MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Indian Journal of Pharmaceutical Sciences' source. Wed, 08 Feb 2012 14:04:16 +0100 http://www.medworm.com/index.php?rid=5572319&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F2%2F250%2F91577 This study was undertaken to investigate the possible effect of hydroalcoholic root extract of Rubia cordifolia against indomethacin-induced enterocolitis in rats. Male Wistar rats received vehicle or hydroalcoholic root extract of Rubia cordifolia (300 and 600 mg/kg) for 11 consecutive days. Enterocolitis was induced by subcutaneous administration of indomethacin (7.5 mg/kg) on 8 th and 9 th day. The colonic mucosal injury was assessed by macroscopic scoring and histopathological examination. Furthermore, the serum lactate dehydrogenase activity was estimated. Indomethacin treatment to rats produced acute intestinal inflammation, manifested by a thickening of the bowel wall, mesenteric haemorrhage, mesentery adhesion and multiple mucosal ulcers of small intestine and colon. Treatment with... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5572319 Sat, 07 Jan 2012 05:00:00 +0100 5572319 http://www.medworm.com/index.php?rid=5572318&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F2%2F247%2F91576 A Sabitha Rani, K Saritha, V Nagamani, G SulakshanaIndian Journal of Pharmaceutical Sciences 2011 73(2):247-249Antifungal activity of Embelia ribes was evaluated on eight different fungal species by employing various concentrations of seed extract (0.5-2.0 mg). All the concentrations of seed extract inhibited the fungal growth, whereas maximum activity was observed at 2.0 mg concentration of seed extract. Among different doses, the diameter of inhibition zones ranged from 9 to 18 mm in various fungal species and increased with the increase in the concentration of test solution. Among all the fungi, high inhibition zones were observed in Colletotricum crassipes (18 mm). This was followed by Cladosporium (17.5 mm), Armillaria mellea (17 mm), Colletotricum capsici (17 mm), Aspergillus niger (... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5572318 Sat, 07 Jan 2012 05:00:00 +0100 5572318 http://www.medworm.com/index.php?rid=5572317&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F2%2F243%2F91575 K. R. S. Sambasiva Rao, MV Nagabhushanam, K. P. R. ChowdaryIndian Journal of Pharmaceutical Sciences 2011 73(2):243-247Solid dispersions of mefanamic acid with a water-soluble polymer polyvinyl pyrrolidine and a super disintegrant, primojel were prepared by common solvent and solvent evaporation methods employing methanol as the solvent. The dissolution rate and dissolution efficiency of the prepared solid dispersions were evaluated in comparison to the corresponding pure drug. Solid dispersions of mefenamic acid showed a marked enhancement in dissolution rate and dissolution efficiency. At 1:4 ratio of mefenamic acid-primojel a 2.61 fold increase in the dissolution rate of mefenamic acid was observed with solid dispersion. The solid dispersions in combined carriers gave much higher rates ... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5572317 Sat, 07 Jan 2012 05:00:00 +0100 5572317 http://www.medworm.com/index.php?rid=5572316&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F2%2F240%2F91573 The objective of this work was to develop and validate a simple, rapid, precise, and accurate high performance thin layer chromatography method for simultaneous determination of withanolide A and bacoside A in combined dosage form. The stationary phase used was silica gel G60F 254 . The mobile phase used was mixture of ethyl acetate: methanol: toluene: water (4:1:1:0.5 v/v/v/v). The detection of spots was carried out at 320 nm using absorbance reflectance mode. The method was validated in terms of linearity, accuracy, precision and specificity. The calibration curve was found to be linear between 200 to 800 ng/spot for withanolide A and 50 to 350 ng/spot for bacoside A. The limit of detection and limit of quantification for the withanolide A were found to be 3.05 and 10.06 ng/spot, respect... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5572316 Sat, 07 Jan 2012 05:00:00 +0100 5572316 http://www.medworm.com/index.php?rid=5572315&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F2%2F235%2F91571 HV Govinda, S. M. B. AsdaqIndian Journal of Pharmaceutical Sciences 2011 73(2):235-240The aim of the current research was to evaluate the immunomodulatory potential of methanol extract of Aegle marmelos in an experimental animal model of cellular and humoral immunity. Administration of methanol extract of Aegle marmelos (500 and 1000 mg/kg, p.o.) and Ocimum sanctum (100 mg/kg, p.o.), produced significant increase in adhesion of neutrophils and an increase in phagocytic index in carbon clearance assay. Both doses of Aegle marmelos prevented the mortality induced by bovine Pasteurella multocida in mice. Moreover, all treated groups demonstrated significant elevation in circulating antibody titre in the indirect haemagglunation test. From the above results, it can be concluded that methanol e... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5572315 Sat, 07 Jan 2012 05:00:00 +0100 5572315 http://www.medworm.com/index.php?rid=5572314&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F2%2F233%2F91570 RS Verma, RK Verma, A Chauhan, AK YadavIndian Journal of Pharmaceutical Sciences 2011 73(2):233-235Thymus serpyllum L. grown in Kumaon region of Western Himalaya was investigated for essential oil content and composition in different seasons. The oils of fresh samples were obtained by hydrodistillation. The yield of essential oil (% v/w) during different seasons varied from 0.07 to 0.28% with the highest in summer season, at vegetative stage. The oils were analyzed by GC and GC-MS. Major components of all the samples were thymol (19.4-60.1%), λ-terpinene (0.3-13.8%) and p-cymene (3.5-10.4%). The results clearly indicated that season has significant effect on quality and quantity of thyme oil. (Source: Indian Journal of Pharmaceutical Sciences) Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5572314 Sat, 07 Jan 2012 05:00:00 +0100 5572314 http://www.medworm.com/index.php?rid=5572313&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F2%2F231%2F91568 P Ghosh, P Chakraborty, A Mandal, MG Rasul, Madhumita Chakraborty, A SahaIndian Journal of Pharmaceutical Sciences 2011 73(2):231-233Two triterpenoids, taraxerone and tricadenic acid A were isolated from the methanol extract of the outer bark of Schleichera oleosa available in Darjeeling foothills. A preliminary study on their antimicrobial activities was also performed against some fungal and bacterial species. The structure of these compounds was determined by means of chemical characterisation and IR, NMR spectral data. (Source: Indian Journal of Pharmaceutical Sciences) Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5572313 Sat, 07 Jan 2012 05:00:00 +0100 5572313 http://www.medworm.com/index.php?rid=5572312&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F2%2F228%2F91567 Githa E Mathew, B Mathew, MM Shaneeb, B NyantharaIndian Journal of Pharmaceutical Sciences 2011 73(2):228-230The present study was undertaken to establish the diuretic activity of ethanol and aqueous extract of dried leaves of Garcinia cambogia in rats. Aqueous and ethanol extracts of leaves were administered to experimental rats orally at doses of 100 and 200 mg/kg and compared with furosemide (20 mg/kg, intraperitoneally) as the standard. The parameters measured for diuretic activity were total urine volume, urine concentration electrolytes such as sodium, potassium and chloride have been evaluated . The rats treated with ethanol extract of Garcinia cambogia and aqueous extract of Garcinia cambogia in a dose of 100 and 200 mg/kg showed higher urine output when compared to the respective ... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5572312 Sat, 07 Jan 2012 05:00:00 +0100 5572312 http://www.medworm.com/index.php?rid=5572311&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F2%2F223%2F91566 Sonashia Velho-Pereira, NM KamatIndian Journal of Pharmaceutical Sciences 2011 73(2):223-228Out of the 30 actinobacterial cultures screened for antimicrobial activity, 28 cultures were found to produce active products against various pathogenic microorganisms such as Gram-negative, Gram-positive bacteria and yeast, using a modified cross streak method. The modified method helped in easy quantification of results and also in ruling out probable mutual antibiosis. The actinobacterial strains that showed the ability to produce antimicrobial compounds belonged to Streptomyces (53%), Micromonospora (13%) and Actinomadura (10%) genera. Streptomyces sp. strain MMA-5 showed the highest multispecific antibiosis efficiency score value. Broad antibiotic spectrum activity was exhi... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5572311 Sat, 07 Jan 2012 05:00:00 +0100 5572311 http://www.medworm.com/index.php?rid=5572310&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F2%2F219%2F91565 ND Rawool, A VenkatchalamIndian Journal of Pharmaceutical Sciences 2011 73(2):219-223The present study deals with the estimation by RP-HPLC of two different drug components hydrochlorothiazide and metoprolol tartrate present in a tablet formulation. It is a simple, fast, precise and accurate high performance liquid chromatographic method. It is performed using phosphate buffer along with methanol as mobile phase, in the proportion of 60:40. The separation is done on a C 18 column and it is estimated at a λmax of 226 nm with a flow of 1 ml/min. The detection limits range from a 0.013 to 0.075 mg/ml for hydrochlorothiazide and 0.10 to 0.60 mg/ml for metoprolol tartrate, respectively. The specificity for interference of any peak with main peak of interest is checked. A scan of the... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5572310 Sat, 07 Jan 2012 05:00:00 +0100 5572310 http://www.medworm.com/index.php?rid=5572309&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F2%2F216%2F91563 AK Pandey, Vijayalakshmi OjhaIndian Journal of Pharmaceutical Sciences 2011 73(2):216-219Embelin (2,5-dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-benzoquinone) is a phenolic compound found in the fruits of Embelia tsjeriam-cottam and is responsible for the medicinal properties of the plant Thus the fruits are harvested at a large scale before maturity leading to depletion of population. Since the chemical constituents of medicinal plants are directly associated with the harvesting time, a study was conducted in different forest areas of Chhattisgarh, India, to standardize the harvesting time of Baividang fruits on the basis of their embelin content during 2005-08. The embelin content was determined by RP-HPLC and varied from 1.09 to 5.21% (w/w). The immature fruits collected in Octob... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5572309 Sat, 07 Jan 2012 05:00:00 +0100 5572309 http://www.medworm.com/index.php?rid=5572308&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F2%2F208%2F91579 KJ Wadher, RB Kakde, MJ UmekarIndian Journal of Pharmaceutical Sciences 2011 73(2):208-215Metformin hydrochloride has relatively short plasma half-life, low absolute bioavailability. The need for the administration two to three times a day when larger doses are required can decrease patient compliance. Sustained release formulation that would maintain plasma level for 8-12 h might be sufficient for daily dosing of metformin. Sustained release products are needed for metformin to prolong its duration of action and to improve patient compliances. The overall objective of this study was to develop an oral sustained release metformin hydrochloride tablet by using hydrophilic Eudragit RSPO alone or its combination with hydrophobic natural polymers Gum copal and gum damar as rate controlling fac... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5572308 Sat, 07 Jan 2012 05:00:00 +0100 5572308 http://www.medworm.com/index.php?rid=5572307&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F2%2F199%2F91581 VV Dabholkar, SD ParabIndian Journal of Pharmaceutical Sciences 2011 73(2):199-207A series of new dicarboxylic acid derivatives of 1,3,4-thiadiazines, 1,4-benzopiperizines, 1,4-thiazines, 1,3-thiazoles, 1,3-oxazoles and 1,3-imidazoles have been synthesized in 80-87% yield by the environmentally benign microwave induced technique involving the cyclocondensation of 2,3-dibromosuccinic acid with 2-aminothiophenol, o-phenylene diamine, 1,2,4-triazole, amidinothiocarbamide, amidinocarbamide and guanidine hydrochloride. The structures of all newly synthesized compounds have been established on the basis of analytical and spectral data. Evaluation of antibacterial and antifungal activity showed that almost all compounds exhibited better results than reference drugs thus they could be promi... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5572307 Sat, 07 Jan 2012 05:00:00 +0100 5572307 http://www.medworm.com/index.php?rid=5572306&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F2%2F193%2F91582 A. H. M. Viswanatha Swamy, M Sajjan, A. H. M. Thippeswamy, BC Koti, AJ SadiqIndian Journal of Pharmaceutical Sciences 2011 73(2):193-198The present study was designed to compare the curative role of proton pump inhibitors, omeprazole, rabeprazole and lansoprazole against dexamethasone-induced ulcer model. Dexamethasone (5 mg/kg/day) was used as an ulcerogen. Dexamethasone suspended in 1% CMC in water was given orally to all rats. Omeprazole (20 mg/kg), rabeprazole (20 mg/kg), and lansoprazole (20 mg/kg) were administered by oral route 30 minutes prior to dexamethasone for ulcer protective studies, gastric secretion and mucosal studies. Effects of proton pump inhibitors were determined by the evaluation of various biochemical parameters such as estimation of myeloperoxidase, cortisol... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5572306 Sat, 07 Jan 2012 05:00:00 +0100 5572306 http://www.medworm.com/index.php?rid=5572305&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F2%2F184%2F91583 NT Pandit, VB PatravaleIndian Journal of Pharmaceutical Sciences 2011 73(2):184-192Genistein, an isoflavone, has been demonstrated to promote the health of human beings by reducing the incidence of specific chronic diseases, namely, cancer and atherosclerosis. The present investigation explores a novel method of extraction of genistein from soy source which consists of a bioconversion reaction using fermentation by microorganism namely Streptomyces roseolus NRRL B-5424. In situ bioconversion of genistein glycoside to aglycone was carried out by the microbe. Such methodology has not been reported hitherto. Optimization of upstream and downstream parameters was done for maximum extraction of genistein. Genistein was isolated in a powder form by column chromatography and preparative thin laye... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5572305 Sat, 07 Jan 2012 05:00:00 +0100 5572305 http://www.medworm.com/index.php?rid=5572304&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F2%2F179%2F91585 RK Maheshwari, Y JagwaniIndian Journal of Pharmaceutical Sciences 2011 73(2):179-183Conventional furosemide tablets are practically insoluble in water, have slow onset of action (45-60 min) and poor bioavailability (39-53%), and therefore cannot be given in emergency clinical situations like hypertension or pulmonary edema. So purpose of research was to provide a fast dissolving oral dosage form of furosemide, which can provide quick onset of action by using concept of mixed hydrotropy. Initially solubility of furosemide was determined individually in 4 hydrotropic agents namely urea, sodium acetate, sodium benzoate, sodium citrate at concentration of 10, 20, 30 and 40% w/v solutions using purified water as solvent. Highest solubility was obtained in 40% sodium benzoat... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5572304 Sat, 07 Jan 2012 05:00:00 +0100 5572304 http://www.medworm.com/index.php?rid=5572303&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F2%2F171%2F91586 Poonam Yadav, Nalini V PurohitIndian Journal of Pharmaceutical Sciences 2011 73(2):171-178In this paper we report the synthesis of a new family of 4-alkyl isocoumarin derivatives having bromo carbonyl and amino carbonyl group at 3rd position of the heterocyclic ring. Synthesis, spectral analysis and bioactivity of new isocoumarin derivatives are discussed in this paper. Some of the synthesized compounds displayed comparable antibacterial activity and some of the new compounds showed an interesting inhibitory effect on the growth of four pathogen fungi involved in plant diseases. A fair number of compounds were found to have good analgesic property on comparing with standard drug analgin. (Source: Indian Journal of Pharmaceutical Sciences) Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5572303 Sat, 07 Jan 2012 05:00:00 +0100 5572303 http://www.medworm.com/index.php?rid=5572302&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F2%2F165%2F91584 This study is helpful for screening potent inhibitors of protein kinases. (Source: Indian Journal of Pharmaceutical Sciences) Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5572302 Sat, 07 Jan 2012 05:00:00 +0100 5572302 http://www.medworm.com/index.php?rid=5572301&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F2%2F159%2F91580 N Das, M Dhanawat, SK ShrivastavaIndian Journal of Pharmaceutical Sciences 2011 73(2):159-164The purpose of the present study is to undertake a docking study of some benzoxazinone derivatives on human peroxisome proliferator activated receptor co-crystallized with an alpha-aryloxyphenylacetic acid agonist using Glide 4.5. The QikProp program was used to obtain the absorption, distribution, metabolism and excretion properties of the analogues. The intermolecular hydrogen bonding interaction of the best-fit ligands were found to be associated with Tyr473, Ser289, Hie 449, Hip 323, Ser 342 and Gly 284 amino acid residue at the receptor active site. Among all the observed interaction with similar binding pattern, the presence of methyl carboxypentyl side chain (Lig. No. 21) showed additional i... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5572301 Sat, 07 Jan 2012 05:00:00 +0100 5572301 http://www.medworm.com/index.php?rid=5572300&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F2%2F152%2F91578 SN Patere, AS Majumdar, MN SarafIndian Journal of Pharmaceutical Sciences 2011 73(2):152-158The hypothesis that excessive intake of vegetable oil containing polyunsaturated fatty acids and iron load precipitate alcohol-induced liver damage was investigated in a rat model. In order to elucidate the mechanism underlying this synergism, the serum levels of iron, total protein, serum glutamate pyruvate transaminase, liver thiobarbituric acid reactive substances, and activities of antioxidant enzymes superoxide dismutase, catalase in liver of rats treated with alcohol, polyunsaturated fatty acids and iron per se and in combination were examined. Alcohol was fed to the rats at a level of 10-30% (blood alcohol was maintained between 150-350 mg/dl by using head space gas chromatography), po... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5572300 Sat, 07 Jan 2012 05:00:00 +0100 5572300 http://www.medworm.com/index.php?rid=5572299&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F2%2F146%2F91574 Nilima S Rajurkar, SM HandeIndian Journal of Pharmaceutical Sciences 2011 73(2):146-151The powder samples and methanol extract of 11 medicinal plants were subjected to analysis of proximate composition and measurement of antioxidant activity. Different parameters studied include phenolic contents, moisture, ash, crude fiber, fats and waxes. The assays employed were ferric reducing antioxidant power, trolox equivalent antioxidant capacity and scavenging effect on the 1,1-diphenyl-2-picrylhydrazyl free radical. Results obtained indicate that the antioxidant potential varied significantly from plant to plant. The total phenolic contents were determined spectrophotometrically using Folin-Ciocalteu reagent. Significant correlation is observed between ferric reducing antioxidant power and phenol... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5572299 Sat, 07 Jan 2012 05:00:00 +0100 5572299 http://www.medworm.com/index.php?rid=5572298&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F2%2F139%2F91572 A. H. M. Viswanathaswamy, BC Koti, Aparna Gore, A. H. M. Thippeswamy, RV KulkarniIndian Journal of Pharmaceutical Sciences 2011 73(2):139-145The present study was undertaken to investigate the antihyperglycemic and antihyperlipidemic effects of ethanol extract of Plectranthus amboinicus in normal and alloxan-induced diabetic rats. Diabetes was induced in Wistar rats by single intraperitoneal administration of alloxan monohydrate (150 mg/kg). Normal as well as diabetic rats were divided into groups (n=6) receiving different treatments. Graded doses (200 mg/kg and 400 mg/kg) of ethanol extract of Plectranthus amboinicus were studied in both normal and alloxan-induced diabetic rats for a period of 15 days. Glibenclamide (600 μg/kg) was used as a reference drug. Oral administration... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5572298 Sat, 07 Jan 2012 05:00:00 +0100 5572298 http://www.medworm.com/index.php?rid=5572297&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F2%2F131%2F91569 E Salva, SO Turan, J AkbugaIndian Journal of Pharmaceutical Sciences 2011 73(2):131-138Granulocyte macrophage colony stimulating factor, a potent hematopoietic cytokine, has been shown to stimulate production of white blood cells following chemotherapy. Therefore, the granulocyte macrophage colony stimulating factor gene is a potential candidate for the treatment of different pathological conditions. The purpose of this study is to investigate the suitability of chitosan as carrier for pORF-hGMCSF plasmid encoding granulocyte macrophage colony stimulating factor gene and also to study the effect of complexes on protein production and cell proliferation. Chitosan/pGM-CSF complexes were prepared using different (+/-) ratios (from 0.01/1 to 5/1). Complex formation was checked with agar... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5572297 Sat, 07 Jan 2012 05:00:00 +0100 5572297 http://www.medworm.com/index.php?rid=5572296&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F2%2F125%2F91564 J Sanmukhani, CB TripathiIndian Journal of Pharmaceutical Sciences 2011 73(2):125-130Ethics in clinical research focuses largely on identifying and implementing the acceptable conditions for exposure of some individuals to risks and burdens for the benefit of society at large. Ethical guidelines for clinical research were formulated only after discovery of inhumane behaviour with participants during research experiments. The Nuremberg Code was the first international code laying ethical principles for clinical research. With increasing research all over, World Health Organization formulated guidelines in the form of Declaration of Helsinki in 1964. The US laid down its guidelines for ethical principles in the Belmont Report after discovery of the Tuskegee's Syphilis study. The India... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5572296 Sat, 07 Jan 2012 05:00:00 +0100 5572296 http://www.medworm.com/index.php?rid=5400893&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F1%2F120%2F89772 B Dhanya, AK Sen, U Sahoo, AK Seth, A Suganthi, TK RaviIndian Journal of Pharmaceutical Sciences 2011 73(1):120-122A simple, precise and rapid RP-HPLC method was developed for the determination of doxazosin mesylate in pharmaceutical formulations. The method was carried out on a Chromolith RP-C 18 column using a mixture of potassium phosphate buffer and methanol (40:60 v/v) and detection was done at 251 nm. The linearity range was 1-5 μg/ml. The retention time of the drug was 3.8 min. The LOD and LOQ were found to be 0.1 μg/ml and 0.5 μg/ml, respectively. (Source: Indian Journal of Pharmaceutical Sciences) Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5400893 Fri, 11 Nov 2011 05:00:00 +0100 5400893 http://www.medworm.com/index.php?rid=5400892&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F1%2F115%2F89771 In this study, various 3-β-[(N-benzenesulphonyl/tosyl)-4-(un) substituted anilino]ethyl-4-amino-5-mercapto-4(H)-1,2,4-triazoles (5a-f), with biologically active 'sulphonamide' moiety as the side chain have been prepared. The structures of the newly synthesised compounds have been established on the basis of their spectral data and elemental analysis. All the compounds were evaluated for antimicrobial activities against Escherichia coli, Bacillus cirroflagellosus, Aspergillus niger and Colletotrichum capsici. Most of the compounds investigated exhibited significant antifungal activity against Colletotrichum capsici, even greater than fluconazole, the standard used. Only two compounds 3f (59%) and 5e (67%), have shown moderate antituberculosis activity... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5400892 Fri, 11 Nov 2011 05:00:00 +0100 5400892 http://www.medworm.com/index.php?rid=5400891&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F1%2F111%2F89770 T Patel, K Shah, K Jiwan, Neeta ShrivastavaIndian Journal of Pharmaceutical Sciences 2011 73(1):111-115Physalis minima is an important medicinal plant of Indian System of Medicine. This plant is reported for its diuretic, laxative and antiinflammatory activities. However, the plant is not well scrutinized for its antimicrobial potential. The major chemical constituents reported from the plant are phenolics and alkaloids, which suggest that the plant may turn out to be a potent antiinfective agent. The aim of the study was to find out the antibacterial potential of mature berries of P. minima using streak plate, well diffusion, determination of minimum inhibitory concentration and bioautographic methods against a battery of Gram positive and Gram negative bacterial strains. Results of the s... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5400891 Fri, 11 Nov 2011 05:00:00 +0100 5400891 http://www.medworm.com/index.php?rid=5400890&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F1%2F107%2F89769 C Sitaram, RB Rupakula, BN Reddy, C.S.P SastryIndian Journal of Pharmaceutical Sciences 2011 73(1):107-110High sensitive rapid gas chromatography-mass spectrometry method for the determination of four carcinogenic alkyl methanesulfonates viz. methyl methanesulfonate, ethyl methanesulfonate, isopropyl methanesulfonate and n-butyl methanesulfonate in doxazosin mesylate has been presented by using selective ion monitoring mode. The optimum separation was achieved between methyl methanesulfonate, ethyl methanesulfonate, isopropyl methanesulfonate and n-butyl methanesulfonate on a DB-5 (30 m×0.32 mm×1.0 μm) capillary column under programming temperature. Acetonitrile, water and ammonia (90:9:1 v/v/v) mixture was used as diluent. Various factors involved in th... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5400890 Fri, 11 Nov 2011 05:00:00 +0100 5400890 http://www.medworm.com/index.php?rid=5400889&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F1%2F104%2F89768 SS Das, Monalisha Dey, AK GhoshIndian Journal of Pharmaceutical Sciences 2011 73(1):104-107The aim of the present study was to evaluate the anthelmintic activity of ethanolic and aqueous extract of leaves and bark of Tamarindus indica Linn using Pheretima posthuma and Tubifex tubifex as test worms. The time of paralysis and time of death were studied and the activity was compared with piperazine citrate as reference standard. The alcohol and aqueous extract of bark of Tamarindus indica exhibited significant anthelmintic activity as evidenced by decreased paralyzing time and death time. The results thus support the use of Tamarindus indica as an anthelmintic agent. (Source: Indian Journal of Pharmaceutical Sciences) Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5400889 Fri, 11 Nov 2011 05:00:00 +0100 5400889 http://www.medworm.com/index.php?rid=5400888&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F1%2F101%2F89767 Mymoona Akhter, A Husain, N Akhter, M.S.Y KhanIndian Journal of Pharmaceutical Sciences 2011 73(1):101-104Synthesis of title compounds (4a-j) was carried out by following aminomethylation Mannich reaction. Test compounds were effective in inhibiting edema induced by carrageenan. The percent inhibition obseved was in the range of 25-83.3%. Compound (4c, e, h and j) were also tested for analgesic effect and showed percent protection ranging between 57-65%. All the synthesized compounds were active against E. coli and S. aureus but only compounds (4 b, c, e, i and j) were active against B. subtilis. All these compound were also found active against A. niger. Compound 4j was the most active compound with 83.3% inhibition of edema, 65.35% percent protection and inhib... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5400888 Fri, 11 Nov 2011 05:00:00 +0100 5400888 http://www.medworm.com/index.php?rid=5400887&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F1%2F98%2F89766 Lakshmi S Pillai, Bindu R NairIndian Journal of Pharmaceutical Sciences 2011 73(1):98-100Methanol, aqueous and chloroform extracts of Cleome viscosa and Cleome burmanni were tested for anthelmintic potential against the Indian earthworm Pheritima posthuma. Different concentrations of the extracts ranging from 50-2000 μg/ml were tested and results expressed as time required for paralysis and death of the worms. Piperazine citrate was used as a reference standard and DMSO (1%) as the negative control. The methanol extracts of Cleome viscosa and Cleome burmanni exhibited significant anthelmintic activity. Methanol extract of Cleome viscosa at a concentration of 2000 μg/ml was detected to be the most effective treatment dose. Thin layer chromatography of methanol... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5400887 Fri, 11 Nov 2011 05:00:00 +0100 5400887 http://www.medworm.com/index.php?rid=5400886&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F1%2F92%2F89765 In conclusion, majority of the assayed medicated soaps have satisfactory antibacterial activity; though lack antifungal effect with exception of Linda® liquid soap. The hand washing technique has proved to be inappropriate for evaluation of soaps' antimicrobial efficacy due to presence of the skin microflora. (Source: Indian Journal of Pharmaceutical Sciences) Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5400886 Fri, 11 Nov 2011 05:00:00 +0100 5400886 http://www.medworm.com/index.php?rid=5400885&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F1%2F88%2F89764 M Basanagouda, VB Jadhav, MV Kulkarni, R Nagendra RaoIndian Journal of Pharmaceutical Sciences 2011 73(1):88-92Coumarin-4-acetic acids have been synthesized from various phenols and citric acid under Pechmann cyclisation conditions. All the compounds have been evaluated for antiinflammatory and analgesic activity in acute models. Compounds have also been evaluated for their ulcerogenic potential. Using the computer program, prediction of activity spectra for substances, prediction results and their Pharma Expert software, we have found a correlation between the observed and predicted antiinflammatory activity. (Source: Indian Journal of Pharmaceutical Sciences) Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5400885 Fri, 11 Nov 2011 05:00:00 +0100 5400885 http://www.medworm.com/index.php?rid=5400884&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F1%2F84%2F89763 S Sharma, A Bhandari, VR Choudhary, H Rajpurohit, P KhandelwalIndian Journal of Pharmaceutical Sciences 2011 73(1):84-88A reverse phase high performance liquid chromatography method was developed for simultaneous estimation of nitazoxanide and ofloxacin in tablet formulation. The separation and quantification was achieved by Hiq Sil C 18 V Size 4.6 mm ∅ *250 mm column in isocratic mode, with mobile phase consisting of acetonitrile-methanol-0.4 M citric acid, (60:30:10, v/v/v). Citric acid used to stabilize nitazoxanide and ofloxacin in mobile phase. The mobile phase was pumped at a rate of 0.6 ml/min and the detection was carried out at 304 nm. The retention time of ofloxacin and nitazoxanide was found to be 3.122 and 5.902 min, respectively. The method was validated for linea... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5400884 Fri, 11 Nov 2011 05:00:00 +0100 5400884 http://www.medworm.com/index.php?rid=5400883&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F1%2F79%2F89762 Sonal Desai, Archita Patel, SY GabheIndian Journal of Pharmaceutical Sciences 2011 73(1):79-84A simple isocratic reversed phase high performance liquid chromatography was used to separate three impurities present in the sample of 8-chlorotheophylline. LC-MS was used for the characterization of impurities. Based on mass spectral data, the structures of these impurities were characterized as 3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione (impurity I), 3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione (impurity II) and isomer of 8-chloro-1,3-dimethyl-2,6(3H,1H)-purinedione (impurity III). (Source: Indian Journal of Pharmaceutical Sciences) Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5400883 Fri, 11 Nov 2011 05:00:00 +0100 5400883 http://www.medworm.com/index.php?rid=5400882&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F1%2F76%2F89761 J Parvathi, Aruna KaremungikarIndian Journal of Pharmaceutical Sciences 2011 73(1):76-79Haematological studies in helminthiasis reveal drastic alterations in the white blood cells (leucocytes), and its various components like neutrophils, lymphocytes, monocytes and eosinophils. The use of proper anthelmintic agent, restores normalcy in the infected host. These variations during helminth infections reflect the host defense status in combating the parasitic attack. The present study involves the evaluation of these total and differential haematological alterations, induced in the laboratory mouse Mus musculus, infested with the intestinal helminth, Hymenolepis nana (dwarf tapeworm), and treated with the praziquantel, using an automatic Coulter Counter. (Source: Indian Journal of Pharmaceutic... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5400882 Fri, 11 Nov 2011 05:00:00 +0100 5400882 http://www.medworm.com/index.php?rid=5400881&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F1%2F74%2F89760 R Jain, SK Kashaw, Rishab Jain, P Mishra, DV KohliIndian Journal of Pharmaceutical Sciences 2011 73(1):74-76A simple, accurate and economic spectrophotometric method for the determination of aripiprazole in tablet formulation is proposed. In the present method acidic solution of the aripiprazole formed colored ion-association complexes with bromocresol green, soluble in chloroform. Yellowish orange chromogen showed λmax at 414 nm and obeyed Beer's law in the concentration range of 10-60 μg/ml. Statistical analysis and recovery studies validated the method. The proposed method is rapid, precise and accurate and can be applied for the routine estimation of aripiprazole in the laboratory. (Source: Indian Journal of Pharmaceutical Sciences) Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5400881 Fri, 11 Nov 2011 05:00:00 +0100 5400881 http://www.medworm.com/index.php?rid=5400880&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F1%2F70%2F89759 Madhuri D Game, DM SakarkarIndian Journal of Pharmaceutical Sciences 2011 73(1):70-74Two simple, accurate and precise spectrophotometric methods have been developed for simultaneous determination of nitazoxanide and ofloxacin in tablets. Method I is Q-absorbance ratio method which involves Q-absorbance at isobestic point (306.25 nm) and max (347.5 nm) of nitazoxanide, while method II is two wavelength method, where 244.6 nm and 273.0 nm were selected as 1 and 2 for determination of nitazoxanide and 294.3 nm and 388.1 nm were selected as 3 and 4 for determination of ofloxacin. Both drugs obeyed the Beer's law in the concentration range 2-30 μg/ml,correlation coefficient (r 2 <1). Both methods were validated statistically and recovery studies were carried out to confirm... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5400880 Fri, 11 Nov 2011 05:00:00 +0100 5400880 http://www.medworm.com/index.php?rid=5400879&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F1%2F65%2F89758 P Pattanayak, P Mohapatra, RK Jena, SK PandaIndian Journal of Pharmaceutical Sciences 2011 73(1):65-70Quality assurance of herbal products may be ensured by proper quality control of the herbal ingredients and by means of good manufacturing practice. We have developed a simple scheme for the standardization and authentication of Sulaharan Yoga a poly herbal formulation. Sulaharan Yoga was prepared as per Ayurvedic Formulary of India. In-house and marketed preparation has been standardized on the basis of organoleptic characters, physical characteristics and physico-chemical properties. The set parameters were found to be sufficient to standardize the Sulaharan Yoga and can be used as reference standards for the quality control/ quality assurance study. (Source: Indian Journal of Pharmaceut... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5400879 Fri, 11 Nov 2011 05:00:00 +0100 5400879 http://www.medworm.com/index.php?rid=5400878&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F1%2F57%2F89757 MP Jadhav, Mangal S Nagarsenker, RV Gaikwad, A Samad, Nilima A KshirsagarIndian Journal of Pharmaceutical Sciences 2011 73(1):57-64In the present study, we formulated long circulating liposomes for amphotericin B and characterized them. The formulation was optimized using 2 3 factorial designs. Pegylated liposomal formulation showed favorable results with reference to particle size (247.33±9.60 nm), percent entrapment efficiency (94.55±3.34%). TEM studies revealed that the liposomes were essentially spherical, hollow, and appeared like powder puff structures. From DSC study it was concluded that the pegylated formulation containing Amp B showed better stability and membrane integrity of the formulation. During the stability studies the formulation was found t... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5400878 Fri, 11 Nov 2011 05:00:00 +0100 5400878 http://www.medworm.com/index.php?rid=5400877&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F1%2F46%2F89756 A Porel, Sanjukta Haty, A KunduIndian Journal of Pharmaceutical Sciences 2011 73(1):46-56The aim of the present study was the development and subsequent validation of a simple, precise and stability-indicating reversed phase HPLC method for the simultaneous determination of guaifenesin, terbutaline sulphate and bromhexine hydrochloride in the presence of their potential impurities in a single run. The photolytic as well as hydrolytic impurities were detected as 3,5-dihydroxybenzoic acid, 3,5-dihydroxybenzaldehyde, 1-(3,5-dihydroxyphenyl)-2-[(1,1-dimethylethyl) amino]-ethanone from terbutaline, 2-methoxyphenol and an unknown impurity identified as (2RS)-3-(2-hydroxyphenoxy)-propane-1,2-diol from guaifenesin. The chromatographic separation of all the three active components and their impurit... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5400877 Fri, 11 Nov 2011 05:00:00 +0100 5400877 http://www.medworm.com/index.php?rid=5400876&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F1%2F38%2F89755 Vasantha Janardhan, P Soundararajan, N Vanitha Rani, G Kannan, P Thennarasu, Rosney Ann Chacko, C Uma Maheswara ReddyIndian Journal of Pharmaceutical Sciences 2011 73(1):38-45Malnutrition is widely prevalent among patients on hemodialysis. Malnutrition can be estimated using a fully quantitative scoring system Subjective Global Assessment-Dialysis Malnutrition Score which is simple, reliable and dynamic. The primary objective of the study was to assess the severity of malnutrition in patients with end stage renal disease and undergoing hemodialysis in a tertiary care teaching hospital in Chennai, using Subjective Global Asses sment-Dialysis Malnutrition Score and correlate it with standard indicators of malnutrition like anthropometric and biochemical parameters of the study population by ... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5400876 Fri, 11 Nov 2011 05:00:00 +0100 5400876 http://www.medworm.com/index.php?rid=5400875&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F1%2F30%2F89754 This study discusses efforts made to design drug-delivery system based on superporous hydrogel composite for sustained delivery of ranitidine hydrochloride. The characterization studies involve measurement of apparent density, porosity, swelling studies, mechanical strength studies, and scanning electron microscopy. Scanning electron microscopic images clearly showed the formation of interconnected pores, capillary channels, and the cross-linked sodium carboxymethylcellulose molecules around the peripheries of pores. The prepared system floated and delivered the ranitidine hydrochloride for about 17 h. The release profile of ranitidine hydrochloride was studies by changing the retardant polymer in the system. To ascertain the drug release kinetics, the dissolution profiles were fitted to d... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5400875 Fri, 11 Nov 2011 05:00:00 +0100 5400875 http://www.medworm.com/index.php?rid=5400874&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F1%2F23%2F89753 SV Londhe, RS Deshmukh, SV Mulgund, KS JainIndian Journal of Pharmaceutical Sciences 2011 73(1):23-29A simple, accurate, rapid and precise isocratic reversed-phase high-performance liquid chromatographic method has been developed and validated for simultaneous determination of aspirin, atorvastatin calcium and clopidogrel bisulphate in capsules. The chromatographic separation was carried out on an Inertsil ODS analytical column (150×4.6 mm; 5 μm) with a mixture of acetonitrile:phosphate buffer pH 3.0 adjusted with o-phosphoric acid (50:50, v/v) as mobile phase; at a flow rate of 1.2 ml/min. UV detection was performed at 235 nm. The retention times were 1.89, 6.6 and 19.8 min. for aspirin, atorvastatin calcium and clopidogrel bisulphate, respectively. Calibration plo... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5400874 Fri, 11 Nov 2011 05:00:00 +0100 5400874 http://www.medworm.com/index.php?rid=5400873&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F1%2F17%2F89752 RY Shah, YK AgrawalIndian Journal of Pharmaceutical Sciences 2011 73(1):17-22The paper focuses on the introduction of fiber optics, a fusion of science and engineering and describes the materials generally used for its construction along with the procedure used to design the fibers. It gives an idea of the materials used for the construction along with the pros and cons associated with them and various factors governing the emission of ultraviolet, infrared or visible radiations. The central core revolves around the applications of optical fibers in the medical and biomedical field and extending the use of the same in pharmaceutical industry as probes in quality control and dosage form analysis. (Source: Indian Journal of Pharmaceutical Sciences) Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5400873 Fri, 11 Nov 2011 05:00:00 +0100 5400873 http://www.medworm.com/index.php?rid=5400872&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F1%2F7%2F89751 K Pavani Bharati, U Ram PrashanthIndian Journal of Pharmaceutical Sciences 2011 73(1):7-16Most commonly inherited bleeding disorder, first described in Aland Islands by Erik von Willebrand. It occurs as a result of decrease in plasma levels or defect in von Willebrand factor which is a large multimeric glycoprotein. Monomers of this glycoprotein undergo N-glycosylation to form dimers which get arranged to give multimers. Binding with plasma proteins (especially factor VIII) is the main function of von Willebrand factor. The disease is of two forms: Inherited and acquired forms. Inherited forms are of three major types. They are type 1, type 2, and type 3; in which type 2 is sub-divided into 2A, 2B, 2M, 2N. Type 1 is more prevalent than all other types. Mucocutaneous bleeding is mild in typ... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5400872 Fri, 11 Nov 2011 05:00:00 +0100 5400872 http://www.medworm.com/index.php?rid=5400871&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2011%2F73%2F1%2F1%2F89750 T Arora, AK Mehta, V Joshi, KD Mehta, N Rathor, PK Mediratta, KK SharmaIndian Journal of Pharmaceutical Sciences 2011 73(1):1-6The preclinical studies for drug screening involve the use of animals which is very time consuming and expensive and at times leads to suffering of the used organism. Animal right activists around the world are increasingly opposing the use of animals. This has forced the researchers to find ways to not only decrease the time involved in drug screening procedures but also decrease the number of animals used and also increase the humane care of animals. To fulfill this goal a number of new in vitro techniques have been devised which are called 'Alternatives' or 'Substitutes' for use of animals in research involving drugs. These 'Al... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5400871 Fri, 11 Nov 2011 05:00:00 +0100 5400871 http://www.medworm.com/index.php?rid=5209135&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F6%2F825%2F84609 Madhuri D Game, KB Gabhane, DM SakarkarIndian Journal of Pharmaceutical Sciences 2010 72(6):825-828A simple, accurate and precise spectrophotometric method has been developed for simultaneous estimation of clopidogrel bisulphate and aspirin by employing first order derivative zero crossing method. The first order derivative absorption at 232.5 nm (zero cross point of aspirin) was used for clopidogrel bisulphate and 211.3 nm (zero cross point of clopidogrel bisulphate) for aspirin.Both the drugs obeyed linearity in the concentration range of 5.0 μg/ml to 25.0 μg/ml (correlation coefficient r 2 <1). No interference was found between both determined constituents and those of matrix. The method was validated statistically and recovery studies were carried out to conf... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5209135 Wed, 07 Sep 2011 04:00:00 +0100 5209135 http://www.medworm.com/index.php?rid=5209134&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F6%2F822%2F84607 S Patra, R Sahoo, RK Panda, K Himasankar, BB BarikIndian Journal of Pharmaceutical Sciences 2010 72(6):822-825In the present research work mouth dissolving tablets of domperidone were developed with superdisintegrants like crospovidone, croscarmellose sodium and sodium starch glycollate in various concentrations like 3%, 4% and 6% w/w by direct compression method. All formulations were evaluated for physical characteristics of compressed tablets such as weight variation, hardness, friability, content uniformity, in vitro disintegration time, wetting time and in vitro dissolution study. Among all, the formulation F3 (containing 6% w/w concentration of crospovidone) was considered to be the best formulation, having disintegration time of 9 s, wetting time of 15 s ... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5209134 Wed, 07 Sep 2011 04:00:00 +0100 5209134 http://www.medworm.com/index.php?rid=5209133&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F6%2F818%2F84606 Dolly Rani, PB Khare, PK DantuIndian Journal of Pharmaceutical Sciences 2010 72(6):818-822Plants are an important source of neutraceuticals that have proved to be effective against important microbial infections of humans. Lower plants are gaining importance in this regard. The present study is aimed at investigating the antimicrobial properties of three selected ferns, Psilotum nudum, Nephrolepis biserrata and Nephrolepis cordifolia. The aerial parts of the selected ferns, P. nudum, N. biserrata and N. cordifolia, were fractionated in different solvents. These fractions were concentrated to obtain a powder and were tested against nine bacterial and three fungal strains according to disc diffusion method. The water and ethanol fractions were active against most of the tested bacterial and ... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5209133 Wed, 07 Sep 2011 04:00:00 +0100 5209133 http://www.medworm.com/index.php?rid=5209132&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F6%2F814%2F84605 UK Chhalotiya, HB Patel, KK BhattIndian Journal of Pharmaceutical Sciences 2010 72(6):814-818A simple, specific, accurate, and precise ultra performance liquid chromatographic method was developed and validated for the estimation of venlafaxine hydrochloride in tablet dosage forms. A acquity TM BEH column having C18, 100Χ2.1 mm i.d. in isocratic mode, with mobile phase containing dipotassium hydrogen phosphate: Acetonitrile (30:70 v/v; pH 7.00 with dilute o-phosphoric acid) was used. The flow rate was 0.75 ml/min and effluents were monitored at 227 nm. The retention time of venlafaxine hydrochloride was 0.548 min. The method was validated for specificity, linearity, accuracy, precision, limit of quantification, limit of detection, robustness and solution stability. Limit of det... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5209132 Wed, 07 Sep 2011 04:00:00 +0100 5209132 http://www.medworm.com/index.php?rid=5209131&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F6%2F809%2F84604 GA Shabir, TK BradshawIndian Journal of Pharmaceutical Sciences 2010 72(6):809-814A reversed-phase liquid chromatographic method for the determination of 1,7,7-trimethyl-bicyclo(2,2,1)heptan-2-one in a cream formulation is developed and validated. The separation was achieved using an isocratic mobile phase, on a Lichrosorb C8 column. The calibration curve is linear (r 2 = 0.9999) from 25-175% of the analytical concentration of 1.0 mg/ml. The mean percent standard deviation values for intra-day and inter-day precision studies were <1%. The recovery ranges 99.80-100.06% from a cream formulation. The method can be used reliably in quality control for the analysis of bulk cream samples and final product release. (Source: Indian Journal of Pharmaceutical Sciences) Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5209131 Wed, 07 Sep 2011 04:00:00 +0100 5209131 http://www.medworm.com/index.php?rid=5209130&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F6%2F806%2F84603 P Selvam, N Murugesh, M Chandramohan, C Pannecouque, E DE ClercqIndian Journal of Pharmaceutical Sciences 2010 72(6):806-809A series of novel 2,3-disubstitutedquinazolin-4(3H)-ones have been synthesized by condensation of 2-substituted benzo[1,3]oxazine-4-ones and anthranilic acid. Synthesized compounds were evaluated for in vitro antiviral activity against HIV, HSV and vaccinia viruses. 5-Bromo-2-(6-bromo-4-oxo-2-phenyl-4H-quinazolin-3-yl)-benzoic acid (MBR2) exhibited distinct antiviral activity against Herpes simplex and vaccinia viruses. (Source: Indian Journal of Pharmaceutical Sciences) Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5209130 Wed, 07 Sep 2011 04:00:00 +0100 5209130 http://www.medworm.com/index.php?rid=5209129&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F6%2F801%2F84602 Sweety , S Kumar, K Nepali, S Sapra, OP Suri, KL Dhar, GS Sarma, AK SaxenaIndian Journal of Pharmaceutical Sciences 2010 72(6):801-806Chalcones and their synthetic analogues appear to have the same binding site of tubuline as phenstatin, combretastatin steganacin and podophylotoxin and are therefore capable to inhibit cancer cell proliferation. The phenyl rings with appropriate substitutions maintain a fixed distance between two centers of aryl rings. The two aromatic rings in these molecules are arranged like the two wings of a butterfly having certain dihedral angle between them, therefore a "butterfly model" is proposed an important structural feature responsible for their antitubulin activity. In this sequence a series of chalcones were synthesized and evaluated for in vitro ... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5209129 Wed, 07 Sep 2011 04:00:00 +0100 5209129 http://www.medworm.com/index.php?rid=5209128&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F6%2F798%2F84601 B Syama Sundar, A SuneethaIndian Journal of Pharmaceutical Sciences 2010 72(6):798-801A new, simple high performance thin layer chromatographic method has been proposed for the determination of rizatriptan benzoate in a tablet dosage form. The drug was separated on aluminum plates precoated with silica gel 60 F-- 254 with dichloromethane-acetone-acetic acid 3:2:0.2(v/v/v) as mobilephase. Quantitative analysis was performed by densitometric scanning at 230 nm. The method was validated for linearity, accuracy, precision and robustness. The calibration plot was linear over the range 200-700 ng/band for rizatriptan benzoate. The method was successfully applied to the analysis of drug in bulk and marketed tablets. (Source: Indian Journal of Pharmaceutical Sciences) Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5209128 Wed, 07 Sep 2011 04:00:00 +0100 5209128 http://www.medworm.com/index.php?rid=5209127&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F6%2F795%2F84600 This study assess the antioxidant capacity of Tinospora cordifolia stem methanol extract in daily oral administration of 500 mg/kg of body weight for 40 days in alloxan induced diabetic rats. The erythrocytes membrane lipid peroxide and catalase activity was increased where as the activities of superoxide dismutase, glutathione peroxidase were found to be decreased significantly (P<0.01) in alloxan-induced diabetic rats. The levels of lipid peroxide in liver of diabetic rats increased significantly (P<0.01) and catalase, superoxide dismutase, glutathione peroxidase in liver was significantly decreased in alloxan-induced diabetic rats, when compared to normal rats. After treatment of methanol Tinospora cordifolia stem extract brings back to normal (P<0.01) in the erythrocytes membr... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5209127 Wed, 07 Sep 2011 04:00:00 +0100 5209127 http://www.medworm.com/index.php?rid=5209126&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F6%2F792%2F84599 SA Shah, RB Vyas, BA Vyas, NR Maniyar, RS Chauhan, DR ShahIndian Journal of Pharmaceutical Sciences 2010 72(6):792-794A simple, accurate, rapid, specific and reproducible UV spectrophotometric method was developed for estimation of content uniformity of atenolol and losartan potassium in its combined tablet dosage form. The method involves formation and solving the simultaneous equation using 226.4 and 254 nm as two wavelengths for atenolol and losartan, respectively. Developed method was employed to determine the atenolol and losartan content in ten individual tablet units of five market formulations. Methanol was used as solvent. The method was validated. From the results, it was concluded that all brands are within the content uniformity limit, 85-115%. (Source: Indian Journal of... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5209126 Wed, 07 Sep 2011 04:00:00 +0100 5209126 http://www.medworm.com/index.php?rid=5209125&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F6%2F787%2F84597 S Ray, J Pramanik, M Bhattacharyya, S TodiIndian Journal of Pharmaceutical Sciences 2010 72(6):787-792The primary aim of this study is to identify and analyze the importance of adverse drug reaction due to drug-drug interaction as a contributing factor towards drug safety. Patients more than 18 years of age admitted in multidisciplinary intensive care unit of a tertiary care hospital were included in this study. Patients who stayed less than 48 h and patients in whom all treatment modalities have been withdrawn and were on comfort measures only (no drugs were prescribed), were excluded. All the drugs that were given during intensive care unit stay were checked for presence of potential interactions which led to adverse drug reaction. Drug-drug interactions that were detected clinically or ... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5209125 Wed, 07 Sep 2011 04:00:00 +0100 5209125 http://www.medworm.com/index.php?rid=5209124&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F6%2F785%2F84596 Richa Kumari, PP Dash, VK Lal, A Mishra, PN MurthyIndian Journal of Pharmaceutical Sciences 2010 72(6):785-787A rapid and sensitive reverse phase RP-HPLC method is proposed for the estimation of tamsulosin hydrochloride in tablets. Tamsulosin hydrochloride was chromatographed on a reverse phase C18 column with a mobile phase consisting of acetonitrile and water in the ratio of 50:50 v/v. The mobile phase was pumped at a flow rate of 1.5 ml/min. The eluents were monitored at 214 nm. The retention time of the drug was 1.7 min. With this method, linearity was observed between area under curve and concentration of tamsulosin hydrochloride in the injected solution, in the range of 5 to 100 μg/ml. The method was found to be applicable for analysis of the drug in tablets. The results ... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5209124 Wed, 07 Sep 2011 04:00:00 +0100 5209124 http://www.medworm.com/index.php?rid=5209123&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F6%2F781%2F84594 B Shrivastava, US Baghel, M SahuIndian Journal of Pharmaceutical Sciences 2010 72(6):781-784A selective and sensitive, stability-indicating reverse phase high performance liquid chromatography method has been first developed and validated for the estimation of miglitol in bulk and tablet dosages form. Samples were separated on a prepacked, Inertsil amino C 18 column (150Χ4.6 mm i.d.) using a mobile phase comprised of acetonitrile and monobasic sodium phosphate pH 7.5 (80:20, v/v) delivered at 1.5 ml/min flow rate. Detection was performed on a SPD-20A prominence UV/Vis detector at 220 nm. The retention time for miglitol was 13.93±0.0367. The method was validated in terms of linearity, precision, accuracy, ruggedness, and specificity, limit of detection and limit of q... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5209123 Wed, 07 Sep 2011 04:00:00 +0100 5209123 http://www.medworm.com/index.php?rid=5209122&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F6%2F778%2F84593 Vijayalaxmi Amareshwar, SJ Patil, NM GoudgaonIndian Journal of Pharmaceutical Sciences 2010 72(6):778-781A pyrimidne nucleobase, 5-phenylthio-2,4-bisbenzyloxypyrimidine and its analogs were synthesized and scanned for in vitro antifungal activity using cup-plate and macrobroth dilution method against Candida albicans, Aspergillus niger, Aspergillus flavus and Aspergllus fumigatus. In the cup-plate method, 5-phenylthio-2,4-bisbenzyloxypyrimidine showed very good antifungal activity compared to clotrimazole at the concentrations of 100 and 1000 μg/ml and in the macrobroth dilution method, it showed comparable activity with respect to standard drugs fluconazole and itraconaole. In vivo antifungal activity of 5-phenylthio-2,4-bisbenzyloxypyrimidine at the dose levels of 10 and 30 m... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5209122 Wed, 07 Sep 2011 04:00:00 +0100 5209122 http://www.medworm.com/index.php?rid=5209121&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F6%2F775%2F84592 NK Srivastava, AK SrivastavaIndian Journal of Pharmaceutical Sciences 2010 72(6):775-778Shoot biomass production, alkaloid content and composition as influence by cadmium, manganese, nickel and lead at uniform dose of 5 mM were investigated in Catharanthus roseus plants grown in sand culture. Treatment with Mn, Ni, and Pb significantly enhanced total root alkaloid accumulation. Cd and Ni treatment resulted in two-fold where as Pb treatment resulted in three fold increase in serpentine content of roots. The non-significant affect on biomass suggests that plants can withstand metal stress at the level tested with positive affect on root alkaloid content. (Source: Indian Journal of Pharmaceutical Sciences) Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5209121 Wed, 07 Sep 2011 04:00:00 +0100 5209121 http://www.medworm.com/index.php?rid=5209120&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F6%2F766%2F84590 AB Jindal, MN Wasnik, Hema A NairIndian Journal of Pharmaceutical Sciences 2010 72(6):766-774Modification of polymers by covalent attachment of thiol bearing pendant groups is reported to impart many beneficial properties to them. Hence in the present study, sodium alginate-cysteine conjugate was synthesized by carbodiimide mediated coupling under varying reaction conditions and the derivatives characterized for thiol content. The thiolated alginate species synthesized had bound thiol content ranging from 247.8±11.03-324.54±10.107 ΅mol/g of polymer depending on the reaction conditions. Matrix tablets based on sodium alginate-cysteine conjugate and native sodium alginate containing tramadol hydrochloride as a model drug were prepared and mucoadhesive stre... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5209120 Wed, 07 Sep 2011 04:00:00 +0100 5209120 http://www.medworm.com/index.php?rid=5209119&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F6%2F759%2F84589 NP Yadav, D Chanda, SK Chattopadhyay, AK Gupta, A PalIndian Journal of Pharmaceutical Sciences 2010 72(6):759-765The aim of the present work was to investigate the in vivo hepatoprotective potential of coumarinolignoids (cleomiscosins A, B, and C) isolated from the seeds of C. viscosa. The study was performed against CCl 4 -induced hepatotoxicity in albino rats. Rats were divided into four groups. The animals of group I served as normal and was given only vehicle. Group II served as toxin control and administered with CCl 4 (50% solution liquid paraffin, 2 ml/kg intraperitoneally). The animals of group III received coumarinolignoids (50 mg/kg) for six days orally as well as CCl 4 (2 ml/kg) on 4 th day i.p. Similarly animals of group IV received silymarin (50 mg/kg) for six days oral... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5209119 Wed, 07 Sep 2011 04:00:00 +0100 5209119 http://www.medworm.com/index.php?rid=5209118&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F6%2F753%2F84587 Unnati M Shah, SM Patel, PH Patel, L Hingorani, RB JadhavIndian Journal of Pharmaceutical Sciences 2010 72(6):753-758Cissus quadrangularis L. is a promising remedy prescribed in the ancient Ayurvedic literature for bone fracture healing properties. As this activity has been extensively investigated and well established, a range of formulations containing C. quadrangularis has been marketed. This work reports the development and validation of a reliable RP-HPLC method for the analysis of phytosterols in the various extracts of the plant. The proposed method utilizes a Cosmosil C 8 column (250 ΄ 4.6 mm) with a compatible Phenomenex C 8 guard column with isocratic elution of acetonitrile and water (95:5 v/v) at 25΀. An effluent flow rate of 2 ml/min and UV detection at... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5209118 Wed, 07 Sep 2011 04:00:00 +0100 5209118 http://www.medworm.com/index.php?rid=5209117&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F6%2F745%2F84585 GA Kurian, J PaddikkalaIndian Journal of Pharmaceutical Sciences 2010 72(6):745-752The present study investigate the protective effect of aqueous root extract of Desmodium gangeticum in preserving mitochondrial and sarcoplasmic ATPase during ischemia reperfusion injury. The isolated rat hearts in both drug and control group were subjected to warm ischemia (37°), followed by reperfusion with the Langendorff perfusion system. The aqueous root extract of Desmodium gangeticum (L) at a dose of 50 mg/kg body weight was found to be effective in the rat heart for the management of ischemic reperfusion injury. Physiological parameters were significantly (P<0.05) improved in drug treated rat hearts. Creatine phosphokinase in coronary perfusate found to be declined. Moreover, sarcoplas... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5209117 Wed, 07 Sep 2011 04:00:00 +0100 5209117 http://www.medworm.com/index.php?rid=5209116&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F6%2F738%2F84583 BK Satishbabu, VR Sandeep, RB Ravi, R ShrutinagIndian Journal of Pharmaceutical Sciences 2010 72(6):738-744A multiple unit oral floating drug delivery system of famotidine was developed to prolong gastric residence time, target stomach mucosa and increase drug bioavailability. Drug and polymer compatibility was studied by subjecting physical mixtures of drug and polymers to differential scanning calorimetry. Cod liver oil entrapped calcium alginate beads containing famotidine, capable of floating in the gastric condition were formulated and evaluated. The gel beads were prepared by emulsion gelation method by employing sodium alginate alone and mixture of sodium alginate and hydrophilic copolymers such as carbopol 934P and hydroxypropylmethylcellulose K15M grade in three different ratios. ... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5209116 Wed, 07 Sep 2011 04:00:00 +0100 5209116 http://www.medworm.com/index.php?rid=5209115&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F6%2F732%2F84582 BD Kevadiya, HA Patel, GV Joshi, S.H.R. Abdi, HC BajajIndian Journal of Pharmaceutical Sciences 2010 72(6):732-737Diclofenac sodium and alginate was intercalated into montmorillonite to form uniform sized beads by gelation method. The structure and surface morphology of the synthesized composite beads were characterized by powdered X-ray diffraction, Fourier transform infrared spectroscopy, thermo gravimetric analysis and scanning electron microscopy. Diclofenac release kinetics of the composite in simulated intestinal fluid medium (pH 7.4) and effect of montmorillonite content on the in vitro release of diclofenac from diclofenac-montmorillonite-alginate composites bead was investigated by UV/Vis spectrophotometer. Diclofenac encapsulation efficiency in the montmorillonite-alginate compos... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5209115 Wed, 07 Sep 2011 04:00:00 +0100 5209115 http://www.medworm.com/index.php?rid=5209114&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F6%2F726%2F84581 P Loya, MN SarafIndian Journal of Pharmaceutical Sciences 2010 72(6):726-731An analytical method based on high-performance liquid chromatography with ultraviolet detection (245 nm) was developed for the determination of actarit in human plasma. Coumarin was used as an internal standard. Chromatographic separation was achieved with a C8 column using a mobile phase of methanol: 1% acetic acid (50-50, v/v) with a flow rate of 1.0 ml/min. The calibration curve was linear over the range of 0.1-4.0 μg/ml (r 2 > 0.99) and the lower limit of quantification was 0.1 μg/ml. The method was validated for sensitivity, accuracy, precision, recovery and stability. The method was used to determine the concentration-time profiles of actarit in the plasma following oral admi... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5209114 Wed, 07 Sep 2011 04:00:00 +0100 5209114 http://www.medworm.com/index.php?rid=5209113&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F6%2F719%2F84580 R Surendra Kumar, A Idhayadhulla, A Jamal Abdul Nasser, S Kavimani, S IndumathyIndian Journal of Pharmaceutical Sciences 2010 72(6):719-725A series of 1,4-dihydropyridine derivatives (1a-g) were prepared from three compounds condensation of Hantzsch synthesis. A new series of 2,2'-{[4-(aryl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl]dicarbonyl}dihydrazinecarbothioamide (2a-g) were prepared from compounds diethyl 4-(aryl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (1a-g) reacted with thiosemicarbazide to give the corresponding compounds (2a-g) by hydrazinolysis method. The synthesized compounds were confirmed by IR, 1HNMR, 13CNMR, mass spectral and elemental analyses. The newly synthesized compounds (2a-g) were screened for anticonvulsant activity against in swiss albino rat.... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5209113 Wed, 07 Sep 2011 04:00:00 +0100 5209113 http://www.medworm.com/index.php?rid=5209112&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F6%2F710%2F84579 MA Saleem, Sumanji Bala, Liyakat , A AeajazIndian Journal of Pharmaceutical Sciences 2010 72(6):710-718The ability of β-cyclodextrin, hydroxypropyl-β-cyclodextrin, polyvinyl pyrrolidone and urea to influence the percutaneous absorption of meloxicam through isolated rat skin was evaluated. Carrier complex were prepared by kneading method in 1:1 and 1:2 in molar ratios for β-cyclodextrin and hydroxypropyl-β-cyclodextrin and in 1:1, 1:3 and 1:5 in weight ratios for polyvinyl pyrrolidone and urea. The complexes were characterized by IR, DSC and evaluated for solubility, dissolution and skin permeability. The solubility, dissolution and permeability of meloxicam were enhanced by using the carriers. The influence of cyclodextrins, polyvinyl pyrroli... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5209112 Wed, 07 Sep 2011 04:00:00 +0100 5209112 http://www.medworm.com/index.php?rid=5209111&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F6%2F704%2F84578 SD Javeer, Reshma Pandit, SP Jain, Purnima AminIndian Journal of Pharmaceutical Sciences 2010 72(6):704-709Trimetazidine dihydrochloride, a cellular antiischemic agent indicated in the management and prophylaxis of angina pectoris is given as 20 mg thrice daily in the conventional dosage regimen. The purpose of the present study was to formulate and evaluate twice a day extended release tablets containing 30 mg trimetazidine dihydrochloride. The method developed to formulate these extended release tablets was melt congealing followed by wet granulation which exhibited uniform sustained release action and overcame the drawbacks of multidosing. The formulation was developed with Methocel® K100M and stearic acid as release retardant. (Source: Indian Journal of Pharmaceutical Scien... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5209111 Wed, 07 Sep 2011 04:00:00 +0100 5209111 http://www.medworm.com/index.php?rid=5209110&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F6%2F697%2F84577 Purnima Ashok, BC Koti, A.H.M. Thippeswamy, VP Tikare, P Dabadi, A.H.M. ViswanathaswamyIndian Journal of Pharmaceutical Sciences 2010 72(6):697-703In the present study petroleum ether and alcoholic extracts of Centratherum anthelminticum (L) Kuntze seed (100 mg and 200 mg/kg p.o.) were evaluated for antiinflammatory activity in acute and subacute models of inflammation. It was found that both petroleum ether and alcoholic extracts showed significant reduction in paw oedema in carrageenan-induced model. In subchronic inflammatory phase both extracts provoked a significant reduction of transudation phase and too little extent proliferative phase when tested in cotton pellet-induced granuloma model. Both the extracts also reduced alkaline phosphatase activity in serum. The histopathology of g... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5209110 Wed, 07 Sep 2011 04:00:00 +0100 5209110 http://www.medworm.com/index.php?rid=5209109&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F6%2F689%2F84576 H Rajpurohit, P Sharma, S Sharma, A BhandariIndian Journal of Pharmaceutical Sciences 2010 72(6):689-696The colon targeted drug delivery has a number of important implications in the field of pharmacotherapy. Oral colon targeted drug delivery systems have recently gained importance for delivering a variety of therapeutic agents for both local and systemic administration. Targeting of drugs to the colon via oral administration protect the drug from degradation or release in the stomach and small intestine. It also ensures abrupt or controlled release of the drug in the proximal colon. Various drug delivery systems have been designed that deliver the drug quantitatively to the colon and then trigger the release of drug. This review will cover different types of polymers which can be used in ... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5209109 Wed, 07 Sep 2011 04:00:00 +0100 5209109 http://www.medworm.com/index.php?rid=5209108&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F6%2F675%2F84575 RK Khar, GK Jain, MH Warsi, N Mallick, S Akhter, SA Pathan, FJ AhmadIndian Journal of Pharmaceutical Sciences 2010 72(6):675-688Nucleic acid-based therapeutics have gained a lot of interest for the treatment of diverse ophthalmic pathologies. The first to enter in clinic has been an oligonucleotide, Vitravene® for the treatment of cytomegalovirus infection. More recently, research on aptamers for the treatment of age related macular degeneration has led to the development of Macugen® . Despite intense potential, effective ocular delivery of nucleic acids is a major challenge since therapeutic targets for nucleic acid-based drugs are mainly located in the posterior eye segment, requiring repeated invasive administration. Of late, nanotechnology-based nano-vectors hav... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=5209108 Wed, 07 Sep 2011 04:00:00 +0100 5209108 http://www.medworm.com/index.php?rid=4659504&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F5%2F671%2F78546 PB RathiIndian Journal of Pharmaceutical Sciences 2010 72(5):671-674Satranidazole, a potent broad spectrum antiprotozoal, is a poorly water-soluble drug and has low bioavailability on oral administration. One of the important methods to improve the solubility and bioavailability of a less water-soluble drug is by the use of cosolvents. The solubility enhancement produced by binary blends with a cosolvent (dioxane) was studied against the solubility parameter of solvent blends (d1 ) to evaluate the solubility parameter of drug (d2 ). Solubility parameter of drug (d2 ) was evaluated in blends of dioxane-water system. The results obtained were compared with the d2 values obtained using Molar Volume Method and Fedor's Group Substitution Method. The binary blend water-dioxane (10:90) gav... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4659504 Wed, 30 Mar 2011 23:00:00 +0100 4659504 http://www.medworm.com/index.php?rid=4659503&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F5%2F667%2F78545 Sunitha Seerapu, BP SrinivasanIndian Journal of Pharmaceutical Sciences 2010 72(5):667-671A simple, sensitive, precise and robust reverse-phase high-performance liquid chromatographic method for analysis of ivabradine hydrochloride in pharmaceutical formulations was developed and validated as per ICH guidelines. The separation was performed on SS Wakosil C18AR, 250Χ4.6 mm, 5 μm column with methanol:25 mM phosphate buffer (60:40 v/v), adjusted to pH 6.5 with orthophosphoric acid, added drop wise, as mobile phase. A well defined chromatographic peak of Ivabradine hydrochloride was exhibited with a retention time of 6.55±0.05 min and tailing factor of 1.14 at the flow rate of 0.8 ml/min and at ambient temperature, when monitored at 285 nm. The linear regres... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4659503 Wed, 30 Mar 2011 23:00:00 +0100 4659503 http://www.medworm.com/index.php?rid=4659502&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F5%2F663%2F78544 PS Gatne, CL Viswanathan, Premlata K Ambre, Aarti JuvekarIndian Journal of Pharmaceutical Sciences 2010 72(5):663-667Eight novel 1-(substituted acetyl)-4-(10-bromo-8-chloro-5,6-dihydro-11H-benzo[5,6] cyclohepta [1,2-b] pyridine-11-ylidene)piperidines were designed by incorporating zinc binding groups to enhance activity. The designed molecules were synthesized and were evaluated for antitumor activity in vitro in five cell lines and for farnesyl protein transferase inhibition. Test compounds (6a-h) exhibited antitumor activity in most of the cell lines but were less potent than adriamycin. Compound 6e was most active with IC 50 values of <15 μM in two cell lines tested. Test compounds also exhibited potent FPT inhibitory activity and 6c was most potent with IC 50 value of &l... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4659502 Wed, 30 Mar 2011 23:00:00 +0100 4659502 http://www.medworm.com/index.php?rid=4659501&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F5%2F659%2F78543 B Yadav, A Bajaj, M Saxena, AK SaxenaIndian Journal of Pharmaceutical Sciences 2010 72(5):659-663Withania somnifera Dunal know as Ashwagandha belong Solanaceae family. It is extensively used in most of the Indian herbal pharmaceuticals and nutraceuticals. The current study, evaluate in vitro cytotoxicity in 50% ethanol extract of root, stem and leaves of Withania somnifera against five human cancer cell lines of four different tissues i.e. PC-3, DU-145 (prostrate), HCT-15 (colon), A-549 (lung) and IMR-32 (neuroblastoma). Root, stem and leaves extracts showed cytotoxicity activity ranging 0-98% depending on the cell lines but maximum activity was found in 50% ethanol extract of leaves of Withania somnifera. Ethanol extract of leaves obtained from treatments T2, T3, T4 a... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4659501 Wed, 30 Mar 2011 23:00:00 +0100 4659501 http://www.medworm.com/index.php?rid=4659500&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F5%2F657%2F78542 Supriya Agnihotri, S WakodeIndian Journal of Pharmaceutical Sciences 2010 72(5):657-659Greater cardamom (Amomum subulatum Roxb. Zingiberaceae) commonly known as "Bari ilaichi" is a well known plant used in Ayurvedic and Unani medicine. It has been used for the treatment of various diseases and disorders like gastric ulcer. Therefore antimicrobial activity of petroleum ether, methanol and aqueous extracts from leaves and roots, essential oil and isolated vasicine from A. vasica were tested against various microorganisms. Antimicrobial activity was done by disc diffusion method. The zone of inhibition observed was compared with that of standard drugs, ciprofloxacin and fluconazole. Minimum inhibitory concentration was determined against microorganisms used in the study. The results... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4659500 Wed, 30 Mar 2011 23:00:00 +0100 4659500 http://www.medworm.com/index.php?rid=4659499&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F5%2F655%2F78541 AK Verma, RR SinghIndian Journal of Pharmaceutical Sciences 2010 72(5):655-657Evaluation of an ethyl methane sulphonate-induced dwarf mutant of Catharanthus roseus (L.) G. Don revealed that the mutant exhibited marked variation in morphometric parameters. The in vitro antibacterial activity of the aqueous and alcoholic leaf extracts of the mutant and control plants was investigated against medically important bacteria. The mutant leaf extracts showed enhanced antibacterial activity against all the tested bacteria except Bacillus subtilis. (Source: Indian Journal of Pharmaceutical Sciences) Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4659499 Wed, 30 Mar 2011 23:00:00 +0100 4659499 http://www.medworm.com/index.php?rid=4659498&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F5%2F652%2F78540 Shilpa Kawarkhe, SS PoddarIndian Journal of Pharmaceutical Sciences 2010 72(5):652-655A mucoadhesive drug delivery system for local delivery of metronidazole through vaginal route was formulated. Films were prepared by solvent evaporation method using various compositions of Carbopol, hydroxypropylmethylcellulose, chitosan, Polyox and propylene glycol. The films were evaluated for their weight, thickness, surface pH, folding endurance, mechanical, drug content uniformity, in vitro drug release, swelling, gelling and mucoadhesion property. All the films possess satisfactory film characteristics. Films made of Polyox found to possess acceptable, physicochemical, mechanical, gelling and mucoadhesion property for delivery of metronidazole. (Source: Indian Journal of Pharmaceutical Sciences) Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4659498 Wed, 30 Mar 2011 23:00:00 +0100 4659498 http://www.medworm.com/index.php?rid=4659497&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F5%2F649%2F78539 RK Maheshwari, M Saxena, M Gahlot, R Chaki, M Kinariwala, Y JagwaniIndian Journal of Pharmaceutical Sciences 2010 72(5):649-651Highly concentrated aqueous solutions of various hydrotropic agents like sodium benzoate, sodium salicylate, sodium acetate, sodium citrate, nicotinamide and sodium ascorbate have been observed to enhance aqueous solubilities of a large number of poorly water-soluble drugs. In the present investigation hydrotropic solubilization technique has been employed to solubilize poorly water-soluble aspirin (analgesic and antipyretic drug) by 0.5 M ibuprofen sodium solution to carry out titrimetric analysis of aspirin in tablet dosage form. Results of analysis by proposed method and Phamacopoeial method are very comparable. Proposed method is new, rapid, simple, accurate, a... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4659497 Wed, 30 Mar 2011 23:00:00 +0100 4659497 http://www.medworm.com/index.php?rid=4659496&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F5%2F644%2F78538 V Suseela, VK Gopalakrishnan, Sumam VargheseIndian Journal of Pharmaceutical Sciences 2010 72(5):644-649Antioxidant potential of fruits of Artemisia nilagirica was studied using different in vitro models like 1,1-diphenyl-2-picryl hydrazyl, 2,2-azinobis-(3-ethylbenzothizoline-6-sulphonate), nitric oxide, superoxide, hydroxyl radical and lipid peroxidation. Both the ethanol and aqueous extracts of A. nilagirica fruits at 500 μg/ml showed maximum scavenging activity (89.33% and 89.14%) in quenching 1,1-diphenyl-2-picryl hydrazyl radical. The ethanol extract showed better scavenging activity (69.78%) of 1,1-diphenyl-2-picryl hydrazyl radical followed by the scavenging of nitric oxide radical (73.25%) compared to aqueous extract. In contrast, hydroxyl an... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4659496 Wed, 30 Mar 2011 23:00:00 +0100 4659496 http://www.medworm.com/index.php?rid=4659495&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F5%2F641%2F78537 KS Nagarsekar, MS Nagarsenker, SR KulkarniIndian Journal of Pharmaceutical Sciences 2010 72(5):641-643Supercritical fluid extract of leaves of Vitex negundo was tested for its antimicrobial potential and was compared with that of ethanol extract, ether extract and hydrodistilled oil of leaves. The chemical constituents of extracts were studied by chromatographic techniques. Extracts were evaluated for antimicrobial potential against bacterial strains like Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and yeast Candida albicans. Extracts showed prominent antibacterial activity against Bacillus subtilis and Staphylococcus aureus. Supercritical fluid extract exhibited good antibacterial potential. (Source: Indian Journal of Pharmaceutical Sciences) Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4659495 Wed, 30 Mar 2011 23:00:00 +0100 4659495 http://www.medworm.com/index.php?rid=4659494&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F5%2F637%2F78536 The objective of the present investigation was to develop a parenteral microemulsion delivering artemether, a hydrophobic antimalarial drug and to evaluate antimalarial activity of the microemulsion in comparison to the marketed oily injection of artemether (Larither® ). The microemulsion was evaluated for various parameters such as globule size, ability to withstand centrifugation and freeze-thaw cycling and effect of sterilization method on the drug content and globule size. The in vivo antimalarial activity of the microemulsion was evaluated in P. berghei infected mice in comparison to the Larither; . The stability of the microemulsion was evaluated at 5º for 1 month. The microemulsion exhibited globule size of 113 nm and it could successfully withsta... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4659494 Wed, 30 Mar 2011 23:00:00 +0100 4659494 http://www.medworm.com/index.php?rid=4659493&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F5%2F632%2F78535 VS Velingkar, DR Jain, DC AhireIndian Journal of Pharmaceutical Sciences 2010 72(5):632-636Mutual prodrugs of some antiinflammatory agents were synthesized with the aim of improving the therapeutic index through prevention of gastrointestinal complications and to check the efficiency of release of the parent drug in presence of spacer. These mutual prodrugs were synthesized by direct condensation method using dicyclohexyl carbodiimide as a coupling agent and glycine as a spacer. The title compounds were characterized by spectral techniques and the release of the parent drug from mutual prodrug was studied in two different non-enzymatic buffer solutions at pH 1.2, pH 7.4 and in 80% human plasma. All mutual prodrugs exhibited encouraging hydrolysis profile in 80% human plasma. ... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4659493 Wed, 30 Mar 2011 23:00:00 +0100 4659493 http://www.medworm.com/index.php?rid=4659492&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F5%2F629%2F78534 A Suneetha, B SyamasundarIndian Journal of Pharmaceutical Sciences 2010 72(5):629-632A new, simple, precise and accurate high performance thin layer chromatographic method has been proposed for the determination of almotriptan malate in a tablet dosage form. The drug was separated on aluminum plates precoated with silica gel 60 GF 254 with butanol:acetic acid:water (3:1:1) was used as mobilephase. Quantitative analysis was performed by densitometric scanning at 300 nm. The method was validated for linearity, accuracy, precision and robustness. The calibration plot was linear over the range of 100-700 ng/band for almotriptan malate. The method was successfully applied to the analysis of drug in a pharmaceutical dosage form. (Source: Indian Journal of Pharmaceutical Sciences) Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4659492 Wed, 30 Mar 2011 23:00:00 +0100 4659492 http://www.medworm.com/index.php?rid=4659491&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F5%2F625%2F78533 In conclusion, in situ single pass intestinal perfusion can be used effectively to study intestinal permeability as well as site of intestinal absorption of compounds in rats. (Source: Indian Journal of Pharmaceutical Sciences) Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4659491 Wed, 30 Mar 2011 23:00:00 +0100 4659491 http://www.medworm.com/index.php?rid=4659490&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F5%2F621%2F78532 This study reports one another not widely reported property of the plant, immunomodulatory activity, which has been proved using simple techniques like the macrophage activity testing, carbon clearance test and mast cell de-granulation assay. (Source: Indian Journal of Pharmaceutical Sciences) Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4659490 Wed, 30 Mar 2011 23:00:00 +0100 4659490 http://www.medworm.com/index.php?rid=4659489&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F5%2F613%2F78531 NB Patel, HR PatelIndian Journal of Pharmaceutical Sciences 2010 72(5):613-620A novel series of chalcones, pyrimidines and imidazolinone is described; chalcones (4a-o) were prepared from the lead molecule 4-[2-(5-ethylpyridin-2-yl)ethoxy]benzaldehyde. Pyrimidine (5a-o) derivatives were prepared from the reaction of chalcones and guanidine nitrate in alkali media. Imidazolinones (6a-o) were synthesized from reaction of pyrimidine and oxazolone derivatives (prepared by Erlenmeyer azlactone synthesis). The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR, 1 H and 13 C NMR spectral data. All the products were screened against different strains of bacteria and fungi. Most of these compounds showed better inhibitory activity in comparison to the standa... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4659489 Wed, 30 Mar 2011 23:00:00 +0100 4659489 http://www.medworm.com/index.php?rid=4659488&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F5%2F607%2F78529 Bhawani Singh, A Maheshwari, G Dak, K Sharma, GL TalesaraIndian Journal of Pharmaceutical Sciences 2010 72(5):607-612Thiazolidin-4-one fused pyrimidines, [1,5]-benzodiazepines and their oxygen substituted hydroxylamine derivatives have been screened for antibacterial, antifungal and antimalarial activity. Bacillus subtilis, Escherichia coli, Proteus mirabilis and Salmonella typhi were used for antibacterial screening. Aspergillus fumigatus and Candida albicans were used for antifungal screening and Plasmodium species were used for antimalarial screening. The antibacterial and antifungal activities are expressed in terms of zone of inhibition and antimalarial activity is expressed in IC 50 value. Fifteen compounds 2Xa, 2Xb, 2Xc, 2Xs, 3IV, 3Va, 3Vc, 3VIIIa, 3VIIIh, 3IXa, 3IXb, 3IXc, 3Xa, 4IX... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4659488 Wed, 30 Mar 2011 23:00:00 +0100 4659488 http://www.medworm.com/index.php?rid=4659487&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F5%2F599%2F78527 AA Kharia, SN Hiremath, AK Singhai, LK Omray, SK JainIndian Journal of Pharmaceutical Sciences 2010 72(5):599-606The purpose of the present work was to design and optimize floating drug delivery systems of acyclovir using psyllium husk and hydroxypropylmethylcellulose K4M as the polymers and sodium bicarbonate as a gas generating agent. The tablets were prepared by wet granulation method. A 32 full factorial design was used for optimization of drug release profile. The amount of psyllium husk (X1) and hydroxypropylmethylcellulose K4M (X2) were selected as independent variables. The times required for 50% (t 50% ) and 70% (t 70% ) drug dissolution were selected as dependent variables. All the designed nine batches of formulations were evaluated for hardness, fria... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4659487 Wed, 30 Mar 2011 23:00:00 +0100 4659487 http://www.medworm.com/index.php?rid=4659486&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F5%2F592%2F78526 HO Kaila, MA Ambasana, RS Thakkar, HT Saravaia, AK ShahIndian Journal of Pharmaceutical Sciences 2010 72(5):592-598A reliable and sensitive isocratic stability indicating RP-HPLC method has been developed and validated for assay of rosuvastatin calcium in tablets and for determination of content uniformity. An isocratic separation of rosuvastatin calcium was achieved on YMC C8, 150Χ4.6 mm i.d., 5 μm particle size columns with a flow rate of 1.5 ml/min and using a photodiode array detector to monitor the eluate at 242 nm. The mobile phase consisted of acetonitrile: water (40:60, v/v) pH 3.5 adjusted with phosphoric acid. The drug was subjected to oxidation, hydrolysis, photolysis and thermal degradation. All degradation products in an overall analytical run time of a... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4659486 Wed, 30 Mar 2011 23:00:00 +0100 4659486 http://www.medworm.com/index.php?rid=4659485&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F5%2F587%2F78525 J Jesslin, R Adepu, S ChuriIndian Journal of Pharmaceutical Sciences 2010 72(5):587-591WHO reports estimate poisoning as one of the most common causes of increased morbidity and mortality rate world-wide. Various agents such as pesticides, drugs have been used for intentional and accidental poisoning in different countries. In the Indian scenario, pesticides are the most commonly used poisoning agents. To assess the prevalence and mortality incidence rate due to various poisoning agents a retrospective and prospective study conducted over a period of nine months in a tertiary care teaching hospital. Retrospective data of poisoning cases was collected from the medical records section and the prospective data of poisoning cases was collected from the emergency and causality departments. A to... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4659485 Wed, 30 Mar 2011 23:00:00 +0100 4659485 http://www.medworm.com/index.php?rid=4659484&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F5%2F582%2F78524 AK Barupal, Vandana Gupta, Suman RamtekeIndian Journal of Pharmaceutical Sciences 2010 72(5):582-586The aim of present study was to prepare and characterized ethosomes of aceclofenac which may deliver the drug to targeted site more efficiently than marketed gel preparation and also overcome the problems related with oral administration of drug. The formulations were prepared with varying the quantity of ethanol 10-50% (v/v), lecithin 1-4% (w/v), propylene glycol 5-20% (v/v) and evaluated for their vesicle size, shape and surface morphology, entrapment efficiency and in vitro drug permeation study. Ethosomes of average size of 1.112 μm with a spherical shape bearing smooth surface were observed by transmission electron microscopy and surface electron microsc... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4659484 Wed, 30 Mar 2011 23:00:00 +0100 4659484 http://www.medworm.com/index.php?rid=4659483&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F5%2F576%2F78523 A Semalty, Mona Semalty, BS Rawat, D Singh, M S.M RawatIndian Journal of Pharmaceutical Sciences 2010 72(5):576-581Pharmacosomes are amphiphilic lipid vesicular systems containing phospholipid complexes with a potential to improve bioavailability of poorly water soluble as well as poorly lipophilic drugs. To improve the water solubility, bioavailability and minimize the gastrointestinal toxicity of aceclofenac, its pharmacosomes were prepared. Aceclofenac was complexed with phosphatidylcholine (80%) in two different ratios (1:1 and 2:1) using conventional solvent evaporation technique. Pharmacosomes thus prepared were subjected to solubility and drug content evaluation, scanning electron microscopy, differential scanning calorimetry, X ray powder diffraction and in vitro dissolution... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4659483 Wed, 30 Mar 2011 23:00:00 +0100 4659483 http://www.medworm.com/index.php?rid=4659482&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F5%2F571%2F78522 A Semalty, Mona Semalty, U NautiyalIndian Journal of Pharmaceutical Sciences 2010 72(5):571-575Enalapril maleate is used in the treatment of hypertension and angina pectoris. It shows low bioavailability due to high hepatic first pass metabolism. Hence the present work was undertaken to formulate mucoadhesive buccal films of enalapril maleate with an objective to improve therapeutic efficacy, patient compliance and the bioavailability. In the present study ten formulations of mucoadhesive drug delivery system of enalapril maleate were prepared as buccal films, by solvent casting technique. Sodium carboxymethylcellulose, hydroxylpropylmethylcellulose, hydroxyethylcellulose and polyvinyl pyrrolidone K-90 were used as mucoadhesive polymers. Prepared films were evaluated for their weight, thic... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4659482 Wed, 30 Mar 2011 23:00:00 +0100 4659482 http://www.medworm.com/index.php?rid=4659481&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F5%2F564%2F78521 AH Atta, TA Elkoly, SM Mouneir, Gehan Kamel, NA Alwabel, Shaimaa ZaherIndian Journal of Pharmaceutical Sciences 2010 72(5):564-570The present work was carried out to investigate the hepatoprotective effect of ginger, chicory and their mixture against carbon tetrachloride intoxication in rats. Carbon tetrachloride treatment significantly elevated the alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma glutamyltransferase activities and the serum triglycerides and cholesterol concentration as compared to control group. It also increased RBCs counts and Hb concentration, total or differential leucocytes counts. However it decreased platelet counts, platelet distribution width, mean platelet volume, platelet larger cell ratio. Methanol extract of ginger (250 an... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4659481 Wed, 30 Mar 2011 23:00:00 +0100 4659481 http://www.medworm.com/index.php?rid=4659480&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F5%2F557%2F78520 R Adepu, A ShariffIndian Journal of Pharmaceutical Sciences 2010 72(5):557-563In India, structured continuous professional development modules are not available to update the knowledge and skills of the practicing community pharmacists. A prospective study was designed to develop, validate and implement continuous professional development modules and to assess the impact of training programme on knowledge and skills of community pharmacists. Modules were developed by referring to standard texts and data bases and were validated for the content. The impact of training programme on pharmacists' knowledge and skills was assessed using suitably designed pre and post training knowledge attitude and practice questionnaires, pre and post training questionnaires for individual continuous pr... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4659480 Wed, 30 Mar 2011 23:00:00 +0100 4659480 http://www.medworm.com/index.php?rid=4659479&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F5%2F546%2F78519 Kashmira J Gohil, Jagruti A Patel, Anuradha K GajjarIndian Journal of Pharmaceutical Sciences 2010 72(5):546-556In recent times, focus on plant research has increased all over the world. Centella asiatica is an important medicinal herb that is widely used in the orient and is becoming popular in the West. Triterpenoid, saponins, the primary constituents of Centella asiatica are manly believed to be responsible for its wide therapeutic actions. Apart from wound healing, the herb is recommended for the treatment of various skin conditions such as leprosy, lupus, varicose ulcers, eczema, psoriasis, diarrhoea, fever, amenorrhea, diseases of the female genitourinary tract and also for relieving anxiety and improving cognition. The present review attempts to provide comprehensive information on ... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4659479 Wed, 30 Mar 2011 23:00:00 +0100 4659479 http://www.medworm.com/index.php?rid=4659478&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F5%2F539%2F78518 Isha Patel, R BalkrishnanIndian Journal of Pharmaceutical Sciences 2010 72(5):539-545Medical mistakes that include medication errors have raised concerns about medication safety. Due to high consumption of medicines and self-treatment by all, especially the aging population, the issue of proper medication use and safety is at the forefront of public health concerns globally. Each country has a different approach towards medication event monitoring that is compliant with its own health care system. This paper focuses on the efforts and endeavors of some of the countries around the world to create an efficient error reporting systems to ensure public safety. Our analysis indicates that there are established and effective medication vigilance systems in many developed countries. The different... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4659478 Wed, 30 Mar 2011 23:00:00 +0100 4659478 http://www.medworm.com/index.php?rid=4260141&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F4%2F533%2F73921 S Kumar, R Malhotra, D KumarIndian Journal of Pharmaceutical Sciences 2010 72(4):533-537The present study was carried out to evaluate antidiabetic and in vitro free radicals scavenging effects of flower extract of Euphorbia hirta. The ethanolic and petroleum ether extracts (250 and 500 mg/kg) were orally tested for 21 days in alloxan induced diabetic mice and blood glucose level was measured with glucometer. Administration of extract resulted in significant reduction in serum cholesterol, triglycerides, creatinine, urea, alkaline phosphatase levels but high density lipoprotein levels and total proteins were found to be increased after treatments. Free radicals scavenging effect of ethanolic extract was also evaluated by various antioxidant assays, including 1, 1-diphenyl-2-picryl hydrazyl ... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4260141 Tue, 14 Dec 2010 00:00:00 +0100 4260141 http://www.medworm.com/index.php?rid=4260140&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F4%2F531%2F73923 MK Choudhury, B ZewdieIndian Journal of Pharmaceutical Sciences 2010 72(4):531-533Triphenyltinbenzoate was synthesized using triphenyltinchloride and silver benzoate prepared from sodium benzoate. The structure of the synthetic compound was elucidated by spectral and C, H analysis. The antibacterial activities of the organotin compound were determined against four bacteria namely Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 25923), Streptococcus pyogenes (clinical isolate) and Pseudomonas aeruginosa (ATCC 27853) in vitro experiment. All the bacteria were inhibited at a concentration of 200 μg/ml and 20 μg/ml in dimethylsulphoxide solution and the minimum inhibitory concentration was found to be same, 7.5 μg/ml for Escherichia coli, Staphylo... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4260140 Tue, 14 Dec 2010 00:00:00 +0100 4260140 http://www.medworm.com/index.php?rid=4260139&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F4%2F527%2F73926 R Sharma, K MehtaIndian Journal of Pharmaceutical Sciences 2010 72(4):527-530Three UV spectrophotometric methods have been developed, simultaneous equation method, multicomponent analysis (II) and derivative spectroscopy method (III). The absorption maxima of the drugs were found to be 247, 259 and 272 nm, respectively for efavirenz, tenofovir disoproxil fumarate and lamivudine in methanol:water (50:50) solvent system. Efavirenz, tenofovir disoproxil fumarate and lamivudine obeyed Beer's law in the concentration range of 10-60, 5-30 and 5-30 μg/ml, respectively. Results of analysis for all the three methods were analyzed and validated for various parameters according to ICH guidelines. (Source: Indian Journal of Pharmaceutical Sciences) Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4260139 Tue, 14 Dec 2010 00:00:00 +0100 4260139 http://www.medworm.com/index.php?rid=4260138&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F4%2F525%2F73928 G Mathai, JT Moolayil, KB Jose, VS SebastianIndian Journal of Pharmaceutical Sciences 2010 72(4):525-526A spectrophotometric method of assay of mefenamic acid in tablets involving, dissolving the tablet powder in 1,4-dioxane and measuring the absorbance at 353.2 nm. The concentration of mefenamic acid is determined using the previously prepared calibration curve using standard solution of mefenamic acid in dioxane. The method was tested by assay of six different commercial tablets containing mefenamic acid. (Source: Indian Journal of Pharmaceutical Sciences) Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4260138 Tue, 14 Dec 2010 00:00:00 +0100 4260138 http://www.medworm.com/index.php?rid=4260137&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F4%2F522%2F73930 BP Patel, JK Patel, GC Rajput, RS ThakorIndian Journal of Pharmaceutical Sciences 2010 72(4):522-525The purpose of this research was to develop mouth dissolve tablets of cinnarizine by effervescent, superdisintegrant addition and sublimation methods. All the three formulations were evaluated for disintegration time, hardness and friability, among these superdisintegrant addition method showed lowest disintegration time; hence it was selected for further studies. Further nine batches (B1-B9) were prepared by using crospovidone, croscarmellose sodium and L-HPC in different concentrations such as 5, 7.5 and 10%. All the formulations were evaluated for weight variation, hardness, friability, drug content, in vitro disintegration time, wetting time, in vitro dissolution. Formulation with... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4260137 Tue, 14 Dec 2010 00:00:00 +0100 4260137 http://www.medworm.com/index.php?rid=4260136&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F4%2F520%2F73932 S. T. V. Raghavamma, N Rama RaoIndian Journal of Pharmaceutical Sciences 2010 72(4):520-521Antianthelmintic activity of successive extracts (chloroform, acetone, ethanol and aqueous) of Nauclea orientalis leaves were evaluated separately on adult Indian earthworm (Pheretima posthuma) and compared with that of albendazole. It was found that the extracts exhibited, respectively dose-dependent action and inhibition of spontaneous motility (paralysis) and death of earthworms. The results indicated that the chloroform, ethyl acetate and ethanol extracts were more potent. (Source: Indian Journal of Pharmaceutical Sciences) Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4260136 Tue, 14 Dec 2010 00:00:00 +0100 4260136 http://www.medworm.com/index.php?rid=4260135&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F4%2F517%2F73935 GB Kasawar, MN FarooquiIndian Journal of Pharmaceutical Sciences 2010 72(4):517-519A simple, precise, specific, and accurate reverse phase HPLC method has been developed for the determination of pregabalin in capsule dosage form. The chromatography was set on Hypersil BDS, C8, 150×4.6 mm, 5 μm column using photodiode array detector. The mobile phase consisting of phosphate buffer pH 6.9 and acetonitrile in the ratio of 95:05 with flow rate of 1 ml/min. The method was validated according to ICH guidelines with respect to specificity, linearity, accuracy, precision and robustness. Lower limit of quantification is 0.6 mg/l. The pregabalin sample solution was found to be stable at room temperature for about 26 h. (Source: Indian Journal of Pharmaceutical Sciences) Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4260135 Tue, 14 Dec 2010 00:00:00 +0100 4260135 http://www.medworm.com/index.php?rid=4260134&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F4%2F513%2F73937 The objective of this work was to develop and validate simple, rapid and accurate chromatographic methods for simultaneous determination of ofloxacin and ornidazole in solid dosage form. The first method was based on reversed phase high performance liquid chromatography, on Intersil C 18 column (250 mm, 4.6 i.d.), using acetonitrile:methanol: 0.025M phosphate buffer, pH 3.0 (30:10:60 % v/v/v) as the mobile phase, at a flow rate of 1 ml/min at ambient temperature. Quantification was achieved with UV detection at 318 nm over a concentration range of 2-40 μg/ml for ofloxacin and 5-100 μg/ml for ornidazole. The mean retention time of ofloxacin and ornidazole was found to be 4.04 min and 5.83 min, 6.77 min (isomers), respectively. The amount of ofloxacin and ornid... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4260134 Tue, 14 Dec 2010 00:00:00 +0100 4260134 http://www.medworm.com/index.php?rid=4260133&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F4%2F510%2F73939 SC Jain, B Pancholi, R Singh, R JainIndian Journal of Pharmaceutical Sciences 2010 72(4):510-513Sequential extracts of some medicinally important arid zone plants of Rajasthan, viz. Lepidagathis trinervis Nees., Polycarpea corymbosa Lam. and Sericostoma pauciflorum Stocks. ex Wight. were tested against six bacterial (Gram +ve and Gram -ve) and five fungal strains using agar well diffusion method. Ethyl acetate extract of L. trinervis showed maximum activity against Bacillus subtilis, Enterobactor aerogenes, Pseudomonas aeruginosa, Aspergillus flavus and Trichophyton rubrum (inhibition zone 16.00±0.81, 13.33±0.66, 14.33±1.85, 14.30±0.34 and 23.00±0.00 mm) at varied minimum inhibitory concentrations of 82, 20, 41, 41 and 20 &... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4260133 Tue, 14 Dec 2010 00:00:00 +0100 4260133 http://www.medworm.com/index.php?rid=4260132&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F4%2F508%2F73940 Laxmi Goswami, S Mukhopadhyay, S DurgapalIndian Journal of Pharmaceutical Sciences 2010 72(4):508-510This work deals with the simultaneous estimation of metformin hydrochloride and pioglitazone hydrochloride in a bilayered tablet dosage form, without prior separation by two techniques. The methods employed are derivative spectrophotometery and Q analysis. The absorption maxima at 231 nm and 269 nm were used for the estimation of metformin and pioglitazone, respectively. Both the drugs and their mixture obey Beer-Lamberts law at selected wavelength at given concentration range. The result of analysis has been validated statistically and recovery studies confirmed the accuracy of the proposed method. The proposed procedures are simple, rapid, require no separation steps and can be used for t... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4260132 Tue, 14 Dec 2010 00:00:00 +0100 4260132 http://www.medworm.com/index.php?rid=4260131&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F4%2F504%2F73936 P Ghosh, A Mandal, P Chakraborty, MG Rasul, Madhumita Chakraborty, A SahaIndian Journal of Pharmaceutical Sciences 2010 72(4):504-507In continuation of our studies on the phytochemical investigation of medicinal plants available in the foothills of Darjeeling and Teri, we report herein the isolation of two triterpenoids betulinic acid and lupeol from the leaf extract of Psidium guajava and their potential antimicrobial and phytotoxic activities. All the structures of the isolated compounds were confirmed by spectral (IR, NMR) analysis and by comparison with the literature reports. (Source: Indian Journal of Pharmaceutical Sciences) Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4260131 Tue, 14 Dec 2010 00:00:00 +0100 4260131 http://www.medworm.com/index.php?rid=4260130&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F4%2F500%2F73934 MB Deshmukh, S Patil, SS Patil, SD JadhavIndian Journal of Pharmaceutical Sciences 2010 72(4):500-5042-thio-3-aryl quinazolin-4(3H)one (1) was synthesized by reacting anthranilic acid with thiocarbamate salts of substituted aniline and carbon disulphide, which on reflux with excess of hydrazine hydrate to form 2-hydrazino quinazolin-4(3H)one derivatives (2). The reaction of (2) with variously substituted aryl aldehydes gave the corresponding hydrazones (3). Further, the cyclization of compound (3) in acetic anhydride gave tricyclic pyrazoloquinazolinones (4). All newly synthesized compounds have been tested for their antibacterial activity against gram +ve bacteria B. substilis, S. aureus and gram -ve bacteria E. coli, P. vulgaris. The species used for antifungal activity are Asperg... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4260130 Tue, 14 Dec 2010 00:00:00 +0100 4260130 http://www.medworm.com/index.php?rid=4260129&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F4%2F497%2F73929 Kavitha Sagar, GM VidyasagarIndian Journal of Pharmaceutical Sciences 2010 72(4):497-500The compound, α-(2-hydroxy-2-methylpropyl)-w-(2-hydroxy-3-methylbut-2-en-1-yl)polymethylene, isolated from ethyl acetate leaf extract of Caesalpinia bonducella (L.) Flem. was evaluated for antimicrobial activity against clinical isolates, Proteus vulgaris, Pseudomonas aeruginosa, Klebsiella sp., Staphylococcus citrus, Staphylococcus aureus, Escherichia coli, Candida albicans and Rhodotorula sp. using agar diffusion method. The compound exerted inhibitory zone at all concentrations and revealed the concentration-dependent activity against all tested bacterial and yeast strains comparable to standards streptomycin sulphate and gentamycin for bacteria and fluconazole and griseofulvin for Candid... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4260129 Tue, 14 Dec 2010 00:00:00 +0100 4260129 http://www.medworm.com/index.php?rid=4260128&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F4%2F494%2F73925 PK Saini, CL Jain, RM Singh, SC Mathur, GN SinghIndian Journal of Pharmaceutical Sciences 2010 72(4):494-497A simple, very fast, precise and accurate reverse phase ultra performance liquid chromatographic method was developed for the determination and validation of topotecan hydrochloride in bulk and injection dosage form. A Waters BEH C18, 50Χ2.1 mm, 1.7 μm particle size column in gradient mode was used with mobile phase comprising of 0.1% v/v orthophosphoric acid in water and acetonitrile. The analytical column was thermostated at 50° and flow rate was set at 0.4 ml per min, with photo diode array detection at 260 nm. The retention time of topotecan was found 1.38 min. The method was validated in terms of linearity, accuracy, precision and speci... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4260128 Tue, 14 Dec 2010 00:00:00 +0100 4260128 http://www.medworm.com/index.php?rid=4260127&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F4%2F491%2F73922 A Choudhury, S Das, S Bahadur, S Saha, A RoyIndian Journal of Pharmaceutical Sciences 2010 72(4):491-494Omeprazole pellets containing mucoadhesive tablets were developed by direct punch method. Three mucoadhesive polymers namely hydroxypropylemethylcellulose K4M, sodium carboxy methylcellulose, carbopol-934P and ethyl cellulose were used for preparation of tablets which intended for prolong action may be due to the attachment with intestinal mucosa for relief from active duodenal ulcer. Mucoadhesive tablets were coated with respective polymer and coated with Eudragit L100 to fabricate enteric coated tablets. The prepared tablets were evaluated for different physical parameters and dissolution study were performed in three dissolution mediums like 0.1N hydrochloric acid for 2h, pH 6.5 and p... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4260127 Tue, 14 Dec 2010 00:00:00 +0100 4260127 http://www.medworm.com/index.php?rid=4260126&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F4%2F486%2F73905 In this study it was observed that the ligand was successfully docked on a major portion of antigenic site II of glycoprotein by mimicking the virus neutralizing antibodies. This knowledge may be important for the development of novel therapies for the treatment of rabies and other viral diseases in the future. (Source: Indian Journal of Pharmaceutical Sciences) Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4260126 Tue, 14 Dec 2010 00:00:00 +0100 4260126 http://www.medworm.com/index.php?rid=4260125&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F4%2F480%2F73908 A Purnima, BC Koti, A. H. M. Thippeswamy, MS Jaji, A. H. M. Vishwantha Swamy, YV Kurhe, A Jaffar SadiqIndian Journal of Pharmaceutical Sciences 2010 72(4):480-485In the present study, 70% ethanol extract of Mimusops elengi Linn. bark was assessed for antiinflammatory, analgesic and antipyretic activities in animals. The antiinflammatory activity of ethanol extract of Mimusops elengi (200 mg/kg, p.o) was evaluated using carrageenan-induced paw edema and cotton pellet-induced granuloma models. Analgesic effect was evaluated using acetic acid-induced writhing and Eddy's hot plate models and antipyretic activity was assessed by Brewer's yeast-induced pyrexia in rats. The ethanol extract of Mimusops elengi (200 mg/kg, p.o) significantly inhibited the carrageenan-induced paw... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4260125 Tue, 14 Dec 2010 00:00:00 +0100 4260125 http://www.medworm.com/index.php?rid=4260124&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F4%2F471%2F73912 NR Kotagale, CJ Patel, AP Parkhe, HM Khandelwal, JB Taksande, MJ UmekarIndian Journal of Pharmaceutical Sciences 2010 72(4):471-479The present work aims at developing mucoahesive tablets of ondansetron hydrochloride using bioadhesive polymers like carbopol-934, sodium alginate and gelatin. Tablets prepared by direct compression using different polymer with varying ratio were evaluated for hardness, friability, uniformity of weight, disintegration time, microenvironmental pH, bioadhesion and in vitro release. Hardness, friability disintegration time and drug release were found within pharmacopoeial limit. Microenvironmental pH decreased whereas bioadhesive strength, water uptake, and in vitro release increased with increase in carbopol-934. Increasing sodium alginate and gelatin increased t... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4260124 Tue, 14 Dec 2010 00:00:00 +0100 4260124 http://www.medworm.com/index.php?rid=4260123&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F4%2F465%2F73914 S Kollipara, G Bende, RN SahaIndian Journal of Pharmaceutical Sciences 2010 72(4):465-470A simple and fast reversed phase liquid chromatographic method was developed for estimation of paclitaxel in commercially available parenteral formulation and nanoparticles. Separations were carried out using mobile phase consisting of acetonitrile and 20 mM potassium dihydrogen phosphate (45:55, v/v) on Lichrocart® C 18 analytical column at a flow rate of 1 ml/min and detection wavelength of 230 nm. The developed method exhibited linearity over an analytical range of 50-2000 ng/ml with regression equation, mean peak area= 137.58 concentration (ng/ml)+1765.94, (R 2 =0.9999). The method demonstrated selectivity with no interfering peaks eluting near the vicinity of drug peak. The meth... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4260123 Tue, 14 Dec 2010 00:00:00 +0100 4260123 http://www.medworm.com/index.php?rid=4260122&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F4%2F458%2F73917 S Kumar, DP SrivastavaIndian Journal of Pharmaceutical Sciences 2010 72(4):458-464An efficient electrochemical method for the preparation of 2-amino-5-substituted-1,3,4-oxadiazoles (4a-k) at platinum anode through the electrooxidation of semicarbazone (3a-k) at controlled potential electrolysis has been reported in the present study. The electrolysis was carried out in the acetic acid solvent and lithium perchlorate was used as supporting electrolyte. The products were characterized by IR, 1 H-NMR, 13 C-NMR, mass spectra and elemental analysis. The synthesized compounds were screened for their in vitro growth inhibiting activity against different strains of bacteria viz., Klebsilla penumoniae, Escherichia coli, Bassilus subtilis and Streptococcus aureus and antifungal activity against Aspe... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4260122 Tue, 14 Dec 2010 00:00:00 +0100 4260122 http://www.medworm.com/index.php?rid=4260121&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F4%2F449%2F73919 T Femlin Blessia, VS Rapheal, D. J. S. SharmilaIndian Journal of Pharmaceutical Sciences 2010 72(4):449-457Synthetic sialic acid analogues with multiple modifications at different positions(C-1/C-2/C-4/C-8/C-9) are investigated by molecular mechanics and molecular dynamics to determine their conformational preferences and structural stability to interact with their natural receptors. Sialic acids with multiple modifications are soaked in a periodic box of water as solvent. Molecular mechanics and a 2 nanosecond molecular dynamics are done using amber force fields with 30 picosecond equilibrium. Direct and water mediated hydrogen bonds existing in the sialic acid analogues, aiding for their structural stabilization are identified in this study. The accessible conformations of side chain lin... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4260121 Tue, 14 Dec 2010 00:00:00 +0100 4260121 http://www.medworm.com/index.php?rid=4260120&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F4%2F442%2F73916 JJ Parmar, DJ Singh, Darshana D Hegde, AA Lohade, PS Soni, A Samad, Mala D MenonIndian Journal of Pharmaceutical Sciences 2010 72(4):442-448Budesonide is a corticosteroid used by inhalation in the prophylactic management of asthma. However, frequent dosing and adverse effects (local and systemic) remain a major concern in the use of budesonide. Liposomal systems for sustained pulmonary drug delivery have been particularly attractive because of their compatibility with lung surfactant components. In the present investigation, pulmonary liposomal delivery system of budesonide was prepared by film hydration method and evaluated for sustained release. Various parameters were optimized with respect to entrapment efficiency as well as particle size of budesonide liposomes. For better shelf life ... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4260120 Tue, 14 Dec 2010 00:00:00 +0100 4260120 http://www.medworm.com/index.php?rid=4260119&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F4%2F437%2F73913 P Chattopadhyay, P Chaudhury, AK WahiIndian Journal of Pharmaceutical Sciences 2010 72(4):437-441Ischemic and reperfusion injury leads to necrosis and apoptosis. Mitochondrial enzymes and antiapoptotic gene plays an important role in necrosis and apoptosis. The aim of this study was to investigate the role of Bcl-2 expression in alternations in mitochondrial energy regulation during hepatic ischemia and reperfusion and role in necrosis and apoptosis. Total 12 Wistar rats were divided into sham-operated control group (I) and ischemia and reperfusion group (II). Mitochondrial tri carboxylic acid cycles marker enzymes, respiratory marker enzymes, apoptotic cells, necrotic cells and Bcl-2 expression was measured. Number of necrotic and apoptotic cells were increased in ischemic and reperfusion... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4260119 Tue, 14 Dec 2010 00:00:00 +0100 4260119 http://www.medworm.com/index.php?rid=4260118&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F4%2F431%2F73911 SB Shirsand, Sarasija Suresh, LS Jodhana, PV SwamyIndian Journal of Pharmaceutical Sciences 2010 72(4):431-436Fast disintegrating tablets of lorazepam were prepared by effervescent method with a view to enhance patient compliance. A 3΂ full factorial design was applied to investigate the combined effect of two formulation variables: amount of crospovidone and mixture of sodium bicarbonate, citric acid and tartaric acid (effervescent material) on in vitro dispersion time. Crospovidone (2-8% w/w) was used as superdisintegrant and mixture of sodium bicarbonate, citric acid and tartaric acid (6-18% w/w) was used as effervescent material, along with directly compressible mannitol to enhance mouth feel. The tablets were evaluated for hardness, friability, thickness, dru... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4260118 Tue, 14 Dec 2010 00:00:00 +0100 4260118 http://www.medworm.com/index.php?rid=4260117&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F4%2F426%2F73909 G Swami, Khushboo Gupta, KM Kymonil, Shubhini SarafIndian Journal of Pharmaceutical Sciences 2010 72(4):426-430The present research paper introduces soyabean nuggets powder, as a novel excipient with nutraceutical value for tablets containing cholesterol lowering drug, simvastatin. Experiments were carried out to evaluate the suitability of soyabean nuggets powder as a diluent by incorporating in tablet formulation of simvastatin. The formulation was compared with the marketed product to determine its relative efficacy. Soyabean nuggets powder was found to be a promising diluent for tablets for both pharmaceutical and nutraceutical purposes. Simavastatin soya tablet showed acceptable pharmacotechnical properties and assay requirement. (Source: Indian Journal of Pharmaceutical Sciences) Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4260117 Tue, 14 Dec 2010 00:00:00 +0100 4260117 http://www.medworm.com/index.php?rid=4260116&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F4%2F421%2F73906 GA ShabirIndian Journal of Pharmaceutical Sciences 2010 72(4):421-425A novel reversed-phase HPLC method has been developed and validated for the simultaneous determination of 2-phenoxyethanol, methylparaben, ethylparaben and propylparaben preservatives. The method uses a Lichrosorb C8 (150Χ4.6 mm, 5 μm) column and isocratic elution. The mobile phase consisted of a mixture of acetonitrile, tetrahydrofuran and water (21:13:66, v/v/v), pumped at a flow rate of 1 ml/min. The UV detection was set at 258 nm. The method was validated with respect to accuracy, precision (repeatability and intermediate precision), specificity, linearity and range. All the parameters examined met the current recommendations for bioanalytical method validation. The developed method was success... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4260116 Tue, 14 Dec 2010 00:00:00 +0100 4260116 http://www.medworm.com/index.php?rid=4260115&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F4%2F414%2F73904 AN Zaid, R Cortesi, J Kort, W SweilehIndian Journal of Pharmaceutical Sciences 2010 72(4):414-420The aim of the study was to evaluate if two capsules (Amoxil® capsules, 500 mg/capsule) and one tablet (Amoxicare® tablets, 1000 mg/tablet) of amoxicillin have similar bioequivalence parameters. For this purpose a randomized, two-way, crossover, bioequivalence study was performed in 24 healthy, male volunteers, divided into two groups of 12 subjects each. One group was treated with the reference standard (Amoxil® ) and the other one with the generic tablet Amoxicare® , with a crossover after a wash-out period of 7 days. Blood samples were collected at fixed time intervals and amoxicillin was determined by a validated HPLC method. The pharmacokinet... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4260115 Tue, 14 Dec 2010 00:00:00 +0100 4260115 http://www.medworm.com/index.php?rid=4260114&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Ftext.asp%3F2010%2F72%2F4%2F409%2F73902 SZ Rahman, V Gupta, Anupama Sukhlecha, Y KhunteIndian Journal of Pharmaceutical Sciences 2010 72(4):409-413Lifestyle has changed from being an indicator of the overall well being of an individual to a cause of disease and now "lifestyle" has itself become an object of medical attention. Alcohol has been used enormously as one of the oldest 'lifestyle' drugs, and currently sildenafil citrate (Viagra), the drug of choice for erectile dysfunction, exemplifies a turning point in the era of modern lifestyle drugs. This drug has transformed the lifestyles of millions and greatly increased the revenue of many pharmaceutical companies. With the Indian economy growing rapidly at an annual rate of 8-9%, a new era of drug discovery and development coupled with an enormo... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=4260114 Tue, 14 Dec 2010 00:00:00 +0100 4260114 http://www.medworm.com/index.php?rid=3989423&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Farticle.asp%3Fissn%3D0250-474X%3Byear%3D2010%3Bvolume%3D72%3Bissue%3D3%3Bspage%3D404%3Bepage%3D408%3Baulast%3DRao PH Rao, SG KabraIndian Journal of Pharmaceutical Sciences 2010 72(3):404-408A prescription audit was carried out among the outpatient attendees of 31 secondary level hospitals under Maharashtra Health Systems Development Project. Use of drugs and cost of treatment of diarrhoea were studied using the prescriptions for diarrhoea collected for the prescription audit. Average number of drugs prescribed per prescription for treatment of diarrhoea was 3.7. It was higher than average number of drugs per prescription in the Maharashtra Health Systems Development Project hospitals in general. About three fourths of the prescriptions contained oral rehydration salts. Furazolidone and metronidazole were prescribed in about half of the prescriptions. Cotrimoxazole was prescribed in about one fourth of... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=3989423 Thu, 23 Sep 2010 06:10:10 +0100 3989423 http://www.medworm.com/index.php?rid=3989422&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Farticle.asp%3Fissn%3D0250-474X%3Byear%3D2010%3Bvolume%3D72%3Bissue%3D3%3Bspage%3D401%3Bepage%3D404%3Baulast%3DBarhate VD Barhate, Priya DeosthaleeIndian Journal of Pharmaceutical Sciences 2010 72(3):401-404A forced degradation study on roflumilast drug substance was conducted under the conditions of hydrolysis, oxidation, thermal and photolysis. The method was developed and optimized by analyzing forcefully degraded samples. The best separation was achieved on a Zorbax SB C18 1.8 ΅m column with 0.005 M ammonium formate buffer pH 3.5 and acetonitrile as mobile phase in a 13 min run time. The proposed method was able to resolve all the possible degradation products formed during stress study. The drug was stable to neutral, thermal and photolytic conditions but unstable to acidic, alkaline and oxidative conditions at 80Ί for 24 h. The degradation products resulting from stress study ... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=3989422 Thu, 23 Sep 2010 06:10:10 +0100 3989422 http://www.medworm.com/index.php?rid=3989421&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Farticle.asp%3Fissn%3D0250-474X%3Byear%3D2010%3Bvolume%3D72%3Bissue%3D3%3Bspage%3D397%3Bepage%3D401%3Baulast%3DPawar Pallavi L Pawar, Bela M NabarIndian Journal of Pharmaceutical Sciences 2010 72(3):397-401Extracts of Aloe vera whole plant, Eucalyptus globulus leaves, Ficus infectoria bark, Ficus religiosa bark and Piper betel leaves were studied for antibacterial activity on resistant and sensitive strains, isolated from skin and soft tissue infections. A combination of hot alcoholic extracts of Ficus infectoria, Ficus religiosa and Piper betel were found to be more effective against all the isolates. The combined extract was formulated in different ointment bases such as polyethylene glycol, gelatin, sodium alginate, carbopol, cream base and honey. These were then evaluated to find a suitable base for preparation of an ointment. In vitro study of the release of antimicrobials and kill-time studies of t... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=3989421 Thu, 23 Sep 2010 06:10:10 +0100 3989421 http://www.medworm.com/index.php?rid=3989420&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Farticle.asp%3Fissn%3D0250-474X%3Byear%3D2010%3Bvolume%3D72%3Bissue%3D3%3Bspage%3D392%3Bepage%3D396%3Baulast%3DPatel Parvati B Patel, TK Patel, P Shah, Seema N Baxi, HO Sharma, CB TripathiIndian Journal of Pharmaceutical Sciences 2010 72(3):392-396The aim of the present study was to explore the hepatoprotective activity of the ethanol extract of leaves of Gymnosporia montana (Roth) Bemth. (Family: Celastraceous) against paracetamol-induced hepatotoxicity. Hepatotoxicity in Wistar rats was induced by a single intraperitoneal dose of 500 mg/kg of paracetamol and studied by comparing parameters such as serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, alkaline phosphatase and histopathological examination of liver. Pre and post-treatment with ethanol extract of Gymnosporia montana (Roth) Bemth. at doses of 50 and 100 mg/kg was studied by comparing the above mentioned paramete... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=3989420 Thu, 23 Sep 2010 06:10:10 +0100 3989420 http://www.medworm.com/index.php?rid=3989419&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Farticle.asp%3Fissn%3D0250-474X%3Byear%3D2010%3Bvolume%3D72%3Bissue%3D3%3Bspage%3D388%3Bepage%3D392%3Baulast%3DAkter A Akter, FA Neela, M. S. I. Khan, MS Islam, MF AlamIndian Journal of Pharmaceutical Sciences 2010 72(3):388-392Organic extracts (ethanol, petroleum ether and chloroform) of two medicinal plants Lawsonia inermis L. and Mimosa pudica L. were proven for antibacterial properties against 15 Gram-positive and Gram-negative human pathogenic bacteria. Among the three types of extracts tested, ethanol extract was found to possess maximum antibacterial activity. The diameter of the zone of inhibition of bacterial growth showed that Gram-negative bacteria are more sensitive than Gram-positive bacteria to plant extracts. Between the two plants species studied, Lawsonia inermis extract showed more antibacterial activity compared to Mimosa pudica extract. (Source: Indian Journal of Pharmaceutical Scienc... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=3989419 Thu, 23 Sep 2010 06:10:10 +0100 3989419 http://www.medworm.com/index.php?rid=3989418&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Farticle.asp%3Fissn%3D0250-474X%3Byear%3D2010%3Bvolume%3D72%3Bissue%3D3%3Bspage%3D384%3Bepage%3D387%3Baulast%3DNagori BP Nagori, Renu SolankiIndian Journal of Pharmaceutical Sciences 2010 72(3):384-387A new reverse phase high performance liquid chromatography method for the simultaneous estimation of frusemide and amiloride hydrochloride in tablet formulation is developed. The determination was carried out on a HIQ SIL, C18 (250Χ4.6 mm, 5 μm) column using a mobile phase of 50 mM phosphate buffer solution:acetonitrile (50:50 v/v, pH 3.0). The flow rate was 1.0 ml/min with detection at 283 nm. The retention time for frusemide was 3.038 min and for amiloride hydrochloride 10.002 min. Frusemide and amiloride hydrochloride showed a linear response in the concentration range of 20-200 μg/ml and 10-100 μg/ml, respectively. The results of analysis have been validate... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=3989418 Thu, 23 Sep 2010 06:10:10 +0100 3989418 http://www.medworm.com/index.php?rid=3989417&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Farticle.asp%3Fissn%3D0250-474X%3Byear%3D2010%3Bvolume%3D72%3Bissue%3D3%3Bspage%3D381%3Bepage%3D384%3Baulast%3DKaila HO Kaila, MA Ambasana, RS Thakkar, HT Saravaia, AK ShahIndian Journal of Pharmaceutical Sciences 2010 72(3):381-384A simple, precise and accurate HPLC method has been developed and validated for assay of lercanidipine hydrochloride in tablets and for determination of content uniformity. An isocratic separation was achieved using a Chromasil YMC Pack C 8 , 150 Χ 4.6 mm i.d., 5μm particle size columns with a flow rate of 1 ml/min and using a UV detector to monitor the elute at 240 nm. The mobile phase consisted of 0.02 M ammonium dihydrogen phosphate buffer:methanol (35:65, v/v) with pH 3.5 adjusted with phosphoric acid. The method was validated for specificity, linearity, pre-cision, accuracy, robustness and solution stability. The specificity of the method was deter... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=3989417 Thu, 23 Sep 2010 06:10:10 +0100 3989417 http://www.medworm.com/index.php?rid=3989416&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Farticle.asp%3Fissn%3D0250-474X%3Byear%3D2010%3Bvolume%3D72%3Bissue%3D3%3Bspage%3D378%3Bepage%3D380%3Baulast%3DMistry B Mistry, Dipti Medhane, Krishnapriya Mohanraj, Sanjeevani A GhoneIndian Journal of Pharmaceutical Sciences 2010 72(3):378-380Rapid and efficient methods for the synthesis of an important intermediate of benazepril ethyl 3-phthalimido-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one-1-acetate under the influence of microwave irradiation are described. A comparative study of conventional and microwave assisted method is briefly discussed. (Source: Indian Journal of Pharmaceutical Sciences) Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=3989416 Thu, 23 Sep 2010 06:10:10 +0100 3989416 http://www.medworm.com/index.php?rid=3989415&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Farticle.asp%3Fissn%3D0250-474X%3Byear%3D2010%3Bvolume%3D72%3Bissue%3D3%3Bspage%3D375%3Bepage%3D378%3Baulast%3DPaneersalvam P Paneersalvam, T Raj, M.P.S. Ishar, B Singh, V Sharma, BA RatherIndian Journal of Pharmaceutical Sciences 2010 72(3):375-378Schiff bases (9a-l) of 3-amino-6,8-dibromo-2-phenyl-quinazolin-4-(3H)-ones (8) with various substituted aldehydes were obtained by refluxing 1:1 molar equivalents of the reactants in dry ethanol for 6 h. The aminoquinazoline (8) was inturn obtained from 3,5-dibromoantharlinic acid via intermediate (7). All the synthesized compounds (9a-l) were evaluated for their anticonvulsant activity on albino mice by maximal electroshock method using phenytoin as a standard. The compound (9l) bearing a cinnamyl function displays a very high activity (82.74 %) at dose level of 100 mg/kg b.w. (Source: Indian Journal of Pharmaceutical Sciences) Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=3989415 Thu, 23 Sep 2010 06:10:10 +0100 3989415 http://www.medworm.com/index.php?rid=3989414&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Farticle.asp%3Fissn%3D0250-474X%3Byear%3D2010%3Bvolume%3D72%3Bissue%3D3%3Bspage%3D371%3Bepage%3D375%3Baulast%3DPathak Shalini Pathak, MM Wanjari, SK Jain, M TripathiIndian Journal of Pharmaceutical Sciences 2010 72(3):371-375In the present study, the effect of essential oil of the root of Angelica archangelica Linn. was evaluated against electrically and chemically induced seizures. The seizures were induced in mice by maximal electroshock and pentylenetetrazol. The effect of essential oil of the root of Angelica archangelica on seizures was compared with standard anticonvulsant agents, phenytoin and diazepam. The essential oil of the root of Angelica archangelica suppressed duration of tonic convulsions and showed recovery in maximal electroshock induced seizures while it delayed time of onset of clonic convulsions and showed mortality protection in pentylenetetrazol induced seizures. The essential oil o... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=3989414 Thu, 23 Sep 2010 06:10:10 +0100 3989414 http://www.medworm.com/index.php?rid=3989413&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Farticle.asp%3Fissn%3D0250-474X%3Byear%3D2010%3Bvolume%3D72%3Bissue%3D3%3Bspage%3D367%3Bepage%3D371%3Baulast%3DThippeswamy A. H. M. Thippeswamy, M Sajjan, MB Palkar, BC Koti, A.H.M. ViswanathaswamyIndian Journal of Pharmaceutical Sciences 2010 72(3):367-371The present study was designed to compare ulcer protective effect of proton pump inhibitors viz. omeprazole, rabeprazole and lansoprazole against dexamethasone plus pylorus ligation induced ulcer model. Dexamethasone (5 mg/kg) was used as an ulcerogen. Dexamethasone suspended in 1% CMC in water was given orally to all the rats 15 min after the pylorus ligation. Omeprazole (20 mg/kg), rabeprazole (20 mg/kg), and lansoprazole (20 mg/kg) were administered by oral route 30 min prior to ligation was used for ulcer protective studies, gastric secretion and mucosal studies. Effects of proton pump inhibitors were determined by the evaluation of various bioche... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=3989413 Thu, 23 Sep 2010 06:10:10 +0100 3989413 http://www.medworm.com/index.php?rid=3989412&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Farticle.asp%3Fissn%3D0250-474X%3Byear%3D2010%3Bvolume%3D72%3Bissue%3D3%3Bspage%3D363%3Bepage%3D367%3Baulast%3DSingh This study has highlighted the importance of distal alkyl chain which influences the anticonvulsant activity. (Source: Indian Journal of Pharmaceutical Sciences) Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=3989412 Thu, 23 Sep 2010 06:10:10 +0100 3989412 http://www.medworm.com/index.php?rid=3989411&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Farticle.asp%3Fissn%3D0250-474X%3Byear%3D2010%3Bvolume%3D72%3Bissue%3D3%3Bspage%3D360%3Bepage%3D362%3Baulast%3DVijayakumar E. K. S. Vijayakumar, VG Gore, A Mahajan, M KumarIndian Journal of Pharmaceutical Sciences 2010 72(3):360-362A new process impurity was detected during the HPLC analysis of Tizanidine hydrochloride (I) batches. The impurity (II) was isolated by preparative HPLC and characterized by NMR and Mass spectral analysis as 5-S-ethyl-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine hydrochloride. (Source: Indian Journal of Pharmaceutical Sciences) Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=3989411 Thu, 23 Sep 2010 06:10:10 +0100 3989411 http://www.medworm.com/index.php?rid=3989410&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Farticle.asp%3Fissn%3D0250-474X%3Byear%3D2010%3Bvolume%3D72%3Bissue%3D3%3Bspage%3D357%3Bepage%3D360%3Baulast%3DKumar P Manoj Kumar, TK Ravi, R Chawla, S Bhuvana, G Sonia, S GopalakrishnanIndian Journal of Pharmaceutical Sciences 2010 72(3):357-360A series of new 3-(4-methylcoumarinyl-7-oxymethyl)-6-substitutedphenyl-5,6-dihydro-s-triazolo (3,4-b)(1,3,4)-thiadiazoles 2(a-j) have been synthesized by reacting 5-(4-methyl coumarinyl-7-oxymethyl)-4-amino-3-mercapto(4H)-1,2,4-triazole with various aromatic aldehydes by microwave assisted organic synthesis. The structure of the compounds 2 (a-j) has been confirmed by IR, 1 H NMR and mass spectral data. All the compounds were screened for antimicrobial and antioxidant activity. Among the compounds tested, compounds 2d (4-dimethyl amino phenyl derivative) and 2h (3,4-dimethoxy phenyl derivative) showed better antimicrobial and antioxidant activity than rest of th... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=3989410 Thu, 23 Sep 2010 06:10:10 +0100 3989410 http://www.medworm.com/index.php?rid=3989409&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Farticle.asp%3Fissn%3D0250-474X%3Byear%3D2010%3Bvolume%3D72%3Bissue%3D3%3Bspage%3D353%3Bepage%3D357%3Baulast%3DOkonkwo T. J. N. Okonkwo, O Okorie, JM Okonta, CJ OkonkwoIndian Journal of Pharmaceutical Sciences 2010 72(3):353-357The extracts of Anacardium occidentale have been used in the management of different cardiovascular disorders in Nigeria. These have necessitated the assessment of the toxicity of this plant extract in sub-chronic administration. The inner stem bark of Anacardium occidentale was extracted with 80 % methanol and quantitatively analysed for antinutrients and some heavy metals. The phytochemical compositions and acute toxicity of the extract were determined also. Toxicity profiles of the extract on some liver function parameters were evaluated following a sub-chronic oral administration at doses of 1.44 and 2.87 g/kg. The phytochemical screening of extract revealed the presence ... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=3989409 Thu, 23 Sep 2010 06:10:10 +0100 3989409 http://www.medworm.com/index.php?rid=3989408&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Farticle.asp%3Fissn%3D0250-474X%3Byear%3D2010%3Bvolume%3D72%3Bissue%3D3%3Bspage%3D346%3Bepage%3D352%3Baulast%3DGogu The objective of the present study was to prepare and characterize in vitro and in vivo performance of a sustained release microsphere formulation of 4-chlorocurcumin, a novel curcumin analogue. A spray dried technique with ethylcellulose as the polymer was used in the preparation of these microspheres. Microspheres were characterized for drug content, particle size and shape, in vitro drug release and the drug-polymer interaction. To assess in vivo performance, both pharmacokinetics and hepatoprotective activity were investigated. Results were compared with an equivalent i.v. solution. The microspheres of 4-chlorocurcumin with ethylcellulose were successfully prepared using a spray-dried technique. These microspheres were able to sustain the release of the drug both in vitro as well as in... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=3989408 Thu, 23 Sep 2010 06:10:10 +0100 3989408 http://www.medworm.com/index.php?rid=3989407&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Farticle.asp%3Fissn%3D0250-474X%3Byear%3D2010%3Bvolume%3D72%3Bissue%3D3%3Bspage%3D340%3Bepage%3D345%3Baulast%3DChaudhary A Chaudhary, SK Singla, C TandonIndian Journal of Pharmaceutical Sciences 2010 72(3):340-345Urinary stones are one of the oldest and the most common afflictions in humans. This disease has tormented humans since the earliest records of civilization. Ten percent of men and 3 % of women have a stone during their adult lives. Calcium containing stones are the most common comprising about 75 % of all urinary calculi, which may be in the form of pure calcium oxalate (50 %) or calcium phosphate (5 %) or a mixture of both (45 %). A number of plants have been mentioned in the Indian ayurvedic system, which plays a vital role in the inhibition of kidney stones. In the present study, the inhibitory potency of crude extracts or fractions of successive solvent extrac... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=3989407 Thu, 23 Sep 2010 06:10:10 +0100 3989407 http://www.medworm.com/index.php?rid=3989406&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Farticle.asp%3Fissn%3D0250-474X%3Byear%3D2010%3Bvolume%3D72%3Bissue%3D3%3Bspage%3D334%3Bepage%3D339%3Baulast%3DEzike AC Ezike, PA Akah, CO Okoli, S Udegbunam, N Okwume, C Okeke, O IloaniIndian Journal of Pharmaceutical Sciences 2010 72(3):334-339The effects of the methanol extract of the stem bark of Prosopis africana (Guill., Perrott. and Rich.) Taubert (Fabaceae) on bleeding/clotting and coagulation time, excision and dead space wounds were studied in rats. Also, the extract was subjected to antibacterial, and acute toxicity and lethality (LD 50 ) tests. The extract significantly (P<0.05) reduced bleeding/clotting and coagulation time in rats. It also reduced epithelialization period of excision wounds in rats and inhibited the growth of laboratory strains of Staphylococcus aureus, Bacillus subtilis, Salmonella typhi, Pseudomonas aeruginosa and Klebsiella pneumoniae to varying extents. Acute ... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=3989406 Thu, 23 Sep 2010 06:10:10 +0100 3989406 http://www.medworm.com/index.php?rid=3989405&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Farticle.asp%3Fissn%3D0250-474X%3Byear%3D2010%3Bvolume%3D72%3Bissue%3D3%3Bspage%3D324%3Bepage%3D333%3Baulast%3DAdane L Adane, PV BharatamIndian Journal of Pharmaceutical Sciences 2010 72(3):324-333A molecular docking study was carried out on 28 compounds belonging to 2,4-diaminoquinazoline and 2,4-diaminopteridine analogs using Glide, FlexX and GOLD programs and the X-ray crystallographic structures of the quadruple mutant (1J3K:pdb) and wild type (1J3I:pdb) Plasmodium falciparum dihydrofolate reductase enzyme. The experimental conformation the bound ligand WR99210 was precisely reproduced by the docking procedures as demonstrated by low (<2.00 Ε) root-mean-square deviations. The results indicated that most of the compounds dock into the active sites of both the wild type and quadruple mutant P. falciparum dihydrofolate reductase enzymes. Visual inspection of the binding modes also ... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=3989405 Thu, 23 Sep 2010 06:10:10 +0100 3989405 http://www.medworm.com/index.php?rid=3989404&cid=s_33846_13_f&fid=33846&url=http%3A%2F%2Fwww.ijpsonline.com%2Farticle.asp%3Fissn%3D0250-474X%3Byear%3D2010%3Bvolume%3D72%3Bissue%3D3%3Bspage%3D318%3Bepage%3D323%3Baulast%3DSapkal Nidhi P Sapkal, Vaishali A Kilor, Bharti D Shewale, KP Bhusari, AS DaudIndian Journal of Pharmaceutical Sciences 2010 72(3):318-323Fexofenadine is a selective histamine H 1 receptor antagonist, used for relief of the symptoms of allergy. However its aqueous solubility is very poor. Solid inclusion complexes of fexofenadine and β-cyclodextrin were prepared at the molar ratios of 1:1 and 1:2 by kneading, and coprecipitation methods to improve its solubility. Characterization of the complexes was performed using infrared spectroscopy, X-ray diffractometry, and in vitro dissolution studies. Fexofenadine was found to exhibit interaction with β-cyclodextrin both in solid and liquid state. Phase solubility studies indicated that fexofenadine forms a stable complex with &#x... Indian Journal of Pharmaceutical Sciences journals http://www.medworm.com/rss/comments.php?id=3989404 Thu, 23 Sep 2010 06:10:10 +0100 3989404