MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Hepatology' source. Mon, 06 Feb 2012 09:02:25 +0100 http://www.medworm.com/index.php?rid=5663244&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25633 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5663244 Mon, 06 Feb 2012 05:00:00 +0100 5663244 http://www.medworm.com/index.php?rid=5663243&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25634 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5663243 Mon, 06 Feb 2012 05:00:00 +0100 5663243 http://www.medworm.com/index.php?rid=5663242&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25636 Conclusion:Presence of only WT virus at baseline is a strong predictor of response (HBeAg loss with HBV DNA <10,000 copies/mL) to PEG‐IFN for HBeAg‐positive CHB. Patients with detectable PC and/or BCP mutants have a lower probability of response and are less optimal candidates for PEG‐IFN therapy. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5663242 Mon, 06 Feb 2012 05:00:00 +0100 5663242 http://www.medworm.com/index.php?rid=5663241&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25637 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5663241 Mon, 06 Feb 2012 05:00:00 +0100 5663241 http://www.medworm.com/index.php?rid=5663240&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25638 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5663240 Mon, 06 Feb 2012 05:00:00 +0100 5663240 http://www.medworm.com/index.php?rid=5663239&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25639 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5663239 Mon, 06 Feb 2012 05:00:00 +0100 5663239 http://www.medworm.com/index.php?rid=5663238&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25641 Conclusion:Our data demonstrate that strain differences in alcohol‐induced liver injury and steatosis are striking and independent of alcohol exposure and the most severely affected strains exhibit major differences in the expression of ER stress markers and genes of one‐carbon metabolism. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5663238 Wed, 01 Feb 2012 05:00:00 +0100 5663238 http://www.medworm.com/index.php?rid=5642299&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.24716 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5642299 Mon, 30 Jan 2012 17:34:23 +0100 5642299 http://www.medworm.com/index.php?rid=5642298&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.24695 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5642298 Mon, 30 Jan 2012 17:34:22 +0100 5642298 http://www.medworm.com/index.php?rid=5642288&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25630 Conclusion: Phospholipid and bile acid metabolism is disrupted in NASH, likely due to enhanced hepatic inflammatory signaling. Serum LPC and bile acids may be biomarkers of NASH. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5642288 Mon, 30 Jan 2012 17:29:32 +0100 5642288 http://www.medworm.com/index.php?rid=5642296&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25618 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5642296 Mon, 30 Jan 2012 05:00:00 +0100 5642296 http://www.medworm.com/index.php?rid=5642295&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25621 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5642295 Mon, 30 Jan 2012 05:00:00 +0100 5642295 http://www.medworm.com/index.php?rid=5642294&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25622 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5642294 Mon, 30 Jan 2012 05:00:00 +0100 5642294 http://www.medworm.com/index.php?rid=5642293&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25625 Conclusions: CB2 agonist alleviates portal hypertension, severity of portosystemic collaterals and mesenteric angiogenesis, intrahepatic angiogenesis and fibrosis in cirrhotic rats. The mechanism is, at least partly, through COX and NOS down‐regulation. Cannabinoids may be targeted in the control of portal hypertension and portosystemic collaterals. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5642293 Mon, 30 Jan 2012 05:00:00 +0100 5642293 http://www.medworm.com/index.php?rid=5642292&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25626 Conclusion: We propose a physiological function of serotonin is to ameliorate liver injury and stabilize the bile salt pool through adaptation of renal transporters in cholestatis. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5642292 Mon, 30 Jan 2012 05:00:00 +0100 5642292 http://www.medworm.com/index.php?rid=5642291&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25627 In conclusion, extrahepatic cholangiocarcinoma is often accompanied by the significant infiltration of IgG4‐positive cells. Cholangiocarcinoma cells could play the role of non‐professional APCs and Foxp3‐positive regulatory cells, inducing IgG4 reactions via the production of IL‐10 indirectly and directly, respectively. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5642291 Mon, 30 Jan 2012 05:00:00 +0100 5642291 http://www.medworm.com/index.php?rid=5642290&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25628 Conclusion: LVP are a mixed population of particles, comprising predominantly subviral particles that represent a distinct class of modified lipoproteins within the TRL family. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5642290 Mon, 30 Jan 2012 05:00:00 +0100 5642290 http://www.medworm.com/index.php?rid=5642289&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25629 Conclusion: Outcome following neoadjuvant chemoradiation and liver transplantation for perihilar CCA is excellent. Risk of dropout is related to patient and tumor characteristics and this can be used to guide patient counseling prior to enrolment. Recurrence risk is mostly associated with presence of residual cancer on explant. PSC patients do not have an independent survival advantage over de‐novo patients, but present with more favorable tumor characteristics. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5642289 Mon, 30 Jan 2012 05:00:00 +0100 5642289 http://www.medworm.com/index.php?rid=5633694&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25550 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5633694 Fri, 27 Jan 2012 14:20:54 +0100 5633694 http://www.medworm.com/index.php?rid=5633693&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.24718 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5633693 Fri, 27 Jan 2012 14:20:52 +0100 5633693 http://www.medworm.com/index.php?rid=5633692&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25525 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5633692 Fri, 27 Jan 2012 14:20:49 +0100 5633692 http://www.medworm.com/index.php?rid=5633689&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.24780 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5633689 Fri, 27 Jan 2012 14:20:43 +0100 5633689 http://www.medworm.com/index.php?rid=5633688&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.24713 Conclusion: There are strong functional, regulatory, and histopathological parallels between accelerated aging driven by a DNA repair defect and normal aging. This supports a role for DNA damage in driving aging and validates a murine model for rapidly testing hypotheses about causes and treatment for aging‐related hepatic changes. (HEPATOLOGY 2012) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5633688 Fri, 27 Jan 2012 14:20:37 +0100 5633688 http://www.medworm.com/index.php?rid=5633687&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.24701 Conclusion: OPN emerges as a key cytokine within the ECM protein network driving the increase in Collagen‐I protein contributing to scarring and liver fibrosis. (HEPATOLOGY 2012) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5633687 Fri, 27 Jan 2012 14:20:36 +0100 5633687 http://www.medworm.com/index.php?rid=5633686&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.24693 Conclusion: High ALDH activity is a feature of LPCs that can be taken advantage of to isolate these cells from untreated mouse as well as human liver tissues. This novel protocol is practically relevant, because it provides an easy and nontoxic method to isolate liver stem cells from normal tissue for potential therapeutic purposes. (HEPATOLOGY 2012) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5633686 Fri, 27 Jan 2012 14:20:30 +0100 5633686 http://www.medworm.com/index.php?rid=5633685&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.24748 Conclusion: These data suggest that depletion of B cells influences the induction, maintenance, and activation of both B and T cells and provides a potential mechanism for treatment of patients with PBC with an incomplete response to UDCA. (HEPATOLOGY 2012) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5633685 Fri, 27 Jan 2012 14:20:26 +0100 5633685 http://www.medworm.com/index.php?rid=5633684&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.24710 Conclusion: HCC survival is improving, because more cases are diagnosed and treated at early stages. Additional progress may be possible with continued use of clinical surveillance to follow individuals at risk for HCC, enabling early intervention. (HEPATOLOGY 2012;) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5633684 Fri, 27 Jan 2012 14:20:21 +0100 5633684 http://www.medworm.com/index.php?rid=5633683&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.24700 Conclusion: These results suggest that HCV promotes the accumulation of CD33+ MDSC, resulting in ROS‐mediated suppression of T‐cell responsiveness. Thus, the accumulation of MDSCs during HCV infection may facilitate and maintain HCV persistent infection. (HEPATOLOGY 2012) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5633683 Fri, 27 Jan 2012 14:20:06 +0100 5633683 http://www.medworm.com/index.php?rid=5633674&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25617 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5633674 Fri, 27 Jan 2012 14:15:36 +0100 5633674 http://www.medworm.com/index.php?rid=5633682&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25616 Conclusion:LS predicts the development of hepatic decompensations and liver‐related mortality in HIV/HCV‐coinfected with compensated cirrhosis and provides additional prognostic information to that provided by CTP score. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5633682 Wed, 25 Jan 2012 05:00:00 +0100 5633682 http://www.medworm.com/index.php?rid=5633681&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25609 AbstractThe nuclear bile acid receptor, Farnesoid X Receptor (FXR), is an important transcriptional regulator of liver metabolism. Despite recent advances in understanding its functions, how FXR regulates genomic targets and whether the transcriptional regulation by FXR is altered in obesity remain largely unknown. Here, we analyzed hepatic genome‐wide binding sites of FXR in normal and dietary obese mice by chromatin immunoprecipitation‐sequencing (ChIP‐seq) analysis. A total of 15,263 and 5,272 FXR binding sites were identified in livers of normal and obese mice, respectively, after a short one hour treatment with the synthetic FXR agonist, GW4064. Of these sites, 7,440 and 2,344 were detected uniquely in normal and obese mice. FXR binding sites were localized mostly in intergenic ... Hepatology journals http://www.medworm.com/rss/comments.php?id=5633681 Wed, 25 Jan 2012 05:00:00 +0100 5633681 http://www.medworm.com/index.php?rid=5633680&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25610 Conclusion:MRE is more reliable for staging hepatic fibrosis compared with DWI with a high combination of sensitivity, specificity, likelihood ratios, DOR, and area under sROC curve. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5633680 Wed, 25 Jan 2012 05:00:00 +0100 5633680 http://www.medworm.com/index.php?rid=5633679&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25611 Conclusion:Cidea plays critical roles in promoting hepatic lipid accumulation and in the development of hepatic steatosis by acting as a sensor that responds to diets that contain fatty acids. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5633679 Wed, 25 Jan 2012 05:00:00 +0100 5633679 http://www.medworm.com/index.php?rid=5633678&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25612 AbstractLiver failure due to chronic hepatitis C virus infection is a major cause for liver transplantation worldwide. Recurrent infection of the graft is universal in HCV patients following transplant and results in rapid progression to severe fibrosis and end‐stage liver disease in one‐third of all patients. No single clinical variable, or combination thereof, has so far proven accurate in identifying patients at risk of hepatic decompensation in the transplant setting. A combination of longitudinal, dimensionality reduction, and categorical analysis of the transcriptome from 111 liver biopsy specimens taken from 57 HCV‐infected patients over time identified a molecular signature of gene expression of patients at risk of developing severe fibrosis. Significantly, alterations in gen... Hepatology journals http://www.medworm.com/rss/comments.php?id=5633678 Wed, 25 Jan 2012 05:00:00 +0100 5633678 http://www.medworm.com/index.php?rid=5633677&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25613 Conclusions:miR 19b is a novel regulator of TGFβ signaling in HSCs suggesting a potential therapeutic approach for hepatic fibrosis. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5633677 Wed, 25 Jan 2012 05:00:00 +0100 5633677 http://www.medworm.com/index.php?rid=5633676&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25614 Conclusion:LPC markers correlate positively with severity of liver disease and short‐term mortality in AH patients. This study suggests that LPC proliferation may be an important feature of AH pathophysiology. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5633676 Wed, 25 Jan 2012 05:00:00 +0100 5633676 http://www.medworm.com/index.php?rid=5633675&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25615 Conclusion:HGF and EGF suppress hepatic hepcidin synthesis, in part through PI3 kinase MEK/ERK kinase pathways which may be modulating the nuclear localization of BMP pathway transcriptional regulators including activated Smads1/5/8 and the co‐repressor TGIF. EGF, HGF and possibly other growth factors that activate similar pathways may contribute to hepcidin suppression in chronic liver diseases, promote iron accumulation in the liver and exacerbate the destructive disease processes. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5633675 Wed, 25 Jan 2012 05:00:00 +0100 5633675 http://www.medworm.com/index.php?rid=5623630&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25594 Conclusion:We have identified PPARγ as a negative regulator of MAT2A in quiescent HSCs. A switch from quiescence to activation state abolishes this control and allows PPARβ to up‐regulate MAT2A transcription. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5623630 Mon, 23 Jan 2012 05:00:00 +0100 5623630 http://www.medworm.com/index.php?rid=5623629&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25597 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5623629 Mon, 23 Jan 2012 05:00:00 +0100 5623629 http://www.medworm.com/index.php?rid=5623628&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25598 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5623628 Mon, 23 Jan 2012 05:00:00 +0100 5623628 http://www.medworm.com/index.php?rid=5623627&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25599 Conclusion:TE is one of the best current surrogate markers of liver fibrosis in PBC. Over a 5‐year period, on‐treatment liver stiffness appears stable in most non‐cirrhotic PBC patients, while it significantly increases in patients with cirrhosis. Progression of LSM in PBC is predictive of poor outcome. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5623627 Mon, 23 Jan 2012 05:00:00 +0100 5623627 http://www.medworm.com/index.php?rid=5623626&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25603 Conclusion:The proposed model, with the allocation of deMELD, has the potential to allow for a dynamic and combined comparison of opportunities to receive a graft for HCC and non‐HCC patients on a common waiting list. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5623626 Mon, 23 Jan 2012 05:00:00 +0100 5623626 http://www.medworm.com/index.php?rid=5623625&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25601 Conclusions:Lack of ATGL may protect from hepatic ER stress via alterations in FA composition. ATGL could constitute a new therapeutic strategy to target ER stress in NAFLD. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5623625 Mon, 23 Jan 2012 05:00:00 +0100 5623625 http://www.medworm.com/index.php?rid=5623624&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25600 Conclusions: The present results indicate that activation of the AKT/mTOR cascade by unconstrained insulin signaling induces a defined module of metabolic alterations in hepatocytes contributing to aberrant cell growth. Thus, inhibition of AKT/mTOR and related metabolic changes might represent a novel preventive and therapeutic approach to effectively inhibit insulin‐induced hepatocarcinogenesis. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5623624 Mon, 23 Jan 2012 05:00:00 +0100 5623624 http://www.medworm.com/index.php?rid=5623623&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25596 Conclusions:Cyclin G1 plays a pivotal role in HCC metastasis and may serve as a novel prognostic biomarker and therapeutic target. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5623623 Mon, 23 Jan 2012 05:00:00 +0100 5623623 http://www.medworm.com/index.php?rid=5623622&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25595 Conclusion:Muc‐ICCs had a similar clinicopathological, immunohistochemical, and molecular profile to hilar CCs (from mucin‐producing cholangiocytes), while mixed‐ICCs had a similar profile to CLCs (thought to be of HPC origin), possibly reflecting their respective cells of origin. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5623622 Mon, 23 Jan 2012 05:00:00 +0100 5623622 http://www.medworm.com/index.php?rid=5623621&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25593 CONCLUSIONS:Patients with NAFLD are at increased risk for coronary atherosclerosis independent of classical coronary risk factors, including visceral adiposity. These data suggest that NAFLD per se might be an independent risk factor for coronary artery disease. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5623621 Mon, 23 Jan 2012 05:00:00 +0100 5623621 http://www.medworm.com/index.php?rid=5623620&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25602 In conclusion, our data indicate that ‐ in contrast to their reported inhibitory effects on other viruses ‐ both leflunomide and FK778 can augment HBV replication. Treatment with leflunomide, FK778, or MPA may bear the risk to enhance HBV replication in infected patients. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5623620 Mon, 23 Jan 2012 05:00:00 +0100 5623620 http://www.medworm.com/index.php?rid=5623619&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25592 Conclusions.In patients infected with preS/S variants, HBV DNA replication and HBsAg synthesis/secretion appear to be dissociated. Therefore, the use of HBsAg titer as diagnostic/prognostic tool has to take into account the frequent emergence of preS/S variants in chronic HBV infection. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5623619 Mon, 23 Jan 2012 05:00:00 +0100 5623619 http://www.medworm.com/index.php?rid=5623618&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25604 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5623618 Mon, 23 Jan 2012 05:00:00 +0100 5623618 http://www.medworm.com/index.php?rid=5623617&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25606 Conclusion:Cirrhosis regression and fibrosis amount decrease are frequently observed among HCV cirrhotic patients with an SVR. Despite ductular proliferation vanishing and lobular zonation restoration, portal inflammation and sinusoidal capillarization may not regress after viral eradication. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5623617 Mon, 23 Jan 2012 05:00:00 +0100 5623617 http://www.medworm.com/index.php?rid=5623616&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25607 Conclusion:In the present study, we demonstrated that HEC‐selective and efficient ICAM‐1 siRNA delivery using Man‐PEG2000 BLs and US exposure enables to suppress various types of acute hepatic inflammation. This novel siRNA delivery method may offer a valuable system for medical treatment where the targeted cells are HECs. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5623616 Mon, 23 Jan 2012 05:00:00 +0100 5623616 http://www.medworm.com/index.php?rid=5615376&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25584 In this report, we examined the potential role of the candidate amplified oncogene SGK3 at 8q13.1 in HCC pathogenesis. We found amplification and overexpression of SGK3 was frequently detected in clinical HCC specimens and that SGK3 genomic activation was significantly associated with poor outcome of patients (P=0.028). Functionally, we found that overexpression of SGK3 in HCC cells increased cell cycle progression through G1, cell survival, clonogenicity, anchorage‐independent growth, and tumor formation in nude mice. In contrast, RNAi silencing of SGK3 inhibited its oncogenic effects. We provide evidences that SGK3 promotes HCC growth and survival through inactivating GSK3‐β and BAD respectively. We also find that expression of SGK3, which like AKT is activated by PI3K/PDK1 signalin... Hepatology journals http://www.medworm.com/rss/comments.php?id=5615376 Thu, 19 Jan 2012 05:00:00 +0100 5615376 http://www.medworm.com/index.php?rid=5615375&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25585 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5615375 Thu, 19 Jan 2012 05:00:00 +0100 5615375 http://www.medworm.com/index.php?rid=5615374&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25586 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5615374 Thu, 19 Jan 2012 05:00:00 +0100 5615374 http://www.medworm.com/index.php?rid=5615373&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25587 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5615373 Thu, 19 Jan 2012 05:00:00 +0100 5615373 http://www.medworm.com/index.php?rid=5615372&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25588 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5615372 Thu, 19 Jan 2012 05:00:00 +0100 5615372 http://www.medworm.com/index.php?rid=5615371&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25589 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5615371 Thu, 19 Jan 2012 05:00:00 +0100 5615371 http://www.medworm.com/index.php?rid=5615370&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25591 Conclusion: AP2 mediates the internalization and subsequent degradation of CM‐resident BSEP through direct interaction with BSEP, and thereby modulates the canalicular expression and transport function of BSEP. This information should be useful for understanding the pathogenesis of severe liver diseases associated with intrahepatic cholestasis. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5615370 Thu, 19 Jan 2012 05:00:00 +0100 5615370 http://www.medworm.com/index.php?rid=5590742&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25568 Conclusion: Rnd3 down‐regulation provides an invasive advantage to tumor hepatocytes suggesting that RND3 might represent a metastasis suppressor gene in hepatocellular carcinoma. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5590742 Wed, 11 Jan 2012 05:00:00 +0100 5590742 http://www.medworm.com/index.php?rid=5590741&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25569 AbstractAlterations in DNA methylation frequently occur in hepatocellular cancer (HCC). We have previously demonstrated that hypermethylation in candidate genes can be detected in plasma DNA prior to HCC diagnosis. To identify with a genome‐wide approach additional genes hypermethylated in HCC that could be used for more accurate analysis of plasma DNA for early diagnosis, we analyzed tumor and adjacent non‐tumor tissues from 62 Taiwanese HCC cases using Illumina methylation arrays that screen 26,486 autosomal CpG sites. After Bonferroni adjustment, a total of 2,324 CpG sites significantly differed in methylation level, with 684 CpG sites significantly hypermethylated and 1,640 hypomethylated in tumor compared to non‐tumor tissues. Array data were validated with pyrosequencing in a s... Hepatology journals http://www.medworm.com/rss/comments.php?id=5590741 Wed, 11 Jan 2012 05:00:00 +0100 5590741 http://www.medworm.com/index.php?rid=5590740&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25570 Conclusion: We suggest that the fibrous stromal component in HCC may contribute to the acquisition of CC‐like gene expression traits in HCC. The expression of stem cell‐like traits and TGF‐β/EMT molecules may play a pivotal role in the aggressive phenotyping of S‐HCC. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5590740 Wed, 11 Jan 2012 05:00:00 +0100 5590740 http://www.medworm.com/index.php?rid=5590739&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25571 Conclusion: These data firmly establish an endogenous role for AHR as a regulator of the cholesterol biosynthesis pathway independent of its DRE‐binding ability and suggest that AHR may be a previously unrecognized therapeutic target. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5590739 Wed, 11 Jan 2012 05:00:00 +0100 5590739 http://www.medworm.com/index.php?rid=5590738&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25572 Conclusion: These results suggest that in hypoxic HCC cells, HMGB1 activates TLR4 and RAGE signaling pathways to induce caspase‐1 activation with subsequent production of multiple inflammatory mediators which in turn promotes cancer invasion and metastasis. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5590738 Wed, 11 Jan 2012 05:00:00 +0100 5590738 http://www.medworm.com/index.php?rid=5590737&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25573 AbstractIn patients with cirrhosis adrenal insufficiency (AI) is reported during sepsis and septic shock, and is associated with increased mortality. Consequently, the term “hepato‐adrenal syndrome” was proposed. Some studies have shown that AI is frequent in stable cirrhosis, and in cirrhosis associated with decompensation other than sepsis, such as bleeding and ascites. Moreover, other studies showed a high prevalence in liver transplant recipients, immediately after or some time after liver transplantation. The effect of corticosteroid therapy in critically ill patients with liver disease has been evaluated in some studies, but the results remain controversial.The 250 µg ACTH stimulation test to diagnose AI in critically ill adult patients is recommended by an international task ... Hepatology journals http://www.medworm.com/rss/comments.php?id=5590737 Wed, 11 Jan 2012 05:00:00 +0100 5590737 http://www.medworm.com/index.php?rid=5590736&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25575 Conclusions:Spontaneous clearance of acute HCV infection is predicted by high initial viremia as well as favorable IL‐28B genotype, and associated with rapid envelope sequence evolution. This linkage of host genetics, viral dynamics, and evolution provides new directions for mechanistic studies. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5590736 Wed, 11 Jan 2012 05:00:00 +0100 5590736 http://www.medworm.com/index.php?rid=5590735&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25578 AbstractNo absract. (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5590735 Wed, 11 Jan 2012 05:00:00 +0100 5590735 http://www.medworm.com/index.php?rid=5590734&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25579 Conclusions:Tacrolimus to sirolimus conversion increases systemic Tregs, DCregs and immunoregulatory proteogenomic signatures in liver transplant recipients and may therefore facilitate immunosuppression minimization or withdrawal. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5590734 Wed, 11 Jan 2012 05:00:00 +0100 5590734 http://www.medworm.com/index.php?rid=5590733&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25583 AbstractNo absract. (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5590733 Wed, 11 Jan 2012 05:00:00 +0100 5590733 http://www.medworm.com/index.php?rid=5590732&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25582 Conclusion: Treatment outcome prediction could not be improved in homozygous carriers of the IL28B rs12979860 C responder allele by the additional determination of the rs8099917 SNPs. There is evidence that a significant proportion of heterozygous carriers of the rs12979860 T non‐responder allele can profit with respect to SVR prediction by further determination of the rs8099917 SNPs. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5590732 Wed, 11 Jan 2012 05:00:00 +0100 5590732 http://www.medworm.com/index.php?rid=5590731&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25581 AbstractThe influence of naturally occurring polymorphisms on the potency of the HCV NS5A replication complex inhibitor BMS‐790052 was investigated by evaluating hybrid replicons in which the entire NS5A coding region of genotype (GT) la and 1b laboratory (lab) strains (H77c and Con1) were replaced with the corresponding regions of specimens collected from ten GT‐1a and six GT‐1b infected subjects. For baseline (BL) specimens, with no previously observed resistance variants indentified by population sequencing, the EC50 values for BMS‐790052 were similar for the clinically‐derived and lab strains. A Q30R variant was observed at viral breakthrough (VBT) in one of the GT‐1a infected subjects. Since the lowest plasma exposure of BMS‐790052 observed in this subject was 117 nM and... Hepatology journals http://www.medworm.com/rss/comments.php?id=5590731 Wed, 11 Jan 2012 05:00:00 +0100 5590731 http://www.medworm.com/index.php?rid=5590730&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25580 CONCLUSIONSDespite extensive metabolic derangements in T2DM mice, inhibition of a single dysregulated molecule, SULF2, normalizes the VLDL‐binding capacity of their hepatocytes and abolishes postprandial hypertriglyceridemia. These findings provide a key proof‐of‐concept in vivo to support Sulf2 inhibition as an attractive strategy to improve metabolic dyslipidemia. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5590730 Wed, 11 Jan 2012 05:00:00 +0100 5590730 http://www.medworm.com/index.php?rid=5590729&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25576 Conclusion: These findings indicate that miR‐7 functions as a tumor suppressor and plays a substantial role in inhibiting the tumorigenesis and reversing the metastasis of HCC through the PI3K/Akt/mTOR signaling pathway in vitro and in vivo. By targeting PIK3CD, mTOR and p70S6K, miR‐7 efficiently regulates the PI3K/Akt pathway. Given these, miR‐7 may be a potential therapeutic or diagnostic/prognostic‐target for treating HCC. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5590729 Wed, 11 Jan 2012 05:00:00 +0100 5590729 http://www.medworm.com/index.php?rid=5590728&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25574 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5590728 Wed, 11 Jan 2012 05:00:00 +0100 5590728 http://www.medworm.com/index.php?rid=5623615&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25608 Conclusion:MxA displays antiviral activity against HBV involving a mechanism of MxA‐HBcAg interaction which may interfere with core particle formation. (HEPATOLOGY 2012.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5623615 Sun, 01 Jan 2012 05:00:00 +0100 5623615 http://www.medworm.com/index.php?rid=5615369&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25590 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5615369 Sun, 01 Jan 2012 05:00:00 +0100 5615369 http://www.medworm.com/index.php?rid=5590727&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25545 In conclusion, the results identify direct angiostatic and anti‐fibrotic effects of the Cxcr3 ligand Cxcl9 in a model of experimental liver fibrosis. The amelioration of liver damage by systemic application of Cxcl9 might offer a novel therapeutic approach for chronic liver diseases associated with increased neoangiogenesis. (HEPATOLOGY 2011.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5590727 Sun, 01 Jan 2012 05:00:00 +0100 5590727 http://www.medworm.com/index.php?rid=5566973&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25577 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5566973 Sun, 01 Jan 2012 05:00:00 +0100 5566973 http://www.medworm.com/index.php?rid=5548637&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25558 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5548637 Thu, 29 Dec 2011 06:37:46 +0100 5548637 http://www.medworm.com/index.php?rid=5548654&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25567 Conclusions:Elastin is regulated at the level of degradation during liver fibrosis. Macrophage derived MMP‐12 regulates elastin degradation even in progressive experimental liver fibrosis. These observations have important implications for the design of antifibrotic therapies. (HEPATOLOGY 2011.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5548654 Tue, 27 Dec 2011 05:00:00 +0100 5548654 http://www.medworm.com/index.php?rid=5548653&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25566 Conclusion: These findings suggest that combination therapy with both enzyme inhibitors may be a strategy for therapy of sensitive HCC cells, and identification of these novel molecular determinants may eventually guide the optimal use of PARP and HDAC inhibitors in the clinic. (HEPATOLOGY 2011.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5548653 Tue, 27 Dec 2011 05:00:00 +0100 5548653 http://www.medworm.com/index.php?rid=5548652&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25565 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5548652 Tue, 27 Dec 2011 05:00:00 +0100 5548652 http://www.medworm.com/index.php?rid=5548651&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25564 Conclusion: ZNF191 can directly bind to CTNNB1 promoter, and activate the expression of β‐Catenin and its downstream target genes such as Cyclin D1 in hepatoma cell lines. This study uncovers a new molecular mechanism of transcription regulation of β‐Catenin gene in HCC. (HEPATOLOGY 2011.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5548651 Tue, 27 Dec 2011 05:00:00 +0100 5548651 http://www.medworm.com/index.php?rid=5548650&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25563 Conclusions: Individuals predisposed to GSD display increased biliary output of cholesterol in the setting of relatively low intestinal cholesterol absorption, indicating enhanced whole body sterol clearance. This metabolic trait precedes gallstone formation and is a feature of ethnic groups at higher risk of cholesterol GSD. (HEPATOLOGY 2011.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5548650 Tue, 27 Dec 2011 05:00:00 +0100 5548650 http://www.medworm.com/index.php?rid=5548649&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25561 Conclusion:Our data redefine the genetic basis behind GS. In vivo data studying the genotype present in 76% of GS individuals suggest that transcription and transcriptional activation of glucuronidation genes responsible for conjugation and detoxification is directly affected leading to lower responsiveness. This study suggests that GS should be considered as a potential risk factor for drug toxicity. (HEPATOLOGY 2011.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5548649 Tue, 27 Dec 2011 05:00:00 +0100 5548649 http://www.medworm.com/index.php?rid=5548648&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25562 Conclusion: MPA exerts a potent anti‐HCV effect in vitro and in mice and acts in synergy with IFN‐α. MPA's anti‐viral activity partially depends on IMPDH but also involves stimulation of ISGs, providing a molecular basis for it's synergy with IFN‐α. (HEPATOLOGY 2011.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5548648 Tue, 27 Dec 2011 05:00:00 +0100 5548648 http://www.medworm.com/index.php?rid=5548647&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25560 Conclusion: SNX7 is a liver‐enriched anti‐apoptotic protein which is indispensable for the survival of hepatoblasts during zebrafish early embryogenesis. (HEPATOLOGY 2011.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5548647 Tue, 27 Dec 2011 05:00:00 +0100 5548647 http://www.medworm.com/index.php?rid=5548646&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25559 Conclusion:In NAFLD patients, the level of hepatic HH pathway activity is highly correlated with the severity of liver damage and with metabolic syndrome parameters that are known to be predictive of advanced liver disease. Hence, deregulation of the HH signaling network may contribute to the pathogenesis and sequelae of liver damage that develops with the metabolic syndrome. (HEPATOLOGY 2011.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5548646 Tue, 27 Dec 2011 05:00:00 +0100 5548646 http://www.medworm.com/index.php?rid=5548645&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25557 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5548645 Tue, 27 Dec 2011 05:00:00 +0100 5548645 http://www.medworm.com/index.php?rid=5548644&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25556 Conclusion:These data indicate that fewer than half of those infected with HCV may be aware of their infection. The findings suggest that more intensive efforts are needed to identify and test persons at risk for HCV infection. (HEPATOLOGY 2011.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5548644 Tue, 27 Dec 2011 05:00:00 +0100 5548644 http://www.medworm.com/index.php?rid=5548643&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25554 Conclusion: An abnormal PHES identifies patients with cirrhosis at risk for falls. This psychometric test may be useful to promote awareness of falls and identify patients who may benefit from preventive strategies. (HEPATOLOGY 2011.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5548643 Tue, 27 Dec 2011 05:00:00 +0100 5548643 http://www.medworm.com/index.php?rid=5548642&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25552 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5548642 Tue, 27 Dec 2011 05:00:00 +0100 5548642 http://www.medworm.com/index.php?rid=5548641&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25553 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5548641 Tue, 27 Dec 2011 05:00:00 +0100 5548641 http://www.medworm.com/index.php?rid=5548640&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25551 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5548640 Tue, 27 Dec 2011 05:00:00 +0100 5548640 http://www.medworm.com/index.php?rid=5548639&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25550 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5548639 Tue, 27 Dec 2011 05:00:00 +0100 5548639 http://www.medworm.com/index.php?rid=5548638&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25549 Conclusion:AIB1 plays an important role in proliferation and chemoresistance of CCA through simultaneous activation of Akt and Nrf2 pathways, suggesting that AIB1 is a potential molecular target for CCA treatment. (HEPATOLOGY 2011.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5548638 Tue, 27 Dec 2011 05:00:00 +0100 5548638 http://www.medworm.com/index.php?rid=5541519&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25548 Conclusions:Following the Department of Health and Human Services recommended physical activity guidelines has small but beneficial effects on IHTG content, but does not improve hepatic lipoprotein kinetics, in obese persons with NAFLD. (HEPATOLOGY 2011.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5541519 Mon, 26 Dec 2011 02:23:48 +0100 5541519 http://www.medworm.com/index.php?rid=5541524&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25542 Conclusions:Gal‐3 plays an important pro‐inflammatory role in Con A induced hepatitis by promoting activation of T lymphocytes, NKT cells and maturation of DCs, secretion of proinflammatory cytokines and down‐regulating M2 macrophage polarization and apoptosis of MNCs in the liver. (HEPATOLOGY 2011.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5541524 Sat, 24 Dec 2011 05:00:00 +0100 5541524 http://www.medworm.com/index.php?rid=5541523&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25543 Conclusion:Partial Ass ablation protects only in acute ethanol‐induced liver injury by decreasing nitrosative stress but not in a more chronic scenario where oxidative stress and impaired fatty acid β‐oxidation are key events. (HEPATOLOGY 2011.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5541523 Sat, 24 Dec 2011 05:00:00 +0100 5541523 http://www.medworm.com/index.php?rid=5541522&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25544 Conclusions:Compared with alcoholic cirrhosis, patients with alcoholic hepatitis have similar post transplantation graft and patient survival. Based on these preliminary findings, liver transplantation may be considered in a select group of patients with alcoholic hepatitis who fail to improve with medical therapy. Prospective studies are needed to assess the long‐term outcome after liver transplantation in patients with alcoholic hepatitis. (HEPATOLOGY 2011.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5541522 Sat, 24 Dec 2011 05:00:00 +0100 5541522 http://www.medworm.com/index.php?rid=5541521&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25546 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5541521 Sat, 24 Dec 2011 05:00:00 +0100 5541521 http://www.medworm.com/index.php?rid=5541520&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25547 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5541520 Sat, 24 Dec 2011 05:00:00 +0100 5541520 http://www.medworm.com/index.php?rid=5531187&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.24677 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5531187 Fri, 23 Dec 2011 03:05:06 +0100 5531187 http://www.medworm.com/index.php?rid=5531186&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.24659 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5531186 Fri, 23 Dec 2011 03:05:05 +0100 5531186 http://www.medworm.com/index.php?rid=5531185&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.24627 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5531185 Fri, 23 Dec 2011 03:05:04 +0100 5531185 http://www.medworm.com/index.php?rid=5531184&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.24742 AbstractThe human gene PTPN11, which encodes the tyrosine phosphatase Shp2, may act as a proto‐oncogene because dominantly activating mutations have been detected in several types of leukemia. Herein we report a tumor‐suppressor function of Shp2. Hepatocyte‐specific deletion of Shp2 promotes inflammatory signaling through the Stat3 pathway and hepatic inflammation/necrosis, resulting in regenerative hyperplasia and development of tumors in aged mice. Furthermore, Shp2 ablation dramatically enhanced diethylnitrosamine (DEN)‐induced hepatocellular carcinoma (HCC) development, which was abolished by concurrent deletion of Shp2 and Stat3 in hepatocytes. Decreased Shp2 expression was detected in a subfraction of human HCC specimens. Thus, in contrast to the leukemogenic effect of domina... Hepatology journals http://www.medworm.com/rss/comments.php?id=5531184 Fri, 23 Dec 2011 03:05:02 +0100 5531184 http://www.medworm.com/index.php?rid=5531183&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.24727 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5531183 Fri, 23 Dec 2011 03:05:01 +0100 5531183 http://www.medworm.com/index.php?rid=5531182&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.24717 AbstractThe generation of functional hepatocytes independent of donor liver organs is of great therapeutic interest with regard to regenerative medicine and possible cures for liver disease. Induced hepatic differentiation has been achieved previously using embryonic stem cells or induced pluripotent stem cells. Particularly, hepatocytes generated from a patient's own induced pluripotent stem cells could theoretically avoid immunological rejection. However, the induction of hepatocytes from induced pluripotent stem cells is a complicated process that would probably be replaced with the arrival of improved technology. Overexpression of lineage‐specific transcription factors directly converts terminally differentiated cells into some other lineages, including neurons, cardiomyocytes and bl... Hepatology journals http://www.medworm.com/rss/comments.php?id=5531182 Fri, 23 Dec 2011 03:05:00 +0100 5531182 http://www.medworm.com/index.php?rid=5531181&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.24797 AbstractThe 2010 Institute of Medicine report on “Hepatitis and Liver Cancer” indicated that lack of knowledge and awareness about chronic hepatitis B (HBV) and C virus (HCV) infections and insufficient understanding about the extent and seriousness of this public health problem impeded current efforts to prevent and control hepatitis B and C. A single‐topic conference was held in June 2011 to discuss strategies to improve the effectiveness of screening, care referral, and clinical management of chronic HBV and HCV infections with the ultimate goal of reducing morbidity and mortality from these infections. Various models that have been shown to improve hepatitis screening and effectiveness of hepatitis treatment in the community, including rural settings and populations that have tra... Hepatology journals http://www.medworm.com/rss/comments.php?id=5531181 Fri, 23 Dec 2011 03:04:59 +0100 5531181 http://www.medworm.com/index.php?rid=5531180&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.24625 Conclusion: Using primary human liver cells, we identified a novel mechanism of rAAV recognition in the liver, demonstrating that alternative means of sensing rAAV particles have evolved. Minimizing this recognition will be key to improving rAAV‐mediated gene transfer and reducing side effects in clinical trials due to immune responses against rAAV. (Hepatology 2012;55:287–297) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5531180 Fri, 23 Dec 2011 03:04:57 +0100 5531180 http://www.medworm.com/index.php?rid=5531179&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.24655 Conclusion: Glucocorticoids interfere with IL‐6–induced expression of the feedback inhibitor SOCS3, thereby leading to enhanced expression of acute‐phase genes in hepatocytes. This mechanism contributes to the explanation of how glucocorticoids affect inflammation and acute‐phase gene induction. (HEPATOLOGY 2012;55:256–266) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5531179 Fri, 23 Dec 2011 03:04:53 +0100 5531179 http://www.medworm.com/index.php?rid=5531178&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.24621 Conclusion: Taken together, these results suggest that DCs increase fibrosis regression and that the effect is correlated with their production of MMP‐9. The results also suggest that Flt3L treatment during fibrosis resolution merits evaluation to accelerate regression of advanced liver fibrosis. (HEPATOLOGY 2012;55:243–255) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5531178 Fri, 23 Dec 2011 03:04:52 +0100 5531178 http://www.medworm.com/index.php?rid=5531177&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.24673 Conclusion: Our data suggest that altered expression of SCF+GM‐CSF after PH can contribute to biliary remodeling (e.g., post‐transplantation) by functional deregulation of the activity of key signaling intermediates involved in cell expansion and multipotent differentiation. (HEPATOLOGY 2012;;55:209–221) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5531177 Fri, 23 Dec 2011 03:04:48 +0100 5531177 http://www.medworm.com/index.php?rid=5531176&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.24652 Conclusion: These findings indicate that sunitinib inhibits HCC tumor growth directly through the STAT3 pathway and prevents tumor antigen‐specific CD8+ T‐cell tolerance, thus defining a synergistic chemoimmunotherapeutic approach for HCC. (HEPATOLOGY 2012;55:141–152) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5531176 Fri, 23 Dec 2011 03:04:40 +0100 5531176 http://www.medworm.com/index.php?rid=5531175&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.24680 Conclusion: The high risk of failure of ST after initial LR for HCC within MC suggests the use of tissue analysis as a selection criterion. The salvage LT strategy should be restricted to patients with favorable oncological factors. (HEPATOLOGY 2012;;55:132–140) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5531175 Fri, 23 Dec 2011 03:04:39 +0100 5531175 http://www.medworm.com/index.php?rid=5531174&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.24629 Conclusion: These findings suggest that immunization with ASPH‐loaded DCs may constitute a novel therapeutic approach for intrahepatic cholangiocarcinoma, because this protein also appears to be highly conserved and expressed on human hepatobiliary tumors. (HEPATOLOGY 2012;55:86–97) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5531174 Fri, 23 Dec 2011 03:04:35 +0100 5531174 http://www.medworm.com/index.php?rid=5531173&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.24615 Conclusion: In HBeAg‐negative patients with HBV genotype B or C infection who have HBV DNA level <2000 IU/mL, HBsAg level <10 IU/mL is the strongest predictor of HBsAg loss. (HEPATOLOGY 2012;55:68–76) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5531173 Fri, 23 Dec 2011 03:04:32 +0100 5531173 http://www.medworm.com/index.php?rid=5531172&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.24654 Conclusion: SAFE and BA for significant fibrosis or cirrhosis are very accurate. However, their successive use induces a significant decrease in diagnostic accuracy and a significant increase in required liver biopsy. A new fibrosis classification that synchronously combines two fibrosis tests was as accurate as successive SAFE or BA, while providing an entirely noninvasive (0% liver biopsy) and more precise (six versus two or three fibrosis classes) fibrosis diagnosis. (HEPATOLOGY 2012;55:58–67) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5531172 Fri, 23 Dec 2011 03:04:31 +0100 5531172 http://www.medworm.com/index.php?rid=5531155&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25541 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5531155 Fri, 23 Dec 2011 03:01:24 +0100 5531155 http://www.medworm.com/index.php?rid=5642297&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25533 Conclusion: These results support the hypothesis that the NS5A/HSP70 complex augments viral IRES‐mediated translation, identify a sequence‐specific hairpin element in NS5A responsible for complex formation, and demonstrate the functional significance of C34 hairpin–mediated NS5A/HSP70 interaction. Identification of this element may allow for further interrogation of NS5A‐mediated IRES activity, sequence‐specific HSP recognition, and rational drug design. (HEPATOLOGY 2012) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5642297 Tue, 20 Dec 2011 05:00:00 +0100 5642297 http://www.medworm.com/index.php?rid=5531169&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25529 Conclusion: We found that RORα induced the activation of AMPK and the inhibition of the lipogenic function of LXRα, which may be key phenomena that provide beneficial effects of RORα against hepatic steatosis. (HEPATOLOGY 2011.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5531169 Tue, 20 Dec 2011 05:00:00 +0100 5531169 http://www.medworm.com/index.php?rid=5531168&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25530 Conclusions: HEV inhibits IFN‐α signaling through the regulation of STAT1 phosphorylation in A549 cells. These findings have implications for the development of new strategies against hepatitis E. (HEPATOLOGY 2011.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5531168 Tue, 20 Dec 2011 05:00:00 +0100 5531168 http://www.medworm.com/index.php?rid=5531167&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25531 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5531167 Tue, 20 Dec 2011 05:00:00 +0100 5531167 http://www.medworm.com/index.php?rid=5531165&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25532 Conclusions:Multiresistant bacteria, especially ESBL‐producing Enterobacteriaceae, are frequently isolated in nosocomial and to a lesser extent health care‐associated infections in cirrhosis, rendering third‐generation cephalosporins clinically ineffective. New antibiotic strategies tailored according to the local epidemiological patterns are needed for the empirical treatment of nosocomial infections in cirrhosis. (HEPATOLOGY 2011.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5531165 Tue, 20 Dec 2011 05:00:00 +0100 5531165 http://www.medworm.com/index.php?rid=5531164&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25533 Conclusion: These results support the hypothesis that the NS5A/HSP70 complex augments viral IRES‐mediated translation, identify a sequence‐specific hairpin element in NS5A responsible for complex formation, and demonstrate the functional significance of C34 hairpin‐mediated NS5A/HSP70 interaction. Identification of this element may allow for further interrogation of NS5Amediated IRES activity, sequence specific HSP recognition, and rational drug design. (HEPATOLOGY 2011.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5531164 Tue, 20 Dec 2011 05:00:00 +0100 5531164 http://www.medworm.com/index.php?rid=5531163&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25534 Conclusion:A HF/MCD diet and hyperleptinaemia increase hepatic endocannabinoids production, promote hepatic fibrogenesis, enhanced the hepatic vasoconstrictive response to endothelin‐1 and aggravate hepatic microcirculatory dysfunction, these events subsequently increased IHR and portal hypertension in NASH‐cirrhotic rats. (HEPATOLOGY 2011.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5531163 Tue, 20 Dec 2011 05:00:00 +0100 5531163 http://www.medworm.com/index.php?rid=5531162&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25535 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5531162 Tue, 20 Dec 2011 05:00:00 +0100 5531162 http://www.medworm.com/index.php?rid=5531161&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25536 Conclusions:Patients with HCC in the setting of NASH have less severe liver dysfunction at HCC diagnosis and better overall survival after curative treatment compared to counterparts with HCV and/or alcoholic liver disease. (HEPATOLOGY 2011.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5531161 Tue, 20 Dec 2011 05:00:00 +0100 5531161 http://www.medworm.com/index.php?rid=5531160&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25537 Conclusion:Our findings suggest that S6K2 regulates hepatic energy homeostasis by repressing PPARa activity, and point to its potential relevance for therapeutic strategies designed to modulate S6K2 activity as a treatment for deregulated ketone body production. (HEPATOLOGY 2011.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5531160 Tue, 20 Dec 2011 05:00:00 +0100 5531160 http://www.medworm.com/index.php?rid=5531159&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25538 Conclusions:Patients with hyperferritinemia are more likely to be C282Y homozygotes if they have normal liver transaminase activities. This paradox could explain the low yields of hemochromatosis screening reported by some liver clinics. (HEPATOLOGY 2011.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5531159 Tue, 20 Dec 2011 05:00:00 +0100 5531159 http://www.medworm.com/index.php?rid=5531158&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25539 Conclusion:adipose tissue insulin resistance plays a key role in the development of metabolic and histological abnormalities of obese patients with NAFLD. Treatment strategies targeting adipose tissue insulin resistance (weight loss, thiazolidinediones) may be of value in this population. (HEPATOLOGY 2011.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5531158 Tue, 20 Dec 2011 05:00:00 +0100 5531158 http://www.medworm.com/index.php?rid=5531156&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25540 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5531156 Tue, 20 Dec 2011 05:00:00 +0100 5531156 http://www.medworm.com/index.php?rid=5499823&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25516 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5499823 Mon, 12 Dec 2011 05:00:00 +0100 5499823 http://www.medworm.com/index.php?rid=5499822&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25517 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5499822 Mon, 12 Dec 2011 05:00:00 +0100 5499822 http://www.medworm.com/index.php?rid=5499821&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25518 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5499821 Mon, 12 Dec 2011 05:00:00 +0100 5499821 http://www.medworm.com/index.php?rid=5499820&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25519 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5499820 Mon, 12 Dec 2011 05:00:00 +0100 5499820 http://www.medworm.com/index.php?rid=5499819&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25520 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5499819 Mon, 12 Dec 2011 05:00:00 +0100 5499819 http://www.medworm.com/index.php?rid=5499818&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25521 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5499818 Mon, 12 Dec 2011 05:00:00 +0100 5499818 http://www.medworm.com/index.php?rid=5499817&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25523 Conclusion: Our results indicate constitutive internalization of BSEP is clathrin‐mediated and dependent on the tyrosine‐based endocytic motif at the C‐terminal end of BSEP. (HEPATOLOGY 2011.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5499817 Mon, 12 Dec 2011 05:00:00 +0100 5499817 http://www.medworm.com/index.php?rid=5499816&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25524 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5499816 Mon, 12 Dec 2011 05:00:00 +0100 5499816 http://www.medworm.com/index.php?rid=5499815&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25525 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5499815 Mon, 12 Dec 2011 05:00:00 +0100 5499815 http://www.medworm.com/index.php?rid=5499814&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25526 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5499814 Mon, 12 Dec 2011 05:00:00 +0100 5499814 http://www.medworm.com/index.php?rid=5499813&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25527 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5499813 Mon, 12 Dec 2011 05:00:00 +0100 5499813 http://www.medworm.com/index.php?rid=5663245&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25506 Conclusion:the evaluation of the impact of PNPLA3 into clinical practice may improve the diagnostic protocols and personalize therapeutic strategies in patients with chronic liver diseases. (HEPATOLOGY 2011.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5663245 Fri, 02 Dec 2011 05:00:00 +0100 5663245 http://www.medworm.com/index.php?rid=5472714&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25507 Conclusion:Detection of MHE, especially using the ICT, and subsequent treatment with lactulose could substantially reduce societal costs by preventing MVAs. (HEPATOLOGY 2011.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5472714 Fri, 02 Dec 2011 05:00:00 +0100 5472714 http://www.medworm.com/index.php?rid=5472713&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25506 Conclusion:the evaluation of the impact of PNPLA3 into clinical practice may improve the diagnostic protocols and personalize therapeutic strategies in patients with chronic liver diseases. (HEPATOLOGY 2011.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5472713 Fri, 02 Dec 2011 05:00:00 +0100 5472713 http://www.medworm.com/index.php?rid=5472712&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25508 Conclusion:Severe hepatic fibrosis is associated with a high risk of early carotid atherosclerosis in G1 CHC patients. (HEPATOLOGY 2011.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5472712 Fri, 02 Dec 2011 05:00:00 +0100 5472712 http://www.medworm.com/index.php?rid=5472711&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.25509 Conclusion:The use of pioglitazone and rosiglitazone is associated with a decreased liver cancer incidence in diabetic patients. The effects on occurrence of specific cancer types may be different for pioglitazone and rosiglitazone. (HEPATOLOGY 2011.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=5472711 Fri, 02 Dec 2011 05:00:00 +0100 5472711