International Journal of Immunogenetics via MedWorm.com

Isolation, polymorphism and expression study of two distinct major histocompatibility complex class II B genes from half-smooth tongue sole (Cynoglossus semilaevis)

International Journal of Immunogenetics — Wed, 17 Mar 2010 00:00:00 +0100

Major histocompatibility complex (MHC) class II antigens are important in vertebrate immune system, which present peptides to CD4+ T cells. In the present study, cDNAs encoding MHC class II B gene were isolated from the cDNA library of half-smooth tongue sole (Cynoglossus semilaevis), and the full length cDNA sequences were got by rapid amplification of cDNA ends polymerase chain reaction. The polymorphism of its open reading frame, 3' untranslated region and intron 1 was studied. Nineteen class II B alleles were identified from nine individuals and clustered into two groups, designated as Cyse-DAB and Cyse-DBB. The deduced amino acid sequences among Cyse-DAB and Cyse-DBB alleles shared identities from 94.0% to 99.6% and 92.4% to 99.6%, respectively, while the identities between Cyse-DAB a...

Human leucocyte antigen class II DRB1 and DQB1 associations in human immunodeficiency virus-infected patients of Mumbai, India

International Journal of Immunogenetics — Mon, 15 Mar 2010 00:00:00 +0100

The pathogenesis of human immunodeficiency virus (HIV) infection clearly involves immunoregulatory host factors and products of major histocompatibility complex class II genes, which present antigenic peptides to the T-cell receptor on CD4+ cells, which in turn increase the production of specific antibodies and cytotoxic T lymphocytes. The main objective of this study was to determine the associations of human leucocyte antigen (HLA) DRB1 and DQB1 alleles and their haplotypes in 210 HIV-1-infected patients and compare them with 129 healthy normal individuals with same ethnic background. The HLA DRB1 and DQB1 alleles were genotyped using polymerase chain reaction product and sequence-specific probes for reverse line hybridization, analysed with the Invitrogen Dynal PMP software. Our results...

Changes in frequency of IDDM-associated HLA DQB, CTLA4 and INS alleles

International Journal of Immunogenetics — Sun, 14 Mar 2010 00:00:00 +0100

The incidence of type 1 diabetes is increasing worldwide. In Poland, the number of cases tripled during the last two decades. The aim of this study was to test the hypothesis that the increase may be at least partly explained by a shift in predisposing alleles' frequencies [ndash] resulting from treating the otherwise lethal disease, generally better health care as well as selective pressure imposed by pathogens affecting humankind throughout history. The source of DNA was skeletal remains of 232 individuals excavated in four burial sites, dating back to 11th[ndash]14th centuries. With all necessary precautions required in ancient DNA analysis, frequencies of HLA DQB57, CTLA4+49A/G and INS -23A/T alleles were assessed and compared with available data, characterising contemporary Polish pop...

HLA-B*15 subtypes distribution in Han population in Beijing, China, as compared with those of other populations

International Journal of Immunogenetics — Sun, 14 Mar 2010 00:00:00 +0100

To identify HLA-B*15 subtypes distribution in Han population in Beijing, People's Republic of China, 826 unrelated healthy individuals were typed using the polymerase chain reaction-sequence-based typing method. Within the 246 HLA-B*15 positive individuals, 29 HLA-B*15 alleles were identified, the most predominant of which is B*1501 (40.07%), followed by B*1502 (12.87%), B*1511 (12.87%), B*1518 (9.19%) and B*1532 (3.31%). The distribution of HLA-B*15 subtype frequencies was compared between the Beijing Han, eight other Chinese ethnic minorities and six Chinese populations covering the mainland of China, Taiwan, Hong Kong and Singapore. A neighbor-joining phylogenetic tree was constructed and revealed that the Beijing Han population clustered into the northern populations group and had a cl...

Analysis of DEFB1 regulatory SNPs in cystic fibrosis patients from North-Eastern Italy

International Journal of Immunogenetics — Thu, 25 Feb 2010 00:00:00 +0100

Cystic fibrosis (CF) transmembrane regulator protein (CFTR) gene is undoubtedly the main genetic factor involved in the modulation of CF phenotype. However, other factors such as human defensins and the genes encoding for these antimicrobial peptides have been hypothesized as possible modifiers influencing airways infection in CF patients, but their role in the pathogenesis of lung disease is still debated. Since DEFB1 gene encoding for human beta-defensin 1 displays features such as antimicrobial or chemotactic activity playing a role in inflammation, it has been considered as a possible candidate CF modifier gene. We analysed three single nucleotide polymorphisms (SNPs) in the 5'-untranslated region of the DEFB1 gene (namely g-52G>A, g-44C>G and g-20G>A) in a group of 62 CF patients from...

Compound KIR-HLA genotype analyses in the Iranian population by a novel PCR–SSP assay

International Journal of Immunogenetics — Wed, 24 Feb 2010 00:00:00 +0100

In this study, we presented a novel combined KIR-HLA polymerase chain reaction[ndash]sequence-specific primers genotyping assay for simultaneous determination of KIR genes and their three major HLA class I ligand groups (C1, C2, and Bw4). Moreover, known inhibitory and activating KIR + HLA (iKIR + HLA: 2DL2/3 + C1, 2DL1 + C2, 3DL1 + Bw4; and aKIR + HLA: 2DS2 + C1, 2DS1 + C2, 3DS1 + Bw4) combinations as well as co-inheritance of aKIR genes and iKIR + HLA pairs were analysed in a total of 200 unrelated healthy Iranian individuals. All tested subjects had at least one of the three iKIR + HLA pairs and the frequencies of various inhibitory combinations in the study group were: 31.5%, three iKIR + HLA pairs, 53.5%, two iKIR + HLA pairs, and 15%, 0ne iKIR + HLA pair. Furthermore, we revealed tha...

Association of mannose-binding lectin polymorphisms and HBV outcome in a South Indian population

International Journal of Immunogenetics — Wed, 24 Feb 2010 00:00:00 +0100

In this study, we ascertained the association of MBL genotypes with HBV outcome in a South Indian population. The MBL gene polymorphisms at codons 52, 54 and 57 of exon I, and promoter polymorphisms at [minus]221 were typed by polymerase chain reaction-sequence specific primer in spontaneously recovered and in chronic HBV group. The allele frequency of codon 52 'C' was significantly higher in chronic HBV group than in the recovered group (98.5% vs. 93.6%; P = 0.003) and codon 52 'T' was significantly higher in recovered group than in the chronic group (6.4% vs. 1.5%; P = 0.003). In multivariate analysis, after adjusting for age, sex and state of origin, codon 52 'CC' and 'CT' genotypes were significantly associated with chronicity and recovery respectively [odds ratio (OR), 0.25; 95% confi...

BCL10 as a new candidate gene for immune response in pigs: cloning, expression and association analysis

International Journal of Immunogenetics — Fri, 19 Feb 2010 00:00:00 +0100

In this study, we cloned and characterized BCL10 from the porcine spleen and analysed its genomic structure. BCL10 was mapped to SSC4q21[ndash]q23 by the IMpRH panels, it is closely linked to the marker S0161 and SW1461. This gene has three exons and two introns. Reverse transcriptase-polymerase chain reaction analyses showed that BCL10 was widely expressed in all the examined tissues. Transient transfection indicated that porcine BCL10 was located in cytoplasm in Pig Kidney Epithelial cells. BCL10 gene displays the opposite expression trend between the two treatments mimic virus and bacteria of polyriboinosinic-polyribocytidylic acid (Poly I:C) and lipopolysaccharide (LPS). The level of the BCL10 mRNA was up-regulated during 12[ndash]24 h and peaking at 48 h when treated with LPS, whereas...

The mutations of Th1 cell-specific T-box transcription factor may be associated with a predominant Th2 phenotype in gastric cancers

International Journal of Immunogenetics — Fri, 19 Feb 2010 00:00:00 +0100

Gastric cancer is a serious public health cancer and causes nearly 1 million deaths a year worldwide. Th1 cells play critical roles in orchestrating the adaptive immune responses against gastric cancer. T-bet, a member of the T-box family of transcription factors, is the Th1 master regulator and up-regulated during Th1 differentiation. Polymorphisms have also been shown to exist in T-bet. Some reports indicated that some tumours were associated with the drift of Th1 and Th2. In the present work, we investigated the drift of Th1/Th2 by detecting the expression levels of T-bet, IFN-[gamma], IL-4, and GATA-3 in peripheral blood mononuclear cell of gastric cancer patients by real-time PCR, explored the relationship between the polymorphism of T-bet gene and drift of Th1/Th2 by gene sequence, w...

Highly sensitivity adhesion molecules detection in hereditary haemochromatosis patients reveals altered expression

International Journal of Immunogenetics — Fri, 19 Feb 2010 00:00:00 +0100

This study observes for the first time that an altered adhesion molecules profile occurs in patients with HH that is associated with specific HFE genetic component for iron overload, suggesting that differential expression of adhesion molecules may play a role in the pathogenesis of HH. (Source: International Journal of Immunogenetics)

AKT1 polymorphisms are associated with tuberculosis in the Chinese population

International Journal of Immunogenetics — Sat, 06 Feb 2010 00:00:00 +0100

In conclusion, our result indicates that AKT1 polymorphisms are associated with susceptibility to pulmonary TB. (Source: International Journal of Immunogenetics)

Dimorphism of TAP-1 gene in Caucasian with juvenile myoclonic epilepsy and in Tunisian with idiopathic generalized epilepsies

International Journal of Immunogenetics — Fri, 05 Feb 2010 00:00:00 +0100

In this study, we report an association between two TAP-1 functional polymorphisms the I333V and the D637G and most common IGE in Tunisian population, but we fail to find significant results in Caucasian with JME. (Source: International Journal of Immunogenetics)

FcεRIα gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients

International Journal of Immunogenetics — Fri, 05 Feb 2010 00:00:00 +0100

Two promoter polymorphisms of the high-affinity IgE receptor [alpha]-subunit (Fc[epsilon]RI[alpha]) gene (FCER1A), [minus]66T>C (rs2251746) and [minus]315C>T (rs2427827), were analysed in Japanese atopic dermatitis subjects. Patients with the [minus]315CT/TT genotype tended to have higher total serum IgE levels, while the proportion of [minus]315CT/TT genotype or the [minus]315T allele was significantly higher in those with highly elevated total serum IgE concentrations. (Source: International Journal of Immunogenetics)

Nomenclature for factors of the HLA system, update October 2009

International Journal of Immunogenetics — Tue, 02 Feb 2010 00:00:00 +0100

(Source: International Journal of Immunogenetics)

Nomenclature for factors of the HLA system, update November 2009

International Journal of Immunogenetics — Tue, 02 Feb 2010 00:00:00 +0100

(Source: International Journal of Immunogenetics)

Nomenclature for factors of the HLA system, update December 2009

International Journal of Immunogenetics — Tue, 02 Feb 2010 00:00:00 +0100

(Source: International Journal of Immunogenetics)

TNF-α promoter polymorphisms in multiple sclerosis: no association with −308 and −238 alleles, but the −857 alleles in associated with the disease in Turkish patients

International Journal of Immunogenetics — Fri, 15 Jan 2010 00:00:00 +0100

The objective of this study is to investigate the association between TNF-[alpha] promoter region (TNF-[alpha][minus]238, [minus]308 and [minus]857) and susceptibility to MS and clinical course of the disease. Eighty-six relapsing remitting MS patients and 150 sex-, age- and ethnic-matched controls were enrolled in the study. Genotyping was performed by PCR-RFLP method. We observed a statistically significant increase in TNF-[alpha] 857 CC genotype in MS patients than controls (P < 0.001) while TNF-[alpha] 857 CT genotype showed a significant negative correlation with MS patients (P = 0.033). No differences in the distribution of the TNF-[alpha][minus]238 and [minus]308 alleles were observed. None of the three polymorphisms ([minus]238, [minus]308 and [minus]857) did not show relation with...

Analysis of cytokine genes polymorphism as markers for inhibitor development in haemophilia A

International Journal of Immunogenetics — Thu, 14 Jan 2010 00:00:00 +0100

Antibodies that block factor VIII (FVIII) activity appear in some haemophilia A patients treated with FVIII replacement therapy and severely impaired treatment. To date, the mechanisms that lead to this immune response are unknown. In this work, haplotypes of cytokine interleukin 10 (IL-10) gene have been associated with the presence of FVIII inhibitors in a group of Brazilian haemophilia A patients. The coexistence of a haplotype defining high IL-10 synthesis and one defining an intermediate production of cytokines is found to be associated with the group of patients who have a history of inhibitor development. Additionally, the coexistence of haplotypes defining high and low IL-10 syntheses is strongly associated with the group of negative inhibitors. These results have shown that the si...

Killer cell immunoglobulin-like receptor gene diversity in a Caucasian population of Southern Brazil

International Journal of Immunogenetics — Thu, 14 Jan 2010 00:00:00 +0100

This study demonstrated the diversity of KIR genes and of KIR/HLA association in a Caucasian group of Southern Brazil, establishing differences and similarities to other different populations. (Source: International Journal of Immunogenetics)

Immunity-related gene single nucleotide polymorphisms associated with Rhodococcus equi infection in foals

International Journal of Immunogenetics — Thu, 03 Dec 2009 00:00:00 +0100

In previous work, we found significant associations of horse polymorphic microsatellite and immunity-related (IR) gene markers with Rhodococcus equi infection of foals. Here, a statistically significant association between a single nucleotide polymorphism (SNP) within the interleukin 7 receptor-encoding gene (IL7R) with high R. equi burden in transtracheal aspirates was found (Fisher's F = 0.043, odds ratio: 8.00, 95% confidence interval: 1.127[ndash]56.795). Further positional and/or functional candidate genes investigated TLR2, IL13, IL17A, IL28R, TACE/ADAM 17 and GBP1, were not associated with infection in this study. SNPs analysed were found by sequencing and appropriate restriction fragment length polymorphism markers were developed. Their associations with R. equi infection were test...

Study on VNTR polymorphism of gene IL-1RA in 19 Chinese populations

International Journal of Immunogenetics — Thu, 03 Dec 2009 00:00:00 +0100

Earlier studies suggested that a variable number tandem repeat (VNTR) polymorphism in intron 2 of the interleukin-1 receptor antagonist (IL-1RA) gene might be associated with some chronic inflammatory diseases, autoimmune diseases and solid tumours. To study the distribution of this polymorphism in China, 1352 samples were collected from 19 widely distributed Chinese populations. PCR was used to genotype the VNTR. The overall frequencies of allele 1 and allele 2 were 0.913 and 0.064 respectively. The frequency of the allele 2 was significantly different between the northeastern and the northwestern populations. Moreover, the allele frequencies at this locus in three Chinese Han populations were different from that in minority populations. When compared with other populations worldwide, the...

Toll-like receptors 2 and 4 gene polymorphisms in a southeastern Chinese population with tuberculosis

International Journal of Immunogenetics — Thu, 03 Dec 2009 00:00:00 +0100

Polymorphisms of the toll-like receptor 2 (TLR2) gene (Arg677Trp, Arg753Gln) and the TLR4 gene (Asp299Gly, Thr399Ile) were investigated in 205 tuberculosis (TB) patients and 203 controls. Genetic variations were analysed by DNA sequencing. We revealed that these polymorphisms were rare in the southeastern Chinese population and were not associated with susceptibility to TB. (Source: International Journal of Immunogenetics)

Association of IL-1 gene complex members with ankylosing spondylitis in Chinese Han population

International Journal of Immunogenetics — Tue, 24 Nov 2009 00:00:00 +0100

There are reports of IL-1 complex gene polymorphisms in ankylosing spondylitis (AS; MIM 106300), but the results have been inconsistent among populations. Moreover, few studies examine the association between IL-1 complex gene polymorphisms and clinical symptoms of AS patients. We investigated polymorphisms of IL-1 complex with AS in the Chinese Han population in this study. Chinese Han AS patients and ethnically matched healthy controls were genotyped for five single nucleotide polymorphisms (IL1[beta]+3953, [beta]-511, F10.3, RN.4, RN.6/1) and the IL1RN.VNTR of IL-1 gene cluster. Allele, Genotype and haplotype frequencies were compared between cases and controls by SHEsis software. The frequency of allele C of the marker IL1F10.3 was significantly increased in AS patients versus controls...

Functional polymorphism of cytotoxic T-lymphocyte antigen 4 and nasopharyngeal carcinoma susceptibility in a Chinese population

International Journal of Immunogenetics — Tue, 17 Nov 2009 00:00:00 +0100

In this study, we performed a case[ndash]control study in a Chinese population. Our result showed that the CTLA-4 +49 A>G polymorphism is associated with NPC susceptibility. The subjects carrying the CTLA-4 +49 AA genotype have a [sim]1.8-fold increased risk of NPC (adjust OR 1.83; 95% CI, 1.16[ndash]2.93) when compared with the GG genotype. (Source: International Journal of Immunogenetics)

Nomenclature for factors of the HLA system, update September 2009*

International Journal of Immunogenetics — Thu, 12 Nov 2009 00:00:00 +0100

(Source: International Journal of Immunogenetics)

Nomenclature for factors of the HLA system, update July 2009*

International Journal of Immunogenetics — Mon, 09 Nov 2009 00:00:00 +0100

(Source: International Journal of Immunogenetics)

Nomenclature for factors of the HLA system, update August 2009*

International Journal of Immunogenetics — Mon, 09 Nov 2009 00:00:00 +0100

(Source: International Journal of Immunogenetics)

Molecular analysis of HumDN1 VNTR polymorphism of the human deoxyribonuclease I in systemic lupus erythematosus

International Journal of Immunogenetics — Wed, 28 Oct 2009 00:00:00 +0100

We report a significant association of HumDN1 VNTR polymorphism in DNASE1 gene with SLE. Further functional assays needed to assess the effect of this VNTR on DNASE1 activity and its association with SLE. (Source: International Journal of Immunogenetics)

HLA-G 3'-UTR SNP and 14-bp deletion polymorphisms in Portuguese and Guinea-Bissau populations

International Journal of Immunogenetics — Sun, 11 Oct 2009 23:00:00 +0100

In the HLA-G locus, the 3'-untranslated region (3'-UTR) begins in the mid exon 6, and ends in exon 8. The occurrence of a 14-bp deletion within exon 8, the only mutation known until now in the 3'-UTR, has been considered a risk factor for disease and allograft rejection. To describe the polymorphism within this region, direct sequencing analysis was performed on 120 DNA samples from Portugal and Guinea-Bissau. Results indicate that exon 8 is less conserved than the coding exons. Nine single nucleotide polymorphisms and the previously described 14-bp deletion were found within exon 8 of both populations. Molecular diversity was higher in the Guinean samples than in the Portuguese; however, little differentiation was found among the populations, suggesting that local selection on exon 8 sequ...

Associations of the IL-1 and TNF gene polymorphisms in the susceptibility to duodenal ulcer disease in Chinese Han population

International Journal of Immunogenetics — Sun, 04 Oct 2009 23:00:00 +0100

Our aim was to investigate whether genetic polymorphism of IL-1[Beta]-511, IL-1RN, TNF-A-308 are involved in the susceptibility to duodenal ulcer (DU). 437 unrelated Chinese Han patients with DU and 148 healthy controls were genotyped by the polymerase chain reaction-restriction fragment length polymorphism method for the IL-1B-511, TNF-A-308 gene polymorphisms and the VNTR polymorphism in intron 2 of the IL-1RN gene polymorphisms. There was no difference in the genetic polymorphism of IL-1[Beta]-511, IL-1RN and TNF-A-308 in the patients with DU compared with control. After stratified by Helicobacter pylori infection, they also could not reach significant differences in this study. No statistically significant differences were observed in DU group compared with control according to combina...

Oct-1 is responsible for the C-33T polymorphism effect in the IL-4 promoter

International Journal of Immunogenetics — Sun, 04 Oct 2009 23:00:00 +0100

IL-4 is a pleiotropic immunoregulatory cytokine secreted by Th2 subset of CD4+ Th cells. Several transcription factors (TFs) have been determined with various degrees of certainty to bind the IL-4 promoter and to regulate its expression in human. To investigate the mechanisms responsible for phenotypic effects of the C-33T IL-4 promoter polymorphism, we performed a search of TFs binding to this promoter locus and discriminating the [minus]33C and [minus]33T alleles. In silico searches suggest few factors bind this region. Using an electromobility shift assay we found that Jurkat T cells contained proteins which specifically interacted with oligonucleotide probes, corresponding to the [minus]33 region. Considerable binding differences between C and T alleles were demonstrated using competit...

A novel Y331X nonsense mutation in TNFRSF1A gene in two unrelated Turkish families with periodic fever syndrome

International Journal of Immunogenetics — Sun, 04 Oct 2009 23:00:00 +0100

In conclusion, in Turkish patients, with dominantly inherited recurrent fever, TRAPS is a diagnosis worthy of attention and novel mutations have to be reported with phenotype associations. (Source: International Journal of Immunogenetics)

Genetic variation in CXCL12 and risk of cervical carcinoma: a population-based case–control study

International Journal of Immunogenetics — Thu, 24 Sep 2009 23:00:00 +0100

CXCL12 provides a chemotactic signal-directing leucocyte migration and regulates metastatic behaviour of tumour cells. We conducted a population-based case[ndash]control study to test the hypothesis that common genetic variation in CXCL12 individual single nucleotide polymorphism (SNP) alleles and haplotypes] is associated with the risk of cervical carcinoma. Cases (n = 917) were residents of western Washington State diagnosed with invasive squamous cell cervical carcinoma (SCC), invasive adenocarcinoma or adenosquamous carcinoma, or adenocarcinoma in situ of the cervix. Control participants (n = 849) were identified from the source population by random digit telephone dialling and frequency matched to cases on county and age. Nine CXCL12 tagSNPs chosen from the SeattleSNPs database were g...

A unique display of toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms in non-Han Chinese Hani population

International Journal of Immunogenetics — Wed, 16 Sep 2009 23:00:00 +0100

The toll-like receptor 4 (TLR4) polymorphisms, Asp299Gly and Thr399Ile, were investigated with PCR-RFLP and DNA sequencing methods in 938 and 980 individuals from the Yunnan Hani ethnic minority and the majority Han population, respectively. Six heterozygotes for both Asp299Gly and Thr399Ile were detected in the Hani, a polymorphism frequency of 0.6397%, whereas no variants were found amongst the Han. (Source: International Journal of Immunogenetics)

Detection of a rare Caucasoid HLA-DRB1*0337 in a Taiwanese bone marrow donor using sequence-based typing method

International Journal of Immunogenetics — Wed, 16 Sep 2009 23:00:00 +0100

We here describe the identification of HLA-DRB1*0337, using sequence-based typing (SBT) method, in a Taiwanese bone marrow donor intrigued by a casual curiosity on the donor's racial background. On high-resolution sequence-specific primer (SSP) typing we observed misleading reaction patterns due to similarity of DNA sequences in the exon 2 of DRB1*0301, *0317, *0337 and *1139. When encountering rare alleles in HLA typing, it is important to pay extra attentions to avoid pitfalls and shortcomings of SSP typing kits routinely used and bear in mind that constant up-dating of high-resolution SSP typing kits to be able to distinguish newly reported alleles. SBT may be considered as a back-up HLA typing method to confirm rare alleles. (Source: International Journal of Immunogenetics)

Plasma carnitine ester profiles in Crohn's disease and ulcerative colitis patients with different IGR2230a_1 genotypes

International Journal of Immunogenetics — Mon, 07 Sep 2009 23:00:00 +0100

An association has been repeatedly demonstrated between inflammatory bowel disease (IBD) and the IBD5 locus in the 5q31 chromosomal region. The aim of the present study was to examine the prevalence of the IGR2230a_1 intronic nucleotide polymorphism of the slc22a5 gene (coding for the OCTN2 carnitine transporter protein) lying within this region, and its possible relationship with the carnitine metabolism in Hungarian IBD patients and controls. We genotyped by restriction fragment length polymorphism 200 Crohn's disease (CD) and 246 ulcerative colitis (UC) patients, as well as 187 healthy controls. From plasma samples we determined detailed carnitine ester profiles of 76 CD, 43 UC patients and 45 control persons using electrospray ionization triple quadruple tandem mass spectrometry. The d...

Analysis of the complete genomic sequence of HLA-A alleles in the Chinese Han population

International Journal of Immunogenetics — Sun, 06 Sep 2009 23:00:00 +0100

In this study, complete genomic sequences of common HLA-A alleles were obtained and the data will help us understand the evolution of HLA-A. (Source: International Journal of Immunogenetics)

A novel HLA-B allele, B*5214, detected in a Taiwanese volunteer bone marrow donor using a sequence-based typing method

International Journal of Immunogenetics — Thu, 03 Sep 2009 23:00:00 +0100

HLA-B*5214, a novel rare allele of HLA-B*52 variant, was found in a Taiwanese volunteer bone marrow donor by sequence-based typing method. The sequence of B*5214 is identical to that of B*520101 in exon 2 but differs from B*520101 in exon 3 at nucleotide positions 419 A[rarr]T and 435 A[rarr]G. Alteration of these two nucleotides resulted an amino acid substitution at amino acid residue 116 Y[rarr]F ( TAC[rarr]TTC) and a silent exchange at residue 121 K[rarr]K (AAA[rarr]AAG). (Source: International Journal of Immunogenetics)

Gene polymorphism in transforming growth factor-beta codon 10 is associated with susceptibility to Giardiasis

International Journal of Immunogenetics — Mon, 24 Aug 2009 23:00:00 +0100

Secretory immunoglobulin A (S-IgA) antibodies have a central role in anti-Giardial defence. It has been demonstrated that transforming growth factor-beta1 (TGF-[beta]1) stimulates B lymphocytes to produce and secrete S-IgA. We sought to determine the association between TGF-[beta]1 polymorphism (T+869C) with susceptibility to Giardiasis. The TGF-[beta]1 genotypes and levels of salivary (S-IgA) were analysed in individuals with Giardiasis (97 symptomatic and 57 asymptomatic) and controls (n = 92). Individuals with symptomatic Giardiasis had the lowest levels of S-IgA compared to individuals in asymptomatic Giardiasis and control groups (97%, 73% and 43%, (Source: International Journal of Immunogenetics)

HLA allele and haplotype frequencies in the Albanian population and their relationship with the other European populations

International Journal of Immunogenetics — Sun, 23 Aug 2009 23:00:00 +0100

Human leucocyte antigen (HLA) alleles are very interesting markers in identifying population relationships. Moreover, their frequency distribution data are important in the implementation of donor[ndash]recipient registry programs for transplantation purposes and also in determining the genetic predisposition for many diseases. For these reasons, we studied the HLA class I and II allele and haplotype frequencies in 160 healthy, unrelated Albanian individuals originating from all regions of the country. The HLA genotyping was performed through a 2-digit resolution SSOP method. The data were analysed with Arlequin and Phylip programs. No deviation was found from the Hardy[ndash]Weinberg equilibrium. A total of 17 A*, 30 B*, 12 Cw*, 13 DRB1* and 5 DQB1* alleles were identified. The six most f...

Structural polymorphism of the mannose-binding lectin 2 (MBL2 ) gene in HCV-infected patients with a serological marker for thyroid autoimmunity

International Journal of Immunogenetics — Sun, 23 Aug 2009 23:00:00 +0100

We studied the association of the mannose-binding lectin-2 (MBL2) polymorphism with anti-thyroid antibodies (ATA) in hepatitis C virus (HCV)-infected Brazilian patients (n = 162) and 124 healthy volunteers screened for ATA. Our results showed that patients with ATA had higher frequency of genotype 00 than controls. MBL may play a role as disease modifier in HCV infection. (Source: International Journal of Immunogenetics)

Confirmation of allele HLA-A*3116 found in a family of a leukaemia patient with Caucasian and Caribbean origin

International Journal of Immunogenetics — Sun, 23 Aug 2009 23:00:00 +0100

We confirm allele HLA-A*3116 that we found in the family of a leukaemia patient of mixed Caucasian and Caribbean origin by sequence based typing. This allele is closest related to HLA-A*310102 with one nucleotide replacement at position 221 (C>T) leading to an amino acid substitution at position 50 of the mature protein from proline to leucine. As the amino acid at position 50 in the alpha 1 domain is part of the peptide-binding region, this change could be relevant for the functionality in peptide presentation. (Source: International Journal of Immunogenetics)

Analysis of high-resolution HLA-A, -B, -Cw, -DRB1, and -DQB1 alleles and haplotypes in 718 Chinese marrow donors based on donor–recipient confirmatory typings

International Journal of Immunogenetics — Mon, 10 Aug 2009 23:00:00 +0100

High-resolution human leucocyte antigen (HLA)-A, -B, -Cw, -DRB1, and -DQB1 alleles and haplotype frequencies were analysed from 718 Chinese healthy donors selected from the Chinese Marrow Donor Program registry based on HLA donor[ndash]recipient confirmatory typings. A total of 28 HLA-A, 61 HLA-B, 30 HLA-Cw, 40 HLA-DRB1 and 18 HLA-DQB1 alleles were identified, and HLA-A*1101, A*2402, A*0201, B*4001, Cw*0702, Cw*0102, Cw*0304, DRB1*0901, DRB1*1501, DQB1*0301, DQB1*0303 and DQB1*0601 were found with frequencies higher than 10% in this study population. Multiple-locus haplotype analysis by the maximum-likelihood method revealed 45 A[ndash]B, 38 Cw[ndash]B, 47 B[ndash]DRB1, 29 DRB1[ndash]DQB1, 24 A[ndash]B[ndash]DRB1, 38 A[ndash]Cw[ndash]B, 23 A[ndash]Cw[ndash]B[ndash]DRB1, 33 Cw[ndash]B[ndash...

Nomenclature for factors of the HLA system, June 2009 update*

International Journal of Immunogenetics — Tue, 28 Jul 2009 23:00:00 +0100

(Source: International Journal of Immunogenetics)

MHC microsatellites in a Southern Brazilian population

International Journal of Immunogenetics — Tue, 28 Jul 2009 23:00:00 +0100

This study contributes with important information on HLA haplotypes, and is potentially useful in resolving cases of low resolution HLA genotyping ambiguities. (Source: International Journal of Immunogenetics)

Nomenclature for factors of the HLA system, April 2009 update*

International Journal of Immunogenetics — Wed, 22 Jul 2009 23:00:00 +0100

(Source: International Journal of Immunogenetics)

Nomenclature for factors of the HLA system, May 2009 update*

International Journal of Immunogenetics — Wed, 22 Jul 2009 23:00:00 +0100

(Source: International Journal of Immunogenetics)

Dominant, non-MHC genetic control of food allergy in an adjuvant-free mouse model

International Journal of Immunogenetics — Wed, 15 Jul 2009 23:00:00 +0100

Food allergy is a potentially fatal immune-mediated disorder with incompletely understood mechanisms. We studied the genetic control of food allergy using major histocompatibility complex-identical mice (H2s) and an adjuvant-free method of sensitization. Whereas, transdermal exposure to hazelnut [mdash] a model allergenic food, elicited robust IgG1 response in both strains, an IgE response was evident only in A.SW mice. Following oral challenge, only A.SW but not SJL mice exhibited signs of systemic anaphylaxis and hypothermia. In addition, (A.SW × SJL) F1 hybrids exhibited IgE responsiveness, systemic anaphylaxis and hypothermia similar to A.SW, indicating dominant inheritance of these traits. Furthermore, whereas A.SW and F1 mice but not SJL elicited robust interleukin (IL)-4 response, ...

Association between a common IL10 distal promoter haplotype and IgE production in individuals with atopic dermatitis

International Journal of Immunogenetics — Wed, 24 Jun 2009 23:00:00 +0100

This study is the first to analyse the association between haplotype groups in the IL10 promoter region and clinical phenotypes in AD. We have demonstrated a significant association between the TSS-distal haplotype TGAC, and IgE levels in AD patients. It remains to be shown if there is an association between the TGAC haplotype and IL10 production, which might account for the stimulation of IgE production. (Source: International Journal of Immunogenetics)

The influence of class II transactivator and interleukin-6 polymorphisms on the production of antibodies to donor human leucocyte antigen mismatches in renal allograft recipients

International Journal of Immunogenetics — Wed, 10 Jun 2009 23:00:00 +0100

The influence of polymorphisms in the CIITA and IL-6 genes on donor-specific human leucocyte antigen antibody production was investigated in a cohort of renal transplant recipients and their donors. CIITA and IL-6 single nucleotide polymorphisms were found to be associated with donor-specific human leucocyte antigen antibody production post-transplantation. (Source: International Journal of Immunogenetics)

Sequence-based characterization of swine leucocyte antigen alleles in commercially available porcine cell lines

International Journal of Immunogenetics — Tue, 09 Jun 2009 04:00:00 +0100

A total of 53 alleles at five highly polymorphic swine leucocyte antigen (SLA) loci (SLA-1, SLA-3, SLA-2, SLA-DRB1, and SLA-DQB1) were identified in eight commercially available porcine cell lines (ESK-4, LLC-PK1, MPK, PK13, PK15, PT-K75, SK-RST, and ST). This information is essential for the use of these cell lines to understand the role of SLA genes and proteins in swine models of transplantation, xenotransplantation, and in swine immune responses to infectious diseases and vaccines. The ready availability of these cell lines also makes them a good source of reference DNA for SLA allele typing. (Source: International Journal of Immunogenetics)

Nomenclature for factors of the HLA system, January 2009 update*

International Journal of Immunogenetics — Tue, 26 May 2009 04:00:00 +0100

(Source: International Journal of Immunogenetics)

Nomenclature for factors of the HLA system, February 2009 update*

International Journal of Immunogenetics — Tue, 26 May 2009 04:00:00 +0100

(Source: International Journal of Immunogenetics)

Nomenclature for factors of the HLA system, March 2009 update*

International Journal of Immunogenetics — Tue, 26 May 2009 04:00:00 +0100

(Source: International Journal of Immunogenetics)

MHC class 2 deficiency and X-linked agammaglobulinaemia in a consanguineous extended family

International Journal of Immunogenetics — Tue, 19 May 2009 04:00:00 +0100

We report a consanguineous extended family where four patients have immunodeficiency, three have X-linked agammaglobulinaemia and one has major histocompatibility complex class 2 deficiency. Within one family, two rare genetic diseases with similar clinical manifestations can occur. (Source: International Journal of Immunogenetics)

Genetic susceptibility to haemorrhagic fever with renal syndrome caused by Hantaan virus in Chinese Han population

International Journal of Immunogenetics — Tue, 19 May 2009 04:00:00 +0100

We report a significantly higher occurrence of HLA-DRB1*09 (51% vs. 23%, P = 0.002, OR = 3.57) and HLA-B*46-DRB1*09 (26% vs. 8%, P = 0.018, OR = 3.76) in patients with haemorrhagic fever with renal syndrome (HFRS) compared to the control group, suggesting Hantaan virus-induced HFRS is associated with a genetic predisposition in the Chinese Han population. (Source: International Journal of Immunogenetics)

Detection of a novel HLA-B27 allele, B*2740, in Taiwanese volunteer bone marrow donors by sequence-based typing: curiosity rewarded

International Journal of Immunogenetics — Tue, 19 May 2009 04:00:00 +0100

We report here a novel HLA-B allele, B*2740, discovered in Taiwanese volunteer marrow donors. The new sequence has nucleotide variation at position 527 (T[rarr]A) as compared to B*2708. The nucleotide change caused an amino acid substitution from valine (V) to glutamic acid (E) at codon 152. Since B*2740 carries sequence confers to HLA-Bw6 public epitope we believe that this novel B*27 allele might have been generated from a gene conversion involving a Bw4-specific allele (probably B*2704) and a Bw6-specific allele. (Source: International Journal of Immunogenetics)

The role of the CCR5 Δ32 polymorphism in abdominal aortic aneurysms

International Journal of Immunogenetics — Tue, 19 May 2009 04:00:00 +0100

Conclusion This study demonstrates that the ccr5 [Delta]32 is a biologically active genetic polymorphism; however, there is no association between this polymorphism and AAA. (Source: International Journal of Immunogenetics)

Nomenclature for factors of the HLA system, December 2008 update*

International Journal of Immunogenetics — Fri, 10 Apr 2009 04:00:00 +0100

(Source: International Journal of Immunogenetics)

Haplotype analysis of HLA-A, -B antigens and -DRB1 alleles in south Indian HIV-1-infected patients with and without pulmonary tuberculosis

International Journal of Immunogenetics — Thu, 09 Apr 2009 04:00:00 +0100

We have shown earlier the association of human leucocyte antigen (HLA)-A11 with resistance and HLA-B40 and -DR2 with susceptibility to HIV and HIV-TB. In the present study, we have attempted to find out the HLA-DR2 subtypes and the possible HLA-A/-B/-DRB1 haplotype combinations that are associated with susceptibility or resistance to HIV and HIV with pulmonary tuberculosis (HIV+PTB+). HLA-DR2 subtyping was carried out by polymerase chain reaction-based sequence-specific oligonucleotide probe method. Overrepresentation of HLA-DRB1*1501 in HIV-positive PTB-negative (HIV+PTB[ndash]) patients (P = 0.004, Pc = 0.06) and -DRB1*1502 in HIV-positive PTB-positive (HIV+PTB+) patients (P = 0.019) was observed as compared to healthy controls. Haplotype analysis revealed an increased frequency of HLA-A...

The combination of polymorphisms within MCP-1 and IL-1β associated with ulcerative colitis

International Journal of Immunogenetics — Thu, 09 Apr 2009 04:00:00 +0100

Monocyte chemoattractant protein-1 (MCP-1) is a chemokine involved in monocyte recruitment to sites of inflammation. Raised level of MCP-1 has been widely demonstrated in the intestinal mucosa of patients with ulcerative colitis (UC), suggesting an important role of MCP-1 in the pathogenesis of UC. The [ndash]2518A/G polymorphism in the promoter region of MCP-1 gene affecting its transcriptional activation has been reported recently. In order to assess the potential role of this polymorphism in UC, we examined its distribution in 162 unrelated UC patients and 203 healthy controls. In addition, considering the gene regulatory association between interleukin-1[beta] (IL-1[beta]) and MCP-1, we further examined whether the gene polymorphisms between MCP-1 and IL-1[beta] exert synergetic effect...

Decreased T-cell receptor excision DNA circles in peripheral blood mononuclear cells among benzene-exposed workers

International Journal of Immunogenetics — Fri, 20 Feb 2009 05:00:00 +0100

In conclusion, the recent thymic output function and the T-cell immune function were apparently impaired in workers after benzene exposure. (Source: International Journal of Immunogenetics)

Nomenclature for factors of the HLA system, November 2008 update*

International Journal of Immunogenetics — Wed, 18 Feb 2009 05:00:00 +0100

(Source: International Journal of Immunogenetics)

Identification of a novel HLA-A allele, A*1131, in a Taiwanese

International Journal of Immunogenetics — Wed, 18 Feb 2009 05:00:00 +0100

Here we report the identification and sequence analysis of a new HLA-A11* variant, A*1131 allele, found in a Taiwanese volunteer bone marrow donor. The novel A*11 variant is identical to A*1125 in exon 2 but differs from A*1125 in exon 3 by one nucleotide substitution at position 527 causing an amino acid change at codon 152 E[rarr]V (GAG[rarr]GTG). In comparison with HLA-A*110101, allele A*1131 has three nucleotide differences in exon 3: 527 C[rarr]T, 538 C[rarr]T and 539 A[rarr]T leading to two amino acid variations at residues 152 A[rarr]V and 156 Q[rarr]L. (Source: International Journal of Immunogenetics)

Molecular cloning and expression analysis of the pig small ubiquitin-like modifier (SUMO) gene family

International Journal of Immunogenetics — Wed, 07 Jan 2009 04:19:14 +0100

In this study, we have cloned cDNA encoding for three different pig SUMO isoforms. The full-length cDNA encoding for pig Sumo1, Sumo2 and Sumo4 consists of 306, 288 and 288 nucleotide base pairs of the open reading frame, respectively, and the putative amino acid sequences of pig Sumo1, Sumo2 and Sumo4 are composed of 101, 95 and 95 peptides, respectively. The structures of pig SUMOs are evolutionally well conserved, and their expression has been detected in a broad range of tissues. We also determined that all pig SUMOs are localized within the nucleus. However, the different tissue expression observed in individual pig SUMOs may show the divergent or specialized role of each of the pig SUMO isoforms. Future studies will focus on the identification of targets for sumoylation by different ...

A comparative analysis of the products of GROEL-1 gene from Chlamydia trachomatis serovar D and the HSP60 var1 transcript from Homo sapiens suggests a possible autoimmune response

International Journal of Immunogenetics — Wed, 10 Dec 2008 05:00:00 +0100

Chlamydia trachomatis serovar D produces large quantities of HSP60-1 during infections, which accumulate inside the host cell inducing autoimmunity. We compare the aminoacid sequences of the human HSP60 with the bacterial counterpart to better elucidate how CTHSP60 may simulate HSP60 from human origin during infection and may induce an autoimmune response. As a result of the comparison we suggest several possible epitopes of the CTHSP60, which may induce autoimmunity. (Source: International Journal of Immunogenetics)

Nomenclature for factors of the HLA system, September 2008 update*

International Journal of Immunogenetics — Wed, 03 Dec 2008 05:00:00 +0100

(Source: International Journal of Immunogenetics)

The non-inherited maternal HLA haplotype affects the risk for type 1 diabetes

International Journal of Immunogenetics — Mon, 01 Dec 2008 05:00:00 +0100

The aim was to test the hypothesis that the human leucocyte antigen (HLA) haplotype that is not inherited from the mother, that is, the non-inherited maternal antigen (NIMA) affects the risk for type 1 diabetes (T1D). A total of 563 children with T1D and 286 non-diabetic control children from Sweden were genotyped for DRB1, DQA1 and DQB1 alleles. The frequency of positively (DR4-DQA1*0301-B1*0302 and DR3-DQA1*0501-B1*0201), negatively (DR15-DQ A1*0102-B1*0602) or neutrally (all other) T1D associated HLA haplotypes were compared between NIMA and non-inherited paternal antigen (NIPA). All comparisons were carried out between HLA-matched patients and controls. The frequency of positively associated NIMA was higher among both DR4/X-positive healthy individuals compared wit DR4/X-positive patie...

Identification of new variants within the two functional genes CCL3 and CCL3L encoding the CCL3 (MIP-1α) chemokine: implications for HIV-1 infection

International Journal of Immunogenetics — Mon, 01 Dec 2008 05:00:00 +0100

The CC chemokine CCL3 is encoded by two functional genes, namely CCL3 and CCL3L, and has been identified as a key chemokine in HIV-1 susceptibility and disease progression. The complete CCL3 and CCL3L genes and core promoters of 43 African mother[ndash]infant pairs (86 samples) and 28 Caucasian adults in South Africa were sequenced and extensively analysed for genetic variations. Africans were found to be more polymorphic in both genes with 25 single nucleotide polymorphisms (SNPs) in the CCL3 gene and 14 gene copy number single nucleotide polymorphisms (gcnSNPs) in the CCL3L gene, compared to nine CCL3 SNPs and eight CCL3L gcnSNPs in Caucasians. A total of 14 polymorphisms across the two genes were newly identified in this study, most (12/14) of which were exclusive to the African populat...

The peopling of Madeira archipelago (Portugal) according to HLA genes

International Journal of Immunogenetics — Mon, 01 Dec 2008 05:00:00 +0100

The Madeira-Porto Santo Archipelago was officially colonized in 1420 by Portuguese settlers. Its importance in Columbus' information for the American discovery and for slave traffic across the Atlantic is unquestionable. Thus, a complex peopling may have given rise to a present-day high admixture of ethnicities according to HLA genes. A sample of 173 healthy unrelated Madeirans was analysed and compared with 6986 HLA chromosomes from other worldwide populations. Genetic distances, neighbour-joining dendrograms and correspondence analyses were used for comparisons. Southern European, North African (including Canary Islands), Jewish and Mediterranean typical HLA alleles were found and genetic distances from Madeirans to these populations were the closest ones. In addition A*24-B*65-DRB1*0102...

NRAMP1 (SLC11A1) gene polymorphisms that correlate with autoimmune versus infectious disease susceptibility in tuberculosis and rheumatoid arthritis

International Journal of Immunogenetics — Mon, 01 Dec 2008 05:00:00 +0100

NRAMP1 gene has multiple pleiotropic effects on macrophage activation pathways. These pleiotropic effects may increase resistance to infections such as tuberculosis (TB), but may also lead to susceptibility of autoimmune diseases such as rheumatoid arthritis (RA). It has been hypothesized that allele 3 would be associated with autoimmune diseases, whereas allele 2 would be associated with infectious diseases, and genetic factors that enhanced survival in the epidemics of TB might have led to susceptibility for the development of RA. We analysed four NRAMP1 gene polymorphisms including 5' promoter (GT)n (rs34448891), INT4 (469 + 14G/C) (rs3731865), 3'UTR (1729 + 55del4) (rs17235416) and D543N (codon 543, Asp to Asn) (rs17235409) in 112 patients with TB, 98 patients with RA, 80 healthy contr...

MCP-1 and CCR2 gene polymorphisms in Czech patients with allergic disorders

International Journal of Immunogenetics — Mon, 01 Dec 2008 05:00:00 +0100

Several lines of evidence suggest that chemokines play an important role in asthma and allergy. We analysed polymorphisms at [ndash]2518A/G and [ndash]2076A/T of MCP-1 and V64I of CCR2 gene in healthy subjects (n = 306) and allergic patients (n = 332). Allele and genotype frequencies did not differ significantly between groups. Nevertheless, MCP-1 variants were associated with allergen sensitization. The results suggest that MCP-1, but not CCR2 gene variants, may participate in the pathogenesis of allergic phenotypes at least in the Caucasian population. (Source: International Journal of Immunogenetics)

Analysis of ERCC2/XPD functional polymorphisms in systemic lupus erythematosus

International Journal of Immunogenetics — Mon, 01 Dec 2008 05:00:00 +0100

In conclusion, the ERCC2/XPD functional polymorphisms analysed in this study showed no association in genetic susceptibility to SLE. (Source: International Journal of Immunogenetics)

CRP and FCGR2A genes have an epistatic effect on carotid artery intima-media thickness: the Cardiovascular Risk in Young Finns Study

International Journal of Immunogenetics — Mon, 01 Dec 2008 05:00:00 +0100

In conclusion, this study showed that the effect of CRP genetics on early atherosclerotic changes is modulated by the FCGR2A genetics. (Source: International Journal of Immunogenetics)

Nomenclature for factors of the HLA system, August 2008 update*

International Journal of Immunogenetics — Mon, 01 Dec 2008 05:00:00 +0100

(Source: International Journal of Immunogenetics)

Nomenclature for factors of the HLA system, July 2008 update*

International Journal of Immunogenetics — Mon, 01 Dec 2008 05:00:00 +0100

(Source: International Journal of Immunogenetics)

Unusual amplification pattern by SSP HLA-B typing led to discovery of a novel HLA-C allele

International Journal of Immunogenetics — Thu, 09 Oct 2008 04:00:00 +0100

We report here the unique sequence of a novel human leucocyte antigen (HLA)-C allele resulted in amplification of a product with a primer pair used in sequence-specific primer (SSP) HLA-B typing, which led subsequently to identification of a new allele of Cw*0339 by sequence-based typing method. This new allele is closely related to Cw*031101 with only two nucleotide changes from T to G at position 97, and T to C at position 105 in the exon 2 region of HLA-C locus. The first nucleotide substitution causes an amino acid alteration from tyrosine to aspartic acid at amino acid residue 9 (Y to D), while the second one keeps alanine at residue 11 unchanged. Most interestingly, the nucleotide change from T to G at position 97 makes it identical to the 3' end sequence of one SSP of the commercial...

The G/G genotype of transforming growth factor beta 1 (TGF-β1) single nucleotide (+915G/C) polymorphism coincident with other host and environmental factors is associated with irreversible bronchoconstriction in asthmatics

International Journal of Immunogenetics — Wed, 08 Oct 2008 04:00:00 +0100

Irreversible airflow obstruction may develop in some cases of asthma even in absence of known risk factors such as smoking and environmental insults and despite implementing apparently appropriate therapy. This implies that genetic factors may significantly contribute to determining the severity in the course of the disease. The published reports on genetic predisposition to irreversible bronchoconstriction in asthma, however, are relatively scarce, and disregard its potential association with transforming growth factor (TGF)-[beta]1 gene polymorphism despite established role that TGF-[beta]1 plays in airway remodelling. We tested TGF-[beta]1 single-nucleotide polymorphisms (SNPs) at position +869 of codon 10 (leucine or proline) and position +915 of codon 25 (arginine or proline) for asso...

HLA haplotypes in recurrent aphthous stomatitis: a mode of inheritance?

International Journal of Immunogenetics — Wed, 08 Oct 2008 04:00:00 +0100

The aim of this study was to investigate the genetic association between recurrent aphthous stomatitis (RAS) and human leucocyte antigen (HLA) class I and II alleles and HLA haplotypes. Families selected had at least one child suffering from recurrent aphthous stomatitis in addition to one or both of the parents. HLA-A, -B and -DR alleles were typed in 29 families, 27 nuclear and two extended (121 subjects). HLA haplotypes of all family members with RAS were compared with those who were RAS negative. Although major histocompatibility complex class I and II gene analysis failed to demonstrate any significant association between RAS and HLA antigens, the study of HLA haplotypes revealed a significant association between HLA haplotypes and susceptibility to RAS. The results indicate that susc...

Combination of KIR 2DL2 and HLA-C1 (Asn80) confers susceptibility to type 1 diabetes in Latvians

International Journal of Immunogenetics — Wed, 08 Oct 2008 04:00:00 +0100

Killer immunoglobulin-like receptors (KIRs) are known to modulate natural killer (NK) and NK T-cell function by interacting with human leucocyte antigen (HLA) class I ligands on target cells. The aim of our study was to investigate the influence of KIR2D genes with their HLA-C ligands in susceptibility to type 1 diabetes. A total of 98 type 1 diabetes patients and 70 healthy subjects from Latvia were typed for KIR genes and HLA-C ligands using polymerase chain reaction-based genotyping. The HLA C1+/C2+ combination was positively, and C1[ndash]/C2+ combination was negatively, associated with type 1 diabetes. Stratification analysis of KIR/HLA-C ligand combinations showed 2DL2+/C1+, 2DL3+/C1+, and 2DS2+ /C1+ to be positively, and 2DL2[ndash]/C1[ndash] and 2DS2[ndash]/ C1[ndash] to be negativ...

DC-SIGN and DC-SIGNR polymorphic variants in Northern Asian Indians

International Journal of Immunogenetics — Wed, 08 Oct 2008 04:00:00 +0100

Dendritic cell-specific intercellular adhesion molecule-grabbing nonintegrin-related protein (DC-SIGNR), along with DC-SIGN, is suggested to facilitate HIV infection of T cells in trans through binding with HIV gp120. We studied the repeat region polymorphisms in DC-SIGN and DC-SIGNR in 100 healthy HIV-1 seronegative individuals among Northern Asian Indians. Each variant polymorphism obtained by polymerase chain reaction (PCR) was confirmed by cloning and sequencing. Fifty-four per cent of the healthy seronegative individuals were homozygous for the DC-SIGNR 7/7 repeat. The heterozygous 7/5 variant was found in 25%, while the 5/5 homozygous genotype was found in 17% of the subjects. Allele 8 was rare and accounted for 4% of the heterozygous genotype (8/7) in the sample population. DC-SIGN ...

HLA antibody testing: a tool to facilitate not to prevent organ transplantation

International Journal of Immunogenetics — Sat, 06 Sep 2008 04:00:00 +0100

The introduction of very sensitive HLA antibody screening assays has destroyed the old dogma that pre-existence of donor specific HLA antibodies in the patient is a contra-indication for transplantation. The challenge is now to reach consensus on the parameters which predict the clinical relevance of donor specific HLA antibodies. Antibody screening assays should not only be used to prevent transplantation of patients with donor specific antibodies but also to facilitate transplantation of highly sensitized patients, both by defining acceptable HLA mismatches and non-detrimental donor specific HLA antibodies. (Source: International Journal of Immunogenetics)

FCER1A gene proximal promoter polymorphisms in Caucasians and East Asians

International Journal of Immunogenetics — Sat, 02 Aug 2008 04:00:00 +0100

Two FCER1A gene proximal promoter polymorphisms, [ndash]344C > T and [ndash]95T > C, both associated with total serum IgE and/or allergic disorders in Caucasians and East Asians, were shown to influence the gene expression in additive manner. In face of the rarity of other proximal promoter variants in Caucasians or their lack in East Asians, future investigations of the FCER1A locus in these ethnic groups should probably focus on three common haplotypes of the common [ndash]344C > T and [ndash]95T > C polymorphisms. (Source: International Journal of Immunogenetics)

TNF, IFNG, IL6, IL10 and TGFB1 gene polymorphisms in South and Southeast Brazil

International Journal of Immunogenetics — Fri, 01 Aug 2008 04:00:00 +0100

This study attempted to establish single nucleotide polymorphism frequencies of TNF, IL6, IFNG, IL10 and TGFB1 genes among healthy individuals from South and Southeast Brazil. The sample included 108 healthy individuals from South and 106 from Southeast Brazil. Polymerase chain reaction using sequence-specific primers genotyping was performed for these gene cytokines with Cytokine Genotyping Primers (One Lambda, Canoga Park, CA, USA). Differences in genotypic and allelic frequencies between the populations were assessed by chi-square with either Yates' correction or Fisher's exact test. Our investigations showed that there were not any significant differences between these two Brazilian populations for these polymorphisms. A statistically significant difference in the distribution of allel...

No association of the CD45 77C>G transversion with inflammatory bowel disease in German patients

International Journal of Immunogenetics — Fri, 01 Aug 2008 04:00:00 +0100

A 77C>G transversion in exon A of the CD45 gene was investigated in patients with inflammatory bowel disease (IBD) and controls. The distribution of the 77G allele was not significantly different between patients and controls. We found no evidence for the contribution of the 77C>G transversion in susceptibility to IBD. (Source: International Journal of Immunogenetics)

The microsatellite, macrophage migration inhibitory factor -794, may influence gene expression in human mononuclear cells stimulated with E. coli or S. pneumoniae

International Journal of Immunogenetics — Fri, 01 Aug 2008 04:00:00 +0100

Polymorphisms within the gene encoding macrophage migration inhibitory factor (MIF) have been associated with susceptibility to inflammatory diseases such as rheumatoid arthritis and increased risk of developing sepsis. We investigated the effects of the MIF-173G>C polymorphism and the MIF-794 CATT microsatellite on MIF expression. These are in moderate linkage disequilibrium. Mononuclear cells from healthy donors were stimulated with bacterial pathogens associated with sepsis (Streptococcus pneumoniae or Escherichia coli). MIF mRNA and protein levels were measured by real-time polymerase chain reaction and ELISA, respectively. Carriage of the C allele of MIF-173G>C or the 7 CATT repeat of the MIF-794 microsatellite correlated with lower basal and stimulated MIF mRNA levels. However, level...

Investigation of CTLA-4 and CD28 gene polymorphisms in a group of Turkish patients with colorectal cancer

International Journal of Immunogenetics — Fri, 01 Aug 2008 04:00:00 +0100

In this study, we aimed to investigate the association of cancer with the frequencies and roles of CTLA-4/+49A > G (exon 1) and [ndash]318C > T (promoter), and CD28/IVS3 + 17T > C (intron 3 position + 17). These polymorphisms were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 218 Turkish subjects (56 patients with CRC and 162 healthy controls). No statistically significant differences in the genotype distributions of CTLA-4/+49GG (1.8% vs. 6.8%, odds ratio (OR) = 0.250, P = 0.305) and CTLA-4/[minus]318TT (0% vs. 0.6%, OR = 1.006, P = 1.000), and CD28/IVS3 + 17CC (8.9% vs. 3.7%, OR = 0.2411, P = 0.155) between patients with CRC and healthy controls, were observed. We also found that there were no significant differences in the frequencies o...

An investigation of the C4 gene arrangement in ethnic Chinese (Taiwanese)

International Journal of Immunogenetics — Fri, 01 Aug 2008 04:00:00 +0100

C4 complement components are encoded by two genes, C4A and C4B, located on chromosome 6p21.3 of the major histocompatibility complex class III region. The isotypic residues at position 1101[ndash]1106 of the C4A gene contain the Pro-Cys-Pro-Val-Leu-Asp sequence which has a higher affinity for binding amino group-containing antigens, while C4B contains the Leu-Ser-Pro-Val-Ileu-His sequence which has a higher affinity for hydroxyl group-containing antigens. These two genes show different reaction rates which infer solubilization of antibody[ndash]antigen aggregates and propagation of the activation pathway to form the membrane attack complex. Using a polymerase chain reaction-based amplification method to identify and differentiate the locations of the C4A and C4B genes adjacent to the respe...

Nomenclature for factors of the HLA system, March 2008 update*

International Journal of Immunogenetics — Fri, 25 Jul 2008 04:00:00 +0100

(Source: International Journal of Immunogenetics)

Sequencing of 15 new BoLA-DRB3 alleles

International Journal of Immunogenetics — Fri, 18 Jul 2008 04:00:00 +0100

The class II DR of bovine major histocompatibility complex of cattle (BoLA) plays a central role in the regulation of the immune response through their ability to present those peptides to T-cell receptors. In this work, we sequenced the exon2 of DRB3 to identify new alleles in Chinese yellow cattle, a total of 15 new BoLA-DRB3 alleles were found. (Source: International Journal of Immunogenetics)

Characterization of tumour necrosis factor-alpha genetic variants and mRNA expression in patients with severe sepsis

International Journal of Immunogenetics — Thu, 17 Jul 2008 04:00:00 +0100

Tumour necrosis factor-alpha (TNF[alpha]) has been implicated in the pathogenicity of severe sepsis by both genetic association studies and animal models. Conflicting functional data have emerged in relation to genetic variants and TNF[alpha] protein production. Therefore, we assessed the functionality of TNF[alpha] genetic variants in terms of mRNA production and their potential influence on outcome in the setting of severe sepsis. Sixty-two Irish Caucasian patients presenting with severe sepsis were recruited and TNF[alpha] mRNA and protein levels were quantified. Patient DNA was analysed for the presence of common promoter polymorphisms and haplotypes were inferred. An A allele at position [ndash]863 was associated with more TNF[alpha] mRNA on day 1 compared to C homozygotes (P = 0.037)...

Nomenclature for factors of the HLA system, December 2007 update*

International Journal of Immunogenetics — Sun, 13 Jul 2008 04:00:00 +0100

(Source: International Journal of Immunogenetics)

Sequence-based characterization of the eight SLA loci in Korean native pigs

International Journal of Immunogenetics — Sat, 28 Jun 2008 04:00:00 +0100

Eight swine leucocyte antigen (SLA) gene (SLA-1, SLA-2, SLA-3, SLA-6, DRA, DRB1, DQA, DQB1) alleles were identified using sequence-based typing method in three Korean native pigs used for breeding at the National Institute of Animal Science in Korea. Six new alleles in class I genes and three new alleles in class II genes have been identified in this breed and can give valuable information for xenotransplantation and disease resistance. (Source: International Journal of Immunogenetics)

New insights into the genetic basis of nasopharyngeal carcinomas

International Journal of Immunogenetics — Sat, 28 Jun 2008 04:00:00 +0100

(Source: International Journal of Immunogenetics)

New insights into the genetic basis of nasopharyngeal carcinomas

International Journal of Immunogenetics — Thu, 12 Jun 2008 18:17:38 +0100

International Journal of Immunogenetics, Volume 0, Issue 0, Page ???, OnlineEarly Articles. (Source: International Journal of Immunogenetics)

Sequence-based characterization of the eight SLA loci in Korean native pigs

International Journal of Immunogenetics — Thu, 12 Jun 2008 07:59:37 +0100

International Journal of Immunogenetics, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Summary Eight swine leucocyte antigen (SLA) gene (SLA-1, SLA-2, SLA-3, SLA-6, DRA, DRB1, DQA, DQB1) alleles were identified using sequence-based typing method in three Korean native pigs used for breeding at the National Institute of Animal Science in ... (Source: International Journal of Immunogenetics)

Nomenclature for factors of the HLA system, March 2008 update*

International Journal of Immunogenetics — Wed, 14 May 2008 18:18:04 +0100

International Journal of Immunogenetics, Volume 0, Issue 0, Page ???, OnlineEarly Articles. (Source: International Journal of Immunogenetics)

Solid phase testing in the HLA laboratory: implications for organ allocation

International Journal of Immunogenetics — Wed, 14 May 2008 00:22:28 +0100

International Journal of Immunogenetics, Volume 0, Issue 0, Page ???, OnlineEarly Articles. (Source: International Journal of Immunogenetics)

Nomenclature for factors of the HLA system, January 2008 update*

International Journal of Immunogenetics — Wed, 14 May 2008 00:22:25 +0100

International Journal of Immunogenetics, Volume 0, Issue 0, Page ???, OnlineEarly Articles. (Source: International Journal of Immunogenetics)

Nomenclature for factors of the HLA system, February 2008 update*

International Journal of Immunogenetics — Wed, 14 May 2008 00:22:23 +0100

International Journal of Immunogenetics, Volume 0, Issue 0, Page ???, OnlineEarly Articles. (Source: International Journal of Immunogenetics)

Genetic affinity of two south Indian ethnic groups with other populations

International Journal of Immunogenetics — Mon, 12 May 2008 05:50:28 +0100

International Journal of Immunogenetics, Volume 35, Issue 3, Page 243-249, June 2008. Summary Humans appear to have spread to several parts of the Indian subcontinent by the middle Paleolithic period. It also provided a major passage for the distribution of modern humans. For the first time generic human leucocyte antigen (HLA) class II (... (Source: International Journal of Immunogenetics)

IJI Reviews: a new Editor

International Journal of Immunogenetics — Mon, 12 May 2008 05:50:20 +0100

International Journal of Immunogenetics, Volume 35, Issue 3, Page 177, June 2008. (Source: International Journal of Immunogenetics)

Evaluation of IL10, IL19 and IL20 gene polymorphisms and chronic hepatitis B infection outcome

International Journal of Immunogenetics — Mon, 12 May 2008 05:50:17 +0100

International Journal of Immunogenetics, Volume 35, Issue 3, Page 255-264, June 2008. Summary Hepatitis B virus (HBV) infection remains a serious global health problem despite the availability of a highly effective vaccine. Approximately 5% of HBV-infected adults develop chronic hepatitis B, which may result in liver cirrhosis or ... (Source: International Journal of Immunogenetics)

Human MHC architecture and evolution: implications for disease association studies

International Journal of Immunogenetics — Tue, 08 Apr 2008 18:37:51 +0100

International Journal of Immunogenetics, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Summary Major histocompatibility complex (MHC) variation is a key determinant of susceptibility and resistance to a large number of infectious, autoimmune and other diseases. Identification of the MHC variants conferring susceptibility to disease is ... (Source: International Journal of Immunogenetics)

Regulatory region polymorphisms of vitamin D receptor gene in pulmonary tuberculosis patients and normal healthy subjects of south india

International Journal of Immunogenetics — Tue, 08 Apr 2008 12:15:54 +0100

International Journal of Immunogenetics, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Summary Vitamin D receptor (VDR) gene variants are associated with differential susceptibility or resistance to tuberculosis in different ethnic groups. We investigated the polymorphisms in the 5' regulatory region of VDR gene in 206 normal healthy ... (Source: International Journal of Immunogenetics)

Interleukin-10 promoter polymorphisms in patients with systemic lupus erythematosus from the Canary Islands

International Journal of Immunogenetics — Tue, 08 Apr 2008 12:15:54 +0100

International Journal of Immunogenetics, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Summary The purpose of this study was to examine whether several allelic variants in the polymorphic interleukin (IL)-10 promoter region were related with an increased risk of developing systemic lupus erythematosus (SLE) in Spanish patients from Canary ... (Source: International Journal of Immunogenetics)

Characterization of a candidate locus for malaria susceptibility in human populations: a (TA)n microsatellite in the promoter region of the CYBB gene, the gp91phox subunit of the NADPH oxidase

International Journal of Immunogenetics — Thu, 06 Mar 2008 06:16:09 +0100

International Journal of Immunogenetics, Volume 35, Issue 2, Page 107-109, April 2008. Summary We have analysed the linkage disequilibrium pattern between the promoter TA microsatellite and Single Nucleotide Polymorphism (SNP) haplotypes for the CYBB gene. None of the CYBB SNPs serve as good surrogates for the microsatellite alleles, ... (Source: International Journal of Immunogenetics)

Association of interleukin-1 receptor antagonist +2018 gene polymorphism with Japanese chronic periodontitis patients using a novel genotyping method

International Journal of Immunogenetics — Thu, 06 Mar 2008 06:14:18 +0100

In this study, we have focused on nine functional gene polymorphisms encoding immunoregulation-related molecules such as cytokines (interleukin-1 (IL-1), ... (Source: International Journal of Immunogenetics)

The frequency of transforming growth factor-β1 gene polymorphisms in a normal southern Iranian population

International Journal of Immunogenetics — Thu, 06 Mar 2008 06:13:30 +0100

International Journal of Immunogenetics, Volume 35, Issue 2, Page 145-151, April 2008. Summary Several single nucleotide polymorphisms (SNPs) of the transforming growth factor-β1 gene (TGFB1) have been reported. Determination of TGFB1 SNPs allele frequencies in different ethnic groups is useful for both population genetic analyses and ... (Source: International Journal of Immunogenetics)

A search for cyclophilin-A gene (PPIA) variation and its contribution to the risk of atherosclerosis and myocardial infarction

International Journal of Immunogenetics — Thu, 06 Mar 2008 06:13:09 +0100

International Journal of Immunogenetics, Volume 35, Issue 2, Page 159-164, April 2008. Summary Cyclophilin A is secreted by vascular smooth muscle cells in response to inflammatory stimuli, and could thus contribute to atherosclerosis. We hypothesized that the genetic variation at the cyclophilin A gene (PPIA) could affect the risk for ... (Source: International Journal of Immunogenetics)

Nomenclature for factors of the HLA system, December 2007 update*

International Journal of Immunogenetics — Thu, 06 Mar 2008 06:12:53 +0100

International Journal of Immunogenetics, Volume 35, Issue 2, Page 175-176, April 2008. (Source: International Journal of Immunogenetics)

Interleukin-10 and interferon-gamma gene polymorphisms in patients with nasopharyngeal carcinoma

International Journal of Immunogenetics — Fri, 29 Feb 2008 19:18:55 +0100

International Journal of Immunogenetics, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Summary Nasopharyngeal carcinoma (NPC) is a multifactorial disease. Cytokines driving the immune response seem to be disturbed in NPC patients. Since interleukin-10 (IL-10) is known to reduce the production of interferon-gamma (IFN-γ), we supposed that ... (Source: International Journal of Immunogenetics)

Characterization, expression and evolution analysis of Toll-like receptor 1 gene in pufferfish (Tetraodon nigroviridis)

International Journal of Immunogenetics — Fri, 29 Feb 2008 10:20:26 +0100

International Journal of Immunogenetics, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Summary The Toll-like receptor (TLR) family is a pathogen-associated molecular pattern recognition receptor family that plays key roles in the activation of innate immune system. As an important member of TLRs, TLR1 is involved in the recognition of ... (Source: International Journal of Immunogenetics)

Characterization of two novel HLA class I alleles: HLA-A310103 and HLA-B9531

International Journal of Immunogenetics — Fri, 29 Feb 2008 10:20:24 +0100

International Journal of Immunogenetics, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Summary Two novel human leucocyte antigen (HLA) class I alleles were characterized by means of sequencing-based typing techniques. HLA-A*310103 was identified in a cord blood unit from a Caucasoid individual. The sequence of this allele is identical to ... (Source: International Journal of Immunogenetics)

Association of vitamin D receptor polymorphisms with the outcome of allogeneic haematopoietic stem cell transplantation

International Journal of Immunogenetics — Fri, 29 Feb 2008 10:20:21 +0100

International Journal of Immunogenetics, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Summary Recently, vitamin D receptor (VDR) polymorphism has been identified as an additional genetic factor associated with the outcome after allogeneic haematopoietic stem cell transplantation (HSCT) from HLA-matched sibling donors. In the present study,... (Source: International Journal of Immunogenetics)

Molecular characterization of toll-like receptor 2 of ruminants and comparative expression in nilgai (Boselaphus tragocamelus) vs. buffalo (Bubalus bubalis)

International Journal of Immunogenetics — Fri, 29 Feb 2008 10:20:13 +0100

International Journal of Immunogenetics, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Summary Toll-like receptors play role in the innate immune responses and orchestrate the adaptive immunity by induction of proinflammatory cytokines and up-regulation of costimulatory molecules. The present study has characterized TLR2 cDNA in nilgai, ... (Source: International Journal of Immunogenetics)

A possible mechanism for non-replication of allelic association between a single nucleotide polymorphism of the human beta T-cell receptor and autoimmune diseases

International Journal of Immunogenetics — Wed, 13 Feb 2008 19:16:39 +0100

International Journal of Immunogenetics, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Summary Gene polymorphisms, in particular single nucleotide polymorphisms (SNPs), have been associated to multifactorial diseases such as cancer, inflammation and autoimmunity. Indeed for some autoimmune diseases, it has been possible to identify ... (Source: International Journal of Immunogenetics)

The genetic differences with whole genome linkage disequilibrium mapping between responder and non-responder in interferon-α and ribavirin combined therapy for chronic hepatitis C patients

International Journal of Immunogenetics — Wed, 13 Feb 2008 06:55:08 +0100

International Journal of Immunogenetics, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Summary Interferon-α and ribavirin combined therapy has been a mainstream treatment for hepatitis C infection. The efficacy of this combined treatment is around 30% to 60%, and the factors affecting the responsiveness are still poorly defined. Our study ... (Source: International Journal of Immunogenetics)

Speed and selection in the evolution of killer-cell immunoglobulin-like receptors

International Journal of Immunogenetics — Wed, 13 Feb 2008 06:55:06 +0100

International Journal of Immunogenetics, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Summary The killer-cell immunoglobulin-like receptors (KIR) form a diverse family of receptors that control the functions of natural killer cells. Sequencing of KIR from primates has revealed the unexpected extent to which this gene family has ... (Source: International Journal of Immunogenetics)

Association of vitamin D receptor gene 3'-variants with Hashimoto's thyroiditis in the Croatian population

International Journal of Immunogenetics — Wed, 13 Feb 2008 06:55:05 +0100

International Journal of Immunogenetics, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Summary Hashimoto's thyroiditis (HT) is the most frequent autoimmune thyroid disease with strong genetic background. Vitamin D receptor (VDR) endocrine system affects immunosuppressive, regulatory and tolerogenic decisions required for induction and ... (Source: International Journal of Immunogenetics)

HLA DRB1, DQB1 and insulin promoter VNTR polymorphisms: interactions and the association with adult-onset diabetes mellitus in Czech patients

International Journal of Immunogenetics — Wed, 13 Feb 2008 06:55:04 +0100

International Journal of Immunogenetics, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Summary Both the human leucocyte antigen (HLA) DRB1 and the HLA DQB1 gene loci play a role in the development and progression of autoimmune diabetes mellitus (T1DM). Similarly, the insulin promoter variable number tandem repeats (INS-VNTR) polymorphism ... (Source: International Journal of Immunogenetics)

The effects of RANTES/CCR5 promoter polymorphisms on HIV disease progression in HIV-infected Koreans

International Journal of Immunogenetics — Fri, 25 Jan 2008 19:57:11 +0100

International Journal of Immunogenetics, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Summary Recent studies have reported that two single nucleotide polymorphisms (SNPs) in the RANTES gene promoter region, –403G/A and –28C/G, are associated with a slower rate of decline in CD4+ T-cell number, whereas genetic polymorphisms within the CCR5 ... (Source: International Journal of Immunogenetics)

Polymorphism of the interleukin-10 gene in polycystic ovary syndrome

International Journal of Immunogenetics — Fri, 25 Jan 2008 06:04:29 +0100

International Journal of Immunogenetics, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Summary Interleukin (IL)-10 is a major anti-inflammatory cytokine that has been associated with obesity and type 2 diabetes. We aimed to evaluate the IL-10 gene polymorphisms in polycystic ovary syndrome (PCOS) and control subjects. Ninety-one young ... (Source: International Journal of Immunogenetics)

The MMP2 rs243865-T allele is not a major genetic factor for rheumatoid arthritis in the French Caucasian population

International Journal of Immunogenetics — Mon, 21 Jan 2008 20:27:31 +0100

International Journal of Immunogenetics, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Summary The MMP2 rs243865-T allele was recently suggested to be associated with rheumatoid arthritis (RA) in a case–control study. MMP2 is a positional RA candidate gene. Our aim was to test rs243865 in a French family based study. No significant result ... (Source: International Journal of Immunogenetics)

Nomenclature for factors of the HLA system, December 2007 update*

International Journal of Immunogenetics — Mon, 21 Jan 2008 05:47:08 +0100

International Journal of Immunogenetics, Volume 0, Issue 0, Page ???, OnlineEarly Articles. (Source: International Journal of Immunogenetics)

Nomenclature for factors of the HLA system, October 2007 update*

International Journal of Immunogenetics — Mon, 21 Jan 2008 05:36:50 +0100

International Journal of Immunogenetics, Volume 0, Issue 0, Page ???, OnlineEarly Articles. (Source: International Journal of Immunogenetics)

Nomenclature for factors of the HLA system, November 2007 update*

International Journal of Immunogenetics — Mon, 21 Jan 2008 05:30:31 +0100

International Journal of Immunogenetics, Volume 0, Issue 0, Page ???, OnlineEarly Articles. (Source: International Journal of Immunogenetics)

Genetic characterization of the chemokine receptor CXCR4 gene in lagomorphs: comparison between the families Ochotonidae and Leporidae

International Journal of Immunogenetics — Mon, 21 Jan 2008 05:30:30 +0100

International Journal of Immunogenetics, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Summary Chemokines receptors are transmembrane proteins that bind chemokines. Chemokines and their receptors are known to play a crucial role in the immune system and in pathogen entry. There is evidence that myxoma virus, the causative agent of ... (Source: International Journal of Immunogenetics)

Porcine IL12A and IL12B gene mapping, variation and evidence of association with lytic complement and blood leucocyte proliferation traits

International Journal of Immunogenetics — Fri, 04 Jan 2008 06:26:51 +0100

This study was aimed to investigate the role of IL12A and IL12B as candidate ... (Source: International Journal of Immunogenetics)

Distribution of KIR genes in the Czech population

International Journal of Immunogenetics — Fri, 04 Jan 2008 06:26:46 +0100

International Journal of Immunogenetics, Volume 35, Issue 1, Page 57-61, February 2008. Summary Killer cells immunoglobulin-like receptors (KIRs) are a family of inhibitory and activating receptors expressed mainly by natural killer (NK) cells and few subsets of T lymphocytes. KIRs regulate NK cells’ activity through interactions with ... (Source: International Journal of Immunogenetics)

Lack of association between HLA-A, -B and -DRB1 alleles and the development of SARS: a cohort of 95 SARS-recovered individuals in a population of Guangdong, southern China

International Journal of Immunogenetics — Fri, 04 Jan 2008 06:26:18 +0100

International Journal of Immunogenetics, Volume 35, Issue 1, Page 69-74, February 2008. Summary Severe acute respiratory syndrome (SARS), caused by infection with a novel coronavirus (SARS-CoV), was the first major novel infectious disease at the beginning of the 21st century, with China especially affected. SARS was characterized by high ... (Source: International Journal of Immunogenetics)

Promoter polymorphism of the IL-18 gene is associated with atopic asthma in Tunisian children

International Journal of Immunogenetics — Tue, 18 Dec 2007 19:05:39 +0100

International Journal of Immunogenetics, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Summary Several lines of evidence point to a relevant role of IL-18 in the process of asthma. Some studies suggest that the polymorphism in the gene of IL-18 can be involved in many inflammatory and atopic diseases such as asthma. The aim of our study is ... (Source: International Journal of Immunogenetics)

A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with psoriasis

International Journal of Immunogenetics — Tue, 18 Dec 2007 08:35:11 +0100

International Journal of Immunogenetics, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Summary Psoriasis is one of the most common inflammatory diseases of skin. MCP-1 is an important CC-type chemokine responsible for monocytes and T lymphocytes recruitment in inflammatory conditions. A single nucleotide polymorphism of the MCP-1 gene in ... (Source: International Journal of Immunogenetics)

Distribution of the CTLA-4 single nucleotide polymorphisms CT60G>A and +49A>G in psoriasis vulgaris patients and control individuals from a Polish Caucasian population

International Journal of Immunogenetics — Tue, 18 Dec 2007 08:35:05 +0100

International Journal of Immunogenetics, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Summary Psoriasis vulgaris is a multifactorial disease with an autoimmune component, and T lymphocytes seem to be involved in its aetiology. CTLA-4 molecule is an important down-regulator of T-lymphocyte activation, and several polymorphisms of the CTLA-... (Source: International Journal of Immunogenetics)

Killer cell immunoglobulin-like receptors on NK cells: the how, where and why

International Journal of Immunogenetics — Tue, 18 Dec 2007 08:35:01 +0100

International Journal of Immunogenetics, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Summary Natural killer (NK) cells have killer cell immunoglobulin-like receptors (KIR) that recognize and interact with HLA class I antigen. The KIRs are a multigene family and its members are often highly polymorphic. Evidence is emerging from disease-... (Source: International Journal of Immunogenetics)

Discovery of HLA-B*480102 in Taiwanese

International Journal of Immunogenetics — Tue, 27 Nov 2007 19:20:36 +0100

International Journal of Immunogenetics, Volume 0, Issue 0, Page ???, -Not available-. Summary Human leucocyte antigen (HLA)-B48, an antigen within 7C CREG (cross-reacting group) (Steiner et al., 2001) that cross-reacts frequently with HLA-B40 (i.e. HLA-B60 and -B61) group of antibodies serologically, can be found in Alaskan Natives (... (Source: International Journal of Immunogenetics)

HLA-DPβ chain may confer the susceptibility to hepatitis C virus-associated hypertrophic cardiomyopathy

International Journal of Immunogenetics — Tue, 27 Nov 2007 11:39:44 +0100

International Journal of Immunogenetics, Volume 0, Issue 0, Page ???, -Not available-. Summary Hypertrophic cardiomyopathy (HCM) is a heart muscle disease characterized by hypertrophy and diastolic dysfunction of cardiac ventricles. It is suggested that one possible aetiology of HCM is the hepatitis C virus (HCV) infection, but molecular ... (Source: International Journal of Immunogenetics)

Genetic susceptibility to SLE is associated with TNF-alpha gene polymorphism –863, but not –308 and –238, in Thai population

International Journal of Immunogenetics — Wed, 14 Nov 2007 05:44:13 +0100

International Journal of Immunogenetics, Volume 34, Issue 6, Page 425-430, December 2007. Summary The production of cytokine varies among individuals and correlates with the polymorphism of cytokine genes. Three functional single nucleotide polymorphisms (SNPs) at position –863, –308, and –238 in the tumour necrosis factor alpha (TNF-α) gene ... (Source: International Journal of Immunogenetics)

The interleukin-6 (IL6)–174 G/C promoter genotype is associated with the presence of septic shock and the ex vivo secretion of IL6

International Journal of Immunogenetics — Wed, 14 Nov 2007 05:44:13 +0100

International Journal of Immunogenetics, Volume 34, Issue 6, Page 413-418, December 2007. Summary Septic shock is associated with a high mortality and an excessive activation of immune cascades. Interleukin (IL)-6 has been found to be a key cytokine in the pathogenesis of severe sepsis, but the importance of a regulatory polymorphism within ... (Source: International Journal of Immunogenetics)

Single nucleotide polymorphisms and haplotype of MD-1 gene associated with high serum IgE phenotype with mite-sensitive allergy in Taiwanese children

International Journal of Immunogenetics — Wed, 14 Nov 2007 05:44:13 +0100

International Journal of Immunogenetics, Volume 34, Issue 6, Page 407-412, December 2007. Summary MD-1 (myeloid differentiation 1; also known as Ly86, lymphocyte antigen 86), interacting with RP105, plays an important role in Toll-like receptor 4 (TLR4) signalling pathway. It has been suggested to be involved in the pathological mechanism of ... (Source: International Journal of Immunogenetics)

A note of thanks to referees of Volume 34, 2007

International Journal of Immunogenetics — Wed, 14 Nov 2007 05:43:25 +0100

International Journal of Immunogenetics, Volume 34, Issue 6, Page i, December 2007. (Source: International Journal of Immunogenetics)

Nomenclature for factors of the HLA system, update September 2007*

International Journal of Immunogenetics — Wed, 07 Nov 2007 19:10:45 +0100

International Journal of Immunogenetics, Volume 0, Issue 0, Page ???, -Not available-. (Source: International Journal of Immunogenetics)

Analysis of vascular endothelial growth factor gene 936 C/T polymorphism in patients with familial Mediterranean fever

International Journal of Immunogenetics — Wed, 07 Nov 2007 06:18:33 +0100

International Journal of Immunogenetics, Volume 0, Issue 0, Page ???, -Not available-. Summary Vascular endothelial growth factor (VEGF) is a cytokine that promotes endothelial cell proliferation, leucocyte chemotaxis and expression of adhesion molecules and is a major mediator of vascular permeability. It has been demonstrated that VEGF ... (Source: International Journal of Immunogenetics)

Association between recipient ICAM-1 K469 allele and renal allograft acute rejection

International Journal of Immunogenetics — Thu, 04 Oct 2007 21:52:50 +0100

International Journal of Immunogenetics Volume 0, Issue 0, Page ???-???. Summary Intercellular adhesion molecule 1 (ICAM-1) genetic polymorphisms (G241R and K469E) have been implicated in several autoimmune and inflammatory conditions. Investigating a sample of living-unrelated donor (LURD) kidney transplant pairs, we revealed... (Source: International Journal of Immunogenetics)

Nomenclature for factors of the HLA system, update July 2007*

International Journal of Immunogenetics — Thu, 04 Oct 2007 07:39:22 +0100

International Journal of Immunogenetics Volume 0, Issue 0, Page ???-???. (Source: International Journal of Immunogenetics)

Association of MCP-1 and CCR2 polymorphisms with the risk of late acute rejection after renal transplantation in Korean patients

International Journal of Immunogenetics — Thu, 04 Oct 2007 07:39:22 +0100

International Journal of Immunogenetics Volume 0, Issue 0, Page ???-???. Summary Among the factors modulating transplant rejection, chemokines and their respective receptors deserve special attention. Increased expression of monocyte chemoattractant protein-1 (MCP-1) and its corresponding receptor (chemokine receptor-2, CCR2) ... (Source: International Journal of Immunogenetics)

HLA class II similarities in Iranian Kurds and Azeris

International Journal of Immunogenetics — Thu, 04 Oct 2007 07:39:22 +0100

International Journal of Immunogenetics Volume 0, Issue 0, Page ???-???. Summary The genetic relationship between Kurds and Azeris of Iran was investigated based on human leukocyte antigen (HLA) class II profiles. HLA typing was performed using polymerase chain reaction/restriction fragment-length polymorphism (PCR/RFLP) and P... (Source: International Journal of Immunogenetics)

Nomenclature for factors of the HLA system, update August 2007*

International Journal of Immunogenetics — Thu, 04 Oct 2007 07:39:21 +0100

International Journal of Immunogenetics Volume 0, Issue 0, Page ???-???. (Source: International Journal of Immunogenetics)

CCL5/RANTES chemokine gene promoter polymorphisms are not associated with atopic and nonatopic asthma in a Spanish population

International Journal of Immunogenetics — Thu, 04 Oct 2007 07:39:21 +0100

International Journal of Immunogenetics Volume 0, Issue 0, Page ???-???. Summary CCL5/RANTES, a member of the C–C chemokine family, is a potent eosinophil, monocyte, basophile and lymphocyte chemo-attractant at the site of inflammation. Recent studies revealed that a functional mutation at the –403 position in the promoter may... (Source: International Journal of Immunogenetics)

Two new highly polymorphic markers in the 3' UTR region of the PLA2G7 gene

International Journal of Immunogenetics — Tue, 11 Sep 2007 18:06:53 +0100

We described two new highly polymorphic markers located 31 bp downstream of the last nucleotide of exon 12 in the 3' UTR region of the gene PLA2G7: 1344 +31TGn AGm. Eight and 14 alleles were observed for the AG and TG repeats, respectively. These ... (Source: International Journal of Immunogenetics)

International Journal of Immunogenetics via MedWorm.com

Isolation, polymorphism and expression study of two distinct major histocompatibility complex class II B genes from half-smooth tongue sole (Cynoglossus semilaevis)

Human leucocyte antigen class II DRB1 and DQB1 associations in human immunodeficiency virus-infected patients of Mumbai, India

Changes in frequency of IDDM-associated HLA DQB, CTLA4 and INS alleles

HLA-B*15 subtypes distribution in Han population in Beijing, China, as compared with those of other populations

Analysis of DEFB1 regulatory SNPs in cystic fibrosis patients from North-Eastern Italy

Compound KIR-HLA genotype analyses in the Iranian population by a novel PCR–SSP assay

Association of mannose-binding lectin polymorphisms and HBV outcome in a South Indian population

BCL10 as a new candidate gene for immune response in pigs: cloning, expression and association analysis

The mutations of Th1 cell-specific T-box transcription factor may be associated with a predominant Th2 phenotype in gastric cancers

Highly sensitivity adhesion molecules detection in hereditary haemochromatosis patients reveals altered expression

AKT1 polymorphisms are associated with tuberculosis in the Chinese population

Dimorphism of TAP-1 gene in Caucasian with juvenile myoclonic epilepsy and in Tunisian with idiopathic generalized epilepsies

FcεRIα gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients

Nomenclature for factors of the HLA system, update October 2009

Nomenclature for factors of the HLA system, update November 2009

Nomenclature for factors of the HLA system, update December 2009

TNF-α promoter polymorphisms in multiple sclerosis: no association with −308 and −238 alleles, but the −857 alleles in associated with the disease in Turkish patients

Analysis of cytokine genes polymorphism as markers for inhibitor development in haemophilia A

Killer cell immunoglobulin-like receptor gene diversity in a Caucasian population of Southern Brazil

Immunity-related gene single nucleotide polymorphisms associated with Rhodococcus equi infection in foals

Study on VNTR polymorphism of gene IL-1RA in 19 Chinese populations

Toll-like receptors 2 and 4 gene polymorphisms in a southeastern Chinese population with tuberculosis

Association of IL-1 gene complex members with ankylosing spondylitis in Chinese Han population

Functional polymorphism of cytotoxic T-lymphocyte antigen 4 and nasopharyngeal carcinoma susceptibility in a Chinese population

Nomenclature for factors of the HLA system, update September 2009*

Nomenclature for factors of the HLA system, update July 2009*

Nomenclature for factors of the HLA system, update August 2009*

Molecular analysis of HumDN1 VNTR polymorphism of the human deoxyribonuclease I in systemic lupus erythematosus

HLA-G 3'-UTR SNP and 14-bp deletion polymorphisms in Portuguese and Guinea-Bissau populations

Associations of the IL-1 and TNF gene polymorphisms in the susceptibility to duodenal ulcer disease in Chinese Han population

Oct-1 is responsible for the C-33T polymorphism effect in the IL-4 promoter

A novel Y331X nonsense mutation in TNFRSF1A gene in two unrelated Turkish families with periodic fever syndrome

Genetic variation in CXCL12 and risk of cervical carcinoma: a population-based case–control study

A unique display of toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms in non-Han Chinese Hani population

Detection of a rare Caucasoid HLA-DRB1*0337 in a Taiwanese bone marrow donor using sequence-based typing method

Plasma carnitine ester profiles in Crohn's disease and ulcerative colitis patients with different IGR2230a_1 genotypes

Analysis of the complete genomic sequence of HLA-A alleles in the Chinese Han population

A novel HLA-B allele, B*5214, detected in a Taiwanese volunteer bone marrow donor using a sequence-based typing method

Gene polymorphism in transforming growth factor-beta codon 10 is associated with susceptibility to Giardiasis

HLA allele and haplotype frequencies in the Albanian population and their relationship with the other European populations

Structural polymorphism of the mannose-binding lectin 2 (MBL2 ) gene in HCV-infected patients with a serological marker for thyroid autoimmunity

Confirmation of allele HLA-A*3116 found in a family of a leukaemia patient with Caucasian and Caribbean origin

Analysis of high-resolution HLA-A, -B, -Cw, -DRB1, and -DQB1 alleles and haplotypes in 718 Chinese marrow donors based on donor–recipient confirmatory typings

Nomenclature for factors of the HLA system, June 2009 update*

MHC microsatellites in a Southern Brazilian population

Nomenclature for factors of the HLA system, April 2009 update*

Nomenclature for factors of the HLA system, May 2009 update*

Dominant, non-MHC genetic control of food allergy in an adjuvant-free mouse model

Association between a common IL10 distal promoter haplotype and IgE production in individuals with atopic dermatitis

The influence of class II transactivator and interleukin-6 polymorphisms on the production of antibodies to donor human leucocyte antigen mismatches in renal allograft recipients

Sequence-based characterization of swine leucocyte antigen alleles in commercially available porcine cell lines

Nomenclature for factors of the HLA system, January 2009 update*

Nomenclature for factors of the HLA system, February 2009 update*

Nomenclature for factors of the HLA system, March 2009 update*

MHC class 2 deficiency and X-linked agammaglobulinaemia in a consanguineous extended family

Genetic susceptibility to haemorrhagic fever with renal syndrome caused by Hantaan virus in Chinese Han population

Detection of a novel HLA-B27 allele, B*2740, in Taiwanese volunteer bone marrow donors by sequence-based typing: curiosity rewarded

The role of the CCR5 Δ32 polymorphism in abdominal aortic aneurysms

Nomenclature for factors of the HLA system, December 2008 update*

Haplotype analysis of HLA-A, -B antigens and -DRB1 alleles in south Indian HIV-1-infected patients with and without pulmonary tuberculosis

The combination of polymorphisms within MCP-1 and IL-1β associated with ulcerative colitis

Decreased T-cell receptor excision DNA circles in peripheral blood mononuclear cells among benzene-exposed workers

Nomenclature for factors of the HLA system, November 2008 update*

Identification of a novel HLA-A allele, A*1131, in a Taiwanese

Molecular cloning and expression analysis of the pig small ubiquitin-like modifier (SUMO) gene family

A comparative analysis of the products of GROEL-1 gene from Chlamydia trachomatis serovar D and the HSP60 var1 transcript from Homo sapiens suggests a possible autoimmune response

Nomenclature for factors of the HLA system, September 2008 update*

The non-inherited maternal HLA haplotype affects the risk for type 1 diabetes

Identification of new variants within the two functional genes CCL3 and CCL3L encoding the CCL3 (MIP-1α) chemokine: implications for HIV-1 infection

The peopling of Madeira archipelago (Portugal) according to HLA genes

NRAMP1 (SLC11A1) gene polymorphisms that correlate with autoimmune versus infectious disease susceptibility in tuberculosis and rheumatoid arthritis

MCP-1 and CCR2 gene polymorphisms in Czech patients with allergic disorders

Analysis of ERCC2/XPD functional polymorphisms in systemic lupus erythematosus

CRP and FCGR2A genes have an epistatic effect on carotid artery intima-media thickness: the Cardiovascular Risk in Young Finns Study

Nomenclature for factors of the HLA system, August 2008 update*

Nomenclature for factors of the HLA system, July 2008 update*

Unusual amplification pattern by SSP HLA-B typing led to discovery of a novel HLA-C allele

The G/G genotype of transforming growth factor beta 1 (TGF-β1) single nucleotide (+915G/C) polymorphism coincident with other host and environmental factors is associated with irreversible bronchoconstriction in asthmatics

HLA haplotypes in recurrent aphthous stomatitis: a mode­ of inheritance?

HLA haplotypes in recurrent aphthous stomatitis: a mode of inheritance?

Characterization of two novel HLA class I alleles: HLA-A310103 and HLA-B9531