MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Inflammation' source. Wed, 08 Feb 2012 06:42:53 +0100 http://www.medworm.com/index.php?rid=5643683&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk1k0716lm0131522%2F Abstract  Antimycin A treatment of cells blocks the mitochondrial electron transport chain and leads to elevated ROS generation. In the present study, we investigated the protective effects of magnolol, a hydroxylated biphenyl compound isolated from Magnolia officinalis, on antimycin A-induced toxicity in osteoblastic MC3T3-E1 cells. Osteoblastic MC3T3-E1 cells were pre-incubated with magnolol before treatment with antimycin A. Cell viability and mineralization of osteoblasts were assessed by MTT assay and Alizarin Red staining, respectively. Mitochondrial dysfunction in cells was measured by mitochondrial membrane potential (MMP), complex IV activity, and ATP level. The cellular antioxidant effect of magnolol in osteoblastic MC3T3-E1 cells was assessed by measuring cardioli... Inflammation journals http://www.medworm.com/rss/comments.php?id=5643683 Thu, 26 Jan 2012 16:44:49 +0100 5643683 http://www.medworm.com/index.php?rid=5624501&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm7128503g576w808%2F Abstract  We aimed to evaluate some of the vascular biomarkers in newly diagnosed, colchicine naive familial Mediterranean fever (FMF) patients. Our primary aim was to investigate the effect of regular colchicine treatment on these variables. Twenty-four (12 males [M] and 12 females [F], 33.3 ± 13.4 years) newly diagnosed FMF patients were included in the study. These patients were started on colchicine treatment following the initial assessment and were studied again no earlier than 2 months. Five patients were lost to follow-up, and assessment of the on-treatment patients was performed on the remaining 19 patients (8 M and 11 F, 33.6 ± 11.8 years). There were 19 healthy subjects (11 M and 8 F, 32.2 ± 7.2 years) who served as a control gro... Inflammation journals http://www.medworm.com/rss/comments.php?id=5624501 Thu, 19 Jan 2012 06:56:34 +0100 5624501 http://www.medworm.com/index.php?rid=5603717&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fbx1t0515h5x13436%2F Abstract  The present study was designed to address the relationship between iron homeostasis and bone metabolism. Cultured hFOB 1.19 osteoblasts were incubated with selected concentrations of hepcidin (50, 100, and 200 nmol/L) for 20 h, harvested for extraction of total RNA and proteins, and the expression of ferroportin 1 was analyzed by RT-PCR and western blotting. The results showed the presence of ferroportin 1 expression in cultured hFOB 1.19 cells. Furthermore, the ferroportin 1 had a similar expression pattern in hFOB cells as in hepatocytes and enterocytes and was downregulated by hepcidin. Our data indicate that osteoblasts are target cells for hepcidin, suggest that hepcidin may have many more targets than previously recognized, and support the role of ... Inflammation journals http://www.medworm.com/rss/comments.php?id=5603717 Sat, 14 Jan 2012 06:54:55 +0100 5603717 http://www.medworm.com/index.php?rid=5592729&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv35v0x5w848471h7%2F Abstract  Increased C-reactive protein (CRP) is a predictor of cardiovascular risk, but its influence on outcomes after coronary artery bypass grafting surgery (CABG) is still incompletely studied. We studied the association between preoperative CRP and inhospital death after CABG. Patients with acute or chronic infectious or inflammatory disorders, autoimmune diseases, cancer, and prior cardiac surgery were excluded. Seventy-six patients were studied [27.6% with elevated CRP (>3 mg/l)]. Elevated CRP was more frequently found in patients who died than in those who survived (83.3% vs 17.1%, p = 0.003); mean CRP levels were, respectively, 6.5 ± 3.4 vs 2.4 ± 3.5 mg/l (p = 0.03). The hazard ratio of death was 11.7 for elevated CRP, and the ROC curve... Inflammation journals http://www.medworm.com/rss/comments.php?id=5592729 Mon, 09 Jan 2012 19:40:14 +0100 5592729 http://www.medworm.com/index.php?rid=5571762&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2012%2F00000011%2F00000001%2Fart00008 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=5571762 Sun, 08 Jan 2012 11:21:06 +0100 5571762 http://www.medworm.com/index.php?rid=5571761&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2012%2F00000011%2F00000001%2Fart00007 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=5571761 Sun, 08 Jan 2012 11:21:06 +0100 5571761 http://www.medworm.com/index.php?rid=5571760&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2012%2F00000011%2F00000001%2Fart00006 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=5571760 Sun, 08 Jan 2012 11:21:06 +0100 5571760 http://www.medworm.com/index.php?rid=5571759&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2012%2F00000011%2F00000001%2Fart00005 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=5571759 Sun, 08 Jan 2012 11:21:06 +0100 5571759 http://www.medworm.com/index.php?rid=5571758&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2012%2F00000011%2F00000001%2Fart00004 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=5571758 Sun, 08 Jan 2012 11:21:05 +0100 5571758 http://www.medworm.com/index.php?rid=5571757&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2012%2F00000011%2F00000001%2Fart00003 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=5571757 Sun, 08 Jan 2012 11:21:05 +0100 5571757 http://www.medworm.com/index.php?rid=5571756&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2012%2F00000011%2F00000001%2Fart00002 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=5571756 Sun, 08 Jan 2012 11:21:05 +0100 5571756 http://www.medworm.com/index.php?rid=5568595&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk474630383606141%2F In this study, we investigated the effect of the combination of SF and OMT on acute lung injury using lipopolysaccharide (LPS)-induced acute lung injury (ALI) mouse model. The cell counting and the protein concentration in the bronchoalveolar lavage fluid (BALF) were measured. The animal lung edema degree was evaluated by wet/dry weight (W/D) ratio. The superoxidase dismutase (SOD) activity and myeloperoxidase (MPO) activity was assayed by SOD and MPO kits, respectively. The levels of inflammatory mediators including C-reactive protein (CRP) and tumor necrosis factor-α (TNF-α) were assayed by enzyme-linked immunosorbent assay method. The data showed that treatment with the combination of SF and OMT markedly attenuated inflammatory cell numbers and protein concentration in the BALF ... Inflammation journals http://www.medworm.com/rss/comments.php?id=5568595 Wed, 04 Jan 2012 17:01:49 +0100 5568595 http://www.medworm.com/index.php?rid=5568594&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4204g1v683176645%2F Abstract  We aim to determine the extent of the CD40-CD40L pathway involvement in activated platelet-induced changes in human umbilical endothelial cells (HUVECs). Activated platelets were co-incubated with HUVECs in the presence or absence of CD40LmAb. HUVECs were also directly stimulated with rhCD40L. HUVEC endothelial cyclooxygenase 2 (COX-2) and peroxisome proliferator-activated receptor alpha (PPARα) expression was then assessed. To estimate COX-2 activity, PGE2 concentration was determined. PPARα activity was assessed using a nuclear factor activity kit. Co-incubation with activated platelets increased HUVEC COX-2 and PPARα mRNA expression (P < 0.01). The addition of CD40L mAb significantly attenuated these increases in mRNA and protein (both P < 0.01)... Inflammation journals http://www.medworm.com/rss/comments.php?id=5568594 Wed, 04 Jan 2012 17:01:49 +0100 5568594 http://www.medworm.com/index.php?rid=5568593&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc113722p61h14449%2F In this study, we examined the biological effects of Th17 cytokines IL-17A and IL-17F on CXCL1, CXCL5, and CXCL8 release in LMVECs. Both IL-17 receptor A (IL-17RA) and IL-17RC are expressed on the surface of LMVECs. In contrast to IL-17F, IL-17A significantly upregulated CXCL1 mRNA expression and protein release, whereas both IL-17A and IL-17F did not have the ability to induce CXCL5 and CXCL8 secretion in LMVECs. IL-17A and IL-17F displayed positive regulatory effects on IL-1β-induced CXCL1, CXCL5, and CXCL8 secretion. On the other hand, IL-17A enhanced the upregulating effect of TNF-α on CXCL1, CXCL5, and CXCL8 release, whereas IL-17F had a negative regulatory effect on TNF-α-mediated secretion. Th2 cytokines IL-4 and IL-13 showed an inhibitory effect on IL-1β plus IL-17A-induc... Inflammation journals http://www.medworm.com/rss/comments.php?id=5568593 Wed, 04 Jan 2012 17:01:49 +0100 5568593 http://www.medworm.com/index.php?rid=5568596&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fpl2th82116148354%2F In this study, we investigated the mechanism of FKN mediated upregulation inflammation in severe acute pancreatitis (SAP) rat models. Western blot, reverse transcriptase-polymerase chain reaction, and immunofluorescence demonstrated that FKN and its receptor CX3CR1 were overexpressed in cerulein-stimulated AR42J cells. AG490 and FKN-siRNA inhibited activation of Janus kinase/signal transducers and activators of transcription (Jak/Stat) in cerulein-stimulated AR42J cells. Following exposure AG490 and FKN-siRNA inhibited tumor necrosis factor-alpha expression by enzyme-linked immunosorbent assay and immunohistochemistry in vivo the SAP rat models. These results showed FKN and CX3CR1 were involved inflammatory response in cerulein-stimulated AR42J cells. FKN upregulates inflammation thr... Inflammation journals http://www.medworm.com/rss/comments.php?id=5568596 Tue, 03 Jan 2012 06:44:36 +0100 5568596 http://www.medworm.com/index.php?rid=5568597&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F50082489k6172776%2F We report here that tumor necrosis factor-α (TNF-α) increased IL-6 and IL-8 production, and that these effects were potentiated by VIP at 10 nM in HK-2 cells. However, VIP at 1 and 100 nM did not display this function. Consistent with these observations, we were able to show that VIP at 10 nM upregulated TNF-α-induced phosphorylation of IκB-α, leading to IκB-α degradation and the subsequent nuclear translocation of NF-κB. Furthermore, VIP-enhanced activation of NF-κB transcription activity was demonstrated using a NF-κB reporter construct upon transient transfection into HK-2 cells. These results strongly suggest that VIP synergistically enhances TNF-α-stimulated IL-6 and IL-8 synthesis via activating the NF-κB pathway in HK-2 cells. Content Type Journ... Inflammation journals http://www.medworm.com/rss/comments.php?id=5568597 Fri, 30 Dec 2011 07:10:51 +0100 5568597 http://www.medworm.com/index.php?rid=5556684&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8u263w8rq6446123%2F Abstract  Pulmonary fibrosis is a chronic disease. Urotensin II (U-II) is a new peptide with angiogenic and profibrotic features. Therefore, we aim to evaluate the antagonism of U-II with palosuran in an animal model and plan to measure U-II, endothelin-1 (ET-1), and transforming growth factor-β1 (TGF-β1) and their association with lung fibrosis. Thirty Wistar male rats were used in the study and were divided into three groups: group 1, control; group 2, bleomycin-induced lung fibrosis group; and group 3, bleomycin-induced lung fibrosis with treatment palosuran group. U-II level (nanograms per milliliter) was 2.957 ± 0.159 in group1, 3.188 ± 0.122 in group 2, and 2.970 ± 0.165 in group 3 (p = 0.002). The ET-1 level (picograms per milliliter) was 4.486 ... Inflammation journals http://www.medworm.com/rss/comments.php?id=5556684 Wed, 28 Dec 2011 16:52:58 +0100 5556684 http://www.medworm.com/index.php?rid=5556685&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl215388602421377%2F Abstract  Mast cell has been demonstrated to be involved in the small intestinal ischemia–reperfusion (IIR) injury, however, the precise role of tryptase released from mast cell on acute lung injury(ALI) induced by IIR remains to be elucidated, our study aimed to observe the roles of tryptase on ALI triggered by IIR and its underlying mechanism. Adult SD rats were randomized into sham-operated group, sole IIR group in which rats were subjected to 75 min superior mesenteric artery occlusion followed by 4 h reperfusion, or IIR being respectively treated with cromolyn sodium, protamine, and compound 48/80. The above agents were, respectively, administrated intravenously 5 min before reperfusion. At the end of experiment, lung tissue was obtained for assays for... Inflammation journals http://www.medworm.com/rss/comments.php?id=5556685 Mon, 26 Dec 2011 16:47:01 +0100 5556685 http://www.medworm.com/index.php?rid=5542133&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9218467018551q8u%2F Abstract  Opioids have been used for long time to management of pain, the coadministration of two opioids may induce synergism. The present study was conducted to determine the antinociceptive interaction between the dual mechanism of action of tramadol compared to the main of fentanyl antinociception in the orofacial formalin which represents a model of persistent cutaneous nociception in the region innervated by the trigeminal nerve. The i.p. administration of tramadol and fentanyl induced a dose-dependent antinociception with an ED50 of 2.97 ± 0.32 mg/kg for phase I and 1.79 ± 0.30 mg/kg for phase II and 0.062 ± 0.0040 mg/kg in phase I and 0.041 ± 0.0039 mg/kg in phase II, respectively. The coadministration of fentanyl with tramadol... Inflammation journals http://www.medworm.com/rss/comments.php?id=5542133 Fri, 23 Dec 2011 16:51:59 +0100 5542133 http://www.medworm.com/index.php?rid=5542134&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6370642555237810%2F In conclusion, these findings suggest that cancer-related changes are not exclusive factors contributing to elevated serum sPLA2-IIA levels and emphasize the utility of sPLA2-IIA as a circulating marker of inflammation in patients with BPH and PCa. Content Type Journal ArticlePages 1-6DOI 10.1007/s10753-011-9418-1Authors Mario Menschikowski, Institute of Clinical Chemistry and Laboratory Medicine, Medical Faculty “Carl Gustav Carus”, Technical University of Dresden, Fetscherstrasse 74, 01307 Dresden, GermanyAlbert Hagelgans, Institute of Clinical Chemistry and Laboratory Medicine, Medical Faculty “Carl Gustav Carus”, Technical University of Dresden, Fetscherstrasse 74, 01307 Dresden, GermanySusanne Fuessel, Department of Urology, Medical Faculty “Carl Gustav Carus”, Tec... Inflammation journals http://www.medworm.com/rss/comments.php?id=5542134 Wed, 21 Dec 2011 20:07:47 +0100 5542134 http://www.medworm.com/index.php?rid=5520196&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj646876344341004%2F In this study, we analyzed the expression of HVEM and BTLA in RA synovium by immunohistochemistry, and our results showed that both factors were observed in all four cases of RA samples. At the cellular level, both HVEM and BTLA were found on the cell membrane and in the cytoplasm. Fluorescence dual staining demonstrated that HVEM was chiefly on CD3+ T cells, CD68+ macrophages, and to a lesser extent was found on CD31+ endothelial cells. Similarly, the expression of BTLA was observed on infiltrated CD3+ T cells and CD68+ macrophages. The co-expression of HVEM and BTLA with some members of the B7 family in these sections was also analyzed, and the results showed that HVEM antigen was also found on B7-H3+ capillaries, while it was absent on B7-H1+, B7-DC+, B7-H4+, and Z39Ig+ cells. Inter... Inflammation journals http://www.medworm.com/rss/comments.php?id=5520196 Sat, 17 Dec 2011 06:45:22 +0100 5520196 http://www.medworm.com/index.php?rid=5512140&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg507402702875266%2F This study was conducted to investigate the effect of morphine on CD4-positive T cells differentiation and the transcriptional factors induced by phorbol myristate acetate (PMA) and ionomycin. CD4-positive lymphocytes separated from healthy volunteers were incubated by PMA (25 ng/ml) + ionomycin (1 μg/ml) with or without the presence of morphine, ketamine, or naloxone. Th subsets, supernatant cytokines, and transcriptional factors were detected 4 h later. Th1 and Th2 cells, levels of INF-γ, IL-2, IL-4 and the activities of T-bet and GATA3 were significantly increased after incubation with PMA and ionomycin. However, the number of Th1 cells, Th1/ Th2, the levels of INF-γ and INF-γ/IL-4, and the activities and protein levels of T-bet and GATA3 were decreased afte... Inflammation journals http://www.medworm.com/rss/comments.php?id=5512140 Mon, 12 Dec 2011 17:13:00 +0100 5512140 http://www.medworm.com/index.php?rid=5512142&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp5w688v5wl888037%2F Abstract  The aim of this study is to investigate prospectively specific immune system factors in preterm neonates with late-onset sepsis and infection-free controls. Matched preterm neonates (n = 82) were divided into three groups: suspected infection (n = 25), sepsis (n = 17), and infection-free controls (n = 40). Serial measurements were made of interleukin-6 (IL-6), IL-1β, tumor necrosis factor-α (TNF-α), lymphocyte subsets [CD3+, CD4+, CD8+, natural killer (NK) cells, and B cells], the immunoglobulins (IgG, IgM, and IgA), C-reactive protein (CRP), and the total blood count, before, 2 days after initiation of treatment, and after stopping treatment. The percentages of NK and B cells were higher in the sepsis group, but those of CD3+, CD4+, and CD8+... Inflammation journals http://www.medworm.com/rss/comments.php?id=5512142 Mon, 12 Dec 2011 17:12:59 +0100 5512142 http://www.medworm.com/index.php?rid=5512141&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F055n061l528hg7q8%2F Abstract  Alveolar macrophages (AMs) can initiate lung inflammation by producing pro-inflammatory cytokines and chemokines, but they participate actively in the prevention of inflammation during acute lung injury (ALI). Heme oxygenase-1 (HO-1) is mainly expressed in AMs and has anti-inflammatory properties in ALI, but the anti-inflammatory mechanisms of HO-1 are largely unknown. In this study, AMs were treated with saline, LPS (1 μg/ml), hemin (10 μM), zinc protoporphyrin (ZnPP; 10 μM, 1 h prior to LPS and hemin), SB203580 (10 μM, 1 h prior to LPS and hemin), or their combination up to 24 h. The specific HO-1 inhibitor ZnPP and SB203580 were used to inhibit the effects of HO-1 and the phosphorylated p38 mitogen-activated protein kinase ... Inflammation journals http://www.medworm.com/rss/comments.php?id=5512141 Mon, 12 Dec 2011 17:12:59 +0100 5512141 http://www.medworm.com/index.php?rid=5500953&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd6m9752028n51n48%2F This study aims to research the effect of HSP65 on the expression of adhesion molecules in activated mice heart endothelial cells (MHECs), which were from myocardial tissue of newborn animals. We used different concentrations of LPS as potent inducers to stimulate MHECs, adhesion molecule expression in vitro, including intercellular adhesion molecule-1 (ICAM-1), vascular adhesion molecule-1 (VCAM-1), E-, and P-selectins, then compared the mRNA and protein levels of adhesion molecules expression with or without HSP65 treatment at different levels. The optimal concentration of LPS to induce MHECs adhesion molecule expression is 100 ng/ml; HSP65 treatment significantly reduced the mRNA and protein levels of MHECs’ ICAM-1, VCAM-1, E-, and P-selectins expression (p < 0.05), a... Inflammation journals http://www.medworm.com/rss/comments.php?id=5500953 Thu, 08 Dec 2011 07:20:58 +0100 5500953 http://www.medworm.com/index.php?rid=5482792&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ffmx548nv59270150%2F Abstract  As a late mediator of inflammation, the high-mobility group box 1 protein (HMGB1) plays a key role in the inflammatory responses to tissue injury and infection by inducing and extending the production of proinflammatory cytokines. It has been observed that lower concentration thrombin mediates anti-inflammatory activities. The aim of this study was to investigate whether lower concentration thrombin could modulate HMGB1 expression and could inhibit HMGB1-mediated inflammatory responses in human umbilical vein endothelial cells (HUVECs). Here, results showed that lower concentration thrombin or thrombin receptor agonist peptide inhibits lipopolysaccharide-induced HMGB1 release from HUVECs. And lower concentration thrombin has inhibitory effects not only on the expr... Inflammation journals http://www.medworm.com/rss/comments.php?id=5482792 Fri, 02 Dec 2011 18:09:18 +0100 5482792 http://www.medworm.com/index.php?rid=5473473&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb25r862vuv460t86%2F Abstract  Aberrantly activated macrophages, which overproduce inflammatory mediators, are involved in the pathogenesis of many inflammatory diseases. We analyzed the anti-inflammatory activity of lansoprazole (LPZ), a typical proton pump (P-ATPase) inhibitor, on RAW264.7 murine macrophages. Treatment of lipopolysaccharide (LPS)-stimulated RAW264.7 cells with LPZ inhibited the production of nitric oxide (NO) and prostaglandin E2 (PGE2). Since P-ATPase expression was not observed in RAW264.7 cells, the anti-inflammatory effect of LPZ was independent of ATPase. In contrast, diphenylene iodonium (DPI), an inhibitor of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, decreased NO but not PGE2 levels. LPZ suppressed the LPS-stimulated production by RAW264.7 cells of re... Inflammation journals http://www.medworm.com/rss/comments.php?id=5473473 Thu, 01 Dec 2011 19:22:38 +0100 5473473 http://www.medworm.com/index.php?rid=5465022&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa15uq6002q730720%2F This study suggests that Rho/ROCK pathway plays a role in LA-induced ICAM-1 expression, which is possibly mediated by NF-κB in HAECs. Content Type Journal ArticlePages 1-8DOI 10.1007/s10753-011-9409-2Authors Chang Hee Jung, Department of Internal Medicine, University of Ulsan College of Medicine, Poongnap-dong, Songpa-gu, Seoul 138-736, Republic of KoreaWoo Je Lee, Department of Internal Medicine, University of Ulsan College of Medicine, Poongnap-dong, Songpa-gu, Seoul 138-736, Republic of KoreaJenie Yoonoo Hwang, Department of Internal Medicine, University of Ulsan College of Medicine, Poongnap-dong, Songpa-gu, Seoul 138-736, Republic of KoreaSo Mi Seol, Asan Institute of Life Sciences, University of Ulsan College of Medicine, Seoul, Republic of KoreaYun Mi Kim, Asan Institute of... Inflammation journals http://www.medworm.com/rss/comments.php?id=5465022 Mon, 28 Nov 2011 16:50:48 +0100 5465022 http://www.medworm.com/index.php?rid=5447474&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl00g520u16657161%2F Abstract  The aim of this study was to observe scutellarin parenteral solution’s therapeutic effects and mechanisms in rats with severe acute pancreatitis (SAP). We divided SD rats into four groups randomly: (1) sham-operated group, (2) model control group, (3) scutellarin-treated group, and (4) Salvia miltiorrhiza-treated group. All of those rats in the abovementioned groups are randomly subdivided into 6 and 12 h subgroups, respectively, according to the postoperative time. Rats have been mercifully killed at different time after operation, and then detected their serum amylase, contents of ALT, AST, BUN, and Cr and observed the pathologic changes of multiple organs (pancreas, liver, kidneys, and lungs). We found that the survival rates have no marked differences (P... Inflammation journals http://www.medworm.com/rss/comments.php?id=5447474 Mon, 21 Nov 2011 18:03:37 +0100 5447474 http://www.medworm.com/index.php?rid=5437129&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv4856x85074v4043%2F Abstract  We investigated the anti-inflammatory activities of argirein and rhein on inflammatory edema in rat paw which was caused by complete adjuvant, compared with ibuprofen. We hypothesized that the adjuvant-induced inflammation is attributed to upregulation of activating transcript factor 6 (ATF6; a chaperone for endoplasmic reticulum (ER) stress), p66Shc (an adaptive protein modulating oxidative stress), and NADPH oxidase subunits p22phox and gp91phox in the inflamed tissues. Biomarkers were measured in the rat paw in association with monitoring swellings. The primary inflammatory edema of the injected paw occurred rapidly and sustained over a couple of days, and the secondary inflammation developed 2 weeks later. The inflammatory edema was accompanied by upregul... Inflammation journals http://www.medworm.com/rss/comments.php?id=5437129 Fri, 18 Nov 2011 07:00:59 +0100 5437129 http://www.medworm.com/index.php?rid=5427833&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn3304nh417183u17%2F Abstract  C-reactive protein (CRP) is a much used biomarker for respiratory tract infection; however, the influence of airway infection on the CRP level in the general population has not been well described. The study aimed to evaluate the impact of recent symptoms of airway infection on the CRP level and how the predictive power of other known CRP predictors is influenced by taking respiratory symptoms into account. A total of 6,325 participants, aged 38–87 years, in the Tromsø Study, a repeated population-based survey, were examined with questionnaires, measurements of height and weight, spirometry, and high-sensitivity CRP analyses. The mean CRP value was 2.86 mg/L, and the geometric mean was 1.51 mg/L. Geometric means above 2.0 mg/L were found in t... Inflammation journals http://www.medworm.com/rss/comments.php?id=5427833 Wed, 16 Nov 2011 16:47:29 +0100 5427833 http://www.medworm.com/index.php?rid=5417232&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F11517r127865102u%2F Abstract  Praeruptorin C, D, and E (PC, PD, and PE) are three pyranocoumarins isolated from the dried root of Peucedanum praeruptorum Dunn of Umbelliferae. In the present study, we investigated the anti-inflammatory effect of these compounds in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. Pyranocoumarins significantly inhibited LPS-induced production of nitric oxide, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α). The mRNA and protein expressions of inducible nitric oxide synthase, IL-6, and TNF-α were also suppressed by these compounds. Both PD and PE exhibited greater anti-inflammatory activities than PC. Further study showed that pyranocoumarins suppressed the cytoplasmic loss of inhibitor κB-α protein and inhibited the translocation of N... Inflammation journals http://www.medworm.com/rss/comments.php?id=5417232 Mon, 14 Nov 2011 16:57:02 +0100 5417232 http://www.medworm.com/index.php?rid=5417233&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F803264102250t148%2F In conclusion, the IPEC-J2 cell line on membrane insert was introduced as a fast and reliable investigation tool for oxidative stimuli-triggered intestinal inflammation and in the future as a screening method for antioxidant and probiotic candidates. Content Type Journal ArticlePages 1-11DOI 10.1007/s10753-011-9403-8Authors Erzsebet Paszti-Gere, Department of Pharmacology and Toxicology, Faculty of Veterinary Sciences, Szent István University, Budapest, István u. 2, 1078 HungaryEdina Csibrik-Nemeth, Department of Pharmacology and Toxicology, Faculty of Veterinary Sciences, Szent István University, Budapest, István u. 2, 1078 HungaryKrisztina Szeker, Department of Pharmacology and Toxicology, Faculty of Veterinary Sciences, Szent István University, Budapest, István u. 2, 1078... Inflammation journals http://www.medworm.com/rss/comments.php?id=5417233 Mon, 14 Nov 2011 16:57:01 +0100 5417233 http://www.medworm.com/index.php?rid=5404661&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr74w08n121613562%2F Conclusion C.S.3 may provide clinical applications for asthma in the future. Content Type Journal ArticlePages 1-9DOI 10.1007/s10753-011-9402-9Authors Ya-Ling Chiou, Department of Nutrition & Institute of Biomedical Nutrition, Hung Kuang University, 34 Chung-Chie Rd, Sha Lu, Taichung, 443 Taiwan, Republic of ChinaChing-Yuang Lin, Clinical Immunological Center and Division of Pediatric Nephrology, China Medical University Hospital, 34 Chung-Chie Rd, Sha Lu, Taichung, 443 Taiwan, Republic of China Journal InflammationOnline ISSN 1573-2576Print ISSN 0360-3997 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=5404661 Wed, 09 Nov 2011 07:03:46 +0100 5404661 http://www.medworm.com/index.php?rid=5404662&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft514075n630r70t7%2F In conclusion, hsCRP and NO levels predict the incidence of ischemic stroke and hsCRP is an independent prognostic factor of poor outcome at 3 months. Content Type Journal ArticlePages 1-7DOI 10.1007/s10753-011-9401-xAuthors K. Rajeshwar, Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad, 500016 IndiaSubhash Kaul, Nizam’s Institute of Medical Sciences, Punjagutta, Hyderabad, 500082 IndiaAmal Al-Hazzani, Department of Botany and Microbiology, King Saud University, Riyadh, Saudi ArabiaM. Sai Babu, Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad, 500016 IndiaN. Balakrishna, National Institute of Nutrition, Tarnaka, Hyderabad, IndiaVandana Sharma, Institute of Genetics and Hospital f... Inflammation journals http://www.medworm.com/rss/comments.php?id=5404662 Tue, 08 Nov 2011 19:13:45 +0100 5404662 http://www.medworm.com/index.php?rid=5382938&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000006%2Fart00008 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=5382938 Mon, 07 Nov 2011 23:41:24 +0100 5382938 http://www.medworm.com/index.php?rid=5382937&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000006%2Fart00007 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=5382937 Mon, 07 Nov 2011 23:41:24 +0100 5382937 http://www.medworm.com/index.php?rid=5382936&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000006%2Fart00006 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=5382936 Mon, 07 Nov 2011 23:41:24 +0100 5382936 http://www.medworm.com/index.php?rid=5382935&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000006%2Fart00005 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=5382935 Mon, 07 Nov 2011 23:41:24 +0100 5382935 http://www.medworm.com/index.php?rid=5382934&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000006%2Fart00004 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=5382934 Mon, 07 Nov 2011 23:41:24 +0100 5382934 http://www.medworm.com/index.php?rid=5382933&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000006%2Fart00003 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=5382933 Mon, 07 Nov 2011 23:41:24 +0100 5382933 http://www.medworm.com/index.php?rid=5382932&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000006%2Fart00002 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=5382932 Mon, 07 Nov 2011 23:41:24 +0100 5382932 http://www.medworm.com/index.php?rid=5382931&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000006%2Fart00001 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=5382931 Sat, 05 Nov 2011 02:19:51 +0100 5382931 http://www.medworm.com/index.php?rid=5374814&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F77480h8244770732%2F Abstract  In view of the folklore use of green leaves to treat inflammation, the anti-inflammatory property of chlorophylls and their degradation products were studied. Chlorophyll a and pheophytin a (magnesium-free chlorophyll a) from fresh leaves showed potent anti-inflammatory activity against carrageenan-induced paw edema in mice and formalin-induced paw edema in rats. Chlorophyll a inhibited bacterial lipopolysaccharide-induced TNF-α (a pro-inflammatory cytokine) gene expression in HEK293 cells, but it did not influence the expression of inducible nitric acid synthase and cyclooxygenase-2 genes. Chlorophyll b only marginally inhibited both inflammation and TNF-α gene expression. But both chlorophyll a and chlorophyll b showed the same level of marginal inhibition on ... Inflammation journals http://www.medworm.com/rss/comments.php?id=5374814 Sat, 29 Oct 2011 05:49:56 +0100 5374814 http://www.medworm.com/index.php?rid=5374813&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff7h518171u234u77%2F In this study, 57 obese adolescents with and without metabolic syndrome underwent 1 year of weight loss therapy. At baseline, the metabolic syndrome (MS) patients presented higher values of PAI-1 than the non-metabolic syndrome patients (n-MS). After therapy, significant improvements in anthropometrics and biochemical, inflammatory, and neuroendocrine variables were observed in both groups. However, the n-MS group presented better results than the MS group. Indeed, we found positive correlations in both groups between PAI-1 and neuropeptide Y (NPY) and between PAI-1 and NPY/AgRP. Inflammatory biomarkers may thus play a role in energy balance. The clinical trial registration number is NCT01358773. Content Type Journal ArticlePages 1-8DOI 10.1007/s10753-011-9397-2Authors Fl... Inflammation journals http://www.medworm.com/rss/comments.php?id=5374813 Sat, 29 Oct 2011 05:49:56 +0100 5374813 http://www.medworm.com/index.php?rid=5343390&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu64764008756u711%2F Abstract  Although there is ample evidence that Kawasaki disease (KD) is associated with vascular inflammation, few studies have addressed the influence of oxidative stress. The goal of this study was to determine whether oxidative stress contributes to inflammation during KD, and also whether corticosteroid therapy can reduce oxidative stress. Serum reduced glutathione (sGSH) and serum thioredoxin (sTRX) were measured during KD to evaluate the phase-dependent change in the redox state in KD. Additionally, the efficacy of the therapies to reduce oxidative stress was assessed. The sGSH level significantly decreased post-intravenous immunoglobulin (IVIG). The sGSH level significantly increased during the convalescent phase. The sTRX level was significantly lower during the co... Inflammation journals http://www.medworm.com/rss/comments.php?id=5343390 Wed, 19 Oct 2011 15:46:24 +0100 5343390 http://www.medworm.com/index.php?rid=5343391&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh1t47316m103r3x2%2F Abstract  Forty-two patients with systemic lupus erythematosus (SLE), including 26 patients with renal damage and 16 without, and 20 healthy controls were included in the study. The isolated peripheral blood mononuclear cells (PBMCs) were treated with a p38 inhibitor (SB203580) or anti-tumor necrosis factor-like weak inducer of apoptosis (TWEAK) mAb, with or without phytohemagglutinin/phorbol myristate acetate (PHA/PMA) stimulation. Western blot experiments were used to evaluate the protein expression of TWEAK and p38 MAPK in PBMCs .Next, the contents of interleukin-10 (IL-10) and monocyte chemoattractant protein-1 (MCP-1) in the supernatant were measured by ELISA. The results showed that expression of TWEAK protein in PBMCs from lupus nephritis patients was significantly h... Inflammation journals http://www.medworm.com/rss/comments.php?id=5343391 Wed, 19 Oct 2011 05:57:21 +0100 5343391 http://www.medworm.com/index.php?rid=5321258&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fvx3v415758515635%2F Abstract  Methicillin-resistant Staphylococcus aureus (MRSA) with exogenous cassette DNA containing the methicillin-resistant gene mecA (SCCmec) poses a problem as a drug-resistant bacterium responsible for hospital- and community-acquired infections. The frequency of MRSA detection has recently been increasing rapidly in Japan, and SCCmec has also been classified more diversely into types I–V. A rapid test is essential for early diagnosis and treatment of MRSA infections, but detection by conventional methods requires at least two days. The newly developed multiplex PCR lateral flow method allows specific amplification of femA to detect S. aureus, mecA to detect SCCmec, and kdpC to detect SCCmec type II; moreover, PCR products can be evaluated visually in about 3 h. In... Inflammation journals http://www.medworm.com/rss/comments.php?id=5321258 Wed, 12 Oct 2011 16:33:29 +0100 5321258 http://www.medworm.com/index.php?rid=5301660&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fwv1l50h6u65h74g1%2F Abstract  The purpose of the present study was to investigate the antibacterial and anti-inflammatory activity of Angelica sinensis extract (AE), Sophora flavescens extract (SE), and herb pair A. sinensis and S. flavescens extract (HPE). Endotoxin-induced uveitis (EIU) was induced in rats by a footpad injection of lipopolysaccharide. The anti-inflammatory potential of AE, SE, and HPE in the regulation of nuclear factor kappa B (NF-κB), maleic dialdehyde (MDA), polymorphonuclear cells (PMN), interleukin-1β (IL-1β), inducible nitric oxide synthase (iNOS) and tumor necrosis factor-α (TNF-α), adhesion molecule (ICAM-1), and cyclooxygenase-2 (COX-2) was determined by ELISA and immunohistochemistry. HPE showed strong antibacterial activity at all tested concentrations (1.25, 2... Inflammation journals http://www.medworm.com/rss/comments.php?id=5301660 Thu, 06 Oct 2011 05:50:28 +0100 5301660 http://www.medworm.com/index.php?rid=5301659&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Few221405778m1202%2F The objective of this study was to fill this gap. We did this by investigating the barrier protective activities of phloroglucinol on lipopolysaccharide (LPS)-induced barrier disruption in human endothelial cells measured by cellular permeability, monocytes adhesion, and migration toward human endothelial cells. The results showed that phloroglucinol inhibited LPS-induced barrier hyperpermeability, monocyte adhesion, and migration. These inhibitory effects were significantly correlated with the inhibitory functions of phloroglucinol on LPS-induced cell adhesion molecules. Furthermore, LPS-induced nuclear factor-κB (NF-κB) and tumor necrosis factor-κB (TNF-κB) release from human umbilical vein endothelial cells (HUVECs) was inhibited by phloroglucinol. Given these results, phlorog... Inflammation journals http://www.medworm.com/rss/comments.php?id=5301659 Thu, 06 Oct 2011 05:50:28 +0100 5301659 http://www.medworm.com/index.php?rid=5301661&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe65126744p42w681%2F Abstract  Ulcerative colitis (UC) and Crohn’s disease (CD) are two related yet different forms of chronic intestinal inflammation. We investigated the genes regulated by NKX2-3 in B cells from a UC patient by cDNA microarray and compared the results to those genes regulated by NKX2-3 in B cells from a CD patient. Genes regulated by NKX2-3 in B cells from UC were mainly involved in cell growth, inflammation, and immune response. Among the genes regulated by NKX2-3 in both UC and CD, expression of 145 genes was similarly altered and 34 genes was differentially affected by NKX2-3 knockdown. EGR1 was up-regulated in NKX2-3 knockdown B cells from UC while down-regulated in NKX2-3 knockdown B cells from CD. mRNA expressions of NKX2-3 and EGR1 were increased in diseased intestinal ti... Inflammation journals http://www.medworm.com/rss/comments.php?id=5301661 Tue, 04 Oct 2011 05:52:03 +0100 5301661 http://www.medworm.com/index.php?rid=5301662&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fmurvk63304158301%2F This study was aimed to explore this polymorphism in parallel with SDF-1 serum levels in type 2 diabetic patients. In this assessment, peripheral blood samples were collected from 200 type 2 diabetic patients and 200 healthy controls. DNA was extracted, and a PCR-RFLP screening was applied to examine the SDF-1β 3′A polymorphism. We also applied the ELISA technique to measure serum levels of SDF-1. Our results showed that there were no significant correlations between SDF-1β 3′Α polymorphism in type 2 diabetic patients when compared to controls. However, our results showed that the serum levels of SDF-1 were significantly increased in the patients when compared to controls. Based on the results of this study, we concluded that SDF-1β 3′Α polymorphism does not play a role i... Inflammation journals http://www.medworm.com/rss/comments.php?id=5301662 Tue, 04 Oct 2011 05:52:02 +0100 5301662 http://www.medworm.com/index.php?rid=5281252&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu5516224u6501835%2F Abstract  Wear particle-induced aseptic loosening has been recognized as a harmful inflammatory process that jeopardizes the longevity of total joint replacement. The proteasome controls the activation of NF-κB and subsequent inflammatory mediators, such as TNF-α and IL-1β; thus, we investigated whether proteasome inhibition can ameliorate wear particle-induced inflammation in a murine model. A total of 48 BALB/C mice were divided into four groups. Titanium (Ti) particles were injected into the established air pouches of all mice (except negative controls) to provoke inflammation, and then 0.1 or 0.5 mg/kg of Bortezomib (Bzb, a proteasome inhibitor) was administered to ameliorate the inflammation response, while air pouches without Bzb administration were used as lo... Inflammation journals http://www.medworm.com/rss/comments.php?id=5281252 Sat, 01 Oct 2011 06:46:11 +0100 5281252 http://www.medworm.com/index.php?rid=5257137&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj313640p15324113%2F Abstract  The present study evaluates the anti-inflammatory and antigranuloma activity of CLHE in experimental models, viz. carrageenan-induced paw edema, subcutaneous cotton pellet implantation-induced granuloma formation, and complete Freund's adjuvant-induced stimulation of peritoneal macrophages in rats. Serum TNF-alpha, IL-6, and IL-1 beta levels were estimated as markers for global effects of inflammation. TNF-R1 protein expression was estimated in stimulated peritoneal macrophages. There was a significant reduction (P < 0.05) of paw edema in the CLHE-treated groups as compared to control. In the cotton pellet-induced granuloma model, there was a significant (P < 0.05) reduction in the dry granuloma weight and serum TNF-alpha, IL-6, and IL-1beta levels in ... Inflammation journals http://www.medworm.com/rss/comments.php?id=5257137 Thu, 22 Sep 2011 05:52:07 +0100 5257137 http://www.medworm.com/index.php?rid=5257138&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe7u1v24g11641661%2F Abstract  Diabetes predisposes to aortic stenosis (AS). We aimed to investigate if diabetes affects the expression of selected coagulation proteins and inflammatory markers in AS valves. Twenty patients with severe AS and concomitant type 2 diabetes mellitus (DM) and 40 well-matched patients without DM scheduled for valve replacement were recruited. Valvular tissue factor (TF), TF pathway inhibitor (TFPI), prothrombin, C-reactive protein (CRP) expression were evaluated by immunostaining and TF, prothrombin, and CRP transcripts were analyzed by real-time PCR. DM patients had elevated plasma CRP (9.2 [0.74–51.9] mg/l vs. 4.7 [0.59–23.14] mg/l, p = 0.009) and TF (293.06 [192.32–386.12] pg/ml vs. 140 [104.17–177.76] pg/ml, p = 0.003) compared to non-DM patients. I... Inflammation journals http://www.medworm.com/rss/comments.php?id=5257138 Wed, 21 Sep 2011 05:55:18 +0100 5257138 http://www.medworm.com/index.php?rid=5257139&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F81655l88721n1073%2F Abstract  Interleukin (IL)-8 and neutrophil inflammation play a vital role in the pathogenesis of chronic inflammatory airway diseases. A disintegrin and metalloproteinase 17 (ADAM17) cleaves ectodomains of various transmembrane proteins and is an important regulator of almost every cellular event. The aim of this work was to investigate the roles of epidermal growth factor receptor (EGFR) signaling and ADAM17 in IL-8 expression induced by lipopolysaccharide (LPS) in A549 lung epithelial cells. In the present study, we found that transforming growth factor-α (TGF-α)-neutralizing Ab, EGFR-neutralizing Ab, and AG1478 significantly inhibited the phosphorylation of EGFR and IL-8 production induced by LPS. Lentivirus-mediated ADAM-17 RNA interference markedly inhibited ADAM-17... Inflammation journals http://www.medworm.com/rss/comments.php?id=5257139 Tue, 20 Sep 2011 05:49:59 +0100 5257139 http://www.medworm.com/index.php?rid=5257140&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff783822k7478j572%2F Abstract  The present study aimed to determine whether curcumin isolated from the rhizome of Curcuma longa Linn could inhibit di-(2-ethylhexyl) phthalate (DEHP)-induced allergic inflammatory responses in human umbilical vein endothelial cells (HUVECs). We found that DEHP dose-dependently elevated adhesion molecule-1 (ICAM-1) protein level within 15–30 min, which was independent of de novo protein synthesis. And a late-phase induction of ICAM-1 was observed within 8 h treatment of DEHP via de novo protein synthesis through transcription and translation. DEHP also increased the expression of interleukin (IL)-8 in a time- and dose-dependent manner. Pretreatment with curcumin dose-dependently decreased DEHP-induced expression of ICAM-1 and IL-8 as well as phosphorylat... Inflammation journals http://www.medworm.com/rss/comments.php?id=5257140 Tue, 20 Sep 2011 05:49:57 +0100 5257140 http://www.medworm.com/index.php?rid=5246026&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft4372h4201q71l26%2F This study aims to determine whether levosimendan combined with arginine vasopressin infusion supplemented with norepinephrine can improve hemodynamics and pulmonary dysfunction. The study was tested in a fecal peritonitis-induced septic shock model, we observed that levosimendan combined with arginine vasopressin supplemented with norepinephrine therapy resulted in lower mean pulmonary artery pressure, lactate concentrations, arterial total nitrate/nitrite, and high-mobility group box 1 levels; decreased lung wet/dry ratio, and pulmonary levels of interleukin-6, total histological scores, and improved pulmonary gas exchange when compared with norepinephrine group. Levosimendan combined with arginine vasopressin supplemented with norepinephrine infusion shows potential benefit in sep... Inflammation journals http://www.medworm.com/rss/comments.php?id=5246026 Mon, 19 Sep 2011 15:40:45 +0100 5246026 http://www.medworm.com/index.php?rid=5233136&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb855j3q5174n1h17%2F Abstract  Endoplasmic reticulum stress (ER stress) in intestinal epithelial cells (IECs) plays an important role in the pathogenesis and perpetuation of inflammatory bowel disease (IBD). The aim of this study is to explore the potential of berberine (BBR) in regulating pro-inflammatory cytokine-induced ER stress and apoptosis in IECs. ER stress in cultured Caco-2 cells was induced by IFN-γ/TNF-α and tunicamycin, respectively. The experimental groups were pretreated with BBR. Cell viability was determined by MTT assay. In vitro apoptosis was examined by flow cytometry using annexin V-FITC labeling. The molecular markers of ER stress, including GRP-78, p-JNK, caspase-12, and cleaved caspase-3 were analyzed by Western blot. Xbp-1 mRNA splicing was detected by RT-PCR. Pretreat... Inflammation journals http://www.medworm.com/rss/comments.php?id=5233136 Thu, 15 Sep 2011 15:46:45 +0100 5233136 http://www.medworm.com/index.php?rid=5233137&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr786l5666780p210%2F Abstract  The aim of this study was to investigate the relationship between the adiponectin levels and various characteristics of the metabolic syndrome (MS) in a sample of the Tunisian population. Three hundred and fifty-four individuals were included in this study. Body mass index, blood pressure, HDL-cholesterol, triglycerides, glucose, insulin, and adiponectin concentrations were measured. Insulin resistance was assessed by homeostasis model assessment of insulin resistance (HOMA-IR). MS was identified with the NCEP-ATP III criteria. Subjects with MS showed significantly lower adiponectin levels compared to those without MS. For both genders, the prevalence and the number of MS components increased significantly as the adiponectin concentrations decreased. Subjects with... Inflammation journals http://www.medworm.com/rss/comments.php?id=5233137 Mon, 12 Sep 2011 15:53:57 +0100 5233137 http://www.medworm.com/index.php?rid=5217524&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm46764m2177h3016%2F In this study, we aimed to find polymorphisms of this region that may be associated to type 2 diabetic (T2D) patients with and without nephropathy. In this study, peripheral blood samples were collected from 100 T2D patients without nephropathy, 100 T2D patients with nephropathy, and 100 healthy controls. DNA was extracted, and a polymerase chain reaction-restriction fragment length polymorphism technique was performed to examine the polymorphisms within the −592 region of the IL-10 gene. Our results showed a significant difference between the genotypes and alleles of the −592 region of IL-10 in nephropathic and non-nephropathic patients in comparison to the healthy controls. The differences between the two patient groups in relation to genotypes and alleles were not significant.... Inflammation journals http://www.medworm.com/rss/comments.php?id=5217524 Sat, 10 Sep 2011 06:02:47 +0100 5217524 http://www.medworm.com/index.php?rid=5217525&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm814t43u6522k163%2F In this study, the polymorphism at position −592 of the IL-10 promoter of 57 OBI cases was compared and correlated to that of 100 healthy controls by PCR-RFLP techniques. Our results showed that patient and control groups had significant differences regarding genotypes and alleles of the −592 polymorphism in the IL-10 gene. Based on our results, it can be concluded that the −592 polymorphism within the promoter of the IL-10 gene is associated with OBI. Content Type Journal ArticlePages 1-4DOI 10.1007/s10753-011-9381-xAuthors Behzad Nasiri Ahmadabadi, Molecular-Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IranGholamhossein Hassanshahi, Molecular-Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IranMohammad Kazem... Inflammation journals http://www.medworm.com/rss/comments.php?id=5217525 Thu, 08 Sep 2011 05:55:17 +0100 5217525 http://www.medworm.com/index.php?rid=5203898&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv73q104425p4033v%2F In this study, IL-33 was increased through amyloid-beta1–40 (Aβ1–40) stimulation and regulated inflammatory cytokines including IL-6, IL-8, IL-1β, and TNF-α secretion using different signaling pathways in retinal pigment epithelium (RPE) cells. Furthermore, ST2L, the important component of the IL-33 receptor, was significantly increased following recombinant human IL-33 stimulation in RPE cells. These findings suggest that IL-33-mediated inflammatory responses in RPE cells are involved in the pathogenesis of AMD. Greater understanding of the inflammatory effect of IL-33 and its role in RPE cells should aid the development of future clinical therapeutics and enable novel pharmacological approaches towards the prevention of AMD. Content Type Journal ArticlePages 1-9DOI 10.10... Inflammation journals http://www.medworm.com/rss/comments.php?id=5203898 Tue, 06 Sep 2011 15:51:17 +0100 5203898 http://www.medworm.com/index.php?rid=5203899&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4r71p70374g66603%2F Abstract  Pleurisy is an inflammation of the pleural layers that surround the lungs. Despite much research into inflammatory diseases, no drugs with favorable safety profiles are available yet for their treatment. Corn silk has been used in many parts of the world for the treatment of edema, cystitis, gout, kidney stones nephritis, and prostitutes. However, no scientific reports on the anti-inflammatory effects of corn silk were so far available. To test the anti-inflammatory efficacy of corn silk extract (CSEX) in a rat model of carrageenin (Cg)-induced pleurisy, exudate formation, and cellular infiltration, tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β), vascular endothelial growth factor alpha (VEGF-α), interleukin-17 (IL-17), C3 and C4 complement pro... Inflammation journals http://www.medworm.com/rss/comments.php?id=5203899 Tue, 06 Sep 2011 15:51:15 +0100 5203899 http://www.medworm.com/index.php?rid=5194726&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4124073752763263%2F In this study, western blot analysis and quantitative real-time reverse transcription polymerase chain reaction were used to test samples obtained from isolated spontaneously hypertensive rat hearts and Wistar-Kyoto rat hearts subjected to global normothermic ischemia and from neonatal Wistar rat cardiac myocytes undergoing hypoxia. Ischemia did not increase the expression of S100A8 and S100A9 proteins and mRNA in the myocardium either from the spontaneously hypertensive rat hearts or the Wistar-Kyoto rat hearts. In addition, the levels of S100A8 and S100A9 proteins were unchanged in the neonatal rat cardiac myocytes undergoing hypoxia. However, both ischemia and hypoxia activated NF-kappaB in ischemic myocardium and in hypoxic cardiac cells in a time-dependent manner. The results su... Inflammation journals http://www.medworm.com/rss/comments.php?id=5194726 Fri, 02 Sep 2011 05:52:12 +0100 5194726 http://www.medworm.com/index.php?rid=5194727&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn554835032014464%2F This study was conducted to estimate the value of bronchoalveolar lavage fluid (BALF) total cell count (TCC) in the diagnosis of ILD. We analyzed 237 BAL samples from patients with ILD: sarcoidosis (SA), idiopathic pulmonary fibrosis (IPF), cryptogenic organizing pneumonia (COP), hypersensitivity pneumonitis (HP), chronic eosinophilic pneumonia (CEP), and smoking-related ILD (sr-ILD). The control group consisted of 30 healthy volunteers. The statistical analysis revealed significant differences in the BALF TCC between healthy controls and patients with SA, IPF, HP, COP, sr-ILD, and eosinophilic disorders (mean values 6.9 vs. 14.5, 22.5, 22.8, 20.7, 64.5, and 27.3 × 106, respectively). Logistic regression revealed a significant relation between the TCC and ILD diagnosis. We conclu... Inflammation journals http://www.medworm.com/rss/comments.php?id=5194727 Thu, 01 Sep 2011 06:15:28 +0100 5194727 http://www.medworm.com/index.php?rid=5194728&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe58t305156p45440%2F This study aimed to evaluate the preventive and therapeutic efficacies of bortezomib on a bleomycin (BLM)-induced scleroderma model. Dermal fibrosis was induced in Balb/c mice by subcutaneous BLM (100 μg/day) injections. Bortezomib (1.6 mg/kg twice/week) was applied intraperitoneally to BLM-injected mice during the first 3 weeks for preventive interventions and in the second 3 weeks for therapeutic interventions. IL-4 and TGF-β1 serum levels, dermal thicknesses, dermal inflammatory cell counts, and α-SMA-positive fibroblastic cell counts were determined, and type-I collagen, NF-κBp65, I-κBα, and JNK1 expressions were assessed. BLM applications increased serum IL-4 level, dermal inflammatory cell counts, α-SMA-positive cell counts, expression of type-I colla... Inflammation journals http://www.medworm.com/rss/comments.php?id=5194728 Thu, 01 Sep 2011 06:15:27 +0100 5194728 http://www.medworm.com/index.php?rid=5175313&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000005%2Fart00013 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=5175313 Tue, 30 Aug 2011 12:13:17 +0100 5175313 http://www.medworm.com/index.php?rid=5175312&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000005%2Fart00012 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=5175312 Tue, 30 Aug 2011 12:13:17 +0100 5175312 http://www.medworm.com/index.php?rid=5175311&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000005%2Fart00011 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=5175311 Tue, 30 Aug 2011 12:13:17 +0100 5175311 http://www.medworm.com/index.php?rid=5175310&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000005%2Fart00010 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=5175310 Tue, 30 Aug 2011 12:13:17 +0100 5175310 http://www.medworm.com/index.php?rid=5175309&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000005%2Fart00009 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=5175309 Tue, 30 Aug 2011 12:13:17 +0100 5175309 http://www.medworm.com/index.php?rid=5175308&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000005%2Fart00008 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=5175308 Tue, 30 Aug 2011 12:13:17 +0100 5175308 http://www.medworm.com/index.php?rid=5175307&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000005%2Fart00007 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=5175307 Tue, 30 Aug 2011 12:13:17 +0100 5175307 http://www.medworm.com/index.php?rid=5175306&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000005%2Fart00006 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=5175306 Tue, 30 Aug 2011 12:13:17 +0100 5175306 http://www.medworm.com/index.php?rid=5175305&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000005%2Fart00005 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=5175305 Tue, 30 Aug 2011 12:13:17 +0100 5175305 http://www.medworm.com/index.php?rid=5175304&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000005%2Fart00004 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=5175304 Tue, 30 Aug 2011 12:13:17 +0100 5175304 http://www.medworm.com/index.php?rid=5175303&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000005%2Fart00003 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=5175303 Tue, 30 Aug 2011 12:13:17 +0100 5175303 http://www.medworm.com/index.php?rid=5175302&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000005%2Fart00002 This article is currently available as a free download on ingentaconnect (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=5175302 Tue, 30 Aug 2011 12:13:17 +0100 5175302 http://www.medworm.com/index.php?rid=5175301&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000005%2Fart00001 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=5175301 Tue, 30 Aug 2011 02:15:06 +0100 5175301 http://www.medworm.com/index.php?rid=5173827&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fhh608w00gqr531x8%2F Content Type Journal ArticleCategory ErratumPages 1-1DOI 10.1007/s10753-011-9377-6Authors Takahiro Kataoka, Graduate School of Health Sciences, Okayama University, 5-1 Shikata-cho 2-chome, Kita-ku, Okayama-shi, Okayama 700-8558, JapanJunichi Teraoka, Graduate School of Health Sciences, Okayama University, 5-1 Shikata-cho 2-chome, Kita-ku, Okayama-shi, Okayama 700-8558, JapanAkihiro Sakoda, Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency, 1550 Kagamino-cho, Tomata-gun, Okayama 708-0698, JapanYuichi Nishiyama, Graduate School of Health Sciences, Okayama University, 5-1 Shikata-cho 2-chome, Kita-ku, Okayama-shi, Okayama 700-8558, JapanKeiko Yamato, Graduate School of Health Sciences, Okayama University, 5-1 Shikata-cho 2-chome, Kita-ku, Okayama-shi, Okayama 700-85... Inflammation journals http://www.medworm.com/rss/comments.php?id=5173827 Fri, 26 Aug 2011 16:18:03 +0100 5173827 http://www.medworm.com/index.php?rid=5155348&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk6rr562146520821%2F In this study, we investigated the expression of Toll-like receptor 4 (TLR4) and CD14+CD16+ monocytes in patients with T2DM and DN patients with uremia and TLR4 response to lipopolysaccharide (LPS), and to further explore the potential effects of inflammatory immune response in T2DM and DN uremia. Thirty DN patients with uremia, 28 T2DM patients, and 20 healthy volunteers were enrolled for the determination of CD14+CD16+ fluorescence intensity and TLR4 expression on monocytes by using peripheral blood flow cytometry. Serum C-reactive protein (CRP) level was determined by using the immunoturbidimetry. Peripheral blood mononuclear cells (PBMCs) were isolated and stimulated with LPS for 24 h. monocytes were collected to detect NF-κB p65 and phosphorylated STAT5(p-STAT5) expressions... Inflammation journals http://www.medworm.com/rss/comments.php?id=5155348 Wed, 17 Aug 2011 06:05:53 +0100 5155348 http://www.medworm.com/index.php?rid=5155349&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F351n796rppx8k571%2F Abstract  Extracellular matrix-degrading protease, matrix metalloproteinase-9 (MMP-9), is known to be involved in vascular smooth muscle cell (SMC)’s aberrant proliferation and movement in atherosclerotic lesions. During screening of the MMP-9-inhibitory compounds from marine animal resources, we have found that the ethyl acetate extract from Cliona celata (ECC) effectively inhibits the SMC-derived MMP-9 enzyme activity and gene expression. In addition, the ECC effectively repressed the migration potential of the tumor necrosis factor-α (TNF-α)-stimulated human aortic smooth muscle cell (HASMC). As assessed by Western blot analysis, the produced MMP-9 protein levels in the TNF-α-induced HASMC were significantly decreased by the concomitant treatment of ECC at the 50- to... Inflammation journals http://www.medworm.com/rss/comments.php?id=5155349 Tue, 16 Aug 2011 06:16:16 +0100 5155349 http://www.medworm.com/index.php?rid=5137593&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv2x3717862432623%2F Abstract  The present study was carried out to investigate the anti-inflammatory effect of the hexane extract of the leaves from Clusia nemorosa G. Mey, called HECn, using carrageenan-induced mice pleurisy and cotton pellet-induced mice granuloma. Additionally, the ability of HECn to affect both neutrophil migration as viability was investigated by use of the Boyden chamber assay and flow cytometry, respectively. The HECn significantly inhibited exudation, total leukocytes and neutrophils influx, as well as TNFα levels in carrageenan-induced pleurisy. However, the extract not suppressed the granulomatous tissue formation in the cotton pellet-induced granuloma test. Experiments performed in vitro revealed that HECn on human neutrophils inhibited a dose-dependent manner the CX... Inflammation journals http://www.medworm.com/rss/comments.php?id=5137593 Sat, 13 Aug 2011 06:15:49 +0100 5137593 http://www.medworm.com/index.php?rid=5129816&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk8u661v5588pu171%2F Abstract  Decreased levels of class II major histocompatibility complex (MHC) expression and impaired formation of immunological synapse by dendritic cells (DCs) of HLA-B27 transgenic rats have been recently demonstrated. The resulting dysfunction of DCs may be implicated in the pathogenesis of the HLA-B27-related disease in transgenic animals. The phenotype of DCs in patients with ankylosing spondylitis (AS) has not been evaluated. Monocyte-derived DCs (MDDCs) were grown from patients with active AS and age-matched healthy volunteers. Surface expression of HLA-DR, co-stimulation molecules CD80, CD86 and CD40, as well as CD83 was assessed by flow cytometry and compared between the groups under 3 conditions: in resting state, after stimulation by lipopolysaccharide (LPS) and... Inflammation journals http://www.medworm.com/rss/comments.php?id=5129816 Thu, 11 Aug 2011 05:57:05 +0100 5129816 http://www.medworm.com/index.php?rid=5129815&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4453870u1urw53x5%2F This study was undertaken to clarify the effects of taurine on liver injury in rats with severe acute pancreatitis (SAP). Rats were randomly assigned to three groups: a sham operation (SO), a SAP (established by infusion of 5% taurocholate), and a SAP given taurine (Taur). At 12 and 24 h post-operation, taurine pretreatment significantly attenuated hepatic tissue injury induced by SAP, and concurrently, serum alanine aminotransferase, aspartate transaminase, and amylase levels were significantly reduced by taurine pretreatment. Compared with the SO group, the total and phosphorylated p38 mitogen-activated protein kinase (p38 MAPK) expression and nuclear factor-κB (NF-κB) activity of Kupffer cells (KCs) were significantly higher in the SAP group, but taurine pretreatment inhibi... Inflammation journals http://www.medworm.com/rss/comments.php?id=5129815 Thu, 11 Aug 2011 05:57:05 +0100 5129815 http://www.medworm.com/index.php?rid=5124303&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fcw85ulw2861w80t0%2F Abstract  In the present study, we investigated the effects of Alpinia katsumadai HAYATA (Zingiberaceae) seed ethanolic extract (AKEE) and its three components on the production of inflammatory mediators and some potential underlying mechanisms in lipopolysaccharide (LPS)-induced inflammation RAW264.7 cells. The whole formula, AKEE, and three major component compounds were then evaluated for their effects on inflammation-related parameters using LPS-induced RAW264.7 cells. Production of namely nitric oxide (NO) and cytokine levels were measured by the Griess reagent and ELISA, respectively. To investigate the underlying mechanisms of anti-inflammatory activities of AKEE, protein expression of nitric oxide synthase (inducible nitric oxide synthase, iNOS), heme oxygenase-1 (HO... Inflammation journals http://www.medworm.com/rss/comments.php?id=5124303 Wed, 10 Aug 2011 15:40:23 +0100 5124303 http://www.medworm.com/index.php?rid=5124304&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe8765w5783q21376%2F Abstract  The aim of our study was to evaluate the pro- and anti-inflammatory cytokine response during acute pancreatitis and its predictive value on severity of disease. A hospital-based prospective clinical study was conducted. Twenty patients with acute pancreatitis were enrolled during a 12-month period. Plasma concentrations of TNF-α, IL-1β, IL-6, and IL-10 were determined at days 1, 2, 3, 6, and 9. The patient population was analyzed by type of acute pancreatitis. Severity was defined according to the Atlanta criteria for assessing severity of acute pancreatitis. Clinical variables were recorded to patients classified in one of two groups: severe acute pancreatitis (SAP group) and mild acute pancreatitis (MILD group). Patients with SAP had significantly higher avera... Inflammation journals http://www.medworm.com/rss/comments.php?id=5124304 Mon, 08 Aug 2011 19:54:05 +0100 5124304 http://www.medworm.com/index.php?rid=5102655&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F267t532336164416%2F Abstract  “Low-grade” systemic inflammation is common findings in patients with metabolic syndrome (MetS). When we assessed 256 MetS patients, we found eight patients who presented high levels of C-reactive protein (CRP) which are between 40 and 15 mg/L for more than 3 years. They have not satisfied any criteria of inflammatory diseases such as rheumatoid arthritis and the area of visceral fat estimated by computed tomography was more than 200 cm2. All the other MetS patients of visceral fat over 200 cm2 presented low levels of CRP which are less than 10 mg/L. Insulin resistance and ultrasound study of carotid plaques showed no differences between high and low levels of CRP patients. There are a series of MetS patients who show high levels of CRP ... Inflammation journals http://www.medworm.com/rss/comments.php?id=5102655 Tue, 02 Aug 2011 06:16:11 +0100 5102655 http://www.medworm.com/index.php?rid=5102656&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh858966302184h51%2F Abstract  The aim of the present study was to determine whether timing of insulin administration influences the hepatic and serum proinflammatory and anti-inflammatory cytokines during endotoxemia stimulated by lipopolysaccharide (LPS). Eighty-one male Sprague–Dawley rats were divided into different time groups and insulin was given 30 min pre-LPS administration or hour 0, 1, 3, 6, 12, 24 after the induction of endotoxemia, respectively. Hepatic and serum proinflammatory cytokines IL-1β, IL-6, and TNF-α, and anti-inflammatory cytokine IL-10 were detected 24 and 48 h after the induction of endotoxemia. Compared with sham control rats, serum concentrations of proinflammatory cytokines IL-1β, IL-6, and TNF-α and anti-inflammatory cytokine IL-10 significantl... Inflammation journals http://www.medworm.com/rss/comments.php?id=5102656 Tue, 02 Aug 2011 06:16:10 +0100 5102656 http://www.medworm.com/index.php?rid=5085144&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy05m4k0m42244731%2F In conclusion, endotoxemia leads to tyrosine nitration and DNA base modification that can be assessed by 3-NT and 8-OHdG, respectively. Taurine did not exhibit any antioxidant effect; moreover, it may contribute to neuronal damage at this dose. Thus, we can suggest that lower dose of taurine administration may be benefial for neuronal protection or adversely taurine administration may have toxic effect at all doses. Content Type Journal ArticlePages 1-6DOI 10.1007/s10753-011-9359-8Authors Gonca Ozan, Tubitak, Ankara, TurkeyNurten Turkozkan, Department of Biochemistry, Faculty of Medicine, Gazi University, Ankara, TurkeyFiliz Sezen Bircan, Department of Biology, Faculty of Science, Gazi University, Teknikokullar, Ankara, TurkeyBarbaros Balabanli, Department of Biology, Faculty of... Inflammation journals http://www.medworm.com/rss/comments.php?id=5085144 Fri, 29 Jul 2011 16:05:02 +0100 5085144 http://www.medworm.com/index.php?rid=5085145&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl301166n92348401%2F Abstract  We assessed whether radon inhalation inhibited carrageenan-induced inflammation in mice. Carrageenan (1% v/v) was injected subcutaneously into paws of mice that had or had not inhaled approximately 2,000 Bq/m3 of radon for 24 h. Radon inhalation significantly increased superoxide dismutase (SOD) and catalase activities and significantly decreased lipid peroxide levels in mouse paws, indicating that radon inhalation activates antioxidative functions. Carrageenan administration induced paw edema and significantly increased tumor necrosis factor-alpha (TNF-α) and nitric oxide in serum. However, radon inhalation significantly reduced carrageenan-induced paw edema. Serum TNF-α levels were lower in the radon-treated mice than in sham-treated mice. In addition,... Inflammation journals http://www.medworm.com/rss/comments.php?id=5085145 Thu, 28 Jul 2011 15:59:37 +0100 5085145 http://www.medworm.com/index.php?rid=5076212&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8165876x476r6231%2F In this report, using in situ hybridization we demonstrated that the ciliated cells in mouse lung selectively express Sec14l3 mRNA. In a three-dimensional culture of mouse tracheal epithelial cells, levels of the Sec14l3 mRNA correlated with the differentiation of ciliated cells. Intranasal infection of adult mice with influenza virus resulted in a 20-fold, progressive decrease in Sec14l3 mRNA expression over 10 days post infection. These results enhance the potential value of Sec14l3 as a ciliated epithelial cell-specific biomarker for the progression of airway inflammations such as airway viral infection and asthma. Content Type Journal ArticlePages 1-11DOI 10.1007/s10753-011-9363-zAuthors Lihua Shan, GlaxoSmithKline K.K., Tokyo, JapanShinobu Noritake, GlaxoSmithKline K.K.,... Inflammation journals http://www.medworm.com/rss/comments.php?id=5076212 Wed, 27 Jul 2011 15:47:18 +0100 5076212 http://www.medworm.com/index.php?rid=5076213&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fkn317335477jk728%2F Abstract  The purpose of this research is to study the effect of genistein on cytokines or growth factor-induced proliferation and transformation phenotype of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS). RA-FLS were primarily cultured. With respective stimulation of IL-1β, TNF-α, and EGF, genistein was applied to elucidate its effect on synoviocytes’ growth number, cell proliferation assay, cell cycle using cell counts, 3H-TdR incorporation and flow cytometry, the colony numbers under anchorage-independent condition, and the expression of MMP-2 and MMP-9 in synovial fibroblasts. EGF, IL-1β, and TNF-α increased 3H incorporation in RA-FLS, respectively. EGF augmented clone numbers of RA-FLS under anchorage-independent condition and not IL-1β and TNF-α. G... Inflammation journals http://www.medworm.com/rss/comments.php?id=5076213 Tue, 26 Jul 2011 15:50:19 +0100 5076213 http://www.medworm.com/index.php?rid=5068445&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl6k9233821612l78%2F Abstract  T helper (Th)1/Th2 balance determines the direction of some kinds of autoimmune diseases. The involvement of acini areas by CD4+ helper T(Th) cell subset in submandibular and lacrimal glands are largely unknown in secondary Sjögren’s syndrome (sSjS) with systemic lupus erythematosus (SLE). Submandibular and lacrimal glands were examined immunopathologically in lupus-prone female NZB × NZW(B/W)F1 mice, model for human sSjS with SLE. Dacryoadenitis and sialoadenitis with renal failure developed with age. Infiltration of lymphoid cells (lymphocytes and plasma cells) expanded from the periductal areas in striated ducts to the acini, and the isolated foci in the acini were observed in those organs. The destruction of duct and acini epithelium, including the myoe... Inflammation journals http://www.medworm.com/rss/comments.php?id=5068445 Fri, 22 Jul 2011 17:07:27 +0100 5068445 http://www.medworm.com/index.php?rid=5061308&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh50770w323483617%2F Abstract  The aim of this study was to investigate the association of CRP levels with type 2 diabetes (T2D) and its related variables in a sample of the Tunisian population. Our sample included 129 patients with T2D and 187 control subjects. Body mass index (BMI), plasma lipids, glucose, insulin, and CRP concentrations were measured for each participant. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. T2D was defined as a fasting plasma glucose (FPG) level ≥ 7.0 mmol/L, the use of anti-diabetic drugs, or both. Statistical analyses were performed using SPSS 11.5. A significant difference in mean values of BMI, plasma lipids, FPG, insulin, and HOMA-IR was observed between subjects with and without T2D. CRP level was significantly higher... Inflammation journals http://www.medworm.com/rss/comments.php?id=5061308 Tue, 19 Jul 2011 05:45:38 +0100 5061308 http://www.medworm.com/index.php?rid=5061309&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F18t7527j0krk52p6%2F Abstact  The possibility of inflammation and neutrophil activation in response to indoor air pollution (IAP) from biomass fuel use has been investigated. For this, 142 premenopausal, never-smoking women (median age, 34 years) who cook exclusively with biomass (wood, dung, crop wastes) and 126 age-matched control women who cook with cleaner fuel liquefied petroleum gas (LPG) were enrolled. The neutrophil count in blood and sputum was significantly higher (p < 0.05) in biomass users than the control group. Flow cytometric analysis revealed marked increase in the surface expression of CD35 (complement receptor-1), CD16 (FCγ receptor III), and β2 Mac-1 integrin (CD11b/CD18) on circulating neutrophils of biomass users. Besides, enzyme-linked immunosorbent assay showe... Inflammation journals http://www.medworm.com/rss/comments.php?id=5061309 Tue, 19 Jul 2011 05:45:37 +0100 5061309 http://www.medworm.com/index.php?rid=5048091&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fwl85np3377866706%2F Abstract  Human formylpeptide receptor 2 (FPR2) and its mouse homologue mFPR2 belong to the G protein-coupled, seven-transmembrane receptor superfamily. Both FPR2 and mFPR2 recognize a variety of exogenous and host-derived chemotactic peptides associated with proinflammatory conditions. Since endothelial cells actively participate in inflammation, we investigated whether microvascular endothelial cells express mFPR2 and its regulation by proinflammatory factors. We found that resting primary mouse microvascular endothelial cells and a cell line bEnd.3 expressed low levels of mFPR2 at both mRNA and protein levels, which was markedly enhanced by two key proinflammatory stimulants, lipopolysaccharide (LPS) and interleukin (IL)-1β. While the inductive effect of LPS was depende... Inflammation journals http://www.medworm.com/rss/comments.php?id=5048091 Thu, 14 Jul 2011 16:50:29 +0100 5048091 http://www.medworm.com/index.php?rid=5035343&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk822561g5k2875h4%2F Abstract  Osteoarthritis (OA) is considered a complex illness, characterized by cartilage degeneration, secondary synovial membrane inflammation, and subchondral bone sclerosis. Previous studies have shown β1,4-galactosylransferase-I (β1,4-GalT-I) to be a key inflammatory mediator that participates in the initiation and maintenance of inflammatory reaction in diseases. In the present study, we investigated the expression and possible biological function of β1,4-GalT-I in the cartilage and synovial tissue of OA patients. Cartilage and synovial tissue samples from OA patients and healthy controls were stained for β1,4-GalT-I. Reverse transcription-polymerase chain reaction was used to observe the expression of β1,4-GalT-I, and western blot was carried out for E-selectin.... Inflammation journals http://www.medworm.com/rss/comments.php?id=5035343 Wed, 13 Jul 2011 06:17:59 +0100 5035343 http://www.medworm.com/index.php?rid=5017645&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy858g082682k267h%2F Abstract  C-C chemokine receptor 7 (CCR7) and its chemoattractant agonist CCL21 promote cell migration and expression of pro-inflammatory proteins in an atherogenic environment. Since A2A adenosine receptor activation reduces migration and inflammatory effects, we examined its effect on CCR7 expression and migration. CCR7 protein expression decreased by about a third in macrophages treated with A2A receptor agonist CGS 21680 (p = 0.028, n = 7) and was reversed with antagonist, although mRNA levels increased twofold (p = 0.001, n = 3). Furthermore, macrophages treated with CGS 21680 showed a significant decrease in migration (p = 0.0311, n = 7). These results suggest that A2A adenosine receptor activation not only modulates CCR7 expression in both normal ... Inflammation journals http://www.medworm.com/rss/comments.php?id=5017645 Fri, 08 Jul 2011 06:29:57 +0100 5017645 http://www.medworm.com/index.php?rid=4991595&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5461473345386385%2F Abstract  The aim of this study is to compare the expression of TIM-3 from CD4+ T cells from rheumatoid arthritis (RA) patients and healthy controls and to evaluate the effect of galectin-9 (Gal-9) on apoptosis of CD4+ T cells in these patients. CD4+ T cells from RA patients and healthy controls were isolated from peripheral blood mononuclear cells and were activated. The expression of TIM-3 mRNA in CD4+ T cells was measured using real-time polymerase chain reaction. CD4+ T cells were activated in the presence of graded doses of Gal-9 or control, and Gal-9-induced cytotoxicity and apoptotic activity of CD4+ T cells were analyzed using MTT assays and annexin-V staining, respectively. TIM-3 mRNA expression was significantly lower in CD4+ T cells from RA patients compared with... Inflammation journals http://www.medworm.com/rss/comments.php?id=4991595 Wed, 29 Jun 2011 15:50:39 +0100 4991595 http://www.medworm.com/index.php?rid=4935804&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000004%2Fart00009 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=4935804 Sat, 18 Jun 2011 14:01:21 +0100 4935804 http://www.medworm.com/index.php?rid=4935803&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000004%2Fart00008 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=4935803 Sat, 18 Jun 2011 14:01:21 +0100 4935803 http://www.medworm.com/index.php?rid=4935802&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000004%2Fart00007 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=4935802 Sat, 18 Jun 2011 14:01:21 +0100 4935802 http://www.medworm.com/index.php?rid=4935801&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000004%2Fart00006 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=4935801 Sat, 18 Jun 2011 14:01:21 +0100 4935801 http://www.medworm.com/index.php?rid=4935800&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000004%2Fart00005 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=4935800 Sat, 18 Jun 2011 14:01:21 +0100 4935800 http://www.medworm.com/index.php?rid=4935799&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000004%2Fart00004 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=4935799 Sat, 18 Jun 2011 14:01:21 +0100 4935799 http://www.medworm.com/index.php?rid=4935798&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000004%2Fart00003 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=4935798 Sat, 18 Jun 2011 14:01:21 +0100 4935798 http://www.medworm.com/index.php?rid=4935797&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000004%2Fart00002 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=4935797 Sat, 18 Jun 2011 14:01:21 +0100 4935797 http://www.medworm.com/index.php?rid=4935796&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000004%2Fart00001 This article is currently available as a free download on ingentaconnect (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=4935796 Sat, 18 Jun 2011 02:15:53 +0100 4935796 http://www.medworm.com/index.php?rid=4931955&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb3h7135054066tr1%2F In this study, we examined whether a Diospyros blancoi methanolic extract (DBE) exerts protective effects on allergic asthma in a murine asthma model. To investigate the specific role of DBE, we employed a murine model of allergic airway inflammation. BALB/c mice sensitized and challenged with ovalbumin (OVA) were orally administered 20 or 40 mg/kg DBE for 3 days during OVA challenge. DBE induced significant suppression of the number of OVA-induced total inflammatory cells, including eosinophils, macrophages, and lymphocytes, in bronchoalveolar lavage fluid (BALF). Moreover, treatment with DBE led to significant decreases in interleukin (IL)-4, IL-5, and eotaxin levels in BALF and OVA-specific immunoglobulin (Ig)E and IgG1 levels in serum. Histological examination of lung t... Inflammation journals http://www.medworm.com/rss/comments.php?id=4931955 Sat, 11 Jun 2011 06:37:52 +0100 4931955 http://www.medworm.com/index.php?rid=4919886&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc7ur208111277128%2F Content Type Journal ArticlePages 1-2DOI 10.1007/s10753-011-9351-3Authors Joong Kyong Ahn, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of KoreaJi-Won Hwang, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Gangnam-gu, Seoul, 135-710 Republic of KoreaEun-Kyung Bae, Center for Molecular Medicine, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, Republic of KoreaJaejoon Lee, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Gangnam-gu, Seoul, 135-710 Republic of KoreaChan Hong Jeon, Department of Internal Medicine, Soonchunhyang University College of Medicine, S... Inflammation journals http://www.medworm.com/rss/comments.php?id=4919886 Tue, 07 Jun 2011 15:51:06 +0100 4919886 http://www.medworm.com/index.php?rid=4919887&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu4q254tt5666nk92%2F Abstract  Recent genome-wide association studies have related several genetic loci, including C-reactive protein (CRP), hepatocyte nuclear factor 1 homeobox (HNF1A), and genetic variations in the leptin receptor (LEPR), to circulating CRP levels in populations of European ancestry. The genetic effects in other populations and across varying levels of exposure to a pathogenic environment, an important environmental factor associated with CRP, remain to be determined. We tested 2,073,674 single-nucleotide polymorphisms (SNPs) for association with plasma CRP (limited to ≤10 mg/L) in 1,709 unrelated Filipino women from the Cebu Longitudinal Health and Nutrition Survey. The strongest evidence of association was observed with variants at CRP (rs876537, P = 1.4 × 10�... Inflammation journals http://www.medworm.com/rss/comments.php?id=4919887 Tue, 07 Jun 2011 05:47:03 +0100 4919887 http://www.medworm.com/index.php?rid=4900993&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft27r2uu826313h40%2F In conclusion, our results demonstrated that oxymatrine is potentially capably of protecting against l-arginine-induced AP and attenuating AP-associated intestinal barrier injury by up-regulation of claudin-1. Content Type Journal ArticlePages 1-9DOI 10.1007/s10753-011-9352-2Authors Zhiqiang Zhang, Department of General Surgery, The People’s Hospital of Liaoning Province, 33 Wenyi Road, Shenyang, 110016 People’s Republic of ChinaYanqing Wang, Department of General Surgery, The People’s Hospital of Liaoning Province, 33 Wenyi Road, Shenyang, 110016 People’s Republic of ChinaMing Dong, Department of General Surgery, The First Affiliated Hospital of China Medical University, Shenyang, 110001 People’s Republic of ChinaJianchun Cui, Department of General Surgery, The People’... Inflammation journals http://www.medworm.com/rss/comments.php?id=4900993 Thu, 02 Jun 2011 06:06:57 +0100 4900993 http://www.medworm.com/index.php?rid=4900994&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F49gn16v15263843m%2F Abstract  Curcumin is a pleiotropic molecule against inflammatory related diseases. However, poor bioavailability greatly limits its application in clinic. Our previous study synthesized and evaluated a hydrosoluble mono-carbonyl analogue of curcumin, (2E,5E)-2,5-bis(4-(3-(dimethylamino)-propoxy)benzylidene)cyclopentanone (A13). In the present study, we further evaluated the anti-inflammatory effect of A13 in vivo. In lipopolysaccharide-challenged mice, pretreatment of A13 (15 mg/kg, i.v.) attenuated the increase of plasma level of NO, TNF-α, and IL-6, significantly inhibited the increase of hepatic inflammatory gene transcription, and improved pulmonary damages. In addition, A13 (10 or 30 mg/kg, i.p.) reduced vascular permeability in Institute of Cancer Research m... Inflammation journals http://www.medworm.com/rss/comments.php?id=4900994 Thu, 26 May 2011 05:44:45 +0100 4900994 http://www.medworm.com/index.php?rid=4900995&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj6l0x5k5p4785825%2F In conclusion, vitexicarpin significantly reduced vascular inflammation, through inhibition of ROS–NF-κB pathway in vascular endothelial cells. Content Type Journal ArticlePages 1-10DOI 10.1007/s10753-011-9349-xAuthors So Min Lee, College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Chonbuk 570-749, Republic of KoreaYun Jung Lee, College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Chonbuk 570-749, Republic of KoreaYoun Chul Kim, College of Pharmacy, Wonkwang University, Iksan, Chonbuk 570-749, Republic of KoreaJin Sook Kim, Korea Institute of Oriental Medicine, Jeonmin-dong, Yusung-gu, Daejeon, 305-811 Republic of KoreaDae Gill Kang, College of Oriental Medicine... Inflammation journals http://www.medworm.com/rss/comments.php?id=4900995 Wed, 25 May 2011 16:05:51 +0100 4900995 http://www.medworm.com/index.php?rid=4900996&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Frj37272477585225%2F Abstract  The endothelial barrier controls the passage of solutes from the vascular space. This is achieved through active reorganization of the actin cytoskeleton. A central cytoskeletal protein involved into this is vasodilator-stimulated phosphoprotein (VASP). However, the functional role of endothelial VASP during hypoxia has not been thoroughly elucidated. We determined endothelial VASP expression through real-time PCR (Rt-PCR), immunhistochemistry, and Western blot analysis during hypoxia. VASP promoter studies were performed using a PGL3 firefly luciferase containing plasmid. Following approval by the local authorities, VASP −/− mice and littermate controls were subjected to normobaric hypoxia (8% O2, 92% N2) after intravenous injection of Evans blue dye. In in... Inflammation journals http://www.medworm.com/rss/comments.php?id=4900996 Mon, 23 May 2011 17:07:59 +0100 4900996 http://www.medworm.com/index.php?rid=4861035&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp330m16161121u83%2F Abstract  Parthenolide, a naturally occurring sesquiterpene lactone derived from feverfew (Tanacetum parthenium), exhibits exceptional anti-cancer and anti-inflammatory properties, making it a prominent candidate for further studies and drug development. In this review, we briefly investigate molecular events and cell-specific activities of this chemical in relation to cytochrome c, nuclear factor kappa-light-chain enhancer of activated B cells (NF-κB), signal transduction and activation of transcription (STAT), reactive oxygen species (ROS), TCP, HDACs, microtubules, and inflammasomes. This paper reports that parthenolide shows strong NF-κB- and STAT-inhibition-mediated transcriptional suppression of pro-apoptotic genes. This compound acts both at the transcriptional leve... Inflammation journals http://www.medworm.com/rss/comments.php?id=4861035 Fri, 20 May 2011 16:11:43 +0100 4861035 http://www.medworm.com/index.php?rid=4861037&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F72t3t6153h4tpv12%2F Abstract  Sepsis-related systemic inflammation frequently occurs in the critical care setting. Systemic inflammation is implicated in the progression of organ injury, which is associated with a high mortality rate. Recently, vitamin E and glutamic acid have been reported to attenuate inflammation. We therefore investigated whether the vitamin E derivative, ETS-GS, could inhibit the secretion of cytokines and high-mobility group box 1 (HMGB1), and thereby reduce organ damage in a rat model of cecal ligation and puncture (CLP)-induced sepsis. Male Wistar rats weighing 250–300 g were used. Rats received water or ETS-GS (10 mg/kg) by oral administration for 3 weeks, and then sepsis was induced by CLP under sevoflurane anesthesia. Serum levels of interleukin... Inflammation journals http://www.medworm.com/rss/comments.php?id=4861037 Fri, 20 May 2011 16:11:42 +0100 4861037 http://www.medworm.com/index.php?rid=4861036&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff34718x372525p63%2F Abstract   Elaeocarpus petiolatus is known to exert active oxygen scavenging, anti-aging, and whitening actions. However, the biological effects of E. petiolatus on inflammation and the underlying mechanisms are yet to be established. In the present study, we investigated the anti-inflammatory effects of the ethanol extract from E. petiolatus (EPE) bark in murine Raw264.7 macrophages stimulated with lipopolysaccharide (LPS). EPE inhibited the production of PGE2, TNF-α, and IL-1β in a dose-dependent manner in Raw264.7 cells stimulated with LPS. The decrease in PGE2 production was correlated with reduced COX-2 expression. Furthermore, EPE suppressed the phosphorylation of extracellular signal-related kinases (ERK), c-Jun N-terminal kinase (JNK), and p38 as well as translocatio... Inflammation journals http://www.medworm.com/rss/comments.php?id=4861036 Fri, 20 May 2011 16:11:42 +0100 4861036 http://www.medworm.com/index.php?rid=4852170&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F787345338868416m%2F Abstract  Human β-defensin-2 (HBD-2), an antimicrobial peptide produced by epithelial cells, plays an important role in the body’s innate and adaptive immunity. High-mobility group N2 (HMGN2), a member of the HMG superfamily, binds to chromatin to modulate gene transcription. Previously, we have shown that HMGN2 acts as a positive modulator of the signal transduction cascade in the process of inducible human β-defensin expression. In our current study, we found that down-regulation of HMGN2 reduces the expression level of murine β-defensin-3 and -4 (mBD-3 and mBD-4), but not mBD-1 upon LPS stimulation in various tissues of pregnant ICR mice, as well as in embryonic and neonatal lungs and livers at different developmental time points. In the control group, murine HMGN2 ... Inflammation journals http://www.medworm.com/rss/comments.php?id=4852170 Wed, 18 May 2011 18:19:21 +0100 4852170 http://www.medworm.com/index.php?rid=4852171&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fgn483558688ukp42%2F This study revealed that as macrophages were activated by LPS, NE promoted the secretion of inflammatory factors by increasing the phosphorylation of MAPKs through an α receptor-dependent pathway. Our results provide the evidence of a relationship between stress and diseases, as well as the mechanism by which stress induces or affects the inflammation-related diseases. Content Type Journal ArticlePages 1-8DOI 10.1007/s10753-011-9342-4Authors Jun-Long Huang, Department of Military Nautical Medicine, Laboratory of Stress Medicine, Faculty of Naval Medicine, Second Military Medical University, Xiangyin Road 800, Shanghai, 200433 People’s Republic of ChinaYou-Lei Zhang, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200433 People’s Republic... Inflammation journals http://www.medworm.com/rss/comments.php?id=4852171 Wed, 18 May 2011 06:13:57 +0100 4852171 http://www.medworm.com/index.php?rid=4852172&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp388522723085870%2F Abstract  Nitric oxide (NO) production and carbon monoxide (CO) production are increased in inflammatory lung diseases. Although there are some pieces of evidence for hormonal modulation by estrogen, little is known about exhaled NO and CO during the ovarian cycle. In 23 subjects, we measured exhaled NO and CO by an online analyzer. Significantly higher levels of exhaled NO were found at the midcycle compared with those in the premenstrual period or during menstruation. Higher levels of CO were after ovulation and reached a peak in the premenstrual phase. The lowest levels of CO were observed in the first days of the estrogen phase. In males, there was no significant variation in exhaled NO and CO. Exhaled NO and CO levels vary during the ovarian cycle in women, and this fa... Inflammation journals http://www.medworm.com/rss/comments.php?id=4852172 Wed, 18 May 2011 06:13:56 +0100 4852172 http://www.medworm.com/index.php?rid=4819472&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6tl35573x546526g%2F In conclusion, treatment with IRAP enhanced neuronal survival after SCI. Content Type Journal ArticlePages 1-7DOI 10.1007/s10753-011-9341-5Authors Shaohui Zong, Department of Spine Osteopathia, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People’s Republic of ChinaGaofeng Zeng, College of Public Hygiene of Guangxi Medical University, No. 22 Shuangyong Road, Nanning, 530021 Guangxi, People’s Republic of ChinaBo Wei, College of Public Hygiene of Guangxi Medical University, No. 22 Shuangyong Road, Nanning, 530021 Guangxi, People’s Republic of ChinaChunxiang Xiong, Graduate School of Guangxi Medical University, Nanning, Guangxi, People’s Republic of ChinaYuxi Zhao, Graduate School of Guangxi Medical University, Nanning, Guangxi, People’s Repub... Inflammation journals http://www.medworm.com/rss/comments.php?id=4819472 Wed, 11 May 2011 06:24:05 +0100 4819472 http://www.medworm.com/index.php?rid=4819473&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F53858000792580u8%2F Abstract  Fibroblast-like synoviocytes (FLS) play an important role in the pathogenesis of rheumatoid arthritis. Raf kinase inhibitor protein (RKIP) negatively regulates the Raf/MEK/ERK and NF-κB pathway. The role of RKIP in rheumatoid FLS is unknown. The purpose of the present study was to investigate the function of RKIP in rheumatoid FLS. Rheumatoid FLS were transfected with either RKIP-expressing plasmids or RKIP small interfering RNA (siRNA). RKIP protein was detected in rheumatoid synovial tissue (ST) and FLS. RKIP overexpression significantly decreased IL-6 mRNA expression in TNF-α-stimulated rheumatoid FLS. RKIP overexpression also showed a decreased trend in IL-8, MMP-1, and MMP-3 mRNA expression in TNF-α-stimulated rheumatoid FLS. RKIP silencing resulted in sig... Inflammation journals http://www.medworm.com/rss/comments.php?id=4819473 Tue, 10 May 2011 06:01:58 +0100 4819473 http://www.medworm.com/index.php?rid=4819475&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F40283n36628g1115%2F Abstract  We have recently reported that Ras acts as an intermediate coactivator in IL-1β-mediated hypoxia-inducible factor-1α (HIF-1α) activation in glioblastoma multiforme (GBM). Since HIF-1α plays a crucial role in linking inflammatory and oncogenic pathways, we investigated whether this IL1β-Ras-HIF-1α signaling axis observed in GBM also exists in other tumors of diverse origin under normoxia. Treatment with IL-1β induced Ras in non-GBM cell lines A549 (lung), HeLa (cervical), and HepG2 (liver), and inhibition of Ras activity attenuated HIF-1α activity. Our findings suggest that Ras links IL-1β and HIF-1α in tumors of diverse origin. As we have previously reported that the farnesyltransferase inhibitor manumycin decreases Ras activity in glioma cells, we inves... Inflammation journals http://www.medworm.com/rss/comments.php?id=4819475 Tue, 10 May 2011 06:01:57 +0100 4819475 http://www.medworm.com/index.php?rid=4819474&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc3884t8632u771n0%2F Abstract  The aim of this study is to compare the response of interleukin-6 (IL-6) and soluble tumor necrosis factor alpha receptor 1 (s-TNFr1) to two submaximal intensities of exercise in individuals with heart failure (HF). Thirty-two HF individuals aged 45.53 ± 9.41 years, classes II and III of the New York Heart Association (NYHA) classification underwent two sessions of exercise at low and moderate intensities with blood analysis at baseline, exercise and after exercise. The differences were evaluated by Friedman test and factorial ANOVA. Alpha = 5% was considered. No difference in IL-6 was detected for low intensity. At moderate intensity, there was a significant increase after exercise. The s-TNFr1 increased in moderate-intensity exercise and went back ... Inflammation journals http://www.medworm.com/rss/comments.php?id=4819474 Tue, 10 May 2011 06:01:57 +0100 4819474 http://www.medworm.com/index.php?rid=4789969&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000003%2Fart00009 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=4789969 Fri, 06 May 2011 13:57:28 +0100 4789969 http://www.medworm.com/index.php?rid=4789968&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000003%2Fart00008 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=4789968 Fri, 06 May 2011 13:57:28 +0100 4789968 http://www.medworm.com/index.php?rid=4789967&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000003%2Fart00007 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=4789967 Fri, 06 May 2011 13:57:28 +0100 4789967 http://www.medworm.com/index.php?rid=4789966&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000003%2Fart00006 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=4789966 Fri, 06 May 2011 13:57:28 +0100 4789966 http://www.medworm.com/index.php?rid=4789965&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000003%2Fart00005 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=4789965 Fri, 06 May 2011 13:57:28 +0100 4789965 http://www.medworm.com/index.php?rid=4789964&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000003%2Fart00004 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=4789964 Fri, 06 May 2011 13:57:28 +0100 4789964 http://www.medworm.com/index.php?rid=4789963&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000003%2Fart00003 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=4789963 Fri, 06 May 2011 13:57:28 +0100 4789963 http://www.medworm.com/index.php?rid=4789962&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000003%2Fart00002 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=4789962 Fri, 06 May 2011 13:57:28 +0100 4789962 http://www.medworm.com/index.php?rid=4789961&cid=s_33909_3_f&fid=33909&url=http%3A%2F%2Fwww.ingentaconnect.com%2Fcontent%2Fben%2Fiadt%2F2011%2F00000010%2F00000003%2Fart00001 (Source: Inflammation) Inflammation journals http://www.medworm.com/rss/comments.php?id=4789961 Fri, 06 May 2011 02:15:09 +0100 4789961 http://www.medworm.com/index.php?rid=4811824&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fcl88133806p3075l%2F In conclusion, high cytokine levels, recruitment of inflammatory cells (eosinophils and neutrophils), and increased IgE concentration may contribute to the exacerbation and maintenance of the induced inflammatory response in lungs by scorpion venom. These results lead to the better understanding of this induced pathogenesis and could help the physicians to take care of envenomed patients. Content Type Journal ArticlePages 1-8DOI 10.1007/s10753-011-9338-0Authors Sonia Adi-Bessalem, Laboratoire de Biologie Cellulaire et Moléculaire, Faculté des Sciences Biologiques, Université des Sciences et de la Technologie Houari Boumédienne, BP 32, El-Alia Bab Ezzouar, 16111 Algiers, AlgeriaAmina Mendil, Laboratoire de Biologie Cellulaire et Moléculaire, Faculté des Sciences Biologiques,... Inflammation journals http://www.medworm.com/rss/comments.php?id=4811824 Thu, 05 May 2011 16:35:45 +0100 4811824 http://www.medworm.com/index.php?rid=4788017&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fpxh31q31t0734646%2F Abstract  Bradykinin, a vasoactive peptide, increases during inflammation and induces the formation of prostaglandins through specific receptor activation. Two types of receptors mediate the biological effects of bradykinin, B1 and B2 receptors. Although B2 receptors are present in most tissues, B1 receptors are expressed after inflammatory stimuli or tissue injury. Bradykinin has a high affinity for B2 and a low affinity for B1 receptors, whereas the opposite occurs for des-Arg9-bradykinin. Recently, it has been reported that nonsteroidal anti-inflammatory drugs have different inhibitory activities on cyclooxygenase isozymes, COX-1, COX-2, and COX-3. In the present study, we have investigated the contributions of different COX isozyme inhibitions and inflammation on bradykini... Inflammation journals http://www.medworm.com/rss/comments.php?id=4788017 Mon, 02 May 2011 14:59:03 +0100 4788017 http://www.medworm.com/index.php?rid=4788016&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fynxn62144l6495pp%2F Abstract  Pro-inflammatory mediators produced during inflammatory response have been demonstrated to initiate and aggravate pathological development of several chronic diseases. Plant bioactive constituents have been reported to exert anti-inflammatory activities. Various parts of Moringa oleifera have long been used as habitual diets and traditional remedy along the tropical region. Anti-inflammatory activity of boiled M. oleifera pod extract was assessed by measuring pro-inflammatory mediator expression in the lipopolysaccharide-induced murine RAW264.7 macrophage cells. Prior treatment with 31–250 μg/mL M. oleifera extract for 1 h inhibited elevation of mRNA and protein level of interleukine-6, tumor necrosis factor-alpha, inducible nitric oxide synthase, and ... Inflammation journals http://www.medworm.com/rss/comments.php?id=4788016 Mon, 02 May 2011 14:59:03 +0100 4788016 http://www.medworm.com/index.php?rid=4779597&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe6v9jn285nx7717n%2F Abstract  Molecular mechanisms of sepsis-associated acute lung injury (ALI) are poorly defined. Since vascular endothelial growth factor (VEGF) is a potent vascular permeability and mitogenic factor, it might contribute to the development of ALI in sepsis. Thus, using lipopolysaccharide (LPS)-induced (15 mg/kg, intraperitoneal) endotoxemic rat model, we studied the timeline (1, 3, 6, and 10 h) of pulmonary VEGF expression and its signaling machinery. Levels of pulmonary VEGF and its angiogenic-mediating receptor, Flk-1, were downregulated by LPS in a time-dependent manner; levels of plasma VEGF and its permeability-mediating receptor, Flt-1, in contrast, was upregulated with time. In addition, blockade of Flt-1 could improve the downregulated pulmonary VEGF level ... Inflammation journals http://www.medworm.com/rss/comments.php?id=4779597 Thu, 28 Apr 2011 17:16:46 +0100 4779597 http://www.medworm.com/index.php?rid=4744609&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe5817422636u1107%2F Abstract  The prevalence of CD4+CD25high regulatory T cells (Tregs) in patients with acute-on-chronic liver failure (AoCLF) who received plasma exchange (PE) and/or medical treatment was investigated. One hundred five patients with AoCLF in two groups (PE plus routine-care, n = 48 and routine-care, n = 57) were enrolled in our study. In the PE group, there were 27 survivors (27/48) while, in the routine-care group, there were 18 survivors (18/57), both after 30 days treatment. Twenty-three healthy donors were used as the control group. Tregs were determined by flow cytometry serially. In the survivors, Tregs frequency were lower compared with the normal controls on admission and showed an up and down tendency; moreover, this frequency turned to the level as that ... Inflammation journals http://www.medworm.com/rss/comments.php?id=4744609 Wed, 20 Apr 2011 06:05:57 +0100 4744609 http://www.medworm.com/index.php?rid=4744610&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw357uu7711nn582p%2F In this study, we investigated the anti-inflammatory activities of the methylene chloride fraction of JP05 (JP05-MC) on the production of inflammatory mediators in lipopolysaccharide (LPS)-stimulated BV2 mouse microglial cells, and its mechanism of action. JP05-MC significantly inhibited LPS-induced production of NO and the proinflammatory cytokines, TNF-α and IL-6, in BV2 cells. JP05-MC also attenuated the mRNA expression and protein levels of inducible nitric oxide synthase in LPS-induced BV2 cells. JP05-MC significantly attenuated LPS-elicited phosphorylation of the mitogen-activated protein kinase (MAPK), extracellular-signal-regulated kinase 1/2, and nuclear factor-κB (NF-κB) nuclear translocation in BV2 cells. Our results indicate that JP05-MC exerts anti-inflammatory proper... Inflammation journals http://www.medworm.com/rss/comments.php?id=4744610 Wed, 20 Apr 2011 06:05:56 +0100 4744610 http://www.medworm.com/index.php?rid=4722864&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx326460ug2164519%2F We examined whether the -C148T polymorphism is associated with pre- and early postoperative levels of fibrinogen, C-reactive protein (CRP), and interleukin-6 (IL-6) in 243 consecutive patients undergoing coronary artery bypass grafting (CABG) surgery. Plasma inflammatory markers were measured prior to and 5–7 days after surgery. The -C148T polymorphism was analyzed with the restriction fragment-length polymorphism method. The genotype distribution was as follows: CC—142 (58%), CT—85 (35%), and TT—16 (7%). Carriers of the -148T allele had higher preoperative plasma fibrinogen (4.42 ± 0.14 vs. 4.07 ± 0.11 mg/L, p = 0.04) and CRP levels (7.49 ± 1.2 vs. 4.26 ± 1.0 mg/L, p = 0.04) compared with non-carriers; 5 to 7 days after CABG, pat... Inflammation journals http://www.medworm.com/rss/comments.php?id=4722864 Fri, 15 Apr 2011 15:49:10 +0100 4722864 http://www.medworm.com/index.php?rid=4722865&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0663557w10250721%2F Abstract  The aim of our study is to determine the serum visfatin levels of patients with Behcet’s disease and to investigate the relationship between visfatin, an adipokine released from adipose tissue, levels and activity of Behcet’s disease. Fifty-eight patients with Behcet’s disease were enrolled to the study. Nineteen of the patients were inactive, and 39 of them were active. We enrolled 30 healthy subjects as being control group. Visfatin and tumor necrosis factor alpha (TNF-α) levels were measured with ELISA method. Visfatin levels were significantly lower in patients with Behcet’s disease whose illnesses were active or inactive than the control group (p < 0.05). There was no significant difference between the active patient and inactive patient group.... Inflammation journals http://www.medworm.com/rss/comments.php?id=4722865 Thu, 14 Apr 2011 17:00:28 +0100 4722865 http://www.medworm.com/index.php?rid=4722866&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff723317m06n43382%2F Abstract  High-mobility group box 1 (HMGB1) was recently established as a proinflammatory mediator of sepsis, and its potential role in the pathogenesis of sepsis remains elusive. In the present study, we determined whether HMGB1 increases the permeability of the endothelial cell monolayer in sepsis. Permeability was measured from fluorescein isothiocyanate (FITC)–dextran 40-kDa flux across the endothelial cell monolayer at control and after HMGB1 administration. We found that HMGB1 increased human umbilical vein endothelial cell permeability to FITC–dextran 40 kDa in a time- and concentration-dependent manner. HMGB1 induced the mRNA transcription and protein expression of receptor for advanced glycation end products (RAGE). Blockade of cell surface receptors ... Inflammation journals http://www.medworm.com/rss/comments.php?id=4722866 Thu, 14 Apr 2011 17:00:27 +0100 4722866 http://www.medworm.com/index.php?rid=4722867&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F701h36u87680p89x%2F Abstract  Nicotine has anti- and pro-inflammatory properties in various cells. Its role in aortic vascular smooth muscle cells (VSMC) was explored. Human aortic VSMC were cultured. After nicotine (1.0 μM) and/or pyrrolidinedithiocarbamic acid (PDTC, 50 μM) treatment, the activation of nuclear factor κB (NFκB) was investigated. The levels of pro-inflammatory cytokines, osteopontin (OPN), interleukin-6 (IL-6), and monocyte chemoattractant protein 1 (MCP-1) were also assessed. After OPN was downregulated by small interfering RNA (siRNA) transfection, the pro-inflammatory effect was reassessed. We found that NFκB was activated after nicotine administration. Nicotine upregulated OPN, IL-6, and MCP-1 expressions, and this effect attenuated after PDTC pretreatment. ... Inflammation journals http://www.medworm.com/rss/comments.php?id=4722867 Thu, 14 Apr 2011 17:00:26 +0100 4722867 http://www.medworm.com/index.php?rid=4722868&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8638hv63w1735vw2%2F Abstract  The immunological properties of rat S100A8 (r-S100A8) and S100A9 (r-S100A9) in immune cells are poorly understood. Enzyme-linked immunosorbent assay (ELISA) for r-S100A9 enabled us to discuss the differential functional roles of the two proteins, and their localization in the cells was observed microscopically. Recombinant human S100A8 (rh-S100A8) or S100A9 (rh-S100A9) were intravenously administrated into rats with LPS-induced liver damage. ELISA was used to measure the serum concentration of S100A9 in the rats. Western blotting and a preparative ELISA were used to prove specificity and avidity of monoclonal antibodies for r-S100A8 and r-S100A9. Immunohistochemical staining was carried out to visualize intracellular localization of the two proteins in the immune ... Inflammation journals http://www.medworm.com/rss/comments.php?id=4722868 Wed, 13 Apr 2011 14:34:30 +0100 4722868 http://www.medworm.com/index.php?rid=4722869&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fpgx3t109047q4531%2F This study therefore aimed to evaluate correlations between levels of soluble interleukin (IL)-2 receptor (sIL-2r), IL-6, and IL-8 and in-hospital incidence of acute heart failure (AHF) and left ventricular (LV) systolic dysfunction in the subacute phase of ACS. In 48 consecutive patients with ACS, circulating levels of sIL-2r, IL-6, and IL-8 were ascertained 72–96 h after onset of symptoms. Clinical data, LV function, and in-hospital incidence of AHF were also evaluated. IL-8 levels were significantly higher in patients with pulmonary edema (1,829 ± 2,496 vs 456 ± 624 pg/ml, p < 0.05); sIL-2r, IL-6, and IL-8 levels were increased proportionally to Killip class (r = 0.35, p < 0.05; r = 0.48, r = 0.47, p < 0.01) and in patients with... Inflammation journals http://www.medworm.com/rss/comments.php?id=4722869 Wed, 13 Apr 2011 14:34:28 +0100 4722869 http://www.medworm.com/index.php?rid=4722870&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa5v1167hw21rmwq2%2F Abstract  The purpose of this study was to investigate the potential pro-inflammatory role of the cytokine interleukin (IL-18) in oral lichen planus (OLP) so as to provide a reliable and early indicator for the diagnosis of OLP. One hundred three ethnic Chinese patients with OLP were enrolled in this study, as were 48 age- and sex-matched controls. IL-18 concentrations in serum and saliva were screened by enzyme-linked immunosorbent assay. The protein content was expressed as picograms per milliliter. OLP patients showed a high-level of IL-18 expression profile in serum compared with the control group (OLP = 21.32 ± 8.26 pg/mL, control = 12.29 ± 5.11 pg/mL, P < 0.05), and the saliva partner had significantly higher concentrations of IL-18 c... Inflammation journals http://www.medworm.com/rss/comments.php?id=4722870 Tue, 12 Apr 2011 05:59:21 +0100 4722870 http://www.medworm.com/index.php?rid=4722871&cid=s_33909_61_f&fid=35973&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr865672581t61t14%2F This study demonstrates that local activation of kappa opioid receptors decreases two important parameters of temporomandibular joint inflammation, that is, plasma extravasation and neutrophil migration, in a dose-dependent and antagonist-reversible manner. This anti-inflammatory effect taken together with the potent antinociceptive effect, suggests that drugs targeting peripheral kappa opioid receptors are promising for the treatment of inflammatory temporomandibular joint pain and probably, other articular pain conditions with an inflammatory basis. Content Type Journal ArticlePages 1-6DOI 10.1007/s10753-011-9329-1Authors Tânia C. Chicre-Alcântara, Department of Physiology, Piracicaba Dental School, State University of Campinas–UNICAMP, Piracicaba, São Paulo, BrazilKarla... Inflammation journals http://www.medworm.com/rss/comments.php?id=4722871 Tue, 12 Apr 2011 05:59:20 +0100 4722871