MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Hepatology Research' source. Thu, 09 Feb 2012 09:15:08 +0100 http://www.medworm.com/index.php?rid=5667281&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2012.00973.x Conclusions:  High TXN levels in MHCC97H cells protect them from DNA damage and cellular senescence under hypoxia. Targeting TXN might enhance the chemotherapeutic effects of some DNA‐damaging agents against hepatocellular carcinoma. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5667281 Thu, 02 Feb 2012 05:00:00 +0100 5667281 http://www.medworm.com/index.php?rid=5667280&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2012.00976.x Conclusions:  Plasma fCh levels are closely related to the grade of liver steatosis and fibrosis, and predict NASH severity. Plasma fCh levels are therefore a potential diagnostic marker for early‐stage NASH in clinical practice. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5667280 Thu, 02 Feb 2012 05:00:00 +0100 5667280 http://www.medworm.com/index.php?rid=5667279&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2012.00977.x Conclusion:  Our results suggest that the genetic alteration at EphA3 locus plays a part role in the occurrence of chronic severe hepatitis B. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5667279 Thu, 02 Feb 2012 05:00:00 +0100 5667279 http://www.medworm.com/index.php?rid=5667278&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2012.00978.x AbstractRecent advance in the technologies of both molecular biology and regenerative medicine has made it possible to identify bone marrow (BM)‐derived cells migrating into various fibrotic organs including the liver. A number of studies have reported that BM‐derived cells migrating into fibrotic liver tissue exhibit a myofibroblast‐like phenotype and may participate in the progression of liver fibrosis. On the other hand, it has also been shown that BM‐derived cells express matrix metalloproteinases and contribute to the regression of experimental liver fibrosis. These contradictory results may arise, at least in part, from the uncertainty of various different methods that have been employed in those studies. In this review article, we describe the interplay between BM and liver ... Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5667278 Wed, 01 Feb 2012 05:00:00 +0100 5667278 http://www.medworm.com/index.php?rid=5649088&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00932.x Conclusions:  JNK activity in non‐cancerous liver tissue is considered as a reliable predictive biomarker for post‐operative recurrence in HCC. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5649088 Wed, 01 Feb 2012 05:00:00 +0100 5649088 http://www.medworm.com/index.php?rid=5649087&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00952.x Conclusions:  Hepatectomy for HCC was a feasible option even in super elderly patients aged 80 years or older with accurate selection. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5649087 Wed, 01 Feb 2012 05:00:00 +0100 5649087 http://www.medworm.com/index.php?rid=5617143&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00913.x A 22‐year‐old Japanese woman was found to have severe esophageal varices and then suffered from hepatic encephalopathy. She was diagnosed with Budd‐Chiari syndrome (BCS) due to hepatic vein (HV) thrombosis accompanied by portal vein thrombosis without inferior vena cava (IVC) obstruction. Latent myeloproliferative neoplasm (MPN) lacking the JAK2‐V617F mutation was considered to be the underlying disease. Liver transplantation was strikingly effective for treating the clinical symptoms attributable to portal hypertension. Although thrombosis of the internal jugular vein occurred due to thrombocythemia, which manifested after transplantation despite anticoagulation therapy with warfarin, the thrombus immediately disappeared with the addition of aspirin. Neither thrombosis nor BCS has... Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5617143 Sat, 21 Jan 2012 22:48:33 +0100 5617143 http://www.medworm.com/index.php?rid=5617139&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2012.00969.x Conclusions:  LES with BCAA supplementation significantly and rapidly improves liver functioning and CPS in LC patients who have undergone RFA for HCC. Control of blood‐sugar levels is necessary when calorie‐containing BCAA is administered to LC patients with impaired glucose tolerance. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5617139 Sat, 21 Jan 2012 22:48:04 +0100 5617139 http://www.medworm.com/index.php?rid=5617142&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00923.x Conclusions:  The present study indicates that 99mTc‐MIBI liver scintigraphy would be a useful non‐invasive functional imaging method with which to evaluate disease activity of NAFLD and distinguish NASH from simple steatosis. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5617142 Wed, 18 Jan 2012 05:00:00 +0100 5617142 http://www.medworm.com/index.php?rid=5617141&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00958.x Conclusions:  This meta‐analysis supports that the TGF‐β1 C‐509T polymorphism may act in a protecting role in HCC susceptibility in populations with related liver disease. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5617141 Wed, 18 Jan 2012 05:00:00 +0100 5617141 http://www.medworm.com/index.php?rid=5617140&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00959.x Conclusions:  These results suggest that on first HCC recurrence, a curative treatment should be considered in order to prevent a second recurrence if possible. In addition, IFN therapy contributes to improved prognosis after curative treatment, even in patients with recurrent HCC. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5617140 Wed, 18 Jan 2012 05:00:00 +0100 5617140 http://www.medworm.com/index.php?rid=5593275&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2012.00966.x Conclusions:  Individuals with undiagnosed HCV infection need to be identified and receive medical care. They have to be motivated to merit from this healthcare program. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5593275 Thu, 12 Jan 2012 05:00:00 +0100 5593275 http://www.medworm.com/index.php?rid=5593274&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2012.00968.x Conclusions:  Our data suggest that contamination of the fetus in the birth canal with infected maternal blood is a major risk factor for HCV MTCT, in addition to maternal HVL. To rationalize intervention by elective cesarean section, the natural history of infected children should be carefully evaluated. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5593274 Thu, 12 Jan 2012 05:00:00 +0100 5593274 http://www.medworm.com/index.php?rid=5593279&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00951.x Conclusion:  A comprehensive mouse cholangiocyte cDNA expression library has been generated and is available for use as a source of multiple cholangiocyte‐specific antigens for immunological studies. The library can be used to screen for specificity of T cell lines or hybridomas. Furthermore, this library has potential uses in SEREX analysis of autoantibody reactivity. The cholangiocyte‐specific cDNA library is a powerful tool for the identification of target antigens in murine inflammatory cholangiopathies and is available as a shared resource. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5593279 Wed, 11 Jan 2012 05:00:00 +0100 5593279 http://www.medworm.com/index.php?rid=5593278&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00955.x Autophagy is a stress response that is upregulated in response to signals such as starvation, growth factor deprivation, endoplasmic reticulum stress, and pathogen infection. Defects in this pathway are the underlying cause of a number of diseases, including metabolic aberrations, infectious diseases, and cancer, which are closely related to hepatic disorders. To date, more than 30 human ATG (autophagy) genes have been reported to regulate autophagosome formation. In this review, we summarize the current understanding of how ATG proteins behave during autophagosome formation in both non‐selective and selective autophagy. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5593278 Wed, 11 Jan 2012 05:00:00 +0100 5593278 http://www.medworm.com/index.php?rid=5593277&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00957.x Conclusions:  Hypoalbuminemia and elevated ICG R15 in hepatitis virus related cirrhotic patients with FPG level of <126 mg/day enhance diabetes pattern after OGTT with significant difference. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5593277 Wed, 11 Jan 2012 05:00:00 +0100 5593277 http://www.medworm.com/index.php?rid=5593276&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00960.x Conclusions:  Development of diet‐induced obesity in the mouse increased inflammatory macrophages counts in adipose tissue rather than the liver. This was associated with greater increases in MMP expression in adipose tissue compared with liver. We propose that attenuated hepatic MMP expression in livers and adipose tissue of obese mice shifts the balance of fibrogenesis/fibrolysis and predispose the liver to development of fibrosis. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5593276 Wed, 11 Jan 2012 05:00:00 +0100 5593276 http://www.medworm.com/index.php?rid=5573297&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00953.x Conclusions:  Hepatitis C virus core protein has the distinct potential to transcriptionally upregulate and sustain HIF‐1α expression under hypoxia, thereby contributing to increased VEGF expression, a key regulator in the hypoxic milieu of liver cirrhosis. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5573297 Fri, 06 Jan 2012 05:00:00 +0100 5573297 http://www.medworm.com/index.php?rid=5573298&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00946.x Conclusions:  This newly developed serum assay specific for P4NP 7S was highly related to liver fibrosis and correlated to extent of hepatic fibrosis. This assay may improve fibrosis quantification. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5573298 Thu, 05 Jan 2012 05:00:00 +0100 5573298 http://www.medworm.com/index.php?rid=5573300&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00936.x Conclusions:  Contrast‐enhanced ultrasonography surveillance for HCC is a cost‐effective strategy for LC patients and gains their longest additional life years, with similar degree of ICER in the US surveillance group. CEUS surveillance using Sonazoid is expected to be used not only in Japan, but also world‐wide. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5573300 Tue, 03 Jan 2012 05:00:00 +0100 5573300 http://www.medworm.com/index.php?rid=5573299&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00947.x Conclusion:  Epigallocatechin‐3‐gallate sensitizes HCC cells to 5‐FU antitumor activity, and the combination of EGCG and 5‐FU exhibits synergism in chemo‐resistant cancer cells. The results suggest potential novel therapies for the treatment of advanced‐stage liver cancer. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5573299 Tue, 03 Jan 2012 05:00:00 +0100 5573299 http://www.medworm.com/index.php?rid=5573296&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00954.x Conclusion:  Loss of CD133 expression supports the hypothesis that IPNB is a counterpart of pancreatic IPMN with a differing carcinogenesis from conventional bile duct adenocarcinomas. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5573296 Sun, 01 Jan 2012 05:00:00 +0100 5573296 http://www.medworm.com/index.php?rid=5523205&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00903.x Klinefelter's syndrome (KS) is a unique physical condition characterized by tall stature, eunuchoid body proportions, gynecomastia, and azoospermia, in addition to an extra X chromosome. In contrast to the original description, symptoms or physical findings can be extremely varied. KS is the most common chromosomal disorder, with an incidence of 1 in 500 males and is also the most commonly undiagnosed chromosomal disorder. Here, we present the case of a 26‐year‐old man with KS, who visited our hospital with complaints of abdominal pain and fever. On a routine physical examination, he did not differ from a normal karyotype male. Computed tomography showed extensive portal and mesenteric vein thrombosis (PMVT). It is well known that KS is frequently associated with venous thrombosis, but... Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5523205 Wed, 21 Dec 2011 14:18:52 +0100 5523205 http://www.medworm.com/index.php?rid=5523191&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00927.x Conclusion:  The ITPA genetic polymorphism does not correlate with post‐transplant PEG‐IFN/RBV‐induced anemia. Splenectomy is useful in preventing anemia regardless of the ITPA genotype. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5523191 Wed, 21 Dec 2011 14:18:05 +0100 5523191 http://www.medworm.com/index.php?rid=5523197&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00939.x Conclusion:  Balloon‐occluded retrograde transvenous obliteration may be superior to endoscopic injection with CA and EO for prevention of rebleeding in patients with isolated fundal GVs with a major shunt. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5523197 Mon, 19 Dec 2011 05:00:00 +0100 5523197 http://www.medworm.com/index.php?rid=5523196&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00912.x The secretion of bile normally depends on the function of a number of membrane transport systems in hepatocytes and cholangiocytes. The transport of solutes from the blood to the bile is driven by transport systems in the plasma membrane of the basolateral and canalicular surfaces of the hepatocytes. In cholestatic animal models, the expression of hepatobiliary transporters changes in response to functional impairment of the efflux of bile salts and various organic anions. In recent years, several studies have led to an improved understanding of the function and regulation of hepatobiliary transport systems in patients with primary biliary cirrhosis (PBC). This review focuses on the adaptations in hepatobiliary transporters in PBC patients. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5523196 Mon, 19 Dec 2011 05:00:00 +0100 5523196 http://www.medworm.com/index.php?rid=5523195&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00915.x Conclusions:  The incident rates of hepatocellular carcinoma in all the malignancies were approximately 6% in the NAFLD group and two‐thirds in the HCV group. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5523195 Mon, 19 Dec 2011 05:00:00 +0100 5523195 http://www.medworm.com/index.php?rid=5523194&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00920.x Conclusions:  Spontaneously hypertensive rats receiving CD diet showed severe hepatic steatosis associated with reduction of hepatic anti‐oxidant capacity, leading to increased hepatic oxidative stress and tissue damage. Accordingly, hypertension might have a potential effect on the progression of NASH. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5523194 Mon, 19 Dec 2011 05:00:00 +0100 5523194 http://www.medworm.com/index.php?rid=5523193&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00921.x Recently antiviral therapies for chronic hepatitis B using nucleos(t)ide analogues have become standard treatment modalities on the basis of several independent guidelines, starting with those of the American Association for the Study of Liver Diseases (AASLD) and other such organizations and bodies, including the European Association for the Study of the Liver (EASL), the Asian Pacific Association for the Study of the Liver (APASL), and the Japanese Ministry of Health, Labour and Welfare (MHLW)'s research team. The philosophies underlying such treatment strategies are considered basically equivalent. MHLW's guidelines define subjects for medical intervention to be cases measuring alanine aminotransferase (ALT) ≥31 IU/L, with serological hepatitis B virus (HBV) DNA level ≥5 log cop... Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5523193 Mon, 19 Dec 2011 05:00:00 +0100 5523193 http://www.medworm.com/index.php?rid=5523192&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00922.x Hepatocellular carcinoma (HCC) has characteristic features of the coexistence of two life‐threatening conditions, cancer and cirrhosis, which makes prognostic assessment difficult. In addition, the high rate of intrahepatic recurrence is a key feature that correlates with poor prognosis and its prevention is an issue for urgent investigation. Gene expression in the tumor and adjacent liver tissue for the prediction of intrahepatic recurrence of HCC has been extensively investigated. Among them, the expression of progenitor cell feature markers in the cancer cells such as epidermal cell adhesion molecule (EpCAM), cytokeratin 19 (CK19) and CD 133 have been shown to be associated with intrahepatic recurrence of HCC. Gene expression patterns from adjacent tissues were shown to predict early ... Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5523192 Mon, 19 Dec 2011 05:00:00 +0100 5523192 http://www.medworm.com/index.php?rid=5523203&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00926.x Conclusions:  Patients in high risk groups should receive a higher level of HBIG to maintain sufficient amounts of anti‐HBs in the early stage post‐LT, while the patients in low risk groups need a lower level of HBIG administration. Furthermore, the lost amount of anti‐HBs in ascitic fluid post‐LT has minimum impact on the anti‐HBs titres in blood. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5523203 Fri, 16 Dec 2011 05:00:00 +0100 5523203 http://www.medworm.com/index.php?rid=5523202&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00930.x Conclusions:  IFNβ/RBV therapy was associated with a lower incidence of depression symptom onset during treatment. In patients already diagnosed with depression, there was no evidence that IFNβ/RBV therapy caused any worsening of symptoms, indicating that IFNβ/RBV therapy is safe for patients with depression. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5523202 Fri, 16 Dec 2011 05:00:00 +0100 5523202 http://www.medworm.com/index.php?rid=5523201&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00942.x Conclusion:  Cisplatin‐iodized oil suspensions facilitated the slow release of cisplatin at the tumor border. A suspension is preferable to an emulsion for drug delivery and the antitumor effect during the treatment of VX2 liver tumors with TACE. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5523201 Fri, 16 Dec 2011 05:00:00 +0100 5523201 http://www.medworm.com/index.php?rid=5523200&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00934.x Conclusions:  Increased hepatic ceramide generation and release may mediate both hepatic and peripheral insulin resistance in NAFLD. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5523200 Fri, 16 Dec 2011 05:00:00 +0100 5523200 http://www.medworm.com/index.php?rid=5523199&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00944.x Conclusions:  Weight‐based lower‐dose ribavirin regimen was not equivalent to the higher‐dose counterpart in the treatment of HCV genotype 2. We discourage treating these patients with low‐dose ribavirin regimens. The peginterferon therapy in combination with ribavirin at a weight‐based higher dose (600–1000 mg) remains the standard‐of‐care treatment for this genotype. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5523199 Fri, 16 Dec 2011 05:00:00 +0100 5523199 http://www.medworm.com/index.php?rid=5523198&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00943.x Conclusion:  As for advanced HCC with VTT of Vv2/3, HAIC‐5‐FU/IFN responsive patients could obtain favorable survival. Despite ineffective HAIC‐5‐FU/IFN, the combination with effective radiotherapy to VTT might improve patients' prognosis. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5523198 Fri, 16 Dec 2011 05:00:00 +0100 5523198 http://www.medworm.com/index.php?rid=5523204&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00938.x Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. The most common problem associated with HCC is a high risk of intrahepatic recurrence despite radical treatment, and in many patients, this recurrence has fatal consequences. For patients with advanced‐stage HCC according to the Barcelona Clinic Liver Cancer staging system, the multikinase inhibitor sorafenib is the current standard of care. In contrast, hepatic arterial infusion chemotherapy (HAIC) is the recommended treatment in Japan for patients with intermediate‐stage or advanced‐stage HCC. In this review, we describe the use of HAIC for advanced HCC. Furthermore, we demonstrate an alternative therapy for HCC, the iron chelator deferoxamine, and discuss future therapeutic possibilities. (Source: Hepatolo... Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5523204 Tue, 13 Dec 2011 05:00:00 +0100 5523204 http://www.medworm.com/index.php?rid=5503874&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00908.x Conclusions:  Choledocoenterostomy and liver atrophy may increase the risk of developing cholangiocarcinoma. Choledocoenterostomy is thus contraindicated in patients with hepatolithiasis. An aggressive resection strategy is recommended for an atrophic segment. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5503874 Tue, 13 Dec 2011 05:00:00 +0100 5503874 http://www.medworm.com/index.php?rid=5503873&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00919.x Conclusions:  Fujiwara et al. reported a frequency of HAV subgenotype IIIA of only 2.1% in Japan. We conclude that HAV subgenotype IIIA might be widespread in our country. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5503873 Tue, 13 Dec 2011 05:00:00 +0100 5503873 http://www.medworm.com/index.php?rid=5503872&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00928.x Transient elastgraphy, acoustic radiation force impulse and real‐time elastography are the methods with very good or excellent diagnostic accuracy for the assessment of liver fibrosis stage. They do not provide the information on inflammatory activity, steatosis, iron deposition or other findings derived from liver biopsy. Even on account of fibrosis stage, these non‐invasive methods do not give us the estimation completely corresponding to that of liver biopsy. However they provide us useful clinical information that liver biopsy has been providing us, such as appropriate time to start antiviral therapy, prediction of response to antiviral therapy, evaluation of effects of antiviral therapy, assessment of natural course of hepatitis and estimation of prognosis of hepatitis. Recently n... Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5503872 Tue, 13 Dec 2011 05:00:00 +0100 5503872 http://www.medworm.com/index.php?rid=5503871&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00929.x Conclusions:  NBNC‐HCC has gradually been increasing in recent years. The present study elucidated that the presence of NASH and metabolic syndrome were important risk factors for NBNC‐HCC and suggests that these patients should receive surveillance for HCC development. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5503871 Tue, 13 Dec 2011 05:00:00 +0100 5503871 http://www.medworm.com/index.php?rid=5503870&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00935.x Conclusions:  Obesity was not common in cirrhotic ALD. Psychological disorders seem to be important for female ALD. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5503870 Tue, 13 Dec 2011 05:00:00 +0100 5503870 http://www.medworm.com/index.php?rid=5503869&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00933.x Conclusion:  Cucurbitacin B has a potential value for suppressing metastasis of human hepatoma cells through suppressing the expression of MMP‐9. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5503869 Tue, 13 Dec 2011 05:00:00 +0100 5503869 http://www.medworm.com/index.php?rid=5503868&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00937.x The use of tumor necrosis factor‐α (TNF‐α) inhibitors has been increasing especially in patients with rheumatoid arthritis (RA). As TNF‐α inhibitors are strongly immunosuppressive, the occurrence of hepatitis B virus (HBV) reactivation has recently been observed. Reports suggest a higher risk of complicating HBV reactivation in carriers who are treated with TNF‐α inhibitors. Therefore, HBV carriers are recommended to undergo prophylactic administration of nucleos(t)ide analogs (NAs). Our literary analysis uncovered several characteristics of de novo hepatitis B due to TNF‐α inhibitors. First, the time between the start of TNF‐α inhibitors and the occurrence of de novo hepatitis was longer than one year. Second, patients were usually treated with additional non‐biologic ... Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5503868 Tue, 13 Dec 2011 05:00:00 +0100 5503868 http://www.medworm.com/index.php?rid=5486148&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00914.x Conclusion:  These results indicate the importance of preserving splenic tissue. This residual spleen may play an important role in preventing the progression from diet‐induced hepatic steatosis to steatohepatitis. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5486148 Mon, 05 Dec 2011 05:00:00 +0100 5486148 http://www.medworm.com/index.php?rid=5486147&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00916.x Conclusion:  A biweekly low‐dosage peginterferon α‐2a therapy is effective for reducing the serum levels of ALT and AFP and may reduce hepatocarcinogenesis in patients with liver cirrhosis and in the elderly individuals. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5486147 Mon, 05 Dec 2011 05:00:00 +0100 5486147 http://www.medworm.com/index.php?rid=5486146&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00917.x Conclusions:  Hepatic resection is an effective and safe treatment for liver metastases mainly depending on primary tumor sites. Hepatic metastases from non‐colorectal gastrointestinal cancer, pulmonary and pancreatobiliary malignancies have the worst prognosis; those from breast and genitourinary neoplasm show the best prognosis. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5486146 Mon, 05 Dec 2011 05:00:00 +0100 5486146 http://www.medworm.com/index.php?rid=5486145&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00918.x Conclusion:  Multidetector computed tomography combined with MPR and liver CTA images are helpful in the diagnosis and differential diagnosis of HVOD and in the evaluation of clinical therapeutic effects. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5486145 Thu, 01 Dec 2011 05:00:00 +0100 5486145 http://www.medworm.com/index.php?rid=5449934&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00940.x (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5449934 Mon, 28 Nov 2011 08:00:36 +0100 5449934 http://www.medworm.com/index.php?rid=5449933&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00877.x A 57‐year‐old woman was admitted to our hospital with characteristic aging of the face and thin body. Before admission, she had been treated for diabetes mellitus type 2 and had undergone amputation of the right leg due to ischemic disease. Abdominal computed tomography revealed primary liver tumor. Biopsy of the liver mass revealed poorly differentiated adenocarcinoma, not hepatocellular carcinoma. Genetic sequencing indicated a homozygous mutation in the Werner syndrome gene (WRN) and she was diagnosed with Werner syndrome with primary liver tumor. She declined medications for the liver tumor and eventually died 6 months after diagnosis. Werner syndrome is a rare autosomal recessive disorder associated with premature aging, and most cases of Werner syndrome have been reported from ... Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5449933 Mon, 28 Nov 2011 08:00:34 +0100 5449933 http://www.medworm.com/index.php?rid=5449932&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00875.x Intrahepatic cholangiocarcinoma (ICC) is one of the life‐threatening complications of primary sclerosing cholangitis (PSC). However, the incidence of ICC in Japanese PSC patients is low, and the association between the development of ICC and morbidity duration of PSC is largely unknown. Here, we describe a case of ICC that developed after a long‐term follow‐up of a patient with PSC and ulcerative colitis (UC). At the age of 10 years, the patient was first diagnosed with UC and its remission was achieved with systemic steroid therapy. Since then, he was routinely followed‐up. At the age of 19 years, laboratory tests showed abnormalities in liver function parameters, and the patient was diagnosed with PSC. Although treatment with ursodeoxycholic acid improved the abnormalities in... Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5449932 Mon, 28 Nov 2011 08:00:32 +0100 5449932 http://www.medworm.com/index.php?rid=5449931&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00870.x Conclusion:  The association between XPNPEP1 rs17095355 polymorphism and BA has been demonstrated, particularly with the T allele. We hypothesize that the XPNPEP1 rs17095355 polymorphism confers increased susceptibility to the disease. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5449931 Mon, 28 Nov 2011 08:00:31 +0100 5449931 http://www.medworm.com/index.php?rid=5449930&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00911.x Conclusions:  Advanced oxidation protein products were suitable for monitoring the levels of oxidative stress in ACLF patients. Increased AOPP may serve as an important biological marker of worse outcome. In addition, PE therapy was effective in reducing AOPP. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5449930 Mon, 28 Nov 2011 08:00:06 +0100 5449930 http://www.medworm.com/index.php?rid=5432675&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00907.x Conclusions:  The efficacy and safety of PEG‐IFN α‐2b plus RBV combination therapy for patients with chronic HCV infection are similar for patients with NALT and those with elevated ALT levels. These results indicate that patients with NALT should be considered for treatment with PEG‐IFN α‐2b plus RBV. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5432675 Tue, 22 Nov 2011 05:00:00 +0100 5432675 http://www.medworm.com/index.php?rid=5432674&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00909.x Conclusions:  A single imDC infusion followed by a short postoperative course of Rapa prolongs liver allograft survival and enhances the expansion of Treg cells. This optimal protocol may be a promising administration protocol for the peritransplant tolerance induction. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5432674 Tue, 22 Nov 2011 05:00:00 +0100 5432674 http://www.medworm.com/index.php?rid=5432673&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00910.x Conclusions:  It appears that negative results for hepatitis B e antigen and serum HBV DNA lower than 3.0 log copies/mL are essential for successful NA discontinuation, which may be attained by a longer treatment period. Levels of hepatitis B surface and core‐related antigens are also significant factors independently associated with relapse of hepatitis. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5432673 Tue, 22 Nov 2011 05:00:00 +0100 5432673 http://www.medworm.com/index.php?rid=5371403&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00881.x Conclusions:  Using a combination of the SOCS3 immunostained area in the liver and the expression of IL28B single nucleotide polymorphisms might be a useful predictor of hepatitis C virus clearance by interferon therapy. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5371403 Wed, 02 Nov 2011 04:00:00 +0100 5371403 http://www.medworm.com/index.php?rid=5371402&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00902.x Conclusion:  Novel scoring system for predicting the outcome of ALF patients may be useful to determine the indication of liver transplantation, since the system showed high predictive accuracy even after validation. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5371402 Wed, 02 Nov 2011 04:00:00 +0100 5371402 http://www.medworm.com/index.php?rid=5371401&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00904.x While a certain international consensus has been reached regarding the diagnosis and treatment of autoimmune hepatitis (AIH), there are some unique clinical characteristics of AIH in Japan. For diagnosis of AIH using the new simplified criteria proposed by the International Autoimmune Hepatitis Group, it is necessary to re‐evaluate the antibody titer determined by using HEp‐2 cells, which are widely used in Japan, and the finding of emperipolesis in liver histology, although the criteria are useful for rapid identification of AIH in routine clinical practice. The use of azathioprine as first‐line therapy for AIH is limited in Japan because the drug is not covered by the Japanese national health insurance. Concomitant use of ursodeoxycholic acid (UDCA) to reduce corticosteroids and us... Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5371401 Wed, 02 Nov 2011 04:00:00 +0100 5371401 http://www.medworm.com/index.php?rid=5371400&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00905.x Conclusions:  FAIT exerts modest antitumor effects and poses no particular safety concerns. FAIT may be a strategy of choice worth trying for advanced HCC with high degree of vascular invasion, which is associated with poor prognosis. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5371400 Wed, 02 Nov 2011 04:00:00 +0100 5371400 http://www.medworm.com/index.php?rid=5371399&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00906.x Conclusion:  The findings suggest that protective effect of G. lucidum against hepatic damage could be mediated by ameliorating the oxidative stress; restoring the mitochondrial enzyme activities and membrane potential. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5371399 Tue, 01 Nov 2011 04:00:00 +0100 5371399 http://www.medworm.com/index.php?rid=5356500&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00865.x Radiofrequency ablation (RFA) is commonly used for treating unresectable hepatic malignancies. Some commonly associated complications of RFA include fever, symptomatic pleural effusion, abscess, hepatoma and hepatic insufficiency. Here, we report a case of diaphragmatic hernia in a patient following RFA for hepatic malignancy with cirrhosis. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5356500 Fri, 28 Oct 2011 12:40:49 +0100 5356500 http://www.medworm.com/index.php?rid=5356499&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00853.x In conclusion, it is possible to eradicate HCV after LT by inducing VR with continuous IFN therapy to before LT in spite of viral and host evidences reflecting low susceptibility to IFN treatment. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5356499 Fri, 28 Oct 2011 12:40:48 +0100 5356499 http://www.medworm.com/index.php?rid=5356498&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00863.x Conclusions:  We devised a method for increasing the reduced albumin fraction in an HSA preparation by using SNMC. We also determined the time‐and dose‐differences in the effect of SNMC on redox state of HSA. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5356498 Fri, 28 Oct 2011 12:40:46 +0100 5356498 http://www.medworm.com/index.php?rid=5356497&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00868.x Conclusions:  CREB dysfunction, mediated by PKA and iPLA2 suppression, may be involved in the deteriorated liver regeneration in the cirrhotic rats. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5356497 Fri, 28 Oct 2011 12:40:44 +0100 5356497 http://www.medworm.com/index.php?rid=5356496&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00856.x Conclusion:  Our pilot study warrants further studies of 1,7‐DMX as a potential new drug to fight fibrotic processes, not just of the liver. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5356496 Fri, 28 Oct 2011 12:40:43 +0100 5356496 http://www.medworm.com/index.php?rid=5356495&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00857.x Conclusions:  Hepatocellular carcinoma disease control was the most significant and independent factor for aggravation of EV and overall survival in HCC patients with major portal vein tumor thrombosis treated with HAIC. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5356495 Fri, 28 Oct 2011 12:40:34 +0100 5356495 http://www.medworm.com/index.php?rid=5356494&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00882.x (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5356494 Fri, 28 Oct 2011 12:40:29 +0100 5356494 http://www.medworm.com/index.php?rid=5356493&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00896.x Human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are a potent source for unlimited production of hepatocytes and hepatocyte‐like cells that may replace primary human hepatocytes in a variety of fields including liver cell therapy, liver tissue engineering, manufacturing bioartificial liver, modeling inherited and chronic liver diseases, drug screening and toxicity testing. Human ESCs are able to spontaneously form embryoid bodies, which then spontaneously differentiate to various tissue‐specific cell lineages containing a total of 10–30% albumin‐producing hepatocytes and hepatocyte‐like cells. Enrichment of embryoid bodies with the definitive endoderm, from which hepatocytes arise, yields increasing the final ratio of hepatocyte population up by 50–6... Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5356493 Fri, 28 Oct 2011 12:40:16 +0100 5356493 http://www.medworm.com/index.php?rid=5305242&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00883.x Conclusions:  We found a 3‐SNP haplotype of the AGT gene that is involved in the development of NASH and influences hypertension in NASH patients. These results provide new insight into the therapy of NASH patients with the CTA haplotype using ACE inhibitors or angiotensin II type 1 receptor blockers. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5305242 Tue, 11 Oct 2011 04:00:00 +0100 5305242 http://www.medworm.com/index.php?rid=5305241&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00890.x Conclusions:  On currently available evidence, laparoscopic resection appears not to affect oncologic outcomes and increase tumor recurrence. It also offers less blood loss, decreased rate of intraoperative transfusion and shorter lengths of hospital stay. Laparoscopic resection is a safe and feasible choice for selected patients with HCC. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5305241 Tue, 11 Oct 2011 04:00:00 +0100 5305241 http://www.medworm.com/index.php?rid=5305240&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00891.x Conclusions:  Results indicate that TJ‐135 inhibits the induction of iNOS at both transcriptional and post‐transcriptional steps, leading to the prevention of NO production. TJ‐135 may have therapeutic potential for various liver injuries through the suppression of iNOS induction. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5305240 Tue, 11 Oct 2011 04:00:00 +0100 5305240 http://www.medworm.com/index.php?rid=5305239&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00892.x Conclusions:  Heterogeneous hypoattenuation on unenhanced CT was a characteristic CT imaging feature of autoimmune acute liver failure compared with viral ALF. This finding could be one of the tools for diagnosing autoimmune acute liver failure in combination with clinicopathological features. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5305239 Tue, 11 Oct 2011 04:00:00 +0100 5305239 http://www.medworm.com/index.php?rid=5305238&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00893.x Conclusion:  Activation of human HSC is suppressed by human platelets or platelet‐derived ATP via adenosine‐cAMP signaling pathway in vitro. Therefore, platelets have the possibility to be used in the treatment of liver cirrhosis. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5305238 Tue, 11 Oct 2011 04:00:00 +0100 5305238 http://www.medworm.com/index.php?rid=5305237&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00894.x Conclusions:  Patients fulfilling all four parameters will be successfully treated without LT. In patients fulfilling any three parameters, intensive care including artificial liver support in expectation of hepatic regeneration during a few weeks may be possible. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5305237 Tue, 11 Oct 2011 04:00:00 +0100 5305237 http://www.medworm.com/index.php?rid=5305243&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00880.x Conclusions:  Applying QIs to the liver cancer registry, the quality of hepatocellular carcinoma care can be measured. In future, providing feedback regarding the results to the participating society may improve the quality of liver cancer care nationwide. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5305243 Fri, 07 Oct 2011 04:00:00 +0100 5305243 http://www.medworm.com/index.php?rid=5292778&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00855.x Conclusion:  We confirmed that pediatric NAFLD exhibits histopathological features that are different from adult NAFLD. The classification consisting of “type 1 NASH” and “type 2 NASH” may be impractical. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5292778 Mon, 03 Oct 2011 04:00:00 +0100 5292778 http://www.medworm.com/index.php?rid=5292777&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00862.x Conclusion:  This score was validated for the prediction of liver fibrosis stages and may minimize the need for liver biopsy. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5292777 Sat, 01 Oct 2011 04:00:00 +0100 5292777 http://www.medworm.com/index.php?rid=5271211&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00884.x Conclusions:  The present protocol for HBIg administration, which used frequent monitoring of HBsAg and HBsAb levels to determine the minimum required dose, was both safe and effective, and contributed to overall cost saving after liver transplantation. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5271211 Sat, 01 Oct 2011 04:00:00 +0100 5271211 http://www.medworm.com/index.php?rid=5255124&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00861.x (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5255124 Mon, 26 Sep 2011 15:04:48 +0100 5255124 http://www.medworm.com/index.php?rid=5255123&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00850.x Genetic variants of the innate immune system contribute to episodes of spontaneous bacterial peritonitis (SBP) in patients with cirrhosis. We herein report the case of a patient with the homozygous nucleotide‐binding oligomerization domain containing 2 (NOD2) frame‐shift mutation 1007fs presenting with sepsis and community‐acquired SBP by Escherichia coli. Secondary peritonitis, pancreatic ascites and malignant causes were excluded by extensive diagnostic work‐up. First‐line treatment with ceftriaxone was not successful despite in vitro sensitivity of the isolated strain. Despite prolonged second‐line treatment with imipenem/cilastatin and intermittent ascites drainage, the ascitic fluid neutrophil count remained markedly elevated in this patient. In the course of the disease t... Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5255123 Mon, 26 Sep 2011 15:04:47 +0100 5255123 http://www.medworm.com/index.php?rid=5255122&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00854.x Conclusion:  Unlike other malignancies studied to date, in this study, the proliferative activity of malignant hepatocytes was not increased by exposure to AR agonists, a finding that could be explained by downregulation of β2‐AR expression. The increase in malignant hepatocyte migration observed remains unexplained but does not appear to involve adenyl cyclase or MMP signaling pathways. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5255122 Mon, 26 Sep 2011 15:04:45 +0100 5255122 http://www.medworm.com/index.php?rid=5255121&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00852.x Conclusion:  The TNF‐α and IL‐6 expression of LPS‐stimulated KC was inhibited by GITRL gene silencing. Dexamethasone attenuates LPS‐induced liver injury, at least proportionately, by downregulating GITRL in KC. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5255121 Mon, 26 Sep 2011 15:04:44 +0100 5255121 http://www.medworm.com/index.php?rid=5255120&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00885.x (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5255120 Mon, 26 Sep 2011 15:04:31 +0100 5255120 http://www.medworm.com/index.php?rid=5255119&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00895.x Liver fibrosis has been gaining noticeable attention because it may lead to end‐stage liver cirrhosis and ultimately to hepatocellular carcinoma. Thus, a precise estimation of the degree of liver fibrosis is crucial for predicting prognosis and deciding management of patients with chronic liver diseases. Many non‐invasive approaches for the evaluation of liver fibrosis have been developed. Among these procedures, transient elastography has recently drawn great attention. Transient elastography has been reported to be well correlated with the degree of liver fibrosis by many investigators and various institutions. Since the degree of liver fibrosis is considered as a strong predictor of risk for hepatocellular carcinoma development, several trials have been performed to verify the usefu... Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5255119 Mon, 26 Sep 2011 15:04:29 +0100 5255119 http://www.medworm.com/index.php?rid=5255118&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00867.x This article reviews the clinical background, pathogenesis, new diagnostic approaches and future directions regarding NAFLD/NASH. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5255118 Mon, 26 Sep 2011 15:04:27 +0100 5255118 http://www.medworm.com/index.php?rid=5255109&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00879.x Conclusion:  Evaluation of viral reduction at week 2 after therapy initiation is useful for predicting SVR to low‐dose PEG‐IFN plus ribavirin therapy. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5255109 Mon, 26 Sep 2011 15:04:04 +0100 5255109 http://www.medworm.com/index.php?rid=5255114&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00886.x Conclusions:  In CH‐C patients infected with genotype 2 treated by PEG‐IFNα2b and RBV combination therapy, hepatic steatosis >10% was associated with increased insulin resistance, advanced hepatic fibrosis and higher cumulative positivity of serum HCV RNA, which lead to a higher risk of non‐SVR. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5255114 Mon, 26 Sep 2011 04:00:00 +0100 5255114 http://www.medworm.com/index.php?rid=5255113&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00888.x Conclusions:  Ezetimibe attenuated steatosis and liver fibrosis by reducing oxidative stress and lipid peroxidation and suppressing activated hepatic stellate cells and Kupffer cells. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5255113 Mon, 26 Sep 2011 04:00:00 +0100 5255113 http://www.medworm.com/index.php?rid=5255112&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00887.x Conclusions:  Re‐treatment with PEG‐IFN α2a plus ribavirin therapy is effective in patients who relapse after a course of PEG‐IFN α2b plus ribavirin therapy. Re‐treatment is a particularly useful option for patients who achieve early viral clearance during previous therapy. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5255112 Mon, 26 Sep 2011 04:00:00 +0100 5255112 http://www.medworm.com/index.php?rid=5255111&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00889.x Hepatocellular carcinoma (HCC) is mainly caused by a persistent infection due to the hepatitis B or hepatitis C virus. The number of HCC cases is increasing in Asian and African countries, as well as in European and American countries. Interferon (IFN) therapy, used for type B chronic liver diseases, inhibits hepatic carcinogenesis in patients with compensated cirrhosis. However, there is insufficient evidence that IFN therapy inhibits hepatic carcinogenesis in patients with chronic hepatitis B. There are few cases of HCC due to chronic hepatitis B, and long‐term follow‐up periods verifying the inhibitory effect of IFN on hepatic carcinogenesis have not been obtained. To improve the prognosis of type B chronic liver diseases, it is important that hepatitis treatment follows guidelines ... Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5255111 Mon, 26 Sep 2011 04:00:00 +0100 5255111 http://www.medworm.com/index.php?rid=5255110&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00878.x Conclusions:  The rapid reduction of HCV‐Core antigens and changes in the distribution of lymphoid cells could contribute to the favorable immunological response during DFPP/Peg‐IFN/RBV therapy. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5255110 Mon, 26 Sep 2011 04:00:00 +0100 5255110 http://www.medworm.com/index.php?rid=5255117&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00874.x Regenerative medicine using stem cells has attracted much attention, since stem cells are responsible for highly proliferative activity and multipotential ability of differentiation. Induced pluripotent stem cells and embryonic stem cells or the adult stem cells such as bone marrow‐derived stem cells and adipose tissue‐derived stem cells have been expected as a cell source of regenerative medicine. Since differentiating methods of human stem cells into the defined lineage of cells remains to be developed, we focus on the differentiating strategies of pluripotent stem cells and mesenchymal stem cells into liver lineage, especially on cytokine function and gene expression during hepatic differentiation. The survey of previously published papers discloses that the protocols that mimic the... Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5255117 Thu, 22 Sep 2011 04:00:00 +0100 5255117 http://www.medworm.com/index.php?rid=5255116&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00864.x Conclusion:  The present data suggest that the anti‐hypoalbuminemic effect of BCAA treatment in patients with liver cirrhosis is independent of dietary intake. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5255116 Thu, 22 Sep 2011 04:00:00 +0100 5255116 http://www.medworm.com/index.php?rid=5255115&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00849.x Conclusion:  NASH‐related metabolic parameters improved with therapy including histology in some patients. However, three of 13 patients had progression of fibrosis during the treatment. Our pilot study demonstrated the efficacy of pitavastatin for the treatment of NASH with dyslipidemia, especially with hyperlipoproteinemia type IIb and controlled trials are needed in the future. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5255115 Thu, 22 Sep 2011 04:00:00 +0100 5255115 http://www.medworm.com/index.php?rid=5224306&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00869.x Conclusions:  Liver stiffness, measured by transient elastography, of chronic hepatitis B patients treated with NA showed a rapid decline in the first 3 years followed by a more steady transition for from 3 to 5 years irrespective of long term virological effect. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5224306 Thu, 15 Sep 2011 04:00:00 +0100 5224306 http://www.medworm.com/index.php?rid=5224305&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00871.x Conclusions:  Serum DCP levels may be raised in end‐stage liver disease patients without HCC, and cannot be used as a reliable marker for HCC among liver transplant candidates. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5224305 Thu, 15 Sep 2011 04:00:00 +0100 5224305 http://www.medworm.com/index.php?rid=5224304&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00872.x The incidence of hepatocellular carcinoma in non‐viral‐related chronic liver disease has gradually increased in Japan. Obesity and diabetes mellitus type 2 have been established as a significant risk factor for hepatocellular carcinoma (HCC) by epidemiologic observations and experimental studies. The risks of these factors for HCC are likely conferred by two factors: the increased risk for development of non‐alcoholic steatohepatitis (NASH) and the carcinogenic potential of themselves. Hepatocellular carcinoma in NASH is difficult to evaluate because histological diagnosis is required for diagnosis of NASH, which can lead selection bias. Furthermore, end‐stage NASH is in effect “burned‐out” NASH, for which the diagnosis of NASH cannot be made any more. At all events, previous... Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5224304 Thu, 15 Sep 2011 04:00:00 +0100 5224304 http://www.medworm.com/index.php?rid=5224303&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00873.x Nucleos(t)ide analogs (NAs) have become the mainstream drugs for the treatment of chronic hepatitis B virus infection. Drug resistance to NAs, however, has posed a major obstacle in obtaining sustained viral suppression. Standardized definitions of terms and nomenclature in discussing NAs resistance have been proposed. Drug resistance to NAs is produced by a combination of viral, host and antiviral drug factors. A detailed understanding of the mechanisms and effects of mutation sites that cause resistance to NAs is important for the design of rational treatment and management of patients with existing drug resistance. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5224303 Thu, 15 Sep 2011 04:00:00 +0100 5224303 http://www.medworm.com/index.php?rid=5224302&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00876.x Conclusion:  Based on the present analysis, we concluded a sequential model of the initial proliferation in residual hepatocytes, and for the first time, quantitatively elucidated the proliferation manner of three subpopulations during liver regeneration. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5224302 Thu, 01 Sep 2011 04:00:00 +0100 5224302 http://www.medworm.com/index.php?rid=5170104&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00837.x A 58‐year‐old woman with chronic hepatitis C developed interstitial pneumonia (IP) while undergoing pegylated interferon (PEG IFN)‐α‐2a and ribavirin (RBV) therapy. Serum levels of sialylated carbohydrate antigen KL‐6 (KL‐6), a known marker of disease activity in fibrosing lung disorders, had been regularly measured once a month for early detection of IP, and had begun rising noticeably from 12 weeks to 540 U/mL at 33 weeks of treatment. On examination, remarkable fine crackles were detected by dorsal auscultation and bilateral ground‐glass opacities and reticular shadows were depicted by computed tomography. The patient successfully recovered from her early‐stage pneumonia by immediate discontinuation of therapy, which indicates that regular monitoring of serum KL‐6... Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5170104 Mon, 29 Aug 2011 04:52:28 +0100 5170104 http://www.medworm.com/index.php?rid=5170103&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00844.x Conclusion:  In PBC‐AIH overlap, AIH‐like features are dominant in liver histology. The simplified AIH scoring system could predict patients who needed corticosteroids with a higher specificity. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5170103 Mon, 29 Aug 2011 04:52:25 +0100 5170103 http://www.medworm.com/index.php?rid=5170102&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00840.x Conclusion:  Due to extreme scarcity of liver graft, we think that HBsAg‐positive liver graft without active HBV‐DNA replication and severe pathological manifestation from asymptomatic carriers may deserve consideration when no other graft is available in a bearable waiting time. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5170102 Mon, 29 Aug 2011 04:52:23 +0100 5170102 http://www.medworm.com/index.php?rid=5170101&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00860.x The diagnostic criteria of fulminant hepatitis in Japan are different from those of acute liver failure in Europe and the United States, both in regard to the histological features in the liver and the cutoff values of the prothrombin time. Thus, the Intractable Hepato‐Biliary Disease Study Group established novel diagnostic criteria for “acute liver failure” in Japan based on the demographic and clinical features of the patients. Patients showing prothrombin time values of 40% or less of the standardized values or international normalized ratios of 1.5 or more caused by severe liver damage within 8 weeks of onset of the symptoms are diagnosed as having “acute liver failure”, where the liver function prior to the current onset of liver damage is estimated to be normal. Acute li... Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5170101 Mon, 29 Aug 2011 04:52:19 +0100 5170101 http://www.medworm.com/index.php?rid=5170095&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00866.x Conclusion:  These data suggest that XRCC7 rs#7003908 polymorphism may be one of the genetic modifiers for AFB1‐related HCC among Guangxi population. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5170095 Mon, 29 Aug 2011 04:52:12 +0100 5170095 http://www.medworm.com/index.php?rid=5170098&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00851.x Conclusion:  This study suggests that IHCA arising in men with alcoholic liver disease may be a major subtype of HCA in Japan. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5170098 Thu, 25 Aug 2011 23:00:00 +0100 5170098 http://www.medworm.com/index.php?rid=5170097&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00858.x Conclusions:  The µTAS was found to be a highly sensitive assay for AFP‐L3% in patients with curative treatment of HCC. A cutoff value of 5% was useful for predicting recurrence after the curative treatment and detecting small tumors and early stage HCC. Additionally, postoperative AFP‐L3% was found to be a prognostic factor of HCC recurrence. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5170097 Thu, 25 Aug 2011 23:00:00 +0100 5170097 http://www.medworm.com/index.php?rid=5170096&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00859.x Conclusions:  The E‐PAS to output phylogenetic tree was developed since requisite material was sequence data only. E‐PAS could expand to determine HBV genotypes as well as transmission routes. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5170096 Thu, 25 Aug 2011 23:00:00 +0100 5170096 http://www.medworm.com/index.php?rid=5170100&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00845.x Conclusions:  The annual incidence for CKD among cirrhotic patients with HCV was determined to be about 1.0–1.5%. In addition, the annual incidence for end‐stage‐CKD is one order of magnitude lower than that of CKD. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5170100 Tue, 23 Aug 2011 23:00:00 +0100 5170100 http://www.medworm.com/index.php?rid=5170099&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00846.x Conclusions:  Liver stiffness as measured by transient elastography is a predictor of HCC development in viral hepatitis. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5170099 Tue, 23 Aug 2011 23:00:00 +0100 5170099 http://www.medworm.com/index.php?rid=5082396&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00832.x Conclusion:  These results suggest that ICAM‐1 has a diagnostic value in patients with BA and would be a promising helpful tool when investigating patients with NC. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5082396 Sun, 31 Jul 2011 23:00:00 +0100 5082396 http://www.medworm.com/index.php?rid=5082395&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00815.x Conclusion:  NASH is associated with increased insulin resistance and altered ceramide gene expression in liver. Weight loss‐mediated reversal of NASH is associated with reduced pro‐ceramide gene expression in liver. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5082395 Sun, 31 Jul 2011 23:00:00 +0100 5082395 http://www.medworm.com/index.php?rid=5082394&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00831.x Conclusion:  There is evidence that moderate alcohol consumption lowers the risk of EBSC compared with non‐/low alcohol consumption, but not heavy alcohol consumption. Further multicenter and better controlled studies are required to confirm these findings. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=5082394 Sun, 31 Jul 2011 23:00:00 +0100 5082394 http://www.medworm.com/index.php?rid=4993107&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00825.x Although diet and lifestyle changes are the first‐line therapy in patients with non‐alcoholic steatohepatitis (NASH), few patients are able to successfully implement these measures over the long run while others have an advanced disease requiring specific pharmacological therapy. Because insulin resistance is the underlying condition favoring the occurrence of NASH, insulin sensitizers have been tested in this condition although available trials are heterogenous in terms of choice of the drug, dosage, length of therapy and patient profile. Overall, thiazolidinediones reduce aminotransferase levels and induce a strong anti‐steatogenic response. Most studies have shown an improvement in inflammation and liver cell injury while none have convincingly demonstrated an effect on fibrosis r... Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4993107 Thu, 30 Jun 2011 23:00:00 +0100 4993107 http://www.medworm.com/index.php?rid=4993106&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00814.x Non‐alcoholic steatohepatitis (NASH) represents the progression of hepatic steatosis to streatohepatitis, fibrosis and cirrhosis. Three signaling pathways have been associated with this progression; Toll‐like receptors, reactive oxygen species and Jun N‐terminal kinase. This review will describe how activation of these three pathways is required for development of fibrosis in murine models of NASH. The three pathways are related and synergistic through intracellular cross‐talk. Disruption of any of these pathways may inhibit NASH‐induced fibrosis and are potential targets for therapeutic intervention. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4993106 Thu, 30 Jun 2011 23:00:00 +0100 4993106 http://www.medworm.com/index.php?rid=4993105&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00824.x Non‐alcoholic fatty liver disease (NAFLD) is a major public health problem both in the Western world and in the East. This is mainly due to the high prevalence of the disease and its effects on the individual with NAFLD. In the USA, it is estimated that approximately a third of the general population has NAFLD. Increasing age, obesity and the presence of multiple features of metabolic syndrome, especially diabetes, are associated with a higher probability of having non‐alcoholic steatohepatitis (NASH). In the individual with NAFLD, excess hepatic fat is associated with an increased risk of developing diabetes, hypertension, cardiovascular events, abnormal resting electrocardiography and endothelial dysfunction. These findings have been corroborated in studies in teenagers as well as ad... Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4993105 Thu, 30 Jun 2011 23:00:00 +0100 4993105 http://www.medworm.com/index.php?rid=4993104&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00823.x (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4993104 Thu, 30 Jun 2011 23:00:00 +0100 4993104 http://www.medworm.com/index.php?rid=4993103&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00821.x Conclusion:  These findings indicated that the iron chelation exerted a hepatoprotective effect by scavenging ROS upstream of caspase‐3 and that iron chelation with deferasirox is a potential treatment for patients with fulminant hepatitis. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4993103 Thu, 30 Jun 2011 23:00:00 +0100 4993103 http://www.medworm.com/index.php?rid=4993102&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00820.x Conclusion:  The present data demonstrate a beneficial effect of UDCA that manifested by the decrease of liver steatosis, inflammatory signs and serum tumor necrosis factor‐α content especially of the highest 40 and 80 mg/kg day doses. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4993102 Thu, 30 Jun 2011 23:00:00 +0100 4993102 http://www.medworm.com/index.php?rid=4993101&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00812.x Conclusion:  Our results demonstrate the risk factors associated with relapse of AIH. We also show that early administration of AZP after the first relapse may help to prevent additional relapses. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4993101 Thu, 30 Jun 2011 23:00:00 +0100 4993101 http://www.medworm.com/index.php?rid=4993100&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00817.x Conclusion:  Results for RFA using cool‐tip electrodes for liver tumors in high‐risk areas are comparable to those in low‐risk areas in the aspects of CA, complications and mortality. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4993100 Thu, 30 Jun 2011 23:00:00 +0100 4993100 http://www.medworm.com/index.php?rid=4993099&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00811.x Conclusion:  Reduction of ribavirin doses for elderly patients did not affect the outcome for the 48‐week combination therapy. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4993099 Thu, 30 Jun 2011 23:00:00 +0100 4993099 http://www.medworm.com/index.php?rid=4993098&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00813.x The hemodynamic, cellular and metabolic changes seen in patients with cirrhosis may reduce the risk of liver metastases. The aim of this case–control is to compare the risk of liver metastases from extrahepatic malignant diseases among patients with or without cirrhosis. Electronic searches (Medline, Embase, and Web of Science) and manual searches were combined (October 2010) to identify observational studies on patients with malignant disease reporting the risk of liver metastases among cases (with cirrhosis) and controls (without liver disease). Meta‐analysis was performed using random effects models due to an expected clinical heterogeneity. Sixteen studies were included. Evidence of liver metastases was diagnosed in 22% of cases and 38% of controls based on autopsies (n = 14 st... Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4993098 Thu, 30 Jun 2011 23:00:00 +0100 4993098 http://www.medworm.com/index.php?rid=4993097&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00819.x Fluorodeoxyglucose (FDG), which allows the evaluation of glucose metabolism, is widely used for tumor diagnosis using positron emission tomography (PET). FDG‐PET, which is used for the diagnosis of intrahepatic tumor lesions, shows high FDG accumulation in cholangiocellular carcinoma (CCC) and metastatic liver cancer. FDG‐PET shows high FDG accumulation in moderately or poorly differentiated hepatocellular carcinoma (HCC) and is useful for the diagnosis of extrahepatic HCC metastases and recurrences. However, because the imaging method frequently shows low FDG accumulation in well‐differentiated HCC, it is not very useful for that diagnosis. For the diagnosis of well‐differentiated HCC, F‐18 fluorocholine for evaluation of phospholipid metabolism and C‐11 acetate for evaluation... Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4993097 Thu, 30 Jun 2011 23:00:00 +0100 4993097 http://www.medworm.com/index.php?rid=4993096&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00822.x Toll‐like receptors (TLR) are the germline‐coded pattern recognition receptors that sense microbial products. This signaling orchestrates complex signaling pathways that induce expression of inflammatory genes for host defense against invading microorganisms. Recent studies illustrate the role of TLR on non‐infectious inflammatory diseases. The liver has a unique anatomy bridging with the intestine by portal vein and bile ducts. This allows delivery of products from intestinal microflora directly into the liver. Subsequently, microbial products cause acute and chronic inflammation through TLR signaling in the liver. Not only exogenous products, but endogenous denatured products released from dying cells also facilitate inflammation even in sterile conditions. Consequently, these resp... Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4993096 Thu, 30 Jun 2011 23:00:00 +0100 4993096 http://www.medworm.com/index.php?rid=4993084&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00848.x Conclusion:  A new sequence KIs‐V was isolated from blood donors with elevated ALT levels. It was suggested that KIs‐V is a double‐stranded circular DNA genome derived from a novel category of enveloped viruses. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4993084 Thu, 30 Jun 2011 23:00:00 +0100 4993084 http://www.medworm.com/index.php?rid=4993089&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00847.x Conclusion:  Several known risk factors for HCC contributed to HCC in patients who received PEG‐IFN α‐2b and RBV combination therapy, and ALT abnormality after the end of treatment contributes to the onset of HCC in both non‐SVR and SVR patients. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4993089 Mon, 27 Jun 2011 23:00:00 +0100 4993089 http://www.medworm.com/index.php?rid=4993088&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00833.x Conclusion:  Patients with CH‐C could safely walk as aerobic exercise. Furthermore, walking improved insulin resistance and decreased body fat while lowering serum levels of leptin. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4993088 Mon, 27 Jun 2011 23:00:00 +0100 4993088 http://www.medworm.com/index.php?rid=4993087&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00834.x Conclusion:  The prevalence of HCV infection in the Airin district is extremely higher than that in the Japanese general population. Patient education and strict action against illegal drug use are indispensable to prevent the spread of HCV infection from the district. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4993087 Mon, 27 Jun 2011 23:00:00 +0100 4993087 http://www.medworm.com/index.php?rid=4993086&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00835.x Conclusion:  The international scoring system for diagnosis of Wilson disease is a fairly reliable tool for screening Japanese patients who need anti‐copper treatment. Caution is needed for patients with possible idiopathic copper toxicosis because the maximal score is 4 points. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4993086 Mon, 27 Jun 2011 23:00:00 +0100 4993086 http://www.medworm.com/index.php?rid=4993085&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00839.x Conclusion:  Anti‐PHGDH were detected in chronic liver diseases. They occur predominantly in AIH, and corticosteroid treatment seems to decrease antibody titers. Whether the antibodies are primary or secondary phenomena and whether they are related to the etiology or pathogenesis, at least in a subgroup of patients with chronic liver diseases, has still to be evaluated. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4993085 Mon, 27 Jun 2011 23:00:00 +0100 4993085 http://www.medworm.com/index.php?rid=4993094&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00828.x Conclusion:  Our results showed that splenectomy promoted liver regeneration by increasing serotonin content in liver even under cirrhotic conditions. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4993094 Wed, 22 Jun 2011 23:00:00 +0100 4993094 http://www.medworm.com/index.php?rid=4993093&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00830.x Conclusion:  Prednisone suppresses the development of liver fibrosis in HSOS mice by inhibiting TGF‐β1, CTGF, TNF‐α and NF‐κBp65 expression. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4993093 Wed, 22 Jun 2011 23:00:00 +0100 4993093 http://www.medworm.com/index.php?rid=4993092&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00836.x Conclusions:  PB supply to locally progressed tumor after TACE became apparent on CTAP. Arterial damage by TACE, incomplete TACE, and preexisting tumor tissues supplied by PB may be the main causes. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4993092 Wed, 22 Jun 2011 23:00:00 +0100 4993092 http://www.medworm.com/index.php?rid=4993091&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00841.x Conclusions:  The prognosis of patients with neoplastic seeding was poor. In particular, RFA performed for HCC not satisfying the RFA indication showed a high risk of seeding, and careful consideration should be given to the optimal treatment method and avoiding direct puncture of subcapsular tumors. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4993091 Wed, 22 Jun 2011 23:00:00 +0100 4993091 http://www.medworm.com/index.php?rid=4993090&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00843.x Conclusion:  In conclusion, interspousal infection might be one of the important sources of acute HCV infection in Japan. The usefulness of phylogenetic analysis of nucleotide sequences of HCV E1 region for clarifying interspousal HCV infection was validated. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4993090 Wed, 22 Jun 2011 23:00:00 +0100 4993090 http://www.medworm.com/index.php?rid=4993095&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00826.x The treatment of advanced hepatocellular carcinoma (HCC) associated with portal vein tumor thrombosis (PVTT) is very challenging because of HCC's grave prognosis. Despite many efforts to improve the treatment results, patient survival has been limited to several months. In this situation, radiotherapy has been considered as an alternative treatment modality because of the growth of knowledge about the radiotolerance of normal tissue and the advances of radiotherapy techniques such as three dimensional conformal radiotherapy, intensity modulated radiotherapy, stereotactic body radiotherapy and proton therapy. More restoration of the liver function and longer survival of the patients can be achieved by the better response after radiotherapy. However, considering the high risk of intrahepatic... Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4993095 Tue, 21 Jun 2011 23:00:00 +0100 4993095 http://www.medworm.com/index.php?rid=4938267&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00816.x Conclusion:  The SVR of patients infected with HCV genotype 2 depended on the dosage of PEG IFN, but not of RBV. Selecting sufficient doses of PEG IFN for combination with RBV is critical for treating such patients. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4938267 Thu, 16 Jun 2011 23:00:00 +0100 4938267 http://www.medworm.com/index.php?rid=4938266&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00818.x Although chronic infection with hepatitis B virus (HBV) and/or hepatitis C virus (HCV) are the most important risk factors for the development of hepatocellular carcinoma (HCC) worldwide, the proportion of HCC patients negative for the hepatitis B surface antigen and hepatitis C antibody, so‐called “non‐B non‐C HCC”, is rapidly increasing, especially in Japan. The background liver diseases of non‐B non‐C HCC patients can be multifactorial, including occult HBV infection and non‐alcoholic steatohepatitis. It is reasonable to investigate the non‐cancerous liver tissues to identify the potential molecular mechanisms responsible for the processes of hepatocarcinogenesis of non‐B non‐C HCC. However, to date, only a few studies have focused on this research concept based on... Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4938266 Thu, 16 Jun 2011 23:00:00 +0100 4938266 http://www.medworm.com/index.php?rid=4938265&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00827.x Conclusions:  AP‐2α is expressed in mouse hepatocytes and it acts as a master regulator of numerous transcription factors in the liver. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4938265 Thu, 16 Jun 2011 23:00:00 +0100 4938265 http://www.medworm.com/index.php?rid=4938264&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00829.x The traditional Chinese herbal medicine Sho‐saiko‐to is a mixture of seven herbal preparations that has long been used in the treatment of chronic liver disease. Various clinical trials have shown that Sho‐saiko‐to protects against the development of hepatocellular carcinoma in cirrhotic patients. However, the mechanism by which Sho‐saiko‐to protects hepatocytes against hepatic fibrosis and carcinoma is not yet known. Basic science studies have demonstrated that Sho‐saiko‐to reduces hepatocyte necrosis and enhances liver function. Sho‐saiko‐to significantly inhibits hepatic fibrosis by inhibiting the activation of stellate cells, the major producers of collagen in the liver, as well as by inhibiting hepatic lipid peroxidation, promoting matrix degradation, and suppressi... Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4938264 Thu, 16 Jun 2011 23:00:00 +0100 4938264 http://www.medworm.com/index.php?rid=4938263&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00838.x Cholesterol is an essential molecule for the life cycle of the hepatitis C virus (HCV). This review focuses on the roles of cholesterol in HCV infection and introduces HCV events related to cholesterol metabolism and applications for cholesterol metabolism as a therapeutic target. HCV appears to alter host lipid metabolism into its preferable state, which is clinically recognized as steatosis and hypocholesterolemia. While hepatic fatty acid and triglyceride syntheses are upregulated in chronic hepatitis C patients, no direct evidence of increased hepatic de novo cholesterol biosynthesis has been obtained. Impaired VLDL secretion from hepatocytes is suggested to increase intracellular cholesterol concentrations, which may lead to hypocholesterolemia. Clinically, lower serum cholesterol lev... Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4938263 Thu, 16 Jun 2011 23:00:00 +0100 4938263 http://www.medworm.com/index.php?rid=4938270&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00806.x Conclusion:  This meta‐analysis suggested that smoking, family history of PBC and UTI were strongly associated with PBC in a white population by systematic review of five existing studies, and the association remains to be validated in other populations. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4938270 Tue, 31 May 2011 23:00:00 +0100 4938270 http://www.medworm.com/index.php?rid=4938269&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00796.x Conclusion:  HBV DNA changes after TACE included reactivated, decreased and stable HBV DNA levels. Although HBV reactivation did not necessarily result in exacerbation of liver damage and most HCC patients with Child–Pugh grade A and B tolerated TACE well, careful post‐procedure monitoring and managing is needed. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4938269 Tue, 31 May 2011 23:00:00 +0100 4938269 http://www.medworm.com/index.php?rid=4938268&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00798.x Conclusion:  Our results indicate that sitagliptin is effective and safe for the treatment of T2DM complicated with HCV positive chronic liver disease. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4938268 Tue, 31 May 2011 23:00:00 +0100 4938268 http://www.medworm.com/index.php?rid=4938262&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00842.x Conclusions:  Liver stiffness measurement by transient elastography is valuable for evaluating fibrotic progression in NAFLD. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4938262 Tue, 31 May 2011 23:00:00 +0100 4938262 http://www.medworm.com/index.php?rid=4847833&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00807.x Conclusion:  In patients treated with LAM for more than 3 years maintaining HBV DNA less than 2.6 log copies/mL, switching treatment to ETV is recommended at least during the 2 years' follow‐up period. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4847833 Tue, 17 May 2011 23:00:00 +0100 4847833 http://www.medworm.com/index.php?rid=4847835&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00809.x Conclusion:  Stiffness of the remaining liver and spleen in the smaller remnant liver group became harder than that in the larger remnant liver group. Perioperative measurement of liver and spleen VTTQ seems to be a useful means for assessing the physiology of liver regeneration. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4847835 Tue, 10 May 2011 23:00:00 +0100 4847835 http://www.medworm.com/index.php?rid=4847831&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00808.x Autoimmune hepatitis (AIH), initially called chronic aggressive hepatitis, is conceptually classified as a primary chronic disease; periportal fibrous expansion and periportal infiltration of mononuclear cells, including plasma cells, have also been considered to be histologically important diagnostic signs of AIH. However, several manuscripts which reported the acute presentation of AIH have been published recently and the reported cases of acute presentation in these manuscripts contained two different clinical entities. One is acute exacerbation of chronic AIH (acute exacerbation form) and the other is genuine acute AIH without chronic histological changes (acute form). It is clinically important to distinguish the acute form from the acute exacerbation form. The reports of the acute fo... Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4847831 Sat, 30 Apr 2011 23:00:00 +0100 4847831 http://www.medworm.com/index.php?rid=4791185&cid=s_35618_49_f&fid=35618&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1872-034X.2011.00788.x Conclusion:  These findings suggest that ATP7B localizes in the late endosomes and that copper in the late endosomes is transported to the secretory compartment via an NPC1‐dependent pathway and incorporated into Cp. (Source: Hepatology Research) Hepatology Research journals http://www.medworm.com/rss/comments.php?id=4791185 Sat, 30 Apr 2011 23:00:00 +0100 4791185