MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Hepatology' source. Sat, 20 Mar 2010 15:43:10 +0100 http://www.medworm.com/index.php?rid=3377236&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23506 Conclusion: We have developed a robust and efficient method to differentiate pluripotent stem cells into hepatic cells, which exhibit characteristics of human hepatocytes. Our approach should facilitate the development of clinical grade hepatocytes for transplantation and for research on drug discovery. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3377236 Thu, 18 Mar 2010 00:00:00 +0100 3377236 http://www.medworm.com/index.php?rid=3372877&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23595 Liver transplantation was the product of five interlocking themes. These began in 1958-1959 with canine studies of then theoretical hepatotrophic molecules in portal venous blood (Theme I) and with the contemporaneous parallel development of liver and multivisceral transplant models (Theme II). Further Theme I investigations showed that insulin was the principal, although not the only, portal hepatotrophic factor. In addition to resolving long-standing controversies about the pathophysiology of portacaval shunt, the hepatotrophic studies blazed new trails in the regulation of liver size, function, and regeneration. They also targeted inborn metabolic errors (e.g., familial hyperlipoproteinemia) whose palliation by portal diversion presaged definitive correction with liver replacement. Clin... Hepatology journals http://www.medworm.com/rss/comments.php?id=3372877 Wed, 17 Mar 2010 00:00:00 +0100 3372877 http://www.medworm.com/index.php?rid=3369248&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23572 Conclusion: Synthesis of metabolically available acetyl-coA from acetate is critical to the increased acetylation of proinflammatory gene histones and consequent enhancement of the inflammatory response in ethanol-exposed macrophages. This mechanism is a potential therapeutic target in acute alcoholic hepatitis. (HEPATOLOGY 2010) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3369248 Tue, 16 Mar 2010 00:00:00 +0100 3369248 http://www.medworm.com/index.php?rid=3361702&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23518 No abstract. (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3361702 Sat, 13 Mar 2010 00:00:00 +0100 3361702 http://www.medworm.com/index.php?rid=3353226&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23567 There is a paucity of community-based epidemiological data on nonalcoholic fatty liver (NAFL) among nonaffluent populations in developing countries. Available studies are radiological and/or biochemical and lack histological assessment, limiting their strength. We conducted a prospective epidemiological study comprising a 1:3 subsample of all adult (>18 years) inhabitants of a rural administrative unit of West Bengal, India. Subjects positive for hepatitis B virus and/or hepatitis C virus infection and consuming any amount of alcohol were excluded. Diagnosis of NAFL was by dual radiological screening protocol consisting of ultrasonographic and computed tomographic examination of the liver. Transient elastographic examination and liver biopsy were performed in a subset to identify significa... Hepatology journals http://www.medworm.com/rss/comments.php?id=3353226 Thu, 11 Mar 2010 00:00:00 +0100 3353226 http://www.medworm.com/index.php?rid=3349343&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23524 Conclusion: Our data indicate that the mechanisms by which curcumin protects against fructose-induced hypertriglyceridemia and hepatic steatosis are its inhibition on PTP1B and subsequently improvement of insulin and leptin sensitivity in the liver of rats. This PTP1B inhibitory property may be a promising therapeutic strategy for curcumin to treat fructose-induced hepatic steatosis driven by hepatic insulin and leptin resistance. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3349343 Wed, 10 Mar 2010 00:00:00 +0100 3349343 http://www.medworm.com/index.php?rid=3337508&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23568 In this study, 85 HBeAg-positive patients who received peginterferon alfa-2b 1.5 [mu]g/kg/week for 32 weeks and lamivudine 100 mg/day for 52 or 104 weeks were prospectively followed for 6.1 ± 1.7 years posttreatment. Twenty-five (29%) patients had virologic response (HBeAg seroconversion and HBV DNA (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3337508 Sat, 06 Mar 2010 00:00:00 +0100 3337508 http://www.medworm.com/index.php?rid=3317673&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23559 No abstract. (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3317673 Mon, 01 Mar 2010 00:00:00 +0100 3317673 http://www.medworm.com/index.php?rid=3305497&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23512 No abstract. (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3305497 Thu, 25 Feb 2010 00:00:00 +0100 3305497 http://www.medworm.com/index.php?rid=3297472&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23516 Conclusion: CS causes oxidative stress and worsens the severity of NAFLD in obese rats. Further studies should assess whether this finding also occurs in patients with obesity and NAFLD. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3297472 Tue, 23 Feb 2010 00:00:00 +0100 3297472 http://www.medworm.com/index.php?rid=3297475&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23561 Conclusion: To address the situation, the Institute of Medicine report makes recommendations in four areas: improved surveillance for HBV and HCV; improved knowledge and awareness among healthcare and social-service providers and the public, especially at-risk people; improved HBV vaccine coverage; and improved viral hepatitis services and access to those services. HEPATOLOGY, 2010 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3297475 Mon, 22 Feb 2010 00:00:00 +0100 3297475 http://www.medworm.com/index.php?rid=3290134&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23515 Conclusion: HLA genotype influences the host capacity to clear HCV viremia. The specific HLA associations observed in the current study are unlikely to be due to chance because they were a priori hypothesized. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3290134 Sat, 20 Feb 2010 00:00:00 +0100 3290134 http://www.medworm.com/index.php?rid=3377237&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23602 Conclusion: Baculovirus-mediated genome transfer initiated a full HBV replication cycle in PMHs; this highlighted both the baculovirus efficiency in crossing the species barrier and macaque susceptibility to HBV infection. Moreover, our results demonstrate the relevance of this system for antiviral compound evaluations with either nucleoside analogues or inhibitory cytokines. Cynomolgus macaques are readily available, are immunologically closely related to humans, and may therefore represent a promising model for the development of new immunotherapeutic strategies. (HEPATOLOGY 2010) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3377237 Fri, 19 Feb 2010 00:00:00 +0100 3377237 http://www.medworm.com/index.php?rid=3278843&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23489 Conclusion: G1 CHC patients had low 25(OH)D serum levels, possibly because of reduced CYP27A1 expression. Low vitamin D is linked to severe fibrosis and low SVR on interferon (IFN)-based therapy. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3278843 Wed, 17 Feb 2010 00:00:00 +0100 3278843 http://www.medworm.com/index.php?rid=3268924&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23519 Conclusion: Our findings demonstrate that the hepatitis B X protein is critical in infecting nonproliferating hepatocytes, which contain a low dNTP level. In addition, we provide molecular evidence for a new mechanism of HBV-host cell interaction where RNR-R2, a critical cell-cycle gene, is selectively activated in nonproliferating cells. This mechanism may set the stage for formulating a new category of anti-HBV drugs. (HEPATOLOGY 2010) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3268924 Sat, 13 Feb 2010 00:00:00 +0100 3268924 http://www.medworm.com/index.php?rid=3372878&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23592 Conclusion: Our results suggest that low levels of LDL cholesterol in chronic hepatitis C patients may be a marker of host endogenous IFN response to hepatitis C and that subjects with the rs12979860 CC responder genotype may have a lower endogenous IFN response to the virus. HEPATOLOGY 2010 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3372878 Fri, 12 Feb 2010 00:00:00 +0100 3372878 http://www.medworm.com/index.php?rid=3257712&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23510 Conclusion: We propose that CD39 deficiency and changes in P2 receptor activation abrogate secretion of interferon gamma by NK cells in response to inflammatory mediators, thereby limiting tissue damage mediated by these innate immune cells during IRI. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3257712 Wed, 10 Feb 2010 00:00:00 +0100 3257712 http://www.medworm.com/index.php?rid=3246112&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23461 Little is known about hepatitis B virus (HBV) infection among patients with chronic hepatitis C virus (HCV) infection in the United States. We prospectively enrolled 1,257 patients with chronic HCV infection from two medical centers in New York City. A total of 61.5% (95% confidence interval, 58.8%-64.2%) had evidence of prior exposure to HBV (hepatitis B core antibody-positive), whereas 5.8% (95% confidence interval, 4.5%-7.1%) had dual infection with HBV (hepatitis B surface antigen-positive). Multivariable logistic regression analysis identified age (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3246112 Sat, 06 Feb 2010 00:00:00 +0100 3246112 http://www.medworm.com/index.php?rid=3238523&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23511 Conclusion: These data demonstrate that PKA-dependent up-regulation of mTOR has a central role in the proliferative, antiapoptotic, and pro-angiogenic effects of IGF1 and VEGF in polycystin-2-defective mice. This study also highlights a mechanistic link between PKA, ERK, mTOR, and HIF1[alpha]-mediated VEGF secretion and provides a proof of concept for the potential use of mTOR inhibitors in ADPKD and conditions with aberrant cholangiocyte proliferation. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3238523 Thu, 04 Feb 2010 00:00:00 +0100 3238523 http://www.medworm.com/index.php?rid=3372879&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23574 Conclusion: The comparative analysis of circulating liver mRNAs with traditional serum transaminases and histopathology indicated that the circulating liver mRNAs were more specific and more sensitive biomarkers of liver injury. Further, the possibility of identifying chemical-specific transcriptional profiles from circulating mRNAs could open a range of possibilities for identifying the etiology of drug/chemical-induced liver injury. HEPATOLOGY 2010 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3372879 Wed, 03 Feb 2010 00:00:00 +0100 3372879 http://www.medworm.com/index.php?rid=3361705&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23578 No abstract. (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3361705 Wed, 03 Feb 2010 00:00:00 +0100 3361705 http://www.medworm.com/index.php?rid=3230436&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23401 Conclusion: miR-196 directly acts on the 3[prime]-UTR of Bach1 messenger RNA and translationally represses the expression of this protein, and up-regulates HMOX1. miR-196 also inhibits HCV expression in HCV replicon cell lines (genotype 1b) and in J6/JFH1 (genotype 2a) HCV cell culture system. Thus, miR-196 plays a role in both HMOX1/Bach1 expression and the regulation of HCV expression in human hepatocytes. Overexpression of miR-196 holds promise as a potential novel strategy to prevent or ameliorate hepatitis C infection, and to protect against liver injury in chronic HCV infection. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3230436 Tue, 02 Feb 2010 00:00:00 +0100 3230436 http://www.medworm.com/index.php?rid=3357642&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23569 Conclusion: This is the first report that the G protein-coupled receptor GLP-1R is present on human hepatocytes. Furthermore, it appears that exendin-4 has the same beneficial effects in vitro as those seen in our previously published in vivo study in ob/ob mice, directly reducing hepatocyte steatosis. Future use for human nonalcoholic fatty liver disease, either in combination with dietary manipulation or other pharmacotherapy, may be a significant advance in treatment of this common form of liver disease. (HEPATOLOGY 2010) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3357642 Mon, 01 Feb 2010 00:00:00 +0100 3357642 http://www.medworm.com/index.php?rid=3337511&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23540 Conclusion: Taken together, our findings suggest that TAT plays an important suppressive role in the development and progression of HCC. (Hepatology 2010;) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3337511 Mon, 01 Feb 2010 00:00:00 +0100 3337511 http://www.medworm.com/index.php?rid=3337509&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23566 Conclusion: Our findings suggest that the p38 MAPK pathway plays a crucial role in miR-17-5p-induced phosphorylation of HSP27 and, as a consequence, phosphorylated HSP27 enhances the migration of HCC cells. Our data highlight an important role of miR-17-5p in the proliferation and migration of HCC cells and support the potential application of miR-17-5p in HCC therapy. (Hepatology 2010;) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3337509 Mon, 01 Feb 2010 00:00:00 +0100 3337509 http://www.medworm.com/index.php?rid=3219350&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23485 Conclusion: This meta-analysis confirms the heterogeneity of behavior of untreated HCC and provides a sound basis for stratifying patients with HCC according to expected survival in future trials of new anti-cancer agents. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3219350 Fri, 29 Jan 2010 00:00:00 +0100 3219350 http://www.medworm.com/index.php?rid=3377238&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23535 The rising incidence of obesity and diabetes coincides with a marked increase in fructose consumption. Fructose consumption is higher in individuals with nonalcoholic fatty liver disease (NAFLD) than in age-matched and body mass index (BMI)-matched controls. Because fructose elicits metabolic perturbations that may be hepatotoxic, we investigated the relationship between fructose consumption and disease severity in NAFLD. We studied 427 adults enrolled in the NASH Clinical Research Network for whom Block food questionnaire data were collected within 3 months of a liver biopsy. Fructose consumption was estimated based on reporting (frequency × amount) of Kool-aid, fruit juices, and nondietary soda intake, expressed as servings per week, and classified into none, minimum to moderate ( (Sour... Hepatology journals http://www.medworm.com/rss/comments.php?id=3377238 Thu, 28 Jan 2010 00:00:00 +0100 3377238 http://www.medworm.com/index.php?rid=3369254&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23557 No abstract. (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3369254 Thu, 28 Jan 2010 00:00:00 +0100 3369254 http://www.medworm.com/index.php?rid=3369253&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23560 No abstract. (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3369253 Thu, 28 Jan 2010 00:00:00 +0100 3369253 http://www.medworm.com/index.php?rid=3369252&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23562 No abstract. (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3369252 Thu, 28 Jan 2010 00:00:00 +0100 3369252 http://www.medworm.com/index.php?rid=3369251&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23536 Conclusion: Peripheral tolerance and development of regulatory T cells after self-mimicking antigen exposure, and not sexual hormone nor central tolerance, are the main factors for susceptibility to AIH in females. (Hepatology 2010) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3369251 Thu, 28 Jan 2010 00:00:00 +0100 3369251 http://www.medworm.com/index.php?rid=3369250&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23539 Conclusion: PFIC1 and PFIC2 differ clinically, biochemically, and histologically at presentation and/or during the disease course. A small proportion of normal-GGT PFIC is likely not due to ATP8B1 or ABCB11 mutations. (HEPATOLOGY 2010) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3369250 Thu, 28 Jan 2010 00:00:00 +0100 3369250 http://www.medworm.com/index.php?rid=3369249&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23564 Over the last 4 years, more than 450 genome-wide association studies (GWAS) have been successfully performed in a variety of human traits, of which approximately 2% relates to the field of hepatology. Whereas the many robust susceptibility gene findings have provided insight into fundamental physiological aspects of the phenotypes that have been studied, the widespread application has also revealed important limitations of the GWAS design. This review aims to systematically summarize both the strengths and the weaknesses of GWAS, as well as underscore important experiences made in model diseases outside the field of hepatology. By reviewing the GWAS performed in hepatology so far on this broader background, extensions and guidelines for the rational application of the study design in hepat... Hepatology journals http://www.medworm.com/rss/comments.php?id=3369249 Thu, 28 Jan 2010 00:00:00 +0100 3369249 http://www.medworm.com/index.php?rid=3361706&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23555 No abstract. (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3361706 Thu, 28 Jan 2010 00:00:00 +0100 3361706 http://www.medworm.com/index.php?rid=3357643&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23537 Conclusion: Serum ferritin concentration is an independent predictor of mortality-related and liver-related clinical events. Baseline serum ferritin identifies a group of "higher-risk" patients awaiting OLT and should be investigated as an adjunct to MELD in organ allocation. (HEPATOLOGY 2010) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3357643 Thu, 28 Jan 2010 00:00:00 +0100 3357643 http://www.medworm.com/index.php?rid=3353227&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23549 Conclusion: Flucloxacillin is a PXR agonist at pharmacologically relevant concentrations, and a functionally significant upstream PXR polymorphism is a risk factor for flucloxacillin-induced DILI. Hepatology 2010 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3353227 Thu, 28 Jan 2010 00:00:00 +0100 3353227 http://www.medworm.com/index.php?rid=3337513&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23558 No abstract. (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3337513 Thu, 28 Jan 2010 00:00:00 +0100 3337513 http://www.medworm.com/index.php?rid=3337510&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23543 Conclusion: At least one-quarter of HB vaccinees have lost their immune memory to the HB vaccine when entering college. Immune memory to HB vaccine was identified by early seroconversion, which was present in only 20% of vaccinees in the present study. To ensure higher than 90% anti-HBs seroconversion rates, at least 2 doses of HB booster vaccines are recommended for at-risk youths who received complete HB vaccinations in neonatal or infant periods but are seronegative for HBsAg, anti-HBs, and anti-HBc in adolescence. (Hepatology 2010;) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3337510 Thu, 28 Jan 2010 00:00:00 +0100 3337510 http://www.medworm.com/index.php?rid=3317676&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23532 Conclusion: Inflammation-mediated STAT3 activation attenuates hepatocellular injury induced by CCl4 in myeloid-specific STAT3 knockout mice, suggesting that inflammation associated with a predominance of hepatoprotective cytokines that activate hepatic STAT3 may reduce rather than accelerate hepatocellular damage in patients with chronic liver diseases. Hepatology 2010 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3317676 Thu, 28 Jan 2010 00:00:00 +0100 3317676 http://www.medworm.com/index.php?rid=3317675&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23534 Conclusion: ATT-ALF constituted 5.7% of ALF at our center and had a high mortality rate. Because the mortality rate is so high, determining which factors are predictors is less important. A high proportion of patients had consumed ATT empirically, which could have been prevented. Hepatology 2010 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3317675 Thu, 28 Jan 2010 00:00:00 +0100 3317675 http://www.medworm.com/index.php?rid=3317674&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23544 Conclusion: TGF[beta]1 is able to regulate CD133 expression through inhibition of DNMT1 and DNMT3[beta] expression and subsequent demethylation of promoter-1. TGF[beta]1-induced CD133+ Huh7 cells are tumorigenic. The mechanism by which TGF[beta] induces CD133 expression is partially dependent on the Smads pathway. Hepatology 2010 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3317674 Thu, 28 Jan 2010 00:00:00 +0100 3317674 http://www.medworm.com/index.php?rid=3337512&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23527 Conclusion: Patients with NASH cirrhosis have a greatly increased risk of liver cancer. Alcohol consumption, a modifiable risk factor, appears to be the most significant factor associated with risk of HCC development in our study population. (Hepatology 2010;) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3337512 Wed, 27 Jan 2010 00:00:00 +0100 3337512 http://www.medworm.com/index.php?rid=3317679&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23528 Conclusion: In the long term, the achievement of SVR prevents the development of EV in patients with compensated HCV-induced cirrhosis. Therefore, in these patients, endoscopic surveillance can be safely delayed or avoided. Genotype 1b infection and MELD score identify the subset of patients at higher risk of EV development who need tailored endoscopic surveillance. Hepatology 2010 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3317679 Wed, 27 Jan 2010 00:00:00 +0100 3317679 http://www.medworm.com/index.php?rid=3317678&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23530 Conclusion: DUSP1 mRNA and protein levels are lower in Mat1a KO livers and fall rapidly in cultured hepatocytes. SAM treatment increases DUSP1 expression through multiple mechanisms, and this may suppress ERK activity and malignant degeneration. Hepatology 2010 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3317678 Wed, 27 Jan 2010 00:00:00 +0100 3317678 http://www.medworm.com/index.php?rid=3317677&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23531 The objective of this analysis was to compare sustained virological response (SVR) and relapse rates in patients with a rapid virological response (RVR, HCV RNA (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3317677 Wed, 27 Jan 2010 00:00:00 +0100 3317677 http://www.medworm.com/index.php?rid=3199738&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23479 Conclusion: This study provides in vivo evidence that increased apoptosis of hepatocytes not only impairs liver homeostasis but is also accompanied by hepatocyte proliferation and hepatocarcinogenesis. Our findings might have implications for understanding apoptosis-related human liver diseases. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3199738 Sat, 23 Jan 2010 00:00:00 +0100 3199738 http://www.medworm.com/index.php?rid=3192498&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23462 We aimed to determine the antiviral activity and safety of a new nucleotide analogue, LB80380, in chronic hepatitis B (CHB) patients with lamivudine-resistant virus. Sixty-five patients with lamivudine-resistant virus were randomized to receive five ascending daily doses (30, 60, 90, 150, 240 mg) of LB80380. LB80380 was given together with lamivudine for the first 4 weeks, followed by 8 weeks of LB80380 monotherapy. This was then followed by 24 weeks of adefovir. Hepatitis B virus (HBV) DNA levels, serology, liver biochemistry, and safety were monitored. The extent of the HBV DNA reduction at week 12 was dose-dependent. The mean reduction from baseline was 2.81, 3.21, 3.92, 4.16, and 4.00 log10 copies/mL for the five ascending dose groups. The dose-proportionate effect was statistically si... Hepatology journals http://www.medworm.com/rss/comments.php?id=3192498 Thu, 21 Jan 2010 00:00:00 +0100 3192498 http://www.medworm.com/index.php?rid=3188054&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23464 Conclusion: HCC can occur in persons with chronic hepatitis B who have lost HBsAg, even in the absence of cirrhosis. These persons should still be followed with periodic liver ultrasound to detect HCC early. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3188054 Wed, 20 Jan 2010 00:00:00 +0100 3188054 http://www.medworm.com/index.php?rid=3174668&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23492 No abstract. (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3174668 Fri, 15 Jan 2010 00:00:00 +0100 3174668 http://www.medworm.com/index.php?rid=3166127&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23445 Conclusion: These results further define the function of CLDN1 in the HCV entry process and highlight new antiviral strategies targeting E2-CD81-CLDN1 interactions. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3166127 Wed, 13 Jan 2010 00:00:00 +0100 3166127 http://www.medworm.com/index.php?rid=3155424&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23425 Conclusion: In our experience, liver stiffness measurements are uninterpretable in nearly one in five cases. The principal reasons are obesity, particularly increased waist circumference, and limited operator experience. These results emphasize the need for adequate operator training and for technological improvements in specific patient subpopulations. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3155424 Sat, 09 Jan 2010 00:00:00 +0100 3155424 http://www.medworm.com/index.php?rid=3152282&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23385 Conclusion: c-Rel has multiple functions in the control of liver homeostasis and regeneration and is a transcriptional regulator of FoxM1 and compensatory hepatocyte proliferation. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3152282 Fri, 08 Jan 2010 00:00:00 +0100 3152282 http://www.medworm.com/index.php?rid=3148236&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23491 No abstract. (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3148236 Thu, 07 Jan 2010 00:00:00 +0100 3148236 http://www.medworm.com/index.php?rid=3141483&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23429 Randomized controlled trials of hepatitis C virus (HCV) therapy with pegylated interferon and ribavirin have demonstrated sustained viral response rates (SVRs) of 54%-63% (efficacy). Treatment results in clinical practice (effectiveness) may not be equivalent. The goal of this study was to assess the effectiveness of HCV treatment with pegylated interferon and ribavirin in a treatment-naïve, human immunodeficiency virus (HIV)-negative, United States urban population with many ethnic minority patients. We evaluated 2,370 outpatients for HCV therapy from 2001 to 2006 in the Faculty Practice of the Albert Einstein College of Medicine or the attending-supervised Montefiore Medical Center Liver Clinic. Care was supervised by one experienced physician under conditions of everyday clinical pract... Hepatology journals http://www.medworm.com/rss/comments.php?id=3141483 Tue, 05 Jan 2010 00:00:00 +0100 3141483 http://www.medworm.com/index.php?rid=3141484&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23327 We present the results after up to 5 years (240 weeks) of continuous entecavir therapy. The entecavir long-term cohort consists of patients who received [ge]1 year of entecavir 0.5 mg in ETV-022 and then entered ETV-901 with a treatment gap [le]35 days. In ETV-901 the entecavir dose was 1.0 mg daily. For patients with samples available at Year 5, proportions with hepatitis B virus (HBV) DNA (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3141484 Mon, 04 Jan 2010 00:00:00 +0100 3141484 http://www.medworm.com/index.php?rid=3134995&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23436 Cholesterol homeostasis is critical for cellular proliferation. Liver X receptor (LXR) [alpha] and [beta] are the nuclear receptors responsible for regulation of cholesterol metabolism. In physiological conditions, high intracellular cholesterol levels cause increased synthesis of oxysterols, which activate LXR, thus triggering a transcriptional response for cholesterol secretion and catabolism. Here we employed a mouse model of partial hepatectomy (PH) to dissect the molecular pathways connecting cholesterol homeostasis, cellular proliferation, and LXR. First, we show that hepatic cholesterol content increases after PH, whereas the entire LXR transcriptome is down-regulated. Although LXR messenger RNA (mRNA) levels are unmodified, LXR target genes are significantly down-regulated on day 1... Hepatology journals http://www.medworm.com/rss/comments.php?id=3134995 Fri, 01 Jan 2010 00:00:00 +0100 3134995 http://www.medworm.com/index.php?rid=3132812&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23388 Conclusion: Hepatitis C virus-induced overexpression of PP2Ac contributes to hepatocarcinogenesis through dysregulation of epigenetic histone modifications. The correction of defective histone modifications by S-adenosyl-L-methionine makes this drug a candidate for chemopreventive therapies in patients with chronic hepatitis C who are at risk for developing hepatocellular carcinoma. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3132812 Thu, 31 Dec 2009 00:00:00 +0100 3132812 http://www.medworm.com/index.php?rid=3126064&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23439 No abstract. (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3126064 Tue, 29 Dec 2009 00:00:00 +0100 3126064 http://www.medworm.com/index.php?rid=3361703&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23517 No abstract. (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3361703 Wed, 23 Dec 2009 00:00:00 +0100 3361703 http://www.medworm.com/index.php?rid=3305498&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23504 Conclusion: Current evidence suggests that peginterferon alpha-2a is associated with higher SVR than peginterferon alfa-2b. However, the paucity of evidence on adverse events curbs the decision to definitively recommend one peginterferon over the other, because any potential benefit must outweigh the risk of harm. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3305498 Wed, 23 Dec 2009 00:00:00 +0100 3305498 http://www.medworm.com/index.php?rid=3297473&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23509 Conclusion: In patients with chronic hepatitis C, low levels of intrahepatic and systemic IP-10 predict a favorable first-phase decline of HCV RNA during therapy with pegylated interferon and ribavirin for genotypes of HCV. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3297473 Wed, 23 Dec 2009 00:00:00 +0100 3297473 http://www.medworm.com/index.php?rid=3278849&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23505 A recent study in young Italian subjects suggested that the healthy thresholds for serum alanine aminotransferase (ALT) levels should be adjusted to 30 IU/L for men and 19 IU/L for women when assessing risk factors for nonalcoholic fatty liver disease. Our aim was to assess serum ALT concentrations in healthy Korean individuals and to determine the factors affecting ALT levels in these populations. We included 1,105 potential liver donors (643 men and 462 women) with biopsy-proven normal livers. Median ages were 25 years in men and 30 years in women, with a median body mass index (BMI) of 22.3 kg/m2 in men and 21.4 kg/m2 in women. The calculated thresholds for ALT values in these subjects were 35 IU/L for men and 26 IU/L for women. Age and BMI were independently correlated with ALT levels ... Hepatology journals http://www.medworm.com/rss/comments.php?id=3278849 Wed, 23 Dec 2009 00:00:00 +0100 3278849 http://www.medworm.com/index.php?rid=3278847&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23514 No abstract. (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3278847 Wed, 23 Dec 2009 00:00:00 +0100 3278847 http://www.medworm.com/index.php?rid=3095547&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23415 No abstract. (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3095547 Thu, 17 Dec 2009 00:00:00 +0100 3095547 http://www.medworm.com/index.php?rid=3081653&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23314 Conclusion: Patients with NASH are at increased risk of death compared with the general population. Liver disease is the third most common cause of death among patients with NAFLD. (HEPATOLOGY 2009.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3081653 Sat, 12 Dec 2009 00:00:00 +0100 3081653 http://www.medworm.com/index.php?rid=3278850&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23502 Conclusion: Our results reveal that the core/FBG-[beta] interaction may act as a regulatory feedback, allowing repression of IL-6-stimulated APR genes. Together, these data suggested a network of interactions between HCV core and the hepatic APR genes, and may contribute to impaired innate immunity for viral persistence. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3278850 Thu, 10 Dec 2009 00:00:00 +0100 3278850 http://www.medworm.com/index.php?rid=3297474&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23500 Conclusion: Patients with alcoholic cirrhosis had a high prevalence of complications at the time of cirrhosis diagnosis. The presence and type of complications at diagnosis were predictors of mortality, but not of the risk of subsequent complications. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3297474 Wed, 09 Dec 2009 00:00:00 +0100 3297474 http://www.medworm.com/index.php?rid=3278852&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23496 No abstract. (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3278852 Wed, 09 Dec 2009 00:00:00 +0100 3278852 http://www.medworm.com/index.php?rid=3278851&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23499 Conclusion: Vitamin C deficiency by SMP30 depletion attenuated liver fibrosis by way of up-regulated PPAR-[gamma] expression in SMP30 KO mice. Our results provide, for the first time, the possible mechanisms underlying inhibition of HSC activation associated with vitamin C and PPAR-[gamma] up-regulation in liver fibrosis of SMP30 KO mice. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3278851 Wed, 09 Dec 2009 00:00:00 +0100 3278851 http://www.medworm.com/index.php?rid=3238524&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23501 Interferon regulatory factor-1 (IRF-1) is a transcription factor that regulates gene expression during immunity. We hypothesized that IRF-1 plays a pivotal role in liver transplant (LTx) ischemia/reperfusion (I/R) injury. Mouse orthotopic LTx was conducted after 24 hours cold storage in University of Wisconsin (UW) solution in wildtype (WT) C57BL/6 and IRF-1 knockout (KO) mice. IRF-1 deficiency in liver grafts, but not in recipients, resulted in significant reduction of hepatocyte apoptosis and liver injury, as well as improved survival. IRF-1 mRNA up-regulation was typically seen in graft hepatocytes in WT[rarr]WT LTx. Deficiency of IRF-1 signaling in graft resulted in significantly reduced messenger RNA (mRNA) levels for death ligands and death receptors in hepatocytes, as well as decrea... Hepatology journals http://www.medworm.com/rss/comments.php?id=3238524 Wed, 09 Dec 2009 00:00:00 +0100 3238524 http://www.medworm.com/index.php?rid=3070111&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23408 Conclusion: Bile salt sequestration by colesevelam induces the lipogenic pathway in an FXR- and LXR[alpha]-dependent manner without affecting the total pool size of bile salts in mice. We speculate that a shift from intestinal reabsorption to de novo synthesis as source of bile salts upon bile salt sequestration affects zonation of metabolic processes within the liver acinus. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3070111 Wed, 09 Dec 2009 00:00:00 +0100 3070111 http://www.medworm.com/index.php?rid=3361704&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23493 No abstract. (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3361704 Tue, 08 Dec 2009 00:00:00 +0100 3361704 http://www.medworm.com/index.php?rid=3070115&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23253 Conclusion: Our findings suggest an important role for MIC A/B in liver injury. Therapeutic intervention aimed at reducing MIC A/B levels may beneficially affect the progression of NASH. (HEPATOLOGY 2009.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3070115 Tue, 08 Dec 2009 00:00:00 +0100 3070115 http://www.medworm.com/index.php?rid=3278844&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23486 Conclusion: Our results revealed that ECHS1 down-regulation contributed to HFD-induced hepatic steatosis, which may help clarify the pathogenesis of NAFLD and point to potential targets for therapeutic interventions. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3278844 Fri, 04 Dec 2009 00:00:00 +0100 3278844 http://www.medworm.com/index.php?rid=3148237&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23488 Conclusion: Our data establish CK19 as a prognostic marker of early neoplastic lesions and strongly suggest the progenitor derivation of HCC in the rat RH model. The capacity of CK19-associated gene signatures to stratify HCC patients according to clinical prognosis indicates the usefulness of the RH model for studies of stem/progenitor-derived HCC. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3148237 Fri, 04 Dec 2009 00:00:00 +0100 3148237 http://www.medworm.com/index.php?rid=3058917&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23324 Conclusion: [gamma]-GT is a strong risk indicator of all-cause occupational disability even at levels of [gamma]-GT in the "normal range" and is in particular associated with disability pension due to diseases of the digestive system, musculoskeletal disorders, cardiovascular, and mental diseases. (HEPATOLOGY 2009.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3058917 Fri, 04 Dec 2009 00:00:00 +0100 3058917 http://www.medworm.com/index.php?rid=3055371&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23409 No abstract. (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3055371 Fri, 04 Dec 2009 00:00:00 +0100 3055371 http://www.medworm.com/index.php?rid=3051264&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23396 No abstract. (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3051264 Thu, 03 Dec 2009 00:00:00 +0100 3051264 http://www.medworm.com/index.php?rid=3278853&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23481 Conclusion: AAV-mediated gene repair is feasible in vivo and can functionally correct an appropriate selection-based metabolic liver disease in both adults and neonates. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3278853 Mon, 30 Nov 2009 00:00:00 +0100 3278853 http://www.medworm.com/index.php?rid=3278846&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23469 Conclusion: Our data suggest that loss of STAT5 sensitizes hepatocytes to bile acid-induced damage and apoptosis caused by disruption of GH-induced transcription of Igf-1 and down-regulation of hepatoprotective genes. These findings could contribute to the understanding of liver fibrosis and future treatment strategies for liver fibrosis. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3278846 Mon, 30 Nov 2009 00:00:00 +0100 3278846 http://www.medworm.com/index.php?rid=3278845&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23480 No abstract. (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3278845 Mon, 30 Nov 2009 00:00:00 +0100 3278845 http://www.medworm.com/index.php?rid=3257714&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23460 Conclusion: Caveolin-1 is enriched in peroxisomes of hepatocytes. Caveolin-1 is not required for peroxisome biogenesis, but this unique subcellular location may determine its important role in hepatocyte proliferation and lipid metabolism. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3257714 Mon, 30 Nov 2009 00:00:00 +0100 3257714 http://www.medworm.com/index.php?rid=3257713&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23471 Conclusion: Toxic bile acid induces a switch from Nrf2 to c-Maf/MafG ARE nuclear binding, which leads to decreased expression of GSH synthetic enzymes and GSH levels and contributes to liver injury during BDL. UDCA and SAMe treatment targets this switch. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3257713 Mon, 30 Nov 2009 00:00:00 +0100 3257713 http://www.medworm.com/index.php?rid=3238525&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23449 Conclusion: TGF-[beta] signaling, particularly [beta]2SP, plays a critical role in hepatocyte proliferation and transitional phenotype and its loss is associated with activation of hepatic progenitor cells secondary to delayed mitogenesis and activated Wnt signaling. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3238525 Mon, 30 Nov 2009 00:00:00 +0100 3238525 http://www.medworm.com/index.php?rid=3219354&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23451 Conclusion: EIF5A2 plays an important role in HCC invasion and metastasis by inducing EMT, as well as stimulating cytoskeleton rearrangement through activation of RhoA and Rac1. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3219354 Mon, 30 Nov 2009 00:00:00 +0100 3219354 http://www.medworm.com/index.php?rid=3219353&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23463 Conclusion: These combined data indicate that hyperlipidemic mice lacking 5-LO are protected against hepatic inflammatory injury, suggesting that 5-LO is involved in mounting hepatic inflammation in metabolic disease. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3219353 Mon, 30 Nov 2009 00:00:00 +0100 3219353 http://www.medworm.com/index.php?rid=3219352&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23467 Conclusion: PLK1-4 proteins are aberrantly regulated and possess different roles in human HCC, with PLK1 acting as an oncogene and PLK2-4 being presumably tumor suppressor genes. Thus, therapeutic approaches aimed at inactivating PLK1 and/or reactivating PLK2-4 might be highly useful in the treatment of human liver cancer. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3219352 Mon, 30 Nov 2009 00:00:00 +0100 3219352 http://www.medworm.com/index.php?rid=3219351&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23470 Hepatocellular carcinoma (HCC) is a common cause of death from solid organ malignancy worldwide. Extracellular signal-regulated/mitogen-activated protein kinase kinase (MEK) signaling is a critical growth regulatory pathway in HCC. Targeting MEK with a novel small molecule inhibitor, PD0325901, may inhibit HCC tumorigenesis. PD0325901 (0.01-100 nM) inhibited growth and MEK activity in vitro in immortalized murine transforming growth factor alpha (TGF-[alpha]) transgenic hepatocyte (TAMH) cells, derived from the livers of TGF-[alpha] transgenic mice. Treatment of athymic mice bearing TAMH flank tumors with vehicle or PD0325901 (20 mg/kg) revealed a significant reduction of MEK activity ex vivo 24 hours after a single PD0325901 dose. The growth rate of TAMH flank tumors over 16 days was redu... Hepatology journals http://www.medworm.com/rss/comments.php?id=3219351 Mon, 30 Nov 2009 00:00:00 +0100 3219351 http://www.medworm.com/index.php?rid=3199742&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23448 Conclusion: HFE C282Y homozygotes have twice the risk of colorectal and breast cancer compared with those individuals without the C282Y variant. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3199742 Mon, 30 Nov 2009 00:00:00 +0100 3199742 http://www.medworm.com/index.php?rid=3199741&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23456 Conclusion: ADAM9 is involved in MICA ectodomain shedding in HCC cells, and sorafenib can modulate ADAM9 expression. Sorafenib therapy may have a previously unrecognized effect on antitumor immunity in patients with HCC. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3199741 Mon, 30 Nov 2009 00:00:00 +0100 3199741 http://www.medworm.com/index.php?rid=3199740&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23466 No adequate randomized trials have been reported for a comparison between hepatic resection (HR) versus radiofrequency ablation (RFA) for the treatment of patients with very early stage hepatocellular carcinoma (HCC), defined as an asymptomatic solitary HCC (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3199740 Mon, 30 Nov 2009 00:00:00 +0100 3199740 http://www.medworm.com/index.php?rid=3199739&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23476 Conclusion: Collectively, our data indicate that Lac, through activation of KCs, inhibited APAP-induced liver sinusoidal endothelial cell damage and improved hepatic congestion, thereby protecting against AILI. These findings reveal the significant therapeutic potential of Lac during AILI and other types of liver diseases. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3199739 Mon, 30 Nov 2009 00:00:00 +0100 3199739 http://www.medworm.com/index.php?rid=3192500&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23442 The T cell immunoglobulin and mucin domain-containing molecules (TIM) protein family, which is expressed by T cells, plays a crucial role in regulating host adaptive immunity and tolerance. However, its role in local inflammation, such as innate immunity-dominated organ ischemia-reperfusion injury (IRI), remains unknown. Liver IRI occurs frequently after major hepatic resection or liver transplantation. Using an antagonistic anti-TIM-1 antibody (Ab), we studied the role of TIM-1 signaling in the model of partial warm liver ischemia followed by reperfusion. Anti-TIM-1 Ab monotherapy ameliorated the hepatocellular damage and improved liver function due to IR, as compared with controls. Histological examination has revealed that anti-TIM-1 Ab treatment decreased local neutrophil infiltration,... Hepatology journals http://www.medworm.com/rss/comments.php?id=3192500 Mon, 30 Nov 2009 00:00:00 +0100 3192500 http://www.medworm.com/index.php?rid=3192499&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23450 Conclusion: This study reports genome-wide FXR binding in vivo and the results clearly demonstrate tissue-specific FXR/gene interaction. In addition, FXR may be involved in regulating broader biological pathways in maintaining hepatic and intestinal homeostasis. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3192499 Mon, 30 Nov 2009 00:00:00 +0100 3192499 http://www.medworm.com/index.php?rid=3174670&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23477 Conclusion: KIR and HLA-C genes are consistently beneficial determinants in the outcome of HCV infection. This advantage extends to the allelic level for both gene families. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3174670 Mon, 30 Nov 2009 00:00:00 +0100 3174670 http://www.medworm.com/index.php?rid=3174669&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23478 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3174669 Mon, 30 Nov 2009 00:00:00 +0100 3174669 http://www.medworm.com/index.php?rid=3166128&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23444 Conclusion: Our results show that the assessment of serum HCV-RNA 12 weeks after the end of treatment, using the highly sensitive TMA assay (PPV 99.7%), is as relevant as after 24 weeks to predict SVR and make decisions on the management of treated patients, suggesting a new definition for SVR. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3166128 Mon, 30 Nov 2009 00:00:00 +0100 3166128 http://www.medworm.com/index.php?rid=3148238&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23443 Conclusion: The newly identified miR-30d/GNAI2 axis elucidates the molecular mechanism of HCC cell invasion and metastasis and represents a new potential therapeutic target for HCC treatment. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3148238 Mon, 30 Nov 2009 00:00:00 +0100 3148238 http://www.medworm.com/index.php?rid=3126072&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23447 No abstract. (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3126072 Mon, 30 Nov 2009 00:00:00 +0100 3126072 http://www.medworm.com/index.php?rid=3014605&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23377 Conclusion: We report a novel pathological SLC40A1 variant associated with abnormal cell surface expression of ferroportin due to intracellular retention of the mutant protein. These findings predict macrophage-type ferroportin disease, the phenotype observed in this kindred. Study of the molecular cell biology of ferroportin and its mutants is key to understanding the pathogenesis of this increasingly recognized form of hemochromatosis, which responds poorly to conventional therapy. (HEPATOLOGY 2009.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3014605 Sat, 21 Nov 2009 00:00:00 +0100 3014605 http://www.medworm.com/index.php?rid=3199743&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23441 Conclusion: This study provides evidence that serotonin is involved in tumor growth of hepatocellular cancer by activating downstream targets of mTOR, and therefore serotonin-related pathways might represent a new treatment strategy. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3199743 Fri, 20 Nov 2009 00:00:00 +0100 3199743 http://www.medworm.com/index.php?rid=3188055&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23440 Conclusion: Common NOD2 variants linked previously to impaired mucosal barrier function may be genetic risk factors for death and SBP. These findings might serve to identify patients with cirrhotic ascites eligible for preemptive antibiotic treatment. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3188055 Fri, 20 Nov 2009 00:00:00 +0100 3188055 http://www.medworm.com/index.php?rid=2998500&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23344 Posttranscriptional regulation of gene expression is increasingly recognized as a model for inherited and acquired disease. Recent work has expanded understanding of the range of mechanisms that regulate several of these distinct steps, including messenger RNA (mRNA) splicing, trafficking, and/or stability. Each of these pathways is implicated in disease pathogenesis, and each represents important avenues for therapeutic intervention. This review summarizes important mechanisms controlling mRNA processing and the regulation of mRNA degradation, including the role of microRNAs and RNA binding proteins. These pathways provide important opportunities for therapeutic targeting directed at splicing and degradation in order to attenuate genetic defects in RNA metabolism. We will highlight develo... Hepatology journals http://www.medworm.com/rss/comments.php?id=2998500 Tue, 17 Nov 2009 00:00:00 +0100 2998500 http://www.medworm.com/index.php?rid=2998505&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23319 Conclusion: Apparent mutational escape can occur in MHC class II-restricted epitopes, but this is uncommon when compared with class I-restricted epitopes in the same individual. This indicates that other mechanisms for silencing CD4 T cells are dominant in persistent HCV infections. (HEPATOLOGY 2009.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=2998505 Mon, 16 Nov 2009 00:00:00 +0100 2998505 http://www.medworm.com/index.php?rid=2998504&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23322 Conclusion:During CDE treatment mice lacking IL-6 and gp130-STAT signaling in hepatocytes are prone to hepatic metabolic changes and inflammation. This ultimately leads to progressive steatohepatitis with signs of liver remodeling. Thus, the presented model allows one to further dissect the role of IL-6/gp130-type signaling in hepatocytes during fatty liver degeneration to define new therapeutic targets in metabolic liver diseases. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=2998504 Mon, 16 Nov 2009 00:00:00 +0100 2998504 http://www.medworm.com/index.php?rid=3305499&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23437 Conclusion: According to these data, sirolimus-based immunosuppression has unique posttransplant effects on HCC patients that lead to improved survival. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3305499 Fri, 13 Nov 2009 00:00:00 +0100 3305499 http://www.medworm.com/index.php?rid=3278848&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23435 Conclusion: The results underscore an important role of platelets in chronic liver damage and imply a new target for antifibrotic therapies. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3278848 Fri, 13 Nov 2009 00:00:00 +0100 3278848 http://www.medworm.com/index.php?rid=3166129&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23431 Conclusion: There is a threshold requirement for Notch signaling at multiple steps, including IHBD tubulogenesis and maintenance, during hepatic development that determines the density of three-dimensional peripheral IHBD architecture. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3166129 Fri, 13 Nov 2009 00:00:00 +0100 3166129 http://www.medworm.com/index.php?rid=3148242&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23427 Conclusion: gAcrp prevents LPS-stimulated TNF-[alpha] expression in Kupffer cells through the activation of the IL-10/STAT3/HO-1 pathway. Kupffer cells from ethanol-fed rats are highly sensitive to the anti-inflammatory effects of gAcrp; this sensitivity is associated with both increased expression and sensitivity to IL-10. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3148242 Fri, 13 Nov 2009 00:00:00 +0100 3148242 http://www.medworm.com/index.php?rid=3134998&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23426 Hepatitis C virus (HCV) infection induces the endogenous interferon (IFN) system in the liver in some but not all patients with chronic hepatitis C (CHC). Patients with a pre-activated IFN system are less likely to respond to the current standard therapy with pegylated IFN-[alpha]. Mitochondrial antiviral signaling protein (MAVS) is an important adaptor molecule in a signal transduction pathway that senses viral infections and transcriptionally activates IFN-[beta]. The HCV NS3-4A protease can cleave and thereby inactivate MAVS in vitro, and, therefore, might be crucial in determining the activation status of the IFN system in the liver of infected patients. We analyzed liver biopsies from 129 patients with CHC to investigate whether MAVS is cleaved in vivo and whether cleavage prevents th... Hepatology journals http://www.medworm.com/rss/comments.php?id=3134998 Fri, 13 Nov 2009 00:00:00 +0100 3134998 http://www.medworm.com/index.php?rid=3134997&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23428 Conclusion: Our data implicate mig-6 as a regulator of EGFR activity in hepatocytes and as a suppressor of EGFR signaling in human liver cancer. (HEPATOLOGY 2009.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3134997 Fri, 13 Nov 2009 00:00:00 +0100 3134997 http://www.medworm.com/index.php?rid=3134996&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23432 Conclusion: A higher Mayo risk score and higher AST/ALT ratio were significantly associated with the presence of varices at initial endoscopy. Lower platelet count and higher total bilirubin at 2 years were significantly associated with an increased risk of developing new varices in patients with PSC. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3134996 Fri, 13 Nov 2009 00:00:00 +0100 3134996 http://www.medworm.com/index.php?rid=3126073&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23438 No abstract. (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3126073 Fri, 13 Nov 2009 00:00:00 +0100 3126073 http://www.medworm.com/index.php?rid=3126066&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23430 Conclusion: An interplay of myeloid and hepatic STAT3 signaling is essential to prevent liver failure during liver regeneration through tempering a strong innate inflammatory response mediated by STAT1 signaling. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3126066 Fri, 13 Nov 2009 00:00:00 +0100 3126066 http://www.medworm.com/index.php?rid=3126065&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23433 No abstract. (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3126065 Fri, 13 Nov 2009 00:00:00 +0100 3126065 http://www.medworm.com/index.php?rid=2983960&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23318 Conclusion: There are common properties of ECs, LSECs, and BECs, whether derived from PBC or viral hepatitis, but there are also significant differences, particularly in the potential in PBC for LMCs to adhere to ECs and BECs and to produce TNF-[alpha]; such properties were associated with augmented CX3CL1 production by BEC from PBC liver. The processes defined herein suggest potential novel biotherapies for biliary specific inflammation. (HEPATOLOGY 2009.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=2983960 Wed, 11 Nov 2009 00:00:00 +0100 2983960 http://www.medworm.com/index.php?rid=2979990&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23365 Conclusion: TLR9 serves as an endogenous sensor of tissue necrosis that exacerbates the innate immune response during liver I/R. Combined blockade of TLR9 and HMGB1 represents a clinically relevant, novel approach to limiting I/R injury. (HEPATOLOGY 2009.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=2979990 Wed, 11 Nov 2009 00:00:00 +0100 2979990 http://www.medworm.com/index.php?rid=3238526&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23420 Conclusion: NASH and SS livers are both more susceptible to IRI. Mechanisms include possible distortion of the microvasculature by swollen fat-laden hepatocytes, and enhanced production of several cytokines. The beneficial effects of Wy-14,643 may be exerted by dampening adhesion molecule and cytokine responses, and activating NF-[kappa]B, IL-6 production, and p38 kinase to effect cell cycle entry. (HEPATOLOGY 2009.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3238526 Mon, 09 Nov 2009 00:00:00 +0100 3238526 http://www.medworm.com/index.php?rid=3174671&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23421 Conclusion: Ghrelin exerts antifibrotic effects in the liver and may represent a novel antifibrotic therapy. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3174671 Mon, 09 Nov 2009 00:00:00 +0100 3174671 http://www.medworm.com/index.php?rid=3148239&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23422 No abstract. (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3148239 Mon, 09 Nov 2009 00:00:00 +0100 3148239 http://www.medworm.com/index.php?rid=3135000&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23419 Conclusion: Short-term treatment with HSC-targeted losartan markedly reduces advanced liver fibrosis. This approach may provide a novel means to treat chronic liver diseases. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3135000 Mon, 09 Nov 2009 00:00:00 +0100 3135000 http://www.medworm.com/index.php?rid=3134999&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23424 Conclusion: This retrospective analysis demonstrated that HBeAg-negative CHB patients treated with entecavir responded similarly irrespective of baseline ALT level. However, HBeAg-positive patients with mildly elevated ALT responded less well to treatment with entecavir than did those with ALT greater than 2 × ULN. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3134999 Mon, 09 Nov 2009 00:00:00 +0100 3134999 http://www.medworm.com/index.php?rid=3126067&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23418 No abstract. (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3126067 Mon, 09 Nov 2009 00:00:00 +0100 3126067 http://www.medworm.com/index.php?rid=2979996&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23323 Conclusion: The lamivudine-induced virologic response was durable in patients under 40 years old and those receiving lamivudine for more than 12 months after HBeAg clearance or seroconversion. Age and additional treatment were major predictive factors for SVR. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=2979996 Mon, 09 Nov 2009 00:00:00 +0100 2979996 http://www.medworm.com/index.php?rid=2979995&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23321 Conclusion: TASH occurred frequently in these nonobese VC workers with high cumulative exposures and normal liver enzymes. Elevated total cytokeratin 18 suggested the presence of necrotic cell death in TASH and may be a useful serologic biomarker. TASH was further characterized by insulin resistance, elevated proinflammatory cytokines, and impaired antioxidant defenses. The threshold VC exposure and the role of other chemical agents in TASH are as yet unknown. (HEPATOLOGY 2009.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=2979995 Mon, 09 Nov 2009 00:00:00 +0100 2979995 http://www.medworm.com/index.php?rid=2979994&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23383 No abstract. (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=2979994 Mon, 09 Nov 2009 00:00:00 +0100 2979994 http://www.medworm.com/index.php?rid=2962217&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23367 Hepatic encephalopathy (HE) constitutes a neuropsychiatric syndrome which remains a major clinical problem in patients with cirrhosis. In the severest form of HE, cirrhotic patients may develop varying degrees of confusion and coma. Ammonia has been regarded as the key precipitating factor in HE, and astrocytes have been the most commonly affected cells neuropathologically. Although the evidence base supporting a pivotal role of ammonia is robust, in everyday clinical practice a consistent correlation between the concentration of ammonia in the blood and the manifest symptoms of HE is not observed. More recently the synergistic role of inflammation and infection in modulating the cerebral effects of ammonia has been shown to be important. Furthermore, it has been recognized that infection ... Hepatology journals http://www.medworm.com/rss/comments.php?id=2962217 Thu, 05 Nov 2009 00:00:00 +0100 2962217 http://www.medworm.com/index.php?rid=2957829&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23286 Conclusion: Terlipressin plus albumin may prolong short-term survival in type 1 HRS. The duration of the response should be considered when making treatment decisions and in the timing of potential liver transplantations. Considering the small number of patients included, the evidence does not allow for treatment recommendations regarding type 2 HRS or any of the remaining treatment comparisons assessed. (HEPATOLOGY 2009.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=2957829 Wed, 04 Nov 2009 00:00:00 +0100 2957829 http://www.medworm.com/index.php?rid=2942436&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23335 Conclusion: This work is first to demonstrate the efficient generation of hepatic endodermal lineage from human iPSCs that exhibits key attributes of hepatocytes, and the potential application of iPSC-derived HE in studying human liver biology. In particular, iPSCs from individuals representing highly polymorphic variants in metabolic genes and different ethnic groups will provide pharmaceutical development and toxicology studies a unique opportunity to revolutionize predictive drug toxicology assays and allow the creation of in vitro hepatic disease models. (HEPATOLOGY 2009.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=2942436 Fri, 30 Oct 2009 00:00:00 +0100 2942436 http://www.medworm.com/index.php?rid=2937766&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23283 Terlipressin plus albumin is an effective treatment for type 1 hepatorenal syndrome (HRS), but approximately only half of the patients respond to this therapy. The aim of this study was to assess predictive factors of response to treatment with terlipressin and albumin in patients with type 1 HRS. Thirty-nine patients with cirrhosis and type 1 HRS were treated prospectively with terlipressin and albumin. Demographic, clinical, and laboratory variables obtained before the initiation of treatment as well as changes in arterial pressure during treatment were analyzed for their predictive value. Response to therapy (reduction in serum creatinine (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=2937766 Thu, 29 Oct 2009 00:00:00 +0100 2937766 http://www.medworm.com/index.php?rid=3132814&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23411 Conclusion: MAT2A and MAT2[beta] genes are induced during HSC activation and are essential for this process. The SAMe level falls, resulting in global DNA hypomethylation. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3132814 Tue, 27 Oct 2009 00:00:00 +0100 3132814 http://www.medworm.com/index.php?rid=3095548&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23410 Conclusion: Huh-7 cells may represent a novel and valuable tool to investigate the role of altered HFE traffic in iron metabolism and pathogenesis of human HFE HC. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3095548 Tue, 27 Oct 2009 00:00:00 +0100 3095548 http://www.medworm.com/index.php?rid=3337514&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23405 Conclusion: PFs are an important and multifunctional nonparenchymal cell population in need of further study. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3337514 Fri, 23 Oct 2009 00:00:00 +0100 3337514 http://www.medworm.com/index.php?rid=3155425&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23406 No abstract. (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3155425 Fri, 23 Oct 2009 00:00:00 +0100 3155425 http://www.medworm.com/index.php?rid=3135001&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23389 Conclusion: We propose that the inhibition of MSC chemotaxis at sites of high adenosine concentration results in localization of MSCs to areas of cellular injury and death in the liver. We speculate that adenosine might initiate the process of differentiation of MSCs into hepatocyte-like cells. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3135001 Fri, 23 Oct 2009 00:00:00 +0100 3135001 http://www.medworm.com/index.php?rid=3132813&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23407 Conclusion: This study presents DBS as a reliable alternative to serum specimens for detecting anti-HCV, quantifying HCV RNA and genotyping HCV. DBS may increase the opportunities for HCV testing and treatment follow-up in hard-to-reach individuals. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3132813 Fri, 23 Oct 2009 00:00:00 +0100 3132813 http://www.medworm.com/index.php?rid=3126074&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23403 Conclusion: Bicarbonate secretion in mouse cholangiocytes involves two differentially regulated activities: Ae2-mediated Cl-/HCO3- exchange and Na+-HCO3- cotransport. (HEPATOLOGY 2009.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3126074 Fri, 23 Oct 2009 00:00:00 +0100 3126074 http://www.medworm.com/index.php?rid=3051266&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23402 No abstract. (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3051266 Fri, 23 Oct 2009 00:00:00 +0100 3051266 http://www.medworm.com/index.php?rid=2918969&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23204 Conclusion: The addition of MMPD to Peg-IFN-alfa-2a and RBV combination therapy did not increase the proportion of nonresponder patients with genotype 1 CHC achieving an SVR. (HEPATOLOGY 2009.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=2918969 Thu, 22 Oct 2009 23:00:00 +0100 2918969 http://www.medworm.com/index.php?rid=3166130&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23391 Conclusion: These findings support the hypothesis that a critical factor in the pathogenesis of alcoholic liver injury is the enhanced ability of rat or impaired ability of mouse to up-regulate BHMT which prevents hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3166130 Thu, 22 Oct 2009 00:00:00 +0100 3166130 http://www.medworm.com/index.php?rid=3126068&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23394 (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3126068 Thu, 22 Oct 2009 00:00:00 +0100 3126068 http://www.medworm.com/index.php?rid=3070112&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23390 Conclusion: Our results have revealed Foxm1b as the first known direct FXR target gene involved in cell cycle regulation and have demonstrated that defective activation of FXR could be an intrinsic defect in aging regenerating livers. Activation of FXR alone is largely able to alleviate age-related liver regeneration defects. These findings highlight FXR as a potential target of drug design for promoting liver regeneration in older subjects. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3070112 Thu, 22 Oct 2009 00:00:00 +0100 3070112 http://www.medworm.com/index.php?rid=3055372&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23395 No abstract. (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3055372 Thu, 22 Oct 2009 00:00:00 +0100 3055372 http://www.medworm.com/index.php?rid=3051269&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23393 No abstract. (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3051269 Thu, 22 Oct 2009 00:00:00 +0100 3051269 http://www.medworm.com/index.php?rid=3051268&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23387 Conclusion: Our data reveal the unexpected finding that RA signaling positively regulates the wnt2bb gene expression required for liver specification in medaka. These results suggest that a common molecular mechanism may underlie liver and pectoral fin specification during piscine embryogenesis. (HEPATOLOGY 2009.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3051268 Thu, 22 Oct 2009 00:00:00 +0100 3051268 http://www.medworm.com/index.php?rid=3051267&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23397 No abstract. (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3051267 Thu, 22 Oct 2009 00:00:00 +0100 3051267 http://www.medworm.com/index.php?rid=2911204&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23206 Conclusion: Adding metformin to peginterferon and ribavirin was safe and improved insulin sensitivity. Although the study failed to show a statistically significant difference between arms, it did show an improved SVR in females. (HEPATOLOGY 2009.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=2911204 Tue, 20 Oct 2009 23:00:00 +0100 2911204 http://www.medworm.com/index.php?rid=2907663&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23273 Conclusion: Th17 cells are highly enriched in both peripheral blood and liver of CHB patients, and exhibit a potential to exacerbate liver damage during chronic HBV infection. (HEPATOLOGY 2009.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=2907663 Mon, 19 Oct 2009 23:00:00 +0100 2907663 http://www.medworm.com/index.php?rid=3257715&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23381 Conclusion: These data indicate that IL-6 can regulate the activity of DNMT-1 and expression of methylation-dependent tumor suppressor genes by modulation of miR-148a and miR-152, and provide a link between this inflammation-associated cytokine and oncogenesis in cholangiocarcinoma. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3257715 Mon, 19 Oct 2009 00:00:00 +0100 3257715 http://www.medworm.com/index.php?rid=3132815&cid=s_33634_49_f&fid=33634&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fhep.23386 Conclusion: Estrogens stimulate IL-6 production in non-neoplastic female BECs and in neoplastic BECs expressing ER[alpha]. An association between these signaling pathways was demonstrated for female-predominant polycystic livers and might also influence autoimmune hepatitis, primary biliary cirrhosis, and cholangiocarcinogenesis. (HEPATOLOGY 2010.) (Source: Hepatology) Hepatology journals http://www.medworm.com/rss/comments.php?id=3132815 Mon, 19 Oct 2009 00:00:00 +0100 3132815