MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Immunity' source. Wed, 08 Feb 2012 06:42:51 +0100 http://www.medworm.com/index.php?rid=5659214&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2812%2900039-8 Melissa A. Kinnebrew, Charlie G. Buffie, Gretchen E. Diehl, Lauren A. Zenewicz, Ingrid Leiner, Tobias M. Hohl, Richard A. Flavell, Dan R. Littman, Eric G. Pamer. Microbial penetration of the intestinal epithelial barrier triggers inflammatory responses that include induction of the bactericidal C-type lectin RegIIIγ. Systemic administration of flagellin, a.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5659214 Thu, 02 Feb 2012 00:00:00 +0100 5659214 http://www.medworm.com/index.php?rid=5659213&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2812%2900014-3 In this study, we determined that Myd88-deficient mice are susceptible to .... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5659213 Thu, 02 Feb 2012 00:00:00 +0100 5659213 http://www.medworm.com/index.php?rid=5607648&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2812%2900005-2 Scott M. Gordon, Julie Chaix, Levi J. Rupp, Junmin Wu, Sharline Madera, Joseph C. Sun, Tullia Lindsten, Steven L. Reiner. Natural killer (NK) cells play critical roles defending against tumors and pathogens. We show that mice lacking both transcription factors Eomesodermin (Eomes) and T-bet failed to develop NK cells.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5607648 Thu, 19 Jan 2012 00:00:00 +0100 5607648 http://www.medworm.com/index.php?rid=5607647&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2812%2900004-0 Evan W. Newell, Natalia Sigal, Sean C. Bendall, Garry P. Nolan, Mark M. Davis. Cytotoxic CD8+ T lymphocytes directly kill infected or aberrant cells and secrete proinflammatory cytokines. By using metal-labeled probes and mass spectrometric analysis (cytometry by .... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5607647 Thu, 19 Jan 2012 00:00:00 +0100 5607647 http://www.medworm.com/index.php?rid=5607646&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2812%2900002-7 Dominikus Strasser, Konstantin Neumann, Hanna Bergmann, Mohlopheni J. Marakalala, Reto Guler, Anna Rojowska, Karl-Peter Hopfner, Frank Brombacher, Henning Urlaub, Gottfried Baier, Gordon D. Brown, Michael Leitges, Jürgen Ruland. C-type lectin receptors (CLRs) that couple with the kinase Syk are major pattern recognition receptors for the activation of innate immunity and host defense. CLRs recognize fungi and other forms .... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5607646 Thu, 19 Jan 2012 00:00:00 +0100 5607646 http://www.medworm.com/index.php?rid=5580507&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900548-6 Mary A. Markiewicz, Erica L. Wise, Zachary S. Buchwald, Amelia K. Pinto, Biljana Zafirova, Bojan Polic, Andrey S. Shaw. The mechanisms by which cytotoxic T lymphocytes (CTLs) enter and are retained in nonlymphoid tissue are not well characterized. With a transgenic mouse expressing the NKG2D ligand retinoic acid ea.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5580507 Thu, 12 Jan 2012 00:00:00 +0100 5580507 http://www.medworm.com/index.php?rid=5580506&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900547-4 Xiaohu Wang, Yibing Zhang, Xuexian O. Yang, Roza I. Nurieva, Seon Hee Chang, Sandra S. Ojeda, Hong S. Kang, Kimberly S. Schluns, Jianfang Gui, Anton M. Jetten, Chen Dong. T helper 17 (Th17) cells specifically transcribe the Il17 and Il17f genes, which are localized in the same chromosome region, but the underlying mechanism is unclear. Here, we report.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5580506 Thu, 12 Jan 2012 00:00:00 +0100 5580506 http://www.medworm.com/index.php?rid=5571722&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900546-2 Adebusola Alagbala Ajibade, Qinfu Wang, Jun Cui, Jia Zou, Xiaojun Xia, Mingjun Wang, Yanzheng Tong, Wei Hui, Dou Liu, Bing Su, Helen Y. Wang, Rong-Fu Wang. Stringent control of NF-κB and mitogen-activated protein kinase (MAPK) signaling is critical during innate immune responses. TGF-β activated kinase-1 (TAK1) is essential for NF-κB activation in T .... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5571722 Thu, 05 Jan 2012 00:00:00 +0100 5571722 http://www.medworm.com/index.php?rid=5551774&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900520-6 Anastasia N. Tikhonova, François Van Laethem, Ken-ichi Hanada, Jinghua Lu, Leonid A. Pobezinsky, Changwan Hong, Terry I. Guinter, Susanna K. Jeurling, Günter Bernhardt, Jung-Hyun Park, James C. Yang, Peter D. Sun, Alfred Singer. Major histocompatibility complex (MHC) restriction is the cardinal feature of T cell antigen recognition and is thought to be intrinsic to αβ T cell receptor (TCR) structure because of germline-en.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5551774 Thu, 29 Dec 2011 00:00:00 +0100 5551774 http://www.medworm.com/index.php?rid=5551773&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900518-8 Gerritje J.W. van der Windt, Bart Everts, Chih-Hao Chang, Jonathan D. Curtis, Tori C. Freitas, Eyal Amiel, Edward J. Pearce, Erika L. Pearce. CD8+ T cells undergo major metabolic changes upon activation, but how metabolism influences the establishment of long-lived memory T cells after infection remains a key question. We hav.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5551773 Thu, 29 Dec 2011 00:00:00 +0100 5551773 http://www.medworm.com/index.php?rid=5514876&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900505-X Ju Qiu, Jennifer J. Heller, Xiaohuan Guo, Zong-ming E. Chen, Kamonwan Fish, Yang-Xin Fu, Liang Zhou. Innate lymphoid cells (ILCs) expressing the nuclear receptor RORγt are essential for gut immunity presumably through production of interleukin-22 (IL-22). The molecular mechanism underlying the de.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5514876 Thu, 15 Dec 2011 00:00:00 +0100 5514876 http://www.medworm.com/index.php?rid=5514875&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900504-8 We report that Th17 cells, despite displ.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5514875 Thu, 15 Dec 2011 00:00:00 +0100 5514875 http://www.medworm.com/index.php?rid=5514874&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900503-6 Anneli Peters, Lisa A. Pitcher, Jenna M. Sullivan, Meike Mitsdoerffer, Sophie E. Acton, Bettina Franz, Kai Wucherpfennig, Shannon Turley, Michael C. Carroll, Raymond A. Sobel, Estelle Bettelli, Vijay K. Kuchroo. Ectopic lymphoid follicles are hallmarks of chronic autoimmune inflammatory diseases such as multiple sclerosis (MS), rheumatoid arthritis, Sjögren's syndrome, and myasthenia gravis. However, the .... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5514874 Thu, 15 Dec 2011 00:00:00 +0100 5514874 http://www.medworm.com/index.php?rid=5514873&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900502-4 Hideaki Takagi, Tomohiro Fukaya, Kawori Eizumi, Yumiko Sato, Kaori Sato, Azusa Shibazaki, Haruna Otsuka, Atsushi Hijikata, Takashi Watanabe, Osamu Ohara, Tsuneyasu Kaisho, Bernard Malissen, Katsuaki Sato. Plasmacytoid dendritic cells (pDCs) are characterized as type I interferon-producing cells that engage endosomal toll-like receptors (TLRs) and exclusively express sialic acid binding Ig-like lect.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5514873 Thu, 15 Dec 2011 00:00:00 +0100 5514873 http://www.medworm.com/index.php?rid=5486159&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900501-2 Xiao-Xia Jiang, Quan Nguyen, YuChia Chou, Tao Wang, Vijayalakshmi Nandakumar, Peter Yates, Lindsey Jones, Lifeng Wang, Haejung Won, Hye-Ra Lee, Jae U. Jung, Markus Müschen, Xue F. Huang, Si-Yi Chen. Epigenetic histone modifications play critical roles in the control of gene transcription. Recently, an increasing number of histone H2A deubiquitinases have been identified and characterized. How.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5486159 Thu, 08 Dec 2011 00:00:00 +0100 5486159 http://www.medworm.com/index.php?rid=5486158&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900498-5 Markus Biburger, Susanne Aschermann, Inessa Schwab, Anja Lux, Heike Albert, Heike Danzer, Melissa Woigk, Diana Dudziak, Falk Nimmerjahn. Immunoglobulin G (IgG) antibodies confer protection against pathogenic microorganisms, serve as therapeutics in tumor therapy, and are involved in destruction of healthy tissues during autoimmune .... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5486158 Thu, 08 Dec 2011 00:00:00 +0100 5486158 http://www.medworm.com/index.php?rid=5468196&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900454-7 Wei Hu, Ty Dale Troutman, Ramakrishna Edukulla, Chandrashekhar Pasare. Activation of pattern recognition receptors on dendritic cells (DCs) and macrophages leads to secretion of cytokines that control differentiation of CD4+ T cells. The current understand.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5468196 Thu, 01 Dec 2011 00:00:00 +0100 5468196 http://www.medworm.com/index.php?rid=5421205&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900457-2 Thorsten B. Feyerabend, Anne Weiser, Annette Tietz, Michael Stassen, Nicola Harris, Manfred Kopf, Peter Radermacher, Peter Möller, Christophe Benoist, Diane Mathis, Hans Jörg Fehling, Hans-Reimer Rodewald. Immunological functions of mast cells remain poorly understood. Studies in Kit mutant mice suggest key roles for mast cells in certain antibody- and T cell-mediated autoimmune diseases. How.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5421205 Thu, 17 Nov 2011 00:00:00 +0100 5421205 http://www.medworm.com/index.php?rid=5421204&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900455-9 Jarrett J. Adams, Samanthi Narayanan, Baoyu Liu, Michael E. Birnbaum, Andrew C. Kruse, Natalie A. Bowerman, Wei Chen, Aron M. Levin, Janet M. Connolly, Cheng Zhu, David M. Kranz, K. Christopher Garcia. T cell receptor (TCR) engagement of peptide-major histocompatibility complex (pMHC) is essential to adaptive immunity, but it is unknown whether TCR signaling responses are influenced by the bindi.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5421204 Thu, 17 Nov 2011 00:00:00 +0100 5421204 http://www.medworm.com/index.php?rid=5421203&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900417-1 Brian D. Stadinski, Peter Trenh, Rebecca L. Smith, Bianca Bautista, Priya G. Huseby, Guoqi Li, Lawrence J. Stern, Eric S. Huseby. A limited set of T cell receptor (TCR) variable (V) gene segments are used to create a repertoire of TCRs that recognize all major histocompatibility complex (MHC) ligands within a species. How in.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5421203 Thu, 17 Nov 2011 00:00:00 +0100 5421203 http://www.medworm.com/index.php?rid=5399789&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900456-0 Jae-Hoon Choi, Cheolho Cheong, Durga B. Dandamudi, Chae Gyu Park, Anthony Rodriguez, Saurabh Mehandru, Klara Velinzon, In-Hyuk Jung, Ji-Young Yoo, Goo Taeg Oh, Ralph M. Steinman. Early events in atherosclerosis occur in the aortic intima and involve monocytes that become macrophages. We looked for these cells in the steady state adult mouse aorta, and surprisingly, we foun.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5399789 Thu, 10 Nov 2011 00:00:00 +0100 5399789 http://www.medworm.com/index.php?rid=5399788&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900416-X Shannon K. O'Neill, Andrew Getahun, Stephen B. Gauld, Kevin T. Merrell, Idan Tamir, Mia J. Smith, Joseph M. Dal Porto, Quan-Zhen Li, John C. Cambier. Anergic B cells are characterized by impaired signaling and activation after aggregation of their antigen receptors (BCR). The molecular basis of this impairment is not understood. In studies repo.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5399788 Thu, 10 Nov 2011 00:00:00 +0100 5399788 http://www.medworm.com/index.php?rid=5399787&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900414-6 Maria L. Mouchess, Nicholas Arpaia, Gianne Souza, Roman Barbalat, Sarah E. Ewald, Laura Lau, Gregory M. Barton. Recognition of nucleic acids as a signature of infection by Toll-like receptors (TLRs) 7 and 9 exposes the host to potential self-recognition and autoimmunity. It has been proposed that intracellu.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5399787 Thu, 10 Nov 2011 00:00:00 +0100 5399787 http://www.medworm.com/index.php?rid=5399786&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900400-6 Jing W. Zhu, Kristin Doan, Jason Park, Angela H. Chau, Hong Zhang, Clifford A. Lowell, Arthur Weiss. Neutrophils, critical innate immune effectors, use bacterial-derived chemoattractant-induced G protein-coupled receptor (GPCR) signaling for their pursuit of bacteria. Tyrosine phosphorylation pat.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5399786 Thu, 10 Nov 2011 00:00:00 +0100 5399786 http://www.medworm.com/index.php?rid=5399790&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900408-0 Eilon Sherman, Valarie Barr, Suliana Manley, George Patterson, Lakshmi Balagopalan, Itoro Akpan, Carole K. Regan, Robert K. Merrill, Connie L. Sommers, Jennifer Lippincott-Schwartz, Lawrence E. Samelson. Receptor-regulated cellular signaling often is mediated by formation of transient, heterogeneous protein complexes of undefined structure. We used single and two-color photoactivated localization .... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5399790 Tue, 08 Nov 2011 00:00:00 +0100 5399790 http://www.medworm.com/index.php?rid=5334731&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900406-7 Heather D. Marshall, Anmol Chandele, Yong Woo Jung, Hailong Meng, Amanda C. Poholek, Ian A. Parish, Rachel Rutishauser, Weiguo Cui, Steven H. Kleinstein, Joe Craft, Susan M. Kaech. CD4+ T cells differentiate into multiple effector types, but it is unclear how they form memory T cells during infection in vivo. Profiling virus-specific CD4+ T cells reveal.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5334731 Thu, 20 Oct 2011 00:00:00 +0100 5334731 http://www.medworm.com/index.php?rid=5334730&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900405-5 Laurent Boyer, Lorin Magoc, Stephanie Dejardin, Michael Cappillino, Nicholas Paquette, Charlotte Hinault, Guillaume M. Charriere, W.K. Eddie Ip, Shannon Fracchia, Elizabeth Hennessy, Deniz Erturk-Hasdemir, Jean-Marc Reichhart, Neal Silverman, Adam Lacy-Hulbert, Lynda M. Stuart. Although infections with virulent pathogens often induce a strong inflammatory reaction, what drives the increased immune response to pathogens compared to nonpathogenic microbes is poorly underst.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5334730 Thu, 20 Oct 2011 00:00:00 +0100 5334730 http://www.medworm.com/index.php?rid=5334729&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900402-X Kristina T. Lu, Yuka Kanno, Jennifer L. Cannons, Robin Handon, Paul Bible, Abdel G. Elkahloun, Stacie M. Anderson, Lai Wei, Hongwei Sun, John J. O'Shea, Pamela L. Schwartzberg. Follicular T helper (Tfh) cells provide critical help to B cells for germinal center (GC) formation. Mutations affecting SLAM-associated protein (SAP) prevent GC formation because of defective T c.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5334729 Thu, 20 Oct 2011 00:00:00 +0100 5334729 http://www.medworm.com/index.php?rid=5334728&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900397-9 Marion Pepper, Antonio J. Pagán, Botond Z. Igyártó, Justin J. Taylor, Marc K. Jenkins. Listeria monocytogenes infection generates T helper 1 (Th1) effector memory cells and CC chemokine receptor 7 (CCR7)+ cells resembling central memory cells. We tracked endogenous.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5334728 Thu, 20 Oct 2011 00:00:00 +0100 5334728 http://www.medworm.com/index.php?rid=5334727&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900359-1 Kanako L. Lewis, Michele L. Caton, Milena Bogunovic, Melanie Greter, Lucja T. Grajkowska, Dennis Ng, Apostolos Klinakis, Israel F. Charo, Steffen Jung, Jennifer L. Gommerman, Ivaylo I. Ivanov, Kang Liu, Miriam Merad, Boris Reizis. Dendritic cells (DCs) in tissues and lymphoid organs comprise distinct functional subsets that differentiate in situ from circulating progenitors. Tissue-specific signals that regulate DC subset d.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5334727 Thu, 20 Oct 2011 00:00:00 +0100 5334727 http://www.medworm.com/index.php?rid=5313605&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900401-8 Marion C. Bonnet, Daniela Preukschat, Patrick-Simon Welz, Geert van Loo, Maria A. Ermolaeva, Wilhelm Bloch, Ingo Haase, Manolis Pasparakis. Epidermal keratinocytes provide an essential structural and immunological barrier forming the first line of defense against potentially pathogenic microorganisms. Mechanisms regulating barrier int.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5313605 Thu, 13 Oct 2011 00:00:00 +0100 5313605 http://www.medworm.com/index.php?rid=5313604&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900399-2 Claudia Ribeiro de Almeida, Ralph Stadhouders, Marjolein J.W. de Bruijn, Ingrid M. Bergen, Supat Thongjuea, Boris Lenhard, Wilfred van IJcken, Frank Grosveld, Niels Galjart, Eric Soler, Rudi W. Hendriks. Regulation of immunoglobulin (Ig) V(D)J gene rearrangement is dependent on higher-order chromatin organization. Here, we studied the in vivo function of the DNA-binding zinc-finger protein CTCF, w.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5313604 Thu, 13 Oct 2011 00:00:00 +0100 5313604 http://www.medworm.com/index.php?rid=5296280&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900398-0 Seon Hee Chang, Joseph M. Reynolds, Bhanu P. Pappu, Guangjie Chen, Gustavo J. Martinez, Chen Dong. Although several interleukin-17 (IL-17) family members and their receptors have been recently appreciated as important regulators in inflammatory diseases, the function of other IL-17 cytokines an.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5296280 Thu, 06 Oct 2011 00:00:00 +0100 5296280 http://www.medworm.com/index.php?rid=5296279&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900396-7 Alon Y. Hershko, Ryo Suzuki, Nicolas Charles, Damiana Alvarez-Errico, Jennifer L. Sargent, Arian Laurence, Juan Rivera. The incidence of chronic allergic dermatitis is rapidly increasing. Regulatory control of this disease has not been adequately explored. Here we report that mast cell-derived interleukin-2 (IL-2) .... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5296279 Thu, 06 Oct 2011 00:00:00 +0100 5296279 http://www.medworm.com/index.php?rid=5296278&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900306-2 Yihua Cai, Xiaoyan Shen, Chuanlin Ding, Chunjian Qi, Kejia Li, Xia Li, Venkatakrishna R. Jala, Huang-ge Zhang, Tian Wang, Jie Zheng, Jun Yan. Interleukin-23 (IL-23) and CD4+ T helper 17 (Th17) cells are thought to be critical in psoriasis pathogenesis. Here, we report that IL-23 predominantly stimulated dermal γδ T cells to p.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5296278 Thu, 06 Oct 2011 00:00:00 +0100 5296278 http://www.medworm.com/index.php?rid=5272876&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900369-4 Song Gao, Alexander von der Malsburg, Alexej Dick, Katja Faelber, Gunnar F. Schröder, Otto Haller, Georg Kochs, Oliver Daumke. Human myxovirus resistance protein 1 (MxA) is an interferon-induced dynamin-like GTPase that acts as a cell-autonomous host restriction factor against many viral pathogens including influenza viru.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5272876 Thu, 29 Sep 2011 00:00:00 +0100 5272876 http://www.medworm.com/index.php?rid=5272875&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900365-7 James P. Scott-Browne, Frances Crawford, Mary H. Young, John W. Kappler, Philippa Marrack, Laurent Gapin. αβ T cell receptors (TCRs) bind specifically to foreign antigens presented by major histocompatibility complex proteins (MHC) or MHC-like molecules. Accumulating evidence indicates that the germli.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5272875 Thu, 29 Sep 2011 00:00:00 +0100 5272875 http://www.medworm.com/index.php?rid=5224032&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900358-X Yunqi Wang, Maureen A. Su, Yisong Y. Wan. Forkhead Box P3 (Foxp3)-expressing regulatory T (Treg) cells are central to maintaining self-tolerance and immune homeostasis. How Treg cell function and Foxp3 expression are regulated is an impor.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5224032 Thu, 15 Sep 2011 00:00:00 +0100 5224032 http://www.medworm.com/index.php?rid=5207266&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900356-6 Rashmi Kumar, María Ferez, Mahima Swamy, Ignacio Arechaga, María Teresa Rejas, Jose M. Valpuesta, Wolfgang W.A. Schamel, Balbino Alarcon, Hisse M. van Santen. Although memory T cells respond more vigorously to stimulation and they are more sensitive to low doses of antigen than naive T cells, the molecular basis of this increased sensitivity remains unc.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5207266 Thu, 08 Sep 2011 00:00:00 +0100 5207266 http://www.medworm.com/index.php?rid=5207265&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900355-4 Shitao Li, Lingyan Wang, Michael Berman, Young-Yun Kong, Martin E. Dorf. To systematically investigate innate immune signaling networks regulating production of type I interferon, we analyzed protein complexes formed after microbial recognition. Fifty-eight baits were .... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5207265 Thu, 08 Sep 2011 00:00:00 +0100 5207265 http://www.medworm.com/index.php?rid=5207264&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900354-2 Elinore M. Mercer, Yin C. Lin, Christopher Benner, Suchit Jhunjhunwala, Janusz Dutkowski, Martha Flores, Mikael Sigvardsson, Trey Ideker, Christopher K. Glass, Cornelis Murre. Recent studies have documented genome-wide binding patterns of transcriptional regulators and their associated epigenetic marks in hematopoietic cell lineages. In order to determine how epigenetic.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5207264 Thu, 08 Sep 2011 00:00:00 +0100 5207264 http://www.medworm.com/index.php?rid=5142832&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900305-0 Erin E. West, Ben Youngblood, Wendy G. Tan, Hyun-Tak Jin, Koichi Araki, Gabriela Alexe, Bogumila T. Konieczny, Silvia Calpe, Gordon J. Freeman, Cox Terhorst, W. Nicholas Haining, Rafi Ahmed. To design successful vaccines for chronic diseases, an understanding of memory CD8+ T cell responses to persistent antigen restimulation is critical. However, most studies comparing mem.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5142832 Thu, 18 Aug 2011 00:00:00 +0100 5142832 http://www.medworm.com/index.php?rid=5119412&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900304-9 Kyla Omilusik, John J. Priatel, Xiaoxi Chen, Yiwen Teresa Wang, Hongjian Xu, Kyung Bok Choi, Rayshad Gopaul, Adam McIntyre-Smith, Hung-Sia Teh, Rusung Tan, N. Torben Bech-Hansen, Douglas Waterfield, David Fedida, Simon V. Hunt, Wilfred A. Jefferies. The transport of calcium ions (Ca2+) to the cytosol is essential for immunoreceptor signaling, regulating lymphocyte differentiation, activation, and effector function. Increases in cyt.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5119412 Thu, 11 Aug 2011 00:00:00 +0100 5119412 http://www.medworm.com/index.php?rid=5119411&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900302-5 Wei Cao, Yiqing Yang, Zhengyi Wang, Ailian Liu, Lei Fang, Fenglan Wu, Jian Hong, Yufang Shi, Stewart Leung, Chen Dong, Jingwu Z. Zhang. Neural progenitor cell (NPC) therapy is considered a promising treatment modality for multiple sclerosis (MS), potentially acting through neural repair. Here, we showed that intravenous administra.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5119411 Thu, 11 Aug 2011 00:00:00 +0100 5119411 http://www.medworm.com/index.php?rid=5119410&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900275-5 Emanuela Frittoli, Gianluca Matteoli, Andrea Palamidessi, Elisa Mazzini, Luigi Maddaluno, Andrea Disanza, Changsong Yang, Tatyana Svitkina, Maria Rescigno, Giorgio Scita. Dendritic cells (DCs) flexibly adapt to different microenvironments by using diverse migration strategies that are ultimately dependent on the dynamics and structural organization of the actin cyt.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5119410 Thu, 11 Aug 2011 00:00:00 +0100 5119410 http://www.medworm.com/index.php?rid=5096052&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900301-3 Shruti Sharma, Rosane B. DeOliveira, Parisa Kalantari, Peggy Parroche, Nadege Goutagny, Zhaozhao Jiang, Jennie Chan, Daniella C. Bartholomeu, Fanny Lauw, J. Perry Hall, Glen N. Barber, Ricardo T. Gazzinelli, Katherine A. Fitzgerald, Douglas T. Golenbock. Although Toll-like receptor 9 (TLR9) has been implicated in cytokine and type I interferon (IFN) production during malaria in humans and mice, the high AT content of the Plasmodium falciparum (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5096052 Thu, 04 Aug 2011 00:00:00 +0100 5096052 http://www.medworm.com/index.php?rid=5096051&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900300-1 David F. Steiner, Molly F. Thomas, Joyce K. Hu, Zhiyong Yang, Joshua E. Babiarz, Christopher D.C. Allen, Mehrdad Matloubian, Robert Blelloch, K. Mark Ansel. MicroRNA (miRNA)-deficient helper T cells exhibit abnormal IFN-γ production and decreased proliferation. However, the contributions of individual miRNAs to this phenotype remain poorly understood..... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5096051 Thu, 04 Aug 2011 00:00:00 +0100 5096051 http://www.medworm.com/index.php?rid=5096050&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900299-8 Colin Reardon, Matthias Lechmann, Anne Brüstle, Mélanie G. Gareau, Naomi Shuman, Dana Philpott, Steven F. Ziegler, Tak W. Mak. Thymic stromal lymphopoetin (TSLP) influences numerous immune functions, including those in the colonic mucosa. Here we report that TSLP-deficient (Tslp−/−) mice did not exhibit .... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5096050 Thu, 04 Aug 2011 00:00:00 +0100 5096050 http://www.medworm.com/index.php?rid=5096049&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900276-7 Maria-Isabel Yuseff, Anne Reversat, Danielle Lankar, Jheimmy Diaz, Isabelle Fanget, Paolo Pierobon, Violaine Randrian, Nathanael Larochette, Fulvia Vascotto, Chantal Desdouets, Bertrand Jauffred, Yohanns Bellaiche, Stéphane Gasman, François Darchen, Claire Desnos, Ana-Maria Lennon-Duménil. Engagement of the B cell receptor (BCR) by surface-tethered antigens (Ag) leads to formation of a synapse that promotes Ag uptake for presentation onto major histocompatibility complex class II (M.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5096049 Thu, 04 Aug 2011 00:00:00 +0100 5096049 http://www.medworm.com/index.php?rid=5096048&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900233-0 Nuria Martínez-Martín, Elena Fernández-Arenas, Saso Cemerski, Pilar Delgado, Martin Turner, John Heuser, Darrell J. Irvine, Bonnie Huang, Xosé R. Bustelo, Andrey Shaw, Balbino Alarcón. The immunological synapse (IS) serves a dual role for sustained T cell receptor (TCR) signaling and for TCR downregulation. TC21 (Rras2) is a RRas subfamily GTPase that constitutively assoc.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5096048 Thu, 04 Aug 2011 00:00:00 +0100 5096048 http://www.medworm.com/index.php?rid=5078300&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900267-6 Salil Garg, Mahak Sharma, Cindy Ung, Amit Tuli, Duarte C. Barral, David L. Hava, Natacha Veerapen, Gurdyal S. Besra, Nir Hacohen, Michael B. Brenner. Antigen presentation and microbial killing are critical arms of host defense that depend upon cargo trafficking into lysosomes. Yet, the molecular regulators of traffic into lysosomes are only par.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5078300 Thu, 28 Jul 2011 00:00:00 +0100 5078300 http://www.medworm.com/index.php?rid=5052057&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900237-8 Botond Z. Igyártó, Krystal Haley, Daniela Ortner, Aleh Bobr, Maryam Gerami-Nejad, Brian T. Edelson, Sandra M. Zurawski, Bernard Malissen, Gerard Zurawski, Judith Berman, Daniel H. Kaplan. Skin-resident dendritic cells (DCs) are well positioned to encounter cutaneous pathogens and are required for the initiation of adaptive immune responses. There are at least three subsets of skin .... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5052057 Thu, 21 Jul 2011 00:00:00 +0100 5052057 http://www.medworm.com/index.php?rid=5029682&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900266-4 Klaas P.J.M. van Gisbergen, Paul L. Klarenbeek, Natasja A.M. Kragten, Peter-Paul A. Unger, Marieke B.B. Nieuwenhuis, Felix M. Wensveen, Anja ten Brinke, Paul P. Tak, Eric Eldering, Martijn A. Nolte, Rene A.W. van Lier. CD70 and CD27 are costimulatory molecules that provide essential signals for the expansion and differentiation of CD8+ T cells. Here, we show that CD27-driven costimulation lowered the .... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5029682 Thu, 14 Jul 2011 00:00:00 +0100 5029682 http://www.medworm.com/index.php?rid=5029681&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900265-2 Moses K. Donkor, Abira Sarkar, Peter A. Savage, Ruth A. Franklin, Linda K. Johnson, Achim A. Jungbluth, James P. Allison, Ming O. Li. Tolerance induction in T cells takes place in most tumors and is thought to account for tumor evasion from immune eradication. Production of the cytokine TGF-β is implicated in immunosuppression, .... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5029681 Thu, 14 Jul 2011 00:00:00 +0100 5029681 http://www.medworm.com/index.php?rid=5009235&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900264-0 Gleb Turchinovich, Adrian C. Hayday. Murine T cell development begins with the generation of a unique Vγ5+Vδ1+ epidermal γδ T cell compartment and a unique, more broadly distributed Vγ6+Vδ1+ (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=5009235 Thu, 07 Jul 2011 00:00:00 +0100 5009235 http://www.medworm.com/index.php?rid=4985260&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900259-7 We examined the functio.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4985260 Thu, 30 Jun 2011 00:00:00 +0100 4985260 http://www.medworm.com/index.php?rid=4985259&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900236-6 Gonghua Huang, Yanyan Wang, Lewis Z. Shi, Thirumala-Devi Kanneganti, Hongbo Chi. Naive T cells respond to antigens by differentiating into effector and regulatory lineages. Whereas the roles of T cell-intrinsic pathways have been extensively studied, how T cell lineage choices.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4985259 Thu, 30 Jun 2011 00:00:00 +0100 4985259 http://www.medworm.com/index.php?rid=4985258&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900234-2 Mirjam Kool, Geert van Loo, Wim Waelput, Sofie De Prijck, Femke Muskens, Mozes Sze, Jens van Praet, Filipe Branco-Madeira, Sophie Janssens, Boris Reizis, Dirk Elewaut, Rudi Beyaert, Hamida Hammad, Bart N. Lambrecht. Dendritic cells (DCs) regulate both immunity and tolerance. Here we have shown that the ubiquitin editing enzyme A20 (Tnfaip3) determines the activation threshold of DCs, via control of can.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4985258 Thu, 30 Jun 2011 00:00:00 +0100 4985258 http://www.medworm.com/index.php?rid=4985257&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900225-1 Melissa Kane, Laure K. Case, Christine Wang, Leonid Yurkovetskiy, Stanislav Dikiy, Tatyana V. Golovkina. Innate immune sensors are required for induction of pathogen-specific immune responses. Retroviruses are notorious for their ability to evade immune defenses and establish long-term persistence in.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4985257 Thu, 30 Jun 2011 00:00:00 +0100 4985257 http://www.medworm.com/index.php?rid=4935743&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900220-2 Ryutaro Fukui, Shin-Ichiroh Saitoh, Atsuo Kanno, Masahiro Onji, Takuma Shibata, Akihiko Ito, Morikazu Onji, Mitsuru Matsumoto, Shizuo Akira, Nobuaki Yoshida, Kensuke Miyake. Toll-like receptor-7 (TLR7) and 9, innate immune sensors for microbial RNA or DNA, have been implicated in autoimmunity. Upon activation, TLR7 and 9 are transported from the endoplasmic reticulum .... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4935743 Thu, 16 Jun 2011 00:00:00 +0100 4935743 http://www.medworm.com/index.php?rid=4935742&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900180-4 Lei Yin, Eric Huseby, James Scott-Browne, Kira Rubtsova, Clamencia Pinilla, Frances Crawford, Philippa Marrack, Shaodong Dai, John W. Kappler. Major histocompatibility complex class I (MHCI) and MHCII proteins differ in structure and sequence. To understand how T cell receptors (TCRs) can use the same set of variable regions to bind both.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4935742 Thu, 16 Jun 2011 00:00:00 +0100 4935742 http://www.medworm.com/index.php?rid=4935741&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900178-6 Syed Raza Ali, Anjuli M. Timmer, Sameera Bilgrami, Eek Joong Park, Lars Eckmann, Victor Nizet, Michael Karin. Detection of microbial constituents by membrane associated and cytoplasmic pattern recognition receptors is the essence of innate immunity, leading to activation of protective host responses. Howe.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4935741 Thu, 16 Jun 2011 00:00:00 +0100 4935741 http://www.medworm.com/index.php?rid=4935740&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900140-3 Wenbin Xiao, Jun-ichi Kashiwakura, Hong Hong, Hiroki Yasudo, Tomoaki Ando, Mari Maeda-Yamamoto, Dianqing Wu, Yuko Kawakami, Toshiaki Kawakami. Mast cells are major effectors in high-affinity IgE receptor (FcɛRI)-dependent allergic reactions. Here we show that phospholipase C (PLC)-β3 is crucial for FcɛRI-mediated mast cell activation. (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4935740 Thu, 16 Jun 2011 00:00:00 +0100 4935740 http://www.medworm.com/index.php?rid=4935744&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900137-3 Amelia J. Brennan, Jenny Chia, Kylie A. Browne, Annette Ciccone, Sarah Ellis, Jamie A. Lopez, Olivia Susanto, Sandra Verschoor, Hideo Yagita, James C. Whisstock, Joseph A. Trapani, Ilia Voskoboinik. Cytotoxic lymphocyte-mediated apoptosis is dependent on the delivery of perforin to secretory granules and its ability to form calcium-dependent pores in the target cell after granule exocytosis. .... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4935744 Thu, 09 Jun 2011 00:00:00 +0100 4935744 http://www.medworm.com/index.php?rid=4894395&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900195-6 Masahiro Kitano, Saya Moriyama, Yoshikazu Ando, Masaki Hikida, Yasuo Mori, Tomohiro Kurosaki, Takaharu Okada. The transcription factor Bcl6 is essential for the development of germinal center (GC) B cells and follicular helper T (Tfh) cells. However, little is known about in vivo dynamics of Bcl6 protein .... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4894395 Thu, 02 Jun 2011 00:00:00 +0100 4894395 http://www.medworm.com/index.php?rid=4894394&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900194-4 Steven M. Kerfoot, Gur Yaari, Jaymin R. Patel, Kody L. Johnson, David G. Gonzalez, Steven H. Kleinstein, Ann M. Haberman. We identify the interfollicular (IF) zone as the site where germinal center B cell and T follicular helper (Tfh) cell differentiation initiates. For the first 2 days postimmunization, antigen-spec.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4894394 Thu, 02 Jun 2011 00:00:00 +0100 4894394 http://www.medworm.com/index.php?rid=4894393&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900185-3 Youn Soo Choi, Robin Kageyama, Danelle Eto, Tania C. Escobar, Robert J. Johnston, Laurel Monticelli, Christopher Lao, Shane Crotty. The nature of follicular helper CD4+ T (Tfh) cell differentiation remains controversial, including the minimal signals required for Tfh cell differentiation and the time at which Tfh ce.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4894393 Thu, 02 Jun 2011 00:00:00 +0100 4894393 http://www.medworm.com/index.php?rid=4842333&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900183-X Jackson G. Egen, Antonio Gigliotti Rothfuchs, Carl G. Feng, Marcus A. Horwitz, Alan Sher, Ronald N. Germain. Cell-mediated adaptive immunity is critical for host defense, but little is known about T cell behavior during delivery of effector function. Here we investigate relationships among antigen presen.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4842333 Thu, 19 May 2011 00:00:00 +0100 4842333 http://www.medworm.com/index.php?rid=4842332&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900182-8 Kenji Ichiyama, Takashi Sekiya, Naoko Inoue, Taiga Tamiya, Ikko Kashiwagi, Akihiro Kimura, Rimpei Morita, Go Muto, Takashi Shichita, Reiko Takahashi, Akihiko Yoshimura. Transforming growth factor-β (TGF-β) has been shown to be required for Th17 cell differentiation via Smad-independent mechanisms. The molecular mechanism underlying this pathway remains to be clar.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4842332 Thu, 19 May 2011 00:00:00 +0100 4842332 http://www.medworm.com/index.php?rid=4842331&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900181-6 Markus B. Geuking, Julia Cahenzli, Melissa A.E. Lawson, Derek C.K. Ng, Emma Slack, Siegfried Hapfelmeier, Kathy D. McCoy, Andrew J. Macpherson. Mammals harbor a dense commensal microbiota in the colon. Regulatory T (Treg) cells are known to limit microbe-triggered intestinal inflammation and the CD4+ T cell compartment is shape.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4842331 Thu, 19 May 2011 00:00:00 +0100 4842331 http://www.medworm.com/index.php?rid=4842330&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900176-2 Jae Jin Chae, Young-Hun Cho, Geun-Shik Lee, Jun Cheng, P. Paul Liu, Lionel Feigenbaum, Stephen I. Katz, Daniel L. Kastner. Missense mutations in the C-terminal B30.2 domain of pyrin cause familial Mediterranean fever (FMF), the most common Mendelian autoinflammatory disease. However, it remains controversial as to whe.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4842330 Thu, 19 May 2011 00:00:00 +0100 4842330 http://www.medworm.com/index.php?rid=4821386&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900177-4 Ganapati H. Mahabeleshwar, Daiji Kawanami, Nikunj Sharma, Yoichi Takami, Guangjin Zhou, Hong Shi, Lalitha Nayak, Darwin Jeyaraj, Robert Grealy, Mary White, Ross McManus, Thomas Ryan, Patrick Leahy, Zhiyong Lin, Saptarsi M. Haldar, G. Brandon Atkins, Hector R. Wong, Jerry B. Lingrel, Mukesh K. Jain. Precise control of myeloid cell activation is required for optimal host defense. However, this activation process must be under exquisite control to prevent uncontrolled inflammation. Herein, we i.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4821386 Thu, 12 May 2011 00:00:00 +0100 4821386 http://www.medworm.com/index.php?rid=4821385&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900175-0 Yun-Gi Kim, Nobuhiko Kamada, Michael H. Shaw, Neil Warner, Grace Y. Chen, Luigi Franchi, Gabriel Núñez. The intracellular sensor Nod2 is activated in response to bacteria, and the impairment of this response is linked to Crohn's disease. However, the function of Nod2 in host defense remains poorly u.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4821385 Thu, 12 May 2011 00:00:00 +0100 4821385 http://www.medworm.com/index.php?rid=4789953&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900174-9 Jeffrey C. Nolz, John T. Harty. Infection or vaccination confers heightened resistance to pathogen rechallenge because of quantitative and qualitative differences between naive and primary memory T cells. Herein, we show that se.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4789953 Thu, 05 May 2011 00:00:00 +0100 4789953 http://www.medworm.com/index.php?rid=4763255&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900123-3 Masanori Matsumoto, Yoko Fujii, Akemi Baba, Masaki Hikida, Tomohiro Kurosaki, Yoshihiro Baba. A chief Ca2+ entry pathway in immune cells is store-operated Ca2+ (SOC) influx, which is triggered by depletion of Ca2+ from the endoplasmic reticulum (ER). Howeve.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4763255 Thu, 28 Apr 2011 00:00:00 +0100 4763255 http://www.medworm.com/index.php?rid=4763254&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900121-X Sheng Yao, Yuwen Zhu, Gefeng Zhu, Mathew Augustine, Linghua Zheng, Diana J. Goode, Megan Broadwater, William Ruff, Sarah Flies, Haiying Xu, Dallas Flies, Liqun Luo, Shengdian Wang, Lieping Chen. CD28 and CTLA-4 are cell surface cosignaling molecules essential for the control of T cell activation upon the engagement of their ligands B7-1 and B7-2 from antigen-presenting cells. By employing.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4763254 Thu, 28 Apr 2011 00:00:00 +0100 4763254 http://www.medworm.com/index.php?rid=4715078&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900128-2 Etsushi Kuroda, Ken J. Ishii, Satoshi Uematsu, Keiichi Ohata, Cevayir Coban, Shizuo Akira, Kosuke Aritake, Yoshihiro Urade, Yasuo Morimoto. Particulates such as silica crystal (silica) and aluminum salts (alum) activate the inflammasome and induce the secretion of proinflammatory cytokines in macrophages. These particulates also induc.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4715078 Thu, 14 Apr 2011 00:00:00 +0100 4715078 http://www.medworm.com/index.php?rid=4715077&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900126-9 Tanya R. McKitrick, Christina C. Muscat, James D. Pierce, Deepta Bhattacharya, Anthony W. De Tomaso. Histocompatibility in the basal chordate Botryllus schlosseri is controlled by the polymorphisms of a single gene: the fuhc. A polymorphic candidate receptor (fester) appeared.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4715077 Thu, 14 Apr 2011 00:00:00 +0100 4715077 http://www.medworm.com/index.php?rid=4715076&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900125-7 John T. Chang, Maria L. Ciocca, Ichiko Kinjyo, Vikram R. Palanivel, Courtney E. McClurkin, Caitlin S. DeJong, Erin C. Mooney, Jiyeon S. Kim, Natalie C. Steinel, Jane Oliaro, Catherine C. Yin, Bogdan I. Florea, Herman S. Overkleeft, Leslie J. Berg, Sarah M. Russell, Gary A. Koretzky, Martha S. Jordan, Steven L. Reiner. Polarized segregation of proteins in T cells is thought to play a role in diverse cellular functions including signal transduction, migration, and directed secretion of cytokines. Persistence of t.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4715076 Thu, 14 Apr 2011 00:00:00 +0100 4715076 http://www.medworm.com/index.php?rid=4715075&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900124-5 Boyoun Park, Ludovico Buti, Sungwook Lee, Takashi Matsuwaki, Eric Spooner, Melanie M. Brinkmann, Masugi Nishihara, Hidde L. Ploegh. Toll-like receptor (TLR) signaling plays a critical role in innate and adaptive immune responses and must be tightly controlled. TLR4 uses LPS binding protein, MD-2, and CD14 as accessories to res.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4715075 Thu, 14 Apr 2011 00:00:00 +0100 4715075 http://www.medworm.com/index.php?rid=4685363&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900122-1 Mirjam Kool, Monique A.M. Willart, Menno van Nimwegen, Ingrid Bergen, Philippe Pouliot, J. Christian Virchow, Neil Rogers, Fabiola Osorio, Caetano Reis e Souza, Hamida Hammad, Bart N. Lambrecht. Although deposition of uric acid (UA) crystals is known as the cause of gout, it is unclear whether UA plays a role in other inflammatory diseases. We here have shown that UA is released in the ai.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4685363 Thu, 07 Apr 2011 00:00:00 +0100 4685363 http://www.medworm.com/index.php?rid=4664133&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900076-8 Hozefa S. Bandukwala, Yongqing Wu, Markus Feurer, Yongheng Chen, Bianca Barbosa, Srimoyee Ghosh, James C. Stroud, Christophe Benoist, Diane Mathis, Anjana Rao, Lin Chen. The transcription factor FOXP3 is essential for the suppressive function of regulatory T cells that are required for maintaining self-tolerance. We have solved the crystal structure of the FOXP3 f.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4664133 Thu, 31 Mar 2011 00:00:00 +0100 4664133 http://www.medworm.com/index.php?rid=4664132&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900074-4 Chao Shi, Ting Jia, Simon Mendez-Ferrer, Tobias M. Hohl, Natalya V. Serbina, Lauren Lipuma, Ingrid Leiner, Ming O. Li, Paul S. Frenette, Eric G. Pamer. Inflammatory (Ly6Chi CCR2+) monocytes provide defense against infections but also contribute to autoimmune diseases and atherosclerosis. Monocytes originate from bone marrow .... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4664132 Thu, 31 Mar 2011 00:00:00 +0100 4664132 http://www.medworm.com/index.php?rid=4632086&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900053-7 Min Fang, Mark T. Orr, Pieter Spee, Thomas Egebjerg, Lewis L. Lanier, Luis J. Sigal. It is well established that natural killer (NK) cells confer resistance to many viral diseases, but in only a few instances the molecular mechanisms whereby NK cells recognize virus-infected cells.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4632086 Thu, 24 Mar 2011 00:00:00 +0100 4632086 http://www.medworm.com/index.php?rid=4606473&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900081-1 Jason A. Hall, Jennifer L. Cannons, John R. Grainger, Liliane M. Dos Santos, Timothy W. Hand, Shruti Naik, Elizabeth A. Wohlfert, David B. Chou, Guillaume Oldenhove, Melody Robinson, Michael E. Grigg, Robin Kastenmayer, Pamela L. Schwartzberg, Yasmine Belkaid. Vitamin A and its metabolite, retinoic acid (RA) are implicated in the regulation of immune homeostasis via the peripheral induction of regulatory T cells. Here we showed RA was also required to e.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4606473 Thu, 17 Mar 2011 00:00:00 +0100 4606473 http://www.medworm.com/index.php?rid=4606472&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900078-1 Iwona Powolny-Budnicka, Marc Riemann, Simone Tänzer, Roland M. Schmid, Thomas Hehlgans, Falk Weih. The NF-κB transcription factor regulates numerous immune responses but its contribution to interleukin-17 (IL-17) production by T cells is largely unknown. Here, we report that IL-17, but not inte.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4606472 Thu, 17 Mar 2011 00:00:00 +0100 4606472 http://www.medworm.com/index.php?rid=4606471&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900075-6 We report that activation o.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4606471 Thu, 17 Mar 2011 00:00:00 +0100 4606471 http://www.medworm.com/index.php?rid=4545336&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900042-2 Ge Ma, Ping-Ying Pan, Samuel Eisenstein, Celia M. Divino, Clifford A. Lowell, Toshiyuki Takai, Shu-Hsia Chen. Myeloid-derived suppressor cells (MDSCs) bear characteristics of precursors for both M1 and M2 macrophages. The molecular mechanism underlying the differentiation into M1 and M2 macrophages and th.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4545336 Thu, 03 Mar 2011 00:00:00 +0100 4545336 http://www.medworm.com/index.php?rid=4545335&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900039-2 Kwok S. Wun, Garth Cameron, Onisha Patel, Siew Siew Pang, Daniel G. Pellicci, Lucy C. Sullivan, Santosh Keshipeddy, Mary H. Young, Adam P. Uldrich, Meena S. Thakur, Stewart K. Richardson, Amy R. Howell, Petr A. Illarionov, Andrew G. Brooks, Gurdyal S. Besra, James McCluskey, Laurent Gapin, Steven A. Porcelli, Dale I. Godfrey, Jamie Rossjohn. Natural killer T (NKT) cells respond to a variety of CD1d-restricted antigens (Ags), although the basis for Ag discrimination by the NKT cell receptor (TCR) is unclear. Here we have described NKT .... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4545335 Thu, 03 Mar 2011 00:00:00 +0100 4545335 http://www.medworm.com/index.php?rid=4545334&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900034-3 Thierry Mallevaey, Andrew J. Clarke, James P. Scott-Browne, Mary H. Young, Laila C. Roisman, Daniel G. Pellicci, Onisha Patel, Julian P. Vivian, Jennifer L. Matsuda, James McCluskey, Dale I. Godfrey, Philippa Marrack, Jamie Rossjohn, Laurent Gapin. The antigen receptor for natural killer T cells (NKT TCR) binds CD1d-restricted microbial and self-lipid antigens, although the molecular basis of self-CD1d recognition is unclear. Here, we have c.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4545334 Thu, 03 Mar 2011 00:00:00 +0100 4545334 http://www.medworm.com/index.php?rid=4518022&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900012-4 Baidong Hou, Philippe Saudan, Gary Ott, Matthew L. Wheeler, Ming Ji, Lili Kuzmich, Linda M. Lee, Robert L. Coffman, Martin F. Bachmann, Anthony L. DeFranco. The contribution of Toll-like receptor (TLR) signaling to T cell-dependent (TD) antibody responses was assessed by using mice lacking the TLR signaling adaptor MyD88 in individual cell types. When.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4518022 Thu, 24 Feb 2011 00:00:00 +0100 4518022 http://www.medworm.com/index.php?rid=4490387&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900040-9 Hiroyuki Tezuka, Yukiko Abe, Jumpei Asano, Taku Sato, Jiajia Liu, Makoto Iwata, Toshiaki Ohteki. Although both conventional dendritic cells (cDCs) and plasmacytoid dendritic cells (pDCs) are present in the gut-associated lymphoid tissues (GALT), the roles of pDCs in the gut remain largely unk.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4490387 Thu, 17 Feb 2011 00:00:00 +0100 4490387 http://www.medworm.com/index.php?rid=4490386&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900038-0 Xing Chang, Fang Liu, Xiaofang Wang, Aiping Lin, Hongyu Zhao, Bing Su. Mitogen-activated protein kinases (MAPKs) are key mediators of the T cell receptor (TCR) signals but their roles in T helper (Th) cell differentiation are unclear. Here we showed that the MAPK kin.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4490386 Thu, 17 Feb 2011 00:00:00 +0100 4490386 http://www.medworm.com/index.php?rid=4490385&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900037-9 Usriansyah Hadis, Benjamin Wahl, Olga Schulz, Matthias Hardtke-Wolenski, Angela Schippers, Norbert Wagner, Werner Müller, Tim Sparwasser, Reinhold Förster, Oliver Pabst. Tolerance to food antigen manifests in the absence and/or suppression of antigen-specific immune responses locally in the gut but also systemically, a phenomenon known as oral tolerance. Oral tole.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4490385 Thu, 17 Feb 2011 00:00:00 +0100 4490385 http://www.medworm.com/index.php?rid=4490384&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900035-5 Shelly M. Wuerzberger-Davis, Yuhong Chen, David T. Yang, Jeffrey D. Kearns, Paul W. Bates, Candace Lynch, Nicholas C. Ladell, Mei Yu, Andrew Podd, Hu Zeng, Tony T. Huang, Renren Wen, Alexander Hoffmann, Demin Wang, Shigeki Miyamoto. The N-terminal nuclear export sequence (NES) of inhibitor of nuclear factor kappa B (NF-κB) alpha (IκBα) promotes NF-κB export from the cell nucleus to the cytoplasm, but the physiological role of.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4490384 Thu, 17 Feb 2011 00:00:00 +0100 4490384 http://www.medworm.com/index.php?rid=4460620&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900036-7 Morgane Bomsel, Daniela Tudor, Anne-Sophie Drillet, Annette Alfsen, Yonatan Ganor, Marie-Gaëlle Roger, Nicolas Mouz, Mario Amacker, Anick Chalifour, Lorenzo Diomede, Gilles Devillier, Zhe Cong, Qiang Wei, Hong Gao, Chuan Qin, Gui-Bo Yang, Rinaldo Zurbriggen, Lucia Lopalco, Sylvain Fleury. Human immunodeficiency virus (HIV)-1 is mainly transmitted mucosally during sexual intercourse. We therefore evaluated the protective efficacy of a vaccine active at mucosal sites. Macaca mulat.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4460620 Thu, 10 Feb 2011 00:00:00 +0100 4460620 http://www.medworm.com/index.php?rid=4433356&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900033-1 Andrew N. Macintyre, David Finlay, Gavin Preston, Linda V. Sinclair, Caryll M. Waugh, Peter Tamas, Carmen Feijoo, Klaus Okkenhaug, Doreen A. Cantrell. In cytotoxic T cells (CTL), Akt, also known as protein kinase B, is activated by the T cell antigen receptor (TCR) and the cytokine interleukin 2 (IL-2). Akt can control cell metabolism in many ce.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4433356 Thu, 03 Feb 2011 00:00:00 +0100 4433356 http://www.medworm.com/index.php?rid=4378311&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2811%2900003-3 Manfred Nairz, Andrea Schroll, Alexander R. Moschen, Thomas Sonnweber, Milan Theurl, Igor Theurl, Nicole Taub, Christina Jamnig, Daniela Neurauter, Lukas A. Huber, Herbert Tilg, Patrizia L. Moser, Günter Weiss. Erythropoietin (EPO) is the principal cytokine regulating erythropoiesis through its receptor, EPOR. Interestingly, EPORs are also found on immune cells with incompletely understood functions. Her.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4378311 Thu, 20 Jan 2011 00:00:00 +0100 4378311 http://www.medworm.com/index.php?rid=4378310&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900496-6 Ning Jiang, Jun Huang, Lindsay J. Edwards, Baoyu Liu, Yan Zhang, Carrie D. Beal, Brian D. Evavold, Cheng Zhu. The T cell receptor (TCR) and CD8 bind peptide-major histocompatibility complex (pMHC) glycoproteins to initiate adaptive immune responses, yet the trimolecular binding kinetics at the T cell memb.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4378310 Thu, 20 Jan 2011 00:00:00 +0100 4378310 http://www.medworm.com/index.php?rid=4378309&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900495-4 Raghu P. Kataru, Honsoul Kim, Cholsoon Jang, Dong Kyu Choi, Bong Ihn Koh, Minah Kim, Sudheer Gollamudi, Yun-Keun Kim, Seung-Hyo Lee, Gou Young Koh. Lymph node lymphatic vessels (LNLVs) serve as a conduit to drain antigens from peripheral tissues to within the lymph nodes. LNLV density is known to be positively regulated by vascular endothelia.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4378309 Thu, 20 Jan 2011 00:00:00 +0100 4378309 http://www.medworm.com/index.php?rid=4343856&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900494-2 Patrick J. Shaw, Maggie J. Barr, John R. Lukens, Maureen A. McGargill, Hongbo Chi, Tak W. Mak, Thirumala-Devi Kanneganti. Peripheral peptidolgycan (PGN) is present within antigen-presenting cells in the central nervous system (CNS) of multiple sclerosis (MS) patients, possibly playing a role in neuroinflammation. Acc.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4343856 Thu, 13 Jan 2011 00:00:00 +0100 4343856 http://www.medworm.com/index.php?rid=4343854&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900493-0 Alejandro V. Villarino, Shoshana D. Katzman, Eugenio Gallo, Omer Miller, Shuwei Jiang, Michael T. McManus, Abul K. Abbas. Self-reactive T cell clones that escape negative selection are either deleted or rendered functionally unresponsive (anergic), thus preventing them from propagating host tissue damage. By using an.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4343854 Thu, 13 Jan 2011 00:00:00 +0100 4343854 http://www.medworm.com/index.php?rid=4319023&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900492-9 Gretta L. Stritesky, Rajarajeswari Muthukrishnan, Sarita Sehra, Ritobrata Goswami, Duy Pham, Jared Travers, Evelyn T. Nguyen, David E. Levy, Mark H. Kaplan. Signal transducer and activator of transcription (STAT) family members direct the differentiation of T helper cells, with specific STAT proteins promoting distinct effector subsets. STAT6 is requi.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4319023 Thu, 06 Jan 2011 00:00:00 +0100 4319023 http://www.medworm.com/index.php?rid=4319022&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900491-7 Rimpei Morita, Nathalie Schmitt, Salah-Eddine Bentebibel, Rajaram Ranganathan, Laure Bourdery, Gerard Zurawski, Emile Foucat, Melissa Dullaers, SangKon Oh, Natalie Sabzghabaei, Elizabeth M. Lavecchio, Marilynn Punaro, Virginia Pascual, Jacques Banchereau, Hideki Ueno. Although a fraction of human blood memory CD4+ T cells expresses chemokine (C-X-C motif) receptor 5 (CXCR5), their relationship to T follicular helper (Tfh) cells is not well establishe.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4319022 Thu, 06 Jan 2011 00:00:00 +0100 4319022 http://www.medworm.com/index.php?rid=4300782&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900490-5 Kenichi Asano, Ami Nabeyama, Yasunobu Miyake, Chun-Hong Qiu, Ai Kurita, Michio Tomura, Osami Kanagawa, Shin-ichiro Fujii, Masato Tanaka. The generation of tumor-directed cytotoxic T lymphocytes is considered crucial for the induction of antitumor immunity. To activate these CD8+ T cells, antigen-presenting cells (APCs) m.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4300782 Thu, 30 Dec 2010 00:00:00 +0100 4300782 http://www.medworm.com/index.php?rid=4300781&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900489-9 Koko Katagiri, Yoshihiro Ueda, Takashi Tomiyama, Kaneki Yasuda, Yoshinobu Toda, Susumu Ikehara, Keiichi I. Nakayama, Tatsuo Kinashi. RAPL (an alternative spliced form of Rassf5) is a critical Ras-related protein1 (Rap1) effector that regulates lymphocyte adhesion. Here, we have shown that in addition to this previously d.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4300781 Thu, 30 Dec 2010 00:00:00 +0100 4300781 http://www.medworm.com/index.php?rid=4300780&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900488-7 Gregory F. Sonnenberg, Laurel A. Monticelli, M. Merle Elloso, Lynette A. Fouser, David Artis. Fetal CD4+ lymphoid tissue inducer (LTi) cells play a critical role in the development of lymphoid tissues. Recent studies identified that LTi cells persist in adults and are related to.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4300780 Thu, 30 Dec 2010 00:00:00 +0100 4300780 http://www.medworm.com/index.php?rid=4266656&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900460-7 Yann M. Kerdiles, Erica L. Stone, Daniel L. Beisner, Maureen A. McGargill, Irene L. Ch'en, Christian Stockmann, Carol D. Katayama, Stephen M. Hedrick. Foxo transcription factors integrate extrinsic signals to regulate cell division, differentiation and survival, and specific functions of lymphoid and myeloid cells. Here, we showed the absence of.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4266656 Thu, 16 Dec 2010 00:00:00 +0100 4266656 http://www.medworm.com/index.php?rid=4266655&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900458-9 We report that mice lacking the POZ (Poxvirus and zinc finger) domain.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4266655 Thu, 16 Dec 2010 00:00:00 +0100 4266655 http://www.medworm.com/index.php?rid=4266654&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900457-7 Yanxing Yu, Gary S. Hayward. In the course of combating infectious agents, type I interferon (IFN) needs a timely downregulation mechanism to avoid detrimental overreaction. Here we showed a mechanism for restraining type I I.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4266654 Thu, 16 Dec 2010 00:00:00 +0100 4266654 http://www.medworm.com/index.php?rid=4266653&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900456-5 Louise Scharf, Nan-Sheng Li, Andrew J. Hawk, Diana Garzón, Tejia Zhang, Lisa M. Fox, Allison R. Kazen, Sneha Shah, Esmael J. Haddadian, Jenny E. Gumperz, Alan Saghatelian, José D. Faraldo-Gómez, Stephen C. Meredith, Joseph A. Piccirilli, Erin J. Adams. CD1 molecules function to present lipid-based antigens to T cells. Here we present the crystal structure of CD1c at 2.5 Å resolution, in complex with the pathogenic Mycobacterium tuberculosis (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4266653 Thu, 16 Dec 2010 00:00:00 +0100 4266653 http://www.medworm.com/index.php?rid=4266652&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900455-3 Lino L. Teichmann, Michelle L. Ols, Michael Kashgarian, Boris Reizis, Daniel H. Kaplan, Mark J. Shlomchik. Dendritic cells (DCs) initiate and control the adaptive immune response against infections. However, their contributions to the anti-self adaptive immune response in autoimmune disorders like syst.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4266652 Thu, 16 Dec 2010 00:00:00 +0100 4266652 http://www.medworm.com/index.php?rid=4245992&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900454-1 Claudio Procaccini, Veronica De Rosa, Mario Galgani, Luisa Abanni, Gaetano Calì, Antonio Porcellini, Fortunata Carbone, Silvia Fontana, Tamas L. Horvath, Antonio La Cava, Giuseppe Matarese. There is a discrepancy between the in vitro anergic state of CD4+CD25hiFoxP3+ regulatory T (Treg) cells and their in vivo proliferative capability. The underlying .... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4245992 Thu, 09 Dec 2010 00:00:00 +0100 4245992 http://www.medworm.com/index.php?rid=4245991&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900453-X Hiyaa S. Ghosh, Babacar Cisse, Anna Bunin, Kanako L. Lewis, Boris Reizis. The interferon-producing plasmacytoid dendritic cells (pDCs) share common progenitors with antigen-presenting classical dendritic cells (cDCs), yet they possess distinct morphology and molecular f.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4245991 Thu, 09 Dec 2010 00:00:00 +0100 4245991 http://www.medworm.com/index.php?rid=4245990&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900452-8 Madhav D. Sharma, De-Yan Hou, Babak Baban, Pandelakis A. Koni, Yukai He, Phillip R. Chandler, Bruce R. Blazar, Andrew L. Mellor, David H. Munn. Foxp3+ regulatory T (Treg) cells can undergo reprogramming into a phenotype expressing proinflammatory cytokines. However, the biologic significance of this conversion remains unclear. .... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4245990 Thu, 09 Dec 2010 00:00:00 +0100 4245990 http://www.medworm.com/index.php?rid=4245989&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900451-6 Cao-Qi Lei, Bo Zhong, Yu Zhang, Jing Zhang, Shuai Wang, Hong-Bing Shu. Viral infection activates transcription factors IRF3 and NF-κB, which collaborate to induce type I interferons (IFNs). Here, we identified glycogen synthase kinase 3β (GSK3β) as an important regul.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4245989 Thu, 09 Dec 2010 00:00:00 +0100 4245989 http://www.medworm.com/index.php?rid=4225102&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900450-4 Melissa Swiecki, Susan Gilfillan, William Vermi, Yaming Wang, Marco Colonna. Plasmacytoid dendritic cells (pDCs) mediate type I interferon (IFN-I) responses to viruses that are recognized through the Toll-like receptor 7 (TLR7) or TLR9 signaling pathway. However, it is unc.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4225102 Fri, 03 Dec 2010 05:00:06 +0100 4225102 http://www.medworm.com/index.php?rid=4183753&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900420-6 Agnieszka A. Wendorff, Ute Koch, F. Thomas Wunderlich, Silvia Wirth, Christelle Dubey, Jens C. Brüning, H. Robson MacDonald, Freddy Radtke. Although canonical Notch signaling regulates multiple hematopoietic lineage decisions including T cell and marginal zone B cell fate specification, the downstream molecular mediators of Notch func.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4183753 Fri, 19 Nov 2010 05:00:06 +0100 4183753 http://www.medworm.com/index.php?rid=4183752&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900419-X Henrik Flach, Marc Rosenbaum, Marlena Duchniewicz, Sola Kim, Shenyuan L. Zhang, Michael D. Cahalan, Gerhard Mittler, Rudolf Grosschedl. Marginal zone (MZ) B cells of the spleen and B1 cells, termed innate-like B cells, differ from follicular B cells by their attenuated Ca2+ mobilization, fast antibody secretion, and inc.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4183752 Fri, 19 Nov 2010 05:00:06 +0100 4183752 http://www.medworm.com/index.php?rid=4183751&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900416-4 Laura Belver, Virginia G. de Yébenes, Almudena R. Ramiro. MicroRNAs have been shown to be critical for a number of aspects of immune system regulation and function. Here, we have examined the role of microRNAs in terminal B cell differentiation by analyz.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4183751 Fri, 19 Nov 2010 05:00:06 +0100 4183751 http://www.medworm.com/index.php?rid=4183750&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900415-2 Attila Szanto, Balint L. Balint, Zsuzsanna S. Nagy, Endre Barta, Balazs Dezso, Attila Pap, Lajos Szeles, Szilard Poliska, Melinda Oros, Ronald M. Evans, Yaacov Barak, John Schwabe, Laszlo Nagy. Peroxisome proliferator-activated receptor γ (PPARγ) is a lipid-activated transcription factor regulating lipid metabolism and inflammatory response in macrophages and dendritic cells (DCs). These.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4183750 Fri, 19 Nov 2010 05:00:06 +0100 4183750 http://www.medworm.com/index.php?rid=4183749&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900414-0 Pablo Gómez-del Arco, Mariko Kashiwagi, Audrey F. Jackson, Taku Naito, Jiangwen Zhang, Feifei Liu, Barbara Kee, Marc Vooijs, Freddy Radtke, Juan Miguel Redondo, Katia Georgopoulos. Loss of the transcription factor Ikaros is correlated with Notch receptor activation in T cell acute lymphoblastic leukemia (T-ALL). However, the mechanism remains unknown. We identified promoters.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4183749 Fri, 19 Nov 2010 05:00:06 +0100 4183749 http://www.medworm.com/index.php?rid=4183748&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900404-8 Xingfeng Bao, E. Ashley Moseman, Hideo Saito, Bronislawa Petryanik, Aude Thiriot, Shingo Hatakeyama, Yuki Ito, Hiroto Kawashima, Yu Yamaguchi, John B. Lowe, Ulrich H. von Andrian, Minoru Fukuda. Heparan sulfate can bind several adhesion molecules involved in lymphocyte trafficking. However, the in vivo function of endothelial heparan sulfate in lymphocyte homing and stimulation of the imm.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4183748 Fri, 19 Nov 2010 05:00:06 +0100 4183748 http://www.medworm.com/index.php?rid=4183747&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900403-6 Cedric Vonarbourg, Arthur Mortha, Viet L. Bui, Pedro P. Hernandez, Elina A. Kiss, Thomas Hoyler, Melanie Flach, Bertram Bengsch, Robert Thimme, Christoph Hölscher, Manfred Hönig, Ulrich Pannicke, Klaus Schwarz, Carl F. Ware, Daniela Finke, Andreas Diefenbach. Whether the recently identified innate lymphocyte population coexpressing natural killer cell receptors (NKRs) and the nuclear receptor RORγt is part of the NK or lymphoid tissue inducer (LTi) cel.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4183747 Fri, 19 Nov 2010 05:00:06 +0100 4183747 http://www.medworm.com/index.php?rid=4183746&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900402-4 Patricia Neves, Vicky Lampropoulou, Elisabeth Calderon-Gomez, Toralf Roch, Ulrik Stervbo, Ping Shen, Anja A. Kühl, Christoph Loddenkemper, Matthias Haury, Sergei A. Nedospasov, Stefan H.E. Kaufmann, Ulrich Steinhoff, Dinis P. Calado, Simon Fillatreau. The myeloid differentiation primary response gene 88 (Myd88) is critical for protection against pathogens. However, we demonstrate here that MyD88 expression in B cells inhibits resistance .... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4183746 Fri, 19 Nov 2010 05:00:06 +0100 4183746 http://www.medworm.com/index.php?rid=4183745&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900401-2 Christoph Alexander Kasper, Isabel Sorg, Christoph Schmutz, Therese Tschon, Harry Wischnewski, Man Lyang Kim, Cécile Arrieumerlou. The enteroinvasive bacterium Shigella flexneri uses multiple secreted effector proteins to downregulate interleukin-8 (IL-8) expression in infected epithelial cells. Yet, massive IL-8 secre.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4183745 Fri, 19 Nov 2010 05:00:06 +0100 4183745 http://www.medworm.com/index.php?rid=4159727&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900400-0 Sung-Gyoo Park, Ramkumar Mathur, Meixiao Long, Namiko Hosh, Liming Hao, Matthew S. Hayden, Sankar Ghosh. Immune tolerance against enteric commensal bacteria is important for preventing intestinal inflammation. Deletion of phosphoinositide-dependent protein kinase 1 (Pdk1) in T cells via Cd4.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4159727 Fri, 12 Nov 2010 05:00:05 +0100 4159727 http://www.medworm.com/index.php?rid=4159726&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900399-7 Tetsuo Tsuchida, Jian Zou, Tatsuya Saitoh, Himanshu Kumar, Takayuki Abe, Yoshiharu Matsuura, Taro Kawai, Shizuo Akira. The innate immune system detects pathogen- and host-derived double-stranded DNA exposed to the cytosol and induces type I interferon (IFN) and other cytokines. Here, we identified interferon-induc.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4159726 Fri, 12 Nov 2010 05:00:05 +0100 4159726 http://www.medworm.com/index.php?rid=4135061&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900372-9 Natasha K. Crellin, Sara Trifari, Charles D. Kaplan, Naoko Satoh-Takayama, James P. Di Santo, Hergen Spits. Lymphoid tissue inducer cells are members of an emerging family of innate lymphoid cells (ILC). Although these cells were originally reported to produce cytokines such as interleukin-17 (IL-17) an.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4135061 Fri, 05 Nov 2010 05:00:07 +0100 4135061 http://www.medworm.com/index.php?rid=4067727&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900359-6 Jacques Deguine, Béatrice Breart, Fabrice Lemaître, James P. Di Santo, Philippe Bousso. Recognition of NKG2D ligands by natural killer (NK) cells plays an important role during antitumoral responses. To address how NKG2D engagement affects intratumoral NK cell dynamics, we performed .... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4067727 Fri, 15 Oct 2010 04:00:06 +0100 4067727 http://www.medworm.com/index.php?rid=4041088&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900355-9 Taheri Sathaliyawala, William E. O'Gorman, Melanie Greter, Milena Bogunovic, Vjollca Konjufca, Z. Esther Hou, Garry P. Nolan, Mark J. Miller, Miriam Merad, Boris Reizis. Dendritic cells (DCs) comprise distinct functional subsets including CD8− and CD8+ classical DCs (cDCs) and interferon-secreting plasmacytoid DCs (pDCs). The cytokine Flt3 li.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4041088 Fri, 08 Oct 2010 04:00:05 +0100 4041088 http://www.medworm.com/index.php?rid=4041087&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900352-3 We described a trafficking pathway for TLR4 from the endocytic recycling compartment (ERC) to E. coli.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4041087 Fri, 08 Oct 2010 04:00:05 +0100 4041087 http://www.medworm.com/index.php?rid=4023818&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900351-1 Ryan M. O'Connell, Daniel Kahn, William S.J. Gibson, June L. Round, Rebecca L. Scholz, Aadel A. Chaudhuri, Melissa E. Kahn, Dinesh S. Rao, David Baltimore. Mammalian noncoding microRNAs (miRNAs) are a class of gene regulators that have been linked to immune system function. Here, we have investigated the role of miR-155 during an autoimmune inflammat.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=4023818 Fri, 01 Oct 2010 04:00:06 +0100 4023818 http://www.medworm.com/index.php?rid=3977655&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900322-5 Yoshiki Omatsu, Tatsuki Sugiyama, Hiroshi Kohara, Gen Kondoh, Nobutaka Fujii, Kenji Kohno, Takashi Nagasawa. Hematopoietic stem cells (HSCs) and their lympho-hematopoietic progeny are supported by microenvironmental niches within bone marrow; however, the identity, nature, and function of these niches re.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=3977655 Fri, 17 Sep 2010 04:00:06 +0100 3977655 http://www.medworm.com/index.php?rid=3977654&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900321-3 Hélène Beuneu, Fabrice Lemaître, Jacques Deguine, Hélène D. Moreau, Isabelle Bouvier, Zacarias Garcia, Matthew L. Albert, Philippe Bousso. CD8+ T cell responses generate effector cells endowed with distinct functional potentials but the contribution of early events in this process is unclear. Here, we have imaged T cells e.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=3977654 Fri, 17 Sep 2010 04:00:06 +0100 3977654 http://www.medworm.com/index.php?rid=3977653&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900320-1 Wenwen Xu, Ping Wang, Björn Petri, Yong Zhang, Wenwen Tang, Le Sun, Holger Kress, Tom Mann, Yan Shi, Paul Kubes, Dianqing Wu. Neutrophils are important in innate immunity and acute inflammatory responses. However, the regulation of their recruitment to sites of inflammation has not been well characterized. Here, we inves.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=3977653 Fri, 17 Sep 2010 04:00:05 +0100 3977653 http://www.medworm.com/index.php?rid=3955451&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900319-5 Rebeca Pérez de Diego, Vanessa Sancho-Shimizu, Lazaro Lorenzo, Anne Puel, Sabine Plancoulaine, Capucine Picard, Melina Herman, Annabelle Cardon, Anne Durandy, Jacinta Bustamante, Sivakumar Vallabhapurapu, Jerónimo Bravo, Klaus Warnatz, Yves Chaix, Françoise Cascarrigny, Pierre Lebon, Flore Rozenberg, Michael Karin, Marc Tardieu, Saleh Al-Muhsen, Emmanuelle Jouanguy, Shen-Ying Zhang, Laurent Abel, Jean-Laurent Casanova. Tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) functions downstream of multiple TNF receptors and receptors that induce interferon-α (IFN-α), IFN-β, and IFN-λ production, includi.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=3955451 Fri, 10 Sep 2010 04:00:05 +0100 3955451 http://www.medworm.com/index.php?rid=3955450&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900318-3 Franziska Petermann, Veit Rothhammer, Malte C. Claussen, Jan D. Haas, Lorena Riol Blanco, Sylvia Heink, Immo Prinz, Bernhard Hemmer, Vijay K. Kuchroo, Mohamed Oukka, Thomas Korn. Mice that lack interleukin-23 (IL-23) are resistant to T cell-mediated autoimmunity. Although IL-23 is a maturation factor for T helper 17 (Th17) cells, a subset of γδ T cells expresses the IL-23 .... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=3955450 Fri, 10 Sep 2010 04:00:05 +0100 3955450 http://www.medworm.com/index.php?rid=3955449&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900317-1 Jérôme Cros, Nicolas Cagnard, Kevin Woollard, Natacha Patey, Shen-Ying Zhang, Brigitte Senechal, Anne Puel, Subhra K. Biswas, Despina Moshous, Capucine Picard, Jean-Philippe Jais, David D'Cruz, Jean-Laurent Casanova, Céline Trouillet, Fréderic Geissmann. Monocytes are effectors of the inflammatory response to microbes. Human CD14+ monocytes specialize in phagocytosis and production of reactive oxygen species and secrete inflammatory cyt.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=3955449 Fri, 10 Sep 2010 04:00:05 +0100 3955449 http://www.medworm.com/index.php?rid=3929541&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900316-X Caspar Ohnmacht, Christian Schwartz, Marc Panzer, Isabell Schiedewitz, Ronald Naumann, David Voehringer. Basophils are associated with T helper 2 (Th2) cell-polarized immune responses such as allergic disorders or helminth infections. To directly address the role of basophils for type 2 immunity, we .... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=3929541 Fri, 03 Sep 2010 04:00:06 +0100 3929541 http://www.medworm.com/index.php?rid=3886398&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900286-4 Alexandre Darmoise, Susann Teneberg, Lauriane Bouzonville, Roscoe O. Brady, Michael Beck, Stefan H.E. Kaufmann, Florian Winau. Natural Killer T (NKT) cells are lipid-reactive, CD1d-restricted T lymphocytes important in infection, cancer, and autoimmunity. In addition to foreign antigens, NKT cells react with endogenous se.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=3886398 Fri, 20 Aug 2010 04:00:07 +0100 3886398 http://www.medworm.com/index.php?rid=3886397&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900285-2 Xinyuan Zhou, Shuyang Yu, Dong-Mei Zhao, John T. Harty, Vladimir P. Badovinac, Hai-Hui Xue. T cell factor 1 (TCF-1) is a transcription factor known to act downstream of the canonical Wnt pathway and is essential for normal T cell development. However, its physiological roles in mature CD.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=3886397 Fri, 20 Aug 2010 04:00:07 +0100 3886397 http://www.medworm.com/index.php?rid=3886396&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900284-0 Dominique Davidson, Xiaochu Shi, Ming-Chao Zhong, Inmoo Rhee, André Veillette. PTP-PEST (encoded by Ptpn12) is an intracellular protein tyrosine phosphatase belonging to the same family as LYP. LYP inhibits secondary T cell responses by suppressing Src family protein .... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=3886396 Fri, 20 Aug 2010 04:00:06 +0100 3886396 http://www.medworm.com/index.php?rid=3886395&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900283-9 Richard C. Chou, Nancy D. Kim, Christian D. Sadik, Edward Seung, Yinan Lan, Michael H. Byrne, Bodduluri Haribabu, Yoichiro Iwakura, Andrew D. Luster. A large and diverse array of chemoattractants control leukocyte trafficking, but how these apparently redundant signals collaborate in vivo is still largely unknown. We previously demonstrated an .... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=3886395 Fri, 20 Aug 2010 04:00:06 +0100 3886395 http://www.medworm.com/index.php?rid=3862898&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900282-7 Rita M. Tavares, Emre E. Turer, Chih L. Liu, Rommel Advincula, Patrizia Scapini, Lesley Rhee, Julio Barrera, Clifford A. Lowell, Paul J. Utz, Barbara A. Malynn, Averil Ma. A20 is a ubiquitin modifying enzyme that restricts NF-κB signals and protects cells against tumor necrosis factor (TNF)-induced programmed cell death. Given recent data linking A20 (TNFAIP3.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=3862898 Fri, 13 Aug 2010 04:00:06 +0100 3862898 http://www.medworm.com/index.php?rid=3828568&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900281-5 Kristen L. Hoek, Laura E. Gordy, Patrick L. Collins, Vrajesh V. Parekh, Thomas M. Aune, Sebastian Joyce, James W. Thomas, Luc Van Kaer, Eric Sebzda. Follicular (FO) and marginal zone (MZ) B cells are maintained in distinct locations within the spleen, but the genetic basis for this separation is still enigmatic. We now report that B cell seque.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=3828568 Fri, 06 Aug 2010 04:00:06 +0100 3828568 http://www.medworm.com/index.php?rid=3828567&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900280-3 Elissa K. Deenick, Anna Chan, Cindy S. Ma, Dominique Gatto, Pamela L. Schwartzberg, Robert Brink, Stuart G. Tangye. Effective humoral immunity depends on the support of B cell responses by T follicular helper (Tfh) cells. Although it has been proposed that Tfh cell differentiation requires T-B interactions, the.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=3828567 Fri, 06 Aug 2010 04:00:06 +0100 3828567 http://www.medworm.com/index.php?rid=3803480&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900279-7 Valérie Staudt, Evita Bothur, Matthias Klein, Karen Lingnau, Sebastian Reuter, Nadine Grebe, Bastian Gerlitzki, Markus Hoffmann, Alexander Ulges, Christian Taube, Nina Dehzad, Marc Becker, Michael Stassen, Andrea Steinborn, Michael Lohoff, Hansjörg Schild, Edgar Schmitt, Tobias Bopp. Interferon-regulatory factor 4 (IRF4) is essential for the development of T helper 2 (Th2) and Th17 cells. Herein, we report that IRF4 is also crucial for the development and function of an interl.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=3803480 Fri, 30 Jul 2010 04:00:07 +0100 3803480 http://www.medworm.com/index.php?rid=3803479&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900255-4 Mihalis Verykokakis, Markus D. Boos, Albert Bendelac, Barbara L. Kee. CD8+ T cells are selected via low-affinity interaction with MHC class I molecules on thymic epithelial cells (TECs). However, compromised T cell receptor signaling was proposed to force.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=3803479 Fri, 30 Jul 2010 04:00:07 +0100 3803479 http://www.medworm.com/index.php?rid=3759225&cid=s_33171_3_f&fid=33171&url=http%3A%2F%2Fwww.cell.com%2Fimmunity%2Fabstract%2FS1074-7613%2810%2900244-X Haining Huang, Myung-shin Jeon, Lujian Liao, Chun Yang, Chris Elly, John R. Yates, Yun-Cai Liu. Tagging the cell surface receptor with ubiquitin is believed to provide a signal for the endocytic pathway. E3 ubiquitin ligases such as Cbl-b and Itch have been implicated in T cell activation an.... (Source: Immunity) Immunity journals http://www.medworm.com/rss/comments.php?id=3759225 Fri, 16 Jul 2010 04:00:05 +0100 3759225