Maxillofacial Pathology 1 Kneeland St. Boston MA 02111 USAAdele A. Moreland, Lahey Clinic Medical Center Department of Dermatology Burlington MA USASamuel L. Moschella, Lahey Clinic Medical Center Department of Dermatology Burlington MA USA Journal Head and Neck PathologyOnline ISSN 1936-0568Print ISS... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=3811044 Fri, 30 Jul 2010 17:25:14 +0100 3811044 http://www.medworm.com/index.php?rid=3811045&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F944j1p1754210n12%2F Content Type Journal ArticleCategory 64TH ANNUAL MEETING OF THE AMERICAN ACADEMY OF ORAL AND MAXILLOFACIAL PATHOLOGYDOI 10.1007/s12105-010-0194-2Authors Craig B. Fowler, 59 Dental Training Squadron/SGDTM Oral and Maxillofacial Pathology 2200 Bergquist Drive Suite 1, Lackland AFB San Antonio TX 78236-5300 USANisha J. D’Silva, University of Michigan School of Dentistry Department of Periodontics and Oral Medicine 1011 North University Avenue, Room G018 Ann Arbor MI 48109-1078 USA Journal Head and Neck PathologyOnline ISSN 1936-0568Print ISSN 1936-055X (Source: Head and Neck Pathology) Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=3811045 Fri, 30 Jul 2010 17:25:13 +0100 3811045 http://www.medworm.com/index.php?rid=3792624&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc0r6314071672164%2F Content Type Journal ArticleCategory Sine qua none Radiology-PathologyDOI 10.1007/s12105-010-0197-zAuthors Ximena Zornosa, Clayton State University Department of Dental Hygiene, College of Health 2000 Clayton State Boulevard Morrow GA 30260 USASusan Müller, Emory University School of Medicine Department of Pathology and Laboratory Medicine, Department of Otolaryngology Head and Neck Surgery, Winship Cancer Institute 1365 Clifton Rd, NE, Room A2134 Atlanta GA 30322 USA Journal Head and Neck PathologyOnline ISSN 1936-0568Print ISSN 1936-055X (Source: Head and Neck Pathology) Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=3792624 Sat, 24 Jul 2010 13:52:12 +0100 3792624 http://www.medworm.com/index.php?rid=3792623&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Flm53k4106q8q7p8w%2F Content Type Journal ArticleCategory 64TH ANNUAL MEETING OF THE AMERICAN ACADEMY OF ORAL AND MAXILLOFACIAL PATHOLOGYDOI 10.1007/s12105-010-0193-3Authors Ilana Kaplan, Tel-Aviv Sourasky Medical Center Institute of Pathology 6 Weitzman St Tel Aviv IsraelSonal S. Shah, New York University Department of Oral and Maxillofacial Pathology, Radiology, and Medicine, College of Dentistry New York NY USAZoe Nicolaou-Ioannou, Private Oral and Maxillofacial Surgery Limassol CyprusDan M. Fliss, Tel-Aviv Sourasky Medical Center Department of Otolaryngology, Head and Neck Surgery Tel Aviv Israel Journal Head and Neck PathologyOnline ISSN 1936-0568Print ISSN 1936-055X (Source: Head and Neck Pathology) Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=3792623 Sat, 24 Jul 2010 13:52:12 +0100 3792623 http://www.medworm.com/index.php?rid=3756158&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv811528100736136%2F We report an example of intraosseous mucoepidermoid carcinoma with positive TORC1/MAML2 gene fusion transcript and discuss the clinical implications. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s12105-010-0191-5Authors Haseeb Ahmed Khan, Shaukat Khanum Memorial Cancer Hospital & Research Centre Department of Pathology Johar Town, Lahore PakistanAsif Loya, Shaukat Khanum Memorial Cancer Hospital & Research Centre Department of Pathology Johar Town, Lahore PakistanRafay Azhar, Shaukat Khanum Memorial Cancer Hospital & Research Centre Department of Pathology Johar Town, Lahore PakistanNasir Ud Din, Aga Khan University Hospital Department of Pathology Karachi PakistanDiana Bell, The University of Texas M.D. Anderson Cancer Center Department of Pathology Houston TX USA ... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=3756158 Tue, 13 Jul 2010 15:39:13 +0100 3756158 http://www.medworm.com/index.php?rid=3756159&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl323x7p8h2400j86%2F We describe the case of a 31-year-old male who presented with biphasic SS with poorly differentiated areas (clinical stage IIA) in a palatine tonsil, an extremely rare site of SS. Molecular analyses revealed typical t(X;18) translocation of the SYT gene and a SYT/SSX1 fusion type. The tumor was surgically resected with free margins. Adjuvant radiotherapy or chemotherapy was not considered indicated. To date, the patient has remained free of tumor for 4 years after surgery. Literature review reveals that primary tonsillar HNSS has previously been documented only in three patients. In all of these patients the tumor was histologically biphasic; however only one published case and the case presented here showed areas of poor differentiation. We discuss the relevance of the present... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=3756159 Tue, 13 Jul 2010 15:39:04 +0100 3756159 http://www.medworm.com/index.php?rid=3735516&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff2p305vkjw582512%2F This report describes a case of odontogenic myxoma producing diffusely dispersed calcified products in a pattern reminiscent of a fibro-osseous lesion of the jaw. Differential diagnoses for myxoid lesions of the jaws also are discussed. This paper highlights how an odontogenic myxoma can produce a large amount of calcified products to mimic a fibro-osseous process. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s12105-010-0189-zAuthors Yi-Ling Lin, University of California at Los Angeles, School of Dentistry Department of Diagnostic and Surgical Sciences 10833 Le Conte Ave. Los Angeles CA 90095 USAJohn R. Basile, University of Maryland Dental School Department of Oncology and Diagnostic Sciences 650 W. Baltimore St., 7-North Baltimore MD 21201 USA Journal Hea... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=3735516 Tue, 06 Jul 2010 17:07:26 +0100 3735516 http://www.medworm.com/index.php?rid=3716521&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fdx047246481ml332%2F Abstract  Laryngeal atypical carcinoids (AC/moderately-differentiated neuroendocrine carcinoma) are associated with moderately aggressive clinical behavior; however, a subset of tumors classified as AC have much greater aggressive potential. These tumors fulfill the proposed diagnostic criteria for pulmonary large cell neuroendocrine carcinoma, albeit in the larynx. In the current WHO classification, laryngeal large cell neuroendocrine carcinomas (LCNEC) are classified as variants of AC, whereas pulmonary LCNEC are classified as poorly-differentiated neuroendocrine carcinomas. Reported outcomes for pulmonary tumors support the separate classification of LCNEC. Five and ten year survival rates for pulmonary AC are 61–73, and 35–59%, respectively, while the 5-year survival... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=3716521 Tue, 29 Jun 2010 16:34:52 +0100 3716521 http://www.medworm.com/index.php?rid=3689256&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F97624750v347762j%2F Abstract  Sialolipoma is a rare benign neoplasm characterized by a well-circumscribed mass composed of neoplastic mature adipose tissue and non-neoplastic salivary gland elements. A 72-year-old woman presented with a painless swelling located in the hard palate, which had been identified 15 days earlier. Microscopically, the tumor was well-circumscribed consisting of lobular proliferation of the lipomatous tissue with thin fibrous tissue septa containing clustered salivary gland elements. Both the glandular and adipose components were found in almost equal proportion. No atypia in the adipose tissue was observed. The definitive diagnosis was sialolipoma. The patient showed no signs of recurrence 8 months after surgical excision. Including the present case, 35 case... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=3689256 Sun, 20 Jun 2010 23:09:33 +0100 3689256 http://www.medworm.com/index.php?rid=3669154&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ffg11358737536176%2F Abstract  For many years, gingival tumors of what appear to be peripherally located intraosseous ameloblastoma (IA) arising from the alveolar bone surface have often been confused with peripheral ameloblastoma (PA) causing resorption of the underlying bone. We analyzed a series of five cases of ameloblastoma that demonstrated a combined PA and IA architecture. The tumor commonly involved the anterior-premolar area, mostly in the maxilla and mainly in middle-aged men. The clinical presentation was an exophytic gingival mass inferior to which was a small bone defect. The predominant extraosseous component showed a papillary gross surface, reflecting the histologic proof of fusion between the submucosal tumor and the surface epithelium. In addition to the PA-like growth patter... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=3669154 Mon, 14 Jun 2010 13:52:45 +0100 3669154 http://www.medworm.com/index.php?rid=3654469&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7789851786263251%2F Abstract  Eosinophilc angiocentric fibrosis is a rare fibrosing vasculitis of unknown etiology that is progressive and potentially disfiguring. It has a predilection for the upper airways presenting most commonly as an obstructing mass lesion that is diagnosed histologically. Thus far, it has been nonfatal in the more than 40 reported cases; however, subglottic and ocular involvement has resulted in significant morbidity in several patients. Treatment has been challenging with persistent disease in most cases. The current case is a prototypical presentation with a limited nasal septal lesion providing the opportunity to discuss clinically relevant issues and increase awareness. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s12105-010-0185-3Authors Jumin ... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=3654469 Wed, 09 Jun 2010 09:24:58 +0100 3654469 http://www.medworm.com/index.php?rid=3654470&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn27109u27852n376%2F Abstract  A case of compound odontomas of the anterior maxilla is discussed. Multiple tooth like structures were discovered upon surgical excision. Content Type Journal ArticleCategory Sine qua none Radiology-PathologyDOI 10.1007/s12105-010-0186-2Authors Brenda L. Nelson, Naval Medical Center San Diego Department of Anatomic Pathology 34800 Bob Wilson Drive San Diego CA 92134-5000 USALester D. R. Thompson, Naval Medical Center San Diego Department of Anatomic Pathology 34800 Bob Wilson Drive San Diego CA 92134-5000 USA Journal Head and Neck PathologyOnline ISSN 1936-0568Print ISSN 1936-055X (Source: Head and Neck Pathology) Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=3654470 Wed, 09 Jun 2010 09:24:57 +0100 3654470 http://www.medworm.com/index.php?rid=3654471&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fwm571078m1830873%2F In conclusion, our analysis shows that primary oral DLBCL predominantly belongs to the non-GCB subgroup, which tends to exhibit a poorer prognosis. These findings could allow pathologists to provide a more accurate insight into the potential aggressive behavior and poorer prognosis of these lymphomas. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12105-010-0184-4Authors Indraneel Bhattacharyya, University of Florida College of Dentistry Department of Oral and Maxillofacial Diagnostic Sciences PO Box 100414 Gainesville FL 32610 USAHardeep K. Chehal, Creighton University School of Dentistry Department of General Dentistry Omaha NE USADonald M. Cohen, University of Florida College of Dentistry Department of Oral and Maxillofacial Diagnostic Sciences PO Box 100414 Ga... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=3654471 Wed, 09 Jun 2010 09:24:56 +0100 3654471 http://www.medworm.com/index.php?rid=3611382&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp18j5h3k4706071n%2F In this report, we describe the first gingival case of oral neurothekeoma with histopathologic and immunohistochemical characteristics. The patient, a 32 year old female presented with a slowly growing gingival mass diagnosed clinically as an epulis. The lesion was surgically excised. Histopathologically, the lesion presented as a submucosal multinodular mass composed of spindle and stellate-shaped cells with a myxoid background. Immunohistochemically, the tumor cells were sporadically positive for S-100 and NSE and negative for GFAP, EMA, SMA, CD68 and HMB45. The immunoprofile of this lesion confirmed a Schwann cell origin. The lesion was followed up for 10 months with no reports of recurrence. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s12105-010-018... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=3611382 Tue, 25 May 2010 16:52:09 +0100 3611382 http://www.medworm.com/index.php?rid=3565519&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp23r14176664q336%2F Content Type Journal ArticleCategory Sine qua none Radiology-PathologyDOI 10.1007/s12105-010-0181-7Authors S. Marc Stokes, Naval Postgraduate Dental School, NMMPT&E Department of Oral & Maxillofacial Pathology 8901 Wisconsin Ave. Bethesda MD 20889-5611 USAJames T. Castle, Naval Postgraduate Dental School, NMMPT&E Department of Oral & Maxillofacial Pathology 8901 Wisconsin Ave. Bethesda MD 20889-5611 USA Journal Head and Neck PathologyOnline ISSN 1936-0568Print ISSN 1936-055X (Source: Head and Neck Pathology) Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=3565519 Thu, 13 May 2010 08:59:06 +0100 3565519 http://www.medworm.com/index.php?rid=3565520&cid=s_35965_32_f&fid=35965&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn05u813850w31215%2F Abstract  Oral manifestations of tuberculosis are quite rare with an incidence rate of 1.4%. The tongue is the most common site of oral tuberculosis having varied presentations. Lingual tuberculosis is a diagnostic dilemma because of its rarity, particularly in immunocompetent patients. We are reporting a rare case of primary tuberculosis of the tongue in a 38 year old male diagnosed on fine needle aspiration cytology. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s12105-010-0180-8Authors Sanjay Kumar, 4/9J, Medical Enclave, PGIMS Rohtak 124001 Haryana IndiaRajeev Sen, PGIMS Department of Pathology Rohtak 124001 Haryana IndiaAnju Rawal, PGIMS Department of Pathology Rohtak 124001 Haryana IndiaRanbir Singh Dahiya, PGIMS Department of Surgery Rohtak 124... Head and Neck Pathology journals http://www.medworm.com/rss/comments.php?id=3565520 Thu, 13 May 2010 08:59:05 +0100 3565520