MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'International Journal of Hematology' source. Wed, 08 Feb 2012 17:42:02 +0100 http://www.medworm.com/index.php?rid=5626828&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22270404%26dopt%3DAbstract In conclusion, elevated fibrinolysis induced by increased bleeding may lead to further increases in bleeding in patients receiving thromboprophylaxis with fondaparinux following major orthopedic surgery. PMID: 22270404 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5626828 Sat, 21 Jan 2012 05:00:00 +0100 5626828 http://www.medworm.com/index.php?rid=5626842&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22262140%26dopt%3DAbstract We report here a case involving a 28-year-old female patient with mycosis fungoides who underwent umbilical cord blood transplantation three times and developed CMV ventriculoencephalitis. The patient's CMV viremia was successfully preempted with ganciclovir (GCV) as indicated by undetectable CMV antigenemia; despite this successful treatment, the patient developed CMV ventriculoencephalitis. Foscarnet (FCV) therapy led to a temporary recovery, after which CMV ventriculoencephalitis recurred, and the patient died after receiving combination GCV and FCV therapy. Autopsy samples revealed CMV ventriculoencephalitis, as indicated by numerous inclusion-bearing cells (Owl's eye). It is likely that this patient harbored a GCV-resistant CMV strain; however, it was not possible to obtain nucleic ac... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5626842 Fri, 20 Jan 2012 05:00:00 +0100 5626842 http://www.medworm.com/index.php?rid=5626831&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22262141%26dopt%3DAbstract Authors: Itonaga H, Tsushima H, Hata T, Matsuo E, Imanishi D, Imaizumi Y, Kawaguchi Y, Fukushima T, Doi Y, Mori S, Kamihira S, Tomonaga M, Miyazaki Y Abstract The T315I BCR-ABL mutation in chronic myelogenous leukemia (CML) patients is responsible for up to 20% of all clinically observed resistance. This mutation confers resistance not only to imatinib, but also to second-generation BCR-ABL tyrosine kinases, such as nilotinib and dasatinib. A number of strategies have been implemented to overcome this resistance, but allogeneic stem cell transplantation remains the only established therapeutic option for a cure. A 61-year-old male was diagnosed with Philadelphia chromosome-positive chronic-phase CML in 2002. He was initially treated with imatinib and complete cytogenetic response (... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5626831 Fri, 20 Jan 2012 05:00:00 +0100 5626831 http://www.medworm.com/index.php?rid=5626858&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22258715%26dopt%3DAbstract In conclusion, these results suggest the following: (a) the EPCs derived from mouse bone marrow mononuclear cells express phenotypes characteristic of normal EPCs, (b) irradiation during preconditioning damaged the endothelium, which initiated mobilization of EPCs, and (c) injury to the endothelium also caused extrinsic EPCs home to the damaged tissue. PMID: 22258715 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5626858 Thu, 19 Jan 2012 05:00:00 +0100 5626858 http://www.medworm.com/index.php?rid=5580224&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22234527%26dopt%3DAbstract Authors: Watanaboonyongcharoen P, Nakorn TN, Rojnuckarin P, Lawasut P, Intragumtornchai T Abstract Individuals with monoclonal gammopathy of undetermined significance (MGUS) develop multiple myeloma and related malignancies at the rate of 1% per year. Given differences in ethnicity, data on prevalence and risk factors of MGUS in Thai population will be helpful in understanding the pathogenesis of plasma cell disorders and designing an early cancer detection strategy. Subjects of 50 years or older were included. Demographic data and suspected risk factors were collected. Monoclonal proteins were detected using serum protein electrophoresis. Serum was obtained from 3,260 participants; 1,104 males (33.9%) and 2,156 females (66.1%). The median age was 57 years (range 50-93 years). M... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5580224 Thu, 12 Jan 2012 05:00:00 +0100 5580224 http://www.medworm.com/index.php?rid=5580225&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22231992%26dopt%3DAbstract Authors: Miyazaki Y PMID: 22231992 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5580225 Wed, 11 Jan 2012 05:00:00 +0100 5580225 http://www.medworm.com/index.php?rid=5580223&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22234528%26dopt%3DAbstract Authors: Nikoloski G, van der Reijden BA, Jansen JH Abstract Until recently, the genetic aberrations that are causally linked to the pathogenesis of myelodysplastic syndromes (MDS) and myeloproliferative neoplasms were largely unknown. Using novel technologies like high-resolution SNP-array analysis and next generation sequencing, various genes have now been identified that are recurrently mutated. Strikingly, several of the newly identified genes (ASXL1, DNMT3A, EZH2, IDH1 and IDH2, and TET2) are involved in the epigenetic regulation of gene expression. Aberrant epigenetic modifications have been described in many types of cancer, including myeloid malignancies. It has been proposed that repression of genes that are crucial for the cessation of the cell cycle and induction of diff... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5580223 Wed, 11 Jan 2012 05:00:00 +0100 5580223 http://www.medworm.com/index.php?rid=5580226&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22222874%26dopt%3DAbstract Authors: Rouaud P, Guerin E, Bordessoule D, Turlure P, Trimoreau F, Denizot Y PMID: 22222874 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5580226 Sat, 07 Jan 2012 05:00:00 +0100 5580226 http://www.medworm.com/index.php?rid=5568725&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22218882%26dopt%3DAbstract Authors: Raaijmakers MH Abstract Myelodysplastic syndromes are a heterogeneous group of diseases characterized by ineffective hematopoiesis and the propensity to leukemic transformation. Their pathogenesis is complex and likely depends on interplay between aberrant hematopoietic cells and their microenvironment. How niche cells play a role in disease evolution is poorly defined, but the delineation of the hematopoietic stem cell niche and the ability to interrogate its role in hematopoietic disease in animal models have furthered our insights in recent years. The data support a view in which the microenvironment can play an active role in the evolution of myelodysplasia and myeloproliferative disorders, thus providing further rationale to explore therapeutic targeting of mesenchyma... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5568725 Fri, 06 Jan 2012 05:00:00 +0100 5568725 http://www.medworm.com/index.php?rid=5568724&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22218883%26dopt%3DAbstract Authors: Ornstein MC, Sekeres MA Abstract The myelodysplastic syndromes (MDS) consist of an array of clonal hematological malignancies resulting from disorders of pluripotent hematopoietic stem cells. MDS is associated with a poor overall prognosis and patients are categorized as higher risk and lower risk on the basis of the International Prognostic Scoring System. Currently, lenalidomide, azacitidine, and decitabine are the only three FDA-approved drugs for MDS. Traditional therapies for MDS involve the administration of single agents providing either supportive measures or disease-modifying effects directed to slowing progression to acute myeloid leukemia (AML) and improving survival. Recently, however, there has been increasing evidence suggesting that the combination of drugs ... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5568724 Fri, 06 Jan 2012 05:00:00 +0100 5568724 http://www.medworm.com/index.php?rid=5568726&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22215484%26dopt%3DAbstract Authors: Ney-Garcia DR, Liehr T, Bhatt S, de Souza MT, de Matos RR, Pimenta G, Pulcheri W, Ribeiro RC, Abdelhay E, Silva ML PMID: 22215484 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5568726 Thu, 05 Jan 2012 05:00:00 +0100 5568726 http://www.medworm.com/index.php?rid=5552891&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22205503%26dopt%3DAbstract Authors: Ichinose A, Souri M Abstract Coagulation factor XIII/13 (FXIII/13) stabilizes fibrin molecules by creating crosslinks with other fibrin molecules as well as with α(2)-plasmin inhibitor (α(2)-PI). "Hemorrhagic acquired FXIII/13 deficiency" was formerly considered rare, but has been increasing recently in Japan. During the 10 months of our nationwide campaign, we diagnosed five new patients with "acquired hemorrhaphilia due to anti-FXIII/13 autoantibodies," after examining 20 newly suspected cases of "hemorrhagic acquired FXIII/13 deficiency." When FXIII/13 activity was reduced to less than 50% of normal, it was proportional to the difference in α(2)-PI levels between plasma and serum (plasma-serum α(2)-PI), likely due to its cross-linking to fibrin by activated FXIII/1... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5552891 Thu, 29 Dec 2011 05:00:00 +0100 5552891 http://www.medworm.com/index.php?rid=5552890&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22205504%26dopt%3DAbstract In conclusion, our systematic analysis suggests that low ALC has an adverse effect on outcome in DLBCL. Although it should be borne in mind that this meta-analysis was mainly based on data abstracted from observational studies, these results may justify risk-adapted therapeutic strategies for DLBCL to account for ALC at diagnosis. PMID: 22205504 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5552890 Thu, 29 Dec 2011 05:00:00 +0100 5552890 http://www.medworm.com/index.php?rid=5552892&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22198829%26dopt%3DAbstract Authors: Iino M PMID: 22198829 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5552892 Tue, 27 Dec 2011 05:00:00 +0100 5552892 http://www.medworm.com/index.php?rid=5538813&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22189846%26dopt%3DAbstract In this study, we examined the clinical and biological characteristics of 11 Japanese patients with T-PLL. Median age was 74 years, with male predominance. Median lymphocyte frequency was 85.3% in blood. Physical characteristics were splenomegaly (36.4%), tiny lymph adenopathy (63.6%), skin lesion (9.1%) and pleural effusion (27.3%). Median survival was 30.1 months, despite treatment with various chemotherapeutic modalities. Although complex chromosomal abnormalities were observed in 5 of 11 cases (45.5%), typical 14q32 and Xq28 abnormalities were not detected. TCL1A mRNA expression was observed in 6 of 11 cases (54.5%) on real-time quantitative PCR. In 5 of these 6 cases, flow cytometric analysis and/or immunohistochemistry confirmed the expression of TCLA1 protein. Split signals for th... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5538813 Fri, 23 Dec 2011 05:00:00 +0100 5538813 http://www.medworm.com/index.php?rid=5538810&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22193844%26dopt%3DAbstract Authors: Taoka K, Kumano K, Nakamura F, Hosoi M, Goyama S, Imai Y, Hangaishi A, Kurokawa M Abstract We investigated the mechanisms of hematopoietic disorders caused by iron overload and chelation, in particular, the inhibition of erythroblast differentiation. Murine c-kit(+) progenitor cells or human CD34(+) peripheral blood hematopoietic progenitors were differentiated in vitro to the erythroid lineage with free iron and/or an iron chelator. Under iron overload, formation of erythroid burst-forming unit colonies and differentiation to mature erythroblasts were significantly suppressed; these effects were canceled by iron chelation with deferoxamine (DFO). Moreover, excessive iron burden promoted apoptosis in immature erythroblasts by elevating intracellular reactive oxygen species... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5538810 Fri, 23 Dec 2011 05:00:00 +0100 5538810 http://www.medworm.com/index.php?rid=5538812&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22189847%26dopt%3DAbstract Authors: Doki N, Kitaura J, Uchida T, Inoue D, Kagiyama Y, Togami K, Isobe M, Ito S, Maehara A, Izawa K, Kato N, Oki T, Harada Y, Nakahara F, Harada H, Kitamura T Abstract The Bcr-Abl oncogene causes human Philadelphia chromosome-positive (Ph(+)) leukemias, including B-cell acute lymphoblastic leukemia (B-ALL) and chronic myeloid leukemia (CML) with chronic phase (CML-CP) to blast crisis (CML-BC). Previous studies have demonstrated that Src family kinases are required for the induction of B-ALL, but not for CML, which is induced by Bcr-Abl in mice. In contrast, it has been reported that Fyn is up-regulated in human CML-BC compared with CML-CP, implicating Fyn in the blast crisis transition. Here, we aimed to delineate the exact role of Fyn in the induction/progression of Ph(+) leuk... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5538812 Thu, 22 Dec 2011 05:00:00 +0100 5538812 http://www.medworm.com/index.php?rid=5538816&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22180324%26dopt%3DAbstract Authors: Karimi M, Haghpanah S, Farhadi A, Yavarian M Abstract We evaluated the clinical responses to hydroxyurea (HU), adverse effects, and β-globin gene variants in a large series of β-thalassemic patients over a 13-year period in Iran. The patients (n = 232) were divided into two groups: transfusion-dependent β-thalassemia patients 2 years of age and older (n = 126; Group 1), and β-thalassemia intermedia (βTI) patients without any history of blood transfusion or with a long-interval transfusion (n = 106; Group 2). In Group 1, 86 patients became transfusion-free, and 25 patients needed 1-2 transfusions per year at the end of study. All except three patients in Group 2 were completely transfusion free with a significant increase in Hb level after 1 year compared to th... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5538816 Tue, 20 Dec 2011 05:00:00 +0100 5538816 http://www.medworm.com/index.php?rid=5538815&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22183779%26dopt%3DAbstract Authors: Herrmann R, Sturm M, Shaw K, Purtill D, Cooney J, Wright M, Phillips M, Cannell P Abstract Steroid-refractory acute graft versus host disease (AGVHD) and chronic graft versus host disease (CGVHD) after allogeneic haematopoietic stem cell transplantation are major causes of morbidity and mortality. We undertook a phase I trial in patients with steroid-refractory AGVHD and CGVHD utilising bone marrow-derived mesenchymal stromal cells (MSC). Additionally, all refractory patients were treated with etanercept concomitantly. The primary end point was safety, and secondary end points were best response achieved and overall survival. A median of two infusions per patient were administered. The response rate overall for AGVHD was complete in seven, partial in four and no response i... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5538815 Tue, 20 Dec 2011 05:00:00 +0100 5538815 http://www.medworm.com/index.php?rid=5538814&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22183780%26dopt%3DAbstract Authors: Hao L, Sun H, Wang J, Wang T, Wang M, Zou Z Abstract Mesenchymal stromal cells (MSC) have attracted the attention of scientists and clinicians due to their self-renewal, capacity for multipotent differentiation, and immunomodulatory properties. Some essential problems remain to be solved before the clinical application of MSC. Platelet lysate (PL) has recently been used as a substitute for FBS in MSC amplification in vitro to achieve clinically applicable numbers of MSC. In addition to promising trials in regenerative medicine, such as in the treatment of major bone defects and myocardial infarction, MSC have shown therapeutic effect other than direct hematopoiesis support in hematopoietic reconstruction. It has been confirmed that MSC promote hematopoietic cell engraftmen... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5538814 Tue, 20 Dec 2011 05:00:00 +0100 5538814 http://www.medworm.com/index.php?rid=5538811&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22193843%26dopt%3DAbstract Authors: El-Difrawy MM, Zaki NE, Marouf HM, Ayad MW, Farag AM Abstract Monoclonal antibodies are found in approximately 10% of patients with peripheral neuropathy (PN) of unknown etiology. Several autoantibodies, including anti-MAG (myelin-associated glycoprotein) antibodies, have been reported to induce neuropathy. It has been suggested that over 50% of patients with PN and IgM monoclonal gammopathy (MG) have anti-MAG IgM antibodies in their sera. This work aimed at studying the frequency and characteristics of PN in a group of Egyptian patients with MGs and to estimate the serum level of anti-MAG antibodies and its relationship to peripheral nerve dysfunction. Forty patients with MGs were enrolled in the study. Their mean age was 56.65 ± 8.55 years. There were 17 males and 23... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5538811 Sat, 17 Dec 2011 05:00:00 +0100 5538811 http://www.medworm.com/index.php?rid=5538823&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22170229%26dopt%3DAbstract Authors: Yagi T, Ishikawa J, Aono N, Yamashita Y, Kusakabe S, Yoshinami T, Akazawa Y, Sakai D, Yamamoto S, Hamanaka Y, Masaie H, Sugimoto N, Yoshida H, Tomita Y, Imamura F Abstract A 56-year-old woman with Hodgkin-like adult T-cell leukemia/lymphoma was treated with allogeneic peripheral blood stem cell transplantation on 17 April 2009. She manifested a moderate fever on day 41. CT scanning and other examinations detected slightly swollen lymph nodes, and pathological findings of right axillary lymph nodes revealed an Epstein-Barr virus-associated post-transplant lymphoproliferative disorder. She was successfully treated with rituximab. PMID: 22170229 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5538823 Fri, 16 Dec 2011 05:00:00 +0100 5538823 http://www.medworm.com/index.php?rid=5538824&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22170228%26dopt%3DAbstract Authors: Muzaffar J, Katragadda L, Haider S, Javed A, Anaissie E, Usmani S Abstract Acquired factor VIII inhibitor (AFI) is a rare disorder and is even more uncommon in multiple myeloma patients, with only five cases reported in literature. Solid and hematologic malignancies, autoimmune conditions, drugs, and infections are the conditions commonly associated with the development of this condition, with mucocutaneous bleeding being the most common presenting sign. Diagnosis is usually made with the laboratory finding of an elevated partial thromboplastin time aPTT that cannot be corrected by plasma mixing, and further confirmed by low factor VIII activity/antigen levels along with elevated factor VIII inhibitor levels using the Bethesda assay. Treatment is usually based on the clini... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5538824 Thu, 15 Dec 2011 05:00:00 +0100 5538824 http://www.medworm.com/index.php?rid=5538822&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22170230%26dopt%3DAbstract Authors: Munoz J, Hong D, Kurzrock R PMID: 22170230 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5538822 Thu, 15 Dec 2011 05:00:00 +0100 5538822 http://www.medworm.com/index.php?rid=5538832&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22160825%26dopt%3DAbstract Authors: Ngoma AM, Ikeda K, Hashimoto Y, Mochizuki K, Takahashi H, Sano H, Matsumoto H, Noji H, Saito S, Kikuta A, Ogawa K, Ohtsuka M, Abe M, Nollet KE, Ohto H Abstract To elucidate the correlation between regulatory T cells (Tregs) and acute graft-versus-host disease (aGVHD) or cytomegalovirus infection following allogeneic bone marrow transplantation (allo-BMT), we evaluated either CD4(+)CD25(high) or FOXP3(+) Treg-enriched cells in peripheral blood (PB) from 20 patients who received allo-BMT, and in biopsies of skin with aGVHD. Proportions of CD4(+)CD25(high)FOXP3(+) cells in total lymphocytes, but not other types of T cells, were lower in patients who eventually developed grades II-IV aGVHD (n = 13) than in others (n = 7, P < 0.001). Proportions of CD62L(+) cells in CD... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5538832 Wed, 14 Dec 2011 05:00:00 +0100 5538832 http://www.medworm.com/index.php?rid=5538827&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22167655%26dopt%3DAbstract A case of successful management of HHV-8(+), EBV (+) germinotropic lymphoproliferative disorder (GLD). Int J Hematol. 2011 Dec 14; Authors: Oh J, Yoon H, Shin DK, Jang MJ, Kim GI, Chong SY, Oh D Abstract Human herpesvirus 8-positive (HHV-8(+)) and Epstein-Barr virus-positive (EBV(+)) germinotropic lymphoproliferative disorder (GLD) is extremely rare and occurs most commonly in immunocompetent persons who are human immunodeficiency virus (HIV)-seronegative. It is also recognized as a favorable response to conventional chemotherapy. Here, we report a case of a 75-year-old man with an incidentally found mass in the neck, compatible with GLD, which was detected by positron emission tomography (PET). Computed tomography (CT) scan, PET, and bone marrow studies showed only the... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5538827 Wed, 14 Dec 2011 05:00:00 +0100 5538827 http://www.medworm.com/index.php?rid=5538826&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22167656%26dopt%3DAbstract Authors: Fujioka Y, Kurokawa M PMID: 22167656 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5538826 Wed, 14 Dec 2011 05:00:00 +0100 5538826 http://www.medworm.com/index.php?rid=5538825&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22167657%26dopt%3DAbstract Authors: Ebara S, Song SN, Mizuta H, Ito Y, Hasegawa K, Kamata T, Matsumura-Nishikawa T, Ogawa T, Soneda J, Yoshizaki K Abstract Dysregulated overproduction of interleukin-6 (IL-6) from activated B cells in affected lymph nodes has been implicated in the pathogenesis of multicentric Castleman's disease (MCD), a rare lymphoproliferative disorder accompanied by systemic manifestations. We here report the case of a 32-year-old female presenting with MCD associated with a dermoid cyst in the pelvic cavity. The co-occurrence of MCD and dermoid cyst has not been reported before. Immunohistochemical analysis of the tissue sections showed IL-6 production in CD68-positive macrophage cells, which had infiltrated the dermoid cyst. Removal of the cyst resulted in partial improvement in systemi... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5538825 Wed, 14 Dec 2011 05:00:00 +0100 5538825 http://www.medworm.com/index.php?rid=5538831&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22160833%26dopt%3DAbstract Authors: Kaya H, Peressini B, Jawed I, Martincic D, Elaimy AL, Lamoreaux WT, Fairbanks RK, Weeks KA, Lee CM Abstract With the availability of novel agents, the overall survival (OS) in patients diagnosed with multiple myeloma (MM) has improved over the last decade. Data on 40,294 MM patients in the years from 1973 to 2003 were obtained from the Surveillance, Epidemiology, and End Results Program (SEER) of the US National Cancer Institute. Statistical analyses evaluating gender, race, age, and year of diagnosis were performed using univariate and multivariate Cox regression models for the OS endpoint. The mean patient age at diagnosis was 68.3 years. Mean survival was 30 months (median = 19 months). Asian/Pacific Islander race was associated with an improved OS, HR 0.90 (CI 0.8... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5538831 Fri, 09 Dec 2011 05:00:00 +0100 5538831 http://www.medworm.com/index.php?rid=5538830&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22160834%26dopt%3DAbstract Authors: Kobayashi T, Nakabayashi M, Yoshioka A, Maeda M, Ikenoue T Abstract Only a limited number of case reports documenting the off-label use of recombinant factor VIIa (rFVIIa) in Japanese patients with postpartum haemorrhage (PPH) have been published. Data on Japanese cases with severe PPH in which rFVIIa was administered were collected. Data of obstetric haemorrhage patients treated with rFVIIa between 2005 and 2010 were retrospectively collected throughout Japan. The data included patients' background information, blood product requirements, dose/timing of rFVIIa, and adverse effects. Treating clinicians subjectively assessed the effect of rFVIIa on bleeding at each administration using four categories: "Stopped", "Decreased", "Unchanged", and "Increased". A total of 25 wome... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5538830 Fri, 09 Dec 2011 05:00:00 +0100 5538830 http://www.medworm.com/index.php?rid=5538829&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22160835%26dopt%3DAbstract This study was conducted to determine whether body mass index (BMI) and other body composition parameters, such as lean body mass index (LBMI) and body fat mass (BFM), are associated with early post-transplantation toxicity and mortality in allogeneic HSCT recipients. The records of 71 patients diagnosed with acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML), or myelodysplastic leukemia (MDS) who had undergone allogeneic HSCT with a conditioning regimen of busulfan-cyclophosphamide (Bu-Cy), between September 2003 and January 2009 at the Stem Cell Transplantation Unit of Gazi University Hospital were retrospectively evaluated. BMI was found to be negatively correlated with the NCI grade of mucositis, cardiotoxicity, emesis, and hyperglycemia, a... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5538829 Fri, 09 Dec 2011 05:00:00 +0100 5538829 http://www.medworm.com/index.php?rid=5538828&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22160836%26dopt%3DAbstract We present a case of PRES in an adult patient with acute lymphoblastic leukemia (ALL) after remission induction chemotherapy. A 28-year-old woman with ALL was administered remission induction chemotherapy consisting of cyclophosphamide, daunorubicin, vincristine, prednisone, and L: -asparaginase. After initiation of chemotherapy, the patient developed paralytic ileus and hypertension, and on day 30, she suddenly developed generalized convulsions, loss of visual acuity, and muscle weakness in the legs. Magnetic resonance imaging findings and her signs and symptoms were typical of PRES. The symptoms gradually improved following treatment with an anticonvulsant and an antihypertensive agent, and the patient underwent allogeneic bone marrow transplantation. She has completely recovered from PR... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5538828 Fri, 09 Dec 2011 05:00:00 +0100 5538828 http://www.medworm.com/index.php?rid=5479534&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22135078%26dopt%3DAbstract Authors: Tachibana T, Tanaka M, Takasaki H, Numata A, Fujisawa S, Maruta A, Harada H, Mori H, Ishigatsubo Y, Kanamori H PMID: 22135078 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5479534 Fri, 02 Dec 2011 05:00:00 +0100 5479534 http://www.medworm.com/index.php?rid=5479538&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22127557%26dopt%3DAbstract Authors: Perdomo-Arciniegas AM, Vernot JP Abstract Hematopoietic stem cells (HSC) lose their capacity for engraftment during ex vivo cytokine expansion. It has been shown that mesenchymal stem cells (MSC) improve HSC transplantability; however, the molecular mechanisms responsible for this effect have not yet been completely elucidated. This paper reports that expanding HSC in co-culture with MSC enhances a vascular cell adhesion molecule (VCAM-1)-dependent pro-migratory phenotype. MSC did not regulate the HSC expression of CD49d (VCAM-1 counter-receptor molecule), but did decrease the cytokine-induced HSC VCAM-1-mediated pro-adhesive phenotype. Co-culture with MSC reduced the expression of the inactive conformation of lymphocyte function-associated antigen (LFA-1) at the HSC uropo... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5479538 Wed, 30 Nov 2011 05:00:00 +0100 5479538 http://www.medworm.com/index.php?rid=5479537&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22127558%26dopt%3DAbstract Authors: Morita Y, Shimada T, Yamaguchi T, Rai S, Hirase C, Emoto M, Serizawa K, Taniguchi Y, Ojima M, Tatsumi Y, Ashida T, Matsumura I PMID: 22127558 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5479537 Wed, 30 Nov 2011 05:00:00 +0100 5479537 http://www.medworm.com/index.php?rid=5479539&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22116626%26dopt%3DAbstract Authors: Yamamoto G, Maki H, Ichikawa M, Kurokawa M PMID: 22116626 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5479539 Sat, 26 Nov 2011 05:00:00 +0100 5479539 http://www.medworm.com/index.php?rid=5479532&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22139588%26dopt%3DAbstract Authors: Shioda Y, Adachi S, Imashuku S, Kudo K, Imamura T, Morimoto A Abstract To determine the ability of recent systemic chemotherapy protocols to reduce the incidence of central diabetes insipidus (CDI) in Langerhans cell histiocytosis (LCH), 43 CDI cases that belonged to a cohort of 348 pediatric patients with multi-focal LCH who were treated with the JLSG-96/-02 protocols were analyzed. The overall incidence of CDI was 12.4%, but in 24 cases CDI was already present at the time LCH was diagnosed. Thus, CDI developed during or after systemic chemotherapy over a follow-up period of 5.0 (0.2-14.7) years in only 19 patients (5.9%), with 7.4% at 5-year cumulative risk by Kaplan-Meier analysis. In two cases, complete resolution of CDI was noted. Anterior pituitary hormone deficienc... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5479532 Thu, 17 Nov 2011 05:00:00 +0100 5479532 http://www.medworm.com/index.php?rid=5428098&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22086206%26dopt%3DAbstract Authors: Otjacques E, Binsfeld M, Noel A, Beguin Y, Cataldo D, Caers J Abstract Multiple myeloma (MM) is a hematological malignancy characterized by the aberrant expansion of malignant plasma cells within the bone marrow (BM). One of the hallmarks of this disease is the close interaction between myeloma cells and neighboring cells within the BM. Angiogenesis, through the activation of endothelial cells, plays an essential role in MM biology. In the current review, we describe the angiogenesis process in MM by identifying the interacting cells, the pro- and anti-angiogenic cytokines modulated, and the extracellular matrix degrading proteases liable to participate in the pathophysiology. Finally, we highlight the impact of hypoxia (through hypoxia-inducible factor-1) and constitutive... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5428098 Thu, 17 Nov 2011 05:00:00 +0100 5428098 http://www.medworm.com/index.php?rid=5428097&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22090287%26dopt%3DAbstract In this study, we investigated the killing mechanisms of the photosensitizer ZnPcH1 (a mono-α-substituted zinc(II) phthalocyanine synthesized in China), in the acute lymphoid leukemia cell line Jurkat and the acute erythroleukemia cell line HEL. Results from acridine orange/ethidium bromide fluorescence staining, DNA gel electrophoresis, and Annexin-V(FITC/PI) double-stained flow cytometry analysis indicated that ZnPcH1-PDT induced apoptosis in Jurkat and HEL cells, with Jurkat cells being more sensitive. Following ZnPcH1-PDT treatment, upregulation of p53 and Bax, downregulation of HSP70, Bcl-2 and Akt, and inhibition of the phosphorylation of Akt and GSK3β were observed. Our results establish a theoretical basis for the application of ZnPcH1-PDT in the treatment of acute leukemia. ... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5428097 Thu, 17 Nov 2011 05:00:00 +0100 5428097 http://www.medworm.com/index.php?rid=5428099&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22083720%26dopt%3DAbstract Authors: Liptrott SJ, Shash E, Martinelli G Abstract McKee and Schover have suggested that sexuality is an aspect of intimacy that is frequently compromised by cancer and its treatments. Cancer, both in terms of diagnosis and treatments, may have a dramatic impact on both intimacy and sexuality. There is a body of published research addressing sexual concerns among patients with prostatic, testicular, breast, and rectal cancers. This issue seems to be less well documented in patients who have undergone haematopoietic stem cell transplantation (HSCT). In this review, we seek to elaborate different points regarding sexuality and how it is affected in patients undergoing HSCT, with the aim of identifying optimum solutions for such patients in confronting such problems in the course of... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5428099 Tue, 15 Nov 2011 05:00:00 +0100 5428099 http://www.medworm.com/index.php?rid=5428101&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22057509%26dopt%3DAbstract We describe the case of a 37-year-old woman who had CML and pain in the extremities. She was diagnosed with lymphoid blast crisis of CML on the basis of the following findings: presence of promyelocytes, myelocytes, and metamyelocytes in peripheral blood smear; detection of major and minor BCR/ABL transcripts by polymerase chain reaction analysis; proliferation of lymphoblastic cells with abnormal B-cell phenotype; and aberrant expression of myeloid antigens in the bone marrow. The patient underwent one course of idarubicin and cytosine arabinose therapy combined with imatinib followed by daunorubicin/cyclophosphamide plus vincristine and prednisone/L: -asparaginase (DNR/COP/L: -ASP) therapy, high-dose cytosine arabinose, and CHOP therapy (cyclophosphamide, doxorubicin, vincristine, and pr... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5428101 Tue, 08 Nov 2011 05:00:00 +0100 5428101 http://www.medworm.com/index.php?rid=5428100&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22057510%26dopt%3DAbstract We report six cases, four of which developed significant problems with severe hyperlipidaemia during induction therapy for ALL and lymphoblastic lymphoma. The median triglyceride level was 22.3 mmol/L and the median cholesterol level was 12.3 mmol/L. None of the patients showed signs or symptoms of pancreatitis. Three children were re-exposed with Peg asparaginase, and one with Erwinia asparaginase, without recurrence of hyperlipidaemia or other symptoms. These cases highlight the dilemma in managing such rare cases of symptomatic hypertriglyceridaemia secondary to asparaginase and steroid therapy. PMID: 22057510 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5428100 Tue, 08 Nov 2011 05:00:00 +0100 5428100 http://www.medworm.com/index.php?rid=5428102&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22057433%26dopt%3DAbstract Authors: Wu Z, Zhou J, Pankaj P, Peng B Abstract Laparoscopic splenectomy (LS) has become the gold-standard surgical intervention for the treatment of immune thrombocytopenia (ITP) and the patients who experienced medical relapse to steroid. Fewer series are available regarding LS for patients with an extremely low platelet count. The aim of this study is to investigate the feasibility and safety of laparoscopic splenectomy in the treatment of patients with a preoperative platelet count of less than 1 × 109/L. From April 2006 to Jan 2011, 10 patients were managed by laparoscopic splenectomy for idiopathic thrombocytopenia with an extremely low preoperative platelet count. Preoperative, perioperative, and postoperative medical management has been reviewed. Before laparoscopic spl... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5428102 Sat, 05 Nov 2011 04:00:00 +0100 5428102 http://www.medworm.com/index.php?rid=5383371&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22045305%26dopt%3DAbstract Authors: Ganeshan P, Gupta R, Hakim M, Kumar L, Bhaskar A, Sharma A PMID: 22045305 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5383371 Thu, 03 Nov 2011 04:00:00 +0100 5383371 http://www.medworm.com/index.php?rid=5383370&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22045306%26dopt%3DAbstract In this report, we present the case of a 71-year-old male with IVLBCL who showed hypercalcemia accompanied by elevation of serum parathyroid hormone-related protein (PTH-rP) as the initial presentation. Interestingly, immunohistochemical staining revealed that the intravascular lymphoma cells expressed high levels of PTHrP. Six courses of immunochemotherapy, consisting of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP), and two courses of high-dose methotrexate induced complete remission (CR) and retained CR for 4 months. We also reviewed other IVBCL cases in which hypercalcemia was the initial presentation. We suggest that IVLBCL, although rare, should be considered as a possible causative in hypercalcemia of unknown underlying disease. PMID: 22045306... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5383370 Thu, 03 Nov 2011 04:00:00 +0100 5383370 http://www.medworm.com/index.php?rid=5383369&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22045307%26dopt%3DAbstract Authors: Munoz J, Ferrari N, Kuriakose P PMID: 22045307 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5383369 Thu, 03 Nov 2011 04:00:00 +0100 5383369 http://www.medworm.com/index.php?rid=5383373&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22038068%26dopt%3DAbstract Authors: Cao L, Wallace WD, Eshaghian S, Linhares Y, Marder VJ Abstract Hemophagocytic lymphohistiocytosis (HLH) is a heterogeneous disorder characterized by excessive activation and proliferation of nonmalignant histiocytes, which are commonly found in bone marrow, lymph nodes, spleen and liver in affected patients. Here, we report the presence of glomerular macrophages, including one showing erythrophagocytosis, on renal biopsy in a 25-year-old patient with clinical presentation and laboratory changes consistent with HLH. The clinical course was marked by persistent fever for 2 months, pleural and pericardial effusion, splenomegaly, lymphadenopathy, pancytopenia, cardiac arrhythmias, multiple organ dysfunction, and proteinuria, with demise after a 2-month hospitalization. Positi... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5383373 Tue, 01 Nov 2011 04:00:00 +0100 5383373 http://www.medworm.com/index.php?rid=5383372&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22042561%26dopt%3DAbstract Authors: Shigematsu A, Tanaka J, Suzuki R, Atsuta Y, Kawase T, Ito YM, Yamashita T, Fukuda T, Kumano K, Iwato K, Yoshiba F, Kanamori H, Kobayashi N, Fukuhara T, Morishima Y, Imamura M Abstract The choice of conditioning regimen before allogeneic stem cell transplantation (SCT) in patients with acute lymphoblastic leukemia (ALL) is important. We retrospectively compared outcomes of medium-dose VP-16/cyclophosphamide/total body irradiation (VP/CY/TBI) regimen and CY/TBI. Five hundred and twenty-nine patients (VP/CY/TBI: n = 35, CY/TBI: n = 494) who met all of the following criteria were compared: first time for SCT, aged 15-59 years; first or second complete remission at SCT; bone marrow or peripheral blood as stem cell source; and HLA phenotypically matched donor. Median age of... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5383372 Tue, 01 Nov 2011 04:00:00 +0100 5383372 http://www.medworm.com/index.php?rid=5383376&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22038014%26dopt%3DAbstract Authors: Scaramucci L, Tendas A, Niscola P, Bondanini F, Giovannini M, Palombi M, Cupelli L, Efficace F, Perrotti A, de Fabritiis P PMID: 22038014 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5383376 Sat, 29 Oct 2011 04:00:00 +0100 5383376 http://www.medworm.com/index.php?rid=5383375&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22038015%26dopt%3DAbstract Authors: Shimizu H, Saitoh T, Koya H, Yuzuriha A, Hoshino T, Hatsumi N, Takada S, Nagaki T, Nojima Y, Sakura T Abstract Post-transplant lymphoproliferative disorder (PTLD) is a fatal complication of allogeneic hematopoietic stem cell transplantation (HSCT) that is caused by reactivation of Epstein-Barr virus (EBV). A successful approach, monitoring EBV-DNA load in peripheral blood (PB) accompanied by preemptive rituximab therapy, has recently been reported. Here, we describe a 29-year-old woman who developed isolated central nervous system (CNS) PTLD. She received HSCT against acute myelogenous leukemia from a related human leukocyte antigen-haploidentical donor, following a conditioning regimen that included antithymocyte globulin. Tacrolimus and methylprednisolone were given as p... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5383375 Sat, 29 Oct 2011 04:00:00 +0100 5383375 http://www.medworm.com/index.php?rid=5383374&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22038016%26dopt%3DAbstract Authors: Li Y, Yin S, Nie D, Xie S, Ma L, Wang X, Wu Y, Xiao J Abstract Microsomal prostaglandin E synthase-1 (mPGES-1), an inducible enzyme that specifically catalyzes the conversion of prostaglandin H2 (PGH2) to prostaglandin E2 (PGE2), has been reported to be over-expressed in a variety of solid tumor cells and tissues, but not in normal tissues. Its association with leukemia, however, has not been fully investigated. Our study revealed, for the first time, that mPGES-1 is over-expressed in human acute myeloid leukemia HL-60 cells. Cytotoxicity assays and flow cytometry showed that MK886, an inhibitor of mPGES-1, inhibits proliferation of HL-60 cells and induces apoptosis in a dose- and time-dependent manner, which may result from down-regulation of mPGES-1 expression and PGE2 s... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5383374 Sat, 29 Oct 2011 04:00:00 +0100 5383374 http://www.medworm.com/index.php?rid=5383377&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22038013%26dopt%3DAbstract Authors: Au WY, Loong F, Wan TS, Tong AC PMID: 22038013 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5383377 Thu, 27 Oct 2011 04:00:00 +0100 5383377 http://www.medworm.com/index.php?rid=5383378&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22020400%26dopt%3DAbstract We report successful treatment of uterine mast cell sarcoma with imatinib in a 39-year-old woman who presented with abdominal distention and massive ascites. Routine treatment, such as combined chemotherapy, had little effect. We administered imatinib to the patient and achieved a good response in the absence of c-kit mutation, BCR/ABL, and FIP1L1-PDGFRα. Our results indicate that imatinib is of potential use in the treatment of mast cell sarcoma. PMID: 22020400 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5383378 Sat, 22 Oct 2011 04:00:00 +0100 5383378 http://www.medworm.com/index.php?rid=5383382&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22015491%26dopt%3DAbstract We report two patients with chronic granulomatous disease (CGD). The first patient presented with granulomatous colitis and pulmonary aspergillosis, and the second patient with liver abscess and restrictive pulmonary disorder. Both patients underwent allogeneic hematopoietic stem cell transplantation, the first from an HLA-matched sibling donor, and the second from an HLA-matched unrelated donor, after preconditioning with fludarabine, anti-thymocyte globulin, cyclophosphamide, and total-body irradiation of 3 Gy. The engraftment was prompt and the regimen-related toxicity was mild. The patients are able to return to their daily lives with full donor chimerism, although the second patient underwent a living-related-donor orthotopic liver transplantation from his mother for chronic liver gr... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5383382 Fri, 21 Oct 2011 04:00:00 +0100 5383382 http://www.medworm.com/index.php?rid=5383381&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22015492%26dopt%3DAbstract Authors: Okur M, Ozkan A, Gunes C, Kaya M, Kocabay K Abstract The most common form of isolated thrombocytopenia is idiopathic thrombocytopenic purpura (ITP) in childhood. Hence, pediatricians consider a possible diagnosis of ITP in patients with isolated thrombocytopenia who are admitted to hospital with complaints of skin findings such as petechiae, purpura, and ecchymosis. It is well known that cobalamin deficiency may also cause thrombocytopenia together with anemia and leukopenia in children. However, isolated thrombocytopenia due to cobalamin deficiency has rarely been reported in literature. In this case report, we present a 7-year-old female patient with isolated thrombocytopenia that was improved by cyanocobalamin therapy. PMID: 22015492 [PubMed - as supplied by publish... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5383381 Fri, 21 Oct 2011 04:00:00 +0100 5383381 http://www.medworm.com/index.php?rid=5383380&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22015493%26dopt%3DAbstract In this report, we review 21 adult patients with Ph-positive and/or bcr-abl positive MPAL. They were predominantly male, and presented with high WBC counts; 61.9% patients had WBC counts higher than 30 × 10(9)/L, and 33.3% patients had WBC counts higher than 100 × 10(9)/L. Electron microscopy (EM)-determined positivity for myeloperoxidase (MPO) should be considered for the classification of acute leukemia because MPO was positive by EM and flow cytometry only in 14.3% of cases in our study. Six cases (30.0%) had additional chromosome aberrations. Expression of p190( bcr-abl ) was more common than that of p210( bcr-abl ). There was no difference in characteristics between the p190( bcr-abl ) positive and p210( ... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5383380 Fri, 21 Oct 2011 04:00:00 +0100 5383380 http://www.medworm.com/index.php?rid=5383379&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22015494%26dopt%3DAbstract We report four cases of adult-onset Langerhans cell histiocytosis (LCH) with central nervous system (CNS) lesions in the hypothalamic-pituitary region. The first clinical symptoms were diabetes insipidus (two patients), hypothyroidism (one patient), and decreased libido/erectile dysfunction (one patient). Diagnosis was delayed as the CNS lesion was not initially suspected to be secondary to LCH, with a median time from symptom onset to treatment of 3.0 (range <1-5.3) years. In three patients, the tumor mass was effectively reduced by chemotherapy; however, all patients continue to exhibit hypopituitarism. Early diagnosis and initiation of treatment are required to improve the outcome of CNS-LCH in adult patients. PMID: 22015494 [PubMed - as supplied by publisher] (Source: Internatio... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5383379 Fri, 21 Oct 2011 04:00:00 +0100 5383379 http://www.medworm.com/index.php?rid=5383385&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21993873%26dopt%3DAbstract Authors: Porter JB, Evangeli M, El-Beshlawy A Abstract Due to advances in medical sciences, many chronic diseases that formerly resulted in early death can now be effectively managed with long-term treatment regimens. Patients with potentially fatal anemias, for example, can be treated with ongoing blood transfusions and iron chelation therapy. Ensuring adherence and persistence is challenging, as the benefits of therapy are not perceived immediately. Poor adherence severely compromises the effectiveness of treatment and, therefore, improving compliance in terms of quality of life and health economics is critical. Although adherence to chelation therapy is generally poor, the availability of oral iron chelators may help to improve patient compliance. For chronic conditions such as ... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5383385 Thu, 13 Oct 2011 04:00:00 +0100 5383385 http://www.medworm.com/index.php?rid=5383384&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21993874%26dopt%3DAbstract Authors: Ishida T, Ueda R Abstract Adult T-cell leukemia-lymphoma (ATL) has a very poor prognosis. Since there currently are limited treatment options for ATL patients, several novel agents are being developed and tested clinically. Antibody therapy against ATL was initially started with interleukin-2 receptor α-subunit, CD25, as a target molecule in the late 1980s, and is currently ongoing. CC chemokine receptor 4 (CCR4) was postulated as a novel molecular target in ATL antibody therapy, and humanized anti-CCR4 mAb (KW-0761), whose Fc region was defucosylated to enhance antibody-dependent cellular cytotoxicity, was developed. A phase I study of KW-0761 in relapsed ATL and peripheral T-cell lymphoma was started in 2006, and a subsequent phase II study was completed in 2010. KW-076... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5383384 Thu, 13 Oct 2011 04:00:00 +0100 5383384 http://www.medworm.com/index.php?rid=5383383&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21993875%26dopt%3DAbstract Authors: Marino D, Farina P, Jirillo A, De Franchis G, Simonetto M, Aversa SM Abstract A 63-year-old man was admitted to our Oncology department for management of a follicular non-Hodgkin lymphoma, stage IV A FLIPI 5. The patient entered chemotherapy following the R-CHOP schedule, and a PET scan after three cycles showed partial remission. One week later he was admitted to our hospital after developing serious pain in his left arm resulting in an impaired function, right facial hemiplegia, and ophthalmoplegia. Neuroimaging studies and laboratory features were negative. Given his symptoms, we suspected Miller Fisher syndrome and the patient was administered high dose immunoglobulin, but showed no improvement. Finally, chemotherapy with methotrexate 3 g/mq was initiated, but his con... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5383383 Thu, 13 Oct 2011 04:00:00 +0100 5383383 http://www.medworm.com/index.php?rid=5284202&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21969187%26dopt%3DAbstract Authors: Watanabe T Abstract It is 30 years since human T-cell leukemia virus type 1 (HTLV-1) was identified as the first human retrovirus. To assess the implications of the virus for human health it is very important to know the past and present prevalence. Most of the estimates of HTLV-1 prevalence are based on serological screening of blood donors, pregnant women and other selected population groups. The widely cited estimate that the number of HTLV-1 carriers in Japan is 1.2 million was calculated from data that are now more than 25 years old. Here I summarize previous reports of prevalence studies in the world and Japan. Then, a recent analysis of seroprevalence of healthy blood donors in Japan will be described in comparison with that of 1988. A decrease in the number of HT... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5284202 Tue, 04 Oct 2011 04:00:00 +0100 5284202 http://www.medworm.com/index.php?rid=5284201&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21969188%26dopt%3DAbstract Authors: Matsuoka M PMID: 21969188 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5284201 Tue, 04 Oct 2011 04:00:00 +0100 5284201 http://www.medworm.com/index.php?rid=5284204&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21960057%26dopt%3DAbstract Authors: Fukushima T, Taguchi J, Moriuchi Y, Yoshida S, Itonaga H, Ando K, Sawayama Y, Imaizumi Y, Imanishi D, Hata T, Miyazaki Y Abstract Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is regarded as a curative option for aggressive adult T cell leukemia-lymphoma (ATL). However, the efficacy and safety of allo-HSCT for ATL with central nervous system (CNS) involvement, which is highly resistant to chemotherapy, remain controversial. We analyzed 10 ATL patients with CNS involvement who received allo-HSCT at three institutions in Nagasaki prefecture between 2000 and 2007. The 3-year overall survival rate was 40%, and the median observation time of the four surviving patients was 1532 days (range 945-2212 days). Two of four surviving patients received highly intensi... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5284204 Fri, 30 Sep 2011 04:00:00 +0100 5284204 http://www.medworm.com/index.php?rid=5284203&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21960058%26dopt%3DAbstract Authors: Shigekiyo T, Sekimoto E, Shirakami A, Yamaguchi H, Shibata H, Ozaki S, Kanda K, Saito S, Satake N, Fujino O PMID: 21960058 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5284203 Fri, 30 Sep 2011 04:00:00 +0100 5284203 http://www.medworm.com/index.php?rid=5284205&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21956663%26dopt%3DAbstract Authors: Nishi Y, Hamamoto K, Fujita N, Okada S Abstract Radiation-induced empty sella (ES) or pituitary atrophy/small pituitary and endocrine impairments, including pituitary and gonadal dysfunction, can manifest decades after radiation and chemotherapy in childhood-onset leukemia patients who received prophylactic cranial irradiation or total body irradiation in preparation for bone marrow transplant. Six childhood-onset leukemia patients (age at diagnosis of leukemia; 2.7-10.2 years) participated in this study. Magnetic resonance imaging (MRI) of the pituitary gland and endocrinological studies were performed 10.5-32.1 years after cranial irradiation. In four of the six patients examined, ES or pituitary atrophy was detected approximately 10.5-19.8 years after cranial irradia... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5284205 Thu, 29 Sep 2011 04:00:00 +0100 5284205 http://www.medworm.com/index.php?rid=5284207&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21953272%26dopt%3DAbstract Authors: Ljung R, Oldenburg J, Auerswald G, van den Berg M, Shima M, Dimichele D PMID: 21953272 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5284207 Wed, 28 Sep 2011 04:00:00 +0100 5284207 http://www.medworm.com/index.php?rid=5284206&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21953273%26dopt%3DAbstract Authors: Yasunaga J, Matsuoka M Abstract Human T cell leukemia virus type 1 (HTLV-1) is an etiological pathogen of several human diseases, including adult T-cell leukemia (ATL), HTLV-1-associated myelopathy (HAM)/tropical spastic paraparesis (TSP), and inflammatory disorders such as uveitis and dermatitis. HTLV-1 spreads mainly through cell-to-cell transmission, induces clonal proliferation of infected T cells in vivo, and after a long latent period, a subset of HTLV-1 carriers develop ATL. Understanding the molecular mechanisms of infection and oncogenesis is important for the development of new strategies of prophylaxis and molecular-targeted therapies, since ATL has a poor prognosis, despite intensive chemotherapy. In this review, we will summarize recent progress in HTLV-1 rese... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5284206 Wed, 28 Sep 2011 04:00:00 +0100 5284206 http://www.medworm.com/index.php?rid=5284209&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21948263%26dopt%3DAbstract Authors: Tharmalingam H, Ashby DR, Busbridge M, Roufosse C, Cairns TD PMID: 21948263 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5284209 Fri, 23 Sep 2011 04:00:00 +0100 5284209 http://www.medworm.com/index.php?rid=5284208&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21948264%26dopt%3DAbstract Authors: Takagi K, Kawai Y, Yamauchi T, Iwasaki H, Ueda T Abstract Overcoming drug resistance remains a major obstacle to curing relapsed or refractory lymphoma and obtaining a beneficial long-term prognosis for patients, despite the introduction of several salvage regimens to date. Our ultimate purpose is to establish a standard second-line salvage chemotherapy regimen for curing relapsed/refractory lymphoma. In this basic pre-clinical study, we evaluated a combination regimen consisting of 9-β-D: -arabinofuranosyl-2-fluoroadenine (F-araA) and carboplatin that targeted nucleotide excision repair (NER) of DNA in five representative leukemia lineages in vitro. Isobologram analysis demonstrated that simultaneous exposure to these two drugs produced synergistic interactions in U937 a... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5284208 Fri, 23 Sep 2011 04:00:00 +0100 5284208 http://www.medworm.com/index.php?rid=5249667&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21935756%26dopt%3DAbstract In conclusion, 1.5 mg of Fondaparinux may not be sufficient for the prophylaxis of silent DVT, but it was found to be useful for that of fatal pulmonary embolism. Consequently, monitoring anti-Xa activity may be unnecessary for the administration of Fondaparinux at such doses. PMID: 21935756 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5249667 Thu, 22 Sep 2011 04:00:00 +0100 5249667 http://www.medworm.com/index.php?rid=5235156&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21927799%26dopt%3DAbstract Authors: Taniguchi K, Okada M, Yoshihara S, Sawada A, Tokugawa T, Ishii S, Kaida K, Ikegame K, Minagawa K, Matsui T, Ogawa H Abstract Although the recent introduction of eculizumab has had a significant impact on the management of paroxysmal nocturnal hemoglobinuria (PNH), bone marrow transplantation (BMT) remains the only therapeutic option for patients who develop severe aplasia in the clinical course of PNH. However, information regarding BMT for eculizumab-treated PNH patients is scarce, and two major points-the optimal duration of eculizumab therapy, and the optimal BMT conditioning regimen-remain unclear. Here, we describe the clinical course of a PNH patient who was successfully treated with unrelated reduced-intensity BMT. Eculizumab was discontinued 2 weeks prior to the i... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5235156 Sat, 17 Sep 2011 04:00:00 +0100 5235156 http://www.medworm.com/index.php?rid=5235155&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21927800%26dopt%3DAbstract We report a patient with APL carrying a new complex variant translocation (5;17;15;20). Spectral karyotyping analysis of bone marrow cells revealed t(5;17;15;20)(q33;q12;q22;q11.2). Fluorescence in situ hybridization with a PML/RARA dual-color DNA probe showed a single fusion signal, and RT-PCR analysis showed PML/RARA fusion transcripts. Complete remission was attained with a course of conventional chemotherapy with all-trans retinoic acid (ATRA). To our knowledge, this is the first report of a four-way translocation of 5q33 and 20q11 involvement in APL. PMID: 21927800 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5235155 Sat, 17 Sep 2011 04:00:00 +0100 5235155 http://www.medworm.com/index.php?rid=5221614&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21904952%26dopt%3DAbstract Authors: Hatakeyama N, Hori T, Yamamoto M, Mizue N, Inazawa N, Igarashi K, Tsutsumi H, Suzuki N Abstract Long-term venous access is essential when treating malignant diseases. We reviewed our experience with peripherally inserted central venous catheters (PICC) in children suffering from various malignancies with regard to catheter life, reasons for removal, and complications. Ninety-three PICCs were inserted in 78 children. Median catheter life was 162 days (range 6-575 days) with a total of 16,266 catheter days. Seventy-five PICCs (80.6%) had been placed until the elective removal or patients' death, whereas 18 PICCs (19.4%) were removed due to PICC-related complications; a rate of 1.11 per 1,000 catheter days. Complications requiring removal of PICCs included infection (n = ... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5221614 Fri, 09 Sep 2011 04:00:00 +0100 5221614 http://www.medworm.com/index.php?rid=5221615&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21901399%26dopt%3DAbstract Authors: Kim D, Goh HG, Kim SH, Cho BS, Kim DW Abstract Dasatinib is a potent second-generation tyrosine kinase inhibitor approved for the treatment of chronic myeloid leukemia after imatinib failure. However, some patients treated with dasatinib experience pleural effusions (PEs). The determinants of pleural effusion in long-term dasatinib treatment (median 35 months, range 1-55) were investigated in single-center data of 65 patients enrolled in global phase 2 and phase 3 trials. Of the 65 patients, 35 (54%) developed dasatinib-induced pleural effusion (a median onset time, 20 months; range 0.2-54). The first pleural effusion developed in 15 (43%) patients within 12 months of dasatinib therapy. Disease phase (P = 0.02), dose schedule (P = 0.002) and actual daily mean dose (... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5221615 Thu, 08 Sep 2011 04:00:00 +0100 5221615 http://www.medworm.com/index.php?rid=5221619&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21881879%26dopt%3DAbstract Authors: Hideshima T, Anderson KC Abstract During the last decade, thalidomide, lenalidomide, and bortezomib have been approved by the US Food and Drug Administration for the treatment of MM; however, MM remains incurable. The development and progression of multiple myeloma (MM) is a complex multi-step process involving genetic abnormalities in tumor cells at both early and late stages. Moreover, soluble factors and cell-cell contact within the tumor bone marrow (BM) microenvironment promotes MM cell growth, survival, and drug resistance. A number of novel agents targeting both tumor cells and growth factors in the BM milieu have been developed. Currently they are under evaluation in preclinical studies, as single agents and/or in combination, to improve outcome of MM patients. ... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5221619 Thu, 01 Sep 2011 04:00:00 +0100 5221619 http://www.medworm.com/index.php?rid=5221618&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21898174%26dopt%3DAbstract Authors: Medd P, Monk I, Danby R, Malladi R, Clifford R, Ellis A, Roberts D, Hatton C, Vyas P, Littlewood T, Peniket A Abstract We investigated the contributions of methotrexate (MTX) and ciclosporin (CsA) prophylaxis to acute/chronic graft-versus-host disease (a/cGvHD) prevention following reduced-intensity conditioned allogeneic haematopoietic stem cell transplant (HSCT). Ninety-two fludarabine-melphalan sibling allo-SCT received CsA. Nine, 30 and 47 patients received no MTX, 2-3 doses and 4 doses, respectively. Cumulative CsA blood level to day 21 (CsA(21)) was calculated. Grades II-IV aGvHD incidence was 37.2%. In multivariate analysis, MTX omission and increasing donor age significantly associated with aGvHD incidence whilst MTX reduction and CsA(21) did not. Median duration o... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5221618 Thu, 01 Sep 2011 04:00:00 +0100 5221618 http://www.medworm.com/index.php?rid=5221617&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21901397%26dopt%3DAbstract Authors: Razga F, Racil Z, Machova Polakova K, Buresova L, Klamova H, Zackova D, Dvorakova D, Polivkova V, Cetkovsky P, Mayer J PMID: 21901397 [PubMed - in process] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5221617 Thu, 01 Sep 2011 04:00:00 +0100 5221617 http://www.medworm.com/index.php?rid=5221616&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21901398%26dopt%3DAbstract Authors: Hua Z, Chun W, Fang-Yuan C Abstract MicroRNAs (MiRNAs) are a class of small non-coding regulatory RNAs that repress protein expression at the posttranscriptional level and play important roles in hematopoiesis processes. MiR-146a is a miRNA that is thought to regulate physiological and pathophysiological pathways in hematopoietic cells. In this review, we focus on recent progress in analyzing the functional roles of miR-146a in normal hematopoiesis and hematopoietic disease. We suggest that manipulation of miR-146a expression may represent a potential new therapy for several hematopoietic diseases, and may further serve as a biomarker for diagnosis, prevention, and treatment of such disease. PMID: 21901398 [PubMed - in process] (Source: International Journal of Hematol... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5221616 Thu, 01 Sep 2011 04:00:00 +0100 5221616 http://www.medworm.com/index.php?rid=5180395&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21879292%26dopt%3DAbstract Authors: Arita K, Kondo T, Sugita J, Shigematsu A, Shiratori S, Wakasa K, Yasumoto A, Ibata M, Shono Y, Kikuchi M, Goto H, Takeda Y, Takahata M, Kato N, Nishio M, Ota S, Tanaka J, Imamura M Abstract The prognosis of patients receiving allogeneic hematopoietic stem cell transplantation (HSCT) for refractory acute lymphoblastic leukemia (ALL) is very poor. To improve survival rates, we attempted to intensify the conditioning regimen with daunorubicin, vincristine, prednisolone, medium-dose etoposide, cyclophosphamide, and total body irradiation (DNR/VCR/PSL plus medium-dose VP/CY/TBI). Four patients in relapse or induction failure of B-precursor ALL without other complications underwent allogeneic HSCT. Initially, chemotherapy comprising DNR 60 mg/m(2) for 3 days, VCR 1.4 mg/m(2) ... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5180395 Tue, 30 Aug 2011 23:00:00 +0100 5180395 http://www.medworm.com/index.php?rid=5180397&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21877111%26dopt%3DAbstract Authors: Kadono M, Kakihana K, Endo I, Kawamura M, Ohashi K, Sakamaki H PMID: 21877111 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5180397 Mon, 29 Aug 2011 23:00:00 +0100 5180397 http://www.medworm.com/index.php?rid=5180396&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21877112%26dopt%3DAbstract Authors: Oshima Y, Tojo A PMID: 21877112 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5180396 Mon, 29 Aug 2011 23:00:00 +0100 5180396 http://www.medworm.com/index.php?rid=5160376&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21863285%26dopt%3DAbstract Authors: Tanimura A, Yujiri T, Tanaka Y, Tanaka M, Mitani N, Nakamura Y, Ariyoshi K, Tanizawa Y PMID: 21863285 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5160376 Tue, 23 Aug 2011 23:00:00 +0100 5160376 http://www.medworm.com/index.php?rid=5160375&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21863286%26dopt%3DAbstract We present a case of a 3-month-old girl with Munc13-4 mutation (FHL3), who underwent bone marrow transplantation (BMT) from her human leukocyte antigen-haploidentical mother following reduced intensity conditioning (RIC) with fludarabine, melphalan, and busulfan. Engraftment after BMT was generally uneventful, with only mild acute graft versus host disease. Munc13-4 protein was restored following BMT, and she is well and free of disease 14 months after BMT. These results suggest that BMT with RIC from a family haploidentical donor may sufficiently restore immune regulation in infants, while lessening treatment-related mortality and long-term sequelae. PMID: 21863286 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5160375 Tue, 23 Aug 2011 23:00:00 +0100 5160375 http://www.medworm.com/index.php?rid=5160374&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21863287%26dopt%3DAbstract Authors: Inokuchi K, Wakita S, Hirakawa T, Tamai H, Yokose N, Yamaguchi H, Dan K Abstract Recently, RCSD1 was identified as a novel gene fusion partner of the ABL1 gene. The RCSD1 gene, located at 1q23, is involved in t(1;9)(q23;q34) translocation in acute B lymphoblastic leukemia. Here we describe RCSD1-ABL1-positive B-cell acute lymphoblastic leukemia (ALL) followed by rapid clonal evolution exhibiting three rare reciprocal translocations. We performed breakpoint analysis of the transcript expressed by the RCSD1-ABL1 fusion gene. RT-PCR and sequence analyses detected transcription of a single RCSD1-ABL1 fusion gene variant, which had breakpoints in exon 3 of RCSD1 and exon 4 of ABL1. The RCSD1 portion of the RCSD1-ABL1 fusion transcript consists of exons 1, 2, and 3. Tyrosine kin... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5160374 Tue, 23 Aug 2011 23:00:00 +0100 5160374 http://www.medworm.com/index.php?rid=5160377&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21861100%26dopt%3DAbstract Authors: Tanaka T, Yamasaki R, Omura H, Hino N PMID: 21861100 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5160377 Mon, 22 Aug 2011 23:00:00 +0100 5160377 http://www.medworm.com/index.php?rid=5160383&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21858442%26dopt%3DAbstract Authors: Oshima Y, Tojo A PMID: 21858442 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5160383 Fri, 19 Aug 2011 23:00:00 +0100 5160383 http://www.medworm.com/index.php?rid=5160382&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21858443%26dopt%3DAbstract Authors: Hanoun M, Röth A, Dührsen U, Brock FE PMID: 21858443 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5160382 Fri, 19 Aug 2011 23:00:00 +0100 5160382 http://www.medworm.com/index.php?rid=5160381&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21858444%26dopt%3DAbstract Authors: Nakazato T, Suzuki K, Mihara A, Sanada Y, Aisa Y, Kakimoto T, Moriyama M PMID: 21858444 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5160381 Fri, 19 Aug 2011 23:00:00 +0100 5160381 http://www.medworm.com/index.php?rid=5160380&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21858445%26dopt%3DAbstract Authors: Chen X, Chen S, Li C, Zhu Y, Peng B Abstract T-cell abnormalities are considered important in the pathogenesis of immune thrombocytopenia (ITP). Th1 polarization of the immune response in peripheral blood mononuclear cells (PBMC) has been observed in ITP patients. However, whether the polarization of T-cell subsets exists in splenocytes remains unclear. In the present study, we detected T-cell subsets and macrophage phagocytosis capacity in the spleens of ten ITP patients failing first-line treatment. Compared with traumatic patients, ITP patients had similar percentages of Th1, Tc1, and T1 (Th1 + Tc1) cells, but lower percentages of Th2 and Tc2 cells, which did not, however, reach significant difference. ITP patients had significantly lower percentages of T2 (Th2 + Tc... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5160380 Fri, 19 Aug 2011 23:00:00 +0100 5160380 http://www.medworm.com/index.php?rid=5160379&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21858446%26dopt%3DAbstract Authors: Michishita Y, Hirokawa M, Guo YM, Abe Y, Liu J, Ubukawa K, Fujishima N, Fujishima M, Yoshioka T, Kameoka Y, Saito H, Tagawa H, Takahashi N, Sawada K Abstract It has been suggested that γδ T cells are involved in certain autoimmune disorders. To establish reference data for clinical studies to explore the role of γδ T cells in autoimmune bone marrow failure syndrome, we examined the γδ T-cell repertoire in 120 healthy Japanese individuals by flow cytometry. The average numbers of T lymphocytes in blood were as follows: 1,084 ± 369 (SD) αβ T cells, 68 ± 44 γδ T cells, 16 ± 12 Vδ1 T cells, and 43 ± 36 Vδ2 T cells (/μl). Absolute numbers of γδ T cells decreased with aging (R = -0.378, P < 0.001). The decrease of γδ T cells was the result o... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5160379 Fri, 19 Aug 2011 23:00:00 +0100 5160379 http://www.medworm.com/index.php?rid=5160378&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21858447%26dopt%3DAbstract Authors: Terasaki Y, Yamamoto H, Kiyokawa H, Okumura H, Saito K, Ichinohasama R, Ishida Y Abstract Primary effusion lymphoma (PEL) is a rare type of non-Hodgkin lymphoma usually confined to the body cavities of predominantly immunosuppressed patients infected with human herpes virus-8 (HHV-8). In PEL, malignant cells are usually negative for B-cell markers, such as CD19, CD20, and CD79a, but are positive for activation and plasma cell-related markers, such as CD30, CD38, and CD138. It has been reported that HHV-8-unrelated PEL shows high expression of B-cell markers, which is referred to as PEL-like lymphoma. Here, we report two cases of HHV-8-unrelated HIV-negative PEL-like lymphoma in which malignant cells regressed spontaneously after effusion drainage alone. These cells express... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5160378 Fri, 19 Aug 2011 23:00:00 +0100 5160378 http://www.medworm.com/index.php?rid=5142827&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21853271%26dopt%3DAbstract This study aimed to evaluate whether addition of eye rinse, which was designed to remove cytarabine from ocular surface, further reduces the incidence of kerato-conjunctivitis in the same setting. Seventy-six patients receiving cytarabine at a dose of 3 g/m(2) every 12 h for 4 days after receiving TBI (12 Gy) as conditioning for HSCT were evaluated. All patients received betamethasone sodium phosphate eye drops. Twenty-three patients were further instructed to rinse their eyes with sterile saline every 10-15 min during and for two additional hours after the completion of each cytarabine infusion. Among 23 patients with eye rinse, Grades 2-3 and 1-3 kerato-conjunctivitis were observed in 4 (17.4%) and 5 patients (21.7%), respectively. These incidences were significantly lower than thos... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5142827 Thu, 18 Aug 2011 23:00:00 +0100 5142827 http://www.medworm.com/index.php?rid=5112145&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21823042%26dopt%3DAbstract Authors: Shima Y, Kitabayashi I Specific chromosomal translocations and other mutations associated with acute myeloblastic leukemia (AML) often involve transcription factors and transcriptional coactivators. Such target genes include AML1, C/EBPα, RARα, MOZ, p300/CBP, and MLL, all of which are important in the regulation of hematopoiesis. The resultant fusion or mutant proteins deregulate the transcription of the affected genes and disrupt their essential role in hematopoiesis, causing differentiation block and abnormal proliferation and/or survival. This review focuses on such transcription factors and coactivators, and describes their roles in leukemogenesis and hematopoiesis. PMID: 21823042 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5112145 Mon, 08 Aug 2011 23:00:00 +0100 5112145 http://www.medworm.com/index.php?rid=5112147&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21822587%26dopt%3DAbstract Authors: Jiang M, Zhao Y, Shen F, Wang F, He Y, Ruan C von Willebrand factor (VWF) serves as a molecular bridge between the constituents of the subendothelium, such as collagen, and receptors of the platelet membrane, primarily GPIb. We have previously reported two monoclonal antibodies (mAbs), SZ-123 and SZ-125, which specifically bind the VWF A3 domain and block the interaction of VWF with collagen type III and ristocetin- or botrocetin-induced platelet aggregation. Here, we identified the epitopes recognized by SZ-123 and SZ-125 using matrix-assisted laser desorption ionization mass spectrometry in combination with proteolysis protection assays. Our results demonstrated that SZ-123 recognizes a discontinuous epitope, involving the residues (989)AHLLSLVDVMQR(1000) and (1017)YLTSEMHGA... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5112147 Fri, 05 Aug 2011 23:00:00 +0100 5112147 http://www.medworm.com/index.php?rid=5112148&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21814881%26dopt%3DAbstract Authors: Liu H, Chiang MY, Pear WS NOTCH1 plays a central role in T-cell development and, when aberrantly activated, in acute T-cell lymphoblastic leukemia (T-ALL). As a transmembrane receptor that is ultimately converted into a transcription factor, NOTCH1 directly activates a spectrum of target genes, which function to mediate NOTCH1 signaling in normal or transformed T cells. During physiologic T-cell development, NOTCH1 has important functions in cell fate determination, proliferation, survival and metabolism. Activating NOTCH1 mutations occur in more than half of human patients with T-ALL, suggesting an important role for aberrant NOTCH1 signaling in the pathogenesis of this disease. Inhibiting NOTCH1 signaling in patient-derived cell lines and murine T-ALLs leads to growth arrest... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5112148 Thu, 04 Aug 2011 23:00:00 +0100 5112148 http://www.medworm.com/index.php?rid=5112150&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21811773%26dopt%3DAbstract Authors: Urata C, Yoshimura M, Itamura H, Hisatomi T, Kubota Y, Fukushima N, Sueoka E, Kimura S PMID: 21811773 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5112150 Tue, 02 Aug 2011 23:00:00 +0100 5112150 http://www.medworm.com/index.php?rid=5112149&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21811774%26dopt%3DAbstract Authors: Neki R, Fujita T, Kokame K, Nakanishi I, Waguri M, Imayoshi Y, Suehara N, Ikeda T, Miyata T Deep vein thrombosis (DVT) is a serious pregnancy-related complication. Recent studies indicate that the genetic background for DVT differs with ethnicity. In our study, we enrolled 18 consecutive Japanese patients who had developed DVT during pregnancy and postpartum. We performed a genetic analysis of three candidate genes for DVT, protein S, protein C and antithrombin, in these patients. We found that four patients had missense mutations in the protein S gene, including the K196E mutation in two patients, the L446P mutation in one patient, and the D79Y and T630I mutations in one patient, as well as one patient with the C147Y mutation in the protein C gene. All five patients with gene... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5112149 Tue, 02 Aug 2011 23:00:00 +0100 5112149 http://www.medworm.com/index.php?rid=5112153&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21800074%26dopt%3DAbstract Authors: Iwamoto S, Deguchi T, Ohta H, Kiyokawa N, Tsurusawa M, Yamada T, Takase K, Fujimoto J, Hanada R, Hori H, Horibe K, Komada Y Although the antigen expression patterns of childhood acute lymphoblastic leukemia (ALL) are well known, little attention has been given to standardizing the diagnostic and classification criteria. We retrospectively analyzed the flow cytometric data from a large study of antigen expression in 1,774 children with newly diagnosed ALL in JPLSG. T- and B-lineage ALL accounted for 13 and 87% of childhood ALL cases, respectively. Cytoplasmic CD3 and CD7 antigens were positive in all T-ALL cases. More than 80% of T-ALL cases expressed CD2, CD5 and TdT. In B-lineage ALL, the frequencies of early pre-B, pre-B, transitional pre-B and B-ALL were 81, 15.5, 0.6 and 2... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5112153 Fri, 29 Jul 2011 23:00:00 +0100 5112153 http://www.medworm.com/index.php?rid=5112154&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21800073%26dopt%3DAbstract Authors: Heidel FH, Mar BG, Armstrong SA A key characteristic of hematopoietic stem cells (HSC) is the ability to self-renew. Several genes and signaling pathways control the fine balance between self-renewal and differentiation in HSC and potentially also in leukemic stem cells. Besides pathways such as Wnt signaling, Hedgehog signaling and Notch signaling, transcription factors (FoxOs) and cell fate determinants may also play a role in stem cells. While some of these pathways seem to be dispensable for maintenance of adult HSC, there may be a distinct requirement in leukemia stem cells for leukemic self-renewal. Here we will focus on self-renewal related signaling in myeloid leukemia stem cells and its therapeutic relevance. PMID: 21800073 [PubMed - as supplied by publisher] (Sou... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5112154 Thu, 28 Jul 2011 23:00:00 +0100 5112154 http://www.medworm.com/index.php?rid=5112152&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21800075%26dopt%3DAbstract Authors: Zhu YJ, Huang JJ, Xia Y, Zhao W, Jiang WQ, Lin TY, Huang HQ, Li ZM Primary mediastinal large B-cell lymphoma (PMLBCL) is a unique clinico-pathological subtype, for which there is no optimal therapy yet. We evaluated clinical characteristics and prognostic factors in 39 consecutive, previously untreated Chinese patients with PMLBCL. The median age was 28 years (range 16-72 years). The majority of patients were stage I/II (23 cases, 59%). Bulky mediastinal mass was present in 18 cases (46%). The 3-year overall survival (OS) and progression-free survival (PFS) rates were 70 and 64%, respectively. Cox regression analysis showed that low serum albumin was an independent prognostic predictor of both OS (P = 0.002) and PFS (P = 0.001). Other prognostic factors for OS were extra... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5112152 Thu, 28 Jul 2011 23:00:00 +0100 5112152 http://www.medworm.com/index.php?rid=5112151&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21800076%26dopt%3DAbstract Authors: Cetin B, Benekli M, Bulutay P, Akyurek N, Cura E, Coskun U, Buyukberber S Sister Mary Joseph's periumbilical metastatic nodule is an ominous harbinger of an internal malignancy usually originating from gastrointestinal or genital system primary cancers. At the time of diagnosis, they are inoperable and therefore deemed incurable, suggesting an invariably dismal prognosis. Periumbilical neoplastic deposits from primary non-Hodgkin's lymphoma are extremely rare. A 72-year-old white male with a history of gastric cancer was referred with a painful lesion in the umbilicus. A delayed biopsy of the nodule showed diffuse large B-cell lymphoma. After a work up, he was successfully treated with standard combination chemotherapy and achieved complete remission. However, the patient deve... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5112151 Thu, 28 Jul 2011 23:00:00 +0100 5112151 http://www.medworm.com/index.php?rid=5112155&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21766185%26dopt%3DAbstract Authors: Heng LL, Caguioa P, Chin NS, Chiou TJ, Lee JW, Miyakawa Y, Tambunan KL, Chong BH Patients with primary immune thrombocytopenia (ITP) from the Asia-Pacific region often exhibit characteristics distinct from those of patients from the West. Moreover, as the region itself is heterogeneous, the ITP landscape among individual Asia-Pacific countries can be diverse. The recently released international consensus report on ITP places new emphasis on ITP, but does not address the unique ITP landscape in the Asia-Pacific region, which is home to 60% of the world's population. In an attempt to characterize how the ITP landscape differs between the West and the Asia-Pacific region, an expert panel with representatives from Northeast Asia, Southeast Asia, and Australia was convened. Importa... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5112155 Fri, 15 Jul 2011 23:00:00 +0100 5112155 http://www.medworm.com/index.php?rid=5112157&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21751081%26dopt%3DAbstract Authors: Miura K, Takei K, Kobayashi S, Kiso S, Hirabayashi Y, Hojo A, Kodaira H, Yagi M, Kurita D, Kobayashi Y, Tanaka T, Iriyama N, Hatta Y, Kura Y, Yamazaki T, Sawada U, Takeuchi J PMID: 21751081 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5112157 Wed, 13 Jul 2011 23:00:00 +0100 5112157 http://www.medworm.com/index.php?rid=5112156&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21751082%26dopt%3DAbstract Authors: Wakahashi K, Yamamori M, Minagawa K, Ishii S, Nishikawa S, Shimoyama M, Kawano H, Kawano Y, Kawamori Y, Sada A, Matsui T, Katayama Y Mycophenolate mofetil (MMF) has been widely used for prophylaxis against graft-versus-host disease (GVHD) following allogeneic hematopoietic stem cell transplantation (allo-SCT). However, no clear advantage over methotrexate has been reported, other than reduced incidence of mucositis. We speculated that the wide inter-individual variation of plasma mycophenolic acid (MPA) levels veiled the benefits of MMF. Data from 36 unrelated allogeneic bone marrow (allo-BMT) and cord blood transplantation (CBT) were analyzed retrospectively based on MPA area under the curve (AUC(0-24h)). In allo-BMT, high AUC(0-24h) (>30 μg h/ml) resulted in no inciden... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5112156 Wed, 13 Jul 2011 23:00:00 +0100 5112156 http://www.medworm.com/index.php?rid=5019394&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21744130%26dopt%3DAbstract Authors: Yamanouchi J, Hato T, Niiya T, Hayashi T, Suzuki K, Yasukawa M PMID: 21744130 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5019394 Fri, 08 Jul 2011 23:00:00 +0100 5019394 http://www.medworm.com/index.php?rid=5019397&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21732036%26dopt%3DAbstract In conclusion, neutrophil distribution parameters, especially 90D NDW, appear to provide convenient and objective markers for the screening of patients with MDS in routine laboratory hematology. PMID: 21732036 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5019397 Tue, 05 Jul 2011 23:00:00 +0100 5019397 http://www.medworm.com/index.php?rid=5019396&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21732037%26dopt%3DAbstract Authors: Wang H, Chen XQ, Geng QR, Liu PP, Lin GN, Xia ZJ, Lu Y Patients with newly diagnosed acute lymphoblastic leukemia (ALL) at a single institution were analyzed retrospectively. From 2006 to 2010, 47 patients were treated using the MRC UKALLXII/ECOG E2993 protocol. Prior to July 2005, 40 patients had been treated with the JALSG ALL 87 protocol. A complete remission (CR) rate of 91.5% was achieved with the E2993 protocol, which was not significantly higher than the 80% achieved using JALSG (P > 0.05). The median duration of CR in months was 19 for all patients treated with the MRC UKALLXII/ECOG E2993 protocol. Ph+ patients showed a median CR duration of 11.5 months, while Ph- patients had a significantly longer CR duration of 19 months (P = 0.019). Further, Ph- patients a... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5019396 Tue, 05 Jul 2011 23:00:00 +0100 5019396 http://www.medworm.com/index.php?rid=5019395&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21732038%26dopt%3DAbstract Authors: Shirasaki R, Tashiro H, Oka Y, Sugao T, Yamamoto T, Yoshimi M, Akiyama N, Kawasugi K, Shirafuji N The vascular endothelial growth factor (VEGF)-C system was analyzed in two cases of acute lymphocytic leukemia (ALL) with TCF3/PBX1 fusion to determine whether the VEGF-C system influences the growth of these ALL blasts. Bone marrow non-adherent mononuclear cells were prepared from the patients, and expressions of VEGFs and VEGF receptors (VEGFRs) were analyzed based on RNA and protein levels. Cell proliferation was also assayed with or without neutralizing antibodies to VEGFs. The patients' leukemic blasts expressed a significant amount of VEGF-C and VEGFR type-3. When anti-VEGF-C antibody was added to the blast cell cultures, cell proliferation was suppressed. These observations... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5019395 Tue, 05 Jul 2011 23:00:00 +0100 5019395 http://www.medworm.com/index.php?rid=5019398&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21728004%26dopt%3DAbstract In conclusion, the present study reveals the potential clinical value of berbamine in the treatment of CML with imatinib-induced neutropenia. The use of berbamine may improve response to imatinib by stimulating normal hematopoiesis and faster neutropenia recovery. PMID: 21728004 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5019398 Mon, 04 Jul 2011 23:00:00 +0100 5019398 http://www.medworm.com/index.php?rid=5019400&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21706145%26dopt%3DAbstract In conclusion, romiplostim significantly increased and maintained platelet counts and was well tolerated in Japanese patients with ITP. PMID: 21706145 [PubMed - in process] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5019400 Thu, 30 Jun 2011 23:00:00 +0100 5019400 http://www.medworm.com/index.php?rid=5019399&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21713401%26dopt%3DAbstract Authors: Cheng T PMID: 21713401 [PubMed - in process] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=5019399 Thu, 30 Jun 2011 23:00:00 +0100 5019399 http://www.medworm.com/index.php?rid=4971906&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21695600%26dopt%3DAbstract In this study, a total of 32 patients with a median age of 64 years (range 38-79) who received an average of 2.6 cycles of R-IVAD from 2001 to 2009 in our institution were retrospectively analyzed. R-IVAD was given every 3 weeks up to a total of three courses with support by granulocyte colony stimulating factor. The overall response rate was 72%, with 56% complete response. On a median follow-up of 16 months (range 2-99), estimated 2-year overall survival (OS) and event-free survival were 55% and 36%, respectively. Of these patients, 10 successfully proceeded to consolidating high-dose chemotherapy followed by autologous stem cell transplantation, accounting for 90% of the 2-year OS. No treatment-related mortality was observed during the investigation. We, therefore, conclude that R-IV... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4971906 Wed, 22 Jun 2011 23:00:00 +0100 4971906 http://www.medworm.com/index.php?rid=4971901&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21698356%26dopt%3DAbstract Authors: Cui Q, Shibata H, Oda A, Amou H, Nakano A, Yata K, Hiasa M, Watanabe K, Nakamura S, Miki H, Harada T, Fujii S, Kagawa K, Takeuchi K, Ozaki S, Matsumoto T, Abe M Multiple myeloma (MM) cells stimulate osteoclastogenesis, and osteoclasts (OCs) in turn enhance MM growth and drug resistance, resulting in a vicious cycle. Vγ9Vδ2 T cells exert potent anti-tumor effects, making T cell-based immunotherapies using these cells attractive candidates for currently incurable malignancies, such as MM. However, the impact of such treatments on the MM-OC interaction is largely unknown. We demonstrate here that Vγ9Vδ2 T cells expanded by zoledronic acid and IL-2 exerted potent cytotoxic effects on both MM cells and OCs, even in coculture settings, but showed no such effect on bone marrow st... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4971901 Wed, 22 Jun 2011 23:00:00 +0100 4971901 http://www.medworm.com/index.php?rid=4971910&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21674360%26dopt%3DAbstract In this study, we aimed to evaluate the relationship between MPO positivity and gene mutations found in normal karyotypes. Sixty AML patients with normal karyotypes were included in this study. Blast cell MPO positivity was assessed in bone marrow smears stained for MPO. Associated genetic lesions (the NPM1, FLT3-ITD, and CEBPA mutations) were studied using nucleotide sequencing. Thirty-two patients were in the MPO-L group, and 28 patients in the MPO-H group. FLT3-ITD was found in 11 patients (18.3%), NPM1 mutations were found in 19 patients (31.7%), and CEBPA mutations were found in 11 patients (18.3%). In patients with CEBPA mutations, the carrying two simultaneous mutations (CEBPA (double-mut)) was associated with high MPO expression, while the mutant NPM1 without FLT3-ITD genotype was ... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4971910 Wed, 15 Jun 2011 23:00:00 +0100 4971910 http://www.medworm.com/index.php?rid=4971914&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21671044%26dopt%3DAbstract Authors: Ju Z, Zhang J, Gao Y, Cheng T Stem cells are believed to be closely associated with tissue degeneration during aging. Studies of human genetic diseases and gene-targeted animal models have provided evidence that functional decline of telomeres and deregulation of cell cycle checkpoints contribute to the aging process of tissue stem cells. Telomere dysfunction can induce DNA damage response via key cell cycle checkpoints, leading to cellular senescence or apoptosis depending on the tissue type and developmental stage of a specific stem cell compartment. Telomerase mutation and telomere shortening have been observed in a variety of hematological disorders, such as dyskeratosis congenital, aplastic anemia, myelodysplastic syndromes and leukemia, in which the hematopoietic stem ce... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4971914 Mon, 13 Jun 2011 23:00:00 +0100 4971914 http://www.medworm.com/index.php?rid=4923761&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21660439%26dopt%3DAbstract In this study, we have constructed wild-type deletion mutants of the critical domains and disease-associated mutants of the SBDS gene. These constructs were expressed in HeLa cells to explore the subcellular distribution of normal and mutant proteins. Wild-type SBDS was detected in the nucleus. However, constructs lacking N-terminal Domain I and two disease-associated mutants (C31W and N34I) failed to localize SBDS to the nucleus. Moreover, the amount of mutated SBDS protein was decreased. When N-terminal Domain I was overexpressed in HeLa cells, the localization of endogenous SBDS protein was changed from nuclei to cytosolic fraction. These data indicate that the N-terminal Domain I is responsible for nuclear localization. Furthermore, low expression of SBDS, as exhibited in some of the d... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4923761 Thu, 09 Jun 2011 23:00:00 +0100 4923761 http://www.medworm.com/index.php?rid=4923763&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21647608%26dopt%3DAbstract We present a patient with iron overload, who was initially diagnosed with hereditary haemochromatosis. Family analysis, however, established that the iron overload was secondary to congenital sideroblastic anaemia. The patient died of a hepatocellular carcinoma, likely a complication of iron overload, despite phlebotomies. Increased awareness, as well as development of evidence-based clinical guidelines, is required for timely diagnosis and adequate treatment. PMID: 21647608 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4923763 Tue, 07 Jun 2011 23:00:00 +0100 4923763 http://www.medworm.com/index.php?rid=4923762&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21647609%26dopt%3DAbstract This study demonstrates that the combination of mTPO and mNUDC provides additive induction of megakaryocyte maturation in vitro and platelet production in vivo. PMID: 21647609 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4923762 Mon, 06 Jun 2011 23:00:00 +0100 4923762 http://www.medworm.com/index.php?rid=4923766&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21643693%26dopt%3DAbstract Authors: Sato T, Iyama S, Murase K, Kamihara Y, Ono K, Kikuchi S, Takada K, Miyanishi K, Sato Y, Takimoto R, Kobune M, Kato J Iron-refractory iron deficiency anemia (IRIDA) is a rare autosomal-recessive disorder hallmarked by hypochromic microcytic anemia, low transferrin saturation, and unresponsiveness to oral iron with partial recovery after parenteral iron administration. The disease is caused by mutations in TMPRSS6 (transmembrane protease serine 6) that prevent inactivation of membrane-bound hemojuvelin, an activator of hepcidin transcription. To date, 38 cases have been characterized and reported in European countries and the United States. In this paper, we describe the first case of a Japanese female with IRIDA, who carried a novel mutation (K253E) in the CUB (complement facto... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4923766 Fri, 03 Jun 2011 23:00:00 +0100 4923766 http://www.medworm.com/index.php?rid=4923764&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21643694%26dopt%3DAbstract Authors: Iriyama N, Horikoshi A, Tanaka T, Hirabayashi Y, Kodaira H, Hatta Y, Takeuchi J A 34-year-old woman at 18 weeks of gestation during her third pregnancy was diagnosed with Hodgkin lymphoma stage IVA. She was treated with standard ABVD and showed good response. After three-and-a-half courses of ABVD, she spontaneously delivered a healthy baby girl at 41 weeks of gestation. She continued chemotherapy after delivery. A total of six courses of ABVD were given. Complete remission was obtained and has continued for 6 months post chemotherapy. Neither mother nor child developed any infections during the observation period. The child has also shown no physiological or developmental abnormalities. Here, we describe the feasibility and safety of the ABVD regimen for the treatment of H... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4923764 Fri, 03 Jun 2011 23:00:00 +0100 4923764 http://www.medworm.com/index.php?rid=4923770&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21626104%26dopt%3DAbstract Authors: Matsubayashi T, Shimizu S, Kitazawa H, Matsubayashi R, Tobayama S PMID: 21626104 [PubMed - in process] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4923770 Tue, 31 May 2011 23:00:00 +0100 4923770 http://www.medworm.com/index.php?rid=4923769&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21626105%26dopt%3DAbstract In this study, we have identified FAS gene mutations in three Japanese patients with lymphadenopathy, hepatosplenomegaly, and unusual EBV infection, who were diagnosed with CAEBV. These observations, which indicate that the clinical development of ALPS may be associated with EBV infection, alert us to a potential diagnostic pitfall of CAEBV. PMID: 21626105 [PubMed - in process] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4923769 Tue, 31 May 2011 23:00:00 +0100 4923769 http://www.medworm.com/index.php?rid=4923768&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21626106%26dopt%3DAbstract Authors: Rusak M, Osada J, Pawlus J, Chociej-StypuÅ‚kowska J, DÄ…browska M, KÅ‚oczko J The study objective was to analyse the utility of laboratory tests performed in 30 patients with B-cell chronic lymphocytic leukaemia (B-CLL) at different clinical stages. Laboratory tests included automated and microscopic assessment of peripheral blood and bone marrow counts as well as evaluation of leukaemic cells. Apart from the diagnostic and prognostic value of laboratory abnormalities such as clonal lymphocytosis with CD5+CD19+CD23+ phenotype, reduced erythrocyte parameters, thrombocytopenia or bone marrow infiltration by the neoplastic clone as well as low percentage of Gumprecht's shadows, low apoptotic activity of peripheral blood lymphocytes, and increased percentage of CD38- and ZAP-70 Â... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4923768 Tue, 31 May 2011 23:00:00 +0100 4923768 http://www.medworm.com/index.php?rid=4923767&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21626456%26dopt%3DAbstract Authors: Kobune M, Miyanishi K, Takada K, Kawano Y, Nagashima H, Kikuchi S, Murase K, Iyama S, Sato T, Sato Y, Takimoto R, Kato J Recent studies on iron metabolism have begun to reveal the molecular mechanisms underlying iron absorption, which is dramatically affected in several disorders. In the clinical setting, the ability to determine the status of iron absorption would aid in the diagnosis of pathological conditions. Efforts to develop an oral iron absorption test (OIAT) date back to at least 60 years. However, previous procedures were associated with a number of problems, such as radiation exposure and low reproducibility. In an attempt to resolve these issues, we employed sodium ferrous citrate (SFC), by which the influence of various nutrients and drugs on iron absorption was ... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4923767 Tue, 31 May 2011 23:00:00 +0100 4923767 http://www.medworm.com/index.php?rid=4877208&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21617886%26dopt%3DAbstract Authors: Kojima S, Nakao S, Young N, Bacigalupo A, Gerard G, Hirano N, Maciejewski J, Deeg J, Marsh J, Zhang FK, Lee JW, Ozawa K PMID: 21617886 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4877208 Thu, 26 May 2011 23:00:00 +0100 4877208 http://www.medworm.com/index.php?rid=4877206&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21617888%26dopt%3DAbstract In this study, we investigated whether rAAV2 could also mediate the expression of normal β-globin gene in human hematopoietic cells from β-thalassemia patients. Human hematopoietic cells were isolated from aborted β-thalassemia major fetuses, transduced with rAAV2-β-globin, and then transplanted into nude mice. We found that rAAV2-β-globin transduced human fetal hematopoietic cells, as determined by allele-specific PCR analysis. Furthermore, β-globin transgene expression was detected in human hematopoietic cells up to 70 days post-transplantation in the recipient mice. High-pressure liquid chromatography analysis showed that human β-globin expression levels increased significantly compared with control, as indicated by a 1.2-2.8-fold increase in the ratio of β/α-globin chain. The... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4877206 Thu, 26 May 2011 23:00:00 +0100 4877206 http://www.medworm.com/index.php?rid=4877211&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21607654%26dopt%3DAbstract Authors: Tsubokura M, Yamashita T, Kageyama SI, Endo I, Tsuda H, Akiyama H PMID: 21607654 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4877211 Tue, 24 May 2011 23:00:00 +0100 4877211 http://www.medworm.com/index.php?rid=4877209&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21611719%26dopt%3DAbstract Authors: Röth A, Hock C, Konik A, Christoph S, Dührsen U The terminal complement inhibitor eculizumab has become the standard of treatment in patients with symptomatic paroxysmal nocturnal hemoglobinuria (PNH). In this retrospective study, 19 PNH patients received chronic therapy with eculizumab with a median duration of 16 months (range 6-46 months). Parameters of hemolysis, transfusion requirements, and serum iron parameters were analyzed. Lactate dehydrogenase levels were significantly decreased by 85% from a median of 1897 U/l (range 293-3360) to 283 U/l (range 143-667), with an 86% reduction of transfusion requirements, whereas other parameters of hemolysis remained abnormal. Six patients (31.6%) became completely transfusion independent. A significant increase in ferritin l... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4877209 Tue, 24 May 2011 23:00:00 +0100 4877209 http://www.medworm.com/index.php?rid=4877207&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21617887%26dopt%3DAbstract Authors: Demirel G, Akar M, Celik IH, Erdeve O, Uras N, Oguz SS, Dilmen U Intravenous immunoglobulin (IVIG) has been found to decrease hemolysis in neonatal jaundice due to blood group incompatibility, but a consensus on its usage has not been reached. We conducted a study to compare single versus multiple dose of IVIG in combination with light emitting diode (LED) phototherapy in patients with neonatal jaundice secondary to ABO blood incompatibility, and compared the efficacy of these treatments with that in a group of patients who received LED phototherapy solely. Thirty-nine term neonates with ABO blood group incompatibility were enrolled in the study. Group I received one dose of IVIG (1 g/kg) and LED phototherapy, and group II two doses of IVIG (1 g/kg) and LED phototherapy, whe... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4877207 Tue, 24 May 2011 23:00:00 +0100 4877207 http://www.medworm.com/index.php?rid=4877210&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21607655%26dopt%3DAbstract This study is to test the hypothesis that acute myeloid leukemia (AML) alters the expression of SDF-1/CXCR4 in human bone marrow MSCs. Expression of both CXCR4 and SDF-1 was found to be increased, but excessively retained, in the MSCs in AML. In contrast, the SDF-1 level in bone marrow plasma and supernatant of cultured MSCs from AML patients were reduced, while the SDF-1 was able to efficiently induce a dose-dependent migration of MSCs in vitro. Our results demonstrate that altered expression and distribution of SDF-1/CXCR4 in MSCs may contribute to SDF-1 deficiency in the plasma of AML patients. The migration of MSCs may be negatively affected by the SDF-1 deficiency. PMID: 21607655 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4877210 Mon, 23 May 2011 23:00:00 +0100 4877210 http://www.medworm.com/index.php?rid=4877213&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21594763%26dopt%3DAbstract Authors: Kobayashi Y, Sakamaki H, Fujisawa S, Ando K, Yamamoto K, Okada M, Ishizawa K, Nagai T, Miyawaki S, Motoji T, Usui N, Iida S, Taniwaki M, Uoshima N, Seriu T, Ohno R The aim of this retrospective study was to evaluate the toxicity profiles of dasatinib in patients with Philadelphia chromosome positive chronic myeloid leukemia (CML) or acute lymphatic leukemia (ALL) who were intolerant to imatinib, and who had been enrolled in our previous clinical trials to evaluate efficacy of dasatinib in patients resistant or tolerant to imatinib therapy. Twenty-four patients with CML and four with ALL were enrolled in the clinical studies to evaluate the efficacy according to the eligibility criteria related to intolerance to imatinib therapy. The toxicities reported during imatinib therapy ... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4877213 Thu, 19 May 2011 23:00:00 +0100 4877213 http://www.medworm.com/index.php?rid=4877212&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21597911%26dopt%3DAbstract Authors: Mori S, Fujita S, Yamamoto Y, Li M, Fukuhara S, Nomura S, Ikehara S We previously described a unique procedure for the collection of bone marrow cells (BMCs) using a perfusion method (PM). In cynomolgus monkeys, this method resulted in lower contamination with T cells (<10%). Here, we performed PM on a poor mobilizer lymphoma patient. We confirmed the safety of the intra-bone marrow injection of saline to collect the BMCs. The collected BMCs showed minimal contamination with T cells (<15%) and red blood cells (RBCs) (<4%) from the peripheral blood. It took a total of only 30 min to collect the BMCs. Moreover, transfusion of RBCs was unnecessary. There were no relevant post-operative side effects except for self-limiting pain at the sites of collection, and the patien... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4877212 Thu, 19 May 2011 23:00:00 +0100 4877212 http://www.medworm.com/index.php?rid=4877216&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21573890%26dopt%3DAbstract Authors: Sakai M, Kubota T, Kuwayama Y, Ikezoe T, Yokoyama A PMID: 21573890 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4877216 Sat, 14 May 2011 23:00:00 +0100 4877216 http://www.medworm.com/index.php?rid=4877215&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21573891%26dopt%3DAbstract Authors: Tanabe T, Yamaguchi N, Matsuda K, Yamazaki K, Takahashi S, Tojo A, Onizuka M, Eishi Y, Akiyama H, Ishikawa J, Mori T, Hara M, Koike K, Kawa K, Kawase T, Morishima Y, Amano H, Kobayashi-Miura M, Kakamu T, Nakamura Y, Asano S, Fujita Y Members of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family participate in the innate immune system, exerting widespread effects on cytokine secretion, autophagy, and apoptosis. Recent studies in Caucasians revealed the association between mutants of NOD2, a member of the NLR family, and severity of acute graft-versus-host disease (GVHD). NOD2 polymorphism screening has been recommended for donor selection and risk assessment at bone marrow transplantation. To investigate whether NOD2 plays a role in the pathogenesis ... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4877215 Sat, 14 May 2011 23:00:00 +0100 4877215 http://www.medworm.com/index.php?rid=4877214&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21573892%26dopt%3DAbstract We describe MR-CHOP therapy, a novel treatment regimen consisting of high-dose methotrexate and R-CHOP that provides systemic anti-tumor activity with penetration of the blood-brain barrier in patients with newly diagnosed primary central nervous system lymphoma. The MR-CHOP regimen was administered with 2 g/m(2) of methotrexate and 375 mg/m(2) of rituximab on day 1, 750 mg/m(2) of cyclophosphamide on day 3, 50 mg/m(2) of doxorubicin on day 3, 1.4 mg/m(2) of vincristine on day 3 and 100 mg of prednisolone on days 1-5 in this pilot study of seven patients. Six cycles of MR-CHOP therapy were administered every 3 weeks, followed by high-dose chemotherapy with stem cell rescue in young patients, or an additional two cycles of 4 g/m(2) methotrexate and rituximab in older patients. The o... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4877214 Sat, 14 May 2011 23:00:00 +0100 4877214 http://www.medworm.com/index.php?rid=4824378&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21567162%26dopt%3DAbstract Authors: Shao L, Li H, Pazhanisamy SK, Meng A, Wang Y, Zhou D Hematopoietic stem cells (HSCs) are responsible for sustaining hematopoietic homeostasis and regeneration after injury for the entire lifespan of an organism through self-renewal, proliferation, differentiation, and mobilization. Their functions can be affected by reactive oxygen species (ROS) that are produced endogenously through cellular metabolism or after exposure to exogenous stress. At physiological levels, ROS function as signal molecules which can regulate a variety of cellular functions, including HSC proliferation, differentiation, and mobilization. However, an abnormal increase in ROS production occurs under various pathological conditions, which can inhibit HSC self-renewal and induce HSC senescence, resulting i... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4824378 Thu, 12 May 2011 23:00:00 +0100 4824378 http://www.medworm.com/index.php?rid=4824377&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21567163%26dopt%3DAbstract Authors: Tasaka T, Tohyama K, Ohyashiki K, Ozawa K PMID: 21567163 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4824377 Thu, 12 May 2011 23:00:00 +0100 4824377 http://www.medworm.com/index.php?rid=4824381&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21557042%26dopt%3DAbstract Authors: Kanda Y PMID: 21557042 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4824381 Tue, 10 May 2011 23:00:00 +0100 4824381 http://www.medworm.com/index.php?rid=4824380&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21557043%26dopt%3DAbstract Authors: Teng YK, Schippers EF, Wijermans PW The present report describes repeated long-term remissions of a high-grade T cell lymphoma in an HIV-positive patient upon cART only, without additional chemotherapy. A review of cases from the literature further illustrates the anti-tumor effects of cART through the induction of a strong immune reconstitution in HIV-infected patients. PMID: 21557043 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4824380 Tue, 10 May 2011 23:00:00 +0100 4824380 http://www.medworm.com/index.php?rid=4824379&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21559814%26dopt%3DAbstract Authors: Muramatsu H, Takahashi Y, Shimoyama Y, Doisaki S, Nishio N, Ito Y, Hama A, Shimada A, Yagasaki H, Ito M, Kojima S Epstein-Barr virus-associated post-transplant lymphoproliferative disease (EBV-PTLD) is a life-threatening complication following allogeneic hematopoietic stem cell transplantation (HSCT). Monitoring of EBV DNA in high-risk patients with subsequent pre-emptive rituximab treatment is highly effective, and can prevent EBV-associated disease following HSCT. Here, we report a 10-year-old girl with aplastic anemia who developed CD20 negative EBV-PTLD after unrelated bone marrow transplantation that was refractory to rituximab treatment. Similar to other types of lymphoma, the absence of CD20 antigen is likely to be characteristic of rituximab-refractory EBV-PTLD. PM... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4824379 Tue, 10 May 2011 23:00:00 +0100 4824379 http://www.medworm.com/index.php?rid=4824385&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21547615%26dopt%3DAbstract Authors: Kharfan-Dabaja MA, Cutler CS Growing understanding of the important role of B lymphocytes in alloreactivity has paved the way for evaluating anti-B cell therapy with rituximab in patients undergoing allogeneic hematopoietic cell transplantation. Data suggesting a beneficial reduction in incidence and severity of acute graft-versus-host disease (GVHD) are limited to non-randomized studies from single institutions using higher than conventional doses of rituximab. Additionally, rituximab is used as an effective treatment of corticosteroid-refractory chronic GVHD with good responses, particularly in cases of dermatologic and mucosal involvement. Post-transplant administration of rituximab appears to reduce the rate of chronic GVHD in preliminary studies. PMID: 21547615 [PubMe... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4824385 Fri, 06 May 2011 23:00:00 +0100 4824385 http://www.medworm.com/index.php?rid=4824384&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21553018%26dopt%3DAbstract Authors: Shindo M, Sato K, Yamamoto M, Toki Y, Hatayama M, Ito S, Ichiki K, Okamura N, Hosoki T, Ikuta K, Inamura J, Watanabe S, Torimoto Y, Kohgo Y A 44-year-old male was admitted for numbness in the left arm. CT showed a tumor impacting on the spinal cord with an adjacent thoracic vertebral osteosclerotic lesion. The histopathology of the tumor showed diffuse proliferation of atypical plasma cells with expressed vascular endothelial growth factor (VEGF), which is a known etiological factor in POEMS syndrome. Though serum VEGF (sVEGF) level was elevated, a diagnosis of solitary plasmacytoma with an osteosclerotic lesion was made as the patient presented no polyneuropathy, organomegaly, endocrinopathy, or skin changes. The patient experienced muscle weakness of the lower limbs and skin... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4824384 Fri, 06 May 2011 23:00:00 +0100 4824384 http://www.medworm.com/index.php?rid=4824383&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21553019%26dopt%3DAbstract Authors: Abbass K, Dewani S, Markert R, Kaplon MK, Baumann MA PMID: 21553019 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4824383 Fri, 06 May 2011 23:00:00 +0100 4824383 http://www.medworm.com/index.php?rid=4824382&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21553020%26dopt%3DAbstract In conclusion, the identification of an inflammatory autoimmune neuropathy, presumably associated with bortezomib, is a rare but important complication. An extensive neurological examination should be performed in patients who develop severe or unusual sensory or motor deficits under therapy with bortezomib, so as to differentiate autoimmune from toxic neuropathies, as therapeutic strategies differ for each. PMID: 21553020 [PubMed - as supplied by publisher] (Source: International Journal of Hematology) International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4824382 Fri, 06 May 2011 23:00:00 +0100 4824382 http://www.medworm.com/index.php?rid=4824386&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21537931%26dopt%3DAbstract Authors: Goyama S, Mulloy JC Core binding factor (CBF) acute myeloid leukemia (AML) is the most common cytogenetic subtype of AML, defined by the presence of t(8;21) or inv(16)/t(16;16). The chromosomal aberrations create AML1-ETO and CBFβ-MYH11 fusion genes that disrupt the functions of CBF, an essential transcription factor in hematopoiesis. Despite the relatively good outcome of patients with CBF-AML, only approximately half of the patients are cured with current therapy, indicating the need for improved therapeutic strategies. In this review, we summarize current knowledge regarding altered transcriptional regulation, aberrant signaling pathways, and cooperating genetic events in CBF leukemia, and discuss challenges ahead for translating these findings into the clinic. PMID: 2... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4824386 Mon, 02 May 2011 23:00:00 +0100 4824386 http://www.medworm.com/index.php?rid=4824387&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21526377%26dopt%3DAbstract Authors: Nakano A, Abe M, Oda A, Amou H, Hiasa M, Nakamura S, Miki H, Harada T, Fujii S, Kagawa K, Takeuchi K, Watanabe T, Ozaki S, Matsumoto T Bortezomib-induced peripheral neuropathy (BIPN) emerges as a disabling adverse effect. As rat models for BIPN have demonstrated damage in nerve Schwann cells, we screened for cytoprotective agents to devise a method of rescuing Schwann cells from the cytotoxic effects of bortezomib without compromising its anti-myeloma effects. Schwann cells underwent macroautophagy along with cytoplasmic inclusion body and vacuole formation, and appeared much less susceptible to bortezomib-induced cytotoxicity than did myeloma cells. Vitamin C or N-acetyl-L: -cysteine (NAC) achieved near-complete rescue of Schwann cells treated with bortezomib at 30 nM or les... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4824387 Wed, 27 Apr 2011 23:00:00 +0100 4824387 http://www.medworm.com/index.php?rid=4824392&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21523335%26dopt%3DAbstract Authors: Klauke K, de Haan G Protection of the transcriptional "stemness" network is important to maintain a healthy hematopoietic stem cells (HSCs) compartment during the lifetime of the organism. Recent evidence shows that fundamental changes in the epigenetic status of HSCs might be one of the driving forces behind many age-related HSC changes and might pave the way for HSC malignant transformation and subsequent leukemia development, the incidence of which increases exponentially with age. Polycomb group (PcG) proteins are key epigenetic regulators of HSC cellular fate decisions and are often found to be misregulated in human hematopoietic malignancies. In this review, we speculate that PcG proteins balance HSC aging against the risk of developing cancer, since a disturbance in PcG... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4824392 Tue, 26 Apr 2011 23:00:00 +0100 4824392 http://www.medworm.com/index.php?rid=4824391&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21523336%26dopt%3DAbstract Authors: Chen J Hematopoietic stem cells (HSCs) are found in yolk sac, fetal liver, umbilical cord blood, placenta, and amniotic fluid during mammalian embryonic development. In adults, HSCs reside in marrow cavity of long bones where they self-renew and differentiate to replenish short-lived mature blood cells. HSCs exist in very low frequencies within specific "niches" where they interact with the surrounding environment through molecular associations. Overall HSC function can last much longer than a normal lifetime, but HSCs do show functional senescence with characteristic features of decreased self-renewal, reduced clonal stability, reduced homing and engraftment, and biased lineage commitment. The progressive shortening of telomeres with increasing age, especially under condition... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4824391 Tue, 26 Apr 2011 23:00:00 +0100 4824391 http://www.medworm.com/index.php?rid=4824390&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21523337%26dopt%3DAbstract Authors: Ninomiya S, Kanemura N, Tsurumi H, Kasahara S, Hara T, Yamada T, Moriwaki H A 63-year-old woman presented with leukocytosis (278 × 10(9)/L) with 72% blasts. Bone marrow blast cells showed cytogenetic abnormality with 46,XX, t(9;22), inv(16). Despite achievement of hematological remission by induction chemotherapy, Philadelphia chromosome did not disappear; chronic myeloid leukemia (CML) in blast crisis (BC) was thus diagnosed. The P190 BCR/ABL fusion transcript was detected. Imatinib mesylate introduced a hematological remission of short duration; however, infiltration into the central nervous system occurred, and the patient died 7 months after presentation. Coexistence of inv(16) and t(9:22) has been described in CML-BC and de novo AML, and CML-BC patients always carry P... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4824390 Tue, 26 Apr 2011 23:00:00 +0100 4824390 http://www.medworm.com/index.php?rid=4824389&cid=s_37097_19_f&fid=37097&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21523338%26dopt%3DAbstract Authors: Nakamae H, Shibayama H, Kurokawa M, Fukuda T, Nakaseko C, Kanda Y, Nagai T, Ohnishi K, Maeda Y, Matsuda A, Amagasaki T, Yanada M Recent results from the phase 3 ENESTnd (Evaluating Nilotinib Efficacy and Safety in Clinical Trials-Newly Diagnosed Patients) study have demonstrated superiority of nilotinib over imatinib for the treatment of newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia in the chronic phase (CML-CP). Here, we report results from the Japanese subset of patients in ENESTnd, and assess whether results in this subpopulation are consistent with the overall study population. Seventy-nine Japanese patients with CML-CP were randomized to receive nilotinib 300 mg twice daily (BID) (n = 30), nilotinib 400 mg BID (n = 24) or imatinib 400 mg... International Journal of Hematology journals http://www.medworm.com/rss/comments.php?id=4824389 Tue, 26 Apr 2011 23:00:00 +0100 4824389