MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Hepatology International' source. Sat, 20 Mar 2010 14:27:49 +0100 http://www.medworm.com/index.php?rid=3360897&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5721193537481578%2F Content Type Journal ArticleDOI 10.1007/s12072-010-9174-6 Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 Journal Volume Volume 4 Journal Issue Volume 4, Supplement 1 / March, 2010 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=3360897 Thu, 11 Mar 2010 18:01:44 +0100 3360897 http://www.medworm.com/index.php?rid=3360898&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu47k6569782j1400%2F Content Type Journal ArticleDOI 10.1007/s12072-010-9175-5 Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 Journal Volume Volume 4 Journal Issue Volume 4, Supplement 1 / March, 2010 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=3360898 Thu, 11 Mar 2010 18:01:43 +0100 3360898 http://www.medworm.com/index.php?rid=3360899&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3p5173131v833142%2F Content Type Journal ArticleDOI 10.1007/s12072-010-9169-3 Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 Journal Volume Volume 4 Journal Issue Volume 4, Number 1 / March, 2010 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=3360899 Thu, 11 Mar 2010 07:40:57 +0100 3360899 http://www.medworm.com/index.php?rid=3360900&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa8v6251631713675%2F Content Type Journal ArticleDOI 10.1007/s12072-010-9172-8 Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 Journal Volume Volume 4 Journal Issue Volume 4, Number 1 / March, 2010 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=3360900 Thu, 11 Mar 2010 07:40:33 +0100 3360900 http://www.medworm.com/index.php?rid=3360901&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Frx2m87141273x821%2F Content Type Journal ArticleDOI 10.1007/s12072-010-9167-5 Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 Journal Volume Volume 4 Journal Issue Volume 4, Number 1 / March, 2010 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=3360901 Thu, 11 Mar 2010 07:40:28 +0100 3360901 http://www.medworm.com/index.php?rid=3360902&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F962ku286l257655j%2F Content Type Journal ArticleDOI 10.1007/s12072-010-9168-4 Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 Journal Volume Volume 4 Journal Issue Volume 4, Number 1 / March, 2010 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=3360902 Thu, 11 Mar 2010 07:40:22 +0100 3360902 http://www.medworm.com/index.php?rid=3308764&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr03tw82821858153%2F Content Type Journal ArticleDOI 10.1007/s12072-010-9173-7 Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=3308764 Wed, 24 Feb 2010 06:55:39 +0100 3308764 http://www.medworm.com/index.php?rid=3304284&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv1200214268188t5%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s12072-010-9171-9Authors Levent Filik, Ankara Research Hospital Gastroenterology Division Altindag 06600 Ankara Turkey Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=3304284 Tue, 23 Feb 2010 08:03:56 +0100 3304284 http://www.medworm.com/index.php?rid=3296180&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq36k81lh8275317q%2F Abstract  Recent guidelines of the American Association for the Study of Liver Diseases, the European Association for the Study of the Liver, and the Asian Pacific Association for the Study of the Liver 2008 update of the “Asian-Pacific consensus statement on the management of chronic hepatitis B” offer comprehensive recommendations for the general management of chronic hepatitis B (CHB). These recommendations highlight preferred approaches to the prevention, diagnosis, and treatment of CHB. Nonetheless, the results of recent studies have led to an improved understanding of the disease and a belief that current recommendations on specific therapeutic considerations, including CHB treatment initiation and cessation criteria, particularly in patient populations with speci... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3296180 Sat, 20 Feb 2010 06:57:30 +0100 3296180 http://www.medworm.com/index.php?rid=3256610&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fpv87u84174l10138%2F Conclusions  Long-term entecavir treatment of lamivudine-refractory CHB resulted in virologic suppression, ALT normalization, and improvements in liver histology. Resistance was consistent with that observed in worldwide studies. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-009-9162-xAuthors Yoshiyasu Karino, Sapporo Kosei General Hospital Department of Gastroenterology North 3, East 8, Chuo-ku Sapporo JapanJoji Toyota, Sapporo Kosei General Hospital Department of Gastroenterology North 3, East 8, Chuo-ku Sapporo JapanHiromitsu Kumada, Toranomon Hospital Department of Hepatology Tokyo JapanYoshiaki Katano, Nagoya University Department of Gastroenterology, Graduate School of Medicine Aichi JapanNamiki Izumi, Musashino Red Cross Hospital Departm... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3256610 Sat, 06 Feb 2010 08:23:35 +0100 3256610 http://www.medworm.com/index.php?rid=3241423&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp44t448712141421%2F Conclusions   Following hepatitis E epidemics, there is a gradual loss of antibodies in the community over the decades and poor exposure to HEV infection in the cohort of population born during the interepidemic period. The next epidemic occurs when antibody levels fall to critically low levels and there is associated gross fecal contamination of water resources. During epidemic, persons of all age groups are exposed to infection, with predominant anicteric disease in children. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-009-9159-5Authors Mehnaaz Sultan Khuroo, Sher-i-Kashmir Institute of Medical Sciences Department of Pathology Soura 190 001 Kashmir IndiaMohammad Sultan Khuroo, Digestive Disease Centre, Dr. Khuroo’s Medical Clinic Srinag... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3241423 Tue, 02 Feb 2010 17:55:53 +0100 3241423 http://www.medworm.com/index.php?rid=3229156&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fkp74364h7135786u%2F Conclusions  The prevalence of DVT in patients with liver cirrhosis was 4.7%, and Deep vein thrombosis is not a rare condition in cirrhotic patients with coagulopathy and warrants further studies on the mechanisms and prevention. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-010-9166-6Authors Cosmas Rinaldi A. Lesmana, University of Indonesia Department of Internal Medicine Jl. Diponegoro No. 71 Jakarta 10430 IndonesiaSri Inggriani, Radiology Unit, Medistra Hospital Jakarta IndonesiaLidwina Cahyadinata, Digestive Disease Centre, Medistra Hospital Jakarta IndonesiaLaurentius A. Lesmana, Digestive Disease Centre, Medistra Hospital Jakarta Indonesia Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatolog... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3229156 Sat, 30 Jan 2010 18:16:12 +0100 3229156 http://www.medworm.com/index.php?rid=3224089&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4382368112pr7276%2F Conclusion  Although recent progress in adjuvant therapy should be the key to a good prognosis, we believe that surgical resection may bring some hope of long-term survival for judiciously selected patients with hepatic metastases from gastric cancer. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-009-9161-yAuthors Hironori Tsujimoto, National Defense Medical College Department of Surgery 3-2 Namiki Tokorozawa 359-8513 JapanTakashi Ichikura, National Defense Medical College Department of Surgery 3-2 Namiki Tokorozawa 359-8513 JapanSatoshi Ono, National Defense Medical College Department of Surgery 3-2 Namiki Tokorozawa 359-8513 JapanHidekazu Sugasawa, National Defense Medical College Department of Surgery 3-2 Namiki Tokorozawa 359-8513 JapanShui... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3224089 Thu, 28 Jan 2010 18:05:10 +0100 3224089 http://www.medworm.com/index.php?rid=3224090&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft04j111291225737%2F Abstract Introduction  With the recent epidemic in childhood obesity, nonalcoholic fatty liver disease (NAFLD) has become an emerging problem and a common cause of chronic liver disease in children. Methods  In this review, the most recent insights on the pathogenesis, diagnosis, natural history, and treatment of NAFLD in children are discussed. Content Type Journal ArticleCategory Review ArticleDOI 10.1007/s12072-009-9160-zAuthors Ruth M. L. De Bruyne, University Hospital Ghent Department of Paediatric Gastroenterology, Hepatology and Nutrition De Pintelaan 185 9000 Ghent BelgiumEmer Fitzpatrick, King’s College Hospital Paediatric Liver, GI and Nutrition Centre, King’s College London School of Medicine London SE59RS UKAnil Dhawan, King’s Colleg... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3224090 Thu, 28 Jan 2010 18:05:07 +0100 3224090 http://www.medworm.com/index.php?rid=3224091&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa764468124u1u46u%2F Conclusions  The loss or abnormal protein downregulation and the promoter hypermethylation of RASSF1A could play important roles in the tumorigenesis development and metastases of HCC. The detection of the promoter hypermethylation of RASSF1A in serum DNA could be a valuable biomarker for early-stage diagnosis in populations at high risk of HCC. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-010-9164-8Authors Lang Hu, Guangxi Medical University Department of Epidemiology Nanning 530021 Guangxi Zhuang Autonomous Region People’s Republic of ChinaGang Chen, Guangxi Medical University Department of Pathology Shuangyong Road Nanning 530021 Guangxi Zhuang Autonomous Region People’s Republic of ChinaHongping Yu, Guangxi Medical University Departme... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3224091 Thu, 28 Jan 2010 18:05:06 +0100 3224091 http://www.medworm.com/index.php?rid=3122799&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2q5004nn44684375%2F Conclusion  The data supports the concept of heterogeneity of HCC. The three factors, bilirubin, AFP, and PVT predominate in prognosis. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-009-9157-7Authors Brian I. Carr, Thomas Jefferson University Liver Tumor Program, Kimmel Cancer Center Bluemle Building, Room 1002, 233 S. 10th Street Philadelphia 19107 PA USAPetr Pancoska, University of Pittsburgh Center for Clinical Pharmacology Philadelphia USARobert A. Branch, University of Pittsburgh Center for Clinical Pharmacology Philadelphia USA Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=3122799 Thu, 24 Dec 2009 19:49:31 +0100 3122799 http://www.medworm.com/index.php?rid=3041539&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg125306x138g7488%2F Abstract  Reactive oxygen and nitrogen species (ROS and RNS) are produced by metabolism of normal cells. However, in liver diseases, redox is increased thereby damaging the hepatic tissue; the capability of ethanol to increase both ROS/RNS and peroxidation of lipids, DNA, and proteins was demonstrated in a variety of systems, cells, and species, including humans. ROS/RNS can activate hepatic stellate cells, which are characterized by the enhanced production of extracellular matrix and accelerated proliferation. Cross-talk between parenchymal and nonparenchymal cells is one of the most important events in liver injury and fibrogenesis; ROS play an important role in fibrogenesis throughout increasing platelet-derived growth factor. Most hepatocellular carcinomas occur in cirr... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3041539 Thu, 26 Nov 2009 08:15:34 +0100 3041539 http://www.medworm.com/index.php?rid=2968902&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2735172n448160l0%2F Conclusion  Patients with NAFLD have higher AFP levels than those without fatty liver changes. AFP levels rise as grade of liver steatosis increases. NAFLD should be among the differential diagnosis of elevated serum AFP levels. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-009-9156-8Authors Ayşegül Babalı, Ankara Education and Research Hospital Department of Gastroenterology Ankara TurkeyErman Çakal, Dışkapı Education and Research Hospital Department of Endocrinology Ankara TurkeyTuğrul Purnak, Ankara Numune Education and Research Hospital Department of Gastroenterology Ankara Turkeyİbrahim Bıyıkoğlu, Ankara Education and Research Hospital Department of Gastroenterology Ankara TurkeyBaşak Çakal, Ankara Education and Research Hosp... Hepatology International journals http://www.medworm.com/rss/comments.php?id=2968902 Wed, 04 Nov 2009 18:54:34 +0100 2968902 http://www.medworm.com/index.php?rid=2921805&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv44436l0243v5236%2F Conclusions  UDCA monotherapy is effective for some Japanese AIH patients; however, UDCA monotherapy for patients with either high-grade inflammatory activity or poor residual capacity of liver function is not recommended because they may reach liver failure before achievement of remission. Meanwhile, additional use of UDCA during the taper of corticosteroids may be effective for the prevention of early relapse. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-009-9155-9Authors Yasuhiro Miyake, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Department of Molecular Hepatology Okayama JapanYoshiaki Iwasaki, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Department of Gas... Hepatology International journals http://www.medworm.com/rss/comments.php?id=2921805 Wed, 21 Oct 2009 22:21:55 +0100 2921805 http://www.medworm.com/index.php?rid=2833377&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa13r0xk225jq8732%2F Content Type Journal ArticleCategory CME InformationDOI 10.1007/s12072-009-9152-z Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=2833377 Tue, 22 Sep 2009 15:41:01 +0100 2833377 http://www.medworm.com/index.php?rid=2833378&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F156g6582r7786w22%2F Content Type Journal ArticleCategory CME Post TestDOI 10.1007/s12072-009-9153-y Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=2833378 Tue, 22 Sep 2009 15:40:59 +0100 2833378 http://www.medworm.com/index.php?rid=2810984&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fhpr1653m07t232j0%2F Abstract  Chronic hepatitis B (CHB) remains a serious clinical problem worldwide. Advances in molecular technology have enabled the development of sensitive assays for the detection and quantification of hepatitis B virus (HBV) nucleic acid and demonstrated a positive correlation between serum HBV DNA levels and disease progression. Assessment of specific serologic and virologic factors also plays a pivotal role in the diagnosis and effective management of individuals with CHB. Recent development of quantitative assays for intrahepatic HBV replicative intermediates, as well as hepatitis B e antigen and hepatitis B surface antigen, has spurred investigation into the relationship between these factors and response to antiviral therapy and disease progression. Recent findings ... Hepatology International journals http://www.medworm.com/rss/comments.php?id=2810984 Fri, 18 Sep 2009 06:48:41 +0100 2810984 http://www.medworm.com/index.php?rid=2810985&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F12601v2qm448185w%2F Content Type Journal ArticleCategory Supplement ArticleDOI 10.1007/s12072-009-9154-xAuthors Yun-Fan Liaw, Chang Gung Memorial Hospital and University Liver Research Unit 199 Tung Hwa North Road Taipei 105 Taiwan Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=2810985 Fri, 18 Sep 2009 06:48:40 +0100 2810985 http://www.medworm.com/index.php?rid=2810986&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv2320123103j16m6%2F Abstract  A 71-year-old man presented to our hospital with 3-week history of fever in the background of loss of both weight and appetite over the past 3 months. He was found to have a large 10-cm mass in the right lobe of the liver on a triple-phase computed tomographic scan. The tumor showed a distinct fatty component, with areas of arterial enhancement and venous washout suggestive of hepatocellular carcinoma (HCC), another component showing progressive and late enhancement suggestive of cholangiocarcinoma (CC), and a third component showing persistent hypoenhancement relative to the liver parenchyma. He underwent surgical resection. This was histopathologically a biphasic tumor composed of areas showing hepatocytic differentiation, in contiguity with areas showing i... Hepatology International journals http://www.medworm.com/rss/comments.php?id=2810986 Thu, 17 Sep 2009 23:29:21 +0100 2810986 http://www.medworm.com/index.php?rid=2767431&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft565825454j80531%2F Conclusions  The use of NAC causes reduction in NAI-ALF mortality and its use was safe. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-009-9151-0Authors Khalid Mumtaz, Aga Khan University Hospital Department of Medicine Karachi PakistanZahid Azam, Aga Khan University Hospital Department of Medicine Karachi PakistanSaeed Hamid, Aga Khan University Hospital Department of Medicine Karachi PakistanShahab Abid, Aga Khan University Hospital Department of Medicine Karachi PakistanSadik Memon, Isra University Hospital Hyderabad PakistanHasnain Ali Shah, Aga Khan University Hospital Department of Medicine Karachi PakistanWasim Jafri, Aga Khan University Hospital Department of Medicine Karachi Pakistan Journal Hepatology InternationalOnline ISSN 193... Hepatology International journals http://www.medworm.com/rss/comments.php?id=2767431 Thu, 03 Sep 2009 06:33:52 +0100 2767431 http://www.medworm.com/index.php?rid=2717853&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq0n68nv8h7m41837%2F Conclusions  Liver transplantation for acute-on-chronic liver failure is life-saving, and the survival rates it attains are similar to those attained by transplantation for other liver conditions. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-009-9148-8Authors Albert C. Chan, The University of Hong Kong Department of Surgery, Queen Mary Hospital 102 Pok Fu Lam Road Hong Kong ChinaSheung Tat Fan, The University of Hong Kong Department of Surgery, Queen Mary Hospital 102 Pok Fu Lam Road Hong Kong ChinaChung Mau Lo, The University of Hong Kong Department of Surgery, Queen Mary Hospital 102 Pok Fu Lam Road Hong Kong ChinaChi Leung Liu, The University of Hong Kong Department of Surgery, Queen Mary Hospital 102 Pok Fu Lam Road Hong Kong ChinaSee Chin... Hepatology International journals http://www.medworm.com/rss/comments.php?id=2717853 Tue, 18 Aug 2009 22:04:19 +0100 2717853 http://www.medworm.com/index.php?rid=2697569&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F313u028627446878%2F Conclusions  Chest tube insertion for hepatic hydrothorax carries significant morbidity and mortality, with questionable benefit. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-009-9136-zAuthors Eric S. Orman, University of Michigan Department of Internal Medicine Ann Arbor MI USAAnna S. F. Lok, University of Michigan Health System Division of Gastroenterology 3912 Taubman Center, SPC 5362 Ann Arbor MI USA Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=2697569 Tue, 11 Aug 2009 08:42:16 +0100 2697569 http://www.medworm.com/index.php?rid=2686213&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg8086332052jq5w6%2F Abstract  Dual hepatitis B virus (HBV) and hepatitis C virus (HCV) infection are common in HBV or HCV endemic areas. However, several clinical and pathogenetic issues remain unresolved. First, clinical and in vitro studies suggest the interactions between two viruses. The dynamics of the interaction in untreated setting versus treated setting and its influence on the long-term outcomes await further studies. A key issue regarding viral interactions is whether modulation of infection occurs in the same dually infected individual hepatocyte of the liver. Clarifying this issue may help to understand the reciprocal interference between HCV and HBV and provide clues for future immunopathogenetic studies. Second, the prevalence and clinical significance of coexisting occult HBV i... Hepatology International journals http://www.medworm.com/rss/comments.php?id=2686213 Sun, 09 Aug 2009 09:12:38 +0100 2686213 http://www.medworm.com/index.php?rid=2683185&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F455t73r604j432l7%2F Conclusion  We successfully highlighted some potential high HCV endemic townships in Taiwan. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-009-9146-xAuthors Wei-Wen Su, Changhua Christian Hospital Department of Internal Medicine No. 135 Nanxiao Changhua TaiwanChien-Hung Chen, National Taiwan University Hospital and National Taiwan University College of Medicine Department of Internal Medicine No. 7 Chung San South Rd Taipei TaiwanHans Hsienhong Lin, Buddhist Tzu Chi General Hospital Department of Gastroenterology No. 707, Sec. 3, Chung Yang Rd Hualien TaiwanSheng-Shun Yang, Taichung Veterans General Hospital Department of Internal Medicine No. 160, Sec. 3, Chung-Kang Rd Taichung TaiwanTing-Tsung Chang, National Cheng Kung University Hospital Dep... Hepatology International journals http://www.medworm.com/rss/comments.php?id=2683185 Fri, 07 Aug 2009 10:55:04 +0100 2683185 http://www.medworm.com/index.php?rid=2680032&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F057158x58j73nn58%2F Conclusions  Ultrasound surveillance at 6-month intervals was appropriate in general for the detection of HCC at a size smaller than 30 mm. However, in patient with established cirrhosis, more frequent screening would be needed to detect tumors of the same size. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-009-9145-yAuthors Takahisa Sato, University of Tokyo Department of Gastroenterology 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8655 JapanRyosuke Tateishi, University of Tokyo Department of Gastroenterology 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8655 JapanHaruhiko Yoshida, University of Tokyo Department of Gastroenterology 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8655 JapanTakamasa Ohki, University of Tokyo Department of Gastroenterology 7-3-1 Hongo, Bunkyo-ku ... Hepatology International journals http://www.medworm.com/rss/comments.php?id=2680032 Thu, 06 Aug 2009 08:32:35 +0100 2680032 http://www.medworm.com/index.php?rid=2661630&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp302p2g622765217%2F Abstract  The suppression of hepatitis B viral (HBV) load correlates with favorable histologic, biochemical, and serologic responses in clinical trials of patients with chronic hepatitis B (CHB). The ability to identify patients who will not experience durable viral suppression in response to a specific antiviral regimen affords the opportunity for early treatment modification to optimize outcomes and avoid the development of antiviral resistance. Substantial evidence demonstrates that on-treatment serum HBV DNA levels are predictive of virologic response and risk of resistance. Regional clinical practice guidelines for the management of CHB universally recommend monitoring serum HBV DNA levels at treatment week 24. However, the value of this time point as a predictor of lo... Hepatology International journals http://www.medworm.com/rss/comments.php?id=2661630 Thu, 30 Jul 2009 10:08:08 +0100 2661630 http://www.medworm.com/index.php?rid=2661631&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F021712w5646u2683%2F Abstract  There have been major developments in the field of iron metabolism in the past decade following the identification of the HFE gene and the mutation responsible for the C282Y substitution in the HFE protein. While HFE-associated hemochromatosis occurs predominantly in people of northern European extraction, other less-common mutations can lead to the same clinical syndrome and these may occur in other populations in the Asian-Pacific region. The most common of these is the mutation that leads to changes in the ferroportin molecule, the protein responsible for the transport of iron across the basolateral membrane of the enterocyte and from macrophages. Recent research has unraveled the molecular processes of iron transport and regulation of how these are disturbed i... Hepatology International journals http://www.medworm.com/rss/comments.php?id=2661631 Wed, 29 Jul 2009 07:22:46 +0100 2661631 http://www.medworm.com/index.php?rid=2592415&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft451336n28628173%2F Conclusions  Chinese patients with CHB often carry either B or C genotype. Vietnamese patients with CHB mostly have HBV genotype B. Additional studies are needed to further characterize the clinical significance of HBV genotype in the natural history and treatment outcomes of CHB in Vietnamese patients. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-009-9141-2Authors Long H. Nguyen, Stanford University School of Medicine Stanford CA USANghiem B. Ha, Pacific Health Foundation San Jose CA USAPhilip Vutien, Pacific Health Foundation San Jose CA USANghi B. Ha, Pacific Health Foundation San Jose CA USARuel T. Garcia, Pacific Health Foundation San Jose CA USAHuy N. Trinh, Pacific Health Foundation San Jose CA USABrian S. Levitt, San Jose Gastroentero... Hepatology International journals http://www.medworm.com/rss/comments.php?id=2592415 Fri, 10 Jul 2009 08:05:02 +0100 2592415 http://www.medworm.com/index.php?rid=2592416&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0278pt7521r52225%2F This article reviews these issues and highlights areas in which their engagement with public health efforts serves to improve quality of life and society as a whole. Content Type Journal ArticleCategory Supplement ArticleDOI 10.1007/s12072-009-9142-1Authors Nancy Leung, Chinese University of Hong Kong Department of Medicine, Alice Ho Miu Ling Nethersole Hospital Room 65, J6, 11 Chuen On Road, Tai Po, NT Hong Kong SAR China Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=2592416 Thu, 09 Jul 2009 12:02:21 +0100 2592416 http://www.medworm.com/index.php?rid=2516101&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft03880026144106w%2F Conclusions  Limited access to HBV resistance tests causes physicians in Asia to manage suspected resistance by various HBV DNA assays and ALT tests. This raises concerns that resistance may not be detected early enough to be rescued efficiently. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-009-9139-9Authors Siwaporn Chainuvati, Mahidol University Department of Medicine, Siriraj Hospital 2 Prannok Road, Bangkok-noi Bangkok 10700 ThailandJun Cheng, Beijing Ditan Hospital No 8, Shundong Jie, Chaoyang District Beijing 100015 ChinaJin Lin Hou, Southern Medical University Hepatology Unit and Department of Infectious Diseases, Institute of Gastroenterology, Nanfang Hospital Guangzhou 510515 Guangdong ChinaChao Wei Hsu, Chang Gung Memorial Hospital a... Hepatology International journals http://www.medworm.com/rss/comments.php?id=2516101 Wed, 24 Jun 2009 06:08:33 +0100 2516101 http://www.medworm.com/index.php?rid=2516102&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr7155p50164u6701%2F Abstract  During the natural history of chronic hepatitis B virus (HBV) infection, the loss of serum hepatitis B e antigen (HBeAg) and the development of anti-HBe antibodies (HBeAg seroconversion) mark a transition from the immune-active phase of disease to the inactive carrier state. This review examines the evidence from natural history and cohort studies on the relationship between HBeAg seroconversion and disease progression. The role of HBeAg seroconversion as an important milestone in the management of HBeAg-positive patients with chronic hepatitis B (CHB), as well as the advantages and disadvantages of administering a finite course of therapy for HBeAg-positive CHB, is also discussed. The evidence from natural history and cohort studies indicates that spontaneous or ... Hepatology International journals http://www.medworm.com/rss/comments.php?id=2516102 Wed, 24 Jun 2009 06:08:31 +0100 2516102 http://www.medworm.com/index.php?rid=2490824&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F64w7829018654044%2F Conclusions  Hepatocellular cholesterol metabolism was at least partially disturbed, even in the early stage of PBC. The most characteristic finding was a distinct elevation of MDR3 expression, and the MDR3 levels were negatively correlated with GGT and IgM levels. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-009-9137-yAuthors Munechika Enjoji, Fukuoka University Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences 8-19-1 Nanakuma, Jonan-ku Fukuoka 814-0180 JapanRyoko Yada, National Hospital Organization Clinical Research Center, Kyushu Medical Center Fukuoka JapanTatsuya Fujino, National Hospital Organization Clinical Research Center, Kyushu Medical Center Fukuoka JapanTsuyoshi Yoshimoto, National Hospital Organization Depa... Hepatology International journals http://www.medworm.com/rss/comments.php?id=2490824 Wed, 17 Jun 2009 07:11:38 +0100 2490824 http://www.medworm.com/index.php?rid=2490825&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fwt7591335m7524l7%2F Content Type Journal ArticleCategory EditorialDOI 10.1007/s12072-009-9138-xAuthors Ching-Lung Lai, The University of Hong Kong Department of Medicine Queen Mary Hospital, Pokfulam Hong Kong ChinaMan-Fung Yuen, The University of Hong Kong Department of Medicine Queen Mary Hospital, Pokfulam Hong Kong China Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=2490825 Wed, 17 Jun 2009 07:11:37 +0100 2490825 http://www.medworm.com/index.php?rid=2434443&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn43145354k211829%2F Conclusion  Entecavir 0.01–0.5 mg is well tolerated and produces a dose-dependent reduction in viral load in nucleoside-naive Japanese patients with CHB. Compared with lamivudine 100 mg, entecavir 0.1 mg demonstrated noninferiority and entecavir 0.5 mg was superior in this population. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-009-9135-0Authors Michiko Shindo, Akashi Municipal Hospital Division of Liver Disease, Department of Internal Medicine 1-33 Takasyo-machi, Akashi-shi Hyogo JapanKazuaki Chayama, Hiroshima University Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences Hiroshima JapanSatoshi Mochida, Saitama Medical University Department of Gastroenterology and Hepatology Saitama Ja... Hepatology International journals http://www.medworm.com/rss/comments.php?id=2434443 Sun, 24 May 2009 06:11:02 +0100 2434443 http://www.medworm.com/index.php?rid=2432814&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe24m6678xn821177%2F In conclusion, in patients infected with HCV genotype 2 and pretreatment viral load below 1000 kIU/ml who achieve RVR, 24-week treatment with peginterferon α-2a alone is clinically sufficient. Those who show no RVR or have higher baseline viral load, require alternative therapies. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-009-9134-1Authors Yoshiaki Iwasaki, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Department of Gastroenterology and Hepatology 2-5-1, Shikata-cho Okayama 700-8558 JapanYasushi Shiratori, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Department of Gastroenterology and Hepatology 2-5-1, Shikata-cho Okayama 700-8558 JapanShuhei Hige, Hokkaido Universi... Hepatology International journals http://www.medworm.com/rss/comments.php?id=2432814 Fri, 22 May 2009 05:46:07 +0100 2432814 http://www.medworm.com/index.php?rid=2400552&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F666n160u58737272%2F Conclusion  Natural history and management of HVD was different from hepatic vein thrombosis caused by hypercoagulable condition, a disease with which it is commonly grouped together under Budd-Chiari syndrome. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-009-9133-2Authors Santosh Man Shrestha, Liver Foundation Nepal Sitapaela Height P.O. Box No. 3439 Kathmandu Nepal Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=2400552 Fri, 08 May 2009 05:57:17 +0100 2400552 http://www.medworm.com/index.php?rid=2400553&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fmrk2860244223505%2F Conclusions  In patients with unresectable HCC, TACE + thymalfasin resulted in numerically higher rates of survival and tumor response, including transplant candidacy, with fewer bacterial infections, than TACE alone. Treatment regimens for HCC including thymalfasin as an immunomodulator should be evaluated in larger trials. Content Type Journal ArticleCategory Original articleDOI 10.1007/s12072-009-9132-3Authors Robert G. Gish, California Pacific Medical Center Department of Hepatology and Complex Gastroenterology 2340 Clay St. #233 San Francisco CA 94115 USAStuart C. Gordon, Henry Ford Health System Division of Hepatology 2799 West Grand Boulevard Detroit MI 48202-2689 USADavid Nelson, University of Florida College of Medicine Section of Hepatology and Live... Hepatology International journals http://www.medworm.com/rss/comments.php?id=2400553 Fri, 08 May 2009 05:57:16 +0100 2400553 http://www.medworm.com/index.php?rid=2400554&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F382p114l818705ju%2F We report a case of cerebral embolism a few hours after an injection of Histoacryl into a bleeding esophageal post-banding ulcer. Echocardiogram revealed patent foramen ovale. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s12072-009-9130-5Authors Asmarani Abdullah, Selayang Hospital Hepatology Unit Lebohraya Selayang-Kepong 68100 Batu Caves Selangor MalaysiaSharmila Sachithanandan, Selayang Hospital Hepatology Unit Lebohraya Selayang-Kepong 68100 Batu Caves Selangor MalaysiaOoi Keat Tan, Selayang Hospital Hepatology Unit Lebohraya Selayang-Kepong 68100 Batu Caves Selangor MalaysiaYee Ming Chan, Selayang Hospital Hepatology Unit Lebohraya Selayang-Kepong 68100 Batu Caves Selangor MalaysiaDennise Khoo, Selayang Hospital Hepatology Unit Lebohraya Selayang-Kepong 68100 Bat... Hepatology International journals http://www.medworm.com/rss/comments.php?id=2400554 Wed, 06 May 2009 05:55:38 +0100 2400554 http://www.medworm.com/index.php?rid=2384186&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk0710140075170l4%2F Abstract  Two patients developed segmental, diffuse intrahepatic recurrence after percutaneous radiofrequency ablation (RFA) to treat a primary, solitary, and small (2.5 cm) hepatocellular carcinoma (HCC). Despite the size of the HCC, levels of the tumor markers (α-fetoprotein, α-fetoprotein-L3%, and des-γ-carboxyprothrombin) were all elevated before RFA, and tumors in both patients were contiguous with a major branch of the portal vein. Tumor biopsies of both patients revealed moderately differentiated HCC but diagnostic imaging showed an area of reduced tumor blood flow, suggesting a poorly differentiated component. Since early detection of post-RFA malignancies by standard ultrasonography and contrast-enhanced computed tomography was difficult, the most sensitive... Hepatology International journals http://www.medworm.com/rss/comments.php?id=2384186 Thu, 30 Apr 2009 06:07:29 +0100 2384186 http://www.medworm.com/index.php?rid=2357836&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq5803h273175u108%2F Abstract  Inhibition of the proliferation of hepatic stellate cells (HSC) is clinically important for the control of liver fibrosis and cirrhosis. Interferons are now frequently used for chronic viral hepatitis because of their anti-viral activity. However, patients treated with interferons exhibit a regression of liver fibrosis even if viral eradication is not achieved, indicating that interferon itself has anti-fibrotic activity. Herein, we show the anti-proliferation and pro-apoptotic activity of natural interferon α against HSC. We found that interferon α inhibited serum-stimulated [3H]thymidine incorporation of HSC in a dose-dependent manner, with a significant reduction at more than 100 U/ml. Interferon α also attenuated PDGF-BB-stimulated DNA synthesis of HSC.... Hepatology International journals http://www.medworm.com/rss/comments.php?id=2357836 Tue, 21 Apr 2009 10:57:52 +0100 2357836 http://www.medworm.com/index.php?rid=3098250&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl08h605237358321%2F We describe three cases of well-differentiated hepatocellular carcinoma (HCC) smaller than 15 mm in diameter completely eradicated with percutaneous ethanol injection (PEI) instead of using radiofrequency ablation (RFA). Ultrasound (US) examination revealed one nodule each in segment 2 (hypoechoic, near bile ducts, 10 mm), in segment 5 (hyperechoic, near the gall bladder, 15 mm), and in segment 7 (hypoechoic, near the diaphragm, 15 mm). Although imaging studies revealed isovascular (case 1) and hypervascular (cases 2 and 3) nodules, histological analysis of US-guided biopsy tissue revealed well-differentiated HCC. In consideration of the location of the nodules, PEI, instead of RFA, was administered and the nodules were rendered necrotic. Although RFA is superior ... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3098250 Sat, 21 Mar 2009 09:05:21 +0100 3098250 http://www.medworm.com/index.php?rid=2288677&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl08h605237358321%2F We describe three cases of well-differentiated hepatocellular carcinoma (HCC) smaller than 15 mm in diameter completely eradicated with percutaneous ethanol injection (PEI) instead of using radiofrequency ablation (RFA). Ultrasound (US) examination revealed one nodule each in segment 2 (hypoechoic, near bile ducts, 10 mm), in segment 5 (hyperechoic, near the gall bladder, 15 mm), and in segment 7 (hypoechoic, near the diaphragm, 15 mm). Although imaging studies revealed isovascular (case 1) and hypervascular (cases 2 and 3) nodules, histological analysis of US-guided biopsy tissue revealed well-differentiated HCC. In consideration of the location of the nodules, PEI, instead of RFA, was administered and the nodules were rendered necrotic. Although RFA is superior ... Hepatology International journals http://www.medworm.com/rss/comments.php?id=2288677 Sat, 21 Mar 2009 09:05:21 +0100 2288677 http://www.medworm.com/index.php?rid=2277756&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F916k83567256088u%2F Conclusions  IL-18 promoter polymorphism at −607 position with A/A allele is a potential protective marker, as it is associated with milder liver disease in patients with chronic HCV infection. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-009-9127-0Authors K. Manohar, G.B. Pant Hospital Department of Gastroenterology New Delhi IndiaP. V. Suneetha, G.B. Pant Hospital Department of Gastroenterology New Delhi IndiaSukriti, G.B. Pant Hospital Department of Gastroenterology New Delhi IndiaNirupama Trehan Pati, G.B. Pant Hospital Department of Gastroenterology New Delhi IndiaAbhishek C. Gupta, G.B. Pant Hospital Department of Gastroenterology New Delhi IndiaSyed Hissar, G.B. Pant Hospital Department of Gastroenterology New Delhi IndiaPuja Sakhuja,... Hepatology International journals http://www.medworm.com/rss/comments.php?id=2277756 Tue, 17 Mar 2009 07:08:16 +0100 2277756 http://www.medworm.com/index.php?rid=2240645&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3307013x44153967%2F Abstract  Hepatocellular adenoma is a rare benign tumor of the liver. However, some complications, such as hemorrhage, rupture, and malignant transformation, have been reported previously. Surgical resection is considered to be the best choice of treatment, when adenomas are increasing in size, while resection is difficult to perform when multiple adenomas develop throughout the liver. Here, we report two cases of multiple hepatocellular adenomatosis. One patient had a history of aplastic anemia and the other had glycogen storage disease. We treated them with transcatheter arterial embolization (TAE) to prevent hemorrhage and rupture. After TAE, most parts of the adenomas showed necrotic change. These cases suggest that TAE is an effective treatment of hepatocellular adenom... Hepatology International journals http://www.medworm.com/rss/comments.php?id=2240645 Thu, 05 Mar 2009 12:30:04 +0100 2240645 http://www.medworm.com/index.php?rid=2152847&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw57xj6q330238g07%2F Content Type Journal ArticleDOI 10.1007/s12072-009-9124-3 Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=2152847 Sat, 31 Jan 2009 07:35:19 +0100 2152847 http://www.medworm.com/index.php?rid=2152849&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd7525421707832np%2F Content Type Journal ArticleDOI 10.1007/s12072-009-9125-2 Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=2152849 Sat, 31 Jan 2009 07:35:18 +0100 2152849 http://www.medworm.com/index.php?rid=2152848&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm1w2467r8g12850r%2F Content Type Journal ArticleDOI 10.1007/s12072-009-9123-4 Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=2152848 Sat, 31 Jan 2009 07:35:18 +0100 2152848 http://www.medworm.com/index.php?rid=2131272&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj6w026l800708342%2F Conclusion  HVD is independent risk factors for LC and HCC. Severe and/or recurrent loss of hepatocytes caused by hepatic venous outflow obstruction and/or thrombotic obstruction of small radicals of hepatic and portal veins that occurred during acute exacerbations was considered important in the pathogenesis of LC and HCC in HVD. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-009-9122-5Authors Santosh Man Shrestha, Liver Foundation Nepal Sitapaela Height P.O. Box 3439 Kathmandu Nepal Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=2131272 Fri, 23 Jan 2009 09:39:56 +0100 2131272 http://www.medworm.com/index.php?rid=2131273&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa65413518m176104%2F Content Type Journal ArticleDOI 10.1007/s12072-008-9121-y Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=2131273 Fri, 23 Jan 2009 09:39:52 +0100 2131273 http://www.medworm.com/index.php?rid=2128818&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh57160722q261058%2F Content Type Journal ArticleDOI 10.1007/s12072-008-9118-6 Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=2128818 Thu, 22 Jan 2009 00:11:46 +0100 2128818 http://www.medworm.com/index.php?rid=2128821&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fgp55468501063394%2F Content Type Journal ArticleDOI 10.1007/s12072-008-9119-5 Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=2128821 Thu, 22 Jan 2009 00:11:45 +0100 2128821 http://www.medworm.com/index.php?rid=2128820&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fqx0124581r174w57%2F Content Type Journal ArticleDOI 10.1007/s12072-008-9117-7 Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=2128820 Thu, 22 Jan 2009 00:11:45 +0100 2128820 http://www.medworm.com/index.php?rid=2128819&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F11n87x8544677043%2F Content Type Journal ArticleDOI 10.1007/s12072-008-9120-z Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=2128819 Thu, 22 Jan 2009 00:11:45 +0100 2128819 http://www.medworm.com/index.php?rid=2055781&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd49jq42518787683%2F Conclusion  Contaminated water and suspected ice cream were associated with outbreaks of hepatitis A. Viral genetic analysis may advance field investigations in complex situations. Content Type Journal ArticleCategory ORIGINAL ARTICLEDOI 10.1007/s12072-008-9116-8Authors Jingyuan Cao, Chinese Center for Disease Control and Prevention Division of Hepatitis, National Institute for Viral Disease Control and Prevention Yingxin Street 100, Xuanwu District Beijing 100052 People’s Republic of ChinaYue Wang, Chinese Center for Disease Control and Prevention Division of Hepatitis, National Institute for Viral Disease Control and Prevention Yingxin Street 100, Xuanwu District Beijing 100052 People’s Republic of ChinaHaiyan Song, Harbin Medical University Second Hospital Depart... Hepatology International journals http://www.medworm.com/rss/comments.php?id=2055781 Fri, 19 Dec 2008 08:21:09 +0100 2055781 http://www.medworm.com/index.php?rid=2055782&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv2h5816310836610%2F Abstract  To address the relationship between hepatitis B virus (HBV) endemicity and HBV-related liver diseases in Mexico. Research literature reporting on HBsAg and antibody to hepatitis B core antigen (anti-HBc) prevalence in Mexican study groups were searched in NLM Gateway, PubMed, IMBIOMED, and others. Weighted mean prevalence (WMP) was calculated from the results of each study group. A total of 50 studies were analyzed. Three nationwide surveys revealed an HBsAg seroprevalence of less than 0.3%. Horizontal transmission of HBV infection occurred mainly by sexual activity and exposure to both contaminated surgical equipment and body fluids. High-risk groups exposed to these factors included healthcare workers, pregnant women, female sex workers, hemodialysis patients, a... Hepatology International journals http://www.medworm.com/rss/comments.php?id=2055782 Fri, 19 Dec 2008 08:21:08 +0100 2055782 http://www.medworm.com/index.php?rid=2033003&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F015572731502117t%2F Abstract  The activation of hepatic stellate cells (HSCs) is a cue to initiate liver fibrosis. Activated stellate cells acquire contractile activity similar to pericytes and myofibroblasts in other organs by inducing the contractile machinery of cytoskeletons such as smooth muscle α-actin (α-SMA), a well-known marker of activated stellate cells, and actin-binding proteins. We further show herein the expression of tropomyosin in rat HSCs in the course of their activation during primary culture and liver tissue damaged by thioacetamide intoxication. In immunoblot analysis, tropomyosin became detectable in an early stage of the primary culture of rat stellate cells in a manner similar to the expression of α-SMA and platelet-derived growth factor receptor-β. Tropomyosin was... Hepatology International journals http://www.medworm.com/rss/comments.php?id=2033003 Thu, 11 Dec 2008 12:15:52 +0100 2033003 http://www.medworm.com/index.php?rid=2033004&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx6176676552510m1%2F Conclusions  EHPVO patients have hyperdynamic circulation manifested by high cardiac index and low systemic and pulmonary vascular resistance indices. These hemodynamic changes are comparable with compensated cirrhotic patients who have similar grade of portal hypertension. This suggests a predominant role of portal hypertension per se in the genesis of systemic and pulmonary hemodynamic alterations. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-008-9110-1Authors Sanjeev Kumar Jha, Affiliated to University of Delhi Department of Gastroenterology, G B Pant Hospital Room 201, Academic Block New Delhi 110 002 IndiaAshish Kumar, Affiliated to University of Delhi Department of Gastroenterology, G B Pant Hospital Room 201, Academic Block New Delhi 1... Hepatology International journals http://www.medworm.com/rss/comments.php?id=2033004 Wed, 10 Dec 2008 07:40:39 +0100 2033004 http://www.medworm.com/index.php?rid=2033005&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn561v2124k2774w2%2F Conclusions  ETVr emerged in two Japanese nucleoside-naive CHB patients after prolonged therapy and incomplete suppression and in one patient after <0.5 mg of dosing. ETV patients with detectable HBV DNA or breakthrough after extended therapy should be evaluated for compliance to therapy and potential emergence of resistance. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s12072-008-9108-8Authors Haruhiko Kobashi, Okayama University Department of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Okayama JapanShin-ichi Fujioka, Okayama Saiseikai General Hospital Department of Medicine Okayama JapanMitsuhiko Kawaguchi, Okayama Saiseikai General Hospital Department of Medicine Okayama JapanHiromitsu K... Hepatology International journals http://www.medworm.com/rss/comments.php?id=2033005 Wed, 10 Dec 2008 07:40:38 +0100 2033005 http://www.medworm.com/index.php?rid=2017462&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F085613458702736k%2F Abstract  Liver fibrosis is a common pathway leading to cirrhosis, which is the final result of injury to the liver. Accurate assessment of the degree of fibrosis is important clinically, especially when treatments aimed at reversing fibrosis are being evolved. Liver biopsy has been considered to be the “gold standard” to assess fibrosis. However, liver biopsy being invasive and, in many instances, not favored by patients or physicians, alternative approaches to assess liver fibrosis have assumed great importance. Moreover, therapies aimed at reversing the liver fibrosis have also been tried lately with variable results. Till now, there has been no consensus on various clinical, pathological, and radiological aspects of liver fibrosis. The Asian Pacific Association for ... Hepatology International journals http://www.medworm.com/rss/comments.php?id=2017462 Thu, 04 Dec 2008 06:56:48 +0100 2017462 http://www.medworm.com/index.php?rid=2011005&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa0k77675x7466275%2F Conclusions  Our findings suggest that HBV infection itself does not affect adiponectin levels. Serum adiponectin level correlates with the progression of HBV-related liver diseases but not with the development of HBeAg SC. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-008-9111-0Authors Chun-Jen Liu, National Taiwan University College of Medicine, National Taiwan University Hospital Graduate Institute of Clinical Medicine No. 7, Chung-Shan South Road Taipei 10002 TaiwanPei-Jer Chen, National Taiwan University College of Medicine, National Taiwan University Hospital Graduate Institute of Clinical Medicine No. 7, Chung-Shan South Road Taipei 10002 TaiwanMing-Yang Lai, National Taiwan University College of Medicine, National Taiwan University Hosp... Hepatology International journals http://www.medworm.com/rss/comments.php?id=2011005 Tue, 02 Dec 2008 07:36:15 +0100 2011005 http://www.medworm.com/index.php?rid=1996214&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3828566682040307%2F Conclusions  Studies to date suggest that HBV genotypes/subgenotypes have important influences on the outcome of chronic HBV infection, but more population-based prospective studies examining multiple genotypes are needed. Content Type Journal ArticleCategory Review ArticleDOI 10.1007/s12072-008-9112-zAuthors Brian J. McMahon, Alaska Native Tribal Health Consortium; and Arctic Investigations Program, Centers for Disease Control and Prevention Liver Disease and Hepatitis Program 4315 Diplomacy Drive Anchorage AK 99508 USA Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=1996214 Wed, 26 Nov 2008 20:04:24 +0100 1996214 http://www.medworm.com/index.php?rid=1980532&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg0627470564r1008%2F Abstract  The Asian Pacific Association for the Study of the Liver (APASL) set up a working party on acute-on-chronic liver failure (ACLF) in 2004, with a mandate to develop consensus guidelines on various aspects of ACLF relevant to disease patterns and clinical practice in the Asia-Pacific region. Experts predominantly from the Asia–Pacific region constituted this working party and were requested to identify different issues of ACLF and develop the consensus guidelines. A 2-day meeting of the working party was held on January 22–23, 2008, at New Delhi, India, to discuss and finalize the consensus statements. Only those statements that were unanimously approved by the experts were accepted. These statements were circulated to all the experts and subsequently presented ... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1980532 Thu, 20 Nov 2008 08:14:00 +0100 1980532 http://www.medworm.com/index.php?rid=1963889&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg07u03u81317g8qt%2F Abstract  Based on clinical and pathological experience, indistinct margin-type hepatocellular carcinomas (HCCs) were considered to be typical early-stage HCCs with good prognosis. For histological diagnosis, the assessment of stromal invasion (tumor invasion into portal tracts and fibrous septa) is very important. In differentiating stromal invasion from pseudoinvasion (benign hepatic tissue in the fibrous stroma), the following 5 items are useful: (1) macroscopic or panoramic views of the histological specimen, (2) amount of fibrous components of the stroma, (3) destruction of the structure of portal tracts, (4) loss of reticulin fibers around cancer cells, and (5) cytokeratin 7 immunostaining for ductular proliferation. Parenchymal features of early HCCs are summarized a... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1963889 Fri, 14 Nov 2008 08:04:48 +0100 1963889 http://www.medworm.com/index.php?rid=1955159&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk732065865731706%2F Abstract  Cirrhotic cardiomyopathy is a recently recognized condition in cirrhosis consisting of systolic incompetence under condition of stress, diastolic dysfunction related to altered diastolic relaxation, and electrophysiological abnormalities in the absence of any known cardiac disease. It can be diagnosed by using a combination of electrocardiograph, 2-dimensional echocardiography, and various serum markers such as brain natriuretic factor. The underlying pathogenetic mechanisms include abnormalities in the β-adrenergic signaling pathway, altered cardiomyocyte membrane fluidity, increased myocardial fibrosis, cardiomyocyte hypertrophy, and ion channel defects. Various compounds for which levels are elevated in cirrhosis such as nitric oxide and carbon monoxide can al... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1955159 Tue, 11 Nov 2008 08:00:00 +0100 1955159 http://www.medworm.com/index.php?rid=1901336&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj5048877t605460k%2F Conclusions  It is important when comparing resistance rates to antiviral drugs in CHB to consider the methodology and definition of resistance used because this can dramatically influence the results. Content Type Journal ArticleCategory Review ArticleDOI 10.1007/s12072-008-9105-yAuthors Hie-Won Hann, Jefferson Medical College Division of Gastroenterology and Hepatology, Department of Medicine 1025 Walnut Street Philadelphia PA 19107 USAVicki L. Gregory, Writeology 19 Riddy Lane, Bourn Cambridge CB23 2SP UKJonathan S. Dixon, GlaxoSmithKline 980 Great West Road Brentford, Middlesex TW8 9GS UKKeith F. Barker, GlaxoSmithKline 980 Great West Road Brentford, Middlesex TW8 9GS UK Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepato... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1901336 Tue, 21 Oct 2008 05:55:41 +0100 1901336 http://www.medworm.com/index.php?rid=1883260&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F82308027h9465502%2F Conclusions  The present study demonstrated profound metabolic changes before, during, and after warm liver ischemia under the influence of IPC. Compared with a similar study without IPC, the metabolic changes seem to be unaffected by preconditioning. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-008-9104-zAuthors Anne-Sofie Kannerup, Aarhus University Hospital Department of Surgical Gastroenterology L 8000 Aarhus C DenmarkHenning Grønbæk, Aarhus University Hospital Department of Medical Gastroenterology V 8000 Aarhus C DenmarkPeter Funch-Jensen, Aarhus University Hospital Department of Surgical Gastroenterology L 8000 Aarhus C DenmarkRasmus Langelund Jørgensen, Aarhus University Hospital Department of Surgical Gastroenterology L 8000 Aarhus... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1883260 Wed, 15 Oct 2008 10:52:42 +0100 1883260 http://www.medworm.com/index.php?rid=1883259&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq7x566p230374572%2F Conclusions  This study furthers current knowledge of HBV epidemiology in areas with large populations of high-risk immigrants and demonstrates the relevance of screening programs for hepatitis B. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-008-9103-0Authors Naoky C. S. Tsai, Hawaii Medical Center Liver Center 2230 Liliha Street, 2MA Honolulu HI 96817 USAPeter S. Holck, University of Hawaii at Manoa Department of Public Health Sciences, John A. Burns School of Medicine 1960 East-West Road, Biomed D204 Honolulu HI 96822 USALinda L. Wong, University of Hawaii at Manoa Department of Surgery, John A. Burns School of Medicine 1356 Lusitana Street, 6th Floor Honolulu HI 96813 USAAldrich A. Ricalde, Hawaii Medical Center Liver Center 2230 Liliha Str... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1883259 Wed, 15 Oct 2008 10:52:42 +0100 1883259 http://www.medworm.com/index.php?rid=1850919&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9664l33q6hg64802%2F We describe a case of activation of chronic hepatitis B infection associated with imatinib therapy. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s12072-008-9099-5Authors Shilen Lakhani, Georgetown University School of Medicine Section of Gastroenterology and Hepatology, Washington Hospital Center 110 Irving Street NW Washington DC 20010 USALev Davidson, Georgetown University School of Medicine Washington Cancer Institute, Washington Hospital Center 110 Irving Street NW Washington DC 20010 USADennis A. Priebat, Georgetown University School of Medicine Washington Cancer Institute, Washington Hospital Center 110 Irving Street NW Washington DC 20010 USAAverell H. Sherker, Georgetown University School of Medicine Section of Gastroenterology and Hepatology, Washington Hospit... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1850919 Thu, 02 Oct 2008 09:29:02 +0100 1850919 http://www.medworm.com/index.php?rid=1825435&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb806775804043448%2F Abstract  A case of de novo acute hepatitis B that showed symptoms of general malaise and anorexia during rituximab therapy with the CHOP regimen for diffuse large B cell lymphoma is reported. Lamivudine was strikingly effective, showing a rapid recovery from liver damage with jaundice. Hepatitis B virus (HBV) DNA in serum became and stayed undetectable even after the withdrawal of lamivudine, although HBsAg remained positive over 42 months from the onset. Liver biopsy showed a picture suggestive of acute viral hepatitis with multinucleated giant hepatocytes and CD38-positive plasma cell infiltration into liver parenchyma. Immunohistochemically, CD3-positive T-cells were predominant cells that infiltrated in liver parenchyma, whereas CD20-positive B cells were ess... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1825435 Tue, 23 Sep 2008 10:23:32 +0100 1825435 http://www.medworm.com/index.php?rid=1815202&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9325q682nq127278%2F Conclusions  Growth retardation by anthropometry was documented in a quarter of patients with EHPVO. All patients had significantly low IGF-1 and IGFBP-3 levels in comparison with controls despite normal anthropometry in majority of patients (75%). Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-008-9102-1Authors Lalit Nihal, Seth GS Medical College and KEM Hospital Department of Gastroenterology Parel Mumbai 400 012 Maharashtra IndiaMukta R. Bapat, Seth GS Medical College and KEM Hospital Department of Gastroenterology Parel Mumbai 400 012 Maharashtra IndiaPravin Rathi, Seth GS Medical College and KEM Hospital Department of Gastroenterology Parel Mumbai 400 012 Maharashtra IndiaNalini S. Shah, Seth GS Medical College and KEM Hospital Department ... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1815202 Sat, 20 Sep 2008 09:56:04 +0100 1815202 http://www.medworm.com/index.php?rid=1815201&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr5vt506828h84mt2%2F Content Type Journal ArticleDOI 10.1007/s12072-008-9101-2 Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=1815201 Sat, 20 Sep 2008 09:56:04 +0100 1815201 http://www.medworm.com/index.php?rid=1815203&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq7030264u3445l09%2F Abstract  Ascites and hepatorenal syndrome (HRS) are the major and challenging complications of cirrhosis and portal hypertension that significantly affect the course of the disease. Liver insufficiency, portal hypertension, arterial vasodilatation, and systemic cardiovascular dysfunction are major pathophysiological hallmarks. Modern treatment of ascites is based on this recognition and includes modest salt restriction and stepwise diuretic therapy with spironolactone and loop diuretics. Tense and refractory ascites should be treated with a large volume paracentesis, followed by volume expansion or transjugular intrahepatic portosystemic shunt. New treatment strategies include the use of vasopressin V2-receptor antagonists and vasoconstrictors. The HRS denotes a functional ... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1815203 Sat, 20 Sep 2008 09:56:02 +0100 1815203 http://www.medworm.com/index.php?rid=1806164&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj05805439g558477%2F Conclusion  A high level of systemic oxidative stress exists in ALF, with depletion of antioxidant reserves. Further studies are needed to define the clinical correlation of the large pro-oxidant burden. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-008-9098-6Authors Vikram Bhatia, All India Institute of Medical Sciences Department of Gastroenterology and Human Nutrition New Delhi 110029 IndiaPayal Bhardwaj, All India Institute of Medical Sciences Department of Gastroenterology and Human Nutrition New Delhi 110029 IndiaJessina Elikkottil, All India Institute of Medical Sciences Department of Gastroenterology and Human Nutrition New Delhi 110029 IndiaJyoti Batra, All India Institute of Medical Sciences Department of Gastroenterology and Human Nu... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1806164 Tue, 16 Sep 2008 09:25:46 +0100 1806164 http://www.medworm.com/index.php?rid=1782542&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn7hu72717603u110%2F Conclusions  LSM is potentially useful to predict the development of postoperative hepatic insufficiency in patients with hepatocellular carcinoma undergoing curative liver resection surgery. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-008-9091-0Authors Seung Up Kim, Yonsei University College of Medicine Department of Internal Medicine 250 Seongsanno, Seodaemun-gu Seoul 120–752 Republic of KoreaSang Hoon Ahn, Yonsei University College of Medicine Department of Internal Medicine 250 Seongsanno, Seodaemun-gu Seoul 120–752 Republic of KoreaJun Yong Park, Yonsei University College of Medicine Department of Internal Medicine 250 Seongsanno, Seodaemun-gu Seoul 120–752 Republic of KoreaDo Young Kim, Yonsei University College of Medicine Depart... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1782542 Tue, 09 Sep 2008 00:35:13 +0100 1782542 http://www.medworm.com/index.php?rid=1775500&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw8665n1631l0636p%2F Conclusion  Persistence of HBeAg at 1 year and HBV DNA nonresponder at 6 months are good predictors of development of VBT. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-008-9095-9Authors Shahinul Alam, Bangabandhu Sheikh Mujib Medical University Department of Hepatology Shahbag Dhaka BangladeshGolam Azam, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders Department of Immunology Shahbag Dhaka BangladeshGolam Mustafa, Bangabandhu Sheikh Mujib Medical University Department of Hepatology Shahbag Dhaka BangladeshNooruddin Ahmad, Bangabandhu Sheikh Mujib Medical University Department of Hepatology Shahbag Dhaka BangladeshBelalul Islam, Bangabandhu Sheikh Mujib Medical University Department of... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1775500 Fri, 05 Sep 2008 15:13:38 +0100 1775500 http://www.medworm.com/index.php?rid=1775501&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm7026r27xu6022p8%2F Abstract  The Asian Pacific Association for the Study of the Liver (APASL) set up a Working Party on Portal Hypertension in 2002, with a mandate to develop consensus guidelines on various clinical aspects of portal hypertension relevant to disease patterns and clinical practice in the Asia-Pacific region. Variceal bleeding is a consequence of portal hypertension, which, in turn, is the major complication of liver cirrhosis. Primary prophylaxis to prevent the first bleed from varices is one of the most important strategies for reducing the mortality in cirrhotic patients. Experts predominantly from the Asia-Pacific region were requested to identify the different aspects of primary prophylaxis and develop the consensus guidelines. The APASL Working Party on Portal Hypertensio... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1775501 Fri, 05 Sep 2008 15:13:37 +0100 1775501 http://www.medworm.com/index.php?rid=1763843&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fuj7qt2440j316206%2F Content Type Journal ArticleCategory EditorialDOI 10.1007/s12072-008-9097-7Authors Flemming Bendtsen, University of Copenhagen Department of Medical Gastroenterology 439, Hvidovre Hospital and Faculty of Health Science Hvidovre 2650 DenmarkSøren Møller, University of Copenhagen Department of Clinical Physiology and Nuclear Medicine 239, Hvidovre Hospital and Faculty of Health Science Hvidovre 2650 Denmark Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=1763843 Wed, 03 Sep 2008 08:19:08 +0100 1763843 http://www.medworm.com/index.php?rid=1763844&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fkq2m1114786453nx%2F Abstract  Biliary complications of living donor liver transplantation remain common. The complications of biliary leakage and stricture result in substantial recipient morbidity. A major focus of liver transplantation research is the prevention and reduction of these complications through identification of the multiple factors that are conducive to them. Such factors include the donor bile duct anatomy and quality, and the techniques of donor hepatectomy, recipient hepatectomy, and ductal reconstruction. A low threshold for re-exploration for possible bile leakage prevents development of uncontrolled sepsis. Return of good graft function can usually be expected after successful early endoscopic treatment. Contingent measures of percutaneous transhepatic dilatation and stent... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1763844 Wed, 03 Sep 2008 08:19:05 +0100 1763844 http://www.medworm.com/index.php?rid=1763845&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb016t1578611hq85%2F This article reviews the development of a human recombinant single-chain antibody (scAb) that binds to the surface of myofibroblasts. This antibody binds specifically to myofibroblasts in fibrotic mouse livers. When conjugated with a compound that stimulates myofibroblast apoptosis, the antibody directs the specific apoptosis of myofibroblasts with greater specificity and efficacy than the free compound. The antibody also reduces the adverse effect of liver macrophage apoptosis and—in contrast to the free compound—reversed fibrosis in the sustained injury model used. These data suggest that specifically stimulating the apoptosis of liver myofibroblasts using a targeting antibody has potential in the treatment of liver fibrosis. Content Type Journal ArticleCategory Review Artic... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1763845 Wed, 03 Sep 2008 08:19:02 +0100 1763845 http://www.medworm.com/index.php?rid=1750013&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk545251256571161%2F Conclusions  Through 96 weeks of treatment, entecavir resulted in continued clinical benefit in nucleoside-naïve Chinese patients with CHB, with a safety profile comparable with lamivudine. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-008-9088-8Authors Guangbi Yao, Shanghai Jing An Qu Central Hospital No. 259 Xikang Road Shanghai 200040 ChinaChengWei Chen, Shanghai Liver Disease Research Center of the Nanjing Military Area, The 85th Hospital of PLA Shanghai ChinaWeiLun Lu, Zhongshan University No. 3 Hospital Guangzhou ChinaHong Ren, Chongqing Medical University 2nd Hospital Chongqing ChinaDeMing Tan, Xiang Ya Hospital, Central South University Department of Infectious Diseases Changsha ChinaYuMing Wang, 3rd Military Medical University So... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1750013 Sat, 30 Aug 2008 09:22:08 +0100 1750013 http://www.medworm.com/index.php?rid=1729333&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fcg14l02411053473%2F Abstract  Primary small cell carcinoma (SSC) of the liver is very rare in Japan and only ten cases have been reported worldwide. We report herein the case of a 77-year-old man with primary SCC of the liver. He had a tumor over 10 cm in diameter which was localized in the right lobe of the liver and had invaded the right diaphragm. In laboratory tests, high serum levels of lactate dehydrase and neuron-specific enolase were observed. A biopsy specimen showed that the tumor cells were similar in cytology to a pulmonary SCC. The patient was first treated with carboplatin and etoposide according to the therapy protocol for pulmonary SCC and then with a regimen using etoposid and cisplatinum, resulting in an unfavorable outcome. We discuss the clinical course and therapy of ... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1729333 Fri, 22 Aug 2008 09:50:04 +0100 1729333 http://www.medworm.com/index.php?rid=1713851&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp4xg208854071335%2F Content Type Journal ArticleDOI 10.1007/s12072-007-9037-y Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=1713851 Sun, 17 Aug 2008 13:40:51 +0100 1713851 http://www.medworm.com/index.php?rid=1704645&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fhj73733n2406h728%2F Content Type Journal ArticleCategory ErratumDOI 10.1007/s12072-008-9089-7Authors Masao Omata, The University of Tokyo Department of Gastroenterology, Graduate School of Medicine 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8655 JapanShiv Kumar Sarin, University of Delhi G. B. Pant Hospital #201, Academic Block New Delhi 110 002 India Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=1704645 Tue, 12 Aug 2008 07:32:48 +0100 1704645 http://www.medworm.com/index.php?rid=1657129&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4702n97rl61p0m61%2F We report a case of Salmonella SBP occurring in a patient with decompensated cryptogenic cirrhosis with concurrent low-grade non-Hodgkin lymphoma and prior treatment with rituximab. Physicians should be aware of the atypical presentation, especially in cirrhotic patients who are immunosuppressed. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s12072-008-9087-9Authors Harshal Rajekar, Asian Center for Liver Diseases and Transplantation Gleneagles Hospital Annexe Block #02-37, 6A Napier Road Singapore Singapore 258500Chun-Tao Wai, Asian Center for Liver Diseases and Transplantation Gleneagles Hospital Annexe Block #02-37, 6A Napier Road Singapore Singapore 258500Kang-Hoe Lee, Asian Center for Liver Diseases and Transplantation Gleneagles Hospital Annexe Block #02-37, 6A N... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1657129 Fri, 25 Jul 2008 06:55:43 +0100 1657129 http://www.medworm.com/index.php?rid=1657133&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3221470443000114%2F Abstract  Several large observational, longitudinal studies of the natural history of chronic hepatitis B (CHB) have demonstrated that high levels of hepatitis B virus (HBV) replication are associated with long-term risk of cirrhosis, decompensation, hepatocellular carcinoma, and liver-related mortality. The corollary is also true—profound and sustained suppression either spontaneously or during antiviral therapy will prevent disease progression and complications. Multiple analyses of various baseline factors and on-treatment responses have identified the absolute HBV DNA level after 24 weeks of therapy as the best predictor of long-term efficacy. Lower 24-week serum HBV DNA levels after lamivudine, telbivudine, or entecavir are associated with higher rates of mainta... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1657133 Fri, 25 Jul 2008 06:55:42 +0100 1657133 http://www.medworm.com/index.php?rid=1657132&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb01g7j23934192l7%2F Conclusion  SAM prevents alcohol-induced liver injury in rats by reducing liver lipid peroxidation, anti-inflammation, and antihyperplasia. In addition, it does not affect the plasma tHcy levels. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-008-9082-1Authors Zuojiong Gong, State Key Laboratory of Virology, Renmin Hospital of Wuhan University Department of Infectious Diseases Wuhan 430060 ChinaShaonan Yan, State Key Laboratory of Virology, Renmin Hospital of Wuhan University Department of Infectious Diseases Wuhan 430060 ChinaPing Zhang, State Key Laboratory of Virology, Renmin Hospital of Wuhan University Department of Infectious Diseases Wuhan 430060 ChinaYanqing Huang, State Key Laboratory of Virology, Renmin Hospital of Wuhan University Dep... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1657132 Fri, 25 Jul 2008 06:55:42 +0100 1657132 http://www.medworm.com/index.php?rid=1657131&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu805923583n06785%2F Conclusion  Successful treatment with LAM may reduce serum ferritin levels and improve hepatic siderosis in a subset of patients with chronic HBV infection. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-008-9084-zAuthors Shogo Ohkoshi, Graduate School of Medical and Dental Sciences of Niigata University Division of Gastroenterology and Hepatology 1-754, Asahimachi-Dori Niigata-city 951-8122 JapanAkira Yoshimura, Graduate School of Medical and Dental Sciences of Niigata University Division of Gastroenterology and Hepatology 1-754, Asahimachi-Dori Niigata-city 951-8122 JapanSatoshi Yamamoto, Graduate School of Medical and Dental Sciences of Niigata University Division of Radiology 1-754, Asahimachi-Dori Niigata-city 951-8122 JapanMasahiko Yano, G... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1657131 Fri, 25 Jul 2008 06:55:42 +0100 1657131 http://www.medworm.com/index.php?rid=1657130&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk60xt46142066623%2F Conclusion   Anti-TB-DIH is not uncommon, needs early recognition and treatment, and is more in patients with pre-existing liver disease and low BMI. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-008-9085-yAuthors Hoda A. Makhlouf, Assiut University Department of Chest Diseases, Faculty of Medicine Assiut 71111 EgyptAhmed Helmy, Assiut University Department of Tropical Medicine & Gastroenterology, Faculty of Medicine Assiut 71111 EgyptEhab Fawzy, Assiut University Department of Tropical Medicine & Gastroenterology, Faculty of Medicine Assiut 71111 EgyptMadiha El-Attar, Assiut University Department of Tropical Medicine & Gastroenterology, Faculty of Medicine Assiut 71111 EgyptHebat Alla G. Rashed, Assiut University Department of Clinical Patholo... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1657130 Fri, 25 Jul 2008 06:55:42 +0100 1657130 http://www.medworm.com/index.php?rid=1657134&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft1n6013111002133%2F Conclusions  In this large cohort of CHC patients from a single institution, AA were older at presentation, had a higher prevalence of genotype 1, but significantly lower ALT levels than NHW. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-008-9086-xAuthors Firdous A. Siddiqui, Wayne State University School of Medicine Division of Gastroenterology Detroit MI USAMurray N. Ehrinpreis, Wayne State University School of Medicine Division of Gastroenterology Detroit MI USAJames Janisse, Wayne State University School of Medicine Division of Family Medicine and Public Health Sciences Detroit MI USARavi Dhar, Wayne State University School of Medicine Division of Gastroenterology Detroit MI USAElizabeth May, Wayne State University School of Medicine Divisi... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1657134 Fri, 25 Jul 2008 06:55:41 +0100 1657134 http://www.medworm.com/index.php?rid=1488091&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5tl5803h53lw7311%2F Abstract  Ectopic varices (EcV) comprise large portosystemic venous collaterals located anywhere other than the gastro-oesophageal region. No large series or randomized-controlled trials address this subject, and therefore its management is based on available expertise and facilities, and may require a multidisciplinary team approach. EcV are common findings during endoscopy in portal hypertensive patients and their bleeding accounts for only 1–5% of all variceal bleeding. EcV develop secondary to portal hypertension (PHT), surgical procedures, anomalies in venous outflow, or abdominal vascular thrombosis and may be familial in origin. Bleeding EcV may present with anaemia, shock, haematemesis, melaena or haematochezia and should be considered in patients with PHT and gas... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1488091 Sat, 31 May 2008 07:06:06 +0100 1488091 http://www.medworm.com/index.php?rid=1481805&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft75n62n34082t831%2F Conclusions  Although the efficacy of lamivudine is limited because of breakthrough hepatitis, adefovir was used as a salvage treatment of patients with lamivudine-resistant chronic hepatitis B. In addition, lamivudine was used for the treatment of Japanese patients with chronic hepatitis B with or without lamivudine resistance, and was found to be useful regarding the long-term virologic and biochemical responses. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-008-9081-2Authors Satoshi Shakado, Fukuoka University School of Medicine The Department of Gastroenterology and Hepatology 7-45-1 Nanakuma, Jonan-ku Fukuoka 814-0180 JapanHiroshi Watanabe, Fukuoka University School of Medicine The Department of Gastroenterology and Hepatology 7-45-1 Nan... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1481805 Fri, 30 May 2008 06:00:25 +0100 1481805 http://www.medworm.com/index.php?rid=1450199&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F633706w4251m092w%2F Content Type Journal ArticleDOI 10.1007/s12072-008-9079-9 Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=1450199 Fri, 16 May 2008 05:53:49 +0100 1450199 http://www.medworm.com/index.php?rid=1436757&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fdu475u12q655175j%2F Abstract  Large amounts of new data on the natural history and treatment of chronic hepatitis B virus (HBV) infection have become available since 2005. These include long-term follow-up studies in large community-based cohorts or asymptomatic subjects with chronic HBV infection, further studies on the role of HBV genotype/naturally occurring HBV mutations, treatment of drug resistance and new therapies. In addition, Pegylated interferon α2a, entecavir and telbivudine have been approved globally. To update HBV management guidelines, relevant new data were reviewed and assessed by experts from the region, and the significance of the reported findings were discussed and debated. The earlier “Asian-Pacific consensus statement on the management of chronic hepatitis B” was r... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1436757 Sat, 10 May 2008 09:06:17 +0100 1436757 http://www.medworm.com/index.php?rid=1432332&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv822q28295h16632%2F Abstract  Increasing evidence exists that iron overload, a common finding in chronic hepatitis C virus (HCV) infection, plays an important role in the pathophysiology of this disease. The mechanisms by which iron excess induces liver damage along with the benefit of iron depletion via phlebotomy on biochemical and histological outcomes in patients with chronic HCV infection have been discussed in this review. Finally, we focus on the effect of iron reduction on the rate of response to interferon antiviral therapy. Content Type Journal ArticleCategory Review ArticleDOI 10.1007/s12072-008-9076-zAuthors Massimo Franchini, Piazzale Ludovico Scuro Servizio di Immunoematologia e Trasfusione, Centro Emofilia, Azienda Ospedaliera di Verona, Ospedale Policlinico Verona 37134 Ital... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1432332 Thu, 08 May 2008 05:51:48 +0100 1432332 http://www.medworm.com/index.php?rid=1432333&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn8tw30776j0t7080%2F Abstract  Ornithine transcarbamylase (OTC) deficiency is an X-linked urea cycle defect. While hemizygous males typically present with hyperammonemic coma in infancy, reports of rare late-onset presentations exist, with poor outcomes in males up to 58 years old. Relatives with mutations identical to affected patients often remain asymptomatic, and it is likely that environmental and genetic factors influence disease penetrance and expression. Here, we present our investigation of a patient with late-onset presentation, and we emphasize the potential role of environmental and genetic factors on disease expression. The patient was a previously healthy 62-year-old man who developed mental slowing, refractory seizures, and coma over an 8-day period. Interestingly, the patie... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1432333 Wed, 07 May 2008 14:28:57 +0100 1432333 http://www.medworm.com/index.php?rid=1417831&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl302714255605664%2F In conclusion, cost-effectiveness analysis is an important tool for health care administrators, clinicians, and patients to decide on the optimal therapy for chronic hepatitis B, but the methodology permits considerable leeway for interpretation of results, thus a combination of cost-effective indices may be needed to paint a more complete picture. Content Type Journal ArticleCategory Review ArticleDOI 10.1007/s12072-008-9049-2Authors Yock Young Dan, National University Hospital Department of Gastroenterology and Hepatology 5 Lower Kent Ridge Road Singapore 119074 SingaporeMyat Oo Aung, Centre for Molecular Medicine, Agency for Science, Technology and Research Singapore SingaporeSeng Gee Lim, National University Hospital Department of Gastroenterology and Hepatology 5 Lower Kent Ri... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1417831 Thu, 01 May 2008 05:58:41 +0100 1417831 http://www.medworm.com/index.php?rid=1417832&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc5327k2345721643%2F Abstract  Patients (85%) with hepatocellular adenoma (HCA) are women taking oral contraceptives. They can be divided into four subgroups according to their genotype/phenotype features. (1) Hepatocyte nuclear factor 1α (HNF1α) biallelic somatic mutations are observed in 35% of the HCA cases. It occurs in almost all cases in women. HNF1α-mutated HCA are most of the time, highly steatotic, with a lack of expression of liver fatty acid binding protein (LFABP) in immunohistochemistry analyses. Adenomatosis is frequently detected in this context. An HNF1α germline mutation is observed in less than 5% of HCA cases and can be associated with MODY 3 diabetes. (2) An activating β-catenin mutation was found in 10% of HCA. These β-catenin activated HCAs are observed in men and wo... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1417832 Thu, 01 May 2008 05:58:40 +0100 1417832 http://www.medworm.com/index.php?rid=1397588&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fbm605k164q039142%2F Content Type Journal ArticleDOI 10.1007/s12072-008-9069-yAuthors Stephen Locarnini, Victorian Infectious Diseases Reference Laboratory Research and Molecular Development 10 Wreckyn Street North Melbourne 3051 VIC Australia Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 Journal Volume Volume 2 Journal Issue Volume 2, Supplement 1 / May, 2008 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=1397588 Wed, 23 Apr 2008 16:18:50 +0100 1397588 http://www.medworm.com/index.php?rid=1395074&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0764572162u4007g%2F Conclusion Serum nitrate level can be used as a non-invasive predictor for progression of chronic liver disease as well as for the presence of oesophageal varices. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-008-9077-yAuthors Assem M. El-Sherif, Al-Azhar Faculty of Medicine Internal Medicine Department Nasr City Cairo EgyptMohamed A. Abou-Shady, Al-Azhar Faculty of Medicine Internal Medicine Department Nasr City Cairo EgyptAshraf M. Al-Bahrawy, Al-Azhar Faculty of Medicine Internal Medicine Department Nasr City Cairo EgyptReda M. Bakr, Al-Azhar Faculty of Medicine Internal Medicine Department Nasr City Cairo EgyptAbdel-Moneim M. Hosny, Al-Azhar Faculty of Medicine Clinical Pathology Department Nasr City Cairo Egypt Journal Hepatology InternationalOn... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1395074 Tue, 22 Apr 2008 14:22:21 +0100 1395074 http://www.medworm.com/index.php?rid=1377922&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm10037r727m62673%2F Content Type Journal ArticleCategory Others (Announcements, etc.)DOI 10.1007/s12072-008-9073-2Authors Chutima Pramoolsinsap, 32/23 Sino_-Thai Tower 14th fl Bangkok Thailand Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=1377922 Tue, 15 Apr 2008 08:04:23 +0100 1377922 http://www.medworm.com/index.php?rid=1371895&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F10142wm43247x236%2F Conclusions This study showed that propranolol has a significant hemodynamic effect only in the CCl4 model and suggested a model-dependent effect of propranolol. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-008-9070-5Authors Lionel Fizanne, Université d’Angers Laboratoire HIFIH, UPRES EA 3859, UFR de Médecine Angers FranceNicolas Régenet, Université d’Angers Laboratoire HIFIH, UPRES EA 3859, UFR de Médecine Angers FranceJianhua Wang, Université d’Angers Laboratoire HIFIH, UPRES EA 3859, UFR de Médecine Angers FranceFrédéric Oberti, Université d’Angers Laboratoire HIFIH, UPRES EA 3859, UFR de Médecine Angers FranceFrédéric Moal, Université d’Angers Laboratoire HIFIH, UPRES EA 3859, UFR de Médecine Angers FranceJerôme Roux, Universit�... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1371895 Sat, 12 Apr 2008 09:32:22 +0100 1371895 http://www.medworm.com/index.php?rid=1371894&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F986382460874v770%2F Conclusions  Pregnancy is associated with serum ALT elevation and HBeAg loss in patients with chronic HBV infection in the peri-partum period. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-008-9063-4Authors Hui-Hui Tan, Singapore General Hospital Department of Gastroenterology & Hepatology 1 Hospital Drive, Outram Road Singapore Singapore 169608Hock-Foong Lui, Singapore General Hospital Department of Gastroenterology & Hepatology 1 Hospital Drive, Outram Road Singapore Singapore 169608Wan-Cheng Chow, Singapore General Hospital Department of Gastroenterology & Hepatology 1 Hospital Drive, Outram Road Singapore Singapore 169608 Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=1371894 Sat, 12 Apr 2008 09:32:22 +0100 1371894 http://www.medworm.com/index.php?rid=1366592&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft26160831v588518%2F Abstract  Hepatitis E is an emerging disease in resource-poor regions of the world. It is estimated that about 2 billion people live in areas endemic for this disease. The inability to reproducibly culture hepatitis E virus makes it impossible to develop traditional live or inactivated vaccines. However, significant progress has been made in developing and testing recombinant subunit vaccines based on the viral capsid protein. This review summarizes these efforts. Content Type Journal ArticleCategory Review ArticleDOI 10.1007/s12072-008-9071-4Authors Rakesh Aggarwal, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS) Department of Gastroenterology Rae Bareilly Road Lucknow 226 014 IndiaShahid Jameel, International Centre for Genetic Engineering and Bi... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1366592 Thu, 10 Apr 2008 06:51:32 +0100 1366592 http://www.medworm.com/index.php?rid=1366591&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb66l438060nutn02%2F Abstract  Concurrent hepatitis C virus (HCV), hepatitis delta virus (HDV), or human immunodeficiency virus (HIV) infection with chronic hepatitis B virus (HBV) appears to increase the risk of progressive liver disease including liver cirrhosis and hepatocellular carcinoma. There is a 10% prevalence of HCV infection in chronic HBV or HDV infection. Serological evidence of previous exposure to HBV is found in more than 80% of HIV-positive patients in the high risk group. Notably, the most recently acquired virus tends to suppress the pre-existing virus. In chronic HBV infection acquired perinatally or in early childhood, usually HCV is dominant and may suppress or even displace HBV and HDV. Less frequently, HBV or HDV suppresses HCV. It is generally agreed that the dominant v... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1366591 Thu, 10 Apr 2008 06:51:32 +0100 1366591 http://www.medworm.com/index.php?rid=1364884&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9j73p7w448582175%2F Conclusions  TGF-α mRNA is an early predictor of FH outcome and a sensitive biomarker of lower regenerative liver capacity. This assay could help facilitate early therapy choice, such as liver transplantation. Content Type Journal ArticleCategory ORIGINAL ARTICLEDOI 10.1007/s12072-008-9053-6Authors Norimasa Miura, Tottori University Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine Nishicho 86 Yonago Tottori 683-8503 JapanHiroko Kabashima, Tottori University Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine Nishicho 86 Yonago Tottori 683-8503 JapanMika Shimizu, Tottori University Division of Pharmacotherapeutics, Department of Pathophysiological a... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1364884 Wed, 09 Apr 2008 05:59:24 +0100 1364884 http://www.medworm.com/index.php?rid=1362367&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F201678xm50378154%2F Abstract  An 80-year-old man was admitted to our hospital because of the rupture of the liver. Laboratory data showed iron-deficiency anemia, although there was no liver dysfunction. A computed tomography scan showed large liver tumor with intraperitoneal hemorrhage, and since a serum level of α-fetoprotein (AFP) was extremely high, we initially suspected a rupture of hepatocellular carcinoma (HCC). Transarterial embolization was performed to stop bleeding from the tumor, followed by an endoscopic examination that revealed advanced gastric cancer. Histological analysis revealed that both the gastric and the hepatic tumors were moderately to poorly differentiated adenocarcinoma, as well as that both tumors were immunohistochemically positive for AFP. Finally, we diagnosed A... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1362367 Tue, 08 Apr 2008 06:59:13 +0100 1362367 http://www.medworm.com/index.php?rid=1362366&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Faj66k6520m787g05%2F Content Type Journal ArticleCategory EditorialDOI 10.1007/s12072-008-9057-2Authors Roman E. Perri, Vanderbilt University Medical Center Division of Gastroenterology and Hepatology 21st Avenue South and Garland Avenue Nashville TN 37232 USAVijay H. Shah, Mayo Clinic GI Research Unit and Fiterman Center for Digestive Disease Rochester MN USA Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=1362366 Tue, 08 Apr 2008 06:59:13 +0100 1362366 http://www.medworm.com/index.php?rid=1336249&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fdw1867842rv0hkq7%2F Abstract  Antiviral resistance is now the single most important factor in treatment failure using nucleos(t)ide analogues (NA). Primary drug resistance mutations refer to amino acid change(s) that result in reduced susceptibility to an antiviral agent. Secondary compensatory mutations restore replication defects associated with primary drug resistance and may be associated with low level reduced susceptibility. Several evolutionary pathways of drug resistant HBV have been observed in patients treated with NAs. It is possible that the drug resistance mutations selected with one agent may affect the efficacy of other NAs. Several major HBV-evolutionary NA-resistance pathways (rtM204I/V, rtN236T and rtA181T/V) have now been characterised. The rtM204V/I pathway is responsible f... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1336249 Fri, 28 Mar 2008 08:44:44 +0100 1336249 http://www.medworm.com/index.php?rid=1331307&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk5l61w57v4808616%2F Conclusions TLR3 expression by biliary epithelial cells increased at sites of ductular reaction in diseased livers; further study will be necessary to characterize it’s in vivo physiological role. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-008-9055-4Authors Minoru Nakamura, National Hospital Organization (NHO) Nagasaki Medical Center Clinical Research Center Kubara 2-1001-1 Omura, Nagasaki 856-8562 JapanKenji Funami, Hokkaido University Graduate School of Medicine Department of Microbiology and Immunology Sapporo JapanAtsumasa Komori, National Hospital Organization (NHO) Nagasaki Medical Center Clinical Research Center Kubara 2-1001-1 Omura, Nagasaki 856-8562 JapanTerufumi Yokoyama, National Hospital Organization (NHO) Nagasaki Medical Center Clinical R... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1331307 Wed, 26 Mar 2008 15:03:02 +0100 1331307 http://www.medworm.com/index.php?rid=1307621&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm22g67264u567341%2F Conclusion  It was very important to treat the intrahepatic tumor because its worsening was still the major cause of death. The progressive treatment for pulmonary metastases may also be advised for possible prolongation of survival. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-008-9052-7Authors Shu-Min Zhang, Fudan University Department of Radiation Oncology, Zhongshan Hospital Shanghai ChinaZhao-Chong Zeng, Fudan University Department of Radiation Oncology, Zhongshan Hospital Shanghai ChinaZhao-You Tang, Fudan University Liver Cancer Institute, Zhongshan Hospital Shanghai ChinaJing Sun, Fudan University Department of Radiation Oncology, Zhongshan Hospital Shanghai ChinaJie-Min Cheng, Fudan University Department of Radiology, Zhongshan Hospit... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1307621 Sat, 15 Mar 2008 09:15:56 +0100 1307621 http://www.medworm.com/index.php?rid=1287786&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq062546061pj6051%2F Content Type Journal ArticleCategory Others (Announcements, etc.)DOI 10.1007/s12072-008-9068-zAuthors Kwang-Hyub Han, Yonsei University College of Medicine, Liver Cirrhosis Clinical Research Center Department of Internal Medicine Seoul KoreaDo Young Kim, Yonsei University College of Medicine, Liver Cirrhosis Clinical Research Center Department of Internal Medicine Seoul Korea Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=1287786 Thu, 06 Mar 2008 16:46:02 +0100 1287786 http://www.medworm.com/index.php?rid=1287787&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg364568363311730%2F This article reviews current knowledge regarding the natural history and treatment of chronic hepatitis B in children. Factors that affect the natural history of HBV infection in children are also reviewed. Content Type Journal ArticleCategory ORIGINAL ARTICLEDOI 10.1007/s12072-008-9050-9Authors Mei-Hwei Chang, National Taiwan University Hospital Division of Gastroenterology and Hepatology, Department of Pediatrics No. 7, Chung-Shan S. Road Taipei Taiwan Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=1287787 Thu, 06 Mar 2008 16:46:01 +0100 1287787 http://www.medworm.com/index.php?rid=1284716&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F01k4581303255628%2F Abstract  The natural course of hepatitis B virus (HBV) infection is variable, and chronic hepatitis B (CHB) disease exhibits itself through a spectrum of clinical manifestations. These factors contribute to the challenges faced when managing patients who live with HBV infection. Furthermore, conventional treatment options (e.g., interferon alfa-2a, lamivudine, and adefovir) are moderately effective and can be associated with problems, such as poor tolerability (interferon alfa-2a) and the development of drug resistance (lamivudine). Over the last 5 years, several antiviral agents including entecavir, peginterferon alfa-2a, and telbivudine which are more efficacious and have improved tolerability over previous drugs have become available. The availability of novel anti... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1284716 Wed, 05 Mar 2008 07:52:20 +0100 1284716 http://www.medworm.com/index.php?rid=1284717&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy761302354w65633%2F Abstract  Hepatitis due to hepatitis B virus reactivation after cytotoxic or immunosuppressive therapy is a serious cause of liver-related morbidity and mortality. With the characterization of the underlying pathogenesis, much progress in the management of this important clinical problem has been made in the past 2 decades. By year 2008, it is mandatory to screen for hepatitis B surface antigen status before initiating intensive chemotherapy or immunosuppressive therapy. All those who are hepatitis B surface antigen positive should be started on preemptive nucleos(t)ide analogues. However, there remains important issues, such as the type and duration of nucleos(t)ide analogue therapy, which need to be understood. As not all hepatitis B surface antigen-positive patients will... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1284717 Wed, 05 Mar 2008 07:52:18 +0100 1284717 http://www.medworm.com/index.php?rid=1282191&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu86266272m5972u1%2F Abstract  Alanine aminotransferase (ALT) levels have traditionally been used for treatment decisions in chronic hepatitis B virus (CHBV) infected patients. But recent data have raised doubts on this wisdom, as a significant proportion of CHBV infected patients with normal ALT have high HBVDNA levels and significant liver injury at presentation especially in areas of intermediate to high endemicity. A normal ALT value only identifies patients less likely to respond to current treatments, rather than patients who are not in need of the treatment. Patients with CHBV infection with normal ALT should be considered for treatment based on the HBV DNA levels and histological injury. Content Type Journal ArticleCategory Review articleDOI 10.1007/s12072-008-9065-2Authors Shiv Kum... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1282191 Tue, 04 Mar 2008 08:48:35 +0100 1282191 http://www.medworm.com/index.php?rid=1282192&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb055058016152188%2F Abstract  Forty years ago in 1967, Professor Blumberg discovered the Australian Antigen, later known as the hepatitis B surface antigen, and was awarded the Nobel Prize. This discovery enables the diagnosis of hepatitis B virus (HBV) infection and defines its epidemiology. Viral hepatitis B infection affects global health situation, and chronic hepatitis B (CHB) is particularly serious in the Asia-Pacific region. HBV vaccines created the first breakthrough in HBV prevention. Through universal HBV vaccination program for the newborns, promoted since the mid-1980s, the main route that perpetuates chronic infection from mother to child is curbed. Most children and young adults now have immunity against HBV infection. The next breakthrough comes with therapy for CHB. This preve... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1282192 Tue, 04 Mar 2008 08:48:34 +0100 1282192 http://www.medworm.com/index.php?rid=1282193&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft5035115728x5324%2F Abstract  The primary aim of immunomodulator therapy is to help the natural human immune system to mount a defense against hepatitis B virus. IFN-α has been used for the treatment of HBeAg-positive and HBeAg-negative chronic hepatitis B for over two decades and has been shown to be effective in suppressing HBV replication and in inducing serological response leading to long-term clinical benefits. IFN-α has been used in patients with well-compensated cirrhosis with comparable or better response to that in non-cirrhotic patients. IFN-α therapy in patients with cirrhosis has a similar side effect profile as in those without cirrhosis. However, IFN-α is contraindicated in patients with overt or decompensated cirrhosis. Pegylated IFN-α has been shown to be effective in tre... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1282193 Tue, 04 Mar 2008 08:48:33 +0100 1282193 http://www.medworm.com/index.php?rid=1269539&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy208846566273047%2F Conclusions  Our results suggest that for LAM-resistant HBV, TDF, alone or combined with LAM exerts greater viral reduction than ADV. However, no difference in HBeAg loss was observed. It appears that stronger HBV DNA reduction may not necessarily accelerate HBeAg loss. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-008-9045-6Authors Hie-Won Hann, Thomas Jefferson University Hospital Liver Disease Prevention Center, Division of Gastroenterology and Hepatology, Department of Medicine Philadelphia PA 19107-5587 USAHee Bok Chae, Thomas Jefferson University Hospital Liver Disease Prevention Center, Division of Gastroenterology and Hepatology, Department of Medicine Philadelphia PA 19107-5587 USAStephen R. Dunn, Thomas Jefferson University Hospital ... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1269539 Thu, 28 Feb 2008 15:51:39 +0100 1269539 http://www.medworm.com/index.php?rid=1269541&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ffl3j222463314028%2F Conclusion  Three months of Pentoxifylline treatment in combination with diet and exercise results in significantly greater reduction in AST levels in patients with NASH as compared with controls. Content Type Journal ArticleCategory NASH (NAFLD), PHT, Hepatic Failure and OthersDOI 10.1007/s12072-008-9058-1Authors Yin-Mei Lee, National University Hospital Department of Gastroenterology/Hepatology 5 Lower Kent Ridge Road Singapore 119074 SingaporeDede S. Sutedja, National University Hospital Department of Gastroenterology/Hepatology 5 Lower Kent Ridge Road Singapore 119074 SingaporeChun-Tao Wai, Gleneagles Hospital Asia Center for Liver Disease and Transplantation 6A Napier Road Singapore 258500 SingaporeYock-Young Dan, National University Hospital Department of Gastroen... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1269541 Thu, 28 Feb 2008 15:51:38 +0100 1269541 http://www.medworm.com/index.php?rid=1269540&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7u65117x2268w226%2F Conclusions  NAFLD is common in the DGH and should be considered in all patients with metabolic risk factors. A liver biopsy should be considered in those with low platelets, type II diabetes mellitus, and the metabolic syndrome. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-008-9044-7Authors Wing-Kin Syn, Princess Royal Hospital Apley Castle, Telford Shropshire TF1 6TF UKPeter Nightingale, Wellcome Trust Clinical Research Facility Birmingham UKJeffrey M. Bateman, Princess Royal Hospital Apley Castle, Telford Shropshire TF1 6TF UK Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=1269540 Thu, 28 Feb 2008 15:51:38 +0100 1269540 http://www.medworm.com/index.php?rid=1269542&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx781935x44r276n0%2F Conclusions  Metabolic profiles of chronic hepatitis C patients are affected by age, gender, serum adiponectin, and ALT levels. Further longitudinal studies are needed to clarify the complex interplay between HCV infection and metabolic profiles. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-008-9064-3Authors Ching-Sheng Hsu, Buddhist Tzu Chi General Hospital Division of Gastroenterology Taipei Branch Taipei Taiwan, ROCChun-Jen Liu, National Taiwan University College of Medicine and National Taiwan University Hospital Department of Internal Medicine Taipei Taiwan, ROCChen-Hua Liu, National Taiwan University College of Medicine and National Taiwan University Hospital Department of Internal Medicine Taipei Taiwan, ROCChi-Ling Chen, National Taiwa... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1269542 Thu, 28 Feb 2008 15:51:37 +0100 1269542 http://www.medworm.com/index.php?rid=1265088&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fnhm58q175m874270%2F Conclusions  ALD patients have a higher degree of redox imbalance as compared with NAFLD patients Content Type Journal ArticleCategory NASH (NAFLD), PHT, Hepatic Failure and OthersDOI 10.1007/s12072-008-9060-7Authors Payal Bhardwaj, All India Institute of Medical Sciences Department of Gastroenterology and Human Nutrition Unit New Delhi 110029 IndiaKaushal Madan, All India Institute of Medical Sciences Department of Gastroenterology and Human Nutrition Unit New Delhi 110029 IndiaSandeep Thareja, All India Institute of Medical Sciences Department of Gastroenterology and Human Nutrition Unit New Delhi 110029 IndiaYogendra Kumar Joshi, All India Institute of Medical Sciences Department of Gastroenterology and Human Nutrition Unit New Delhi 110029 IndiaAnoop Saraya, All Indi... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1265088 Wed, 27 Feb 2008 15:42:41 +0100 1265088 http://www.medworm.com/index.php?rid=1265087&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe14j30500j725107%2F Abstract  Acute and chronic infection with hepatitis B virus (HBV) is associated with an increased risk of developing liver disease including cirrhosis, decompensated liver disease, and hepatocellular carcinoma. The clinical presentation and natural history of HBV infection is mediated through complex interactions between the virus and the host immune response. HBV is not directly cytopathic to heptocytes; however, the interaction between the virus and the host immune response plays a central role in the pathogenesis of necroinflammation and liver fibrosis. Emerging data from immunopathogenesis studies in animal models and in vitro studies of liver biopsies from patients with chronic hepatitis B demonstrate a potentially important interaction between hepatitis B e antigen, ... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1265087 Wed, 27 Feb 2008 15:42:41 +0100 1265087 http://www.medworm.com/index.php?rid=1265086&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F623w6w9278148416%2F We report the characteristics of 5 children with advanced hepatic fibrosis and cirrhosis due to NAFLD. Four of them were obese, and all of them had high alanine transaminase levels and ultrasonographic evidence of fatty liver. None had diabetes mellitus or hyperlipidemia. The calculated HOMA-IR was more than two in all five cases. Liver biopsy showed stage III fibrosis in 2 patients and stage IV fibrosis (cirrhosis) in 3. Content Type Journal ArticleCategory NASH (NAFLD), PHT, Hepatic Failure and OthersDOI 10.1007/s12072-008-9062-5Authors S. Rajindrajith, University of Kelaniya Department of Paediatrics, Faculty of Medicine Thalagolla Road Ragama Sri LankaA. S. Dassanayake, University of Kelaniya Department of Pharmacology, Faculty of Medicine Thalagolla Road Ragama Sri LankaJ. Hew... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1265086 Wed, 27 Feb 2008 15:42:41 +0100 1265086 http://www.medworm.com/index.php?rid=1265085&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw415531823532038%2F Conclusion  The cost of HCC surveillance program is exorbitant for India (gross national income per capita US$ 620) and possibly other low/middle income countries. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-008-9054-5Authors Shashi Bala Paul, All India Institute of Medical Sciences Department of Radio-diagnosis New Delhi 110029 IndiaVishnubhatla Sreenivas, All India Institute of Medical Sciences Department of Biostatistics New Delhi 110029 IndiaManpreet Singh Gulati, All India Institute of Medical Sciences Department of Radio-diagnosis New Delhi 110029 IndiaKaushal Madan, All India Institute of Medical Sciences Department of Gastroenterology New Delhi 110029 IndiaArun Kumar Gupta, All India Institute of Medical Sciences Department of Radio-d... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1265085 Wed, 27 Feb 2008 15:42:39 +0100 1265085 http://www.medworm.com/index.php?rid=1231773&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw4001n4w77788103%2F Abstract  New standardized assays for the quantification of hepatitis B virus (HBV) DNA have yielded insights into the association of HBV DNA levels with the relative risk of developing liver disease. Quantification of HBV DNA has also played a role in the management of chronic hepatitis B by allowing criteria to be established for determining patient eligibility for antiviral therapy, monitoring response, and identifying the development of resistance. In addition to serum HBV DNA levels, the HBV genotype may influence disease progression and response to therapy. However, many of the studies that have included genotype assessment do not compare across the range of genotypes, and current management guidelines do not incorporate genotype determination. More recently, quantita... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1231773 Wed, 13 Feb 2008 16:09:31 +0100 1231773 http://www.medworm.com/index.php?rid=1215204&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fkl3344452m6w0805%2F Conclusions  In conclusion, a finite course of peginterferon alfa-2a provides significant and sustained treatment benefit in Asian CHB patients, who have traditionally been regarded as difficult to treat. Content Type Journal ArticleCategory ORIGINAL ARTICLEDOI 10.1007/s12072-007-9022-5Authors Teerha Piratvisuth, Prince of Songkla University Department of Internal Medicine, NKC Institute of Gastroenterology and Hepatology, Songklanagarind Hospital Hat Yai Songkla 90110 ThailandGeorge Lau, Queen Mary Hospital Department of Medicine Hong Kong ChinaYou-Chen Chao, Tri-Service General Hospital Division of Gastroenterology and Hepatology Taipei TaiwanRui Jin, Beijing You-An Hospital Digestive Department Beijing ChinaAnuchit Chutaputti, Pramongkutklao Hospital Section of Diges... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1215204 Tue, 05 Feb 2008 15:46:25 +0100 1215204 http://www.medworm.com/index.php?rid=1191304&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy62672785768557p%2F Conclusion  Our results showed that even a single heat treatment could induce further transformation of an HCC cell line. Our results suggest that an insufficient treatment of HCC by RFA that enables survival of some cells might induce further malignant transformation in vivo. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-007-9040-3Authors Koichi Obara, St. Marianna University School of Medicine Division of Gastroenterology and Hepatology 2-16-1 Sugao, Miyamae-ku Kawasaki City Kanagawa 216-8511 JapanNobuyuki Matsumoto, St. Marianna University School of Medicine Division of Gastroenterology and Hepatology 2-16-1 Sugao, Miyamae-ku Kawasaki City Kanagawa 216-8511 JapanMasaru Okamoto, St. Marianna University School of Medicine Division of Gas... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1191304 Tue, 29 Jan 2008 15:45:09 +0100 1191304 http://www.medworm.com/index.php?rid=1155773&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa85816781168919j%2F Content Type Journal ArticleCategory ErratumDOI 10.1007/s12072-007-9043-0Authors Guangbi Yao, Shanghai Jing An Qu Central Hospital No. 259 Xikang Rd Shanghai 200040 ChinaChengwei Chen, Shanghai Liver Disease Center of Nangjing Military Command Shanghai ChinaWeilun Lu, No. 3 Hospital Affiliated to Sun Yat-Sen University Guangzhou ChinaHong Ren, No. 2 Hospital Affiliated to Chongqing Medical University Chongqing ChinaDeming Tan, Infectious Disease Department of Xiang Ya Hospital Changsha ChinaYuming Wang, Xinan Hospital Chongqing ChinaDaozheng Xu, Beijing Di Tan Hospital Beijing ChinaZhengrong Jiang, Shanghai Roche Pharmaceutical Company Shanghai ChinaJessica Liu, Pharmaceutical Research Institution Bristol-Myers Squibb Company Braine-l’Alleud BelgiumDong Xu, Bristol-Myers Squibb Compa... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1155773 Mon, 14 Jan 2008 23:23:04 +0100 1155773 http://www.medworm.com/index.php?rid=1146153&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd6l1225t38733451%2F Conclusions  The study demonstrated no evidence that zinc ameliorates hematologic side effects, improves liver function, and enhances the response to the therapy in chronic hepatitis C receiving PEG-IFN-α2b plus RBV. Content Type Journal ArticleDOI 10.1007/s12072-007-9029-yAuthors Ke Ih Kim, Kobe Asahi Hospital Department of Pharmacy 3-5-25, Bououji-cho, Nagata-ku Kobe Hyogo 653-0801 JapanSoo Ryang Kim, Kobe Asahi Hospital Department of Gastroenterology Kobe JapanNoriko Sasase, Kobe Asahi Hospital Department of Pharmacy 3-5-25, Bououji-cho, Nagata-ku Kobe Hyogo 653-0801 JapanYoko Akimoto, Kobe Asahi Hospital Department of Pharmacy 3-5-25, Bououji-cho, Nagata-ku Kobe Hyogo 653-0801 JapanMao Shikata, Kobe Asahi Hospital Department of Pharmacy 3-5-25, Bououji-cho, Nagata-... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1146153 Fri, 11 Jan 2008 16:24:18 +0100 1146153 http://www.medworm.com/index.php?rid=1126077&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw147t5664061vv46%2F Conclusions Diagnostic accuracy of AFP in small HCC was substantially limited. Surveillance including other tumor markers with optimal cutoff value should be conducted to confirm the efficacy of the policy. Content Type Journal ArticleCategory ORIGINAL ARTICLEDOI 10.1007/s12072-007-9038-xAuthors Ryosuke Tateishi, University of Tokyo Department of Gastroenterology, Graduate School of Medicine 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8655 JapanHaruhiko Yoshida, University of Tokyo Department of Gastroenterology, Graduate School of Medicine 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8655 JapanYutaka Matsuyama, University of Tokyo Department of Biostatistics, Graduate School of Medicine 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8655 JapanNorio Mine, University of Tokyo Department of Gastroenterology, Graduate Scho... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1126077 Mon, 31 Dec 2007 20:29:51 +0100 1126077 http://www.medworm.com/index.php?rid=1121679&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj20003p47x477165%2F Conclusion  These results demonstrate that bone marrow transplants cannot maintain disease correction in a mouse model of mild hepatic damage, although initial copper metabolism correction was observed. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-007-9039-9Authors Nicole E. Buck, University of Melbourne Murdoch Childrens Research Institute, Royal Children’s Hospital, Department of Paediatrics Flemington Road Parkville VIC 3052 AustraliaDaphne M. Y. Cheah, University of Melbourne Murdoch Childrens Research Institute, Royal Children’s Hospital, Department of Paediatrics Flemington Road Parkville VIC 3052 AustraliaNgaire J. Elwood, University of Melbourne Childrens Cancer Centre, Murdoch Childrens Research Institute, Royal Children’s Hospi... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1121679 Fri, 28 Dec 2007 16:16:46 +0100 1121679 http://www.medworm.com/index.php?rid=1116110&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk7q575g165658771%2F Conclusions  A single injection of AAV vector containing HGF gene achieved long-term expression of HGF and resulted in resolution of mouse liver fibrosis. HGF gene therapy mediated by AAV is feasible for the treatment of liver fibrosis. Content Type Journal ArticleCategory ORIGINAL ARTICLEDOI 10.1007/s12072-007-9042-1Authors Kazuhiro Suzumura, Hyogo College of Medicine First Department of Surgery 1-1 Mukogawacho Nishinomiya Hyogo 663-8501 JapanTadamichi Hirano, Hyogo College of Medicine First Department of Surgery 1-1 Mukogawacho Nishinomiya Hyogo 663-8501 JapanGakuhei Son, Hyogo College of Medicine First Department of Surgery 1-1 Mukogawacho Nishinomiya Hyogo 663-8501 JapanYuji Iimuro, Hyogo College of Medicine First Department of Surgery 1-1 Mukogawacho Nishinomiya Hy... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1116110 Mon, 24 Dec 2007 17:34:59 +0100 1116110 http://www.medworm.com/index.php?rid=1106140&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr10976pn7v864232%2F Abstract  A small-cell carcinoma of the extrahepatic bile duct in a 69-year-old woman is herein reported. A tumor measuring approximately 3 cm in diameter was located at the confluence of the common bile duct, cystic duct, and common hepatic duct. Histopathologically, the tumor was small-cell neuroendocrine carcinoma without any gland formation or differentiation to squamous cell carcinoma. Tumor cells were immunoreactive for epithelial markers such as epithelial membrane antigen and cytokeratin and for the neuroendocrine markers such as neuron-specific enolase, chromogranin A, and synaptophysin. Although the carcinomas in more than half of the reported cases have been reported to be associated with well-to-moderately differentiated squamous or glandular components, se... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1106140 Tue, 18 Dec 2007 15:49:29 +0100 1106140 http://www.medworm.com/index.php?rid=1100039&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj65192214306mq57%2F Conclusion  Cirrhosis with HCC, clinical splenomegaly, hemodynamic instability, a previous history of GEVH, thrombocytopenia (i.e., platelet count <91,000), and splenic size ≥158 mm are independent noninvasive predictors of large varices in patients hospitalized with gastroesophageal variceal hemorrhage. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-007-9034-1Authors Faisal Wasim Ismail, Aga Khan University Hospital Section of Gastroenterology, Department of Medicine Karachi 74800 PakistanHasnain A. Shah, Aga Khan University Hospital Section of Gastroenterology, Department of Medicine Karachi 74800 PakistanSaeed Hamid, Aga Khan University Hospital Section of Gastroenterology, Department of Medicine Karachi 74800 PakistanZaigham Abbas... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1100039 Sat, 15 Dec 2007 19:42:35 +0100 1100039 http://www.medworm.com/index.php?rid=1100038&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft0w986665m415264%2F Conclusion  The present study provides evidence that female gender provides a distinct survival advantage over males in unresectable HCC presenting with similar tumor characteristics, liver function, and coexisting liver disease. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-007-9041-2Authors Shama C. Buch, University of Pittsburgh Center for Clinical Pharmacology Philadelphia PA USAVenkateswarlu Kondragunta, Duke University Durham NC USARobert A. Branch, University of Pittsburgh Center for Clinical Pharmacology Philadelphia PA USABrian I. Carr, Thomas Jefferson University Liver Cancer Program, Kimmel Cancer Center Bluemle Building, Room 1002, 233 S.10th Street Philadelphia PA 19107 USA Journal Hepatology InternationalOnline ISSN 1936-05... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1100038 Sat, 15 Dec 2007 19:42:35 +0100 1100038 http://www.medworm.com/index.php?rid=1097184&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp31v56884106l034%2F Abstract Purpose  Late-stage outcomes of chronic hepatitis B virus (HBV) infection, including fibrosis, cirrhosis, and hepatocellular carcinoma (HCC) result from persistent liver injury mediated by HBV antigen specific cytotoxic T lymphocytes (CTLs). Two other outcomes that often accompany chronic infection, the emergence of mutant viruses, including HBe-antigen negative (HBeAg (−)) HBV, and a reduction over time in the fraction of hepatocytes productively infected with HBV, may also result from persistent immune attack by antiviral CTLs. To gain insights into how these latter changes take place, we employed computer simulations of the chronically infected liver. Methods  Computational programs were used to model the emergence of both virus-free hepatocyt... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1097184 Fri, 14 Dec 2007 15:57:47 +0100 1097184 http://www.medworm.com/index.php?rid=1074884&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fwh24q95931434141%2F Content Type Journal ArticleCategory EditorialDOI 10.1007/s12072-007-9036-zAuthors Eugene R. Schiff, University of Miami Miller School of Medicine Center for Liver Diseases Miami FL USA Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=1074884 Wed, 05 Dec 2007 16:37:19 +0100 1074884 http://www.medworm.com/index.php?rid=1062741&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj086328u57567746%2F Abstract  Actinomycotic hepatic abscess was diagnosed in a 46-year-old male driver from Ukraine presenting with the symptoms of malaise, loss of appetite, upper right quadrant pain, weight loss, and night sweats which had been present for last 2 months. Computed tomography (CT) of the abdomen revealed a hypodense mass in the left liver lobe which was suspected as hepatocellular carcinoma. Histopathological examination of the CT guided biopsy specimen yielded a diagnosis of actinomycotic abscess of the liver. Treatment with intravenous penicillin for 6 weeks followed by a course of oral penicillin for 14 weeks resulted in complete cure as evidenced by clinical improvement and radiological disappearance of the lesion. Content Type Journal ArticleCategory Repo... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1062741 Thu, 29 Nov 2007 16:39:31 +0100 1062741 http://www.medworm.com/index.php?rid=1057243&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F254340671676675r%2F Abstract  The bone marrow contains stem cells that have the potential to differentiate into a variety of organ-specific mature cells, including the liver and the pancreas. Recently, the origin of hepatic progenitors and hepatocytes was identified to be the bone marrow. However, evidence that describes which cells, among all bone marrow cells, differentiate into hepatocytes, has not yet been presented. Based on recent reports, hematopoietic and hepatic stem cells share characteristic markers such as CD34, c-kit, and Thy1. In particular, both hematopoietic and hepatic stem cells express the Thy1 antigen. We investigated whether rat Thy1-positive bone marrow cells express liver-specific genes in vitro, and whether transplanted Thy1 BM cells differentiate into mature hepat... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1057243 Tue, 27 Nov 2007 15:43:19 +0100 1057243 http://www.medworm.com/index.php?rid=1057242&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr50q00360162gt71%2F Abstract  Prediction of mortality of patients with cirrhosis of liver, a common and potentially fatal disease, is important for timely listing of patients for liver transplantation. The Child–Pugh scoring system has been widely used for predicting the outcome of liver cirrhosis. The Model for End-Stage Liver Disease (MELD) score has recently become popular for prediction of short-term mortality for organ allocation. A few studies that evaluated artificial neural network (ANN)-based model for prediction of outcome of cirrhosis of liver in terms of mortality have consistently shown it to be superior to Child–Pugh scoring and logistic regression-based models; it is worth noting that MELD score is also derived using the logistic regression model. Due to the inherent ability... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1057242 Tue, 27 Nov 2007 15:43:19 +0100 1057242 http://www.medworm.com/index.php?rid=1057244&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh557k2mn981x6372%2F Conclusions  HCD-fed laboratory animals provide a model of early non-alcoholic fatty liver disease resembling the disease in humans. The genome wide gene profiling of the liver reveals the complexity of the disease, unravels novel aspects of HCD-induced hepatic steatosis, and helps elucidate its nature and mechanisms. Content Type Journal ArticleCategory Original ResearchDOI 10.1007/s12072-007-9025-2Authors Ion V. Deaciuc, University of Louisville School of Medicine Division of Gastroenterology/Hepatology, Department of Medicine 550 S. Jackson Street, ACB Bldg., Third Floor Louisville KY 40202 USAZhenyuan Song, University of Louisville School of Medicine Division of Gastroenterology/Hepatology, Department of Medicine 550 S. Jackson Street, ACB Bldg., Third Floor Louisv... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1057244 Tue, 27 Nov 2007 15:43:18 +0100 1057244 http://www.medworm.com/index.php?rid=1057245&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8vh54816297vl2t7%2F Conclusions  Regulated expression of Ep-CAM supported proliferation in fetal hepatoblasts through weak adhesion and helped in biliary morphogenesis by promoting stronger adhesion in hepatoblasts during this process. Restriction of Ep-CAM expression to bile ducts in the adult liver presumably facilitated sequestration of stem/progenitor cells. This stage-specific and cell compartment-related regulation of adhesion molecules should be relevant for defining how liver stem/progenitor cells enter, exit, and remain in hepatic niches during both health and disease. Content Type Journal ArticleCategory Original ResearchDOI 10.1007/s12072-007-9023-4Authors Mari Inada, Albert Einstein College of Medicine Departments of Medicine and Pathology, Marion Bessin Liver Research Cente... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1057245 Tue, 27 Nov 2007 15:38:13 +0100 1057245 http://www.medworm.com/index.php?rid=1047548&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F22w2702215645931%2F Conclusions  Patients awaiting liver transplantation are not experiencing worse physical and psychological HRQoL than other liver patients with cirrhosis of the liver. Therefore, there is currently no indication to increase the level of psychosocial care for liver transplant candidates. Content Type Journal ArticleDOI 10.1007/s12072-007-9035-0Authors Jolie J. Gutteling, Erasmus MC Department of Gastroenterology and Hepatology ’s Gravendijkwal 230 3015 CE Rotterdam The NetherlandsRobert A. de Man, Erasmus MC Department of Gastroenterology and Hepatology ’s Gravendijkwal 230 3015 CE Rotterdam The NetherlandsJan J. V. Busschbach, Erasmus MC Department of Medical Psychology and Psychotherapy Dr. Molewaterplein 50 3015 GE Rotterdam The NetherlandsAnne-Sophie E. Darlingt... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1047548 Wed, 21 Nov 2007 16:42:01 +0100 1047548 http://www.medworm.com/index.php?rid=1030075&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy6u85230385482x5%2F Conclusions  Iodized oil accumulation and retention in the hypovascular portion of early-stage HCC was frequently observed after ultraselective TACE, mainly in the hypovascular portion with decreased portal blood. Content Type Journal ArticleCategory Original ResearchDOI 10.1007/s12072-007-9030-5Authors Shiro Miyayama, Fukuiken Saiseikai Hospital Department of Diagnostic Radiology 7-1, Funabashi, Wadanaka-cho Fukui 918-8503 JapanOsamu Matsui, Kanazawa University Department of Radiology, Graduate School of Medical Science 13-1, Takara-machi Kanazawa 920-8641 JapanMasashi Yamashiro, Fukuiken Saiseikai Hospital Department of Diagnostic Radiology 7-1, Funabashi, Wadanaka-cho Fukui 918-8503 JapanYasuji Ryu, Fukuiken Saiseikai Hospital Department of Diagnostic Radiology 7-1, ... Hepatology International journals http://www.medworm.com/rss/comments.php?id=1030075 Wed, 14 Nov 2007 15:31:36 +0100 1030075