MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'International Journal of Hematology' source. Wed, 17 Mar 2010 14:33:30 +0100 http://www.medworm.com/index.php?rid=3363309&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20224872%26dopt%3DAbstract Authors: Nakane T, Nakamae H, Koh H, Nakamae M, Aimoto R, Terada Y, Koh KR, Yamane T, Hino M Side effects of varying severity are frequent in peripheral blood stem cell harvest (PBSCH). Life-threatening complications associated with PBSCH have also been reported. Heart rate variability (HRV), which reflects sympathovagal balance and autonomic cardiovascular control, has been a subject of intense interest in various diseases precipitating sudden death. Here, we prospectively assessed the impact of leukapheresis on HRV among autologous hematopoietic cell transplant patients and healthy donors. We found that HRV indicators, the standard deviation of normal-to-normal intervals (SDNN) value, the square root of the mean of the sum of squared differences between the adjacent normal-to-normal ... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3363309 Fri, 12 Mar 2010 00:00:00 +0100 3363309 http://www.medworm.com/index.php?rid=3363308&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20224873%26dopt%3DAbstract This report exemplified a success of unrelated donor cord blood transplantation (CBT) in a 4-month-old boy with chronic granulomatous disease (CGD). Following Bu14/Cy200/ATG conditioning, the patient received an HLA 2-locus-mismatched cord blood unit, and the total number of infused nucleated cells was 11.52 x 10(7)/kg. Neutrophil engraftment was achieved on day +13, and a platelet count greater than 20 x 10(9)/L was achieved on day +50. The neutrophil oxidative burst was 100% normal with full donor lymphocyte reconstitution at 8 months post-transplant. This case highlights that unrelated donor CBT for CGD is potentially safe and feasible, even in early infancy, when an appropriately matched related or unrelated donor is unavailable. PMID: 20224873 [PubMed - as supplied by publisher] (... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3363308 Fri, 12 Mar 2010 00:00:00 +0100 3363308 http://www.medworm.com/index.php?rid=3363307&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20224874%26dopt%3DAbstract Authors: Kitagawa M, Era T The pluripotency of embryonic stem cells has been well demonstrated by a vast variety of studies showing the induction of differentiation into desired cell types that have the potential to be used not only in basic studies but also in medical applications. The induction of mesodermal cells, especially blood cells, from embryonic stem cells is notable from the point of view of transplantation, and the methods for this induction have improved over the last few years, with more defined culture conditions in place. Concurrently, the generation of induced pluripotent stem cells from somatic cells opens the possibility of autologous transplantation. In fact, there are a growing number of reports demonstrating that several mesodermal cells can be differentiated from... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3363307 Fri, 12 Mar 2010 00:00:00 +0100 3363307 http://www.medworm.com/index.php?rid=3359229&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20217283%26dopt%3DAbstract We report a case of a 41-year-old male with human immunodeficiency virus (HIV)-associated lymphoproliferative disease (LPD) who was successfully treated with highly active antiretroviral therapy (HAART). He presented with epigastralgia, and an upper endoscopic examination revealed submucosal tumors and ulcerations in his stomach. Histopathologic examination of a biopsy specimen resulted in a diagnosis of diffuse large B-cell lymphoma. He also showed systemic lymphadenopathy; whereas, a concurrent inguinal lymph node biopsy produced a diagnosis of follicular hyperplasia. He was treated with CHOP chemotherapy but the response was poor. He demonstrated several immunological abnormalities, such as eosinophilia and bone marrow insufficiency, and was suspected to be in an immunocompromised state... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3359229 Wed, 10 Mar 2010 00:00:00 +0100 3359229 http://www.medworm.com/index.php?rid=3359223&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20217284%26dopt%3DAbstract Deep vein and intracardiac thrombosis during the post-partum period in Behçet's disease. Int J Hematol. 2010 Mar 10; Authors: Hiwarkar P, Stasi R, Sutherland G, Shannon M A 22-year-old woman presented on the 10th post-partum day with deep vein thrombosis involving the right ilio-femoral and popliteal veins. This thrombosis was refractory to conventional anticoagulation and subsequently over a period of 6 weeks progressed to involve inferior vena cava and right ventricle. A diagnosis of Behçet's disease was made on the clinical grounds of fever, night sweats, and recurrent oral ulcers. In view of refractory thrombosis, anticoagulation with lepirudin was commenced followed by thrombolysis with streptokinase. After thrombolysis, anticoagulation was switched to fondaparin... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3359223 Wed, 10 Mar 2010 00:00:00 +0100 3359223 http://www.medworm.com/index.php?rid=3359222&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20217285%26dopt%3DAbstract We report a case of prolonged severe hypogammaglobulinemia after rituximab combined chemotherapy for follicular lymphoma. Although the patient's globulin level was within the normal limits before treatment, the level of IgG dropped below 100 mg/dL, and both IgA and IgM became undetectable after treatment, and the levels have shown no changes for 6 years despite recovery of peripheral B cell counts. Phenotypic analysis of B cells revealed a reduction of class-switched CD27+IgM-IgD- memory B cells below 0.5% and overexpression of CD95. On the other hand, we observed the predominance of memory T cell subsets in both of CD4+ and CD8+ T cells as the result of reduction of naïve T cells. These increased memory T cells overexpressed activation markers such as CD69, CD95, and HLA-DR. Furtherm... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3359222 Wed, 10 Mar 2010 00:00:00 +0100 3359222 http://www.medworm.com/index.php?rid=3359220&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20217286%26dopt%3DAbstract We report a 23-year-old virgin female with Fanconi's anemia and diabetes mellitus who presented with a history of 6-month ulcerative lesions of the vulva. Gynecologic examination disclosed a 1 x 2 cm ulcerated tumor lesion at the right labia minor near to the urethra. The biopsy showed a high-grade vulvar intraepithelial neoplasia (VIN III). She underwent wide local excision for this lesion. Pathologic examination of the surgically removed specimen revealed SCC of the vulva. Therefore, radical vulvectomy and bilateral inguino-femoral lymphadenectomy were performed. Due to the involvement of right inguinal lymph node, radiotherapy with a total dose of 45 Gy was delivered to mid-pelvis through antero-posterior/postero-anterior fields with 18 mV photon energies. Until her last follow-up about... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3359220 Wed, 10 Mar 2010 00:00:00 +0100 3359220 http://www.medworm.com/index.php?rid=3359219&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20217287%26dopt%3DAbstract We describe herein the clinical courses and outcomes of 26 patients who received oral mycophenolate mofetil (MMF) for the treatment of steroid-resistant refractory or steroid-dependent acute or chronic graft-versus-host disease (GVHD) in a single institution. In most cases, 1,500 mg/day of MMF is a median dose (range 500-3,000 mg/day) and administered for 116.5 days (range 9-584 days) along with calcineurin inhibitors and steroids. Although 20 patients (77%) showed rapid improvement of GVHD symptoms, of 15 patients, 13 (87%) showed acute GVHD; of 11 patients, 7 (64%) showed chronic GVHD; most patients (54%) experienced infection during MMF administration, including 5 cases with life-threatening infection. Positive cytomegalovirus (CMV) antigenemia was also observed in 19 patients (73%), bu... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3359219 Wed, 10 Mar 2010 00:00:00 +0100 3359219 http://www.medworm.com/index.php?rid=3359217&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20217288%26dopt%3DAbstract Authors: Asano N, Suzuki R, Ohshima K, Kagami Y, Ishida F, Yoshino T, Ogawa H, Morishima Y, Nakamura S Peripheral T cell lymphoma not otherwise specified (PTCL-N) and ALK-negative anaplastic large cell lymphoma (ALCL) are heterogeneous categories with poor diagnostic reproducibility. To clarify the biologic features of these categories, we investigated the expression of two chemokine receptors, type 1 (Th1/Tc1)-associated CXCR3 and type 2 (Th2/Tc2)-associated CCR4 in 110 PTCL-N and 35 ALK-negative ALCL cases, as well as the expression of cytotoxic molecules (CM). CXCR3 and CCR4 were expressed in 69 (63%) and 37 (34%) of PTCL-N, and in 12 (34%) and 6 (17%) of ALK-negative ALCL, respectively. In PTCL-N, type 1 pattern (CXCR3(+)CCR4(-)) was dominant (52%), whereas in ALK-negative ALCL, 54... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3359217 Tue, 09 Mar 2010 00:00:00 +0100 3359217 http://www.medworm.com/index.php?rid=3350701&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20213115%26dopt%3DAbstract Authors: Romani C, Murru R, Pettinau M, Di Tucci AA, Culurgioni F, Pulisci D, Angelucci E PMID: 20213115 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3350701 Tue, 09 Mar 2010 00:00:00 +0100 3350701 http://www.medworm.com/index.php?rid=3350699&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20213117%26dopt%3DAbstract Authors: Kulkarni K, Kaur S, Sibal A, Jerath N, Arya LS PMID: 20213117 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3350699 Tue, 09 Mar 2010 00:00:00 +0100 3350699 http://www.medworm.com/index.php?rid=3350698&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20213118%26dopt%3DAbstract Authors: Huang XP, Thiessen JJ, Spino M, Templeton DM Iron chelators are effective at removing iron from the body in iron overload, but little is known about the handling of iron chelates by the kidney. We studied the transport of deferoxamine, deferasirox, and three hydroxypyridones, and their iron chelates, in polarized renal epithelial MDCK cells growing on Transwell inserts. Directional iron efflux was also studied in (59)Fe-loaded cells. The chelators were transported at comparable rates in the apical and basolateral directions and moved faster than their corresponding chelates, except for deferoxamine, which did not move from the basolateral to the apical side. In contrast, the chelates were transported faster in the apical-to-basolateral direction. More permeable chelators were ... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3350698 Tue, 09 Mar 2010 00:00:00 +0100 3350698 http://www.medworm.com/index.php?rid=3350700&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20213116%26dopt%3DAbstract Authors: Savas N, Turhan E, Inandi T, Kaya H Hemoglobinopathy is a major public health problem in Eastern Mediterranean, Turkey, where homozygote babies continue to be born. We wanted to present the knowledge of high school students and their attitudes on hemoglobinopathy in Antakya (center of Hatay).The study was performed on 11th grade students in 17 high schools and 486 students in the center at Antakya. We used a questionnaire and frequency tables and chi-square tests were used. Of the students who took part, 37.7% were previously informed about hemoglobinopathies, while 62.3% were not. There was no significant relationship between the school types and their being previously informed (p > 0.05). There was an index case for 28% of the students, and 25.4% of the students who did n... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3350700 Sat, 06 Mar 2010 00:00:00 +0100 3350700 http://www.medworm.com/index.php?rid=3332073&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20198459%26dopt%3DAbstract Authors: Chuang SS, Ichinohasama R, Chu JS, Ohshima K Angioimmunoblastic lymphoma (AITL) is a nodal peripheral T-cell lymphoma characterized by a proliferation of arborizing vessels and hyperplastic follicular dendritic cells as well as a polymorphous lymphoid infiltrate including neoplastic cells with clear cytoplasm. Adult T-cell leukemia/lymphoma (ATLL) is caused by the retrovirus human T-cell leukemia virus type I (HTLV-I), and the neoplastic cells are usually large and pleomorphic. Recently, a rare morphologic variant of ATLL with AITL-like features has been reported. Here, we presented a case of peripheral T-cell lymphoma with morphological features of AITL in Taiwan, a country non-endemic for HTLV, and the patient was seropositive for anti-HTLV antibody, which raised the possibi... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3332073 Thu, 04 Mar 2010 00:00:00 +0100 3332073 http://www.medworm.com/index.php?rid=3332074&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20195929%26dopt%3DAbstract Authors: Muto H, Ohashi K, Ando M, Akiyama H, Sakamaki H We retrospectively reviewed the medical records of 75 allogeneic hematopoietic transplant recipients and evaluated cystatin C as a potential marker of subsequent renal dysfunction. Acute kidney injury developed in 31 of 75 patients after a median of 46 days post-transplantation (range 1-502 days), while worsening of chronic kidney disease (CKD) was observed in 21 patients during the observational period. Cystatin C level was significantly elevated after allogeneic transplantation (P < 0.001). Multivariate analysis revealed the use of calcineurin inhibitors as a major cause of cystatin C elevation (odds ratio 7.26, P = 0.04). A strong inverse correlation was also noted between cystatin C and estimated glomerular filtration rate... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3332074 Wed, 03 Mar 2010 00:00:00 +0100 3332074 http://www.medworm.com/index.php?rid=3332072&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20198460%26dopt%3DAbstract In conclusion, our comparison suggests that R-CHOP may increase response and reduce relapse resulting in prolongation of progression-free survival of patients with PMBCL. PMID: 20198460 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3332072 Wed, 03 Mar 2010 00:00:00 +0100 3332072 http://www.medworm.com/index.php?rid=3332071&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20198461%26dopt%3DAbstract Authors: Itoh K, Kinoshita T, Watanabe T, Yoshimura K, Okamoto R, Chou T, Ogura M, Hirano M, Asaoku H, Kurosawa M, Maeda Y, Omachi K, Moriuchi Y, Kasai M, Ohnishi K, Takayama N, Morishima Y, Tobinai K, Kaba H, Yamamoto S, Fukuda H, Kikuchi M, Yoshino T, Matsuno Y, Hotta T, Shimoyama M The Japan Clinical Oncology Group conducted two multicenter phase II trials in 200 patients with advanced Hodgkin lymphoma (HL) in the 1990s. Among 181 patients whose histopathological specimens were available and reviewed by 6 hematopathologists, 167 (92.3%) were diagnosed with HL. Five-year overall survival (OS) among these 167 patients was 88.3%, including 89.2% among nodular sclerosis and 82.2% among mixed cellularity cases. International prognostic score was not closely associated with OS. Seven unfa... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3332071 Wed, 03 Mar 2010 00:00:00 +0100 3332071 http://www.medworm.com/index.php?rid=3332075&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20195928%26dopt%3DAbstract Authors: Mori T, Aisa Y, Kato J, Nakamura Y, Shimizu T, Okamoto S PMID: 20195928 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3332075 Tue, 02 Mar 2010 00:00:00 +0100 3332075 http://www.medworm.com/index.php?rid=3323270&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20191331%26dopt%3DAbstract Authors: Hitoshi Y, Lin N, Payan DG, Markovtsov V Janus kinases (JAKs) are critical components of cytokine signaling pathways which regulate immunity, inflammation, hematopoiesis, growth, and development. The recent discovery of JAK2-activating mutations as a causal event in the majority of patients with Philadelphia chromosome negative (Ph-) myeloproliferative disorders (MPDs) prompted many pharmaceutical companies to develop JAK2-selective inhibitors for the treatment of MPDs. JAK2 inhibitors effectively reduce JAK2-driven phosphorylation of signal transducer and activator of transcription 5, and cell proliferation and cell survival in JAK2-activated cells in vitro and in vivo. Most inhibitors are currently being evaluated in patients with one form of MPD, myelofibrosis. Patients tre... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3323270 Sat, 27 Feb 2010 00:00:00 +0100 3323270 http://www.medworm.com/index.php?rid=3323269&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20191332%26dopt%3DAbstract Authors: Wadleigh M, Tefferi A The myeloproliferative neoplasms (MPNs) were first recognized by William Dameshek in 1951. The classic MPNs were polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF) and chronic myelogenous leukemia. They were originally grouped together based on their shared phenotype of myeloproliferation. Since then, important discoveries have been made, identifying a central role of protein tyrosine kinases in the pathogenesis of these disorders. As such, the 2008 WHO diagnostic classification for myeloproliferative neoplasms has incorporated molecular markers with histologic, clinical and laboratory information into the diagnostic algorithms for the MPNs. Important changes include (1) the change of nomenclature of myeloproliferative dis... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3323269 Sat, 27 Feb 2010 00:00:00 +0100 3323269 http://www.medworm.com/index.php?rid=3323268&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20191333%26dopt%3DAbstract We present two patients with chronic myelogenous leukemia in whom, following the development of symptomatic pleural effusion, medications were safely switched from dasatinib to nilotinib after a 1-month off-drug period. The lymphocytosis and increased large granular lymphocyte count observed during dasatinib treatment also subsided after switching medications. PMID: 20191333 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3323268 Sat, 27 Feb 2010 00:00:00 +0100 3323268 http://www.medworm.com/index.php?rid=3323267&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20191334%26dopt%3DAbstract Authors: Bedognetti D, Zoppoli G, Sertoli MR, Zanardi E, Blandini P, Uccellini L, Boccardo F, Andreoli GB, Ghio R, Racchi O, Ferrarini M, De Maria A PMID: 20191334 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3323267 Sat, 27 Feb 2010 00:00:00 +0100 3323267 http://www.medworm.com/index.php?rid=3313357&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20186505%26dopt%3DAbstract Authors: Delhommeau F, Jeziorowska D, Marzac C, Casadevall N During these past 5 years several studies have provided major genetic insights into the pathogenesis of the so-called classical myeloproliferative neoplasms (MPNs): polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). The discovery of the JAK2V617F mutation first, then of the JAK2 exon 12 and MPLW515 mutations, have modified the understanding of these diseases, their diagnosis, and management. Now it is established that almost 100% of PV patients present a JAK2 mutation. Nearly 60% of ET patients and 50% of patients with PMF have the JAK2V617F mutation. The MPLW515 mutations are also present in a small proportion of ET and PMF patients. These mutations are oncogenic events that cause these ... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3313357 Sat, 27 Feb 2010 00:00:00 +0100 3313357 http://www.medworm.com/index.php?rid=3313356&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20186506%26dopt%3DAbstract Authors: Kusumoto S, Tanaka Y PMID: 20186506 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3313356 Sat, 27 Feb 2010 00:00:00 +0100 3313356 http://www.medworm.com/index.php?rid=3307166&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20180052%26dopt%3DAbstract Authors: Hemmati PG, Terwey TH, Massenkeil G, le Coutre P, Vuong LG, Neuburger S, Dörken B, Arnold R To evaluate the efficacy of reduced intensity conditioning (RIC) prior to allogeneic stem cell transplantation (alloSCT) in patients with acute myeloid leukemia (AML) in first complete remission (CR1), we retrospectively analyzed the outcome of 93 consecutive patients transplanted at our institution either following RIC (n = 37) or standard myeloablative conditioning (MAC) (n = 56) between 1999 and 2007. Projected overall survival (OS) or disease-free survival (DFS) for all patients at 1, 2, and 5 years was 78 or 70%, 65 or 57%, and 61 or 53% in the RIC group versus 73 or 70%, 68 or 62%, and 56 or 54% in the standard MAC group. In the subgroup of patients with an intermediate-risk ... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3307166 Thu, 25 Feb 2010 00:00:00 +0100 3307166 http://www.medworm.com/index.php?rid=3307168&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20178012%26dopt%3DAbstract Authors: Rambaldi A Myelofibrosis shows a progressive clinical course and usually a poor, lethal prognosis. Allogeneic transplantation is an effective, potentially curable treatment approach although only a minority of patients may currently benefit from it. New effective treatment strategies are becoming available for this disease, including not only JAK2 inhibitors, but also other innovative drugs, targeting more general oncogenic mechanisms and the epigenetic control of cell proliferation and differentiation. PMID: 20178012 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3307168 Wed, 24 Feb 2010 00:00:00 +0100 3307168 http://www.medworm.com/index.php?rid=3307167&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20178013%26dopt%3DAbstract Authors: Ji Y, Zhang W, Wang J, Gu L XAGE-1 is a cancer-testis antigen, which was demonstrated to be expressed at a significant frequency and to be immunogenic in some solid tumors. We analyzed the expression of 4 XAGE-1 transcript variant gene in human acute leukemias by reverse-transcription polymerase chain reaction. Among the 114 acute leukemias, 14/63 (22.22%) of the acute myeloid leukemia samples were positive for XAGE-1b genes. XAGE-1b mRNA expression was detected in 10/51 (19.61%) of the acute lymphocyte leukemia samples. However, we did not find any important correlation between XAGE-1b mRNA expression and clinical characteristics, such as sex, leukemia type, response to therapy and the percentage of blast in the first diagnosed bone marrow. We concluded that the XAGE-1b gene ... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3307167 Wed, 24 Feb 2010 00:00:00 +0100 3307167 http://www.medworm.com/index.php?rid=3292223&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20169427%26dopt%3DAbstract Authors: Sakamoto H, Tsuji-Tamura K, Ogawa M Embryonic stem cells (ESCs) can differentiate into various types of hematopoietic cells (HPCs) when placed in an appropriate environment. Various methods for the differentiation of ESCs into specific HPC lineages have been developed using mouse ESCs. These ESC-differentiation methods have been utilized also as an in vitro model to investigate hematopoiesis in embryos and they provided critical perceptions into it. These methods have been adapted for use with human ESCs, which have the possibility of being employed in regenerative medicine; further improvement of these methods may lead to the efficient production of HPCs for use in transfusions. The generation of transplantable hematopoietic stem cells is a medical goal that is still difficul... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3292223 Sat, 20 Feb 2010 00:00:00 +0100 3292223 http://www.medworm.com/index.php?rid=3288583&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20162469%26dopt%3DAbstract Authors: Asada N, Ishii S, Wakahashi K, Kawano H, Kawamori Y, Nishikawa S, Minagawa K, Okamura A, Shimoyama M, Katayama Y, Hayashi Y, Itoh T, Tanimoto M, Matsui T A 26-year-old woman, who successfully underwent umbilical cord blood transplantation for aplastic anemia 4 years previously, had suffered from hepatosplenic microabscesses caused by unidentifiable grocott stain-positive spores from immediately after the transplantation. At 51 months post-transplant, we attempted bone marrow biopsy from her posterior iliac crest, but failed to penetrate the cortical bone. X-ray of her spine and pelvis showed marked and diffuse osteosclerosis. Retrospective analysis of computed tomography revealed the gradual replacement of sternal, vertebral, and pelvic bone marrow with calcified tissues in ad... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3288583 Wed, 17 Feb 2010 00:00:00 +0100 3288583 http://www.medworm.com/index.php?rid=3280708&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20155516%26dopt%3DAbstract Authors: Franklin BE, Oprea M, Franklin SM PMID: 20155516 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3280708 Tue, 16 Feb 2010 00:00:00 +0100 3280708 http://www.medworm.com/index.php?rid=3280707&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20157790%26dopt%3DAbstract Authors: Masui S Embryonic stem (ES) cells are derived from blastocysts and are pluripotent. This pluripotency has attracted the interest of numerous researchers, both to expand our fundamental understanding of developmental biology and also because of potential applications in regenerative medicine. Systems biological studies have demonstrated that the pivotal transcription factors form a network. There they activate pluripotency-associated genes, including themselves, while repressing the developmentally regulated genes through co-occupation with various protein complexes. The chromatin structure characteristic of ES cells also contributes to the maintenance of the network. In this review, I focus on recent advances in our understanding of the transcriptional network that maintains p... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3280707 Tue, 16 Feb 2010 00:00:00 +0100 3280707 http://www.medworm.com/index.php?rid=3280711&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20155337%26dopt%3DAbstract Authors: Senju S, Hirata S, Motomura Y, Fukuma D, Matsunaga Y, Fukushima S, Matsuyoshi H, Nishimura Y Dendritic cells (DC) are the most potent antigen-presenting cells. In vivo transfer of antigen-bearing DC has proven efficient in priming T cell responses specific to the antigen. DC-based cellular vaccination is now regarded as a powerful means for immunotherapy, especially for anti-cancer immunotherapy. Clinical trials of therapy with DC pulsed with peptide antigens or genetically modified to present antigens are currently carried out in many institutions. In addition, antigen-specific negative regulation of immune response by DC is considered to be a promising approach for treatments of autoimmune diseases and also for regulation of allo-reactive immune response causing graft reject... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3280711 Sat, 13 Feb 2010 00:00:00 +0100 3280711 http://www.medworm.com/index.php?rid=3280710&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20155338%26dopt%3DAbstract We reported the case of a 75-year-old male who had a primary intestinal multicentric EBV(+) DLBCL and presented with perforation, the first multicentric case in the literature. The monomorphic tumor cells exhibited extensive necrosis and expressed CD20, CD138, and EBNA2 with diffuse positivity for EBV by in situ hybridization. Quantitative real-time PCR revealed a low serum EBV viral load. The patient passed away in 10 days. His poor outcome was probably due to perforation, age over 70, the presence of B symptoms, poor general condition, and high performance score. PMID: 20155338 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3280710 Sat, 13 Feb 2010 00:00:00 +0100 3280710 http://www.medworm.com/index.php?rid=3280709&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20155339%26dopt%3DAbstract Authors: Nakagawa Y, Miura K, Yamazaki T, Ishizuka H, Takei K, Sawada U, Kura Y, Hatta Y, Takeuchi J Although great advancements have been witnessed in treatment results for hematopoietic tumors in recent years, development of secondary malignant tumors induced by anti-cancer drugs still remains a serious issue. We experienced a case of secondary myelodysplastic syndrome (MDS), possibly induced by cyclophosphamide (CY), which was spontaneously resolved by discontinuance of CY. A 24-year-old woman was diagnosed with follicular lymphoma in January 1998: she had developed bulky intra-abdominal lymphadenopathy, with repeated relapse and remission by several chemotherapy treatments. Remission was induced by rituximab, administered at the time of relapse in 2001, followed by administration o... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3280709 Sat, 13 Feb 2010 00:00:00 +0100 3280709 http://www.medworm.com/index.php?rid=3265794&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20146029%26dopt%3DAbstract The objective of this study was to establish guidelines for the safety management of GTX appropriate for the clinical situation in Japan. The Japan Society of Transfusion Medicine and Cell Therapy, Granulocyte Transfusion Task Force issued the first version of guidelines for GTX considering the safety management of both granulocyte donors and patients who receive GTX therapy. The current guidelines cover issues concerning: (1) the appropriateness of medical institutions, (2) management of granulocyte donors, (3) quality assurance of granulocyte concentrates, (4) administration of granulocyte concentrates, (5) evaluation of the effectiveness of GTX therapy, and (6) complications of GTX therapy. The simple 'bag separation method' without apheresis may be recommended for granulocyte collectio... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3265794 Thu, 11 Feb 2010 00:00:00 +0100 3265794 http://www.medworm.com/index.php?rid=3265792&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20146031%26dopt%3DAbstract This report includes a review of the characteristics of 15 reported cases with co-occurrence of CML and Bcr-Abl-negative CMPDs, including ours. Although rare, care needs to be taken since, despite the often similar clinical features of the two diseases, they require completely different treatments. PMID: 20146031 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3265792 Thu, 11 Feb 2010 00:00:00 +0100 3265792 http://www.medworm.com/index.php?rid=3265795&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20146028%26dopt%3DAbstract Authors: Nishiwaki S, Terakura S, Yasuda T, Imahashi N, Sao H, Iida H, Kamiya Y, Niimi K, Morishita Y, Kohno A, Yokozawa T, Ohashi H, Sawa M, Kodera Y, Miyamura K The indication of allogeneic stem cell transplantation (allo-SCT) for Philadelphia chromosome-negative acute lymphocytic leukemia [Ph(-) ALL] from unrelated donors is not established. To assess its potency of unrelated patients in first complete-remission (CR1) transplanted from unrelated donors and the potential prognostic factors affecting the probability of survival, we retrospectively analyzed a total of 41 adult Ph(-) ALL patients in CR1 who underwent unrelated bone marrow transplantation at 6 transplantation centers of the Nagoya Blood and Marrow Transplantation Group between 1993 and 2006. The median age of the 41 pati... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3265795 Wed, 10 Feb 2010 00:00:00 +0100 3265795 http://www.medworm.com/index.php?rid=3265793&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20146030%26dopt%3DAbstract We report a 1-year-old boy with myeloid/NK cell precursor lymphoma/leukemia who presented with a skin nodule. Biopsy of the skin nodule specimen revealed CD45(+), CD56(+), myeloid antigen(+), CD7(-), CD3(-), CD19(-), CD34(-), CD4(-) by flow cytometry and myeloperoxidase (MPO)(+), TdT(+), cytoplasmic CD3(+) by immunohistochemistry. He received acute myeloid leukemia-oriented combination chemotherapy. Although his skin nodule disappeared, regrowth was observed; a biopsy was performed again, showing that the immunophenotype was CD56(+), myeloid antigen(+), HLA-DR(+), MPO(-), CD3(+) and TCRgammadelta(+). Being refractory to chemotherapy, he underwent stem cell transplantation from his father. However, he relapsed again and died from septic shock. Although myeloid/NK cell precursor acute leukem... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3265793 Wed, 10 Feb 2010 00:00:00 +0100 3265793 http://www.medworm.com/index.php?rid=3265791&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20146032%26dopt%3DAbstract Authors: Nicoli P, Guerrasio A PMID: 20146032 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3265791 Wed, 10 Feb 2010 00:00:00 +0100 3265791 http://www.medworm.com/index.php?rid=3265790&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20146033%26dopt%3DAbstract Authors: Law AB, Ryan G, Lade S, Prince HM PMID: 20146033 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3265790 Wed, 10 Feb 2010 00:00:00 +0100 3265790 http://www.medworm.com/index.php?rid=3259390&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20140781%26dopt%3DAbstract Authors: Masroujeh R, Otrock ZK, Yamout B, Jabbour MN, Bazarbachi A A patient was initially diagnosed with right basal ganglia lymphoma causing left hemiparesis. His disease was resistant to intravenous methotrexate, so he received radiation therapy with remarkable regression of the mass. However, 6 months after his initial diagnosis, he developed symmetric weakness of the proximal muscles. Electromyography was consistent with myasthenia gravis and anti-acetylcholine receptor antibodies were elevated. Treatment with pyridostigmine and corticosteroids improved his symptoms. The residual lymphoma was further treated with rituximab and temozolomide with complete resolution. Pyridostigmine and corticosteroids were stopped after 14 months of initiation with good results. Our case is the fir... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3259390 Tue, 09 Feb 2010 00:00:00 +0100 3259390 http://www.medworm.com/index.php?rid=3259389&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20140782%26dopt%3DAbstract Authors: Röth A, Peine S, Dührsen U PMID: 20140782 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3259389 Tue, 09 Feb 2010 00:00:00 +0100 3259389 http://www.medworm.com/index.php?rid=3247423&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20131103%26dopt%3DAbstract Authors: Su D, Zhao H, Xia H Erythropoietin (EPO) controls the production of red blood cells, so it is important to maintain high levels of EPO activity and half-life. Here, we modified glycosylation sites in human erythropoietin (HuEPO) gene, resulting in proteins with addition of 1-4 glycosylation sites. The modified gene was introduced into CHO cells. The expressed EPO analogs were analyzed by SDS-PAGE. Half-life of the analogs was determined by sialic acid content test. In vivo potencies of analogs were evaluated by reticulocyte count and haematocrit level. The metabolic clearance of recombinant human erythropoietin (rHuEPO) and its analogs were determined by EPO immunoradiometrics assay. We have shown that the carbohydrate content in modified EPO molecules is increased. The modifi... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3247423 Fri, 05 Feb 2010 00:00:00 +0100 3247423 http://www.medworm.com/index.php?rid=3247422&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20131104%26dopt%3DAbstract Authors: Kato H, Kohata K, Yamamoto J, Ichikawa S, Watanabe M, Ishizawa K, Ichinohasama R, Harigae H PMID: 20131104 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3247422 Fri, 05 Feb 2010 00:00:00 +0100 3247422 http://www.medworm.com/index.php?rid=3247421&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20135243%26dopt%3DAbstract Authors: Inaba T, Yuki Y, Nishino S, Komatsu S, Ishino H, Tsuji H, Fujita N PMID: 20135243 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3247421 Fri, 05 Feb 2010 00:00:00 +0100 3247421 http://www.medworm.com/index.php?rid=3247425&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20131101%26dopt%3DAbstract Authors: Ricci G, Pigò F, Rossi A, Bersani G, Alvisi V PMID: 20131101 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3247425 Thu, 04 Feb 2010 00:00:00 +0100 3247425 http://www.medworm.com/index.php?rid=3247424&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20131102%26dopt%3DAbstract We report the first case of primary mediastinal large B cell lymphoma (PMBL) with aberrant expression of CD3. PMBL is a subtype of diffuse large B cell lymphoma (DLBCL) and usually presents with bulky mediastinal lesions. Lineage ambiguity/infidelity is uncommon in DLBCL but has been described in sporadic case reports/series. A literature search identifies 13 additional cases of DLBCL expressing CD3, with the majority displaying cytoplasmic expression. Of the 14 total cases, 6 are pyothorax-associated lymphoma, 4 are conventional DLBCL, 2 are plasmablastic lymphoma, one is primary effusion lymphoma and one is PMBL. Two cases show genotypic ambiguity/infidelity with dual clonal IG and TCR gene rearrangements in addition to ambiguous immunophenotypes. Of the 13 cases tested for EBV status, 1... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3247424 Thu, 04 Feb 2010 00:00:00 +0100 3247424 http://www.medworm.com/index.php?rid=3240255&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20127526%26dopt%3DAbstract Authors: Takahashi T, Yamashita K, Hatao K PMID: 20127526 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3240255 Thu, 04 Feb 2010 00:00:00 +0100 3240255 http://www.medworm.com/index.php?rid=3240254&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20127527%26dopt%3DAbstract Authors: Nishiuchi T, Okutani Y, Fujita T, Yoshida K, Ohnishi H, Haba R PMID: 20127527 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3240254 Thu, 04 Feb 2010 00:00:00 +0100 3240254 http://www.medworm.com/index.php?rid=3240253&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20127528%26dopt%3DAbstract Authors: Yabe H, Koike T, Shimizu T, Ishiguro H, Morimoto T, Hyodo H, Akiba T, Kato S, Yabe M PMID: 20127528 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3240253 Thu, 04 Feb 2010 00:00:00 +0100 3240253 http://www.medworm.com/index.php?rid=3221476&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20111912%26dopt%3DAbstract Authors: Suzuki R, Ohtake S, Takeuchi J, Nagai M, Kodera Y, Hamaguchi M, Miyawaki S, Karasuno T, Shimodaira S, Ohno R, Nakamura S, Naoe T Immunological phenotyping of acute leukemia have provided enormous and important information for the classification and lineage determination of leukemia. Forty-nine patients with CD7(+) CD56(+) acute myeloid leukemia (AML) were analyzed. There were 17 patients of M0, which corresponded to myeloid/NK cell precursor acute leukemia, and 32 patients of AML other than M0 (9 each for M1 and M2, one for M3, 3 for M4, 4 for M5 and 6 for M7). Age distribution was similar between these two groups, but CD7(+) CD56(+) M0 showed significant male predominance than CD7(+) CD56(+) M1-M7 (M:F = 15:2 vs. 15:17, P = 0.006). The disease localization and the hematologic... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3221476 Fri, 29 Jan 2010 00:00:00 +0100 3221476 http://www.medworm.com/index.php?rid=3198262&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20091384%26dopt%3DAbstract Authors: Miyazaki T, Kirino Y, Takeno M, Hama M, Ushihama A, Watanabe R, Takase K, Tachibana T, Matsumoto K, Tanaka M, Yamaji S, Ideguchi H, Tomita N, Fujita H, Ohno S, Ueda A, Ishigatsubo Y Heme oxygenase (HO)-1, a heme-degrading enzyme inducible by various stimuli, plays a key role in the regulation of inflammatory response in monocytes/macrophages. The serum HO-1 level is remarkably increased in patients with secondary hemophagocytic syndrome (HPS) or adult-onset Still's disease. We measured serum HO-1 levels in patients with a variety of hematological diseases, including secondary HPS, by means of ELISA. Serum HO-1 levels were significantly higher in 22 patients with HPS (134.7 +/- 116.2 ng/mL, P < 0.0001) at diagnosis than in 80 patients with other hematological diseases. The m... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3198262 Fri, 22 Jan 2010 00:00:00 +0100 3198262 http://www.medworm.com/index.php?rid=3198261&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20091385%26dopt%3DAbstract Authors: Yoshida H, Hashii Y, Okuda T, Kusuki S, Sato E, Inoue A, Kawakami C, Yabe M, Ohta H, Ozono K PMID: 20091385 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3198261 Fri, 22 Jan 2010 00:00:00 +0100 3198261 http://www.medworm.com/index.php?rid=3198264&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20087795%26dopt%3DAbstract Authors: Kondo T, Yasumoto A, Arita K, Sugita JI, Shigematsu A, Okada K, Takahata M, Onozawa M, Kahata K, Takeda Y, Obara M, Yamamoto S, Endo T, Nishio M, Sato N, Tanaka J, Hashino S, Koike T, Asaka M, Imamura M Acute myelogenous leukemia (AML) with favorable cytogenetics responds well to chemotherapy. If the leukemia relapses, allogenic hematopoietic stem transplantation (allo-HSCT) is considered as a treatment option. Since the efficacy of reduced-intensity stem cell transplantation (RIST) for AML with favorable cytogenetics has not been established, we retrospectively analyzed the outcomes of allo-HSCT in AML patients according to cytogenetic risks. The outcome of allo-HSCT for AML patients with favorable cytogenetics seemed to be superior to that for AML patients with intermediate ... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3198264 Wed, 20 Jan 2010 00:00:00 +0100 3198264 http://www.medworm.com/index.php?rid=3198263&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20087796%26dopt%3DAbstract Authors: Yanai S, Adachi Y, Shi M, Shigematsu A, Shima C, Imai Y, Kwon AH, Ikehara S There have been reports that bone marrow cells (BMCs) can differentiate into various cells and tissues and that BMCs improve the function of the injured organs or reduce the organ damage, thereby rescuing the individuals from death. However, these reports also noted that injuries were induced in the organs. Therefore, it is not clear whether BMCs can differentiate into parenchymal cells in organs in normal life or whether BMCs can supply organ-specific stem cells. In this paper, we examine whether adult BMCs could contribute to the development of various organs in normal development after birth and in normal life. BMCs from adult eGFP mice (8 weeks old) were injected into the liver of newborn C57BL/6 m... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3198263 Wed, 20 Jan 2010 00:00:00 +0100 3198263 http://www.medworm.com/index.php?rid=3190086&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20084476%26dopt%3DAbstract This study aims to investigate the role of stromal cell-derived factor 1alpha (SDF-1alpha) and its receptor CXCR4 in cellular infiltration of the lung in differentiation syndrome (DS). The acute promyelocytic leukemia (APL) NB4 cells and freshly prepared APL cells from the patients were differentiated by all-trans retinoic acid (ATRA). The expression of SDF-1alpha in human lung tissues was examined by RT-PCR and Western blot analysis. The cells were subjected to adhesion, migration or invasion assays, and co-cultured with human lung tissues in a microgravity rotary cell culture system to examine cellular infiltration in situ. ATRA-differentiated cells expressed high levels of CXCR4, and adhered more strongly to matrigel. Their ability to migrate and invade was enhanced by SDF-1alpha and lu... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3190086 Tue, 19 Jan 2010 00:00:00 +0100 3190086 http://www.medworm.com/index.php?rid=3190088&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20082159%26dopt%3DAbstract Authors: Kagoya Y, Hangaishi A, Takahashi T, Imai Y, Kurokawa M PMID: 20082159 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3190088 Sat, 16 Jan 2010 00:00:00 +0100 3190088 http://www.medworm.com/index.php?rid=3190087&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20082160%26dopt%3DAbstract Authors: Kihara H, Ohno N, Karakawa S, Mizoguchi Y, Fukuhara R, Hayashidani M, Nomura S, Nakamura K, Kobayashi M Early thrombocytopenia is a common hematological abnormality in sick neonates. Here, we examined the relationship between early thrombocytopenia in neonates and parameters associated with thrombopoiesis to identify predictive factors at birth. Two hundred and forty-four neonates admitted to the neonatal intensive care unit were divided into thrombocytopenic (n = 55, 23%) and non-thrombocytopenic (n = 189, 77%) groups based on platelet counts, which were monitored within 72 h of birth. Immature platelet fraction (IPF) and platelet count at birth were determined simultaneously soon after phlebotomy with an automated hematology analyzer. Megakaryocytes and their precursors posi... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3190087 Sat, 16 Jan 2010 00:00:00 +0100 3190087 http://www.medworm.com/index.php?rid=3167614&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20066573%26dopt%3DAbstract In this study, we produced two monoclonal antibodies (mAbs) that specifically react to the delta-globin chain of HbA(2). A sandwich type ELISA was developed employing the produced anti-HbA(2) mAbs. HbA(2) levels quantified by the developed sandwich ELISA were highly correlated with those obtained from the standard HPLC method (r = 0.934, p < 0.001). HbA(2) levels determined by the ELISA were 4.4 +/- 1.9% in beta-thalassemia heterozygotes compared to 1.4 +/- 0.8, 1.9 +/- 0.8, 1.5 +/- 0.8 and 1.5 +/- 0.6% in normal subjects, HbE heterozygotes, suspected alpha-thalassemia heterozygotes and HbE homozygotes, respectively. Using a cut-off value of 2.5%, beta-thalassemia heterozygotes could be separated from non-beta-thalassemia heterozygotes with the same accuracy as obtained using the standa... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3167614 Wed, 13 Jan 2010 00:00:00 +0100 3167614 http://www.medworm.com/index.php?rid=3167612&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20066574%26dopt%3DAbstract Authors: Seki R, Ohshima K, Nagafuji K, Fujisaki T, Uike N, Kawano F, Gondo H, Makino S, Eto T, Moriuchi Y, Taguchi F, Kamimura T, Tsuda H, Ogawa R, Shimoda K, Yamashita K, Suzuki K, Suzushima H, Tsukazaki K, Higuchi M, Utsunomiya A, Iwahashi M, Imamura Y, Tamura K, Suzumiya J, Yoshida M, Abe Y, Matsumoto T, Okamura T We performed a retrospective analysis of patients with diffuse large B cell lymphoma treated with rituximab plus CHOP (cyclophosphamide, adriamycin, vincristine and prednisone) as a first-line therapy at 22 hospitals of the Kyushu Lymphoma Study Group. During the period 1996-2005, 1,057 patients (aged 22-90 years) were analyzed. Of these, 678 were treated with CHOP, and 379 were treated with rituximab plus CHOP (R-CHOP). The complete response rate was 59.9% in the CHOP gr... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3167612 Wed, 13 Jan 2010 00:00:00 +0100 3167612 http://www.medworm.com/index.php?rid=3167621&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20063131%26dopt%3DAbstract We describe herein a case of MCL diagnosed in an initially asymptomatic 66-year-old woman who developed transfusion-dependent AIHA 6 months later coincident with lymphoma progression. The AIHA failed to respond satisfactorily to conventional treatment (high-dose oral prednisolone) but rapidly resolved following commencement of non-rituximab-containing combination chemotherapy in parallel with complete remission of the lymphoma. This is the first of such cases to be described in the literature and confirms that the immune environment of MCL can predispose to AIHA in the same way as in other lymphoma subtypes. Despite this being an infrequent occurrence, clinicians should be aware that AIHA is a potential complication of MCL and may be more successfully controlled by treating the underlying ... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3167621 Sat, 09 Jan 2010 00:00:00 +0100 3167621 http://www.medworm.com/index.php?rid=3167620&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20063132%26dopt%3DAbstract Authors: Hangaishi A, Takahashi T, Masuda A, Okada S, Kandabashi K, Kurokawa M PMID: 20063132 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3167620 Sat, 09 Jan 2010 00:00:00 +0100 3167620 http://www.medworm.com/index.php?rid=3167619&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20063133%26dopt%3DAbstract Authors: Sakamaki H, Miyawaki S, Ohtake S, Emi N, Yagasaki F, Mitani K, Matsuda S, Kishimoto Y, Miyazaki Y, Asou N, Takahashi M, Ogawa Y, Honda S, Ohno R We prospectively compared allogeneic hematopoietic stem cell transplantation (allo-HSCT) with chemotherapy as a post-remission therapy in a multicenter trial (JALSG AML97) of adult patients with intermediate or poor risk acute myeloid leukemia (AML). Of 503 patients aged 15-50 years old registered between December 1997 and July 2001, 392 achieved complete remission (CR). CR patients classified in the intermediate or poor risk group using a new scoring system were tissue typed. Seventy-three with and 92 without an HLA-identical sibling were assigned to the donor and no-donor groups. Of 73 patients in the donor group, 38 (52%) received ... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3167619 Sat, 09 Jan 2010 00:00:00 +0100 3167619 http://www.medworm.com/index.php?rid=3156869&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20058208%26dopt%3DAbstract Authors: Kiss JE Thrombotic thrombocytopenic purpura is a life-threatening multisystem disorder that represents both a diagnostic and a management challenge to clinicians. Early recognition of the condition coupled with rapid institution of plasma exchange has led to a dramatic improvement in prognosis. Studies performed over the past decade have elucidated the predominant pathophysiology, stemming from a deficiency of ADAMTS13, that accounts for the widespread microvascular deposition of platelet-von Willebrand factor in many sites, including the brain, kidney, and mesenteric vessels. However, in light of the mortality rate of 10-20%, much work remains to be done to translate advances in our understanding of pathophysiology into clinical practice. Improvements in medical management us... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3156869 Sat, 09 Jan 2010 00:00:00 +0100 3156869 http://www.medworm.com/index.php?rid=3156868&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20058209%26dopt%3DAbstract Authors: Tsai HM Thrombotic thrombocytopenic purpura (TTP) is a disorder with characteristic von Willebrand factor (VWF)-rich microthrombi affecting the arterioles and capillaries of multiple organs. The disorder frequently leads to early death unless the patients are treated with plasma exchange or infusion. Studies in the last decade have provided ample evidence to support that TTP is caused by deficiency of a plasma metalloprotease, ADAMTS13. When exposed to high shear stress in the microcirculation, VWF and platelets are prone to form aggregates. This propensity of VWF and platelet to form microvascular thrombosis is mitigated by ADAMTS13, which cleaves VWF before it is activated by shear stress to cause platelet aggregation in the circulation. Deficiency of ADAMTS13, due to autoim... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3156868 Sat, 09 Jan 2010 00:00:00 +0100 3156868 http://www.medworm.com/index.php?rid=3156872&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20054668%26dopt%3DAbstract Authors: Uemura M, Fujimura Y, Ko S, Matsumoto M, Nakajima Y, Fukui H The liver is a major source of clotting and fibrinolytic proteins, and plays a central role in thrombo-regulation. Patients with advanced liver diseases tend to bleed because of reduced plasma levels of several clotting factors and thrombocytopenia, but they do also exhibit thrombotic complications. ADAMTS13 is a metalloproteinase, produced exclusively in hepatic stellate cells, and specifically cleaves highly multimeric von Willebrand factor (VWF). VWF plays a pivotal role in hemostasis and thrombosis, and its function is dependent on its multimeric state. Deficiency of ADAMTS13 results in accumulation of unusually large VWF multimers (UL-VWFM) in plasma, in turn induces platelet clumping or thrombi under high shear... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3156872 Thu, 07 Jan 2010 00:00:00 +0100 3156872 http://www.medworm.com/index.php?rid=3156871&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20054669%26dopt%3DAbstract Authors: Ohtake S, Miyawaki S, Kiyoi H, Miyazaki Y, Okumura H, Matsuda S, Nagai T, Kishimoto Y, Okada M, Takahashi M, Handa H, Takeuchi J, Kageyama S, Asou N, Yagasaki F, Maeda Y, Ohnishi K, Naoe T, Ohno R A multicenter, prospective, randomized study was conducted to compare a response-oriented individualized remission induction therapy with a standard fixed-schedule induction therapy, using idarubicin (IDR) and cytarabine (Ara-C), in adult patients with acute myeloid leukemia (AML). Newly diagnosed patients with AML of age less than 65 were randomly assigned to receive either of the two schedules. Both groups received IDR (12 mg/m(2)) for 3 days and Ara-C (100 mg/m(2)) for 7 days. In the individualized group, if the bone marrow on day 8 did not become hypocellular with less than 15% b... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3156871 Thu, 07 Jan 2010 00:00:00 +0100 3156871 http://www.medworm.com/index.php?rid=3156870&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20054670%26dopt%3DAbstract Authors: Mattar M A 50-year-old woman presented with CML-CP and was initially treated with branded imatinib (Glivec((R))) 400 mg/day. She rapidly achieved a complete hematologic response (CHR), at which point she switched therapy to a copy version of imatinib (Imatib). She received 400 mg/day of Imatib for 3 months, during which time her platelet count decreased from 250 x 10(9) to 105 x 10(9)/L and her hemoglobin count fell from 12.8 to 11 g/dL. The patient's total leukocyte count rose rapidly from 4 x 10(9) to 70 x 10(9)/L, and the CHR was lost. At this point, therapy was switched back to Glivec at 400 mg/day, and the CHR was rapidly regained. Furthermore, the patient achieved a major cytogenetic response by 6 months after reintroduction of Glivec. This case report suggests a differe... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3156870 Thu, 07 Jan 2010 00:00:00 +0100 3156870 http://www.medworm.com/index.php?rid=3149739&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20049564%26dopt%3DAbstract The objectives of this study are to clarify (1) the difference in demographic and clinical variables at initial presentation between acute and chronic idiopathic thrombocytopenic purpura (ITP), and (2) the prognostic factors of patients with chronic ITP. We conducted a retrospective analysis of 247 children with newly diagnosed ITP between April 1991 and March 2006 who visited one of the 12 hospitals belonging to the Kyoto University Pediatric Hematologic Study Group. 180 and 67 cases were classified as the acute type and as the chronic type, respectively. Older age, higher initial platelet count, positive medical history or concomitant medical diagnosis, the absence of preceding infection or vaccination, and the absence of an increase in immunoglobulin were risk factors for the chronicity... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3149739 Tue, 05 Jan 2010 00:00:00 +0100 3149739 http://www.medworm.com/index.php?rid=3149738&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20049565%26dopt%3DAbstract Authors: Iqbal MS, Otsuyama KI, Shamsasenjan K, Asaoku H, Kawano MM CD56 is frequently detected on primary myeloma cells from more than 80% patients with overt myeloma. In order to clarify the possible mechanisms of CD56 expression in human myeloma, we underwent screening for potential targets by microarray analysis, where the CD56(+) myeloma cell lines showed markedly increased expressions of transcription factors involved in the neuronal cell lineage compared to the CD56(-) myeloma cell lines. Here, we show that among the SOX family of transcription factors, SOX4 was highly up-regulated and SOX1 was down-regulated in the CD56(+) myeloma cell lines as well as in primary myeloma cases as confirmed by the RT-PCR. ChIP analysis of the CD56 promoter region showed specific bindings of SOX4... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3149738 Tue, 05 Jan 2010 00:00:00 +0100 3149738 http://www.medworm.com/index.php?rid=3143313&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20047094%26dopt%3DAbstract Authors: Banno F, Chauhan AK, Miyata T Recently, two independent groups have established ADAMTS13-deficient mice using gene-targeting techniques. In humans, genetic or acquired deficiency in ADAMTS13 leads to a potentially fatal syndrome, thrombotic thrombocytopenic purpura (TTP). Surprisingly, ADAMTS13-deficient mice are viable with no apparent signs of TTP. However, these mouse models indicate that ADAMTS13 down-regulates platelet adhesion and aggregation in vivo, and ADAMTS13 deficiency can provide enhanced thrombus formation at the site of vascular lesions. In addition, ADAMTS13 by cleaving hyperactive ultra-large von Willebrand factor multimers not only down-regulates thrombosis but also inflammation. ADAMTS13-congenic mice that carry a truncated form of ADAMTS13 lacking the C-ter... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3143313 Tue, 05 Jan 2010 00:00:00 +0100 3143313 http://www.medworm.com/index.php?rid=3143312&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20047095%26dopt%3DAbstract In conclusion, it is necessary to introduce the first line therapy excluding the chemotherapy that can prolong survival in patients with high-risk MDS and MDS-AML. PMID: 20047095 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3143312 Tue, 05 Jan 2010 00:00:00 +0100 3143312 http://www.medworm.com/index.php?rid=3143311&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20047096%26dopt%3DAbstract Authors: Hangaishi A, Kurokawa M B lymphocyte-induced maturation protein (Blimp-1) is a transcriptional factor, which controls the terminal differentiation of mature B cells to plasma cells. Blimp-1 is also called positive regulatory domain I-binding factor-1 (PRDI-BF1) or PR (PRDI-BF1-RIZ) domain zinc finger protein 1 (PRDM1). Furthermore, Blimp-1 is located in chromosome 6q21-22.1, a region frequently deleted in several tumors including lymphoid malignancies and has been supposed to be a candidate of tumor suppressor gene. Recently, mutational inactivation of Blimp-1 has been identified in a subset of diffuse large B-cell lymphomas of the activated B-cell type. In addition, an important role for Blimp-1 in maintaining the homeostasis of effector T cells is emerging and high expressio... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3143311 Tue, 05 Jan 2010 00:00:00 +0100 3143311 http://www.medworm.com/index.php?rid=3143310&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20047097%26dopt%3DAbstract We report a 60-year-old man who initially presented with phenotype of polycythemia vera (PV), which evolved into chronic myeloid leukemia and back to PV once treatment with imatinib was commenced. JAK2 V617F mutation and BCR-ABL fusion transcripts were detected in the initial sample. However, JAK2 V617F alleles diminished when BCR-ABL mRNA burden increased and reappeared once the patient was commenced on imatinib. The dynamic interaction between JAK2 V617F and BCR-ABL implies that two independent clones exist with the JAK2 V617F clone only achieving clonal dominance when BCR-ABL positive clones are suppressed by imatinib. PMID: 20047097 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3143310 Tue, 05 Jan 2010 00:00:00 +0100 3143310 http://www.medworm.com/index.php?rid=3143309&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20047098%26dopt%3DAbstract Authors: Motohashi K, Hagihara M, Ito S, Tachibana T, Takasaki H, Tanaka M, Maruta A, Ishigatsubo Y, Kanamori H PMID: 20047098 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3143309 Tue, 05 Jan 2010 00:00:00 +0100 3143309 http://www.medworm.com/index.php?rid=3143308&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20047099%26dopt%3DAbstract We report a case of imatinib- and nilotinib-resistant Ph-positive chronic myeloid leukemia (CML) in blast crisis in which successful pretreatment with dasatinib with cord blood transplantation resulted in molecular remission. Before dasatinib therapy, the patient was found to have a F359V BCR-ABL mutation. He was treated with dasatinib for just 16, 19 days before allogeneic stem cell transplantation. This successful case indicates that reduction of tumor burden by second-generation tyrosine kinase inhibitors, in combination with stem cell transplantation, might be effective to treat CML, even in the advanced phase. PMID: 20047099 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3143308 Tue, 05 Jan 2010 00:00:00 +0100 3143308 http://www.medworm.com/index.php?rid=3127027&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20037749%26dopt%3DAbstract In this study, we reported the outcomes of hematopoietic stem cell transplantation (HSCT) as a treatment modality for pediatric patients admitted over the past 20 years in a single institute. From January 1989 to January 2007, 26 patients with a median age of 8 years underwent 14 matched sibling donor (MSD) and 12 alternative donor (AD) transplantations. Two patients received second transplantation successfully after primary graft failure and late graft rejection. Two patients who received transplantation from matched unrelated donors (MUD) died of sepsis, and one of them also had a graft failure at death. The overall 5-year survival rate was 92.1%: 83.3% for AD transplantation and 100% for MSD transplantation. Grade II acute graft versus host disease (GVHD) developed in 3 patients, and ex... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3127027 Sat, 26 Dec 2009 00:00:00 +0100 3127027 http://www.medworm.com/index.php?rid=3127026&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20037750%26dopt%3DAbstract Authors: Braggio E, Maiolino A, Gouveia ME, Magalhães R, Souto Filho JT, Garnica M, Nucci M, Renault IZ Aberrant methylation in promoter-associated CpG islands has been recognized as a major mechanism for tumor suppressor gene silencing in several malignancies. We determined the methylation status of nine tumor suppressor genes in 68 newly diagnosed MM patients by methylation-specific PCR. The frequency of promoter hypermethylation for individual genes was: CDH1, 50%; p16 ( INK4a ), 42.8%; p15 ( INK4b ), 16.2%; SHP1, 14.7%; ER and BNIP3, 13.2%; RARbeta, 11.8%; DAPK 5.9%; and MGMT 0%. Overall, 79% of patients presented at least one hypermethylated gene. By univariate analysis, hypermethylation of DAPK (P < 0.001) and RARbeta (P = 0.01) genes were identified as adverse prognostic... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3127026 Sat, 26 Dec 2009 00:00:00 +0100 3127026 http://www.medworm.com/index.php?rid=3123626&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20035486%26dopt%3DAbstract Authors: Tanaka M, Fukushima N, Itamura H, Urata C, Yokoo M, Ide M, Hisatomi T, Tomimasu R, Sueoka E, Kimura S A 67-year-old Japanese woman who presented with erythema on the abdomen and pancytopenia was found to have acute promyelocytic leukemia (APL). A skin biopsy revealed invasion of APL cells. She was started on induction treatment with all-trans retinoic acid (ATRA) at 45 mg/m(2). On day 4, the leukemic cell number had increased to over 1.0 x 10(9)/L. Consequently, chemotherapy with idarubicin and cytarabine was initiated. On day 10, dryness of the lips appeared. The lower lip swelled and developed painful black eschars. A high fever was also present. Despite discontinuing ATRA on day 20 and administering antibiotics, an anti-fungal agent and valaciclovir, these signs did not imp... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3123626 Fri, 25 Dec 2009 00:00:00 +0100 3123626 http://www.medworm.com/index.php?rid=3121003&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20033799%26dopt%3DAbstract Authors: Kobayashi Y, Hatta Y, Ishizuka H, Hirabayashi Y, Tanaka T, Takei K, Takeuchi J PMID: 20033799 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3121003 Fri, 25 Dec 2009 00:00:00 +0100 3121003 http://www.medworm.com/index.php?rid=3121002&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20033800%26dopt%3DAbstract We report here on a case of an HIV-1-seropositive patient with acute myelogenous leukemia who underwent a successful allogeneic unrelated bone marrow transplantation following HAART. A 40-year-old Japanese HIV-seropositive man underwent allogeneic unrelated bone marrow transplantation using a myeloablative pretransplant-conditioning regimen. Neutrophil engraftment occurred on day +18, and donor chimerism was achieved on day +27. During pre- and post- transplantation, the HAART was not interrupted. Over 1 year after transplantation, the patient is alive and in continuous complete remission with undetectable levels of HIV-1 RNA. HAART can lead to a successful hematopoietic stem cell transplantation without severe opportunistic infections. PMID: 20033800 [PubMed - as supplied by publisher... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3121002 Fri, 25 Dec 2009 00:00:00 +0100 3121002 http://www.medworm.com/index.php?rid=3121004&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20033628%26dopt%3DAbstract Authors: Zhai L, Guo C, Cao Y, Xiao J, Fu X, Huang J, Huang H, Guan Z, Lin T Pirarubicin is an analog of doxorubicin. Few studies have compared the long-term outcomes of patients receiving pirarubicin-based THP-COP and doxorubicin-based CHOP in the treatment of non-Hodgkin's lymphoma (NHL). We retrospectively compared the efficacy and safety of these two regimens in 459 previously untreated aggressive NHL patients admitted to Sun Yat-Sen University Cancer Center from 1987 to 2003. For initial treatment, 205 patients received the THP-COP regimen, and 254 patients received the CHOP regimen. The patients' characteristics were well balanced. The groups did not differ in the complete remission rate (THP-COP, 57.1% vs. CHOP, 57.0%; P = 0.998) or response rate (THP-COP, 82.9% vs. CHOP, 81.5%;... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3121004 Wed, 23 Dec 2009 00:00:00 +0100 3121004 http://www.medworm.com/index.php?rid=3106712&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20020229%26dopt%3DAbstract Authors: Rosser A, Swallow G, Swann RA, Chapman C PMID: 20020229 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3106712 Fri, 18 Dec 2009 00:00:00 +0100 3106712 http://www.medworm.com/index.php?rid=3106711&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20020230%26dopt%3DAbstract We report an unusual dermatological reaction to bortezomib in a 61-year-old man with AL amyloidosis. Systemic AL amyloidosis is a rare complication of monoclonal gammopathy or myeloma in which abnormally unstable free light chains cause fibrillary deposits in organs leading to multisystem disease. The treatment of AL amyloidosis is directed at the underlying plasma cell dyscrasia and most regimes have been adapted from myeloma, but drug toxicity is more common in AL amyloidosis because of the more extensive nature of the disease. We report a patient who developed asymptomatic purple discolouration of the veins of his left arm several days after receiving the infusion in his left hand, although the infusion itself had been uncomplicated with no extravasation. The discolouration resolved com... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3106711 Fri, 18 Dec 2009 00:00:00 +0100 3106711 http://www.medworm.com/index.php?rid=3101411&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20013322%26dopt%3DAbstract We describe Influenza A/pandemic 2009/H1N1 in two allogeneic hematopoietic cell transplantation recipients. The main presentation in both cases consisted of flu-like symptoms manifesting as, fever, arthralgias and myalgias. The virus was isolated in one case from a throat swab and in another case following a bronchoalveolar lavage. Both patients received oseltamivir at a dose of 75 mg orally twice day. The dose of oseltamivir was increased to 150 mg twice per day due to the lack of improvement or progression of symptoms. In one case, clinical symptoms resolved without sequelae. In the second case, pulmonary symptomatology continued to deteriorate, despite aggressive polymicrobial treatment, requiring mechanical ventilation and ultimately the patient died from respiratory failure. These cas... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3101411 Wed, 16 Dec 2009 00:00:00 +0100 3101411 http://www.medworm.com/index.php?rid=3101410&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20013323%26dopt%3DAbstract Authors: Ikezoe T, Yang J, Nishioka C, Yokoyama A We previously showed that AZD1152-HQPA, the inhibitor of Aurora B kinase potently induced growth arrest and apoptosis of various types of human leukemia cells including MV4-11 acute myelogenous leukemia (AML) cells, although the molecular mechanisms by which this class of kinase inhibitors induces apoptosis remain to be fully elucidated. We have recently established the MV4-11 subline, designated as MV4-11 TP53 R248W, which possesses transcriptionally inactive R248W mutation in the TP53 gene. MV4-11 TP53 R248W cells were relatively resistant to AZD1152-HQPA-mediated growth arrest, as measured by MTT and clonogenic assays. AZD1152-HQPA (10-100 nM, 48 h) strikingly induced apoptosis of MV4-11 cells, as assessed by Annexin V binding, loss ... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3101410 Wed, 16 Dec 2009 00:00:00 +0100 3101410 http://www.medworm.com/index.php?rid=3101409&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20013324%26dopt%3DAbstract Authors: Meyer T, Ruppert V, Görg C, Neubauer A The somatic V617F mutation in the Janus kinase (JAK) 2 gene, which causes a valine to phenylalanine substitution at position 617, has recently been found in the majority of patients with polycythemia vera and in many cases with essential thrombocythemia or idiopathic myelofibrosis. Here, we report on a 76-year-old female patient presenting with JAK2V617F-positive polycythemia vera and a pelvic mass with extramedullary hematopoiesis. Immunohistochemistry demonstrated tyrosine phosphorylation of JAK2 kinase as well as STAT1 and STAT5 transcription factors. However, only a minority of the total STAT1 pool was tyrosine-phosphorylated and, in contrast to its unphosphorylated counterpart, phospho-STAT1 clearly showed nuclear accumulation. ... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3101409 Wed, 16 Dec 2009 00:00:00 +0100 3101409 http://www.medworm.com/index.php?rid=3101414&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20012511%26dopt%3DAbstract Authors: Kameoka Y, Takahashi N, Tagawa H, Fujishima N, Yoshioka T, Saito H, Hirokawa M, Ichinohasama R, Sawada K PMID: 20012511 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3101414 Sat, 12 Dec 2009 00:00:00 +0100 3101414 http://www.medworm.com/index.php?rid=3101413&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20012512%26dopt%3DAbstract Authors: Guo YM, Hirokawa M, Takahashi N, Fujishima M, Fujishima N, Komatsuda A, Tagawa H, Ohyagi H, Michishita Y, Ubukawa K, Hebiguchi M, Xiao W, Sawada K We have developed a method that cells exhibiting typical dendritic cell (DC) characteristics are generated from human CD34(+) cells and phagocytose cogenerating erythroid progenitor cells in the presence of tumor necrosis factor-alpha (TNF-alpha), interleukin-3, stem cell factor and erythropoietin. Using this system, we titrated the effects of TNF antagonists, etanercept and infliximab, on TNF-alpha activity. We found that 1 mug/ml etanercept dramatically inhibited the generation of CD11c(+) cells accompanying with a complete recovery of the generation of erythroid progenitors. Infliximab at 200 mug/ml exhibited a similar effect to ... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3101413 Sat, 12 Dec 2009 00:00:00 +0100 3101413 http://www.medworm.com/index.php?rid=3101412&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20012513%26dopt%3DAbstract Authors: Chen YF, Li YC, Chen LM, Tu CC, Chang CC, Kuo SY, Lin SH, Chuang SS Primary cutaneous large B cell lymphoma, leg type (PCLBCL-leg) has recently been identified and recognized as a specific entity. Patients with PCLBCL-leg have a higher relapse rate and a poorer prognosis than the other types of primary cutaneous B cell lymphomas, and disease relapse is confined to the skin in the majority of cases with rare exclusive extracutaneous progression. The late occurrence of lymphoma in patients with a prior history of lymphoma may represent a relapse/progression or a distinct tumor unrelated to the original one. The distinction is of important clinical and therapeutic implications. Here, we report the case of a 90-year-old lady with a history of PCLBCL-leg in complete remission after... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3101412 Sat, 12 Dec 2009 00:00:00 +0100 3101412 http://www.medworm.com/index.php?rid=3076389&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19998064%26dopt%3DAbstract Authors: Matsushita H, Masukawa A, Arakawa S, Ogawa Y, Asai S, Yabe M, Ando K, Miyachi H We herein report the findings of a 47-year-old Japanese female with chronic myeloid leukemia (CML) with a cryptic BCR-ABL1 transcript on chromosome 9 and a derivative chromosome 22 unrelated to BCR-ABL1. Although she achieved and continued to demonstrate a major molecular response to imatinib treatment following interferon-alpha, there was persistence of a derivative chromosome 22. A detailed chromosome/molecular studies, including serial karyotyping analysis, finally resulted in the karyotyping at the disease onset to be 47,XX,+del(22)(q11.2), with two genetic evens, namely a cryptic BCR-ABL1 transcript on chromosome 9 and derivative chromosome 22 unrelated to BCR-ABL1. This CML case with these tw... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3076389 Thu, 10 Dec 2009 00:00:00 +0100 3076389 http://www.medworm.com/index.php?rid=3076388&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19998065%26dopt%3DAbstract We examined the use of IL-2 and growth factors for mobilization, ex vivo activation of peripheral blood stem cell (PBSC) and maintenance therapy after HDC/AHST in metastatic breast cancer. Eligible patients with metastatic breast cancer for HDC/AHST were assigned to 1 of 3 protocols for PBSC mobilization: G-CSF (group 1); IL-2 + G-CSF (group 2); or IL-2 + G-CSF + GM-CSF (group 3). HDC with cyclophosphamide, carmustine and thiotepa was given from day -7 to -5. PBSCs were treated ex vivo with IL-2 for 24 h and reinfused on day 0. Maintenance therapy included low-dose IL-2, followed by 2 courses of intermediate-dose IL-2. GM-CSF was given from day 1 until neutrophil recovery. Thirty-four patients (10 in group 1, 14 in group 2, and 10 in group 3) were included. Comparable numbers of CD34(+) ce... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3076388 Wed, 09 Dec 2009 00:00:00 +0100 3076388 http://www.medworm.com/index.php?rid=3060054&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19957058%26dopt%3DAbstract Authors: Priola AM, Picciotto G, Priola SM PMID: 19957058 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3060054 Fri, 04 Dec 2009 00:00:00 +0100 3060054 http://www.medworm.com/index.php?rid=3052923&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19949902%26dopt%3DAbstract We report the case of a 52-year-old woman with progressive advanced nasal NK/T cell lymphoma, with local invasiveness and bone marrow involvement, who was successfully treated with unrelated cord blood transplantation (UCBT). The patient was initially refractory to conventional chemotherapy. She was therefore treated with local irradiation, which induced a partial response. The patient then underwent UCBT using a conditioning regimen consisting of cyclophosphamide and total body irradiation. Acute graft-versus-host disease involving the skin was observed, but it was well controlled without systemic administration of corticosteroids. The patient remained in complete remission for 18 months after UCBT. Although the observation period has been relatively short and longer follow-up is needed, ... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3052923 Wed, 02 Dec 2009 00:00:00 +0100 3052923 http://www.medworm.com/index.php?rid=3037311&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19943126%26dopt%3DAbstract Authors: Misawa Y, Baba A, Ito S, Tanaka M, Shiohara M Bactericidal activities of neutrophils occur by two distinctive mechanisms that are oxygen-dependent and -independent. Human cathelicidin antimicrobial peptide 18 (hCAP18), also known as LL-37/FALL-39, is a neutrophil-specific granule protein. We compared the content of hCAP18 and neutrophil gelatinase-associated lipocalin (NGAL), another neutrophil-specific granule protein, in neutrophils of both neonates and adults by flow cytometry. The percentage as well as fluorescence intensity ratio of hCAP18 and NGAL expression in neonate neutrophils were significantly lower than in adults. Expression of hCAP18 in monocytes, however, was not significantly different between neonates and adults. Both hCAP18 and NGAL expression increased in an... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3037311 Sat, 28 Nov 2009 00:00:00 +0100 3037311 http://www.medworm.com/index.php?rid=3027962&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19937482%26dopt%3DAbstract Authors: Sasaki Y, Matsuoka Y, Hase M, Toyohara T, Murakami M, Takahashi M, Nakatsuka R, Uemura Y, Sonoda Y Stromal cell-derived factor 1 (SDF-1) and its receptor CXCR4 are the key regulatory molecules of hematopoietic stem cell (HSC) migration and engraftment to the bone marrow (BM) microenvironment. However, the significance of the ligand-receptor complex on HSC in steady-state BM is not clear. There is currently a lack of information as to how CXCR4 is expressed on HSCs. We herein demonstrate that c-kit(+)Sca-1(+)Lineage(-) (KSL) cells freshly isolated from BM expressed very low to undetectable levels of CXCR4. Two hours of incubation at 37 degrees C quickly up-modulated the receptor expression on KSL cells. Protein synthesis was not required for this early stage up-regulation, thus... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3027962 Thu, 26 Nov 2009 00:00:00 +0100 3027962 http://www.medworm.com/index.php?rid=3027963&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19937165%26dopt%3DAbstract We present two cases of follicular lymphoma with transformation to Burkitt-like lymphoma. In both cases dual translocations involving both the bcl-2 and c-myc loci were present. Each patient underwent intensive induction immunochemotherapy followed by autologous stem cell transplantation and radiation therapy. The first patient received post-transplant mediastinal radiation and developed recurrence in multiple areas outside of the radiation field. The second patient received total body irradiation as part of the conditioning regimen, and is without recurrence 18 months after transplant, and 24 months after diagnosis of the dual translocated lymphoma. We review dual translocation B cell lymphoma in the setting of transformation from follicular lymphoma, and suggest a potential role for tota... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3027963 Wed, 25 Nov 2009 00:00:00 +0100 3027963 http://www.medworm.com/index.php?rid=3027961&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19937483%26dopt%3DAbstract We examined whether TGT was useful for evaluating hemophilia A patients with very low levels of FVIII:C. TGTs in 40 hemophilia A plasmas with FVIII:C < 0.2-17 IU/dl (measured by clot waveform analysis using MDA-II) were performed using TF and/or ellagic acid (ELG). The lagtime in ELG-TGT at very low levels of FVIII:C was shortened dose-dependently, whilst this parameter in TF-TGT was not significantly affected. Other parameters (endogenous thrombin potential, peak thrombin, time to peak) correlated with FVIII:C levels to some extent in both assays (r = 0.4-0.7). Using a TF/ELG mixture in TGT, however, the correlation coefficients increased to ~0.85. TGT parameters correlated well with levels of FVIII:C > 0.2 IU/dl, although the lagtime was not especially informative. We conclude that... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3027961 Wed, 25 Nov 2009 00:00:00 +0100 3027961 http://www.medworm.com/index.php?rid=3027960&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19937484%26dopt%3DAbstract Authors: Nakazato T, Suzuki K, Mihara A, Sanada Y, Aisa Y, Kakimoto T PMID: 19937484 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3027960 Wed, 25 Nov 2009 00:00:00 +0100 3027960 http://www.medworm.com/index.php?rid=3027959&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19937485%26dopt%3DAbstract Authors: Yokus O, Albayrak M, Balcik OS, Ceran F, Dagdas S, Yilmaz M, Ozet G The increased risk for thrombosis is known as hypercoagulability or thrombophilia. Here, we investigated risk factors for thrombophilia which were screened in young adult patients presenting with thrombotic events or with recurrent abortions with unknown etiology. A total of 115 patients aged between 16 and 50 years who were found to harbor thrombophilia were retrospectively evaluated. The laboratory investigations performed for the assessment of thrombophilia included protein C, protein S, antithrombin III deficiencies, activated protein C resistance, factor V Leiden (FVL), prothrombin 20210A (PT 20210) and methylenetetrahydrofolate reductase (MTHFR) gene mutations, factor VIII elevation, lupus anticoagulant ... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3027959 Wed, 25 Nov 2009 00:00:00 +0100 3027959 http://www.medworm.com/index.php?rid=3027969&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19936875%26dopt%3DAbstract Authors: Sakaki H, Kanegane H, Nomura K, Goi K, Sugita K, Miura M, Ishii E, Miyawaki T PMID: 19936875 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3027969 Sat, 21 Nov 2009 00:00:00 +0100 3027969 http://www.medworm.com/index.php?rid=3027966&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19936876%26dopt%3DAbstract In conclusion, high-dose chemotherapy with tandem auto-PBSCT is feasible and safe with a favorable response rate in treating advanced multiple myeloma in Japan. PMID: 19936876 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3027966 Sat, 21 Nov 2009 00:00:00 +0100 3027966 http://www.medworm.com/index.php?rid=3027965&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19936877%26dopt%3DAbstract Authors: Kobayashi S, Obata M, Hagihara M, Motohashi K, Ito S, Ohshima R, Sakai R, Maruta A, Kanamori H We observed the mature granulocytes/monocytes derived from leukemic cells in patients with acute myeloid leukemia who present mixed lineage leukemia gene (MLL). Morphologic observation and fluorescence in situ hybridization analysis (FISH) for chromosome 11q23 abnormality were studied, and a multiplex reverse transcriptase-polymerase chain reaction (RT-PCR) analysis was done to identify the fusion partners with MLL. The bone marrow cells with FISH signals of MLL showed the cell differentiation of the myeloid and/or monocytic lineages in 4 of 6 AML patients. MLL partner genes were AF6, AF9, ELL, and ENL, respectively. There was no correlation between the fusion partner and the appeara... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3027965 Fri, 20 Nov 2009 00:00:00 +0100 3027965 http://www.medworm.com/index.php?rid=3027964&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19936878%26dopt%3DAbstract We report a 47-year-old man with ENKL of the small intestine. He was referred to our hospital because of bloody stool and the diagnosis was made by double-balloon endoscopy (DBE) of the small intestine without surgical procedure. His clinical stage was IVB and he was categorized in group 4 by prognostic index of ENKL. He went into complete remission (CR) after intensive chemotherapy (DeVIC) and subsequently underwent allogeneic bone marrow transplantation (BMT). Although he remained in CR for about 8 months after BMT, he died of disease recurrence 14 months after the diagnosis was made. ENKL of the small intestine follows a highly aggressive course. We describe the usefulness of DBE for diagnosis and management for ENKL of the small intestine. Additional cases, however, should be accumulat... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3027964 Fri, 20 Nov 2009 00:00:00 +0100 3027964 http://www.medworm.com/index.php?rid=3004795&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19915946%26dopt%3DAbstract In conclusion, we demonstrated that OSM and LIF can induce hepcidin expression mainly through the JAK/STAT pathways. Further studies are warranted to evaluate the clinical significance of OSM and LIF in the development of anemia in various inflammatory diseases. PMID: 19915946 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3004795 Sat, 14 Nov 2009 00:00:00 +0100 3004795 http://www.medworm.com/index.php?rid=3004794&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19915947%26dopt%3DAbstract Authors: Wada T, Yokoyama T, Nakagawa H, Asai E, Toga A, Sakakibara Y, Shibata F, Tone Y, Shimizu M, Toma T, Yachie A In chronic active Epstein-Barr virus (EBV) infection (CAEBV), ectopic EBV infection has been described in T or natural killer (NK) cells. NK cell-type infection (NK-CAEBV) is characterized by large granular lymphocytosis, high IgE levels and unusual reactions to mosquito bites, including severe local skin reactions, fever and liver dysfunction. However, the mechanisms underlying these reactions remain undetermined. Herein, we describe a patient with NK-CAEBV whose blister fluid after mosquito bites was analyzed. The patient exhibited significant increases in the percentage of CD56(+) NK cells in the fluid compared with a simple mosquito allergy, in which the majority of... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=3004794 Sat, 14 Nov 2009 00:00:00 +0100 3004794 http://www.medworm.com/index.php?rid=2993083&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19904520%26dopt%3DAbstract Authors: Sumi M, Ichikawa N, Nasu K, Shimizu I, Ueki T, Ueno M, Kobayashi H A 56-year-old woman with acute myelomonocytic leukemia underwent myeloablative allogeneic hematopoietic stem cell transplantation (allo-SCT) from a matched unrelated donor in her first complete remission (CR). Veno-occlusive disease (VOD) prophylaxis consisted of low-dose heparin and ursodeoxycholic acid. Graft-versus-host disease (GVHD) prophylaxis comprised tacrolimus and short-term methotrexate. On day 14, VOD developed, but gradually resolved with supportive therapy. On day 58, she showed grade II acute GVHD, but this resolved spontaneously. On day 140, she developed hematological relapse with 40.2% marrow infiltration of CD33-positive blasts. Following the discontinuation of tacrolimus, gemtuzumab ozogamic... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2993083 Wed, 11 Nov 2009 00:00:00 +0100 2993083 http://www.medworm.com/index.php?rid=2955620&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19882376%26dopt%3DAbstract Authors: Lusher JM, Scharrer I The use of factor VIII (FVIII) concentrates in the treatment of hemophilia A has raised important safety issues, historically of pathogen transmission and increasingly of inhibitor development to FVIII treatment. While manufacturing processes of current recombinant FVIII products have been shaped entirely around preventing pathogen transmission, the same modifications that afford a greater margin of safety could affect immunogenicity of the product, consequences of which could only be seen through long-term clinical experience. This review summarizes pathogen safety and inhibitor reports from clinical trials, post-marketing surveillance studies, and study reports on KOGENATE((R)) and its successor, Kogenate((R)) FS/Bayer. Although KOGENATE and Kogenate FS... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2955620 Tue, 03 Nov 2009 00:00:00 +0100 2955620 http://www.medworm.com/index.php?rid=2946761&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19876705%26dopt%3DAbstract Authors: Shah BK, Serban K, Tandon M PMID: 19876705 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2946761 Sat, 31 Oct 2009 00:00:00 +0100 2946761 http://www.medworm.com/index.php?rid=2946763&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19866336%26dopt%3DAbstract Authors: Oshima K, Kikuchi A, Mochizuki S, Yamane M, Date H, Hanada R PMID: 19866336 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2946763 Thu, 29 Oct 2009 00:00:00 +0100 2946763 http://www.medworm.com/index.php?rid=2946762&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19866337%26dopt%3DAbstract We report the case of a 3-year-old boy with CGD, who developed IA despite antifungal prophylaxis. His treatment consisted of a 10-month-long multi-drug antifungal therapy, together with surgery, but these did not cause any substantial clinical improvement. BMT in high-risk patients with CGD remains a challenge due to both, higher risk of graft rejection and inflammatory flare in the course of immune recovery. Our patient rejected the first matched unrelated donor (MUD) allograft after RIC regimen recommended by the EBMT Inborn Errors Working Party for high-risk patients. After treosulfan-based conditioning and second MUD peripheral blood stem cell transplantation both, full reconstitution of the granulocytic series and complete recovery from IA, were achieved. PMID: 19866337 [PubMed - ... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2946762 Thu, 29 Oct 2009 00:00:00 +0100 2946762 http://www.medworm.com/index.php?rid=2939786&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19862602%26dopt%3DAbstract Authors: Viprakasit V, Lee-Lee C, Chong QT, Lin KH, Khuhapinant A Worldwide, thalassemia is the most commonly inherited hemolytic anemia, and it is most prevalent in Asia and the Middle East. Iron overload represents a significant problem in patients with transfusion-dependent beta-thalassemia. Chelation therapy with deferoxamine has traditionally been the standard therapeutic option but its usage is tempered by suboptimal patient compliance due to the discomfort and demands associated with the administration regimen. Therefore, a great deal of attention has been focused on the development of oral chelating agents. Deferiprone, even though available for nearly two decades in Asia with recent encouraging data on cardiac iron removal and long-term efficacy, has serious adverse effects in... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2939786 Thu, 29 Oct 2009 00:00:00 +0100 2939786 http://www.medworm.com/index.php?rid=2939787&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19859652%26dopt%3DAbstract Authors: Tamai H, Inokuchi K, Dan K, Tanosaki S PMID: 19859652 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2939787 Tue, 27 Oct 2009 00:00:00 +0100 2939787 http://www.medworm.com/index.php?rid=2931601&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19856041%26dopt%3DAbstract We report the first case of Mikulicz's disease (MD) occurring 2 years after autologous peripheral blood stem cell transplantation (PBSCT) for multiple myeloma (MM). A 70-year-old man developed bilateral enlargement of parotid and submandibular glands. The patient had previously received 2 courses of autologous PBSCT for IgG-kappa type MM, and had been stable for 2 years. This salivary gland enlargement was initially felt to represent a recurrence of MM, since along with gland swelling, IgG was also elevated. However, repeated biopsy of the left submandibular gland revealed chronic sclerosing sialadenitis rather than plasmacytoma. Results of salivary gland scintigraphy, serological testing, and absence of sicca symptoms also supported the diagnosis of MD. Concurrently, the patient developed... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2931601 Sat, 24 Oct 2009 00:00:00 +0100 2931601 http://www.medworm.com/index.php?rid=2906718&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19838867%26dopt%3DAbstract Authors: Kimura SI, Odawara J, Aoki T, Yamakura M, Takeuchi M, Matsue K We investigated the diagnostic utility of Aspergillus galactomannan (GM) in sputum for diagnosis of invasive pulmonary aspergillosis (IPA) in haematologic patients and compared the results with those of bronchial lavage fluid (BLF) and serum. Patients were classified into 4 groups using modified European Organization for Research and Treatment of Cancer criteria: group A, proven IPA; group B, probable IPA; group C, possible IPA; group D, others. Groups A and B were considered the IPA group (n = 6); group D was considered non-IPA group (n = 37); group C (n = 13) was equivocal for IPA. As a true negative control, sputa from patients with community-acquired pneumonia (CAP) without risk factors (group E, n = 22) were u... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2906718 Mon, 19 Oct 2009 23:00:00 +0100 2906718 http://www.medworm.com/index.php?rid=2906719&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19838769%26dopt%3DAbstract Authors: Kudrnová Z, Kvasnička J, Kudrna K, Mazoch J, Malíková I, Zenáhlíková Z, Sudrová M, Brzežková R Twenty-three patients with fondaparinux prophylaxis over 75 years of age who underwent hip fracture surgery were enrolled in the study. Fondaparinux sodium (2.5 mg) was administered subcutaneously 6 h postoperatively and then every 24 h for 28 days. Coagulation and inflammatory parameters were measured preoperatively, then 10 h, 2, 7, and 28 days postoperatively. Increased D: -dimers, positive acute phase proteins, and IL-6, and decreased negative acute phase proteins were observed preoperatively (P < 0.05). Maximum values were reached 10 h postoperatively for IL-6 and D: -dimer, and on postoperative days 2 and 7 for positive acu... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2906719 Fri, 16 Oct 2009 23:00:00 +0100 2906719 http://www.medworm.com/index.php?rid=2899480&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19826897%26dopt%3DAbstract Authors: Yamanouchi J, Hato T, Tamura T, Fujiwara H, Yakushijin Y, Yasukawa M PMID: 19826897 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2899480 Tue, 13 Oct 2009 23:00:00 +0100 2899480 http://www.medworm.com/index.php?rid=2899479&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19826898%26dopt%3DAbstract Authors: Fujiwara S, Miyake H, Nosaka K, Yoshida M, Ishihara S, Horikawa K, Yonemura Y, Iyama K, Mitsuya H, Asou N Hairy cell leukemia (HCL) is occasionally misdiagnosed as aplastic anemia when only a few leukemic cells are present in the circulation. Here, we describe a patient with HCL who initially presented with pancytopenia and received a diagnosis of aplastic anemia. The patient was treated with immunosuppressive therapy including cyclosporine A and anti-thymocyte globulin (ATG). No blood cell transfusion was required for approximately 3 years after ATG therapy. She was referred to our hospital because of an abdominal mass and requiring periodic blood transfusions. A bone marrow biopsy at this time revealed proliferation of lymphocytes with a fried egg appearance and an increase ... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2899479 Tue, 13 Oct 2009 23:00:00 +0100 2899479 http://www.medworm.com/index.php?rid=2880219&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19816666%26dopt%3DAbstract Authors: Horino S, Rikiishi T, Niizuma H, Abe H, Watanabe Y, Onuma M, Hoshi Y, Sasahara Y, Yoshinari M, Kazama T, Hayashi Y, Kumaki S, Tsuchiya S Immune thrombocytopenic purpura (ITP) has been associated with several hematologic malignancies such as Hodgkin and non-Hodgkin lymphomas and chronic lymphocytic leukemia, but it is rare in children with acute lymphoblastic leukemia (ALL). Here, we report a 7-year-old girl with chronic ITP during early intensive phase of chemotherapy for ALL. She underwent splenectomy because thrombocytopenia had persisted even after treatment with intravenous immunoglobulin (IVIG), steroids, vincristine, rituximab, and anti-D antibody. After splenectomy, her platelet count had recovered, and maintenance therapy could be resumed with a support of IVIG. To our... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2880219 Fri, 09 Oct 2009 23:00:00 +0100 2880219 http://www.medworm.com/index.php?rid=2866543&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19802732%26dopt%3DAbstract Authors: Fujimoto K, Endo T, Nishio M, Obara M, Yamaguchi K, Takeda Y, Goto H, Kasahara I, Sato N, Koike T A 44-year-old female presented with asymptomatic leukocytosis and moderate splenomegaly. The diagnosis of splenic marginal zone lymphoma (SMZL) was made by a splenectomy. A virological examination revealed the patient to be a hepatitis B virus (HBV) carrier. The lymphocyte count in her peripheral blood decreased after splenectomy, but remained high for 2 years and bone marrow infiltration was obvious. Two years after the splenectomy, she was admitted for an acute flare-up of hepatitis B. The liver dysfunction improved without any medication and thereafter returned to the normal range within a few weeks. At the same time, the lymphocyte count in her peripheral blood rapidly decreas... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2866543 Mon, 05 Oct 2009 23:00:00 +0100 2866543 http://www.medworm.com/index.php?rid=2832840&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19777196%26dopt%3DAbstract Authors: Lampronti I, Bianchi N, Zuccato C, Dall'acqua F, Vedaldi D, Viola G, Potenza R, Chiavilli F, Breveglieri G, Borgatti M, Finotti A, Feriotto G, Salvatori F, Gambari R The aim of the present study was to identify molecular analogs of angelicin (ANG) able to increase erythroid differentiation of K562 cells and expression of gamma-globin genes in human erythroid precursor cells, with low effects on apoptosis. ANG-like molecules are well-known photosensitizers largely used for their antiproliferative activity in the treatment of different skin diseases (i.e., psoriasis, vitiligo, eczema, and mycosis fungoides). To verify the activity of these derivatives, we employed three experimental cell systems: (1) the human leukemic K562 cell line, (2) K562 cell clones stably transfected with... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2832840 Thu, 24 Sep 2009 23:00:00 +0100 2832840 http://www.medworm.com/index.php?rid=2832839&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19779766%26dopt%3DAbstract Authors: Imashuku S, Kinugawa N, Matsuzaki A, Kitoh T, Ohki K, Shioda Y, Tsunematsu Y, Imamura T, Morimoto A, Langerhans cell histiocytosis (LCH) can be a single system or multi-system disease. Both disease types can be associated with multi-focal bone lesions, but their bone involvement patterns have not been compared systematically. Of the new pediatric LCH cases enrolled into the JLSG-02 study during 2002-2007, 67 cases of single system multifocal bone (SMFB) LCH and 97 cases of multi-system bone (MSB) LCH were analyzed to determine if the bone involvement patterns differ in these two types, and whether these differences correlate with outcome. Statistical analysis was performed with Mann-Whitney U test, Fisher's exact test, and other measures. Onset ages were higher for SMFB (P &l... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2832839 Thu, 24 Sep 2009 23:00:00 +0100 2832839 http://www.medworm.com/index.php?rid=2818988&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19768519%26dopt%3DAbstract Authors: Watanabe S, Miyake K, Ogawa C, Matsumoto H, Yoshida K, Hirabayashi S, Hasegawa D, Inoue T, Kizu J, Machida R, Ohara A, Hosoya R, Manabe A Patients with acute lymphoblastic leukemia (ALL), who develop antiasparaginase antibodies without clinical allergic reactions ("silent inactivation") during L: -asparaginase (L: -Asp) treatment, have poor outcomes. Ammonia is produced by hydrolysis of asparagine by L: -Asp. We postulated that plasma ammonia level might reflect the biological activity of L: -Asp. Five children with ALL treated according to the Tokyo Children's Cancer Study Group (TCCSG) protocol were enrolled. Plasma ammonia levels were analyzed immediately and 1 h after incubation at room temperature and "ex vivo ammonia production" was defined as increase in ammonia concent... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2818988 Fri, 18 Sep 2009 23:00:00 +0100 2818988 http://www.medworm.com/index.php?rid=2808198&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19760482%26dopt%3DAbstract Authors: Tanna S, Ustun C Acquired pure red cell aplasia (PRCA) can be primary or secondary to other diseases. PRCA association with chronic myelomonocytic leukemia (CMML) is very rarely reported. Although treatment is directed to underlying cause in secondary PRCA treatment, optimal treatment in patients with CMML and PRCA is unknown, because only four case reports are available. In addition, the effect of hypomethylating agents can be detrimental due to myelosuppression, at least in the early phase of treatment. Bone marrow examination of a 66-year-old woman with severe anemia revealed PRCA and was suspicious for CMML. There was no HLA-matched sibling for bone marrow transplantation. The patient received immunosuppressive therapy with steroids and cyclosporine with temporary response... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2808198 Thu, 17 Sep 2009 23:00:00 +0100 2808198 http://www.medworm.com/index.php?rid=2808199&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19756921%26dopt%3DAbstract Authors: Hayashi T, Morishita E, Ohtake H, Oda Y, Asakura H, Nakao S Annexin II is a receptor of tissue-type plasminogen activator (t-PA). We have previously identified annexin II by immunolocalization in human atherosclerotic abdominal aortic aneurysms (AAAs). To investigate possible interactions between annexin II and AAA development, we examined annexin II mRNA and protein expression in a rat model of experimental AAA. AAAs were induced in rats by transient aortic infusion of elastase. The rats were divided into three groups: a saline-treated control group, a group with 15-min elastase infusion, and a group with 30-min elastase infusion. The 15-min elastase-infused group had smaller aneurysms and more preserved media than the 30-min elastase-infused group. Immunohistochemistry showe... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2808199 Tue, 15 Sep 2009 23:00:00 +0100 2808199 http://www.medworm.com/index.php?rid=2808200&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19756920%26dopt%3DAbstract We report here the clinical and biologic courses of two HIV-negative, HHV8-positive patients with MCD who were treated with rituximab. In both cases, a significant clinical improvement was observed after the first two infusions, which was shortly followed by a drop in HHV8 viremia to undetectable levels. Both patients underwent complete clinical remission, which persisted without relapse at 30 and 9 months of follow-up, respectively. No reactivation of the Kaposi sarcoma found in a lymph node of one of the patients was observed. Our report, along with additional data present in the literature, suggests that rituximab may be an appropriate and safe first-line therapy for HIV-negative, HHV8-positive MCD. PMID: 19756920 [PubMed - as supplied by publisher] (Source: International Journal of... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2808200 Fri, 11 Sep 2009 23:00:00 +0100 2808200 http://www.medworm.com/index.php?rid=2769171&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19728022%26dopt%3DAbstract Authors: Ohashi H, Arita K, Fukami S, Oguri K, Nagai H, Yokozawa T, Hotta T, Hanada S PMID: 19728022 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2769171 Tue, 01 Sep 2009 23:00:00 +0100 2769171 http://www.medworm.com/index.php?rid=2769170&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19728023%26dopt%3DAbstract In this study, we analyzed neutrophil function in children with acute lymphoblastic leukemia (ALL). Whole blood samples were obtained from 16 children with ALL at diagnosis, after induction chemotherapy, and after consolidation chemotherapy. Oxidative burst and phagocytic activity of neutrophils were analyzed by flow cytometry. Oxidative burst of neutrophils was impaired in ALL patients. The percentage of neutrophils with normal oxidative burst after PMA stimulation was 59.0 +/- 13.2 or 70.0 +/- 21.0% at diagnosis or after induction chemotherapy, respectively, which was significantly lower compared with 93.8 +/- 6.1% in healthy control subjects (P = 0.00004, or 0.002, respectively); however, this value was normal after consolidation chemotherapy. No significant differences were noted in ph... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2769170 Tue, 01 Sep 2009 23:00:00 +0100 2769170 http://www.medworm.com/index.php?rid=2769165&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19728028%26dopt%3DAbstract Authors: Tong H, Ren Y, Qian W, Xiao F, Mai W, Meng H, Jin J We reviewed 173 patients with an initial diagnosis of peripheral T-cell non-Hodgkin lymphoma (PTCL) and compared the patients with bone marrow involvement (BMI) to those without to have a better understanding of the clinical characteristics, treatments, survival and prognosis of PTCLs with BMI. We found that 40% (70/173) of the patients had BMI, and its frequency was 64% in angioimmunoblastic T-cell lymphoma (TCL), 46% in PTCL unspecified, 29% in anaplastic large T-cell lymphoma, 23% in extranodal NK/T-cell lymphoma and 13% in enteropathy-type TCL. In the BMI group, 36% of patients had lymphoma-associated hemophagocytic syndrome (LAHS), compared with 8% of the patients without BMI (8/103, P < 0.001). The estimated 1-year o... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2769165 Tue, 01 Sep 2009 23:00:00 +0100 2769165 http://www.medworm.com/index.php?rid=2769174&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19728019%26dopt%3DAbstract Authors: Miura K, Hatta Y, Kobayashi S, Iriyama Y, Takei K, Takeuchi J PMID: 19728019 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2769174 Fri, 28 Aug 2009 23:00:00 +0100 2769174 http://www.medworm.com/index.php?rid=2769173&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19728020%26dopt%3DAbstract Authors: Yujiri T, Tanaka Y, Tanaka M, Tanizawa Y PMID: 19728020 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2769173 Fri, 28 Aug 2009 23:00:00 +0100 2769173 http://www.medworm.com/index.php?rid=2769172&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19728021%26dopt%3DAbstract Authors: Kasahara I, Nishio M, Yamamoto S, Endo T, Fujimoto K, Yamaguchi K, Takeda Y, Goto H, Sato N, Koike T Two multiple myeloma patients relapsed after autologous stem cell transplantation (ASCT). Conventional chemotherapy, including thalidomide, showed very little effect, but both patients responded well to a standard dose of bortezomib. One patient was treated with two additional cycles of bortezomib, but his clinical course suddenly deteriorated. Unrelated cord blood transplantation (CBT) with reduced-intensity conditioning regimen (RIC) was performed in refractory disease. After CBT, the clinical course was aggravated by tumor lysis syndrome and other conditions, thus resulting in patient death on day 34. Thereafter, we administered CBT with RIC on the second patient after just ... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2769172 Fri, 28 Aug 2009 23:00:00 +0100 2769172 http://www.medworm.com/index.php?rid=2769169&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19728024%26dopt%3DAbstract We describe cytogenetic abnormalities in 172 patients with ET at a single institution. At presentation nine (5.2%) patients had cytogenetic abnormality and three (1.7%) additional patients acquired them during follow-up. Survival of patients with cytogenetic changes at presentation did not differ when compared to the patients with normal karyotype. The more common were abnormalities of chromosome 9 (n = 4), 20 (n = 2), 5 (n = 2), and complex abnormalities (n = 2). Forty-one patients (23.8%) had additional cytogenetic tests performed for monitoring purposes during follow-up. Five patients (2.9%) with normal karyotype transformed to myelofibrosis (MF) without developing new cytogenetic changes at transformation. Two patients (1.2%) with normal karyotypes at presentation transformed to myelod... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2769169 Fri, 28 Aug 2009 23:00:00 +0100 2769169 http://www.medworm.com/index.php?rid=2769168&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19728025%26dopt%3DAbstract Authors: Li S, Xue F, Cheng Z, Yang X, Wang S, Geng F, Pan L The initial treatment of multiple myeloma (MM) experienced a paradigm shift, in the past decade, with the introduction of novel agents such as thalidomide, lenalidomide and bortezomib, leading to improved outcomes. High dose therapy and autologous stem cell transplantation remain an important therapeutic option for patients with MM eligible for the procedure. However, most of these treatment regimens are too expensive for Chinese patients. Therefore, we investigated the effects of artesunate, which is commonly used in the treatment of severe malaria, on inhibition of proliferation and induction of apoptosis of a mouse myeloma cell line SP2/0. The growth inhibition of SP2/0 cell proliferation induced by artesunate (ART) treatm... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2769168 Fri, 28 Aug 2009 23:00:00 +0100 2769168 http://www.medworm.com/index.php?rid=2769167&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19728026%26dopt%3DAbstract Authors: Takemura Y, Ikeda M, Kobayashi K, Nakazawa Y, Mori Y, Mitsuishi T, Ishigame H, Kameko F, Fujita K, Ichinohasama R A 78-year-old male with lumbar pain and dim consciousness presented the clinical pictures of plasma cell leukemia (PCL) producing a large amount of monoclonal immunoglobulin E (IgE)/kappa protein. Laboratory investigation demonstrated an elevated serum calcium level and renal dysfunction. Systemic bone X-ray survey disclosed only a solitary osteolytic lesion. Circulating plasma cells demonstrated CD19(-)/CD56(-) and MPC-1(-)/CD49e(-)/CD45(+/-), the latter indicating the immature phenotype of the tumor cells. Bone marrow was occupied with immature, atypical plasma cells, of which cytoplasms were positive for IgE by direct immunofluorescence analysis. Chromosomes rev... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2769167 Fri, 28 Aug 2009 23:00:00 +0100 2769167 http://www.medworm.com/index.php?rid=2769166&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19728027%26dopt%3DAbstract Authors: Wang XQ, Ryder J, Gross SA, Lin G, Irons RD We characterized the prevalence, clinical and cytogenetic characteristics and survival of 435 patients diagnosed with de novo MDS in a single laboratory according to WHO criteria, and compared the utility of different scoring systems to predict survival for individual subtypes of MDS. The mean follow-up period was 25.1 (5.5-53.2) months. Our results confirm major differences in the age-distribution and prevalence of individual subtypes of MDS between Asian and Western patients with a median age of 58 years and a predominance of RCMD (69.9%). Survival rates were similar to those reported in the West: the 3-year survival rate for MDS was 46.7% with a median survival time for RCMD of 38 months and RAEB, 10 months. We found that the IPSS... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2769166 Fri, 28 Aug 2009 23:00:00 +0100 2769166 http://www.medworm.com/index.php?rid=2769164&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19728029%26dopt%3DAbstract Authors: Björklund E, Gruber A, Mazur J, Mårtensson A, Hansson M, Porwit A Fast development in polychromatic flow cytometry (PFC) makes it possible to study CD34+ cells with two scatter and eight fluorescence parameters. Minimal residual disease (MRD) is determined as persistence of leukemic cells at submicroscopic levels in bone marrow (BM) of patients in complete remission. MRD can be present in collections of hematopoietic stem cell from blood (HSC-B). Using PFC, we have defined patterns of antigen expression in CD34+ cell subpopulations in BM and applied them as templates in MRD analysis. Twelve BM samples from hospital control (HC) patients with no signs of hematological malignancy were studied using five 8-color monoclonal antibody combinations detecting subsets of CD34... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2769164 Fri, 28 Aug 2009 23:00:00 +0100 2769164 http://www.medworm.com/index.php?rid=2738515&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19707712%26dopt%3DAbstract We report a patient who has primary cutaneous anaplastic large cell (C-ALCL) with an unusual presentation as a vulvar ulcer. She received a brief course of chemotherapy followed by local irradiation and has remained disease-free more than a year from the time of diagnosis. To our knowledge, primary C-ALCL involving the vulva has never been reported. Despite its typical cutaneous manifestation of C-ALCL, the uncommon presenting site of this entity warrants recognition because of its prognostic and therapeutic implication. PMID: 19707712 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2738515 Tue, 25 Aug 2009 23:00:00 +0100 2738515 http://www.medworm.com/index.php?rid=2738518&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19705055%26dopt%3DAbstract Authors: Morio T, Takahashi N, Watanabe F, Honda F, Sato M, Takagi M, Imadome KI, Miyawaki T, Delia D, Nakamura K, Gatti RA, Mizutani S A nationwide survey was conducted for identifying ataxia-telangiectasia (AT) patients in Japan. Eighty-nine patients were diagnosed between 1971 and 2006. Detailed clinical and laboratory data of 64 patients including affected siblings were collected. Analyses focused on malignancy, therapy-related toxicity, infection, and hematological/immunological parameters. The phenotypic variability of AT was assessed by comparing 26 affected siblings from 13 families. Malignancy developed in 22% of the cases and was associated with a high rate of severe therapy-related complications: chemotherapy-related cardiac toxicity in 2 children, and severe hemorrhagic cys... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2738518 Mon, 24 Aug 2009 23:00:00 +0100 2738518 http://www.medworm.com/index.php?rid=2738517&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19705056%26dopt%3DAbstract Authors: Miyamura F, Kako S, Yamagami H, Sato K, Sato M, Terasako K, Kimura SI, Nakasone H, Aoki S, Okuda S, Yamazaki R, Oshima K, Yoshinaga K, Higuchi T, Nishida J, Demitsu T, Kakehashi A, Kanda Y Only some carriers of human T cell lymphotropic virus type I (HTLV-1) develop adult T cell leukemia/lymphoma (ATLL) after a long latency period, and an association has been reported between chronic refractory eczema, known as infective dermatitis, and young-onset ATLL. A 25-year-old female developed ATLL and underwent allogeneic hematopoietic stem cell transplantation (HSCT) in non-remission. She had chronic refractory eczema and corneal injury at the onset of ATLL. Remission of ATLL was achieved, and the HTLV-1 proviral load decreased after HSCT. In addition, her pre-existing eczema and cor... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2738517 Mon, 24 Aug 2009 23:00:00 +0100 2738517 http://www.medworm.com/index.php?rid=2738516&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19705057%26dopt%3DAbstract Authors: Harada H, Watanabe M, Suzuki K, Yanagita S, Suzuki T, Yoshida Y, Kimura A, Tsudo M, Matsuda A, Tohyama K, Taniwaki M, Takeshita K, Takatoku M, Ozawa K Lenalidomide is an immunomodulatory agent recently reported to be effective in the treatment of transfusion-dependent anemia due to low- or intermediate-1 risk myelodysplastic syndromes (MDS) associated with a deletion 5q (del 5q) cytogenetic abnormality. We conducted a multicenter, single-arm clinical trial to evaluate the safety and efficacy of lenalidomide in Japanese patients with anemia in low- or intermediate-1 risk MDS associated with the del 5q cytogenetic abnormality. Eleven patients (5 with transfusion-dependent anemia; 6 with transfusion-independent symptomatic anemia) received once daily oral administrations of 10 mg... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2738516 Mon, 24 Aug 2009 23:00:00 +0100 2738516 http://www.medworm.com/index.php?rid=2731051&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19701676%26dopt%3DAbstract This study in Japanese patients evaluated the efficacy, safety, and pharmacokinetic profile of rasburicase in pediatric patients with hematologic malignancies. Patients aged <18 years at high risk for TLS, with newly diagnosed hematologic malignancies, were randomized to intravenous rasburicase 0.15 mg/kg/day (n = 15) or 0.20 mg/kg/day (n = 15) for 5 days. Chemotherapy was started 4-24 h after the first rasburicase dose. Response was defined as a reduction in plasma uric acid to </=6.5 mg/dL (patients <13 years) or </=7.5 mg/dL (patients >/=13 years) by 48 h after the first administration, lasting until 24 h after the final administration. Response rates were 93.3 and 100% with rasburicase 0.15 and 0.20 mg/kg/day, respectively. Uric acid levels declined rapidly within 4 h of... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2731051 Fri, 21 Aug 2009 23:00:00 +0100 2731051 http://www.medworm.com/index.php?rid=2731050&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19701677%26dopt%3DAbstract Authors: Latagliata R, Rago A, Spadea A, Santoro C, Carmosino I, Breccia M, Napoleone L, Fama A, Biondo F, Volpicelli P, Vozella F, Stefanizzi C, Petti MC, Alimena G, Mazzucconi MG We prospectively tested, at diagnosis in essential thrombocythemia (ET) patients with no clear indication to platelet (PLT)-lowering treatment, a scoring system based on age, PLT level, cardiovascular diseases, previous thrombotic events, smoking and dysmetabolic diseases. From 04/92 to 03/98, 168 consecutive patients were enrolled. Hydroxyurea (HU) was started at diagnosis in 32 "symptomatic" patients and in 33 patients aged >70 years. The remaining 103 patients ("asymptomatic" and aged <70 years) were classified according to our scoring system. Thirty-two patients with score >/=4 started HU early ... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2731050 Fri, 21 Aug 2009 23:00:00 +0100 2731050 http://www.medworm.com/index.php?rid=2725648&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19697098%26dopt%3DAbstract We report here for the first time three AML cases that relapsed after allogeneic SCT and underwent unrelated cord blood transplantation (UCBT) following reduced-intensity conditioning (RIC) comprising fludarabine, melphalan, and low-dose total body irradiation combined with GO. Primary neutrophil engraftment occurred in all cases, while recovery of platelet count was delayed. Only one case of reversible hepatic sinusoidal obstruction syndrome was documented. Non-relapse mortality at day 100 was not documented. Notably, one patient who responded to GO survived for 6 months after UCBT in remission with excellent performance status, while the remaining cases relapsed early. These data suggest that GO may be safely combined with RIC for UCBT after previous allogeneic SCT. PMID: 19697098 [P... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2725648 Fri, 21 Aug 2009 23:00:00 +0100 2725648 http://www.medworm.com/index.php?rid=2725647&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19697099%26dopt%3DAbstract In conclusion, in this study donor-donor mixed chimerism was common after high dose ATG and DCBT. Further studies are warranted concerning the immunological consequences of the phenomenon of donor-donor mixed chimerism after DCBT. PMID: 19697099 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2725647 Fri, 21 Aug 2009 23:00:00 +0100 2725647 http://www.medworm.com/index.php?rid=2723044&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19693450%26dopt%3DAbstract We report herein a rare case of myelodysplastic syndrome (MDS-RAEB) complicated by severe PAP, and successful allogeneic bone marrow transplantation (BMT) for both disorders. An unrelated BMT was planned for a 48-year-old male with advanced MDS-RAEB. Just before the initiation of the conditioning regimen for unrelated BMT in March 2007, he developed dyspnea. A diagnosis of PAP was made based on findings of chest X-ray, CT scanning, and the fluid obtained by bronchoalveolar lavage. To improve his dyspnea and improve BMT safety, whole lung lavage (WLL) was performed twice, with the partial improvement of PAP. Unrelated allogeneic BMT was performed in September 2007. We had to perform a third WLL because of the worsening of PAP on day 26 after BMT. Despite many infectious complications after ... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2723044 Wed, 19 Aug 2009 23:00:00 +0100 2723044 http://www.medworm.com/index.php?rid=2723043&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19693451%26dopt%3DAbstract We report a case of donor cell-derived acute lymphocytic leukemia (ALL) occurring in a 55-year-old man after allogeneic bone marrow transplantation (allo-BMT) from an HLA-matched unrelated donor for refractory multiple myeloma (MM). Molecular analysis using short tandem repeat sequences proved the ALL to be of donor origin. He underwent combination chemotherapy and second allo-BMT from an alternative donor. After second allo-BMT, extramedullary myeloma relapsed as tumor, but was successfully treated with proteasome inhibitor, bortezomib. However, he died from severe graft-versus-host disease four months after the second transplantation. Although more than 50 cases of DCL have been reported, there have been only two reports of DCL developed in MM patients including our case. This rare compl... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2723043 Wed, 19 Aug 2009 23:00:00 +0100 2723043 http://www.medworm.com/index.php?rid=2716638&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19688235%26dopt%3DAbstract Authors: Arima K, Hasegawa D, Ogawa C, Kato I, Imamura T, Takusagawa A, Takahashi H, Kitagawa Y, Hori T, Tsurusawa M, Manabe A, Hosoya R Testicular relapse has an impact on the prognosis of boys with acute lymphoblastic leukemia (ALL). Because isolated testicular relapse often precedes hematological relapse, systemic therapy is required in addition to local therapy. However, a rationale for the use of a combination of systemic chemotherapy and local therapy is unclear. A 12-year-old boy with T-ALL suffered from isolated testicular relapse at 27 months after diagnosis. He was successfully treated with systemic chemotherapy with orchiectomy and prophylactic irradiation to the contralateral testis. We retrospectively estimated the minimal residual disease in the bone marrow (BM) and the t... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2716638 Mon, 17 Aug 2009 23:00:00 +0100 2716638 http://www.medworm.com/index.php?rid=2692791&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19669857%26dopt%3DAbstract Authors: Ohta H, Fukushima N, Ozono K Post-transplant lymphoproliferative disorder (PTLD) is a well recognized and potentially fatal complication after pediatric cardiac transplantation. PTLD encompasses a wide spectrum, ranging from benign hyperplasia to more aggressive lymphoma. Most cases are Epstein-Barr virus (EBV)-related B-cell tumors resulting from impaired immunity due to immunosuppressive therapy. Pediatric recipients, often seronegative for EBV at transplantation, have a greater risk for PTLD than adults. The clinical presentation of PTLD varies from isolated lymphadenopathy to systemic disease; common sites involved are gastrointestinal tract, lung or airway, and cervical lesions. Timely and accurate diagnosis based on histological examination of biopsy tissue is essential ... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2692791 Tue, 11 Aug 2009 23:00:00 +0100 2692791 http://www.medworm.com/index.php?rid=2692790&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19669858%26dopt%3DAbstract Authors: Sonmez M, Erkut N, Tat TS, Celep F, Cobanoglu U, Ersoz HO PMID: 19669858 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=2692790 Tue, 11 Aug 2009 23:00:00 +0100 2692790