MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Internal Medicine Journal' source. Thu, 09 Feb 2012 09:15:09 +0100 http://www.medworm.com/index.php?rid=5654499&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2012.02723.x AbstractSleep disturbance during menopause is a common and important complaint faced by many women. There are many factors that may play a role in this problem including vasomotor symptoms and changing hormone levels, circadian rhythm abnormalities, exacerbation of primary insomnia, mood disorders, co‐existent medical conditions, as well as lifestyle factors. Sleep can be measured both objectively and subjectively, however correlation between the two measures is not high. Most of the menopause‐related sleep disturbances have been reported as qualitative in nature, however there have also been studies showing changes in objective measures. This discrepancy has implications with regards to evaluation of research in sleep and menopause as well as application in the clinical setting. Inves... Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5654499 Tue, 31 Jan 2012 05:00:00 +0100 5654499 http://www.medworm.com/index.php?rid=5654498&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2012.02724.x Conclusions:  Almost 1 in 2 patients with IDA were not documented as undergoing GI endoscopy. More intense guideline promulgation, improved endoscopy access and ongoing practice audits are required to improve endoscopy rates. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5654498 Tue, 31 Jan 2012 05:00:00 +0100 5654498 http://www.medworm.com/index.php?rid=5654497&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2012.02725.x Conclusion:  RHD has a major impact on maternal cardiac outcomes. However, with current management practices maternal and fetal mortality are low, and the incidence of complications is predictable based on known risk factors. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5654497 Tue, 31 Jan 2012 05:00:00 +0100 5654497 http://www.medworm.com/index.php?rid=5654496&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2012.02726.x Conclusions:  Methylnatrexone has a positive impact on symptoms in women with NBS, although treatment does induce transient pain following its administration. Larger studies are required to examine its efficacy and longer term safety in this patient group. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5654496 Tue, 31 Jan 2012 05:00:00 +0100 5654496 http://www.medworm.com/index.php?rid=5654495&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2012.02727.x CONCLUSIONS:  Within a period of 14 years median life‐expectancy of patients with RA with disease onset in the early 1990s is reduced by 6 to 7 years. However, our results also suggest a secular reduction in excess mortality. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5654495 Sun, 01 Jan 2012 05:00:00 +0100 5654495 http://www.medworm.com/index.php?rid=5633669&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02635.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5633669 Sun, 01 Jan 2012 05:00:00 +0100 5633669 http://www.medworm.com/index.php?rid=5633668&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02592.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5633668 Sun, 01 Jan 2012 05:00:00 +0100 5633668 http://www.medworm.com/index.php?rid=5633667&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02615.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5633667 Sun, 01 Jan 2012 05:00:00 +0100 5633667 http://www.medworm.com/index.php?rid=5633666&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02607.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5633666 Sun, 01 Jan 2012 05:00:00 +0100 5633666 http://www.medworm.com/index.php?rid=5633665&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02632.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5633665 Sun, 01 Jan 2012 05:00:00 +0100 5633665 http://www.medworm.com/index.php?rid=5633664&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02633.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5633664 Sun, 01 Jan 2012 05:00:00 +0100 5633664 http://www.medworm.com/index.php?rid=5633663&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02634.x Aged care health professionals in Australia are increasingly referred patients whose standard of cleanliness and self‐care has deteriorated to levels resulting in public health concern. This paper describes three illustrative case studies of people referred to an Australian Aged Care Assessment Service who present with ‘Diogenes Syndrome’. The diversity and complexity of these cases reflect variable underlying diagnoses. Symptoms of self‐neglect, hoarding and domestic squalor and combinations thereof may provide a more useful classification system of the older person who presents in such circumstances than the frequently used term Diogenes syndrome. Practical guidelines are required for appropriate assessment and management of these conditions. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5633663 Sun, 01 Jan 2012 05:00:00 +0100 5633663 http://www.medworm.com/index.php?rid=5633662&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02591.x This report highlights the importance of recognising atypical HUS in SLE patients by looking for schistocytes in case of haemolytic anemia with a negative antiglobulin test, in order to begin plasma exchange. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5633662 Sun, 01 Jan 2012 05:00:00 +0100 5633662 http://www.medworm.com/index.php?rid=5633661&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2010.02238.x Conclusion: Childhood asthma emerged with the strongest association for GOLD‐defined COPD. Possible explanations for this are suggested, including limitations of the current GOLD spirometric definition of COPD, a chance observation because of the high prevalence of both disorders in this population, or alternatively childhood asthma is a risk factor for COPD. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5633661 Sun, 01 Jan 2012 05:00:00 +0100 5633661 http://www.medworm.com/index.php?rid=5633660&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2010.02284.x Conclusion:  Our findings show that the dissemination of web‐based treatment protocols does not guarantee widespread use. Organisational, environmental and clinician‐specific factors play a role in uptake and utilisation. The deployment of sufficient computer infrastructure, implementation of targeted training programmes and hospital policies and investment in marketing approaches are fundamental to uptake and continued use. This study highlights the value of ongoing monitoring and evaluation to ensure systems like eviQ achieve their primary purpose – reducing treatment variation and improving quality of care. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5633660 Sun, 01 Jan 2012 05:00:00 +0100 5633660 http://www.medworm.com/index.php?rid=5633659&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02538.x Conclusions:  This study indicates that patients with chronic renal failure who are maintained on HD exhibit an increased prevalence of SCI, and that MCP‐1 is significantly associated with the presence of SCI in HD patients. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5633659 Sun, 01 Jan 2012 05:00:00 +0100 5633659 http://www.medworm.com/index.php?rid=5633658&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02459.x Conclusion:  A standardised loading dose is a simple and sustainable intervention that may improve early achievement of therapeutic vancomycin levels in critically ill patients. The clinical significance of this requires further study. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5633658 Sun, 01 Jan 2012 05:00:00 +0100 5633658 http://www.medworm.com/index.php?rid=5633657&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02606.x AbstractCardiac magnetic resonance imaging (CMR) has matured into a robust, accurate and highly reproducible imaging modality for the assessment of cardiac function and ischaemic heart disease. The unique physical properties of CMR permit depiction of pathology‐specific tissue contrast based on differences in tissue composition, such as myocardial oedema, necrosis and fibrosis. This can be imaged at high spatial resolution allowing characterisation of the acuity of an ischaemic event, the presence and extent of myocardial ischaemia, necrosis and viability. Prognostically important information obtained from CMR evaluation of ischaemic heart disease, such as left ventricular ejection fraction, infarct size and transmurality, infarct location and the presence of intraventricular mechanical ... Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5633657 Sun, 01 Jan 2012 05:00:00 +0100 5633657 http://www.medworm.com/index.php?rid=5633656&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02631.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5633656 Sun, 01 Jan 2012 05:00:00 +0100 5633656 http://www.medworm.com/index.php?rid=5633655&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02650_1.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5633655 Sun, 01 Jan 2012 05:00:00 +0100 5633655 http://www.medworm.com/index.php?rid=5633654&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02650.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5633654 Sun, 01 Jan 2012 05:00:00 +0100 5633654 http://www.medworm.com/index.php?rid=5556004&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02705.x AbstractThis review examines the environmental and genetic contributions to the ANCA‐associated systemic vasculitides. The dominant environmental risk factors appear to be silica exposure for all three syndromes and vitamin D deficiency is strongly suggested by the latitude and UV radiation gradient observed for Wegener's granulomatosis and Churg‐Strauss syndrome. Genetic factors are generally not very strong, consistent with the rarity of these conditions in children. However, multiple genetic factors each with a relatively small effect may combine to create a stae of susceptibility towards autoimmunity. With infection as a triggering agent it is possible to synthesize a pathogenetic hypothesis which accounts for both environmental and genetic effects in regard to both necrotising vas... Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5556004 Thu, 29 Dec 2011 05:00:00 +0100 5556004 http://www.medworm.com/index.php?rid=5556003&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02706.x AbstractWe review the aetiology of scleroderma from an epidemiological perspective examining genetic, environmental and stochastic risk factors. The presence of familial clustering (but with low twin concordance) suggests a genetic contribution and this has been confirmed with recent candidate gene and genome wide association screening demonstrating both MHC and non‐MHC genetic linkage. In contrast environmental associations are weak or inconsistent. An examination of the age adjusted incidence curve of scleroderma is consistent with a stochastic process involving 5‐8 random events.In pathogenesis, scleroderma is best considered as an autoimmune disorder where genetic and environmental factors are both important variables, but random events are also likely to play a pivotal role. We su... Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5556003 Thu, 29 Dec 2011 05:00:00 +0100 5556003 http://www.medworm.com/index.php?rid=5556002&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02707.x Conclusions:  In lesions <2cm, CT‐guided biopsy had higher yields however EBUS GS had better tolerability and fewer complications. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5556002 Thu, 29 Dec 2011 05:00:00 +0100 5556002 http://www.medworm.com/index.php?rid=5556001&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02708.x Conclusions:  CHD associated with PAH in adult life has resulted in a new population with unique needs. This registry will allow documentation of clinical course and long‐term outcomes for these patients. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5556001 Thu, 29 Dec 2011 05:00:00 +0100 5556001 http://www.medworm.com/index.php?rid=5555999&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02709.x Conclusion:  Our study showed that “Code Stroke” rapid access protocol decreased Door‐to‐Needle Time and possibly contributed to the increased IV‐tPA usage. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5555999 Thu, 29 Dec 2011 05:00:00 +0100 5555999 http://www.medworm.com/index.php?rid=5555998&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02710.x Conclusions:  This is the first long‐term follow‐up study of ICD patients in New Zealand. We observed a low mortality rate when compared to other published registries, but a similar rate of both appropriate and inappropriate shock therapy. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5555998 Thu, 29 Dec 2011 05:00:00 +0100 5555998 http://www.medworm.com/index.php?rid=5555997&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02711.x Conclusion:  This study highlights increasing burden of CHB in Western Australia, from people born in endemic countries, in particular the direct costs of treatment. It will help to develop strategies that can be tailored to Western Australia with appropriate allocation of resources. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5555997 Thu, 29 Dec 2011 05:00:00 +0100 5555997 http://www.medworm.com/index.php?rid=5531090&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02683.x Conclusions  Australasian thoracic physicians prefer EBUS‐TBNA for the mediastinal staging of NSCLC but access to EBUS‐TBNA services is limited. We recommend targeted measures to improve access to EBUS‐TBNA use and optimise mediastinal staging of NSCLC. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5531090 Wed, 21 Dec 2011 05:00:00 +0100 5531090 http://www.medworm.com/index.php?rid=5531089&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02684.x Conclusion:  ADE‐related ED visits are not uncommon in Taiwan and many cases are preventable. ED‐based surveillance may provide useful information for monitoring outpatient ADE. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5531089 Wed, 21 Dec 2011 05:00:00 +0100 5531089 http://www.medworm.com/index.php?rid=5531091&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02644.x Conclusion:  NAFLD was independently associated with reduced pulmonary function, and the severity of NAFLD was inversely correlated with the decrease in lung function. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5531091 Tue, 20 Dec 2011 05:00:00 +0100 5531091 http://www.medworm.com/index.php?rid=5491356&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02638.x ABSTRACTMortality related to induction chemotherapy during the treatment of acute leukaemias (AL) has been estimated at 5‐20%, and this increases with age. Fungal infection remains one of the major causes of morbidity and mortality and is considered an obstacle to the successful management of acute leukaemias.We retrospectively analysed all patients treated for acute leukaemias at a single institution between July 2006 and January 2009, to assess the impact of early antifungal therapy on outcome during induction chemotherapy. There were 44 episodes of induction chemotherapy, with a median age of patients of 61 years (range 18‐81), including 29 patients with acute myeloid leukaemia, 9 with acute lymphoblastic leukaemia, and 6 with relapsed AL. The median age was 61 years (range 18‐81)... Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5491356 Thu, 08 Dec 2011 05:00:00 +0100 5491356 http://www.medworm.com/index.php?rid=5491355&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02639.x Conclusion:  To build a predictive model to identify injured workers at risk of a prolonged RTW outcome at the time of workers compensation claim lodgement in Australia it is necessary to redesign the workers compensation claim lodgement questionnaires; improve data management, and utilise specific analytic techniques. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5491355 Thu, 08 Dec 2011 05:00:00 +0100 5491355 http://www.medworm.com/index.php?rid=5491354&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02640.x Conclusion  Patients hospitalized on a General Internal Medicine ward are exposed to three times more ionizing radiation than the general population. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5491354 Thu, 08 Dec 2011 05:00:00 +0100 5491354 http://www.medworm.com/index.php?rid=5491353&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02641.x Conclusion:  Patients and health care professionals believe information around illness course, future goals and treatment is important to care. An expanded view of hope may assist when providing such information including when discussing goals of carein the setting of advanced illness. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5491353 Thu, 08 Dec 2011 05:00:00 +0100 5491353 http://www.medworm.com/index.php?rid=5491352&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02642.x Conclusion Since a history of thiazide‐induced hyponatraemia is associated with osteoporotic fracture in univariate but not multivariate analyses, an alternative explanation is that confounding factors of older age and low body mass index accounted for the apparently increased risk of osteoporotic fracture in patients with thiazide‐induced hyponatraemia. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5491352 Thu, 08 Dec 2011 05:00:00 +0100 5491352 http://www.medworm.com/index.php?rid=5491351&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02643.x Conclusions  In haematology patients presenting with febrile neutropenia and pulmonary infiltrate, bronchoscopy is a safe procedure which plays a significant role in management. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5491351 Thu, 08 Dec 2011 05:00:00 +0100 5491351 http://www.medworm.com/index.php?rid=5491350&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02645.x Conclusion.  Aortic stiffness was found to predict cognitive decline in both qualitative review and quantitative analysis. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5491350 Thu, 08 Dec 2011 05:00:00 +0100 5491350 http://www.medworm.com/index.php?rid=5491349&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02646.x Conclusions.  Awareness regarding VTE risk factors and the degree of diagnostic skills among Mexican internal medicine specialists is low. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5491349 Thu, 08 Dec 2011 05:00:00 +0100 5491349 http://www.medworm.com/index.php?rid=5491348&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02647.x Conclusion:  Substantial hurdles identified by participants include cultural differences, language difficulties, cultural beliefs, stigma and misinformation. These data demonstrate the need for the greater dissemination of information in culturally and linguistically appropriate mediums to raise awareness about viral hepatitis, pathogenesis and available treatments. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5491348 Thu, 08 Dec 2011 05:00:00 +0100 5491348 http://www.medworm.com/index.php?rid=5555996&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02712.x Conclusion:  Intragam 10 NF was well tolerated and exhibited similar pharmacokinetics to Intragam P, with the advantage of a 45 minute shorter infusion time. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5555996 Thu, 01 Dec 2011 05:00:00 +0100 5555996 http://www.medworm.com/index.php?rid=5531088&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02686.x Over the last 33 years, mystery has surrounded the diagnosis and treatment of a very influential Australian patient. In the long gap between amputation of his leg for osteogenic sarcoma and successful treatment for widespread tuberculosis, he was told he had advanced and incurable metastatic sarcoma. Details of his recovery and the treatments used have been extensively described. An alternative hypothesis is advanced to explain his recovery. This hypothesis is advanced for two reasons. The first is to underline the modern recognition of the need to consider diagnostic investigations, including biopsy, before assigning the diagnosis of advanced cancer to any patient. This principle is especially vital in cases where two diseases can present in the same way. . The second is that there a risk... Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5531088 Thu, 01 Dec 2011 05:00:00 +0100 5531088 http://www.medworm.com/index.php?rid=5491363&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02608.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5491363 Thu, 01 Dec 2011 05:00:00 +0100 5491363 http://www.medworm.com/index.php?rid=5491362&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02611.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5491362 Thu, 01 Dec 2011 05:00:00 +0100 5491362 http://www.medworm.com/index.php?rid=5491361&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02556.x AbstractThis paper documents the development of cardiac pacing in New Zealand in the early years following the first implant in 1961. This period covered the time of the early development and evolution of cardiac pacemakers. Pacemaker implantations were infrequent and high risk in desperately ill patients. Whilst lifesaving the pacemakers had poor longevity, were unreliable and required frequent revisions. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5491361 Thu, 01 Dec 2011 05:00:00 +0100 5491361 http://www.medworm.com/index.php?rid=5491360&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02593.x We describe these cases and summarize the literature on abdominal LAM. Menstrual cycle variation should be taken into account when assessing response to therapy, both clinically and in research studies. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5491360 Thu, 01 Dec 2011 05:00:00 +0100 5491360 http://www.medworm.com/index.php?rid=5491359&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2010.02226.x Conclusions: Diabetes significantly increases the risk of major cardiovascular events, especially peripheral vascular events in patients with advanced CKD. Trials of multifactorial management of cardiovascular risk factors are required to determine if outcomes for this population may be improved. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5491359 Thu, 01 Dec 2011 05:00:00 +0100 5491359 http://www.medworm.com/index.php?rid=5491358&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2009.02142.x Conclusions: EBUS‐TBNA is able to confirm accurately histologically a large number of disease processes, both malignant and benign, in all clinical indications studied. The procedure is safe even when carried out by proceduralists with minimal prior experience. Diagnostic performance continues to improve beyond 50 cases carried out. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5491358 Thu, 01 Dec 2011 05:00:00 +0100 5491358 http://www.medworm.com/index.php?rid=5491357&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02617.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5491357 Thu, 01 Dec 2011 05:00:00 +0100 5491357 http://www.medworm.com/index.php?rid=5491347&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02648.x Conclusions:  Patients with hypereosinophilia of uncertain aetiology can be empirically managed according to working diagnoses derived from history‐taking, examination and selective investigations. Most patients have benign short‐term outcomes, but longer monitoring is required to assess long‐term outcomes from untreated hypereosinophilia. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5491347 Thu, 01 Dec 2011 05:00:00 +0100 5491347 http://www.medworm.com/index.php?rid=5481593&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02637.x Conclusion:  This study shows aprepitant in combination with palonosetron and dexamethasone is safe and effectively controls CINV in patients undergoing 3‐day cisplatin‐based chemotherapy, moreover, the efficacy is maintained during multiple cycles. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5481593 Tue, 01 Nov 2011 04:00:00 +0100 5481593 http://www.medworm.com/index.php?rid=5415324&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02595.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5415324 Tue, 01 Nov 2011 04:00:00 +0100 5415324 http://www.medworm.com/index.php?rid=5415323&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02618.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5415323 Tue, 01 Nov 2011 04:00:00 +0100 5415323 http://www.medworm.com/index.php?rid=5415322&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02559.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5415322 Tue, 01 Nov 2011 04:00:00 +0100 5415322 http://www.medworm.com/index.php?rid=5415321&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02578.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5415321 Tue, 01 Nov 2011 04:00:00 +0100 5415321 http://www.medworm.com/index.php?rid=5415320&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02589.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5415320 Tue, 01 Nov 2011 04:00:00 +0100 5415320 http://www.medworm.com/index.php?rid=5415319&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02594.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5415319 Tue, 01 Nov 2011 04:00:00 +0100 5415319 http://www.medworm.com/index.php?rid=5415318&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02580.x AbstractThe use of anticoagulant therapy in prosthetic valve endocarditis is a controversial management issue. Some authorities believe that anticoagulation increases the potential risk of cerebral haemorrhage after a thromboembolism whereas others, however, affirm that cessation of anticoagulation itself increases the risk of thromboembolism and subsequent morbidity and mortality. We reviewed the association of anticoagulant therapy and cerebral complications in patients with prosthetic valve endocarditis. Our results suggest that anticoagulant therapy reduces the risk of thromboembolism and is not associated with increased risk of intracranial haemorrhage. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5415318 Tue, 01 Nov 2011 04:00:00 +0100 5415318 http://www.medworm.com/index.php?rid=5415317&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2010.02285.x Conclusion: A multidisciplinary approach is a useful strategy for initiating and sustaining a CAS programme. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5415317 Tue, 01 Nov 2011 04:00:00 +0100 5415317 http://www.medworm.com/index.php?rid=5415316&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02590.x AbstractBoth chronic kidney disease (CKD) and end‐stage renal disease are strongly age related. Although the morbidity and mortality of CKD have significantly improved in recent years because of a greater understanding of its pathophysiology and evidence‐based approach to management, the application of this evidence to the elderly CKD patients is often fraught with difficulty. This is because, besides age, the clinical and biological variables that are widely prevalent in the elderly, such as multiple co‐morbidities, functional impairments and polypharmacy, and quality of life and functional outcome measures, which are pertinent to this age group, have generally not been incorporated into the available evidence. This paper reviews the current evidence with a view to providing a frame... Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5415316 Tue, 01 Nov 2011 04:00:00 +0100 5415316 http://www.medworm.com/index.php?rid=5415315&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02588.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5415315 Tue, 01 Nov 2011 04:00:00 +0100 5415315 http://www.medworm.com/index.php?rid=5371885&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02619.x Conclusions: In New Zealand and Australia, MDS is a common haematological neoplasm. The marked difference between male and female incidence rates, especially with advancing age, may provide insights into the causes of this disease. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5371885 Thu, 27 Oct 2011 04:00:00 +0100 5371885 http://www.medworm.com/index.php?rid=5371884&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02620.x Conclusions:  Higher serum total bilirubin levels were associated with lower likelihood of functional dependence in older adults. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5371884 Thu, 27 Oct 2011 04:00:00 +0100 5371884 http://www.medworm.com/index.php?rid=5371883&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02621.x Conclusions:  anti‐GBM disease is a rare condition, which is not over‐represented among indigenous people. With aggressive therapy the prognosis has improved, however, the morbidity and mortality of this condition remains significant. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5371883 Thu, 27 Oct 2011 04:00:00 +0100 5371883 http://www.medworm.com/index.php?rid=5371882&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02622.x Conclusion  In a sample of healthy older people, statin use was not associated with muscle weakness, postural sway, reduced mobility or falls. Statin users, however, had poorer leaning balance which may potentially increase fall risk in this group. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5371882 Thu, 27 Oct 2011 04:00:00 +0100 5371882 http://www.medworm.com/index.php?rid=5371881&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02623.x Conclusion:  CSA‐CSR is reduced to a greater extent by ASV than oxygen therapy over 8 weeks but was not accepted long‐term. Neither treatment improved prognostic indices of heart failure or symptoms in the short term. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5371881 Thu, 27 Oct 2011 04:00:00 +0100 5371881 http://www.medworm.com/index.php?rid=5371880&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02624.x Conclusion:  A multidisciplinary clinic can provide efficient diagnosis and rapid triage to PAH‐specific therapy, if appropriate. Retention rates remain high, at follow‐up. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5371880 Thu, 27 Oct 2011 04:00:00 +0100 5371880 http://www.medworm.com/index.php?rid=5371879&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02625.x AbstractWhile research investigating direct‐to‐consumer advertising (DtCA) of therapeutic goods in Australia has historically focused on prescription medicines, recent action taken by regulators against companies promoting medical devices has placed the industry into the spotlight. Despite the need to effectively regulate DtCA of medical devices due to its potential harms, inadequacies in the current regulatory system have been noted. Under the present system, devices with a questionable evidence base may enter the Australian marketplace without an evaluation of their effectiveness, and regulators are reliant upon industry self‐regulation and consumer complaints to draw attention to cases of advertising misconduct. Although some successes in the present system have been observed, we ... Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5371879 Thu, 27 Oct 2011 04:00:00 +0100 5371879 http://www.medworm.com/index.php?rid=5371878&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02626.x Conclusions: Conventional therapy is ineffective for symptomatic Blastocystis infection. The high prevalence of Blastocystis infection within households suggested transmission between humans and their pets. Sub‐typing analysis of SSU rDNA alone in Blastocystis does not appear to predict pathogenicity. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5371878 Thu, 27 Oct 2011 04:00:00 +0100 5371878 http://www.medworm.com/index.php?rid=5371877&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02627.x Conclusions.  Our data show that elevated blood cadmium levels are associated with elevated mortality, that there seem to be gender differences in temporal trends of cadmium exposure and that blood cadmium is a proxy of chronic cadmium exposure. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5371877 Thu, 27 Oct 2011 04:00:00 +0100 5371877 http://www.medworm.com/index.php?rid=5371876&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02628.x AbstractImprovements in Aboriginal health have been slow. Research demonstrates ongoing discrimination towards Aboriginal Australians based on race, including in health services, leads to poor health outcomes. Using an eclectic methodology based on observations and discussions with health practitioners experienced in working with Aboriginal patients, this paper identifies how cross‐cultural misunderstandings undermine the quality of care to Aboriginal patients in hospital and offers suggestions for improving practice. It also explores the concept of institutional racism and challenges doctors to reflect on their role in perpetuating power imbalances. We argue that physicians and health care providers need to do more than just deliver evidence‐based interventions, by critically reflecti... Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5371876 Thu, 27 Oct 2011 04:00:00 +0100 5371876 http://www.medworm.com/index.php?rid=5371875&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02629.x Conclusions:  LT of Ph chromosome‐negative MPD is rare and uniformly fatal. Despite chemotherapy, survival was poor and patients succumbed to refractory disease and infections. Asian patients did not have a more favorable outcome. It remains to be investigated whether upfront stem cell transplant may be a treatment option. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5371875 Thu, 27 Oct 2011 04:00:00 +0100 5371875 http://www.medworm.com/index.php?rid=5320012&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02605.x Conclusion:  There are high prevalence rates of risk factors for foot ulceration in the ESRD population on haemodialysis and are comparable to those with DM. Individuals with coexisting ESRD and DM have an even greater risk for foot ulceration and LEA. This highlights the importance that regular foot screening, preventative education and treatment are necessary for patients with ESRD to potentially reduce the risk of foot ulcerations and LEAs. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5320012 Fri, 14 Oct 2011 04:00:00 +0100 5320012 http://www.medworm.com/index.php?rid=5309371&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02607.x We report a 36 year old woman who experienced a severe febrile illness following clozapine administration with associated organ dysfuntion. No microbiological cause for the illness was defined and we postulate that this illness represents a form of clozapine toxicity. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5309371 Wed, 12 Oct 2011 04:00:00 +0100 5309371 http://www.medworm.com/index.php?rid=5309370&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02608.x AbstractA 54‐year old female immigrant underwent coronary angiography for chest pain. There was no coronary artery disease, but dilatation of left ventricular (LV) apex was seen on ventriculography. Cardiovascular magnetic resonance (CMR) was performed to further define the LV apex.CMR revealed an apical LV aneurysm, with transmural fibrosis of the entire LV apex Sub‐epicardial enhancement was also present in the basal inferolateral and mid‐septal walls. These findings in the patient from Ecuador were suspicious of Chagas’ disease. Serological antibody (IgG) confirmed infection with Trypanosoma cruzi.Cardiac involvement is a determining factor of prognosis in Chagas disease. CMR is more sensitive for detection of myocardial involvement than echocardiography.Physicians in Australia ... Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5309370 Wed, 12 Oct 2011 04:00:00 +0100 5309370 http://www.medworm.com/index.php?rid=5309369&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02609.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5309369 Wed, 12 Oct 2011 04:00:00 +0100 5309369 http://www.medworm.com/index.php?rid=5309368&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02610.x AbstractChronic intra‐renal hypoxia has been regarded as a pathogenic factor of progressive renal damage. However, the lack of available human data has impeded the progress in this field. In this work, blood oxygenation level‐dependent (BOLD) MRI was used to determine intra‐renal oxygen status pre‐ and post‐angiotensin receptor blockade (ARB), (olmesartan) treatment in normal subjects, diabetes chronic kidney disease (CKD) patients, and non‐diabetes CKD patients. The mean R2*, which represents intra‐renal oxygenation, was significantly lower in the control group than in the CKD group (12.42 ± 0.53 s‐1 vs. 18.89 ± 3.15 s‐1, p < 0.01), indicating the presence of intra‐renal hypoxia in the CKD patients. The olmesartan treatment induced a 16.2 ± 7.7 % decrement of the... Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5309368 Wed, 12 Oct 2011 04:00:00 +0100 5309368 http://www.medworm.com/index.php?rid=5309367&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02611.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5309367 Wed, 12 Oct 2011 04:00:00 +0100 5309367 http://www.medworm.com/index.php?rid=5309366&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02612.x Conclusion:  Development of sarcoidosis‐like granulomatosis in patients treated with TNF‐α antagonists is a phenomenon previously under‐recognised. All 3 anti‐TNF agents have been observed to cause this phenomenon, suggesting of a ‘class effect’ rather than being drug specific. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5309366 Wed, 12 Oct 2011 04:00:00 +0100 5309366 http://www.medworm.com/index.php?rid=5309365&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02613.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5309365 Wed, 12 Oct 2011 04:00:00 +0100 5309365 http://www.medworm.com/index.php?rid=5300874&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02596.x Conclusions:  This prospective observational study found almost a quarter of haematology patients experience a CVC‐related complication. An association was found with number of attempts at insertion and immediate complications; other risk factors included anatomical location, underlying disease and duration of catheterisation. The relatively high complication rate, compared to reports of non‐haematology patients, highlights the need to improve CVC management, a vital part of care for this population. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5300874 Fri, 07 Oct 2011 04:00:00 +0100 5300874 http://www.medworm.com/index.php?rid=5300873&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02597.x Conclusions:  With the exception of body image difficulties, there is little association between BMI and self‐reported sexual difficulties. Furthermore, extreme sexual and emotional satisfaction appeared to be associated with the presence or absence of sexual difficulties and not overly influenced by BMI. Overall, clinicians and patients should be aware that being overweight is not necessarily detrimental to sexual functioning. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5300873 Fri, 07 Oct 2011 04:00:00 +0100 5300873 http://www.medworm.com/index.php?rid=5300872&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02598.x Conclusions  While some information is known about Indigenous Australian healing beliefs and practices associated with cancer treatment, few studies have addressed ways in which Indigenous and biomedical approaches to cancer treatment might be integrated. Some recent work has examined the role of belief in cancer treatment, specifically bush medicine, but more research is required. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5300872 Fri, 07 Oct 2011 04:00:00 +0100 5300872 http://www.medworm.com/index.php?rid=5300871&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02599.x Thirty‐one umbilical cord blood transplants performed in Western Australia were retrospectively examined in order to document local experience and relevant prognostic factors. Three cord units were from HLA matched siblings and the remainder were unrelated single (n=22) or double (n=6) cord blood transplants. Twenty patients were transplanted for malignant conditions and eleven for non‐malignant conditions. Cord units contained a median of 5.6 x 107 total nucleated cells / kg and 1.4x105 CD34+ cells/kg. Cumulative incidence of neutrophil engraftment was 76% at day 60. Of those who did not engraft, two patients remain alive following subsequent allogeneic bone marrow transplant. There were no deaths due to graft‐versus‐host‐disease. Overall survival (OS) at median follow up of 28 ... Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5300871 Fri, 07 Oct 2011 04:00:00 +0100 5300871 http://www.medworm.com/index.php?rid=5300870&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02600.x Conclusions  Spontaneous conversion occurred in 54%, increasing to 77% when AF had persisted less than 48 hours. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5300870 Fri, 07 Oct 2011 04:00:00 +0100 5300870 http://www.medworm.com/index.php?rid=5300869&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02601.x Conclusion:  In the absence of a reliable in vitro test, structured drug challenges allow identification of selective and cross‐reactive NSAID hypersensitivity syndromes. NSAID‐induced anaphylaxis is often associated with selective hypersensitivity and patients may not need to avoid other NSAIDs. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5300869 Fri, 07 Oct 2011 04:00:00 +0100 5300869 http://www.medworm.com/index.php?rid=5300868&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02602.x Conclusions  Influenza‐associated community onset‐MRSA pneumonia was infrequently identified in the 2009 H1N1 season in Queensland, despite community‐onset MRSA skin and soft tissue infections being very common. Although post‐influenza MRSA pneumonia is of great concern, its influence on empiric prescribing guidelines should take into account its incidence relative to other secondary bacterial pathogens. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5300868 Fri, 07 Oct 2011 04:00:00 +0100 5300868 http://www.medworm.com/index.php?rid=5300867&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02603.x Conclusion:  Telestroke has the potential to bridge the gap of rural‐metropolitan inequality in acute stroke care. Our Telestroke system successfully introduced safe thrombolysis and early specialist review of acute stroke patients in rural Victoria. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5300867 Fri, 07 Oct 2011 04:00:00 +0100 5300867 http://www.medworm.com/index.php?rid=5371874&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02630.x AbstractAbnormal immunophenotypes of hematopoietic cells in MDS have been identified by flow cytometry (FCM) as typical characteristic of myeloid dysplasia. Considering that most of MDS patients show varying degrees of erythroid dysplasia, we describe the immunophenotypic feature of erythroblasts. Under‐expression of CD71 and over‐expression of CD105 were detected in erythroblasts of MDS patients compared with non‐clonal cytopenias. Based on these, we developed a convenient and economical tool for differential diagnosis of MDS. The development index (DI) acquired by log transformation of the CD71/CD105 expression ratio was used to denote the erythroid maturation and distinguish the cases of non‐clonal cytopenias diseases from low risk MDS. The diagnostic quality of DI in distinguis... Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5371874 Sat, 01 Oct 2011 04:00:00 +0100 5371874 http://www.medworm.com/index.php?rid=5320011&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02606.x ABSTRACTCardiac magnetic resonance imaging (CMR) has matured into a robust, accurate and highly reproducible imaging modality for the assessment of cardiac function and ischemic heart disease (IHD). The unique physical properties of CMR permit depiction of pathology‐specific tissue contrast based on differences in tissue composition such as myocardial oedema, necrosis and fibrosis. This can be imaged at high spatial resolution allowing characterization of the acuity of an ischemic event, the presence and extent of myocardial ischemia, necrosis and viability. Prognostically important information obtained from CMR evaluation of IHD such as left ventricular ejection fraction, infarct size and transmurality, infarct location and the presence of intraventricular mechanical dyssynchrony may be... Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5320011 Sat, 01 Oct 2011 04:00:00 +0100 5320011 http://www.medworm.com/index.php?rid=5309364&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02614.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5309364 Sat, 01 Oct 2011 04:00:00 +0100 5309364 http://www.medworm.com/index.php?rid=5300866&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02604.x Conclusion:  The introduction of mandatory cardiac testing for early‐stage disease spilled over to the metastatic setting. While deviation from guidelines may be warranted in some cases, this study suggests under‐utilisation of cardiac testing among patients treated with trastuzumab in the metastatic setting. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5300866 Sat, 01 Oct 2011 04:00:00 +0100 5300866 http://www.medworm.com/index.php?rid=5279889&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02574.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5279889 Sat, 01 Oct 2011 04:00:00 +0100 5279889 http://www.medworm.com/index.php?rid=5279888&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02575.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5279888 Sat, 01 Oct 2011 04:00:00 +0100 5279888 http://www.medworm.com/index.php?rid=5279887&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02577.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5279887 Sat, 01 Oct 2011 04:00:00 +0100 5279887 http://www.medworm.com/index.php?rid=5279886&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02573.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5279886 Sat, 01 Oct 2011 04:00:00 +0100 5279886 http://www.medworm.com/index.php?rid=5279885&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02579.x This study was aimed to identify safety duration and complications of anticoagulation withholding in patients with prosthetic heart valves and intracranial haemorrhage. This was a retrospective descriptive study in 26 prosthetic heart valve patients hospitalised in Srinagarind Hospital, Khon Kaen University because of intracranial haemorrhage from 2003 to 2008. Range of anticoagulation withholding was 1 to 26 days with mean 8.5 ± 7.7 days. Most patients (84.6%) were withheld anticoagulation for less than 14 days. There were five in‐hospital deaths mostly within 3 days of admission from severe intracranial haemorrhage. No data of reintroduction of anticoagulation was found in three patients because they were lost to follow up. One patient had right basal ganglia infarction after ... Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5279885 Sat, 01 Oct 2011 04:00:00 +0100 5279885 http://www.medworm.com/index.php?rid=5279884&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2010.02330.x Conclusions:  In this pre‐intervention cohort of selected acute stroke inpatients, stroke severity was mild to moderate and subsequent clinical outcomes were favourable in the majority. The findings from this study provide a comprehensive description of 90‐day health outcomes of patients who have experienced a mild–moderate stroke managed in stroke care units across metropolitan NSW and provide valuable data to inform the subsequent cluster trial. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5279884 Sat, 01 Oct 2011 04:00:00 +0100 5279884 http://www.medworm.com/index.php?rid=5279883&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02534.x Conclusion:  This study found less intensive management of cardiovascular risk factors in CHD patients, particularly among women, despite equivalent cardiovascular risk. This study has shown that these patients have multiple risk factors where gender also plays a role. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5279883 Sat, 01 Oct 2011 04:00:00 +0100 5279883 http://www.medworm.com/index.php?rid=5279882&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02508.x We describe Legionella pneumophila pneumonia and abscess formation in an immunosuppressed patient receiving corticosteroid therapy for metastatic breast carcinoma. The predisposing role of corticosteroids is discussed and the management of this complication is reviewed. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5279882 Sat, 01 Oct 2011 04:00:00 +0100 5279882 http://www.medworm.com/index.php?rid=5279881&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02581.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5279881 Sat, 01 Oct 2011 04:00:00 +0100 5279881 http://www.medworm.com/index.php?rid=5202055&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02547.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5202055 Thu, 01 Sep 2011 04:00:00 +0100 5202055 http://www.medworm.com/index.php?rid=5202054&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02558.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5202054 Thu, 01 Sep 2011 04:00:00 +0100 5202054 http://www.medworm.com/index.php?rid=5202053&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02553.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5202053 Thu, 01 Sep 2011 04:00:00 +0100 5202053 http://www.medworm.com/index.php?rid=5202052&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02550.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5202052 Thu, 01 Sep 2011 04:00:00 +0100 5202052 http://www.medworm.com/index.php?rid=5202051&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02561.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5202051 Thu, 01 Sep 2011 04:00:00 +0100 5202051 http://www.medworm.com/index.php?rid=5202050&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02555.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5202050 Thu, 01 Sep 2011 04:00:00 +0100 5202050 http://www.medworm.com/index.php?rid=5202049&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02552.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5202049 Thu, 01 Sep 2011 04:00:00 +0100 5202049 http://www.medworm.com/index.php?rid=5202048&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02551.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5202048 Thu, 01 Sep 2011 04:00:00 +0100 5202048 http://www.medworm.com/index.php?rid=5202047&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02546.x We report the case of a 56‐year‐old man with the rare autoimmune pathologies of alternating hypothyroidism and hyperthyroidism due to thyroid‐stimulating hormone receptor antibodies, and rheumatoid arthritis as manifestations of a human immunodeficiency virus‐related immune reconstitution inflammatory syndrome. The patient also developed overt progression of a pre‐existing skin malignancy that may also be related. This case highlights immune reconstitution syndrome as an important differential diagnosis following antiretroviral therapy commencement, and that a high index of suspicion should be maintained for this rare but important cluster of conditions. Furthermore, the patient's genetic predisposition to autoimmunity provides helpful insights into the pathogenesis of these diso... Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5202047 Thu, 01 Sep 2011 04:00:00 +0100 5202047 http://www.medworm.com/index.php?rid=5202046&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02545.x We report a case where the diagnosis was not considered from the outset and review the current clinical and histopathological markers available to assist in the diagnosis of parathyroid carcinoma. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5202046 Thu, 01 Sep 2011 04:00:00 +0100 5202046 http://www.medworm.com/index.php?rid=5202045&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2009.02162.x Conclusions: In patients with acute ischaemic stroke, platelet count and history of hypertension are the only determinants of MPV. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5202045 Thu, 01 Sep 2011 04:00:00 +0100 5202045 http://www.medworm.com/index.php?rid=5202044&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2010.02205.x Conclusion: In PE patients with right ventricular dysfunction and unstable haemodynamics, combined catheter thrombus fragmentation and thrombolysis appears to be a useful therapeutic strategy. In PE patients with right ventricular dysfunction and stable haemodynamics, randomized trials are still required to show that combination of catheter‐directed thrombus fragmentation and thrombolysis is superior to standard anticoagulation. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5202044 Thu, 01 Sep 2011 04:00:00 +0100 5202044 http://www.medworm.com/index.php?rid=5202043&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02501.x Conclusions:  The encouraged 6MWT identifies reduced exercise capacity and provides a valid estimate of aerobic capacity in EIPAH. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5202043 Thu, 01 Sep 2011 04:00:00 +0100 5202043 http://www.medworm.com/index.php?rid=5202042&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2009.02136.x Conclusion: OPAT for osteoarticular infections is both feasible and effective in a tropical environment, including for indigenous patients. Extension of treatment to remote‐dwelling patients is facilitated by the innovative use of self‐care units and administration of treatment at remote clinics. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5202042 Thu, 01 Sep 2011 04:00:00 +0100 5202042 http://www.medworm.com/index.php?rid=5202041&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2009.02105.x Conclusions:  With 25% of patients having a claim for a GP service within 4 days of discharge, discharge summaries need to reach community‐based health professionals within this time. Most patients visited their community pharmacy within 2 weeks of hospital discharge and before they saw their GP. Pharmacists are not routinely advised of hospitalization or provided with discharge summaries. More active engagement of this professional group in the continuum of care might improve care after hospital discharge. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5202041 Thu, 01 Sep 2011 04:00:00 +0100 5202041 http://www.medworm.com/index.php?rid=5202040&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02560.x AbstractThe vulnerability of older people to serious underlying medical illness and adverse effects of psychotropics means that the safe and effective treatment of severe agitation can be lifesaving, the primary management goals being to create a safe environment for the patient and others, and to facilitate assessment and treatment. We review the literature on acute sedation and provide practical guidelines for the management of this problem addressing a range of issues, including aetiology, assessment, pharmacological and non‐pharmacological strategies, restraint and consent. The assessment of the agitated older patient must include concurrent assessment of the likely aetiology of, the risks posed by, and the risks/benefits of management options for, the agitation. A range of environme... Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5202040 Thu, 01 Sep 2011 04:00:00 +0100 5202040 http://www.medworm.com/index.php?rid=5202039&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02554.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5202039 Thu, 01 Sep 2011 04:00:00 +0100 5202039 http://www.medworm.com/index.php?rid=5189611&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02582.x Conclusions:  There is wide variability in the investigation and management of peri‐operative glucocorticoid requirements for patients undergoing pituitary surgery in Australasia. This may reflect limited evidence to define optimal management and that further well‐designed studies are needed. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5189611 Wed, 31 Aug 2011 23:00:00 +0100 5189611 http://www.medworm.com/index.php?rid=5189610&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02583.x Conclusion:  Infection, inflammatory conditions, moderate‐heavy exercise, and potentially fast food consumption, appear to precipitate high‐risk ACS. Increased inflammation as measured by CRP was not consistently detected despite the identification of an ACS precipitant. Strategies that target improved overall health may also lead to fewer ACS events through a reduction in triggers. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5189610 Wed, 31 Aug 2011 23:00:00 +0100 5189610 http://www.medworm.com/index.php?rid=5189609&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02584.x Conclusions:  In the whole Chinese population, the D allele was significantly linked with EH susceptibility. However, the relation between the I/D polymorphism and EH is still inconclusive in some national minorities and must await larger scale studies. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5189609 Wed, 31 Aug 2011 23:00:00 +0100 5189609 http://www.medworm.com/index.php?rid=5189608&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02585.x Conclusions  This preliminary CEA based largely on contemporary real world data suggests population‐based FOBT screening for CRC is attractive. Planned ongoing data collection will enable repeated analyses over time, using the same methodology in the same patient populations, permitting an accurate analysis of the impact of new therapies and changing practice. Similar CEA using real world data related to other disease types and interventions appears desirable. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5189608 Wed, 31 Aug 2011 23:00:00 +0100 5189608 http://www.medworm.com/index.php?rid=5189607&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02586.x Conclusion:  Individual GPs care for few IBD patients and have variable attitudes in their practice. Whether improvement can realistically be achieved given individual GP's paucity of patients, is questionable. These data support the provision of better support and specific action plans for IBD patients. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5189607 Wed, 31 Aug 2011 23:00:00 +0100 5189607 http://www.medworm.com/index.php?rid=5189606&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02587.x Conclusions  Polymorphic analysis may be a predictive tool to identify those at high‐risk of LON. Prospective studies are required to definitively establish if LON or FCGR3A‐158V/V genotype influences outcome. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5189606 Sun, 31 Jul 2011 23:00:00 +0100 5189606 http://www.medworm.com/index.php?rid=5115468&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02507.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5115468 Sun, 31 Jul 2011 23:00:00 +0100 5115468 http://www.medworm.com/index.php?rid=5115467&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02518.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5115467 Sun, 31 Jul 2011 23:00:00 +0100 5115467 http://www.medworm.com/index.php?rid=5115466&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02549.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5115466 Sun, 31 Jul 2011 23:00:00 +0100 5115466 http://www.medworm.com/index.php?rid=5115465&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02543.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5115465 Sun, 31 Jul 2011 23:00:00 +0100 5115465 http://www.medworm.com/index.php?rid=5115464&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02542.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5115464 Sun, 31 Jul 2011 23:00:00 +0100 5115464 http://www.medworm.com/index.php?rid=5115463&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2010.02366.x We report a case of TRALI in a patient with neutropenia and discuss the possible factors contributing to the respiratory symptoms in this patient. We also emphasise the importance of recognising mild cases of TRALI in order to investigate the implicated donor/s appropriately, and to minimise the risk for more severe episodes in other patients. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5115463 Sun, 31 Jul 2011 23:00:00 +0100 5115463 http://www.medworm.com/index.php?rid=5115462&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02515.x This article aims to increase the reader's awareness of Guidelines developed by the National Health and Medical Research Council which are intended to assist health practitioners in making decisions about the use or disclosure of genetic information in certain circumstances.Discussion:  The Guidelines establish when, by whom and in what manner, use or disclosure of genetic information may take place. The Guidelines outline the factors that health practitioners should consider when determining whether use or disclosure is necessary to lessen or prevent a serious threat to an individual's life, health or safety. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5115462 Sun, 31 Jul 2011 23:00:00 +0100 5115462 http://www.medworm.com/index.php?rid=5115461&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2009.02104.x Conclusion:  Among Asian patients who have undergone drug‐eluting stent implantation, 12.8% discontinued dual antiplatelet therapy within 12 months. Living alone is associated with a fivefold increase in risk of premature drug discontinuation. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5115461 Sun, 31 Jul 2011 23:00:00 +0100 5115461 http://www.medworm.com/index.php?rid=5115460&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2010.02165.x Conclusion: Acute gout episodes in hospital are variably investigated and treated with frequent suboptimal management. We recommend establishment of a hospital‐wide protocol to support decision‐making regarding investigations, treatment and follow up. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5115460 Sun, 31 Jul 2011 23:00:00 +0100 5115460 http://www.medworm.com/index.php?rid=5115459&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02544.x AbstractMobilization and collection of haemopoietic stem and progenitor cells (HSPC) is the cornerstone of autologous and allogeneic stem cell transplantation for a wide variety of haematological and some non‐haematological malignancies. Centres providing this service face the challenge of optimizing the likelihood of successful collection of transplantable doses of cells, while maximizing the efficiency of the apheresis unit and minimizing the risk of toxicity as well as mobilization failure. Recent developments in the understanding of the molecular mechanisms of mobilization have led to the emergence of novel strategies for HSPC mobilization, which may assist in meeting these imperatives. The task for clinicians is how to incorporate the use of these strategies into practice, in the li... Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5115459 Sun, 31 Jul 2011 23:00:00 +0100 5115459 http://www.medworm.com/index.php?rid=5115458&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02548.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5115458 Sun, 31 Jul 2011 23:00:00 +0100 5115458 http://www.medworm.com/index.php?rid=5060818&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02562.x Conclusion:  Medical patients admitted from the ED of a referral center have a 30‐day re‐admission rate of 16.7%. Post‐discharge care should focus on patients with higher Charlson score, longer hospitalization, anemia, and underlying active malignancy, which are independent predictive factors for 30‐day readmission. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5060818 Sun, 24 Jul 2011 23:00:00 +0100 5060818 http://www.medworm.com/index.php?rid=5060817&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02563.x Conclusions:  Long term beta‐blocker treatment did not adversely affect lung function, respiratory symptom scores or survival, but was associated with increased risk of respiratory exacerbations. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5060817 Sun, 24 Jul 2011 23:00:00 +0100 5060817 http://www.medworm.com/index.php?rid=5060816&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02564.x Conclusions:  Early stroke risk was low after an Emergency diagnosis of TIA and significantly lower in admitted patients. Moderate‐high ABCD2 scores did not predict early stroke risk. We suggest local validation of ABCD2 before its clinical use and a review of its place in national guidelines. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5060816 Sun, 24 Jul 2011 23:00:00 +0100 5060816 http://www.medworm.com/index.php?rid=5060815&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02565.x Conclusion  This study demonstrates that the serum eosinophil count and FEV1 combined with aspects of a clinical history may provide a simple and practical alternative to assessment of airway (sputum) eosinophilia in the clinical setting. A full blood count can be performed at a substantially lesser cost and with greater accessibility than induced sputum. We feel the time has come for the clinical utility of the serum eosinophil count to be revisited. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5060815 Sun, 24 Jul 2011 23:00:00 +0100 5060815 http://www.medworm.com/index.php?rid=5060814&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02566.x Conclusions  Anaemia is highly prevalent amongst medical inpatients with variation due to gender, age, race, and reason for admission. Anaemia independently predicts for prolonged hospital stay, increased mortality, and shorter time to readmission but is usually not documented or investigated in this setting. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5060814 Sun, 24 Jul 2011 23:00:00 +0100 5060814 http://www.medworm.com/index.php?rid=5060813&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02567.x Conclusions:  Cases of AH manifesting as SJS/TENS in Australians are more likely to be in those of Asian heritage. The place of routine testing for HLA‐B*5801 prior to commencing allopurinol therapy requires further investigation. However, Han Chinese origin patients commencing allopurinol might be informed of the test and may elect to have it performed as there are alternative hypouricaemic medicines such as probenecid thereby reducing the risk of a catastrophic reaction to allopurinol. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5060813 Sun, 24 Jul 2011 23:00:00 +0100 5060813 http://www.medworm.com/index.php?rid=5060812&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02568.x AbstractEstimates of the prevalence of paraproteinaemia vary, from 1% in persons aged over 25 years to 10% in those aged over 80 years, although there are limited data from well‐defined populations. We performed a population‐based, cross‐sectional study to determine the prevalence of paraproteinaemia in Australians aged 50 years and over, using data and serum collected in the Blue Mountains Eye Study. Serum samples from 2933 patients were analysed by capillary zone electropheresis and where indicated, immunosubtraction, which allowed for both quantitation and isotyping. A paraprotein was detected in 134 of the 2933 samples, giving an overall prevalence of 4.6% (95% confidence interval, 3.8‐5.3%). Presence of a paraprotein was strongly age‐related (ptrend= 0.001), with a prevalenc... Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5060812 Sun, 24 Jul 2011 23:00:00 +0100 5060812 http://www.medworm.com/index.php?rid=5060811&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02569.x Conclusions:  HBV reactivation may result in serious consequences, including death. Tuberculosis screening prior to bDMARD treatment is already standard practice, as is HBV screening for patients undergoing cancer chemotherapy. Implementing HBV screening for all patients prior to bDMARD treatment can identify patients with chronic HBV who may require anti‐viral therapy. (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5060811 Thu, 30 Jun 2011 23:00:00 +0100 5060811 http://www.medworm.com/index.php?rid=5046446&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02524.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5046446 Thu, 30 Jun 2011 23:00:00 +0100 5046446 http://www.medworm.com/index.php?rid=5046445&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02519.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5046445 Thu, 30 Jun 2011 23:00:00 +0100 5046445 http://www.medworm.com/index.php?rid=5046444&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02520.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5046444 Thu, 30 Jun 2011 23:00:00 +0100 5046444 http://www.medworm.com/index.php?rid=5046443&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02528.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5046443 Thu, 30 Jun 2011 23:00:00 +0100 5046443 http://www.medworm.com/index.php?rid=5046442&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02521.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5046442 Thu, 30 Jun 2011 23:00:00 +0100 5046442 http://www.medworm.com/index.php?rid=5046441&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02526.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5046441 Thu, 30 Jun 2011 23:00:00 +0100 5046441 http://www.medworm.com/index.php?rid=5046440&cid=s_28862_49_f&fid=28862&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1445-5994.2011.02516.x (Source: Internal Medicine Journal) Internal Medicine Journal journals http://www.medworm.com/rss/comments.php?id=5046440 Thu, 30 Jun 2011 23:00:00 +0100 5046440