Hepatology International via MedWorm.com MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Hepatology International' source. Wed, 08 Feb 2012 18:15:41 +0100 Circulating endotoxin and interleukin-6 levels are associated with Doppler-evaluated pulmonary vascular resistance in cirrhotic patients http://www.medworm.com/index.php?rid=5668199&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl2xqk46271598g48%2F Conclusions  Our results suggest that endotoxin and IL-6 may contribute to cirrhosis-associated PH. In this regard, modulation of these substances could improve pulmonary pressures in cirrhotic patients. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s12072-011-9337-0Authors Georgios N. Kalambokis, First Division of Internal Medicine and Hepato-Gastroenterology Unit, Medical School of Ioannina, University Hospital, 45110 Ioannina, GreeceAthanasia Mouzaki, Division of Hematology, Department of Internal Medicine, Medical School, University of Patras, Patras, GreeceMaria Rodi, Division of Hematology, Department of Internal Medicine, Medical School, University of Patras, Patras, GreeceKonstantinos Pappas, Department of Cardiology, University Hos... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5668199 Thu, 02 Feb 2012 06:55:50 +0100 5668199 A Novel prognostic scoring system to predict 3-month mortality risk in patients with acute-on-chronic liver failure in hepatitis B: a retrospective cohort study http://www.medworm.com/index.php?rid=5649453&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp475232255443357%2F Conclusions  We developed an objective, pertinent, and sensitive prognostic scoring system that predicted the 3-month mortality of patients with ACLFB with greater accuracy than the MELD. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s12072-011-9335-2Authors Yu-Bao Zheng, Department of Infectious Diseases, The Third Affiliated Hospital, Sun Yat-Sen University, Tianhe Road 600# Gangding, Guangzhou City, 510630 People’s Republic of ChinaShi-Bin Xie, Department of Infectious Diseases, The Third Affiliated Hospital, Sun Yat-Sen University, Tianhe Road 600# Gangding, Guangzhou City, 510630 People’s Republic of ChinaDong-Ying Xie, Department of Infectious Diseases, The Third Affiliated Hospital, Sun Yat-Sen University, Tianhe Road 600# Gangdi... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5649453 Sat, 28 Jan 2012 16:51:45 +0100 5649453 The 22nd Conference of the Asian Pacific Association for the Study of the Liver http://www.medworm.com/index.php?rid=5639175&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2m50581774558787%2F Content Type Journal ArticleCategory AbstractsPages 1-21DOI 10.1007/s12072-011-9330-7 Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 Journal Volume Volume 6 Journal Issue Volume 6, Number 1 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=5639175 Wed, 25 Jan 2012 18:14:41 +0100 5639175 Hypoxic hepatitis: a challenging diagnosis http://www.medworm.com/index.php?rid=5598896&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F378v6014l113r378%2F Abstract  Hypoxic hepatitis (HH), one of the most common causes of acute liver injury, has a prevalence of up to 10% of admissions in intensive care units across the world. Inadequate oxygen uptake by the hepatocytes resulting in centrilobular necrosis associated with abnormally raised levels of the serum transaminases (ALT, AST) in patients with clinical history of cardiac, respiratory, or circulatory failures is the key feature of this condition. Abstracts, reviews, case reports, and research letters from various sources such as Pubmed, Proquest, Ovid, Google Scholar, and ISI Web of Knowledge dating from 1970 to 2011 were read and analyzed thoroughly. A study of 100 patients with HH, carried out from 2009 to 2010 at Tongji Hospital of Tongji University, Shanghai, People... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5598896 Sat, 14 Jan 2012 16:41:44 +0100 5598896 The long way toward understanding host and viral determinants of therapeutic success in HCV infection http://www.medworm.com/index.php?rid=5598897&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fkq8356v113663602%2F Content Type Journal ArticleCategory EditorialPages 1-5DOI 10.1007/s12072-011-9339-yAuthors Pierre-Alain Rubbo, INSERM U1058, CHU Montpellier and Montpellier 1 University, Montpellier, FrancePhilippe Van de Perre, INSERM U1058, CHU Montpellier and Montpellier 1 University, Montpellier, FranceEdouard Tuaillon, INSERM U1058, CHU Montpellier and Montpellier 1 University, Montpellier, France Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=5598897 Fri, 13 Jan 2012 16:50:53 +0100 5598897 Ascites in patients with hepatocellular carcinoma: prevalence, associated factors, prognostic impact, and staging strategy http://www.medworm.com/index.php?rid=5583593&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4851gn5g7k020130%2F Conclusions  Ascites is often seen in HCC patients and is associated with both tumoral and cirrhosis factors and decreased long-term survival. The CLIP staging system is a more feasible prognostic model for HCC patients with ascites. The optimal treatment strategy for these patients remains to be investigated. Content Type Journal ArticleCategory Original ArticlePages 1-11DOI 10.1007/s12072-011-9338-zAuthors Chia-Yang Hsu, Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, 112 TaiwanYun-Hsuan Lee, Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, 112 TaiwanYi-Hsiang Huang, Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, 112 Taiwan... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5583593 Sat, 07 Jan 2012 16:52:02 +0100 5583593 Model systems and clinical applications of hepatic stem cells for liver regeneration http://www.medworm.com/index.php?rid=5538854&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F84h12501806676n5%2F Conclusions  With the accumulation of innovative and creative works, hepatic stem cells therapy will be a new approach for liver diseases. Content Type Journal ArticleCategory Review ArticlePages 1-12DOI 10.1007/s12072-011-9323-6Authors Min Zhang, Liver Diseases Center, The Second Xiangya Hospital, Changsha, 410011 ChinaYan Zhong, Liver Diseases Center, The Second Xiangya Hospital, Changsha, 410011 ChinaJun Chen, Liver Diseases Center, The Second Xiangya Hospital, Changsha, 410011 China Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=5538854 Tue, 20 Dec 2011 16:44:30 +0100 5538854 Low incidence and prevalence of primary biliary cirrhosis in Canterbury, New Zealand: a population-based study http://www.medworm.com/index.php?rid=5516103&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft953339313x75570%2F Conclusions  This is the first population-based epidemiological study of PBC conducted in New Zealand and only the second in the Southern Hemisphere. The incidence and prevalence are lower than the Northern Hemisphere, even though the majority of our population has shared genetic background with some of these countries. Our study has provided further support to the hypothesis that there may be a protective effect or lack of a risk factor for PBC in New Zealand. Content Type Journal ArticleCategory Original ArticlePages 1-5DOI 10.1007/s12072-011-9329-0Authors Jing Hieng Ngu, Department of Gastroenterology, Christchurch Hospital, Private bag 4710, Christchurch, Canterbury, New ZealandRichard Blair Gearry, Department of Gastroenterology, Christchurch Hospital, Private ... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5516103 Wed, 14 Dec 2011 16:43:15 +0100 5516103 Complete spectrum of AMA-M2 positive liver disease in north India http://www.medworm.com/index.php?rid=5495601&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd11q16t0114hq61q%2F Conclusion  This 13.5-year study demonstrates a definite rising annual incidence of AMA-M2-positive liver disease in north India. Complete evaluation of 50 patients indicated that a hepatitic variant of PBC (PBC-AIH), which is significantly associated with DRB1*03, predominates in north India. Content Type Journal ArticleCategory Original ArticlePages 1-6DOI 10.1007/s12072-011-9326-3Authors Ranjana W. Minz, Department of Immunopathology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012 IndiaNavchetan Kaur, Department of Immunopathology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012 IndiaShashi Anand, Department of Immunopathology, Post Graduate Institute of Medical Education and Research (... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5495601 Sat, 10 Dec 2011 16:55:58 +0100 5495601 Establishment and validation of a simple noninvasive model to predict significant liver fibrosis in patients with chronic hepatitis B http://www.medworm.com/index.php?rid=5495602&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr73274u373500107%2F Conclusions  AIAG, a simple marker panel consisting of conventional parameters, could easily predict significant fibrosis with a high degree of accuracy. Content Type Journal ArticleCategory Original ArticlePages 1-9DOI 10.1007/s12072-011-9328-1Authors Sheng-di Wu, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032 People’s Republic of ChinaYan-jun Ni, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032 People’s Republic of ChinaLi–li Liu, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032 People’s Republic of ChinaHai ... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5495602 Fri, 09 Dec 2011 17:08:15 +0100 5495602 IL28B, HCV core mutations, and hepatocellular carcinoma: does host genetic make-up shape viral evolution in response to immunity? http://www.medworm.com/index.php?rid=5488031&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff800746ql1210164%2F Abstract  Mutations in the core sequence of the HCV genome have been reported to influence treatment response, fibrosis progression, and hepatocarcinogenesis in Asian patients with genotype-1 chronic hepatitis C (CHC). In this issue, Miura et al. report data consistent with a causal relationship between the R70 → Q70 core variant and hepatocellular carcinoma (HCC) risk in CHC genotype-1b patients, by the prospective evaluation of changes in the consensus sequence in the entire open reading frame between treatment failure and HCC development or end of follow-up, and validation of the initial findings in a confirmatory cohort. Furthermore, they observed an association between the IL28B genotype, which is believed to influence the immune response to viral infection,... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5488031 Tue, 06 Dec 2011 17:04:23 +0100 5488031 Naturally occurring core immune-escape and carboxy-terminal mutations\truncations in patients with e antigen negative chronic hepatitis B http://www.medworm.com/index.php?rid=5477506&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw1356q67lq807173%2F Conclusion  Core immune-escape mutations cT12S, cS21T, cT67P, cE113D, and cP130T/Q are significantly higher in decompensated liver disease patients and could influence the severity of liver disease in HBeAg −ve CHB patients. Content Type Journal ArticleCategory Original ArticlePages 1-11DOI 10.1007/s12072-011-9316-5Authors Ranjit Chauhan, Department of Gastroenterology and Advanced Centre for Liver Diseases, G.B. Pant Hospital, Room No. 201, New Delhi, 110002 IndiaShiv K. Sarin, Department of Gastroenterology and Advanced Centre for Liver Diseases, G.B. Pant Hospital, Room No. 201, New Delhi, 110002 IndiaManoj Kumar, Department of Gastroenterology and Advanced Centre for Liver Diseases, G.B. Pant Hospital, Room No. 201, New Delhi, 110002 IndiaJayashree Bhattacharjee... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5477506 Thu, 01 Dec 2011 19:21:32 +0100 5477506 Transjugular intrahepatic portosystemic shunt in the treatment of portal vein thrombosis: a critical review of literature http://www.medworm.com/index.php?rid=5469919&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fnhw11335r3675434%2F In conclusion, the reviewed studies uniformly support the feasibility and safety of TIPS for PVT even in the presence of portal cavernoma. Further, several major issues that remain unresolved are discussed. Content Type Journal ArticleCategory Review ArticlePages 1-15DOI 10.1007/s12072-011-9324-5Authors Xingshun Qi, Fourth Military Medical University, Xijing Hospital of Digestive Diseases, 15 West Changle Road, Xi’an, 710032 ChinaGuohong Han, Fourth Military Medical University, Xijing Hospital of Digestive Diseases, 15 West Changle Road, Xi’an, 710032 China Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=5469919 Wed, 30 Nov 2011 18:52:15 +0100 5469919 Clinical features and prognosis of hepatocellular carcinoma in Mongolia: a multicentre study http://www.medworm.com/index.php?rid=5469921&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr218632k36848864%2F Conclusions  High proportion of patients with HCC in Mongolia is diagnosed at an advanced stage and survival of these patients is lower compared to other countries. A surveillance system and referral policy for high-risk groups should be urgently established and implemented in Mongolia. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s12072-011-9325-4Authors Oidov Baatarkhuu, Department of Internal Medicine, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-gu, 120-752 Seoul, South KoreaDo Young Kim, Department of Internal Medicine, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-gu, 120-752 Seoul, South KoreaPagbajabyn Nymadawa, Mongolian Academy of Medical Science, Ulaanbaatar, MongoliaSeung Up Kim, Departme... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5469921 Wed, 30 Nov 2011 04:38:32 +0100 5469921 Different aspects of CD4 T cells that lead to viral clearance or persistence of HCV infection http://www.medworm.com/index.php?rid=5469920&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F27w3651382x35p00%2F Abstract  More than 170 million people worldwide are infected with hepatitis C virus (HCV). A characteristic of this virus is a high tendency toward chronic infection. Several factors affect the viral outcome after infection. Among them, HCV-specific CD4 T cells are thought to play a crucial role in controlling viremia. Cumulative data showed that spontaneously resolved individuals have vigorous CD4 T-cell responses to a broad spectrum of HCV antigens and maintain these responses over a long period of time, whereas chronically infected patients lose their CD4 T-cell responses in the acute phase of infection. Although several possibilities of why CD4 T cells lose their function have been proposed, the mechanisms are not completely understood. Moreover, there is another subse... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5469920 Wed, 30 Nov 2011 04:38:32 +0100 5469920 Transarterial chemoembolization can prolong survival for patients with metastatic hepatocellular carcinoma: a propensity score matching analysis http://www.medworm.com/index.php?rid=5469922&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9756841202975329%2F Conclusions  TACE provides survival benefit for metastatic HCC patients. Prospective randomized controlled trials are warranted to delineate the role of combining TACE with sorafenib or other treatment for metastatic HCC. Content Type Journal ArticleCategory Original ArticlePages 1-10DOI 10.1007/s12072-011-9322-7Authors I-Cheng Lee, Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, 201 Shih-Pai Road, Sec. 2, Taipei, 112 TaiwanTeh-Ia Huo, Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, 201 Shih-Pai Road, Sec. 2, Taipei, 112 TaiwanYi-Hsiang Huang, Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, 201 Shih-Pai Road, Sec. 2, Taipei, 112 TaiwanYee Chao, Cance... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5469922 Wed, 30 Nov 2011 04:38:31 +0100 5469922 Hepatic angiogenesis and fibrosis are common features in morbidly obese patients http://www.medworm.com/index.php?rid=5459044&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F613143746675m5x7%2F Conclusion  In severely obese patients, fibrosis is probably promoted by mechanisms independent of NASH. In these patients, angiogenesis is activated early in the natural history of NAFLD and correlates with the severity of fibrosis. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s12072-011-9320-9Authors Monika Ciupińska-Kajor, Department of Pathomorphology, Medical University of Silesia, Katowice, PolandMarek Hartleb, Department of Gastroenterology and Hepatology, Medical University of Silesia, ul. Medyków 14, 40-752 Katowice, PolandMaciej Kajor, Department of Pathomorphology, Medical University of Silesia, Katowice, PolandMichał Kukla, Department of Pathophysiology, Medical University of Silesia, Zabrze, PolandMariusz Wyleżoł, Departm... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5459044 Mon, 28 Nov 2011 16:50:28 +0100 5459044 Efficacy of peginterferon α-2a and predictors of response in HBeAg-negative, genotype D-naive patients http://www.medworm.com/index.php?rid=5450127&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F144104v002118880%2F Conclusion  HBeAg-negative genotype D-naive patients treated with PEG-IFN α-2a achieved SVR in 23 (HBV <400 copies ml−1) and 57% (HBV <20,000 copies ml−1) of patients, a better response than previously reported that might be related to the absence of drug resistance in these naive patients. Pretreatment predictors of SVR were low body weight, high ALT, low HBV DNA, and low triglycerides. Content Type Journal ArticleCategory Original ArticlePages 1-9DOI 10.1007/s12072-011-9319-2Authors Hamad I. Al-Ashgar, Section of Gastroenterology, Department of Medicine (MBC-46), King Faisal Specialist Hospital and Research Center, P.O. Box 3354, Riyadh, 11211 Saudi ArabiaMohammed Q. Khan, Section of Gastroenterology, Department of Medicine (MBC-46), King Faisal... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5450127 Thu, 24 Nov 2011 17:43:40 +0100 5450127 Survival advantage of primary liver transplantation for hepatocellular carcinoma within the up-to-7 criteria with microvascular invasion http://www.medworm.com/index.php?rid=5349192&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fbq26742756143072%2F Conclusion  Primary LT for HCC with microvascular invasion and within the up-to-7 criteria doubled the chance of cure as compared with LR. Content Type Journal ArticleCategory Original ArticlePages 1-11DOI 10.1007/s12072-011-9318-3Authors See Ching Chan, State Key Laboratory for Liver Research, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, ChinaSheung Tat Fan, State Key Laboratory for Liver Research, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, ChinaKenneth S. H. Chok, Department of Surgery, The University of Hong Kong, Hong Kong, ChinaTan To Cheung, Department of Surgery, The University of Hong Kong, Hong Kong, ChinaAlbert C. Y. Chan, Department of Surgery, The University of Hong Kong, Hong Kong, ChinaJames Y. Y. Fung, Department of Medicin... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5349192 Fri, 21 Oct 2011 05:47:24 +0100 5349192 Risk of stroke following diagnosis with pyogenic liver abscess: a nationwide population-based study http://www.medworm.com/index.php?rid=5349193&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa79541m36100n858%2F Conclusions  We suggest a need for more intensive medical monitoring following PLA infection, especially during the first few months. However, data regarding smoking were unavailable in our dataset and may have biased our findings. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s12072-011-9317-4Authors Joseph J. Keller, School of Medical Laboratory Sciences and Biotechnology, Taipei Medical University, Taipei, TaiwanJiunn-Horng Kang, Department of Physical Medicine and Rehabilitation, Taipei Medical University Hospital, Taipei, TaiwanJau-Jiuan Sheu, Department of Neurology, Taipei Medical University Hospital, Taipei, TaiwanHerng-Ching Lin, School of Health Care Administration, College of Medicine, Taipei Medical University, 250 Wu-Hsing St, ... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5349193 Thu, 20 Oct 2011 15:47:52 +0100 5349193 Telbivudine in combination with adefovir versus adefovir monotherapy in HBeAg-positive, lamivudine-resistant chronic hepatitis B http://www.medworm.com/index.php?rid=5316485&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu22221225l0783r5%2F Conclusion  LDT + ADV combination treatment showed better outcomes against lamivudine resistant HBV than ADV alone, with a similar safety profile. Content Type Journal ArticleCategory Original ArticlePages 1-11DOI 10.1007/s12072-011-9314-7Authors Sang-Hoon Ahn, Department of Internal Medicine, Yonsei University College of Medicine, 250 Seongsanno, Seoul, South KoreaYoung-Oh Kweon, The Kyungpook National University Hospital, Daegu, KoreaSeung-Woon Paik, Department of Medicine/Gastroenterology, Samsung Medical Centre, Seoul, KoreaJoo-Hyun Sohn, Division of Gastroenterology, Hanyang University Guri Hospital, Gyeonggi-do, Suwon, KoreaKwan-Sik Lee, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, KoreaDong Joon Kim, Hallym University Sacr... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5316485 Wed, 12 Oct 2011 05:50:26 +0100 5316485 Predictive factors for platelet count after laparoscopic splenectomy in cirrhotic patients http://www.medworm.com/index.php?rid=5286849&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fpn4r118802883753%2F Conclusions  Platelet count after splenectomy in cirrhotic patients can be predicted on the basis of preoperative clinical characteristics. When selecting patients for splenectomy, spleen weight, preoperative platelet count, and lymphocyte count should be taken into consideration. Content Type Journal ArticleCategory Original ArticlePages 1-5DOI 10.1007/s12072-011-9315-6Authors Daisuke Yoshida, Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanYoshihiro Nagao, Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanMorimasa Tomikawa, Department of Advanced Medicine and Innovative Technology, Kyushu University Hospital, Fukuoka, JapanHirofumi Kawanaka, Department of... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5286849 Fri, 30 Sep 2011 06:21:33 +0100 5286849 Morphological and biomechanical remodelling of the hepatic artery in a swine model of portal hypertension http://www.medworm.com/index.php?rid=5251641&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx26j22xk10718831%2F Conclusions  The study suggests that the morphological and biomechanical properties of swine hepatic arteries have changed significantly during the process of portal hypertension and that from biomechanical aspects, the hepatic arteries have also suffered from extensive remodelling, which in turn deteriorates the existing portal hypertension. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s12072-011-9302-yAuthors Xi-Ju He, Institute of Basic Medical Sciences, Hubei University of Medicine, Shiyan, ChinaMing-Hua Yu, Institute of Basic Medical Sciences, Hubei University of Medicine, Shiyan, ChinaWen-Chun Li, Institute of Basic Medical Sciences, Hubei University of Medicine, Shiyan, ChinaHan-Qin Wang, Institute of Basic Medical Sciences, Hubei ... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5251641 Fri, 23 Sep 2011 05:44:11 +0100 5251641 Characteristics of autoimmune hepatitis in the Asia-Pacific Region: historical review http://www.medworm.com/index.php?rid=5239201&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj0xp228026283408%2F Conclusion  In the era of genome-wide association studies, further progress of studies on AIH, a typical disease model for immunological liver cell damage, is expected. Content Type Journal ArticleCategory Review ArticlePages 1-8DOI 10.1007/s12072-011-9313-8Authors Mikio Zeniya, The Jikei University Graduate School of Medicine Gastroenterology, Tokyo, JapanHiroki Takahashi, The Jikei University Graduate School of Medicine Gastroenterology, Tokyo, Japan Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=5239201 Sat, 17 Sep 2011 17:06:46 +0100 5239201 Disadvantages of peginterferon and ribavirin treatment in older patients with chronic hepatitis C: an analysis using the propensity score http://www.medworm.com/index.php?rid=5210293&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl584071002064666%2F Conclusions  The analysis using PS indicated that RBV adherence in the older patients decreased even if they did not have lower pretreatment RBC and Hgb levels. Content Type Journal ArticleCategory Original ArticlePages 1-9DOI 10.1007/s12072-011-9312-9Authors Hirotoshi Ebinuma, Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582 JapanHidetsugu Saito, Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582 JapanShinichiro Tada, Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, S... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5210293 Fri, 09 Sep 2011 16:46:47 +0100 5210293 Noncirrhotic portal fibrosis: a rare cause of end-stage liver disease requiring liver transplantation http://www.medworm.com/index.php?rid=5197106&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx388702703l538rn%2F Content Type Journal ArticleCategory EditorialPages 1-3DOI 10.1007/s12072-011-9311-xAuthors Sunil Taneja, Department of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012 IndiaYogesh Chawla, Department of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012 IndiaRadha K. Dhiman, Department of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012 India Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=5197106 Sat, 03 Sep 2011 06:39:47 +0100 5197106 Characteristics of hepatocellular carcinoma nodules newly detected by computed tomography during arteriography and arterial portography: preliminary report of a randomized controlled trial http://www.medworm.com/index.php?rid=5185058&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fmv82724727775167%2F Conclusion  CTHA/CTAP may be useful for detecting additional nodules prior to percutaneous ablation in patients with multinodular HCC on dynamic CT, in recurrent cases, and in hepatitis B surface antigen-negative cases. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s12072-011-9310-yAuthors Takamasa Ohki, Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 JapanRyosuke Tateishi, Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 JapanMasaaki Akahane, Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanShuichiro Shiina, Department of Gastroenterology, Gradua... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5185058 Tue, 30 Aug 2011 15:59:32 +0100 5185058 Comparison between acetylator phenotype and genotype polymorphism of n-acetyltransferase-2 in tuberculosis patients http://www.medworm.com/index.php?rid=5163710&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F56181wt236780127%2F Conclusion  This study suggests that the acetylator status of TB patients can be detected by phenotypic method as efficaciously as by genotypic method. Therefore, phenotypic method can replace genotypic method to determine acetylating status as phenotypic method is simple and inexpensive. Content Type Journal ArticleCategory Original ArticlePages 1-6DOI 10.1007/s12072-011-9309-4Authors S. V. Rana, Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, IndiaR. P. Ola, Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, IndiaSanjeev K. Sharma, Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, IndiaS. K. Arora, Department o... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5163710 Wed, 24 Aug 2011 16:03:20 +0100 5163710 Hepatitis C virus (genotype 4)-associated mixed cryoglobulinemia vasculitis: effects of antiviral treatment http://www.medworm.com/index.php?rid=5163711&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg11537614401g534%2F Conclusion  The results indicated that treatment with PEG-IFN alfa-2a plus ribavirin can achieve a complete clinical response in patients with HCV-related MC. Complete clinical response correlates with the eradication of HCV. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s12072-011-9303-xAuthors Hisham R. El Khayat, Department of Gastroenterology, Theodore Bilharz Institute, Cairo, EgyptYasser M. Fouad, Department of Tropical Medicine, Minia University, Minia, EgyptEzzat Ali Ahmad, Department of Internal Medicine, Alexandria University, Alexandria, EgyptHussein El Amin, Department of Internal Medicine, Assiut University, Assiut, EgyptFaten Ismael, Department Rheumatology, Minia University, Minia, EgyptAmal Rizk, Department Rheumatology, Cai... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5163711 Fri, 19 Aug 2011 06:40:07 +0100 5163711 Thyroid autoantibodies and dysfunction do not impact the treatment efficacy of peginterferon and ribavirin combination therapy in chronic hepatitis C http://www.medworm.com/index.php?rid=5163712&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F425v38376544377p%2F Conclusion  Taiwanese CHC patients with rs8099917 TT genotype had a higher incidence of TAs. The development of TAs and TD did not impact the treatment efficacy of PegIFN/RBV combination therapy. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s12072-011-9308-5Authors Jee-Fu Huang, Department of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanChao-Kuan Huang, Department of Occupational and Environmental Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanMing-Lung Yu, Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanChia-Yen Dai, Hepatobiliary Division, Department of Internal ... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5163712 Thu, 18 Aug 2011 05:47:59 +0100 5163712 Characterization of naturally occurring protease inhibitor-resistance mutations in genotype 1b hepatitis C virus patients http://www.medworm.com/index.php?rid=5163713&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft2j04514578q4h01%2F Conclusions  PI-resistance-associated NS3 mutations exist in a substantial proportion of untreated HCV-1b-infected patients. The impact of these mutations in the treatment of PIs is unclear, but clinicians should pay attention to avoid further development of PI resistance. Content Type Journal ArticleCategory Original ArticlePages 1-9DOI 10.1007/s12072-011-9306-7Authors Hiroko Shindo, First Department of Internal Medicine, University of Yamanashi, 1110, Shimokato, Chuo, Yamanashi 409-3898, JapanShinya Maekawa, First Department of Internal Medicine, University of Yamanashi, 1110, Shimokato, Chuo, Yamanashi 409-3898, JapanKazuki Komase, First Department of Internal Medicine, University of Yamanashi, 1110, Shimokato, Chuo, Yamanashi 409-3898, JapanRyota Sueki, First Dep... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5163713 Thu, 18 Aug 2011 05:47:58 +0100 5163713 Analysis of viral amino acids sequences and the IL28B SNP influencing the development of hepatocellular carcinoma in chronic hepatitis C http://www.medworm.com/index.php?rid=5163714&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff87630ll50455567%2F Conclusions  Hepatitis C virus core a.a. 70 residue is associated with liver disease progression and is independent factor for HCC development in genotype-1b infection. IL28B SNPs are related to core a.a. 70 residue, but not to HCC. The functional relevance of core a.a. 70 residue in hepatitis C pathogenesis should be further investigated. Content Type Journal ArticleCategory Original ArticlePages 1-11DOI 10.1007/s12072-011-9307-6Authors Mika Miura, First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, 1110, Shimokato, Chuo, Yamanashi, 409-3898 JapanShinya Maekawa, First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, 1110, Shimokato, Chuo, Yamanashi, 409-3898 JapanMakoto Kadokura, First Department of Inte... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5163714 Wed, 17 Aug 2011 05:56:03 +0100 5163714 Non-alcoholic fatty liver disease: is iron relevant? http://www.medworm.com/index.php?rid=5133047&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu0217uj974j62771%2F Abstract  Non-alcoholic fatty liver disease (NAFLD) is a common and ubiquitous disorder (Bedogni et al. in Hepatology 42:44–52, 2005; Bellentani et al. in Ann Intern Med 132:112–117, 2000) which in a proportion of subjects leads to non-alcoholic steatohepatitis (NASH), advanced liver disease and hepatocellular carcinoma. Although the factors responsible for progression of disease are still uncertain, there is evidence that insulin resistance (IR) is a key operative mechanism (Angulo et al. in Hepatology 30:1356–1362, 1999) and that two stages are involved. The first is the accumulation of triglycerides in hepatocytes followed by a “second hit” which promotes cellular oxidative stress. Several factors may be responsible for the induction of oxidative stress but hep... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5133047 Fri, 12 Aug 2011 06:18:34 +0100 5133047 Prevention of post liver transplant HBV recurrence http://www.medworm.com/index.php?rid=5120648&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg38w375828j06607%2F Conclusion   Thus, 20 years afterward, HBV recurrence is <5% and outcomes following liver transplantation are excellent. Content Type Journal ArticlePages 1-6DOI 10.1007/s12072-011-9293-8Authors Geoffrey W. McCaughan, The AW Morrow Gastroenterology and Liver Centre, The Centenary Research Institute, Royal Prince Alfred Hospital and The University of Sydney, Missenden Road, Camperdown, NSW 2050, Australia Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=5120648 Wed, 10 Aug 2011 15:48:57 +0100 5120648 Effects of mutation number in interferon sensitivity determining region on peripheral blood CD4+ T cell subsets (Th1, Th2) in chronic hepatitis C patients with hepatitis C virus genotype 1b and high viral load http://www.medworm.com/index.php?rid=5110695&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv4019684312x5871%2F Conclusion  The number of AA mutations in the ISDR influenced PB Th2 cells before and until day 28, and was associated with higher RVR and EVR rates. Content Type Journal ArticlePages 1-7DOI 10.1007/s12072-011-9305-8Authors Koji Ishii, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Faculty of Medicine, Toho University School of Medicine, 6-11-1, Omorinishi, Otaku, Tokyo, 143-8541 JapanMie Shinohara, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Faculty of Medicine, Toho University School of Medicine, 6-11-1, Omorinishi, Otaku, Tokyo, 143-8541 JapanMichio Kogame, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Faculty of Medicine, Toho University School of Medicine, 6-11-1, Omo... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5110695 Fri, 05 Aug 2011 06:02:34 +0100 5110695 Hepatocyte growth factor overexpression ameliorates liver inflammation and fibrosis in a mouse model of nonalcoholic steatohepatitis http://www.medworm.com/index.php?rid=5110694&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F52t343u145126842%2F Conclusion  Hepatocyte growth factor ameliorated liver inflammation and fibrosis in a murine model of NASH as a result of the anti-oxidative and anti-apoptotic effect, and the induction of fibrinolysis. Content Type Journal ArticlePages 1-11DOI 10.1007/s12072-011-9301-zAuthors Hiroki Tojima, Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, JapanSatoru Kakizaki, Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, JapanTakashi Kosone, Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, JapanNorio Horiguchi, Department of Medicine and Molecular Science, Gunma University Gra... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5110694 Fri, 05 Aug 2011 06:02:34 +0100 5110694 Hepatitis C virus and lipid profiles: more questions than answers? http://www.medworm.com/index.php?rid=5089227&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9112117r787l1136%2F Content Type Journal ArticlePages 1-3DOI 10.1007/s12072-011-9298-3Authors Ching-Sheng Hsu, Division of Gastroenterology, Department of Internal Medicine, Buddhist Tzu Chi General Hospital, Taipei, TaiwanJia-Horng Kao, Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei, 10002 Taiwan Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=5089227 Thu, 28 Jul 2011 15:56:38 +0100 5089227 Human-induced pluripotent stem cells as a source of hepatocyte-like cells: new kids on the block http://www.medworm.com/index.php?rid=5064429&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2823478082785434%2F Content Type Journal ArticlePages 1-7DOI 10.1007/s12072-011-9300-0Authors C. Busletta, Department of Experimental Medicine and Oncology, InterUniversity Center for Hepatic Pathophysiology, University of Torino, Corso Raffaello 30, 10125 Turin, ItalyE. Novo, Department of Experimental Medicine and Oncology, InterUniversity Center for Hepatic Pathophysiology, University of Torino, Corso Raffaello 30, 10125 Turin, ItalyM. Parola, Department of Experimental Medicine and Oncology, InterUniversity Center for Hepatic Pathophysiology, University of Torino, Corso Raffaello 30, 10125 Turin, Italy Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=5064429 Fri, 22 Jul 2011 17:04:49 +0100 5064429 Host genetic variants and hepatitis B virologic features in HBeAg-negative hepatitis B carriers with long-term biochemical remission http://www.medworm.com/index.php?rid=5064430&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F577j4220830u08pw%2F Conclusions  The results indicate that lower baseline serum HBV-DNA level and viral load reduction over time are associated with long-term biochemical remission in HBeAg-negative hepatitis B carriers. Content Type Journal ArticlePages 1-8DOI 10.1007/s12072-011-9297-4Authors Chih-Lin Lin, Department of Gastroenterology, Taipei City Hospital, Ren-Ai branch, Taipei, TaiwanTai-Chung Tseng, Division of Hepatogastroenterology, Department of Internal Medicine, Buddhist Tzu Chi General Hospital, Taipei Branch, Taipei, TaiwanTung-Hung Su, Department of Internal Medicine, National Taiwan University Hospital, Taipei, TaiwanChun-Jen Liu, Department of Internal Medicine, National Taiwan University Hospital, Taipei, TaiwanPei-Jer Chen, Department of Internal Medicine, National Taiw... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5064430 Thu, 21 Jul 2011 18:08:58 +0100 5064430 A randomized, multi-central, controlled study of patients with hepatitis B e antigen-positive chronic hepatitis B treated by adefovir dipivoxil or adefovir dipivoxil plus bicyclol http://www.medworm.com/index.php?rid=5064431&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2037228772310281%2F Conclusion  Adefovir dipivoxil plus bicyclol combination therapy is a safe and superior treatment regimen for patients with HBeAg-positive CHB when compared with ADV monotherapy. Content Type Journal ArticlePages 1-8DOI 10.1007/s12072-011-9294-7Authors Wen Xie, Liver Center, Beijing Ditan Hospital, Capital Medical University, 100015 Beijing, ChinaGuangfeng Shi, Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, ChinaHongfei Zhang, Department of Pediatric Hepatology, The 302 Hospital of PLA, Beijing, ChinaGuiming Zhao, Department of Hepatology, Tianjin Municipal Hospital of Infectious Diseases, Tianjin, ChinaZujiang Yu, Department of Infectious Diseases, First Hospital, Zhengzhou University, Zhengzhou, ChinaZhenwei Lang, Liver Center, Beij... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5064431 Tue, 19 Jul 2011 23:22:58 +0100 5064431 Serum interleukin 6 level correlates with outcomes of acute exacerbation of chronic hepatitis B http://www.medworm.com/index.php?rid=5064432&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4g48112287qg2637%2F Conclusions  Our findings indicate that undetectable serum IL-6 level at the early stage of AE correlated with the long-term outcomes and may serve as a useful clinical predictor. Content Type Journal ArticlePages 1-7DOI 10.1007/s12072-011-9299-2Authors Corinna Jen-Hui Pan, Melbourne University, Melbourne, AustraliaHui-Lin Wu, Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, 1 Chang-Te Street, Taipei, 10002 TaiwanStephanie Fang-Tzu Kuo, Melbourne University, Melbourne, AustraliaJia-Horng Kao, Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, 1 Chang-Te Street, Taipei, 10002 TaiwanTai-Chung Tseng, Graduate Instit... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5064432 Tue, 19 Jul 2011 05:47:37 +0100 5064432 Current management and recommendations on hepatitis B therapy in HIV-coinfected patients http://www.medworm.com/index.php?rid=5041009&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd00203535581243v%2F Conclusion  Even though global management of HBV–HIV coinfected patients is improving, baseline evaluation of CHB though necessary is still often insufficient. The strong rationale for early dual anti-HIV and anti-HBV therapy, and the reality of everyday clinical practice, bring support to the recent simplification of the recommendations widening the use of tenofovir and emtricitabine in HBV–HIV coinfected patients, irrespective of immunological, virological, or histological considerations. Content Type Journal ArticlePages 1-6DOI 10.1007/s12072-011-9292-9Authors Lionel Piroth, Département d’ Infectiologie, CHU Dijon and Université de Bourgogne, 10 boulevard du Maréchal de Lattre de Tassigny, 21079 Dijon Cedex, FranceSophie Mahy, Département d’ Infectiol... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5041009 Thu, 14 Jul 2011 16:55:46 +0100 5041009 Comparison of noninvasive models of fibrosis in chronic hepatitis B http://www.medworm.com/index.php?rid=5031424&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fcn7716620nu15100%2F Conclusions  Serum fibrosis models are predictive of fibrosis in CHB and assist in identifying subjects with low–normal ALT levels for treatment. Content Type Journal ArticlePages 1-11DOI 10.1007/s12072-011-9296-5Authors S. C. Raftopoulos, Department of Gastroenterology, Sir Charles Gairdner Hospital, Perth, AustraliaJ. George, Storr Liver Unit, Westmead Millenium Institute, Westmead Hospital, University of Sydney, Sydney, AustraliaM. Bourliere, Service d’Hépato-Gastroentérologie, Hôpital Saint Joseph, Marseille, FranceE. Rossi, Department of Clinical Microbiology, PathWest Laboratory Medicine, Perth, AustraliaW. B. de Boer, Department of Clinical Microbiology, PathWest Laboratory Medicine, Perth, AustraliaG. P. Jeffrey, Department of Gastroenterology, Sir Char... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5031424 Tue, 12 Jul 2011 06:05:11 +0100 5031424 The therapeutic response of antiviral therapy in HBsAg-positive renal transplant recipients and a long-term follow-up http://www.medworm.com/index.php?rid=5031425&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd016687158142335%2F Conclusions  The rate of LAM resistance in RTRs is similar to immunocompetent CHB patients in a 2-year therapy. By roadmap concept, RTRs with IAVR require a change in therapy to prevent viral resistance. Relapse after LAM withdrawal is frequent. Long-term antiviral therapy is crucial for immunosuppressed patients. Content Type Journal ArticlePages 1-8DOI 10.1007/s12072-011-9295-6Authors Tsung-Hui Hu, Division of Hepato-Gastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta Pei Road, Niao Sung District, Kaohsiung, 833 TaiwanMing-Chao Tsai, Division of Hepato-Gastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College ... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5031425 Mon, 11 Jul 2011 05:35:08 +0100 5031425 Serum apolipoprotein C-III is independently associated with chronic hepatitis C infection and advanced fibrosis http://www.medworm.com/index.php?rid=5021857&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq64134510433v424%2F Conclusions  Relative to other lipoproteins, low serum Apo C-III levels are the most strongly associated with chronic versus cleared infection and decline with increasing severity of hepatic fibrosis. Apo C-III deserves further attention as a possible marker of HCV disease progression. Content Type Journal ArticlePages 1-7DOI 10.1007/s12072-011-9291-xAuthors J. Rowell, Division of Endocrinology, Department of Medicine, Metabolism and Nutrition, Duke University, Durham, NC, USAA. J. Thompson, Department of GI/Hepatology Research Program, Duke Clinical Research Institute, Duke University, PO Box 17969, Durham, NC 27715, USAJ. R. Guyton, Division of Endocrinology, Department of Medicine, Metabolism and Nutrition, Duke University, Durham, NC, USAX. Q. Lao, Institute for ... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5021857 Thu, 07 Jul 2011 05:46:03 +0100 5021857 Impact of hepatic clearance of endotoxin using endotoxin activity assay http://www.medworm.com/index.php?rid=5010663&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9736473471077w20%2F Conclusions  The EAA is considered to be superior to the LAL method for the detection of Et, even in low endotoxinemia, and is also capable of elucidating the Et kinetics by accurately reflecting hepatic clearance. Content Type Journal ArticlePages 1-5DOI 10.1007/s12072-011-9289-4Authors Yukihiro Sanada, Department of Transplant Surgery, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke City, Tochigi 329-0498, JapanKoichi Mizuta, Department of Transplant Surgery, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke City, Tochigi 329-0498, JapanTaizen Urahashi, Department of Transplant Surgery, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke City, Tochigi 329-0498, JapanYoshiyuki Ihara, Department of Transplant Surgery, Jichi Medical University, 3311-1 Ya... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5010663 Wed, 06 Jul 2011 06:34:47 +0100 5010663 Recurrence rates and factors for recurrence after radiofrequency ablation combined with transarterial chemoembolization for hepatocellular carcinoma: a retrospective cohort study http://www.medworm.com/index.php?rid=5010664&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh86m430kj5q74676%2F Conclusions  The recurrence rate of combination therapy was considerably high. Regardless of the therapy used, careful post-RFA follow-up is needed, especially if additional treatment is required after the first session or if the main lesion is ≥2 cm at the time of RFA. Content Type Journal ArticlePages 1-6DOI 10.1007/s12072-011-9290-yAuthors Jeong Han Kim, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Gojan-dong, Danwon-gu, Ansan-si, Gyeonggi-do, 425-707 KoreaHyung Joon Yim, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Gojan-dong, Danwon-gu, Ansan-si, Gyeo... Hepatology International journals http://www.medworm.com/rss/comments.php?id=5010664 Mon, 04 Jul 2011 16:17:27 +0100 5010664 The effect of changes of model for end-stage liver disease score during waiting time on post-liver transplant mortality http://www.medworm.com/index.php?rid=4987071&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa647947428qu4tt4%2F Conclusion  In a country with a single transplant center and organ retrieval organization, the addition of MELD score to current minimal listing criteria does not improve prioritization of patients on the waiting list or predict posttransplant survival. Also, adjusting MELD score for HCC would unfairly disadvantage patients listed without HCC. Content Type Journal ArticlePages 1-7DOI 10.1007/s12072-011-9287-6Authors Mohammad A. B. Al-Freah, The New Zealand Liver Transpalnt Unit, Auckland City Hospital, Private Bag 92024, Auckland 1142, Auckland, New ZealandEdward J. Gane, The New Zealand Liver Transpalnt Unit, Auckland City Hospital, Private Bag 92024, Auckland 1142, Auckland, New ZealandVicki Livingstone, Department of Community Medicine, University of Otago, Dunedi... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4987071 Wed, 29 Jun 2011 15:50:48 +0100 4987071 Delayed periportal enhancement: a characteristic finding on contrast ultrasound in idiopathic portal hypertension http://www.medworm.com/index.php?rid=4987072&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn196x14u64g14838%2F Conclusions  Delayed periportal enhancement on the sonograms based on perflubutane microbubble agent may be a characteristic of IPH. Content Type Journal ArticlePages 1-9DOI 10.1007/s12072-011-9285-8Authors Hitoshi Maruyama, Department of Medicine and Clinical Oncology, Chiba University Graduate School of Medicine, 1-8-1, Inohana, Chuou-ku, Chiba, 260-8670 JapanTaro Shimada, Department of Medicine and Clinical Oncology, Chiba University Graduate School of Medicine, 1-8-1, Inohana, Chuou-ku, Chiba, 260-8670 JapanHiroyuki Ishibashi, Department of Medicine and Clinical Oncology, Chiba University Graduate School of Medicine, 1-8-1, Inohana, Chuou-ku, Chiba, 260-8670 JapanMasanori Takahashi, Department of Medicine and Clinical Oncology, Chiba University Graduate School of Med... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4987072 Tue, 28 Jun 2011 06:05:05 +0100 4987072 Murine gamma herpes virus 68 infection promotes fatty liver formation and hepatic insulin resistance in C57BL/6J mice http://www.medworm.com/index.php?rid=4971230&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv430613744021l4p%2F Conclusion  In C57BL/6J mice, MHV68 infection promotes fatty liver formation and hepatic insulin resistance, which can be ameliorated by sirolimus. Content Type Journal ArticlePages 1-11DOI 10.1007/s12072-011-9283-xAuthors Lei Zhao, Centre for Lipid Research, Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Second Affiliated Hospital, Chongqing Medical University, Chongqing, People’s Republic of ChinaYa-Xi Chen, Centre for Lipid Research, Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Second Affiliated Hospital, Chongqing Medical University, Chongqing, People’s Republic of ChinaZac Varghese, Lipid Research Unit, Centre for Nephrology, University College London (UCL) Medical School, Royal Free Ca... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4971230 Thu, 23 Jun 2011 16:13:11 +0100 4971230 Hepatitis B surface antigen: association with sustained response to peginterferon alfa-2a in hepatitis B e antigen-positive patients http://www.medworm.com/index.php?rid=4971231&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl16t03284048q856%2F Conclusions  HBsAg levels at baseline strongly associated with posttreatment response were not identified. Low HBsAg levels during peginterferon alfa-2a therapy were associated with high rates of posttreatment response. On-treatment HBsAg quantification may, therefore, help guide patient management in the future. Content Type Journal ArticlePages 1-8DOI 10.1007/s12072-011-9280-0Authors Teerha Piratvisuth, NKC Institute of Gastroenterology and Hepatology, Songklanagarind Hospital, Prince of Songkla University, Hat Yai, ThailandPatrick Marcellin, Service d’Hépatologie U773-CRB3, Hôpital Beaujon, University of Paris, Clichy, FranceMatei Popescu, F.Hoffmann-La Roche, Basel, SwitzerlandHans-Peter Kapprell, Abbott GmbH and Company, Wiesbaden-Delkenheim, GermanyVivien R... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4971231 Thu, 23 Jun 2011 16:13:10 +0100 4971231 Higher prevalence of chronic kidney disease and shorter renal survival in patients with chronic hepatitis C virus infection http://www.medworm.com/index.php?rid=4971232&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr530560567k86181%2F Conclusion  Chronic HCV infection was associated with a significantly higher prevalence of CKD compared with controls, as well as significantly shorter renal survival. A higher baseline viral load is an independent predictor of CKD. Content Type Journal ArticlePages 1-10DOI 10.1007/s12072-011-9284-9Authors Sanjaya Kumar Satapathy, Department of Internal Medicine, New York Medical College/Metropolitan Hospital Center, New York, 10029 USAChandra Sekhar Lingisetty, Department of Internal Medicine, New York Medical College/Metropolitan Hospital Center, New York, 10029 USASusan Williams, Department of Gastroenterology, New York Medical College/Metropolitan Hospital Center, 1901 First Avenue, New York, 10029 USA Journal Hepatology InternationalOnline ISSN 1936-0541Pr... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4971232 Thu, 23 Jun 2011 06:12:38 +0100 4971232 The use of transient elastography in the management of chronic hepatitis B http://www.medworm.com/index.php?rid=4971233&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft2570g7451642670%2F Abstract  There has been increasing interest in noninvasive methods of assessing liver fibrosis over the last decade. The use of transient elastography in measuring liver stiffness has become the forefront of a wide range of noninvasive tools. Most of the other methods are based on measurements of biomarkers associated with fibrosis. There are several reasons for its wide acceptance, including the ease of performing a scan, the short procedure time, the results being immediately available on completion of the examination, and its reproducibility. For chronic hepatitis B (CHB), the cut-off values for F3 and F4 fibrosis range between 7.5–12.0 and 11.0–13.4 kPa, respectively, although the cut-offs may be slightly lower in those with normal ALT. In addition to measurin... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4971233 Wed, 22 Jun 2011 06:09:16 +0100 4971233 Tenofovir disoproxil fumarate for the treatment of chronic hepatitis B monoinfection http://www.medworm.com/index.php?rid=4971234&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fwt3503365225k50j%2F Conclusions   TDF has the makings of an “ideal” first-line drug for the treatment of CHB. Content Type Journal ArticlePages 1-8DOI 10.1007/s12072-011-9282-yAuthors Wai-Kay Seto, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, Hong KongMan-Fung Yuen, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, Hong KongJames Fung, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, Hong KongChing-Lung Lai, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, Hong Kong Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=4971234 Tue, 21 Jun 2011 18:01:05 +0100 4971234 Protective effects of green tea against hepatic injury induced by high-cholesterol diet in rats: histopathological analysis, oxidative DNA damage and COX-2 expression http://www.medworm.com/index.php?rid=4971235&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F280p534327727171%2F Conclusion  Taken together, our results suggest that daily administration of green tea for at least 7 days displays some preventive properties as indicated by COX-2 downregulation and decreased oxidative DNA damage. Content Type Journal ArticlePages 1-10DOI 10.1007/s12072-011-9275-xAuthors Bárbara B. de Moraes, Departamento de Biociências, Universidade Federal de São Paulo, UNIFESP, Santos, SP, BrazilGabriela Pasquini, Departamento de Biociências, Universidade Federal de São Paulo, UNIFESP, Santos, SP, BrazilOdair Aguiar, Departamento de Biociências, Universidade Federal de São Paulo, UNIFESP, Santos, SP, BrazilAndréa P. B. Gollücke, HEXALAB and Nutrition Department, Catholic University of Santos, Santos, BrazilSilvia S. M. Ihara, Departamento de Patolog... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4971235 Tue, 21 Jun 2011 16:41:41 +0100 4971235 Age is not a contraindication for orthotopic liver transplantation: a single institution experience with recipients older than 75 years http://www.medworm.com/index.php?rid=4962169&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg482j2t36v022540%2F Conclusion   Our study demonstrates that a with proper evaluation and careful consideration of risk factors, individuals older than 75 years of age can undergo this life-saving procedure with acceptable long-term survival. Content Type Journal ArticlePages 1-5DOI 10.1007/s12072-011-9286-7Authors C. Burcin Taner, Department of Transplantation, Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL 32224, USARyan L. Ung, Department of Transplantation, Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL 32224, USABarry G. Rosser, Department of Transplantation, Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL 32224, USAJaime Aranda-Michel, Department of Transplantation, Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL 32224, USA ... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4962169 Sat, 18 Jun 2011 05:42:00 +0100 4962169 Intraoperative injuries during liver resection: analysis of 1,005 procedures http://www.medworm.com/index.php?rid=4947095&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fnn7np335362l8p3t%2F Conclusions  Minor injuries causing no significant complications were the most frequent. However, prevention and proper management of the rare injuries of hepatocaval junction are essential to avoid increased mortality in major liver resections. Content Type Journal ArticlePages 1-7DOI 10.1007/s12072-011-9281-zAuthors Michal Grat, Department of General, Transplant and Liver Surgery, Medical University of Warsaw, 1A Banacha Street, 02-097 Warsaw, PolandKarolina Grzegorczyk, Department of General, Transplant and Liver Surgery, Medical University of Warsaw, 1A Banacha Street, 02-097 Warsaw, PolandZbigniew Lewandowski, Department of Epidemiology, Medical University of Warsaw, Oczki Street, 02-007 Warsaw, PolandDamian Sujecki, Department of General, Transplant and Liver Su... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4947095 Tue, 14 Jun 2011 05:54:52 +0100 4947095 Hepatitis B virus reactivation in patients receiving cancer chemotherapy: natural history, pathogenesis, and management http://www.medworm.com/index.php?rid=4947096&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe486310264726454%2F Abstract  Chronic hepatitis B virus (HBV) infection is endemic in the Asian-Pacific region, and reactivation of HBV post-cancer chemotherapy has become an emerging clinical challenge. Patients with detectable serum HBV DNA before chemotherapy and those receiving intensive chemotherapy are particularly at a risk of HBV reactivation. Most patients with HBV reactivation are positive for hepatitis B surface antigen (HBsAg) and are, therefore, easily identified by recommended serological screening before chemotherapy. However, a small, but significant proportion of subjects who have apparently recovered from HBV infection as reflected by HBsAg negativity and hepatitis B core antibody positivity in HBV endemic areas may also experience reactivation when host immunity is severely ... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4947096 Tue, 14 Jun 2011 05:54:51 +0100 4947096 Clinical significance of serum autoantibodies in patients with NAFLD: results from the nonalcoholic steatohepatitis clinical research network http://www.medworm.com/index.php?rid=4814769&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq601263198343vh7%2F Conclusion  Autoantibodies are frequently positive in NAFLD in the absence of autoimmune hepatitis and their occurrence is not associated with more advanced histologic features. Content Type Journal ArticlePages 1-7DOI 10.1007/s12072-011-9277-8Authors Raj Vuppalanchi, Indiana University School of Medicine, Indianapolis, IN, USARobert J. Gould, Centre for Liver Disease, Virginia Mason Medical Centre, Seattle, WA, USALaura A. Wilson, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USAAynur Unalp-Arida, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USAOscar W. Cummings, Indiana University School of Medicine, Indianapolis, IN, USANaga Chalasani, Indiana University School of Medicine,... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4814769 Tue, 10 May 2011 05:56:15 +0100 4814769 Efficacy of combined pegylated interferon and ribavirin therapy in Jewish patients of Israel suffering from chronic hepatitis C http://www.medworm.com/index.php?rid=4806953&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6707836t86040712%2F Conclusions  Combined pegylated interferon and ribavirin therapy was of similar or even higher efficacy in the Israeli population as compared to that reported by international trials in Caucasian, Hispanic, and African American populations. Content Type Journal ArticlePages 1-6DOI 10.1007/s12072-011-9278-7Authors Jorge-Shmuel Delgado, Department of Gastroenterology and Hepatology, Faculty of Health Sciences, The Barzilai Medical Centre, Ben-Gurion University of the Negev, Beersheba, IsraelYael Baumfeld, Faculty of Health Sciences, Clinical Research Centre, Soroka University Medical Centre, Ben-Gurion University of the Negev, Beersheba, IsraelVictor Novack, Faculty of Health Sciences, Clinical Research Centre, Soroka University Medical Centre, Ben-Gurion University of ... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4806953 Sat, 07 May 2011 15:45:32 +0100 4806953 Early identification of poor responders to transarterial chemoembolization for hepatocellular carcinoma http://www.medworm.com/index.php?rid=4783492&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F845624t0hk7k6412%2F Conclusions  Poor responders have an increased risk of mortality due to rapid disease progression after TACE. Advanced BCLC stages may better predict a poor response to TACE. Content Type Journal ArticlePages 1-10DOI 10.1007/s12072-011-9276-9Authors Ya-Ju Tsai, School of Nursing, National Yang-Ming University, Taipei, TaiwanChia-Yang Hsu, Faculty of Medicine, National Yang-Ming University, Taipei, TaiwanYi-Hsiang Huang, Institute of Clinical Medicine, National Yang-Ming University, Taipei, TaiwanChien-Wei Su, Faculty of Medicine, National Yang-Ming University, Taipei, TaiwanHan-Chieh Lin, Faculty of Medicine, National Yang-Ming University, Taipei, TaiwanRheun-Chuan Lee, Faculty of Medicine, National Yang-Ming University, Taipei, TaiwanJen-Huey Chiang, Faculty of Medic... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4783492 Sat, 30 Apr 2011 05:55:28 +0100 4783492 The dissociation between the diabetes and both Child–Pugh score and in-hospital mortality in cirrhotic patients due to hepatitis B, hepatitis C, or alcoholic http://www.medworm.com/index.php?rid=4745353&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F707871q176034l11%2F Conclusion  The prevalence of diabetes was higher in cirrhotic patients in Taiwan. The prevalence of diabetes was dissociated with Child–Pugh or MELD score. The diagnosis of diabetes did not affect the renal function or in-hospital mortality in cirrhotic patients. Since the clinical outcomes of diabetes were different from cirrhotic patients to general population, it is unclear whether the treatment of diabetes and improved glycemic control will benefit cirrhotic patients. Content Type Journal ArticlePages 1-10DOI 10.1007/s12072-011-9274-yAuthors Yu-Wei Chen, Division of Nephrology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, TaiwanHan-Hsiang Chen, Division of Nephrology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Tai... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4745353 Wed, 20 Apr 2011 06:10:53 +0100 4745353 Clinical features of clinically diagnosed eosinophilic liver abscesses http://www.medworm.com/index.php?rid=4687386&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk66w137553734141%2F Conclusions  Clinically diagnosed ELA adopts a relatively benign course. Empirical anti-parasitic treatment in patients without an identified etiology may shorten the duration of clinically diagnosed ELA. Content Type Journal ArticlePages 1-6DOI 10.1007/s12072-011-9272-0Authors Jae-Woo Kwon, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South KoreaTae-Wan Kim, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South KoreaKyung-Mook Kim, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South KoreaSo-Hee Lee, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South KoreaSang-Heon Cho, Department of Internal Medicine, Seou... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4687386 Tue, 05 Apr 2011 16:58:39 +0100 4687386 Differences in the factors associated with serum viral load between genotypes 1 and 2 in patients with chronic hepatitis C http://www.medworm.com/index.php?rid=4687387&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn2r36p3065512068%2F Conclusions  These results suggest that viral kinetics is affected by different host factors for genotypes 1 and 2. Content Type Journal ArticlePages 1-8DOI 10.1007/s12072-011-9273-zAuthors Shunsuke Sato, Department of Gastroenterology and Hepatology, Juntendo University Shizuoka Hospital, Shizuoka, JapanTakuya Genda, Department of Gastroenterology and Hepatology, Juntendo University Shizuoka Hospital, Shizuoka, JapanKatsuharu Hirano, Department of Gastroenterology and Hepatology, Juntendo University Shizuoka Hospital, Shizuoka, JapanHironori Tsuzura, Department of Gastroenterology and Hepatology, Juntendo University Shizuoka Hospital, Shizuoka, JapanYoshio Kanemitsu, Department of Gastroenterology and Hepatology, Juntendo University Shizuoka Hospital, Shizuoka, JapanYut... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4687387 Sun, 03 Apr 2011 05:43:46 +0100 4687387 Hepatic involvement by lymphoproliferative disorders post liver transplantation: PTLD.Int. Survey http://www.medworm.com/index.php?rid=4665771&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc635w17m53485812%2F Conclusions  Liver transplant patients exhibiting early deterioration of graft function or other hepatic symptoms should, in addition to assessment for rejection, be evaluated for H-PTLD. In addition, all H-PTLD patients should be evaluated for bone marrow involvement, especially if they are EBV positive. Prospective studies with large patient populations are needed to confirm our results. Content Type Journal ArticlePages 1-8DOI 10.1007/s12072-011-9271-1Authors Morteza Izadi, Health Research Center, Baqiyatallah University of Medical Sciences, Tehran, IranMozhgan Fazel, International Travel Medicine Center of Iran, Tehran, IranSeyed Hasan Saadat, Health Research Center, Baqiyatallah University of Medical Sciences, Tehran, IranSaeed Taheri, Dr. Taheri Medical Researc... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4665771 Tue, 29 Mar 2011 06:07:58 +0100 4665771 Acute kidney injury as a causal factor in mortality associated with hepatorenal syndrome http://www.medworm.com/index.php?rid=4654765&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F532423643x550822%2F Abstract Purpose  We examine how acute kidney injury (AKI) contributes to mortality in patients with liver failure. Content  Hepatorenal syndrome (HRS) is a form of AKI in cirrhotic patients, which is defined as a purely physiologic derangement in renal function without any effect on renal parenchyma. Recent literature challenges this understanding. Little attention is paid to the presence of renal pathology and inflammatory alterations that occur as a result of HRS and their contribution to morbidity and mortality. In this paper, we propose that any type of AKI in the presence of liver disease is an inflammatory condition. The combination of AKI and liver failure produces a “toxic milieu” of cytokines, chemokines, and nitric oxide pathway metabolites t... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4654765 Sun, 27 Mar 2011 05:43:34 +0100 4654765 Validation of graft and standard liver size predictions in right liver living donor liver transplantation http://www.medworm.com/index.php?rid=4645687&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Feqm88487461mh244%2F Conclusion  SLV and graft weight estimations were accurate using the formula and conversion factor. Content Type Journal ArticlePages 1-5DOI 10.1007/s12072-011-9264-0Authors See Ching Chan, Department of Surgery, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, ChinaChung Mau Lo, Department of Surgery, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, ChinaKenneth S. H. Chok, Department of Surgery, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, ChinaWilliam W. Sharr, Department of Surgery, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, ChinaTan To Cheung, Department of Surgery, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, ChinaSimon H. Y. Tsang, Department of Surgery, The University of Hong Kong, 102 Pokfulam Road,... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4645687 Fri, 25 Mar 2011 18:51:51 +0100 4645687 Serum hepatitis B virus DNA before liver transplantation correlates with HBV reinfection rate even under successful low-dose hepatitis B immunoglobulin prophylaxis http://www.medworm.com/index.php?rid=4645688&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh1612r3r3159r472%2F Conclusions  Patients with high serum HBV-DNA and HBcrAg levels before OLT (particularly >3 log10 copies/mL and >4 log10 IU/mL, respectively) should be followed with care for HBV recurrence. Content Type Journal ArticlePages 1-9DOI 10.1007/s12072-011-9265-zAuthors Tetsuya Yasunaka, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, JapanAkinobu Takaki, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, JapanTakahito Yagi, Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, JapanYoshiaki Iwasaki, H... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4645688 Fri, 25 Mar 2011 05:51:39 +0100 4645688 Lidocaïne test for easier and less time consuming assessment of liver function in several hepatic injury models http://www.medworm.com/index.php?rid=4632808&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fww763n502056871h%2F Conclusion  Our method provides reliable and reproducible results using only a small portion of liver which allows for a fast and easy assessment of liver metabolic capacity. Moreover, our method presents an alternative to the in vivo technique and seems more feasible in a clinical setting. Content Type Journal ArticlePages 1-8DOI 10.1007/s12072-011-9270-2Authors Dorra Ben Said, Service de Pharmacologie Clinique, Centre National de Pharmacovigilance, Tunis, TunisiaRidha Ben Ali, Service de Pharmacologie Clinique, Centre National de Pharmacovigilance, Tunis, TunisiaHenda Ferchichi, Service de Pharmacologie Clinique, Centre National de Pharmacovigilance, Tunis, TunisiaIssam Salouage, Service de Pharmacologie Clinique, Centre National de Pharmacovigilance, Tunis, Tunisi... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4632808 Wed, 23 Mar 2011 06:08:00 +0100 4632808 Is interleukin-8 an additional to histopathological changes diagnostic marker in HCV-infected patients with cryoglobulinemia? http://www.medworm.com/index.php?rid=4617401&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F574883r862n3n572%2F Conclusions  The serum levels of all proinflammatory cytokines, especially IL-8, were significantly higher in the patients with cryoglobulinemia in comparison with the patients without cryoglobulinemia and healthy persons. All microscopic features did not correlate with the level of any investigated proinflammatory cytokines. Content Type Journal ArticlePages 1-7DOI 10.1007/s12072-011-9268-9Authors Joanna Cielecka-Kuszyk, Department of Virology, National Institute of Public Health, National Institute of Hygiene, 24, Chocimska Street, 00-791 Warsaw, PolandJoanna Siennicka, Department of Virology, National Institute of Public Health, National Institute of Hygiene, 24, Chocimska Street, 00-791 Warsaw, PolandJoanna Jabłońska, Department of Hepatology and Acquired Immun... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4617401 Sun, 20 Mar 2011 05:32:42 +0100 4617401 Analysis of the complete open reading frame of hepatitis C virus in genotype 2a infection reveals critical sites influencing the response to peginterferon and ribavirin therapy http://www.medworm.com/index.php?rid=4617402&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe43003w2473854t1%2F Conclusions  The outcome of PEG-IFN/RBV therapy is significantly influenced by variation in the core and NS5A regions in genotype 2a HCV infection. Content Type Journal ArticlePages 1-11DOI 10.1007/s12072-011-9267-xAuthors Makoto Kadokura, First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, 1110, Shimokato, Chuo, Yamanashi 409-3898, JapanShinya Maekawa, First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, 1110, Shimokato, Chuo, Yamanashi 409-3898, JapanRyota Sueki, First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, 1110, Shimokato, Chuo, Yamanashi 409-3898, JapanMika Miura, First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, 1110, Shimoka... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4617402 Sat, 19 Mar 2011 16:59:45 +0100 4617402 HBV/A and HBV/C genotype predominance among patients with chronic hepatitis B virus infection in Cebu City, Philippines http://www.medworm.com/index.php?rid=4617403&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc7g1773036k48324%2F Conclusion  HBV/A and HBV/C genotypes are equally predominant among Filipino patients with Chronic HBV infection seen in two specialty clinics in Cebu City, Philippines. Content Type Journal ArticlePages 1-8DOI 10.1007/s12072-011-9263-1Authors Karen S. Batoctoy, Section of Gastroenterology, Department of Internal Medicine, Cebu Doctors’ University Hospital, Cebu City, The PhilippinesTai-Chung Tseng, Division of Hepatogastroenterology, Department of Internal Medicine, Buddhist Tzu Chi General Hospital Taipei Branch, Taipei, TaiwanJia-Horng Kao, Division of Gastroenterology, Department of Internal Medicine, Graduate Institute of Clinical Medicine; Hepatitis Research Center, Tapei, TaiwanFidelis E. Quiza, Clinico-Epidemiology Unit, Cebu Institute of Medicine, Cebu City... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4617403 Sat, 19 Mar 2011 06:35:09 +0100 4617403 Cystatin C: a predictor of hepatorenal syndrome in patients with liver cirrhosis http://www.medworm.com/index.php?rid=4596679&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6372rxt081422p82%2F Conclusion  Serum CysC level may be considered a predictor of HRS and mortality in patients with liver cirrhosis and ascites. Content Type Journal ArticlePages 1-7DOI 10.1007/s12072-011-9266-yAuthors Mohammed A. Sharawey, Department of Internal Medicine, Faculty of Medicine, Minia University, El-Minia, EgyptEglal M. Shawky, Department of Internal Medicine, Faculty of Medicine, Minia University, El-Minia, EgyptLamia H. Ali, Department of Clinical Pathology, Faculty of Medicine, Minia University, El-Minia, EgyptAhmed Ali Mohammed, Department of Internal Medicine, Faculty of Medicine, Minia University, El-Minia, EgyptHatem A. Hassan, Department of Internal Medicine, Faculty of Medicine, Minia University, El-Minia, EgyptYasser M. Fouad, Department of Tropical Medicine, Facul... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4596679 Sat, 12 Mar 2011 07:00:52 +0100 4596679 Natural history of small duct primary sclerosing cholangitis: a case series with review of the literature http://www.medworm.com/index.php?rid=4578701&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe764tl32n5h6r2g5%2F Conclusions  SDPSC, a mild disease at presentation typically runs a benign course and likely is not an early stage of classic PSC. Further studies with a control group of classic PSC and longer follow-up are needed to study the natural history of SDPSC. Content Type Journal ArticlePages 1-6DOI 10.1007/s12072-011-9260-4Authors A. K. Singal, Department of Gastroenterology, University of Texas Medical Branch, Galveston, TX USAC. M. Stanca, Department of Liver Diseases, Mount Sinai Medical Center, New York, NY USAV. Clark, Department of Gastroenterology, Hepatology, Nutrition, University of Florida, Gainesville, FL USAL. Dixon, Department of Pathology, University of Florida, Gainesville, FL USAC. Levy, Department of Gastroenterology, Hepatology, Nutrition, University of F... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4578701 Thu, 10 Mar 2011 17:13:34 +0100 4578701 HBV life cycle and novel drug targets http://www.medworm.com/index.php?rid=4578702&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F574k604k1802783m%2F Abstract  With up to 400 million affected people worldwide, chronic hepatitis B virus (HBV) infection is still a major health care problem. During the last decade, several novel therapeutic approaches have been developed and evaluated. In most regions of the world, interferon-α, and nucleos(t)ide analogues (NUCs) are currently approved. Despite major improvements, none of the existing therapies is optimal since viral clearance is rarely achieved. Recently, a better understanding of the HBV life cycle and the development of novel model systems of HBV infection have led to the development of novel antiviral strategies and drug targets. This review will focus on current and potential future drug targets in the HBV life cycle and strategies to modulate the virus–host interac... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4578702 Tue, 08 Mar 2011 06:44:12 +0100 4578702 Serum retinol binding protein 4 and clinical outcome in postoperative biliary atresia http://www.medworm.com/index.php?rid=4562250&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F34p8404415q265hh%2F Conclusion  Serum RBP4 levels decreased in BA patients compared with normal participants, and its levels declined significantly in patients with more severe disease. RBP4 may play a role in the pathogenesis of hepatic fibrosis and serve as a possible biomarker reflecting disease severity in postoperative BA patients. Content Type Journal ArticlePages 1-7DOI 10.1007/s12072-011-9262-2Authors Maneerat Chayanupatkul, Department of Physiology, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330 ThailandSittisak Honsawek, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330 ThailandVoranush Chongsrisawat, Department of Pediatrics, Faculty of Medicine, Centre of Excellence in Clinical Virology, Chulalongkorn University, Bangkok... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4562250 Sat, 05 Mar 2011 16:51:56 +0100 4562250 Diagnosis and management of acute variceal bleeding: Asian Pacific Association for Study of the Liver recommendations http://www.medworm.com/index.php?rid=4503285&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3782853x58334m79%2F Conclusion  Management of acute variceal bleeding in Asia–Pacific region needs special attention for uniformity of treatment and future clinical trials. Content Type Journal ArticlePages 1-18DOI 10.1007/s12072-010-9236-9Authors Shiv Kumar Sarin, Department of Hepatology, Institute of Liver and Biliary Sciences (ILBS), New Delhi, IndiaAshish Kumar, Department of Hepatology, Institute of Liver and Biliary Sciences (ILBS), New Delhi, IndiaPeter W. Angus, Department of Gastroenterology, Austin Health, Studley Rd, Heidelberg, 3084 AustraliaSanjay Saran Baijal, Department of Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow, 226014 IndiaSoon Koo Baik, Division of Gastroenterology and Hepatology, Department of Internal Medic... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4503285 Fri, 18 Feb 2011 17:24:07 +0100 4503285 Pre-transplant MELD and sodium MELD scores are poor predictors of graft failure and mortality after liver transplantation http://www.medworm.com/index.php?rid=4503287&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9778u36783252t36%2F Conclusion  While MELD and sodium MELD were each significantly associated with survival after OLT, their predictive abilities were poor. The sodium MELD score does not improve prediction accuracy over the MELD score. Weak prediction may result from unaccounted variability in recipient and donor status, as well as surgical and postoperative factors. Content Type Journal ArticlePages 1-9DOI 10.1007/s12072-011-9257-zAuthors Jacek B. Cywinski, Departments of General Anesthesiology and Outcomes Research, Transplantation Center, Cleveland Clinic, Cleveland, OH USAEdward J. Mascha, Departments of Quantitative Health Sciences and Outcomes Research, Cleveland Clinic, Cleveland, OH USAJing You, Departments of Quantitative Health Sciences and Outcomes Research, Cleveland Clinic... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4503287 Thu, 17 Feb 2011 08:11:25 +0100 4503287 Successful liver transplantation for Rendu–Weber–Osler disease, a single centre experience http://www.medworm.com/index.php?rid=4503286&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh64531514025g648%2F Conclusions  Despite new advances in immunotherapy for the medical treatment of Rendu–Weber–Osler disease, liver transplantation remains the curative option for hepatic based-hereditary hemorrhagic telangiectasia. Content Type Journal ArticlePages 1-7DOI 10.1007/s12072-011-9259-xAuthors Murat Cag, Pôle des Pathologies Digestives, Hépatiques et de la Transplantation, Hôpital de Hautepierre, Strasbourg, FranceMaxime Audet, Pôle des Pathologies Digestives, Hépatiques et de la Transplantation, Hôpital de Hautepierre, Strasbourg, FranceAnne-Catherine Saouli, Pôle des Pathologies Digestives, Hépatiques et de la Transplantation, Hôpital de Hautepierre, Strasbourg, FranceMurad Odeh, Pôle des Pathologies Digestives, Hépatiques et de la Transplantation, Hôpital ... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4503286 Thu, 17 Feb 2011 08:11:25 +0100 4503286 Risk factors for mortality in cirrhotic patients with sepsis http://www.medworm.com/index.php?rid=4484964&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv0v7v812978q0031%2F Conclusions  Septic cirrhotic patients with pneumonia, >1 site of infection, Child’s C cirrhosis, and high MELD score had a high mortality risk. Content Type Journal ArticlePages 1-8DOI 10.1007/s12072-011-9258-yAuthors Lee-Guan Lim, Department of Gastroenterology and Hepatology, National University Health System, Singapore, SingaporeXiang-Xuan Eunice Tan, National University of Singapore High School, Singapore, SingaporeShu-Jeng Woo, Department of Gastroenterology and Hepatology, National University Health System, Singapore, SingaporeYock-Young Dan, Department of Gastroenterology and Hepatology, National University Health System, Singapore, SingaporeYin-Mei Lee, Department of Gastroenterology and Hepatology, National University Health System, Singapore, Singapore... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4484964 Mon, 14 Feb 2011 07:13:41 +0100 4484964 Protective effect of probucol on liver injury induced by carbon tetrachloride in rats http://www.medworm.com/index.php?rid=4471215&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F66n9t183t8046800%2F Conclusions  For the first time, we demonstrated that probucol has protective effect against liver injury in animal experiment. The antioxidant action of probucol may play an important role in its hepatoprotective mechanism. Probucol also can reduce serum cholesterol. Thus, probucol may have the potential use in clinical liver diseases in which oxidative stress may be present, especially for the patients with hypercholesterolemia. Content Type Journal ArticlePages 1-7DOI 10.1007/s12072-011-9256-0Authors Yu-Tao Zhan, Department of Gastroenterology and Hepatology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730 People’s Republic of ChinaJing Weng, Reproductive Medicine Centre, Capital Medical University, Beijing, 100069 People’s Republic of C... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4471215 Thu, 10 Feb 2011 06:55:33 +0100 4471215 Combined effect of pro- and anti-inflammatory cytokine gene polymorphisms on susceptibility to liver cirrhosis in Tunisian HCV-infected patients http://www.medworm.com/index.php?rid=4461276&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7944749104980647%2F Conclusion  Our study showed that the co-inheritance of IL-18, IFN-γ and IL-10 specific high-risk genotypes is associated with a greater risk for liver cirrhosis. Content Type Journal ArticlePages 1-7DOI 10.1007/s12072-010-9232-0Authors Nadia Bouzgarrou, Molecular Immuno-oncology Laboratory, Faculty of Medicine, Monastir, TunisiaElham Hassen, Molecular Immuno-oncology Laboratory, Faculty of Medicine, Monastir, TunisiaOlfa Bahri, Clinical Virology Laboratory, Pasteur Institute, Tunis, TunisiaSallouha Gabbouj, Molecular Immuno-oncology Laboratory, Faculty of Medicine, Monastir, TunisiaNabil Ben Mami, Gastroenterology B Unit, La Rabta Hospital, Tunis, TunisiaHenda Triki, Clinical Virology Laboratory, Pasteur Institute, Tunis, TunisiaLotfi Chouchane, Molecular Immuno-onc... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4461276 Mon, 07 Feb 2011 22:02:40 +0100 4461276 Serum p53 gene polymorphisms and severity of hepatitis B or C-related chronic liver diseases in Taiwan http://www.medworm.com/index.php?rid=4451796&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw4x2564262jm190t%2F Conclusions  Although serum 249serine p53 mutation is rarely found in Taiwanese patients, HBV carriers have a higher prevalence of codon 72 mutants than patients with much severe liver diseases or HCV infection, which implies that codon 72 mutants may affect at an earlier stage of HBV infection. Further studies are necessary to delineate the interactions of p53 mutations with HBV infection. Content Type Journal ArticlePages 1-8DOI 10.1007/s12072-010-9248-5Authors Yone-Han Mah, Division of Gastroenterology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, TaiwanChing-Sheng Hsu, Division of Gastroenterology, Department of Internal Medicine, Buddhist Tzu Chi General Hospital, Taipei Branch, ... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4451796 Sun, 06 Feb 2011 06:36:49 +0100 4451796 Direct differentiation of hepatic cells from human induced pluripotent stem cells using a limited number of cytokines http://www.medworm.com/index.php?rid=4451797&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb0321u7955v3q1l4%2F Conclusions  Developing efficient induction and culture methods to generate more highly matured hepatocytes is essential for regenerative cell-based therapies. Our protocol provides a simple, cost-effective, and time-saving approach for generating hepatic cells from iPS cells. Content Type Journal ArticlePages 1-9DOI 10.1007/s12072-011-9251-5Authors Akemi Takata, Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanMotoyuki Otsuka, Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanTomomi Kogiso, Department of Medicine and Institute of Gastroenterology, Tokyo Women’s Medical University, Tokyo, JapanKentaro Kojima, Department of Gastroenterology, Graduate School of Medicine, ... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4451797 Sat, 05 Feb 2011 16:56:46 +0100 4451797 Hepatitis C virus infection among patients with non-Hodgkin’s lymphoma in northern India http://www.medworm.com/index.php?rid=4430071&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fdxr21nu776674585%2F Conclusions  HCV infection is unlikely to be associated with lymphoproliferative disorders in northern India and does not play a major role in the pathogenesis of lymphoproliferative disorders. Content Type Journal ArticlePages 1-5DOI 10.1007/s12072-010-9244-9Authors Subhash Varma, Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012 IndiaMadhav C. Menon, Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012 IndiaAshish Garg, Department of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012 IndiaPankaj Malhotra, Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012 ... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4430071 Sat, 29 Jan 2011 17:20:19 +0100 4430071 Renal function and severity of bright liver. Relationship with insulin resistance, intrarenal resistive index, and glomerular filtration rate http://www.medworm.com/index.php?rid=4430072&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F780430625j64825w%2F Conclusion  Greater RRI, abdominal obesity, and greater BLS account for a lower GFR in NAFLD patients suggesting the hypothesis that inter-related factors can be operating early in the natural history of obesity-related kidney and liver disease. Content Type Journal ArticlePages 1-8DOI 10.1007/s12072-011-9254-2Authors Daniela Catalano, Dipartimento di Medicina Interna, Istituto di Medicina Interna e Terapia Medica, Facoltà di Medicina e Chirurgia, Università di Catania, Catania, ItalyGuglielmo M. Trovato, Dipartimento di Medicina Interna, Istituto di Medicina Interna e Terapia Medica, Facoltà di Medicina e Chirurgia, Università di Catania, Catania, ItalyGiuseppe Fabio Martines, Dipartimento di Medicina Interna, Istituto di Medicina Interna e Terapia Medica, Facolt... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4430072 Fri, 28 Jan 2011 06:55:27 +0100 4430072 Coffee prevents CCl4-induced liver cirrhosis in the rat http://www.medworm.com/index.php?rid=4412581&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj38t2573hl6u4276%2F Conclusions  Our results suggest (1) that coffee plays a causative role in preventing cirrhosis (at least experimental cirrhosis); (2) that action mechanisms are probably associated with down regulation of the profibrogenic cytokine TGF-β and to its antioxidant properties and, (3) that GC is more potent than SC. These findings suggest a beneficial effect of coffee on the liver. However, more clinical and basic studies must be performed before reaching a final recommendation. Content Type Journal ArticlePages 1-7DOI 10.1007/s12072-010-9247-6Authors Mario G. Moreno, Departamento de Farmacología, Cinvestav-IPN, Apdo. Postal 14-740, 07000 México, DF MéxicoEnrique Chávez, Departamento de Farmacología, Cinvestav-IPN, Apdo. Postal 14-740, 07000 México, DF MéxicoLise... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4412581 Tue, 25 Jan 2011 06:45:43 +0100 4412581 Influence of serum HBV DNA load on recurrence of hepatocellular carcinoma after treatment with percutaneous radiofrequency ablation http://www.medworm.com/index.php?rid=4412582&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fhq8n973832236817%2F Conclusion  Serum HBV DNA load is associated with the risk of recurrence of HBV-related HCC after RFA. Content Type Journal ArticlePages 1-7DOI 10.1007/s12072-011-9255-1Authors Tadashi Goto, Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 JapanHaruhiko Yoshida, Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 JapanRyosuke Tateishi, Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 JapanKenichiro Enooku, Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 JapanEriko Goto, ... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4412582 Tue, 25 Jan 2011 06:45:41 +0100 4412582 Current use of hepatitis B immune globulin for prevention of de novo hepatitis B in recipients receiving anti-HBc-positive livers http://www.medworm.com/index.php?rid=4401509&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft8552q2j64313422%2F Abstract  Livers from donors positive for antibody against anti-HBc can potentially transmit de novo hepatitis B (DNH) to their recipients. Despite a good outcome, prophylaxis is usually offered to such recipients. There is no consensus on the standard prophylactic regimen and hence prophylaxis varies among different transplant centres. Nonetheless, hepatitis B immune globulin (HBIG) is considered the mainstay of such prophylaxis, either alone or in combination with an oral antiviral treatment. We aim to provide a concise review of the current use of HBIG in prevention of DNH. We also address a few important questions regarding HBIG use. Content Type Journal ArticlePages 1-9DOI 10.1007/s12072-010-9250-yAuthors Jen-Jung Pan, Division of Gastroenterology, Hepatology and... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4401509 Sat, 22 Jan 2011 07:32:41 +0100 4401509 Safety and tolerance of sorafenib in Japanese patients with advanced hepatocellular carcinoma http://www.medworm.com/index.php?rid=4401510&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj1751p2048133006%2F Conclusions  These data suggest that sorafenib is generally tolerated in Japanese patients with HCC. Nevertheless, the majority needed a dose reduction. Adverse events including HFSR, rash, and liver failure occurred more frequently in our patients than those reported elsewhere. Careful attention must be paid to these adverse events during sorafenib administration. Content Type Journal ArticlePages 1-7DOI 10.1007/s12072-010-9249-4Authors Sadahisa Ogasawara, Department of Medicine and Clinical Oncology, Graduate School of Medicine, University of Chiba, 1-8-1 Inohana, Chuo-ku, 260-8670 Chiba, JapanFumihiko Kanai, Department of Medicine and Clinical Oncology, Graduate School of Medicine, University of Chiba, 1-8-1 Inohana, Chuo-ku, 260-8670 Chiba, JapanShuntaro Obi, Dep... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4401510 Sat, 22 Jan 2011 07:32:40 +0100 4401510 Gene profiling of early and advanced liver disease in chronic hepatitis C patients http://www.medworm.com/index.php?rid=4401511&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr37n311g1q134810%2F Conclusion  The results of this study reflect the changes taking place during the transition from early to advanced liver fibrosis, when the liver function becomes impaired and extracellular matrix deposition increases. In addition, it showed altered expression of genes with functions in cancer development, cell growth, proliferation, and cell death that might indicate high risk of cell transformation and hepatocellular carcinoma (HCC) in A-HCV disease patients. Content Type Journal ArticlePages 1-7DOI 10.1007/s12072-011-9252-4Authors Saira Sarfraz Khalid, Department of Biological and Biomedical Sciences, Aga Khan University Hospital, Juma Research Building, Stadium Road, Karachi, PakistanSaeed Hamid, Department of Medicine, Aga Khan University Hospital, Stadium Roa... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4401511 Sat, 22 Jan 2011 07:32:37 +0100 4401511 Non-invasive assessment of liver fibrosis in chronic hepatitis C http://www.medworm.com/index.php?rid=4401512&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F86x027348p7k6556%2F Abstract  Quantification of hepatic fibrosis is of critical importance in chronic hepatitis C not only for prognosis, but also for antiviral treatment indication. Two end points are clinically relevant: detection of significant fibrosis (indication for antiviral treatment) and detection of cirrhosis (screening for eosphageal varices and hepatocellular carcinoma). Until recently, liver biopsy was considered the reference method for the evaluation of liver fibrosis. Limitations of liver biopsy (invasiveness, sampling error, and inter-observer variability) have led to the development of non-invasive methods. Currently available methods rely on two different approaches: a “biological” approach based on the dosage of serum fibrosis biomarkers; and a “physical” approach b... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4401512 Thu, 20 Jan 2011 07:09:27 +0100 4401512 De novo combination of lamivudine and adefovir versus entecavir monotherapy for the treatment of naïve HBeAg-negative chronic hepatitis B patients http://www.medworm.com/index.php?rid=4383813&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr12p178743885649%2F Conclusions  Both LAM + ADV combination therapy and ETV monotherapy are effective in naïve HBeAg-negative CHB patients, but further studies are needed to obtain long-term results. Content Type Journal ArticlePages 1-6DOI 10.1007/s12072-010-9243-xAuthors Li-Chun Wang, Centre of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, ChinaEn-Qiang Chen, Centre of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, ChinaJing Cao, Information Centre, Sichuan Provincial Hospital for Women and Children, Chengdu, ChinaLi Liu, Centre of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, ChinaLi Zheng, Centre of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, ChinaDa-Jiang Li, Centre of Inf... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4383813 Tue, 18 Jan 2011 19:38:20 +0100 4383813 Nonleukemic myeloid sarcoma of the liver: a case report and review of literature http://www.medworm.com/index.php?rid=4364008&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5j24829t855m7263%2F This report describes an unusual case of nonleukemic MS of the liver in a 16-year-old patient presenting as debilitating hepatomegaly. A liver biopsy revealed diffuse infiltration by neoplastic cells of myeloid lineage (CD68, myeloperoxidase). A bone marrow biopsy showed no evidence of medullary involvement. The patient subsequently developed heart failure. Autopsy revealed infiltration of most organs by neoplastic cells but failed to identify abnormal myeloid cells in bone marrow. Content Type Journal ArticlePages 1-4DOI 10.1007/s12072-010-9233-zAuthors Xiao-Feng Hang, Department of Infectious Diseases, Changzheng Hospital, Second Military Medical University, Shanghai, 200003 ChinaHai-Guang Xin, Department of Infectious Diseases, Changzheng Hospital, Second Military Medical Uni... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4364008 Sat, 15 Jan 2011 06:58:47 +0100 4364008 Acknowledgements http://www.medworm.com/index.php?rid=4364009&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc846567066710p16%2F Content Type Journal ArticlePages 1-2DOI 10.1007/s12072-011-9253-3 Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=4364009 Sat, 15 Jan 2011 06:58:44 +0100 4364009 The clinical consequences of utilizing donation after cardiac death liver grafts into hepatitis C recipients http://www.medworm.com/index.php?rid=4364010&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg7l6x141h7274277%2F Conclusion  Although a statistically significant difference in patient/graft survival for HCV and non-HCV recipients of DCD organs was not shown, it is clear that more dire consequences exist for HCV recipients of DCD grafts, highlighting the need for larger data sets for evaluating this patient population Content Type Journal ArticlePages 1-4DOI 10.1007/s12072-010-9242-yAuthors Mohammad Mawardi, Multi-Organ Transplant Program, University Hospital, London Health Sciences Centre, 339 Windermere Road, London, ON N6A 5A5, CanadaFaisal Aba Alkhail, Multi-Organ Transplant Program, University Hospital, London Health Sciences Centre, 339 Windermere Road, London, ON N6A 5A5, CanadaKazuhiro Katada, Multi-Organ Transplant Program, University Hospital, London Health Sciences Ce... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4364010 Sat, 15 Jan 2011 00:56:58 +0100 4364010 Non-cirrhotic portal fibrosis related end stage liver disease in adults: evaluation from a study on living donor liver transplant recipients http://www.medworm.com/index.php?rid=4346152&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl8212h3058168562%2F Conclusions  The study concludes that in our population, NCPF constitutes about 5% of the subset of end stage CLD considered eligible for liver transplantation (LT), presenting mostly as cryptogenic cirrhosis (CC). A diagnosis of NCPF should be considered when patients presumed to have cryptogenic or other cirrhosis become eligible for LT even in the presence of relatively well-preserved liver function and low MELD scores. End stage CLD manifests at earlier age, when cirrhosis of another etiology supervenes on pre-existent NCPF. Content Type Journal ArticlePages 1-8DOI 10.1007/s12072-010-9246-7Authors Sanjiv Saigal, Department of Liver Transplant, Sir Ganga Ram Hospital, New Delhi, IndiaNabeen C. Nayak, Department of Pathology, Sir Ganga Ram Hospital, New Delhi, In... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4346152 Tue, 11 Jan 2011 18:05:18 +0100 4346152 Assessment of hepatocellular carcinomas using conventional magnetic resonance imaging correlated with histological differentiation and a serum marker of poor prognosis http://www.medworm.com/index.php?rid=4346153&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd8717712x5r3154j%2F Conclusions  Although hyperintensity of tumor on T2-weighted imaging and arterial hypervascularity of tumor are considered to be useful for differential diagnosis between well differentiated HCCs and moderately/poorly differentiated HCCs, hypointensity of tumor on T1-weighted imaging and tumor stain washout during the portal phase of Gd-DTPA dynamic MRI reflected poorer histological differentiation of HCCs and correlated with AFP-L3 levels. Content Type Journal ArticlePages 1-8DOI 10.1007/s12072-010-9245-8Authors Shotaro Enomoto, Second Department of Internal Medicine, Wakayama Medical University, 811-1 Kimiidera Wakayama City, Wakayama, 641-0012 JapanHideyuki Tamai, Second Department of Internal Medicine, Wakayama Medical University, 811-1 Kimiidera Wakayama City, ... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4346153 Mon, 10 Jan 2011 15:54:09 +0100 4346153 Differential response related to genotoxicity in multiple organs of cirrhotic rats http://www.medworm.com/index.php?rid=4323154&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg41l42m30n376827%2F Conclusions  In conclusion, our results suggest that cirrhosis could contribute to DNA damage in liver and brain cells. Content Type Journal ArticlePages 1-7DOI 10.1007/s12072-010-9239-6Authors Marcia R. Nagaoka, Departamento de Biociências, Universidade Federal de Sao Paulo, UNIFESP, Santos, SP BrazilLuciana Le Sueur-Maluf, Departamento de Biociências, Universidade Federal de Sao Paulo, UNIFESP, Santos, SP BrazilOdair Aguiar, Departamento de Biociências, Universidade Federal de Sao Paulo, UNIFESP, Santos, SP BrazilGlaucia M. Castro, Departamento de Biociências, Universidade Federal de Sao Paulo, UNIFESP, Santos, SP BrazilRegina C. Spadari-Bratfisch, Departamento de Biociências, Universidade Federal de Sao Paulo, UNIFESP, Santos, SP BrazilDaniel A. Ribeiro, Departam... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4323154 Wed, 05 Jan 2011 16:52:35 +0100 4323154 Extended treatment with lamivudine and adefovir dipivoxil in chronic hepatitis B patients with lamivudine resistance http://www.medworm.com/index.php?rid=4319497&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F84l5321435qj63v0%2F Conclusions  The combination of lamivudine and adefovir for 2 years generally proved effective in lamivudine-resistant cases, but there was a persistently high rate of detection of lamivudine resistant mutants and impaired virologic response in compensated patients. Content Type Journal ArticleDOI 10.1007/s12072-010-9228-9Authors Robert P. Perrillo, Baylor University Medical Center, Dallas, TX USAHie-Won Hann, Jefferson Medical College, Philadelphia, PA USAEugene Schiff, University of Miami, Miami, FL USADavid Mutimer, Queen Elizabeth Hospital, Birmingham, UKBernard Willems, Hospital Saint Luc, Montreal, CanadaNancy Leung, Alice Ho Miu Ling Nethersole Hospital, Hong Kong, ChinaWilliam M. Lee, University of Texas Southwestern Medical Center, Dallas, TX USASusan Di... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4319497 Tue, 04 Jan 2011 17:54:57 +0100 4319497 A comparison of 48-week treatment efficacy between clevudine and entecavir in treatment-naïve patients with chronic hepatitis B http://www.medworm.com/index.php?rid=4303247&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fqt96176881w83726%2F Conclusion  Mean reduction of viral loads was similar between clevudine and entecavir groups during 48 weeks. However, virologic breakthrough and significant myopathy were noted only in clevudine-treated patients. Therefore, more attention should be paid to patients receiving clevudine. Content Type Journal ArticleDOI 10.1007/s12072-010-9238-7Authors Su Rin Shin, Department of Medicine, Kangnam Sacred Heart Hospital, Hallym University, Seoul, KoreaByung Chul Yoo, Department of Medicine, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, KoreaMoon Seok Choi, Department of Medicine, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, KoreaDong Ho Lee, Digestive Disease Research Centre, Samsung Medical Centre, Seoul, K... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4303247 Fri, 31 Dec 2010 18:04:09 +0100 4303247 Vertical transmission of hepatitis C virus in low to middle socio-economic pregnant population of Karachi http://www.medworm.com/index.php?rid=4302435&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj672046n773383w4%2F Conclusion  In spite of the high hepatitis C positivity in pregnant population, the rate of vertical transmission to the neonate is low. Content Type Journal ArticleDOI 10.1007/s12072-010-9229-8Authors Sina Aziz, Sarwar Zuberi Liver Centre, Civil Hospital Karachi, Dow University of Health Sciences, Karachi, Sindh PakistanNazli Hossain, Gynaecology and Obstetrics, Civil Hospital Karachi, Dow University of Health Sciences, Karachi, Sindh PakistanSaadiya Aziz Karim, Gynaecology and Obstetrics, Abbasi Shaheed Hospital, Karachi Medical and Dental College, Karachi, Sindh PakistanJamila Rajper, Sarwar Zuberi Liver Centre, Civil Hospital Karachi, Dow University of Health Sciences, Karachi, Sindh PakistanNargis Soomro, Gynaecology and Obstetrics, Civil Hospital Karachi, Dow Unive... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4302435 Thu, 30 Dec 2010 18:05:02 +0100 4302435 Expression level of glutamine synthetase is increased in hepatocellular carcinoma and liver tissue with cirrhosis and chronic hepatitis B http://www.medworm.com/index.php?rid=4301179&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff111p5q4h7714888%2F Abstract  Studies have suggested that glutamine synthetase (GS) is a potential marker of hepatocellular carcinoma (HCC). We aimed to evaluate the expression of GS in non-malignant liver tissue and serum GS levels in HCC, liver cirrhosis (LC), chronic hepatitis B (CHB), five kinds of extrahepatic diseases patients and healthy subjects. Immunohistochemistry (IHC) was used to assess GS expression in 260 liver tissue samples (from 120 HCC, 90 CHB stage 4, and 50 CHB stage 1–3 patients). Enzyme-linked immunosorbent assays of 325 samples (from 100 healthy donors, 33 CHB stage 1–3, 43 CHB stage 4, 111 HCC, and 45 extrahepatic diseases patients) were used to further analyze GS levels in serum. IHC studies showed the expression of GS in 70% of HCC patients, 46.7% of CHB stage 4 ... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4301179 Tue, 28 Dec 2010 15:15:24 +0100 4301179 Predictors of outcome in acute-on-chronic liver failure in children http://www.medworm.com/index.php?rid=4301180&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw5836k0005r7g8g8%2F Conclusion  The mortality in ACLF is 19.4% and the causes of death were multiorgan failure and liver failure. The SOFA score and INR were predictors of outcome of ACLF in children. Content Type Journal ArticleDOI 10.1007/s12072-010-9217-zAuthors Jeevan Lal, Pediatric Gastroenterology, Hepatology and Nutrition, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012 IndiaB. R. Thapa, Pediatric Gastroenterology, Hepatology and Nutrition, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012 IndiaPawan Rawal, Pediatric Gastroenterology, Hepatology and Nutrition, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012 IndiaR. K. Ratho, Department of Virology, Post Graduate Institute of Medical Education a... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4301180 Tue, 28 Dec 2010 15:15:21 +0100 4301180 Evolution and management of de novo neoplasm post-liver transplantation: a 20-year experience from a single European centre http://www.medworm.com/index.php?rid=4301181&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd2372741683t4k55%2F Conclusions  DN incidence has decreased in recent years; however, as survival post-LT increases, so does the incidence of DN. Surveillance programmes are necessary to diagnose DN at early stages. Content Type Journal ArticleDOI 10.1007/s12072-010-9231-1Authors Gonzalo Sapisochin, Department of Hepatobiliopancreatic Surgery and Transplantation, Hospital Universitario Vall D’Hebron, Universidad Autónoma de Barcelona, Barcelona, SpainItxarone Bilbao, Department of Hepatobiliopancreatic Surgery and Transplantation, Hospital Universitario Vall D’Hebron, Universidad Autónoma de Barcelona, Barcelona, SpainCristina Dopazo, Department of Hepatobiliopancreatic Surgery and Transplantation, Hospital Universitario Vall D’Hebron, Universidad Autónoma de Barcelona, Barcelon... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4301181 Tue, 28 Dec 2010 15:15:20 +0100 4301181 Superior long-term outcomes after surgery in child-pugh class a patients with single small hepatocellular carcinoma compared to radiofrequency ablation http://www.medworm.com/index.php?rid=4296878&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc8013v0r38r2x457%2F Conclusions  The long-term outcome after surgery for Child-Pugh class A and single small HCC is superior to that after RFA. Content Type Journal ArticleDOI 10.1007/s12072-010-9237-8Authors Won Kyoung Yun, Department of Medicine, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, KoreaMoon Seok Choi, Department of Medicine, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, KoreaDongil Choi, Department of Radiology, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, KoreaHyun-Chul Rhim, Department of Radiology, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, KoreaJae Won Joh, Department of Surgery, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, Ko... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4296878 Fri, 24 Dec 2010 07:02:25 +0100 4296878 Caffeoyl pyrrolidine derivative LY52 inhibits hepatocellular carcinoma invasion via suppressing matrix metalloproteinase-2 http://www.medworm.com/index.php?rid=4286173&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fhwluh46762055gg0%2F Conclusions  These results suggested that LY52 might inhibit the invasion of hepatocellular carcinoma cells by suppressing matrix metalloproteinase-2, although the inhibitory effects of LY52 on HBV-negative cells were more obvious than that of HBV-infected cells. Content Type Journal ArticleDOI 10.1007/s12072-010-9234-yAuthors Xin Zhao, Hepato-Biliary Surgery Division, The No.302 Hospital of PLA, Beijing, ChinaHuanli Xu, Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanYoshinori Inagaki, Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanNorihiro Kokudo, Hepato-Biliary-Pancreatic Surgery Division, Departm... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4286173 Mon, 20 Dec 2010 22:54:03 +0100 4286173 Eplerenone reverses spironolactone-induced painful gynaecomastia in cirrhotics http://www.medworm.com/index.php?rid=4286174&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F124659568024x414%2F Conclusion  In cirrhotic patients with painful gynaecomastia, the use of eplerenone instead of spironolactone might reverse pain and seems to be safe and clinically acceptable option. Content Type Journal ArticleDOI 10.1007/s12072-010-9235-xAuthors Georgios Dimitriadis, First Department of Internal Medicine, Democritus University of Thrace, GR-68100 Alexandroupolis, GreeceVasileios Papadopoulos, First Department of Internal Medicine, Democritus University of Thrace, GR-68100 Alexandroupolis, GreeceKonstantinos Mimidis, First Department of Internal Medicine, Democritus University of Thrace, GR-68100 Alexandroupolis, Greece Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=4286174 Mon, 20 Dec 2010 22:54:02 +0100 4286174 Hepatic vein waveforms in liver cirrhosis re-evaluated http://www.medworm.com/index.php?rid=4273204&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F03v3168883x82465%2F Conclusion  This study shows that the flat waveforms have no diagnostic value. Role of hepatic blood flow seems to be important suggesting hemodynamic changes rather than liver dysfunction as a plausible cause of change in waveforms. Content Type Journal ArticleDOI 10.1007/s12072-010-9226-yAuthors Sudhamshu K.C., National Academy of Medical Sciences, Kathmandu, NepalDilip Sharma, National Academy of Medical Sciences, Kathmandu, NepalSaroj Prasad Chataut, National Academy of Medical Sciences, Kathmandu, Nepal Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=4273204 Thu, 16 Dec 2010 06:54:55 +0100 4273204 Predictors for early HBeAg loss during lamivudine therapy in HBeAg-positive chronic hepatitis B patients with acute exacerbation http://www.medworm.com/index.php?rid=4268168&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2278v71443807h43%2F Conclusions  Female gender and baseline serum ALT level ≥1,000 IU/L were independent predictors of early HBeAg loss during lamivudine therapy in HBeAg-positive CHB patients with AE. Content Type Journal ArticleDOI 10.1007/s12072-010-9227-xAuthors Cheng-Yuan Peng, Division of Hepatogastroenterology, Department of Internal Medicine, China Medical University Hospital, No. 2, Yuh-Der Road, Taichung, 404 TaiwanChih-Bin Chen, Division of Hepatogastroenterology, Department of Internal Medicine, China Medical University Hospital, No. 2, Yuh-Der Road, Taichung, 404 TaiwanHsueh-Chou Lai, Division of Hepatogastroenterology, Department of Internal Medicine, China Medical University Hospital, No. 2, Yuh-Der Road, Taichung, 404 TaiwanWen-Pang Su, Division of Hepatogastroente... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4268168 Wed, 15 Dec 2010 20:47:57 +0100 4268168 Peroxisome proliferators-activated receptor γ2 Pro12Ala variant is associated with body mass index in non-alcoholic fatty liver disease patients http://www.medworm.com/index.php?rid=4226886&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj01037l361078802%2F Conclusions  Pro12Ala variation of the PPAR γ2 gene is associated with NAFLD and might play a role in the pathogenesis of NAFLD. Content Type Journal ArticleDOI 10.1007/s12072-010-9225-zAuthors A. C. Gupta, G.B. Pant Hospital, Institute of Genomics & Integrative Biology (IGIB), Jamia Millia Islamia University, Delhi, IndiaA. K. Chaudhory, Department of Gastroenterology, G.B. Pant Hospital, New Delhi, IndiaSukriti, Department of Gastroenterology, G.B. Pant Hospital, New Delhi, IndiaC. Pande, Department of Gastroenterology, G.B. Pant Hospital, New Delhi, IndiaP. Sakhuja, Department of Pathology, G.B. Pant Hospital, New Delhi, IndiaY. Singh, Allergy & Infectious diseases, Institute of Genomics & Integrative Biology (IGIB), Delhi, IndiaS. F. Basir, Department of Biosciences... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4226886 Tue, 30 Nov 2010 17:55:13 +0100 4226886 Erratum to: Efficacy and resistance of entecavir following 3 years of treatment of Japanese patients with lamivudine-refractory chronic hepatitis B http://www.medworm.com/index.php?rid=4141388&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F064766h245p05598%2F Erratum to: Efficacy and resistance of entecavir following 3 years of treatment of Japanese patients with lamivudine-refractory chronic hepatitis B Content Type Journal ArticleDOI 10.1007/s12072-010-9224-0Authors Yoshiyasu Karino, Department of Gastroenterology, Sapporo Kosei General Hospital, North 3, East 8, Chuo-ku, Sapporo, JapanJoji Toyota, Department of Gastroenterology, Sapporo Kosei General Hospital, North 3, East 8, Chuo-ku, Sapporo, JapanHiromitsu Kumada, Department of Hepatology, Toranomon Hospital, Tokyo, JapanYoshiaki Katano, Department of Gastroenterology, Graduate School of Medicine, Nagoya University, Aichi, JapanNamiki Izumi, Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, JapanHaruhiko Kobashi, Department of Gastroenterology and Hep... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4141388 Thu, 04 Nov 2010 17:51:21 +0100 4141388 Hemophagocytic syndrome occurring in an adult liver transplant recipient having Still’s disease http://www.medworm.com/index.php?rid=4111141&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6n6734638286j460%2F We present a 25-year-old man with a history of Still’s disease who presented with fever, arthralgia, and elevated serum ferritin levels 6 months after undergoing liver transplantation for fulminant hepatic failure due to autoimmune hepatitis potentially triggered by infliximab therapy. Liver biopsy demonstrated features consistent with hemophagocytic syndrome. The patient was successfully treated with a course of high dose steroids and had complete resolution of his symptoms and normalization of liver chemistry test abnormalities. Patients with Still’s disease may rarely complicate with fulminant hepatic failure with infliximab therapy. Hemophagocytic syndrome a rare potentially life threatening condition may occur in such patients following liver transplantation. Conte... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4111141 Sat, 23 Oct 2010 15:49:05 +0100 4111141 The role of lipopolysaccharide/toll-like receptor 4 signaling in chronic liver diseases http://www.medworm.com/index.php?rid=4090753&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F38712140883k60j7%2F Abstract  Toll-like receptor 4 (TLR4) is a pattern recognition receptor that functions as lipopolysaccharide (LPS) sensor and whose activation results in the production of several pro-inflammatory, antiviral, and anti-bacterial cytokines. TLR4 is expressed in several cells of healthy liver. Despite the constant confrontation of hepatic TLR4 with gut-derived LPS, the normal liver does not show signs of inflammation due to its low expression of TLR4 and ability to modulate TLR4 signaling. Nevertheless, there is accumulating evidence that altered LPS/TLR4 signaling is a key player in the pathogenesis of many chronic liver diseases (CLD). In this review, we first describe TLR4 structure, ligands, and signaling. Later, we review liver expression of TLR4 and discuss the role of L... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4090753 Wed, 20 Oct 2010 18:01:05 +0100 4090753 Spontaneous rupture of a giant hepatobiliary serous cystadenoma: report of a case and literature review http://www.medworm.com/index.php?rid=4069295&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw843l78437433377%2F We report a case of hepatobiliary serous cystadenoma with mesenchymal stroma, initially misdiagnosed as simple hepatic cyst with intracystic hemorrhage. The rapid growth of the giant tumor leads to spontaneous rupture, almost turned into a life-threatening event. After emergency formal liver resection, the patient recovered well without recurrence during the 6-month follow-up period. We also reviewed the literature, proposed possible factors for the tumor’s rapid growth, and discuss the current diagnostic and treatment modalities. Content Type Journal ArticleDOI 10.1007/s12072-010-9221-3Authors Yongliang Sun, Department of Liver Surgery, Peking Union Medical College (PUMC) Hospital, 1# Shuaifuyuan, Dongcheng District, Beijing, 100730 ChinaXin Lu, Department of Liver Surgery, P... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4069295 Tue, 12 Oct 2010 05:59:50 +0100 4069295 Giant cystic lymphangioma of the liver http://www.medworm.com/index.php?rid=4062648&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fyp11522257143665%2F Conclusion  Surgical resection is an effective therapy in treating giant cystic lymphangioma. Content Type Journal ArticleDOI 10.1007/s12072-010-9220-4Authors Liang Huang, First Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, #225 Changhai Road, Shanghai, 200438 People’s Republic of ChinaJing Li, First Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, #225 Changhai Road, Shanghai, 200438 People’s Republic of ChinaFeiguo Zhou, First Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, #225 Changhai Road, Shanghai, 200438 People’s Republic of ChinaJianjun Yan, First Department of Hepatic Surgery, Eas... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4062648 Sat, 09 Oct 2010 16:51:22 +0100 4062648 Study of adiponectin in chronic liver disease and cholestasis http://www.medworm.com/index.php?rid=4062649&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk911552816k65104%2F Conclusions  Adiponectin is elevated in cirrhosis and shows correlation with degree of hepatocellular injury and cholestasis. Finally, adiponectin levels in cirrhosis do not correlate with parameters of body composition or metabolism but exclusively with reduced liver function. Content Type Journal ArticleDOI 10.1007/s12072-010-9216-0Authors Tary A. Salman, Hepatology, National Liver Institute, Menofeya University, Shebeen El-Kom, Menoufiya EgyptNaglaa Allam, Hepatology, National Liver Institute, Menofeya University, Shebeen El-Kom, Menoufiya EgyptGasser I. Azab, Hepatology, National Liver Institute, Menofeya University, Shebeen El-Kom, Menoufiya EgyptAhmed A. Shaarawy, Clinical Pathology, National Liver Institute, Menofeya University, Shebeen El-Kom, Menoufiya Egypt... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4062649 Sat, 09 Oct 2010 05:59:51 +0100 4062649 Sclerosing cholangitis associated with retroperitoneal fibrosis: a case of multisystem fibroinflammatory disorder http://www.medworm.com/index.php?rid=4051941&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F41rxq5020511g32n%2F Conclusion  The diagnosis of IgG4-related sclerosing disease should always be taken into consideration in patients with sclerosing cholangitis, especially when it is associated with any fibroinflammatory disorder. Content Type Journal ArticleDOI 10.1007/s12072-010-9222-2Authors Grazyna T. Rompa, Department of Gastroenterology and Hepatology, Medical University of Gdansk, ul. Debinki 7, 80-211 Gdansk, PolandAnna K. Jablonska, Department of Gastroenterology and Hepatology, Medical University of Gdansk, ul. Debinki 7, 80-211 Gdansk, PolandMarek T. Guzek, Department of Gastroenterology and Hepatology, Medical University of Gdansk, ul. Debinki 7, 80-211 Gdansk, PolandMichal M. Dubowik, Department of Gastroenterology and Hepatology, Medical University of Gdansk, ul. Debinki... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4051941 Thu, 07 Oct 2010 05:47:49 +0100 4051941 Liver stiffness measurement in the risk assessment of hepatocellular carcinoma for patients with chronic hepatitis http://www.medworm.com/index.php?rid=4051942&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb804675812626n13%2F Conclusions  LSM identified the risk group for HCC presence in chronic hepatitis patients and had high specificity in the prediction of HCC with the cut-off of 24 kPa. Content Type Journal ArticleDOI 10.1007/s12072-010-9223-1Authors Yuan-Hung Kuo, Division of Hepato-Gastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Rd, Niao-Sung, Kaohsiung, 833 TaiwanSheng-Nan Lu, Division of Hepato-Gastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Rd, Niao-Sung, Kaohsiung, 833 TaiwanChao-Hung Hung, Division of Hepato-Gastroenterology, Department of Internal Medic... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4051942 Thu, 07 Oct 2010 05:47:48 +0100 4051942 Long-term interferon therapy after radiofrequency ablation is effective in treating patients with HCV-associated hepatocellular carcinoma http://www.medworm.com/index.php?rid=4002160&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn78m5jlx827r2133%2F Conclusion  These results show the importance of maintaining the liver function and suggest that long-term IFN administration after RFA inhibits recurrence and contributes to an improved outcome in patients (in particular, IFN responders) who initially develop HCC. Content Type Journal ArticleDOI 10.1007/s12072-010-9214-2Authors Soji Shimomura, Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663-8501 JapanNaoto Ikeda, Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663-8501 JapanMasaki Saito, Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medi... Hepatology International journals http://www.medworm.com/rss/comments.php?id=4002160 Fri, 24 Sep 2010 05:49:01 +0100 4002160 Fibrosis and AST to platelet ratio index predict post-operative prognosis for solitary small hepatitis B-related hepatocellular carcinoma http://www.medworm.com/index.php?rid=3999833&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F402r5v3453284021%2F Conclusions  For patients with solitary small HBV-related HCC who underwent resection, minimal fibrosis is associated with a lower incidence of recurrence and with better survival. APRI could serve as a reliable marker for assessing hepatic fibrosis and predicting survival. Content Type Journal ArticleDOI 10.1007/s12072-010-9213-3Authors Hung-Hsu Hung, Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, TaiwanChien-Wei Su, Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, TaiwanChiung-Ru Lai, Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, TaiwanGar-Yang Chau, Department of Medicine, Institute of Clinical Medicine, School of Medicine, N... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3999833 Thu, 23 Sep 2010 17:00:46 +0100 3999833 Erratum to: Occult hepatitis B in blood donors in Indonesia: altered antigenicity of the hepatitis B virus surface protein http://www.medworm.com/index.php?rid=3995866&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr525384l4232lxx8%2F Content Type Journal ArticleDOI 10.1007/s12072-010-9212-4Authors Meta D. Thedja, Eijkman Institute for Molecular Biology, Jl. Diponegoro 69, Jakarta, IndonesiaMartono Roni, Eijkman Institute for Molecular Biology, Jl. Diponegoro 69, Jakarta, IndonesiaAlida R. Harahap, Eijkman Institute for Molecular Biology, Jl. Diponegoro 69, Jakarta, IndonesiaNurjati C. Siregar, Eijkman Institute for Molecular Biology, Jl. Diponegoro 69, Jakarta, IndonesiaSusan I. Ie, Eijkman Institute for Molecular Biology, Jl. Diponegoro 69, Jakarta, IndonesiaDavid H. Muljono, Eijkman Institute for Molecular Biology, Jl. Diponegoro 69, Jakarta, Indonesia Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=3995866 Wed, 22 Sep 2010 05:53:41 +0100 3995866 Radiofrequency ablation of small hepatocellular carcinoma with intravenous pegylated liposomal doxorubicin http://www.medworm.com/index.php?rid=3981596&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7w032x1662661717%2F Conclusion  Intravenous PLD before RFA reduced contraction of ablative volume and might have no impact on tumor progression and survival in patients with small HCC after RFA. Content Type Journal ArticleDOI 10.1007/s12072-010-9215-1Authors Jing-Houng Wang, Division of Hepato-Gastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Rd, Niaosung 833, Kaohsiung, TaiwanHung-Da Tung, Department of Gastroenterology, Chi Mei Foundation Hospital, Liouying, Tainan, TaiwanTai-Yi Chen, Department of Radiology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, TaiwanChao-Hung Hung, Division of Hepato-Gastroenterology, De... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3981596 Fri, 17 Sep 2010 06:51:30 +0100 3981596 Brush border enzymes and absorptive capacity in extrahepatic portal venous obstruction in children http://www.medworm.com/index.php?rid=3948484&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp14x712m22858x5v%2F Conclusion  EHPVO leads to decrease in levels of brush border enzymes in small bowel but their absorption capacity remains normal. Content Type Journal ArticleDOI 10.1007/s12072-010-9211-5Authors Gurbakhshish Singh Sidhu, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Gastroenterology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012 IndiaB. R. Thapa, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Gastroenterology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012 IndiaPawan Rawal, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Gastroenterology, Post Graduate Institute of Medical Education and Resear... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3948484 Tue, 07 Sep 2010 17:24:22 +0100 3948484 New antiviral therapies for chronic hepatitis C http://www.medworm.com/index.php?rid=3883162&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fyr52kn0l13570240%2F Abstract  Chronic hepatitis C is an important health issue worldwide. The current standard therapy is based on a combination of pegylated-interferon (pegIFN) and ribavirin (RBV), but this treatment leads to only ~50% sustained virological response (SVR) in patients with HCV genotype 1 and high viral loads, who were mostly null-responders or relapsers. Among HCV genotypes other than HCV genotype 1, especially HCV genotype 4 patients show only 40–70% SVR by this treatment. Although new drugs also depend on the combination of pegIFN and RBV, it appears that these drugs improve not only rapid virological response (RVR) but also early virological response, leading to SVR in these patients. In the near future, we predict higher SVR rates in chronic hepatitis C patients treated ... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3883162 Wed, 18 Aug 2010 06:49:34 +0100 3883162 Epidemiologic risk factors of hepatocellular carcinoma in a rural region of Egypt http://www.medworm.com/index.php?rid=3883161&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0q252t48634uv4n7%2F Conclusion  Occupational exposure may play an important role in the development of HCC. Farming, industrial exposures and cigarette smoking may increase the risk of HCC among HCV-seropositive individuals. Future research focusing on mechanisms of occupational exposures among HCV patients in this population is needed. Content Type Journal ArticleDOI 10.1007/s12072-010-9187-1Authors Amr S. Soliman, Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI USAChu-Wei Hung, Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI USAAlexander Tsodikov, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI USAIbrahim A. Seifeldin, Tanta Cancer Center, Tanta, Gharbiah Egyp... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3883161 Wed, 18 Aug 2010 06:49:34 +0100 3883161 Fluidized-bed bioartificial liver assist devices (BLADs) based on microencapsulated primary porcine hepatocytes have risk of porcine endogenous retroviruses transmission http://www.medworm.com/index.php?rid=3874209&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc62373q2055u5gm5%2F Conclusion  The kind of fluidized-bed BLADs based on microencapsulated primary porcine hepatocytes have risk of PERVs transmission. Further extensive pre-clinical study focused on biosafety is warranted. Content Type Journal ArticleDOI 10.1007/s12072-010-9210-6Authors Qian Yang, The First Affiliated Hospital, College of Medicine, Zhejiang University, No.79 Qingchun Road, Hangzhou, 310003 ChinaFei Liu, The First Affiliated Hospital, College of Medicine, Zhejiang University, No.79 Qingchun Road, Hangzhou, 310003 ChinaXiao Ping Pan, The First Affiliated Hospital, College of Medicine, Zhejiang University, No.79 Qingchun Road, Hangzhou, 310003 ChinaGuoLiang Lv, The First Affiliated Hospital, College of Medicine, Zhejiang University, No.79 Qingchun Road, Hangzhou, 310003 Ch... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3874209 Sat, 14 Aug 2010 16:46:17 +0100 3874209 Effects of nuclear receptor FXR on the regulation of liver lipid metabolism in patients with non-alcoholic fatty liver disease http://www.medworm.com/index.php?rid=3866117&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F944127l2415p56u6%2F Conclusion  Our data showed that the decreased expression of hepatic FXR is associated with an increased expression of LXR, SREBP-1C, and hepatic triglyceride synthesis; furthermore, increased SREBP-1C is associated with the degree of hepatic steatosis in the NAFLD patients. Content Type Journal ArticleDOI 10.1007/s12072-010-9202-6Authors Zhao-Xia Yang, Department of Gastroenterology and Hepatology, The Second Affiliated Hospital Chongqing Medical University, Chongqing, ChinaWei Shen, Department of Gastroenterology and Hepatology, The Second Affiliated Hospital Chongqing Medical University, Chongqing, ChinaHang Sun, Institute for Viral Hepatitis of Chongqing Medical University, Chongqing Medical University, Chongqing, China Journal Hepatology InternationalOnli... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3866117 Thu, 12 Aug 2010 06:04:16 +0100 3866117 Comparison of adverse effects related to pegylated interferon-based therapy for patients with chronic hepatitis B and chronic hepatitis C in Taiwan http://www.medworm.com/index.php?rid=3860066&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F305285t6w61130n1%2F Conclusions  Patients with CHB treated with Peg-IFN had fewer AEs than patients with CHC treated with Peg-IFN/ribavirin. All patients were treated safely. Content Type Journal ArticleDOI 10.1007/s12072-010-9208-0Authors Jeng-Fu Yang, Department of Preventive Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanYi-Hui Kao, School of Post-Baccalaureate Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanChia-Yen Dai, Division of Hepatobiliary and Pancreatic Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanJee-Fu Huang, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanMing-Yen Hsieh, Division of Hepatobiliary and Pa... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3860066 Sun, 08 Aug 2010 17:04:03 +0100 3860066 Superior response to pegylated interferon and ribavirin in Asians with chronic hepatitis C http://www.medworm.com/index.php?rid=3860067&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc1k308551kr22545%2F Conclusion  Asian (Non-South) race is a strong independent predictor of SVR. Content Type Journal ArticleDOI 10.1007/s12072-010-9207-1Authors Venessa Pattullo, Division of Medicine, University Health Network, Toronto Western Hospital, Toronto, ON CanadaE. Jenny Heathcote, Division of Medicine, University Health Network, Toronto Western Hospital, Toronto, ON CanadaDavid K. H. Wong, Division of Medicine, University Health Network, Toronto Western Hospital, Toronto, ON Canada Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International) Hepatology International journals http://www.medworm.com/rss/comments.php?id=3860067 Sat, 07 Aug 2010 16:49:43 +0100 3860067 Rebleeding rates following TIPS for variceal hemorrhage in the Viatorr era: TIPS alone versus TIPS with variceal embolization http://www.medworm.com/index.php?rid=3832560&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F235g138j65772543%2F Conclusions  TIPS alone showed a high incidence of rebleeding in this series, whereas TIPS with variceal embolization resulted in reduced recurrent hemorrhage. The efficacy of embolization during TIPS performed for variceal hemorrhage versus TIPS alone should be further compared with larger prospective randomized trials. Content Type Journal ArticleDOI 10.1007/s12072-010-9206-2Authors Ron C. Gaba, Interventional Radiology Section, Department of Radiology, University of Illinois Medical Center at Chicago, 1740 West Taylor Street, MC 931, Chicago, IL 60612, USAJames T. Bui, Interventional Radiology Section, Department of Radiology, University of Illinois Medical Center at Chicago, 1740 West Taylor Street, MC 931, Chicago, IL 60612, USAScott J. Cotler, Hepatology Sectio... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3832560 Fri, 06 Aug 2010 07:14:17 +0100 3832560 Non-invasive assessment of changes in liver fibrosis via liver stiffness measurement in patients with chronic hepatitis B: impact of antiviral treatment on fibrosis regression http://www.medworm.com/index.php?rid=3825194&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy4h106024t217873%2F Conclusions  Our preliminary data suggest that LSM can be used to assess liver fibrosis regression after antiviral treatment using nucleos(t)ide analogs in patients with CHB. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-010-9201-7Authors Seung Up Kim, Yonsei University College of Medicine Department of Internal Medicine Seoul KoreaJun Yong Park, Yonsei University College of Medicine Department of Internal Medicine Seoul KoreaDo Young Kim, Yonsei University College of Medicine Department of Internal Medicine Seoul KoreaSang Hoon Ahn, Yonsei University College of Medicine Department of Internal Medicine Seoul KoreaEun Hee Choi, Yonsei University College of Medicine Department of Biostatistics Seoul KoreaJae Yeon Seok, Yonsei University College... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3825194 Wed, 04 Aug 2010 08:06:31 +0100 3825194 Serum hs-CRP was correlated with treatment response to pegylated interferon and ribavirin combination therapy in chronic hepatitis C patients http://www.medworm.com/index.php?rid=3825195&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp2l056632512x27m%2F Conclusion  CHC patients had a higher hs-CRP level than healthy controls which could be ameliorated after peginterferon/ribavirin combination therapy. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-010-9200-8Authors Chung-Feng Huang, Kaohsiung Medical University Hospital Hepatobiliary Division, Department of Internal Medicine Kaohsiung TaiwanMing-Yen Hsieh, Kaohsiung Medical University Hospital Hepatobiliary Division, Department of Internal Medicine Kaohsiung TaiwanJeng-Fu Yang, Kaohsiung Medical University Hospital Hepatobiliary Division, Department of Internal Medicine Kaohsiung TaiwanWu-Cheng Chen, Kaohsiung Medical University Hospital Department of Preventive Medicine, Kaohsiung Municipal Ta-Tong Hospital Kaohsiung TaiwanMing-Lun Yeh, Kaoh... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3825195 Wed, 04 Aug 2010 08:06:30 +0100 3825195 Adult Langerhans cell histiocytosis and sclerosing cholangitis: a case report and review of the literature http://www.medworm.com/index.php?rid=3818720&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe4383t8075603522%2F Conclusion  Sclerosing cholangitis caused by Langerhans cell histiocytosis is a rare condition in the adult population, but it has a high mortality. There is no definitive therapy other than liver transplantation. The long-term efficacy of liver transplantation remains unknown. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s12072-010-9205-3Authors Ibrahim Hatemi, Istanbul University Cerrahpasa Medical Faculty Division of Gastroenterology, Department of Internal Medicine 34098 Aksaray, Istanbul TurkeyBirol Baysal, Istanbul University Cerrahpasa Medical Faculty Division of Gastroenterology, Department of Internal Medicine 34098 Aksaray, Istanbul TurkeyHakan Senturk, Istanbul University Cerrahpasa Medical Faculty Division of Gastroenterology, Department of... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3818720 Tue, 03 Aug 2010 17:28:24 +0100 3818720 Occult hepatitis B in blood donors in Indonesia: altered antigenicity of the hepatitis B virus surface protein http://www.medworm.com/index.php?rid=3818721&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fdk437u56h448598g%2F Conclusions  OBI was detected in blood donors’ samples in Indonesia. Anti-HBc was shown to be a better screening parameter than HBsAg, however, it might result in the loss of donors particularly in endemic countries. HBsAg detection failure in this study might be due to mutations altering the protein antigenicity and/or the low-level carriage of HBV. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-010-9203-5Authors Meta D. Thedja, Eijkman Institute for Molecular Biology Jl. Diponegoro 69 Jakarta IndonesiaMartono Roni, Eijkman Institute for Molecular Biology Jl. Diponegoro 69 Jakarta IndonesiaAlida R. Harahap, Eijkman Institute for Molecular Biology Jl. Diponegoro 69 Jakarta IndonesiaNurjati C. Siregar, Eijkman Institute for Molecular Biology... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3818721 Tue, 03 Aug 2010 15:01:21 +0100 3818721 Hepatitis B virus genotyping by enzyme-linked immunosorbent assay in Taiwan http://www.medworm.com/index.php?rid=3818722&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F57m7p7m3140k031t%2F Conclusions  ELISA is a practical and a useful method for HBV genotyping in a clinical setting in Taiwan, in particular for patients with lower levels of HBV DNA. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-010-9198-yAuthors Shu-Fen Liu, Kaohsiung Medical University Hospital Hepatobiliary Division, Department of Internal Medicine Kaohsiung TaiwanMeng-Hsuan Hsieh, Kaohsiung Municipal HsiaoKang Hospital Department of Occupational Medicine Kaohsiung TaiwanNai-Jen Hou, Kaohsiung Municipal HsiaoKang Hospital Department of Internal Medicine Kaohsiung TaiwanMing-Yen Hsieh, Kaohsiung Medical University Faculty of Internal Medicine, College of Medicine Kaohsiung TaiwanJee-Fu Huang, Kaohsiung Municipal HsiaoKang Hospital Department of Internal Medici... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3818722 Tue, 03 Aug 2010 15:01:20 +0100 3818722 Comparison of effects of hepatitis E or A viral superinfection in patients with chronic hepatitis B http://www.medworm.com/index.php?rid=3818723&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv17776x6w10g166g%2F Conclusions  The comparison of clinical outcomes revealed that patients with HBV + HEV had more advanced baseline liver disease and a poorer prognosis than those with HBV + HAV. Because there is no vaccine against HEV, patients with CHB should take appropriate precautions against superinfection with HEV, such as consumption of boiled water and well-cooked food, in regions where it is endemic. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-010-9204-4Authors Xiaohong Zhang, Third Affiliated Hospital of Sun Yat-Sen University Department of Infectious Diseases Shipai Guangzhou 510630 People’s Republic of ChinaWeimin Ke, Third Affiliated Hospital of Sun Yat-Sen University Department of Infectious Diseases Shipai Guangzhou 510... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3818723 Mon, 02 Aug 2010 19:24:03 +0100 3818723 A case–control study on sequence variations in the enhancer II/core promoter/precore and X genes of hepatitis B virus in patients with hepatocellular carcinoma http://www.medworm.com/index.php?rid=3818724&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc0q0251350183650%2F Conclusion  These data suggested that A1762T/G1764A and G1899A mutations were associated with the development of HCC in Thai patients. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-010-9197-zAuthors Pisit Tangkijvanich, Chulalongkorn University Department of Biochemistry, Faculty of Medicine Bangkok 10330 ThailandPattaratida Sa-nguanmoo, Chulalongkorn University Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine Bangkok 10330 ThailandVarocha Mahachai, Chulalongkorn University Department of Medicine, Faculty of Medicine Bangkok 10330 ThailandApiradee Theamboonlers, Chulalongkorn University Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine Bangkok 10330 ThailandYong Poovo... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3818724 Mon, 02 Aug 2010 19:24:02 +0100 3818724 Spontaneous regression of a solitary necrotic nodule of the liver http://www.medworm.com/index.php?rid=3806891&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F501346v26j75q543%2F We present the case of an incidentally detected hepatic mass (diameter 2 cm) in a 35-year-old man. The hepatic mass was diagnosed as a solitary necrotic nodule by liver biopsy. Follow-up radiologic examination revealed that the solitary necrotic nodule had spontaneously regressed. This is the first report on the natural course history of a solitary necrotic nodule. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s12072-010-9199-xAuthors Chang Soo Choi, Wonkwang University Hospital Department of Internal Medicine, College of Medicine Iksan KoreaEun Young Cho, Wonkwang University Hospital Department of Internal Medicine, College of Medicine Iksan KoreaJin Soo Jeong, Wonkwang University Hospital Department of Internal Medicine, College of Medicine Iksan KoreaChong J... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3806891 Thu, 29 Jul 2010 16:08:06 +0100 3806891 Angiogenesis: multiple masks in hepatocellular carcinoma and liver regeneration http://www.medworm.com/index.php?rid=3806892&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl417m24728482636%2F Abstract  Hepatocellular carcinoma (HCC) is naturally resistant to radiotherapy and cytotoxic chemotherapy, leaving surgery as the mainstream therapeutic approach. However, the 5-year recurrence rate after curative resection is as high as 61.5%. The background hepatitis B- or C-induced cirrhosis and the presence of micrometastases at the time of surgery have been regarded as two main causes of recurrence. Recently, accumulating evidence suggests that growth factors and cytokines released during the physiological process of post-surgical liver regeneration could induce the activation of dormant micrometastatic lesions. The establishment of neovasculature to support either liver regeneration or HCC growth involves multiple cell types including liver sinusoidal endothelial cel... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3806892 Thu, 29 Jul 2010 16:08:04 +0100 3806892 Long-term efficacy of nucleoside monotherapy in preventing HBV infection in HBsAg-negative recipients of anti-HBc-positive donor livers http://www.medworm.com/index.php?rid=3800365&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft112g7w82k77v580%2F Conclusions  Nucleoside monotherapy is sufficient in preventing HBV infection in HBsAg-negative recipients of anti-HBc-positive donor livers. HBV prophylaxis is necessary in anti-HBs-positive recipients of anti-HBc-positive donor livers. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-010-9188-0Authors Watcharasak Chotiyaputta, University of Michigan Health System Division of Gastroenterology, Department of Internal Medicine Ann Arbor MI USAShawn J. Pelletier, University of Michigan Health System Division of Transplantation, Department of Surgery Ann Arbor MI USARobert J. Fontana, University of Michigan Health System Division of Gastroenterology, Department of Internal Medicine Ann Arbor MI USAAnna S. F. Lok, University of Michigan Health Syste... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3800365 Wed, 28 Jul 2010 17:45:48 +0100 3800365 Opposite effects of high and low doses of interleukin-2 on T cell-mediated hepatitis in mice (interleukin-2 on hepatitis) http://www.medworm.com/index.php?rid=3800366&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa17307x5142x8806%2F Conclusion  Various strategies of rhIL-2 administration play different roles in Con A-induced hepatitis, suggesting the importance of IL-2 administrative regime in clinical liver diseases. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-010-9196-0Authors Xiaoang Zhang, University of Science and Technology of China Institute of Immunology, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences Hefei Anhui 230027 ChinaHua-Xing Wei, University of Science and Technology of China Institute of Immunology, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences Hefei Anhui 230027 ChinaSun Rui, University of Science and Technology of China Institute of Immunology, Hefei National Labor... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3800366 Wed, 28 Jul 2010 17:45:47 +0100 3800366 A pilot trial of high-dose ursodeoxycholic acid in nonalcoholic steatohepatitis http://www.medworm.com/index.php?rid=3800367&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh767828x0n2584j1%2F Conclusion  High-dose UCDA does not normalize aminotransaminase levels in patients with NASH. Other inexpensive well-tolerated agents for the treatment of NASH need to be investigated. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-010-9195-1Authors Leon A. Adams, University of Western Australia School of Medicine and Pharmacology, Sir Charles Gairdner Hospital Perth AustraliaPaul Angulo, Mayo Clinic Department of Gastroenterology and Hepatology Rochester USAJan Petz, Mayo Clinic Department of Gastroenterology and Hepatology Rochester USAJill Keach, Mayo Clinic Department of Gastroenterology and Hepatology Rochester USAKeith D. Lindor, Mayo Clinic Department of Gastroenterology and Hepatology Rochester USA Journal Hepatology Internation... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3800367 Tue, 27 Jul 2010 19:46:51 +0100 3800367 Disturbances of parathyroid hormone–vitamin D axis in non-cholestatic chronic liver disease: a cross-sectional study http://www.medworm.com/index.php?rid=3792146&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4232878177788034%2F Conclusions  Vitamin D inadequacy and the severity of liver dysfunction move in parallel in patients with non-cholestatic CLD. Vitamin D assessment and replacement should be considered in the management of patients with non-cholestatic CLD. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-010-9194-2Authors Arash Miroliaee, Tehran University of Medical Sciences Department of Gastroenterology, Imam Hospital Tehran IranMohsen Nasiri-Toosi, Tehran University of Medical Sciences Department of Gastroenterology, Imam Hospital Tehran IranOmid Khalilzadeh, Tehran University of Medical Sciences Department of Gastroenterology, Imam Hospital Tehran IranAlireza Esteghamati, Tehran University of Medical Sciences Endocrinology and Metabolism Research Center (E... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3792146 Sun, 25 Jul 2010 06:55:22 +0100 3792146 Outcome of small liver nodules detected by computed tomographic angiography in patients with hepatocellular carcinoma http://www.medworm.com/index.php?rid=3792147&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr6455154l47758k7%2F Conclusions  These findings indicate that CTAP and CTHA are recommended for determining the stage of HCC, especially when the HCC nodule is larger than 30 mm in diameter. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-010-9190-6Authors Hideki Ohnishi, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Department of Gastroenterology and Hepatology 2-5-1 Shikata-cho Okayama Okayama 700-8558 JapanKohsaku Sakaguchi, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Department of Gastroenterology and Hepatology 2-5-1 Shikata-cho Okayama Okayama 700-8558 JapanKazuhiro Nouso, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Department of G... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3792147 Sat, 24 Jul 2010 20:06:36 +0100 3792147 Usefulness of multi-detector helical CT with multiplanar reconstruction for depicting the duodenal varices with multiple collateral shunt vessels http://www.medworm.com/index.php?rid=3792148&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm4156173qp04310v%2F We report the case of a 58-year-old man with liver cirrhosis with repeated bleeding from duodenal varices. Esophagogastroduodenoscopy (EGD) revealed multinodular varices in the third portion of the duodenum. Then we conducted a capsule endoscopy (CE) and found fresh blood in the duodenum, suggesting duodenal variceal hemorrhage. Angiography depicted the varices with one afferent and two efferent vessels. Abdominal CT examination was conducted using a four-channel multi-detector row CT scanner. The multiplanar reconstructed images revealed not only the varices, but also three afferent and two efferent vessels. The patient was treated by surgical ligation and sclerotherapy, because of its complicated porto-systemic shunt and reserved liver function. No gastrointestinal bleeding has bee... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3792148 Sat, 24 Jul 2010 13:51:54 +0100 3792148 Reduction of liver stiffness following resolution of acute flares of chronic hepatitis B http://www.medworm.com/index.php?rid=3792149&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd765654178tv3p77%2F Conclusion  Liver stiffness was increased in patients with severe hepatitis B flares, with return to near normal levels by 6 months. Transient elastography for proper assessment of liver fibrosis should be performed at least 6 months after flare. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-010-9189-zAuthors James Fung, The University of Hong Kong Department of Medicine, Queen Mary Hospital Hong Kong SAR ChinaChing-Lung Lai, The University of Hong Kong Department of Medicine, Queen Mary Hospital Hong Kong SAR ChinaDavid But, The University of Hong Kong Department of Medicine, Queen Mary Hospital Hong Kong SAR ChinaAxel Hsu, The University of Hong Kong Department of Medicine, Queen Mary Hospital Hong Kong SAR ChinaWai-Kay Seto, The ... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3792149 Sat, 24 Jul 2010 13:51:53 +0100 3792149 Clinical utility of prothrombin induced by vitamin K absence in the detection of hepatocellular carcinoma in Indian population http://www.medworm.com/index.php?rid=3755809&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv5532jw2067724r4%2F Conclusion  PIVKA-II was more sensitive and specific than AFP for diagnosing HCC in the Indian population. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-010-9186-2Authors Balkrishan Sharma, Postgraduate Institute of Medical Education and Research Department of Hepatology Chandigarh IndiaRadhika Srinivasan, Postgraduate Institute of Medical Education and Research Department of Cytopathology Chandigarh IndiaYogesh Kumar Chawla, Postgraduate Institute of Medical Education and Research Department of Hepatology Chandigarh IndiaShweta Kapil, Postgraduate Institute of Medical Education and Research Department of Hepatology Chandigarh IndiaNitin Saini, Postgraduate Institute of Medical Education and Research Department of Hepatology Chandigarh IndiaBhup... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3755809 Tue, 13 Jul 2010 15:28:11 +0100 3755809 Evaluation of long-term entecavir treatment in stable chronic hepatitis B patients switched from lamivudine therapy http://www.medworm.com/index.php?rid=3741715&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn2843373h7436140%2F Conclusions  Switching lamivudine-treated patients with chronic hepatitis B to entecavir results in increased virologic suppression with no evidence of resistance through 2 years of entecavir therapy. These findings support recommendations in the current Japanese treatment guidelines that stable lamivudine patients should be switched to entecavir. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-010-9185-3Authors Tatsuya Ide, Kurume University School of Medicine Division of Gastroenterology, Department of Medicine Fukuoka JapanMichio Sata, Kurume University School of Medicine Division of Gastroenterology, Department of Medicine Fukuoka JapanKazuaki Chayama, Hiroshima University Department of Medicine and Molecular Science, Graduate School ... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3741715 Thu, 08 Jul 2010 12:09:15 +0100 3741715 Increased incidence of gastroesophageal reflux disease in patients with chronic hepatitis B virus infection http://www.medworm.com/index.php?rid=3716020&cid=s_35967_20_f&fid=35967&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm700352p42q7x056%2F Conclusions  Our findings indicate a close association between chronic HBV infection and GERD, especially in female subjects and those with higher APRI levels. Moreover, HBV carriers with higher AST or TG levels have higher incidence of erosive esophagitis. The interactions between chronic HBV infection and GERD need further studies. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-010-9184-4Authors Ching-Sheng Hsu, Buddhist Tzu Chi General Hospital Division of Gastroenterology, Department of Internal Medicine Taipei TaiwanChia-Chi Wang, Buddhist Tzu Chi General Hospital Division of Gastroenterology, Department of Internal Medicine Taipei TaiwanPin-Chao Wang, Buddhist Tzu Chi General Hospital Division of Gastroenterology, Department of Internal... Hepatology International journals http://www.medworm.com/rss/comments.php?id=3716020 Wed, 30 Jun 2010 15:23:12 +0100 3716020