MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'International Journal of Clinical Practice' source. Thu, 09 Feb 2012 09:15:09 +0100 http://www.medworm.com/index.php?rid=5672332&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02859.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5672332 Wed, 01 Feb 2012 05:00:00 +0100 5672332 http://www.medworm.com/index.php?rid=5672331&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02858.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5672331 Wed, 01 Feb 2012 05:00:00 +0100 5672331 http://www.medworm.com/index.php?rid=5672330&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02857.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5672330 Wed, 01 Feb 2012 05:00:00 +0100 5672330 http://www.medworm.com/index.php?rid=5672329&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02856.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5672329 Wed, 01 Feb 2012 05:00:00 +0100 5672329 http://www.medworm.com/index.php?rid=5672328&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02855.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5672328 Wed, 01 Feb 2012 05:00:00 +0100 5672328 http://www.medworm.com/index.php?rid=5672327&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02854.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5672327 Wed, 01 Feb 2012 05:00:00 +0100 5672327 http://www.medworm.com/index.php?rid=5672326&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02853.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5672326 Wed, 01 Feb 2012 05:00:00 +0100 5672326 http://www.medworm.com/index.php?rid=5672325&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02852.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5672325 Wed, 01 Feb 2012 05:00:00 +0100 5672325 http://www.medworm.com/index.php?rid=5672324&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02851.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5672324 Wed, 01 Feb 2012 05:00:00 +0100 5672324 http://www.medworm.com/index.php?rid=5672323&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02850.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5672323 Wed, 01 Feb 2012 05:00:00 +0100 5672323 http://www.medworm.com/index.php?rid=5672322&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02849.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5672322 Wed, 01 Feb 2012 05:00:00 +0100 5672322 http://www.medworm.com/index.php?rid=5672321&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02848.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5672321 Wed, 01 Feb 2012 05:00:00 +0100 5672321 http://www.medworm.com/index.php?rid=5672320&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02847.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5672320 Wed, 01 Feb 2012 05:00:00 +0100 5672320 http://www.medworm.com/index.php?rid=5672319&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02860.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5672319 Wed, 01 Feb 2012 05:00:00 +0100 5672319 http://www.medworm.com/index.php?rid=5672318&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02806.x SummaryThe aim of this study was to perform a head‐to‐head comparison of efficacy and safety profile between 60 mg denosumab (Den) subcutaneously (SC) per 6 months (Q6M) and 70 mg alendronate (Aln) orally per week (QW) for postmenopausal women with low bone mineral density. We searched electronic databases comparing efficacy and safety of Den SC Q6M and Aln QW in postmenopausal women. The primary outcomes of efficacy evaluation in included trials were incidence of clinical fracture in both groups and bone mineral density (BMD) at different skeletal sites. And adverse events (AEs), including incidence of neoplasms and infections, were considered as secondary outcomes. Following the instructions of ‘Cochrane Handbook for systematic Reviews of Interventions 5.0.2’, we identified... International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5672318 Wed, 01 Feb 2012 05:00:00 +0100 5672318 http://www.medworm.com/index.php?rid=5642314&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02885.x Conclusions:  Vilazodone represents another option for the treatment of MDD. Vilazodone appears to have a favourable weight‐gain profile based on short‐term studies. Sexual side‐effects were not consistently demonstrated when assessed using clinical rating scales but spontaneously reported AEs related to sexual functioning were observed. Additional controlled data regarding long‐term efficacy and effectiveness will help characterise this new agent when used in maintenance treatment. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5642314 Mon, 30 Jan 2012 17:35:53 +0100 5642314 http://www.medworm.com/index.php?rid=5633699&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02886.x Conclusion:  The transplantation of BMCs as well as TRCs proved to be safe and feasible. Improvements of microcirculation and complete wound healing were observed in the transplant groups. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5633699 Fri, 27 Jan 2012 14:21:21 +0100 5633699 http://www.medworm.com/index.php?rid=5615438&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02846.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5615438 Sat, 21 Jan 2012 14:00:01 +0100 5615438 http://www.medworm.com/index.php?rid=5615437&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02834.x Linked Comment: http://www.youtube.com/IJCPeditorial (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5615437 Sat, 21 Jan 2012 14:00:00 +0100 5615437 http://www.medworm.com/index.php?rid=5615436&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02863.x Conclusions:  A decade’s experience of percutaneous lead extraction suggests that a high procedural success rate with a low complication rate is achieved in a high‐volume centre. During this time, an increase in both defibrillator and CS lead explantation and a rising trend in laser assistance with almost 50% of cases needing laser usage were observed. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5615436 Sat, 21 Jan 2012 13:59:58 +0100 5615436 http://www.medworm.com/index.php?rid=5615435&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02839.x SummaryTo evaluate the efficacy and safety of moxifloxacin monotherapy for treatment of complicated intra‐abdominal infections. PubMed, EMBASE, Science Direct, ClinicalTrials.gov and Cochrane Central Register of Controlled Trials were searched to retrieve randomised controlled trials (RCTs) compared moxifloxacin monotherapy with other antibiotics in the treatment of complicated intra‐abdominal infections from January 1999 to July 2011. A meta‐analysis of all included randomised controlled trials was performed. Four randomised controlled trials including a total of 2444 patients with complicated intra‐abdominal infections were included for meta‐analysis. The results of the meta‐analysis indicated that the moxifloxacin was associated with similar clinical cure rate (four RCTs, 19... International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5615435 Sat, 21 Jan 2012 13:59:56 +0100 5615435 http://www.medworm.com/index.php?rid=5615434&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02837.x SummaryTo determine the efficacy of teriparatide supplementation for improving bone mineral density (BMD) and fracture risk in postmenopausal osteoporosis and if effects vary with factors. We identified eight randomised controlled trials (n = 2388) using electronic databases, supplemented by a hand‐search of the reference lists. All trials aimed to evaluate the efficacy of daily subcutaneous teriparatide injection in postmenopausal osteoporosis. The main outcomes were fracture risk and percentage change of BMD from baseline. Data were pooled by employing a random‐effect model. In trials that reported BMD as an outcome, treatment was associated with an increase of bone mass of 8.14% [95% confidence interval (CI): 6.72–9.55%; eight trials, n = 2206] in spine and 2.48% (95% CI: ... International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5615434 Sat, 21 Jan 2012 13:59:55 +0100 5615434 http://www.medworm.com/index.php?rid=5615433&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02845.x SummaryIn recent years, the role of PET imaging in the prediction of mild cognitive impairment (MCI) to Alzheimer’s disease (AD) conversion has been the subject of many longitudinal studies. The purpose of this study was to perform a meta‐analysis to estimate the diagnostic accuracy of 18F‐fluoro‐2‐deoxyglucose‐positron emission tomography (FDG‐PET) and 11C‐Pittsburgh Compound B‐positron emission tomography (PIB‐PET) for prediction of short‐term conversion to AD in patients with MCI. The MEDLINE and EMBASE databases were systematically searched for relevant studies. Methodological quality of the included studies was assessed. Sensitivities and specificities of PET in individual studies were calculated and meta‐analysis was undertaken with a random‐effects model. A... International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5615433 Sat, 21 Jan 2012 13:59:53 +0100 5615433 http://www.medworm.com/index.php?rid=5615432&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02861.x Conclusion:  The take home message for clinicians is hoarse voice associated with shortness of breath needs specialist referral. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5615432 Sat, 21 Jan 2012 13:59:51 +0100 5615432 http://www.medworm.com/index.php?rid=5615431&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02877.x Conclusions regarding the cost‐effectives were changed upon sensitivity analysis with the following variables: time horizon, cost of bupropion, efficacy of either drug, age and the incidence of smoking related disease. Varenicline dominated bupropion in most cost‐effectiveness models. However, applicability of models to clinical practice and variables which changed conclusion of cost‐effectiveness should be considered in the interpretation of results. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5615431 Sat, 21 Jan 2012 13:59:50 +0100 5615431 http://www.medworm.com/index.php?rid=5615430&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02842.x SummaryMenière’s disease (MD) is frequently over‐diagnosed in both primary and secondary care. This is unfortunate given the significant medical and social implications of such a diagnosis. Difficulties may arise in differentiating the patient with true MD from those individuals with less clearly defined disorders of cochleo‐vestibular function. In this review, we suggest a practical evidence based approach to assessment and management of the patient with MD. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5615430 Sat, 21 Jan 2012 13:59:48 +0100 5615430 http://www.medworm.com/index.php?rid=5615429&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02840.x Conclusion:  The value of FENO50 > 34 ppb has high predictive value of PC20M < 16 in patients with suspected asthma in whom bronchodilating test failed to demonstrate reversibility or was not indicated. However, FENO50 ≤ 34 ppb does not rule out BHR and should prompt the clinician to ask for a methacholine challenge. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5615429 Sat, 21 Jan 2012 13:59:47 +0100 5615429 http://www.medworm.com/index.php?rid=5615428&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02864.x Conclusion:  Initial treatment with doxazosin for patients with IPSS‐V/S > 1 and tolterodine for patients with IPSS‐V/S ≤ 1 is safe and feasible. Elderly people (≥ 70 years) and patients with Qmax < 10 ml/s are more likely to have increased PVR (≥ 50 ml). (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5615428 Sat, 21 Jan 2012 13:59:42 +0100 5615428 http://www.medworm.com/index.php?rid=5615427&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02836.x Conclusion:  Residual joint swelling was found more commonly in RA patients than in PsA patients following TNFi therapy, whereas residual tender joints occurred more frequently in PsA; this may reflect enthesiopathy or periostitis. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5615427 Sat, 21 Jan 2012 13:59:39 +0100 5615427 http://www.medworm.com/index.php?rid=5615426&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02841.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5615426 Sat, 21 Jan 2012 13:59:37 +0100 5615426 http://www.medworm.com/index.php?rid=5615425&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02844.x Linked Comment: http://www.youtube.com/IJCPeditorial (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5615425 Sat, 21 Jan 2012 13:59:35 +0100 5615425 http://www.medworm.com/index.php?rid=5615424&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02884.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5615424 Sat, 21 Jan 2012 13:59:32 +0100 5615424 http://www.medworm.com/index.php?rid=5615423&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02865.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5615423 Sat, 21 Jan 2012 13:59:30 +0100 5615423 http://www.medworm.com/index.php?rid=5602524&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02702.x Conclusion:  In children with long‐term diabetes, although relatively metabolic compensation, the cheiroarthropathy has been occurred accompanying by elevated concentrations of metalloproteinase's and their tissue inhibitors. The presence of cheiroarthropathy could be treated as a simple test to identification the patients endangered to develop chronic vascular complication. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5602524 Sun, 01 Jan 2012 05:00:00 +0100 5602524 http://www.medworm.com/index.php?rid=5575347&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02890.x Conclusions:  Inhaled loxapine is a non‐invasive treatment option for the management of agitation associated with schizophrenia or bipolar disorder. Effect sizes for inhaled loxapine vs. placebo are robust and on par with those observed with intramuscular antipsychotics and benzodiazepines. Onset of action is rapid. The magnitudes of the effect sizes were generally larger for the 10 mg dose vs. the 5 mg dose, and the overall data supports the 10 mg dose as the dominant choice. The efficacy profile of inhaled loxapine will need to be viewed within the context of its pulmonary safety profile. The advisers to the Food and Drug Administration recommended that inhaled loxapine be restricted to a single dose in 24 h and be subject to a Risk Evaluation and Mitigation Strategy programm... International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5575347 Sun, 01 Jan 2012 05:00:00 +0100 5575347 http://www.medworm.com/index.php?rid=5531195&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02838.x Conclusions:  Most patients were prescribed 5–10 mg/day oxybutynin ER as both starting and maintenance doses, with a dose escalation rate of only 14.9%. Prescription of > 10 mg/day oxybutynin ER was not frequent in real life practice. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5531195 Fri, 23 Dec 2011 03:05:38 +0100 5531195 http://www.medworm.com/index.php?rid=5531196&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02833.x This study was designed to determine whether LTOT improves survival or not in severely hypoxaemic COPD patients.Materials:  COPD patients prescribed oxygen concentrator were consecutively included. Patients’ baseline characteristics were noted. During follow‐up, patients were divided into three groups according to LTOT utilisation: (i) non‐utilisers, (ii) intermittent utilisers (< 15 h/day) and (iii) true utilisers (≥ 15 h/day). Patients’ status (live or death) and, if died, the date of death were checked throughout the study. The factors which might influence mortality during 5‐year period were analysed.Results:  Two‐hundred and twenty‐eight patients completed the study. Of these patients, 55 were in Group 1, 112 were in Group 2 and 61 were in Group 3. Regar... International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5531196 Tue, 20 Dec 2011 05:00:00 +0100 5531196 http://www.medworm.com/index.php?rid=5510553&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02813.x Linked Comment: Hackett. Int J Clin Pract 2012; 66: 113. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5510553 Sat, 17 Dec 2011 02:27:32 +0100 5510553 http://www.medworm.com/index.php?rid=5510552&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02801.x Linked Comment: Kirby et al. Int J Clin Pract 2012; 66: 113‐4. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5510552 Sat, 17 Dec 2011 02:27:30 +0100 5510552 http://www.medworm.com/index.php?rid=5510551&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02817.x Conclusions:  Strong evidence exists for the effectiveness of Alexander Technique lessons for chronic back pain and moderate evidence in Parkinson’s‐associated disability. Preliminary evidence suggests that Alexander Technique lessons may lead to improvements in balance skills in the elderly, in general chronic pain, posture, respiratory function and stuttering, but there is insufficient evidence to support recommendations in these areas. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5510551 Sat, 17 Dec 2011 02:27:28 +0100 5510551 http://www.medworm.com/index.php?rid=5510550&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02795.x Conclusion:  Obstructive sleep apnoea syndrome is associated with high frequency of DGM. In addition, the progression of disease from simple snoring and mild OSAS to severe OSAS increases the rate of DGM. Thus, DGM especially in patients with severe OSAS should be examined in regular periods. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5510550 Sat, 17 Dec 2011 02:27:26 +0100 5510550 http://www.medworm.com/index.php?rid=5510549&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02811.x Conclusion:  Morbidity and mortality of elderly patients was significantly higher in August compared with November, substantiating the informal term ‘Augustitis’ for the Greek elderly. Large, prospective population‐based studies are warranted to further enlighten this field. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5510549 Sat, 17 Dec 2011 02:27:25 +0100 5510549 http://www.medworm.com/index.php?rid=5510548&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02791.x Conclusions:  A potential predictor of treatment benefit was found for caregivers of PD patients with better cognitive functioning. This study did not find treatment effect modifiers for PD patients: demographics, disease stage and time of diagnosis, cognitive functioning, level of baseline psychosocial burden, participating with or without a caregiver, and caregiver changes did not influence treatment outcome. The PEPP seems suitable for the majority of patients. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5510548 Sat, 17 Dec 2011 02:27:23 +0100 5510548 http://www.medworm.com/index.php?rid=5510547&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02775.x Conclusions:  Institution of an on‐site cardiology team‐based approach in the ED significantly reduces D2B time in STEMI patients eligible for primary PCI. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5510547 Sat, 17 Dec 2011 02:27:21 +0100 5510547 http://www.medworm.com/index.php?rid=5510546&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02827.x Conclusions:  Anticoagulation is recommended to be resumed before the 20th day from the cessation to prevent thromboembolic events. A routine SEE before resuming anticoagulation might be helpful to detect asymptomatic recurrent bleeding. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5510546 Sat, 17 Dec 2011 02:27:19 +0100 5510546 http://www.medworm.com/index.php?rid=5510545&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02818.x Conclusions:  Although there is more evidence of treatment maintenance than treatment change, especially in the first year after diagnosis, the amount of therapeutic change remains noteworthy and appears higher than in some previous studies. Prescription patterns for AF therapy suggest that too few high‐risk patients are receiving best practice treatment, and particularly of concern is that some of these patients are being transferred away from best practice treatment over time. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5510545 Sat, 17 Dec 2011 02:27:16 +0100 5510545 http://www.medworm.com/index.php?rid=5510544&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02781.x Conclusions:  The decline in EDP is levelling off and P4P targets are associated with sub‐target‐EDP. Primary care should automate BP measurement and recording. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5510544 Sat, 17 Dec 2011 02:27:14 +0100 5510544 http://www.medworm.com/index.php?rid=5510543&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02814.x This study adds to the evidence that postoperative HCC patients treated with adjuvant AIT show an improvement in disease‐free survival rate or recurrence rate. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5510543 Sat, 17 Dec 2011 02:27:10 +0100 5510543 http://www.medworm.com/index.php?rid=5510542&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02831.x Conclusion:  These data are the first from the South‐East Asian region to demonstrate differences in physician attitudes between medical specialties. Our findings prompt further investigation and confirmation as to whether physicians with particular attitudinal traits are attracted to any particular specialties of medicine, or if physician attitudes are acquired through professional experience and training. In addition, this study offers better insight into the attitudinal differences of physician between medical specialities. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5510542 Sat, 17 Dec 2011 02:27:09 +0100 5510542 http://www.medworm.com/index.php?rid=5510541&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02825.x Summary‘Clinimetrics’ is the term introduced by Alvan R. Feinstein in the early 1980s to indicate a domain concerned with indexes, rating scales and other expressions that are used to describe or measure symptoms, physical signs and other clinical phenomena. Clinimetrics has a set of rules that govern the structure of indexes, the choice of component variables, the evaluation of consistency, validity and responsiveness. This review illustrates how clinimetrics may help expanding the narrow range of information that is currently used in clinical science. It will focus on characteristics and types of clinimetric indexes and their current use. The clinimetric perspective provides an intellectual home for clinical judgment, whose implementation is likely to improve outcomes both in clinica... International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5510541 Sat, 17 Dec 2011 02:27:07 +0100 5510541 http://www.medworm.com/index.php?rid=5510540&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02808.x Linked Comment: http://www.youtube.com/IJCPeditorial (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5510540 Sat, 17 Dec 2011 02:27:05 +0100 5510540 http://www.medworm.com/index.php?rid=5510539&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02816.x Linked Comment: Hodgkinson et al. Int J Clin Pract 2012; 66: 44‐52. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5510539 Sat, 17 Dec 2011 02:27:03 +0100 5510539 http://www.medworm.com/index.php?rid=5510538&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02828.x Linked Comment: Coleman et al. Int J Clin Pract 2012; 66: 53‐63. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5510538 Sat, 17 Dec 2011 02:27:01 +0100 5510538 http://www.medworm.com/index.php?rid=5510537&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02870.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5510537 Sat, 17 Dec 2011 02:27:00 +0100 5510537 http://www.medworm.com/index.php?rid=5499834&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02738.x Conclusion:  A designated primary care physician is crucial for providing recommended diabetes care services for older patients. Strengthening structural capabilities of primary care practices and implementing patient‐centred primary care initiatives in concert with health system reforms are necessary to deliver the co‐ordinated diabetes care with maximised health outcomes. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5499834 Mon, 12 Dec 2011 05:00:00 +0100 5499834 http://www.medworm.com/index.php?rid=5499833&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02773.x Conclusions: A high prevalence of modifiable risk factors for CVD was detected in the population screened. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5499833 Thu, 01 Dec 2011 05:00:00 +0100 5499833 http://www.medworm.com/index.php?rid=5481620&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02805.x SummaryZearalenone (ZEN) is a non‐steroidal mycoestrogen that widely contaminates agricultural products. ZEN and its derivatives share similar molecular mechanisms and activity with estrogens and interact with ERα and ERβ leading to changes in the reproductive system in both animals and humans. The reduced form of ZEN, α‐ZEA ralenol, has been used as an anabolic agent for animals and also proposed as hormonal replacement therapy in postmenopausal women. Furthermore, both zearelanol ZEN and derivatives have been patented as oral contraceptives. ZEN has been widely used in the United States since 1969 to improve fattening rates in cattle by increasing growth rate and feed conversion efficiency. Evidence of human harm from this practice is provided by observations of central precocious... International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5481620 Thu, 01 Dec 2011 05:00:00 +0100 5481620 http://www.medworm.com/index.php?rid=5415409&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02790.x Linked Comment: Refiker. Int J Clin Pract 2011; 65: 1321. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5415409 Thu, 17 Nov 2011 17:02:34 +0100 5415409 http://www.medworm.com/index.php?rid=5415408&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02768.x Linked Comment: Wong et al. Int J Clin Pract 2011; 65: 1321‐2. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5415408 Thu, 17 Nov 2011 17:02:33 +0100 5415408 http://www.medworm.com/index.php?rid=5415407&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02800.x Conclusions:  Hypermethylated gene panels are not currently accurate enough to be used alone for colorectal neoplasia screening. The discovery and evaluation of additional biomarkers with improved sensitivity and specificity is necessary. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5415407 Thu, 17 Nov 2011 17:02:32 +0100 5415407 http://www.medworm.com/index.php?rid=5415406&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02792.x Conclusions:  Although a causal association could not be established, this study has unravelled a wide spectrum of unrecognised post‐CHIKV chronic RMSK disorders. Aetiopathogenesis and risk factors of chronicity need to be studied further. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5415406 Thu, 17 Nov 2011 17:02:30 +0100 5415406 http://www.medworm.com/index.php?rid=5415405&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02810.x This study examined the association of antihypertensive medication use with cognitive decline or dementia using a quantitative meta‐analysis of longitudinal studies. EMBASE and MEDLINE were searched for articles published up to Feb 2011. All studies that examined the relationship between antihypertensive medication use and the incidence of dementia or cognitive decline were included. Pooled relative risk (RR) was calculated using fixed and random‐effects models. Fourteen studies met our inclusion criteria for this meta‐analysis. All subjects were without dementia or cognitive impairment at baseline. There were subjects with (32,658) and without (36,905) antihypertensive medication use. The quantitative meta‐analysis showed that there was no significant difference in incidence of AD... International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5415405 Thu, 17 Nov 2011 17:02:29 +0100 5415405 http://www.medworm.com/index.php?rid=5415404&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02793.x This article is a review of the present pharmacological treatment of PD and current pharmacogenetic data for PD. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5415404 Thu, 17 Nov 2011 17:02:27 +0100 5415404 http://www.medworm.com/index.php?rid=5415403&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02794.x Conclusions:  Temperature Holter monitoring reveals fever peaks that pass otherwise unobserved. Furthermore, chronobiological and complexity analysis of the temperature profile may provide quick and easy ‘hidden information’, not available to conventional care. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5415403 Thu, 17 Nov 2011 17:02:26 +0100 5415403 http://www.medworm.com/index.php?rid=5415402&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02796.x SummaryHeart failure (HF) is a common condition leading to an unfavourable prognosis and impaired quality of life. In this review, we provide an overview of published literature on possible epidemiological and pathophysiological differences between patients with systolic HF of South Asian origin and those from other ethnic groups (mainly White). Systolic HF tends to manifest earlier among South Asians and with frequent hospital admissions. However, survival for such patients appears to be significantly better compared with the White group, which might be associated with different patterns of HF. For example, this could be attributed to a lower prevalence of left ventricular systolic dysfunction in South Asian subjects. Indeed, the high prevalence of hypertension and diabetes among South As... International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5415402 Thu, 17 Nov 2011 17:02:24 +0100 5415402 http://www.medworm.com/index.php?rid=5415401&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02788.x SummaryAcute chest pain is a common presenting complaint of patients attending emergency room departments. Despite this, it can often be challenging to completely exclude a diagnosis of acute coronary syndrome following an initial standard clinical and biochemical evaluation. As a result of this, patients are often admitted to hospital until the treating clinician is satisfied that this diagnosis can be excluded. This process imparts a significant health economic burden by not only increasing hospital bed occupancy rates but also by the unnecessary layering of diagnostic investigations. With the rapid advances in coronary computed tomography angiography (CTA), there has been considerable interest in whether coronary CTA may be a viable alternative to this current standard care. We review t... International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5415401 Thu, 17 Nov 2011 17:02:22 +0100 5415401 http://www.medworm.com/index.php?rid=5415400&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02776.x Conclusions:  South Asian patients were more likely to require re‐admission to treat clinical restenosis of the index lesion. There was no significant long‐term difference in all‐cause mortality between SA and WE patients. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5415400 Thu, 17 Nov 2011 17:02:21 +0100 5415400 http://www.medworm.com/index.php?rid=5415399&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02771.x Conclusion:  The data suggest that therapy with digoxin is associated with an improved mortality and morbidity of HF, including women and patients with non‐systolic HF. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5415399 Thu, 17 Nov 2011 17:02:19 +0100 5415399 http://www.medworm.com/index.php?rid=5415398&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02774.x SummaryAs a result of incessant genetic discoveries and remarkable technological advancements, the availability and the consequent consumer’s request for genetic testing are growing exponentially, leading to the development of a ‘parallel’ market, i.e. the direct‐to‐consumer (DTC) testing, also known as ‘direct access testing’ (DAT). Analogous to the traditional laboratory diagnostics, drawbacks of DTC testing might arise from any step characterising the total testing process, and include poor control of both appropriateness and preanalytical requirements, potential operation outside national or international regulation for in vitro diagnostic testing, little evidence of quality as well as the risk of transfer of genetic materials from the companies to other entities. Another... International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5415398 Thu, 17 Nov 2011 17:02:14 +0100 5415398 http://www.medworm.com/index.php?rid=5415397&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02803.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5415397 Thu, 17 Nov 2011 17:02:13 +0100 5415397 http://www.medworm.com/index.php?rid=5415396&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02762.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5415396 Thu, 17 Nov 2011 17:02:12 +0100 5415396 http://www.medworm.com/index.php?rid=5415395&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02804.x Linked Comment: Luo et al. Int J Clin Pract 2011; 65: 1313‐20. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5415395 Thu, 17 Nov 2011 17:02:10 +0100 5415395 http://www.medworm.com/index.php?rid=5415394&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02802.x Linked Comment: Andrey et al. Int J Clin Pract 2011; 65: 1250‐8. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5415394 Thu, 17 Nov 2011 17:02:09 +0100 5415394 http://www.medworm.com/index.php?rid=5394408&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02826.x SummaryCounterfeit medicines pose an ever‐increasing threat to public health, although precise tracking of illegal counterfeit prescription drug activity is difficult. Available data indicate that all types of medications have been targeted. Adverse health effects, including death, have resulted from using counterfeit medications; consumers who self‐medicate without appropriate interactions with the healthcare system rarely receive adequate healthcare. The Internet provides a large, convenient route for counterfeiters to reach potential buyers with unregulated, often dangerous, products. The majority of medicines purchased via unverified Internet sites are counterfeit; often, these products lack the purported drug compound or have variable concentrations of active ingredients and somet... International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5394408 Tue, 01 Nov 2011 04:00:00 +0100 5394408 http://www.medworm.com/index.php?rid=5371960&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02809.x SummaryVarious antiplatelet and anticoagulation options are available for stroke prevention in patients with atrial fibrillation (AF). Currently, it is unclear whether these agents differ in their propensity to cause major gastrointestinal bleeding (MGIB). To our knowledge, no systematic evaluation of MGIB rates from randomised controlled trials (RCTs) of pharmacological stroke prevention in patients with AF has been conducted. Two independent investigators conducted systematic literature searches in MEDLINE and CENTRAL from the earliest possible date through November 2010. To be included, RCTs had to evaluate an adult population with AF or flutter and report data on the incidence of MGIB. Peto’s odds ratios (ORs) with associated 95% confidence intervals (CIs) were calculated for all pos... International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5371960 Tue, 01 Nov 2011 04:00:00 +0100 5371960 http://www.medworm.com/index.php?rid=5341967&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02820.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5341967 Sun, 23 Oct 2011 17:53:40 +0100 5341967 http://www.medworm.com/index.php?rid=5320081&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02754.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5320081 Sun, 16 Oct 2011 04:39:29 +0100 5320081 http://www.medworm.com/index.php?rid=5320080&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02772.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5320080 Sun, 16 Oct 2011 04:39:28 +0100 5320080 http://www.medworm.com/index.php?rid=5320079&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02764.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5320079 Sun, 16 Oct 2011 04:39:26 +0100 5320079 http://www.medworm.com/index.php?rid=5320078&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02741.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5320078 Sun, 16 Oct 2011 04:39:24 +0100 5320078 http://www.medworm.com/index.php?rid=5320077&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02759.x Conclusion:  In this study, doxazosin‐GITS showed significantly more rapid onset of efficacy and similar AEs compared with tamsulosin in BPH patients with LUTS. We believe this will probably improve patient compliance. Future studies with a larger number of patients and a longer follow‐up period will be required to confirm this. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5320077 Sun, 16 Oct 2011 04:39:22 +0100 5320077 http://www.medworm.com/index.php?rid=5320076&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02799.x Conclusions:  This review highlights the poor prognosis of patients with CRPC, and demonstrates a survival of 9–13 months in those patients with metastatic CRPC. Furthermore, progression to CRPC is associated with deterioration in quality of life, and few therapeutic options are currently available to patients with CRPC. However, epidemiologic study of these patients is hampered by differing terminology, definitions and treatment paradigms. Our review highlights the need for further well‐designed, epidemiological studies of CRPC, using standardised definitions and methods. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5320076 Sun, 16 Oct 2011 04:39:20 +0100 5320076 http://www.medworm.com/index.php?rid=5320075&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02732.x Conclusions:  This is the first study analysing long‐term effects of CRT in a homogeneous population of patients with non‐ischaemic dilated cardiomyopathy, indicating the favourable role of this non‐pharmacological therapy on the prevention of AF. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5320075 Sun, 16 Oct 2011 04:39:13 +0100 5320075 http://www.medworm.com/index.php?rid=5320074&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02779.x Conclusion:  To the extent that simvastatin 40 mg, rosuvastatin 10 mg and simvastatin/ezetimibe 10/10 mg are associated with adverse effects on insulin resistance, they appear to be of the same magnitude. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5320074 Sun, 16 Oct 2011 04:39:11 +0100 5320074 http://www.medworm.com/index.php?rid=5320073&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02766.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5320073 Sun, 16 Oct 2011 04:39:07 +0100 5320073 http://www.medworm.com/index.php?rid=5320072&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02780.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5320072 Sun, 16 Oct 2011 04:39:06 +0100 5320072 http://www.medworm.com/index.php?rid=5320071&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02770.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5320071 Sun, 16 Oct 2011 04:39:04 +0100 5320071 http://www.medworm.com/index.php?rid=5320070&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02819.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5320070 Sun, 16 Oct 2011 04:39:02 +0100 5320070 http://www.medworm.com/index.php?rid=5320069&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02769.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5320069 Sun, 16 Oct 2011 04:39:00 +0100 5320069 http://www.medworm.com/index.php?rid=5320068&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02807.x Conclusions:  Efficacy results were consistent with the ARTEN study demonstrating that NVP was non‐inferior to ATV/r when taken in combination with TDF/FTC. Rates of AEs were similar between the two arms, whereas HDL‐C increased and TC:HDL‐C decreased significantly more in patients taking NVP than ATV/r. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5320068 Sun, 16 Oct 2011 04:38:53 +0100 5320068 http://www.medworm.com/index.php?rid=5300892&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02812.x Conclusions:  Saxagliptin 2.5 mg once daily offers sustained efficacy and good tolerability for patients with T2DM and renal impairment. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5300892 Sat, 01 Oct 2011 04:00:00 +0100 5300892 http://www.medworm.com/index.php?rid=5266754&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02797.x Conclusions:  In Muslim patients with type 2 diabetes who observed the fast during Ramadan, switching to a sitagliptin‐based regimen decreased the risk of hypoglycaemia compared with remaining on a sulphonylurea‐based regimen. The incidence of hypoglycaemia was lower with gliclazide relative to the other sulphonylurea agents and similar to that observed with sitagliptin. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5266754 Fri, 30 Sep 2011 04:17:07 +0100 5266754 http://www.medworm.com/index.php?rid=5256082&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02789.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5256082 Mon, 26 Sep 2011 18:53:06 +0100 5256082 http://www.medworm.com/index.php?rid=5256085&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02742.x Conclusion:  Our data shows that the analysed rules perform equally well among elderly people with CAP which supports the recommendation for using the simplified CRB‐65 severity score among elderly patients in primary care or emergency visits. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5256085 Mon, 26 Sep 2011 04:00:00 +0100 5256085 http://www.medworm.com/index.php?rid=5256084&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02765.x Conclusions:  Effects from the RCT study were replicated and the effect on patients’ Qol was now significant. However, at 6‐month follow‐up, scores returned to baseline levels, indicating the need for some form of a booster session. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5256084 Mon, 26 Sep 2011 04:00:00 +0100 5256084 http://www.medworm.com/index.php?rid=5256083&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02767.x Conclusion:  A diagnosis of IC/PBS can be made without cystoscopic hydrodistention in women with increased bladder sensation, having storage symptoms, a CBC ≤ 350 ml, a positive KCl test result and a VAS score ≥ 2. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5256083 Mon, 26 Sep 2011 04:00:00 +0100 5256083 http://www.medworm.com/index.php?rid=5231186&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02709.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5231186 Mon, 19 Sep 2011 16:20:26 +0100 5231186 http://www.medworm.com/index.php?rid=5231185&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02745.x Linked Comment: Robles et al. Int J Clin Pract 2011; 65: 1108‐9. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5231185 Mon, 19 Sep 2011 16:20:25 +0100 5231185 http://www.medworm.com/index.php?rid=5231184&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02727.x Linked Comment: Bevc et al. Int J Clin Pract 2011; 65: 1109‐10. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5231184 Mon, 19 Sep 2011 16:20:23 +0100 5231184 http://www.medworm.com/index.php?rid=5231183&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02740.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5231183 Mon, 19 Sep 2011 16:20:21 +0100 5231183 http://www.medworm.com/index.php?rid=5231182&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02750.x Conclusion:  Delayed referral to a renal specialist adversely affects patient outcomes. This study suggests that the implementation of a virtual renal clinic for non‐complex renal pathologies can offer a cost‐effective, rapid referral mechanism for patient assessment combined with readily available specialist advice. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5231182 Mon, 19 Sep 2011 16:20:20 +0100 5231182 http://www.medworm.com/index.php?rid=5231181&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02756.x Conclusions:  This study showed that culture matters with respect to sexual counselling for cardiac patients. Interventions should be developed improving sexual counselling of cardiac patients. Educational courses and training of healthcare professionals on sexual counselling should be more sensitive to sociocultural differences. Cross‐cultural perspectives may bias attitudes of professionals as they deal with concerns of cardiac patients about resuming sexual activity. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5231181 Mon, 19 Sep 2011 16:20:18 +0100 5231181 http://www.medworm.com/index.php?rid=5231180&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02755.x Conclusions:  In type 2 diabetics with secondary SU failure, clinical parameters such as duration of diabetes (< 10 years), SU dose ( ≤ 4 mg) and BMI should be taken into consideration as important factors than laboratory indices related to β‐cell function when predicting the response to insulin analogues. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5231180 Mon, 19 Sep 2011 16:20:15 +0100 5231180 http://www.medworm.com/index.php?rid=5231179&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02707.x Conclusions:  Point of care glucose was significantly lower during the Rosh Hashanah period relative to preholiday and postholiday values. This may reflect a shift in the composition of the hospitalised patient population during the holidays towards older individuals with more restricted dietary intake. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5231179 Mon, 19 Sep 2011 16:20:10 +0100 5231179 http://www.medworm.com/index.php?rid=5231178&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02758.x Conclusions:  These data confirm that relapse is common and that as the variety of cessation modalities increase, the proportion of unassisted quit attempts decreases. Self‐help or cold‐turkey methods still provide significant alternatives even when pharmacotherapy is available. This study provides data related to the smoking history and smoking cessation patterns of a large, nationally representative sample of CS and FS. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5231178 Mon, 19 Sep 2011 16:20:08 +0100 5231178 http://www.medworm.com/index.php?rid=5231177&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02763.x SummaryA panel of experts in urology, urogynecology, nursing, and behavioral therapy convened in 2010 to discuss the importance of a healthy bladder on overall health. They determined that a consensus statement was necessary to raise awareness among the general public, healthcare providers, payors, and policymakers, with the goals of minimizing the impact of poor bladder health and stimulating primary prevention of bladder conditions. In this statement, ‘healthy’ bladder function is described, as well as internal and external factors that influence bladder health. It is suggested that primary prevention strategies should be aimed at providing education regarding normal lower urinary tract structures and functioning to the public, including patients and healthcare providers. This educat... International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5231177 Mon, 19 Sep 2011 16:20:05 +0100 5231177 http://www.medworm.com/index.php?rid=5231176&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02777.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5231176 Mon, 19 Sep 2011 16:20:00 +0100 5231176 http://www.medworm.com/index.php?rid=5202076&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02778.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5202076 Thu, 01 Sep 2011 04:00:00 +0100 5202076 http://www.medworm.com/index.php?rid=5153274&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02753.x SummaryStatins are a cornerstone in reducing cardiovascular events. Studies show that statins are beneficial even in patients with normal or low cholesterol levels, indicating pleiotropic mechanisms of therapeutic benefit apart from their antihyperlipidemic effect. Non‐randomised, observational and retrospective studies suggest that statins are associated with better outcomes in patients with heart failure (HF) of both ischaemic and non‐ischaemic aetiologies. While cholesterol reduction and plaque stabilisation likely play a role in reducing cardiovascular events in ischaemic HF patients, the mechanisms underlying the benefit in non‐ischaemic HF patients is less clear. This review suggests the pleiotropic effects of statin therapy can beneficially alter the pathophysiological mechani... International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5153274 Thu, 25 Aug 2011 00:23:56 +0100 5153274 http://www.medworm.com/index.php?rid=5136643&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02761.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5136643 Wed, 17 Aug 2011 14:18:08 +0100 5136643 http://www.medworm.com/index.php?rid=5136642&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02748.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5136642 Wed, 17 Aug 2011 14:18:06 +0100 5136642 http://www.medworm.com/index.php?rid=5136641&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02747.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5136641 Wed, 17 Aug 2011 14:18:05 +0100 5136641 http://www.medworm.com/index.php?rid=5136640&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02752.x Linked Comment: Chao. Int J Clin Pract 2011; 65: 1014. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5136640 Wed, 17 Aug 2011 14:18:04 +0100 5136640 http://www.medworm.com/index.php?rid=5136639&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02744.x Linked Comment: Cowie and Lucas. Int J Clin Pract 2011; 65: 1014‐5. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5136639 Wed, 17 Aug 2011 14:18:03 +0100 5136639 http://www.medworm.com/index.php?rid=5136638&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02728.x Discussion and conclusion:  Discontinuation of antimuscarinic therapy resulted in high symptom relapse and retreatment rates regardless of treatment duration. The results provide new information on the durability of the efficacy of antimuscarinics, and may improve treatment efficacy by promoting the medication persistence of antimuscarinics in OAB patients. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5136638 Wed, 17 Aug 2011 14:18:00 +0100 5136638 http://www.medworm.com/index.php?rid=5136637&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02746.x In conclusion, improving adherence to antidepressants requires a complex behavioural change and there is some evidence to support behavioural and multifaceted interventions as the most effective in improving antidepressant medication adherence and depression outcomes. More carefully designed and well‐conducted studies are needed to clarify the effect of interventions in different patient populations and treatment settings. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5136637 Wed, 17 Aug 2011 14:17:53 +0100 5136637 http://www.medworm.com/index.php?rid=5136636&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02743.x Conclusion:  In this matched‐cohort analysis, patients with schizophrenia who were considered to be non‐adherent with their prior oral antipsychotics were less likely to discontinue their medication for any cause if they were initiated on depot compared with oral antipsychotics. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5136636 Wed, 17 Aug 2011 14:17:49 +0100 5136636 http://www.medworm.com/index.php?rid=5136635&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02717.x Conclusions:  Trying to capture the overall inflammatory activity, in addition to the mass of adipose tissue, could provide useful hints towards a pathogenetic link between obesity and presence of cardiovascular disease. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5136635 Wed, 17 Aug 2011 14:17:47 +0100 5136635 http://www.medworm.com/index.php?rid=5136634&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02749.x Conclusion:  Improvements in glycaemic control were greater with SITA/MET vs. PIO, with weight loss vs. weight gain. Both treatments were generally well tolerated. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5136634 Wed, 17 Aug 2011 14:17:45 +0100 5136634 http://www.medworm.com/index.php?rid=5136633&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02737.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5136633 Wed, 17 Aug 2011 14:17:42 +0100 5136633 http://www.medworm.com/index.php?rid=5136632&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02757.x Linked Comment: Weiss et al. Int J Clin Pract 2011; 65: 939‐44. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5136632 Wed, 17 Aug 2011 14:17:40 +0100 5136632 http://www.medworm.com/index.php?rid=5136631&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02760.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5136631 Wed, 17 Aug 2011 14:17:38 +0100 5136631 http://www.medworm.com/index.php?rid=5084401&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02729.x Conclusions:  We found confirmation that the commonest sexual complaints in men were of erectile dysfunction and loss of sex drive. Significant correlations were identified between the types of sexual dysfunction and the age and ethnicity of the men who presented with them. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5084401 Sun, 31 Jul 2011 23:00:00 +0100 5084401 http://www.medworm.com/index.php?rid=5084400&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02751.x Conclusion:  Until we have more evidence on the safety and efficacy of e‐cigs for smoking cessation, smokers should be advised to use proven treatments (e.g. counselling and FDA‐approved medicines). However, for those who have successfully switched to e‐cigs, the priority should be staying off cigarettes, rather than quitting e‐cigs. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5084400 Sun, 31 Jul 2011 23:00:00 +0100 5084400 http://www.medworm.com/index.php?rid=5084399&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02734.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5084399 Sun, 31 Jul 2011 23:00:00 +0100 5084399 http://www.medworm.com/index.php?rid=5084398&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02739.x Conclusions:  There is a wide margin for improvement in the adaptation of clinical practice to recommendations for diabetic patients. The large variation existing in certain indicators would suggest that certain control objectives are less demanding than advisable in those that comply least, while low compliance and low variability in other indicators point to structural problems or unsatisfactory training of doctors. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5084398 Sun, 31 Jul 2011 23:00:00 +0100 5084398 http://www.medworm.com/index.php?rid=5046481&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02718.x This article extensively reviews various aetiologies and management of adrenal insufficiency. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5046481 Thu, 21 Jul 2011 21:50:41 +0100 5046481 http://www.medworm.com/index.php?rid=5025707&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02733.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5025707 Thu, 14 Jul 2011 17:59:57 +0100 5025707 http://www.medworm.com/index.php?rid=5025708&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02705.x This study has identified where there are weaknesses in our hospital opioid prescribing practice and has aided us in rewriting our acute and chronic pain guidelines with the explicit inclusion of the National Patient Safety Agency recommendations. We have also disseminated the study results at the Trust academic meeting and developed an opioid e‐learning package which will be mandatory for all new staff. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5025708 Tue, 12 Jul 2011 23:00:00 +0100 5025708 http://www.medworm.com/index.php?rid=5004670&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02726.x SummaryPulmonary arterial hypertension (PAH) is a clinical condition characterised by the presence of precapillary pulmonary hypertension (PH). Included within the subcategorisation of PAH are heritable (HPAH) and PAH associated various conditions (APAH) including systemic sclerosis (SSc). The pathogenesis of HPAH and SSc has been linked to both a genetic predisposition and epigenetic factors. TGF‐β superfamily signalling has also been implicated in the development of these conditions. In this review, we discuss the role of genetic predisposition, epigenetic factors along with dysregulation in TGF‐β superfamily signalling in the pathogenesis of PAH and SSc. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5004670 Thu, 07 Jul 2011 19:12:50 +0100 5004670 http://www.medworm.com/index.php?rid=5004669&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02710.x SummaryThe WHO classification of pulmonary hypertension (PH) recognises five distinct groups, all sharing a mean, resting, pulmonary artery pressure (PAP) > 25 mmHg. The aetiology of PH varies by group (1‐pulmonary vascular disease, 2‐high left heart filling pressures, 3‐hypoxia, 4‐unresolved pulmonary embolism and 5‐miscellaneous). Inclusion in a group reflects shared histological, haemodynamic and pathophysiological features and has therapeutic implications. Advantages of using rodent models to understand the pathophysiology of human PH and to test experimental therapies include the economy, safety and mechanistic certainty they provide. As rodent models are meant to reflect human PH, they should be categorised by a parallel PH classification and limitations in achieving... International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5004669 Thu, 07 Jul 2011 19:12:50 +0100 5004669 http://www.medworm.com/index.php?rid=5004668&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02711.x SummaryPulmonary arterial hypertension (PAH) is a complex disorder in which pulmonary arterial obstruction leads to elevated pulmonary arterial resistance and right ventricular failure. Normal physiologic changes that occur during pregnancy and immediately postpartum may produce fatal consequence in PAH patients. Pregnancy in patients with PAH has a high maternal mortality, estimated at 30–56%. Contemporary estimates of mortality are better but still prohibitively high. Current guidelines recommend that pregnancy be avoided or terminated early in women with PAH. Some patients, despite counselling by their physician, choose to continue with their pregnancy. In addition, some women first present with PAH during pregnancy leading to complex management issues in a high‐risk patient. PAH‐... International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5004668 Thu, 07 Jul 2011 19:12:49 +0100 5004668 http://www.medworm.com/index.php?rid=5004667&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02725.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5004667 Thu, 07 Jul 2011 19:12:49 +0100 5004667 http://www.medworm.com/index.php?rid=5004666&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02712.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5004666 Thu, 07 Jul 2011 19:12:48 +0100 5004666 http://www.medworm.com/index.php?rid=5004665&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02735.x Conclusions:  A diagnostic algorithm including only objective variables (age, IPSS and PSA), easily implemented in any GP office, allows GPs to accurately diagnose BPH in approximately three‐quarters of patients spontaneously reporting LUTS. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5004665 Thu, 07 Jul 2011 19:12:43 +0100 5004665 http://www.medworm.com/index.php?rid=4990286&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02703.x Conclusions:  Composite measures can play an important role in characterising heterogeneity of treatment response and outcome in patients suffering from various medical conditions. These measures can help clinicians to better distinguish between patients with high likelihood to respond well to treatment and patients with minimal chances of positive therapeutic outcomes. Herein, the individual factors identified can be used to develop novel predictive or prognostic composite measures that can be applicable across disease areas. Reflecting these cross‐disease measures in clinical and public health decisions has the distinctive appeal to enable targeted treatment for patients suffering from multiple medical conditions, which may ultimately yield significant gains in individual outcomes, p... International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=4990286 Thu, 30 Jun 2011 23:00:00 +0100 4990286 http://www.medworm.com/index.php?rid=4990285&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02688.x Conclusion:  Chronic catarrh appears to be related more to pharyngeal symptom awareness than to pathological postnasal drip or mucus over‐production. Rhinological investigations have a limited role in the management of chronic catarrh patients. The principal outcome of ENT referral is likely to be reassurance and direction towards patient self‐help information. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=4990285 Thu, 30 Jun 2011 23:00:00 +0100 4990285 http://www.medworm.com/index.php?rid=4990284&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02731.x SummaryBenign prostatic hyperplasia (BPH) is a common disease in older men that can lead to lower urinary tract symptoms (LUTS). Male sexual dysfunction is also an age‐related condition. Epidemiological studies have confirmed an association between BPH/LUTS and sexual dysfunction in ageing men that is independent of the effects of age, other co‐morbidities and lifestyle factors. Proposed pathophysiological mechanisms for BPH/LUTS‐associated sexual dysfunction include the nitric oxide/cyclic guanosine monophosphate (NO/cGMP) pathway, rho‐kinase and endothelin‐1 activity, autonomic nervous system overactivity and the metabolic syndrome, and pelvic organ atherosclerosis. Both BPH/LUTS and sexual dysfunction can have a substantial negative impact on a man’s quality of life. However... International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=4990284 Thu, 30 Jun 2011 23:00:00 +0100 4990284 http://www.medworm.com/index.php?rid=4966297&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02736.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=4966297 Sun, 26 Jun 2011 15:14:59 +0100 4966297 http://www.medworm.com/index.php?rid=4930362&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02724.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=4930362 Thu, 16 Jun 2011 16:49:00 +0100 4930362 http://www.medworm.com/index.php?rid=4930360&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02701.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=4930360 Thu, 16 Jun 2011 16:48:59 +0100 4930360 http://www.medworm.com/index.php?rid=4930359&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02692.x Linked Comment: Haynes. Int J Clin Pract 2011; 65: 817. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=4930359 Thu, 16 Jun 2011 16:48:58 +0100 4930359 http://www.medworm.com/index.php?rid=4930358&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02687.x Linked Comment: Ernst. Int J Clin Pract 2011; 65: 818. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=4930358 Thu, 16 Jun 2011 16:48:58 +0100 4930358 http://www.medworm.com/index.php?rid=4930357&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02693.x Conclusion:  Only a minority of men with erectile dysfunction have a previously undiagnosed important underlying disease that is uncovered at the time of an initial PDE5i prescription by a GP. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=4930357 Thu, 16 Jun 2011 16:48:56 +0100 4930357 http://www.medworm.com/index.php?rid=4930356&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02704.x SummaryThe aim of this study was to review the application of antimicrobial stewardship principles to the management of community‐acquired pneumonia (CAP). Data from 14 published clinical studies, meta‐analyses and practice guidelines regarding the application of antimicrobial stewardship strategies to the management of CAP were identified and analysed. In the context of CAP, application of stewardship strategies (alone or in combination) has been shown to increase physician awareness of guidelines, improve appropriate antimicrobial use and reduce unnecessary antimicrobial prescribing. In addition, application has had a profound favourable impact on patient outcomes, including decreased 30‐day mortality and in‐hospital mortality rates, reduced length of hospital stay, reduced treat... International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=4930356 Thu, 16 Jun 2011 16:48:55 +0100 4930356 http://www.medworm.com/index.php?rid=4930355&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02685.x Conclusions:  The results of the indirect comparison support the hypothesis that budesonide/formoterol is associated with fewer pneumonia events than salmeterol/fluticasone in chronic obstructive pulmonary disease. The limitations of the analysis are that the results from a single study, TORCH, have a large bearing on the overall findings of the analysis, and that there is heterogeneity in the length and the dosing of the included studies, although it does not appear that heterogeneity affected the reported results. Another important limitation is the lack of predefined diagnostic standards for pneumonia in these studies. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=4930355 Thu, 16 Jun 2011 16:48:54 +0100 4930355 http://www.medworm.com/index.php?rid=4930354&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02694.x SummaryWarfarin significantly reduces thromboembolic risk, but perceptions of associated bleeding risk limit its use. The evidence supporting the association between bleeding and individual patient risks factors is unclear. This systematic review aims to determine the strength of evidence supporting an accentuated bleeding risk when patients with risk factors listed in the warfarin prescribing information are prescribed the drug. A systematic literature search of MEDLINE and Cochrane CENTRAL was conducted to identify studies reporting multivariate relationships between prespecified covariates and the risk of bleeding in patients receiving warfarin. The prespecified covariates were identified based on patient characteristics for bleeding listed in the warfarin package insert. Each covariate... International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=4930354 Thu, 16 Jun 2011 16:48:54 +0100 4930354 http://www.medworm.com/index.php?rid=4930353&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02706.x Conclusion:  These findings carry an implication that younger subjects, new patients, visitors in clinics other than FMSC and those without comorbidities should receive more meticulous monitoring of their medication‐taking behaviour. Future studies should evaluate the major reasons for non‐adherence among them. (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=4930353 Thu, 16 Jun 2011 16:48:53 +0100 4930353 http://www.medworm.com/index.php?rid=4930352&cid=s_38731_49_f&fid=38731&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-1241.2011.02696.x (Source: International Journal of Clinical Practice) International Journal of Clinical Practice journals http://www.medworm.com/rss/comments.php?id=4930352 Thu, 16 Jun 2011 16:48:52 +0100 4930352