MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Inflammation' source. Sat, 20 Mar 2010 16:02:50 +0100 http://www.medworm.com/index.php?rid=3373612&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9j5v8049423tk8l7%2F Abstract  Plasma levels of the inflammatory biomarker soluble urokinase plasminogen activator (suPAR) have been shown to carry prognostic information in various infectious and inflammatory diseases. The present study aimed to compare the prognostic value of urine suPAR (U-suPAR) to that of plasma suPAR (P-suPAR), thereby exploring the possibility of replacing the blood sample with an easy obtainable urine sample. We enrolled 1,007 adults, older than 15 years of age, with a negative TB diagnosis between April 2004 and December 2006. Levels of U-suPAR and P-suPAR were available in 863 individuals. U-suPAR was measured using a commercial ELISA (suPARnostic®). We found that U-suPAR carried significant prognostic information on mortality for HIV-infected subjects with an a... Inflammation journals http://www.medworm.com/rss/comments.php?id=3373612 Mon, 15 Mar 2010 05:32:55 +0100 3373612 http://www.medworm.com/index.php?rid=3369635&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd80l744585774536%2F In conclusion, prenatal exposure to zymosan resulted in the activation of intrarenal renin-Ang system in adult offspring rats. Content Type Journal ArticleDOI 10.1007/s10753-010-9199-yAuthors Xue-Qin Hao, Third Military Medical University Institute of Materia Medica and Department of Pharmaceutics, College of Pharmacy Chongqing 400038 ChinaHai-Gang Zhang, Third Military Medical University Institute of Materia Medica and Department of Pharmaceutics, College of Pharmacy Chongqing 400038 ChinaShu-Hui Li, Third Military Medical University Institute of Materia Medica and Department of Pharmaceutics, College of Pharmacy Chongqing 400038 ChinaYi Jia, Third Military Medical University Institute of Materia Medica and Department of Pharmaceutics, College of Pharmacy Chongqing 400038 ChinaYa ... Inflammation journals http://www.medworm.com/rss/comments.php?id=3369635 Sun, 14 Mar 2010 11:26:22 +0100 3369635 http://www.medworm.com/index.php?rid=3362040&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F741437t67767777x%2F In this study, we established a mouse model of lipopolysaccharide (LPS)-induced inflammatory lung injury and investigated the effect of valnemulin (100 mg/kg) on acute lung injury (ALI) 8 h after LPS challenge. We prepared bronchoalveolar lavage fluid (BALF) for measuring protein concentrations, cytokine levels, and superoxidase dismutase (SOD) activity, and collected lungs for assaying wet-to-dry weight (W/D) ratios, myeloperoxidase (MPO) activity, cytokine mRNA expression, and histological change. We found that the pre-administration of valnemulin significantly decreases the W/D ratio of lungs, protein concentrations, and the number of total cells, neutrophils, macrophages, and leukomonocytes, and histologic analysis indicates that valnemulin significantly attenuates tiss... Inflammation journals http://www.medworm.com/rss/comments.php?id=3362040 Thu, 11 Mar 2010 02:45:02 +0100 3362040 http://www.medworm.com/index.php?rid=3358220&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F08h00773r3j1h825%2F Abstract  Walnuts are a rich source of essential fatty acids, including the polyunsaturated fatty acids alpha-linolenic acid and linoleic acid. Essential fatty acids have been shown to modulate a number of cellular processes in the brain, including the activation state of microglia. Microglial activation can result in the generation of cytotoxic intermediates and is associated with a variety of age-related and neurodegenerative conditions. In vitro, microglial activation can be induced with the bacterial cell wall component lipopolysaccharide (LPS). In the present study, we generated a methanolic extract of English walnuts (Juglans regia) and examined the effects of walnut extract exposure on LPS-induced activation in BV-2 microglial cells. When cells were treated with walnu... Inflammation journals http://www.medworm.com/rss/comments.php?id=3358220 Wed, 10 Mar 2010 15:42:31 +0100 3358220 http://www.medworm.com/index.php?rid=3358219&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F068n3h17836t9471%2F In this study, we assessed whether the apolipoprotein B/apolipoprotein A1 ratio (ApoB/ApoA1) is related to metabolic syndrome (MS) and its components in an urban Chinese population. A total of 709 community residents were enrolled. Metabolic syndrome was defined according to the International Diabetes Federation definition in 2005. The high ApoB/ApoA1 group was defined as the gender-specific upper quartile of the ApoB/ApoA1 ratio. Insulin resistance (IR) was defined as the upper quartile of Homa-IR. The ApoB/ApoA1 ratio was significantly higher in subjects with MS, compared to those without (p < 0.05). After adjusting for age and gender, subjects with MS (odds ratio [OR] = 3.5) or IR (OR = 2.3) were more likely to be in the high ApoB/ApoA1 group. The ApoB/ApoA1 ratio in... Inflammation journals http://www.medworm.com/rss/comments.php?id=3358219 Wed, 10 Mar 2010 15:42:31 +0100 3358219 http://www.medworm.com/index.php?rid=3358221&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp67ukm4022011317%2F This study delineates that SSeCKS may be important for host defenses in spinal inflammation and suggests a valuable molecular mechanism by which astrocytes modify neuronal viability during pathological states. Content Type Journal ArticleDOI 10.1007/s10753-010-9194-3Authors Ping Wang, Nantong University Department of Immunology, Medical College Nantong 226001 People’s Republic of ChinaLinlin Sun, Nantong University Department of Immunology, Medical College Nantong 226001 People’s Republic of ChinaAiguo Shen, Nantong University Department of Immunology, Medical College Nantong 226001 People’s Republic of ChinaJunling Yang, Affiliated Hospital of Nantong University Laboratory Center Nantong 226001 People’s Republic of ChinaXiaohong Li, Nantong University The Jiangsu Province ... Inflammation journals http://www.medworm.com/rss/comments.php?id=3358221 Wed, 10 Mar 2010 15:42:29 +0100 3358221 http://www.medworm.com/index.php?rid=3358222&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx02t77w1536061t1%2F Abstract  5-Lipoxygenase inhibitor zileuton has been demonstrated to attenuate ischemic brain damage in rats of permanent focal cerebral ischemia in previous work. To further investigate the mechanism underlying zileuton's neuroprotection, adult male Sprague-Dawley rats underwent permanent middle cerebral artery occlusion (MCAO), then received treatment with zileuton or vehicle after the onset of ischemia. Neurological deficit, cerebral infarction, and morphological characteristic were measured 6 and 24 h after MCAO. The enzymatic activity of myeloperoxidase (MPO) was assessed 6 and 24 h after MCAO and the lipid peroxidation levels were evaluated by malondialdehyde assay. Expression of nuclear factor-kappa B (NF-κB) p65 in rat brain was detected by immunohistochem... Inflammation journals http://www.medworm.com/rss/comments.php?id=3358222 Wed, 10 Mar 2010 15:42:28 +0100 3358222 http://www.medworm.com/index.php?rid=3330728&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq2258553g1125753%2F Abstract  Dehydroepiandrosterone (DHEA) is considered as an important immunomodulating and anti-inflammatory hormone. Despite the continuing interest in DHEA replacement therapy, our knowledge of its effects upon asthma is very limited. DHEA is able to reverse cytokine imbalances associated with asthma, may prevent and attenuate allergic inflammation in airways, and does not possess the undesirable side effects of glucocorticoids; therefore, it may be potentially applied in the treatment of asthma. The steroid-sparing effect observed with DHEA clinically could appear especially favorable in asthmatic patients receiving oral treatment and those inhaling high doses of glucocorticoids. In addition, DHEA and its analogs might prove useful in reversing relative glucocorticoids i... Inflammation journals http://www.medworm.com/rss/comments.php?id=3330728 Tue, 02 Mar 2010 10:04:40 +0100 3330728 http://www.medworm.com/index.php?rid=3326315&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn110u27325203827%2F Abstract  Chemokines for neutrophils such as growth-related oncogene-α (GRO-α) are important in patients with refractory or severe asthma. Prostaglandin I2 (PGI2) analogues were regarded as potential treatments for asthma. Dendritic cells (DCs) are the professional antigen-presenting cells and play a critical role in regulating immune response. However, it is unknown whether PGI2 analogues have regulatory effects on GRO-α expression in human monocyte-derived DCs (MDDCs). The human MDDCs were pretreated with iloprost and treprostinil (two PGI2 analogues) or forskolin, a cyclic adenosine monophosphate (cAMP) activator, before stimulation with lipopolysaccharide (LPS). In some cases, I prostanoid (IP) receptor and E prostanoid (EP) antagonists were pretreated before PGI2 anal... Inflammation journals http://www.medworm.com/rss/comments.php?id=3326315 Mon, 01 Mar 2010 18:10:33 +0100 3326315 http://www.medworm.com/index.php?rid=3326316&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe7j5466714r5p8u3%2F In this study, we assessed the expression of survivin in rheumatoid synovial fluids (SF) and synovial tissues (ST) of rheumatoid arthritis (RA) patients in order to investigate the role of extracellular survivin in the pathogenesis of RA. The survivin level from SF was significantly higher in RA patients (n = 38) than in osteoarthritis patients (n = 18; 10.68 ± 2.76 vs. 1.0 ± 0.56 pg/ml, p = 0.02). In addition, SF survivin level was higher in erosive RA patients (n = 23) than in non-erosive RA patients (n = 15; 15.26 ± 4.26 vs. 4.47 ± 1.12 pg/ml, p = 0.05). SF survivin level in RA was positively correlated with disease activity score 28, but did not reach statistical significance (r = 0.309, p = 0.07). RA SF survivin level wa... Inflammation journals http://www.medworm.com/rss/comments.php?id=3326316 Mon, 01 Mar 2010 18:10:32 +0100 3326316 http://www.medworm.com/index.php?rid=3315902&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fkj78717440505740%2F Abstract  Acute lung injury (ALI) and the more severe acute respiratory distress syndrome (ARDS) are forms of pulmonary edema that result from robust local and systemic inflammatory states, such as sepsis. The morbidity and mortality associated with ALI and ARDS are significant and the treatment of these conditions presents a formidable challenge. Controlling hyperglycemia with insulin is a core component of patient management in the critically ill. Insulin treatment also exerts beneficial metabolic effects beyond glucose control, as well as non-metabolic effects, in insulin-resistant states. For instance, insulin inhibits NF-κB—dependent synthesis of pro-inflammatory factors and attenuates production of ROS. Indeed, intravenous administration of insulin ameliorates pulm... Inflammation journals http://www.medworm.com/rss/comments.php?id=3315902 Thu, 25 Feb 2010 17:57:02 +0100 3315902 http://www.medworm.com/index.php?rid=3310804&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx72p846261x2764m%2F This study compared the frequency of the genetic polymorphisms of tumor necrosis factor (TNF) in pulmonary tuberculosis without and with response to treatment. We carried out an observational, prospective, comparative study. Three groups were studied: healthy subjects, responders, and non-responders to directly observed treatment short-course. We took a peripheral blood sample for identification of polymorphic genotypes TNF −308G/A and lymphotoxin A (LTA) +252G/A by polymerase chain reaction, and their later digestion with the Nco1 restriction enzyme. We studied a total of 138 subjects: 42 (non-responders) and 48 in each of the remaining groups. Healthy subjects had significantly high frequency of the LTA +252A allele compared to groups of patients and could be related with protect... Inflammation journals http://www.medworm.com/rss/comments.php?id=3310804 Wed, 24 Feb 2010 06:51:59 +0100 3310804 http://www.medworm.com/index.php?rid=3310803&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff51t924w2g240578%2F The objective of this study was to investigate early effects of peritoneal inflammation on the mitochondrial function in the vital organs, liver and kidney, and their relation to inflammatory and oxidative stress mediators. The study was performed on 14 domestic pigs. Peritoneal inflammation was induced in anesthetized pigs after a midline laparotomy by autologous feces. Fluid resuscitation maintained a MAP above 60 mmHg. Animals were sacrificed 12 h later, and tissue samples were obtained to determine mitochondrial function, mRNA levels of relevant genes [inducible NO synthase (iNOS), inducible HO (HO-1), tumor necrosis factor-alpha (TNF-alpha)], generation of reactive oxygen species (ROS), and HO-1 activity. We found impaired mitochondrial function in both liver and kidne... Inflammation journals http://www.medworm.com/rss/comments.php?id=3310803 Wed, 24 Feb 2010 06:51:59 +0100 3310803 http://www.medworm.com/index.php?rid=3306091&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fvx14j8547m0g6559%2F In this study, a number of polymorphic genes coding for T-helper 1, T-helper 2, and T-regulatory cytokines were genotyped in 71 patients with IBS, and the results were compared with controls. IL-4 CC genotype at position −590, IL-4 TT genotype at position −33, and IL-10 GA genotype at position −1082 were significantly overrepresented in the patients with IBS in comparison with controls (P < 0.001). The frequencies of the following haplotypes in the patient group were significantly higher than in the control group: IL-2 (−330, +160) GT haplotype (P = 0.002), IL-4 (−1098, −590, −33) TCC haplotype (P < 0.001), and TCT haplotype (P < 0.001). While production of cytokines could be affected by genetic polymorphisms within coding and promoter regions of ... Inflammation journals http://www.medworm.com/rss/comments.php?id=3306091 Tue, 23 Feb 2010 07:51:19 +0100 3306091 http://www.medworm.com/index.php?rid=3297775&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fkq703w14g3m60097%2F In this study, we examined the biological effects of different-sized multi-walled CNTs (MWCNTs) and single-walled CNTs (SWCNTs). Long and thick MWCNTs induced the strongest DNA damage while similar SWCNTs caused little effect. Comparison of inflammatory responses of various types of CNTs found that peritoneal CNT administration of long and thick MWCNTs increased the total cell number in abdominal lavage fluid in mice. These results indicate that long and thick MWCNT, but not short and thin MWCNT, cause DNA damage and severe inflammatory effects. These findings might provide useful information for constructing novel CNTs with safety. Content Type Journal ArticleDOI 10.1007/s10753-010-9182-7Authors Kohei Yamashita, Osaka University Department of Toxicology, Graduate School of Pha... Inflammation journals http://www.medworm.com/rss/comments.php?id=3297775 Sat, 20 Feb 2010 06:53:24 +0100 3297775 http://www.medworm.com/index.php?rid=3266316&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg382115215182320%2F Abstract  The aim of this study is to explore the relationship of intrapulmonary activation of nuclear factor-κB (NF-κB) and the expression of inducible nitric oxide synthase (iNOS) mRNA with pulmonary injury in rats with severe acute pancreatitis (SAP). Fifty-four Sprague Dawley rats were randomly divided into three groups: sham operation (control) group (n = 18), SAP group (n = 18), and pyrrolindine dithiocarbamate (PDTC) pretreated group (n = 18). A SAP model was induced by retrograde injected 5% sodium taurocholate into the bile-pancreatic duct (1 ml/kg). PDTC-pretreated SAP rats were given 100 mg/kg body weight PDTC intraperitoneally before pancreatitis was induced. Six rats from each group were sacrificed at 3, 6, and 12 h after modeling. Ac... Inflammation journals http://www.medworm.com/rss/comments.php?id=3266316 Mon, 08 Feb 2010 17:31:59 +0100 3266316 http://www.medworm.com/index.php?rid=3243112&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp63806338mj83574%2F Absracts  To observe the protecting effects and mechanisms of Dexamethasone and Salviae miltiorrhizae on intestinal mucosa and immune organs (spleen, thymus and lymph node) in rats with severe acute pancreatitis (SAP). The rats were randomly divided into sham-operated, model control, Dexamethasone treated group and Salviae miltiorrhizae treated group. At 3, 6 and 12 h after operation, the mortality rate, pathological changes of intestinal mucosa and immune organs as well as the contents of serum PAF, IL-1β and sIL-2R were observed, respectively. The mortality rate and the contents of PAF (at 3 and 6 h), IL-1β (at all time points) and sIL-2R (at 3 and 6 h) as well as the pathological scores of thymus (at all time points) and spleen (at 3 h) in Dexamethas... Inflammation journals http://www.medworm.com/rss/comments.php?id=3243112 Tue, 02 Feb 2010 17:50:38 +0100 3243112 http://www.medworm.com/index.php?rid=3197138&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe466187411v37281%2F This study aimed to verify whether IL-1β -511>C/T, -31>T/C, +3953>C/T and IL1RN VNTR were associated to the development of liver cirrhosis. Two hundred forty cirrhotic patients were involved in the study. A significant trend was detected, for increasing cirrhosis frequencies, grouping the patients as follows: females and males carrying neither the IL-1β (-511 -31) T-C/T-C or T-C/(T-T or C-C) diplotypes nor any IL1RN A2 allele (138/292), males carrying either the IL-1β T-C/T-C or T-C/(T-T or C-C) diplotypes or at least one IL1RN A2 allele (74/147) and males carrying either the IL-1β T-C/T-C or T-C/(T-T or C-C) diplotypes and at least one IL1RN A2 allele (28/37) (p < 0.01). IL-1β polymorphisms are associated with the occurrence of end stage liver disease. IL-1β inf... Inflammation journals http://www.medworm.com/rss/comments.php?id=3197138 Wed, 20 Jan 2010 06:45:38 +0100 3197138 http://www.medworm.com/index.php?rid=3197139&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh44276340q315308%2F In conclusion, the present study shows the involvement of stress response proteins and mitochondrial dysfunction in LPS-induced germ cell death in male rats. Content Type Journal ArticleDOI 10.1007/s10753-009-9177-4Authors Mallikarjuna Reddy Metukuri, University of Hyderabad Department of Animal Sciences, School of Life Sciences Hyderabad AP India 500 046Chandra Mohan T. Reddy, University of Hyderabad Department of Animal Sciences, School of Life Sciences Hyderabad AP India 500 046P. R. K. Reddy, University of Hyderabad Department of Animal Sciences, School of Life Sciences Hyderabad AP India 500 046Pallu Reddanna, University of Hyderabad Department of Animal Sciences, School of Life Sciences Hyderabad AP India 500 046 Journal InflammationOnline ISSN 1573-2576Print ISSN 0360-... Inflammation journals http://www.medworm.com/rss/comments.php?id=3197139 Tue, 19 Jan 2010 17:44:48 +0100 3197139 http://www.medworm.com/index.php?rid=3193083&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx76x0426435v8j48%2F Abstract  Indomethacin is an indol derivative, non-steroidal, anti-inflammatory drug with anti-inflammatory, analgesic, and antipyretic effects. Indomethacin became the first-choice drug to produce an experimental ulcer model as a result of having a higher ulcerogenic potential than other non-steroidal anti-inflammatory drugs (NSAIDs). There have been several conflicting reports about the ulcerogenic mechanism of indomethacin; the mechanism is still unclear. It has been suggested that indomethacin induces gastric damage via inhibiting the release of protective factors like cyclooxygenase-1 (COX-1), prostaglandin E2 (PGE2), bicarbonate, and mucus; increasing aggressive factors like acid; and increasing oxidant parameters while decreasing antioxidant parameters. Classic antiu... Inflammation journals http://www.medworm.com/rss/comments.php?id=3193083 Mon, 18 Jan 2010 18:48:17 +0100 3193083 http://www.medworm.com/index.php?rid=3193084&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F657q56m7442t47j5%2F Conclusions: Considering that some works have shown CRP as an independent risk factor of CV and that statins could reduce CRP levels and prevent CV events, our findings show that some people that might benefit from the pleiotropic effect of statin remain without treatment if the decision is based only in those classical risk factors present in FRS. Content Type Journal ArticleDOI 10.1007/s10753-009-9178-3Authors Alexandre B. Rosendo, Universidade do Extremo Sul Catarinense Laboratório de Fisiopatologia Experimental Criciúma Santa Catarina BrazilLuciana O. Lima, Universidade Federal de Ciências da Saúde de Porto Alegre Laboratório de Biologia Molecular, Programa de Pós-Graduação em Ciências da Saúde Porto Alegre Rio Grande do Sul BrazilFelipe Dal-Pizzol, Universidade do Ex... Inflammation journals http://www.medworm.com/rss/comments.php?id=3193084 Mon, 18 Jan 2010 18:48:15 +0100 3193084 http://www.medworm.com/index.php?rid=3193085&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm6273w74j09j1535%2F This study provides novel observations that HNSCC cells affect monocyte phenotype and function, which are relevant to the regulation of the HNSCC microenvironment. Content Type Journal ArticleDOI 10.1007/s10753-009-9175-6Authors Aroonwan Lam-ubol, NYU College of Dentistry Oral and Maxillofacial Pathology, Radiology and Medicine 345 E. 24th St., Rm 837S (office), 1010S (lab) New York NY 10010 USADustin Hopkin, Indiana University Oral Surgery Bloomington IN USAElena M. Letuchy, University of Iowa Department of Biostatistics, College of Public Health Iowa City IA USAZoya B. Kurago, NYU College of Dentistry Oral and Maxillofacial Pathology, Radiology and Medicine 345 E. 24th St., Rm 837S (office), 1010S (lab) New York NY 10010 USA Journal InflammationOnline ISSN 1573-2576Print ISS... Inflammation journals http://www.medworm.com/rss/comments.php?id=3193085 Mon, 18 Jan 2010 18:48:14 +0100 3193085 http://www.medworm.com/index.php?rid=3171209&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv5512850jq74426h%2F Abstract  Schwann cells proliferation is the main characterize of kinds PNS inflammation diseases. It has been well documented that cyclin D3 /CDK11p58 complex inhibits cell function through multiple mechanisms, but the mechanism of cyclin D3/CDK11p58 complex exerts its repressive role in the Schwann cells proliferation remains to be identified. In the present investigation, we demonstrated that the expression of CDK11p58 were upregulated in the inflammation caused by LPS, a main part of bactria. Cyclin D3 and the 58-kDa isoform of cyclin-dependent kinase 11 (CDK11p58) interacted with each other mainly in nuclear region, repressed Schwann cells proliferation and induced cell apoptosis. Overexpression of CDK11p58 expression might enhance this process, while silence of cyclin D... Inflammation journals http://www.medworm.com/rss/comments.php?id=3171209 Mon, 11 Jan 2010 18:22:15 +0100 3171209 http://www.medworm.com/index.php?rid=3121994&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3l64361030810265%2F This study aimed to examine effects of adjunctive baicalin therapy to ampicillin for experimental bacterial meningitis in rabbits. After Escherichia Coli inoculation, mean leukocyte counts, concentrations of protein, tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1) and lactate in cerebrospinal fluid (CSF), brain water content and mean arterial and intracranial pressures substantially increased in the meningitis group. Ampicillin alone for 5 h markedly exacerbated the enhanced leukocyte counts and protein concentration, and showed no significant effect on the elevated CSF TNF-α, IL-1 and lactate concentration, mean arterial and intracranial pressures, and brain water content. Baicalin (7-D-glucuronic acid-5,6-dihydroxyflavone, C21H18O11) completely counteracted ampicillin-... Inflammation journals http://www.medworm.com/rss/comments.php?id=3121994 Wed, 23 Dec 2009 22:54:46 +0100 3121994 http://www.medworm.com/index.php?rid=3121993&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb3g5246311137683%2F Abstract  Recent research evidence shows that the receptor activator of nuclear factor-kappa B ligand (RANKL) and osteoprotegerin (OPG) play an important role in osteoclastogenesis and the inflammatory bone loss during periodontitis. Bone remodeling process is dependent on the balance of these two proteins while a high ratio of RANKL/OPG characterizes the increased osteolytic process and it has been reported in inflammatory diseases including the periodontal disease. The purpose of this study was to determine the OPG and RANKL mRNA levels in periodontal tissues derived from patients with advanced chronic periodontitis after non-surgical periodontal therapy (SRP) and to compare the RANKL/OPG ration with that in healthy persons. Gingival biopsies were obtained from subjects w... Inflammation journals http://www.medworm.com/rss/comments.php?id=3121993 Wed, 23 Dec 2009 22:54:46 +0100 3121993 http://www.medworm.com/index.php?rid=3106601&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F37mx235w58778153%2F In conclusion, in vitro we observed a non-cytotoxic effect and antiproliferative activity on the dose of 12.5 mg/dL. In vivo, this paper clarifies the great clinical relevance of the aqueous extract of U. dermestoides in elucidating its role as an anti-inflammatory agent. Content Type Journal ArticleDOI 10.1007/s10753-009-9171-xAuthors Roberto Christ Vianna Santos, Centro Universitário Franciscano (UNIFRA) Laboratório de Microbiologia Clínica Santa Maria Rio Grande do Sul BrasilAdroaldo Lunardelli, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) Laboratório de Pesquisa em Biofísica Celular e Inflamação Avenida Ipiranga 6681, prédio 12, bloco C, sala 263, CEP 90.619-900 Porto Alegre Rio Grande do Sul BrasilEduardo Caberlon, Pontifícia Universidade Católic... Inflammation journals http://www.medworm.com/rss/comments.php?id=3106601 Fri, 18 Dec 2009 07:12:13 +0100 3106601 http://www.medworm.com/index.php?rid=3063985&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000005%2Fart00013 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=3063985 Tue, 08 Dec 2009 13:38:50 +0100 3063985 http://www.medworm.com/index.php?rid=3063984&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000005%2Fart00012 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=3063984 Tue, 08 Dec 2009 13:38:50 +0100 3063984 http://www.medworm.com/index.php?rid=3063983&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000005%2Fart00011 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=3063983 Tue, 08 Dec 2009 13:38:50 +0100 3063983 http://www.medworm.com/index.php?rid=3063982&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000005%2Fart00010 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=3063982 Tue, 08 Dec 2009 13:38:50 +0100 3063982 http://www.medworm.com/index.php?rid=3063981&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000005%2Fart00009 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=3063981 Tue, 08 Dec 2009 13:38:50 +0100 3063981 http://www.medworm.com/index.php?rid=3063980&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000005%2Fart00008 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=3063980 Tue, 08 Dec 2009 13:38:50 +0100 3063980 http://www.medworm.com/index.php?rid=3063979&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000005%2Fart00007 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=3063979 Tue, 08 Dec 2009 13:38:50 +0100 3063979 http://www.medworm.com/index.php?rid=3063978&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000005%2Fart00006 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=3063978 Tue, 08 Dec 2009 13:38:50 +0100 3063978 http://www.medworm.com/index.php?rid=3063977&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000005%2Fart00005 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=3063977 Tue, 08 Dec 2009 13:38:50 +0100 3063977 http://www.medworm.com/index.php?rid=3063976&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000005%2Fart00004 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=3063976 Tue, 08 Dec 2009 13:38:50 +0100 3063976 http://www.medworm.com/index.php?rid=3063975&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000005%2Fart00003 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=3063975 Tue, 08 Dec 2009 13:38:50 +0100 3063975 http://www.medworm.com/index.php?rid=3063974&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000005%2Fart00002 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=3063974 Tue, 08 Dec 2009 13:38:50 +0100 3063974 http://www.medworm.com/index.php?rid=3063973&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000005%2Fart00001 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=3063973 Tue, 08 Dec 2009 02:31:08 +0100 3063973 http://www.medworm.com/index.php?rid=3066377&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft480h813187kg853%2F This study strongly indicated that recombinant catalase might be a potential therapy for H1N1 influenza-induced pneumonia. Content Type Journal ArticleDOI 10.1007/s10753-009-9170-yAuthors Xun-long Shi, Fudan University Department of Biosynthesis, School of Pharmacy 826 Zhangheng Road Shanghai 201203 ChinaZhi-hui Shi, Fudan University Department of Biosynthesis, School of Pharmacy 826 Zhangheng Road Shanghai 201203 ChinaHai Huang, Fudan University Department of Biosynthesis, School of Pharmacy 826 Zhangheng Road Shanghai 201203 ChinaHong-guang Zhu, Fudan University Department of Pathology, Shanghai Medical College Shanghai ChinaPei Zhou, Fudan University Department of Biosynthesis, School of Pharmacy 826 Zhangheng Road Shanghai 201203 ChinaDianwen Ju, Fudan University Department of Bi... Inflammation journals http://www.medworm.com/rss/comments.php?id=3066377 Wed, 02 Dec 2009 18:44:33 +0100 3066377 http://www.medworm.com/index.php?rid=3066378&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff8228267149j7362%2F Abstract  To study the protective role of Baicalin on rats thymus with severe acute pancreatitis (SAP). The SAP rats were randomly assigned to the model control, Baicalin treated and Octreotide treated groups. Normal rats were assigned to the sham-operated group. The rat survival rates, pathological changes of thymus, apoptotic indexes and expression levels of NF-κB, Bax, Bcl-2, Caspase-3 and P-selectin of all groups were observed and recorded at 3, 6 and 12 h after operation, respectively. Rat survival rates were significantly higher in both Baicalin- and Octreotide-treated groups than those in the model control group at 12 h (P < 0.05). The thymus pathological score was significantly lower in Baicalin treated group than in control group at 3 and 12 h ... Inflammation journals http://www.medworm.com/rss/comments.php?id=3066378 Tue, 01 Dec 2009 21:02:28 +0100 3066378 http://www.medworm.com/index.php?rid=3043900&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F38tk731k832802v8%2F Abstract  We investigated the cellular and molecular effects of ozone exposure in Cynomolgus monkeys. Thirty-six Cynomolgus monkeys were exposed to single or repeat ozone challenge. Pulmonary inflammation was assessed using bronchoalveolar lavage fluid (BAL) and histology. Gene expression profiling in lung and blood was performed. Ozone challenge evoked BAL cellular inflammation and increases in total protein, alkaline phosphatase and cytokines. Lung histology revealed cellular inflammation and epithelial necrosis. Gene expression profiling identified oxidative phosphorylation, immune response and cell adhesion pathways altered in response to ozone, with common and unique profiles in lung and blood. Lipocalin 2, CD177, the FK-506 and S100A8 binding proteins and ST-2 represe... Inflammation journals http://www.medworm.com/rss/comments.php?id=3043900 Thu, 26 Nov 2009 08:02:22 +0100 3043900 http://www.medworm.com/index.php?rid=3011643&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fyk35634274v400k1%2F This study investigates whether prolonged administration of PTX (40 mg/kg, per oral) is effective in streptozotocin-induced diabetic nephropathy. The amount of urinary protein was higher in the diabetic rats than in the control rats. The amount remained unchanged after 4 weeks and decreased after 8 weeks of PTX treatment. Accumulation of monocyte chemoattractant peptide-1 (MCP-1) and mouse monoclonal anti-monocyte/macrophage antibody (ED-1) positive cells was higher in untreated diabetic rats than in the control rats. PTX administration ameliorated the urinary MCP-1 excretion and interstitial infiltration of ED-1 positive cells at 4 weeks. Further, in diabetic rats, administration of PTX for 4 weeks inhibited the renal inflammatory reaction, and when administ... Inflammation journals http://www.medworm.com/rss/comments.php?id=3011643 Wed, 18 Nov 2009 05:18:52 +0100 3011643 http://www.medworm.com/index.php?rid=2998951&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fxr0v417884232t2h%2F Abstract  Schisantherin A, a dibenzocyclooctadiene lignan isolated from the fruit of Schisandra sphenanthera, has been used as an antitussive, tonic, and sedative agent under the name of Wuweizi in Chinese traditional medicine. In the present study, we carry out a screening program to identify the anti-inflammatory potentials of schisantherin A. We found that schisantherin A reduced lipopolysaccharide (LPS (1 mg/L))-induced levels of TNF-α, IL-6, NO, and PGE2 (p < 0.01 or p < 0.05), and also reduced levels of iNOS and COX-2 in RAW 264.7 macrophages in a concentration-dependent manner. We further investigated signal transduction mechanisms to determine how schisantherin A affects. RAW264.7 cells were pretreated with 0.5, 2.5, or 25 mg/L of schisanther... Inflammation journals http://www.medworm.com/rss/comments.php?id=2998951 Fri, 13 Nov 2009 18:28:07 +0100 2998951 http://www.medworm.com/index.php?rid=2988336&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu1703464q1584831%2F Abstract  Close physical proximity between mast cells and T cells has been demonstrated in several human conditions. We have identified and characterized a novel mast cell activation pathway initiated by contact with T cells, and showed that this pathway is associated with cytokine release. It has been shown recently that Ras is activated in this pathway. Thus, in the present study we further explore the downstream events associated with Ras activation and cytokine release in human mast cells stimulated by contact with T cells. ERK activation in human mast cells stimulated by either contact with T cells or by crosslinking the FC epsilon receptor was studied. Photobleaching experiments were used to study ERK localization. Enzyme linked immunosorbent assay was used to study t... Inflammation journals http://www.medworm.com/rss/comments.php?id=2988336 Wed, 11 Nov 2009 19:28:40 +0100 2988336 http://www.medworm.com/index.php?rid=2966553&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl264j72w38u3021q%2F Abstract   Radix Isatidis is the dried root of the plant Isatidis indigotica Fort (family Cruciferae) and traditionally used as an anti-viral, anti-bacterial, anti-endotoxic, and immune regulatory agent in the folk medicine of Korea and China. The aim of the present study was to determine the anti-inflammatory effects of methanolic extracts of Radix Isatidis (RIME) in lipopolysaccharide (LPS)-stimulated murine macrophages and in a TPA-induced ear edema animal model. Anti-inflammatory effects of RIME were examined in LPS-stimulated RAW 264.7 macrophages. In order to investigate the effects of RIME in vivo, activation of myeloperoxidase, and histological assessment were examined in the 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced mouse ear edema model. RIME significantl... Inflammation journals http://www.medworm.com/rss/comments.php?id=2966553 Tue, 03 Nov 2009 21:34:03 +0100 2966553 http://www.medworm.com/index.php?rid=2948198&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2263001wg90x083w%2F Abstract  Protein-energy malnutrition (PEM) is an important public health problem affecting millions of people worldwide. PEM decreases resistance to infection, impairing a number of physiological processes. In unstimulated cells, NF-κB is kept from binding to its consensus sequence by the inhibitor IκBα, which retains NF-κB in the cytoplasm. Upon various signals, such as lipopolysaccharide (LPS), IκBα is rapidly degraded and NF-κB is induced to translocate into the nucleus, where it activates expression of various genes that participate in the inflammatory response, including those involved in the synthesis of TNF-α. TRAF-6 is a cytoplasmic adapter protein that links the stimulatory signal from Toll like receptor-4 to NF-κB. The aim of this study was to evaluate t... Inflammation journals http://www.medworm.com/rss/comments.php?id=2948198 Thu, 29 Oct 2009 19:50:51 +0100 2948198 http://www.medworm.com/index.php?rid=2919498&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp851174615277v13%2F In conclusion, local immunostimulation at the appropriate time can enhance the host defense against bacteria in the lung. Content Type Journal ArticleDOI 10.1007/s10753-009-9158-7Authors Tanja Kerber-Momot, Medical School Hannover Institute of Functional and Applied Anatomy Carl-Neuberg Str. 1 30625 Hannover GermanyDamaris Leemhuis, Medical School Hannover Institute of Functional and Applied Anatomy Carl-Neuberg Str. 1 30625 Hannover GermanyAnke Lührmann, Medical School Hannover Institute of Functional and Applied Anatomy Carl-Neuberg Str. 1 30625 Hannover GermanyAntje Munder, Medical School Hannover Clinical Research Group, Center of Pediatrics 30625 Hannover GermanyBurkhard Tümmler, Medical School Hannover Clinical Research Group, Center of Pediatrics 30625 Hannover GermanyReinha... Inflammation journals http://www.medworm.com/rss/comments.php?id=2919498 Wed, 21 Oct 2009 05:57:58 +0100 2919498 http://www.medworm.com/index.php?rid=2915452&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk0l3l2tj50770084%2F Abstract  Interleukin-8 (IL-8), a CXC chemokine with multiple biological functions, plays an important role in the pathogenesis of oral lichen planus (OLP). The aim of this study was to investigate the association of single nucleotide polymorphisms (SNPs) of IL-8 gene with OLP in a Chinese population. Four SNPs of the IL-8 gene at positions −845 T/C (rs2227532), −738 T/A, −251 A/T (rs4073) and +781 C/T (rs2227306) were analyzed in 109 patients with OLP and 101 normal controls using polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) method. The data revealed that the −251 AA genotype and −251 A allele frequency was significantly lower in the erosive OLP (eOLP) group than in the control group (P = 0.012 and P = 0.031, respectively... Inflammation journals http://www.medworm.com/rss/comments.php?id=2915452 Tue, 20 Oct 2009 16:18:50 +0100 2915452 http://www.medworm.com/index.php?rid=2915453&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb0801867n367587p%2F In this study, we assessed the effect of GLA with that of LA on lipopolysaccharide (LPS)-induced inflammatory responses and further explored the molecular mechanism underlying the pharmacological properties of GLA in mouse RAW 264.7 macrophages. GLA significantly inhibited LPS-induced protein expression of inducible nitric oxide synthase, pro-interleukin-1β, and cyclooxygenase-2 as well as nitric oxide production and the intracellular glutathione level. LA was less potent than GLA in inhibiting LPS-induced inflammatory mediators. Both GLA and LA treatments dramatically inhibited LPS-induced IκB-α degradation, IκB-α phosphorylation, and nuclear p65 protein expression. Moreover, LPS-induced nuclear factor-κB (NF-κB) and activator protein-1 (AP-1) nuclear protein–DNA binding af... Inflammation journals http://www.medworm.com/rss/comments.php?id=2915453 Tue, 20 Oct 2009 16:18:49 +0100 2915453 http://www.medworm.com/index.php?rid=2915454&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj635k6109789345k%2F In this study, we assessed the effects and potential mechanisms of CORM-2-released CO in modulation of inflammatory response in the small intestine following I/R-challenge. To this end mice (C57Bl/6) small intestine were challenged with ischemia by occluding superior mesenteric artery (SMA) for 45 min. CORM-2 (8 mg/kg; i.v.) was administered immediately before SMA occlusion. Sham operated mice were injected with vehicle (0.25% DMSO). Inflammatory response in the small intestine (jejunum) was assessed 4 h following reperfusion by measuring tissue levels of TNF-α protein (ELISA), adhesion molecules E-selectin and ICAM-1 (Western blot), NF-κB activation (EMSA), along with PMN tissue accumulation (MPO assay) and leukocyte rolling/adhesion in the microcirculation of jejun... Inflammation journals http://www.medworm.com/rss/comments.php?id=2915454 Tue, 20 Oct 2009 16:18:46 +0100 2915454 http://www.medworm.com/index.php?rid=2908036&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6013w82245n07404%2F This study was performed to evaluate the effects of epigallocatechin 3 gallate (EGCG) on lipopolysaccharide (LPS)-induced acute lung injury in a murine model. In the present study, production of TNF-α and MIP-2 and activation of extracellular signal-regulated kinases (ERK)1/2, c-Jun amino terminal kinases (JNK) and p38 in RAW264.7 cells were measured. EGCG inhibited the production of TNF-α and MIP-2, and attenuated phosphorylation levels of ERK1/2 and JNK, but not p38 in RAW264.7 cells stimulated with LPS. Also, EGCG attenuated the production of TNF-α and MIP-2, and the phosphorylation of ERK1/2 and JNK in the lungs of mice administered with LPS intratracheally. It reduced wet/dry weight ratio, histological severities, and neutrophil accumulation in the lungs in mice given LPS. Ou... Inflammation journals http://www.medworm.com/rss/comments.php?id=2908036 Fri, 16 Oct 2009 17:58:07 +0100 2908036 http://www.medworm.com/index.php?rid=2898128&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc71756718628p2v3%2F Abstract  Maternal nutritional environmental in early life has been often associated with long term effects on the immune response in adulthood. The effects of maternal protein deprivation during early lactation on neutrophil-mediated innate immunity were investigated in adult rats, offspring of dams fed with a protein-free diet during the first days of lactation (PD), and compared to controls (22% protein diet). Inflamed PD animals showed an inhibited neutrophil migration and an impaired recruitment of leukocytes from bone marrow pool to circulation. In resting conditions, blood neutrophils from PD present reduced phagocytic activity, increased production of O2 − and NO, basal iNOS expression and constitutive NF-κB activation. Moreover, PD rats also show high circulatin... Inflammation journals http://www.medworm.com/rss/comments.php?id=2898128 Wed, 14 Oct 2009 17:08:22 +0100 2898128 http://www.medworm.com/index.php?rid=2865101&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fnw7656241m041605%2F Abstract  It is known that the loss of DC plays an important role for immune suppression during endotoxemia or sepsis. To verify our hypothesis that pre-enrichment of the lamina propria (LP) DC pool may improve protective immunity to bacterial translocation and outcome in endotoxemic mice, we pre-treated mice with Flt3L or normal saline, and then challenged them with or without LPS. Twelve hours later the population size and maturity of DC in the LP and circulation were analyzed by flow cytometry. Bacterial translocation to distant organs, inflammatory responses in the intestine and the survival rate of mice were evaluated. We observed that pretreatment of Flt3L significantly expanded DC in the LP and blood, but did not alter their maturation. However, exacerbation of DC gr... Inflammation journals http://www.medworm.com/rss/comments.php?id=2865101 Sat, 03 Oct 2009 06:35:58 +0100 2865101 http://www.medworm.com/index.php?rid=2841952&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx3716663r51w5825%2F Abstract   Ruta graveolens L. (Rutaceae) are traditionally used for the treatment of rheumatism, arthritis and other inflammatory conditions in the traditional medicine of India, were evaluated for their protective effect in acute and chronic models of inflammation. Carrageenan induced rat paw edema and adjuvant induced arthritis were employed as the experimental models of acute and chronic inflammation respectively. Isolated polyphenolic and alkaloid fraction (AFR) from Ruta graveolens and evaluated its anti inflammatory activity in carrageenan induced acute model. AFR with a dose 10 mg/kg showed higher anti inflammatory effect than polyphenols and standard drug diclofenec. AFR significantly decreased the paw edema in arthritic rats. TBARS, COX-2, 5-LOX and MPO level we... Inflammation journals http://www.medworm.com/rss/comments.php?id=2841952 Thu, 24 Sep 2009 05:51:03 +0100 2841952 http://www.medworm.com/index.php?rid=2834002&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F570l73146665q14x%2F Abstract  The hormone resistin, which was originally shown to induce insulin resistance, has been implicated in the regulation of inflammatory processes, but the molecular mechanism underlying such regulation has not been clearly defined. The goal of our study was to determine whether the expression of COX-2 can be induced by resistin and what the potential signaling pathway involved in this process is. Compared with controls, resistin significantly upregulated COX-2 expression in RAW264.7 macrophage cells. Administration of anti-resistin antibody could significantly reduce this effect. Induction of COX-2 by resistin was also markedly reduced in the presence of either dominant negative mutant IκBα or PDTC, a pharmacological inhibitor of NF-κB. On the other hand, NF-κB s... Inflammation journals http://www.medworm.com/rss/comments.php?id=2834002 Wed, 23 Sep 2009 06:05:13 +0100 2834002 http://www.medworm.com/index.php?rid=2812129&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff27pp65jxu68w57g%2F Abstract  Soluble form of the urokinase-type plasminogen activator receptor (suPAR) is markedly increased in biological fluids during different inflammatory conditions. It has previously been observed that the highest suPAR concentrations in inflammatory exudates tend to be associated with the presence of high number of neutrophils. Guided by this observation and our recent finding that activated neutrophils release suPAR we investigated whether neutrophils can be a source of suPAR during the inflammatory response in vivo. To address this question we conducted the comparative analysis of neutrophils isolated from the paired samples of synovial fluid (SF) and peripheral blood (PB) of rheumatoid arthritis patients. Freshly isolated SF neutrophils released significantly (p &... Inflammation journals http://www.medworm.com/rss/comments.php?id=2812129 Wed, 16 Sep 2009 12:51:17 +0100 2812129 http://www.medworm.com/index.php?rid=2812128&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp0r7j2804138n1m2%2F In conclusion, intrapleural fibrinolytic treatment with urokinase could enhance fibrinolytic activity and decrease TIMP-2 and RANTES production. Content Type Journal ArticleDOI 10.1007/s10753-009-9150-2Authors Jieh-Neng Wang, National Cheng Kung University Medical College Institute of Clinical Medicine Tainan 70421 TaiwanJyh-Wei Shin, National Cheng Kung University Medical College Department of Parasitology Tainan 70421 TaiwanTsuey-Yu Chang, National Cheng Kung University Medical College Department of Parasitology Tainan 70421 TaiwanJiu-Yao Wang, National Cheng Kung University Hospital Department of Pediatrics 138 Sheng Li Road Tainan 70428 TaiwanJing-Ming Wu, National Cheng Kung University Hospital Department of Pediatrics 138 Sheng Li Road Tainan 70428 Taiwan Journal Inflamm... Inflammation journals http://www.medworm.com/rss/comments.php?id=2812128 Wed, 16 Sep 2009 12:51:17 +0100 2812128 http://www.medworm.com/index.php?rid=2812127&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fphqm7363340u58n6%2F Content Type Journal ArticleCategory ErratumDOI 10.1007/s10753-009-9143-1Authors Romana Turk, University of Zagreb Department of Pathophysiology, Faculty of Veterinary Medicine Heinzelova 55 10000 Zagreb CroatiaDražen Vnuk, University of Zagreb Surgery, Orthopedics and Ophthalmology Clinic, Faculty of Veterinary Medicine Zagreb CroatiaAnte Svetina, University of Zagreb Department of Pathophysiology, Faculty of Veterinary Medicine Heinzelova 55 10000 Zagreb CroatiaZlata Flegar-Meštrić, Institute of Clinical Chemistry, Clinical Hospital “Merkur” Zagreb CroatiaMirna Robić, University of Zagreb Department of Pathophysiology, Faculty of Veterinary Medicine Heinzelova 55 10000 Zagreb CroatiaNenad Turk, University of Zagreb Department of Microbiology and Infectious Diseases with Clini... Inflammation journals http://www.medworm.com/rss/comments.php?id=2812127 Wed, 16 Sep 2009 12:51:17 +0100 2812127 http://www.medworm.com/index.php?rid=2812130&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx63582010558t723%2F Abstract   Baccharis trimera is a widespread South American plant known as “carqueja”. Medicinal teas prepared from the aerial parts of this plant are used in folk medicine in cases of liver diseases and inflammatory processes. We evaluated the effects of aqueous extract of B. trimera in the experimental inflammatory model of carrageenan-induced pleurisy in rat. The injection of carrageenan into the pleural cavity induces an influx of cells and fluid accumulation with a large number of polymorphonuclear leukocytes and increase of protein levels. The inflammation parameters were attenuated when B. trimera (400 and 800 mg/kg, i.p.) was administrated 30 min before the carrageenan. The immunomodulatory effects were evaluated in vitro on human peripheral blood monon... Inflammation journals http://www.medworm.com/rss/comments.php?id=2812130 Wed, 16 Sep 2009 12:51:15 +0100 2812130 http://www.medworm.com/index.php?rid=2812131&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe55l0185470482h3%2F Abstract  The expression of chemokines is critical in leukocyte recruitment and inflammation, but the regulatory mechanisms involved remain incompletely defined. While endocrine disrupter chemicals (EDCs) are known to be ubiquitous in the environment and often associated with altered inflammatory response, their potential impact on chemokine expression in monocytes is at present unknown. To this end, the effects of EDCs on the expression of Th1- and Th2-related chemokines in a human monocytic cell line, THP-1, were investigated. THP-1 cells were pre-treated with varying concentrations of EDCs (nonylphenol and 4-octylphenol) with or without the addition of an estrogen receptor (ER) antagonist, ICI 182,780 and then stimulated by lipopolysaccharide (LPS). The levels of chemoki... Inflammation journals http://www.medworm.com/rss/comments.php?id=2812131 Wed, 16 Sep 2009 12:51:14 +0100 2812131 http://www.medworm.com/index.php?rid=2790809&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000004%2Fart00009 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2790809 Mon, 14 Sep 2009 16:05:31 +0100 2790809 http://www.medworm.com/index.php?rid=2790808&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000004%2Fart00008 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2790808 Mon, 14 Sep 2009 16:05:31 +0100 2790808 http://www.medworm.com/index.php?rid=2790807&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000004%2Fart00007 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2790807 Mon, 14 Sep 2009 16:05:31 +0100 2790807 http://www.medworm.com/index.php?rid=2790806&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000004%2Fart00006 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2790806 Mon, 14 Sep 2009 16:05:31 +0100 2790806 http://www.medworm.com/index.php?rid=2790805&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000004%2Fart00005 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2790805 Mon, 14 Sep 2009 16:05:31 +0100 2790805 http://www.medworm.com/index.php?rid=2790804&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000004%2Fart00004 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2790804 Mon, 14 Sep 2009 16:05:31 +0100 2790804 http://www.medworm.com/index.php?rid=2790803&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000004%2Fart00003 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2790803 Mon, 14 Sep 2009 16:05:31 +0100 2790803 http://www.medworm.com/index.php?rid=2790802&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000004%2Fart00002 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2790802 Mon, 14 Sep 2009 16:05:31 +0100 2790802 http://www.medworm.com/index.php?rid=2790801&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000004%2Fart00001 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2790801 Mon, 14 Sep 2009 02:17:10 +0100 2790801 http://www.medworm.com/index.php?rid=2768343&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh024717062432702%2F Abstract  Receptors for eicosanoids such as prostaglandin E2, prostacyclin and thromboxane A2, as well as the ghrelin receptor polypeptide (GHS-R1b), can all regulate ghrelin (GHS-R1a) receptor activity, by the process of hetero-oligomerization, when heterologously expressed in human embryonic kidney (HEK 293) cells. To determine if such regulation might occur in inflammatory diseases of the vasculature, we incubated human coronary artery endothelial cells and human coronary artery smooth muscle cells with lipopolysaccharide and determined mRNA expression levels of these proteins using real-time PCR. Acute inflammation increased GHS-R1a mRNA in smooth muscle cells and increased cyclo-oxygenase-2 mRNA in endothelial cells; both these changes were attenuated by pretreatment of... Inflammation journals http://www.medworm.com/rss/comments.php?id=2768343 Thu, 03 Sep 2009 06:16:58 +0100 2768343 http://www.medworm.com/index.php?rid=2768344&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fqh2j7kr2513780v7%2F Abstract  Fibroblasts are important cells that are involved in modulation of fibrosis after injuries. In some uncontrollable inflammatory processes, excess fibroblasts migrate around the small airway. The pathogenesis of chronic obstructive pulmonary disease is related to fibrosis around the small airways. The aim of the current study was to investigate the effect of procaterol, a second-generation beta (2)-agonist, on migration of human fetal lung fibroblasts (HFL-1) induced by human plasma fibronectin (HFn). Using the blindwell chamber technique, 10−8 M procaterol inhibited migration of HFL-1 (control, 100%; 10−8 M, 73.2 ± 4.9%; n = 6, p < 0.05). The inhibitory effect of procaterol was concentration-dependent. Although a beta 2-receptor inhibit... Inflammation journals http://www.medworm.com/rss/comments.php?id=2768344 Thu, 03 Sep 2009 06:16:57 +0100 2768344 http://www.medworm.com/index.php?rid=2768345&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8551q76n43k73361%2F In this study Ang-2 was found to bind to integrin β2, and functional inhibition of integrin β2 eliminated Ang-2/PDGF-BB-mediated upregulation of monocyte fibrin invasion. Additionally, integrin β2 blockade significantly inhibited the Ang-2/PDGF-BB based increase in matrix metalloproteinase-9 (MMP-9) and membrane type-1-MMP (MT1-MMP). Furthermore, Ang-2/PDGF-BB-upregulated urokinase plasminogen-activator receptor (uPAR) was shown to be associated in complexes with integrin β2. In addition, Ang-2 was shown to upregulate PDGFR-β expression in monocytes. Therefore several components of the mechanism via which the novel interaction of Ang-2 and PDGF-BB with monocytes occurs have been identified. Content Type Journal ArticleDOI 10.1007/s10753-009-9148-9Authors Louise Bezuidenhout, ... Inflammation journals http://www.medworm.com/rss/comments.php?id=2768345 Thu, 03 Sep 2009 06:16:55 +0100 2768345 http://www.medworm.com/index.php?rid=2768346&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fnjn152wr7115620p%2F This study is to examine the role of NOD2 in the innate response of macrophages to bacterial challenge. First, peritoneal macrophages and alveolar macrophages were harvested from WT, Nod22939iC, as well as TLR4−/− mice and incubated with E. coli or P. aeruginosa. Bacterial killing activity; IL-1β and TLR4 protein expression; NF-κB DNA binding activity assay; as well as IL-1β, TNFα, TLR2, TLR4 and TLR9 mRNA expression of macrophages were examined. We found that alveolar macrophages and peritoneal macrophages of Nod22939iC mice but not WT mice or TLR4−/− mice demonstrated a significant increase of E. coli killing activity. Bacterial challenge also induced a significant increase of pro-IL-1β protein expression; NF-κB DNA binding activity; as well as IL-1β and TNFα mRNA ex... Inflammation journals http://www.medworm.com/rss/comments.php?id=2768346 Thu, 03 Sep 2009 06:16:52 +0100 2768346 http://www.medworm.com/index.php?rid=2743591&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx6705j837146473w%2F Abstract  To evaluate the anti-colitic effect of lactic acid bacteria by cDNA microarray analysis, a lactic acid bacteria mixture (LM) consisting of Lactobacillus brevis HY7401, L. suntoryeus HY7801 and Bifidobacterium longum HY8004 was orally administered to dextran sulfate (DSS)-induced colitic mice and the expression profile of numerous genes was assessed. DSS treatment caused colitic outcomes such as inflammation and colon shortening. DSS also up-regulated the expression of inflammation-related genes: pro-inflammatory and chemotactic cytokines, including IL-1β, TNF-α, IL-6, CCL2, CCL4, CCL7, CCL24, CXCL1, CXCL2, CXCL5, CXCL9 and CXCL10, and their receptors CCR3 and CCR7, and other colitis-related genes such as COX-2, PAP, MMP family, S100a8, S100a9 and DEFA1. LM treatm... Inflammation journals http://www.medworm.com/rss/comments.php?id=2743591 Thu, 27 Aug 2009 15:45:01 +0100 2743591 http://www.medworm.com/index.php?rid=2733554&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fvk7q052k3p5g73n4%2F Abstract  The effect of CO on the expression of iNOS and COX-2 was investigated by using a CO-releasing molecule (CORM)-2 in LPS-activated RAW 264.7 cells in vitro. Interestingly, CORM-2 significantly inhibited iNOS (NO) but not COX-2 (PGE2) expression. PPAR-γ activators such as troglitazone, GW1929, and 15-deoxy-Δ12, 14- prostaglandin J2 showed preferential inhibitory effect on iNOS over COX-2 expression in LPS-activated macrophages. The same effect was shown in lung tissues (iNOS, COX-2) and serum (NO, PGE2) when administered of CORM-2 in LPS-induced septic mice, indicating that CO derived from CORM-2 differentially regulates iNOS and COX-2 through PPAR-γ activation under inflammation state. Content Type Journal ArticleDOI 10.1007/s10753-009-9144-0Authors Konstantin ... Inflammation journals http://www.medworm.com/rss/comments.php?id=2733554 Mon, 24 Aug 2009 17:36:18 +0100 2733554 http://www.medworm.com/index.php?rid=2698949&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc317j878r5j354j8%2F We present evidence that periodontitis induces an increase in resting amylase activity and release without changes in isoproterenol-induced amylase secretion. Changes in amylase were reverted by the inhibition of the adenylyl cyclase by SQ 22536, the cyclooxygenase type 1 by FR 122047 and by blocking the vasoactive intestinal peptide (VIP) receptor with VIP 6–28. Parotid glands from rats with periodontitis showed an increase in cAMP levels that was also reverted in the presence of SQ 22536, FR 122047 and VIP 6–28. We concluded that both PGE2 and VIP are produced in parotid glands from rats with periodontitis and, by activating their own receptors in acinar cells, induce cAMP accumulation leading to an increase in amylase basal secretion. Content Type Journal ArticleDOI 10.1007... Inflammation journals http://www.medworm.com/rss/comments.php?id=2698949 Tue, 11 Aug 2009 01:40:28 +0100 2698949 http://www.medworm.com/index.php?rid=2688031&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl6k186g45641546l%2F Abstract  Dendirtic cells (DCs) and renin–angiotensin system (RAS) have both been reported to contribute to the pathogenesis of atherosclerosis. Recently researches find the RAS expression on DCs and its effect on DCs’ differentiation and proinflammatory function. The pattern of RAS expression on DCs derived from normal monocytes vs that on DCs derived from cornoary artery diease was investigated. In 82 coronary artery disease (CAD) patients and healthy controls (CTL), expressions of angiotensin I-converting enzyme (ACE), angiotensin AT1 receptor and DC-specific ICAM-3-grabbing nonintegrin (DC-SIGN) on DCs were measured by western-blot: CAD patients had an increased expression of ACE, AT1 receptor and DC-SIGN compared to controls especially in acute myocardial infarction... Inflammation journals http://www.medworm.com/rss/comments.php?id=2688031 Sun, 09 Aug 2009 07:16:47 +0100 2688031 http://www.medworm.com/index.php?rid=2666824&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw700340354726387%2F In this study, an in vivo model was employed whereby rats were administered an intravenous injection of oleic acid (OA, 0.1 ml/kg), and alveolar type II epithelial cells (AT-2 cells) injury was induced by hydrogen peroxide (H2O2) in vitro. OA injection resulted in lung injury and AT-2 cells apoptosis in vivo. OA injection and H2O2 upregulated FoxA1 mRNA and protein in lung tissue of the in vivo ALI model and in H2O2 challenged AT-2 cells. Overexpression of FoxA1 promoted apoptosis, whereas FoxA1 deficiency, induced by antisense oligonucleotides, decreased AT-2 cells apoptosis induced by H2O2, as shown by flow cytometry. These results suggest that FoxA1 may play an important role in ALI by promoting apoptosis of pulmonary epithelial cells. Content Type Journal ArticleDOI 10.1007/... Inflammation journals http://www.medworm.com/rss/comments.php?id=2666824 Fri, 31 Jul 2009 19:56:52 +0100 2666824 http://www.medworm.com/index.php?rid=2633729&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr57588p72x7k8q33%2F We examined the effects of salicylate on inflammation-related changes in gene or/and protein expressions of several adipokines in 3T3-L1 adipocytes and of LPS-induced inflammatory factors in RAW 264.7 cell. Especially, we focused our attention on the cross-talk between the macrophages and adipocytes. Exposure to RAW-CM medium resulted in an increase in the gene expression or/and protein secretion of TNF-α, IL-6 and resistin, and at the same time, a decrease in the gene expression of PPARγ and adiponectin in 3T3-L1 adipocytes. Salicylate effectively reversed these changes, and up-regulated glucose consumption in adipocytes. We also found salicylate inhibited phosphorylation of NF-κB in RAW-CM-stimulated adipocytes. We conclude salicylate blocks inflammatory process in the pathogene... Inflammation journals http://www.medworm.com/rss/comments.php?id=2633729 Sat, 18 Jul 2009 22:32:12 +0100 2633729 http://www.medworm.com/index.php?rid=2633730&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh7561p78742vn248%2F Abstract  Copper deficiency inactivates Cu/Zn-SOD and promotes accumulation of reactive oxygen species. This process likely impairs nitric oxide (NO)-mediated relaxation as well as triggers vascular inflammation. The current study was designed to determine whether COX-2, a proinflammatory protein, expression and activity are upregulated in the oxidative environment associated with inadequate Cu. Weanling male Sprague Dawley rats were fed purified diets which were either Cu-adequate (Cu-A); Cu-marginal (Cu-M), Cu-deficient (Cu-D), or the Cu-D diet combined with the SOD mimetic Tempol (Cu-D/T; 1 mM in drinking water) for 4 weeks. COX-2 protein, PGE2 (COX-2 metabolite) and isoprostanes (index of oxidative stress) were all higher in the Cu-D group vs Cu-A group, but no... Inflammation journals http://www.medworm.com/rss/comments.php?id=2633730 Sat, 18 Jul 2009 22:32:07 +0100 2633730 http://www.medworm.com/index.php?rid=2613410&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fhp147v3577152179%2F Abstract  Catecholamines are frequently used in sepsis, but their interaction with mitochondrial function is controversial. We incubated isolated native and endotoxin-exposed swine liver mitochondria with either dopamine, dobutamine, noradrenaline or placebo for 1 h. Mitochondrial State 3 and 4 respiration and their ratio (RCR) were determined for respiratory chain complexes I, II and IV. All catecholamines impaired glutamate-dependent RCR (p = 0.046), predominantly in native mitochondria. Endotoxin incubation alone induced a decrease in glutamate-dependent RCR compared to control samples (p = 0.002). We conclude that catecholamines and endotoxin impair the efficiency of mitochondrial complex I respiration in vitro. Content Type Journal ArticleDOI 10.1007/s107... Inflammation journals http://www.medworm.com/rss/comments.php?id=2613410 Wed, 15 Jul 2009 13:53:49 +0100 2613410 http://www.medworm.com/index.php?rid=2590910&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Frn0r186j60319304%2F Abstract  Sarcoidosis is a systemic granulomatous disease of unknown etiology characterized by activation of macrophages and T lymphocytes. Relatively little is known about the role of mast cells and their mediators in the pathogenesis of sarcoidosis. Tryptase is an enzyme produced by activated mast cells, regarded as a marker of mast cell activation. To analyse tryptase concentrations in serum of sarcoidosis patients in an attempt to define the role of tryptase and mast cells in the pathogenesis of sarcoidosis and to evaluate the potential of tryptase as marker of disease severity. Quantitative analysis of tryptase concentrations was performed in serum of patients with stable sarcoidosis (n = 12), progressive sarcoidosis (n = 23) and controls (n = 13). Patients ... Inflammation journals http://www.medworm.com/rss/comments.php?id=2590910 Tue, 07 Jul 2009 15:42:02 +0100 2590910 http://www.medworm.com/index.php?rid=2579737&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl8q06l25h5m57l76%2F Content Type Journal ArticleCategory Retraction NoteDOI 10.1007/s10753-009-9134-2Authors Eva Haker, Department of Physical Therapy Stockholm SwedenElvar Theodorsson, University Hospital Department of Clinical Chemistry Linkoping SwedenThomas Lundeberg, Karolinska Institutet Physiology and Pharmacology Stockholm Sweden Journal InflammationOnline ISSN 1573-2576Print ISSN 0360-3997 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2579737 Mon, 06 Jul 2009 16:17:23 +0100 2579737 http://www.medworm.com/index.php?rid=2563773&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000003%2Fart00009 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2563773 Sun, 05 Jul 2009 10:34:10 +0100 2563773 http://www.medworm.com/index.php?rid=2563772&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000003%2Fart00008 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2563772 Sun, 05 Jul 2009 10:34:10 +0100 2563772 http://www.medworm.com/index.php?rid=2563771&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000003%2Fart00007 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2563771 Sun, 05 Jul 2009 10:34:10 +0100 2563771 http://www.medworm.com/index.php?rid=2563770&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000003%2Fart00006 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2563770 Sun, 05 Jul 2009 10:34:10 +0100 2563770 http://www.medworm.com/index.php?rid=2563769&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000003%2Fart00005 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2563769 Sun, 05 Jul 2009 10:34:10 +0100 2563769 http://www.medworm.com/index.php?rid=2563768&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000003%2Fart00004 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2563768 Sun, 05 Jul 2009 10:34:10 +0100 2563768 http://www.medworm.com/index.php?rid=2563767&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000003%2Fart00003 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2563767 Sun, 05 Jul 2009 10:34:10 +0100 2563767 http://www.medworm.com/index.php?rid=2563766&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000003%2Fart00002 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2563766 Sun, 05 Jul 2009 10:34:10 +0100 2563766 http://www.medworm.com/index.php?rid=2563765&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000003%2Fart00001 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2563765 Sun, 05 Jul 2009 02:15:07 +0100 2563765 http://www.medworm.com/index.php?rid=2569242&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm6m1571278636457%2F In conclusion, ω−3 FAs supplemented PN can elevate the IL-10 level and HLA-DR expression in SAP patients. A larger trial is required to see whether ω−3 FAs supplemented PN treatment in SAP patients would result in better clinical outcomes than ω−6 FAs. Content Type Journal ArticleDOI 10.1007/s10753-009-9136-0Authors Xinying Wang, Medical School of Nanjing University Research Institute of General Surgery, Jinling Hospital Nanjing ChinaWeiqin Li, Jinling Hospital Research Institute of General Surgery Nanjing ChinaFeng Zhang, Jinling Hospital Research Institute of General Surgery Nanjing ChinaLiya Pan, Jinling Hospital Research Institute of General Surgery Nanjing ChinaNing Li, Jinling Hospital Research Institute of General Surgery Nanjing ChinaJieshou Li, Medical School of Na... Inflammation journals http://www.medworm.com/rss/comments.php?id=2569242 Wed, 01 Jul 2009 06:19:18 +0100 2569242 http://www.medworm.com/index.php?rid=2569243&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fvm3567580n097118%2F Content Type Journal ArticleCategory Retraction NoteDOI 10.1007/s10753-009-9133-3Authors Eva Haker, Department of Physical Therapy Stockholm SwedenElvar Theodorsson, University Hospital Department of Clinical Chemistry Linkdping SwedenThomas Lundeberg, Physiology and Pharmacology Karolinska Institutel Stockholm Sweden Journal InflammationOnline ISSN 1573-2576Print ISSN 0360-3997 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2569243 Wed, 01 Jul 2009 06:19:15 +0100 2569243 http://www.medworm.com/index.php?rid=2503752&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fvq5770k227044q85%2F Abstract  β4 Galactosylation of glycoproteins is one of the most important post-translational modifications. Recent studies have demonstrated that aberrant galactosylation associates with some inflammation diseases. β-1,4-galactosyltransferase-I (β-1,4-GalT-I), which transfers galactose to the terminal N-acetylglucosamine of N- and O-linked glycans in a β-1,4- linkage, considered to be the major galactosyltransferse among the seven members of the subfamily responsible for β4 galactosylation. In the present study, we investigated the expression of β-1,4-GalT-I in Schwann cells under Lipopolysaccharide (LPS) treatment. RT-PCR revealed that the β-1,4-GalT-I mRNA was significant increased as early as 2 h after LPS stimulation. Immunofluorescence showed that β-1,4-Ga... Inflammation journals http://www.medworm.com/rss/comments.php?id=2503752 Tue, 23 Jun 2009 06:09:10 +0100 2503752 http://www.medworm.com/index.php?rid=2503751&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd4252q8223716763%2F Abstract  There is ample evidence that asthma is mediated by oxidative stress and that viral infection, which is associated with asthma onset and exacerbation in infants, acts as one type of oxidative stress. The goal of this study was to determine whether respiratory syncytial virus (RSV) induces oxidative stress in cultured A549 human airway epithelial cells and normal human bronchial epithelial cells (NHBE), and whether such RSV-induced oxidative stress can induce airway inflammation. To evaluate the direct effect of RSV infection as an oxidative stressor, the intracellular levels of reduced glutathione (GSH) or oxidized glutathione (GSSG) were measured. Their ratio (GSH/GSSG) was calculated to indicate intracellular oxidation–reduction (redox) status in A549 and NHBE.... Inflammation journals http://www.medworm.com/rss/comments.php?id=2503751 Tue, 23 Jun 2009 06:09:10 +0100 2503751 http://www.medworm.com/index.php?rid=2503754&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw783q6g061588015%2F Abstract  Alveolar macrophages (AM) are the primary target cell of the lung for inhaled mycobacterial pathogens. We investigated the effect of the synthetic lipopeptide MALP-2 on the interaction between AM from rats and Mycobacterium bovis BCG. AM were infected with M. bovis BCG at a multiplicity of infection (MOI) of 10 and then cultured in medium alone or medium supplemented with either synthetic macrophage activating lipopeptide-2 (MALP-2), or IFN-γ, or both. Mycobacterial CFU were counted on days 3 and 7 and cell-free supernatants were collected for cytokine measurements. Treatment of macrophages with MALP-2 led to reduced bacterial loads by day 3 and 7 post-infection and at the same time enhanced the release of TNF-α, IL-6 und IL-10 compared to non-stimulated... Inflammation journals http://www.medworm.com/rss/comments.php?id=2503754 Fri, 19 Jun 2009 06:47:15 +0100 2503754 http://www.medworm.com/index.php?rid=2503753&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe02v7l11563105qv%2F Abstract  To investigate the effect of apoptosis about Salvia miltiorrhizae injection on the lungs of SAP and OJ rats. Total 288 rats were used for SAP-associated experiments and OJ-associated experiments, respectively. The rats were randomly divided into sham-operated, model control and treated group. According to the difference of time points after operation, the SAP rats in each group were subdivided into 3, 6 and 12 h groups while the OJ rats were divided into 7, 14, 21 and 28 days groups. The pathological changes, expression levels of Bax protein and apoptotic indexes in the lungs of SAP or OJ rats were observed, and the mortality rates of SAP or OJ rats were recorded, respectively. The numbers of dead SAP and OJ rats in treated groups declined. The pathologi... Inflammation journals http://www.medworm.com/rss/comments.php?id=2503753 Fri, 19 Jun 2009 06:47:15 +0100 2503753 http://www.medworm.com/index.php?rid=2503755&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9357003455737748%2F Abstract  The effects of brown coal derived potassium humate on lymphocyte proliferation, cytokine production and complement activation were investigated in vitro. Potassium humate increased lymphocyte proliferation of phytohaemaglutinin A (PHA) and pokeweed mitogen (PWM) stimulated mononuclear lymphocytes (MNL) in vitro from concentrations of 20 to 80 μg/ml, in a dose dependant manner. On the other hand potassium humate, at 40 μg/ml, significantly inhibited the release of TNF-α, IL-1β, IL-6 and IL-10 by PHA stimulated MNL. Regarding complement activation it was found that potassium humate inhibits the activation of both the alternative and classical pathways without affecting the stability of the red blood cell membranes. These results indicate that the anti-i... Inflammation journals http://www.medworm.com/rss/comments.php?id=2503755 Tue, 09 Jun 2009 16:11:13 +0100 2503755 http://www.medworm.com/index.php?rid=2503756&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F15378432l7102883%2F In conclusion, Tec kinase may mediate the transcription of IL-8 in monocyte stimulated with LPS. Content Type Journal ArticleDOI 10.1007/s10753-009-9129-zAuthors Guang-Qing Wang, Second Military Medical University Institute of Burn Surgery, Changhai Hospital 174 Changhai Road Shanghai 200433 People’s Republic of ChinaXiao-Yan Yang, Second Military Medical University Institute of Burn Surgery, Changhai Hospital 174 Changhai Road Shanghai 200433 People’s Republic of ChinaYi-Tao Jia, Second Military Medical University Institute of Burn Surgery, Changhai Hospital 174 Changhai Road Shanghai 200433 People’s Republic of ChinaZhao-Fan Xia, Second Military Medical University Institute of Burn Surgery, Changhai Hospital 174 Changhai Road Shanghai 200433 People’s Republic of China ... Inflammation journals http://www.medworm.com/rss/comments.php?id=2503756 Tue, 09 Jun 2009 16:11:12 +0100 2503756 http://www.medworm.com/index.php?rid=2458593&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000002%2Fart00009 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2458593 Sun, 07 Jun 2009 15:24:43 +0100 2458593 http://www.medworm.com/index.php?rid=2458592&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000002%2Fart00008 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2458592 Sun, 07 Jun 2009 15:24:43 +0100 2458592 http://www.medworm.com/index.php?rid=2458591&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000002%2Fart00007 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2458591 Sun, 07 Jun 2009 15:24:43 +0100 2458591 http://www.medworm.com/index.php?rid=2458590&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000002%2Fart00006 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2458590 Sun, 07 Jun 2009 15:24:43 +0100 2458590 http://www.medworm.com/index.php?rid=2458589&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000002%2Fart00005 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2458589 Sun, 07 Jun 2009 15:24:43 +0100 2458589 http://www.medworm.com/index.php?rid=2458588&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000002%2Fart00004 This article is currently available as a free download on IngentaConnect (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2458588 Sun, 07 Jun 2009 15:24:43 +0100 2458588 http://www.medworm.com/index.php?rid=2458587&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000002%2Fart00003 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2458587 Sun, 07 Jun 2009 15:24:43 +0100 2458587 http://www.medworm.com/index.php?rid=2458586&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000002%2Fart00002 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2458586 Sun, 07 Jun 2009 15:24:43 +0100 2458586 http://www.medworm.com/index.php?rid=2458585&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000002%2Fart00001 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2458585 Sun, 07 Jun 2009 02:13:32 +0100 2458585 http://www.medworm.com/index.php?rid=2455936&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9437q45253242354%2F The objective of the recent study was to determine blood rheological profile in patients with AD at different clinical stages. Blood rheology, as estimated by blood viscosity as well as deformability (elongation index—EI) and aggregation of erythrocytes (aggregation half time (AT1/2)—expressing the kinetic aspects and syllectogram amplitude (AMP)—representing total aggregation extent) were measured in 25 female AD patients, who showed clinical features of mild to severe AD and in 14 healthy subjects. There were no significant differences in blood rheological properties between patients with mild AD and the controls. A significant decrease in erythrocytes AT1/2 and AMP as well as EI were observed in severe AD patients as compared to other groups. Whole blood and plasma viscosity... Inflammation journals http://www.medworm.com/rss/comments.php?id=2455936 Tue, 02 Jun 2009 08:11:28 +0100 2455936 http://www.medworm.com/index.php?rid=2432114&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2666k04026107g3l%2F Abstract  Aspirin is an anti-inflammatory drug, and has been widely used for the prevention of cardio-cerebrovascular events. Matrix metalloproteinase (MMP)-2 and MMP-9 can degrade the extracellular matrix and may be critical for the development and disruption of atherosclerotic plaques, while tissue inhibitor of metalloproteinase (TIMP)-1 may inhibit the degradation of extracellular matrix. The purpose of present study was to investigate the inhibitory effects of aspirin on MMP-2 and MMP-9 expression and activity in cultured mouse celiac macrophages, and to determine the possible mechanisms. The results showed that MMP-2/9 mRNA expression and release were significantly decreased after cultured mouse celiac macrophages were treated with aspirin 12.5–50 μg/ml for 24&... Inflammation journals http://www.medworm.com/rss/comments.php?id=2432114 Fri, 22 May 2009 05:47:55 +0100 2432114 http://www.medworm.com/index.php?rid=2422723&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh24681662q7391x2%2F Abstract  Expression of neurokinin-1 (NK-1, substance P receptor) is increased in the airway epithelium of asthmatic subjects who demonstrate the presence of Mycoplasma pneumoniae in their airways by polymerase chain reaction. M. pneumoniae exposure may increase preprotachykinin-A mRNA expression (PPT-A, the precursor to substance P) and protein expression of substance P and NK-1 from human airway epithelial cells. Normal human bronchial epithelial cells (NHBE) were cultured and exposed to M. pneumoniae for 48 h at concentrations of ten, 20 and 50 colony forming units/ml in the presence and absence of an anti-P1 adhesin antibody that blocks M. pneumoniae binding. Real time PCR for PPT-A was performed, the results were expressed as fold change over negative control. Prote... Inflammation journals http://www.medworm.com/rss/comments.php?id=2422723 Sat, 16 May 2009 06:02:33 +0100 2422723 http://www.medworm.com/index.php?rid=2422724&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa2qpk0442h501467%2F Abstract  To observe the protective effects of Salvia miltiorrhizae injection on multiple organs of rats with SAP or OJ. Two hundred eighty-eight rats were used for SAP-associated experiments and OJ-associated experiments. The rats were randomly divided into sham-operated, model control and treated group. According to the different time points after operation, the SAP rats in each group were subdivided into 3, 6 and 12 h groups while the OJ rats were divided into 7, 14, 21 and 28 days groups. The mortality rates, pathological changes and ICAM-1 (only in lung), TLR4 (only in liver), Bax and NF-κB proteins expression in multiple organs (liver, kidney, lung, intestinal mucosa, spleen, thymus and lymph nodes) were observed, respectively. The mortality rates of treate... Inflammation journals http://www.medworm.com/rss/comments.php?id=2422724 Tue, 12 May 2009 06:05:26 +0100 2422724 http://www.medworm.com/index.php?rid=2396743&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe830882p2677727k%2F Abstract   Cudrania tricuspidata is one of the most omnipresent traditional herbal drugs for anti-inflammation and anti-tumor. The purpose of the present study was to determine whether the CTB glycoprotein regulates the inflammatory reaction stimulated by bisphenol A (BPA) in human mast cells (HMC-1). Thus, we investigated that CTB glycoprotein inhibits the degranulation of histamine, expression of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK), as a mitogen activated protein (MAP) kinase, nuclear transcription factors involving nuclear factor (NF)-κB and Activator protein (AP)-1, cyclooxygenase (COX)-2. The results indicated that CTB glycoprotein decreased gene expression of cytokines of IL-4, IFN-γ, interleukin (IL)-1β and cyclooxygenase ... Inflammation journals http://www.medworm.com/rss/comments.php?id=2396743 Tue, 05 May 2009 05:51:42 +0100 2396743 http://www.medworm.com/index.php?rid=2380043&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F56467012h3p52137%2F Abstract  The aim of this study was determined the expression of pro inflammatory cytokines in prostate epithelial cells. Furthermore, we analysed the relation between these cytokines and sera PSA levels according the three groups: 0–4, 4–20 and >20 ng/mL. The study was carried out in five normal prostate (NP), 27 benign prostate hyperplastic (BPH) and 18 prostate cancer (PC). Immunohistochemical and Western blot analysis was performed. Serum levels of PSA were assayed by Immulite autoanalyser. The western Blotting analysis revealed an immunoexpression of IL-1α, IL-6 and TNFα in BPH and PC. IL-1α, was absent in NP. Immunohistochemical analysis showed significant high optical density to IL-1α and IL-6 in cancer epithelial cells (19.45 ± 3.25 and 26.2 ±... Inflammation journals http://www.medworm.com/rss/comments.php?id=2380043 Tue, 28 Apr 2009 13:23:17 +0100 2380043 http://www.medworm.com/index.php?rid=2374198&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp4vq570548t321t5%2F Abstract  To determine its relationship with acute cholangitis (AC), we sought to quantify expression of triggering receptor expressed on myeloid cells (TREM-1) in peripheral blood mononuclear cells (PBMC) of sepsis patients with AC. Peripheral blood samples of 42 AC patients and 48 patients with AC of severe type (ACST) were collected from January to September, 2008 and tested for TREM-1 mRNA by RT-PCR and protein expression by immunocytochemistry and Western blotting. ELISA and immunoturbidimetry were employed to detect the changes of TNF-α or C-reactive protein in the serum respectively. TREM-1 expression was higher in ACST group than in AC group (P < 0.01). TREM-1 was positive in mononuclear cells by immunochemistry in both groups before operative therapy, but th... Inflammation journals http://www.medworm.com/rss/comments.php?id=2374198 Sat, 25 Apr 2009 07:18:05 +0100 2374198 http://www.medworm.com/index.php?rid=2366935&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd8t3hnn70n2m7r11%2F Abstract  We investigated the effects of Baicalin and Octreotide on the levels of endotoxin and TNF-α in blood and the effects of apoptotic changes in multiple organs of SAP rats, and explored the underlying therapeutic mechanisms of Baicalin and Octreotide. In this study, 135 SAP rats were randomly divided into model control, Baicalin treated and Octreotide treated group (n = 45), respectively, the same number of normal rats were included in sham-operated group (n = 45). The above-mentioned groups were further subdivided into 3, 6 and 12 h subgroups, respectively (15 rats in each subgroup). At 3, 6 and 12 h after operation, the mortality rate of rats, endotoxin and TNF-α levels in blood as well as the pathological severity scores, expression levels of Bax... Inflammation journals http://www.medworm.com/rss/comments.php?id=2366935 Thu, 23 Apr 2009 08:14:07 +0100 2366935 http://www.medworm.com/index.php?rid=2353016&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F34m571281432j34p%2F Abstract  High levels of CRP relate with advanced disease and poor prognosis of cancer patients. CRP serum levels were measured in 684 cancer patients who had undergone complete surgery or inoperable patients. Patients with inoperable tumors had significantly higher CRP levels (1.21 ± 2.2 vs. 0.40 ± 0.4 mg/dL; p < 0.0001). No association with gender, diabetes, autoimmune disease, thyroid disease or allergy was noted. Significantly higher CRP levels were noted in operated patients with hypertension (0.55 ± 0.5 vs. 0.35 ± 0.4; p = 0.001), coronary disease (0.73 ± 0.8 vs. 0.39 ± 0.4; p = 0.01) and obesity (0.51 ± 0.5 vs. 0.37 ± 0.4; p = 0.04). On the contrary, analysis in the group of inoperable patients showed that ... Inflammation journals http://www.medworm.com/rss/comments.php?id=2353016 Fri, 17 Apr 2009 07:27:23 +0100 2353016 http://www.medworm.com/index.php?rid=2346668&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3w05057u84328111%2F Abstract  To investigate the effect of salvia miltiorrhizae on the expressions of TLR4 protein in the liver of rats with severe acute pancreatitis (SAP) and obstructive jaundice (OJ), and explore the protective mechanism of salvia miltiorrhizae on the liver of rats. A total of 288 mice was used in SAP- (n = 108) and OJ-associated experiments (n = 180). The rats were randomly divided into sham-operated, model control and treated group. Based on the different time points after operation, these groups were subdivided into 3, 6 and 12 h subgroups (SAP rats, n = 12) or 7, 14, 21 and 28 days subgroups (OJ rats, n = 15). At the corresponding time points after operation, blood and liver specimens were collected to determine the contents of endotoxin and TNF-... Inflammation journals http://www.medworm.com/rss/comments.php?id=2346668 Thu, 16 Apr 2009 05:49:04 +0100 2346668 http://www.medworm.com/index.php?rid=2346667&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk0t56h0426363426%2F This study was to investigate the expression profile of IFN-γ and IL-4 in saliva of OLP patients. Seventy-nine ethnic Chinese patients with OLP were recruited for this study, together with 41 age–sex-matched healthy volunteers served as control group. IFN-γ and IL-4 levels in whole unstimulated saliva were screened by enzyme linked immunosorbent assay. OLP patient showed a low-level IFN-γ but high-level IL-4 expression profile in saliva, with a lower ratio of salivary IFN-γ/IL-4 compared to healthy controls. With regards to subtypes, salivary IL-4 level in erythematous/ulcerative group was significantly higher than that in reticular group. Imbalance of Th1/Th2 cytokines with Th2-predominant profile in saliva may be involved in OLP. Salivary IL-4 level may be a fine biomarker re... Inflammation journals http://www.medworm.com/rss/comments.php?id=2346667 Thu, 16 Apr 2009 05:49:04 +0100 2346667 http://www.medworm.com/index.php?rid=2339994&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4l37wk734345285g%2F This study examines the influence of chronic cigarette smoking on the expression of CCL18 by AM. Bronchoalveolar lavage (BAL) and serum were obtained from ten smokers and 14 non-smokers. CCL18 protein concentrations were measured in serum and BAL fluid (BALF) as well as in supernatants from BAL-cells by enzyme-linked immunosorbent assay. In this study we show that the CCL18 production of BAL-cells from smokers was significantly decreased compared to BAL-cells from non-smokers. The BALF CCL18 protein concentration per macrophage cell count was significantly reduced in smokers. Furthermore, we show a decrease in CCL18 production from BAL-cells after stimulation with LPS. This decrease in CCL18 production was only shown in BAL-cells from non-smokers, which is probably due to chronic LP... Inflammation journals http://www.medworm.com/rss/comments.php?id=2339994 Thu, 09 Apr 2009 07:07:53 +0100 2339994 http://www.medworm.com/index.php?rid=2339995&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb67667158w7351v6%2F Abstract  The aim of this study was to evaluate the inflammatory response after total splenectomy and spleen autotransplantation in a porcine model by measuring serum platelet-activating factor acetylhydrolase activity, C-reactive protein and albumin concentrations. Nineteen piglets were used in the experiment. After induction of anesthesia, animals were randomly divided into three groups: sham-operation with spleens intact (n = 6), total splenectomy (n = 6), and splenic autotransplantation (n = 7) with small fragments of the spleen autotransplanted into the greater omentum. The blood samples were taken just before surgery and on day 1st, 5th, 12th, 26th and 40th postoperatively. PAF-AH activity, CRP and albumin concentrations were assayed in the sera. After tota... Inflammation journals http://www.medworm.com/rss/comments.php?id=2339995 Wed, 08 Apr 2009 08:22:59 +0100 2339995 http://www.medworm.com/index.php?rid=2283079&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx804675761132666%2F Abstract  The success of anti-tumor necrosis factor alpha (TNFα) therapies has led to increased interest as to the mechanisms and consequences of TNFα blockade. The aim of the study was to examine the effects of TNFα blockade by etanercept on lipopolysaccharide (LPS) or peptidoglycan (PG)-induced maturation of human monocyte-derived dendritic cells (MDDCs). MDDCs grown from peripheral blood of healthy donors were stimulated by LPS or PG with/without the presence of etanercept. Concentrations of TNFα in cell supernatants were assessed by ELISA, while the cells were stained with monoclonal antibodies to CD83, CD80, CD86, CD11c, CD40, HLA-DR, and annexin-V and acquired using a flow cytometer. Etanercept significantly decreased the stimulated cell surface expression of HLA-... Inflammation journals http://www.medworm.com/rss/comments.php?id=2283079 Fri, 20 Mar 2009 10:23:22 +0100 2283079 http://www.medworm.com/index.php?rid=2257935&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc118u060t451x315%2F Abstract  Tumour necrosis factor α (TNF-α) is a proinflammatory cytokine, which has been shown to be a causative factor in rheumatoid arthritis, inflammatory bowel disease and septic shock. Proinflammatory effect of TNF-α is activated mainly through human TNF receptor-1 (TNF-R1). However, the role of the fourth cystein-rich domain (CRD4) of TNF-R1 extracellular portion in the interaction of TNF-α with TNF-R1 is still unclear. In the present study, binding activity of TNF-α to TNF-R1 and protein levels of IκB-α and nuclear transcription factor kappa B (NF-κB) p65 subunit in HeLa cells were measured using enzyme-linked immunosorbent assay (ELISA) and western-blot analysis. Pep 3 (LRENECVS) which was derived from the hydrophilic region of A1 module in CRD4 remarkably i... Inflammation journals http://www.medworm.com/rss/comments.php?id=2257935 Tue, 10 Mar 2009 08:02:46 +0100 2257935 http://www.medworm.com/index.php?rid=2239386&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000001%2Fart00011 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2239386 Sat, 07 Mar 2009 01:50:52 +0100 2239386 http://www.medworm.com/index.php?rid=2239385&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000001%2Fart00010 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2239385 Sat, 07 Mar 2009 01:50:52 +0100 2239385 http://www.medworm.com/index.php?rid=2239384&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000001%2Fart00009 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2239384 Sat, 07 Mar 2009 01:50:52 +0100 2239384 http://www.medworm.com/index.php?rid=2239383&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000001%2Fart00008 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2239383 Sat, 07 Mar 2009 01:50:52 +0100 2239383 http://www.medworm.com/index.php?rid=2239382&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000001%2Fart00007 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2239382 Sat, 07 Mar 2009 01:50:52 +0100 2239382 http://www.medworm.com/index.php?rid=2239381&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000001%2Fart00006 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2239381 Sat, 07 Mar 2009 01:50:52 +0100 2239381 http://www.medworm.com/index.php?rid=2239380&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000001%2Fart00005 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2239380 Sat, 07 Mar 2009 01:50:52 +0100 2239380 http://www.medworm.com/index.php?rid=2239379&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000001%2Fart00004 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2239379 Sat, 07 Mar 2009 01:50:52 +0100 2239379 http://www.medworm.com/index.php?rid=2239378&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000001%2Fart00003 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2239378 Sat, 07 Mar 2009 01:50:52 +0100 2239378 http://www.medworm.com/index.php?rid=2239377&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000001%2Fart00002 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2239377 Sat, 07 Mar 2009 01:50:52 +0100 2239377 http://www.medworm.com/index.php?rid=2239376&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2009%2F00000008%2F00000001%2Fart00001 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2239376 Sat, 07 Mar 2009 01:50:52 +0100 2239376 http://www.medworm.com/index.php?rid=2217112&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7w47255g4r037t63%2F This study has shown that hTFF3 may have therapeutic potential in the treatment of inflammatory bowel disease, and one of the mechanisms may related to inhibit the TLR4/NF-κB signaling pathways. Content Type Journal ArticleDOI 10.1007/s10753-009-9110-xAuthors Xu Teng, Shengjing Hospital Of China Medical University Department of Pediatric Gastroenterology Shenyang 110004 Liaoning ChinaLing-Fen Xu, Shengjing Hospital Of China Medical University Department of Pediatric Gastroenterology Shenyang 110004 Liaoning ChinaPing Zhou, Shengjing Hospital Of China Medical University Department of Pediatric Gastroenterology Shenyang 110004 Liaoning ChinaHong-Wei Sun, Shengjing Hospital Of China Medical University Department of Pediatric Gastroenterology Shenyang 110004 Liaoning ChinaMei Sun, Shen... Inflammation journals http://www.medworm.com/rss/comments.php?id=2217112 Tue, 24 Feb 2009 09:36:48 +0100 2217112 http://www.medworm.com/index.php?rid=2217111&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7542v741312l7203%2F Abstracts  To study the efficacy and mechanism of Salvia miltiorrhizae injection in the treatment of severe acute pancreatitis. SAP rat models were prepared and randomly divided into model control group and treated group. The sham-operated group was also set. At 3, 6 and 12 h after operation, the mortality rate, ascitic volumes, pathological changes in the pancreas, contents of amylase and endotoxin in plasma as well as IL-6, IL-18, ET-1 and NO in serum, the staining intensity of Bax and NF-κB p56 proteins, and the changes in apoptosis index of pancreatic cells in rats in each group were observed. The pathological severity scores (at 3, 6 and 12 h after operation), contents of plasma endotoxin (at 6 and 12 h after operation) and serum IL-6 (at 6 and 12 ... Inflammation journals http://www.medworm.com/rss/comments.php?id=2217111 Tue, 24 Feb 2009 09:36:48 +0100 2217111 http://www.medworm.com/index.php?rid=2217110&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp0321353336118t4%2F This study was designed to determine the effects of various resuscitation fluids on intestinal injuries after hemorrhagic shock and resuscitation (HS/R) and to determine the potential mechanisms. We induced HS by bleeding male Sprague-Dawley rats to a blood pressure of 30 to 40 mmHg for 60 min. Sixty minutes later, the rats were killed (HS group) or immediately resuscitated with L-isomer lactated Ringer’s solution (HS + LR group), shed blood (HS + BL group), or hydroxyethyl starch (HS + HES group) to maintain the blood pressure to the original value during the 60-min resuscitation period. Three hour after resuscitation, bacterial translocation (BT), intestinal permeability, ileal levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, malondialdehyde (MDA), oxidized... Inflammation journals http://www.medworm.com/rss/comments.php?id=2217110 Tue, 24 Feb 2009 09:36:48 +0100 2217110 http://www.medworm.com/index.php?rid=2217109&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy78p8p432tq30u5j%2F In conclusion, we used a human WB model that takes into consideration relevant in vivo immune cell interactions in the presence of plasma proteins to show that TC, doxy, and CMT-3 can reduce the production of pro-inflammatory mediators. This property may contribute to the clinically proven benefits of these molecules in the treatment of periodontitis and other chronic inflammatory diseases. Content Type Journal ArticleDOI 10.1007/s10753-009-9111-9Authors Julia Cazalis, Université Laval Groupe de Recherche en Écologie Buccale, Faculté de Médecine Dentaire Quebec City Quebec G1K 7P4 CanadaShin-ichi Tanabe, Université Laval Groupe de Recherche en Écologie Buccale, Faculté de Médecine Dentaire Quebec City Quebec G1K 7P4 CanadaGuy Gagnon, Université Laval Groupe de Recherche en... Inflammation journals http://www.medworm.com/rss/comments.php?id=2217109 Tue, 24 Feb 2009 09:36:48 +0100 2217109 http://www.medworm.com/index.php?rid=2195168&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa2w8n340215u6t40%2F Abstract  It has been well established that diet high in cholesterol and saturated fatty acids could significantly elevate plasma cholesterol levels and also increase the risk of cardiovascular diseases. We hypothesize that repeated systemic Escherichia coli (E. coli) in conjunction with hypercholesterolemia, leads to development of oxidative stress that may affect the development and progression of inflammatory CVD. Swiss albino mice (4 weeks old) were randomly assigned to high cholesterol diet (HCD) or normal laboratory diet (NLD) groups. At 10 weeks of age, mice were inoculated intravenously with E. coli or vehicle for 24 weeks. Serum cholesterol, low density lipoprotein, C reactive protein levels, blood glucose level and selective antioxidant enzymes throug... Inflammation journals http://www.medworm.com/rss/comments.php?id=2195168 Tue, 17 Feb 2009 13:34:08 +0100 2195168 http://www.medworm.com/index.php?rid=2188306&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg5002444g1326m63%2F In conclusion, the inhalation of CO protected mice from the synovial inflammation of CIA. Based on these data, the beneficial effects of CO in murine RA model may be attributed to its anti-inflammatory properties. Content Type Journal ArticleDOI 10.1007/s10753-009-9106-6Authors Tomohisa Takagi, Kyoto Prefectural University of Medicine Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Sience 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku Kyoto 602-8566 JapanYuji Naito, Kyoto Prefectural University of Medicine Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Sience 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku Kyoto 602-8566 JapanMamoru Inoue, Kyoto Second Red Cross Hospital Department of Internal Medicine Kyoto 6... Inflammation journals http://www.medworm.com/rss/comments.php?id=2188306 Fri, 13 Feb 2009 08:20:40 +0100 2188306 http://www.medworm.com/index.php?rid=2188307&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy18j43295p3h7328%2F In this study, we investigated the involvement of heme oxygenase (HO)-1 in the anti-allergic action of kaempferol against degranulation in rat basophilic leukemia (RBL-2H3) cells. Our results demonstrate upregulation of HO enzymatic activity after short (15 min) exposure to kaempferol, followed by the induction of HO-1 expression in protein. The involvement of HO-1 in the kaempferol-induced inhibition of degranulation was confirmed using tin protoporphyrin IX (SnPP), a HO-1 inhibitor. These findings strongly suggest that kaempferol exerts anti-allergic actions via activation of the HO-1. Content Type Journal ArticleDOI 10.1007/s10753-009-9108-4Authors Etsuko Hirose, Nagoya University School of Health Science Department of Medical Technology 1-1-20 Daikou-minami, Higashi-ku N... Inflammation journals http://www.medworm.com/rss/comments.php?id=2188307 Fri, 13 Feb 2009 08:20:39 +0100 2188307 http://www.medworm.com/index.php?rid=2131606&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj678277022123576%2F Content Type Journal ArticleDOI 10.1007/s10753-009-9104-8Authors Shailendra Kapoor, Schaumburg IL 690195 USA Journal InflammationOnline ISSN 1573-2576Print ISSN 0360-3997 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2131606 Fri, 23 Jan 2009 09:58:19 +0100 2131606 http://www.medworm.com/index.php?rid=2095108&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7625j601015u27j8%2F Abstract  Clara cell 16-kDa (CC16) is an anti-inflammatory protein chiefly produced in the lung epithelium. CC16 has been shown to inhibit the migration of rabbit neutrophils and human monocytes toward the formyl peptide N-formyl-methionine-leucin-phenylalanin (fMLF). Eosinophils migrate towards prostaglandin D2 (PGD2) and CC16 has been shown to bind to PGD2. Therefore we investigated if CC16 could inhibit the migration of human eosinophils and neutrophils towards fMLF and/or PGD2. Migration of eosinophils and neutrophils was assessed in a microplate migration system using specific ligands and receptor antagonists. CC16 inhibited the migration of eosinophils and neutrophils toward fMLF, which is likely to result from the interaction of CC16 with members of the formyl-peptide r... Inflammation journals http://www.medworm.com/rss/comments.php?id=2095108 Fri, 09 Jan 2009 13:32:28 +0100 2095108 http://www.medworm.com/index.php?rid=2056397&cid=s_35973_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F317828u17158123t%2F In conclusion, the venoms from Tityus are stronger inducers of edema than the venom from the Rhopalurus scorpion. The venoms of Tityus species are similar in potency and time-course edema development. PAF is involved in the edema induced only by Tsv. Content Type Journal ArticleDOI 10.1007/s10753-008-9102-2Authors D. N. Severino, Universidade de Mogi das Cruzes (CIIB-UMC) Centro Interdisciplinar de Investigação Bioquímica Sala 1S15, prédio 1, Av. Dr. Cândido Xavier de Almeida Souza, 200 CEP: 08780-911 Mogi das Cruzes São Paulo BrazilR. L. Pereira, Universidade de Mogi das Cruzes (CIIB-UMC) Centro Interdisciplinar de Investigação Bioquímica Sala 1S15, prédio 1, Av. Dr. Cândido Xavier de Almeida Souza, 200 CEP: 08780-911 Mogi das Cruzes São Paulo BrazilI. Knysak, Instituto ... Inflammation journals http://www.medworm.com/rss/comments.php?id=2056397 Fri, 19 Dec 2008 08:23:45 +0100 2056397 http://www.medworm.com/index.php?rid=2032742&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2008%2F00000007%2F00000004%2Fart00009 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2032742 Sat, 13 Dec 2008 08:27:36 +0100 2032742 http://www.medworm.com/index.php?rid=2032741&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2008%2F00000007%2F00000004%2Fart00008 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2032741 Sat, 13 Dec 2008 08:27:36 +0100 2032741 http://www.medworm.com/index.php?rid=2032740&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2008%2F00000007%2F00000004%2Fart00007 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2032740 Sat, 13 Dec 2008 08:27:36 +0100 2032740 http://www.medworm.com/index.php?rid=2032739&cid=s_35973_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2008%2F00000007%2F00000004%2Fart00006 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=2032739 Sat, 13 Dec 2008 08:27:36 +0100 2032739