MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Herpes' source. Sat, 20 Mar 2010 14:27:49 +0100 http://www.medworm.com/index.php?rid=3045344&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19946201%26dopt%3DAbstract We report on a case with DIHS-like symptoms following human herpes virus 6 (HHV-6) infection complicated with encephalopathy. Case Summary: An 11-month-old girl suffered from a human herpes virus 6 (HHV-6) infection (exanthema subitum) complicated with encephalopathy. We treated the patient with continuous infusion of thiopental, assisted mechanical ventilation, methylprednisolone pulse therapy, and gamma-globulin infusion therapy starting on the fifth day of the illness and started phenobarbital administration on the eleventh day. The patient developed a fever, systemic erythematous exanthema, lymphadenopathy, and eosinophilia two weeks after the start of phenobarbital administration. Steroid therapy, methylprednisolone (4mg/kg/day) followed by oral prednisolone (1mg/kg/day), was started ... Herpes journals http://www.medworm.com/rss/comments.php?id=3045344 Wed, 02 Dec 2009 04:36:08 +0100 3045344 http://www.medworm.com/index.php?rid=3028507&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19929384%26dopt%3DAbstract CONCLUSIONS: Our prospective study provides an overview of the clinical and etiologic patterns of acute infectious encephalitis in adults in France. Herpes simplex virus 1 remains the main cause of encephalitis, but bacteria accounts for the highest case-fatality rates. PMID: 19929384 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=3028507 Thu, 26 Nov 2009 15:18:05 +0100 3028507 http://www.medworm.com/index.php?rid=3013198&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19919304%26dopt%3DAbstract Authors: Richter ER, Dias JK, Gilbert Ii JE, Atherton SS The distribution of the neurotropic alphaherpesviruses-herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) and varicella zoster virus (VZV)-was determined in autonomic and sensory ganglia of the head and neck obtained from formalin-fixed human cadavers. HSV-1 and VZV DNA were found in 18 of 58 and 16 of 58 trigeminal, 23 of 58 and 11 of 58 pterygopalatine, 25 of 60 and 14 of 60 ciliary, 25 of 48 and 11 of 48 geniculate, 15 of 50 and 8 of 50 otic, 14 of 47 and 4 of 47 submandibular, 18 of 58 and 10 of 58 superior cervical, and 12 of 36 and 1 of 36 nodose ganglia, respectively. HSV-2 was not detected at any site. Viral DNA positivity and location were independently distributed among autonomic and sensory ganglia of the human hea... Herpes journals http://www.medworm.com/rss/comments.php?id=3013198 Sat, 21 Nov 2009 01:48:06 +0100 3013198 http://www.medworm.com/index.php?rid=3004820&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19911990%26dopt%3DAbstract Conclusions. These are the first prospective data obtained from homosexual men to assess circumcision status as a risk factor for STIs. Circumcised men were at reduced risk of incident syphilis but no other prevalent or incident STIs. Circumcision is unlikely to have a substantial public health impact in reducing acquisition of most STIs in homosexual men. PMID: 19911990 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=3004820 Thu, 19 Nov 2009 05:36:08 +0100 3004820 http://www.medworm.com/index.php?rid=3004819&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19917204%26dopt%3DAbstract Conclusion: The burden of T. vaginalis infection at 8.5% is relatively high among a community sample of young reproductive aged women. Because this infection increases the risk of HIV transmission and is associated with adverse pregnancy outcomes, there is a need for increased screening and treatment of this easily curable sexually transmissible infection in India. PMID: 19917204 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=3004819 Thu, 19 Nov 2009 05:36:05 +0100 3004819 http://www.medworm.com/index.php?rid=2903034&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19832804%26dopt%3DAbstract Conclusions: This study showed that the prevalence of HCMV and HSV viruses in GCF is higher in patients suffering from periodontitis compared to periodontally healthy subjects, and that the prevalence of HCMV is higher in deep periodontal pockets. It also brought evidences that periodontal therapy may be associated with virus elimination in diseased sites. PMID: 19832804 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2903034 Sun, 18 Oct 2009 18:18:05 +0100 2903034 http://www.medworm.com/index.php?rid=2825450&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19773080%26dopt%3DAbstract CONCLUSIONS: Our preliminary experience in Chinese patients indicated that bortezomib-dexamethasone-thalidomide is highly effective in newly-diagnosed MM. Grade three and 4 toxicities are rare after median 2 cycles of therapy. The relative lower rates of neuropathy and DVT/PE in the Chinese patients with MM are being cautiously observed. PMID: 19773080 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2825450 Thu, 24 Sep 2009 15:08:05 +0100 2825450 http://www.medworm.com/index.php?rid=2738530&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19702559%26dopt%3DAbstract Authors: Cheung TC The maintenance of T cell homeostasis requires balance of both positive and negative regulatory signals of T cell proliferation. The herpesvirus entry mediator (HVEM) is a TNF superfamily member, which provides a stimulatory signal when binding LIGHT on T cells. Interestingly, HVEM also engages B and T lymphocyte attenuator (BTLA), an Ig superfamily member that provides an inhibitory signal to T cells. HVEM may act as a molecular switch between positive and inhibitory cosignaling in T cells. Substantial evidence from mouse models and human diseases indicate that the dysregulation of the LIGHT-HVEM-BTLA cosignaling pathway initiates inflammation in the lung and mucosal tissues. Moreover, the targeting of the LIGHT-HVEM-BTLA system by both human cytomegalovirus (CMV) a... Herpes journals http://www.medworm.com/rss/comments.php?id=2738530 Fri, 28 Aug 2009 01:54:07 +0100 2738530 http://www.medworm.com/index.php?rid=2738529&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19702997%26dopt%3DAbstract Authors: Arkin LM, Castelo-Soccio L, Kovarik C PMID: 19702997 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2738529 Fri, 28 Aug 2009 01:54:05 +0100 2738529 http://www.medworm.com/index.php?rid=2731064&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19700894%26dopt%3DAbstract CONCLUSION: The findings of this study provide information on the types and prevalence of oral lesions among Saudi dental patients. This provides baseline data for future studies about the prevalence of oral lesions in the general population. PMID: 19700894 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2731064 Wed, 26 Aug 2009 05:50:04 +0100 2731064 http://www.medworm.com/index.php?rid=2723061&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19691624%26dopt%3DAbstract Authors: Johnson RW, McElhaney J Postherpetic neuralgia (PHN) is the most common complication of herpes zoster (HZ) or 'shingles' and affects a significant proportion of HZ patients with the disease, with the elderly being most frequently and seriously affected. Characterised by various types of pain (constant, intermittent and stimulus evoked) that persist between 3 months and many years after the resolution of the HZ rash, PHN can have a severe impact on the patient's quality of life and functional ability. PHN remains highly resistant to current treatments. In this review, we discuss the epidemiology, clinical features and management of PHN in the elderly and the potential of vaccination against varicella zoster virus as a means to prevent HZ, and thus decrease the incidence and sev... Herpes journals http://www.medworm.com/rss/comments.php?id=2723061 Sat, 22 Aug 2009 13:42:08 +0100 2723061 http://www.medworm.com/index.php?rid=2723060&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19695487%26dopt%3DAbstract Authors: Lisco A, Vanpouille C, Margolis L PMID: 19695487 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2723060 Sat, 22 Aug 2009 13:42:05 +0100 2723060 http://www.medworm.com/index.php?rid=2716698&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19689858%26dopt%3DAbstract CONCLUSION: Early diagnosis of neurological disorders in HIV-infected children is important for appropriate investigation and management, especially the introduction of HAART. PMID: 19689858 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2716698 Thu, 20 Aug 2009 17:38:05 +0100 2716698 http://www.medworm.com/index.php?rid=2709755&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19685309%26dopt%3DAbstract Authors: Kanno A, Ozawa T, Umezawa Y For nondestructive analysis of chemical processes in living mammalian cells, here we show a new reporter gene assay for detecting Ras-Raf-1 interactions based on protein splicing of transcription factors with DnaE inteins. The protein splicing induces connection of a DNA-binding protein (modified LexA; mLexA) with a transcription activation domain of a herpes simplex virus protein (VP16AD). Ras is connected with N-terminal DnaE and mLexA, while Raf-1 is connected with C-terminal DnaE and VP16AD. Upon stimulation with EGF, the interaction between Ras and Raf-1 triggers folding of the DnaEs, thereby inducing protein splicing to form mLexA-VP16AD fusion protein and transcription of a reporter gene, firefly luciferase. The extent of Ras-Raf-1 interactio... Herpes journals http://www.medworm.com/rss/comments.php?id=2709755 Tue, 18 Aug 2009 21:34:02 +0100 2709755 http://www.medworm.com/index.php?rid=2704172&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19679612%26dopt%3DAbstract Authors: Lam FC, Law A, Wykes W PMID: 19679612 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2704172 Mon, 17 Aug 2009 01:30:03 +0100 2704172 http://www.medworm.com/index.php?rid=2704171&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19680456%26dopt%3DAbstract CONCLUSION: In this study, the frequency of total and subclinical HSV-2 shedding was greater than reported in earlier studies involving subjects with a history of symptomatic genital recurrences. Our study is the first to demonstrate a significant reduction in viral shedding with valacyclovir 1 g daily compared to placebo in a population of subjects newly diagnosed with HSV-2 infection. PMID: 19680456 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2704171 Mon, 17 Aug 2009 01:30:03 +0100 2704171 http://www.medworm.com/index.php?rid=2692804&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19663188%26dopt%3DAbstract CONCLUSION: IL-10 hyperproduction observed in recurrent herpetic infection may contribute to progression of rheumatoid arthritis. PMID: 19663188 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2692804 Thu, 13 Aug 2009 08:28:03 +0100 2692804 http://www.medworm.com/index.php?rid=2692803&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19667028%26dopt%3DAbstract CONCLUSIONS: Similar to Cox's relative hazard estimator, the proposed RT does not assume the data are generated from a particular distribution. RTs should be more widely used as a measure of association in clinical trials. Clinical Trials 2009; 6: 320-328. http://ctj.sagepub.com. PMID: 19667028 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2692803 Thu, 13 Aug 2009 08:28:03 +0100 2692803 http://www.medworm.com/index.php?rid=2692802&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19669856%26dopt%3DAbstract This study represents an in vivo indication that this treatment should be further considered as an effective alternative to therapeutic regimens for herpes labialis lesions. PMID: 19669856 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2692802 Mon, 10 Aug 2009 23:00:00 +0100 2692802 http://www.medworm.com/index.php?rid=2692801&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19670385%26dopt%3DAbstract Authors: Srinivasan S, Ahn G, Anderson A Herpes zoster ophthalmicus is a known complication of herpes zoster and the most common manifestation of cranial zoster, accounting for a significant number of zoster cases.1 An uncommon but serious complication of herpes zoster ophthalmicus is zoster meningoencephalitis. The exact incidence of herpes zoster meningoencephalitis is not known; in 1 series, 5.5% of patients who initially presented with ophthalmic zoster had neurological complications.2 Here we report a case of herpes zoster meningoencephalitis in a patient with herpes zoster ophthalmicus. Journal of Hospital Medicine 2009;4:E19-E22. (c) 2009 Society of Hospital Medicine. PMID: 19670385 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2692801 Sun, 09 Aug 2009 23:00:00 +0100 2692801 http://www.medworm.com/index.php?rid=2561798&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19559173%26dopt%3DAbstract CONCLUSIONS: HSV-2 meningitis presents most often without a history of genital herpes, recurrent meningitis, or genital symptoms. Current management practices are highly variable and may lead to unnecessary hospitalization and prolonged intravenous therapy. PMID: 19559173 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2561798 Tue, 30 Jun 2009 23:00:00 +0100 2561798 http://www.medworm.com/index.php?rid=2561797&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19560105%26dopt%3DAbstract Authors: Honjo K, van Reekum R, Verhoeff NP Infection with several important pathogens could constitute risk factors for cognitive impairment, dementia, and Alzheimer's disease (AD) in particular. This review summarizes the data related to infectious agents that appear to have a relationship with AD. Infections with herpes simplex virus type 1, picornavirus, Borna disease virus, Chlamydia pneumoniae, Helicobacter pylori, and spirochete were reported to contribute to the pathophysiology of AD or to cognitive changes. Based on these reports, it may be hypothesized that central nervous system or systemic infections may contribute to the pathogenesis or pathophysiology of AD, and chronic infection with several pathogens should be considered a risk factor for sporadic AD. If this hypothesis... Herpes journals http://www.medworm.com/rss/comments.php?id=2561797 Tue, 30 Jun 2009 23:00:00 +0100 2561797 http://www.medworm.com/index.php?rid=2561796&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19561431%26dopt%3DAbstract A PHASE I-II STUDY OF LIVE ATTENUATED VARICELLA-ZOSTER VIRUS VACCINE TO BOOST IMMUNITY IN HUMAN IMMUNODEFICIENCY VIRUS-INFECTED CHILDREN WITH PREVIOUS VARICELLA. Pediatr Infect Dis J. 2009 Jul;28(7):653-655 Authors: Gershon AA, Levin MJ, Weinberg A, Song LY, Larussa PS, Steinberg SP, Bartlett P, Herpes zoster, may be severe and recurrent in HIV-infected children. We determined the safety and immunogenicity of live attenuated varicella-zoster virus (VZV) vaccine in 46 HIV-infected children who had experienced varicella. There were no serious adverse events. Two years after vaccination 82% of subjects remained VZV-antibody positive and 60% had VZV-specific cell-mediated immunity. No child developed herpes zoster. PMID: 19561431 [PubMed - as supplied by publisher] (Source: He... Herpes journals http://www.medworm.com/rss/comments.php?id=2561796 Tue, 30 Jun 2009 23:00:00 +0100 2561796 http://www.medworm.com/index.php?rid=2561795&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19562216%26dopt%3DAbstract Authors: Hastings G, Krug P, Wang R, Guo J, Lamichhane HP, Tang T, Hsu YS, Ward J, Katz D, Hilliard J FTIR microscopy has been used to collect spectra for uninfected (mock) Vero cells, and cells that have been infected with herpes simplex virus type 1 (HSV-1) and human adenovirus type 5 (Ad-5). Cells were infected at a multiplicity of infection of 10, and studied at 24 hours post exposure. The spectra for infected samples display many differences compared to the spectra for uninfected samples. To estimate how well the spectra for uninfected and infected samples could be discriminated, we used logistic and partial least squares regression methods. We show that the spectra for HSV-1 and mock infected samples are well differentiated and, for a sensitivity of 95%, we calculate a specificit... Herpes journals http://www.medworm.com/rss/comments.php?id=2561795 Tue, 30 Jun 2009 23:00:00 +0100 2561795 http://www.medworm.com/index.php?rid=2561794&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19564286%26dopt%3DAbstract CONCLUSIONS: The prevalence of each STI among sexually victimized children is <10%, even when highly sensitive detection methods are used. Most children with STIs have normal or nonspecific findings on physical examination. PMID: 19564286 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2561794 Tue, 30 Jun 2009 23:00:00 +0100 2561794 http://www.medworm.com/index.php?rid=2534127&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Herpes%29%2520AND%2520%25222009%252F04%252F08%252007.50%2522%255BMHDA%255D%253A%25222009%252F06%252F27%252013.38%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Herpes%2522%255BTIAB%255D%2520OR%2520%2522herpes%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222009%252F04%252F08%252007.50%2522%255BEDAT%255D%29%29 346 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Herpes These pubmed results were generated on 2009/06/27PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2534127 Sat, 27 Jun 2009 17:38:02 +0100 2534127 http://www.medworm.com/index.php?rid=2264447&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19276657%26dopt%3DAbstract Authors: Hodish I, Tal R, Shaish A, Varda-Bloom N, Greenberger S, Rauchwerger A, Breitbart E, Bangio L, Ben-Shushan D, Pfeffer R, Feder B, Waitsman A, Barshack I, Goldberg I, Mazaki-Tovi S, Peled M, Harats D Transcription-targeted gene delivery directed against angiogenic endothelial cells is a new approach against advanced cancer. Moreover, the herpes simplex virus-thymidine kinase (HSV-TK) gene coupled with low dose radiotherapy is an efficient and externally controlled cytotoxic system. We have previously demonstrated enhanced endothelial-specific cell expression and killing using the modified murine pre-proendothelin-1 promoter (PPE1-3x) to direct adenoviral expression of a pro-apoptotic gene. The purpose of this study was to create an externally potentiated systemic anti-antiangio... Herpes journals http://www.medworm.com/rss/comments.php?id=2264447 Sun, 15 Mar 2009 04:23:50 +0100 2264447 http://www.medworm.com/index.php?rid=2238543&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19263508%26dopt%3DAbstract Authors: Rashid ZM, Lahaye E, Defer D, Douzenel P, Perrin B, Bourgougnon N, Sire O Exopolysaccharides (EPS) were extracted from a sponge, Celtodoryx girardae recently discovered in the Golfe du Morbihan in 2000. Sponge samples were collected monthly from November 2007 to May 2008. SEC analysis of EPS samples showed that they exhibit a unique molecular weight of approximately 800 kDa. However, infrared analysis revealed that structural seasonal variations occur. EPS fractions also exhibit significant sulphate contents and were screened in vitro for a potential antiviral activity against Herpes simplex virus type 1 (HSV-1). The best result was obtained with a sample collected in January which exhibits an EC(50) of 5.9 microg/mL without cytotoxicity on the Vero cell line. Experiments carr... Herpes journals http://www.medworm.com/rss/comments.php?id=2238543 Fri, 06 Mar 2009 19:47:56 +0100 2238543 http://www.medworm.com/index.php?rid=2221033&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19239344%26dopt%3DAbstract Authors: Drew WL PMID: 19239344 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2221033 Sat, 28 Feb 2009 14:36:47 +0100 2221033 http://www.medworm.com/index.php?rid=2221032&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19239804%26dopt%3DAbstract Authors: Delany-Moretlwe S, Lingappa JR, Celum C Herpes simplex type 2 (HSV-2) infection is common and frequently asymptomatic. Concerns exist about the high prevalence of HSV-2, particularly in areas of high HIV prevalence, because of observations that HSV-2 is associated with an increased risk of HIV acquisition, transmission, and disease progression. Several randomized trials have tested or are testing whether HSV-2 treatment can limit the spread of HIV, with mixed results. Although treatment with acyclovir, 400 mg twice daily, does not reduce HIV incidence, suppressive acyclovir and valacyclovir reduce HIV levels in plasma and in the genital tract. Ongoing trials are evaluating whether HSV suppression will reduce HIV transmission and disease progression. Until a protective HSV-2 or... Herpes journals http://www.medworm.com/rss/comments.php?id=2221032 Sat, 28 Feb 2009 14:36:43 +0100 2221032 http://www.medworm.com/index.php?rid=2221031&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19243374%26dopt%3DAbstract CONCLUSIONS: High levels of unsafe sex and many important sexual health problems were identified which provide direction for public health interventions for older sexually active Australians. PMID: 19243374 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2221031 Sat, 28 Feb 2009 14:36:37 +0100 2221031 http://www.medworm.com/index.php?rid=2221030&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19244049%26dopt%3DAbstract Conclusion: Dual-modality imaging permits complementary information in regard to cell survival and proliferation, graft formation, and effects on cardiac function. Supplemental material: http://radiology.rsnajnls.org/cgi/content/full/250/3/821/DC1 (c) RSNA, 2009. PMID: 19244049 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2221030 Sat, 28 Feb 2009 14:36:31 +0100 2221030 http://www.medworm.com/index.php?rid=2221029&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19245354%26dopt%3DAbstract This article will examine the current recommendations for diagnosis using serologic and viral detection techniques. Treatment options for initial and recurrent genital herpes infection in pregnancy are reviewed. The use of prophylactic antivirals and cesarean delivery are discussed. The article concludes with a look to the future, including potential changes in the management of herpes simplex virus-infected pregnant women. PMID: 19245354 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2221029 Sat, 28 Feb 2009 14:36:27 +0100 2221029 http://www.medworm.com/index.php?rid=2221028&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19245595%26dopt%3DAbstract We describe an 89-year-old human immunodeficiency virus (HIV)-negative male patient with HHV8-unrelated PEL-like lymphoma in the pleura. No hepatosplenomegaly or lymphadenopathy was detected. Chest radiography and computed tomography revealed right pleural effusion, but no evidence of tumor mass or lymph node enlargement. Cytological analysis of the pleural effusion revealed a high-grade lymphoma with round nuclei, prominent nucleoli and abundant cytoplasm with immunophenotypes positive for CD45, CD30, CD38, CD7 and CD71. Because of the advanced age, no chemotherapy was given. Effusion resolved spontaneously. One year after the diagnosis, a new pleural effusion developed at the left side. Following thoracentesis and pleurodesis, the patient remained in complete remission for 40 months. To ... Herpes journals http://www.medworm.com/rss/comments.php?id=2221028 Sat, 28 Feb 2009 14:36:22 +0100 2221028 http://www.medworm.com/index.php?rid=2215113&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19237800%26dopt%3DAbstract Authors: Chandravanshi SL, Rathore MK PMID: 19237800 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2215113 Thu, 26 Feb 2009 12:28:18 +0100 2215113 http://www.medworm.com/index.php?rid=2194063&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19218200%26dopt%3DAbstract Authors: Liljeqvist JA, Tunbäck P, Norberg P Herpes simplex virus type 1 (HSV-1) is a ubiquitous pathogen infecting most individuals worldwide. The majority of HSV-1-infected individuals have no clinical symptoms but shed HSV-1 asymptomatically in saliva. Recent phylogenetic analyses of HSV-1 have defined three genetic clades (A-C) and recombinants thereof. These data have all been based on clinical HSV-1 isolates and do not cover genetic variation of asymptomatically shed HSV-1. The primary goal of this study was to investigate such variation. A total of 648 consecutive saliva samples from five HSV-1-infected volunteers was collected. Asymptomatic shedding was detected on 7.6 % of the days from four subjects. The HSV-1 genome loads were quantified with real-time PCR and varied fr... Herpes journals http://www.medworm.com/rss/comments.php?id=2194063 Wed, 18 Feb 2009 13:23:22 +0100 2194063 http://www.medworm.com/index.php?rid=2194062&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19218765%26dopt%3DAbstract Authors: Shoji H PMID: 19218765 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2194062 Wed, 18 Feb 2009 13:23:08 +0100 2194062 http://www.medworm.com/index.php?rid=2194066&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19216628%26dopt%3DAbstract Conclusions: The addition of rituximab to CHOP chemotherapy did not improve outcome in early-stage PGL. PMID: 19216628 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2194066 Fri, 13 Feb 2009 05:00:00 +0100 2194066 http://www.medworm.com/index.php?rid=2194065&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19216681%26dopt%3DAbstract Authors: Ryan DA, Federoff HJ Over two decades have passed since the initial technology was created to develop recombinant herpes simplex viruses (Meignier et al., 1988; Post and Roizman, 1981; Roizman and Jenkins, 1985). Since that time, herpes simplex viruses have been engineered into amenable tools for gene therapy. There are a wide range of herpes simplex virus (HSV) based vector platforms and packaging strategies, which are continually being improved to fit the needs of a particular application. In this review, we will present the biology of HSV, explore various HSV based vectors utilized in gene therapeutic approaches, and the severity of their ensuing innate and adaptive immune responses. PMID: 19216681 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2194065 Fri, 13 Feb 2009 05:00:00 +0100 2194065 http://www.medworm.com/index.php?rid=2194064&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19217041%26dopt%3DAbstract This report presents seven Japanese cases of PEL. In situ hybridization revealed that the PEL cells were negative for EBV in all cases. An immunocytological analysis showed that only one case was positive for HHV-8, and PEL cells were positive for CD20 in all cases. MUM1 was positive, but CD10 and CD138 were negative in six cases. One case each was positive for CD30 and BCL-6. The phenotypic patterns of HIV-related is BCL6-/MUM1+/CD138+, thus, the phenotypic findings observed by immunocytochemistry in this study were somehow different from those reported in Western countries. However, the cytomorphological features of PEL cells showed large cell size, abundant basophilic cytoplasm, coarse chromatin, and occasional binucleated or multinucleated cells, similar to a large cell immunoblastic a... Herpes journals http://www.medworm.com/rss/comments.php?id=2194064 Fri, 13 Feb 2009 05:00:00 +0100 2194064 http://www.medworm.com/index.php?rid=2186482&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19211591%26dopt%3DAbstract CONCLUSIONS: HIV prevalence in Pakistan remains low, however emergence of genital herpes is a matter of concern as it could lead to a future conduit for HIV spread. Health education messages should target less educated segments of society and specifically advocate safe sex practices and early diagnosis. PMID: 19211591 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2186482 Wed, 11 Feb 2009 05:00:00 +0100 2186482 http://www.medworm.com/index.php?rid=2186481&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19211592%26dopt%3DAbstract CONCLUSIONS: This study suggests that intent does not always predict behaviour even when the two are measured within close temporal proximity. There are factors that may predict intent only or behavior only, or may predict behavior, but solely through influencing intent. Understanding how these various relationships work may be important to efforts designed to maximize acceptance of HSV-2 testing. PMID: 19211592 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2186481 Wed, 11 Feb 2009 05:00:00 +0100 2186481 http://www.medworm.com/index.php?rid=2186480&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19211593%26dopt%3DAbstract CONCLUSIONS: Most HSV-2 seropositive persons shed HSV from the genital mucosa. Dichotomization of persons into "shedders" and "nonshedders" or "high" and "low" shedders yields inferences that depend upon sampling interval length. Overall shedding rates provide consistent measures regardless of the number of swabs collected. PMID: 19211593 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2186480 Wed, 11 Feb 2009 05:00:00 +0100 2186480 http://www.medworm.com/index.php?rid=2186479&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19211749%26dopt%3DAbstract In this report we show that ORF61p, the Varicella Zoster Virus (VZV) ortholog, does not degrade PML and only slightly alters Sp100 levels. Furthermore, we demonstrate that other virus proteins cannot substitute for this lack of function during infection. By use of short interfering RNAs we depleted PML, Sp100 and Daxx and studied their role in plaquing efficiency, virus protein accumulation, infectious center titer and virus spread. These studies show that components of ND10s can accelerate VZV replication but do not ultimately control cell-associated virus titers. We conclude that while both ICP0 and ORF61p activate virus gene expression, they modulate host innate repression mechanisms in two different ways. As a result HSV and VZV commandeer their hosts by distinct mechanisms to ensure t... Herpes journals http://www.medworm.com/rss/comments.php?id=2186479 Wed, 11 Feb 2009 05:00:00 +0100 2186479 http://www.medworm.com/index.php?rid=2186478&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19211753%26dopt%3DAbstract In conclusion, the large accumulation of LAT and cytotoxic T-cells in the V2 and V3 but not in the V1 division of the TG reflects the sites supplied by the sensory fibers and the clinical reactivation patterns. PMID: 19211753 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2186478 Wed, 11 Feb 2009 05:00:00 +0100 2186478 http://www.medworm.com/index.php?rid=2186477&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19213040%26dopt%3DAbstract CONCLUSIONS:: These data suggest that FGF2-retargeted Ad-TK produces a combination of expected direct antitumor cytotoxicity and a newly reported antiangiogenesis effect that could prove promising as a novel therapeutic approach in the treatment of FGF receptor-expressing cancers. Laryngoscope, 2009. PMID: 19213040 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2186477 Wed, 11 Feb 2009 05:00:00 +0100 2186477 http://www.medworm.com/index.php?rid=2186476&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19213041%26dopt%3DAbstract Authors: Eskiizmir G, Uz U, Taşkiran E, Unlü H Ramsay-Hunt syndrome, herpes zoster oticus (HZO), derived its name from James Ramsay Hunt, who first described it in 1907. It is classically characterized by acute peripheral facial paralysis, herpetic eruptions on the auricle, and vestibulocochlear dysfunction due to the reactivation of varicella zoster virus (VZV). In this Case Report, the authors describe an HZO patient with simultaneous VZV encephalitis. To date, only eight cases of HZO associated with VZV encephalitis have been reported in the English literature. Therefore, the authors discuss all the aspects of this rare entity, including clinical examination, radiological evaluation, laboratory evaluation, and treatment options. Laryngoscope, 2009. PMID: 19213041 [Pub... Herpes journals http://www.medworm.com/rss/comments.php?id=2186476 Wed, 11 Feb 2009 05:00:00 +0100 2186476 http://www.medworm.com/index.php?rid=2186475&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19215952%26dopt%3DAbstract Authors: Rogers KM, Deatheridge M, Breshears MA, Chapman S, Black D, Ritchey JW, Payton M, Eberle R Isolates of baboon alpha-herpesvirus Papiine herpesvirus 2 (HVP2) exhibit one of two distinct phenotypes in mice: extremely neurovirulent or apathogenic. Previous studies implicated the type I interferon (IFN) response as being a major factor in controlling infection by apathogenic isolates. To further investigate the possibility that the host IFN-beta response underlies the pathogenicity of the two HVP2 subtypes, the susceptibility of mice lacking the IFN-beta receptor (IFNAR(-/-)) to infection was examined. Apathogenic isolates of HVP2 (HVP2ap) replicated in IFNAR(-/-) primary mouse dermal fibroblast (PMDF) cultures as well as neurovirulent (HVP2nv) isolates. IFNAR(-/-) mice were also ... Herpes journals http://www.medworm.com/rss/comments.php?id=2186475 Tue, 10 Feb 2009 05:00:00 +0100 2186475 http://www.medworm.com/index.php?rid=2181181&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19204724%26dopt%3DAbstract In this study we employed a gene therapeutic approach to reduce anxiety and dendritic arborization of the amygdala neurons. Specifically, we overexpressed SK2 potassium channel in the basolateral amygdala using a herpes simplex viral system. Our choice of therapeutic cargo was guided by the indications that activation of the amygdala might underlie anxiety and that SK2 could reduce neuronal activation by exerting inhibitory influence on action potentials. We report that SK2 overexpression reduced anxiety and stress-induced corticosterone secretion at a systemic level. SK2 overexpression also reduced dendritic arborization of the amygdala neurons. Hence, SK2 is a potential gene therapy candidate molecule that can be used against stress-related neuropsychiatric disorders such as anxiety.Mole... Herpes journals http://www.medworm.com/rss/comments.php?id=2181181 Tue, 10 Feb 2009 05:00:00 +0100 2181181 http://www.medworm.com/index.php?rid=2166619&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19192993%26dopt%3DAbstract Conclusion: Treatment with single-day famciclovir for recurrent genital herpes did not shorten the time to the next recurrence. Drug resistance to penciclovir continues to be a rare event in immunocompetent patients. PMID: 19192993 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2166619 Sun, 08 Feb 2009 12:20:18 +0100 2166619 http://www.medworm.com/index.php?rid=2166618&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19197321%26dopt%3DAbstract Authors: Passer BJ, Castelo-Branco P, Buhrman JS, Varghese S, Rabkin SD, Martuza RL Genetically engineered oncolytic herpes simplex virus-1 (HSV-1) vectors selectively replicate in tumor cells causing direct killing whereas sparing normal cells. One clinical limitation of using oncolytic HSV vectors is their attenuated growth. We hypothesized that the appropriately chosen chemotherapeutic agent combined with an oncolytic HSV could be an effective means to promote augmented prostate cancer cell killing both in vitro and in vivo. Here we have identified that G47Delta synergizes with the microtubule-stabilizing taxane agents docetaxel and paclitaxel to enhance the in vitro killing of prostate cancer cells. In vivo efficacy studies show that when combined with docetaxel, G47Delta could be ... Herpes journals http://www.medworm.com/rss/comments.php?id=2166618 Fri, 06 Feb 2009 05:00:00 +0100 2166618 http://www.medworm.com/index.php?rid=2159601&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19188750%26dopt%3DAbstract CONCLUSION: The results suggested that TNF-alpha ASON reduced the content of TNF-alpha in mouse eyes, and this topical treatment decreased the inflammatory reaction. It may be an effective method for treating HSV-1-induced chorioretinitis in the clinic. PMID: 19188750 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2159601 Thu, 05 Feb 2009 06:00:08 +0100 2159601 http://www.medworm.com/index.php?rid=2159603&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19188440%26dopt%3DAbstract Authors: Misaghi S, Ottosen S, Izrael-Tomasevic A, Arnott D, Lamkanfi M, Lee J, Liu J, O'Rourke K, Dixit VM, Wilson AC Protein ubiquitination provides an efficient and reversible mechanism to regulate cell cycle progression and checkpoint control. Numerous regulatory proteins direct the addition of ubiquitin to lysine residues on target proteins and these are countered by an army of deubiquitinating enzymes (DUBs). BRCA1-associated protein-1 (Bap1) is a ubiquitin carboxy-terminal hydrolase and is frequently mutated in lung and sporadic breast tumors. Bap1 can suppress growth of lung cancer cells in athymic nude mice and this requires its DUB activity. Here we show that Bap1 interacts with host cell factor-1 (HCF-1), a transcriptional cofactor found in a number of important regulatory c... Herpes journals http://www.medworm.com/rss/comments.php?id=2159603 Mon, 02 Feb 2009 05:00:00 +0100 2159603 http://www.medworm.com/index.php?rid=2159602&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19188604%26dopt%3DAbstract Authors: Shirtcliff EA, Coe CL, Pollak SD It is well known that children need solicitous parenting and a nurturing rearing environment to ensure their normal behavioral development. Early adversity often negatively impacts emotional and mental well-being, but it is less clearly established how much the maturation and regulation of physiological systems is also compromised. The following research investigated the effect of 2 different types of adverse childhood experiences, early deprivation through institutionalization and physical abuse, on a previously unexplored outcome: the containment of herpes simplex virus (HSV). The presence of HSV-specific antibody in salivary specimens was determined in 155 adolescents, including 41 postinstitutionalized, 34 physically-abused, and 80 demograp... Herpes journals http://www.medworm.com/rss/comments.php?id=2159602 Mon, 02 Feb 2009 05:00:00 +0100 2159602 http://www.medworm.com/index.php?rid=2155655&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19182056%26dopt%3DAbstract This study was undertaken to establish reliable factors in order to identify chlamydial cervicitis among suspicious patients. Between January and December 2007, 406 patients who were suspected to have cervicitis due to clinical symptoms, were tested with polymerase chain reaction (PCR) for Chlamydia trachomatis (CT), vaginal pH and Nugent score (NS) in our University hospital and related clinics. During the same period, 67 patients who were diagnosed as having other sexually transmitted diseases (Neisseria gonorrhoeae (NG), Trichomonas vaginalis, Condyloma acuminatum and genital herpes) were also made to participate in this study. Eighty-nine women (22%) were positive for CT PCR. Bacterial vaginosis (BV)-positive women were tested positive for CT PCR (75/288), significantly higher than tho... Herpes journals http://www.medworm.com/rss/comments.php?id=2155655 Sun, 01 Feb 2009 05:00:00 +0100 2155655 http://www.medworm.com/index.php?rid=2155654&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19182057%26dopt%3DAbstract Authors: He N, Cao H, Yin Y, Gao M, Zhang T, Detels R The overall herpes simplex virus (HSV)-2 seroprevalence was 5.5% among male rural migrants working in construction sites, markets and factories, 5.4% among those reporting having had sexual intercourse and 5.8% among those reporting no sexual intercourse. Multiple logistic regression analyses indicate that migrants having higher income were more likely to have HSV-2 infection. None of the HSV-2-positives realized their infection status. Future sexually transmitted disease (STD) intervention programmes should target migrants with higher income and migrant market vendors and should not exclude those who self-report no STDs or no history of sexual intercourse. PMID: 19182057 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2155654 Sun, 01 Feb 2009 05:00:00 +0100 2155654 http://www.medworm.com/index.php?rid=2155653&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19182063%26dopt%3DAbstract Authors: Jongeling S, Chen MY, Bush MR, Bradshaw CS, Fairley CK The aim of this study is to compare risk factors in new clients attending the walk-in triage-based day clinic (WITS) to those attending a telephone-triage appointment-based evening clinic of a sexual health service. The method involves an audit of computerized medical records of new clients attending between July 2002 and December 2007. There were 37,833 new clients of which 37,223 (98.4%) attended WITS and 610 (1.6%) attended the evening clinic. WITS clients were significantly older (31% vs. 30%, P < 0.041), more likely to be male (58% vs. 43%, P < 0.001), sex workers (6% vs. 3%, P < 0.001), not employed (34% vs. 10%, P < 0.001), diagnosed with gonorrhoea (1.7% vs. 0.7%, P < 0.041), herpes (4% vs. 2%, P &lt... Herpes journals http://www.medworm.com/rss/comments.php?id=2155653 Sun, 01 Feb 2009 05:00:00 +0100 2155653 http://www.medworm.com/index.php?rid=2155652&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19182064%26dopt%3DAbstract Authors: Deko OA, Pakozdi A, Evans DT, Jaleel H A retrospective analysis of patients, who have been on long-term suppressive therapy for recurrent episodes of herpes simplex (HSV) in a university hospital, was performed and the findings were documented and orchestrated into bar graphs. The study involved patients between the years 2000 and 2007, both inclusive. The results were compared with the British Association for Sexual Health and HIV guidelines. Eighty-two percent (57) had had the infection for at least 12 months at the start of therapy and 78.2% (54) had at least six recurrences per year before the start of treatment. Indeed, only four patients (5.8%) had a treatment interruption at 12 months or less; also only 11 patients (15.9%) had less than six outbreaks per year at the sta... Herpes journals http://www.medworm.com/rss/comments.php?id=2155652 Sun, 01 Feb 2009 05:00:00 +0100 2155652 http://www.medworm.com/index.php?rid=2149138&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19179219%26dopt%3DAbstract Authors: Van de Perre P, Nagot N, Mayaud P PMID: 19179219 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2149138 Sun, 01 Feb 2009 04:59:28 +0100 2149138 http://www.medworm.com/index.php?rid=2149137&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19179220%26dopt%3DAbstract Authors: Cheng RG, Nixon DF PMID: 19179220 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2149137 Sun, 01 Feb 2009 04:59:25 +0100 2149137 http://www.medworm.com/index.php?rid=2146795&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19128163%26dopt%3DAbstract Authors: Chang CC, McLean C, Vujovic O, Jenney AJ, Short M, Lyon S, Storey E, Lewin SR PMID: 19128163 [PubMed - indexed for MEDLINE] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2146795 Sat, 31 Jan 2009 05:23:12 +0100 2146795 http://www.medworm.com/index.php?rid=2130755&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19161751%26dopt%3DAbstract CONCLUSIONS: The occurrence of herpes zoster peaks between 12 and 36 months after lung transplantation. Additional immunosuppression may increase the risk. Further studies on preventive strategies against herpes zoster in this population are warranted. PMID: 19161751 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2130755 Sun, 25 Jan 2009 04:56:44 +0100 2130755 http://www.medworm.com/index.php?rid=2127980&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19158558%26dopt%3DAbstract CONCLUSIONS: Microbial keratitis in Down syndrome is associated with eyelid problems and ocular atopy, and due to failure of medical therapy alone, surgical intervention is required in majority of cases. PMID: 19158558 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2127980 Sat, 24 Jan 2009 06:11:03 +0100 2127980 http://www.medworm.com/index.php?rid=2120055&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19153737%26dopt%3DAbstract Authors: Naniwa T, Watanabe M, Banno S, Maeda T In the present study, we retrospectively evaluate the efficacy of low dose tacrolimus (TAC) as add-on therapy in refractory rheumatoid arthritis (RA) despite a combination of tumor necrosis factor (TNF) inhibitor and methotrexate (MTX) using consecutive case series of five patients with active RA (mean disease duration 2.3 years) despite MTX and TNF inhibitors for at least 3 months (mean 9.5 months) treated with low dose TAC (1.5-2 mg/day) for at least 6 months (mean 1.8 years). Clinical and radiographic efficacy was assessed according to the European league against rheumatism response criteria and the modified Sharp method, respectively. At 1 year, three patients reached to remission. The mean yearly progression of radiographic joint dam... Herpes journals http://www.medworm.com/rss/comments.php?id=2120055 Tue, 20 Jan 2009 05:00:00 +0100 2120055 http://www.medworm.com/index.php?rid=2120054&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19153825%26dopt%3DAbstract Authors: Zhao Y, Wang JW, Ma B, Liu F Here, we first present unique short (US)3, US4, and US5 gene sequences, with analysis, of duck enteritis virus (DEV) vaccine strain C-KCE. The assembled sequence comprises 5,742 nucleotides, which are amplified from the DEV genome by single oligonucleotide-nested polymerase chain reaction with primers designed according to our previous acquired sequence deposited in GenBank (accession no. EF619046). The predicted gene arrangement is colinear with the alphaherpesvirus herpes simplex virus within the US region. The N-glycosylated sites, signal peptide, transmembrane helices, RNA polymerase II transcriptional control elements, and polyadenylation signal, were predicted with network prediction programs. Phylogenetic analysis of the three putative prote... Herpes journals http://www.medworm.com/rss/comments.php?id=2120054 Tue, 20 Jan 2009 05:00:00 +0100 2120054 http://www.medworm.com/index.php?rid=2120056&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19153243%26dopt%3DAbstract We examined the contributions of migratory versus lymph node-resident DC populations in antigen presentation to CD4 and CD8 T cells after needle injection, epicutaneous infection, or vaginal mucosal herpes simplex virus (HSV) 1 infection. We show that upon needle injection, HSV-1 became lymph-borne and was rapidly presented by lymph node-resident DCs to CD4 and CD8 T cells. In contrast, after vaginal HSV-1 infection, antigens were largely presented by tissue-derived migrant DCs with delayed kinetics. In addition, migrant DCs made more frequent contact with HSV-specific T cells after vaginal infection compared with epicutaneous infection. Thus, both migrant and resident DCs play an important role in priming CD8 and CD4 T cell responses, and their relative importance depends on the mode of i... Herpes journals http://www.medworm.com/rss/comments.php?id=2120056 Mon, 19 Jan 2009 05:00:00 +0100 2120056 http://www.medworm.com/index.php?rid=2109883&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19145052%26dopt%3DAbstract CONCLUSION: A lower GCS and a higher rate of lesions on CT were identified as predictors of a prolonged course for HSVE. These predictors are in accordance with the conventional predictors of poor outcome for HSVE. This study suggests that the initial ACV treatment was insufficient for HSVE patients with these predictors at the acute stage. The initial treatment may need to be modified for such patients. PMID: 19145052 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2109883 Sat, 17 Jan 2009 05:31:37 +0100 2109883 http://www.medworm.com/index.php?rid=2109885&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19144708%26dopt%3DAbstract Authors: Kassim SH, Rajasagi NK, Ritz BW, Pruett SB, Gardner EM, Chervenak R, Jennings SR Natural killer (NK) cells play an important role in the optimal clearance of herpes simplex type 1 (HSV-1) infection in mice. Activated NK cells function via cytokine secretion or direct cytolysis of target cells; dendritic cells (DCs) are thought to make critical contributions in the activation of both of these functions. Yet, the magnitude and physiological relevance of DC-mediated NK cell activation in vivo is not completely understood. To examine the contribution of DC help in regulating NK cell functions after infection with HSV-1, we utilized a transgenic mouse model that enables for the transient ablation of DCs. Using this approach, it was found that the IFN-gamma expression potential of N... Herpes journals http://www.medworm.com/rss/comments.php?id=2109885 Wed, 14 Jan 2009 05:00:00 +0100 2109885 http://www.medworm.com/index.php?rid=2109884&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19144716%26dopt%3DAbstract Authors: Besecker MI, Harden ME, Li G, Wang XJ, Griffiths A Herpes B virus (BV) naturally infects macaque monkeys and is a close relative of herpes simplex virus. BV can zoonotically infect humans to cause a rapidly ascending encephalitis with approximately 80% mortality. Therefore, BV is a serious danger to those who come into contact with these monkeys, or their tissues and cells. MicroRNAs are regulators of gene expression and there have been reports of virus-encoded microRNAs. We hypothesize that BV-encoded microRNAs are important for the regulation of viral and cellular genes. Herein, we report the discovery of three herpes B virus encoded microRNAs. PMID: 19144716 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2109884 Wed, 14 Jan 2009 05:00:00 +0100 2109884 http://www.medworm.com/index.php?rid=2107095&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19142669%26dopt%3DAbstract CONCLUSION: Lidocaine patch use did not significantly reduce pain intensity ratings or the majority of related secondary end points in cancer patients with persistent incisional pain. PMID: 19142669 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2107095 Tue, 13 Jan 2009 05:00:00 +0100 2107095 http://www.medworm.com/index.php?rid=2103739&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19139952%26dopt%3DAbstract CONCLUSION: SOFS is a rare complication of herpes zoster infection. With the appropriate treatment and follow-up, patients may be reassured that recovery of their visual acuity and ocular motility will occur. PMID: 19139952 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2103739 Tue, 13 Jan 2009 05:00:00 +0100 2103739 http://www.medworm.com/index.php?rid=2103740&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19138471%26dopt%3DAbstract DISCUSSION: Our conclusion is that microglial cells are targets for olomoucine and that modulation of glial response and inflammation may be an appendant mechanism of CDK inhibitor-mediated neuroprotection in HSV-1 encephalitis. PMID: 19138471 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2103740 Fri, 09 Jan 2009 05:00:00 +0100 2103740 http://www.medworm.com/index.php?rid=2086302&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19125064%26dopt%3DAbstract Authors: Hamrah P, Pavan-Langston D, Dana R PMID: 19125064 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2086302 Thu, 08 Jan 2009 05:23:18 +0100 2086302 http://www.medworm.com/index.php?rid=2072347&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19116869%26dopt%3DAbstract We describe in this paper a facile synthesis route for the prodrug and its physicochemical properties. PMID: 19116869 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2072347 Sat, 03 Jan 2009 05:52:53 +0100 2072347 http://www.medworm.com/index.php?rid=2072349&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19114378%26dopt%3DAbstract Conclusions: College health centers are important sources for Pap and STI test data. Pap tests frequently yield low-grade abnormalities, and screening tests for chlamydia and especially gonorrhea are infrequently positive. Rates of HIV and syphilis in this population are low, raising concerns about positive predictive value when screening low-risk students. A majority of genital herpes infections are caused by HSV-1. PMID: 19114378 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2072349 Thu, 01 Jan 2009 05:00:00 +0100 2072349 http://www.medworm.com/index.php?rid=2072348&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19116635%26dopt%3DAbstract Authors: Aghi MK, Chiocca EA PMID: 19116635 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2072348 Thu, 01 Jan 2009 05:00:00 +0100 2072348 http://www.medworm.com/index.php?rid=2066750&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19109159%26dopt%3DAbstract Authors: Jirmo AC, Nagel CH, Bohnen C, Sodeik B, Behrens GM Dendritic cells (DC), which can be subdivided into different phenotypic and functional subsets, play a pivotal role in the generation of cytotoxic T cell immunity against viral infections. Understanding the modes of Ag acquisition, processing and presentation by DC is essential for the design of effective antiviral vaccines. We aimed to assess the contribution of direct vs cross-presentation for the induction of HSV1-specific CD8(+) T lymphocyte responses in mice. Using HSV1 strains expressing fluorescence proteins, we provide evidence for the ability of HSV1 to induce viral transcription. Using HSV1-wild-type as well as gB- or gH-deficient mutants to either directly inoculate DC or to infect target cells, which then were give... Herpes journals http://www.medworm.com/rss/comments.php?id=2066750 Sun, 28 Dec 2008 05:55:46 +0100 2066750 http://www.medworm.com/index.php?rid=2059144&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19098045%26dopt%3DAbstract Authors: Todani A, Gupta P, Colby K PMID: 19098045 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2059144 Wed, 24 Dec 2008 07:44:52 +0100 2059144 http://www.medworm.com/index.php?rid=2055413&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19094835%26dopt%3DAbstract Authors: Walker MF Vestibular neuritis is an acute peripheral vestibulopathy. It is thought to result from a reactivation of herpes simplex virus that affects the vestibular ganglion, vestibular nerve, labyrinth, or a combination of these. The symptoms are prolonged continuous vertigo, nausea and vomiting, and imbalance. In evaluating a patient with an acute vestibular syndrome, it is important not to miss a central cause, such as a brainstem or cerebellar stroke or hemorrhage, which could be life-threatening. Definitive central signs are not always present. Thus, any patient thought to have vestibular neuritis who has significant vascular risk factors should be evaluated for possible stroke. Most patients recover well from vestibular neuritis, even without treatment. Nonetheless, stud... Herpes journals http://www.medworm.com/rss/comments.php?id=2055413 Mon, 22 Dec 2008 05:32:40 +0100 2055413 http://www.medworm.com/index.php?rid=2051263&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19088274%26dopt%3DAbstract Authors: Stow ND, Evans VC, Matthews DA Previous reports have shown that adenovirus recruits nucleolar protein upstream-binding factor (UBF) into adenovirus DNA replication centres. Here, we report that despite having a different mode of viral DNA replication, herpes simplex virus type 1 (HSV-1) also recruits UBF into viral DNA replication centres. Moreover, as with adenovirus, enhanced green fluorescent protein-tagged fusion proteins of UBF inhibit viral DNA replication. We propose that UBF is recruited to the replication compartments to aid replication of HSV-1 DNA. In addition, this is a further example of the role of nucleolar components in viral life cycles. PMID: 19088274 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2051263 Sat, 20 Dec 2008 07:54:17 +0100 2051263 http://www.medworm.com/index.php?rid=2051262&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19088275%26dopt%3DAbstract Authors: Rasmussen SB, Jensen SB, Nielsen C, Quartin E, Kato H, Chen ZJ, Silverman RH, Akira S, Paludan SR The innate antiviral response is initiated by pattern recognition receptors, which recognize viral pathogen-associated molecular patterns. Here we show that retinoic acid-inducible gene (RIG)-I-like receptors (RLRs) in cooperation with Toll-like receptor (TLR) 9 is required for expression of type I interferons (IFNs) after infection with herpes simplex virus (HSV). Our work also identified RNase L as a critical component in IFN induction. Moreover, we found that TLR9 and RLRs activate distinct, as well as overlapping, intracellular signalling pathways. Thus, RLRs are important for recognition of HSV infection, and cooperate with the Toll pathway to induce an antiviral response. ... Herpes journals http://www.medworm.com/rss/comments.php?id=2051262 Sat, 20 Dec 2008 07:54:13 +0100 2051262 http://www.medworm.com/index.php?rid=2051261&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19092420%26dopt%3DAbstract We report the case of a 34-year-old man who had uncomplicated cataract surgery in his left eye. Medical history was significant for atopic dermatitis, requiring oral immunosuppressive medications. Two days after the surgery, the patient presented with pain, photophobia, decreased vision, and a small corneal abrasion. On postoperative day 5, the patient returned with left upper lid vesicular lesions and 2 corneal dendrites. Corrected vision was 20/100 OS, with intraocular pressure of 18 mm Hg and 1+ pigmented cells in the anterior chamber. Cultures of the lid lesions revealed herpes simplex virus (HSV) type 1. The patient was placed on oral acyclovir 800 mg 5 times a day. By day 8, the dendrites had resolved, and by day 15, the lid lesions healed over. HSV keratitis is an uncommon complicat... Herpes journals http://www.medworm.com/rss/comments.php?id=2051261 Sat, 20 Dec 2008 07:54:09 +0100 2051261 http://www.medworm.com/index.php?rid=2045061&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19078985%26dopt%3DAbstract Authors: De Benedetto A, Agnihothri R, McGirt LY, Bankova LG, Beck LA Atopic dermatitis (AD) is a common chronic inflammatory skin disease that has increased in prevalence over the last half century. A growing body of evidence suggests that there are a variety of defects in the innate immune system that collectively affect the development and severity of AD. The reduction in antimicrobial peptides, diminished recruitment of innate immune cells (PMNs, pDC, and NK cells) to the skin, epithelial barrier disruption, and TLR2 defects are just some of the credible explanations for AD patients' susceptibility to pathogens such as Staphylococcus aureus, herpes simplex virus, and vaccinia virus. Although the focus for several years has been to identify defects in the innate immune system that m... Herpes journals http://www.medworm.com/rss/comments.php?id=2045061 Thu, 18 Dec 2008 05:58:00 +0100 2045061 http://www.medworm.com/index.php?rid=2015872&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19053877%26dopt%3DAbstract Authors: Ryder NS Twelve drugs related to therapy and/or prevention of infectious diseases were discontinued from development during 2007. All of these agents were aimed at viral infections, primarily hepatitis C virus (six agents) and HIV (five agents). Nearly half were vaccines, including three against HIV, a therapeutic vaccine for hepatitis C, and a vaccine for prevention and treatment of herpes simplex virus type 2. Each of these agents is briefly reviewed and the reasons for failure are discussed. PMID: 19053877 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=2015872 Sun, 07 Dec 2008 06:24:00 +0100 2015872 http://www.medworm.com/index.php?rid=1115626&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18156035%26dopt%3DAbstract Authors: Gupta R, Warren T, Wald A Genital herpes is the main cause of genital ulcers worldwide; the prevalence of herpes simplex virus (HSV) type 2 infections in the general population ranges from 10% to 60%. Most genital herpes is caused by HSV-2, although HSV-1 accounts for about half of new cases in developed countries. The risk of HIV acquisition is three times higher in people with HSV-2. Neonatal herpes is an uncommon but serious complication of genital herpes. Most genital HSV-2 infections are unrecognised and undiagnosed; infected individuals, even with mild symptoms, shed HSV, and can infect sexual partners. Since clinical diagnosis is neither sensitive nor specific, virological and type-specific serological tests should be used routinely. Oral antiviral drugs for HSV infecti... Herpes journals http://www.medworm.com/rss/comments.php?id=1115626 Wed, 26 Dec 2007 01:07:29 +0100 1115626 http://www.medworm.com/index.php?rid=1115625&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18156037%26dopt%3DAbstract Authors: O'Farrell N, Moodley P, Sturm AW PMID: 18156037 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=1115625 Wed, 26 Dec 2007 01:07:27 +0100 1115625 http://www.medworm.com/index.php?rid=1113046&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18097221%26dopt%3DAbstract Authors: Cowan FM, Humphrey JH, Ntozini R, Mutasa K, Morrow R, Iliff P BACKGROUND:: Genital ulcer disease including that caused by Herpes simplex virus type 2 (HSV-2) and syphilis facilitates sexual transmission of HIV-1. The effect of these infections on intra-partum mother-to-child-transmission (MTCT) of HIV-1 is unknown. METHODS:: A case-control study was conducted using archived sera from HIV-1 positive women enrolled in ZVITAMBO, an MTCT trial. Cases were 509 women who transmitted HIV-1 to their infants intra-partum; controls were 1018 women whose infants remained uninfected at 12 months. Maternal serum collected at delivery, were tested for HSV-2 antibody. The 6-week post-partum sample was also tested for syphilis by RPR and TPHA to identify women with incubating or active syphil... Herpes journals http://www.medworm.com/rss/comments.php?id=1113046 Sun, 23 Dec 2007 01:04:59 +0100 1113046 http://www.medworm.com/index.php?rid=1113045&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18097231%26dopt%3DAbstract CONCLUSIONS:: Among NYC adults, HIV prevalence was consistent with surveillance findings overall. The proportion of unreported HIV was less than estimated nationally, but findings were limited by sample size. Most adults with risky behaviors perceived themselves to be at minimal risk, highlighting the need for risk reduction and routine HIV screening. PMID: 18097231 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=1113045 Sun, 23 Dec 2007 01:04:56 +0100 1113045 http://www.medworm.com/index.php?rid=1008787&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17981684%26dopt%3DAbstract Authors: Fujii G, Ernst W, Adler-Moore J The VesiVaxâ system is based upon the concept that highly potent vaccines can be designed by engineering proteins that are capable of stably inserting themselves into liposomes. Such a nanoscale liposomal particle can then serve as an immunogen for vaccine development. The VesiVaxO vaccine technology platform is designed to make it relatively easy to engineer and produce new vaccines quickly. Vaccines based on the VesiVaxâ system have been designed against the influenza virus and herpes simplex type 2 virus, the causative agents of the "flu" and genital herpes, respectively. Both vaccines have been tested in animal models and have demonstrated significant protective efficacy from challenge with lethal doses of virus. Assays of the immu... Herpes journals http://www.medworm.com/rss/comments.php?id=1008787 Wed, 07 Nov 2007 01:05:31 +0100 1008787 http://www.medworm.com/index.php?rid=1008786&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17981691%26dopt%3DAbstract Authors: Todo T Genetically engineered, conditionally replicating herpes simplex viruses type 1 (HSV-1) are promising therapeutic agents for cancer. They can replicate in situ, spread, and exhibit oncolytic activity via a direct cytocidal effect. In addition, oncolytic HSV-1 can transfer and express foreign genes in host cells. The phase I clinical study with G207, a double-mutated HSV-1, in recurrent malignant glioma patients has shown that oncolytic HSV-1 can be safely administered into human brains. The therapeutic benefits of oncolytic HSV-1 depend on the extent of both intratumoral viral replication and induction of host antitumor immune responses. We develop new-generation oncolytic HSV-1 by enhancing these properties while retaining the safety features. G47? was created from G20... Herpes journals http://www.medworm.com/rss/comments.php?id=1008786 Wed, 07 Nov 2007 01:05:29 +0100 1008786 http://www.medworm.com/index.php?rid=1008785&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17981767%26dopt%3DAbstract Authors: Toth Z, Stamminger T One of the characteristic features of herpesviruses is that most of their genes are intronless. Thus, their replication relies on the selective nuclear export of intronless viral mRNAs, which have to compete with the nuclear export of bulk spliced cellular mRNAs. Therefore, the regulation of nuclear mRNA export is crucial for the replication and pathogenesis of herpesviruses. Besides the thymidine kinase transcript of herpes simplex virus type 1, which contains specific sequences to facilitate the nuclear export of intronless mRNA, other cis-acting RNA elements for nuclear mRNA export have not yet been identified in the rest of herpesviral intronless mRNAs. Instead, emerging studies show that herpesviruses encode viral mRNA export factors, which interact w... Herpes journals http://www.medworm.com/rss/comments.php?id=1008785 Wed, 07 Nov 2007 01:05:27 +0100 1008785 http://www.medworm.com/index.php?rid=1002078&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17976133%26dopt%3DAbstract Authors: Frangoul H, Wills M, Crossno C, Engel M, Domm J HSV causes serious complications in immunocompromised patients, especially SCT recipients. Although ACV is an effective antiviral prophylaxis, the emergence of ACV resistance is a growing problem. The authors describe two cases of fatal ACV-resistant HSV in two pediatric patients following unrelated donor SCT. Despite the in vitro sensitivity of the HSV isolates to foscarnet, both patients failed to respond to foscarnet therapy. Other antiviral therapies should be considered in those patients who fail to show rapid clinical improvement. PMID: 17976133 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=1002078 Sun, 04 Nov 2007 00:12:51 +0100 1002078 http://www.medworm.com/index.php?rid=927411&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17910656%26dopt%3DAbstract Authors: Ibáñez JP, Monteverde ML, Diaz MA, Goldberg J, Turconi AF CAN is a common cause of late graft loss. Nephrotoxicity due to CNIs is known to contribute to CAN. We retrospectively evaluated the efficacy and safety of SRL in pediatric renal Tx recipients showing CAN in their allograft biopsy. Twenty-one patients aged 10.4 +/- 4.6 yr at Tx time receiving CNIs as primary immunosuppression were converted to SRL at 58.9 +/- 49.1 months after Tx, due to progressive decline of renal function and biopsy proven CAN. Mean follow-up after switch was 19.7 +/- 9.5 months. All patients received CsA as part of the immunosuppressive regimen, at a mean dose 4.4 +/- 1.2 mg/kg/day. Mean daily dose of SRL three month after conversion was 2.6 +/- 0.8 mg/body surface area/day and the mean th... Herpes journals http://www.medworm.com/rss/comments.php?id=927411 Fri, 05 Oct 2007 00:00:37 +0100 927411 http://www.medworm.com/index.php?rid=927410&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17912340%26dopt%3DAbstract Authors: Chen L, Jha P, Stirling B, Sgaier SK, Daid T, Kaul R, Nagelkerke N, BACKGROUND: It is commonly assumed that sexual risk factors for heterosexual HIV transmission in sub-Saharan Africa, such as multi-partner sex, paid sex and co-infections, become less important as HIV epidemics mature and prevalence increases. METHODS AND FINDINGS: We conducted a systematic review of 68 African epidemiological studies from 1986 to 2006 involving 17,000 HIV positive adults and 73,000 controls. We used random-effects methods and stratified results by gender, time, background HIV prevalence rates and other variables. The number of sex partners, history of paid sex, and infection with herpes simplex virus (HSV-2) or other sexually-transmitted infections (STIs) each showed significant associations... Herpes journals http://www.medworm.com/rss/comments.php?id=927410 Fri, 05 Oct 2007 00:00:32 +0100 927410 http://www.medworm.com/index.php?rid=927409&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17912551%26dopt%3DAbstract Authors: Bayram N, Ciftdogan DY, Karapinar B, Ozgiray E, Polat M, Cagliyan E, Vardar F A 15-year-old girl was referred to our hospital due to fever, headache, and vomiting of 7 days duration and focal motor convulsion at the day of referral. Her clinical signs and cerebral imaging findings were found to be compatible with herpes simplex encephalitis. In spite of prompt acyclovir administration, her consciousness deteriorated gradually. Emergent cranial magnetic resonance imaging demonstrated a shift of midline intracranial structures. Decompressive surgery resulted in partial improvement in the shift of midline intracranial structures and potentially saved the patient's life. This case report stresses the importance of proper management of increased intracranial pressure in patients wi... Herpes journals http://www.medworm.com/rss/comments.php?id=927409 Wed, 03 Oct 2007 04:00:00 +0100 927409 http://www.medworm.com/index.php?rid=924695&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17909885%26dopt%3DAbstract This study aimed to evaluate the use of the Roche LightCycler as a platform for performing the NASBA assay for detection of EV. A diverse subgenera of EV were used to assess the specificity of the NASBA assay, including coxsackie, echovirus, poliovirus, and other enteroviruses together with related and unrelated viruses, including rhinovirus, respiratory syncytial virus, herpes simplex virus, adenovirus, influenza virus A, and cytomegalovirus. All species of EV tested were successfully detected using NASBA and no cross reactivity with other viruses was observed. Using serial dilutions of EV to assess sensitivity, the NASBA assay was compared to an in-house EV RT-PCR assay. The NASBA assay demonstrated a higher level of sensitivity. Fifty-one clinical samples positive for EV by viral cultur... Herpes journals http://www.medworm.com/rss/comments.php?id=924695 Tue, 02 Oct 2007 04:00:00 +0100 924695 http://www.medworm.com/index.php?rid=915992&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17404685%26dopt%3DAbstract We present evidence that single mutations close to a predicted functional domain of an essential HSV-1 replication enzyme (helicase) are associated with drug resistance and virus growth characteristics. PMID: 17404685 [PubMed - indexed for MEDLINE] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=915992 Mon, 01 Oct 2007 12:05:57 +0100 915992 http://www.medworm.com/index.php?rid=836314&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17763323%26dopt%3DAbstract Authors: Sengupta N, Taha Y, Scott FT, Leedham-Green ME, Quinlivan M, Breuer J A total of 298 patients with herpes zoster were recruited as part of 2 community-based studies in East London between 1998 and 2003. Single nucleotide-polymorphism analysis of 4 regions (genes 1, 21, 37, and 60) found that most genotypes were European strains C and B, representing 58% and 21% of all samples collected. No change in the proportion of these European clades has occurred during the past 80 years, strongly supporting the hypothesis that these strains are indigenous to the United Kingdom. White patients almost exclusively had reactivation of genotypes C (66%) and B (21%), whereas patients from Africa, Asia, or the Caribbean mainly had reactivation of genotypes A and J. An increase in BglI-positive ... Herpes journals http://www.medworm.com/rss/comments.php?id=836314 Sun, 02 Sep 2007 00:07:27 +0100 836314 http://www.medworm.com/index.php?rid=807944&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17703414%26dopt%3DAbstract Conclusion. The data support the hypothesis of early acquisition and horizontal transmission, via saliva, of HHV-8 subtype E in Amerindian populations. PMID: 17703414 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=807944 Mon, 20 Aug 2007 00:30:37 +0100 807944 http://www.medworm.com/index.php?rid=807943&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17703415%26dopt%3DAbstract Conclusion. These data clearly demonstrate the importance of TNF- alpha and IL-1 beta in protection against HSV-1 encephalitis in this mouse model. PMID: 17703415 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=807943 Mon, 20 Aug 2007 00:30:35 +0100 807943 http://www.medworm.com/index.php?rid=541138&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17429545%26dopt%3DAbstract CONCLUSION: ALA-PDT could be effective in treating HSV infections, which may provide a new approach to the treatment of viral infections. Key words: Photochemotherapy; Aminolevulinic Acid; Herpes simplex virus; Guinea Pigs. PMID: 17429545 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=541138 Fri, 13 Apr 2007 19:39:09 +0100 541138 http://www.medworm.com/index.php?rid=508691&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17390046%26dopt%3DAbstract Authors: Li J, Shen F, Wu D, Wei LX, Wang YZ, Shi LH, Zou Y, Wu MC The molecular mechanisms of apoptosis caused by IFN-gamma (interferon gamma)/LIGHT (lymphotoxin-related inducible ligand that competes for glycoprotein D binding to herpes virus entry mediator on T cells) have not been studied in detail. The present study was undertaken to gain insights into the signaling pathways involved in apoptosis induced by IFN-gamma/LIGHT in hepatocellular carcinoma (HCC) cell lines. Cell proliferation assay, flow cytometry, Western blotting, gene transfer and RNA interference were used in this study. LIGHT enhanced IFN-gamma-mediated apoptosis in Hep3B cells. IFN-gamma/LIGHT-induced apoptosis was inhibited by blocking peptides to the lymphotoxin beta receptor (LT-beta R), and not by the herpes v... Herpes journals http://www.medworm.com/rss/comments.php?id=508691 Thu, 29 Mar 2007 16:22:04 +0100 508691 http://www.medworm.com/index.php?rid=508686&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17390091%26dopt%3DAbstract In conclusion, we described novel and robust methods to detect intercellular trafficking. From our data we concluded that protein transmission of TK by VP22 for gene therapy is not likely to be successful. In addition, we described a useful and quantifiable assay to measure the enzymatic activity of TK and TK fusion proteins, and described some common properties of VP22 fusion proteins that may explain the different results that have been obtained by others. PMID: 17390091 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=508686 Thu, 29 Mar 2007 16:22:04 +0100 508686 http://www.medworm.com/index.php?rid=475651&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17357052%26dopt%3DAbstract Authors: Chisholm SE, Howard K, Gomez MV, Reyburn HT Natural killer (NK) cells are an important component of the immune response to a number of viruses; however, the molecular basis of how NK cells discriminate between healthy and virus-infected cells is largely unknown. Here, we show that expression of the immediate-early gene product ICP0 is sufficient to produce an increased susceptibility to NK lysis of herpes simplex virus (HSV)-infected cells. This effect does not depend on down-regulation of major histocompatibility complex class I molecules or on the induction of expression of ligands for the activating NKG2D receptor. Detection by NK cells of the changes in the target cell induced by HSV ICP0 gene expression depends on the natural cytotoxicity receptors (NCRs) NKp30, NKp44, an... Herpes journals http://www.medworm.com/rss/comments.php?id=475651 Fri, 16 Mar 2007 20:12:02 +0100 475651 http://www.medworm.com/index.php?rid=457744&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17342663%26dopt%3DAbstract Authors: Marrazzo JM, Martin DH In the past several years, the collective understanding of cervicitis has extended beyond the recognition of Chlamydia trachomatis and Neisseria gonorrhoeae as the prime etiologic suspects. Trichomonas vaginalis and herpes simplex virus cause cervicitis, and both Mycoplasma genitalium and bacterial vaginosis have emerged as new candidate etiologic agents or conditions. However, major gaps in our knowledge of this common condition remain. Putative etiologic agents have not been identified in many women with cervicitis. Moreover, cervicitis occurs in a relatively small proportion of women with chlamydia or gonorrhea. Finally, scant research has addressed the clinical response of nonchlamydial and nongonococcal cervicitis to antibiotic therapy, and there ar... Herpes journals http://www.medworm.com/rss/comments.php?id=457744 Thu, 08 Mar 2007 18:38:02 +0100 457744 http://www.medworm.com/index.php?rid=455408&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17340036%26dopt%3DAbstract Authors: Rodrigues Cdos S, Filipe P, Solana Mdel M, de Almeida LS, de Castro JC, Gomes MM PMID: 17340036 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=455408 Wed, 07 Mar 2007 21:30:02 +0100 455408 http://www.medworm.com/index.php?rid=455409&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17339131%26dopt%3DAbstract CONCLUSIONS: This study suggests that in patients with acute HZ the severity of the disease and depression at presentation are the main correlates of pain intensity. PMID: 17339131 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=455409 Sat, 03 Mar 2007 05:00:00 +0100 455409 http://www.medworm.com/index.php?rid=452832&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17337405%26dopt%3DAbstract Authors: Satzger I, Kapp A, Gutzmer R PMID: 17337405 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=452832 Fri, 02 Mar 2007 05:00:00 +0100 452832 http://www.medworm.com/index.php?rid=447383&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17329186%26dopt%3DAbstract Authors: Crawford DH PMID: 17329186 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=447383 Thu, 01 Mar 2007 05:00:00 +0100 447383 http://www.medworm.com/index.php?rid=447381&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17332203%26dopt%3DAbstract CONCLUSION: Compared with a single recommended course of antenatal steroids, multiple courses of antenatal betamethasone are not associated with a deleterious effect on auditory neural maturation in 28 to 32 weeks' gestational age infants. PMID: 17332203 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=447381 Thu, 01 Mar 2007 05:00:00 +0100 447381 http://www.medworm.com/index.php?rid=447382&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17329344%26dopt%3DAbstract Authors: Bihl F, Narayan M, Chisholm JV, Henry LM, Suscovich TJ, Brown EE, Welzel TM, Kaufmann DE, Zaman TM, Dollard S, Martin JN, Wang F, Scadden DT, Kaye KM, Brander C The cellular immunity against Kaposi's Sarcoma-associated herpes virus (KSHV) is poorly characterized and has not been compared to T cell responses against other human herpesviruses. Here, novel and dominant targets of the KSHV-specific cellular immunity are identified and compared to T cells specific for lytic and latent antigens in a second human gamma-herpesvirus, EBV. The data identify a novel HLA-B57- and -B58-restricted epitope in the ORF57 protein and show consistently close parallels in immune phenotypes and functional response patterns between cells targeting lytic or latent KSHV- and EBV -encoded antigens, su... Herpes journals http://www.medworm.com/rss/comments.php?id=447382 Wed, 28 Feb 2007 05:00:00 +0100 447382 http://www.medworm.com/index.php?rid=444734&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17327376%26dopt%3DAbstract Conclusions: NV1023 causes significant cytotoxicity of anaplastic, medullary, and papillary thyroid cancers. Nectin-1 is a novel marker of thyroid cancer sensitivity to herpes oncolytic therapy that might guide patient selection for therapy. PMID: 17327376 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=444734 Tue, 27 Feb 2007 05:00:00 +0100 444734 http://www.medworm.com/index.php?rid=444732&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17327416%26dopt%3DAbstract Authors: Ciceri F, Bonini C, Marktel S, Zappone E, Servida P, Bernardi M, Pescarollo A, Bondanza A, Peccatori J, Rossini S, Magnani Z, Salomoni M, Benati C, Ponzoni M, Callegaro L, Corradini P, Bregni M, Traversari C, Bordignon C The extensive exploitation of the anti-tumor effect of donor lymphocytes infused after allogeneic hematopoietic cell transplantation (allo-HSCT) is limited by the risk of graft-versus-host disease (GvHD). To overcome this limitation, we investigated the therapeutic potential of donor lymphocytes engineered with the suicide gene thymidine kinase of Herpes Simplex virus (TK) in 23 patients experiencing recurrence of hematologic malignancies after allo-HSCT. Long-term follow-up of infused patients included analysis of engraftment of genetically engineered lymphoc... Herpes journals http://www.medworm.com/rss/comments.php?id=444732 Tue, 27 Feb 2007 05:00:00 +0100 444732 http://www.medworm.com/index.php?rid=444730&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17327829%26dopt%3DAbstract This study confirmed the safety profile and possibility of clinical response at the surrogate marker level in a clinical trial of HSV-tk gene therapy for hormone-refractory prostate cancer.Molecular Therapy advance online publication 27 February 2007 doi:10.1038/sj.mt.6300096. PMID: 17327829 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=444730 Tue, 27 Feb 2007 05:00:00 +0100 444730 http://www.medworm.com/index.php?rid=416102&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17299270%26dopt%3DAbstract Authors: Oxman MN PMID: 17299270 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=416102 Thu, 15 Feb 2007 15:50:03 +0100 416102 http://www.medworm.com/index.php?rid=416101&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17299711%26dopt%3DAbstract Conclusions. Administration of GCs at a critical time during viral infection is associated with neuroprotection and survival in experimental HSV-1 encephalitis. PMID: 17299711 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=416101 Thu, 15 Feb 2007 15:50:03 +0100 416101 http://www.medworm.com/index.php?rid=412755&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17291217%26dopt%3DAbstract Authors: Bonatti H, Aigner F, De Clercq E, Boesmueller C, Widschwendner A, Larcher C, Margreiter R, Schneeberger S Human papilloma virus (HPV)-associated diseases are increasingly diagnosed in solid organ recipients. Cidofovir (CDV) is a broad-spectrum antiviral agent with activity against all human herpes viruses and HPV. From 2000-2004, a total of 1303 solid organ transplants (SOT) were performed at our center. Six transplant recipients were treated with topical CDV for HPV-associated lesions. One cardiac recipient responded to a single injection of CDV into his recurrent anal condylomata. In a renal recipient with recurrent penile condylomata CDV was injected into the lesions four times (2 week interval) until lesions regressed. One renal recipient developed multiple vaginal and ana... Herpes journals http://www.medworm.com/rss/comments.php?id=412755 Tue, 13 Feb 2007 21:30:02 +0100 412755 http://www.medworm.com/index.php?rid=412754&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17294333%26dopt%3DAbstract CONCLUSION: Radioisotope therapy of HSV1-tk-expressing tumor cells with (131)I-FIAU is reported for the first time. Lack of synergy between (131)I-FIAU and GCV does not warrant further investigation of combination treatment with the two agents. PMID: 17294333 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=412754 Sat, 10 Feb 2007 07:00:00 +0100 412754 http://www.medworm.com/index.php?rid=407972&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17290283%26dopt%3DAbstract Authors: Fu X, Tao L, Zhang X Oncolytic viruses derived from herpes simplex virus (HSV) have shown considerable promise as antitumor agents against solid tumors including ovarian cancer. The current group of oncolytic HSVs was constructed exclusively from type 1 HSV. To exploit further the therapeutic potential of replication-selective viruses, we constructed an oncolytic virus from type 2 HSV by deleting the protein kinase domain of the viral ICP10 gene, which targets the activated Ras signaling pathway in tumor cells. In the study reported here, we administered this HSV-2-derived virus intraperitoneally (i.p.) to nude mice bearing metastatic human ovarian tumor xenografts, evaluated its oncolytic activity, and compared with to that of a virus constructed from HSV-1. Two injections of... Herpes journals http://www.medworm.com/rss/comments.php?id=407972 Fri, 09 Feb 2007 07:00:00 +0100 407972 http://www.medworm.com/index.php?rid=404367&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17284082%26dopt%3DAbstract Authors: Lingappa JR, Celum C A synergy between HIV type-1 (HIV-1) and herpes simplex virus-2 (HSV-2) has been demonstrated in many epidemiological and clinical studies over the last decade. HIV-1 infection exacerbates the clinical impact and frequency of HSV-2 reactivation events; furthermore, HSV-2 infection exacerbates the risk of HIV acquisition and transmission and may accentuate HIV disease progression. In order to maximise the impact of existing and future therapeutic and preventive interventions, this article reviews the epidemiological, clinical and therapeutic considerations associated with episodic treatment and suppression of HSV-2 infection in HIV-infected individuals.Specifically, this article describes the current expanding epidemics of both HIV and HSV-2, and how high r... Herpes journals http://www.medworm.com/rss/comments.php?id=404367 Thu, 08 Feb 2007 17:40:03 +0100 404367 http://www.medworm.com/index.php?rid=402639&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17164556%26dopt%3DAbstract CONCLUSIONS: The size of the R2 repeat region can also be different in single Oka vaccine strains. In German VZV wild-type strains, the R2 fragment seems to be not as variable as in Japanese wild-type strains. PMID: 17164556 [PubMed - indexed for MEDLINE] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=402639 Wed, 07 Feb 2007 20:30:03 +0100 402639 http://www.medworm.com/index.php?rid=391145&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17264496%26dopt%3DAbstract Authors: Lepisto AJ, Frank GM, Hendricks RL Properties of the cornea such as a lack of blood and lymphatic vessels, a lack of professional antigen-presenting cells, and exposure to immunosuppressive factors in the aqueous humor contribute to a relative state of immune privilege. Ironically, corneal damage and the accompanying visual morbidity following herpes simplex virus type 1 (HSV-1) infection does not results from uncontrolled viral replication, but from an immunoinflammatory process referred to as herpes stromal keratitis (HSK). This review highlights changes in the immune-privileged status of the cornea following HSV-1 infection that contribute to HSK. PMID: 17264496 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=391145 Fri, 02 Feb 2007 00:32:02 +0100 391145 http://www.medworm.com/index.php?rid=391144&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17264500%26dopt%3DAbstract This article will review the history of ARN, the typical clinical findings, and methods of diagnosis. Information from studies of the mouse model of ARN including development of anterior chamber-associated immune deviation (ACAID) and routes of spread will be reconsidered, and the combined information from human and mouse studies will be discussed to suggest mechanisms that contribute to the pathogenesis of ARN in human patients. Finally, puzzles and questions about the disease will be considered. PMID: 17264500 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=391144 Fri, 02 Feb 2007 00:32:02 +0100 391144 http://www.medworm.com/index.php?rid=381755&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17249857%26dopt%3DAbstract CONCLUSIONS: The management of acute/subacute herpes zoster was found to result in substantial healthcare costs, with outpatient care and prescription drugs comprising the majority of the cost burden. To more fully understand the overall cost of herpes zoster disease to society, future studies should examine the healthcare costs associated with post-herpetic neuralgia and productivity losses due to herpes zoster and post-herpetic neuralgia. PMID: 17249857 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=381755 Fri, 26 Jan 2007 19:40:02 +0100 381755 http://www.medworm.com/index.php?rid=381754&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17250503%26dopt%3DAbstract Conclusions: In the present study, herpesviruses were determined at a high rate in middle ear fluids of children with OME. However, the present study is a preliminary study and more extensive studies, especially experimental studies, are required to elucidate the role of herpesviruses in pathogenesis of OME and whether there is a relation between rate of herpesviruses in OME cases, and the reactivation of latent infections. PMID: 17250503 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=381754 Fri, 26 Jan 2007 19:40:02 +0100 381754 http://www.medworm.com/index.php?rid=381752&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17251553%26dopt%3DAbstract Authors: Strang BL, Stow ND Circularization of the herpes simplex virus type 1 (HSV-1) genome is thought to be an important early event during the lytic cycle. Previous studies from another laboratory using a cell line, tsBN2, that carries a temperature-sensitive mutation in the gene encoding the regulator of chromatin condensation 1 (RCC1) indicated that functional RCC1 was required for HSV-1 genome circularization and subsequent viral DNA synthesis. Here, HSV-1 infection of tsBN2 cells has been re-examined by utilizing both wild-type HSV-1 and a derivative that enables a direct demonstration of circularization. At the non-permissive temperature, when RCC1 was absent, both circularization and viral DNA synthesis were reduced, but not abolished. However, no infectious progeny virus was... Herpes journals http://www.medworm.com/rss/comments.php?id=381752 Fri, 26 Jan 2007 19:40:02 +0100 381752 http://www.medworm.com/index.php?rid=381751&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17251554%26dopt%3DAbstract Authors: Chabaud S, Sasseville AM, Elahi SM, Caron A, Dufour F, Massie B, Langelier Y The R1 subunit (ICP10) of herpes simplex virus type 2 (HSV-2) ribonucleotide reductase (RR), which in addition to its C-terminal reductase domain possesses a unique N-terminal domain of about 400 aa, protects cells against apoptosis. As the NH(2) domain on its own is not antiapoptotic, it has been postulated that both domains of R1 or part(s) of them could be necessary for this function. Here, N- and C-terminal deletions were introduced in HSV-2 R1 to map the domain(s) involved in its antiapoptotic potential. The results showed that, whereas most of the NH(2) domain including part of the recently described putative alpha-crystallin domain is dispensable for antiapoptotic activity, it is the integrity ... Herpes journals http://www.medworm.com/rss/comments.php?id=381751 Fri, 26 Jan 2007 19:40:02 +0100 381751 http://www.medworm.com/index.php?rid=381750&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17251811%26dopt%3DAbstract CONCLUSIONS:: Real-time PCR quantitated HSV genome in the cornea even at a quiescent phase of infection. HSV genome was detected in the corneas and scleras without a past history of herpetic keratitis by this method. PMID: 17251811 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=381750 Fri, 26 Jan 2007 19:40:02 +0100 381750 http://www.medworm.com/index.php?rid=381753&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17251241%26dopt%3DAbstract Authors: Noppeney U, Patterson K, Tyler LK, Moss H, Stamatakis EA, Bright P, Mummery C, Price CJ Both herpes simplex virus encephalitis (HSVE) and semantic dementia (SD) typically affect anterior temporal lobe structures. Using voxel-based morphometry (VBM), this study compared the structural damage in four HSVE patients having a semantic deficit particularly affecting knowledge of living things and six SD patients with semantic impairment across all categories tested. Each patient was assessed relative to a group of control subjects. In both patient groups, left anterior temporal damage extended into the amygdala. In patients with HSVE, extensive grey matter loss was observed predominantly in the medial parts of the anterior temporal cortices bilaterally in SD patients the abnormaliti... Herpes journals http://www.medworm.com/rss/comments.php?id=381753 Wed, 24 Jan 2007 07:00:00 +0100 381753 http://www.medworm.com/index.php?rid=380195&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17245713%26dopt%3DAbstract Authors: Shirokov D, Kadyrova E, Anokhina M, Kondratyeva T, Gourtsevich V, Tupitsyn N Primary effusion lymphoma is a rare tumor of B-cell derivation which is associated with human herpes virus type 8 (HHV-8) in 100% and with human immunodeficiency virus (HIV) in most of cases. The paper describes the first case in Russia of HIV(-) HHV-8(+) Epstein-Barr virus (EBV)(+) primary effusion lymphoma in a male patient aged 56 years. The tumor was located in the pleural cavity. Interestingly, the patient was HIV-negative while having a positive tumor HHV-8 test. There are only 22 similar cases described worldwide. J. Med. Virol. 79:270-277, 2007. (c) 2007 Wiley-Liss, Inc. PMID: 17245713 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=380195 Tue, 23 Jan 2007 07:00:00 +0100 380195 http://www.medworm.com/index.php?rid=361357&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17116099%26dopt%3DAbstract Authors: da Silva HM, Boullosa JL, Arruda MA PMID: 17116099 [PubMed - indexed for MEDLINE] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=361357 Sat, 20 Jan 2007 14:54:02 +0100 361357 http://www.medworm.com/index.php?rid=361356&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17233544%26dopt%3DAbstract Authors: Christo PJ, Hobelmann G, Maine DN Many individuals across the globe have been exposed to the varicella-zoster virus (VZV) that causes chickenpox. After chickenpox has resolved, the virus remains latent in the dorsal root ganglia where it can re-emerge later in life as herpes zoster, otherwise known as shingles. Herpes zoster is a transient disease characterised by a dermatomal rash that is usually associated with significant pain. Post-herpetic neuralgia (PHN) is the term used for the condition that exists if the pain persists after the rash has resolved. Advanced age and compromised cell-mediated immunity are significant risk factors for reactivation of herpes zoster and the subsequent development of PHN. Though the pathophysiology of PHN is unclear, studies suggest periphera... Herpes journals http://www.medworm.com/rss/comments.php?id=361356 Sat, 20 Jan 2007 14:54:02 +0100 361356 http://www.medworm.com/index.php?rid=361355&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17234480%26dopt%3DAbstract We present a case of HSV pneumonia in a heart transplant recipient and include a review of the clinical presentation, diagnostic findings, and therapy of HSV pneumonia. PMID: 17234480 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=361355 Sat, 20 Jan 2007 14:54:02 +0100 361355 http://www.medworm.com/index.php?rid=361354&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17234598%26dopt%3DAbstract Authors: Deschênes-Furry J, Mousavi K, Bolognani F, Neve RL, Parks RJ, Perrone-Bizzozero NI, Jasmin BJ After axotomy, expression of acetylcholinesterase (AChE) is greatly reduced in the superior cervical ganglion (SCG); however, the molecular events involved in this response remain unknown. Here, we first examined AChE mRNA levels in the brain of transgenic mice that overexpress human HuD. Both in situ hybridization and reverse transcription-PCR demonstrated that AChE transcript levels were increased by more than twofold in the hippocampus of HuD transgenic mice. Additionally, direct interaction between the HuD transgene product and AChE mRNA was observed. Next, we examined the role of HuD in regulating AChE expression in intact and axotomized rat SCG neurons. After axotomy of the adu... Herpes journals http://www.medworm.com/rss/comments.php?id=361354 Sat, 20 Jan 2007 14:54:02 +0100 361354 http://www.medworm.com/index.php?rid=361353&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17234749%26dopt%3DAbstract Authors: Aghi M, Rabkin SD, Martuza RL Wild-type (WT) herpes simplex virus (HSV) causes some pathology, such as ocular keratitis, by increasing infected tissue vascularity, possibly reflecting altered angiogenic factor expression in infected cells. Oncolytic HSVs possess specific mutations enabling selective replication in tumor cells. We investigated whether this ability to enhance infected tissue vascularity is retained in oncolytic HSV, which could be an undesirable effect of oncolytic HSVs that may need to be addressed when treating tumors with oncolytic HSVs. s.c. tumors derived from U87 human glioma cells in athymic mice were treated with oncolytic HSVs G207 or G47Delta in the presence or absence of a recombinant protein composed of the three type-1 repeats (3TSR) of thrombospond... Herpes journals http://www.medworm.com/rss/comments.php?id=361353 Sat, 20 Jan 2007 14:54:02 +0100 361353 http://www.medworm.com/index.php?rid=361352&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17235301%26dopt%3DAbstract Authors: Gomez-Sebastian S, Gimenez-Cassina A, Diaz-Nido J, Lim F, Wade-Martins R Friedreich's ataxia (FA) is the most common recessive ataxia, affecting 1-2 in 50,000 Caucasians, and there is currently no effective cure or treatment. FA results from a deficiency of the mitochondrial protein frataxin brought about by a repeat expansion in intron 1 of the FRDA gene. The main areas affected are the central nervous system (particularly the spinocerebellar system) and cardiac tissue. Therapies aimed at alleviating the neurological degeneration have proved unsuccessful to date. Here, we describe the construction and delivery of high capacity herpes simplex virus type 1 (HSV-1) amplicon vectors expressing the entire 80 kb FRDA genomic locus, driven by the endogenous FRDA promoter and includi... Herpes journals http://www.medworm.com/rss/comments.php?id=361352 Sat, 20 Jan 2007 14:54:02 +0100 361352 http://www.medworm.com/index.php?rid=361351&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17235305%26dopt%3DAbstract Authors: Mahller YY, Vaikunth SS, Currier MA, Miller SJ, Ripberger MC, Hsu YH, Mehrian-Shai R, Collins MH, Crombleholme TM, Ratner N, Cripe TP Malignant peripheral nerve sheath tumors (MPNSTs), driven in part by hyperactive Ras and epidermal growth factor receptor (EGFR) signaling, are often incurable. Testing of therapeutics for MPNST has been hampered by lack of adequate xenograft models. We previously documented that human MPNST cells are permissive for lytic infection by oncolytic herpes simplex viruses (oHSV). Herein we developed and characterized a xenograft model of human MPNST and evaluated the antitumor effects of oHSV mutants (G207 and hrR3) and the EGFR inhibitor, erlotinib. Additive cytotoxicity of these agents was found in human MPNST cell lines, suggesting that EGFR signa... Herpes journals http://www.medworm.com/rss/comments.php?id=361351 Sat, 20 Jan 2007 14:54:02 +0100 361351 http://www.medworm.com/index.php?rid=361350&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17235309%26dopt%3DAbstract Authors: Lemken ML, Wolf C, Wybranietz WA, Schmidt U, Smirnow I, Bühring HJ, Mack AF, Lauer UM, Bitzer M The intercellular trafficking property of the herpes simplex virus type 1 tegument protein VP22 makes it a promising tool for overcoming low transduction efficiencies in gene therapy. However, recent reports suggest not only that VP22 cannot facilitate intercellular spreading and that trafficking of VP22 fusion proteins results from artifacts of cell fixation only. To provide direct evidence for the presence or absence of VP22-mediated intercellular trafficking, we generated an adenoviral vector with a dual expression cassette for VP22 fused to green fluorescent protein (VP22 GFP) and DsRed under the control of distinct human cytomegalovirus immediate-early enhancer/promoter region... Herpes journals http://www.medworm.com/rss/comments.php?id=361350 Sat, 20 Jan 2007 14:54:02 +0100 361350 http://www.medworm.com/index.php?rid=361349&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17235314%26dopt%3DAbstract We report the application of lentiviral vectors for transduction of T cells in cytokine culture, without activation through the T-cell receptor. Using vectors encoding either enhanced green fluorescent protein or a truncated CD34/mutant HSVTK fusion selection/suicide construct, we investigated the properties of T cells after gene modification. We found that following cytokine stimulation, a fraction of T cells undergoes division, and transgene expression occurred predominantly in these cells. Antiviral and alloreactive responses were preserved in these populations, and in contrast to fully activated T cells, there was minimal perturbation of regulatory T-cell numbers. We conclude that the use of interleukin-7 for lentiviral transduction offers the greatest potential for gene transfer to T ... Herpes journals http://www.medworm.com/rss/comments.php?id=361349 Sat, 20 Jan 2007 14:54:02 +0100 361349 http://www.medworm.com/index.php?rid=360656&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17228514%26dopt%3DAbstract Authors: Várkonyi V Sexually transmitted infections in the XXI century. The most important measurements in the management of sexually transmitted diseases are discussed. Course and incidence of classical venereal diseases, especially that of syphilis are detailed. In 2004 the incidence of early infectious syphilis significantly increased and it is emphasized that this tendency can be observed also in 2005. Differential diagnostic issues of male and female urogenital diseases with discharge are reviewed, and problems of STDs of viral origin (genital herpes, genital warts, HIV infection) are briefly discussed. The importance of careful and specific microbiological diagnostics in the management of patients with venereal diseases and other sexually transmitted infections is emphasized. ... Herpes journals http://www.medworm.com/rss/comments.php?id=360656 Sat, 20 Jan 2007 04:18:02 +0100 360656 http://www.medworm.com/index.php?rid=360655&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17229687%26dopt%3DAbstract SIALIC ACID ON HERPES SIMPLEX VIRUS TYPE-1 ENVELOPE GLYCOPROTEINS IS REQUIRED FOR EFFICIENT INFECTION OF CELLS. J Virol. 2007 Jan 17; Authors: Teuton JR, Brandt CR Herpes simplex virus type 1 (HSV-1) envelope proteins are post-translationally modified by the addition of sialic acids to the termini of the glycan side chains. Although gC, gD, and gH are sialylated, it is not known if sialic acids on these envelope proteins are functionally important. Digestion of sucrose gradient purified virions for 4 h with neuraminidases that remove both alpha2,3 and alpha2,6 linked sialic acids reduced titers by 1000-fold. Digestion with a alpha2,3-specific neuraminidase had no effect suggesting that alpha2,6 linked sialic acids are required for infection. Lectins specific for either alpha2,3... Herpes journals http://www.medworm.com/rss/comments.php?id=360655 Sat, 20 Jan 2007 04:18:02 +0100 360655 http://www.medworm.com/index.php?rid=360654&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17229694%26dopt%3DAbstract Authors: Sànchez R, Mohr I Among the many host genes induced by virus infection and interferon, the eIF2alpha kinase PKR and the 2'-5'oligoadenylate synthetase (OAS) are both activated by dsRNA produced in virus-infected cells. Furthermore, each is a critical component that independently acts to inhibit virus replication and thereby contributes to the establishment of an antiviral state. As part of their tactics to foil host defense mechanisms, some viruses prevent the induction of interferon responsive genes at the level of transcription. Other viruses, such as HSV-1, can additionally replicate in interferon-treated cells and must also evade the actions of host defense proteins such as PKR and OAS that have been previously synthesized and merely await detection of an activating signa... Herpes journals http://www.medworm.com/rss/comments.php?id=360654 Sat, 20 Jan 2007 04:18:02 +0100 360654 http://www.medworm.com/index.php?rid=360653&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17229696%26dopt%3DAbstract In this study, the effects of each substitution on the production of viral progeny, viral DNA replication, and DNA replication fidelity were examined. Each substitution mutant was able to complement the replication of a UL42 null mutant in transient complementation assays, and to support the replication of a plasmid DNA containing HSV-1 origin sequences in transient DNA replication assays. Mutant viruses containing each substitution and a lacZ insertion in a non-essential region of the genome were constructed and characterized. In single cycle growth assays, the mutants produced significantly less progeny virus than a control virus containing wild type UL42. Real time PCR assays revealed that these UL42 mutants synthesized less viral DNA during the early phase of infection. Interestingly, ... Herpes journals http://www.medworm.com/rss/comments.php?id=360653 Sat, 20 Jan 2007 04:18:02 +0100 360653 http://www.medworm.com/index.php?rid=360652&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17230408%26dopt%3DAbstract Conclusions. The occurrence of HSV-2 is high in this population, but knowledge is low. Development of education programs to increase awareness of HSV-2 is critical. The control of both HSV-2 and HIV infections is a major public health priority in Moshi. Prevention interventions in this and other high prevalence populations might most effectively target younger women, before initiation of sexual activity. PMID: 17230408 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=360652 Sat, 20 Jan 2007 04:18:02 +0100 360652 http://www.medworm.com/index.php?rid=360651&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17230409%26dopt%3DAbstract Authors: Loparev VN, Rubtcova E, Seward JF, Levin MJ, Schmid DS Little is known about the pathogenic potential of individual strains in the varicella vaccine. We analyzed genomic variation among specimens obtained from vaccine recipients with postvaccination rash or herpes zoster (HZ), focusing on polymorphisms between live attenuated varicella vaccine virus and wild-type varicella-zoster virus. Eleven of 18 postvaccination HZ specimens contained >1 strain, and 7 of 18 appeared to be clonal. All 21 postvaccination rash specimens contained mixtures of vaccine strains. Four single-nucleotide polymorphisms (SNPs) consistently occurred in every isolate; all were polymorphisms in open-reading frame (ORF) 62, and 2 confer amino acid substitutions in the immediate-early protein 62. Four wi... Herpes journals http://www.medworm.com/rss/comments.php?id=360651 Sat, 20 Jan 2007 04:18:02 +0100 360651 http://www.medworm.com/index.php?rid=359585&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17228266%26dopt%3DAbstract CONCLUSION: We demonstrate effective adenoviral-mediated gene transfer into the brain of dogs in vivo and support the use of these vectors to develop an efficacy trial for canine GBM as a prelude to human trials. PMID: 17228266 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=359585 Fri, 19 Jan 2007 06:38:02 +0100 359585 http://www.medworm.com/index.php?rid=358559&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16923583%26dopt%3DAbstract Authors: Celkan T, Ozkan A, Apak H, Yildiz I PMID: 16923583 [PubMed - indexed for MEDLINE] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=358559 Thu, 18 Jan 2007 20:00:02 +0100 358559 http://www.medworm.com/index.php?rid=358558&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17227688%26dopt%3DAbstract CONCLUSIONS: Both vaccine potencies were generally well tolerated in this study of people >/=50 years of age. Although rates of some moderate or severe injection-site AEs were greater in the higher potency group, all rates met the prespecified criteria for clinically acceptable tolerability. PMID: 17227688 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=358558 Thu, 18 Jan 2007 20:00:02 +0100 358558 http://www.medworm.com/index.php?rid=358557&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17227866%26dopt%3DAbstract Authors: Lenschow DJ, Lai C, Frias-Staheli N, Giannakopoulos NV, Lutz A, Wolff T, Osiak A, Levine B, Schmidt RE, García-Sastre A, Leib DA, Pekosz A, Knobeloch KP, Horak I, Virgin HW Type I interferons (IFNs) play an essential role in the host response to viral infection through the induction of numerous IFN-stimulated genes (ISGs), including important antiviral molecules such as PKR, RNase L, Mx, and iNOS. Yet, additional antiviral ISGs likely exist. IFN-stimulated gene 15 (ISG15) is a ubiquitin homolog that is rapidly up-regulated after viral infection, and it conjugates to a wide array of host proteins. Although it has been hypothesized that ISG15 functions as an antiviral molecule, the initial evaluation of ISG15-deficient mice revealed no defects in their responses to vesicular st... Herpes journals http://www.medworm.com/rss/comments.php?id=358557 Thu, 18 Jan 2007 20:00:02 +0100 358557 http://www.medworm.com/index.php?rid=358556&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17228053%26dopt%3DAbstract DISCUSSION: Pathogen burden showed an association with fat mass. Subjects with increased fat mass could be more susceptible to developing multiple infections resulting in a chronic low-grade inflammation. We can not exclude the possibility that exposure to multiple infections leads to increased fat mass. PMID: 17228053 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=358556 Thu, 18 Jan 2007 20:00:02 +0100 358556