MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Inflammatory Bowel Diseases' source. Wed, 08 Feb 2012 16:28:19 +0100 http://www.medworm.com/index.php?rid=5667932&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22914 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5667932 Wed, 01 Feb 2012 05:00:00 +0100 5667932 http://www.medworm.com/index.php?rid=5649046&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22888 Conclusions:In this large cohort of IBD patients, risk factors for anxiety and depression were severe and active disease and socioeconomic deprivation. Psychological interventions would be useful when these factors are identified. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5649046 Wed, 01 Feb 2012 05:00:00 +0100 5649046 http://www.medworm.com/index.php?rid=5649058&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22904 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5649058 Tue, 31 Jan 2012 05:00:00 +0100 5649058 http://www.medworm.com/index.php?rid=5649057&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22903 Conclusions:Pretravel advice for IBD patients was often deficient. There was a considerable amount of travel‐related morbidity and inconvenience. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5649057 Tue, 31 Jan 2012 05:00:00 +0100 5649057 http://www.medworm.com/index.php?rid=5649056&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22901 Conclusions:While it remains difficult to determine superiority between the IGRAs and the TST, both are negatively affected by IST. Therefore, screening prior to initiation of IST should be considered. Nevertheless, it is imperative that all patients receive screening prior to anti‐TNF therapy. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5649056 Tue, 31 Jan 2012 05:00:00 +0100 5649056 http://www.medworm.com/index.php?rid=5649055&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22899 Conclusions:The circulating and mucosal innate immunity compartment is phenotypically and functionally altered in pediatric IBD; some alterations may represent a distinctive feature of the pediatric disease condition. The disturbance of NKG2D/ligand pathway may play a role in sustaining immune activation which leads to chronic inflammatory tissue damage. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5649055 Tue, 31 Jan 2012 05:00:00 +0100 5649055 http://www.medworm.com/index.php?rid=5649054&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22898 Conclusions:Clinical parameters at diagnosis are insufficient to predict a disabling course of pediatric CD. More complex models including serological and genetic biomarkers should be tested. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5649054 Tue, 31 Jan 2012 05:00:00 +0100 5649054 http://www.medworm.com/index.php?rid=5649053&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22862 Conclusions:ASCA had the highest diagnostic value among individual anti‐glycan markers. While anti‐chitobioside carbohydrate antibody (ACCA) had the highest association with complications, ASCA and ACCA associated equally with the need for surgery. Although in most individual studies the combination of ≥2 markers had a better diagnostic value as well as higher association with complications and need for surgery, we found the combination performing slightly better than any individual marker in our meta‐analysis. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5649053 Tue, 31 Jan 2012 05:00:00 +0100 5649053 http://www.medworm.com/index.php?rid=5649052&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21943 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5649052 Tue, 31 Jan 2012 05:00:00 +0100 5649052 http://www.medworm.com/index.php?rid=5649051&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21918 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5649051 Tue, 31 Jan 2012 05:00:00 +0100 5649051 http://www.medworm.com/index.php?rid=5649050&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21900 Conclusions:Collagenous colitis has occasionally been reported in patients with organ transplants. It has been reported only once previously in baboons. The four cases reported here strongly suggest that 1) clinical features as well as histopathological findings of collagenous colitis in baboons are very similar to those in human patients; 2) it was associated with the immunocompromised state of the baboons, as two nonimmunosuppressed age‐matched baboons in close proximity did not develop the condition; and 3) it may have had an infectious origin, as all four cases developed within a 4‐week period of time. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5649050 Tue, 31 Jan 2012 05:00:00 +0100 5649050 http://www.medworm.com/index.php?rid=5649049&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22902 Conclusions:Dose intensification leads to a sustained regained response in 47% of CD patients who lost response to standard infliximab dose, but halving the infusion intervals is probably not superior to dose‐doubling. Given the costs and patient inconvenience incurred by an additional infusion visit, the dose‐doubling strategy may be preferable to the interval‐halving strategy. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5649049 Tue, 31 Jan 2012 05:00:00 +0100 5649049 http://www.medworm.com/index.php?rid=5649048&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22892 AbstractAbstract:Mouse models provide powerful tools to investigate disease mechanisms and are widely used in inflammatory bowel disease research. However, it is common for reports of mouse model studies to lack potentially important information about the microbial status of the mice and the method used to evaluate disease expression for statistical analysis. For example, it is common practice to state that the mice were housed under specific pathogen‐free conditions but provide no further information regarding the presence or absence of organisms such as Helicobacter spp. that are known or likely to affect disease expression, thus omitting information potentially important to the expected phenotype of the mice and their responses to experimental manipulation. We therefore encourage auth... Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5649048 Tue, 31 Jan 2012 05:00:00 +0100 5649048 http://www.medworm.com/index.php?rid=5649047&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22891 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5649047 Tue, 31 Jan 2012 05:00:00 +0100 5649047 http://www.medworm.com/index.php?rid=5639033&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22895 Conclusions:CCFA Partners is a novel e‐cohort. Enrollment is ongoing, with surveys twice yearly. CCFA Partners represents a unique resource to study PROs and changes in disease management over time. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5639033 Sun, 29 Jan 2012 21:08:39 +0100 5639033 http://www.medworm.com/index.php?rid=5629748&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22869 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5629748 Thu, 26 Jan 2012 21:26:46 +0100 5629748 http://www.medworm.com/index.php?rid=5629757&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22885 AbstractAbstract: Investigation of the small bowel has been traditionally a challenge for pediatric gastroenterologists due to its location, anatomical tortuosity, and invasiveness of the available techniques. Recently, there has been a remarkable improvement in imaging and endoscopic tools aimed at exploring successfully the small intestine in inflammatory bowel disease. The former are represented by ultrasonography (either alone or with administration of oral contrast agents) and by magnetic resonance: both have provided accurate methods to detect structural bowel changes, diminishing patient discomfort and precluding radiation hazard. The use of traditional radiologic techniques such as fluoroscopy have been markedly reduced due to radiation exposure and inability to depict transmural i... Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5629757 Tue, 24 Jan 2012 05:00:00 +0100 5629757 http://www.medworm.com/index.php?rid=5629756&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22878 Conclusions:These data demonstrate that PKR is a physiologically relevant transducer of inflammatory response signaling in colonic epithelial cells. PKR may promote the homeostasis and survival of intestinal epithelial cells (IECs) through eIF2α‐mediated UPR activation, as well as the activation of STAT3 and AKT pathways. In the absence of PKR, the survival and proliferation of IECs was impaired, thus exacerbating intestinal inflammation. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5629756 Tue, 24 Jan 2012 05:00:00 +0100 5629756 http://www.medworm.com/index.php?rid=5629755&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22871 AbstractUlcerative colitis (UC) and Crohn's disease (CD) may directly result in morbidity and rarely mortality from complications such as colorectal cancer or sepsis. Mortality rates compared with the matched general population, measured by standardized mortality ratio, may therefore be increased. This review examines the evidence derived from cohort‐ and population‐based mortality studies. In CD the majority of studies and two meta‐analyses demonstrated increased standardized mortality ratios of ≈1.5‐fold, especially for those diagnosed at younger ages and requiring extensive or multiple resection surgery. In UC mortality rates are similar to those of the general population in most studies and a meta‐analysis. Proctocolectomy removes the inflammatory burden of UC and can manag... Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5629755 Tue, 24 Jan 2012 05:00:00 +0100 5629755 http://www.medworm.com/index.php?rid=5629754&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21910 Conclusions:RPC may adversely impact urinary function in female patients over time. Bowel frequency, seepage, and pad usage are increased following RPC and function may be worse following VD. RPC does not adversely affect overall sexual function. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5629754 Tue, 24 Jan 2012 05:00:00 +0100 5629754 http://www.medworm.com/index.php?rid=5629753&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21875 Conclusions:FC levels in active disease confined to the small bowel were elevated in the vast majority of children and site of disease was not a confounding factor in this setting. Patients with low FC had a trend toward low levels of inflammatory markers as well. We did not find a significant correlation between FC and clinical indices of activity (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5629753 Tue, 24 Jan 2012 05:00:00 +0100 5629753 http://www.medworm.com/index.php?rid=5629752&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22896 Conclusions:Unlike CRP, fecal calprotectin as an add‐on test after PUCAI or PCDAI facilitates recognition of preclinical relapse. This could help to identify teenagers who require treatment intensification at the time of minimal disease rather than at the time of clinically overt relapse. Further studies are warranted to determine the impact of fecal calprotectin testing on treatment management and outcome. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5629752 Tue, 24 Jan 2012 05:00:00 +0100 5629752 http://www.medworm.com/index.php?rid=5629751&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22894 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5629751 Tue, 24 Jan 2012 05:00:00 +0100 5629751 http://www.medworm.com/index.php?rid=5629750&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22890 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5629750 Tue, 24 Jan 2012 05:00:00 +0100 5629750 http://www.medworm.com/index.php?rid=5629749&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22884 Conclusions:Variants in innate immune genes involved in pattern recognition and autophagy but not the interleukin‐23 signaling pathway influence antimicrobial seroreactivity in CD. In particular, the additive effect of NOD2 3020insC and ATG16L1 T300A suggests a role for autophagy in development of ASCA. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5629749 Tue, 24 Jan 2012 05:00:00 +0100 5629749 http://www.medworm.com/index.php?rid=5620789&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21869 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5620789 Mon, 23 Jan 2012 21:06:55 +0100 5620789 http://www.medworm.com/index.php?rid=5620794&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22889 Conclusions:Patients with IBD have an increased risk of developing PILD. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5620794 Mon, 23 Jan 2012 05:00:00 +0100 5620794 http://www.medworm.com/index.php?rid=5620793&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22886 Conclusions:AMP‐18 facilitates translocation and assembly of multiple proteins into TJs and their association with and subsequent stabilization of the actin filament network. We speculate that improved barrier function induced by AMP‐18 is mediated by enhanced TJ assembly. Thus, AMP‐18 may provide a promising lead to develop agents effective in healing injured colonic epithelium in IBD. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5620793 Mon, 23 Jan 2012 05:00:00 +0100 5620793 http://www.medworm.com/index.php?rid=5620792&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22883 Conclusions:These observations indicate that Trib2 is a novel regulator in the TLR5 signaling pathway and altered expression of Trib2 may play a role in IBD. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5620792 Mon, 23 Jan 2012 05:00:00 +0100 5620792 http://www.medworm.com/index.php?rid=5620791&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22882 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5620791 Mon, 23 Jan 2012 05:00:00 +0100 5620791 http://www.medworm.com/index.php?rid=5620790&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22879 Conclusions:The Mayo score can be accurately predicted from the partial Mayo score. A noninvasive index can replace the Mayo score in future clinical trials. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5620790 Mon, 23 Jan 2012 05:00:00 +0100 5620790 http://www.medworm.com/index.php?rid=5609913&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22897 Conclusions:MRC is feasible and reliable in rats with TNBS‐induced colitis. MRC criteria including colon wall thickness, wall signal intensity on T2w images, hyperintensity in T1w sequence, and the appearance of a target sign pattern may be potential targets for new IBD drugs. (Inflamm Bowel Dis 2012) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5609913 Fri, 20 Jan 2012 21:03:29 +0100 5609913 http://www.medworm.com/index.php?rid=5598654&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22881 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5598654 Tue, 17 Jan 2012 21:59:57 +0100 5598654 http://www.medworm.com/index.php?rid=5583232&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22866 Conclusions:We found no differences of survival with lymphoma between IBD patients and expected survival for the general population. Also, the prognosis for those IBD patients treated with 6‐MP/AZA was not worse than lymphoma patients not treated with 6‐MP/AZA. Statistical analysis, however, was limited by the small sample size and heterogeneity of the patients studied. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5583232 Sat, 14 Jan 2012 06:30:22 +0100 5583232 http://www.medworm.com/index.php?rid=5583238&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22877 AbstractThe World Health Organization has recommended the integrated model of care as the current best practice of care, and, in recent years, it has been gaining popularity worldwide in various settings. However, there have been very few reports on applications of this model to the care of patients with gastrointestinal problems and no reports in the case of inflammatory bowel disease (IBD). However, several IBD centres worldwide have been using the model as part of their standard care. This discussion paper aims to bring together these units' shared experiences with a range of integrated models of care in order to identify common features and provide recommendations on aspirational care for IBD patients. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5583238 Thu, 12 Jan 2012 05:00:00 +0100 5583238 http://www.medworm.com/index.php?rid=5583237&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22876 Conclusions:The number of GalNAc attached in the IgA O‐linked glycans of CD patients was significantly decreased, and strongly correlated with the clinical activity. Alterations of GalNAc attachment in IgA could be useful as a novel diagnostic and prognostic marker of CD. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5583237 Thu, 12 Jan 2012 05:00:00 +0100 5583237 http://www.medworm.com/index.php?rid=5583236&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22874 Conclusions:CMPs significantly suppress the development of inflammation by modulating cytokine balance and microbial environment in colon. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5583236 Thu, 12 Jan 2012 05:00:00 +0100 5583236 http://www.medworm.com/index.php?rid=5583235&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22873 Conclusions:Patients with CD using ADA had lower healthcare costs than patients using IFX; this difference was partly driven by outpatient medical costs. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5583235 Thu, 12 Jan 2012 05:00:00 +0100 5583235 http://www.medworm.com/index.php?rid=5583234&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22872 Conclusions:Elements of study design negatively and positively influence willingness to participate. Invasive procedures, randomization, and frequent visits negatively influenced willingness to participate and as each of these components are added, a significant additive percent of potential subjects are lost. Strategies to further identify barriers to enrollment within IBD study populations should be pursued. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5583234 Thu, 12 Jan 2012 05:00:00 +0100 5583234 http://www.medworm.com/index.php?rid=5583233&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22870 Conclusions:In patients with IBD a VTE event is not only a consequence of their disease, but might also be a marker of occult cancer. We suggest that IBD patients with VTE should follow the same diagnostic work‐up guidelines as non‐IBD VTE patients. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5583233 Thu, 12 Jan 2012 05:00:00 +0100 5583233 http://www.medworm.com/index.php?rid=5583244&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22875 Conclusions:CD triggers the mobilization of MSCs, EPCs, and VSELs, while the significance and precise role of these mobilized cells in repair of damaged intestine requires further study. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5583244 Wed, 11 Jan 2012 05:00:00 +0100 5583244 http://www.medworm.com/index.php?rid=5583243&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22867 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5583243 Wed, 11 Jan 2012 05:00:00 +0100 5583243 http://www.medworm.com/index.php?rid=5583242&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22865 Conclusions:A serum cytokine profile may be an auxiliary tool for the diagnosis and severity assessment of UC. IL‐8 seems to be a reliable biomarker, closely related to disease activity. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5583242 Wed, 11 Jan 2012 05:00:00 +0100 5583242 http://www.medworm.com/index.php?rid=5583241&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22864 Conclusions:Precise clinical, histological, and molecular analyses reveal marked differences between patients with CUC and those with associated AI phenomena, supporting the hypothesis of a distinct AI presentation of IBD. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5583241 Wed, 11 Jan 2012 05:00:00 +0100 5583241 http://www.medworm.com/index.php?rid=5583240&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22861 Conclusions:As a simple and noninvasive marker, FC is useful to predict relapse in quiescent IBD patients. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5583240 Wed, 11 Jan 2012 05:00:00 +0100 5583240 http://www.medworm.com/index.php?rid=5583239&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21895 Conclusions:Cdcs1 modifies the response to H. hepaticus infection. However, this infection alone does not reflect the original response to a complex colitogenic biota. H. hepaticus‐induced inflammation altered intestinal microbiota in a mouse strain‐specific manner. Bacteroides spp. became more abundant in susceptible C3Bir‐Il10−/−, lactobacilli in B6‐Il10−/− mice. Therefore, both host immune response and differential compositional changes of microbiota play a role in strain‐specific colitis susceptibility in Il10−/− mice. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5583239 Wed, 11 Jan 2012 05:00:00 +0100 5583239 http://www.medworm.com/index.php?rid=5583247&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21907 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5583247 Mon, 09 Jan 2012 05:00:00 +0100 5583247 http://www.medworm.com/index.php?rid=5583246&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22843 Conclusions:MRE with enema is a valuable diagnostic tool for assessing inflammation in CD patients. Water enema is well tolerated and significantly improves detection of inflammation in the terminal ileum. Water enema should therefore be included in MRE protocols for CD patients. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5583246 Mon, 09 Jan 2012 05:00:00 +0100 5583246 http://www.medworm.com/index.php?rid=5583245&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21909 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5583245 Mon, 09 Jan 2012 05:00:00 +0100 5583245 http://www.medworm.com/index.php?rid=5561033&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22868 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5561033 Wed, 04 Jan 2012 05:00:00 +0100 5561033 http://www.medworm.com/index.php?rid=5561032&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22863 Conclusions:A normal FC after induction therapy with TNFα antagonists predicts sustained clinical remission in the majority of patients on scheduled therapy with active luminal disease. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5561032 Wed, 04 Jan 2012 05:00:00 +0100 5561032 http://www.medworm.com/index.php?rid=5561031&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22859 AbstractAbstract: In recent years our understanding of the pathogenesis of inflammatory bowel disease (IBD) has greatly increased. Hallmarks of IBD include loss of intestinal barrier function, increased cytokine production, and failed resolution of tissue damage. Lasting treatments are still lacking and, therefore, a better understanding of the underlying molecular mechanisms is necessary to design novel therapeutic approaches. Apart from transcriptional and posttranscriptional regulation of relevant genes, mammals have evolved a complex and efficient series of mechanisms to rapidly modify newly made proteins for the purposes of signaling and adaptation. These posttranslational protein modifications include, among others, phosphorylation, hydroxylation, neddylation, and cytokine cleavage b... Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5561031 Wed, 04 Jan 2012 05:00:00 +0100 5561031 http://www.medworm.com/index.php?rid=5561030&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22858 Conclusions:We developed a murine IBD model featuring antigen‐specific enterocolitis and demonstrate for the first time that gut inflammation induced by an antigen could be abrogated by H. polygyrus infection. Protection was associated with suppressed IL‐17 and IFN‐γ production, induction of Foxp3+ Tregs, and elevated secretion of non‐T‐cell‐derived IL‐10, all of which could be part of the protective processes. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5561030 Wed, 04 Jan 2012 05:00:00 +0100 5561030 http://www.medworm.com/index.php?rid=5561029&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22857 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5561029 Wed, 04 Jan 2012 05:00:00 +0100 5561029 http://www.medworm.com/index.php?rid=5561028&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22856 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5561028 Wed, 04 Jan 2012 05:00:00 +0100 5561028 http://www.medworm.com/index.php?rid=5561027&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22853 Conclusion:Gene expression analysis and causal network modeling in combination showed that aberrant mRNA expression of genes involved in intestinal epithelial permeability for infliximab responders was restored toward levels observed in normal samples. Infliximab nonresponders showed no equivalent restoration in the expression of these genes. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5561027 Wed, 04 Jan 2012 05:00:00 +0100 5561027 http://www.medworm.com/index.php?rid=5561026&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21940 Conclusions:Combination anti‐TNF and thiopurine therapy provides sustained benefit in patients with perianal CD fistula. Early clinical response is associated with subsequent clinical remission. Radiological healing is slower than clinical healing. Radiologically healed fistula tracts maintain healing on infliximab but can recur after cessation of therapy. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5561026 Sun, 01 Jan 2012 05:00:00 +0100 5561026 http://www.medworm.com/index.php?rid=5526043&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21944 AbstractInflammatory bowel diseases (IBDs), like many other chronic diseases, feature multiple cellular stress responses including endoplasmic reticulum (ER) unfolded protein response (UPR). Maintaining protein homeostasis is indispensable for cell survival and, consequently, distinct signaling pathways have evolved to transmit organelle stress. While the ER UPR, aiming to restore ER homeostasis after challenges to ER function, has been extensively studied in the context of chronic diseases, only recently the related mitochondrial UPR (mtUPR), induced by disturbances of mitochondrial proteostasis, has drawn some attention. ER and mitochondria are in close contact and interact physically and functionally. Accumulating data have placed mitochondria at the center of diverse cellular functions... Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5526043 Thu, 22 Dec 2011 09:32:22 +0100 5526043 http://www.medworm.com/index.php?rid=5515936&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21660 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5515936 Mon, 19 Dec 2011 09:21:03 +0100 5515936 http://www.medworm.com/index.php?rid=5505923&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22860 Conclusions:Richness, evenness, and biodiversity of the gut microbiome were remarkably reduced in children with UC compared with healthy controls. Children who did not respond to steroids harbored a microbiome that was even less rich than steroid responders. This study is the first to characterize the gut microbiome in a large cohort of pediatric patients with severe UC and describes changes in the gut microbiome as a potential prognostic feature. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5505923 Fri, 16 Dec 2011 09:30:58 +0100 5505923 http://www.medworm.com/index.php?rid=5515942&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22855 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5515942 Fri, 16 Dec 2011 05:00:00 +0100 5515942 http://www.medworm.com/index.php?rid=5515941&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22854 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5515941 Fri, 16 Dec 2011 05:00:00 +0100 5515941 http://www.medworm.com/index.php?rid=5515940&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22852 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5515940 Fri, 16 Dec 2011 05:00:00 +0100 5515940 http://www.medworm.com/index.php?rid=5515939&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22851 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5515939 Fri, 16 Dec 2011 05:00:00 +0100 5515939 http://www.medworm.com/index.php?rid=5515938&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22850 Conclusion:Our data to date suggest that an integrated model of care for patients with IBD may yield superior long‐term outcomes in terms of medication use and hospitalization rates and reduce healthcare costs. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5515938 Fri, 16 Dec 2011 05:00:00 +0100 5515938 http://www.medworm.com/index.php?rid=5515937&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22842 Conclusions:These findings reveal novel, complex, and dynamic changes in gene expression that may provide useful targets for future therapeutic approaches. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5515937 Fri, 16 Dec 2011 05:00:00 +0100 5515937 http://www.medworm.com/index.php?rid=5495396&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22839 AbstractIn the management of Crohn's disease, earlier aggressive treatment is becoming accepted as a strategy to prevent or retard progression to irreversible bowel damage. It is not yet clear, however, if this same concept should be applied to ulcerative colitis. Hence, we review herein the long‐term structural and functional consequences of this latter disease. Disease progression in ulcerative colitis takes six principal forms: proximal extension, stricturing, pseudopolyposis, dysmotility, anorectal dysfunction, and impaired permeability. The precise incidence of these complications and the ability of earlier, more aggressive treatment to prevent them have yet to be determined. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5495396 Tue, 13 Dec 2011 09:46:58 +0100 5495396 http://www.medworm.com/index.php?rid=5495401&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22849 Conclusions:Our data are in favor of a model in which probiotics downregulate expression of chemokines in the colon, thereby decreasing influx of inflammatory cells and rendering mice resistant to the induction of colitis. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5495401 Sun, 11 Dec 2011 05:00:00 +0100 5495401 http://www.medworm.com/index.php?rid=5495400&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22848 Conclusions:The intestinal microbiota influences colitis severity in Nod1−/−;Nod2−/− mice. The results suggest that colonization strategies with defined commensals or exogenous specific probiotic therapy may prevent intestinal inflammation in a genetically predisposed host. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5495400 Sun, 11 Dec 2011 05:00:00 +0100 5495400 http://www.medworm.com/index.php?rid=5495399&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22847 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5495399 Sun, 11 Dec 2011 05:00:00 +0100 5495399 http://www.medworm.com/index.php?rid=5495398&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22845 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5495398 Sun, 11 Dec 2011 05:00:00 +0100 5495398 http://www.medworm.com/index.php?rid=5495397&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22844 Conclusions:Even if stenting appears an effective technique in treating symptomatic CD intestinal strictures, the procedure is associated with a prohibitively high rate of spontaneous migrations and complications. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5495397 Sun, 11 Dec 2011 05:00:00 +0100 5495397 http://www.medworm.com/index.php?rid=5477277&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21705 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5477277 Tue, 06 Dec 2011 05:00:00 +0100 5477277 http://www.medworm.com/index.php?rid=5477276&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21854 Conclusions:A panel of anti‐glycan antibodies including the novel Anti‐L and Anti‐C may aid in the differentiation of pediatric CD from UC and is associated with complicated CD behavior. The marker accuracy remained constant over time. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5477276 Tue, 06 Dec 2011 05:00:00 +0100 5477276 http://www.medworm.com/index.php?rid=5477275&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21896 Conclusions:Vedolizumab demonstrated dose‐proportional pharmacokinetics and maximally saturated α4β7 receptors over the tested dose range. Multiple dosing up to 10 mg/kg was well tolerated. Over the course of follow‐up a greater proportion of patients treated with vedolizumab were in clinical response than those who were assigned to placebo. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5477275 Tue, 06 Dec 2011 05:00:00 +0100 5477275 http://www.medworm.com/index.php?rid=5477274&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22834 This article addresses important issues of online IBD‐related health information and social media activity, such as quality, reliability, objectivity, and privacy. We reviewed the medical literature on the quality of online information provided to IBD patients, and summarized the most commonly accessed Websites related to IBD. We also assessed the activity on popular social media sites (such as Facebook, Twitter, and YouTube), and evaluated currently available applications for use by IBD patients and providers on mobile phones and tablets. Through our review of the literature and currently available resources, we developed a list of recommended online resources to strengthen patient participation in their care by providing reliable, comprehensive educational material. (Inflamm Bowel Dis ... Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5477274 Tue, 06 Dec 2011 05:00:00 +0100 5477274 http://www.medworm.com/index.php?rid=5477273&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22838 Conclusions:In our study population, cigarette smoking is a risk factor for the development of both forms of microscopic colitis. There were no significant differences between LC and CC, and current smoking and the development of microscopic colitis affected men and women similarly. We feel that these data are sufficient to discuss the potential risks of tobacco use in patients with microscopic colitis. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5477273 Tue, 06 Dec 2011 05:00:00 +0100 5477273 http://www.medworm.com/index.php?rid=5477272&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22841 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5477272 Tue, 06 Dec 2011 05:00:00 +0100 5477272 http://www.medworm.com/index.php?rid=5477278&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21932 Conclusions:About one‐tenth of patients still require colectomy for UC at 5 years in the era of biologics. Oral 5‐ASA, azathioprine, and anti‐TNF therapy are not associated with a reduced need for colectomy. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5477278 Sun, 04 Dec 2011 05:00:00 +0100 5477278 http://www.medworm.com/index.php?rid=5477271&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22840 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5477271 Thu, 01 Dec 2011 05:00:00 +0100 5477271 http://www.medworm.com/index.php?rid=5469625&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22835 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5469625 Thu, 01 Dec 2011 05:00:00 +0100 5469625 http://www.medworm.com/index.php?rid=5458740&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21942 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5458740 Thu, 01 Dec 2011 05:00:00 +0100 5458740 http://www.medworm.com/index.php?rid=5441936&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21923 Conclusions:Patients with NET and CD show similarities in their abnormalities of the fecal biostructure. Interferon alpha and systemic chemotherapy significantly improved the fecal biostructure in patients with midgut NET. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5441936 Fri, 25 Nov 2011 09:25:28 +0100 5441936 http://www.medworm.com/index.php?rid=5441940&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22846 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5441940 Wed, 23 Nov 2011 05:00:00 +0100 5441940 http://www.medworm.com/index.php?rid=5441939&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21941 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5441939 Wed, 23 Nov 2011 05:00:00 +0100 5441939 http://www.medworm.com/index.php?rid=5441938&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21937 Conclusions:Autoantibodies to citrullinated proteins were low in IBD‐related arthritis. These findings suggest that these antibodies are not useful biomarkers in IBD to predict who may develop IBD‐related arthropathy. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5441938 Wed, 23 Nov 2011 05:00:00 +0100 5441938 http://www.medworm.com/index.php?rid=5441937&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21936 Conclusions:Bacterial groups within the expanded phylogenetic gap of pouch patients may have roles in the pathogenesis of pouchitis. Further research concerning the physiology of cultured members of these groups will be necessary to explain their specific roles. Members of the Lachnospiraceae, Incertae Sedis XIV, and clostridial cluster IV could be useful biomarkers of pouch health. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5441937 Wed, 23 Nov 2011 05:00:00 +0100 5441937 http://www.medworm.com/index.php?rid=5441944&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22836 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5441944 Tue, 22 Nov 2011 05:00:00 +0100 5441944 http://www.medworm.com/index.php?rid=5441943&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21878 Conclusions:In Manitoba the direct average annual healthcare cost of CD is greater than UC and that of a patient using infliximab tends to be greater than one incurring a surgical stay. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5441943 Tue, 22 Nov 2011 05:00:00 +0100 5441943 http://www.medworm.com/index.php?rid=5441942&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21637 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5441942 Tue, 22 Nov 2011 05:00:00 +0100 5441942 http://www.medworm.com/index.php?rid=5441941&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21636 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5441941 Tue, 22 Nov 2011 05:00:00 +0100 5441941 http://www.medworm.com/index.php?rid=5423007&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21931 Conclusions:This study not only describes the P2Y6 signaling mechanism regulating CXCL8 expression in IEC, but it also illustrates the potential of targeting P2Y6 to reduce intestinal inflammation. (Inflamm Bowel Dis 2011) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5423007 Sat, 19 Nov 2011 09:48:53 +0100 5423007 http://www.medworm.com/index.php?rid=5409429&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21924 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5409429 Thu, 17 Nov 2011 00:32:30 +0100 5409429 http://www.medworm.com/index.php?rid=5409436&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21938 Conclusions:OD dosing with Asacol 2.4 g is as safe and effective as TDS dosing, and secondary analysis confirmed significantly reduced relapse rates. The benefit, however, was clinically borderline and may relate in part to ease of adherence. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5409436 Sun, 13 Nov 2011 05:00:00 +0100 5409436 http://www.medworm.com/index.php?rid=5409435&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21935 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5409435 Sun, 13 Nov 2011 05:00:00 +0100 5409435 http://www.medworm.com/index.php?rid=5409434&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21934 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5409434 Sun, 13 Nov 2011 05:00:00 +0100 5409434 http://www.medworm.com/index.php?rid=5409433&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21933 Conclusions:Our data suggest that hs‐CRP positivity at diagnosis is associated with disease location and behavior, and in patients who are hs‐CRP positive at diagnosis, is an accurate marker of disease activity and a predictor of short‐ and medium‐term clinical flare‐ups during follow‐up. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5409433 Sun, 13 Nov 2011 05:00:00 +0100 5409433 http://www.medworm.com/index.php?rid=5409432&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21930 Conclusions:These data demonstrate a critical role for matriptase in restoring barrier function to injured intestinal mucosa during colitis, which is suppressed by excessive activation of the immune system. Strategies to enhance matriptase‐mediated barrier recovery could be important for intervening in the cycle of inflammation associated with IBD. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5409432 Sun, 13 Nov 2011 05:00:00 +0100 5409432 http://www.medworm.com/index.php?rid=5409431&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21929 Conclusions:We propose that discontinuation of spironolactone in patients without liver disease during CDI could reduce hospital mortality by 2‐fold, potentially reducing mortality from CDI by 35,000 patients annually across Europe and the U.S. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5409431 Sun, 13 Nov 2011 05:00:00 +0100 5409431 http://www.medworm.com/index.php?rid=5409430&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21928 Conclusions:An early intervention with IFX monotherapy should prevent clinical, serological, and endoscopic CD recurrence following ileocolic resection. Thiopurine naivety and eliminating the initial loading dose of IFX might minimize serious AEs. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5409430 Sun, 13 Nov 2011 05:00:00 +0100 5409430 http://www.medworm.com/index.php?rid=5388526&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21903 AbstractThe diagnosis of inflammatory bowel disease (IBD) is traditionally based on a combination of clinical, endoscopic, histological, and radiological criteria. However, further testing is needed in cases of diagnostic uncertainty and in predicting disease course. This systematic review focuses on the potential for 10 serological antibodies to fill these roles: pANCA, ASCA, anti‐OmpC, anti‐CBir1, anti‐I2, ALCA, ACCA, AMCA, anti‐L, and anti‐C. We discuss their prevalence in IBD and health; their role in disease diagnosis and risk stratification; their stability over time; their presence in unaffected relatives; their association with genetic variants; and differences across ethnic groups. Serological antibodies have some role in primary diagnosis and in differentiating between ... Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5388526 Thu, 10 Nov 2011 10:37:45 +0100 5388526 http://www.medworm.com/index.php?rid=5388531&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.22837 Conclusions:Identifying current treatment patterns may serve to highlight variations in care among this pediatric IBD population. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5388531 Tue, 08 Nov 2011 05:00:00 +0100 5388531 http://www.medworm.com/index.php?rid=5388530&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21927 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5388530 Tue, 08 Nov 2011 05:00:00 +0100 5388530 http://www.medworm.com/index.php?rid=5388529&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21925 Conclusions:A large proportion of IBD patients have mucosal inflammation without clinical symptoms. Although one‐third recover spontaneously, mucosal inflammation in patients who are clinically in remission is associated with more severe mucosal disease activity, but not with more complications or symptomatic flares during follow‐up. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5388529 Tue, 08 Nov 2011 05:00:00 +0100 5388529 http://www.medworm.com/index.php?rid=5388528&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21917 Conclusions:IBD patients undergoing cholecystectomy have a significantly increased risk of postoperative complications. Although further studies are warranted to clarify the reason for these differences, caution should be taken to determine the need and timing of cholecystectomy in IBD patients. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5388528 Tue, 08 Nov 2011 05:00:00 +0100 5388528 http://www.medworm.com/index.php?rid=5388527&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21916 Conclusions:Lean but not fat mass improved at the end of EEN. Median concentrations for several plasma micronutrients improved on EEN but carotenoids were depleted. These findings may have implications for clinical practice and producers of enteral feeds. As plasma concentrations for many micronutrients can be affected by the acute phase response, measurements in erythrocytes may be a better marker of actual body stores. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5388527 Tue, 08 Nov 2011 05:00:00 +0100 5388527 http://www.medworm.com/index.php?rid=5362426&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21914 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5362426 Tue, 01 Nov 2011 04:00:00 +0100 5362426 http://www.medworm.com/index.php?rid=5362431&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21919 Conclusions:AHLC and DA ELISA are equally effective for ATI detection in patients with undetectable serum IFX. AHLC ELISA detects ATI in some patients with detectable serum IFX. This IFX+ATI+ status may be a harbinger of evolving loss of response to the drug. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5362431 Sat, 29 Oct 2011 04:00:00 +0100 5362431 http://www.medworm.com/index.php?rid=5362430&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21915 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5362430 Sat, 29 Oct 2011 04:00:00 +0100 5362430 http://www.medworm.com/index.php?rid=5362429&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21906 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5362429 Sat, 29 Oct 2011 04:00:00 +0100 5362429 http://www.medworm.com/index.php?rid=5362428&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21870 Conclusions:Treatment with TNF antagonists helps preserve the bowel in CD patients. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5362428 Sat, 29 Oct 2011 04:00:00 +0100 5362428 http://www.medworm.com/index.php?rid=5362427&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21738 Conclusions:TLR5 expression on T cells is not required for induction of or protection from T cell‐dependent colitis. Expression of TLR5 in non‐T cells has a pathogenic role, since TLR5 deficiency in recipient mice protects against weight loss induced by WT T cells. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5362427 Sat, 29 Oct 2011 04:00:00 +0100 5362427 http://www.medworm.com/index.php?rid=5348812&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21920 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5348812 Wed, 26 Oct 2011 20:46:05 +0100 5348812 http://www.medworm.com/index.php?rid=5336907&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21831 Conclusions:Further research to identify the most appropriate use of therapeutic drug monitoring is needed. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5336907 Sat, 22 Oct 2011 11:28:25 +0100 5336907 http://www.medworm.com/index.php?rid=5336912&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21913 Conclusions:We identified a novel CD‐associated PTPN2 variant that modulates innate immune responses to bacterial antigens. These findings not only provide key insights into the effects of a functional mutation on a clinically relevant gene, but also reveal how such a mutation could contribute to the onset of disease. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5336912 Fri, 21 Oct 2011 04:00:00 +0100 5336912 http://www.medworm.com/index.php?rid=5336911&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21912 Conclusions:These data provide an important insight into the impact of epigenetic mechanisms in the pathogenesis of CD. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5336911 Fri, 21 Oct 2011 04:00:00 +0100 5336911 http://www.medworm.com/index.php?rid=5336910&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21911 AbstractAbstract: Restorative proctocolectomy with ileal‐pouch anal anastomosis (RPC) is the operation of choice for ulcerative colitis (UC) patients requiring surgery. It is also used for patients with familial adenomatous polyposis (FAP). Pouchitis accounts for 10% of pouch failures. It is an idiopathic inflammatory condition that may occur in up to 50% of patients after RPC for UC. It is rarely seen in FAP patients after RPC. The etiology of pouchitis remains unclear. An overlap with UC is suggested by the frequency with which pouchitis affects patients with UC compared with FAP patients. There is significant clinical evidence implicating bacteria in the pathogenesis of pouchitis. Studies using culture and molecular methods demonstrate a dysbiosis of the pouch microbiota in pouchitis.... Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5336910 Fri, 21 Oct 2011 04:00:00 +0100 5336910 http://www.medworm.com/index.php?rid=5336909&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21908 Conclusions:pStat3 may be a marker for neoplastic transformation in patients with colitis. A shift from predominant immune cell Stat6 activation to Stat3 activation accompanies the onset of dysplasia with concomitant increased epithelial cell Stat3 activation in a subset of patients. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5336909 Fri, 21 Oct 2011 04:00:00 +0100 5336909 http://www.medworm.com/index.php?rid=5336908&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21876 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5336908 Fri, 21 Oct 2011 04:00:00 +0100 5336908 http://www.medworm.com/index.php?rid=5316222&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21926 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5316222 Sat, 15 Oct 2011 09:04:32 +0100 5316222 http://www.medworm.com/index.php?rid=5305118&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21850 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5305118 Wed, 12 Oct 2011 08:41:28 +0100 5305118 http://www.medworm.com/index.php?rid=5316229&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21882 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5316229 Wed, 12 Oct 2011 04:00:00 +0100 5316229 http://www.medworm.com/index.php?rid=5316228&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21884 AbstractAbstract: Although it is clear that inflammatory bowel disease (IBD) involves an inappropriate immune response to floral components, the molecular determinants that mediate the gene transcription underlying and aggravating disease remain poorly understood. There is building momentum, however, that implicates differential regulation of the signal transducer and activator of transcription (STAT) 3 as an important factor in mediating pathogenic gene transcription in IBD, and this notion was reinforced by studies presented at the recent 2011 Digestive Disease Week (DDW) conference in Chicago. In the present report we integrate the existing body of literature with the novel data presented at this meeting to present a kaleidoscopic scheme so as to provide further insight into the role of... Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5316228 Wed, 12 Oct 2011 04:00:00 +0100 5316228 http://www.medworm.com/index.php?rid=5316227&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21887 Conclusions:Taken together, these results confirm MAST3 as a modulator of the inflammatory response through regulation of immune gene expression in the gut of IBD patients. (Inflamm Bowel Dis 2011) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5316227 Wed, 12 Oct 2011 04:00:00 +0100 5316227 http://www.medworm.com/index.php?rid=5316226&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21897 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5316226 Wed, 12 Oct 2011 04:00:00 +0100 5316226 http://www.medworm.com/index.php?rid=5316225&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21898 Conclusions:Together, these data suggest that administration of cAMP‐elevating agents paradoxically decrease infiltration of damage‐causing leukocytes while also preventing epithelial repair and barrier maintenance. We propose that treatment with cAMP‐elevating agents severely limits mucosal reepithelialization and should be contraindicated for use in chronic inflammatory bowel disorders. (Inflamm Bowel Dis 2011) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5316225 Wed, 12 Oct 2011 04:00:00 +0100 5316225 http://www.medworm.com/index.php?rid=5316224&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21899 Conclusions:This is the first study showing the presence of adhesive‐invasive bacteria strains in the inflamed tissues of children with IBD. Collective features of these strains indicate that they belong to the AIEC spectrum, suggesting their possible role in disease pathogenesis. (Inflamm Bowel Dis 2011) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5316224 Wed, 12 Oct 2011 04:00:00 +0100 5316224 http://www.medworm.com/index.php?rid=5316223&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21905 Conclusions:The expression of Th1 and Th17 cytokines varies along the intestine, indicating local specific regulation mechanisms. However, the cytokine expression patterns in the same tissue depends on the pathology, with a Th1 or a Th17 profile in the colon of CD and UC patients, respectively, and a Th1/Th17 profile in the ileum of CD patients. This indicates overlapping but distinct immune mechanisms driving intestinal inflammation in these two pathologies. (Inflamm Bowel Dis 2011) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5316223 Wed, 12 Oct 2011 04:00:00 +0100 5316223 http://www.medworm.com/index.php?rid=5305129&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21894 Conclusions:The deficiency in the colonic butyrate metabolism in UC is initiated at the gene expression level and is the result of a decreased expression of SLC16A1 and enzymes in the β‐oxidation pathway of butyrate. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5305129 Mon, 10 Oct 2011 04:00:00 +0100 5305129 http://www.medworm.com/index.php?rid=5305128&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21891 Conclusions:Our results demonstrate that PTPN2 regulates autophagosome formation in human intestinal cells. We provide a model of how a dysfunction of the CD susceptibility genes, PTPN2 and/or ATG16L1, may contribute to the onset and perpetuation of chronic intestinal inflammation. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5305128 Mon, 10 Oct 2011 04:00:00 +0100 5305128 http://www.medworm.com/index.php?rid=5305127&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21890 Conclusions:CD among Arabs is equally common in males and females, presents at a relatively younger age, and in about half of the patients is limited to the small bowel. These features may indicate an underlying genetic predisposition for the disease in this population, which needs further investigation. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5305127 Mon, 10 Oct 2011 04:00:00 +0100 5305127 http://www.medworm.com/index.php?rid=5305126&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21879 Conclusions:The study has revealed altered expression of syndecan‐1 and ‐4 and HS epitopes in the gut of mice with an IBD‐like gut disorder. The IL10−/− mouse is a useful model for further study of the functional role of HSPGs in chronic inflammation and in maintaining healthy gut barrier. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5305126 Mon, 10 Oct 2011 04:00:00 +0100 5305126 http://www.medworm.com/index.php?rid=5305125&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21730 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5305125 Mon, 10 Oct 2011 04:00:00 +0100 5305125 http://www.medworm.com/index.php?rid=5305124&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21893 Conclusions:Tissue‐specific factors manipulate immunity via modulating characteristics of DC and may provide tools to generate tissue‐specific immunotherapy. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5305124 Mon, 10 Oct 2011 04:00:00 +0100 5305124 http://www.medworm.com/index.php?rid=5305123&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21889 Conclusions:Overall, our data point out the presence of biological differences between blood mononuclear cells from patients with CD and UC toward cigarette smoke that might support its opposite role in both diseases. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5305123 Mon, 10 Oct 2011 04:00:00 +0100 5305123 http://www.medworm.com/index.php?rid=5305122&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21888 Conclusions:The majority of patients preferred anti‐TNF medications that were administered by subcutaneous injection rather than by intravenous infusion. Ease of use and time required for therapy were two major factors influencing the patients' selection of a specific anti‐TNF drug. Patients' individual preferences should be taken into account when prescribing anti‐TNF drugs. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5305122 Mon, 10 Oct 2011 04:00:00 +0100 5305122 http://www.medworm.com/index.php?rid=5305121&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21886 Conclusions:A treatment strategy with an option of shortening the dosing interval of infliximab retrieves its trough level and may be useful for maintaining its efficacy. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5305121 Mon, 10 Oct 2011 04:00:00 +0100 5305121 http://www.medworm.com/index.php?rid=5305120&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21877 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5305120 Mon, 10 Oct 2011 04:00:00 +0100 5305120 http://www.medworm.com/index.php?rid=5305119&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21874 Conclusions:As detected by HOMIM, we found a significant decrease in overall diversity in the oral microbiome of pediatric CD. Considering the proposed microbe–host interaction in IBD, the ease of visualization and direct oral mucosal sampling of the oral cavity, further study of the oral microbiome in IBD is of potential diagnostic and prognostic value. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5305119 Mon, 10 Oct 2011 04:00:00 +0100 5305119 http://www.medworm.com/index.php?rid=5286509&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21922 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5286509 Sat, 01 Oct 2011 04:00:00 +0100 5286509 http://www.medworm.com/index.php?rid=5261615&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21723 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5261615 Thu, 29 Sep 2011 08:29:17 +0100 5261615 http://www.medworm.com/index.php?rid=5261620&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21892 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5261620 Mon, 26 Sep 2011 04:00:00 +0100 5261620 http://www.medworm.com/index.php?rid=5261619&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21881 (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5261619 Mon, 26 Sep 2011 04:00:00 +0100 5261619 http://www.medworm.com/index.php?rid=5261618&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21873 Conclusions:Our results suggest that the drugs based on the structure of SA have the potential to become valuable antiinflammatory or analgesic therapeutics for the treatment of GI diseases. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5261618 Mon, 26 Sep 2011 04:00:00 +0100 5261618 http://www.medworm.com/index.php?rid=5261617&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21867 Conclusions:Imiquimod induces type I IFN and AMP to ameliorate DSS‐induced acute colitis and prevents Salmonella survival. Therefore, Imiquimod treatments provide a new therapeutic approach for IBD patients. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5261617 Mon, 26 Sep 2011 04:00:00 +0100 5261617 http://www.medworm.com/index.php?rid=5261616&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21824 Conclusions:The rate of screening for both latent TB and hepatitis B in this study was inadequate. While the rate of screening is increasing, further systems improvements and physician education is needed. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5261616 Mon, 26 Sep 2011 04:00:00 +0100 5261616 http://www.medworm.com/index.php?rid=5238872&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21818 Conclusions:These data show that regulatory macrophages may be involved in mucosal healing and provide a rationale for the superiority of infliximab/azathioprine combination treatment observed in the clinic. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5238872 Thu, 22 Sep 2011 10:21:21 +0100 5238872 http://www.medworm.com/index.php?rid=5238878&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21872 Conclusions:Women with CD do not have severe ovarian reserve alterations compared to a control population. However, age ≥30 years and a colonic location of the disease could be associated with an accelerated loss of follicles. These data could encourage gastroenterologists to inform CD women of the risk of delaying childbirth. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases) Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5238878 Tue, 20 Sep 2011 04:00:00 +0100 5238878 http://www.medworm.com/index.php?rid=5238877&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21871 AbstractInfliximab, adalimumab, and certolizumab are monoclonal antibodies against tumor necrosis factor‐α (TNFα), a proinflammatory cytokine with an increased expression in the inflamed tissues of inflammatory bowel disease (IBD) patients. Currently, infliximab is the only anti‐TNF drug that has been approved for use in refractory pediatric Crohn's disease (CD). Nevertheless, adalimumab and certolizumab have been used off‐label to treat refractory pediatric IBD. Over the past 10 years, anti‐TNF treatment has been of great benefit to many pediatric IBD patients, but their use is not without risks (infections, autoimmune diseases, malignancies). Despite the growing experience with these drugs in children with IBD, optimal treatment strategies still need to be determined. The purpo... Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5238877 Tue, 20 Sep 2011 04:00:00 +0100 5238877 http://www.medworm.com/index.php?rid=5238876&cid=s_36804_17_f&fid=36804&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fibd.21868 AbstractThe success of genetic analyses identifying multiple loci associated with inflammatory bowel disease (IBD) susceptibility has resulted in the identification of several risk genes linked to a common cellular process called autophagy. Autophagy is a process involving the encapsulation of cytosolic cellular components in double‐membrane vesicles, their subsequent lysosomal degradation, and recycling of the degraded components for use by the cell. It plays an important part in the innate immune response to a variety of intracellular pathogens, and it is this component of autophagy that appears to be defective in IBD. This has lead to the hypothesis that Crohn's disease may result from an impaired antibacterial response, which leads to ineffective control of bacterial infection, dysbi... Inflammatory Bowel Diseases journals http://www.medworm.com/rss/comments.php?id=5238876 Tue, 20 Sep 2011 04:00:00 +0100 5238876