MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Helicobacter' source. Wed, 08 Feb 2012 16:28:18 +0100 http://www.medworm.com/index.php?rid=5560964&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00914.x Conclusions:  AlbuMAX II® (Gibco BRL) can be used as a serum/blood replacement for the cultivation of H. pylori in solid and liquid media. This medium could be useful for an improved understanding of H. pylori metabolism or for antigen production. Furthermore, AlbuMAX II® (Gibco BRL) may be suitable for use in remote locations, particularly in areas where frozen storage of serum may be a problem. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5560964 Thu, 05 Jan 2012 16:46:08 +0100 5560964 http://www.medworm.com/index.php?rid=5560963&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00913.x Conclusions:  This study reports the isolation of two mucoid strains of H. pylori with confluent growth under aerobic and microaerobic conditions. It appears that production of exopolysaccharide (EXP) could serve as a physical barrier to reduce oxygen diffusion into the bacterial cell and uptake of antibiotics. EXP protected the mucoid H. pylori isolates against stressful conditions, the result of which could be persistence of bacterial infection in the stomach. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5560963 Thu, 05 Jan 2012 16:46:06 +0100 5560963 http://www.medworm.com/index.php?rid=5560962&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00917.x Conclusions:  Under the assumption that sanitary, sociocultural, and dietary habits have not changed over the years, we can conclude that an increased risk of H. pylori was associated with unsanitary practices whereas protection was associated with consumption of tea and locally produced foods, “pegaga” and “budu.” These dietary factors are candidates for future study on the effects on H. pylori transmission. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5560962 Thu, 05 Jan 2012 16:46:04 +0100 5560962 http://www.medworm.com/index.php?rid=5560961&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00911.x Conclusion:  A 10‐day concomitant regimen appears to be an effective, safe, and well‐tolerated treatment option for first‐line H. pylori eradication in Greece. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5560961 Thu, 05 Jan 2012 16:46:02 +0100 5560961 http://www.medworm.com/index.php?rid=5560960&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00896.x Conclusion:  Because the two regimens showed acceptable and similar abilities in H. pylori eradication and because of much higher cost of clarithromycin in Iran, the furazolidone containing regimen seems to be superior. Further modifications of sequential therapies are needed to make them ideal regimens in developing countries. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5560960 Thu, 05 Jan 2012 16:46:00 +0100 5560960 http://www.medworm.com/index.php?rid=5560959&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00912.x Conclusion:  Mutation from Asn to Lys at position 87 of GyrA confers higher resistance to levofloxacin and gatifloxacin than does mutation from Asp to Asn at position 91. We propose that mutation at position 463 in GyrB as a novel mechanism of fluoroquinolone resistance in H. pylori. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5560959 Thu, 05 Jan 2012 16:45:58 +0100 5560959 http://www.medworm.com/index.php?rid=5560958&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00895.x Conclusions:  We demonstrate an inverse association between H. pylori and pediatric asthma in a population with a high prevalence of H. pylori. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5560958 Thu, 05 Jan 2012 16:45:57 +0100 5560958 http://www.medworm.com/index.php?rid=5560957&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00894.x Conclusion:  Factors linked to remain and to gain H. pylori infection in a poor region were increased number of children in the household and the male gender. Also, the acquisition rates were higher than the loss rates, which lead to an increase in the infection prevalence with age. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5560957 Thu, 05 Jan 2012 16:45:55 +0100 5560957 http://www.medworm.com/index.php?rid=5560956&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00893.x Conclusions:  Arginine 66 but not histidine 99 in H. pylori Fur is required for the regulatory function of the Fur protein in the acid adaptation mechanism of the bacterium. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5560956 Thu, 05 Jan 2012 16:45:53 +0100 5560956 http://www.medworm.com/index.php?rid=5560955&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00892.x Conclusions:  Meta‐analyses indicate that H. pylori infection is associated with reduced levels of ascorbic acid and cobalamin, supported by the positive effect of eradication treatment. For other micronutrients, further studies are needed. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5560955 Thu, 05 Jan 2012 16:45:51 +0100 5560955 http://www.medworm.com/index.php?rid=5560954&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00898.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5560954 Thu, 05 Jan 2012 16:45:49 +0100 5560954 http://www.medworm.com/index.php?rid=5409344&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00871.x Conclusions:  Focally enhanced inflammation is characteristic for gastric erosions. This focal inflammation was associated with HSV seropositivity or NSAID use suggesting that such inflammation may be important in the pathogenesis of gastric antral erosions. Highly active inflammation in the erosions associates with their chronicity. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5409344 Thu, 17 Nov 2011 00:15:07 +0100 5409344 http://www.medworm.com/index.php?rid=5388366&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00920.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5388366 Thu, 10 Nov 2011 10:20:53 +0100 5388366 http://www.medworm.com/index.php?rid=5388365&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00897.x Conclusion:  These results indicate that the heterogeneity of human Le phenotypes is reflected in their H. pylori colonizing strains and suggest new loci that can be studied to assess the variation of Le expression. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5388365 Thu, 10 Nov 2011 10:20:51 +0100 5388365 http://www.medworm.com/index.php?rid=5388364&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00872.x Conclusions:  A test‐and‐treat system was possible to implement that allowed patients to perform UBTs at their homes. The results of the first‐time UBTs demonstrated that approximately one of five patients who presented with dyspepsia in the clinical setting of Danish primary care was infected with H. pylori. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5388364 Thu, 10 Nov 2011 10:20:50 +0100 5388364 http://www.medworm.com/index.php?rid=5388363&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00860.x Conclusions:  Anti‐α1,6‐glucan mAbs could have potential application in typing and surveillance of H. pylori isolates as well as offer insights into structural requirements for the development of LPS‐based vaccine against H. pylori infections. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5388363 Thu, 10 Nov 2011 10:20:49 +0100 5388363 http://www.medworm.com/index.php?rid=5388362&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00866.x Conclusions:  PAR2 represents an additive pathway of IL‐8 secretion and proinflammatory effects in H. pylori‐induced gastritis. Reduced SLPI levels leading to higher serine protease activities in the mucosa of infected subjects might regulate PAR2 activation. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5388362 Thu, 10 Nov 2011 10:20:47 +0100 5388362 http://www.medworm.com/index.php?rid=5388361&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00871.x Conclusions:  Focally enhanced inflammation is characteristic for gastric erosions. This focal inflammation was associated with HSV seropositivity or NSAID use suggesting that such inflammation may be important in the pathogenesis of gastric antral erosions. Highly active inflammation in the erosions associates with their chronicity. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5388361 Thu, 10 Nov 2011 10:20:46 +0100 5388361 http://www.medworm.com/index.php?rid=5388360&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00864.x Conclusions:  The urushiol has an antibacterial effect against H. pylori infection and can be used safely for H. pylori eradication in a mouse model. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5388360 Thu, 10 Nov 2011 10:20:44 +0100 5388360 http://www.medworm.com/index.php?rid=5388359&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00868.x Conclusions:  The relationship between acid secretion and H. pylori antibody concentration differs depending on the presence of mucosal atrophy. Our findings provide a possible rationalization for measuring both serum pepsinogen levels and H. pylori antibody concentration in gastric cancer screening. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5388359 Thu, 10 Nov 2011 10:20:43 +0100 5388359 http://www.medworm.com/index.php?rid=5388358&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00867.x Conclusion:  Second‐line/rescue H. pylori eradication therapy with esomeprazole, moxifloxacin, and amoxicillin is very effective and well tolerated. Fourteen days of treatment significantly increase the eradication rate but also the rate of adverse events. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5388358 Thu, 10 Nov 2011 10:20:41 +0100 5388358 http://www.medworm.com/index.php?rid=5388357&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00889.x Conclusion:  The prevalence of HpNGC is very low and its pathological characteristics are different from common gastric cancer. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5388357 Thu, 10 Nov 2011 10:20:40 +0100 5388357 http://www.medworm.com/index.php?rid=5388356&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00921.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5388356 Thu, 10 Nov 2011 10:20:38 +0100 5388356 http://www.medworm.com/index.php?rid=5238810&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00870.x Conclusions:  A retrial of quadruple therapy before use of a third‐line therapy may be safe and effective for patients who fail to respond to second‐line quadruple therapy. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5238810 Thu, 22 Sep 2011 10:04:37 +0100 5238810 http://www.medworm.com/index.php?rid=5238809&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00854.x Conclusion:  The prevalence of H. pylori in childhood has remained stable in the Netherlands from 1993 to 2005, suggesting a stabilization of the previously decreasing trend in subsequent birth cohorts. This finding may reflect stabilization in determinants such as family size, housing, and hygienic conditions (or offset by day care). If confirmed in other populations in developed countries, it implies that colonization with H. pylori will remain common in the coming decades. Remarkably however, the rate of colonization with cagA+H. pylori strains has become very low, consistent with prior observations that cagA+ strains are disappearing in Western countries. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5238809 Thu, 22 Sep 2011 10:04:36 +0100 5238809 http://www.medworm.com/index.php?rid=5238808&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00861.x Conclusion:  We provide evidence showing that MyD88‐dependent signaling is required for the host to induce a Th17 response for the control of Helicobacter infection. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5238808 Thu, 22 Sep 2011 10:04:35 +0100 5238808 http://www.medworm.com/index.php?rid=5238807&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00862.x Conclusions:  Long‐term H. pylori colonization affected the distribution and numbers of indigenous microflora in stomach and duodenum. Successful colonization caused a more severe gastritis. Gastric microenvironment may be unfit for lactobacilli fertility after long‐term H. pylori infection, while enterococci, S. aureus, bifidobacteria, and bacteroides showed their adaptations. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5238807 Thu, 22 Sep 2011 10:04:33 +0100 5238807 http://www.medworm.com/index.php?rid=5238806&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00859.x Conclusion:  At least 5.4% cases of gastric cancer were H. pylori negative among South Korean patients. HPIN‐GC looks like to have a poorer prognosis than H. pylori‐positive cases. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5238806 Thu, 22 Sep 2011 10:04:31 +0100 5238806 http://www.medworm.com/index.php?rid=5238805&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00855.x Conclusion: H. pylori could inhibit the differentiation of T lymphocytes toward Th2 cells, promote the Th1 cell differentiation, and induce Th1‐biased immune response. The expression of Tim‐1 and Tim‐3 could reflect Th2 and Th1 immune response, respectively, which provide evidence for the prevention and treatment of H. pylori infection and correlation diseases through regulation of Tim‐1 and Tim‐3. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5238805 Thu, 22 Sep 2011 10:04:30 +0100 5238805 http://www.medworm.com/index.php?rid=5238804&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00858.x Conclusions:  The prevalence of H. pylori infection in the Portuguese pediatric population is still high. Although this study confirmed that the highest acquisition rate occurs at young age, it showed that in high‐prevalence populations, older children can also acquire H. pylori infection at a rate similar to that of young children. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5238804 Thu, 22 Sep 2011 10:04:28 +0100 5238804 http://www.medworm.com/index.php?rid=5238803&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00856.x Conclusion:  The high prevalence of primary antibiotic resistance was out of expectation in H. pylori strains isolated from the children in Beijing. Antibiotic susceptibility should be made clear before the antibiotic was used in the anti‐H. pylori therapy in this population. The A2143G was the most populated mutation in macrolide‐resistant strains, and Asn87 and Asp91 of GyrA were the most common mutation points in quinolone resistance strains. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5238803 Thu, 22 Sep 2011 10:04:26 +0100 5238803 http://www.medworm.com/index.php?rid=5238802&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00890.x AbstractBackground & objectives:  The aim of this document is to provide a methodological framework and to review key aspects for adequately designing trials to evaluate new treatments for Helicobacter pylori infection.Methods:  Non‐systematic literature review.Results & conclusions:  Regarding the design of the article, we suggest selecting for future trials drugs to which H. pylori has no significant primary resistances and evaluating therapies with pilot studies before engaging in randomized trials. The manuscript defines how the number and type of H. pylori diagnostic tests necessary before and after the trial depend on the setting and reliability of the tests. It recommends the best methods and timing for H. pylori testing before and after therapy. Other recommendat... Helicobacter journals http://www.medworm.com/rss/comments.php?id=5238802 Thu, 22 Sep 2011 10:04:25 +0100 5238802 http://www.medworm.com/index.php?rid=5238801&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00891.x AbstractWe discuss the role of comparators in Helicobacter pylori treatment trials and why anti‐H. pylori therapeutic trials (an infectious disease) are fundamentally different from common gastrointestinal diseases (e.g., the absence of a placebo response, the expectation that cure rates in excess of 95%, and the ability to understand why treatment fails). No comparator is absolutely required other than to 100% success and comparison trials should be limited to comparisons between therapies that reliably achieve 90% or greater success (i.e., good therapies). Comparisons with known low success regimens (i.e., bad therapies) are unethical as is withholding information from the subject regarding current effectiveness of a regimen even if that information would reduce the likelihood that th... Helicobacter journals http://www.medworm.com/rss/comments.php?id=5238801 Thu, 22 Sep 2011 10:04:23 +0100 5238801 http://www.medworm.com/index.php?rid=5238800&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00910.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5238800 Thu, 22 Sep 2011 10:04:22 +0100 5238800 http://www.medworm.com/index.php?rid=5209840&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00888.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5209840 Thu, 01 Sep 2011 04:00:00 +0100 5209840 http://www.medworm.com/index.php?rid=5209839&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00887.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5209839 Thu, 01 Sep 2011 04:00:00 +0100 5209839 http://www.medworm.com/index.php?rid=5209838&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00886.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5209838 Thu, 01 Sep 2011 04:00:00 +0100 5209838 http://www.medworm.com/index.php?rid=5209837&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00885.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5209837 Thu, 01 Sep 2011 04:00:00 +0100 5209837 http://www.medworm.com/index.php?rid=5209836&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00884.x AbstractThe last year has seen an interesting and important collection of evidence presented in the field of the “other” than Helicobacter pylori Helicobacters. Associations with adult ulcerative colitis and biliary/hepatic disease have been described. New insights into the immune response and subsequent pathogenesis associated with infection have also been published. Genomic advances include description of new and unique species and the complete genome description for both Helicobacter felis and Helicobacter suis. Molecular studies have also elucidated the mechanism of action of some functional components of these organisms. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5209836 Thu, 01 Sep 2011 04:00:00 +0100 5209836 http://www.medworm.com/index.php?rid=5209835&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00883.x AbstractIn the previous year, some extragastric diseases, possibly linked to Helicobacter pylori infection, have been largely investigated. There are, in fact, several studies concerning cardiovascular diseases, lung diseases, hematologic diseases, eye and skin diseases, hepatobiliary diseases, diabetes mellitus, and neurological disorders. Among them, the relationship between bacterial CagA positivity and coronary heart disease is reportedly emphasized. Concerning normal tension glaucoma, new interesting data are playing in favor of the association with H. pylori infection. For other diseases, there are many interesting results, although more studies are needed to clarify the reality of the proposed association. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5209835 Thu, 01 Sep 2011 04:00:00 +0100 5209835 http://www.medworm.com/index.php?rid=5209834&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00882.x This article reviewed the important publications on Helicobacter pylori research with children between April 2010 and March 2011. The most interesting studies in the last year lend further weight to the evidence for vertical transmission of H. pylori. The discovery of a potential role for jhp0562, the gene which encodes for the cell envelope protein glycosyltransferase, in the progression to peptic ulcer disease is also very interesting as it may provide a novel way to distinguish children at risk of peptic ulcer disease from those who are not, and so determine those who requires treatment to eradicate H. pylori. The rise in non‐H. pylori‐associated ulcers and erosions continues to be reported with no apparent risk factors for these ulcers identified to date. High levels of treatmen... Helicobacter journals http://www.medworm.com/rss/comments.php?id=5209834 Thu, 01 Sep 2011 04:00:00 +0100 5209834 http://www.medworm.com/index.php?rid=5209833&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00881.x This article reviews the literature published pertaining to Helicobacter pylori eradication over the last year. The general perception among clinicians and academics engaged in research on H. pylori has been that eradication rates for first‐line therapies are falling, although some data published this year have cast doubt on this. The studies published this year have therefore focussed on developing alternative strategies for the first‐line eradication of H. pylori. In this regard, clear evidence now exists that both levofloxacin and bismuth are viable options for first‐line therapy. The sequential and “concomitant” regimes have also been studied in new settings and may have a role in future algorithms also. In addition, data have emerged that the probiotic Saccharomyces boul... Helicobacter journals http://www.medworm.com/rss/comments.php?id=5209833 Thu, 01 Sep 2011 04:00:00 +0100 5209833 http://www.medworm.com/index.php?rid=5209832&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00880.x AbstractThe validity and usefulness of the 7th edition of the UICC tumor node metastasis classification in the context of clinical management of gastric cancer are discussed. The most relevant new agent in gastric cancer therapy is trastuzumab for HER2‐positive gastric carcinomas. This marks the success of continuous effort of translational research. Trastuzumab, initially applied in palliative settings, is currently being evaluated also in neoadjuvant treatment regimens. Several new meta‐analyses support the carcinogenic effect of high salt intake and smoking in the context of Helicobacter pylori infection. Further data have become available on the efficacy of protective agents, acetyl salicylic acid/nonsteroidal anti‐inflammatory drugs, and antioxidants. In search for a successful ... Helicobacter journals http://www.medworm.com/rss/comments.php?id=5209832 Thu, 01 Sep 2011 04:00:00 +0100 5209832 http://www.medworm.com/index.php?rid=5209831&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00879.x AbstractGastric cancer (GC) is a world health burden, ranging as the second cause of cancer death worldwide. Etiologically, GC arises not only from the combined effects of environmental factors and susceptible genetic variants but also from the accumulation of genetic and epigenetic alterations. In the last years, molecular oncobiology studies brought to light a number of genes that are implicated in gastric carcinogenesis. This review is intended to focus on the recently described basic aspects that play key roles in the process of gastric carcinogenesis. Genetic variants of the genes IL‐10, IL‐17, MUC1, MUC6, DNMT3B, SMAD4, and SERPINE1 have been reported to modify the risk of developing GC. Several genes have been newly associated with gastric carcinogenesis, both through oncogenic ... Helicobacter journals http://www.medworm.com/rss/comments.php?id=5209831 Thu, 01 Sep 2011 04:00:00 +0100 5209831 http://www.medworm.com/index.php?rid=5209830&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00878.x AbstractResearch published over the past year has documented the continued decline of Helicobacter pylori‐related peptic ulcer disease and increased recognition of non‐H. pylori, non‐steroidal anti‐inflammatory drugs ulcer disease – idiopathic ulcers. Despite reduced prevalence of uncomplicated PUD, rates of ulcer complications and associated mortality remain stubbornly high. The role of H. pylori in functional dyspepsia is unclear, with some authors considering H. pylori‐associated nonulcer dyspepsia a distinct organic entity. There is increasing acceptance of an inverse relationship between H. pylori and gastroesophageal reflux disease (GERD), but little understanding of how GERD might be more common/severe in H. pylori‐negative subjects. Research has focused on factor... Helicobacter journals http://www.medworm.com/rss/comments.php?id=5209830 Thu, 01 Sep 2011 04:00:00 +0100 5209830 http://www.medworm.com/index.php?rid=5209829&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00877.x AbstractThe immune response to Helicobacter pylori entails both innate effectors and a complex mix of Th1, Th17, and Treg adaptive immune responses. The clinical outcome of infection may well depend to a large degree on the relative balance of these responses. Vaccination with a wide range of antigens, adjuvants, and delivery routes can produce statistically significant reductions in H. pylori colonization levels in mice, though rarely sterilizing immunity. Whether similar reductions in bacterial load can be achieved in humans, and whether they would be clinically significant, is still unclear. However, progress in understanding the role of Th1, Th17, and most recently Treg cells in protection against H. pylori infection provides reason for optimism. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5209829 Thu, 01 Sep 2011 04:00:00 +0100 5209829 http://www.medworm.com/index.php?rid=5209828&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00876.x AbstractHelicobacter pylori infections and clinical outcome are dependent on sophisticated interactions between the bacteria and its host. Crucial bacterial factors associated with pathogenicity comprise a type IV secretion system encoded by the cag pathogenicity island, the effector protein CagA, the vacuolating cytotoxin (VacA), peptidoglycan, lipopolysaccharide (LPS), γ‐glutamyl transpeptidase (GGT), protease HtrA, and the adhesins BabA, SabA, and others. The high number of these factors and allelic variation of the involved genes generates a highly complex scenario and reveals the difficulties in testing the contribution of each individual factor. Much effort has been put into identifying the molecular mechanisms associated with H. pylori‐associated pathogenesis using human prima... Helicobacter journals http://www.medworm.com/rss/comments.php?id=5209828 Thu, 01 Sep 2011 04:00:00 +0100 5209828 http://www.medworm.com/index.php?rid=5209827&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00875.x AbstractWhen an endoscopy is performed, it now becomes easier to observe indirect evidence of the presence of a Helicobacter pylori infection, given the progress of new methods including magnifying narrow band imaging or confocal laser endomicroscopy. Out of the biopsy‐based tests, the novel original method proposed concerned culture in a broth medium with or without antibiotics and ELISA detection of H. pylori. New stool antigen tests are still appearing with no major improvement in comparison with the monoclonal‐based tests already on the market. The combination of pepsinogen detection to H. pylori serology is now more and more evaluated to detect preneoplastic lesions. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5209827 Thu, 01 Sep 2011 04:00:00 +0100 5209827 http://www.medworm.com/index.php?rid=5209826&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00874.x AbstractThis review summarizes studies on the epidemiology and public health implications of Helicobacter pylori published in peer‐reviewed journals from April 2010 through March 2011. Prevalence rates vary widely between different geographical regions and ethnic groups. An interesting study from the USA identified the degree of African ancestry as an independent predictor of H. pylori infection. Two studies have demonstrated early childhood as the period of transmission of infection and identified an infected sibling as an important risk factor. An oral–oral route of spread has been substantiated with several studies showing the presence of H. pylori in the oral cavity. Studies have shown the presence of H. pylori in drinking water and the role of poor living conditions and sanitat... Helicobacter journals http://www.medworm.com/rss/comments.php?id=5209826 Thu, 01 Sep 2011 04:00:00 +0100 5209826 http://www.medworm.com/index.php?rid=5040622&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00869.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5040622 Wed, 20 Jul 2011 17:50:02 +0100 5040622 http://www.medworm.com/index.php?rid=5040621&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00849.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5040621 Wed, 20 Jul 2011 17:50:01 +0100 5040621 http://www.medworm.com/index.php?rid=5040620&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00843.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5040620 Wed, 20 Jul 2011 17:50:00 +0100 5040620 http://www.medworm.com/index.php?rid=5040619&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00863.x Discussion:  The 13C‐UBT performance meta‐analyses showed 1, good accuracy in all ages combined (sensitivity 95.9%, specificity 95.7%, LR+ 17.4, LR− 0.06, diagnostic odds ratio (DOR) 424.9), 2, high accuracy in children >6 years (sensitivity 96.6%, specificity 97.7%, LR+ 42.6, LR− 0.04, DOR 1042.7), 3, greater variability in accuracy estimates and on average a few percentage points lower, particularly specificity, in children ≤6 years (sensitivity 95%, specificity 93.5%, LR+ 11.7, LR− 0.12, DOR 224.8). Therefore, the meta‐analysis shows that the 13C‐UBT test is less accurate for the diagnosis of H. pylori infection in young children, but adjusting cutoff value, pretest meal, and urea dose, this accuracy can be improved. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5040619 Wed, 20 Jul 2011 17:49:59 +0100 5040619 http://www.medworm.com/index.php?rid=5040618&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00847.x Conclusions: 13C‐UBT was shown to be a reliable method for the detection of H. pylori infection in C57BL/6 mice and was even more accurate than immunohistochemistry. The use of 13C‐UBT in the mouse model of H. pylori infection can be very useful to detect the bacterium without the need to kill the animals in long‐term time course studies. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5040618 Wed, 20 Jul 2011 17:49:59 +0100 5040618 http://www.medworm.com/index.php?rid=5040617&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00850.x Conclusion:  Our results showed a significant decrease in H. pylori infection rates from children referred for upper gastrointestinal symptoms evaluation from 2002 to 2009, following the H. pylori epidemiologic trend reported in other countries. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5040617 Wed, 20 Jul 2011 17:49:58 +0100 5040617 http://www.medworm.com/index.php?rid=5040616&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00845.x Conclusion:  This assay proved to be appropriate for H. pylori clarithromycin susceptibility testing, particularly in children populations where a high prevalence of clarithromycin‐resistant strains is suspected. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5040616 Wed, 20 Jul 2011 17:49:57 +0100 5040616 http://www.medworm.com/index.php?rid=5040615&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00840.x Conclusions:  Fluoroquinolone resistance of H. pylori was caused by gyrA Asn‐87 and Asp‐91 point mutations. The Asn‐87 mutation seems to be an important determinant of failure of fluoroquinolone‐containing triple eradication therapy based on eradication results. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5040615 Wed, 20 Jul 2011 17:49:57 +0100 5040615 http://www.medworm.com/index.php?rid=5040614&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00857.x Conclusions:  Bismuth‐containing quadruple therapy remained highly effective (i.e., ≥95% PP and >90% ITT) despite reducing the duration from 14 to 10 days. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5040614 Wed, 20 Jul 2011 17:49:56 +0100 5040614 http://www.medworm.com/index.php?rid=5040613&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00844.x Conclusions:  Although PBMT7 was not inferior to PBMT14 statistically, PBMT could not demonstrate enough ITT/PP eradication rate. Therefore, it could be better to extend the duration of treatment for 2 weeks for the second‐line treatment of H. pylori in Korea. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5040613 Wed, 20 Jul 2011 17:49:55 +0100 5040613 http://www.medworm.com/index.php?rid=5040612&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00848.x Conclusions:  Fourteen‐day quadruple therapy with a combination of proton‐pump inhibitor, bismuth citrate, furazolidone, and rufloxacin is considered an effective and safe rescue therapy for H. pylori eradication after failure of standard triple treatment. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5040612 Wed, 20 Jul 2011 17:49:54 +0100 5040612 http://www.medworm.com/index.php?rid=5040611&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00851.x Conclusion:  These results support a model whereby the EPIYA motif of CagA is phosphorylated by Src family kinases in gastric epithelial cells, which initiates activation of SHP‐2. In addition, they suggest that the resultant activation of ERK pathway along with CagA‐dependent NF‐κB activation is critical for the induction of MMP‐9 secretion. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5040611 Wed, 20 Jul 2011 17:49:53 +0100 5040611 http://www.medworm.com/index.php?rid=5040610&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00852.x Conclusion/Impact:  Apparent incidence rates of H. pylori infection among adults in Western populations should be interpreted with utmost caution. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5040610 Wed, 20 Jul 2011 17:49:53 +0100 5040610 http://www.medworm.com/index.php?rid=5040609&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00846.x Conclusion: H. pylori eradication does not aggravate the clinical outcomes in terms of short‐term and long‐term posteradication occurrence of GERD. There is no association between H. pylori eradication and the development of GERD in the patients with different diseases, even those with GERD. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5040609 Wed, 20 Jul 2011 17:49:52 +0100 5040609 http://www.medworm.com/index.php?rid=5040608&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00865.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=5040608 Wed, 20 Jul 2011 17:49:51 +0100 5040608 http://www.medworm.com/index.php?rid=4832416&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00836.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4832416 Wed, 18 May 2011 17:55:23 +0100 4832416 http://www.medworm.com/index.php?rid=4832415&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00837.x Conclusion:  Children with IL‐1B‐511TT/‐31CC may have a risk to develop relatively severe gastric mucosal histological changes in South China. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4832415 Wed, 18 May 2011 17:55:22 +0100 4832415 http://www.medworm.com/index.php?rid=4832414&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00841.x Conclusions:  Although there was high bacterial resistance to metronidazole, the absence of resistance particularly to the key antibiotics used in H. pylori eradication therapy: clarithromycin and levofloxacin is reassuring to note. Continued monitoring of antibiotic resistance should be carried out. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4832414 Wed, 18 May 2011 17:55:20 +0100 4832414 http://www.medworm.com/index.php?rid=4832413&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00842.x Conclusion:  This 2‐week metronidazole‐containing second‐line therapy provides high efficacy in Japan where metronidazole resistance is rare. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4832413 Wed, 18 May 2011 17:55:19 +0100 4832413 http://www.medworm.com/index.php?rid=4832412&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00834.x Conclusion:  The sequential regimen attained significantly higher eradication rates in naïve patients than usually reported for conventional triple therapy. Sequential therapy may be an alternative first‐line therapy in eradicating H. pylori in Israel. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4832412 Wed, 18 May 2011 17:55:17 +0100 4832412 http://www.medworm.com/index.php?rid=4832411&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00823.x Conclusion:  Although LAC plus tid metronidazole regimen achieved a much better eradication rate compared with the standard LAC regimen; this is the first study that has a relatively low success with a concomitant therapy. So in areas of high resistance like Turkey, one cannot expect a high success with any clarithromycin containing regimen and those should be avoided. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4832411 Wed, 18 May 2011 17:55:16 +0100 4832411 http://www.medworm.com/index.php?rid=4832410&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00832.x Conclusions:  Increased gastric OPN expression by H. pylori infection can correlate with a more severe gastric inflammation and the presence of IM. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4832410 Wed, 18 May 2011 17:55:15 +0100 4832410 http://www.medworm.com/index.php?rid=4832409&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00833.x Conclusion:  Our findings indicate that the clinicopathological characteristics of gastric cancers detected after H. pylori eradication are different from those of gastric cancers in patients with persistent H. pylori infection. H. pylori eradication may suppress intestinalization during the development of gastric cancer. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4832409 Wed, 18 May 2011 17:55:12 +0100 4832409 http://www.medworm.com/index.php?rid=4832408&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00831.x Conclusions:  In this study, we identified antigens that are common and specific to the H. pylori cagPAI+ and cagPAI− strains. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4832408 Wed, 18 May 2011 17:55:10 +0100 4832408 http://www.medworm.com/index.php?rid=4832407&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00824.x Conclusion:  A subset of proteins is involved in the ATR and confer a negative ATR phenotype. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4832407 Wed, 18 May 2011 17:55:09 +0100 4832407 http://www.medworm.com/index.php?rid=4832406&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00838.x Conclusions:  Genome‐wide methylation profiles showed a number of genes differentially methylated by H. pylori infection. Methylation profiles in noncancerous gastric mucosae from the patients with gastric cancer can be affected by H. pylori‐induced gastritis. Differentially methylated CpG sites in this study needs to be validated in a larger population using quantitative methylation‐specific PCR method. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4832406 Wed, 18 May 2011 17:55:08 +0100 4832406 http://www.medworm.com/index.php?rid=4832405&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00839.x Conclusion:  These data suggest that there are compensatory mechanisms for protection against H. pylori and for neutrophil recruitment in the absence of an IL‐17A‐CXC chemokine pathway. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4832405 Wed, 18 May 2011 17:55:07 +0100 4832405 http://www.medworm.com/index.php?rid=4832404&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00853.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4832404 Wed, 18 May 2011 17:55:06 +0100 4832404 http://www.medworm.com/index.php?rid=4596133&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00825.x Conclusions:  This study showed evidence of the variability of antigenic pattern among H. pylori strains. We believe that this fact contributes to the failure of anti‐H. pylori vaccines and the low accuracy of serological tests based on a low number of proteins or antigens of only one strain. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4596133 Wed, 16 Mar 2011 17:15:27 +0100 4596133 http://www.medworm.com/index.php?rid=4596132&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00829.x Conclusions:  Extending sequential therapy to 14 days did not result in improving the treatment outcome to 95% or greater. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4596132 Wed, 16 Mar 2011 17:15:27 +0100 4596132 http://www.medworm.com/index.php?rid=4596131&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00828.x Conclusions:  Fourteen‐day hybrid sequential–concomitant therapy achieved >95%H. pylori eradication (Grade A result). Further studies are needed 1, in regions with different patterns and frequencies of resistance to confirm these findings, and 2, to examine whether Grade A success is maintained with hybrid therapy shorter than 14 days. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4596131 Wed, 16 Mar 2011 17:15:26 +0100 4596131 http://www.medworm.com/index.php?rid=4596130&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00826.x Conclusion:  Moxifloxacin‐containing triple regimen is more effective and better tolerated than the bismuth‐containing quadruple therapy in the second‐line treatment of H. pylori infection. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4596130 Wed, 16 Mar 2011 17:15:26 +0100 4596130 http://www.medworm.com/index.php?rid=4596129&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00830.x Conclusion:  In hypothyroid cases, H. pylori gastritis may be responsible for an inadequate response to the treatment. H. pylori eradication in the cases receiving high doses of thyroxine has a risk for thyrotoxicosis. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4596129 Wed, 16 Mar 2011 17:15:25 +0100 4596129 http://www.medworm.com/index.php?rid=4596128&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00820.x Conclusions:  The disk diffusion method is equivalent to the E‐test method for testing levofloxacin susceptibility of H. pylori strains; it is more practical and inexpensive, and it is suitable for the analysis of a small number of isolates compared with the E‐test method. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4596128 Wed, 16 Mar 2011 17:15:25 +0100 4596128 http://www.medworm.com/index.php?rid=4596127&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00819.x Conclusions:  The proposed technique allows detection of very low quantities of H. pylori DNA in biological samples. In laboratory animal models, detailed monitoring of infection and complete clearance of infection can be demonstrated thanks to the low detection limit. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4596127 Wed, 16 Mar 2011 17:15:24 +0100 4596127 http://www.medworm.com/index.php?rid=4596126&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00827.x Conclusion: H. pylori infection is consistently high in Russian and eastern Siberian populations; ethnicities with similar prevalence of CagA+ve status had different prevalence of IM and incidence of GC. As expected, IM prevalence correlated with the incidence of GC. Host‐related and/or environmental factors may explain discrepancies between H. pylori status, the prevalence of IM, and the incidence of GC. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4596126 Wed, 16 Mar 2011 17:15:24 +0100 4596126 http://www.medworm.com/index.php?rid=4596125&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00821.x Conclusion:  XRCC1 codon 399 Gln/Gln genotype is associated with reduced susceptibility to CIHM especially DAP‐kinase. GSTM1 null genotype may increase the susceptibility to CIHM especially in older patients. Genetic factors, related to DNA repair or xenobiotic pathways may have a role in CIHM‐related gastric carcinogenesis. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4596125 Wed, 16 Mar 2011 17:15:23 +0100 4596125 http://www.medworm.com/index.php?rid=4596124&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00815.x Conclusions:  This in vitro study shows that mannose‐related proteoglycans (proteomannans) are involved in the process of H. pylori biofilm formation while the presence of upregulated NapA in the biofilm implies the potency to increase adhesiveness of H. pylori biofilm. Being a complex matrix of proteins and carbohydrates, which are probably interdependent, the H. pylori biofilm could possibly offer a protective haven for the survival of this gastric bacterial pathogen in the extragastric environments. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4596124 Wed, 16 Mar 2011 17:15:22 +0100 4596124 http://www.medworm.com/index.php?rid=4596123&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00822.x Conclusions:  Although data seem to indicate a potential association between H. pylori infection and IR, further studies are needed to strengthen this association and to clarify whether there is a causative link between them. If a causal link is confirmed in the future, this may have a major impact on the pathophysiology and management of IR syndrome, including type 2 diabetes mellitus and nonalcoholic fatty liver disease. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4596123 Wed, 16 Mar 2011 17:15:22 +0100 4596123 http://www.medworm.com/index.php?rid=4596122&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00835.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4596122 Wed, 16 Mar 2011 17:15:21 +0100 4596122 http://www.medworm.com/index.php?rid=4356640&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00811.x Conclusions:  When H. pylori infect in stomach, it may reduce the severity of inflammation. However, when colonizes in esophagus, H. pylori increases the severity of esophageal inflammation and the incidence of BE and EA. Celecoxib administration attenuates the incidence of EA by inhibiting COX‐2 expression. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4356640 Mon, 17 Jan 2011 19:22:21 +0100 4356640 http://www.medworm.com/index.php?rid=4356639&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00814.x Conclusion:  We suggest that H. pylori may impair growth significantly only in susceptible children where unfavorable socioeconomic conditions facilitate its action, probably through mechanisms, at least in part, involving growth‐related molecules. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4356639 Mon, 17 Jan 2011 19:22:21 +0100 4356639 http://www.medworm.com/index.php?rid=4356638&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00817.x Conclusion:  The MTL regimen failed to achieve the recommended eradication rates and had higher adverse effect rate. Hence, MTL regimen does not seem to be a suitable choice as a first‐line Hp eradication therapy. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4356638 Mon, 17 Jan 2011 19:22:20 +0100 4356638 http://www.medworm.com/index.php?rid=4356637&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00816.x Conclusions:  The resistance rates of the antibiotics used in primary treatment of H. pylori infections in Malaysia are low, and multi‐antibiotic‐resistant strains are uncommon. Infections with mixed populations of metronidazole‐sensitive and ‐resistant strains were also observed. However, the high metronidazole MIC values seen among the metronidazole‐resistant strains are a cause for concern. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4356637 Mon, 17 Jan 2011 19:22:19 +0100 4356637 http://www.medworm.com/index.php?rid=4356636&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00813.x Conclusions:  Using of AhpC antigen for diagnosis of H. pylori infection is a useful noninvasive method, accurate in adolescents and children, and can be used for the development of a stool antigen detection kit for H. pylori. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4356636 Mon, 17 Jan 2011 19:22:18 +0100 4356636 http://www.medworm.com/index.php?rid=4356635&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00807.x Conclusions:  None of the patients with H. pylori‐positive stage IE1 gastric MALT lymphoma who experienced tumor recurrence after CR with successful H. pylori eradication showed recurrence at extragastric sites, including lymph nodes without gastric mucosal lesion. These findings indicate that endoscopic biopsies without abdominal CT scans are sufficient to detect recurrence in these patients. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4356635 Mon, 17 Jan 2011 19:22:17 +0100 4356635 http://www.medworm.com/index.php?rid=4356634&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00809.x Conclusion:  In H. pylori‐negative children, gastritis was associated with an increased percentage of activated NK and T cells, and intermediate‐differentiated peripheral blood CD4+ T cells, which was more pronounced in H. pylori‐positive children who also showed an increased B‐cell response. However, increased inflammation was only associated with the elevation of CD4+ T‐cell percentage in H. pylori‐positive children as well as B‐cell percentage in H. pylori‐negative children with gastritis. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4356634 Mon, 17 Jan 2011 19:22:16 +0100 4356634 http://www.medworm.com/index.php?rid=4356633&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00804.x Conclusion:  Topographically, the urease activity in body was much higher than in antrum. The expression level of amiE was higher in the gastric body compared with the antrum. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4356633 Mon, 17 Jan 2011 19:22:16 +0100 4356633 http://www.medworm.com/index.php?rid=4356632&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00810.x Conclusions:  The presence of lactobacilli in the stomach did not select for different mucin binding properties of H. pylori, and Lactobacillus sp. did neither compete for binding sites nor inhibit the growth of co‐isolated H. pylori. The effects of human gastric mucins on H. pylori proliferation vary between strains, and the host–bacteria interaction in the mucus niche thus depends on both the H. pylori strain and the microenvironment provided by the host mucins. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4356632 Mon, 17 Jan 2011 19:22:15 +0100 4356632 http://www.medworm.com/index.php?rid=4356631&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00812.x Conclusion:  IL‐17 plays an important role in H. pylori‐related gastritis and in the reduction of Helicobacter infection in mice following immunization. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4356631 Mon, 17 Jan 2011 19:22:14 +0100 4356631 http://www.medworm.com/index.php?rid=4356630&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2011.00818.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4356630 Mon, 17 Jan 2011 19:22:13 +0100 4356630 http://www.medworm.com/index.php?rid=4165099&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00802.x Conclusions:  The association between the Helicobacter pylori and Graves’ disease suggests a possible role of this bacterium in the onset and/or the maintenance of the disease. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4165099 Mon, 15 Nov 2010 08:25:38 +0100 4165099 http://www.medworm.com/index.php?rid=4165098&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00792.x Conclusions:  The higher prevalence of Helicobacteraceae DNA in Crohn’s disease patients would suggest that members of this family may be involved in this disease. In addition, phylogenetic analysis of H. pylori strains showed that extragastric sequences clustered together, indicating that different H. pylori strains may adapt to colonize extragastric niches. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4165098 Mon, 15 Nov 2010 08:25:36 +0100 4165098 http://www.medworm.com/index.php?rid=4165097&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00801.x Conclusions:  HEV‐like vessels expressing GlcNAc6ST‐1‐mediated L‐selectin ligand carbohydrate and MAdCAM‐1 may play a crucial role in the pathogenesis of “Candidatus Helicobacter heilmannii”‐induced chronic gastritis and MALT lymphoma. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4165097 Mon, 15 Nov 2010 08:25:34 +0100 4165097 http://www.medworm.com/index.php?rid=4165096&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00800.x Conclusion:  The prevalence of H. pylori in this group of adolescents was high. However, there was no correlation between H. pylori and HAV infection rates. Hence, factors contributing to the transmission source and route seem to be different. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4165096 Mon, 15 Nov 2010 08:25:33 +0100 4165096 http://www.medworm.com/index.php?rid=4165094&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00806.x Conclusions:  The rs2910164 (G>C) SNP in the miR‐146a is associated with susceptibility to GC. In addition, the rs11614913 (C>T) SNP in the miR‐196a2 is associated with the degree of H. pylori‐induced mononuclear cell infiltration. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4165094 Mon, 15 Nov 2010 08:25:31 +0100 4165094 http://www.medworm.com/index.php?rid=4165093&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00805.x Conclusions:  A DU is not rare in patients with GC in a high‐risk region of GC. Patients with a DU with chronic corpus gastritis and IM have an increased risk of GC, thus those patients should be followed up for GC development. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4165093 Mon, 15 Nov 2010 08:25:30 +0100 4165093 http://www.medworm.com/index.php?rid=4165092&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00803.x Conclusion:  Long‐standing statin therapy may reduce the severity of chronic gastritis. Mild increased CRP levels in absence of obvious source can predict the severity of chronic gastritis. Further researches are needed to assess the effect of statin in chronic gastritis. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4165092 Mon, 15 Nov 2010 08:25:29 +0100 4165092 http://www.medworm.com/index.php?rid=4165091&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00795.x Conclusions:  The prevalence of H. pylori antibiotic resistance to metronidazole and clarithromycin was high in Iran consistent with the reported low success rates for H. pylori treatment in this country. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4165091 Mon, 15 Nov 2010 08:25:27 +0100 4165091 http://www.medworm.com/index.php?rid=4165090&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00798.x Conclusion:  Furazolidone can replace clarithromycin in H. pylori eradication regimens because of lack of development of resistance and very low cost. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4165090 Mon, 15 Nov 2010 08:25:26 +0100 4165090 http://www.medworm.com/index.php?rid=4165089&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00791.x Conclusion:  The transmission of H. pylori occurs from infected mothers to their offspring and among siblings, notably from younger siblings to the older ones. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4165089 Mon, 15 Nov 2010 08:25:25 +0100 4165089 http://www.medworm.com/index.php?rid=4165086&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00799.x AbstractA study conducted by the Japan Gast Study Group showed that eradication of Helicobacter pylori reduced the risk of gastric cancer by about one‐third. However, it did not completely prevent the onset of latent gastric cancer among those at high risk (i.e., with atrophic gastritis). To prevent deaths from gastric cancer, it is necessary to eradicate H. pylori infection. We propose a program of risk stratification based on the presence of H. pylori infection with or without atrophic gastritis followed by targeted interventions. Those at no risk for gastric cancer (no H. pylori, no atrophic gastritis) need no therapy or follow‐up. Those at low risk (H. pylori infected, nonatrophic gastritis) need only H. pylori eradication therapy. The smaller groups at high or very high risk ... Helicobacter journals http://www.medworm.com/rss/comments.php?id=4165086 Mon, 15 Nov 2010 08:25:13 +0100 4165086 http://www.medworm.com/index.php?rid=4165085&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00808.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=4165085 Mon, 15 Nov 2010 08:25:00 +0100 4165085 http://www.medworm.com/index.php?rid=3937185&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00797.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3937185 Tue, 07 Sep 2010 06:04:53 +0100 3937185 http://www.medworm.com/index.php?rid=3937184&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00785.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3937184 Tue, 07 Sep 2010 06:04:53 +0100 3937184 http://www.medworm.com/index.php?rid=3937183&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00769.x Abstract (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3937183 Tue, 07 Sep 2010 06:04:52 +0100 3937183 http://www.medworm.com/index.php?rid=3937182&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00794.x Abstract (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3937182 Tue, 07 Sep 2010 06:04:52 +0100 3937182 http://www.medworm.com/index.php?rid=3937181&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00793.x Abstract (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3937181 Tue, 07 Sep 2010 06:04:51 +0100 3937181 http://www.medworm.com/index.php?rid=3937180&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00788.x Abstract (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3937180 Tue, 07 Sep 2010 06:04:51 +0100 3937180 http://www.medworm.com/index.php?rid=3937179&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00796.x Abstract (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3937179 Tue, 07 Sep 2010 06:04:50 +0100 3937179 http://www.medworm.com/index.php?rid=3937178&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00787.x Abstract (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3937178 Tue, 07 Sep 2010 06:04:50 +0100 3937178 http://www.medworm.com/index.php?rid=3937177&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00786.x Abstract (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3937177 Tue, 07 Sep 2010 06:04:49 +0100 3937177 http://www.medworm.com/index.php?rid=3937176&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00789.x Abstract (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3937176 Tue, 07 Sep 2010 06:04:49 +0100 3937176 http://www.medworm.com/index.php?rid=3937175&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00790.x Abstract (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3937175 Tue, 07 Sep 2010 06:04:49 +0100 3937175 http://www.medworm.com/index.php?rid=3937174&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00770.x Abstract (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3937174 Tue, 07 Sep 2010 06:04:48 +0100 3937174 http://www.medworm.com/index.php?rid=3851091&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00767.x Abstract (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3851091 Sat, 31 Jul 2010 23:00:00 +0100 3851091 http://www.medworm.com/index.php?rid=3851090&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00768.x Abstract (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3851090 Sat, 31 Jul 2010 23:00:00 +0100 3851090 http://www.medworm.com/index.php?rid=3851089&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00760.x Abstract (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3851089 Sat, 31 Jul 2010 23:00:00 +0100 3851089 http://www.medworm.com/index.php?rid=3851088&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00762.x Abstract (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3851088 Sat, 31 Jul 2010 23:00:00 +0100 3851088 http://www.medworm.com/index.php?rid=3755682&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00771.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3755682 Thu, 15 Jul 2010 23:00:00 +0100 3755682 http://www.medworm.com/index.php?rid=3755681&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00764.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3755681 Thu, 15 Jul 2010 23:00:00 +0100 3755681 http://www.medworm.com/index.php?rid=3755680&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00763.x Conclusions: The sequential statistical approach increased the planktonic H. pylori cell culture. The final culture media and conditions were: Brain Heart Infusion, blood agarose (1.5% w/v), lamb's blood (3.18% v/v), DENT (0.11% v/v), and Vitox (0.52% v/v) at 60 rpm and 37 °C with filtered CO2 (5% v/v) bubbled directly into the culture media in a final volume of 76.22 mL. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3755680 Thu, 15 Jul 2010 23:00:00 +0100 3755680 http://www.medworm.com/index.php?rid=3755679&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00767.x Conclusions: Thin-layer liquid culture technique is feasible, and can serve as a versatile liquid culture technique for investigating bacterial properties of H. pylori. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3755679 Thu, 15 Jul 2010 23:00:00 +0100 3755679 http://www.medworm.com/index.php?rid=3755678&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00768.x Conclusion: Helicobacter is an arbiter of progression, independent of infection-load. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3755678 Thu, 15 Jul 2010 23:00:00 +0100 3755678 http://www.medworm.com/index.php?rid=3755677&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00766.x Conclusion: Our data show that H. pylori infection in children from a major Brazilian city is associated with variables indicative of a crowded environment and deficient sanitation/habitation conditions, leading to the conclusion that improvements in hygiene and social conditions may protect children against this infection. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3755677 Thu, 15 Jul 2010 23:00:00 +0100 3755677 http://www.medworm.com/index.php?rid=3755676&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00761.x Conclusions: In quadruple therapy, rabeprazole-based regimens had better efficacy than esomeprazole-based regimens. CYP2C19 polymorphism also played an important role in quadruple therapy. It seems advisable to change PPI to rabeprazole in second-line quadruple therapy. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3755676 Thu, 15 Jul 2010 23:00:00 +0100 3755676 http://www.medworm.com/index.php?rid=3755675&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00760.x Conclusions: At surveillance endoscopies, both targeted and non-targeted biopsies are required for an appropriate diagnosis of (pre-)malignant gastric lesions. Non-targeted biopsies should be obtained in particular from the antrum, angulus and lesser curvature of the corpus. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3755675 Thu, 15 Jul 2010 23:00:00 +0100 3755675 http://www.medworm.com/index.php?rid=3755674&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00765.x Conclusions: Mucin expression and glycosylation is similar in children and adults. However, in contrast to adults, pediatric H. pylori infection is not accompanied by aberrant expression of MUC6 or MUC2. Furthermore, the lower H. pylori density in Leb positive children indicates that H. pylori is suppressed in the presence of gastric mucins decorated with Leb, the binding site of the H. pylori BabA adhesin. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3755674 Thu, 15 Jul 2010 23:00:00 +0100 3755674 http://www.medworm.com/index.php?rid=3755673&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00762.x Conclusions: Duodenal ulcer is more closely related to H. pylori infection than GU in NSAID users. H. pylori eradication is recommended for primary prevention of GU and DU in patients requiring NSAID therapy. PPI therapy is mandatory for secondary prevention of gastroduodenal ulcers, and appears to further reduce the risk of ulcer relapse in the presence of H. pylori. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3755673 Mon, 31 May 2010 23:00:00 +0100 3755673 http://www.medworm.com/index.php?rid=3539945&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00758.x Conclusions: Addition bismuth and prolonging treatment duration can overcome H. pylori resistance to clarithromycin and decrease the bacterial load. Fourteen-day triple therapy-based, bismuth-containing quadruple therapy achieved ITT success rate 93% and could be recommended as the first line eradication regimen. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3539945 Thu, 06 May 2010 23:00:00 +0100 3539945 http://www.medworm.com/index.php?rid=3539944&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00756.x Conclusions: CLO-test had lower sensitivity and comparable specificity with histology. Both tests should be performed concurrently to accurately diagnose H. pylori infection in children. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3539944 Thu, 06 May 2010 23:00:00 +0100 3539944 http://www.medworm.com/index.php?rid=3539943&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00752.x Conclusions: According to our simulation, the relatively high risk of cancer in patients with IM and the substantial efficacy of endoscopic surveillance in reducing cancer-related mortality would support the cost-effectiveness of an endoscopic surveillance program in patients with IM. Further research is needed before implementing it in the clinical practice. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3539943 Thu, 06 May 2010 23:00:00 +0100 3539943 http://www.medworm.com/index.php?rid=3539942&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00753.x Conclusions: In the last decade, the rate of primary resistance of H. pylori to clarithromycin continued to rise. No significant change was found regarding primary resistance to metronidazole or dual resistance to metronidazole and clarithromycin, respectively. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3539942 Thu, 06 May 2010 23:00:00 +0100 3539942 http://www.medworm.com/index.php?rid=3539941&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00751.x Conclusion: This study suggests that supplementation with S. boulardii could be effective for improving HP eradication rates by reducing side effects thus helping completion of eradication therapy. However, there were no significant effects on HP eradication rates associated with the addition of mucoprotective agents to probiotics and triple therapy. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3539941 Thu, 06 May 2010 23:00:00 +0100 3539941 http://www.medworm.com/index.php?rid=3539940&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00757.x Conclusion: All monoclonal fecal tests in this series presented similar performance in the post-treatment setting. A negative test after treatment adequately predicted cure of the infection. However, nearly a third of tests were false positive, showing a poor predictive yield for persistent infection. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3539940 Thu, 06 May 2010 23:00:00 +0100 3539940 http://www.medworm.com/index.php?rid=3539939&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00754.x Conclusions: The use of recombinant protein technology allowed obtaining pure CagA antigen, thus providing new perspectives for development of immunodiagnostic reagents. The set of monoclonal antibodies is a valuable tool for determination of CagA-status of H. pylori infection and for the investigation of cytotoxin molecule as well. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3539939 Thu, 06 May 2010 23:00:00 +0100 3539939 http://www.medworm.com/index.php?rid=3539938&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00755.x Conclusion: It was suggested that H. pylori GGT is constitutively expressed under various conditions. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3539938 Thu, 06 May 2010 23:00:00 +0100 3539938 http://www.medworm.com/index.php?rid=3539937&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00750.x Conclusions: While immune sera appeared to have a slight positive effect on bacterial uptake, both serum-treated and control H. pylori were not eliminated by macrophages. Furthermore, the same disruptions to phagosome maturation were observed for both serum-treated and control H. pylori. We conclude that to eliminate H. pylori, a strategy is required to restore the normal process of phagosome maturation and enable effective macrophage killing of H. pylori, following a host immune response. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3539937 Thu, 06 May 2010 23:00:00 +0100 3539937 http://www.medworm.com/index.php?rid=3539936&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2010.00759.x Several bacterial pathogens inject virulence proteins into host target cells that are substrates of eukaryotic tyrosine kinases. One of the key examples is the Helicobacter pylori CagA effector protein which is translocated by a type-IV secretion system. Injected CagA becomes tyrosine-phosphorylated on EPIYA sequence motifs by Src and Abl family kinases. CagA then binds to and activates/inactivates multiple signaling proteins in a phosphorylation-dependent and phosphorylation-independent manner. A recent proteomic screen systematically identified eukaryotic binding partners of the EPIYA phosphorylation sites of CagA and similar sites in other bacterial effectors by high-resolution mass spectrometry. Individual phosphorylation sites recruited a surprisingly high number of interaction partne... Helicobacter journals http://www.medworm.com/rss/comments.php?id=3539936 Wed, 31 Mar 2010 23:00:00 +0100 3539936 http://www.medworm.com/index.php?rid=3324336&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00743.x Conclusion: Both in vitro and in vivo studies provide evidence that probiotics may represent a novel approach to the management of H. pylori infection. (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3324336 Wed, 03 Mar 2010 14:26:27 +0100 3324336 http://www.medworm.com/index.php?rid=3324346&cid=s_30385_17_f&fid=30385&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1523-5378.2009.00742.x (Source: Helicobacter) Helicobacter journals http://www.medworm.com/rss/comments.php?id=3324346 Wed, 03 Mar 2010 00:00:00 +0100 3324346