MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Human Reproduction Update' source. Sun, 05 Feb 2012 22:55:16 +0100 http://www.medworm.com/index.php?rid=5488811&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F18%2F1%2F92%3Frss%3D1 CONCLUSIONS The HLA class Ib molecules seem to induce suppression of the maternal immune system, but are not necessarily fundamental factors for pregnancy success. However, evidence points towards low expression of these proteins, especially HLA-G, being associated with reduced fertility. To clarify the functions of HLA-E, -F and -G future studies need to link investigations of the polymorphisms in these genes to measurements of protein levels, and examine the role of these proteins in the complex interplay of immune cells and cytokines at the materno-fetal interface. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=5488811 Wed, 07 Dec 2011 05:00:00 +0100 5488811 http://www.medworm.com/index.php?rid=5488810&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F18%2F1%2F73%3Frss%3D1 CONCLUSIONS There is increasing evidence to indicate that multiple waves of antral follicles develop during the human menstrual cycle. Ovarian follicular waves in women are comparable with those documented in several animal species; however, species-specific differences exist. Enhancing our understanding of the endocrine and paracrine mechanisms underlying antral follicular wave dynamics has clinical implications for understanding age-related changes in reproductive function, optimizing hormonal contraceptive and ovarian stimulation regimens and identifying non-invasive markers of the physiologic status of follicles which are predictive of oocyte competence and assisted reproduction outcomes. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=5488810 Wed, 07 Dec 2011 05:00:00 +0100 5488810 http://www.medworm.com/index.php?rid=5488809&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F18%2F1%2F60%3Frss%3D1 CONCLUSIONS SAC and its regulators exist and function in meiosis, and their malfunctions may cause germ cell aneuploidy. However, species and sexual differences exist. Moreover, interaction of SAC components with other regulators is still poorly understood, which needs further study. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=5488809 Wed, 07 Dec 2011 05:00:00 +0100 5488809 http://www.medworm.com/index.php?rid=5488808&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F18%2F1%2F44%3Frss%3D1 CONCLUSIONS miRNA plays an essential role in regulation of genes during the process of spermatogenesis. Disruption of this regulation has the ability to contribute to the neoplastic development of germ cell tumours. However, targeted knockdown of specific miRNA molecules has the potential to form both anti-oncogenic reagents and underpin the basis for novel contraceptive technologies. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=5488808 Wed, 07 Dec 2011 05:00:00 +0100 5488808 http://www.medworm.com/index.php?rid=5488807&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F18%2F1%2F29%3Frss%3D1 CONCLUSIONS In general, women have partners who are several years older than themselves and it is important to focus more on the combined effect of higher female and male age on infertility and reproductive outcome. Increasing public awareness of the impact of advanced female and male age on the reproductive outcome is essential for people to make well-informed decisions on when to start family formation. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=5488807 Wed, 07 Dec 2011 05:00:00 +0100 5488807 http://www.medworm.com/index.php?rid=5488806&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F18%2F1%2F12%3Frss%3D1 CONCLUSIONS The severity of endocrine toxicity after childhood Hodgkin's lymphoma depends on the type of treatment. Gonadal dysfunction seems to be the most severe endocrine long-term effect, especially after treatment with alkylating agents or pelvic radiotherapy. The knowledge obtained in specific follow-up programmes for paediatric cancer survivors will help to find the optimal balance between curability and long-term side effects. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=5488806 Wed, 07 Dec 2011 05:00:00 +0100 5488806 http://www.medworm.com/index.php?rid=5488805&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F18%2F1%2F1%3Frss%3D1 CONCLUSIONS Poor responders are not a homogeneous group of women with regards to pregnancy prospects. Female age and number of oocytes retrieved in particular will modulate the chances for pregnancy in current and subsequent cycles. Applying these criteria will allow the identification of couples with a reasonable prognosis and balanced decision-making on the management of poor responders. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=5488805 Wed, 07 Dec 2011 05:00:00 +0100 5488805 http://www.medworm.com/index.php?rid=5317190&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F6%2F861-a%3Frss%3D1 (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=5317190 Wed, 12 Oct 2011 04:00:00 +0100 5317190 http://www.medworm.com/index.php?rid=5317189&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F6%2F861%3Frss%3D1 (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=5317189 Wed, 12 Oct 2011 04:00:00 +0100 5317189 http://www.medworm.com/index.php?rid=5317188&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F6%2F848%3Frss%3D1 CONCLUSIONS The postponement of first births has implications on the ability of women to conceive and parents to produce additional offspring. Massive postponement is attributed to the clash between the optimal biological period for women to have children with obtaining additional education and building a career. A growing body of literature shows that female employment and childrearing can be combined when the reduction in work–family conflict is facilitated by policy intervention. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=5317188 Wed, 12 Oct 2011 04:00:00 +0100 5317188 http://www.medworm.com/index.php?rid=5317187&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F6%2F829%3Frss%3D1 CONCLUSIONS The way forward in advancing the knowledge of genes involved in reproduction was considered to be through genome-wide association studies involving large numbers of patients. Establishing international collaboration is required to enable the application of such technologies in sufficient numbers of patients. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=5317187 Wed, 12 Oct 2011 04:00:00 +0100 5317187 http://www.medworm.com/index.php?rid=5317186&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F6%2F813%3Frss%3D1 CONCLUSIONS Although data are accumulating with evidence suggesting that the ovarian response to COH is mediated by various polymorphisms, the optimal biomarkers and the efficacy of the tests still remain to be evaluated. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=5317186 Wed, 12 Oct 2011 04:00:00 +0100 5317186 http://www.medworm.com/index.php?rid=5317185&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F6%2F803%3Frss%3D1 CONCLUSIONS Meta-analyses of available data showed significant associations between the VEGF (–1154G>A), p53 (codon72) and eNOS (Glu298Asp) polymorphisms and idiopathic RPL. These angiogenesis- and vasoconstriction-related genes jointly confer higher susceptibility to idiopathic RPL. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=5317185 Wed, 12 Oct 2011 04:00:00 +0100 5317185 http://www.medworm.com/index.php?rid=5317184&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F6%2F791%3Frss%3D1 CONCLUSIONS Greater scrutiny of the preclinical efficacy models, end-points and experimental designs is needed if the desire of translating novel treatment approaches is to be realized for women with endometriosis. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=5317184 Wed, 12 Oct 2011 04:00:00 +0100 5317184 http://www.medworm.com/index.php?rid=5317183&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F6%2F772%3Frss%3D1 CONCLUSIONS Growth factors play an important role in the mechanisms involved in myometrial patho-physiology. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=5317183 Wed, 12 Oct 2011 04:00:00 +0100 5317183 http://www.medworm.com/index.php?rid=5317182&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F6%2F761%3Frss%3D1 CONCLUSIONS Women with a history of miscarriage or miscarriage and infertility have higher prevalence of congenital uterine anomalies compared with the unselected population. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=5317182 Wed, 12 Oct 2011 04:00:00 +0100 5317182 http://www.medworm.com/index.php?rid=5317181&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F6%2F741%3Frss%3D1 CONCLUSIONS Women with PCOS have increased serum concentrations of CVD risk markers compared with controls. Whether this apparent risk is translated into increased incidence of CVD in later life remains to be elucidated. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=5317181 Wed, 12 Oct 2011 04:00:00 +0100 5317181 http://www.medworm.com/index.php?rid=5317180&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F6%2F734%3Frss%3D1 CONCLUSIONS The best available evidence suggests that GnRH agonist addition during the luteal phase significantly increases the probability of live birth rates. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=5317180 Wed, 12 Oct 2011 04:00:00 +0100 5317180 http://www.medworm.com/index.php?rid=5317179&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F6%2F719%3Frss%3D1 CONCLUSIONS While some of the advanced sperm selection methods are of value in specific clinical ART settings, others are in need of further evaluation. More clinical studies on safety and efficacy are needed before the implementation of advanced sperm selection methods could be universally recommended in ART. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=5317179 Wed, 12 Oct 2011 04:00:00 +0100 5317179 http://www.medworm.com/index.php?rid=5133984&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F5%2F706%3Frss%3D1 CONCLUSIONS Lifestyle changes around the time of the perimenopause can reduce the likelihood and severity of heart disease and chronic illness in later years and the cost of care of elderly women. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=5133984 Mon, 15 Aug 2011 23:00:00 +0100 5133984 http://www.medworm.com/index.php?rid=5133983&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F5%2F693%3Frss%3D1 CONCLUSIONS Accepting the need for a new classification system of genitourinary malformations that considers the experience gained from the application of the current classification systems, the aetiopathogenesis and that also suggests the appropriate treatment, we proposed an update of our embryological–clinical classification as a new system with six groups of female genitourinary anomalies. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=5133983 Mon, 15 Aug 2011 23:00:00 +0100 5133983 http://www.medworm.com/index.php?rid=5133982&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F5%2F684%3Frss%3D1 CONCLUSIONS Absolute immotile spermatozoa is one of the most important causes of reduced fertilization and pregnancy rates after ICSI and different techniques are used to improve ICSI outcomes. However, it still remains unclear which is the best technique to improve the pregnancy outcomes in these couples. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=5133982 Mon, 15 Aug 2011 23:00:00 +0100 5133982 http://www.medworm.com/index.php?rid=5133981&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F5%2F667%3Frss%3D1 CONCLUSIONS Infertility in overweight/obese males may be explained by leptin insensitivity. This implies a possible role for the KISS1 system in human obesity-related male infertility. If substantiated, it will pave the way for methods to restore fertility in these subjects. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=5133981 Mon, 15 Aug 2011 23:00:00 +0100 5133981 http://www.medworm.com/index.php?rid=5133980&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F5%2F654%3Frss%3D1 Conclusions The majority of studies are observational studies and were not performed in a randomized manner and there is no direct comparison of techniques using other gamete selection markers. Despite this, most studies show that polarization microscopy may help us to further increase our knowledge on gametes and meiosis. Whether certain applications such as spindle or zona imaging may lead to an increase in IVF success is unclear at present. Publications on the use of polarization microscopy on sperm are still very limited. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=5133980 Mon, 15 Aug 2011 23:00:00 +0100 5133980 http://www.medworm.com/index.php?rid=5133979&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F5%2F637%3Frss%3D1 CONCLUSIONS This systematic review identified several reports of endometrial differences which have the potential to be biomarkers of endometriosis. However, larger studies in well-defined populations are clearly required to determine their true usefulness. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=5133979 Mon, 15 Aug 2011 23:00:00 +0100 5133979 http://www.medworm.com/index.php?rid=5133978&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F5%2F628%3Frss%3D1 CONCLUSIONS The involvement of vasculogenesis in endometriosis may offer the exciting opportunity for the future establishment of novel diagnostic and therapeutic strategies for this frequent gynaecological disease. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=5133978 Mon, 15 Aug 2011 23:00:00 +0100 5133978 http://www.medworm.com/index.php?rid=5133977&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F5%2F620%3Frss%3D1 CONCLUSIONS Diploid–aneuploid mosaicism is by far the most common chromosomal constitution in spare human preimplantation embryos after IVF. This undermines the reliable determination of the ploidy status of a cleavage-stage embryo based on the analysis of a single cell. Future research should determine the origin and developmental potential of mosaic embryos. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=5133977 Mon, 15 Aug 2011 23:00:00 +0100 5133977 http://www.medworm.com/index.php?rid=5133976&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F5%2F605%3Frss%3D1 CONCLUSIONS Pregnant women with subclinical hypothyroidism or thyroid antibodies have an increased risk of complications, especially pre-eclampsia, perinatal mortality and (recurrent) miscarriage. Future research, within the setting of clinical trials, should focus on the potential health gain of identification, and effect of treatment, of thyroid disease on pregnancy outcome. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=5133976 Mon, 15 Aug 2011 23:00:00 +0100 5133976 http://www.medworm.com/index.php?rid=5133975&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F5%2F589%3Frss%3D1 CONCLUSIONS Birth defects that are positively associated with maternal smoking should now be included in public health educational materials to encourage more women to quit before or during pregnancy. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=5133975 Mon, 15 Aug 2011 23:00:00 +0100 5133975 http://www.medworm.com/index.php?rid=5133974&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F5%2F575%3Frss%3D1 CONCLUSIONS There is a need for an agreed definition for infertility. We suggest a clinically relevant definition based on the duration of trying for pregnancy coupled with female age. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=5133974 Mon, 15 Aug 2011 23:00:00 +0100 5133974 http://www.medworm.com/index.php?rid=4906427&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F4%2F558%3Frss%3D1 CONCLUSIONS Epidemiological, immunogenetic and immunological studies support the hypothesis that aberrant maternal H-Y immune responses have a pathogenic role in SRM. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4906427 Sun, 05 Jun 2011 23:00:00 +0100 4906427 http://www.medworm.com/index.php?rid=4906426&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F4%2F541%3Frss%3D1 CONCLUSIONS Although several factors remain to be studied to optimize efficiency, manipulations of the embryo culture microenvironment through novel culture devices may offer a means to improve embryo development in vitro. Reduced volume systems that reduce embryo spacing, such as the well-of-the-well approach, appear beneficial, although more work is needed to verify the source of their true benefit in human embryos. Emerging microfluidic technology appears to be a promising approach. However, along with the work on specialized culture surfaces, more information is required to determine the impact on human embryo development. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4906426 Sun, 05 Jun 2011 23:00:00 +0100 4906426 http://www.medworm.com/index.php?rid=4906425&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F4%2F525%3Frss%3D1 CONCLUSIONS The multifaceted complex of factors involved in oocyte growth constitutes the backbone on which oocyte developmental competence is built up. Operating behind the expression of these factors is a specific epigenetic signature established during oogenesis, but our knowledge is only approximate and major efforts will be required for more accurate analyses at specific gene loci. The growing research on small silencing RNAs during oogenesis and early oocyte development is revealing these molecules’ critical role in mRNA degradation. Our next challenge will be to dissect the complex interactions among the different molecular players identified and to establish the presence of functional links among these factors. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4906425 Sun, 05 Jun 2011 23:00:00 +0100 4906425 http://www.medworm.com/index.php?rid=4906424&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F4%2F510%3Frss%3D1 CONCLUSIONS GnRHa triggering is a valid alternative to hCG triggering, resulting in an elimination of OHSS. After modified luteal support there is now a non-significant difference of 6% in delivery rate in favour of hCG triggering. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4906424 Sun, 05 Jun 2011 23:00:00 +0100 4906424 http://www.medworm.com/index.php?rid=4906423&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F4%2F501%3Frss%3D1 CONCLUSIONS Aspirin does not improve pregnancy rates after IVF. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4906423 Sun, 05 Jun 2011 23:00:00 +0100 4906423 http://www.medworm.com/index.php?rid=4906422&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F4%2F495%3Frss%3D1 CONCLUSIONS This meta-analysis showed a 2-fold risk of arterial disease for patients with PCOS relative to women without PCOS. BMI adjustment did not affect this finding, suggesting the increased risk for cardiovascular events in PCOS is not completely related to a higher BMI in patients with PCOS. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4906422 Sun, 05 Jun 2011 23:00:00 +0100 4906422 http://www.medworm.com/index.php?rid=4906421&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F4%2F476%3Frss%3D1 CONCLUSIONS Despite the increasing understanding of the mechanisms involved in their genesis, CCRs arise as unique, complex events for which the genetic and reproductive counseling of carriers remains a challenge. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4906421 Sun, 05 Jun 2011 23:00:00 +0100 4906421 http://www.medworm.com/index.php?rid=4906420&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F4%2F467%3Frss%3D1 CONCLUSIONS Currently, there are insufficient data indicating that PGD improves the live birth rate in couples with RM carrying a structural chromosome abnormality. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4906420 Sun, 05 Jun 2011 23:00:00 +0100 4906420 http://www.medworm.com/index.php?rid=4906419&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F4%2F454%3Frss%3D1 CONCLUSIONS There is no evidence of a beneficial effect of PGS as currently applied on the live birth rate after IVF. On the contrary, for women of advanced maternal age PGS significantly lowers the live birth rate. Technical drawbacks and chromosomal mosaicism underlie this inefficacy of PGS. New approaches in the application of PGS should be evaluated carefully before their introduction into clinical practice. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4906419 Sun, 05 Jun 2011 23:00:00 +0100 4906419 http://www.medworm.com/index.php?rid=4906418&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F4%2F438%3Frss%3D1 CONCLUSIONS AH was related to increased clinical pregnancy and multiple pregnancy rates in women with previous repeated failure or frozen-thawed embryos. However, AH is unlikely to increase clinical pregnancy rates when performed in fresh embryos transferred to unselected or non-poor prognosis women or to women of advanced age. Due to the small sample evaluated by the pool of included studies, no proper conclusions could be drawn regarding miscarriage or live birth. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4906418 Sun, 05 Jun 2011 23:00:00 +0100 4906418 http://www.medworm.com/index.php?rid=4906417&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F4%2F436%3Frss%3D1 (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4906417 Sun, 05 Jun 2011 23:00:00 +0100 4906417 http://www.medworm.com/index.php?rid=4906416&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F4%2F435%3Frss%3D1 (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4906416 Sun, 05 Jun 2011 23:00:00 +0100 4906416 http://www.medworm.com/index.php?rid=4688496&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F3%2F434%3Frss%3D1 (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4688496 Wed, 06 Apr 2011 23:00:00 +0100 4688496 http://www.medworm.com/index.php?rid=4688495&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F3%2F418%3Frss%3D1 CONCLUSIONS A detailed appraisal of compounds specifically related to adverse reproductive outcomes is very important for prevention and risk-communication strategies. Besides research needs, the current evidence is sufficient to prompt precautionary actions to protect women's reproductive health. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4688495 Wed, 06 Apr 2011 23:00:00 +0100 4688495 http://www.medworm.com/index.php?rid=4688494&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F3%2F397%3Frss%3D1 CONCLUSIONS Studies in both animals and humans have made it increasingly clear that proper epigenetic regulation of both imprinted and non-imprinted genes is important in placental development. Its disturbance, which can be caused by various environmental factors, can lead to abnormal placental development and function with possible consequences for maternal morbidity, fetal development and disease susceptibility in later life. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4688494 Wed, 06 Apr 2011 23:00:00 +0100 4688494 http://www.medworm.com/index.php?rid=4688493&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F3%2F383%3Frss%3D1 CONCLUSIONS MCs are prevalent in the female and male reproductive tract. However, whether MCs are absolutely required for a successful pregnancy or are fundamental to reproductive pathology, and thereby a therapeutic target, remains to be determined. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4688493 Wed, 06 Apr 2011 23:00:00 +0100 4688493 http://www.medworm.com/index.php?rid=4688492&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F3%2F372%3Frss%3D1 CONCLUSIONS The technical advances for non-invasive aneuploidy tests based on cff DNA and placental mRNA in maternal plasma have been enormous. Multimarker assays including genome-wide approaches with the option of qualitative information on variation (polymorphism or mutation) besides quantitative information are the preferred methods of choice. The time for population-based, double blind, large-scale clinical cohort trials has come. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4688492 Wed, 06 Apr 2011 23:00:00 +0100 4688492 http://www.medworm.com/index.php?rid=4688491&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F3%2F362%3Frss%3D1 CONCLUSIONS AF supernatant is a valuable and widely available but under-utilized biological resource. Further studies of cff nucleic acids in AF may lead to new insights into human fetal development and ultimately new approaches to antenatal treatment of human disease. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4688491 Wed, 06 Apr 2011 23:00:00 +0100 4688491 http://www.medworm.com/index.php?rid=4688490&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F3%2F347%3Frss%3D1 CONCLUSIONS The available studies suggest that tight control of the endocannabinoid–hormone–cytokine network is required for successful implantation and early pregnancy maintenance. This hormone–cytokine network is a key element at the maternal–foetal interface, and any defect in such a network may result in foetal loss. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4688490 Wed, 06 Apr 2011 23:00:00 +0100 4688490 http://www.medworm.com/index.php?rid=4688489&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F3%2F327%3Frss%3D1 CONCLUSIONS Major advances in improving understanding and alleviating pain in endometriosis will likely occur if the focus changes from lesions to pain. In turn, how endometriosis affects the CNS would be best examined in the context of mechanisms underlying other chronic pain conditions. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4688489 Wed, 06 Apr 2011 23:00:00 +0100 4688489 http://www.medworm.com/index.php?rid=4688488&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F3%2F311%3Frss%3D1 CONCLUSIONS Prospective studies reporting standardized and well-defined clinical outcome after surgical treatment of DIE with colorectal involvement with long-term follow-up are needed. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4688488 Wed, 06 Apr 2011 23:00:00 +0100 4688488 http://www.medworm.com/index.php?rid=4688487&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F3%2F301%3Frss%3D1 CONCLUSIONS In Chlamydia antibody testing, MIF is superior in the assessment of tubal pathology. In the initial screen for tubal pathology MIF should therefore be the test of first choice. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4688487 Wed, 06 Apr 2011 23:00:00 +0100 4688487 http://www.medworm.com/index.php?rid=4688486&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F3%2F293%3Frss%3D1 CONCLUSIONS The accuracy of HSG in detecting tubal pathology was similar in all subgroups, except for women without risk factors in whom sensitivity was lower, possibly due to false-positive results at laparoscopy. HSG is a useful tubal patency screening test for all infertile couples. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4688486 Wed, 06 Apr 2011 23:00:00 +0100 4688486 http://www.medworm.com/index.php?rid=4479449&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F2%2F291%3Frss%3D1 (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4479449 Tue, 15 Feb 2011 00:00:00 +0100 4479449 http://www.medworm.com/index.php?rid=4479448&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F2%2F272%3Frss%3D1 CONCLUSIONS Omics analysis provides tools for understanding the molecular mechanisms and signaling pathways controlling early embryonic development. Furthermore, we discuss the clinical relevance of using a non-invasive molecular approach to embryo selection for the single-embryo transfer program. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4479448 Tue, 15 Feb 2011 00:00:00 +0100 4479448 http://www.medworm.com/index.php?rid=4479447&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F2%2F254%3Frss%3D1 CONCLUSIONS In order to further our knowledge of the mechanisms underlying self-renewal and pluripotency, a thorough comparison between different pluripotent stem cell types is required. This will progress the use of stem cells in basic biology, drug discovery and future clinical applications. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4479447 Tue, 15 Feb 2011 00:00:00 +0100 4479447 http://www.medworm.com/index.php?rid=4479446&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F2%2F242%3Frss%3D1 CONCLUSIONS Optimizing endometrial receptivity in fertility treatment will improve success rates. Evaluation of implantation markers may help to predict pregnancy outcome and detect occult implantation deficiency. Treating the underlying gynecological disease with medical or surgical interventions is the optimal current therapy. Manipulating the expression of key endometrial genes with gene or stem cell-based therapies may some day be used to further improve implantation rates. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4479446 Tue, 15 Feb 2011 00:00:00 +0100 4479446 http://www.medworm.com/index.php?rid=4479445&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F2%2F228%3Frss%3D1 CONCLUSIONS A range of NMR spectroscopic techniques have been applied to the analysis of the female reproductive tract, however great potential remains for further studies. Incorporation of metabonomics techniques into female fertility research may be valuable for understanding subfertility and predicting outcomes of assisted conception treatments. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4479445 Tue, 15 Feb 2011 00:00:00 +0100 4479445 http://www.medworm.com/index.php?rid=4479444&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F2%2F210%3Frss%3D1 CONCLUSIONS Currently, the impact of early life events on reproductive health and disease risk is poorly understood. It is clear, however, that nutrition spanning the entire developmental lifespan plays an integral role. Improved insight into the underlying mechanisms is likely to have significant implications for our current understanding of reproductive disorders, and therefore for the health and reproductive potential of future generations. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4479444 Tue, 15 Feb 2011 00:00:00 +0100 4479444 http://www.medworm.com/index.php?rid=4479443&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F2%2F197%3Frss%3D1 CONCLUSIONS Our meta-analysis comprising >12 000 men demonstrates that gr/gr deletions occur more frequently in infertile than control men. The association between gr/gr deletions and infertility varies according to ethnicity and geographic region, with an association reaching significance among Caucasian men, in Europe and the Western Pacific region. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4479443 Tue, 15 Feb 2011 00:00:00 +0100 4479443 http://www.medworm.com/index.php?rid=4479442&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F2%2F184%3Frss%3D1 CONCLUSIONS This meta-analysis suggests that the optimal daily recFSH stimulation dose is 150 IU/day in presumed normal responders younger than 39 years undergoing IVF. Compared with higher doses, this dose is associated with a slightly lower oocyte yield, but similar pregnancy and embryo cryopreservation rates. Furthermore, the wide spread adherence to this optimal dose will allow for a considerable reduction in IVF costs and complications. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4479442 Tue, 15 Feb 2011 00:00:00 +0100 4479442 http://www.medworm.com/index.php?rid=4479441&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F2%2F171%3Frss%3D1 CONCLUSIONS Exercise-specific interventions in PCOS are limited. Studies vary considerably in design, intensity and outcome measures; therefore conclusive results remain elusive. Larger, optimally designed studies are needed to both gain insights into the mechanisms of exercise action and to evaluate the public health impact of exercise of PCOS. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4479441 Tue, 15 Feb 2011 00:00:00 +0100 4479441 http://www.medworm.com/index.php?rid=4479440&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F2%2F159%3Frss%3D1 CONCLUSIONS The risk of endometriosis appears reduced during OC use. However, it is not possible to exclude the possibility that the apparent protective effect of OC against endometriosis is the result of postponement of surgical evaluation due to temporary suppression of pain symptoms. Confounding by selection and indication biases may explain the trend towards an increase in risk of endometriosis observed after discontinuation, but further clarification is needed. To date, the hypothesis of recommending OCs for primary prevention of endometriosis does not seem sufficiently substantiated. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4479440 Tue, 15 Feb 2011 00:00:00 +0100 4479440 http://www.medworm.com/index.php?rid=4479439&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F2%2F141%3Frss%3D1 CONCLUSIONS The findings explain the erratic fertility of women and why ovulation is not always associated with fertility. They provide an understanding of the various types of ovarian activity and their relation to pituitary function, fertility and uterine bleeding. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4479439 Tue, 15 Feb 2011 00:00:00 +0100 4479439 http://www.medworm.com/index.php?rid=4479438&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F2%2F139%3Frss%3D1 (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4479438 Tue, 15 Feb 2011 00:00:00 +0100 4479438 http://www.medworm.com/index.php?rid=4255324&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F1%2F138%3Frss%3D1 (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4255324 Mon, 13 Dec 2010 00:00:00 +0100 4255324 http://www.medworm.com/index.php?rid=4255323&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F1%2F121%3Frss%3D1 CONCLUSIONS LARC methods—copper intrauterine devices (IUDs), progestogen-releasing intrauterine system and injectable and implantable contraceptives—are safe and effective contraceptive options (unintended pregnancy rates with typical versus perfect use: 0.05–3.0 versus 0.05–0.6%) that are appropriate for a wide range of women seeking to limit or space childbearing. Despite their safety and efficacy records, these methods remain underutilized; injectable and implantable methods are used by an estimated 3.4% and intrauterine methods by 15.5% of women worldwide. LARC methods require no daily or coital adherence and avoid the adverse events and health risks of estrogen-containing contraceptives. The copper IUD and progestin-only injections and implants have been shown ... Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4255323 Mon, 13 Dec 2010 00:00:00 +0100 4255323 http://www.medworm.com/index.php?rid=4255322&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F1%2F107%3Frss%3D1 CONCLUSIONS The current variation in the uptake of elective SET is likely to persist until there are major changes in the way ART is viewed, funded and legislated. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4255322 Mon, 13 Dec 2010 00:00:00 +0100 4255322 http://www.medworm.com/index.php?rid=4255321&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F1%2F96%3Frss%3D1 CONCLUSIONS Studies included in this review were often limited by small samples and lack of appropriate comparison groups, making further research in this area essential. In particular, lack of control for maternal psychiatric history and other important sociodemographic predictors of depression is a serious limitation of existing research on this topic. Further, the use of reproductive technologies and multiple births often co-occur, and few study designs enabled separation of the effects of these two variables. However, evidence of increased risk for symptoms of postpartum depression among women with multiple births, if confirmed, may warrant targeted interventions for this population. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4255321 Mon, 13 Dec 2010 00:00:00 +0100 4255321 http://www.medworm.com/index.php?rid=4255320&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F1%2F76%3Frss%3D1 CONCLUSIONS All stages of reproductive functions are targets of cigarette smoke toxicants. Further studies are necessary to better understand the deleterious effects of cigarette smoke compounds on the reproductive system in order to improve health care, help to reduce cigarette smoking and provide a better knowledge of the molecular mechanisms involved in reproductive toxicology. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4255320 Mon, 13 Dec 2010 00:00:00 +0100 4255320 http://www.medworm.com/index.php?rid=4255319&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F1%2F68%3Frss%3D1 CONCLUSIONS The two successive divisions that comprise mammalian oogenesis are asymmetric. They lead to the formation of small polar bodies and the large and polarized egg. This asymmetry depends upon the dynamic organization of the oocyte cytoskeleton during both divisions. During meiosis I, microfilaments and associated molecules ensure the targeting of the microtubule spindle at the oocyte periphery. During meiosis II, they anchor the spindle under the plasma membrane. In parallel, the cortex overhanging the spindle is dramatically reorganized. Establishment and maintenance of this cortical domain are crucial for the completion of fertilization. Loss of this differentiated area is characteristic of ageing or low-quality gametes and associated with increased maternal age or post-ovulator... Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4255319 Mon, 13 Dec 2010 00:00:00 +0100 4255319 http://www.medworm.com/index.php?rid=4255318&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F1%2F55%3Frss%3D1 CONCLUSIONS The review of relevant articles, as well as the meta-analysis of selected studies, yields consistent data on a significant reduction of OC risk in women who had undergone TL. The results of this meta-analysis should provide an impulse for further research on the etiology of ovarian epithelial cancers, focusing particularly on the importance of retrograde transport of endometrial cells. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4255318 Mon, 13 Dec 2010 00:00:00 +0100 4255318 http://www.medworm.com/index.php?rid=4255317&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F1%2F46%3Frss%3D1 CONCLUSIONS Both AMH and AFC are accurate predictors of excessive response to ovarian hyperstimulation. Moreover, both tests appear to have clinical value. This opens ways to explore the potential of individualized FSH dose regimens based on ovarian reserve testing. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4255317 Mon, 13 Dec 2010 00:00:00 +0100 4255317 http://www.medworm.com/index.php?rid=4255316&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F1%2F34%3Frss%3D1 CONCLUSIONS No clear tendency in recent publications to a general increase in predictive value of morphological features was found. These contradicting data underline the importance of more intensive and coordinated research to reach a consensus and fully exploit the predictive potential of morphological examination of human oocytes. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4255316 Mon, 13 Dec 2010 00:00:00 +0100 4255316 http://www.medworm.com/index.php?rid=4255315&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F1%2F17%3Frss%3D1 CONCLUSIONS Any abnormality in the extra- and/or intra-ovarian factors may negatively affect the granulosa cell–oocyte interaction, oocyte maturation and potential embryonic developmental competence, contributing to unsuccessful outcomes for patients with PCOS who are undergoing assisted reproduction. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4255315 Mon, 13 Dec 2010 00:00:00 +0100 4255315 http://www.medworm.com/index.php?rid=4255314&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F1%2F4%3Frss%3D1 CONCLUSION These data indicate that a decreased serum level of IGFBP-1 is unlikely to be a mechanism for ovarian hyperandrogenism in PCOS. BMI may be the major determinant of serum IGFBP-1. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4255314 Mon, 13 Dec 2010 00:00:00 +0100 4255314 http://www.medworm.com/index.php?rid=4255313&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F1%2F3%3Frss%3D1 (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4255313 Mon, 13 Dec 2010 00:00:00 +0100 4255313 http://www.medworm.com/index.php?rid=4255312&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F1%2F2%3Frss%3D1 (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4255312 Mon, 13 Dec 2010 00:00:00 +0100 4255312 http://www.medworm.com/index.php?rid=4255311&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F17%2F1%2F1%3Frss%3D1 (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4255311 Mon, 13 Dec 2010 00:00:00 +0100 4255311 http://www.medworm.com/index.php?rid=4063170&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F6%2F761%3Frss%3D1 CONCLUSIONS Although diagnosis of osteoporosis is an important step, the threshold for treatment to prevent fractures depends on additional clinical risk factors. None of the presently available treatment options provide complete fracture prevention. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4063170 Tue, 12 Oct 2010 23:00:00 +0100 4063170 http://www.medworm.com/index.php?rid=4063169&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F6%2F745%3Frss%3D1 CONCLUSIONS Isoflavone intake does not alter breast density in post-menopausal women, but may cause a small increase in breast density in premenopausal women. Larger, long-term trials are required to determine if these small effects are clinically relevant. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4063169 Tue, 12 Oct 2010 23:00:00 +0100 4063169 http://www.medworm.com/index.php?rid=4063168&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F6%2F725%3Frss%3D1 CONCLUSIONS More research is necessary to understand the mechanisms that generate the frequency, amplitude, duration and direction of propagation of uterine contractile activity. On the basis of current knowledge of the molecular control of uterine myocyte function, there are opportunities for systematic testing of the efficacy of a variety of available potential pharmacological agents and for the development of new agents. Taking advantage of these opportunities could result in an overall improvement in reproductive health. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4063168 Tue, 12 Oct 2010 23:00:00 +0100 4063168 http://www.medworm.com/index.php?rid=4063167&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F6%2F713%3Frss%3D1 CONCLUSIONS Serum Inh-B cannot serve as a stand-alone marker of persistent spermatogenesis in men with NOA. Although limited, evidence on serum AMH and serum/seminal AMH do not support their diagnostic value in men with NOA. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4063167 Tue, 12 Oct 2010 23:00:00 +0100 4063167 http://www.medworm.com/index.php?rid=4063166&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F6%2F704%3Frss%3D1 CONCLUSIONS ED pregnancies have a higher risk of maternal morbidity. Owing to the high degree of antigenic dissimilarity, ED pregnancies represent an interesting model to study complex immunologic interactions, as the fully allogeneic fetus is not rejected but tolerated by the pregnant woman. Knowledge of the immune system in ED pregnancies has broader significance, as it may also give insight into immunologic aspects of tolerance in solid organ transplantation. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4063166 Tue, 12 Oct 2010 23:00:00 +0100 4063166 http://www.medworm.com/index.php?rid=4063165&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F6%2F690%3Frss%3D1 CONCLUSIONS Although ICSI results in average fertilization rates of 70%, complete or virtually complete fertilization failure still occurs in 1–5% of ICSI cycles. While oocyte activation failure can, in some cases, be overcome by artificial oocyte activators such as calcium ionophores, a more physiological oocyte activation agent might release Ca2+ within the oocyte in a more efficient and controlled manner. As PLC is now widely considered to be the physiological agent responsible for activating mammalian oocytes, it represents both a novel diagnostic biomarker of oocyte activation capability and a possible mode of treatment for certain types of male infertility. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4063165 Tue, 12 Oct 2010 23:00:00 +0100 4063165 http://www.medworm.com/index.php?rid=4063164&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F6%2F675%3Frss%3D1 CONCLUSIONS The data from the meta-analyses suggests that the effect on clinical outcome of gonadotrophin priming of IVM still needs to be studied. In order to improve the IVM programs, it is essential to define not only the clinical aspects but also the laboratory and embryological aspects. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4063164 Tue, 12 Oct 2010 23:00:00 +0100 4063164 http://www.medworm.com/index.php?rid=4063163&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F6%2F651%3Frss%3D1 CONCLUSIONS Peripheral biomarkers show promise as diagnostic aids, but further research is necessary before they can be recommended in routine clinical care. Panels of markers may allow increased sensitivity and specificity of any diagnostic test. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4063163 Tue, 12 Oct 2010 23:00:00 +0100 4063163 http://www.medworm.com/index.php?rid=4063162&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F6%2F631%3Frss%3D1 CONCLUSIONS Women wishing to use combined OC can be reassured that their decision is unlikely to place them at higher risk of developing cancer. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4063162 Tue, 12 Oct 2010 23:00:00 +0100 4063162 http://www.medworm.com/index.php?rid=4063161&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F6%2F617%3Frss%3D1 CONCLUSION Our review suggests that ovarian cortex cryopreservation is feasible and as safe as comparable operative procedures in children. Although no births have yet resulted from freeze-thawing of prepubertal ovarian cortex, the results of this approach in adults are encouraging. However, the absence of consensus on the indications for fertility preservation, as well as the optimal timing and quantity of ovarian cortex for cryopreservation, should be taken into consideration when discussing fertility issues with girls at risk of POF and their parents. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4063161 Tue, 12 Oct 2010 23:00:00 +0100 4063161 http://www.medworm.com/index.php?rid=4063160&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F6%2F614%3Frss%3D1 (No abstract is available for this citation) (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4063160 Tue, 12 Oct 2010 23:00:00 +0100 4063160 http://www.medworm.com/index.php?rid=4063159&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F6%2F603%3Frss%3D1 CONCLUSIONS The complex interaction between the cost of ART treatment and how treatments are subsidized in different healthcare settings and for different patient groups has far-reaching consequences for ART utilization, clinical practice and infant outcomes. A greater understanding of the economics of ART is needed to inform policy decisions and to ensure the best possible outcomes from ART treatment. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4063159 Tue, 12 Oct 2010 23:00:00 +0100 4063159 http://www.medworm.com/index.php?rid=4063158&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F6%2F590%3Frss%3D1 CONCLUSIONS Societal support for families and for couples trying to conceive improves the lives of families but makes no substantial contribution to increased fertility rates. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4063158 Tue, 12 Oct 2010 23:00:00 +0100 4063158 http://www.medworm.com/index.php?rid=4063157&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F6%2F577%3Frss%3D1 CONCLUSIONS Female age, duration of subfertility, bFSH and number of oocytes, all reflecting ovarian function, are predictors of pregnancy after IVF. Better quality studies are necessary, especially studies that focus on embryo factors that are predictive of success in IVF. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4063157 Tue, 12 Oct 2010 23:00:00 +0100 4063157 http://www.medworm.com/index.php?rid=4063156&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F6%2F568%3Frss%3D1 CONCLUSIONS LUNA does not result in improved chronic pelvic pain. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4063156 Tue, 12 Oct 2010 23:00:00 +0100 4063156 http://www.medworm.com/index.php?rid=4063155&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F6%2F561%3Frss%3D1 Systematic reviews and accompanying meta-analyses are the cornerstones of evidence-based medicine. Systematic reviews summarize clinical evidence; meta-analyses provide summary estimates of the treatment effect or the diagnostic test accuracy. Although deemed to provide the highest level of evidence, their clinical value is limited as they can only summarize aggregated data. In these meta-analyses the true variability of the treatment effects cannot be explored to the desired extent, because the meta-analyses cannot distinguish between patients with different clinical profiles. Systematic reviews and meta-analyses based on individual patient data (IPD), described as the ‘gold standard’ for systematic reviews are a promising approach that might overcome these limitations. IPD me... Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=4063155 Tue, 12 Oct 2010 23:00:00 +0100 4063155 http://www.medworm.com/index.php?rid=3847099&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F5%2F559-a%3Frss%3D1 (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3847099 Mon, 09 Aug 2010 16:09:03 +0100 3847099 http://www.medworm.com/index.php?rid=3847098&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F5%2F559%3Frss%3D1 (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3847098 Mon, 09 Aug 2010 16:09:03 +0100 3847098 http://www.medworm.com/index.php?rid=3847097&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F5%2F543%3Frss%3D1 CONCLUSIONS ARKO mouse models provide valuable tools to unravel novel roles of AR-mediated actions in male and female reproductive function, and new insights into the role of androgens in human reproductive function. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3847097 Mon, 09 Aug 2010 16:09:03 +0100 3847097 http://www.medworm.com/index.php?rid=3847096&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F5%2F525%3Frss%3D1 CONCLUSIONS AZFc is one of the most genetically dynamic regions in the human genome. This property may serve as counter against the genetic degeneracy associated with the lack of a meiotic partner. However, such strategy comes at a price: some rearrangements represent a risk factor or a de-facto causative agent of spermatogenic disruption. Interestingly, this precarious balance is modulated, among other yet unknown factors, by the evolutionary history of the Y chromosome. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3847096 Mon, 09 Aug 2010 16:09:03 +0100 3847096 http://www.medworm.com/index.php?rid=3847095&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F5%2F510%3Frss%3D1 CONCLUSIONS Cells and their signaling and regulatory molecules have been implicated in the immunological alterations found in the placental microenvironment of patients who develop pre-eclampsia. One of the main differences found in pre-eclampsia is a shift toward Th1 responses and the production of IFN-. The origin of IFN- is not clearly identified and could be the uterine natural killer cells, the placental dendritic cells modulating Th responses, alterations in synthesis of or response to regulatory molecules, or changes in the function of regulatory T cells in pregnancy. Aberrant immune responses promoting pre-eclampsia may also be due to an altered fetal allorecognition or to inflammatory triggers. Understanding the immunological basis for pre-eclampsia will expand knowledge regarding... Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3847095 Mon, 09 Aug 2010 16:09:02 +0100 3847095 http://www.medworm.com/index.php?rid=3847094&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F5%2F488%3Frss%3D1 CONCLUSIONS Prevention of the transmission of mtDNA disease from one generation to the next is still restricted by our lack of understanding as to how to ensure that a donor karyoplast transferred to an enucleated oocyte is free of accompanying mutant mtDNA. Techniques still need to be developed if stem cells are to be used to treat mtDNA disease in those patients already suffering from the phenotype. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3847094 Mon, 09 Aug 2010 16:09:02 +0100 3847094 http://www.medworm.com/index.php?rid=3847093&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F5%2F467%3Frss%3D1 CONCLUSIONS Fertility patients have ‘human needs’ besides their need for medical care. Evidence on PCRM is available but significant methodological limitations call for the development and validation of a European questionnaire. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3847093 Mon, 09 Aug 2010 16:09:02 +0100 3847093 http://www.medworm.com/index.php?rid=3847092&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F5%2F459%3Frss%3D1 CONCLUSION Prophylactic treatment with the dopamine agonist, cabergoline, reduces the incidence, but not the severity of OHSS, without compromising pregnancy outcomes. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3847092 Mon, 09 Aug 2010 16:09:02 +0100 3847092 http://www.medworm.com/index.php?rid=3631246&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F4%2F445%3Frss%3D1 CONCLUSIONS Associations between economic contraction and birthweight, neonatal mortality and the secondary sex ratio remain speculative. Consensus on methodology is needed to compare findings across studies. Further research on economic contraction and the secondary sex ratio, as well as individual-level birthweight and length of gestation, is warranted. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3631246 Fri, 04 Jun 2010 15:36:23 +0100 3631246 http://www.medworm.com/index.php?rid=3631245&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F4%2F432%3Frss%3D1 CONCLUSIONS Current evidence supports the hypothesis that tubal ectopic pregnancy is caused by a combination of retention of the embryo within the Fallopian tube due to impaired embryo-tubal transport and alterations in the tubal environment allowing early implantation to occur. Future studies are needed that address the functional consequences of infection and smoking on Fallopian tube physiology. A greater understanding of the aetiology of tubal ectopic pregnancy is critical for the development of improved preventative measures, the advancement of diagnostic screening methods and the development of novel treatments. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3631245 Fri, 04 Jun 2010 15:36:23 +0100 3631245 http://www.medworm.com/index.php?rid=3631244&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F4%2F415%3Frss%3D1 In the first trimester the extravillous cytotrophoblast cells occlude the uterine spiral arterioles creating a low oxygen environment early in pregnancy, which is essential for pregnancy success. Paradoxically, shallow trophoblast invasion and defective vascular remodelling of the uterine spiral arteries in the first trimester may result in impaired placental perfusion and chronic placental ischemia and hypoxia later in gestation leading to adverse pregnancy outcomes. The hypoxia inducible factors (HIFs) are key mediators of the response to low oxygen. We aimed to elucidate mechanisms of regulation of HIFs and the role these may play in the control of placental differentiation, growth and function in both normal and pathological pregnancies. The Pubmed database was consulted for identifica... Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3631244 Fri, 04 Jun 2010 15:36:23 +0100 3631244 http://www.medworm.com/index.php?rid=3631243&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F4%2F395%3Frss%3D1 CONCLUSIONS Experiments on ovarian tissue from non-human primate models and from consenting fertile and infertile patients benefit from a multidisciplinary approach. The new discipline of oncofertility requires professionalization, multidisciplinarity and mobilization of funding for basic and translational research. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3631243 Fri, 04 Jun 2010 15:36:23 +0100 3631243 http://www.medworm.com/index.php?rid=3631242&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F4%2F378%3Frss%3D1 CONCLUSIONS Identifying teratogenic mechanisms may not only be relevant for etiologic and post-marketing research, but may also have implications for drug development and prescribing behavior for women of reproductive age, especially since combinations of seemingly unrelated prescription and over the counter medications may utilize similar teratogenic mechanisms with a resultant increased risk of birth defects. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3631242 Fri, 04 Jun 2010 15:36:23 +0100 3631242 http://www.medworm.com/index.php?rid=3631241&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F4%2F364%3Frss%3D1 CONCLUSION A number of genetic variants have been discovered in association with ANM, although the overall results have been rather disappointing. We have described possible new strategies for future genetic studies to identify more genetic loci involved in the variation in menopausal age. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3631241 Fri, 04 Jun 2010 15:36:23 +0100 3631241 http://www.medworm.com/index.php?rid=3631240&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F4%2F347%3Frss%3D1 CONCLUSIONS Women with PCOS had an elevated prevalence of IGT, DM2 and metabolic syndrome in both BMI and non-BMI-matched studies. Few studies have determined IGT/DM2 or metabolic syndrome incidence in women with and without PCOS and further research is required. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3631240 Fri, 04 Jun 2010 15:36:23 +0100 3631240 http://www.medworm.com/index.php?rid=3439382&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F3%2F329%3Frss%3D1 CONCLUSION Much research on UTx has been performed in appropriate animal models. Several aspects of the procedure have been optimized but some remain to be solved. It is predicted that the research will soon reach a stage that could merit introduction of human UTx as an experimental procedure. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3439382 Mon, 05 Apr 2010 15:38:05 +0100 3439382 http://www.medworm.com/index.php?rid=3439381&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F3%2F312%3Frss%3D1 CONCLUSION While additional evidence is required to define optimal conditions for ITT cryopreservation with a view to transplantation or IVM, the putative indications for such techniques, as well as their limitations according to disease, are outlined. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3439381 Mon, 05 Apr 2010 15:38:05 +0100 3439381 http://www.medworm.com/index.php?rid=3439380&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F3%2F293%3Frss%3D1 CONCLUSIONS This systematic review with meta-analysis has not found evidence of an association between increased BMI and semen parameters. The main limitation of this review is that data from most studies could not be aggregated for meta-analysis. Population-based studies with larger sample sizes and longitudinal studies are required. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3439380 Mon, 05 Apr 2010 15:38:05 +0100 3439380 http://www.medworm.com/index.php?rid=3439379&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F3%2F276%3Frss%3D1 CONCLUSIONS The prevalence of obesity belies the plethora of endocrine signals in place to ensure energy homeostasis. However, satiety signals appear to be counteracted by hedonic signals derived from highly palatable foods typical of today's diet. A better understanding of the interaction between homeostatic and hedonic signals is needed to devise effective strategies for dealing with obesity. Menstrual cycle dependent changes in brain responses to food cues may provide insight into the normal physiological control of ingestive behavior as well as dysfunctional regulation associated with disordered eating. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3439379 Mon, 05 Apr 2010 15:38:05 +0100 3439379 http://www.medworm.com/index.php?rid=3439378&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F3%2F255%3Frss%3D1 CONCLUSIONS Maternal obesity requires the development of effective interventions to improve pregnancy outcome. Strategies that incorporate a detailed understanding of the maternal metabolic environment and its consequences for the health of the mother and the growth of the child are likely to identify the best approach. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3439378 Mon, 05 Apr 2010 15:38:05 +0100 3439378 http://www.medworm.com/index.php?rid=3439377&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F3%2F246%3Frss%3D1 CONCLUSIONS Overweight and obese subfertile women have a reduced probability of successful fertility treatment and their pregnancies are associated with more complications and higher costs. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3439377 Mon, 05 Apr 2010 15:38:05 +0100 3439377 http://www.medworm.com/index.php?rid=3439376&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F3%2F231%3Frss%3D1 CONCLUSIONS The data represent sound reference distributions of semen characteristics of fertile men in a number of countries. They provide an appropriate tool in conjunction with clinical data to evaluate a patient's semen quality and prospects for fertility. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3439376 Mon, 05 Apr 2010 15:38:05 +0100 3439376 http://www.medworm.com/index.php?rid=3439375&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F3%2F229%3Frss%3D1 (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3439375 Mon, 05 Apr 2010 15:38:05 +0100 3439375 http://www.medworm.com/index.php?rid=3237795&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F2%2F227%3Frss%3D1 (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3237795 Wed, 03 Feb 2010 16:32:25 +0100 3237795 http://www.medworm.com/index.php?rid=3237794&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F2%2F225%3Frss%3D1 (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3237794 Wed, 03 Feb 2010 16:32:25 +0100 3237794 http://www.medworm.com/index.php?rid=3237793&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F2%2F205%3Frss%3D1 CONCLUSION With the increased rate of genetically modified mouse production, the generation of mouse models with unexpected male infertility is increasing. This manuscript will help to ensure that the maximum amount of information is obtained from each mouse model and, by extension, will facilitate the knowledge of both normal fertility processes and the causes of human infertility. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3237793 Wed, 03 Feb 2010 16:32:25 +0100 3237793 http://www.medworm.com/index.php?rid=3237792&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F2%2F189%3Frss%3D1 CONCLUSION The risk of developing late complications after chlamydia lower genital tract infection appears low. High quality RCTs dealing with the transition from cervicitis to infertility are needed to broaden the evidence. In screening programmes, chlamydia antibody testing, as an intermediate marker for potential adverse sequelae, might enable more precise estimates. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3237792 Wed, 03 Feb 2010 16:32:25 +0100 3237792 http://www.medworm.com/index.php?rid=3237791&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F2%2F177%3Frss%3D1 CONCLUSION Gonads in males seem less affected than in females who exhibit hypergonadotropic hypoestrogenic subfertility. FSH can be elevated in infancy, and ovarian histology sometimes shows the presence of normal primordial follicles with absence of intermediate and Graafian follicles. These findings are similar to other genetic diseases primarily affecting the ovary. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3237791 Wed, 03 Feb 2010 16:32:25 +0100 3237791 http://www.medworm.com/index.php?rid=3237790&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F2%2F166%3Frss%3D1 CONCLUSIONS Early preimplantation embryos are particularly sensitive to increased osmolarity, and require the importation of glycine to regulate their cell volumes using a mechanism unique to early embryos. Cell volume regulation first appears when ovulation is triggered, oocyte zona pellucida adhesion is released, and glycine transport is activated. The requirement for supporting these physiological functions in oocytes and embryos should be taken into account when developing and improving systems for in vitro oocyte maturation and embryo culture. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3237790 Wed, 03 Feb 2010 16:32:25 +0100 3237790 http://www.medworm.com/index.php?rid=3237789&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F2%2F142%3Frss%3D1 CONCLUSIONS miRNAs appear to be potent regulators of gene expression in endometriosis and its associated reproductive disorders, raising the prospect of using miRNAs as biomarkers and therapeutic tools in endometriosis. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3237789 Wed, 03 Feb 2010 16:32:25 +0100 3237789 http://www.medworm.com/index.php?rid=3237788&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F2%2F131%3Frss%3D1 CONCLUSION Clinicians and patients should fully consider the relative risks and benefits of oophorectomy on an individual basis prior to surgery. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3237788 Wed, 03 Feb 2010 16:32:25 +0100 3237788 http://www.medworm.com/index.php?rid=3237787&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F2%2F113%3Frss%3D1 CONCLUSIONS As AMH may permit the identification of both the extremes of ovarian stimulation, a possible role for its measurement may be in the individualization of treatment strategies in order to reduce the clinical risk of ART along with optimized treatment burden. It is fundamental to clarify the cost/benefit of its use in ovarian reserve testing. Regarding the role of AMH in the evaluation of infertile men, AMH as single marker of spermatogenesis does not seem to reach a satisfactory clinical utility. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3237787 Wed, 03 Feb 2010 16:32:25 +0100 3237787 http://www.medworm.com/index.php?rid=3081219&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F1%2F111%3Frss%3D1 (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3081219 Fri, 11 Dec 2009 15:56:31 +0100 3081219 http://www.medworm.com/index.php?rid=3081218&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F1%2F110%3Frss%3D1 (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3081218 Fri, 11 Dec 2009 15:56:31 +0100 3081218 http://www.medworm.com/index.php?rid=3081217&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F1%2F109%3Frss%3D1 (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3081217 Fri, 11 Dec 2009 15:56:31 +0100 3081217 http://www.medworm.com/index.php?rid=3081216&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F1%2F108%3Frss%3D1 (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3081216 Fri, 11 Dec 2009 15:56:31 +0100 3081216 http://www.medworm.com/index.php?rid=3081215&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F1%2F96%3Frss%3D1 CONCLUSIONS Technological advances in the field of reproductive biology have enabled couples considered infertile to conceive and have healthy babies, causing a revolution in culture and customs. Today the independence of sex and reproduction is established and in the future human reproduction may move even further away from the sexual act, an option definitely unacceptable to some ethicists. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3081215 Fri, 11 Dec 2009 15:56:31 +0100 3081215 http://www.medworm.com/index.php?rid=3081214&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F1%2F80%3Frss%3D1 CONCLUSION Although human studies are scarce, and conclusive evidence is provided solely for periconceptional folate and prevention of neural tube defects (NTDs), the overall data indicate that micronutrients may affects fertility, embryogenesis and placentation, and the prophylactic use of some micronutrients may be useful in preventing several adverse pregnancy outcomes. Efforts to increase awareness of a healthy diet should be strengthened not only throughout pregnancy but also before. However, further researches in humans are necessary to optimise periconceptional micronutrient requirements. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3081214 Fri, 11 Dec 2009 15:56:31 +0100 3081214 http://www.medworm.com/index.php?rid=3081213&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F1%2F65%3Frss%3D1 CONCLUSION Although higher maternal age can be an indication for intensive prenatal diagnosis, including invasive diagnostics, consideration of the available evidence suggests that paternal age itself, however, provides no rationale for invasive procedures. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3081213 Fri, 11 Dec 2009 15:56:31 +0100 3081213 http://www.medworm.com/index.php?rid=3081212&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F1%2F51%3Frss%3D1 CONCLUSION Overall, the mFG scoring method is a useful visual instrument for assessing excess terminal hair growth, and the presence of hirsutism, in women. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3081212 Fri, 11 Dec 2009 15:56:31 +0100 3081212 http://www.medworm.com/index.php?rid=3081211&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F1%2F39%3Frss%3D1 CONCLUSIONS The identification of an autosomal mutation in the inhibin subunit gene that is significantly linked to POF in certain ethnic populations highlights the role of inhibin in the regulation of ovarian biology and fertility. Although the reduction of inhibin B bioactivity by the INHA G769A mutation is clearly not the only cause, evidence suggests that this change may serve as a susceptibility factor, increasing the likelihood of POF. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3081211 Fri, 11 Dec 2009 15:56:31 +0100 3081211 http://www.medworm.com/index.php?rid=3081210&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F1%2F20%3Frss%3D1 CONCLUSIONS HDL contributes to intra-follicular cholesterol homeostasis which appears to be important for successful oocyte and embryo development. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3081210 Fri, 11 Dec 2009 15:56:30 +0100 3081210 http://www.medworm.com/index.php?rid=3081209&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F1%2F12%3Frss%3D1 CONCLUSIONS Although there were no statistical differences, the study groups were small and heterogenic, with a number of potential biases. We therefore recommend a standardized methodology of follow-up studies after ART, with well-defined groups of ICSI with ejaculated sperm, ICSI with epididymal sperm and ICSI with testicular sperm, and a control group of naturally conceived children. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3081209 Fri, 11 Dec 2009 15:56:30 +0100 3081209 http://www.medworm.com/index.php?rid=3081208&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F16%2F1%2F1%3Frss%3D1 CONCLUSIONS Scarce evidence on the effectiveness of hysteroscopic surgery in subfertile women with polyps, fibroids, septate uterus or intrauterine adhesions indicates a potential benefit. More randomized controlled trials are needed before widespread use of hysteroscopic surgery in the general subfertile population can be justified. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=3081208 Fri, 11 Dec 2009 15:56:30 +0100 3081208 http://www.medworm.com/index.php?rid=2874079&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F15%2F6%2F667%3Frss%3D1 CONCLUSIONS Future studies should include measures of executive function and should address pressing clinical questions; including what formulation of combination hormone therapy is cognitively neutral/beneficial, yet effective in treating hot flashes in the early post-menopause. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=2874079 Thu, 08 Oct 2009 15:25:19 +0100 2874079 http://www.medworm.com/index.php?rid=2874078&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F15%2F6%2F649%3Frss%3D1 CONCLUSION Additional evidence is required to define optimal conditions for ovarian tissue transplantation. Alternatives such as whole ovary or isolated follicles transplantations require further investigation but are likely to be successful in humans in the future. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=2874078 Thu, 08 Oct 2009 15:25:19 +0100 2874078 http://www.medworm.com/index.php?rid=2874077&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F15%2F6%2F639%3Frss%3D1 CONCLUSIONS CP and congenital anomalies share a common pathogenic mechanism attributable to MZ twinning. These abnormalities in singletons are coincident with very early loss of one conceptus. The quantitative contribution of monozygosity and monochorionicity to the genesis of CP and congenital anomalies needs to be made. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=2874077 Thu, 08 Oct 2009 15:25:19 +0100 2874077 http://www.medworm.com/index.php?rid=2874076&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F15%2F6%2F623%3Frss%3D1 CONCLUSIONS It can be concluded that, so far, the mutation analysis of X-linked genes in humans, presumed to be crucial for spermatogenesis or sperm quality, has been disappointing. Other approaches to learn more about male infertility are necessary. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=2874076 Thu, 08 Oct 2009 15:25:18 +0100 2874076 http://www.medworm.com/index.php?rid=2874075&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F15%2F6%2F613%3Frss%3D1 CONCLUSIONS The present meta-analysis provides evidence that GH addition increases the probability of clinical pregnancy and live birth in poor responders undergoing ovarian stimulation with GnRH analogues and gonadotrophins for IVF. However, the total number of patients analyzed is small and thus further RCTs are warranted to prove or disprove this finding. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=2874075 Thu, 08 Oct 2009 15:25:18 +0100 2874075 http://www.medworm.com/index.php?rid=2874074&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F15%2F6%2F599%3Frss%3D1 CONCLUSIONS Women should be advised to continue with a contraceptive method until they have reached the menopause with its natural state of sterility. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=2874074 Thu, 08 Oct 2009 15:25:18 +0100 2874074 http://www.medworm.com/index.php?rid=2693754&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F15%2F5%2F587%3Frss%3D1 CONCLUSIONS The existing literature demonstrates the need for and the limits of current counselling. Future research should target the means to facilitate the decision-making process for patients and health professionals. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=2693754 Tue, 11 Aug 2009 23:00:00 +0100 2693754 http://www.medworm.com/index.php?rid=2693753&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F15%2F5%2F573%3Frss%3D1 CONCLUSIONS Aging of oocytes is characterized by a sequence of molecular processes that deteriorate during aging and negatively impact fertilization and development. However, oocyte aging can be delayed or reversed by various treatments to increase success rates and produce increased numbers of healthy embryos, preventing failures or abnormalities that are frequently associated with ART using aged oocytes. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=2693753 Tue, 11 Aug 2009 23:00:00 +0100 2693753 http://www.medworm.com/index.php?rid=2693752&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F15%2F5%2F553%3Frss%3D1 CONCLUSIONS Mitochondria-based events regulate different aspects of reproductive function, but these are not uniform throughout the several systems reviewed. Low mitochondrial activity seems a feature of ‘stemness’, being described in spermatogonia, early embryo, inner cell mass cells and embryonic stem cells. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=2693752 Tue, 11 Aug 2009 23:00:00 +0100 2693752 http://www.medworm.com/index.php?rid=2693751&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F15%2F5%2F537%3Frss%3D1 CONCLUSIONS Currently, there are three models with good predictive performance. These models can be used reliably as a guide for making decisions about fertility treatment, in patients similar to the development population. The effects of using these models in patient care have to be further investigated. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=2693751 Tue, 11 Aug 2009 23:00:00 +0100 2693751 http://www.medworm.com/index.php?rid=2693750&cid=s_32400_29_f&fid=32400&url=http%3A%2F%2Fhumupd.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F15%2F5%2F517%3Frss%3D1 CONCLUSIONS The potency and wide-ranging involvement of Treg cells in immune homeostasis and disease pathology indicates the considerable potential of these cells as therapeutic agents, raising the prospect of their utility in novel treatments for reproductive pathologies. (Source: Human Reproduction Update) Human Reproduction Update journals http://www.medworm.com/rss/comments.php?id=2693750 Tue, 11 Aug 2009 23:00:00 +0100 2693750