MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'International Journal of Nanomedicine' source. Tue, 07 Feb 2012 10:30:09 +0100 http://www.medworm.com/index.php?rid=5535760&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Frestoration-of-renal-hemodynamics-and-functions-during-black-cumin-nig-peer-reviewed-article-JEP Yusuksawad M, Chaiyabutr N (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=5535760 Sat, 24 Dec 2011 04:10:59 +0100 5535760 http://www.medworm.com/index.php?rid=5158718&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Fthe-essential-oils-component-p-cymene-induces-proton-leak-through-fo-a-peer-reviewed-article-JEP Custódio JBA, Ribeiro MV, Silva FSG, Machado M, Sousa MC (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=5158718 Fri, 26 Aug 2011 13:31:21 +0100 5158718 http://www.medworm.com/index.php?rid=5050336&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Fa2a-adenosine-receptor-mediated-increase-in-coronary-flow-in-hyperlipi-peer-reviewed-article-JEP Teng B, Mustafa SJ (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=5050336 Fri, 22 Jul 2011 14:23:31 +0100 5050336 http://www.medworm.com/index.php?rid=4820700&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Feffects-of-single-dose-morning-and-evening-administration-of-pravastat-peer-reviewed-article-JEP Kamal S (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=4820700 Sat, 14 May 2011 06:12:36 +0100 4820700 http://www.medworm.com/index.php?rid=4676579&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Fcomparison-of-the-effects-of-the-oral-anticancer-platinumiv-complexes--peer-reviewed-article-JEP Olszewski U, Ulsperger E, Geissler K, Hamilton G (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=4676579 Tue, 05 Apr 2011 11:39:18 +0100 4676579 http://www.medworm.com/index.php?rid=4631392&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Fpreparation-of-ultrasound-microbubbles-crosslinked-to-albumin-nanopart-peer-reviewed-article-JEP Jun J, Shang-Yi J, Xia H, Wen-Ping L (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=4631392 Fri, 25 Mar 2011 05:31:55 +0100 4631392 http://www.medworm.com/index.php?rid=4600436&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Fnovel-compounds-in-the-treatment-of-lung-cancer-current-and-developing-peer-reviewed-article-JEP Rudi Bao, Pokman Chan (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=4600436 Thu, 17 Mar 2011 04:36:34 +0100 4600436 http://www.medworm.com/index.php?rid=4532113&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Finvestigational-new-drugs-in-the-treatment-of-inflammatory-bowel-disea-peer-reviewed-article-JEP Imogen Williams, Jason Goh (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=4532113 Tue, 01 Mar 2011 15:54:20 +0100 4532113 http://www.medworm.com/index.php?rid=4501495&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Frole-of-calcium-in-morphine-dependence-and-naloxone-precipitated-withd-peer-reviewed-article-JEP Vikas Seth, Prerna Upadhyaya, Vijay Moghe, et al (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=4501495 Mon, 21 Feb 2011 18:43:13 +0100 4501495 http://www.medworm.com/index.php?rid=4330885&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Fcomplexation-of-amphotericin-b-and-curcumin-with-serum-albumins-solubi-peer-reviewed-article-JEP Avinash K Kudva, MN Manoj, Bale M Swamy, et al (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=4330885 Tue, 11 Jan 2011 15:37:12 +0100 4330885 http://www.medworm.com/index.php?rid=4219609&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Feffects-of-insulin-resistance-and-testosterone-on-the-participation-of-peer-reviewed-article-JEP Harish Vasudevan, Sally Lau, Jihong Jiang, et al (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=4219609 Thu, 02 Dec 2010 09:45:56 +0100 4219609 http://www.medworm.com/index.php?rid=4175557&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Fangiotensin-1-7mas-receptor-axis-activation-ameliorates-the-changes-in-peer-reviewed-article-JEP Kulwinder Singh, Tajinder Singh, PL Sharma (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=4175557 Thu, 18 Nov 2010 01:06:14 +0100 4175557 http://www.medworm.com/index.php?rid=4133450&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Frecent-advances-in-the-treatment-of-multiple-sclerosis-peer-reviewed-article-JEP Jeffrey L Bennett, Augusto A Miravalle (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=4133450 Thu, 04 Nov 2010 21:42:08 +0100 4133450 http://www.medworm.com/index.php?rid=4055642&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Feffect-of-combined-therapy-of-diabinese-and-nicotinic-acid-on-liver-en-peer-reviewed-article-JEP Comfort C Monago, Frank Onwuka, Erhabor Osaro (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=4055642 Mon, 11 Oct 2010 20:42:09 +0100 4055642 http://www.medworm.com/index.php?rid=3902788&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Fcurrent-and-emerging-therapies-for-the-treatment-of-osteoporosis-peer-reviewed-article-JEP Jill Waalen (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3902788 Thu, 26 Aug 2010 10:20:50 +0100 3902788 http://www.medworm.com/index.php?rid=3902787&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Fcytoprotective-effect-of-semecarpus-anacardium-against-toxicity-induce-peer-reviewed-article-JEP Jaya Aseervatham, Shanthi Palanivelu, Panchanadham Sachdanandam (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3902787 Thu, 26 Aug 2010 10:20:50 +0100 3902787 http://www.medworm.com/index.php?rid=3794674&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Feffect-of-breastfeeding-piperine-on-the-learning-of-offspring-mice-int-peer-reviewed-article-JEP Ali Akbar Moghadamnia, Vahid Zangoori, Seyed Sadegh Zargar-Nattaj, et al (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3794674 Wed, 28 Jul 2010 08:14:58 +0100 3794674 http://www.medworm.com/index.php?rid=3794673&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Fthe-influence-of-dexamethasone-and-the-role-of-some-antioxidant-vitami-peer-reviewed-article-JEP H A Nounou, M M Deif, M Arafah (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3794673 Wed, 28 Jul 2010 08:14:58 +0100 3794673 http://www.medworm.com/index.php?rid=3794672&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Fclinical-evaluation-of-a-novel-herbal-dental-cream-in-plaque-formation-peer-reviewed-article-JEP Sunita Amrutesh, J Malini, Prakash S Tandur, et al (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3794672 Wed, 28 Jul 2010 08:14:58 +0100 3794672 http://www.medworm.com/index.php?rid=3729776&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Fthe-warfarinndashcranberry-juice-interaction-revisited-a-systematic-in-peer-reviewed-article-JEP Ngoc Ngo, Scott J Brantley, Daniel R Carrizosa, et al (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3729776 Wed, 07 Jul 2010 08:00:38 +0100 3729776 http://www.medworm.com/index.php?rid=3714072&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Fpharmacogenomics-of-chronic-hepatitis-c-therapy-with-genome-wide-assoc-peer-reviewed-article-JEP Chun-Hsiang Wang, Yuchi Hwang, Eugene Lin (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3714072 Thu, 01 Jul 2010 08:01:03 +0100 3714072 http://www.medworm.com/index.php?rid=3644666&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Fpharmacological-modulation-of-brain-levels-of-glutamate-and-gaba-in-ra-peer-reviewed-article-JEP Sahar Mohamed Kamal (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3644666 Wed, 09 Jun 2010 15:41:18 +0100 3644666 http://www.medworm.com/index.php?rid=3629509&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Fnephroprotection-of-lacidipine-against-gentamycin-induced-nephrotoxici-peer-reviewed-article-JEP Sahar Kamal (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3629509 Fri, 04 Jun 2010 15:28:29 +0100 3629509 http://www.medworm.com/index.php?rid=3326876&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Feffect-of-amlodipine-a-calcium-channel-antagonist-on-gonadal-steroid-o-peer-reviewed-article-JEP FC Onwuka, KC Patrick-I wuanyanwu, CK Nnodu, et al (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3326876 Wed, 03 Mar 2010 17:17:54 +0100 3326876 http://www.medworm.com/index.php?rid=3298225&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Feffects-of-an-oral-dose-of-l-glutamic-acid-on-circulating-neurotransmi-peer-reviewed-article-JEP Fuad Lechin, Bertha van der Dijs, Betty Pardey-Maldonado, et al (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3298225 Tue, 23 Feb 2010 17:18:54 +0100 3298225 http://www.medworm.com/index.php?rid=3275708&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Fcardioprotective-and-beta-adrenoceptor-antagonistic-activity-of-a-newl-peer-reviewed-article-JEP Lokesh K Bhatt, Jyotika Bansal, Poonam Piplani, SL Bodhankar, A Veeranjaneyulu (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3275708 Tue, 16 Feb 2010 16:51:52 +0100 3275708 http://www.medworm.com/index.php?rid=3266834&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Fpotential-antidiabetic-and-antioxidant-activities-of-morus-indica-and--peer-reviewed-article-JEP R Pradeep Kumar, D Sujatha, TS Mohamed Saleem, C Madhusudhana Chetty, D Ranganayakulu (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3266834 Fri, 12 Feb 2010 16:43:15 +0100 3266834 http://www.medworm.com/index.php?rid=3266833&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Fcystone-an-ayurvedic-polyherbal-formulation-inhibits-adherence-of-urop-peer-reviewed-article-JEP Satyakumar Vidyashankar, Puttanarasaiah Maheshkumar, Pralhad S Patki (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3266833 Fri, 12 Feb 2010 16:43:15 +0100 3266833 http://www.medworm.com/index.php?rid=3262519&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Fpotential-antidiabetic-and-antioxidant-activities-of-morus-indica-and--peer-reviewed-article-JEP R Pradeep Kumar, D Sujatha, TS Mohamed Saleem, C Madhusudhana Chetty, D Ranganayakulu (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3262519 Thu, 11 Feb 2010 16:52:45 +0100 3262519 http://www.medworm.com/index.php?rid=3262518&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Fcystone-an-ayurvedic-polyherbal-formulation-inhibits-adherence-of-urop-peer-reviewed-article-JEP Satyakumar Vidyashankar, Puttanarasaiah Maheshkumar, Pralhad S Patki (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3262518 Thu, 11 Feb 2010 16:52:45 +0100 3262518 http://www.medworm.com/index.php?rid=3111276&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Feffect-of-antiretroviral-drugs-on-the-pharmacodynamics-of-gliclazide-w-peer-reviewed-article-JEP S K Mastan, K Eswar Kumar (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3111276 Tue, 22 Dec 2009 16:27:33 +0100 3111276 http://www.medworm.com/index.php?rid=3111275&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Fpilot-safety-evaluation-of-varenicline-for-the-treatment-of-methamphet-peer-reviewed-article-JEP Todd Zorick, Rajkumar J Sevak, Karen Miotto, et al (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3111275 Tue, 22 Dec 2009 16:27:33 +0100 3111275 http://www.medworm.com/index.php?rid=2963009&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Ffunctional-role-of-the-nicotinic-arm-of-the-acetylcholine-regulatory-a-peer-reviewed-article-JEP Juan Arredondo, Denys Omelchenko, Alexander I Chernyavsky, et al (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2963009 Thu, 05 Nov 2009 16:37:40 +0100 2963009 http://www.medworm.com/index.php?rid=1461748&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D265 Milica Radisic1,2, Rohin K Iyer1, Shashi K Murthy31Institute of Biomaterials and Biomedical Engineering, 2Department of Chemical Engineering and Applied Chemistry, University of Toronto, Ontario, Canada; 3Department of Chemical Engineering, Northeastern University, Boston, MA, USA Abstract: This review describes recent work in cell separation using micro- and nanoscale technologies. These devices offer several advantages over conventional, macroscale separation systems in terms of sample volumes, low cost, portability, and potential for integration with other analytical techniques. More importantly, and in the context of modern medicine, these technologies provide tools for point-of-care diagnostics, drug discovery, and chemical or biological agent detection. This review describes work in ... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461748 Thu, 22 May 2008 16:54:23 +0100 1461748 http://www.medworm.com/index.php?rid=1461747&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D266 Rajesh Vasita, Dhirendra S Katti Department of Biological Sciences and Bioengineering, Indian Institute of Technology – Kanpur, Kanpur, Uttar Pradesh, IndiaAbstract: Developing scaffolds that mimic the architecture of tissue at the nanoscale is one of the major challenges in the field of tissue engineering. The development of nanofibers has greatly enhanced the scope for fabricating scaffolds that can potentially meet this challenge. Currently, there are three techniques available for the synthesis of nanofibers: electrospinning, self-assembly, and phase separation. Of these techniques, electrospinning is the most widely studied technique and has also demonstrated the most promising results in terms of tissue engineering applications. The availability of a wide range of natural and s... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461747 Thu, 22 May 2008 16:54:23 +0100 1461747 http://www.medworm.com/index.php?rid=1461746&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D267 Zheng-Rong Lu, Aaron M Mohs, Yuda Zong, Yi Feng Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, USA Abstract: Macromolecular gadolinium (Gd)(III) complexes have a prolonged blood circulation time and can preferentially accumulate in solid tumors, depending on the tumor blood vessel hyperpermeability, resulting in superior contrast enhancement in magnetic resonance (MR) cardiovascular imaging and cancer imaging as shown in animal models. Unfortunately, safety concerns related to these agents’ slow elimination from the body impede their clinical development. Polydisulfide Gd(III) complexes have been designed and developed as biodegradable macromolecular magnetic resonance imaging (MRI) contrast agents to facilitate the clearance of... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461746 Thu, 22 May 2008 16:54:23 +0100 1461746 http://www.medworm.com/index.php?rid=1461745&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D268 Saba Choudhary1, Mikal Berhe1, Karen M Haberstroh1, Thomas J Webster1,2 1Weldon School of Biomedical Engineering and 2School of Materials Engineering, Purdue University, West Lafayette, IN, USAAbstract: In the body, vascular cells continuously interact with tissues that possess nanostructured surface features due to the presence of proteins (such as collagen and elastin) embedded in the vascular wall. Despite this fact, vascular stents intended to restore blood flow do not have nanoscale surface features but rather are smooth at the nanoscale. As the first step towards creating the next generation of vascular stent materials, the objective of this in vitro study was to investigate vascular cell (specifically, endothelial, and vascular smooth muscle cell) adhesion on nanostructured compared... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461745 Thu, 22 May 2008 16:54:23 +0100 1461745 http://www.medworm.com/index.php?rid=1461744&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D270 Dinesh Shenoy1, Wei Fu2, Jane Li3, Curtis Crasto3, Graham Jones3, Charles DiMarzio4, Srinivas Sridhar2, Mansoor Amiji1 Departments of 1Pharmaceutical, Sciences, 2Physics, 3Chemistry and Chemical Biology, 4Electrical and Computer Engineering, and the Nanomedicine Consortium, Northeastern University, Boston, MA, USA Abstract: For the development of surface-functionalized gold nanoparticles as cellular probes and delivery agents, we have synthesized hetero-bifunctional poly(ethylene glycol) (PEG, MW 1500) having a thiol group on one terminus and a reactive functional group on the other for use as a flexible spacer. Coumarin, a model fluorescent dye, was conjugated to one end of the PEG spacer and gold nanoparticles were modified with coumarin-PEG-thiol. Surface attachment of coumarin thr... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461744 Thu, 22 May 2008 16:54:23 +0100 1461744 http://www.medworm.com/index.php?rid=1461743&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D271 Jin-Oh You1, Yu-San Liu2, Yu-Chuan Liu1, Kye-Il Joo1, Ching-An Peng1,2 1Department of Chemical Engineering and 2Department of Materials Science, University of Southern California, Los Angeles, CA, USAAbstract: Developing methods to label viruses with fluorescent moieties has its merits in elucidating viral infection mechanisms and exploring novel antiviral therapeutics. Fluorescent quantum dots (QDs), an emerging probe for biological imaging and medical diagnostics, were employed in this study to tag retrovirus encoding enhanced green fluorescent protein (EGFP) genes. Electrostatic repulsion forces generated from both negatively charged retrovirus and QDs were neutralized by cationic Polybrene®, forming colloidal complexes of QDs–virus. By examining the level of EGFP expression i... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461743 Thu, 22 May 2008 16:54:23 +0100 1461743 http://www.medworm.com/index.php?rid=1461742&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D272 Dongwoo Khang1, Michiko Sato4, Rachel L Price2, Alexander E Ribbe3Thomas J Webster2,4 1Department of Physics, 2Weldon School of Biomedical Engineering, 3Purdue Laboratory of Chemical Nanotechnology and Departments of Chemistry, and 4School of Materials Engineering, PurdueAbstract: In an effort to develop better orthopedic implants, osteoblast (bone-forming cells) adhesion was determined on microscale patterns (30 μm lines) of carbon nanofibers placed on polymer substrates. Patterns of carbon nanofibers (CNFs) on a model polymer (polycarbonate urethane [PCU]) were developed using an imprinting method that placed CNFs in selected regions. Results showed the selective adhesion and alignment of osteoblasts on CNF patterns placed on PCU. Results also showed greater attraction forces between ... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461742 Thu, 22 May 2008 16:54:23 +0100 1461742 http://www.medworm.com/index.php?rid=1461741&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D273 Venkataramani Anandan1, Yeswanth L Rao1, Guigen Zhang1,2,3 1Micro/Nano Bioengineering Lab, Department of Biological and Agricultural Engineering, 2Nanoscale Science and Engineering Center, 3Faculty of Engineering, University of Georgia, GA, USAAbstract: Fabrication of metallic nanopillar array structures and their application as electrodes in electrochemical-based biosensors are discussed in this report. Vertically standing nanopillar array structures were fabricated using an electrodeposition technique and their electrochemical characteristics were evaluated. For possible use in biosensing applications, these standing nanopillars should have sufficient mechanical stability to sustain the capillary forces caused by the nanopillar – liquid interactions in aqueous environment and shoul... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461741 Thu, 22 May 2008 16:54:23 +0100 1461741 http://www.medworm.com/index.php?rid=1461740&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D274 In this study, the adhesive targeting and drug specificity of modified liposomal vesicles on human-scar-producing cells, keloid fibroblasts, were investigated. Keloids express abundant levels of mucopolysaccharides and receptor tyrosine kinase (RTK). In this report, the structural properties, drug release kinetics, and therapeutic availability of silkfibroin- coated, emodin-loaded liposomes (SF-ELP), compared with uncoated, emodin-loaded liposomes (ELP), were investigated. SF-ELP had a highly organized lamellae structure, which contributed to 55% of the liposomal diameter. This modified liposomal structure decreased emodin release rates by changing the release kinetics from a swelling and diffusional process to a purely diffusional process, probably due to steric hindrance. SF-ELP also inc... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461740 Thu, 22 May 2008 16:54:23 +0100 1461740 http://www.medworm.com/index.php?rid=1461739&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D275 Andrei L Turinsky, Christoph W Sensen Sun Center of Excellence for Visual Genomics, University of Calgary, Faculty of Medicine, Department of Biochemistry and Molecular Biology, Calgary, AB, CanadaAbstract: Genetic diseases and developmental patterns should be studied on several levels: from macroscale (organs and tissues) to nanoscale (cells, genes, proteins). Due to the overwhelming complexity of the life science data, it is common that disparate data pieces are meticulously stored but never fully analyzed or correlated. We have begun to develop a novel methodology based on virtual reality techniques for the study of these phenomena. Our key approach to knowledge integration is a top-down mapping of data onto visual contexts. For each organism that we want to study, a structural model is... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461739 Thu, 22 May 2008 16:54:23 +0100 1461739 http://www.medworm.com/index.php?rid=1461738&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D276 This report presents a new and simple methodology for the synthesis of multicomponent peptide vaccines, named the peptide crosslinked micelles (PCMs). The PCMs are core shell micelles designed to deliver peptide antigens and immunostimulatory DNA to antigen-presenting cells (APCs). They are composed of immunostimulatory DNA, peptide antigen, and a thiopyridal derived poly(ethylene glycol)-polylysine block copolymer. The peptide antigen acts as a crosslinker in the PCM strategy, which allows the peptide antigen to be efficiently encapsulated into the PCMs and also stabilizes them against degradation by serum components. Cell culture studies demonstrated that the PCMs greatly enhance the uptake of peptide antigens into human dendritic cells.Keywords: composite, crosslinking, peptide, vaccine... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461738 Thu, 22 May 2008 16:54:23 +0100 1461738 http://www.medworm.com/index.php?rid=1461737&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D277 Viroj Wiwanitkit Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandAbstract: Hemoglobin variants in which a frameshift results in chain elongation are unusual. Hemoglobin Pakse (Hb Pakse) is an unstable hemoglobin with abnormal elongation, first described in Indochina. An alpha2-globin gene termination codon mutation, TAA → TAT or Term → Tyr, has been described in the pathogenesis of Hb Pakse. This abnormality causes a frameshift that elongates the alpha chain amino acids. Computer-based protein structure modeling was used in a bioinformatics analysis of the tertiary structure of these elongated amino acid sequences. The elongated part of Hb Pakse showed additional helices, which may cause the main alteration in Hb Pakse. Abnormali... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461737 Thu, 22 May 2008 16:54:23 +0100 1461737 http://www.medworm.com/index.php?rid=1461736&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D278 Viroj Wiwanitkit Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandAbstract: Hemoglobinopathies are important inherited disorders with high prevalence in many tropical countries. Prediction of protein nanostructure and function is a great challenge in proteomics and structural genomics. Identifying the point vulnerable to mutation is a new trend in research on disorders at the genomic and proteomic level. A bioinformatics analysis was performed to determine the positions that tend to correspond with peptide motifs in the amino acid sequence of alpha and beta globin chains. To identify the weak linkage in alpha globin and beta globin chains, a new bioinformatics tool, GlobPlot, was used. For the alpha globin chain, 22 positions were identifie... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461736 Thu, 22 May 2008 16:54:23 +0100 1461736 http://www.medworm.com/index.php?rid=1461735&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D279 Viroj Wiwanitkit Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandAbstract: To prevent side effects of excessive accumulation of iron in the body, chelation therapy is recommended in transfusion-dependent patients. The reaction between deferiprone and iron to form a complex red substance can be described as 3 molecules of the chelator, deferiprone, reacting with a molecule of iron. However, the actual mechanism of the deferiprone – iron binding reaction is not well understood. A quantum chemical analysis of the deferiprone – iron binding reaction was performed, focusing on the reaction between 1 molecule of deferiprone and 1 molecule of iron. The two main alternative pathways for the deferiprone – iron binding reaction wer... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461735 Thu, 22 May 2008 16:54:23 +0100 1461735 http://www.medworm.com/index.php?rid=1461734&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D281 Katherine Bowman, Kam W Leong Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USAAbstract: Chitosan is a widely available, mucoadhesive polymer that is able to increase cellular permeability and improve the bioavailability of orally administered protein drugs. It can also be readily formed into nanoparticles able to entrap drugs or condense plasmid DNA. Studies on the formulation and oral delivery of such chitosan nanoparticles have demonstrated their efficacy in enhancing drug uptake and promoting gene expression. This review summarizes some of these findings and highlights the potential of chitosan as a component of oral delivery systems. Keywords: chitosan, oral delivery, nanoparticles (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461734 Thu, 22 May 2008 16:54:23 +0100 1461734 http://www.medworm.com/index.php?rid=1461733&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D282 Konstantinos Tziomalos, Vasilios G Athyros Atherosclerosis and Metabolic Syndrome Units, 2nd Prop. Department of internal Medicine, Aristotelian University, Hippokration Hospital, Thessaloniki, GreeceAbstract: Cardiovascular disease is the major cause of mortality worldwide and accounts for approximately 40% of all deaths. Dyslipidemia is one of the primary causes of atherosclerosis and effective interventions to correct dyslipidemia should form an integral component of any strategy aimed at preventing cardiovascular disease. Fibrates have played a major role in the treatment of hyperlipidemia for more than two decades. Fenofibrate is one of the most commonly used fibrates worldwide. Since fenofibrate was first introduced in clinical practice, a major drawback has been its low bioavailabil... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461733 Thu, 22 May 2008 16:54:23 +0100 1461733 http://www.medworm.com/index.php?rid=1461732&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D283 Amanda R Lowery1, André M Gobin1, Emily S Day1, Naomi J Halas2, Jennifer L West11Department of Bioengineering, 2Department of Electrical and Computer Engineering, Rice University, Houston, TX, USA Abstract: Consisting of a silica core surrounded by a thin gold shell, nanoshells possess an optical tunability that spans the visible to the near infrared (NIR) region, a region where light penetrates tissues deeply. Conjugated with tumor-specific antibodies, NIR-absorbing immunonanoshells can preferentially bind to tumor cells. NIR light then heats the bound nanoshells, thus destroying the targeted cells. Antibodies can be consistently bound to the nanoshells via a bifunctional polyethylene glycol (PEG) linker at a density of ~150 antibodies per nanoshell. In vitro studies have conf... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461732 Thu, 22 May 2008 16:54:23 +0100 1461732 http://www.medworm.com/index.php?rid=1461731&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D285 V Manojlovic1, J Djonlagic1, B Obradovic1, V Nedovic2, B Bugarski1 1Faculty of Technology and Metallurgy, 2Faculty of Agriculture, University of Belgrade, Belgrade, Serbia and Montenegro  Abstract: The process of electrostatic extrusion as a method for cell immobilization was investigated that could be used for potential applications in medicine. An attempt was made to assess the effects of cell addition and polymer concentration on the overall entrapment procedure, ie, on each stage of immobilization: polymer–cell suspension rheological characteristics, electrostatic extrusion process, and the process of gelation. The findings should contribute to a better understanding of polymer–cell interactions, which could be crucial in possible medical treatments. Alginate... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461731 Thu, 22 May 2008 16:54:23 +0100 1461731 http://www.medworm.com/index.php?rid=1461730&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D287 Narayan Bhattarai1, Hassna R Ramay1, Shinn-Huey Chou2, Miqin Zhang11Department of Material science and engineering, 2Department of Bioengineering, University of Washington, Seattle, WA, USAAbstract:  Nanoparticles of ~10 nm in diameter made with chitosan or lactic acid-grafted chitosan were developed for high drug loading and prolonged drug release. A drug encapsulation efficiency of 92% and a release rate of 28% from chitosan nanoparticles over a 4-week period were demonstrated with bovine serum protein. To further increase drug encapsulation, prolong drug release, and increase chitosan solubility in solution of neutral pH, chitosan was modified with lactic acid by grafting D,L-lactic acid onto amino groups in chitosan without using a catalyst. The lactic acid-grafted chitosan nanopa... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461730 Thu, 22 May 2008 16:54:23 +0100 1461730 http://www.medworm.com/index.php?rid=1461729&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D288 Ian O Smith1, Laura R McCabe2, Melissa J Baumann1 1Department of Chemical Engineering and Materials Science, 2Department of Physiology, Michigan State University, East Lansing, MI, USA  Abstract:  Porous bone tissue engineering scaffolds were fabricated using both nano hydroxyapatite (nano HA) powder (20 nm average particle size) and micro HA powder (10 µm average particle size), resulting in sintered scaffolds of 59 vol% porosity and 8.6±1.9 µm average grain size and 72 vol% porosity and 588±55 nm average grain size, respectively. Scanning electron microscopy was used to measure both the grain size and pore size. MC3T3-E1 osteoblast (OB) attachment and proliferation on both nano HA and micro HA porous scaffolds were quantified. As expected, OB... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461729 Thu, 22 May 2008 16:54:23 +0100 1461729 http://www.medworm.com/index.php?rid=1461728&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D289 Gwendolyn A Lawrie, Jodie Robinson, Simon Corrie, Kym Ford, Bronwyn J Battersby, Matt Trau Centre for Nanotechnology and Biomaterials, The University of Queensland, St Lucia, Australia  Abstract:  Microarrays have received significant attention in recent years as scientists have firstly identified factors that can produce reduced confidence in gene expression data obtained on these platforms, and secondly sought to establish laboratory practices and a set of standards by which data are reported with integrity.  microsphere-based assays represent a new generation of diagnostics in this field capable of providing substantial quantitative and qualitative information from gene expression profiling. However, for gene expression profiling, this type of platform is still ... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461728 Thu, 22 May 2008 16:54:23 +0100 1461728 http://www.medworm.com/index.php?rid=1461727&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D290 Elena M de Juan-Pardo, Mike Bao-Trong Hoang, Irina M ConboyDepartment of Bioengineering, University of California at Berkeley, Berkley, CA, USAAbstract:  This work combines expertise in stem cell biology and bioengineering to define the system for geometric control of proliferation and differentiation of myogenic progenitor cells. We have created an artificial niche of myogenic progenitor cells, namely, modified extracellular matrix (ECM) substrates with spatially embedded growth or differentiation factors (GF, DF) that predictably direct muscle cell fate in a geometric pattern. Embedded GF and DF signal progenitor cells from specifically defined areas on the ECM successfully competed against culture media for myogenic cell fate determination at a clearly defined boundary. Differentia... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461727 Thu, 22 May 2008 16:54:23 +0100 1461727 http://www.medworm.com/index.php?rid=1461726&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D291 Nicki K Baman1, Galen B Schneider2, Treniece L Terry3, Rebecca Zaharias2, Aliasger K Salem1,3,4 1Department of Biomedical Engineering, College of Engineering, 2Department of Prosthodontics and Dows Institute for Dental Research, College of Dentistry, 3Department of Chemical and Biochemical Engineering, College of Engineering, 4Division of Pharmaceutics, College of Pharmacy, University of Iowa, Iowa City, IA, USA  Abstract:  We demonstrate spatial control over cell attachment on biodegradable surfaces by flowing cell adhesive poly (D-lysine) (PDL) in a trifluoroethanol (TFE)–water mixture through microfluidic channels placed on a biodegradable poly (lactic acid)–poly (ethylene glycol) (PLA–PEG) substrate. The partial solvent mixture swells the PLA&ndash... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461726 Thu, 22 May 2008 16:54:23 +0100 1461726 http://www.medworm.com/index.php?rid=1461725&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D292 Joseph M Kinsella1, Albena Ivanisevic1,2 1Weldon School of Biomedical Engineering, 2Department of Chemistry, Purdue University, West Lafayette, IN, USA  Abstract:  Dip-pen nanolithography is used to selectively modify the SiOx area between microfabricated electrodes. The modified surface is characterized by atomic force microscopy, X-ray photoelectron spectroscopy, force volume imaging, and adhesion maps. The functionalized complex architecture is used for the localization of DNA coated with magnetic nanoparticles. The strategy reported here can become the basis for the construction of a number of functional devices. The devices can utilize the unique recognition properties of the DNA and the magnetic properties of the nanoparticles that template them.Keywords: DNA nano... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461725 Thu, 22 May 2008 16:54:23 +0100 1461725 http://www.medworm.com/index.php?rid=1461724&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D855 E H Chowdhury, Toshihiro AkaikeDepartment of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Midori-ku, Yokohama, Japan Abstract: Increasing attention is being paid on synthetic DNA delivery systems considering some potential life-threatening effects of viral particles, for development of gene-based nanomedicine in the 21st century. In the current nonviral approaches, most of the efforts have been engaged with organic macromolecules like lipids, polymers, and peptides, but comparatively fewer attempts were made to evaluate the potential of inorganic materials for gene delivery. We recently reported that biodegradable nanoparticles of carbonate apatite are highly efficient in transfecting a wide variety of mammalian cells. Here we sh... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461724 Thu, 22 May 2008 16:54:23 +0100 1461724 http://www.medworm.com/index.php?rid=1461723&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D856 David AmrolDepartment of Internal Medicine, University of South Carolina School of Medicine, Columbia, SC, USAAbstract: Azithromycin extended release (Zmax®, Pfizer Inc) is a novel single-dose administration formulation of azithromycin which won FDA approval in June 2005 and is currently approved for the treatment of community acquired pneumonia and acute bacterial sinusitis. Azitromycin is incorporated into sustained-release microspheres which release the drug slowly through 200 µm pores. Because of this sustained release mechanism, most of the drug is released into the lower gastrointestinal tract, reducing gastrointestinal side-effects, and allowing for a higher dose to be administered. The unique pharmacological properties and extremely long half-life of azithromycin make thi... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461723 Thu, 22 May 2008 16:54:23 +0100 1461723 http://www.medworm.com/index.php?rid=1461722&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D857 This article summarizes the pathophysiology of AMD stressing potential applications from nanotechnology.Keywords: macular, nanotechnology, AMD, retinal degeneration, gene therapy (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461722 Thu, 22 May 2008 16:54:23 +0100 1461722 http://www.medworm.com/index.php?rid=1461721&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D858 Thomas J WebsterDivision of Engineering, Brown University; Division of Orthopedic Surgery, Brown University Medical School, Providence, RI, USAAbstract: Welcome to the second year of the International Journal of Nanomedicine! As our readers know, nanomedicine research worldwide is going strong. As an example, the US National Science Foundation forecasts that the global market for nanotechnology-related products and services will reach US$1 trillion by 2015 (NSF 2007). Nanomedicine may be defined as the monitoring, repair, construction, and control of human biological systems using engineered nanodevices and nanostructures at the molecular level. Although this definition still seems quite broad and all-encompassing, it is clear that this definition is founded on the design, synthesis, and e... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461721 Thu, 22 May 2008 16:54:23 +0100 1461721 http://www.medworm.com/index.php?rid=1461720&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D859 Thea Thomas1, Graham Foster21Specialist Registrar in Gastroenterology, University College London Hospital NHS Trust, London; 2Queen Marys School of Medicine, Barts and The London NHS Trust, LondonAbstract: Nanotechnology is the application of nanotechnology within medicine. An illustration of this is the use of pegylation as a means of modifying naturally occurring proteins which may have clinical applications, in order to improve the pharmacodynamics of the protein resulting in an effective medication. An example of this is pegylated interferon. The purpose of this review is to examine the chemistry, clinical pharmacology, pharmacokinetics, pharmacodynamics, and clinical studies with 40 kDa pegylated interferon to illustrate the general principles of pegylated biological proteins. The use... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461720 Thu, 22 May 2008 16:54:23 +0100 1461720 http://www.medworm.com/index.php?rid=1461719&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D860 Sayana R Thomas, Deepak KhuntiaDepartment of Human Oncology, University of Wisconsin, Madison, WI, USAAbstract: Despite recent advances in technology, targeting, and chemotherapy, brain metastasis from non-small cell lung cancer (NSCLC) remains a significant problem. The vast majority of patients with this diagnosis undergo whole brain radiation therapy (WBRT). However, outcomes are still quite poor with median survivals measured in only months. In an effort to enhance outcomes from external beam radiation treatments, radiosensitizers have been investigated. Motexafin gadolinium (MGd) (Xcytrin®, Sunnyvale, CA, USA) is a novel radiation sensitizer with a unique mechanism of action that may increase the therapeutic index of WBRT for patients with brain metastases, particularly in those w... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461719 Thu, 22 May 2008 16:54:23 +0100 1461719 http://www.medworm.com/index.php?rid=1461718&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D861 Theresa Barnes, Robert MootsAcademic Rheumatology, University of Liverpool, UKAbstract: Anti-TNFα therapy has revolutionized the treatment of rheumatoid arthritis (RA) and other inflammatory diseases. These drugs are powerful and expensive. A new anti-TNFα agent, a nanomolecule comprising a humanized Fab' antibody fragment against TNFα with a polyethylene glycol tail, is shortly to complete phase III trials in RA. In this review we will discuss the construct of this new molecule, data from trials so far, and its potential place in the market place.Keywords: certolizumab pegol, TNFα, rheumatoid arthritis, nanomolecule (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461718 Thu, 22 May 2008 16:54:23 +0100 1461718 http://www.medworm.com/index.php?rid=1461717&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D862 Kyriaki Mystakidou1, Eleni Tsilika1, Marinos Tsiatas2, Lambros Vlahos31Pain Relief and Palliative Care Unit, Department of Radiology, Areteion Hospital, School of Medicine, University of Athens, Greece; 2Department of Clinical Therapeutics, Alexandra Hospital, University of Athens, Athens, Greece; 3Department of Radiology, Areteion Hospital, School of Medicine, University of Athens, Athens, GreeceAbstract: Pain is experienced by most cancer patients and represents an important issue in the clinical setting. Breakthrough pain is a transitory flare of pain that occurs in most cancer patients on a background of otherwise controlled persistent pain. Treatment of breakthrough pain is a challenging phenomenon. Oral transmucosal fentanyl citrate (OTFC; Actiq®, Cephalon, UK), a new opioid form... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461717 Thu, 22 May 2008 16:54:23 +0100 1461717 http://www.medworm.com/index.php?rid=1461716&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D863 Matthew V Brumm, Quan Dong NguyenWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USAAbstract: Uveitis is a potentially sight-threatening inflammatory eye disease caused by multiple infectious and non-infectious etiologies for which the standard of care involves corticosteroids or various immunomodulary therapy (IMT) drugs. These available treatments, although effective, may cause significant morbidity and sometimes mortality in uveitis patients due to their toxic side-effects and the necessity of long-term therapy to prevent recurrences. In order to avoid the systemic toxicity of corticosteroids and IMT or the repeated injections of local steroids necessary to control ocular inflammation, and to prevent development of cumulative damage resulting from... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461716 Thu, 22 May 2008 16:54:23 +0100 1461716 http://www.medworm.com/index.php?rid=1461715&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D864 Ian Olver1, Suhas Shelukar2, Karen C Thompson21The Cancer Council Australia, Sydney, NSW, Australia 2001; 2Merck Research Laboratories, West Point, Pennsylvania, USAAbstract: Aprepitant, a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors, is the active ingredient of EMEND® which has recently been approved by the FDA for the prevention of chemotherapy-induced nausea and vomiting (CINV). Aprepitant undergoes extensive metabolism, primarily via CYP3A4 mediated oxidation. It is eliminated primarily by metabolism and is not renally excreted. The apparent terminal half-life in humans ranged from 9 to 13 hours. Early development studies led to the development of a nanoparticle formulation to enhance exposure and minimize food effects. Two large randomized t... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461715 Thu, 22 May 2008 16:54:23 +0100 1461715 http://www.medworm.com/index.php?rid=1461714&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D865 Usha Panchapakesan, Siska Sumual, Carol PollockDepartment of Medicine, The University of Sydney, Renal Research Group, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, NSW, AustraliaAbstract: Anemia is a common complication of chronic kidney disease (CKD), with erythropoietin deficiency being the major contributing factor. The availability of erythropoiesisstimulating agents (ESAs) has been a seminal advance in the treatment of anemia related to chronic kidney disease. Over the course of the last decade and a half, newer generations of ESAs have become available. The first-generation ESAs or epoetins have a relatively shorter half-life and have traditionally been administered up to 3 times per week intravenously or subcutaneously to maintain adequate... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461714 Thu, 22 May 2008 16:54:23 +0100 1461714 http://www.medworm.com/index.php?rid=1461713&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D866 Lotte Dinesen, Simon TravisGastroenterology Unit, John Radcliffe Hospital, Oxford, UKAbstract: A variety of targets for therapeutic intervention are based upon advances in understanding of the immunopathogenesis of Crohn’s disease. Crohn’s disease is initiated by an innate immune response, which eventuates in a T-cell driven process, characterized by a T-helper cell 1 type cytokine profile. Several new treatments now focus on suppressing T-cell differentiation or T-cell inflammation. Since inflammatory bowel disease (IBD) represents a state of dysregulated inflammation, drugs that augment the anti-inflammatory response have the potential to downregulate inflammation and thereby hopefully modify the disease. Tumour necrosis factor (TNF) is a major target of research and clinical... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461713 Thu, 22 May 2008 16:54:23 +0100 1461713 http://www.medworm.com/index.php?rid=1461712&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D867 In this study, we show that functionalized NPs conjugated to monoclonal antibodies can be used to rapidly and specifically detect respiratory syncytial virus in vitro and in vivo. These results suggest that functionalized NPs can provide direct, rapid, and sensitive detection of viruses and thereby bridge the gap between current cumbersome virus detection assays and the burgeoning need for more rapid and sensitive detection of viral agents.Keywords: RSV, virus, nanoparticle, bioconjugated, functionalized (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461712 Thu, 22 May 2008 16:54:23 +0100 1461712 http://www.medworm.com/index.php?rid=1461711&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D869 In this study, nanoscale dendritic RGD clusters were synthesized based on Starburst™ anionic G3.5 and cationic G4.0 polyamidoamine (PAMAM) dendrimers. The multiple terminal functional groups on the outermost layer of the dendrimer were coupled with RGD tripeptides. Biofunctionalized dendrimer structures were found to be highly dependent on the generation and the extent of peptide modification (ie, number of peptides per PAMAM dendrimer). Fluorescein isothiocyanate (FITC)-conjugated PAMAM dendrimers were utilized to monitor cellular internalization of dendrimers by adherent fibroblasts. Anionic G3.5-based dendritic RGD clusters have been shown to have no negative effect on fibroblast viability and a concentration-dependent effect on lowering cell adhesion on tissue culture polystyrene... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461711 Thu, 22 May 2008 16:54:23 +0100 1461711 http://www.medworm.com/index.php?rid=1461710&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D871 Furqan Haq1, Venkatramani Anandan1, Charles Keith2,4, Guigen Zhang1,3,41Micro/Nano Bioengineering Lab, Department of Biological and Agricultural Engineering; 2Department of Cellular Biology, 3Nanoscale Science and Engineering Center, 4Faculty of Engineering, University of Georgia, Athens, GA 30602, USAAbstract: We investigated the effect of nanoscale topography on neurite development in pheochromocytoma (PC12 cells) by culturing the cells on substrates having nanoscale pillars and pores with sizes comparable with filipodia. We found that cells on nanopillars and nanopores developed fewer and shorter neurites than cells on smooth substrates, and that cells on nanopores developed more and longer neurites than cells on nanopillars. These results suggest that PC12 cells were spatially awa... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461710 Thu, 22 May 2008 16:54:23 +0100 1461710 http://www.medworm.com/index.php?rid=1461709&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1075 Massimo Bottini1,2,4, Federica D’Annibale2, Andrea Magrini2, Fabio Cerignoli1, Yutaka Arimura1, Marcia I Dawson1, Enrico Bergamaschi5, Nicola Rosato3, Antonio Bergamaschi1, Tomas Mustelin11Burnham Institute for Medical Research, La Jolla, CA, USA; 2NAST and Department of Environmental, Occupational and Social Medicine, University of Rome Tor Vergata, Rome, Italy; 3NAST and Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy; 4INFN, Laboratori Nazionali di Frascati, Frascati, Italy; 5Department of Clinical Medicine, Nephrology and Health Sciences, University of Parma, Parma, ItalyAbstract: To enhance diagnostic or therapeutic efficacy, novel nanomaterials must be engineered to function in biologically relevant environments, be visi... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461709 Thu, 22 May 2008 16:54:23 +0100 1461709 http://www.medworm.com/index.php?rid=1461708&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1076 Luis Brito, Mansoor AmijiDepartment of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA, USAAbstract: The current treatment for coronary restenosis following balloon angioplasty involves the use of a mechanical or a drug-eluting stent. Despite the high usage of commercially-available drug-eluting stents in the cardiac field, there are a number of limitations. This review will present the background of restenosis, go briefly into the molecular and cellular mechanisms of restenosis, the use of mechanical stents in coronary restenosis, and will provide an overview of the drugs and genes tested to treat restenosis. The primary focus of this article is to present a comprehensive overview on the use of nanoparticulate delivery systems in the treatment of rest... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461708 Thu, 22 May 2008 16:54:23 +0100 1461708 http://www.medworm.com/index.php?rid=1461707&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1077 Qian Chen1, Yuan Fan1,2, Lalita Udpa2, Virginia M Ayres11Electronic and Biological Nanostructures Laboratory, 2Nondestructive Evaluation Laboratory, College of Engineering, Michigan State University, East Lansing, MI, USAAbstract: Image processing techniques are bringing new insights to biomedical research. The automatic recognition and classification of biomedical objects can enhance work efficiency while identifying new inter-relationships among biological features. In this work, a simple rule-based decision tree classifier is developed to classify typical features of mixed cell types investigated by atomic force microscopy (AFM). A combination of continuous wavelet transform (CWT) and moment-based features are extracted from the AFM data to represent that shape information of different ... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461707 Thu, 22 May 2008 16:54:23 +0100 1461707 http://www.medworm.com/index.php?rid=1461706&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1078 Donald T HaynieArtificial Cell Technologies, Inc., New Haven, CT, USA; Department of Chemistry, Central Michigan University, Mount Pleasant, MI, USA; Department of Surgery, University of Connecticut School of Medicine, Farmington, CT, USAAbstract: For many, nanotechnology seems far removed from biology. There is none the less a sense in which nanotechnology was born of medicine. (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461706 Thu, 22 May 2008 16:54:23 +0100 1461706 http://www.medworm.com/index.php?rid=1461705&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1079 In this study, the effect of nanoparticle size and collagenase treatment on penetration of carboxylated polystyrene nanoparticles was systematically assessed in a multicellular spheroid model. Penetration of the nanoparticles into the spheroid core was limited to particles smaller than 100 nm. Collagenase treatment of spheroids resulted in significantly increased penetration of nanoparticles up to 100 nm with only a minor increase in particle penetration observed for particles larger than 100 nm. Collagenase was immobilized onto the surface of nanoparticles for site-specific degradation of ECM proteins. Collagenase-coated, 100 nm nanoparticles demonstrated a 4-fold increase in the number of particles delivered to the spheroid core compared with control nanoparticles. Thus, nanoparticle del... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461705 Thu, 22 May 2008 16:54:23 +0100 1461705 http://www.medworm.com/index.php?rid=1461704&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1080 Tianyi Ke1, Eun-Kee Jeong2, Xuli Wang1, Yi Feng3, Dennis L Parker2, Zheng-Rong Lu11Departments of Pharmaceutics and Pharmaceutical Chemistry; 2Radiology and Materials Science and 3Engineering, University of Utah, Salt Lake City, UT, USAAbstract: Cyclic Arg-Gly-Asp-D-Phe-Lys [c(RGDfK)] targeted poly(L-glutamic acid) (PGA)-(Gd-DO3A) conjugate with a biodegradable cystamine spacer was prepared and evaluated for in vivo detection of an angiogenesis biomarker, ανβ3 integrin, in neoplastic tissues with T1 mapping, a quantitative magnetic resonance imaging (MRI) technique. The binding activity of the c(RGDfK) containing conjugate was investigated using in vitro vitronectin assay with human prostate carcinoma DU145 cell line and Kaposi’s sarcoma SLK cell line. The peptide c(RGD... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461704 Thu, 22 May 2008 16:54:23 +0100 1461704 http://www.medworm.com/index.php?rid=1461703&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1081 Challa SSR Kumar1, Carola Leuschner3, Michelle Urbina1,2, Tevhida Ozkaya1,4, Josef Hormes11Center for Advanced Microstructures and Devices, Louisiana State University, Baton Rouge, LA, USA; 2Biological and Agricultural Engineering, Louisiana State University, Baton Rouge, LA, USA; 3Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA; 4Chemistry Department, Fatih University, Istanbul, TurkeyAbstract: Superparamagnetic iron oxide nanoparticles (SPIONs) bound directly to luteinizing hormone releasing hormone (LHRH) have shown high efficiency for intracellular uptake to breast cancer cells, MDA-MB-435S.luc. We demonstrate in this communication that inclusion of a small spacer molecule such as glutaric acid (Glu) in between SPION and LHRH increases fur... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461703 Thu, 22 May 2008 16:54:23 +0100 1461703 http://www.medworm.com/index.php?rid=1461702&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1082 Henk-Jan van Manen1, Aart A van Apeldoorn2, Ruud Verrijk3, Clemens A van Blitterswijk2, Cees Otto11Biophysical Engineering Group, Institute for Biomedical Technology (BMTI), and MESA+ Institute for Nanotechnology, University of Twente, The Netherlands; 2Polymer Chemistry and Biomaterials Group, Institute for Biomedical Technology (BMTI), University of Twente, The Netherlands; 3OctoPlus, Zernikedreef 12, The Netherlands Abstract: Micro- and nanospheres composed of biodegradable polymers show promise as versatile devices for the controlled delivery of biopharmaceuticals. Whereas important properties such as drug release profiles, biocompatibility, and (bio)degradability have been determined for many types of biodegradable particles, information about particle degradation inside phagocytic ce... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461702 Thu, 22 May 2008 16:54:23 +0100 1461702 http://www.medworm.com/index.php?rid=1461701&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1083 Seth D McCullen1,2, Derrick R Stevens3, Wesley A Roberts3, Laura I Clarke3, Susan H Bernacki1, Russell E Gorga2, Elizabeth G Loboa11Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, USA; 2Fiber and Polymer Science Program, Department of Textile Engineering, Chemistry and Science, North Carolina State University, Raleigh, NC, USA; 3Department of Physics, North Carolina State University, Raleigh, NC, USA Abstract: Electrospun nanocomposite scaffolds were fabricated by encapsulating multi-walled carbon nanotubes (MWNT) in poly (lactic acid) (PLA) nanofibers. Scanning electron microscopy (SEM) confirmed the fabrication of nanofibers, and transmission electron microscopy identified the alignment and dis... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461701 Thu, 22 May 2008 16:54:23 +0100 1461701 http://www.medworm.com/index.php?rid=1461700&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1084 This study furthers understanding of the geometric properties of surface nanotopographies that affect cellular response. It is hoped that identification of the mechanisms governing cell-topography interactions will allow rule-based design of biomaterial surface to engineer specific cellular responses.Keywords: nanotopography, replication, biomaterials, cell adhesion, roughness (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461700 Thu, 22 May 2008 16:54:23 +0100 1461700 http://www.medworm.com/index.php?rid=1461699&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1085 Biswajit Mukherjee1, Balaram Patra1, Buddhadev Layek1, Arup Mukherjee21Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India; 2Department of Chemical Technology, Calcutta University, Kolkata, IndiaAbstract: The present study was designed to develop and compare acyclovir containing nano-vesicular liposomes and niosomes based on cholesterol, soya L-α-lecithin and nonionic surfactant, span 20. The effort was made to study in vitro whether acyclovir-loaded nanovesicles could sustain the release of the drug by increasing residence time and thus, acyclovir could reduce its dose-related systemic toxicity. There were good vesicular distributions in both of the niosomes and the liposomes. The obtained vesicles were within 1 µm and about 35% of them were within a s... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461699 Thu, 22 May 2008 16:54:23 +0100 1461699 http://www.medworm.com/index.php?rid=1461698&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1086 Shashi K MurthyDepartment of Chemical Engineering, Northeastern UniversityAbstract: Nanoparticles are materials with overall dimensions in the nanoscale, ie, under 100 nm. In recent years, these materials have emerged as important players in modern medicine, with clinical applications ranging from contrast agents in imaging to carriers for drug and gene delivery into tumors. Indeed, there are some instances where nanoparticles enable analyses and therapies that simply cannot be performed otherwise. However, nanoparticles also bring with them unique environmental and societal challenges, particularly in regard to toxicity. This review aims to highlight the major contributions of nanoparticles to modern medicine and also discuss environmental and societal aspects of their use.Keywords: nanop... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461698 Thu, 22 May 2008 16:54:23 +0100 1461698 http://www.medworm.com/index.php?rid=1461697&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1087 Jiantang Sun1,3, Ming-Qiang Zhu1, Kun Fu2,3, Nastassja Lewinski1, Rebekah A Drezek1,21Departments of Bioengineering; 2Electrical and Computer Engineering; 3Rice Quantum Institute, Rice University, Houston, TX, USAAbstract: In this paper, we report the use of lead sulfide quantum dot (PbS QD) bioconjugates as near infrared (NIR) contrast agents for targeted molecular imaging with expanded emission wavelengths beyond 1000 nm. The red-shifted emission band, coupled with the small particle size, which will facilitate clearance, both afford PbS QDs unique properties for noninvasive, high resolution in vivo NIR imaging applications. We have performed imaging experiments at the molecular level using surface-modified PbS NIR QDs, together with our lab-built NIR imaging system. This novel instrumen... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461697 Thu, 22 May 2008 16:54:23 +0100 1461697 http://www.medworm.com/index.php?rid=1461696&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1088 Zhi Ping Xu1, Tara L Walker2, Kerh-lin Liu1, Helen M Cooper2, GQ Max Lu1, Perry F Bartlett21ARC Centre for Functional Nanomaterials, Australian Institute of Bioengineering and Nanotechnology; 2Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, AustraliaAbstract: We prepared stable homogeneous suspensions with layered double hydroxide (LDH) nanoparticles for in vitro gene delivery tests. The viability of HEK 293T cells in the presence of LDH nanoparticles at different concentrations was investigated. This revealed 50% cell viability at 500 µg/mL of LDH nanoparticles that is much higher than 50–100 µg/mL used for the delivery tests. The supercoiled pEF-eGFP plasmid (ca. 6100 base pairs) was mixed with LDH nanoparticle suspensions for anion exchang... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461696 Thu, 22 May 2008 16:54:23 +0100 1461696 http://www.medworm.com/index.php?rid=1461695&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1477 Thomas J WebsterDivisions of Engineering and Orthopedics, Brown University, Providence, RI, USAAbstract: On July 25, 2007, the Nanotechnology Task Force of the Food and Drug Administration (FDA) of the United States released a report which addressed the regulatory challenges presented by products that use nanotechnology (FDA 2007). Since most of these potential products involve nanomaterial interactions with biological tissues, this report directly speaks to the field of nanomedicine. A general finding of the report was that nanoscale materials present regulatory challenges similar to those posed by products using other emerging technologies, with one big difference. Regulatory challenges may be magnified because at this nanometer scale, properties of a material relevant to their safety an... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461695 Thu, 22 May 2008 16:54:23 +0100 1461695 http://www.medworm.com/index.php?rid=1461694&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1478 Alvaro Mata1,2, Cynthia Boehm2,3, Aaron J Fleischman2,4, George F Muschler2,3,5, Shuvo Roy2,41Department of Chemical and Biomedical Engineering, Cleveland State University; 2Department of Biomedical Engineering, The Cleveland Clinic Foundation; 3Bone Biology Laboratory, The Cleveland Clinic Foundation; 4BioMEMS Laboratory, The Cleveland Clinic Foundation; 5Department of Orthopaedic Surgery, The Cleveland Clinic FoundationAbstract: Growth characteristics of human connective tissue progenitor (CTP) cells were investigated on smooth and textured substrates, which were produced using MEMS (microelectromechanical systems) fabrication technology. Human bone marrow derived cells were cultured for 9 days under conditions promoting osteoblastic differentiation on polydimethylsiloxane (PDMS) substra... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461694 Thu, 22 May 2008 16:54:23 +0100 1461694 http://www.medworm.com/index.php?rid=1461693&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1479 Christin E Petre, Dirk P DittmerLineberger Comprehensive Cancer Center, Center for AIDS Research (CfAR) and Department of Microbiology and Immunology, University of North Carolina, Chapel Hill NC, USAAbstract: Anthracycline compounds including daunorubicin are the foundation of many modern chemotherapeutic regimens. However, the side-effects of these compounds can be severe, leading to alopecia, nausea, immune deficiency, and cardiotoxicity. For immunocompromised patients with aggressive Kaposi’s sarcoma (KS), these complications often preclude the completion of appropriate chemotherapeutic regimens. This review focuses on the development and efficacy of liposomal daunorubicin (DaunoXome®; DNX) carriers for the treatment of KS. Encouragingly, DNX demonstrated increased in vivo st... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461693 Thu, 22 May 2008 16:54:23 +0100 1461693 http://www.medworm.com/index.php?rid=1461692&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1480 Melike Üner, Gülgün YenerIstanbul University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Beyazit 34119 Istanbul, TurkeyAbstract: Solid lipid nanoparticles (SLN) have been reported to be an alternative system to emulsions, liposomes, microparticles and their polymeric counterparts for various application routes since the early 1990s due to their advantages. Various research groups have also increasingly focused on improving their stability in body fluids after administration by coating of particles with hydrophilic molecules such as poly(ethylene)glycol (PEG) derivatives. Altering surface characteristics by coating SLN with hydrophilic molecules improves plasma stability and biodistribution, and subsequent bioavailability of drugs entrapped. Their storage s... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461692 Thu, 22 May 2008 16:54:23 +0100 1461692 http://www.medworm.com/index.php?rid=1461691&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1481 Gillian Barratt1, Stéphane Bretagne21UMR CNRS 8612, Laboratoire de Physico-chimie, Pharmacotechnie et Biopharmacie, Univ. Paris-Sud 11, Faculté de Pharmacie, IFR 141, Châtenay-Malabry, France 2UMR BIPAR 956, Laboratoire de Parasitologie-Mycologie, Faculté de Médecine, Univ. Paris XII, Créteil, FranceAbstract: The polyene antibiotic Amphotericin B (AMB) is one of the first therapeutic agents to be marketed commercially as nanosized formulations in which the drug is associated with lipids as liposomes or complexes. In this way, its renal toxicity is reduced and its therapeutic index improved. This review summarizes the particular properties of AMB which justify this type of formulation and the early work leading up to their development. The clinical r... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461691 Thu, 22 May 2008 16:54:23 +0100 1461691 http://www.medworm.com/index.php?rid=1461690&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1482 Nahor Haddish-Berhane1, Jenna L Rickus1,2,3, Kamyar Haghighi11Department of Agricultural and Biological Engineering, Purdue University, 2Weldon School of Biomedical Engineering, 3Physiological Sensing Facility at the Bindley Bioscience Center, West Lafayette, IN 47907, USAAbstract: Multiscale computational modeling of drug delivery systems (DDS) is poised to provide predictive capabilities for the rational design of targeted drug delivery systems, including multi-functional nanoparticles. Realistic, mechanistic models can provide a framework for understanding the fundamental physico-chemical interactions between drug, delivery system, and patient. Multiscale computational modeling, however, is in its infancy even for conventional drug delivery. The wide range of emerging nanotechnology sys... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461690 Thu, 22 May 2008 16:54:23 +0100 1461690 http://www.medworm.com/index.php?rid=1461689&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1483 Matthew G Chown, Sanjay KumarDepartment of Bioengineering, University of California, Berkeley, CA, USAAbstract: The structure, physiology, and fate of living cells are all highly sensitive to mechanical forces in the cellular microenvironment, including stresses and strains that originate from encounters with the extracellular matrix (ECM), blood and other flowing materials, and neighbouring cells. This relationship between context and physiology bears tremendous implications for the design of cellular micro-or nanotechnologies, since any attempt to control cell behavior in a device must provide the appropriate physical microenvironment for the desired cell behavior. Cells sense, process, and respond to biophysical cues in their environment through a set of integrated, multi-scale structur... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461689 Thu, 22 May 2008 16:54:23 +0100 1461689 http://www.medworm.com/index.php?rid=1461688&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1484 Ashish Udhrain1, Keith M Skubitz2, Donald W Northfelt31Department of Medicine, Mayo Clinic Arizona, AZ, USA; 2Division of Hematology, Oncology, and Transplantation, University of Minnesota, MN, USA; 3Division of Hematology – Medical Oncology, Mayo Clinic Arizona, AZ, USAAbstract: Kaposi’s sarcoma is a vascular tumor of skin and viscera first described in 1872. Prior to the 1980s, this disease was rarely seen in the Western world, but was quite prevalent in Sub-Saharan African countries. Since the onset of the HIV pandemic in the 1980s, the incidence of Kaposi’s sarcoma has increased markedly in Africa and continues to be a significant problem in association with AIDS in Western countries. Many therapies have been demonstrated to be effective in the treatment of HIV-r... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461688 Thu, 22 May 2008 16:54:23 +0100 1461688 http://www.medworm.com/index.php?rid=1461687&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1485 Rohan Bhavane1, Efstathios Karathanasis2, Ananth V Annapragada11School of Health Information Sciences, University of Texas-Houston Health Science Center, Houston, Texas, USA; 2Department of Chemical Engineering, University of Houston, Houston, Texas, USAAbstract: Nanostructured agglomerated vesicles encapsulating ciprofloxacin were evaluated for modulated delivery from the lungs in a healthy rabbit model. An aliphatic disulfide crosslinker, cleavable by cysteine was used to form cross-links between nanosized liposomes to form the agglomerates. The blood levels of drug after pulmonary instillation of free ciprofloxacin, liposomal ciprofloxacin, and the agglomerated liposomes encapsulating ciprofloxacin were evaluated. The liposomes and agglomerated vesicles showed extended release of drug i... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461687 Thu, 22 May 2008 16:54:23 +0100 1461687 http://www.medworm.com/index.php?rid=1461686&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1486 Francesco Lai1, Chiara Sinico1, Alessandro De Logu2, Marco Zaru1, Rainer H Müller3, Anna M Fadda11Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Cagliari, Cagliari, Italy; 2Sezione di Microbiologia Medica, Dipartimento di Scienze e Tecnologie Biomediche, Università di Cagliari, Cagliari, Italy; 3Department of Pharmaceutical Technology, Biotechnology and Quality Management, The Free University of Berlin, Berlin, Germany Abstract: The effect of SLN incorporation on transdermal delivery and in vitro antiherpetic activity of Artemisia arborescens essential oil was investigated. Two different SLN formulations were prepared using the hot – pressure homogenization technique, Compritol 888 ATO as lipid, and Poloxamer 188 and Miranol Ultra C32 as surfac... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461686 Thu, 22 May 2008 16:54:23 +0100 1461686 http://www.medworm.com/index.php?rid=1461685&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1487 This article provides a review on the most commonly used nanoparticulate systems for gene delivery. We have discussed frequently used polymers, such as, polyethyleneimine, poly (lactide-co-glycolide), chitosan, as well as non-polymeric materials such as cationic lipids and metallic nanoparticles. The advantages and limitations of each system have been elaborated.Keywords: polynucleotides, gene delivery, gene therapy, transfection efficiency, polymers, liposomes (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461685 Thu, 22 May 2008 16:54:23 +0100 1461685 http://www.medworm.com/index.php?rid=1461684&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1488 Yvonne Hübner1, Kai F Hoettges1, Martin B McDonnell2, Michael J Carter3, Michael P Hughes11Centre for Biomedical Engineering, School of Engineering, University of Surrey, Guildford, Surrey UK; 2DSTL, Porton Down, Salisbury, Wiltshire, UK; 3School of Biomedical and Molecular Sciences, University of Surrey, Guildford, Surrey, UKAbstract: A major problem for surface-based detection techniques such as surface plasmon resonance and quartz crystal microbalances is that at low concentrations, diffusion is an insufficient driving force to bring colloidal submicron-scale particles to the detection surface. In order to overcome this, it has previously been demonstrated that a combination of dielectrophoresis and AC-electro-hydrodynamic flow can be used to focus cell-sized particles from suspens... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461684 Thu, 22 May 2008 16:54:23 +0100 1461684 http://www.medworm.com/index.php?rid=1461683&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1489 This study aims at verifying whether it is possible to control the architecture of the fiber meshes by tailoring the geometry of the collector. Three different metallic collector topographies are used to test this hypothesis. Electrospun nonwoven patterned meshes of polyethylene oxide (PEO) and poly(ε-caprolactone) (PCL) were successfully prepared. Those fiber meshes were analyzed by scanning electron microscopy (SEM). Both mechanical properties of the meshes and cell contacting experiments were performed to test the effect of the produced patterns over the properties of the meshes relevant for biomedical applications. The present study will evaluate cell adhesion sensitivity to the patterns generated and the effect of those patterns on the tensile properties of the fiber meshes.Ke... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461683 Thu, 22 May 2008 16:54:23 +0100 1461683 http://www.medworm.com/index.php?rid=1461682&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1490 Andrei M Popov1, Yurii E Lozovik1, Silvana Fiorito2,3, L’Hocine Yahia41Institute of Spectroscopy, Troitsk, Moscow region, 142190, Russia; 2Dept. of Experimental Medicine, University La Sapienza-CNR, Rome, Italy; 3Laboratoire des Colloides,Verres et Nanomateriaux, University of Montpellier II-CNRS, Montpellier, France; 4Laboratory for Innovation and Analysis of Bioperformances (LIAB), Biomedical Engineering Institute, Ecole Polytechnique de Montreal, CanadaAbstract: The set of nanoelectromechanical systems (NEMS) based on relative motion of carbon nanotubes walls is proposed for use in medical nanorobots. This set includes electromechanical nanothermometer, jet nanoengine, nanosyringe (the last can be used simultaneously as nanoprobe for individual biological molecules and drug nanode... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461682 Thu, 22 May 2008 16:54:23 +0100 1461682 http://www.medworm.com/index.php?rid=1461681&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1491 Evon Powell1, Y-H Lee2, Richard Partch1, Donn Dennis3, Timothy Morey3, Manoj Varshney31Department of Chemistry, Clarkson University, Potsdam, NY, USA; 2Department of Chemistry, Kyungwon University, Seoul, Korea; 3Department of Anesthesiology, University of Florida, Gainesville, FL, USA Abstract: The interaction of the important but often overdosed local anesthetic bupivacaine, its structural analogs 2,6-dimethylaniline, and N-methyl-2,6-dimethylacetanilide, and cocaine, with several electron deficient aromatic moieties were studied primarily by proton NMR and UV-visible spectroscopy. In solution, the anesthetic, its analogs and cocaine are electron donors and form π-π charge transfer complexes with strong aromatic acceptors, as monitored by the upfield changes induced in the NMR chem... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461681 Thu, 22 May 2008 16:54:23 +0100 1461681 http://www.medworm.com/index.php?rid=1461680&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1492 Jim Moselhy1, Swapna Sarkar1, Maria C Chia2, Joseph D Mocanu2, Nicolas Taulier1, Fei-Fei Liu2,3, Xiao Yu Wu11Leslie Dan Faculty of Pharmacy; University of Toronto, Toronto, Canada; 2Department of Medical Biophysics, University of Toronto, Toronto, Canada; 3Department of Radiation Oncology, Princess Margaret Hospital, Toronto, CanadaAbstract: Copolymers of 2-dimethyl(aminoethyl) methacrylate (PDMAEM) with N-isopropylacrylamide (NIPAM) were evaluated for their potential to enhance transgene expression of plasmid DNA (pDNA) and gene delivery by adenovirus vectors. The polymers of varying compositions and molecular weights (MW) were synthesized by free-radical polymerization. Polyelectrolyte complexes (PECs) were prepared with different charge (N:P) ratios of PNIPAM/DMAEM to pDNA. Polymer-modi... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461680 Thu, 22 May 2008 16:54:23 +0100 1461680 http://www.medworm.com/index.php?rid=1461679&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1494 Jianwu Xie1, Zhimin Shen2, King CP Li1,3, Narasimhan Danthi11Molecular Imaging Laboratory, Clinical Center and 2Vaccine Research Center, National Institutes of Health, Bethesda, MD, USA; 3Department of Radiology, The Methodist Hospital, Houston, TX, USAAbstract: Angiogenesis is an important process in cancer growth and metastasis. During the tumor angiogenic process, endothelial cells express various cell surface receptors which can be utilized for molecular imaging and targeted drug delivery. One such protein receptor of interest is the integrin αvβ3. Our group is involved in the development of molecular imaging probes and drug delivery systems targeting αvβ3. Based on extensive lead optimization study with the integrin antagonist compounds, we have developed a new g... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461679 Thu, 22 May 2008 16:54:23 +0100 1461679 http://www.medworm.com/index.php?rid=1461678&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1495 Matthew J DalbyCentre for Cell Engineering, Division of Infection and Immunity, Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow, UKAbstract: This review focuses on how cells respond to low-adhesion nanotopographies. In order to do this, fabrication techniques, how cells may locate nanofeatures through the use of filopodia and possible mechanotransductive mechanisms are discussed. From this, examples of low-adhesion topographies and sizes and arrangements that may lead to low-adhesion are discussed. Finally, it is hypothesized as to how specifically low-adhesion materials may fit into the outlined mechanotransductive mechanisms.Keywords: nanotopography, mechanotransduction, filopodia, nanofabrication (Source: International Journal of Nanomedi... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461678 Thu, 22 May 2008 16:54:23 +0100 1461678 http://www.medworm.com/index.php?rid=1461677&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1497 This study showed that nano-topography can be easily applied to Ti (through anodization) and porous PLGA (through NaOH chemical etching) to enhance osteoblast cell proliferation which may lead to better orthopedic implant performance. This straight forward application of nano-topography on current bone implant materials represents a new direction in the design of enhanced biomaterials for the orthopedic industry.Keywords: osseointegration, nano-scale topography, PLGA, titanium, tissue engineering, orthopedic implants (Source: International Journal of Nanomedicine) International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461677 Thu, 22 May 2008 16:54:23 +0100 1461677 http://www.medworm.com/index.php?rid=1461676&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1498 Efstathios Karathanasis1, Rohan Bhavane2, Ananth V Annapragada21Chemical Engineering Department, University of Houston, Houston, TX, USA; 2School of Health Informatics, University of Texas Health Science Center, Houston, TX, USAAbstract: In an attempt to achieve post-inhalation self-regulated insulin release, we constructed a microparticle agglomerate of nano-sized liposomal particles, with the agglomeration facilitated by cross-linkages capable of cleavage by glucose. The particles exhibited a small aerodynamic diameter within the human respirable range, but a large geometric diameter that prevents macrophage uptake and clearance. Upon intratracheal instillation of the “glucose-sensitive” microparticle into the lungs of rats, hyperglycemic events triggered an acceleration of t... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461676 Thu, 22 May 2008 16:54:23 +0100 1461676 http://www.medworm.com/index.php?rid=1461675&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1556 Li-Jiuan Shen, Fe-Lin Lin WuSchool of Pharmacy and Graduate Institute of Clinical Pharmacy, Department of Pharmacy at National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, TaiwanAbstract: Nanomedicine, known as the application of nanotechnology in medicine, has been applied to overcome the problems of poor bioavailability, in vitro and in vivo stability, and targeted delivery in the preparation of pharmaceutical products. Sirolimus, a water-insoluble immunosuppressant, has been formulated into an oral solid dosage form by using NanoCrystal® technology to increase the water solubility and thereby the bioavailability. The efficacy, safety, and pharmacokinetic properties are not significantly different between liquid and solid formulations except th... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461675 Thu, 22 May 2008 16:54:23 +0100 1461675 http://www.medworm.com/index.php?rid=1461674&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2815 Thomas J WebsterDivision of Engineering, Brown University, and Division of Orthopedic Surgery, Brown University Medical School, Providence, RI, USAIt is with great excitement that I welcome you to the International Journal of Nanomedicine (IJN). This new journal has been launched to bring you the latest, exciting, up-to-date research conducted at the intersection of nanotechnology and medicine. As you will see in this issue alone, researchers from around the world are actively pursuing numerous efforts to improve human health through nanotechnology; it is truly an international effort! A recent survey found that governmental nanotechnology programs were funding research worldwide up to an estimated US$5 billion (€3 billion) in 2004 alone (Wagner V and Zweck A 2005 September 30, pers c... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461674 Thu, 22 May 2008 16:54:23 +0100 1461674 http://www.medworm.com/index.php?rid=1461673&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2818 Thomas J WebsterDivisions of Engineering and Orthopedics, Brown University, Providence, RI, USAWelcome to the second issue of the International Journal of Nanomedicine (IJN)! Nanomedicine research is certainly international, as we try to emphasize in each and every issue of IJN. Over the next several issues, this editorial section will take a closer look at various aspects of international nanomedicine research. What a better place to start than its definition.Although defining a term such as nanomedicine may sound simple, by comparing several main funding agencies from around the world, one quickly realizes that a uniform international definition of nanomedicine does not currently exist. This is typical of a new field, but can be problematic to those trying to understand the field, make s... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461673 Thu, 22 May 2008 16:54:23 +0100 1461673 http://www.medworm.com/index.php?rid=1461672&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2819 Damon Sutton1,†, Saejeong Kim2,†, Xintao Shuai2, Konstantin Leskov1, Joao T Marques3, Bryan RG Williams3, David A Boothman1, Jinming Gao11Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA; 2Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA; 3Department of Cancer Biology, Cleveland Clinic Foundation, Cleveland, OH, USA; †These authors contributed equally to the workAbstract: Small interfering RNA molecules (siRNA) hold great promise to specifically target cytoprotective factors to enhance cancer therapy. Like antisense RNA strategies, however, the use of siRNA is limited because of in vivo instability. As a first step to overcome delivery issues, a series of graft copol... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461672 Thu, 22 May 2008 16:54:23 +0100 1461672 http://www.medworm.com/index.php?rid=1461671&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2820 Jin-oh You1, Yu-chuan Liu1, Ching-An PengThe Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, CA, USA; 1These authors contributed equally to this workAbstract: Reverse microemulsion was used as a template to fabricate chitosan–alginate core-shell nanoparticles encapsulated with enhanced green fluorescent protein (EGFP)-encoded plasmids. The average size of DNA-entrapped nanoparticles measured by dynamic light scattering was increased proportionally, with the N/P ratios ranging from 5 to 20. These alginate-coated chitosan nanoparticles endocytosed by NIH 3T3 cells trigged swelling of transport vesicles which render gene escape before entering digestive endolysosomal compartment and concomitantly promote gene transfec... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461671 Thu, 22 May 2008 16:54:23 +0100 1461671 http://www.medworm.com/index.php?rid=1461670&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2821 Viroj WiwanitkitDepartment of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandBlood gas analysis is a basic and useful laboratory test for the critical care of patients (Wiwanitkit 1999; Barthwal 2004). Arterial blood gas analysis is an essential investigation for assessing clinical oxygenation and acid-base status in critically ill patients (Wiwanitkit 1999; Barthwal 2004), providing information about ventilation, oxygenation, and acid-base status, the three closely interrelated physiological parameters that maintain pH homeostasis. The correct interpretation and application of arterial blood gas analysis requires knowledge of basic applied physiology in relation to these parameters (Wiwanitkit 1999; Barthwal 2004). Quality control of blood gas analysi... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461670 Thu, 22 May 2008 16:54:23 +0100 1461670 http://www.medworm.com/index.php?rid=1461669&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2837 Lester L Smith1, Paul J Niziolek2, Karen M Haberstroh1,3, Eric A Nauman1,4,5, Thomas J Webster1,31Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indianapolis, IN, USA; 2Indiana University School of Medicine, Indianapolis, IN, USA; 3Division of Engineering, Brown University, Providence, RI, USA, 4School of Mechanical Engineering, Purdue University, West Lafayette, Indianapolis, IN, USA; 5Department of Basic Medical Sciences, Purdue University, West Lafayette, Indianapolis, IN, USAAbstract: To facilitate locomotion and support the body, the skeleton relies on the transmission of forces between muscles and bones through complex junctions called entheses. The varying mechanical and biological properties of the enthesis make healing this avascular tissue difficult; ... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461669 Thu, 22 May 2008 16:54:23 +0100 1461669 http://www.medworm.com/index.php?rid=1461668&cid=s_36996_174_f&fid=36996&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2838 The objective of this in vitro study was to characterize osteoblast (bone-forming cell) adhesion on several potential orthopedic polymeric materials (specifically, polyetheretherketone, ultra-high molecular weight polyethylene, and polytetrafluoroethylene) coated with either titanium or gold using a novel Ionic Plasma Deposition process which creates a surface-engineered nanostructure (with features below 100 nm). Results demonstrated that compared to currently-used titanium and uncoated polymers, polymers coated with either titanium or gold using Ionic Plasma Deposition significantly increased osteoblast adhesion. Qualitative cell morphology results supported quantitative adhesion results as increased osteoblast cell spreading was observed on coated polymers compared to uncoated polymers.... International Journal of Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1461668 Thu, 22 May 2008 16:54:23 +0100 1461668