MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Helicobacter' source. Fri, 19 Mar 2010 15:27:10 +0100 http://www.medworm.com/index.php?rid=3324336&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00743.x Conclusion: Both in vitro and in vivo studies provide evidence that probiotics may represent a novel approach to the management of H. pylori infection. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3324336 Wed, 03 Mar 2010 14:26:27 +0100 3324336 http://www.medworm.com/index.php?rid=3324346&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00742.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3324346 Wed, 03 Mar 2010 00:00:00 +0100 3324346 http://www.medworm.com/index.php?rid=3324345&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00741.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3324345 Wed, 03 Mar 2010 00:00:00 +0100 3324345 http://www.medworm.com/index.php?rid=3324344&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00739.x Conclusion: Two weeks of treatment with ofloxacin, azithromycin, omeprazole, and bismuth is an effective and safe regimen for H. pylori eradication as second-line therapy. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3324344 Wed, 03 Mar 2010 00:00:00 +0100 3324344 http://www.medworm.com/index.php?rid=3324343&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00748.x Conclusions: Ten-day sequential therapy is found to effectively eradicate H. pylori infection as first-line treatment in Korea. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3324343 Wed, 03 Mar 2010 00:00:00 +0100 3324343 http://www.medworm.com/index.php?rid=3324342&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00747.x Conclusion: Extended duration of amoxicillin treatment during the entire tetracycline containing sequential therapy period did not improve the H. pylori eradication rate. As a consequence, sequential therapy using 5-day amoxicillin is an acceptable first-line therapy option for the eradication of H. pylori in Turkey. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3324342 Wed, 03 Mar 2010 00:00:00 +0100 3324342 http://www.medworm.com/index.php?rid=3324341&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00744.x Conclusion: The genus Helicobacter should accordingly be viewed as a collection of hundreds of organisms that have colonized most tetrapod taxa and have the potential to expand into new hosts as contact among animals and between animals and people increases. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3324341 Wed, 03 Mar 2010 00:00:00 +0100 3324341 http://www.medworm.com/index.php?rid=3324340&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00745.x Discussion: We propose that the genetic variability of hsdS genes in a bacterial population will give rise to new specificities of these enzymes, which might lead to adaptation to an ever-changing gastric environment. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3324340 Wed, 03 Mar 2010 00:00:00 +0100 3324340 http://www.medworm.com/index.php?rid=3324339&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00746.x Conclusions: Most H. pylori infections are acquired at preschool age and transient infection beyond this age is uncommon in this population. Helicobacter pylori-infected siblings are the major reservoir of H. pylori in early and late childhood demonstrating sustained intra-familial transmission of H. pylori. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3324339 Wed, 03 Mar 2010 00:00:00 +0100 3324339 http://www.medworm.com/index.php?rid=3324338&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00749.x Conclusion: These findings show, for the first time, the ability of HhCDT to induce apoptosis via the mitochondrial pathway. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3324338 Wed, 03 Mar 2010 00:00:00 +0100 3324338 http://www.medworm.com/index.php?rid=3324337&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00740.x Conclusions: There is a high prevalence of asymptomatic H. pylori infection in recently resettled African refugee children. Gastrointestinal symptoms were not predictive of H. pylori nor of helminth infections. Serum cytokines, particularly IL-5, IL-10, and TNF[alpha], were significantly elevated in children with malaria and helminth infections but not in those with H. pylori infection. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3324337 Wed, 03 Mar 2010 00:00:00 +0100 3324337 http://www.medworm.com/index.php?rid=3165263&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00732.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3165263 Wed, 13 Jan 2010 00:00:00 +0100 3165263 http://www.medworm.com/index.php?rid=3165262&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00733.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3165262 Wed, 13 Jan 2010 00:00:00 +0100 3165262 http://www.medworm.com/index.php?rid=3165261&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00736.x Conclusions: K. heterogenica colonizes the stomach of Mongolian gerbils in exactly the same regions as gastric Helicobacter species. The uncontrolled presence of this yeast in the gerbil stomach can lead to an overestimation of the inflammation caused by Helicobacter in this animal model. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3165261 Wed, 13 Jan 2010 00:00:00 +0100 3165261 http://www.medworm.com/index.php?rid=3165260&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00730.x Conclusions: Helicobacter bizzozeronii remains the only "H. heilmannii" species isolated from human gastric mucosa although it has been an infrequent observation among "H. heilmannii"-infected patients in PCR-based screening studies. The relevance of H. bizzozeronii and other potentially zoonotic gastric Helicobacter spp. in human disease remains to be determined. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3165260 Wed, 13 Jan 2010 00:00:00 +0100 3165260 http://www.medworm.com/index.php?rid=3165259&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00731.x Conclusions: Our data demonstrated that altered redox equilibrium may be associated with more frequent occurrence of H. pylori in the saliva samples. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3165259 Wed, 13 Jan 2010 00:00:00 +0100 3165259 http://www.medworm.com/index.php?rid=3165258&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00734.x Conclusion: Brazil presents a low prevalence of H. pylori reinfection, similar to the developed countries. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3165258 Wed, 13 Jan 2010 00:00:00 +0100 3165258 http://www.medworm.com/index.php?rid=3165257&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00735.x Conclusion: Two-week bismuth-containing quadruple therapy was more effective than the 1-week treatment, and should be considered for second-line treatment in Korea. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3165257 Wed, 13 Jan 2010 00:00:00 +0100 3165257 http://www.medworm.com/index.php?rid=3165256&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00727.x Conclusions: This intervention with high participation rates resulted in a significant decline in calculated H. pylori seroprevalence rates. Although the low prevalence of H. pylori infection may limit the cost efficiency of the program, the intervention is expected to reduce the burden of H. pylori-associated diseases. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3165256 Wed, 13 Jan 2010 00:00:00 +0100 3165256 http://www.medworm.com/index.php?rid=3165255&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00737.x Conclusions: The reported high prevalence of clarithromycin and multiple resistances of H. pylori suggest that the empiric therapy with clarithromycin should be abandoned as no longer pretreatment susceptibility testing has assessed the susceptibility of the strain. As culture and antibiogram are not routinely performable in most clinical laboratories, the use of molecular test should be developed to allow a wide availability of pretreatment susceptibility testing. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3165255 Wed, 13 Jan 2010 00:00:00 +0100 3165255 http://www.medworm.com/index.php?rid=3165254&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00738.x Conclusion: The revised Japanese guidelines for H. pylori are based on scientific evidence and avoid the administrative restraints that applied to earlier versions. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3165254 Tue, 01 Dec 2009 00:00:00 +0100 3165254 http://www.medworm.com/index.php?rid=2956446&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00728.x Background: Serological screening for gastric cancer (GC) may reduce mortality. However, optimal serum markers for advanced gastric precursor lesions are lacking.Aim: To evaluate in a case[ndash]control study whether serum leptin levels correlate with intestinal metaplasia (IM) and can serve as a tool to identify patients at high risk for GC.Materials and Methods: Cases were patients with a previous diagnosis of IM or dysplasia, controls were patients without such a diagnosis. All patients underwent endoscopy. Fasting serum was collected for the measurement of leptin, pepsinogens I/II, gastrin, and Helicobacter pylori. Receiver operating characteristic (ROC) curves and their area under the curve (AUC) were provided to compare serum leptin levels with other serological markers.Results: One ... Helicobacter journals http://www.medworm.com/rss/comments.php?id=2956446 Wed, 04 Nov 2009 00:00:00 +0100 2956446 http://www.medworm.com/index.php?rid=2956445&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00724.x Conclusion: Nonbactericidal concentrations of curcumin downregulated H. pylori-induced AID expression in gastric epithelial cells, probably via the inhibition of NF-[kappa]B pathway. Hence, curcumin can be considered as a potential chemopreventive candidate against H. pylori-related gastric carcinogenesis. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2956445 Wed, 04 Nov 2009 00:00:00 +0100 2956445 http://www.medworm.com/index.php?rid=2956444&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00717.x Conclusions: The host MMP-9 [minus]1562/TIMP-1 372 SNPs had gender differences in the risk of IM after H. pylori infection, and could possibly serve as a host factor to identify the risk group harboring gastric precancerous changes after H. pylori infection. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2956444 Wed, 04 Nov 2009 00:00:00 +0100 2956444 http://www.medworm.com/index.php?rid=2956443&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00694.x Conclusion: The LTA 252 genotype is associated with noncardia gastric cancer of diffuse type in Japan and interacted with radiation dose. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2956443 Wed, 04 Nov 2009 00:00:00 +0100 2956443 http://www.medworm.com/index.php?rid=2956442&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00725.x Conclusions: This work shows that under specific environmental conditions, H. pylori expresses a phase-variable cell-surface [alpha]-(1[rarr]4)-glucose moiety. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2956442 Wed, 04 Nov 2009 00:00:00 +0100 2956442 http://www.medworm.com/index.php?rid=2956441&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00719.x Conclusions: Helicobacter pylori infection can induce inflammatory cells infiltration, which evokes DNA damage of gastric epithelial cells through ROS and RNS production. 8-NG might be a more sensitive biomarker than 8-OHdG for H. pylori-induced DNA damage in gastric mucosa. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2956441 Wed, 04 Nov 2009 00:00:00 +0100 2956441 http://www.medworm.com/index.php?rid=2956440&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00729.x Conclusion: Helicobacter hepaticus may closely associate with diseases of the liver and biliary tract in humans. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2956440 Wed, 04 Nov 2009 00:00:00 +0100 2956440 http://www.medworm.com/index.php?rid=2956439&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00721.x Conclusion: In this selective population with very high risk of developing gastric cancer, H. pylori eradication should be considered for reimbursement with priority to prevent subsequent cancer and also reduce health care cost. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2956439 Wed, 04 Nov 2009 00:00:00 +0100 2956439 http://www.medworm.com/index.php?rid=2956438&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00723.x Conclusion: With its high-throughput and simultaneous detection abilities, H. pylori multiplex serology appears suited as tool for large seroepidemiologic studies assessing H. pylori prevalence, antibody patterns, and associations with specific diseases. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2956438 Wed, 04 Nov 2009 00:00:00 +0100 2956438 http://www.medworm.com/index.php?rid=2956437&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00720.x Conclusions: Sequential therapy using "rabeprazole and amoxicillin 7 days followed by rabeprazole, metronidazole and levofloxacin for 7 days" is a new regimen with acceptable eradication rates in naïve patients in Turkey. Further modifications in the dose or duration of this new sequential therapy might increase its effectiveness as both first and second line treatment. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2956437 Wed, 04 Nov 2009 00:00:00 +0100 2956437 http://www.medworm.com/index.php?rid=2956436&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00726.x Conclusions: Any one of biopsy-based tests or serology was found to be excellent for identifying current H. pylori infection among individuals without AG or IM and/or younger patients ( (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2956436 Wed, 04 Nov 2009 00:00:00 +0100 2956436 http://www.medworm.com/index.php?rid=2956435&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00722.x Conclusions: The standard 7-day clarithromycin-containing triple therapy is still valid as the most effective empirical first-line eradication therapy for H. pylori infection in Hong Kong, as prevalence of primary resistance of H. pylori to amoxycillin and clarithromycin remains low. Patients who failed their empirical first-line eradication therapy should undergo H. pylori susceptibility testing to guide further treatment. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2956435 Thu, 01 Oct 2009 00:00:00 +0100 2956435 http://www.medworm.com/index.php?rid=2779978&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00709.x Conclusion: The 7-day moxifloxacin-containing triple therapy produced an unacceptably low eradication rate. Increasing the duration of therapy was expected to increase the eradication rate, but the expected increased did not materialize, most likely because of coincident marked increase in the prevalence of resistance to moxifloxacin. Tailored treatment based on antibiotic susceptibility testing might be more effective in the achievement of high eradication rate when rapid antibiotic resistance such as moxifloxacin is occurring. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2779978 Thu, 10 Sep 2009 16:31:12 +0100 2779978 http://www.medworm.com/index.php?rid=2779988&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00710.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2779988 Tue, 08 Sep 2009 23:00:00 +0100 2779988 http://www.medworm.com/index.php?rid=2779987&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00705.x We examined the association between H. pylori infection and insulin resistance in a large Japanese population.Materials and Methods: Fifteen hundred ninety-eight consecutive asymptomatic subjects that underwent a complete medical survey in our institute between May 2007 and July 2008 were recruited. Cases under medication for hypertension, hyperlipidemia, diabetes mellitus, hyperuricemia, or cardiovascular diseases were excluded from the study. Cases suffering from chronic renal or liver failure were also excluded. The homeostasis model assessment of insulin resistance (HOMA-IR) score was used to quantitatively estimate insulin resistance. Visceral and subcutaneous adipose tissues (SAT) were measured by computed tomography. The association between H. pylori serostatus and HOMA-IR score was... Helicobacter journals http://www.medworm.com/rss/comments.php?id=2779987 Tue, 08 Sep 2009 23:00:00 +0100 2779987 http://www.medworm.com/index.php?rid=2779986&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00713.x Conclusion: Vaccinations with Tip[alpha] and del-Tip[alpha] were effective against H. pylori infection. The inhibition of H. pylori colonization is associated mainly with Th1 cell-mediated immunity. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2779986 Tue, 08 Sep 2009 23:00:00 +0100 2779986 http://www.medworm.com/index.php?rid=2779985&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00715.x Conclusions: The decreased FHIT gene expression associated with hereditary factors and with H. pylori infection, especially with vacA(+)cagA(+)-positive strains, may be related to gastric carcinoma development. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2779985 Tue, 08 Sep 2009 23:00:00 +0100 2779985 http://www.medworm.com/index.php?rid=2779984&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00708.x Conclusion: a4GnT genetic variation may be relevant to H. pylori infection, but not to gastric cancer risk. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2779984 Tue, 08 Sep 2009 23:00:00 +0100 2779984 http://www.medworm.com/index.php?rid=2779983&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00712.x Conclusions: The MDM2 promoter SNP309 is associated with the presence of gastric cancer in Chinese patients especially those with H. pylori infection. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2779983 Tue, 08 Sep 2009 23:00:00 +0100 2779983 http://www.medworm.com/index.php?rid=2779982&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00711.x Conclusions: Our data suggest that infection with H. pylori is associated with increased systemic inflammation. This suggests one potential mechanism to explain the extra-gastrointestinal conditions associated with H. pylori infection. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2779982 Tue, 08 Sep 2009 23:00:00 +0100 2779982 http://www.medworm.com/index.php?rid=2779981&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00716.x Conclusions: Our review suggests that supplementation with Lactobacilli could be effective in increasing eradication rates of anti-H. pylori therapy for first-treated patients. Furthermore, Lactobacilli showed a positive impact on some H. pylori therapy-related side effects. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2779981 Tue, 08 Sep 2009 23:00:00 +0100 2779981 http://www.medworm.com/index.php?rid=2779980&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00718.x Conclusions: The eradication rate with a PPI, metronidazole and amoxicillin triple therapy was unacceptably low in South China. These results suggest that studies of the eradication of H. pylori infection in China must take into account antibiotic resistance as well as patient occupation, gender, and protocol compliance. Gastric cancer and peptic ulcer disease are both important in China making methods to effectively and efficiently eradicate H. pylori a priority. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2779980 Tue, 08 Sep 2009 23:00:00 +0100 2779980 http://www.medworm.com/index.php?rid=2779979&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00714.x Conclusions: The resistance rate of H. pylori infection to clarithromycin in Japan has increased gradually to approximately 30% from 1996 through 2004, and remained unchanged since 2004. Elderly and females were at high risk of having resistance to clarithromycin. Our results suggested that the level of clarithromycin resistance in Japan has now risen to the point where it should no longer be used as empiric therapy. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2779979 Tue, 08 Sep 2009 23:00:00 +0100 2779979 http://www.medworm.com/index.php?rid=2728208&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00703.x This article presents a review of the literature on the epidemiology and public health implications of Helicobacter pylori infection published from April 2008 through to March 2009. The authors used MeSH terms "Helicobacter infections epidemiology,""Helicobacter infections prevention and control" to search multiple databases (PubMed, Embase, Cochrane, Cochrane Library, EBMR, BIOSIS), and independently searched PubMed using the term "Helicobacter" with "Epidemiology,""Transmission,""Prevalence" or "Environment." Articles without topical relevance were excluded. Two additional papers known to the authors were added. The identified literature is summarized by subtopic: reviews; prevalence; incidence; transmission; risk factors; and public health policy. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2728208 Tue, 25 Aug 2009 12:14:37 +0100 2728208 http://www.medworm.com/index.php?rid=2728218&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00701.x Non-H. pyloriHelicobacter species (NHPHS) are associated with several important human and animal diseases. In the past year research into this group of bacteria has continued to gain attention, and novel species have been described in new niches owing to improvements in detection methods. Polymerase chain reaction and/or sequencing remain the gold standard for the detection of this genus. New insights into the pathogenesis of the NHPHS in hepatobiliary, gastric, and intestinal diseases were gained. In particular, data revealed interaction between hepatic steatosis and infectious hepatitis in the development of hepatocellular carcinoma. Evidence of an association between hepatitis C virus and Helicobacter spp. in hepatocarcinoma development was also provided; and male sex hormone signaling ... Helicobacter journals http://www.medworm.com/rss/comments.php?id=2728218 Mon, 24 Aug 2009 23:00:00 +0100 2728218 http://www.medworm.com/index.php?rid=2728217&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00699.x For two decades, Helicobacter pylori has been considered as the culprit in many extragastric manifestations. However, for several of these supposed associations the hypothesis of an etiological role has not yet been fully investigated. This may be due to a series of factors linked to the epidemiological features of the studies and to the diseases investigated. This review attempts to highlight the main reported associations of H. pylori with extragastric manifestations during the last year. The most convincing data arise in the field of idiopathic thrombocytopenic purpura (ITP) and sideropenic anemia. Long-term follow-up studies have shown that 50% of subjects with ITP maintain a hematological response after H. pylori eradication. There is also growing evidence of the role of H. pylori in ... Helicobacter journals http://www.medworm.com/rss/comments.php?id=2728217 Mon, 24 Aug 2009 23:00:00 +0100 2728217 http://www.medworm.com/index.php?rid=2728216&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00700.x This review summarizes the articles published on Helicobacter pylori infection in children between April 2008 and March 2009. Recent evidence highlights the decreasing prevalence trend of H. pylori infection and supports both intrafamilial and extrafamilial transmission. The association with various symptoms is still being debated. Interestingly, H. pylori infection seems inversely associated with allergic diseases. Monoclonal stool antigen tests are widely used and accurate for the diagnosis of H. pylori infection, but less accurate in young children. The new biprobe real-time PCR assay applied to stools showed a poor sensitivity in children. Using the urea hydrolysis rate next to the delta over baseline values, the 13C-urea breath test provides excellent results for all age children, eve... Helicobacter journals http://www.medworm.com/rss/comments.php?id=2728216 Mon, 24 Aug 2009 23:00:00 +0100 2728216 http://www.medworm.com/index.php?rid=2728215&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00704.x This article aims to examine current best practice in the field reference to first-line, second-line, rescue and emerging treatment regimens for Helicobater pylori eradication. The recommended first-line treatment in published guidelines in Europe and North American is proton pump inhibitor combined with amoxicillin and clarithromycin being the favoured regimen. Rates of eradication with this regimen however are falling alarmingly due to a combination of antibiotic resistance and poor compliance with therapy. Bismuth based quadruple therapies and levofloxacin based regimes have been shown to be effective second line regimens. Third-line options include regimes based on rifabutin or furazolidone, but susceptibility testing is the most rational option here, but is currently not used widely e... Helicobacter journals http://www.medworm.com/rss/comments.php?id=2728215 Mon, 24 Aug 2009 23:00:00 +0100 2728215 http://www.medworm.com/index.php?rid=2728214&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00695.x In spite of important new insights into the basic mechanisms of gastric carcinogenesis, progress in the management of gastric cancer has been modest. Some modifications in the chemotherapies used for palliation and strategies for downstaging of the disease prior to surgical intervention are noteworthy. The positive experience with endoscopic mucosal resection (EMR) and submucosal dissection (ESD) for treatment of early gastric cancer has been confirmed and extended. The procedure-related morbidity and post-interventional quality of life is clearly favorable compared to open surgical resection in well-selected patients. New data on Helicobacter pylori revealed that eradication after endoscopic resection of early gastric cancer significantly reduces the incidence of recurrent and metachronou... Helicobacter journals http://www.medworm.com/rss/comments.php?id=2728214 Mon, 24 Aug 2009 23:00:00 +0100 2728214 http://www.medworm.com/index.php?rid=2728213&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00696.x Gastric cancer is a worldwide health burden, which is still the second most common cause of cancer related deaths with little improvement of long-term survival during the past decades. Understanding the molecular nature of this disease and its precursor lesions has been under intense investigation and our review attempts to highlight recent progress in this field of cancer research. First, host-related genetic susceptibility is dealt with genes involved in inflammation and carcinogen metabolism. Next, role of overexpression of a proinflammatory cytokine (interleukin-1beta) and deletion of a cell-cell adhesion molecule (E-cadherin) are described in experimental mouse models of gastric carcinogenesis. Finally, the role of stem cells in gastric cancer is covered. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2728213 Mon, 24 Aug 2009 23:00:00 +0100 2728213 http://www.medworm.com/index.php?rid=2728212&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00697.x It is well known that Helicobacter pylori infection is associated with many nonmalignant disorders such as gastritis, peptic ulcer, gastroesophageal reflux disease (GERD), gastric polyp, nonsteroidal anti-inflammatory drug (NSAID)/aspirin-induced gastric injury, and functional dyspepsia. In 2008, interesting articles on the association of H. pylori infection with these disorders were presented, some of which intended to reveal the mechanisms of inter-individual differences in response to H. pylori infection, and have demonstrated that genetic differences in host and bacterial factors as well as environmental factors account for these differences. A decline in the occurrence of peptic ulcer related to H. pylori was confirmed. An inverse relationship between H. pylori infection and GERD was ... Helicobacter journals http://www.medworm.com/rss/comments.php?id=2728212 Mon, 24 Aug 2009 23:00:00 +0100 2728212 http://www.medworm.com/index.php?rid=2728211&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00698.x Helicobacter pylori infects almost half of the population worldwide and represents the major cause of gastroduodenal diseases, such as duodenal and gastric ulcer, gastric adenocarcinoma, autoimmune gastritis, and B-cell lymphoma of mucosa-associated lymphoid tissue. Helicobacter pylori induces the activation of a complex and fascinating cytokine and chemokine network in the gastric mucosa. Different bacterial and environmental factors, other concomitant infections, and host genetics may influence the balance between mucosal tolerance and inflammation in the course of H. pylori infection. An inverse association between H. pylori prevalence and the frequencies of asthma and allergies was demonstrated, and the neutrophil activating protein of H. pylori was shown to inhibit the allergic inflam... Helicobacter journals http://www.medworm.com/rss/comments.php?id=2728211 Mon, 24 Aug 2009 23:00:00 +0100 2728211 http://www.medworm.com/index.php?rid=2728210&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00702.x This article will also review the recent novel findings on the interactions of H. pylori with diverse host epithelial signaling pathways and events involved in the initiation of carcinogenesis, including genetic instability and dysregulation of DNA repair. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2728210 Mon, 24 Aug 2009 23:00:00 +0100 2728210 http://www.medworm.com/index.php?rid=2728209&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00707.x The articles published this last year in the field of Helicobacter pylori diagnosis reported the development of in vivo histology, small improvements in some invasive methods (urease test, culture, and histology) and new kits for the stool antigen tests. They also contributed to increasing our knowledge, by further exploration into specific conditions for the urea breath test and into the significance of cagA antibodies. The role of serum markers of atrophy was also confirmed. Molecular methods are still being developed for direct genotyping, detection of H. pylori and its clarithromycin resistance, either by polymerase chain reaction or fluorescent in-situ hybridization. For the first time, there was a report on a possible interest of magnetic resonance spectroscopy. (Source: Helicobacter... Helicobacter journals http://www.medworm.com/rss/comments.php?id=2728209 Mon, 24 Aug 2009 23:00:00 +0100 2728209 http://www.medworm.com/index.php?rid=2632041&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00692.x Conclusions: We conclude that high numbers of transcriptionally active H. pylori are shed in vomitus, which indicates that new infections may be disseminated through vomiting. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2632041 Fri, 24 Jul 2009 10:59:49 +0100 2632041 http://www.medworm.com/index.php?rid=2632072&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.706_20.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2632072 Wed, 22 Jul 2009 23:00:00 +0100 2632072 http://www.medworm.com/index.php?rid=2632071&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.706_19.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2632071 Wed, 22 Jul 2009 23:00:00 +0100 2632071 http://www.medworm.com/index.php?rid=2632070&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.706_18.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2632070 Wed, 22 Jul 2009 23:00:00 +0100 2632070 http://www.medworm.com/index.php?rid=2632069&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.706_17.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2632069 Wed, 22 Jul 2009 23:00:00 +0100 2632069 http://www.medworm.com/index.php?rid=2632068&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.706_16.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2632068 Wed, 22 Jul 2009 23:00:00 +0100 2632068 http://www.medworm.com/index.php?rid=2632067&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.706_15.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2632067 Wed, 22 Jul 2009 23:00:00 +0100 2632067 http://www.medworm.com/index.php?rid=2632066&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.706_14.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2632066 Wed, 22 Jul 2009 23:00:00 +0100 2632066 http://www.medworm.com/index.php?rid=2632065&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.706_13.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2632065 Wed, 22 Jul 2009 23:00:00 +0100 2632065 http://www.medworm.com/index.php?rid=2632064&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.706_12.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2632064 Wed, 22 Jul 2009 23:00:00 +0100 2632064 http://www.medworm.com/index.php?rid=2632063&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.706_11.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2632063 Wed, 22 Jul 2009 23:00:00 +0100 2632063 http://www.medworm.com/index.php?rid=2632062&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.706_10.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2632062 Wed, 22 Jul 2009 23:00:00 +0100 2632062 http://www.medworm.com/index.php?rid=2632061&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.706_9.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2632061 Wed, 22 Jul 2009 23:00:00 +0100 2632061 http://www.medworm.com/index.php?rid=2632060&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.706_8.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2632060 Wed, 22 Jul 2009 23:00:00 +0100 2632060 http://www.medworm.com/index.php?rid=2632059&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.706_7.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2632059 Wed, 22 Jul 2009 23:00:00 +0100 2632059 http://www.medworm.com/index.php?rid=2632058&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.706_6.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2632058 Wed, 22 Jul 2009 23:00:00 +0100 2632058 http://www.medworm.com/index.php?rid=2632057&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.706_5.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2632057 Wed, 22 Jul 2009 23:00:00 +0100 2632057 http://www.medworm.com/index.php?rid=2632056&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.706_4.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2632056 Wed, 22 Jul 2009 23:00:00 +0100 2632056 http://www.medworm.com/index.php?rid=2632055&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.706_3.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2632055 Wed, 22 Jul 2009 23:00:00 +0100 2632055 http://www.medworm.com/index.php?rid=2632054&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.706_2.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2632054 Wed, 22 Jul 2009 23:00:00 +0100 2632054 http://www.medworm.com/index.php?rid=2632053&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.706_1.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2632053 Wed, 22 Jul 2009 23:00:00 +0100 2632053 http://www.medworm.com/index.php?rid=2632052&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00691.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2632052 Wed, 22 Jul 2009 23:00:00 +0100 2632052 http://www.medworm.com/index.php?rid=2632051&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00687.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2632051 Wed, 22 Jul 2009 23:00:00 +0100 2632051 http://www.medworm.com/index.php?rid=2632050&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00680.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2632050 Wed, 22 Jul 2009 23:00:00 +0100 2632050 http://www.medworm.com/index.php?rid=2632049&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00688.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2632049 Wed, 22 Jul 2009 23:00:00 +0100 2632049 http://www.medworm.com/index.php?rid=2632048&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00693.x Conclusions: Despite a constant birth cohort effect, H. pylori seropositivity among symptomatic veterans leveled down at ~50% after declining steadily from 1997 to 2002. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2632048 Wed, 22 Jul 2009 23:00:00 +0100 2632048 http://www.medworm.com/index.php?rid=2632047&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00689.x Conclusions: This study of a large cohort of children demonstrated that, independent of gender, H. pylori infection in the Czech Republic is among the lowest reported in Europe. Socioeconomically disadvantaged children, unfortunately, are still at risk of harboring this potentially preventable infection in this low-prevalence region. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2632047 Wed, 22 Jul 2009 23:00:00 +0100 2632047 http://www.medworm.com/index.php?rid=2632046&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00686.x Conclusion: In group B, H. pylori eradication rate was 91.25%, which is higher than the ideal 80% eradication rate. The results of the present study show that adding the prescribed doses of vitamins E and C to antimicrobial therapy is effective in eradicating H. pylori infection. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2632046 Wed, 22 Jul 2009 23:00:00 +0100 2632046 http://www.medworm.com/index.php?rid=2632045&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00683.x Conclusions: VacA has two paradoxical effects on T cells, immunosuppression, and proinflammatory effects. The latter is mediated by NF-[kappa]B activation. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2632045 Wed, 22 Jul 2009 23:00:00 +0100 2632045 http://www.medworm.com/index.php?rid=2632044&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00685.x Conclusion: H. pylori took nickel much more efficiently up than E. coli. The observed differences in urease activity are most likely due to additional protein components absent in the recombinant E. coli strain. The observed variety in nickel uptake and urease activities on the different media in the same organism depended on the intrinsic nickel content and chelating capacities of media components. Different culture conditions may lead to varying results; generalizations should be concluded only after excluding their media dependence. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2632044 Wed, 22 Jul 2009 23:00:00 +0100 2632044 http://www.medworm.com/index.php?rid=2632043&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00684.x Conclusion: Although, H. pylori strains with distinct cagA-types are circulating within the primary ethnic groups resident in Malaysia and Singapore, these genotypes appear unassociated with the development of GC in the ethnic Chinese population. The phenomenon of distinct strains circulating within different ethnic groups, in combination with host and certain environmental factors, may help to explain the rates of GC development in Malaysia. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2632043 Wed, 22 Jul 2009 23:00:00 +0100 2632043 http://www.medworm.com/index.php?rid=2632042&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00690.x Conclusion: cagA genotypes in children and in adults are different, and EPIYA-ABD may have potential clinical implication in the development of gastric cancer in South China. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2632042 Wed, 22 Jul 2009 23:00:00 +0100 2632042 http://www.medworm.com/index.php?rid=2407848&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00677.x Conclusion: H. pylori eradication may not completely abolish the risk of gastric cancer. However, eradication therapy may be used in high-risk populations to reduce gastric cancer incidence. It can reverse many biochemical, genetic, and epigenetic changes that H. pylori infection induces in the stomach. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2407848 Fri, 15 May 2009 08:48:05 +0100 2407848 http://www.medworm.com/index.php?rid=2407856&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00681.x Conclusion: Combination assay with Hp-IgG titer and pepsinogens may help identify groups at high risk for gastric cancer. Subjects with low Hp-IgG titer and mucosal atrophy were at extremely high risk for gastric cancer, particularly differentiated cancer. Subjects with this background may require ongoing observation and periodic endoscopic examination for early cancer detection. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2407856 Mon, 11 May 2009 04:00:00 +0100 2407856 http://www.medworm.com/index.php?rid=2407855&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00682.x Conclusions: Norepinephrine stimulates growth of H. pylori under otherwise growth-restricted conditions, and this effect is related to the ability of norepinephrine to bind ferric iron. This supports the notion that norepinephrine may aid H. pylori persistence in the stomach. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2407855 Mon, 11 May 2009 04:00:00 +0100 2407855 http://www.medworm.com/index.php?rid=2407854&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00679.x Conclusion: Human DCs can enter H. pylori-infected gastric epithelium, in association with other innate immunity cells, to take up bacteria and their virulence products. This process is likely to be important for bacterial sensing and pertinent immune response; however, it may also generate DC cytotoxic changes potentially hampering their function. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2407854 Mon, 11 May 2009 04:00:00 +0100 2407854 http://www.medworm.com/index.php?rid=2407853&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00675.x Conclusion: Further trials are needed. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2407853 Mon, 11 May 2009 04:00:00 +0100 2407853 http://www.medworm.com/index.php?rid=2407852&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00673.x Conclusion: The numbers of CD4+FOXP3+ T cells are increased and localized in CD4+ T-cell aggregates in areas of duodenal gastric metaplasia in duodenal ulcer patients. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2407852 Mon, 11 May 2009 04:00:00 +0100 2407852 http://www.medworm.com/index.php?rid=2407851&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00674.x Conclusions: This study demonstrates that in addition to the stomach, the large intestine of dogs is also abundantly colonized by Helicobacter spp. Additional studies are necessary to investigate the association between enterohepatic Helicobacter spp. and presence of intestinal inflammatory or proliferative disorders in dogs. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2407851 Mon, 11 May 2009 04:00:00 +0100 2407851 http://www.medworm.com/index.php?rid=2407850&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00678.x Entire Helicobacter Pylori Neutrophil Activated Protein (HPNAP) and its truncated forms NH2-terminal region HPNAP1[ndash]57 and C-terminal region HPNAP58[ndash]144 after cloning into pET29c vector, purification and removal of LPS traces were subjected to human neutrophil activation. Our results revealed that the C-terminal region of HPNAP is indispensable for human neutrophil stimulation and their further adhesion to endothelial cells [ndash] a step necessary to H. pylori inflammation [ndash] in a ratio equal to that exhibited by the entire protein. In addition, experiments concerning the implication of Arabino-Galactan-Proteins (AGPs) derived from Chios Mastic Gum (CMG), the natural resin of the plant Pistacia lentiscus var. Chia revealed the inhibition of neutrophil activation and theref... Helicobacter journals http://www.medworm.com/rss/comments.php?id=2407850 Mon, 11 May 2009 04:00:00 +0100 2407850 http://www.medworm.com/index.php?rid=2407849&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00676.x Conclusions: Infection with enterohepatic species was common in the laboratory mouse colonies tested, independent of strain and stock. Immunoblot analysis seems to be a promising diagnostic tool to monitor enterohepatic Helicobacter species infections of laboratory rodents. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2407849 Mon, 11 May 2009 04:00:00 +0100 2407849 http://www.medworm.com/index.php?rid=2251798&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00665.x Conclusions: Old age, alcohol, and smoking habits additionally promoted the risk for gastric cancer in subjects with gastric atrophy. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2251798 Wed, 11 Mar 2009 14:12:12 +0100 2251798 http://www.medworm.com/index.php?rid=2251813&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00663.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2251813 Wed, 11 Mar 2009 04:00:00 +0100 2251813 http://www.medworm.com/index.php?rid=2251811&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00662.x This study comprised 65 patients with gastroduodenal disorders: 41 patients with H. pylori infection, 13 without, and 11 patients with cured H. pylori infection. The gastric intramucosal concentrations of TAFI were measured by enzyme immunoassay. The gastric levels of TAFI and plasminogen activator inhibitor-1 were significantly increased in patients with H. pylori compared to those without infection or cured H. pylori. The presence of TAFI was detected in gastric mucosal epithelial cells. The concentration of TAFI was correlated with the degree of gastric mucosal atrophy, inflammation, and disease activity. These results show that TAFI is present in the gastric mucosa and that it may play a role in the pathogenesis of H. pylori infection-associated gastroduodenal disorders. (Source: Helic... Helicobacter journals http://www.medworm.com/rss/comments.php?id=2251811 Wed, 11 Mar 2009 04:00:00 +0100 2251811 http://www.medworm.com/index.php?rid=2251810&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00669.x Conclusion: The fldA gene may play an important role in iron starvation conditions. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2251810 Wed, 11 Mar 2009 04:00:00 +0100 2251810 http://www.medworm.com/index.php?rid=2251809&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00670.x Conclusion: The US standard 13C-UBT proved to be both simple and accurate for the diagnosis of H. pylori infections in children. The UHR method to calculate of 13C-UBT result provided excellent results for children of all ages. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2251809 Wed, 11 Mar 2009 04:00:00 +0100 2251809 http://www.medworm.com/index.php?rid=2251807&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00668.x Conclusions: H. pylori infection is common in both rural and urban regions of Beijing. Residing in a rural area, having a lower family income, and lower education level are significant risk factors associated with infection. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2251807 Wed, 11 Mar 2009 04:00:00 +0100 2251807 http://www.medworm.com/index.php?rid=2251806&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00666.x Conclusions: Our review suggests that supplementation with lactoferrin could be effective in increasing eradication rates of anti-H. pylori therapy, and could be considered helpful for patients with eradication failure. Furthermore, lactoferrin shows a positive impact on H. pylori therapy-related side-effects. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2251806 Wed, 11 Mar 2009 04:00:00 +0100 2251806 http://www.medworm.com/index.php?rid=2251804&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00671.x Conclusion: Concomitant therapy appears to be an effective alternative to triple therapy and is less complex than sequential therapy. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2251804 Wed, 11 Mar 2009 04:00:00 +0100 2251804 http://www.medworm.com/index.php?rid=2251803&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00667.x Conclusions: Our results suggest that an eradication rate of > 85% can be achieved with 14-day clarithromycin, metronidazole, and amoxicillin and 10-day clarithromycin, amoxicillin, and omeprazole regimens in Pasto, Colombia. The regimens containing clarithromycin, metronidazole, and amoxicillin appear to be superior to the clarithromycin, amoxicillin, and omeprazole regimen for compliant participants and those with atrophic gastritis. Our findings provide treatment options for a population in a developing country with a high prevalence of H. pylori infections and antibiotic resistance. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2251803 Wed, 11 Mar 2009 04:00:00 +0100 2251803 http://www.medworm.com/index.php?rid=2251802&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00664.x Conclusions: In Japan, the RAMC regimen is thought to be a promising alternative strategy for second-line eradication of H. pylori infection. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2251802 Wed, 11 Mar 2009 04:00:00 +0100 2251802 http://www.medworm.com/index.php?rid=2251800&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00672.x Conclusions: Stool antigen test, which detects present but not previous infection of H. pylori, would be applicable to diagnose H. pylori infection in mass survey. Usefulness of stool antigen tests for the screening of gastric cancer should be examined. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2251800 Wed, 11 Mar 2009 04:00:00 +0100 2251800 http://www.medworm.com/index.php?rid=2109948&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00660.x Conclusion: The results of the current study demonstrated a counteractive Th1 and Th2 cytokine interaction between H. pylori infection and atopy. However, this counteractive immunologic balance did not protect against atopy. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2109948 Sat, 17 Jan 2009 05:43:18 +0100 2109948 http://www.medworm.com/index.php?rid=2109959&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00661.x Conclusions: Rodents are frequently colonized by a variety of enterohepatic Helicobacter species, and this may affect their global health status and intestinal inflammatory responses. Animal facilities should have treatment strategies for Helicobacter infections, and hence resistance of enterohepatic Helicobacter species to amoxicillin should be considered when designing eradication programs. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2109959 Thu, 15 Jan 2009 05:00:00 +0100 2109959 http://www.medworm.com/index.php?rid=2109958&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00652.x Conclusion: Use of the HRII-51 antigen capture ELISA would be a useful approach for the serodiagnosis of H. hepaticus infection in both experimental animals and humans. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2109958 Thu, 15 Jan 2009 05:00:00 +0100 2109958 http://www.medworm.com/index.php?rid=2109957&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00655.x Conclusions: Drug resistance to ciprofloxacin and levofloxacin in H. pylori collected from 2004 to 2007 increased significantly compared with resistance level observed during 1998[ndash]2003. The continuous surveillance of quinolone resistance among H. pylori is important in this area. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2109957 Thu, 15 Jan 2009 05:00:00 +0100 2109957 http://www.medworm.com/index.php?rid=2109956&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00653.x Conclusion: There should be a gender difference to circulating total ghrelin levels, but not leptin levels, in response to H. pylori infection and its related chronic gastritis. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2109956 Thu, 15 Jan 2009 05:00:00 +0100 2109956 http://www.medworm.com/index.php?rid=2109955&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00659.x Conclusion: Our study found that TLR4+3725 G/C polymorphism was a risk factor of severe gastric atrophy in H. pylori seropositive Japanese. Our results underscored the significance of the variations in host innate immunity due to TLR4 polymorphism as genetic predispositions to gastric precancerous lesions in Eastern Asian populations with the same backgrounds. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2109955 Thu, 15 Jan 2009 05:00:00 +0100 2109955 http://www.medworm.com/index.php?rid=2109954&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00657.x Conclusions: The rate of prevalence of H. pylori infection was higher than developed countries. Low socioeconomic status, poor sanitary indications, and crowded families in childhood were related to high prevalence of H. pylori infection in Iran. Accordingly, fecal[ndash]oral and oral[ndash]oral routes could be considered as the main pathways of transmission of H. pylori. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2109954 Thu, 15 Jan 2009 05:00:00 +0100 2109954 http://www.medworm.com/index.php?rid=2109953&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00658.x Conclusion: In the iron-depleted state, specific H. pylori strains associated with IDA demonstrated an advantage in iron acquisition due to a higher expression of IROMPs. Our results can explain in part why some patients with H. pylori infection are more prone to develop clinical IDA under restricted iron conditions in the host. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2109953 Thu, 15 Jan 2009 05:00:00 +0100 2109953 http://www.medworm.com/index.php?rid=2109952&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00656.x Conclusions: For all antimicrobial combinations, 14 days protocols have led to a significant increase of H. pylori eradication success when compared to 10 and 7 days, respectively. Prolonging the treatment duration can overcome the negative effect of metronidazole resistance. Only PAM14, PACl10 protocols achieved ITT success > 80% and should be recommended as the first line eradication treatment in Croatia. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2109952 Thu, 15 Jan 2009 05:00:00 +0100 2109952 http://www.medworm.com/index.php?rid=2109951&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00654.x Conclusions: DPO-based multiplex PCR can be used as a practical method for the detection of H. pylori infection and the determination of clarithromycin susceptibility in addition to phenotypic antimicrobial susceptibility tests. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2109951 Thu, 15 Jan 2009 05:00:00 +0100 2109951 http://www.medworm.com/index.php?rid=2109950&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00650.x Conclusions: High resolution magnifying is superior to standard endoscopy for the diagnosis of H. pylori gastritis, and identification of specific histopathologic features such as atrophy and intestinal metaplasia seems possible. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2109950 Thu, 15 Jan 2009 05:00:00 +0100 2109950 http://www.medworm.com/index.php?rid=2109949&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00651.x We describe a patient with IgA antibodies against C1-INH without other autoimmune markers. Our patient had gastritis and Helicobacter pylori infection, proven by biopsy. This case suggests that H. pylori infection can act as triggering factor for acquired autoimmune angioneurotic edema. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=2109949 Thu, 15 Jan 2009 05:00:00 +0100 2109949 http://www.medworm.com/index.php?rid=1951023&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2008.00649.x Conclusions: Both once-daily triple (rabeprazole, levofloxacin, and furazolidone) and twice-daily quadruple therapy (rabeprazole, bismuth subcitrate, doxycycline, and furazolidone) for 10 days achieved encouraging results. Subsequent studies should be performed to evaluate antibiotic resistance, doses, dosing intervals, duration of treatment, and safety of these two regimes. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=1951023 Tue, 11 Nov 2008 05:00:00 +0100 1951023 http://www.medworm.com/index.php?rid=1951022&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2008.00647.x Conclusions: Our results suggest that H. pylori eradication therapy might improve the ulcer healing rate after EMR. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=1951022 Tue, 11 Nov 2008 05:00:00 +0100 1951022 http://www.medworm.com/index.php?rid=1951021&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2008.00642.x Conclusions: Culture on four-sector agar plates and FISH test had a high sensitivity and specificity and showed co-presence of sensitive and resistant strains. In one-third of children with mixed infection, the resistant strains were in the fundus only. Clarithromycin resistance should be assessed in biopsies both from the antrum and the fundus, utilizing antral biopsies only can underestimate its prevalence. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=1951021 Tue, 11 Nov 2008 05:00:00 +0100 1951021 http://www.medworm.com/index.php?rid=1951020&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2008.00628.x Conclusions: The two treatments gave similar eradication rates. Significant differences for both treatments were found by weight, which could be the result of the once-daily proton pump inhibitor and clarithromycin and/or more antibiotic resistant strains in younger children. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=1951020 Tue, 11 Nov 2008 05:00:00 +0100 1951020 http://www.medworm.com/index.php?rid=1951019&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2008.00648.x Conclusion: The results of this study showed that lafutidine[ndash]clarithromycin[ndash]amoxicillin therapy was a safe and effective as lansoprazole-based triple therapy for the eradication rate of H. pylori, and could be considered as an additional treatment option. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=1951019 Tue, 11 Nov 2008 05:00:00 +0100 1951019 http://www.medworm.com/index.php?rid=1951018&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2008.00643.x Conclusion: The efficacy of omeprazole- and lansoprazole-based first-line triple therapies at the standard doses is dependent on CYP2C19 genotype status, which appears not to affect the efficacy of the regimens including rabeprazole. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=1951018 Tue, 11 Nov 2008 05:00:00 +0100 1951018 http://www.medworm.com/index.php?rid=1951017&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2008.00627.x Conclusions: Infection with H. pylori CagA-positive strains increases the risk of recurrent atherosclerotic stroke. Seropositivity determination should be performed in order to identify high-risk patients requiring a strict clinical surveillance, and the possible beneficial effect of eradication therapy should be evaluated. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=1951017 Tue, 11 Nov 2008 05:00:00 +0100 1951017 http://www.medworm.com/index.php?rid=1951016&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2008.00629.x Conclusions: These results suggest that IL-17 may play an important role in the inflammatory response to the H. pylori infection and ultimately influence the outcome of the H. pylori-associated disease. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=1951016 Tue, 11 Nov 2008 05:00:00 +0100 1951016 http://www.medworm.com/index.php?rid=1951015&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2008.00646.x Conclusion: H. pylori might trigger apoptosis in AGS cells via interaction with death receptors in the plasma membrane, leading to the cleavage of procaspase-8, release of cytochrome c and AIF from mitochondria, and activation of subsequent downstream apoptotic events, as reported previously for chlorophyllin. This is consistent with AIF activation that was found in the gastric mucosa of humans infected with H. pylori. Hence, the balance between apoptosis and proliferation in these cells may be altered in response to injury caused by H. pylori infection, leading to an increased risk of cancer. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=1951015 Tue, 11 Nov 2008 05:00:00 +0100 1951015 http://www.medworm.com/index.php?rid=1951014&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2008.00641.x Conclusions: The predominance, heterogeneity, and distribution of natural killer cell receptor-positive T-cells at different locations within the gastric mucosa reflects a potential functional role during H. pylori infection and warrants further investigation. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=1951014 Tue, 11 Nov 2008 05:00:00 +0100 1951014 http://www.medworm.com/index.php?rid=1951013&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2008.00640.x Conclusions: Subcutaneous vaccination using unadjuvanted formalin-fixed H. pylori has the potential to be a simple, cost-effective approach to the development of a Helicobacter vaccine. Importantly, this vaccine was able to induce protection against heterologous challenge, a factor that would be crucial in any human Helicobacter vaccine. Further studies are required to determine mechanisms of protection and to improve protective ability. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=1951013 Tue, 11 Nov 2008 05:00:00 +0100 1951013 http://www.medworm.com/index.php?rid=1951012&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2008.00644.x Conclusions: This demonstrates a variable effect of Muc1 on protection against closely related adherent and nonadherent Helicobacter species, and supports a key role for Muc1 in limiting attachment of adherent bacteria to the gastric mucosal surface. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=1951012 Wed, 01 Oct 2008 04:00:00 +0100 1951012 http://www.medworm.com/index.php?rid=1699746&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2008.00622.x We challenge the concept of idiopathic parkinsonism (IP) as inevitably progressive neurodegeneration, proposing a natural history of sequential microbial insults with predisposing host response. Proof-of-principle that infection can contribute to IP was provided by case studies and a placebo-controlled efficacy study of Helicobacter eradication. "Malignant" IP appears converted to "benign", but marked deterioration accompanies failure. Similar benefit on brady/hypokinesia from eradicating "low-density" infection favors autoimmunity. Although a minority of UK probands are urea breath test positive for Helicobacter, the predicted probability of having the parkinsonian label depends on the serum H. pylori antibody profile, with clinically relevant gradients between this "discriminant index" a... Helicobacter journals http://www.medworm.com/rss/comments.php?id=1699746 Wed, 13 Aug 2008 09:35:11 +0100 1699746 http://www.medworm.com/index.php?rid=1685563&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2008.00631.x This review summarizes studies on the epidemiology of Helicobacter pylori published in peer-reviewed journals between April 2007 and March 2008. Infection with H. pylori often occurs in childhood, and once established, can persist lifelong if untreated. Prevalence of H. pylori infection is higher in developing countries when compared to developed countries, and can vary by ethnicity, place of birth, and socioeconomic factors even among persons living in the same country. Prevalence of infection is decreasing in many countries due to improvements in sanitation and living standards and the relatively recent movement of populations from rural to urban settings; however, post-treatment recurrence rates of H. pylori infection remain high in developing countries, and in given populations within ... Helicobacter journals http://www.medworm.com/rss/comments.php?id=1685563 Thu, 07 Aug 2008 08:21:53 +0100 1685563 http://www.medworm.com/index.php?rid=1685571&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2008.00634.x The finding that Helicobacter pylori is the main cause of gastritis and peptic ulcer disease has opened a new era in the gastrointestinal world. Today there is evidence that H. pylori may also play a role in different nongastric diseases, opening the new "extragastric manifestations of H. pylori infection" field. Concerning this, several studies have been published in the last year. The most convincing data arise from those investigating idiopathic thrombocytopenic purpura and sideropenic anemia, while there is also an increasing evidence for a possible association with atherosclerotic disease. Furthermore, the discovery of a number of other novel Helicobacter species has stimulated the research in different extragastric diseases, in which an infectious hypothesis is plausible. In particul... Helicobacter journals http://www.medworm.com/rss/comments.php?id=1685571 Wed, 06 Aug 2008 04:00:00 +0100 1685571 http://www.medworm.com/index.php?rid=1685570&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2008.00632.x This study suggests that the reduced inflammatory response to H. pylori at a cellular level in children could be the consequence of an enhanced Treg cell response, which in turn down-regulates H. pylori-induced inflammation. The publication of the Paediatric European Register for Treatment of Helicobacter pylori study (PERTH) is important as it demonstrates the advantages of different centers working in collaboration for the benefit of children. It also highlights the fact that while bismuth-based treatment is more effective than proton pump inhibitor-based treatment in children, bismuth preparations are not widely available for use in children. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=1685570 Wed, 06 Aug 2008 04:00:00 +0100 1685570 http://www.medworm.com/index.php?rid=1685569&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2008.00639.x Antibiotic resistance has resulted in unsatisfactory eradication results with dual and now triple therapy in many countries. Newer antibiotics and changes in dosing and duration of therapy may overcome resistant strains but may only provide limited improvement in eradication rates. Sequential therapy with amoxicillin (1 g twice a day) and a proton pump inhibitor (PPI) (twice a day) given for 5 days followed by a PPI plus clarithromycin (500 mg twice a day) and tinidazole (500 mg twice a day) for 5 days is now a first-line therapy for Helicobacter pylori in some countries. Standard triple therapy is effective in regions where clarithromycin resistance is low. Levofloxacin based triple therapy is an effective alternative to quadruple therapy in second-line treatment. Adjuvant therapy may red... Helicobacter journals http://www.medworm.com/rss/comments.php?id=1685569 Wed, 06 Aug 2008 04:00:00 +0100 1685569 http://www.medworm.com/index.php?rid=1685568&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2008.00633.x Individuals infected with Helicobacter pylori, a stomach colonizing bacteria, have an increased risk of developing gastric malignancies. The risk for developing cancer relates to the physiologic and histologic changes that H. pylori infection induces in the stomach. In the last year numerous studies have been conducted in order to characterize the association between H. pylori infection and gastric cancer. These studies range from epidemiologic approaches aiming at the identification of environmental, host genetic, and bacterial factors associated with risk of gastric cancer, to molecular and cell biology approaches aiming at understanding the interaction between H. pylori and the transforming epithelial cell. In this review an account of the last year's research activity on the relationsh... Helicobacter journals http://www.medworm.com/rss/comments.php?id=1685568 Wed, 06 Aug 2008 04:00:00 +0100 1685568 http://www.medworm.com/index.php?rid=1685567&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2008.00635.x In 2007 Helicobacter pylori research continued to deal with some controversies raised in the last decade. The main problems remain unsolved: peptic ulcer disease negative for H. pylori, synergism of H. pylori infection and aspirin and other nonsteroidal anti-inflammatory drugs or cyclooxygenase 2 specific inhibitors, the role of H. pylori eradication in uninvestigated and nonulcer dyspepsia, and the possible protective effect of H. pylori infection against gastroesophageal reflux disease and its complications such as Barrett's esophagus and adenocarcinoma. The incidence and prevalence of peptic ulcer disease as well as ulcer-related mortality are continuing to decline all over the world. The increasing consumption of anti-inflammatory and antisecretory drugs was not found to change the tre... Helicobacter journals http://www.medworm.com/rss/comments.php?id=1685567 Wed, 06 Aug 2008 04:00:00 +0100 1685567 http://www.medworm.com/index.php?rid=1685566&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2008.00636.x Helicobacter pylori infection causes chronic gastritis, peptic ulcer, and gastric cancer. Colonization of H. pylori in the stomach activates Toll-like and Nod-like receptors to induce not only innate immunity but also adaptive Th1 responses against this organism. Adaptive Th1 response is not sufficient to clear this organism and, as a result, the infection persists. Insufficient adaptive immunity can be explained by poor activation of Toll-like receptors, suppressive effects of bacterial factors, and induction of regulatory T-cell responses. Significant progress in the understanding of innate and adaptive immunity against H. pylori was made during the past year. Recent findings in the fields of vaccines for H. pylori are also reviewed. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=1685566 Wed, 06 Aug 2008 04:00:00 +0100 1685566 http://www.medworm.com/index.php?rid=1685565&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2008.00630.x The clinical outcome of Helicobacter pylori infection is determined by a complex scenario of interactions between the bacterium and the host. The main bacterial factors associated with colonization and pathogenicity comprise outer membrane proteins including BabA, SabA, OipA, AlpA/B, as well as the virulence factors CagA in the cag pathogenicity island (cagPAI) and the vacuolating cytotoxin VacA. The multitude of these proteins and allelic variation makes it extremely difficult to test the contribution of each individual factor. Much effort has been put into identifying the mechanism associated with H. pylori-associated carcinogenesis. Interaction between bacterial factors such as CagA and host signal transduction pathways seems to be critical for mediating the induction of membrane dynami... Helicobacter journals http://www.medworm.com/rss/comments.php?id=1685565 Wed, 06 Aug 2008 04:00:00 +0100 1685565 http://www.medworm.com/index.php?rid=1685564&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2008.00637.x The different invasive and noninvasive diagnostic tests for Helicobacter pylori have been applied mainly in emerging countries. Molecular methods have been developed, especially a test for detection of H. pylori and its clarithromycin resistance directly from stools. The long-term effects of eradication on histologic lesions have been studied in a meta-analysis and the prognostic value of post-treatment in gastric mucosa-associated lymphoid tissue lymphoma has been assessed. An operating link for gastritis assessment (the OLGA staging) has also been published. Attempts to simplify the urea breath test protocol have been made, and new stool antigen tests have been proposed and compared to those previously available. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=1685564 Wed, 06 Aug 2008 04:00:00 +0100 1685564 http://www.medworm.com/index.php?rid=1614864&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2008.00619.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=1614864 Sun, 13 Jul 2008 08:30:42 +0100 1614864 http://www.medworm.com/index.php?rid=1614877&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2008.00618.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=1614877 Tue, 08 Jul 2008 04:00:00 +0100 1614877 http://www.medworm.com/index.php?rid=1614876&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2008.00613.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=1614876 Tue, 08 Jul 2008 04:00:00 +0100 1614876 http://www.medworm.com/index.php?rid=1614875&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2008.00612.x Conclusion: This study demonstrates that H. pylori-induced gastritis is associated with a recruitment of naturally occurring FOXP3+ Treg cells that correlates with the degree of bacterial colonization and mucosal TGF-[beta]1 expression. Together, these data support the hypothesis that naturally FOXP3+ Treg cells play a role in the lifelong persistence of H. pylori infection in humans. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=1614875 Tue, 08 Jul 2008 04:00:00 +0100 1614875 http://www.medworm.com/index.php?rid=1614874&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2008.00616.x Conclusion: The results of this study showed that H. pylori IgG serology could be used for the determination of reinfection of H. pylori, but not for the diagnosis of H. pylori eradication. The reinfection rate of H. pylori, in Korea, was found to be very low, 2.94% per year. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=1614874 Tue, 08 Jul 2008 04:00:00 +0100 1614874 http://www.medworm.com/index.php?rid=1614873&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2008.00615.x Conclusions: Amoxicillin regimens with PPI and clarithromycin are found to be equally effective and safe in both the BID and QID groups for H. pylori eradication. Therefore, considering patient's comfort, we recommend a twice daily amoxicillin regimen. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=1614873 Tue, 08 Jul 2008 04:00:00 +0100 1614873 http://www.medworm.com/index.php?rid=1614872&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2008.00611.x Conclusions: The results of the present study require a careful interpretation because of the retrospective analysis. In high-risk countries of gastric cancer, however, eradicating H. pylori in childhood could prove more effective in preventing gastric atrophy, ultimately, the development of cancer. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=1614872 Tue, 08 Jul 2008 04:00:00 +0100 1614872 http://www.medworm.com/index.php?rid=1614871&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2008.00610.x Conclusions: Our findings suggest that CagA-positive strains of H. pylori are significantly associated to atherosclerotic stroke. This is not a merely confirmative study since it has been performed for the first time in the primary care setting and included only subjects with an active infection. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=1614871 Tue, 08 Jul 2008 04:00:00 +0100 1614871 http://www.medworm.com/index.php?rid=1614870&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2008.00598.x Conclusions: The findings have demonstrated Premium Platinum HpSA PLUS to be a reliable method for detection of H. pylori infection also in children in our area. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=1614870 Tue, 08 Jul 2008 04:00:00 +0100 1614870