MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Herpes' source. Wed, 08 Feb 2012 18:15:41 +0100 http://www.medworm.com/index.php?rid=5607415&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22241695%26dopt%3DAbstract Authors: Abstract A short cut review was carried out to establish whether pregabalin can reduce acute herpetic pain and reduce post herpetic neuralgia. 48 papers were found using the reported searches, of which one presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of this best paper are tabulated. It is concluded that pregabalin does not seem to decrease the intensity of pain related to acute herpes zoster. Moreover, it does not decrease the incidence of post herpetic neuralgia. More research is. PMID: 22241695 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5607415 Fri, 20 Jan 2012 03:32:23 +0100 5607415 http://www.medworm.com/index.php?rid=5607414&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22241800%26dopt%3DAbstract Conclusions. Modifiable risk factors for HIV-1 transmission were plasma HIV-1 RNA level and condom use, and, in HIV-1-uninfected partners, herpes simplex virus 2 infection, genital ulcers, Trichomonas vaginalis, vaginitis or cervicitis, and male circumcision. PMID: 22241800 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5607414 Fri, 20 Jan 2012 03:32:13 +0100 5607414 http://www.medworm.com/index.php?rid=5607412&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22246832%26dopt%3DAbstract Authors: Chaillon A, Schnepf N, Jonas M, Mondon K, Orain I, Lioger B, Cottier JP, Hommet C, Goudeau A Abstract Herpes simplex virus (HSV) infection is rarely considered in the differential diagnosis of severe acute hepatitis and disseminated infection in immunocompetent adults. A case of disseminated HSV-1 infection in an 82-year-old woman initially presenting with neurological problems, signs of meningitis and prominent hepatitis was investigated. Initial diagnosis, monitoring, and follow-up were based on the application of molecular methods to cerebrospinal fluid, serum, and liver tissue samples from this patient. Following an initial full recovery, the patient presented delayed intracerebral haemorrhage and diffuse arthralgia. This atypical case, with delayed secondary progressi... Herpes journals http://www.medworm.com/rss/comments.php?id=5607412 Fri, 20 Jan 2012 03:31:54 +0100 5607412 http://www.medworm.com/index.php?rid=5607410&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22249302%26dopt%3DAbstract CONCLUSION: : More than half of the couples were discordant for HIV, HPV, and/or HSV-2, indicating that prevention strategies directed to infected cases are important to protect their uninfected sexual partners. PMID: 22249302 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5607410 Fri, 20 Jan 2012 03:31:34 +0100 5607410 http://www.medworm.com/index.php?rid=5607409&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22249305%26dopt%3DAbstract CONCLUSION:: HSV-2 seroprevalence is 3 times as high among HIV-infected adults as in the general US population. Clinicians should be aware that increased risk for HSV-2 infection was distributed broadly among HIV-infected persons and not limited to those with high-risk sexual behaviors. PMID: 22249305 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5607409 Fri, 20 Jan 2012 03:31:23 +0100 5607409 http://www.medworm.com/index.php?rid=5607407&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22250636%26dopt%3DAbstract Conclusion  The most common cutaneous adverse event in our cohort was papulopustular rash, followed by eczema and xerosis. Patients were managed with symptom target therapy, and suspension of the EGFR inhibitor was rarely required. As the use of EGFR inhibitors increases, it is important to promptly identify and treat adverse events. Further studies are necessary to develop targeted therapeutic and preventative measures. PMID: 22250636 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5607407 Fri, 20 Jan 2012 03:31:03 +0100 5607407 http://www.medworm.com/index.php?rid=5607408&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22250036%26dopt%3DAbstract CONCLUSION: Study suggests TENS may be safe adjunct or even alternative to antiviral drugs for treatment of acute HZ. It looks that TENS may be at least as good as antiviral drugs for treatment of HZ, and it may be better in reducing and preventing PHN - such conclusion would necessitate controlled, prospective study. Use of TENS provided pain relief and resolution of skin lesions with no higher rate of other HZ complications compared to antiviral therapy. PMID: 22250036 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5607408 Fri, 20 Jan 2012 03:30:02 +0100 5607408 http://www.medworm.com/index.php?rid=5607406&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22251837%26dopt%3DAbstract We report an immunocompetent patient with methicillin-resistant Staphylococcus aureus (MRSA) and Herpes simplex virus (HSV) pneumonia secondary to S-OIV infection. A 57-year-old man previously without major medical illness was admitted to our hospital with severe pneumonia accompanied by ARDS due to S-OIV. In his clinical course, anti-influenza treatment was not effective. Sputum culture revealed the presence of MRSA, and HSV was isolated in broncho-alveoler lavage (BAL) fluid. Administration of an antiviral agent (acyclovir), an antibacterial agent (linezolid), and a corticosteroid (methylprednisolone) successfully improved the pneumonia and ARDS. HSV pneumonia can scarcely be seen in healthy people. However recently it has been recognized as a ventilator-associated pneumonia. Although co... Herpes journals http://www.medworm.com/rss/comments.php?id=5607406 Fri, 20 Jan 2012 03:30:02 +0100 5607406 http://www.medworm.com/index.php?rid=5607405&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22251972%26dopt%3DAbstract In this study, we examined the mechanism of this effect and found that input virion transactivator protein, virion protein 16 (VP16), targets sites adjacent to the nuclear lamina and is required for targeting of the HSV genome to the nuclear lamina, exclusion of heterochromatin from viral replication compartments, and reduction of heterochromatin on the viral genome. Because cells infected with the VP16 mutant virus in1814 showed a phenotype similar to that of lamin A/C(-/-) cells infected with wild-type virus, we hypothesized that the nuclear lamina is required for VP16 activator complex formation. In lamin A/C(-/-) mouse embryo fibroblasts, VP16 and Oct-1 showed reduced association with the viral IE gene promoters, the levels of VP16 and HCF-1 stably associated with the nucleus were lowe... Herpes journals http://www.medworm.com/rss/comments.php?id=5607405 Fri, 20 Jan 2012 03:30:02 +0100 5607405 http://www.medworm.com/index.php?rid=5607402&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22254152%26dopt%3DAbstract Authors: Galeone M, Colucci R, D'Erme AM, Moretti S, Lotti T Abstract Behçet's disease is a multisystem inflammatory disorder characterized by recurrent oral aphthous ulcers, genital ulcers, uveitis, and skin lesions. The cause of Behçet's disease remains unknown, but epidemiologic findings suggest that an autoimmune process is triggered by an environmental agent in a genetically predisposed individual. An infectious agent could operate through molecular mimicry, and subsequently the disease could be perpetuated by an abnormal immune response to an autoantigen in the absence of ongoing infection. Potentia bacterial are Saccharomyces cerevisiae, mycobacteria, Borrelia burgdorferi, Helicobacter pylori, Escherichia coli, Staphylococcus aureus, and Mycoplasma fermentans, but the most... Herpes journals http://www.medworm.com/rss/comments.php?id=5607402 Fri, 20 Jan 2012 03:30:02 +0100 5607402 http://www.medworm.com/index.php?rid=5607403&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22252837%26dopt%3DAbstract Authors: Alvarez G, Aldudo J, Alonso M, Santana S, Valdivieso F Abstract Herpes simplex virus type 1 (HSV-1) is a neurotropic virus that remains latent in host neurons. Viral DNA replication is a highly structured process in which the redistribution of nuclear proteins plays an important role. Although tau is most widely known as a microtubule-associated protein found in a hyperphosphorylated state in the brains of patients with Alzheimer's disease (AD), this protein has also been detected at other sites such as the nucleolus. Here, we establish that HSV-1 infection gives rise to an increase in tau phosphorylation and that hyperphosphorylated tau accumulates in the nucleus, forming defined structures in HSV-1-infected neuronal cells reminiscent of the common sites of viral DNA repl... Herpes journals http://www.medworm.com/rss/comments.php?id=5607403 Wed, 18 Jan 2012 05:00:00 +0100 5607403 http://www.medworm.com/index.php?rid=5607404&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22252570%26dopt%3DAbstract CONCLUSIONS: This work stresses the importance of considering synkinesis and hyperkinesis separately because they are different conditions. These two symptoms showed improvement after botulinum toxin treatment, but only hyperkinesis showed a positive correlation when objective and subjective evaluations were performed. This treatment is effective in the management of facial synkinesis and hyperkinesis due to facial palsy, thus improving quality of life. It is a safe, minimally invasive treatment that can be repeated. PMID: 22252570 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5607404 Tue, 17 Jan 2012 05:00:00 +0100 5607404 http://www.medworm.com/index.php?rid=5607411&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22248367%26dopt%3DAbstract Authors: Koo T, Choi IK, Kim M, Lee JS, Oh E, Kim J, Yun CO Abstract Intact p53 function is essential for responsiveness to cancer therapy. However, p53 activity is attenuated by the proto-oncoprotein Mdm2, the adenovirus protein E1B-55kD, and the p53 C-terminal domain. To confer resistance to Mdm2, E1B-55kD, and C-terminal negative regulation, we generated a p53 variant (p53VPΔ30) by deleting the N-terminal and C-terminal regions of wild-type (wt) p53 and inserting the transcriptional activation domain of herpes simplex virus VP16 protein. The oncolytic adenovirus vector Ad-mΔ19 expressing p53VPΔ30 (Ad-m19/p53VPΔ30) showed greater cytotoxicity than Ad-mΔ19 expressing wt p53 or other p53 variants in human cancer cell lines. We found that Ad-m∆19/p53VPΔ30 induced apopt... Herpes journals http://www.medworm.com/rss/comments.php?id=5607411 Mon, 16 Jan 2012 05:00:00 +0100 5607411 http://www.medworm.com/index.php?rid=5607413&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22243919%26dopt%3DAbstract CONCLUSIONS: This study shows that Alaskan reindeer and Caribou are infected with an alphaherpesvirus. Based on sequence similarity, CvHV-2 is the most likely virus. Further studies should be conducted to determine the impact of this infection on the health of these animals. PMID: 22243919 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5607413 Sat, 14 Jan 2012 05:00:00 +0100 5607413 http://www.medworm.com/index.php?rid=5580608&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22223838%26dopt%3DAbstract Conclusions The association of HIV status with younger age at sexual debut may likely due to an increased number of lifetime partners. This increase could result from longer duration of sexual life. Prevention of HIV infection should include efforts to delay age at first sex in young women. Trial registration number NCT00121459. PMID: 22223838 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5580608 Fri, 13 Jan 2012 11:30:16 +0100 5580608 http://www.medworm.com/index.php?rid=5580603&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22230451%26dopt%3DAbstract Authors: Gomez-Manzano C, Jiang H, Alonso M, Yung WK, Fueyo J Abstract During the last 10 years, gene therapy for brain tumors has known peaks and valleys. The first attempts to induce therapeutic effect, using retrovirus to transduce the HSV-TK gene and adenovirus to transfer wild-type p53 cDNA, failed significantly to improve the survival of the patients. In both cases, the failure was attributed to vector deficiencies, also termed the 'vector gap'. To address the problem of delivery, investigators have moved from replication-deficient vectors to replication-competent, tumor-selective viruses. These viruses are currently being tested in the clinical setting. In this review, we discuss the progress made with herpes simplex viruses (G207), reoviruses that naturally target Ras pathw... Herpes journals http://www.medworm.com/rss/comments.php?id=5580603 Fri, 13 Jan 2012 11:30:16 +0100 5580603 http://www.medworm.com/index.php?rid=5580602&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22230539%26dopt%3DAbstract Authors: Marosi C Abstract The persisting reservation against the use of chemotherapy in patients with malignant glioma was finally overcome by the breakthrough achieved with the use of the oral alkylating agent temozolomide (TMZ) as concomitant and adjuvant chemotherapy in patients with newly diagnosed glioblastoma multiforme (GBM). The basic condition for an effective systemic drug therapy against malignant glioma is that the drug be able to cross the blood-brain barrier (BBB) and the brain-tumor barrier. Drugs crossing the BBB have to be nonpolar, small molecules with a molecular weight of less than 500Da, to bear no electrical charge, or to be able to use active transport mechanisms, as the BBB is functional in the peripheral growing areas of GBM. The prerequisite of liposolubi... Herpes journals http://www.medworm.com/rss/comments.php?id=5580602 Fri, 13 Jan 2012 11:30:16 +0100 5580602 http://www.medworm.com/index.php?rid=5580598&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22235269%26dopt%3DAbstract CONCLUSIONS AND SIGNIFICANCE: As in the blood and muscle, DM skin is characterized by an overwhelming presence of an IFN signature, although it is difficult to conclusively define this response as type I or type II. Understanding the significance of the IFN signature in this wide array of inflammatory diseases will be furthered by identification of the nature of the cells that both produce and respond to IFN, as well as which IFN subtype is biologically active in each diseased tissue. PMID: 22235269 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5580598 Fri, 13 Jan 2012 11:30:16 +0100 5580598 http://www.medworm.com/index.php?rid=5580597&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22236740%26dopt%3DAbstract Authors: Michelow P, Wright C, Pantanowitz L Abstract The Epstein-Barr virus (EBV) is a member of the herpes family of viruses and is very common in humans. EBV is most often associated with infectious mononucleosis. However, it is estimated that 1% of tumors including lymphoproliferative, epithelial and mesenchymal are linked to EBV infection. EBV has a tropism for certain epithelial cells, lymphocytes and myocytes. Like other herpesviruses, EBV has both lytic and latent phases of infection. In the latent form, EBV-encoded genes ensure the survival of the viral genome, allowing it to circumvent the host's immune surveillance by limited expression of viral proteins and carries with it the risk of neoplastic transformation. Cytologists are likely to encounter EBV-associated malignan... Herpes journals http://www.medworm.com/rss/comments.php?id=5580597 Fri, 13 Jan 2012 11:30:16 +0100 5580597 http://www.medworm.com/index.php?rid=5580596&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22236996%26dopt%3DAbstract We report that TLR signaling is expendable in herpes simplex virus (HSV)-1 containment as depicted by plaque assays of knockout mice (MyD88(-/-), Trif(-/-) and MyD88(-/-) Trif(-/-) double knockout) resembling wild-type controls. To identify the key sentinel in viral recognition of the cornea, in vivo knockdown of the DNA sensor IFI-16/p204 in the corneal epithelium was performed and resulted in a loss of IFN-regulatory factor-3 (IRF-3) nuclear translocation, interferon-α production, and viral containment. The sensor seems to have a similar function in other HSV clinically relevant sites such as the vaginal mucosa in which a loss of p204/IFI-16 results in significantly more HSV-2 shedding. Thus, we have identified an IRF-3-dependent, IRF-7- and TLR-independent innate sensor responsible for... Herpes journals http://www.medworm.com/rss/comments.php?id=5580596 Wed, 11 Jan 2012 05:00:00 +0100 5580596 http://www.medworm.com/index.php?rid=5580605&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22229804%26dopt%3DAbstract Conclusion:  These data imply that enveloped virus can deviate Th2 responses in human cord T-cells. PMID: 22229804 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5580605 Tue, 10 Jan 2012 05:00:00 +0100 5580605 http://www.medworm.com/index.php?rid=5580604&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22230041%26dopt%3DAbstract In conclusion, both diseases cause a substantial burden in Belgium. PMID: 22230041 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5580604 Tue, 10 Jan 2012 05:00:00 +0100 5580604 http://www.medworm.com/index.php?rid=5580600&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22233252%26dopt%3DAbstract Authors: Gnazzo V, Cebrian I, Langellotti C, Chabalgoity J, Mongini C, Quattrocchi V, Zamorano P Abstract Abstract A live system to release heterologous antigens using an attenuated Salmonella strain was developed. We transformed Salmonella typhimurium LVR03 (S. LVR03) with a recombinant pTECH2 vector encoding 0, 1, 2, and 4 tandem copies of an imunogenic peptide of bovine herpes virus-1 (BoHV-1) glycoprotein D (gD). The system used yielded peptides fused to the non-toxic C fragment of the tetanus toxin (TetC), which has been shown to have adjuvant properties. Inoculation of BALB/c mice with the transformed Salmonella strains gave rise to a mild self-limited infection, with primary replication of bacteria occurring in Peyer's patches, even when the bacteria was administered intran... Herpes journals http://www.medworm.com/rss/comments.php?id=5580600 Tue, 10 Jan 2012 05:00:00 +0100 5580600 http://www.medworm.com/index.php?rid=5580599&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22233258%26dopt%3DAbstract Authors: Galeone M, Berti S, Zamma B, De Martino M, Arunachalam M, Colucci R, Moretti S PMID: 22233258 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5580599 Tue, 10 Jan 2012 05:00:00 +0100 5580599 http://www.medworm.com/index.php?rid=5580595&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22237001%26dopt%3DAbstract CONCLUSIONS: Anti-inflammatory intervention may only be effective if it is undertaken during the early phase of disseminated neonatal HSV infections. PMID: 22237001 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5580595 Mon, 09 Jan 2012 05:00:00 +0100 5580595 http://www.medworm.com/index.php?rid=5580601&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22230658%26dopt%3DAbstract Authors: Schuppers ME, Stegeman JA, Kramps JA, Stärk KD Abstract International trade of livestock and livestock products poses a significant potential threat for spread of diseases, and importing countries therefore often require that imported animals and products are free from certain pathogens. However, absolute freedom from infection cannot be documented, since all test protocols are imperfect and can lead to false-negative results. It is possible instead to estimate the "probability of freedom from infection" and its opposite, the probability of infection despite having a negative test result. These probabilities can be estimated based on a pre-defined target prevalence, known surveillance efforts in the target population and known test characteristics of any pre-export test. ... Herpes journals http://www.medworm.com/rss/comments.php?id=5580601 Sat, 07 Jan 2012 05:00:00 +0100 5580601 http://www.medworm.com/index.php?rid=5580610&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22220560%26dopt%3DAbstract Authors: Tranel D, Welsh-Bohmer KA Abstract What pattern of brain damage could completely obliterate the sense of olfaction in humans? We had an opportunity to address this intriguing question in Patient B., who has extensive bilateral damage to most of the limbic system, including the medial and lateral temporal lobes, orbital frontal cortex, insular cortex, anterior cingulate cortex, and basal forebrain, caused by herpes simplex encephalitis. The patient demonstrated profound impairments in odor identification and recognition. Moreover, he could not discriminate between olfactory stimuli, and he had severe impairments in odor detection. Reliable stimulus detection was obtained only for solutions of the organic solvent acetone and highly concentrated solutions of ethanol. In contr... Herpes journals http://www.medworm.com/rss/comments.php?id=5580610 Fri, 06 Jan 2012 05:00:00 +0100 5580610 http://www.medworm.com/index.php?rid=5580609&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22222893%26dopt%3DAbstract Authors: Blake JA, Bareiss B, Jimenez L, Griffith M, Scaiano JC Abstract We have attached the antiviral drug acyclovir (ACV) to a xanthone photolabile protecting group (or photocage) through the O6 position of acyclovir, a procedure designed for the treatment of ocular herpes simplex virus infections. Acyclovir is photoreleased from the photocage, under physiological conditions, with a quantum yield (Φ(ACV release)) of 0.1-0.3 and an uncaging cross section (Φ·ε) of 450-1350 M cm(-1). We demonstrate that this photorelease method outcompetes alternative reaction pathways, such as protonation. Furthermore, complete release of the drug is theoretically possible given a sufficient dose of light . Surprisingly the acyclovir photocage, also showed some antiviral activity towards HSV-... Herpes journals http://www.medworm.com/rss/comments.php?id=5580609 Fri, 06 Jan 2012 05:00:00 +0100 5580609 http://www.medworm.com/index.php?rid=5580607&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22225618%26dopt%3DAbstract CONCLUSIONS: While EB did demonstrate some in vivo efficacy against vaccinia in mice, the limited conditions under which it was effective against vaccinia and lack of activity against cowpox suggest EB may be more useful for studying orthopoxvirus entry and attachment in vitro than as a therapeutic against orthopoxviruses in vivo. PMID: 22225618 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5580607 Fri, 06 Jan 2012 05:00:00 +0100 5580607 http://www.medworm.com/index.php?rid=5580606&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22228853%26dopt%3DAbstract This article represents the result of a mutual interaction between human medical science and veterinary science, a combination of scientific knowledge often neglected. PMID: 22228853 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5580606 Fri, 06 Jan 2012 05:00:00 +0100 5580606 http://www.medworm.com/index.php?rid=5569151&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22216840%26dopt%3DAbstract CONCLUSIONS: In a study population that was representative of the general population of HSV-1- and HSV-2-seronegative women, the investigational vaccine was effective in preventing HSV-1 genital disease and infection but not in preventing HSV-2 disease or infection. (Funded by the National Institute of Allergy and Infectious Diseases and GlaxoSmithKline; ClinicalTrials.gov number, NCT00057330.). PMID: 22216840 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5569151 Thu, 05 Jan 2012 05:00:00 +0100 5569151 http://www.medworm.com/index.php?rid=5569150&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22216851%26dopt%3DAbstract Authors: Abstract To the Editor: In their study of oral acyclovir in neonates after herpes simplex virus (HSV) infection, Kimberlin et al. (Oct. 6 issue)(1) describe an initial dose of parenteral acyclovir (300 mg per square meter of body-surface area) that is lower than that used in current clinical practice (1500 mg per square meter) administered for 21 days in cases of central nervous system involvement.(2) In addition, the authors do not mention the possible genetic predisposition to HSV among infants with frequent skin relapses(3) and imply that 6 months of oral prophylaxis may be adequate. In our practice, we see two . . . PMID: 22216851 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5569150 Thu, 05 Jan 2012 05:00:00 +0100 5569150 http://www.medworm.com/index.php?rid=5569155&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22210631%26dopt%3DAbstract Anogenital pseudotumoral herpes and HIV infection: a new challenge for diagnosis and treatment. AIDS. 2012 Jan 4; Authors: Lucca-Chrisment Julie DI, Simon J, Ludivine G, Françoise P, Hélène L, Flore R, Jean-Pierre M, Alexiane D, Marie-Françoise A, Nicolas D Abstract HIV-infected patients may develop rare anogenital pseudotumoral herpes potentially mimicking epidermoid carcinoma. We assessed treatment in five new cases with a median follow-up of 3.3 years. Recurrence and clinical nucleoside analog resistance were observed in all patients. All drug treatments were only temporarily curative and clinical responses varied between patients and recurrences. Foscavir seemed to be the most appropriate second-line treatment and cidofovir or thalidomide should be considered as alt... Herpes journals http://www.medworm.com/rss/comments.php?id=5569155 Wed, 04 Jan 2012 05:00:00 +0100 5569155 http://www.medworm.com/index.php?rid=5569153&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22212157%26dopt%3DAbstract Authors: Potthoff A, Rasokat H, Brockmeyer NH Abstract The skin can be an indicator of decreased immunocompetence. Dermatological markers include new and extensive seborrheic eczema, psoriasis without a family history, widespread herpes zoster in young adults, oral hairy leucoplakia and mollusca in adults. In these cases an HIV test should be offered. During the last 15 years the clinical picture of HIV has changed dramatically. Almost every year new drugs with better efficacy, lower pill burden and less side effects have been approved. Life expectancy is close to normal in western countries. In spite of better treatment options, prevention is the key to stop the worldwide epidemic. Awareness campaigns have to account for the synergies between HIV and other sexually transmitted di... Herpes journals http://www.medworm.com/rss/comments.php?id=5569153 Wed, 04 Jan 2012 05:00:00 +0100 5569153 http://www.medworm.com/index.php?rid=5569154&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22212015%26dopt%3DAbstract Conclusions  A wide range of mucocutaneous disorders were observed in HIV-infected Chinese patients. Oral candidiasis, P. marneffei infection and PPE may be the signs of advanced HIV infection. HAART had an impact on the spectrum of HIV-associated mucocutaneous disorders. PMID: 22212015 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5569154 Tue, 03 Jan 2012 05:00:00 +0100 5569154 http://www.medworm.com/index.php?rid=5569152&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214845%26dopt%3DAbstract Authors: Jing L, Haas J, Chong TM, Bruckner JJ, Dann GC, Dong L, Marshak JO, McClurkan CL, Yamamoto TN, Bailer SM, Laing KJ, Wald A, Verjans GM, Koelle DM Abstract Herpes simplex virus type 1 (HSV-1) not only causes painful recurrent oral-labial infections, it can also cause permanent brain damage and blindness. There is currently no HSV-1 vaccine. An effective vaccine must stimulate coordinated T cell responses, but the large size of the genome and the low frequency of HSV-1-specific T cells have hampered the search for the most effective T cell antigens for inclusion in a candidate vaccine. We have now developed what we believe to be novel methods to efficiently generate a genome-wide map of the responsiveness of HSV-1-specific T cells, and demonstrate the applicability of these ... Herpes journals http://www.medworm.com/rss/comments.php?id=5569152 Tue, 03 Jan 2012 05:00:00 +0100 5569152 http://www.medworm.com/index.php?rid=5569148&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22218240%26dopt%3DAbstract Conclusion: Long-term survival of grafts at our center is different from centers in western world. More high-risk cases, paucity of excellent quality donor corneas, and differences in patient profile could be the contributory factors. PMID: 22218240 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5569148 Sun, 01 Jan 2012 05:00:00 +0100 5569148 http://www.medworm.com/index.php?rid=5284474&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21948465%26dopt%3DAbstract Authors: Agarwalla PK, Aghi MK Abstract Herpes simplex virus-1 (HSV-1) is an enveloped, double-stranded DNA virus that has been used with modification as an oncolytic virus against a number of tumor types. Modifications that make HSV-1 replication--conditional, i.e., selectively divide in replicating cells make it fulfill a prerequisite criteria for oncolytic viruses. Other appealing features of HSV-1 as an oncolytic virus include its large, modifiable genome; its sensitivity to antiviral agents, such as ganciclovir; and its lack of host cell integration. Here, we review the methods of HSV-1 engineering, through traditional recombination techniques as well as through bacterial artificial chromosome (BAC) technology. We then describe protocols for titering, amplification, and purifi... Herpes journals http://www.medworm.com/rss/comments.php?id=5284474 Wed, 05 Oct 2011 18:20:32 +0100 5284474 http://www.medworm.com/index.php?rid=5284473&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21893380%26dopt%3DAbstract Authors: Lee D, Ahn TB PMID: 21893380 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5284473 Wed, 05 Oct 2011 18:20:13 +0100 5284473 http://www.medworm.com/index.php?rid=5221805&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21915882%26dopt%3DAbstract The objective of this study was to investigate whether patients on TNF-α inhibitors who developed herpes zoster have a lower incidence of subsequent development of postherpetic neuralgia. A retrospective review of herpes zoster patients on TNF-α inhibitors (infliximab, etanercept, or adalimumab) was conducted in 12 dermatology clinics. Medical records of such patients were reviewed thoroughly to confirm herpes zoster and TNF-α inhibitors and any subsequent development of postherpetic neuralgia (pain score ≥3 out of 10 after 90 days of shingles onset) was noted. A total of 206 cases were reviewed, of which only 2 cases (<1%) developed postherpetic neuralgia, a considerably lower incidence rate than noted in the literature. Increasing age is a known risk factor in the development of ... Herpes journals http://www.medworm.com/rss/comments.php?id=5221805 Fri, 16 Sep 2011 03:52:13 +0100 5221805 http://www.medworm.com/index.php?rid=5143671&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21837784%26dopt%3DAbstract Authors: Macleod IJ, O'Donnell B, Moyo S, Lockman S, Shapiro RL, Kayembe M, van Widenfelt E, Makhema J, Essex M, Wester C Abstract Human papillomaviruses (HPV) constitute one of the most prevalent sexually transmitted infections and are the etiological agents for invasive cervical cancer, the predominant cancer among women in Botswana. However, the prevalence of HPV genotypes in Botswana has yet to be reported. One hundred thirty-nine endocervical swabs were taken at baseline from HIV-1 infected, HSV-2 seropositive women enrolled in a longitudinal cohort study designed to assess the influence of herpes simplex virus-2 (HSV-2) infection on genital tract shedding of HIV-1. Extracted DNA was evaluated for the presence of low-risk and high-risk HPV using the Roche Linear Array. Genotyp... Herpes journals http://www.medworm.com/rss/comments.php?id=5143671 Sat, 20 Aug 2011 14:32:41 +0100 5143671 http://www.medworm.com/index.php?rid=5143670&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21844022%26dopt%3DAbstract Conclusions. This study failed to demonstrate an increased risk or earlier onset of zoster in members of CMO not exposed to VZV, compared with that in the GP. Although adults highly exposed to VZV could have a reduced risk of zoster, compared with the GP, our results suggest that the opposite is not true: adults not exposed to VZV are not at increased risk of zoster when compared with the GP, challenging the relevance of the assumptions and forecasts of current epidemiological models. PMID: 21844022 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5143670 Sat, 20 Aug 2011 14:32:35 +0100 5143670 http://www.medworm.com/index.php?rid=5143669&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21844733%26dopt%3DAbstract CONCLUSIONS: : Subjects' preferences are influenced by both the treatment they follow and attributes of treatment including cost. Knowledge of patients' preferences, together with their clinical status, could help decision-makers to optimize therapy uptake and success. PMID: 21844733 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5143669 Sat, 20 Aug 2011 14:32:30 +0100 5143669 http://www.medworm.com/index.php?rid=5143668&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21844739%26dopt%3DAbstract Authors: Sandlin MI, Johnston C, Bowe D, Saracino M, Schacker T, Shaughnessy M, Corey L, Wald A Abstract Anogenital ulcers caused by herpes simplex virus type 2 (HSV-2) are associated with an increased risk of human immunodeficiency virus (HIV) transmission. When compared with clinician examination, HIV/HSV-2 coinfected men who have sex with men are frequently unaware of anogenital ulcers. These data highlight the importance of condom use and the need for new HSV-2 prevention strategies. PMID: 21844739 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5143668 Sat, 20 Aug 2011 14:32:26 +0100 5143668 http://www.medworm.com/index.php?rid=5143667&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21844740%26dopt%3DAbstract CONCLUSIONS: : HSV-2 incidence in these men and women is among the highest reported, and is associated with HIV-1 acquisition. Although vaginal washing with soap may increase HSV-2 risk in women, genital hygiene may be protective in men. PMID: 21844740 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5143667 Sat, 20 Aug 2011 14:32:20 +0100 5143667 http://www.medworm.com/index.php?rid=5143649&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21844743%26dopt%3DAbstract CONCLUSIONS:: Interventions to help shorten the duration between ulcer recognition and health care seeking for men with GUD are needed. PMID: 21844743 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5143649 Sat, 20 Aug 2011 14:32:15 +0100 5143649 http://www.medworm.com/index.php?rid=5143648&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21849278%26dopt%3DAbstract Authors: Nagel MA, Choe A, Cohrs RJ, Traktinskiy I, Sorensen K, Mehta SK, Pierson DL, Tyring SK, Haitz K, Digiorgio C, Lapolla W, Gilden D Abstract (See the editorial commentary by Gershon, on pages 815-6.) Analysis of saliva samples from individuals aged ≥60 years who had a history of zoster (group 1), zoster and postherpetic neuralgia (PHN; group 2), or no history of zoster (group 3) revealed varicella zoster virus (VZV) DNA in saliva samples from 11 of 17 individuals in group 1, 10 of 15 individuals in group 2, and 2 of 17 individuals in group 3. The frequency of VZV DNA detection was significantly higher (P = .001) in saliva of subjects with a history of zoster, with or without PHN (21 [67%] of 32 subjects in groups 1 and 2), than in saliva of age-matched subjects with no zos... Herpes journals http://www.medworm.com/rss/comments.php?id=5143648 Sat, 20 Aug 2011 14:32:08 +0100 5143648 http://www.medworm.com/index.php?rid=5021789&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21729172%26dopt%3DAbstract We describe a patient who had two consecutive episodes of PEM related to two different triggers: paroxetine and HSV infection. In the first episode, systemic photosensitivity was confirmed with the photobiological study. UVB-MED was decreased when the patient was taking paroxetine and did not change after its substitution for duloxetine. However, it became normal after the withdrawal of both drugs, suggesting a cross-reactivity reaction. The UVB photopatch test with paroxetine was positive. The second episode occurred after a herpes labialis relapse. At that time, UVB-MED was normal. PMID: 21729172 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5021789 Wed, 13 Jul 2011 17:48:04 +0100 5021789 http://www.medworm.com/index.php?rid=5021764&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21742133%26dopt%3DAbstract Authors: Chan D, Tarbin J, Sharman M, Carson M, Smith M, Smith S A screening method for the analysis of seven anti-viral drugs in poultry tissue has been developed. These include anti-influenza drugs (amantadine, rimantadine, zanamivir and oseltamivir and its carboxylate metabolite), anti-herpes drugs (acyclovir and ganciclovir) and an immunomodulator (imiquimod). Poultry tissue was extracted in acetonitrile:water:acetic acid. After sample purification, using a strong cation exchange column, the eluate was split into two fractions. The first portion was dissolved in methanol:water and the second in acetonitrile:methanol:water. Both fractions were analysed on a zwitterionic hydrophilic interaction liquid chromatography column coupled to a triple quadrupole mass spectrometer. The screeni... Herpes journals http://www.medworm.com/rss/comments.php?id=5021764 Wed, 13 Jul 2011 17:45:46 +0100 5021764 http://www.medworm.com/index.php?rid=5021758&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21748716%26dopt%3DAbstract Authors: Villanueva-Perez VL, Palmisani S, Asensio-Samper JM, Fabregat-Cid G, de Andres-Ibanez JA PMID: 21748716 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5021758 Wed, 13 Jul 2011 17:45:08 +0100 5021758 http://www.medworm.com/index.php?rid=5021814&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21712983%26dopt%3DAbstract Authors: Shebl FM, Dollard SC, Pfeiffer RM, Biryahwaho B, Amin MM, Munuo SS, Hladik W, Parsons R, Graubard BI, Mbulaiteye SM Sexual transmission of human herpesvirus 8 (HHV8) has been implicated among homosexual men, but the evidence for sexual transmission among heterosexual individuals is controversial. We investigated the role of sexual transmission of HHV8 in a nationally representative sample in Uganda, where HHV8 infection is endemic and transmitted mostly during childhood. PMID: 21712983 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5021814 Wed, 13 Jul 2011 17:45:03 +0100 5021814 http://www.medworm.com/index.php?rid=5021812&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21713076%26dopt%3DAbstract Authors: Breccia M, Girmenia C, Latagliata R, Loglisci G, Santopietro M, Federico V, Petrucci L, Serrao A, Salaroli A, Alimena G Imatinib has become first line therapy in chronic myeloid leukemia patients. Little is known about the infective consequences during the treatment with this drug in large series of chronic phase patients. PMID: 21713076 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5021812 Wed, 13 Jul 2011 17:45:03 +0100 5021812 http://www.medworm.com/index.php?rid=5021811&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21716710%26dopt%3DAbstract Authors: Shimizu T, Takeshita Y, Takamori Y, Kai H, Sawamura R, Yoshida H, Watanabe W, Tsutsumi A, Park YK, Yasukawa K, Matsuno K, Shiraki K, Kurokawa M Ethanol extracts (AF-06, 07, and 08, 10 mg/kg) of Brazilian propolis were administered orally to cutaneously herpes simplex virus type 1 (HSV-1)-infected mice three times daily on days 0 to 6 after infection to evaluate their efficacies against HSV-1 infection and significantly limited development of herpetic skin lesions. AF-07 and 08 significantly reduced virus titers in brain and/or skin on day 4 without toxicity, but AF-08 had no anti-HSV-1 activity in vitro. AF-06 and 08 significantly enhanced delayed-type hypersensitivity (DTH) to inactivated HSV-1 antigen in infected mice. Oral AF-08-administration significantly augmented inte... Herpes journals http://www.medworm.com/rss/comments.php?id=5021811 Wed, 13 Jul 2011 17:45:03 +0100 5021811 http://www.medworm.com/index.php?rid=5021786&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21730369%26dopt%3DAbstract Authors: Benci K, Suhina T, Mandić L, Pavelić SK, Paravić AT, Pavelić K, Balzarini J, Wittine K, Mintas M Several published studies indicate that the acyclic guanine nucleoside analogues possessing bis(1,2-hydroxymethyl) substituted cyclopropane rings mimicking the sugar moiety are potent inhibitors of replication of several herpes viruses. PMID: 21730369 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5021786 Wed, 13 Jul 2011 17:45:03 +0100 5021786 http://www.medworm.com/index.php?rid=5021774&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21738672%26dopt%3DAbstract Authors: Ill-Raga G, Palomer E, Wozniak MA, Ramos-Fernández E, Bosch-Morató M, Tajes M, Guix FX, Galán JJ, Clarimón J, Antúnez C, Real LM, Boada M, Itzhaki RF, Fandos C, Muñoz FJ BACE1 is a key enzyme involved in the production of amyloid ß-peptide (Aß) in Alzheimer's disease (AD) brains. Normally, its expression is constitutively inhibited due to the presence of the 5'untranslated region (5'UTR) in the BACE1 promoter. BACE1 expression is activated by phosphorylation of the eukaryotic initiation factor (eIF)2-alpha, which reverses the inhibitory effect exerted by BACE1 5'UTR. There are four kinases associated with different types of stress that could phosphorylate eIF2-alpha. Here we focus on the double-stranded (ds) RNA-activated protein kinase (PKR). PKR is activated during v... Herpes journals http://www.medworm.com/rss/comments.php?id=5021774 Wed, 13 Jul 2011 17:45:03 +0100 5021774 http://www.medworm.com/index.php?rid=5021762&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21745774%26dopt%3DAbstract We report the case of a male, 80-year-old resident in the City of Buenos Aires, with a diagnosis of St. Louis encephalitis (SLE) during a countrywide dengue outbreak, from January to May 2009. The patient had a chronic lymphocytic leukemia treated with chlorambucil, prostate cancer (hormone therapy and radiotherapy) and images consistent with bone metastases. Cerebrospinal fluid examination showed pleocytosis with a predominance of mononuclear cells and high protein concentration. Bacteria, fungi and mycobacteria cultures, as well as the PCR for herpes virus, HSV, CMV and EBV, were negative. We confirmed the diagnosis of SLE by detection of IgM antibodies in both CSF and serum sample with IgG seroconversion by neutralization in cell cultures and negative results for other flaviviruses with... Herpes journals http://www.medworm.com/rss/comments.php?id=5021762 Wed, 13 Jul 2011 17:45:03 +0100 5021762 http://www.medworm.com/index.php?rid=5021761&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21747842%26dopt%3DAbstract We report an adult female patient who presented with sacral radiculopathy as incapacitating dysthesias following primary genital herpes simplex, which later recurred. Despite use of systemic antiviral treatment, the painful syndrome in our patient persisted. The success in treatment was seen only after the addition of amitriptyline hydrochloride. The case is being presented here for its rare manifestation and novel use of amitriptyline hydrochloride. PMID: 21747842 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5021761 Wed, 13 Jul 2011 17:45:03 +0100 5021761 http://www.medworm.com/index.php?rid=5021760&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21748316%26dopt%3DAbstract We report the case of a 24-year gravida 4 para 2 with singleton pregnancy admitted to obstetrical unit for fever up to 38°C during the 20th week of a so far uncomplicated pregnancy. Ultrasound examination and urine test was inconspicuous. Throat complaints were initially relieved during antibiotic therapy, but the patient developed dyspnea with progressing signs of cyanosis. Intubation was necessary on the fifth day because of decreasing oxygen saturation. Coincidentally, progressive pancytopenia and increased inflammatory activity was recorded. Echocardiography, blood cultures, and bronchial lavage brought no pathological findings, but CT revealed acute respiratory distress syndrome and hepatomegaly. Recent human immunodeficiency virus, cytomegalic virus, herpes simplex virus, classical ... Herpes journals http://www.medworm.com/rss/comments.php?id=5021760 Mon, 11 Jul 2011 23:00:00 +0100 5021760 http://www.medworm.com/index.php?rid=5021759&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21748360%26dopt%3DAbstract This study investigated the influence of Hp genetic polymorphism on the development of KS in HIV-positive patients. 661 HIV patients were enrolled in the study with a median age of 35 years and a median follow-up time of 57 months. Hp phenotyping was performed using hemoglobin-supplemented starch gel electrophoresis. In case of low Hp concentration high pressure gel permeation chromatography (HPGPC) was used. The Hp 1-1 phenotype was associated with a significant higher risk of KS compared to the combined group of Hp 2-1 and Hp 2-2 patients (p < 0.0005) which remained significant after adjustment for possible confounding variables (age, gender and AIDS status) (p < 0.001). In contrast, the Hp 2-1 phenotype carried the lowest risk. These findings point to the involvement of Hp p... Herpes journals http://www.medworm.com/rss/comments.php?id=5021759 Mon, 11 Jul 2011 23:00:00 +0100 5021759 http://www.medworm.com/index.php?rid=5021766&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21740480%26dopt%3DAbstract Authors: Amodio E, Goedert JJ, Barozzi P, Riva G, Firenze A, Bonura F, Viviano E, Romano N, Luppi M Kaposi sarcoma (KS) may develop because of incompetent immune responses, both nonspecifically and specifically against the KS-associated herpes virus (KSHV). Peripheral blood mononuclear cells from 15 classic (non-AIDS) KS cases, 13 KSHV seropositives (without KS), and 15 KSHV-seronegative controls were tested for interferon-γ T-cell (Elispot) responses to KSHV-LANA, KSHV-K8.1, and CMV/EBV peptide pools. The forearm and thigh of each participant also was tested for delayed-type hypersensitivity (DTH) against common recall antigens. Groups were compared with Fisher exact test and multinomial logistic regression to calculate odds ratios (OR) and 95% confidence intervals (CI). KSHV Elispot... Herpes journals http://www.medworm.com/rss/comments.php?id=5021766 Fri, 08 Jul 2011 23:00:00 +0100 5021766 http://www.medworm.com/index.php?rid=5021773&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21740353%26dopt%3DAbstract This article also describes the approaches to enhance the antitumor immunity of oncolytic HSVs, and in particular, the key role played by integrating membrane-fusion activity into these viruses. Additionally, this article reviews the potential effect of certain chemotherapeutic agents (e.g. cyclophosphamide) in boosting antitumor immunity induced by oncolytic HSV, and the mechanisms behind it. In summary, all the preclinical and clinical data have suggested that HSV-based oncolytic virotherapies could likely be developed as a new generation of cancer vaccines for the treatment of solid tumors. PMID: 21740353 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5021773 Thu, 07 Jul 2011 23:00:00 +0100 5021773 http://www.medworm.com/index.php?rid=5021772&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21740355%26dopt%3DAbstract Authors: Tong AW, Senzer N, Cerullo V, Templeton NS, Hemminki A, Nemunaitis J Oncolytic virotherapy is an evolving but, as yet, unrealized treatment option for cancer. This approach harnesses the cancer-restricted replicative activity of engineered viruses to achieve tumor cell kill. Tumors that are resistant to chemotherapy or radiotherapy can be susceptible to viral oncolysis because of distinct cell kill mechanisms. There is now compelling evidence that collateral induction of anti-tumor immune responses contributes substantially to viral anti-tumor activities. In addition to the expected anti-viral immune clearance, the "danger" signal created by virus-infected cells can generate immune co-stimulation known to override immune suppression and reverse tolerance within the tumor micro... Herpes journals http://www.medworm.com/rss/comments.php?id=5021772 Thu, 07 Jul 2011 23:00:00 +0100 5021772 http://www.medworm.com/index.php?rid=5021771&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21740356%26dopt%3DAbstract Authors: Menotti L, Campadelli-Fiume G, Nanni P, Lollini PL, De Giovanni C Herpes simplex viruses (HSVs) have entered clinical trials as oncolytic agents. The following properties make them good candidates. It is a mild pathogen; drugs (Aciclovir) are available to control viral infection; the large genome is amenable to genetic engineering, they can be rendered cancer-specific by deletion of genes, envelope glycoproteins allow the insertion of heterologous ligands to achieve modification of the natural tropism. Genetically modified HSVs have been thoroughly tested in humans. New generation recombinants retargeted to cancer-specific heterologous receptors have been generated and are presently evaluated in pre-clinical settings. They will be reviewed along with the molecular bases of can... Herpes journals http://www.medworm.com/rss/comments.php?id=5021771 Thu, 07 Jul 2011 23:00:00 +0100 5021771 http://www.medworm.com/index.php?rid=5021770&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21740359%26dopt%3DAbstract Authors: Kaur B, Chiocca EA, Cripe TP Oncolytic virotherapy with mutants derived from Herpes simplex virus (HSV) type 1 exhibit significant antitumor effects in preclinical models. Several mutants have now been tested in clinical trials for a variety of cancer types, and all have been found to be safe. While there have been hints of antitumor efficacy with prolonged survival in some cases compared with historical controls, dramatic responses have been elusive. We review the clinical experience Publish: 1 June 2011ed to date and discuss some of the biologic factors that may be limiting for virus infection and spread, as well as new strategies currently under development to enhance antitumor efficacy. PMID: 21740359 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5021770 Thu, 07 Jul 2011 23:00:00 +0100 5021770 http://www.medworm.com/index.php?rid=5021769&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21740360%26dopt%3DAbstract Authors: Wong J, Lee C, Zhang K, Rennie PS, Jia W Herpes simplex virus (HSV) is a well-known vector that is often used for gene therapy to treat cancers. The most attractive feature of HSV is its ability to destroy tumors through a distinctive oncolytic mechanism where the virus can destroy cancer cells via cell lysis, a killing function that no anti-cancer drugs can mimic. Importantly, HSV is a safe and effective virus that can be easily manipulated to preferentially replicate in tumor cells. In the last 20 years of re-engineering efforts, a number of HSV designs, including the classical G207, have been focused on deleting viral genes in order to render the virus tumor specific. Although such designs can successfully destroy tumor xenografts in animal models, with minimal impact on no... Herpes journals http://www.medworm.com/rss/comments.php?id=5021769 Thu, 07 Jul 2011 23:00:00 +0100 5021769 http://www.medworm.com/index.php?rid=5021768&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21740363%26dopt%3DAbstract Authors: Borrego-Diaz E, Mathew R, Hawkinson D, Esfandyari T, Liu Z, Lee PW, Farassati F Viruses function in close harmony with the signaling machinery of their host. Upon exposure to the cell, a battery of viral products become engaged in boosting friendly signaling elements of the host or suppressing harmful ones. The efficiency of viral replication is indeed the biological outcome of this interaction between cellular and host signaling molecules. Oncolytic viruses, natural or man-made, follow the same set of rules of engagement. Pro-oncogenic cell signaling machinery, therefore, is undoubtedly the most important area influencing the development of the next generation of effective, specific and rationally designed oncolytic viruses. Ras signaling, with its central role in what is kno... Herpes journals http://www.medworm.com/rss/comments.php?id=5021768 Thu, 07 Jul 2011 23:00:00 +0100 5021768 http://www.medworm.com/index.php?rid=5021767&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21740364%26dopt%3DAbstract Authors: Donnelly OG, Errington-Mais F, Prestwich R, Harrington K, Pandha H, Vile R, Melcher AA There has been interest in using viruses to treat cancer for over a century. Recent clinical efforts, driven on by significant preclinical advances, have focussed on the safety of using replication-competent viruses. Recently Publish: 1 June 2011ed clinical trials of six oncolytic viruses (adenovirus, reovirus, measles, herpes simplex, Newcastle disease virus and vaccinia) have added to the accumulating data that endorse oncolytic viruses as a safe and well tolerated treatment approach. Conclusive evidence of efficacy remains to be demonstrated, but randomised clinical trials are now underway. PMID: 21740364 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5021767 Thu, 07 Jul 2011 23:00:00 +0100 5021767 http://www.medworm.com/index.php?rid=5021763&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21742810%26dopt%3DAbstract Authors: Lagnese M, Daar ES, Christenson P, Rieg G Herpes simplex virus type 2 (HSV-2) HIV co-infection is common and associated with increased risk of HIV transmission. HSV-2 seroprevalence was assessed on stored samples from baseline and one year follow-up from 81 patients identified with acute HIV infection and 81 age-matched chronically infected men. HSV-2 seroprevalence at baseline was lower for those with acute rather than chronic HIV-infection, 51.9 versus 71.6% (P = 0.01); relative risk 0.72 (95% confidence interval [CI] 0.57-0.92). Since HSV-2 seroprevalence is lower in those newly HIV-infected, the diagnosis of early HIV infection may allow for counselling to reduce subsequent HSV-2 acquisition. PMID: 21742810 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5021763 Thu, 07 Jul 2011 23:00:00 +0100 5021763 http://www.medworm.com/index.php?rid=5021784&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21732959%26dopt%3DAbstract We report a patient with PRP whose biopsies showed both herpes simplex infection and FAD. A complete understanding of the mechanism behind this eruption evolved gradually, aided in great measure by the histopathologic findings. Erdag G, Lockman D, Tromberg J, Cropley T, Patterson JW. A case of pityriasis rubra pilaris with associated focal acantholytic dyskeratosis complicated by Kaposi's varicelliform eruption. PMID: 21732959 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5021784 Wed, 06 Jul 2011 23:00:00 +0100 5021784 http://www.medworm.com/index.php?rid=5021776&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21737679%26dopt%3DAbstract In conclusion the common metabolite M6P is also part of a novel mammalian stress signaling pathway, responding to viral stress by depleting host LLOs required for N-glycosylation of virus-associated polypeptides. Apparently conserved throughout evolution, LLO destruction may be a response to a variety of environmental stresses. PMID: 21737679 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5021776 Wed, 06 Jul 2011 23:00:00 +0100 5021776 http://www.medworm.com/index.php?rid=5021783&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21733985%26dopt%3DAbstract Authors: Wang XY, He ZC, Song LY, Spencer S, Yang LX, Peng F, Liu GM, Hu MH, Li HB, Wu XM, Zeng S, Hilgenfeld R, Stöckigt J, Zhao Y, Qian JF The organic extract of Periplaneta americana L. (Dictyoptera; Blattidae) has been traditionally used in southwestern China as an alternative medicine against disorders such as hepatitis, trauma, gastric ulcers, burns, and heart disease.The present study describes bioassay-guided purification and chemotherapeutic evaluation of the 60% ethanolic fraction of P americana organic extracts (PAE60). The most effective cytotoxic fraction was determined by way of repeated in vitro screenings against 12 distinct cultured human carcinoma cell lines: Eca 109, BGC823, HO8910, LS174T, CNE, HeLa, K562, PC-3, A549, BEL 7404, HL-60, and KB, followed by in vivo an... Herpes journals http://www.medworm.com/rss/comments.php?id=5021783 Tue, 05 Jul 2011 23:00:00 +0100 5021783 http://www.medworm.com/index.php?rid=5021782&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21734040%26dopt%3DAbstract Authors: Han J, Chadha P, Meckes D, Baird N, Wills JW The UL11 tegument protein of herpes simplex virus (HSV) plays a critical role in the secondary envelopment; however, the mechanistic details remain elusive. Here, we report a new function of UL11 in the budding process in which it directs efficient acquisition of glycoprotein E (gE) via a direct interaction. In vitro binding assays showed that the interaction required only the first 28, membrane-proximal residues of the cytoplasmic tail (CT) of gE, and the C-terminal 26 residues of UL11. A second, weaker binding site was also found in the N-terminal half of UL11. The significance of the gE-UL11 interaction was subsequently investigated with viral deletion mutants. In the absence of the gE tail, virion packaging of UL11, but not othe... Herpes journals http://www.medworm.com/rss/comments.php?id=5021782 Tue, 05 Jul 2011 23:00:00 +0100 5021782 http://www.medworm.com/index.php?rid=5021781&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21734043%26dopt%3DAbstract Authors: Kalamvoki M, Roizman B Studies published elsewhere have shown that the herpes simplex virus regulatory protein ICP0 interacts with BMAL1, a partner and regulator of circadian histone acetyl transferase CLOCK, that both proteins localize at ND10 bodies and are stabilized by viral proteins, that enzymatically active CLOCK partially complements ΔICP0 mutants, and that silencing of CLOCK suppresses the expression of viral genes. Here we report that CLOCK is a component of the trancriptional complex that includes TFIID, ICP4, ICP27 and ICP22. The results suggest that the CLOCK histone acetyl transferase is a component of the viral transcriptional machinery throughout the replicative cycle of the virus and that ICP27 and ICP22 initiate their involvement in viral genes expression as... Herpes journals http://www.medworm.com/rss/comments.php?id=5021781 Tue, 05 Jul 2011 23:00:00 +0100 5021781 http://www.medworm.com/index.php?rid=5021780&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21734044%26dopt%3DAbstract Authors: Yeh PC, Han J, Chadha P, Meckes DG, Ward MD, Semmes OJ, Wills JW The UL16 tegument protein of herpes simplex virus (HSV) is conserved throughout all the herpesvirus families. Previous studies have shown that binding of HSV to heparan sulfate molecules on the host cell triggers the release of UL16 from the capsid, but the mechanism by which the signal is sent from the virion surface into the tegument is unknown. Here, we report that a GST chimera bearing the cytoplasmic tail of viral glycoprotein E is capable of binding to UL16 in lysates of eukaryotic cells or purified from bacteria. Moreover, mass spectrometry studies of native-UL16 complexes purified from infected cells also revealed the presence of gE. Proof that UL16-gE can interact within cells required the fortuitous dis... Herpes journals http://www.medworm.com/rss/comments.php?id=5021780 Tue, 05 Jul 2011 23:00:00 +0100 5021780 http://www.medworm.com/index.php?rid=5021779&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21734045%26dopt%3DAbstract Authors: Kato A, Liu Z, Minowa A, Imai T, Tanaka M, Sugimoto K, Nishiyama Y, Arii J, Kawaguchi Y Us3 is a serine-threonine protein kinase encoded by herpes simplex virus 1 (HSV-1). We have identified UL47, a major virion protein, as a novel physiological substrate of Us3. In vitro kinase assays and systematic analysis of mutations at putative Us3 phosphorylation sites near the nuclear localization signal of UL47 showed that serine at residue 77 (Ser-77) was required for Us3 phosphorylation of UL47. Substitution of UL47 Ser-77 by alanine produced aberrant accumulation of UL47 at the nuclear rim and impaired nuclear localization of UL47 in a significant fraction of infected cells. The same defect in UL47 localization was produced by an amino acid substitution in Us3 that inactivated its ... Herpes journals http://www.medworm.com/rss/comments.php?id=5021779 Tue, 05 Jul 2011 23:00:00 +0100 5021779 http://www.medworm.com/index.php?rid=5021778&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21734066%26dopt%3DAbstract Authors: Murugin VV, Zuikova IN, Murugina NE, Shulzhenko AE, Pinegin BV, Pashenkov MV NK cells lyse virally infected cells by degranulation; however, alterations of NK cell degranulation in persistent viral infections have not been directly studied. Earlier reports have documented a decrease in NK activity in patients with frequently recurring herpes (FRH). We corroborate these findings by showing that degranulation responses of blood NK cells from patients with FRH, both during relapse and during remission, are significantly lower than those in healthy donors. The impaired degranulation was probably not caused by defective target cell recognition, since it was observed upon stimulation both with K562 cells and with a receptor-independent stimulus (phorbol 12-myristate 13-acetate plus ... Herpes journals http://www.medworm.com/rss/comments.php?id=5021778 Tue, 05 Jul 2011 23:00:00 +0100 5021778 http://www.medworm.com/index.php?rid=5021785&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21732160%26dopt%3DAbstract We report the sixth case of a herpes zoster-associated reactive perforating collagenosis and discuss the current literature. PMID: 21732160 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5021785 Sat, 02 Jul 2011 23:00:00 +0100 5021785 http://www.medworm.com/index.php?rid=5021790&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21725713%26dopt%3DAbstract In conclusion, the results of this study show that antibodies to WNV in people do not seem to be associated with schizophrenia. However, detecting antibodies to WNV in schizophrenic patients suggests that WNV infection should be considered in endemic areas as it may play role in psychiatric diseases. PMID: 21725713 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5021790 Fri, 01 Jul 2011 23:00:00 +0100 5021790 http://www.medworm.com/index.php?rid=5021810&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21718951%26dopt%3DAbstract Authors: Chen L, Guo G, Liu T, Guo L, Zhu R Herpes simplex virus thymidine kinase (HSV-TK) gene/ganciclovir (GCV) system has been widely used as a traditional gene therapy modality, and the sodium/iodide symporter gene (NIS) has been found to be a novel therapeutic gene. Since the therapeutic effects of radioiodine therapy or prodrug chemotherapy on cancers following NIS or HSV-TK gene transfer need to be enhanced, this study was designed to investigate the feasibility of radiochemotherapy for hepatocarcinoma via coexpression of NIS gene and HSV-TK gene. PMID: 21718951 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5021810 Thu, 30 Jun 2011 23:00:00 +0100 5021810 http://www.medworm.com/index.php?rid=5021809&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21719623%26dopt%3DAbstract Authors: Enzler MJ, Berbari E, Osmon DR Antimicrobial prophylaxis is commonly used by clinicians for the prevention of numerous infectious diseases, including herpes simplex infection, rheumatic fever, recurrent cellulitis, meningococcal disease, recurrent uncomplicated urinary tract infections in women, spontaneous bacterial peritonitis in patients with cirrhosis, influenza, infective endocarditis, pertussis, and acute necrotizing pancreatitis, as well as infections associated with open fractures, recent prosthetic joint placement, and bite wounds. Perioperative antimicrobial prophylaxis is recommended for various surgical procedures to prevent surgical site infections. Optimal antimicrobial agents for prophylaxis should be bactericidal, nontoxic, inexpensive, and active against the t... Herpes journals http://www.medworm.com/rss/comments.php?id=5021809 Thu, 30 Jun 2011 23:00:00 +0100 5021809 http://www.medworm.com/index.php?rid=5021808&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21720806%26dopt%3DAbstract Authors: Kofman A, Marcinkiewicz L, Dupart E, Lyshchev A, Martynov B, Ryndin A, Kotelevskaya E, Brown J, Schiff D, Abounader R While some avian retroviruses have been shown to induce gliomas in animal models, human herpesviruses, specifically, the most extensively studied cytomegalovirus, and the much less studied roseolovirus HHV-6, and Herpes simplex viruses 1 and 2, currently attract more and more attention as possible contributing or initiating factors in the development of human brain tumors. The aim of this review is to summarize and highlight the most provoking findings indicating a potential causative link between brain tumors, specifically malignant gliomas, and viruses in the context of the concepts of viral oncomodulation and the tumor stem cell origin. PMID: 21720806 [P... Herpes journals http://www.medworm.com/rss/comments.php?id=5021808 Thu, 30 Jun 2011 23:00:00 +0100 5021808 http://www.medworm.com/index.php?rid=5021807&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21721930%26dopt%3DAbstract The objective of the present study was to develop a sensitive enzyme-linked immunosorbent assay (ELISA) protocol for herpes simplex virus (HSV) antigen detection by assessing the usefulness of hyperimmune sera isolated from HSV-seropositive patients. A total of 52 cerebrospinal fluid (CSF) and 62 serum samples of HSE patients and non-HSE persons were analyzed. An in-house ELISA protocol utilizing hyperimmune sera was developed for HSV antigen detection. To improve the specificity of the method, protein A was incorporated into the protocol for ELISA. The sensitivity (70% and 90%) of antigen detection was high in CSF and serum samples, respectively, of confirmed HSE patients. However, lower specificity (52.3% and 42.3%), respectively, was obtained, which was improved by using protein A in th... Herpes journals http://www.medworm.com/rss/comments.php?id=5021807 Thu, 30 Jun 2011 23:00:00 +0100 5021807 http://www.medworm.com/index.php?rid=5021792&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21724462%26dopt%3DAbstract Authors: Coiffier B, Osmanov EA, Hong X, Scheliga A, Mayer J, Offner F, Rule S, Teixeira A, Walewski J, de Vos S, Crump M, Shpilberg O, Esseltine DL, Zhu E, Enny C, Theocharous P, van de Velde H, Elsayed YA, Zinzani PL, BACKGROUND: Bortezomib and rituximab have shown additive activity in preclinical models of lymphoma, and have been shown to be active and generally well tolerated in a randomised phase 2 study in patients with follicular and marginal zone lymphoma. We compared the efficacy and safety of rituximab alone or combined with bortezomib in patients with relapsed or refractory follicular lymphoma in a phase 3 setting. METHODS: In this multicentre phase 3 trial, rituximab-naive or rituximab-sensitive patients aged 18 years or older with relapsed grade 1 or 2 follicular lymphoma... Herpes journals http://www.medworm.com/rss/comments.php?id=5021792 Thu, 30 Jun 2011 23:00:00 +0100 5021792 http://www.medworm.com/index.php?rid=5021791&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21725588%26dopt%3DAbstract Authors: Ikeda K, Tsujimoto K, Uozaki M, Nishide M, Suzuki Y, Koyama AH, Yamasaki H Hot water extracts of coffee grinds and commercial instant coffee solutions have been shown to exhibit marked antiviral and virucidal activities against herpes simplex virus type 1 (HSV-1). Specifically, it has been shown that caffeine and N-methyl-pyridinium formate inhibit the multiplication of HSV-1 in HEp-2 cells. The present study examined the virological properties and the antiviral activity of caffeic acid against HSV-1. Caffeic acid inhibited the multiplication of HSV-1 in vitro, while chlorogenic acid, a caffeic acid ester with quinic acid, did not. These reagents did not have a direct virucidal effect. The one-step growth curve of HSV-1 showed that the addition of caffeic acid at 8 h post i... Herpes journals http://www.medworm.com/rss/comments.php?id=5021791 Thu, 30 Jun 2011 23:00:00 +0100 5021791 http://www.medworm.com/index.php?rid=5021788&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21729956%26dopt%3DAbstract Authors: Malacova E, Butler T, Richters J, Yap L, Grant L, Richards A, Smith AM, Donovan B The World Health Organization (WHO) has identified a failure to provide education for vulnerable populations such as prisoners as a contributing factor to the epidemic of sexually transmissible infections (STIs). Despite this recognition, little is known about prisoners' level of knowledge of STIs compared with the general population. Using computer-assisted telephone interviews, we compared a representative sample of 2289 Australian prisoners, aged 18-59 years from New South Wales and Queensland prisons with a representative community sample of 3536 participants from these two states. Prisoners had significantly better knowledge than the general community of chlamydia-related questions, while kn... Herpes journals http://www.medworm.com/rss/comments.php?id=5021788 Thu, 30 Jun 2011 23:00:00 +0100 5021788 http://www.medworm.com/index.php?rid=5021787&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21729957%26dopt%3DAbstract Authors: Molina M, Romaguera RA, Valentine J, Tao G To examine the seroprevalence of herpes simplex virus type 2 (HSV-2) among Hispanics in the USA, we used the cross-sectional, nationally representative National Health and Nutrition Examination Survey to compare the seroprevalence of HSV-2 between Hispanic persons of Mexican heritage and non-Mexican heritage aged 14-44 years, from survey years 2007-2008. The overall HSV-2 seroprevalence among Hispanics aged 14-44 years was 17.5% (95% confidence interval [CI], 15.2, 20.1) in the USA. HSV-2 seroprevalence was significantly lower among Mexican Americans than among other Hispanics (11.7% vs. 27.8%, P < 0.01). Prevalence of HSV-2 was also significantly associated with gender and age. The significant difference in HSV-2 seroprevalence be... Herpes journals http://www.medworm.com/rss/comments.php?id=5021787 Thu, 30 Jun 2011 23:00:00 +0100 5021787 http://www.medworm.com/index.php?rid=5021777&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21736611%26dopt%3DAbstract Conclusions: Further research is needed to confirm these findings among varied populations, to explore quality of life following HSV screening, and to identify the characteristics that may make particular individuals more susceptible to adverse psychological consequences. PMID: 21736611 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=5021777 Thu, 30 Jun 2011 23:00:00 +0100 5021777 http://www.medworm.com/index.php?rid=5021765&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21741408%26dopt%3DAbstract Authors: Yu D, Wu S, Wang B, Chen Y, Li L A method that uses specific oligonucleotide probes coupled to a specific array of fluorescent microspheres in multi-analyte suspension arrays was employed for the detection of common viruses, such as Herpes virus (HSV), Human papillomavirus (HPV) and Hepatitis B virus (HBV). Sixteen species-specific probes and 9 sets of specific primers were designed based on conserved sequences of these viruses in the GenBank database. Serial symmetric PCR, asymmetric PCR and multiple PCR assays were employed to evaluate the sensitivity, specificity and reproducibility of multi-analyte suspension arrays analyzed on a Luminex-100 analyzer instrument. The symmetric PCR amplification of four types of HSV, four types of HPV and HBV genotypes of B, C and D, combine... Herpes journals http://www.medworm.com/rss/comments.php?id=5021765 Thu, 30 Jun 2011 23:00:00 +0100 5021765 http://www.medworm.com/index.php?rid=4972845&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21670657%26dopt%3DAbstract Authors: Snow M PMID: 21670657 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=4972845 Tue, 28 Jun 2011 10:50:34 +0100 4972845 http://www.medworm.com/index.php?rid=4972841&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21673042%26dopt%3DAbstract Conclusions. STIs may increase HIV-1 replication in the female genital tract via proinflammatory signaling pathways directly and indirectly via their effects on GECs. This increased HIV-1 replication may enhance sexual and vertical HIV transmission. PMID: 21673042 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=4972841 Tue, 28 Jun 2011 10:50:06 +0100 4972841 http://www.medworm.com/index.php?rid=4972835&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21677611%26dopt%3DAbstract Authors: Khaki M, Ghazavi A, Ghasami K, Rafiei M, Payani MA, Ghaznavi-Rad E, Mosayebi G To evaluate the viral antibodies in new Iranian multiple sclerosis (MS) patients. PMID: 21677611 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=4972835 Tue, 28 Jun 2011 10:49:33 +0100 4972835 http://www.medworm.com/index.php?rid=4972834&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21677622%26dopt%3DAbstract Authors: Mousali YM, Sobhi EM, Makkawi SO A 17-year-old female patient, known case of sickle cell anemia was admitted to our hospital with 10 days history of fever, vomiting, and epigastric pain. On examination, her temperature was 38°C. There was a vesicular type of rash below the nipple and over the left chest involving the back. She was diagnosed as herpes zoster and was started on acyclovir with good hydration and analgesia. Three days later, she developed weakness and decreased sensation of the right leg. On the fifth day, examination revealed power of 1/5 on the right leg, and 4/5 on the left leg, there was proximal and distal increased tone and brisk reflexes and up going toe on the right side with sensory level at T4-T6. An MRI of the thoracolumbar spine showed high signal int... Herpes journals http://www.medworm.com/rss/comments.php?id=4972834 Tue, 28 Jun 2011 10:49:27 +0100 4972834 http://www.medworm.com/index.php?rid=4972829&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21679801%26dopt%3DAbstract Authors: Dougherty AL, Rashid RM, Bangert CA PMID: 21679801 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=4972829 Tue, 28 Jun 2011 10:48:31 +0100 4972829 http://www.medworm.com/index.php?rid=4972823&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21682749%26dopt%3DAbstract Authors: Boguniewicz M, Leung DY Atopic dermatitis (AD) is an important chronic or relapsing inflammatory skin disease that often precedes asthma and allergic disorders. New insights into the genetics and pathophysiology of AD point to an important role of structural abnormalities in the epidermis as well as immune dysregulation not only for this skin disease but also for the development of asthma and allergies. Patients with AD have a unique predisposition to colonization or infection by microbial organisms, most notably Staphylococcus aureus and herpes simplex virus. Measures directed at healing and protecting the skin barrier and addressing the immune dysregulation are essential in the treatment of patients with AD, and early intervention may improve outcomes for both the skin disea... Herpes journals http://www.medworm.com/rss/comments.php?id=4972823 Tue, 28 Jun 2011 10:48:08 +0100 4972823 http://www.medworm.com/index.php?rid=4972796&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21704818%26dopt%3DAbstract Authors: Tang SJ, McCrady W, Rawls D PMID: 21704818 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=4972796 Tue, 28 Jun 2011 10:45:17 +0100 4972796 http://www.medworm.com/index.php?rid=4972833&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21678366%26dopt%3DAbstract Authors: Wiysonge CS, Kongnyuy EJ, Shey M, Muula AS, Navti OB, Akl EA, Lo YR Previous systematic reviews found inconsistent effects of male circumcision on HIV acquisition in men who have sex with men (MSM). However, a number of new studies have become available in the three years since the last systematic review. PMID: 21678366 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=4972833 Tue, 28 Jun 2011 10:45:04 +0100 4972833 http://www.medworm.com/index.php?rid=4972832&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21679386%26dopt%3DAbstract Authors: Burris H, Parkhurst J, Adu-Sarkodie Y, Mayaud P Observational epidemiological and biological data indicate clear synergies between Herpes simplex virus type 2 (HSV-2) and HIV, whereby HSV-2 enhances the potential for HIV acquisition or transmission. In 2001, the World Health Organization (WHO) launched a call for research into the possibilities of disrupting this cofactor effect through the use of antiherpetic therapy. A WHO Expert Meeting was convened in 2008 to review the research results. The results of the trials were mostly inconclusive or showed no impact. However, the WHO syndromic management treatment guidelines were modified to include acyclovir as first line therapy to treat genital ulcer disease on the basis of the high prevalence of HSV-2 in most settings, impact a... Herpes journals http://www.medworm.com/rss/comments.php?id=4972832 Tue, 28 Jun 2011 10:45:04 +0100 4972832 http://www.medworm.com/index.php?rid=4972831&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21679389%26dopt%3DAbstract Authors: Delany-Moretlwe S, Stadler J, Mayaud P, Rees H Communicating the results of randomised controlled trials may present challenges for researchers who have to work with communities and policy-makers to anticipate positive outcomes, while being aware that results may show no effect or harm. PMID: 21679389 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=4972831 Tue, 28 Jun 2011 10:45:04 +0100 4972831 http://www.medworm.com/index.php?rid=4972811&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21697878%26dopt%3DAbstract Authors: Hu YP, Lin SY, Huang CY, Zulueta MM, Liu JY, Chang W, Hung SC Cell surface carbohydrates play significant roles in a number of biologically important processes. Heparan sulfate, for instance, is a ubiquitously distributed polysulfated polysaccharide that is involved, among other things, in the initial step of herpes simplex virus type 1 (HSV-1) infection. The virus interacts with cell-surface heparan sulfate to facilitate host-cell attachment and entry. 3-O-Sulfonated heparan sulfate has been found to function as an HSV-1 entry receptor. Achieving a complete understanding of these interactions requires the chemical synthesis of such oligosaccharides, but this remains challenging. Here, we present a convenient approach for the synthesis of two irregular 3-O-sulfonated heparan s... Herpes journals http://www.medworm.com/rss/comments.php?id=4972811 Tue, 28 Jun 2011 10:45:04 +0100 4972811 http://www.medworm.com/index.php?rid=4972798&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21703002%26dopt%3DAbstract We report on a 75-year old woman with pneumococcal meningoencephalitis who presented altered level of consciousness, acute focal deficits, convulsive seizures and PLEDs in left hemisphere. The finding of PLEDs on the electroencephalogram is related to focal lesions of heterogeneous origin, which up to date, have not been documented in pneumococcal infections of the central nervous system. Our case highlights the importance of identifying and addressing any modifiable etiologic factors of PLEDs. PMID: 21703002 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=4972798 Fri, 24 Jun 2011 23:00:00 +0100 4972798 http://www.medworm.com/index.php?rid=4972809&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21698489%26dopt%3DAbstract Authors: Langer MF, Surke C, Lötters E OBJECTIVE: The goal of excision of a subcutaneous abscess in the distal pulp of the fingertip is the fast and complete removal of the infected and devitalized tissue. INDICATIONS: Every acute infection of the fingertip. CONTRAINDICATIONS: Atypical infections, e.g., Herpes, Orf's disease, mycobacterial infections. SURGICAL TECHNIQUE: Excision of the infected area in the fingertip without damaging the digital nerves and their branches. POSTOPERATIVE MANAGEMENT: The wound is left open and is covered with a moist dressing. RESULTS: Early targeted incision brings good functional and cosmetic results. PMID: 21698489 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=4972809 Thu, 23 Jun 2011 23:00:00 +0100 4972809 http://www.medworm.com/index.php?rid=4972808&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21698490%26dopt%3DAbstract Authors: Langer MF, Lötters E, Wieskötter B, Surke C OBJECTIVE: The procedure is selected based on the stage of infection with careful removal of the focal infection in the area of the nail fold. INDICATIONS: All infections of the periungual area. CONTRAINDICATIONS: Herpes infections [1, 12]. All purulent infections of the periungual area should be eliminated. SURGICAL TECHNIQUE: Opening of the abscess, excision of the eponychium, mobilization of the nail barrier away from the nail plate, inzision of the nail barrier at a defined place, necrosectomy, irrigation, and drainage. POSTOPERATIVE MANAGEMENT: Moist dressings and fingerbaths in the first few days. RESULTS: In most cases, the infection heals completely without substantial scar formation. PMID: 21698490 [PubMed - as supplie... Herpes journals http://www.medworm.com/rss/comments.php?id=4972808 Thu, 23 Jun 2011 23:00:00 +0100 4972808 http://www.medworm.com/index.php?rid=4972806&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21699441%26dopt%3DAbstract Authors: Andrei G, Snoeck R Introduction: Varicella-zoster virus (VZV) is the etiological agent of two distinct diseases, varicella (chickenpox) and shingles (herpes zoster). Chickenpox occurs following primary infection, while herpes zoster (usually associated with ageing and immunosuppression) is the consequence of reactivation of the latent virus. Post-herpetic neuralgia is the major complication of shingles. Areas covered: This review will discuss vaccination strategies and the current status of antivirals against VZV. A live attenuated vaccine, Varivax, is available for pediatric varicella while Zostavax was developed to boost VZV-specific cell-mediated immunity in adults older than 60 years and, via this mechanism, to decrease the burden of herpes zoster and pain associated with ... Herpes journals http://www.medworm.com/rss/comments.php?id=4972806 Thu, 23 Jun 2011 23:00:00 +0100 4972806 http://www.medworm.com/index.php?rid=4972803&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21700542%26dopt%3DAbstract Authors: Failla V, Castronovo C, Meex C, Nikkels AF PMID: 21700542 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=4972803 Thu, 23 Jun 2011 23:00:00 +0100 4972803 http://www.medworm.com/index.php?rid=4972802&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21701533%26dopt%3DAbstract Authors: Wood LW, Shillitoe EJ The oncolytic effects of herpes simplex virus-1 (HSV-1) are limited, possibly because of premature death of infected cells by apoptosis, which limits the amount of progeny virus that is produced. It has been proposed that inhibition of apoptosis in infected tumor cells would allow increased viral persistence, replication and therapeutic effect. To test this hypothesis, we infected monocyte chemoattractant factor-7 (MCF-7) and MDA-MB-231 breast cancer cells with HSV-1 strain 17(+) and 17Δγ34.5 in the presence or absence of N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone (zVADfmk), a pan-caspase inhibitor. At low doses of HSV-1 strain 17(+) and 17Δγ34.5, the growth of MCF-7 cells was reduced to 37% or 42%, respectively, of uninfected cells. However, ... Herpes journals http://www.medworm.com/rss/comments.php?id=4972802 Thu, 23 Jun 2011 23:00:00 +0100 4972802 http://www.medworm.com/index.php?rid=4972801&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21701901%26dopt%3DAbstract CONCLUSION: In C57BL/6J mice, MHV68 infection promotes fatty liver formation and hepatic insulin resistance, which can be ameliorated by sirolimus. PMID: 21701901 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=4972801 Thu, 23 Jun 2011 23:00:00 +0100 4972801 http://www.medworm.com/index.php?rid=4972800&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21702916%26dopt%3DAbstract CONCLUSIONS: The main finding of this study is that obstetric events, HIV and other STIs contribute approximately equally to secondary infertility in Rwanda. Scaling up of HIV/STI prevention, increased access to family planning services, improvement of prenatal and obstetric care and reduction of stillbirth and infant mortality rates are all likely to decrease secondary infertility in sub-Saharan Africa. PMID: 21702916 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=4972800 Thu, 23 Jun 2011 23:00:00 +0100 4972800 http://www.medworm.com/index.php?rid=4972799&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21702927%26dopt%3DAbstract CONCLUSION: ZFNs with specificity to HSV-2 genomic DNA that are precursors of novel host-genome expressed HSV-2 gene-therapeutics or vaccines were identified. PMID: 21702927 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=4972799 Thu, 23 Jun 2011 23:00:00 +0100 4972799 http://www.medworm.com/index.php?rid=4972795&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21705099%26dopt%3DAbstract Authors: Hellard E, Fouchet D, Santin-Janin H, Tarin B, Badol V, Coupier C, Leblanc G, Poulet H, Pontier D In natural populations, virus circulation is influenced by host behavior and physiological characteristics. Cat populations exhibit a great variability in social and spatial structure, the existence of different ways of life within a same population may also result in different epidemiological patterns. To test this hypothesis, we used a logistic regression to analyze the risk factors of Feline immunodeficiency virus (FIV), feline herpes virus (FHV), feline calicivirus (FCV), and feline parvovirus (FPV) infection in owned (fed and sheltered) and unowned (neither fed nor sheltered, unsocialized) cats living in a rural environment in the North Eastern part of France. A serological s... Herpes journals http://www.medworm.com/rss/comments.php?id=4972795 Thu, 23 Jun 2011 23:00:00 +0100 4972795 http://www.medworm.com/index.php?rid=4972810&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21698427%26dopt%3DAbstract Authors: Preuß E, Muik A, Weber K, Otte J, von Laer D, Fehse B Suicide gene therapy is a promising concept in oncology. We have recently introduced a novel suicide gene, TK.007, which was shown to excel established herpes simplex virus thymidine kinase (HSVtk) variants when used for donor-lymphocyte modification in adoptive immunotherapy models. Here, the potential of TK.007 in killing cancer cells was studied. Initially, we transduced tumour cell lines derived from different neoplasias (glioblastoma, melanoma, lung cancer, colon cancer) with lentiviral LeGO vectors encoding TK.007 or the splice-corrected (sc)HSVtk together with an eGFP/Neo-marker. Based on direct in vitro comparison, we found that TK.007 facilitates more efficient tumour cell killing at significantly lower ganciclovi... Herpes journals http://www.medworm.com/rss/comments.php?id=4972810 Wed, 22 Jun 2011 23:00:00 +0100 4972810 http://www.medworm.com/index.php?rid=4972817&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21696254%26dopt%3DAbstract Conclusions: Multiple logistic regression showed that age was a significant predictor of both HSV-1 and HSV-2 seropositivity, while female gender was a significant predictor of HSV-2 seropositivity. In pregnant women, obstetric history was not a significant predictor of either HSV-1 or HSV-2 seroprevalence. PMID: 21696254 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=4972817 Tue, 21 Jun 2011 23:00:00 +0100 4972817 http://www.medworm.com/index.php?rid=4972815&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21697348%26dopt%3DAbstract Authors: Cohen M, Braun E, Tsalenchuck Y, Panet A, Steiner I Elucidating the cellular and molecular factors governing HSV-1 neurotropism is a prerequisite for understanding HSV-1 encephalitis and for targeting HSV-1-derived vectors for gene transfer to the brain. Earlier we have described an ex-vivo system of mouse brain slices and demonstrated a selective and unique infection pattern, mostly around the ventricles. Here we examined tissue factors controlling HSV-1 infection of brain slices. We demonstrated that heparan sulphate, while an important factor, does not determine the infection pattern. Hyaluronic acid, but not collagen, appears to enhance HSV-1 brain infection. To investigate whether tissue distribution of viral receptors determines the infection pattern, we examined transcr... Herpes journals http://www.medworm.com/rss/comments.php?id=4972815 Tue, 21 Jun 2011 23:00:00 +0100 4972815 http://www.medworm.com/index.php?rid=4972814&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21697465%26dopt%3DAbstract Authors: Dufour F, Bertrand L, Pearson A, Grandvaux N, Langelier Y We recently provided evidence that the ribonucleotide reductase R1 subunits of herpes simplex virus types 1 and 2 (HSV-1 and -2) protect cells against tumor necrosis factor alpha- and Fas ligand-induced apoptosis by interacting with caspase-8. Double-stranded RNA (dsRNA) is a viral intermediate known to initiate innate antiviral responses. Poly(I:C), a synthetic analogue of viral dsRNA, rapidly triggers caspase-8 activation and apoptosis in HeLa cells. Here, we report that HeLa cells after HSV-1 and HSV-2 infection were quickly protected from apoptosis caused by either extracellular poly(I:C) combined with cycloheximide or transfected poly(I:C). Cells infected with the HSV-1 R1 deletion mutant ICP6Δ were killed by poly... Herpes journals http://www.medworm.com/rss/comments.php?id=4972814 Tue, 21 Jun 2011 23:00:00 +0100 4972814 http://www.medworm.com/index.php?rid=4972813&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21697480%26dopt%3DAbstract In this study we show that in mature HSV-1 virions, capsid proteins VP5, VP23, VP19C, UL17 and UL25 participate in covalent cross-links and that these are susceptible to DTT. In addition several tegument proteins were found in high molecular weight complexes including VP22, UL36 and UL37. Cross-linked capsid complexes can be detected in virions isolated in the presence and absence of N-ethylmaleimide (NEM), a chemical that reacts irreversibly with free cysteines to block disulfide formation. Intracellular capsids isolated in the absence of NEM contain disulfide cross-linked species; however, intracellular capsids isolated from cells pretreated with NEM did not. Thus, the free cysteines in intracellular capsids appear to be positioned such that disulfide bond formation can occur readily if ... Herpes journals http://www.medworm.com/rss/comments.php?id=4972813 Tue, 21 Jun 2011 23:00:00 +0100 4972813 http://www.medworm.com/index.php?rid=4972812&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21697531%26dopt%3DAbstract Authors: Sutendra G, Dromparis P, Wright P, Bonnet S, Haromy A, Hao Z, McMurtry MS, Michalak M, Vance JE, Sessa WC, Michelakis ED Pulmonary arterial hypertension (PAH) is caused by excessive proliferation of vascular cells, which occlude the lumen of pulmonary arteries (PAs) and lead to right ventricular failure. The cause of the vascular remodeling in PAH remains unknown, and the prognosis of PAH remains poor. Abnormal mitochondria in PAH PA smooth muscle cells (SMCs) suppress mitochondria-dependent apoptosis and contribute to the vascular remodeling. We hypothesized that early endoplasmic reticulum (ER) stress, which is associated with clinical triggers of PAH including hypoxia, bone morphogenetic protein receptor II mutations, and HIV/herpes simplex virus infections, explains the mi... Herpes journals http://www.medworm.com/rss/comments.php?id=4972812 Tue, 21 Jun 2011 23:00:00 +0100 4972812 http://www.medworm.com/index.php?rid=4972807&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21698567%26dopt%3DAbstract Authors: Czell D, Mehmeti N, Sartoretti S, Rodic B, Ballmer PE Nowadays with a lot of diagnostic facilities it is also difficult to find the right diagnose of herpes encephalitis. The aim of this case report was to give an overview about strategies of diagnostic and therapy of the herpes encephalitis. PMID: 21698567 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=4972807 Tue, 21 Jun 2011 23:00:00 +0100 4972807 http://www.medworm.com/index.php?rid=4972797&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21703716%26dopt%3DAbstract CONCLUSION: When associated with serum IgE levels 10 times the age-appropriate level, a neonatal papulopustular rash progressing to a chronic impetiginized eczematous dermatitis that differs from classic atopic dermatitis is highly suggestive of AD-HIES. Early recognition is important for initiation of prophylactic antistaphylococcal and antifungal treatment. PMID: 21703716 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=4972797 Tue, 21 Jun 2011 23:00:00 +0100 4972797 http://www.medworm.com/index.php?rid=4972805&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21700397%26dopt%3DAbstract Authors: Mori I PMID: 21700397 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=4972805 Mon, 20 Jun 2011 23:00:00 +0100 4972805 http://www.medworm.com/index.php?rid=4972804&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21700476%26dopt%3DAbstract Authors: Choi BK, Kim YH, Choi JH, Kim CH, Kim KS, Sung YC, Lee YM, Moffett JR, Kwon BS 4-1BB (CD137) is a powerful T-cell costimulatory molecule in the treatment of virus infections and tumors, but recent studies have also uncovered regulatory functions of 4-1BB signaling. Since 4-1BB triggering suppresses autoimmunity by accumulating indoleamine 2,3-dioxygenase (IDO) in dendritic cells (DCs) in an interferon (IFN)-γ-dependent manner, we asked whether similar molecular and cellular changes were induced by 4-1BB triggering in virus-infected mice. 4-1BB triggering increased IFN-γ and IDO, and suppressed CD4(+) T cells, in C57BL/6 mice infected with the type 1 KOS strain of Herpes simplex virus (HSV-1), as it does in an autoimmune disease model. Detailed analysis of the CD4(+) T suppre... Herpes journals http://www.medworm.com/rss/comments.php?id=4972804 Mon, 20 Jun 2011 23:00:00 +0100 4972804 http://www.medworm.com/index.php?rid=4972821&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21689024%26dopt%3DAbstract Conclusions: Education efforts in secondary school health programs and during gynecologic examinations can decrease confusion about STI testing. PMID: 21689024 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=4972821 Sun, 19 Jun 2011 23:00:00 +0100 4972821 http://www.medworm.com/index.php?rid=4972820&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21690298%26dopt%3DAbstract Authors: Lin WJ, Zheng X, Lin CC, Tsao J, Zhu X, Cody JJ, Coleman JM, Gherzi R, Luo M, Townes TM, Parker JN, Chen CY Inherently unstable mRNAs contain the AU-rich elements (AREs) in the 3' untranslated regions. Expression of ARE-containing type I interferon transcripts is robustly induced upon viral infection and rapidly shut off thereafter. Their transient accumulation is partly mediated through post-transcriptional regulation. Here we show that mouse embryonic fibroblasts derived from knockout mice deficient in KH-type Splicing Regulatory Protein (KSRP), an RNA-binding protein required for ARE-mediated mRNA decay, produce higher levels of Ifna and Ifnb mRNAs in response to viral infection as a result of decreased mRNA decay. Functional analysis shows that KSRP is required for the dec... Herpes journals http://www.medworm.com/rss/comments.php?id=4972820 Sun, 19 Jun 2011 23:00:00 +0100 4972820 http://www.medworm.com/index.php?rid=4972816&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21696875%26dopt%3DAbstract Authors: Moreno-Martínez FJ, Goñi-Imízcoz M, Spitznagel MB Category specific semantic impairment (e.g. living versus nonliving things) has been reported in association with various pathologies, including herpes simplex encephalitis and semantic dementia. However, evidence is inconsistent regarding whether this effect exists in diseases progressively impacting diverse cortical regions, such as Alzheimer's disease (AD). Ceiling effects producing non-Gaussian distributions and poor control for confounds such as nuisance variables (e.g. familiarity) may contribute to this discrepancy. Fourteen AD patients were longitudinally studied examining category effects on three semantic tasks (picture naming, naming to description and word to picture matching) matched across domain on all known n... Herpes journals http://www.medworm.com/rss/comments.php?id=4972816 Sun, 19 Jun 2011 23:00:00 +0100 4972816 http://www.medworm.com/index.php?rid=4972848&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21666542%26dopt%3DAbstract Authors: Ludema C, Cole SR, Poole C, Chu H, Eron JJ : To summarize the randomized evidence regarding the association between acyclovir use and HIV-1 replication as measured by plasma HIV-1 RNA viral load among individuals coinfected with herpes simplex virus (HSV)-2. PMID: 21666542 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=4972848 Sat, 18 Jun 2011 23:00:00 +0100 4972848 http://www.medworm.com/index.php?rid=4972822&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21685219%26dopt%3DAbstract Conclusions The incidence of HSV-induced serious neurological disease in the UK was estimated at 1 in 64 000/year in younger children and 1 in 230 000 in older children. HSV CNS infection has clinical effects ranging from frank encephalitis to severe illness with fever and convulsions to milder disease lacking encephalopathy. PMID: 21685219 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=4972822 Thu, 16 Jun 2011 23:00:00 +0100 4972822 http://www.medworm.com/index.php?rid=4972830&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21679419%26dopt%3DAbstract CONCLUSION: Our study provides important baseline estimates for HZ-related disease burden in Germany. HZ poses a considerable burden on the health care system in Germany both in terms of outpatient and inpatient services. Follow-up assessments of HZ disease burden are needed to monitor the impact of VZV-vaccinations in Germany. PMID: 21679419 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=4972830 Wed, 15 Jun 2011 23:00:00 +0100 4972830 http://www.medworm.com/index.php?rid=4972828&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21680502%26dopt%3DAbstract Authors: Zenner HL, Yoshimura SI, Barr FA, Crump CM Assembly of herpes simplex virus 1 (HSV-1) occurs in the cytoplasm, where the capsid and tegument bud into host cell membranes. It is at this point that the viral glycoproteins are incorporated into the virion, as they are located at the assembly site. We investigated the role of the Rab GTPases in coordinating the assembly process by overexpressing 37 human Rab GTPase activating proteins (GAPs) and assessing infectious titres. Rab GTPases are key cellular regulators of membrane trafficking events that, by their membrane association and binding of effector proteins, ensure the appropriate fusion of membranes. We identified that TBC1D20 and RN-tre and their partner Rabs, Rab1a/b and Rab43 respectively, are important for virion assembly... Herpes journals http://www.medworm.com/rss/comments.php?id=4972828 Tue, 14 Jun 2011 23:00:00 +0100 4972828 http://www.medworm.com/index.php?rid=4972842&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21672032%26dopt%3DAbstract Authors: Feldhahn M, Menzel M, Weide B, Bauer P, Meckbach D, Garbe C, Kohlbacher O, Bauer J   Several viruses are known to cause cancer, such as human herpes virus 8 in Kaposi sarcoma and human papilloma viruses in cervical cancer. Recently, Merkel cell polyoma virus (MCPyV) has been described in 80% of Merkel cell carcinomas (MCC). Similarly to MCC and Kaposi sarcoma, melanoma incidence is increased in immunosuppressed patients. We asked whether infection by known or yet unknown viruses may play a role in melanoma development as well. To detect viral sequences expressed in melanoma cells, we analysed three melanoma metastases by whole-transcriptome sequencing and digital transcriptome subtraction. None of the samples investigated harboured viral sequences. In contrast, artificial vi... Herpes journals http://www.medworm.com/rss/comments.php?id=4972842 Mon, 13 Jun 2011 23:00:00 +0100 4972842 http://www.medworm.com/index.php?rid=4972840&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21673184%26dopt%3DAbstract Conclusions Genital herpes in children under 11 years is rare. Almost a third of children diagnosed with genital herpes did not have appropriate virological investigation and few were screened for other STIs. Around a quarter of cases were referred to child protection agencies for further investigation, which limits any inferences in this study about mode of transmission in children. Sexual abuse guidance should emphasise the need for thorough assessment and investigation in cases of genital herpes in children. PMID: 21673184 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=4972840 Mon, 13 Jun 2011 23:00:00 +0100 4972840 http://www.medworm.com/index.php?rid=4972839&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21673661%26dopt%3DAbstract Authors: Yao X, Yoshioka Y, Morishige T, Eto Y, Narimatsu S, Kawai Y, Mizuguchi H, Gao JQ, Mukai Y, Okada N, Nakagawa S Previously, we generated a cancer-specific gene therapy system using adenovirus vectors (Adv) conjugated to polyethylene glycol (Adv-PEG). Here, we developed a novel Adv that targets both tumor tissues and tumor vasculatures after systemic administration by conjugating CGKRK tumor vasculature homing peptide to the end of a 20-kDa PEG chain (Adv-PEG(CGKRK)). In a primary tumor model, systemic administration of Adv-PEG(CGKRK) resulted in ~500- and 100-fold higher transgene expression in tumor than that of unmodified Adv and Adv-PEG, respectively. In contrast, the transgene expression of Adv-PEG(CGKRK) in liver was about 400-fold lower than that of unmodified Adv, and wa... Herpes journals http://www.medworm.com/rss/comments.php?id=4972839 Mon, 13 Jun 2011 23:00:00 +0100 4972839 http://www.medworm.com/index.php?rid=4972836&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21677575%26dopt%3DAbstract CONCLUSIONS: SNALE may masquerade as glioma. Pathologic changes in our case of SNALE are distinctive. Spontaneous resolution of a focal SNALE lesion may potentially occur without immune therapy. PMID: 21677575 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=4972836 Mon, 13 Jun 2011 23:00:00 +0100 4972836 http://www.medworm.com/index.php?rid=4972818&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21693182%26dopt%3DAbstract We report results from a randomized, double-blind, placebo-controlled, crossover trial of acyclovir in 19 women for whom personality was assessed at baseline and daily assessments of genital lesions, stress, anxiety, and depression levels were collected for 22weeks. In addition, daily swabs of the genital mucosa were collected to assess HSV-2 viral reactivation. We found that daily stress predicted genital lesion frequency, and that daily stress, anxiety, and depression predicted genital lesion onset approximately 5days before onset. Anxiety was also associated with genital lesions 3days after onset. Distress and viral reactivation were not associated; and no personality traits were associated with any of the outcomes. These results support the hypothesis that psychological distress is bot... Herpes journals http://www.medworm.com/rss/comments.php?id=4972818 Sun, 12 Jun 2011 23:00:00 +0100 4972818 http://www.medworm.com/index.php?rid=4972847&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21667075%26dopt%3DAbstract Authors: Shirvani E, Lotfi M, Kamalzadeh M, Noaman V, Bahriari M, Morovati H, Hatami A Respiratory diseases in calves are responsible for major economic losses in both beef and dairy production. Several viruses, such as bovine respiratory syncytial virus (BRSV), bovine herpes virus-1 (BoHV-1), bovine parainfluenza virus-3 (BPI-3V), bovine viral diarrhea virus (BVDV), and bovine adenoviruses (BAV), are detected in most clinical cases with respiratory signs. The aim of this study is to define seroprevalences of five major viral causes of bovine respiratory infections in cattle in central region of Iran (Esfahan province). The population targeted was 642 dairy cows (Holstein-Friesian) from 25 farms. Samples of blood serum from female cattle were examined. Sera were tested by commercial EL... Herpes journals http://www.medworm.com/rss/comments.php?id=4972847 Fri, 10 Jun 2011 23:00:00 +0100 4972847 http://www.medworm.com/index.php?rid=4972851&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21663640%26dopt%3DAbstract CONCLUSION: These results indicate that novel oncolytic HSV-1 vectors can be produced with the genetic background of the oncolytic HSV-1 HF, and that RH2 is deficient in gamma 34.5 genes and shows extensive cytopathic effects in oral SCC cells. RH2 may be useful in oncolytic virotherapy for oral SCC. PMID: 21663640 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=4972851 Thu, 09 Jun 2011 23:00:00 +0100 4972851 http://www.medworm.com/index.php?rid=4972850&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21665410%26dopt%3DAbstract Authors: Bonacchi M, Lascio GD, Harmelin G, Pasquini A, Peris A, Sani G PMID: 21665410 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=4972850 Thu, 09 Jun 2011 23:00:00 +0100 4972850 http://www.medworm.com/index.php?rid=4972849&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21665532%26dopt%3DAbstract Authors: Moses SE, Osborne W, Valappil M, Collin M, Lee D, Waugh S, Jackson G, Parry CM, Crowley B PMID: 21665532 [PubMed - as supplied by publisher] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=4972849 Thu, 09 Jun 2011 23:00:00 +0100 4972849 http://www.medworm.com/index.php?rid=4972846&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21668314%26dopt%3DAbstract This article summarizes the substantial progress made in this field during the past two decades and gives future perspectives about challenges that need to be addressed before antigen-specific immunotherapy against herpes family viruses can be implemented in general clinical practice. PMID: 21668314 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=4972846 Tue, 31 May 2011 23:00:00 +0100 4972846 http://www.medworm.com/index.php?rid=4972844&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21670919%26dopt%3DAbstract Authors: Ziyaeyan M, Alborzi A, Borhani Haghighi A, Jamalidoust M, Moeini M, Pourabbas B Diagnosis of herpes simplex encephalitis (HSE) is based on the detection of herpes simplex virus (HSV) DNA in patients' CSF samples. HSV DNA quantitation has the potential for estimating the effects of antiviral therapy. The aim of this study was to diagnose HSV DNA in HSE suspected patients and the quantitative analysis of its genome using real-time PCR to assess the value of the viral load in the course of antiviral treatment. The CSF samples were collected from 236 consecutive HSE suspected patients from November 2004 to May 2008. Upon DNA extraction, the samples were analyzed by Real-Time PCR assay. A set of primers amplified a common sequence of HSV glycoprotein B gene. The copy numbers of unk... Herpes journals http://www.medworm.com/rss/comments.php?id=4972844 Tue, 31 May 2011 23:00:00 +0100 4972844 http://www.medworm.com/index.php?rid=4972843&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21670930%26dopt%3DAbstract Authors: Marques NM, Margalho R, Melo MJ, Cunha JG, Meliço-Silvestre AA A cross-sectional study was conducted in 151 (71.6%) of 211 male inmates of a regional Portuguese prison in order to establish the seroprevalence for viral hepatitis (HAV, HBV, HCV), human immunodeficiency virus (HIV), syphilis and herpes simplex virus (HSV-1 and HSV-2) and to analyze some psychosocial and criminal characteristics. Mean age was 34 years. Anti-HAV was positive in 69.5% (n = 105) and in 34.4% (n = 52) for anti-HCV. One (0.7%) person had HBsAg and 29 (19.2%) had laboratory markers of past HBV infection. Non-immune inmates for HBV were 40.4% (n = 61). Syphilis was diagnosed in 6.0% (n = 9). The rate of HIV infection was 6.6% (n = 10; all HIV-1). The seropositivity of HSV-2 was 19.9% (n = 30) and of HS... Herpes journals http://www.medworm.com/rss/comments.php?id=4972843 Tue, 31 May 2011 23:00:00 +0100 4972843 http://www.medworm.com/index.php?rid=4972838&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21660747%26dopt%3DAbstract Authors: Poon AN, Li Z, Wang N, Hong Y Female sex workers (FSW) are at greater risk for HIV and STIs. A systematic literature review of HIV and STI prevalence and incidence data for FSW in China was conducted to assess current trends. Studies between 1996 and 2010 detailing seroprevalence or incidence data, other laboratory-based tests, and clinical diagnoses of infections among FSW were reviewed. Select articles from Chinese literature around street-based and drug-abusing FSW were also reviewed. Results revealed high median prevalence for a variety of STIs among FSW: active syphilis range 0.8-12.5% (median = 6.9%), herpes range 29.7-70.8% (median = 56.2%), chlamydia range 3.9-58.6% (median = 25.7%), gonorrhea range 2.0-85.4% (median = 16.4%), and trichomoniasis range 7.1-43.2% (median... Herpes journals http://www.medworm.com/rss/comments.php?id=4972838 Tue, 31 May 2011 23:00:00 +0100 4972838 http://www.medworm.com/index.php?rid=4972837&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21660749%26dopt%3DAbstract In conclusion, HSV-2 is highly prevalent among FSW in Shanghai, with a relatively low prevalence of syphilis. The currently low HIV epidemic in this population provides a window of opportunity to implement tailored HIV/STD prevention and control efforts targeting them, with particular attentions to large numbers of HSV-2-infected FSW and their clients. PMID: 21660749 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=4972837 Tue, 31 May 2011 23:00:00 +0100 4972837 http://www.medworm.com/index.php?rid=4972827&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21680663%26dopt%3DAbstract Authors: Farazmand P, Woolley PD, Kinghorn GR Benign recurrent aseptic meningitis is a rare disorder described by Mollaret in 1944. When initially described, this form of aseptic meningitis had no identifiable infecting agent. New sophisticated diagnostic tools have now identified herpes simplex type 2 virus as the most commonly isolated agent. Antiviral treatment has been used successfully for prophylaxis and treatment. PMID: 21680663 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=4972827 Tue, 31 May 2011 23:00:00 +0100 4972827 http://www.medworm.com/index.php?rid=4972826&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21680668%26dopt%3DAbstract Authors: Roth AM, Dodge BM, Van Der Pol B, Reece M, Zimet GD We evaluated the acceptability of a community-based herpes simplex virus type 2 (HSV-2) screening programme for at-risk women and assessed factors related to uptake of point of care HSV-2 testing. One hundred recently arrested women (median age 34 years) were recruited from a community court handling lower-level misdemeanour cases in Indianapolis, Indiana. Individuals completed a survey assessing factors related to HSV-2 screening intentions and were offered point of care HSV-2 testing. Rates of HSV-2 infection in this population are high; 61.1% of women tested were positive. The majority (81%) accepted a prescription for suppressive therapy. Women in this sample indicated that HSV-2 screening is an important component of hea... Herpes journals http://www.medworm.com/rss/comments.php?id=4972826 Tue, 31 May 2011 23:00:00 +0100 4972826 http://www.medworm.com/index.php?rid=4972825&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21680672%26dopt%3DAbstract This study evaluated Euroline WB for the detection of HSV-2 antibodies compared with University of Washington Western blot in three geographically different regions: Baltimore, MD, USA; Rakai, Uganda; and Kunming, China. Among the 135 American men attending a STI clinic in Baltimore, MD, 72% (n = 97) were HSV-2-positive by Euroline WB, showing a sensitivity of 97.8% and a specificity of 81.8%. Among the 273 commercial sex workers in Kunming, 62.3% were HSV-2-positive by Euroline WB (sensitivity 96.9%, specificity 89.1%). Among the 437 Ugandans in Rakai, 67.3% were HSV-2-positive by Euroline WB (sensitivity 98.7%, specificity 65.4%). The Euroline WB has a consistently high sensitivity, but specificity varied significantly among the different locations. PMID: 21680672 [PubMed - in proces... Herpes journals http://www.medworm.com/rss/comments.php?id=4972825 Tue, 31 May 2011 23:00:00 +0100 4972825 http://www.medworm.com/index.php?rid=4972824&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21682148%26dopt%3DAbstract Authors: Colón-López V, Rodríguez-Díaz CE, Ortiz AP, Soto-Salgado M, Suárez E, Pérez CM Despite the growing impact of the human immunodeficiency virus (HIV) epidemic in Puerto Rico (PR), limited epidemiological research on men who have sex with men (MSM) has been conducted. The aim of this study was to describe HIV-related risk behaviors in a sample of MSM in PR. PMID: 21682148 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=4972824 Tue, 31 May 2011 23:00:00 +0100 4972824 http://www.medworm.com/index.php?rid=4972819&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21692200%26dopt%3DAbstract Conclusion: Adhesion molecules ICAM-1 and VCAM-1 were involved in the progression of herpex simplex keratitis. They may accelerate the progress of inflammation by mediating the extravsation of inflammatory cells from vessels into the infected sites. PMID: 21692200 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=4972819 Tue, 31 May 2011 23:00:00 +0100 4972819 http://www.medworm.com/index.php?rid=4771389&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21467713%26dopt%3DAbstract Authors: D Ku B, Sang Yoon S Relapsing herpes simplex encephalitis (HSE) rarely occurs after acyclovir treatment. We treated a patient with relapsing HSE of the contralateral temporal lobe, resulting in Klüver-Bucy syndrome, after a full-dose acyclovir treatment. This case suggests that physicians should consider sudden behavioral and emotional changes after HSE treatment as a possible indication of relapsing HSE, as well as possible temporal lobe epilepsy, and the need to administer longer acyclovir treatment for selectpatients. PMID: 21467713 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=4771389 Mon, 02 May 2011 08:30:03 +0100 4771389 http://www.medworm.com/index.php?rid=4771388&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21470498%26dopt%3DAbstract We present the case of a 66-year-old female after renal transplant with severe course of herpes zoster (HZ). Although HZ represents a common infectious complication of transplant patients, its variable manifestation and ability to disseminate warrants serious consideration. Prompt diagnosis and treatment are essential in preventing further spread and disastrous complications. PMID: 21470498 [PubMed - in process] (Source: Herpes) Herpes journals http://www.medworm.com/rss/comments.php?id=4771388 Mon, 02 May 2011 08:30:03 +0100 4771388 http://www.medworm.com/index.php?rid=4771387&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21483850%26dopt%3DAbstract Authors: Cheng SB, Ferland P, Webster P, Bearer EL Herpes simplex type 1 (HSV1) replicates in epithelial cells and secondarily enters local sensory neuronal processes, traveling retrograde to the neuronal nucleus to enter latency. Upon reawakening newly synthesized viral particles travel anterograde back to the epithelial cells of the lip, causing the recurrent cold sore. HSV1 co-purifies with amyloid precursor protein (APP), a cellular transmembrane glycoprotein and receptor for anterograde transport machinery that when proteolyzed produces A-beta, the major component of senile plaques. Here we focus on transport inside epithelial cells of newly synthesized virus during its transit to the cell surface. We hypothesize that HSV1 recruits cellular APP during transport. We explore this wi... Herpes journals http://www.medworm.com/rss/comments.php?id=4771387 Mon, 02 May 2011 08:30:03 +0100 4771387 http://www.medworm.com/index.php?rid=4771386&cid=s_33087_20_f&fid=33087&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21491367%26dopt%3DAbstract Authors: Ma YP, Ruan Q, Ji YH, Wang N, Li ML, Qi Y, He R, Sun ZR, Ren GW Human cytomegalovirus (HCMV) is a double-stranded DNA virus with the largest genome (~235 kb) of the known human herpes viruses. The coding potential and transcript structures of most HCMV predicted genes have not been identified. New or unknown genes could exist in clinical strains. The SMART (switching mechanism at 5ꞌ end of RNA template of reverse transcriptase) technique was used to construct a full-length cDNA library of an HCMV clinical strain in the late expression phase. Randomly selected clones were sequenced. The sequenced expressed sequence tags were used to identify the expression and transcript structures of some predicted and unpredicted genes of HCMV. The transcripts of the UL99, TRL5/IRL5, UL73 t... Herpes journals http://www.medworm.com/rss/comments.php?id=4771386 Mon, 02 May 2011 08:30:03 +0100 4771386