International Journal of Stroke via MedWorm.com MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'International Journal of Stroke' source. Wed, 08 Feb 2012 20:43:09 +0100 Intravenous alteplase in ischemic stroke patients not fully adhering to the current drug license in Central and Eastern Europe http://www.medworm.com/index.php?rid=5668637&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00733.x Conclusion Our findings show that patients not fully adhering to the European license are not at increased risk of symptomatic intracranial haemorrhage but achieve less favorable outcome. Some contraindications appear more redundant than others. However, the final conclusions about safety and effectiveness should be based on the results of ongoing randomized trials. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5668637 Tue, 07 Feb 2012 05:00:00 +0100 5668637 Hospital management and outcomes of stroke in Indigenous Australians: evidence from the 2009 Acute Care National Stroke Audit http://www.medworm.com/index.php?rid=5660857&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00717.x ConclusionsAustralian Indigenous patients with stroke received a reduced quality of care in hospitals and experienced worse outcomes than non‐Indigenous patients. Indigenous patients require the provision of evidence‐based care to increase their opportunities for optimal health outcomes following stroke. Further research to explain the differences is needed. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5660857 Thu, 02 Feb 2012 05:00:00 +0100 5660857 Transcranial laser therapy for acute ischemic stroke: a pooled analysis of NEST‐1 and NEST‐2 http://www.medworm.com/index.php?rid=5660856&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00754.x ConclusionsThis pooled analysis support the likelihood that transcranial laser therapy is effective for the treatment of acute ischemic stroke when initiated within 24 h of stroke onset. If ultimately confirmed, transcranial laser therapy will change management and improve outcomes of far more patients with acute ischemic stroke. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5660856 Thu, 02 Feb 2012 05:00:00 +0100 5660856 Lack of association between air pollutant exposure and short‐term risk of ischaemic stroke in Lyon, France http://www.medworm.com/index.php?rid=5668636&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00737.x ConclusionsThese results suggest a lack of association between air pollutant exposure and short‐term risk of ischaemic stroke in a French urban area. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5668636 Wed, 01 Feb 2012 05:00:00 +0100 5668636 PHANTOM‐S: the prehospital acute neurological therapy and optimization of medical care in stroke patients – study http://www.medworm.com/index.php?rid=5660855&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00756.x RationaleTime from symptom onset to treatment is closely associated with the effectiveness of intravenous thrombolysis in acute ischemic stroke patients. Hospitals are encouraged to take every effort to shorten delay of treatment. Despite combined efforts to streamline procedures in hospitals to provide treatment as soon as possible, most patients receive tissue plasminogen activator with considerable delay and very few of them within 90 mins. Germany has an internationally acknowledged prehospital emergency care system with specially trained doctors on ambulances. We developed an ambulance equipped with a Computed Tomography (CT) scanner, point‐of‐care laboratory, teleradiological support, and an emergency‐trained neurologist on board. In the Pre‐Hospital Acute Neurological Ther... International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5660855 Wed, 01 Feb 2012 05:00:00 +0100 5660855 Stent design lowers angiographic but not clinical adverse events in stenting of symptomatic intracranial stenosis – results of a single center study with 100 consecutive patients http://www.medworm.com/index.php?rid=5649956&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00715.x ConclusionDespite a high technical success, the rate of clinical adverse events at 30 days after intracranial angioplasty and stenting is high independently of the stent design. Thus, further development of intracranial stent systems and careful patient selection are mandatory. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5649956 Wed, 01 Feb 2012 05:00:00 +0100 5649956 A reappraisal of stroke mortality trends in Brazil (1979–2009) http://www.medworm.com/index.php?rid=5649955&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00757.x ConclusionStroke mortality rates are declining in Brazil for all stroke subtypes. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5649955 Wed, 01 Feb 2012 05:00:00 +0100 5649955 TESPI (Thrombolysis in Elderly Stroke Patients in Italy): a randomized controlled trial of alteplase (rt‐PA) versus standard treatment in acute ischaemic stroke in patients aged more than 80 years where thrombolysis is initiated within three hours after stroke onset http://www.medworm.com/index.php?rid=5649957&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00747.x This article describes the design of the Thrombolysis in Elderly Stroke Patients in Italy (TESPI) trial planned to fill the lack of controlled data on i.v. thrombolysis in this age category of stroke patients.AimsTo collect efficacy and safety data on i.v. alteplase (rt‐PA) in patients aged more than 80 years, to demonstrate that the treatment of these patients within three hours of symptoms onset of an acute ischaemic stroke with i.v. rt‐PA, compared to patients receiving standard treatment (according to the national guidelines), will result in an improved clinical outcome with a favourable benefit/risk ratio.DesignTESPI is a prospective, multicenter, national, open‐label, controlled (non‐treated group as control), randomized, parallel group trial with blinded evaluation of outcom... International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5649957 Tue, 31 Jan 2012 05:00:00 +0100 5649957 Acknowledgement of reviewers http://www.medworm.com/index.php?rid=5610960&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00769.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5610960 Sat, 21 Jan 2012 00:38:20 +0100 5610960 Transient ischemic attack: the ‘waste basket’ http://www.medworm.com/index.php?rid=5610959&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00742.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5610959 Sat, 21 Jan 2012 00:38:19 +0100 5610959 Plasma biomarker may help to distinguish acute CVST from non‐thrombotic CVSS in emergency http://www.medworm.com/index.php?rid=5610958&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00746.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5610958 Sat, 21 Jan 2012 00:38:17 +0100 5610958 The Rankin scale with revised structured interview: effect on reliability, grading of disability and detection of dementia http://www.medworm.com/index.php?rid=5610957&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00743.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5610957 Sat, 21 Jan 2012 00:38:15 +0100 5610957 Benefits of early tracheostomy in ventilated stroke patients? Current evidence and study protocol of the randomized pilot trial SETPOINT (Stroke‐related Early Tracheostomy vs. Prolonged Orotracheal Intubation in Neurocritical care Trial) http://www.medworm.com/index.php?rid=5610956&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00703.x DiscussionTo clarify the potential benefit of early tracheostomy in critical care ventilated stroke patients, a randomized multicenter trial in a larger patient population is clearly needed. If this monocentric pilot gives promising safety, feasibility, and benefit results, such a multicenter trial will be planned. The results will have a relevant direct impact on the critical care of stroke. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5610956 Sat, 21 Jan 2012 00:38:13 +0100 5610956 Cooling in intracerebral hemorrhage (CINCH) trial: protocol of a randomized German–Austrian clinical trial http://www.medworm.com/index.php?rid=5610955&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00707.x ConclusionThe results of Cooling in IntraCerebral Hemorrhage trial are believed to directly influence future therapy of large intracerebral hemorrhage. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5610955 Sat, 21 Jan 2012 00:38:12 +0100 5610955 Burden of stroke in Malaysia http://www.medworm.com/index.php?rid=5610954&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00767.x Stroke is one of the top five leading causes of death and one of the top 10 causes for hospitalization in Malaysia. Stroke is also in the top five diseases with the greatest burden of disease, based on disability‐adjusted life years. However, prospective studies on stroke in Malaysia are limited. To date, neither the prevalence of stroke nor its incidence nationally has been recorded. Hypertension is the major risk factor for stroke. The mean age of stroke patients in Malaysia is between 54·5 and 62·6 years. Traditional medicine is commonly practiced. With the increasing number of stroke cases annually, more government and nongovernment organizations should be involved in primary and secondary prevention strategies. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5610954 Sat, 21 Jan 2012 00:38:10 +0100 5610954 Fatigue after stroke: a systematic review of associations with impaired physical fitness http://www.medworm.com/index.php?rid=5610953&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00741.x ConclusionsThere is very limited evidence regarding associations between exercise, fitness, and fatigue after stroke. It still remains highly plausible that exercise can have a positive influence on fatigue. Future research should be longitudinal in design. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5610953 Sat, 21 Jan 2012 00:38:07 +0100 5610953 Systematic review and meta‐analysis of the efficacy of statins in experimental stroke http://www.medworm.com/index.php?rid=5610952&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00740.x ConclusionsThese findings suggest that statins administered after middle cerebral artery occlusion have modest efficacy. Effects of potential sources of bias are considered likely to reduce the estimated effect from this review. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5610952 Sat, 21 Jan 2012 00:38:05 +0100 5610952 Risks and benefits of thrombolysis in the elderly http://www.medworm.com/index.php?rid=5610951&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00744.x ConclusionWe feel that carefully selected patients who meet eligibility criteria for thrombolysis should not be denied this therapy on the basis of age alone. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5610951 Sat, 21 Jan 2012 00:38:03 +0100 5610951 The king is dead (warfarin): direct thrombin and factor Xa inhibitors: the next Diadochian War? http://www.medworm.com/index.php?rid=5610950&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00739.x Atrial fibrillation is an important risk factor for stroke. New drugs for oral anticoagulation that do not exhibit the limitations of vitamin K antagonists like warfarin are under investigation. These include direct factor Xa inhibitors and direct thrombin‐inhibitors. Recent studies provide promising results for apixaban, dabigatran, and rivaroxaban, including higher efficacy and significantly lower incidences of intracranial bleeds compared with warfarin. The new oral anticoagulants substances show similar results in secondary as in primary stroke prevention in patients with AF and will on the long run replace warfarin. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5610950 Sat, 21 Jan 2012 00:38:01 +0100 5610950 Development, expansion, and use of a stroke clinical trials resource for novel exploratory analyses http://www.medworm.com/index.php?rid=5610949&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00735.x ConclusionsApplication of the original Virtual International Stroke Trials Archive concepts beyond acute stroke trials can extend the value of clinical research at low cost, without threatening commercial or intellectual property interests. This delivers valuable research output to inform the efficiency of future stroke research. We invite stroke researchers to participate actively in Virtual International Stroke Trials Archive and encourage the extension of Virtual International Stroke Trials Archive principles to other disease areas. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5610949 Sat, 21 Jan 2012 00:38:00 +0100 5610949 Higher carotid intima media thickness predicts extracranial vascular events and not stroke recurrence among transient ischemic attack patients http://www.medworm.com/index.php?rid=5610948&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00764.x ConclusionsAn elevated common carotid artery intima‐media thickness value was associated with a higher long‐term risk of extracranial vascular events but no with stroke recurrence. Hypercholesterolemia was the main risk factor for extracranial vascular events. The combination of hypercholesterolemia and common carotid artery intima‐media thickness >0·939 mm justify the establishment of aggressive therapies and the study of subclinical coronary heart disease and peripheral arterial disease. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5610948 Sat, 21 Jan 2012 00:37:58 +0100 5610948 Why should you support the WSO? http://www.medworm.com/index.php?rid=5610947&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00768.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5610947 Sat, 21 Jan 2012 00:37:51 +0100 5610947 Fabry's disease: A prospective multicenter cohort study in young adults with cryptogenic stroke http://www.medworm.com/index.php?rid=5610942&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00734.x ConclusionThis study constitutes the first initiative to determine the prevalence of a positive screen for Fabry's disease in young adults with stroke in Canada. Moreover, the Canadian Fabry Stroke Screening Initiative will provide information on recurrent vascular events, disability at six‐months (modified Rankin scale), and disposition in this understudied population. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5610942 Sat, 21 Jan 2012 00:36:49 +0100 5610942 Safety and feasibility of NeuroFlo use in eight‐ to 24‐hour ischemic stroke patients http://www.medworm.com/index.php?rid=5610946&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00719.x ConclusionsPartial aortic occlusion using the NeuroFlo catheter, a novel collateral therapeutic strategy, appears safe and feasible in stroke patients eight‐hours to 24 h after symptom onset. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5610946 Fri, 20 Jan 2012 05:00:00 +0100 5610946 Translating the use of an enriched environment poststroke from bench to bedside: study design and protocol used to test the feasibility of environmental enrichment on stroke patients in rehabilitation http://www.medworm.com/index.php?rid=5610945&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00727.x RationaleEnvironmental enrichment, a paradigm investigated extensively in animal models, is an intervention, which by design facilitates motor, sensory, social, and cognitive activity. It has been shown to improve poststroke motor and cognitive function in animal models of stroke. This is the first study to attempt to translate this intervention from the laboratory to the clinical setting.AimsThe overall aim of this pilot study is to test the feasibility of using environmental enrichment with stroke patients in a rehabilitation setting. The aim is to enrich the environment of stroke survivors in a rehabilitation ward and measure changes in their activity (physical, cognitive, and social activity).DesignProspective nonrandomized block design intervention study.StudyIn the control phase we w... International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5610945 Fri, 20 Jan 2012 05:00:00 +0100 5610945 Assessing the impact of thrombolysis on progress through inpatient rehabilitation after stroke: a multivariable approach http://www.medworm.com/index.php?rid=5610944&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00729.x ConclusionResults suggest that tissue plasminogen activator may contribute to accelerated progress through inpatient rehabilitation; however, there is no evidence to suggest that it contributes to greater functional improvement as measured by the Functional Independence Measure. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5610944 Fri, 20 Jan 2012 05:00:00 +0100 5610944 The association between depression, suicidal ideation, and stroke in a population‐based sample http://www.medworm.com/index.php?rid=5610943&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00702.x ConclusionsRegular screening for depression and suicidal ideation is important for stroke survivors, particularly those with substantial physical limitations. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5610943 Fri, 20 Jan 2012 05:00:00 +0100 5610943 The relation between chronic kidney disease and cerebral microbleeds: difference between patients with and without diabetes http://www.medworm.com/index.php?rid=5599255&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00732.x Conclusion We found that chronic kidney disease is independently associated with cerebral microbleeds in patients without diabetes but not in patients with diabetes. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5599255 Sun, 01 Jan 2012 05:00:00 +0100 5599255 Corrigendum http://www.medworm.com/index.php?rid=5526911&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00745.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5526911 Thu, 22 Dec 2011 13:07:57 +0100 5526911 Development of stroke care in the southern coastal district of India http://www.medworm.com/index.php?rid=5526910&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00713.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5526910 Thu, 22 Dec 2011 13:07:55 +0100 5526910 Psychosocial problems, quality of life, and caregiver burden among stroke caregivers in India http://www.medworm.com/index.php?rid=5526909&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00721.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5526909 Thu, 22 Dec 2011 13:07:53 +0100 5526909 Is air pollution a risk factor for stroke? http://www.medworm.com/index.php?rid=5526908&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00720.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5526908 Thu, 22 Dec 2011 13:07:52 +0100 5526908 A multicentre, randomized, double‐blinded, placebo‐controlled Phase III study to investigate EXtending the time for Thrombolysis in Emergency Neurological Deficits (EXTEND) http://www.medworm.com/index.php?rid=5526907&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00730.x Background and hypothesisThrombolytic therapy with tissue plasminogen activator is effective for acute ischaemic stroke within 4·5 h of onset. Patients who wake up with stroke are generally ineligible for stroke thrombolysis. We hypothesized that ischaemic stroke patients with significant penumbral mismatch on either magnetic resonance imaging or computer tomography at three‐ (or 4·5 depending on local guidelines) to nine‐hours from stroke onset, or patients with wake‐up stroke within nine‐hours from midpoint of sleep duration, would have improved clinical outcomes when given tissue plasminogen activator compared to placebo.Study designEXtending the time for Thrombolysis in Emergency Neurological Deficits is an investigator‐driven, Phase III, randomized, multicentre, double... International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5526907 Thu, 22 Dec 2011 13:07:45 +0100 5526907 Dementia, stroke, and vascular risk factors; a review http://www.medworm.com/index.php?rid=5526906&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00731.x Interest in dementia has increased over the past few decades. Stroke is an important cause of cognitive problems. The term vascular cognitive impairment is now used to describe dementia attributed to stroke or deep white matter lesions detected on imaging. Although vascular cognitive impairment is increasingly diagnosed, Alzheimer's disease remains the most common dementia worldwide. The relationship between Alzheimer's disease and vascular cognitive impairment is unclear, although there exists significant overlap, which prompts physicians to consider them opposite ends of a disease spectrum, rather than separate entities. There is also substantial evidence that stroke risk factors such as hypertension, diabetes; lipid disorders, etc. are independently associated with an increased risk of ... International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5526906 Thu, 22 Dec 2011 13:07:44 +0100 5526906 Stem cells and stroke: are we further away than anyone is willing to admit? http://www.medworm.com/index.php?rid=5526905&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00724.x Harnessing the potential of stem cells or other types of cell therapies to regenerate brain tissue lost from a stroke is a long way off, and a far more complicated process than is understood. There are critical safety issues regarding stem cells in stroke and many clinical trials have only just begun. We are at least 5–10 years away from knowing if cell therapies will improve clinical outcome in stroke patients. The use of stem cells in stroke therapy remains investigational only. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5526905 Thu, 22 Dec 2011 13:07:39 +0100 5526905 Negative results: why do they need to be published? http://www.medworm.com/index.php?rid=5526904&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00723.x This short narrative review article defines ‘negative results’ and cites several ethical and scientific reasons why such studies should be made publicly available. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5526904 Thu, 22 Dec 2011 13:07:37 +0100 5526904 Seven years of IJS and working hard to meet the needs of stroke professionals globally http://www.medworm.com/index.php?rid=5526903&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00738.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5526903 Thu, 22 Dec 2011 13:07:27 +0100 5526903 The effectiveness of thrombolysis with intravenous alteplase for acute ischemic stroke in daily practice http://www.medworm.com/index.php?rid=5506697&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00709.x ConclusionsThrombolysis for ischemic stroke with intravenous alteplase is an effective treatment also in an unselected observational cohort of patients. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5506697 Wed, 14 Dec 2011 05:00:00 +0100 5506697 Use of oral anticoagulation among stroke patients with atrial fibrillation in China: the ChinaQUEST (Quality evaluation of stroke care and treatment) registry study http://www.medworm.com/index.php?rid=5506696&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00716.x ConclusionsThese data indicate oral anticoagulation use is lower in stroke patients with atrial fibrillation in China than that in Western countries, being applied more often in those of younger age, nonmanual occupation, and having less cardiovascular risk factors. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5506696 Wed, 14 Dec 2011 05:00:00 +0100 5506696 SPREAD‐STACI study: A protocol for a randomized multicenter clinical trial comparing urgent with delayed endarterectomy in symptomatic carotid artery stenosis http://www.medworm.com/index.php?rid=5488385&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00699.x RationaleIn patients with >50% carotid artery stenosis (as measured by North American Symptomatic Carotid Endarterectomy Trial (NASCET) criteria) suffering a transient ischemic attack or a minor ipsilateral stroke, carotid endarterectomy exerts maximum benefits, when performed within the first 15 days from the initial ischemic symptom. It is also known that the probability of a major stroke spikes within the first few days after a transient ischemic attack/minor stroke and then flattens out in the following days and weeks. It could be hypothesized that urgent carotid endarterectomy has greater benefit than delayed procedure.AimsDemonstrate that urgent carotid endarterectomy is more effective than delayed interventions.DesignCenters employing neurolgist/stroke physicians and vascular s... International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5488385 Thu, 08 Dec 2011 05:00:00 +0100 5488385 Knowledge of stroke risk factors and warning signs in Ireland: development and application of the Stroke Awareness Questionnaire (SAQ) http://www.medworm.com/index.php?rid=5488384&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00698.x ConclusionsSurvey findings provide first evidence on levels of knowledge of stroke risk factors and warning signs in the Irish adult population. Awareness of stroke warning signs was poor, as was awareness of the need to call emergency services and the potential for acute stroke intervention. These factors contribute to delay in seeking medical attention following stroke, with resulting implications for stroke outcome. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5488384 Thu, 08 Dec 2011 05:00:00 +0100 5488384 Trends in the hospitalization of ischemic stroke in the United States, 1998–2007 http://www.medworm.com/index.php?rid=5488383&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00700.x ConclusionIn 1998 through to 2007, the overall rate of ischemic stroke hospitalization in the United States decreased. However, rates among young adults increased. In‐hospital mortality rates decreased over the study period. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5488383 Thu, 08 Dec 2011 05:00:00 +0100 5488383 The SWIFT Cast trial protocol: a randomized controlled evaluation of the efficacy of an ankle–foot cast on walking recovery early after stroke and the neural–biomechanical correlates of response http://www.medworm.com/index.php?rid=5488382&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00704.x RationaleAn ankle–foot cast may enable people to repeatedly practice walking with a more normal movement pattern early after stroke.AimsTo evaluate the clinical efficacy of using an ankle–foot cast [soft scotch ankle‐foot (SWIFT) Cast] to enhance walking recovery and to find whether site of stroke lesion and/or baseline biomechanical characteristics predict response to a SWIFT Cast.DesignRandomized, controlled, observer‐blind trial.StudyParticipants (n = 120), 3–42 days after stroke with walking difficulty. All will receive conventional physical therapy. Those allocated to the experimental group will also receive a SWIFT Cast for up to six‐weeks. During therapy sessions, the SWIFT Cast will be worn for retraining of walking as clinically appropriate. Outside therapy session... International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5488382 Thu, 08 Dec 2011 05:00:00 +0100 5488382 MRI in patients with acute basilar artery occlusion – DWI lesion scoring is an independent predictor of outcome http://www.medworm.com/index.php?rid=5488381&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00705.x ConclusionIn patients with acute basilar artery occlusion, posterior circulation Acute Stroke Prognosis Early CT Score of 8 or more points on early diffusion weighted imaging is an independent predictor for favorable outcome. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5488381 Thu, 08 Dec 2011 05:00:00 +0100 5488381 Comparison of cardiovascular risk factors and survival in patients with ischemic or hemorrhagic stroke http://www.medworm.com/index.php?rid=5488380&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00706.x ConclusionsPatients with hemorrhagic stroke had a higher risk of dying within the first 30 days after stroke, but the risk of death was similar in the two groups after one‐month. Hypertension was the only cardiovascular disease risk factor associated with an increased mortality rate for hemorrhagic stroke as compared to ischemic stroke. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5488380 Thu, 08 Dec 2011 05:00:00 +0100 5488380 The association between major depression, health behaviors, and quality of life in adults with stroke http://www.medworm.com/index.php?rid=5488379&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00708.x ConclusionsIn adults with stroke, major depression is associated with decreased engagement in stroke‐specific and gender‐specific self‐care and preventive health behaviors, as well as a broad range of quality of life indices. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5488379 Thu, 08 Dec 2011 05:00:00 +0100 5488379 Does acute behavioral testing reflect successful ischemia in rats with transient middle cerebral artery occlusion? http://www.medworm.com/index.php?rid=5488378&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00710.x ConclusionsAcute behavioral testing performed during arterial occlusion fails to identify successfully operated animals. Acute diffusion magnetic resonance imaging may be more appropriate to assess and reduce infarct size variability in this model. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5488378 Thu, 08 Dec 2011 05:00:00 +0100 5488378 Factors associated with severity on admission and in‐hospital mortality after primary intracerebral hemorrhage in China http://www.medworm.com/index.php?rid=5488377&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00712.x ConclusionGlasgow Coma Scale score and hematoma locations were independently associated with severity on admission and in‐hospital mortality after primary intracerebral hemorrhage. The study also highlights the deleterious effect of comorbidities on in‐hospital mortality following primary intracerebral hemorrhage in China. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5488377 Thu, 08 Dec 2011 05:00:00 +0100 5488377 Low bone mineral density is associated with poor clinical outcome in acute ischemic stroke http://www.medworm.com/index.php?rid=5488376&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00714.x ConclusionsLow bone mineral density of the right femur in the acute poststroke period is associated with poor outcome at three‐months. Assessment of bone mineral density in acute stroke patients may be a useful prognosticator and facilitate early intervention. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5488376 Thu, 08 Dec 2011 05:00:00 +0100 5488376 Hemorrhage after ischemic stroke – relation to age and previous hemorrhage in a nationwide cohort of 58 868 patients http://www.medworm.com/index.php?rid=5506695&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00718.x ConclusionsWhen antithrombotics were used in large‐scale clinical practice, the observed rates of hemorrhage were similar with anticoagulant therapy but increased with antiplatelet therapy compared with rates reported in randomized controlled trials. Old age and previous hemorrhage were associated with an increased risk of hemorrhage after an ischemic stroke. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5506695 Thu, 01 Dec 2011 05:00:00 +0100 5506695 Association of laterality and size of perfusion lesions on neurological deficit in acute supratentorial stroke http://www.medworm.com/index.php?rid=5488375&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00726.x ConclusionsLarger perfusion defects contribute to higher scores on the total and most individual items of the National Institutes of Health Stroke Scale. However, lesion laterality contributes substantially to half the item scores, with greater association of left than right‐brain side. These findings indicate that imaging‐deficit correlations will be improved by designating lesions into an atlas, taking into account side in addition to size. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5488375 Thu, 01 Dec 2011 05:00:00 +0100 5488375 Conference diary http://www.medworm.com/index.php?rid=5442941&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00711.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5442941 Fri, 25 Nov 2011 13:09:58 +0100 5442941 Prior anticoagulant therapy, subtherapeutic international normalized ratio and thrombolytic therapy in acute ischemic stroke http://www.medworm.com/index.php?rid=5442940&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00669.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5442940 Fri, 25 Nov 2011 13:09:57 +0100 5442940 Inflammation, poststroke depression and statins http://www.medworm.com/index.php?rid=5442939&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00691.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5442939 Fri, 25 Nov 2011 13:09:55 +0100 5442939 Should oral glucose tolerance test be routinely performed for patients with symptomatic cerebrovascular diseases? http://www.medworm.com/index.php?rid=5442938&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00693.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5442938 Fri, 25 Nov 2011 13:09:54 +0100 5442938 Study design presentation: suggestion for further improvement http://www.medworm.com/index.php?rid=5442937&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00633.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5442937 Fri, 25 Nov 2011 13:09:52 +0100 5442937 Circuit class or seven‐day therapy for increasing intensity of rehabilitation after stroke: protocol of the CIRCIT trial http://www.medworm.com/index.php?rid=5442936&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00686.x Rationale There is strong evidence for a dose–response relationship between physical therapy early after stroke and recovery of function. The optimal method of maximizing physical therapy within finite health care resources is unknown.Aims To determine the effectiveness and cost‐effectiveness of two alternative models of physical therapy service delivery (seven‐days per week therapy services or group circuit class therapy over five‐days a week) to usual care for people receiving inpatient rehabilitation after stroke.Design Multicenter, three‐armed randomized controlled trial with blinded assessment of outcomes.Study A total of 282 people admitted to inpatient rehabilitation facilities after stroke with an admission functional independence measure (FIM) sco... International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5442936 Fri, 25 Nov 2011 13:09:51 +0100 5442936 Brain aging, cognition in youth and old age and vascular disease in the Lothian Birth Cohort 1936: rationale, design and methodology of the imaging protocol* http://www.medworm.com/index.php?rid=5442935&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00683.x This study aims to characterize changes in brain structure in old age, and to investigate relationships between brain aging and cognitive decline using the Lothian Birth Cohort 1936. Here, we report the rationale, design and methodology of the brain and neurovascular imaging protocol developed to study this cohort.Design An observational, longitudinal study of the Lothian Birth Cohort 1936, which comprises 1091 relatively healthy individuals now in their 70s and living in the Edinburgh area. They are surviving participants of the Scottish Mental Survey 1947, which involved a test of general intelligence taken at age 11 years. At age 70 years, the Lothian Birth Cohort 1936 undertook detailed cognitive, medical and genetic testing, and provided social, family, nutritional, quality of l... International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5442935 Fri, 25 Nov 2011 13:09:49 +0100 5442935 Computed tomography perfusion prognostic maps do not predict reversible and irreversible neurological dysfunction following reperfusion therapies http://www.medworm.com/index.php?rid=5442934&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00681.x Conclusions In‐patients achieving early and complete reperfusion, pretreatment CTP prognostic maps were not predictive for irreversibly or reversibly lost neurologic functions. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5442934 Fri, 25 Nov 2011 13:09:47 +0100 5442934 Alternative therapies for stroke treatment in Asia http://www.medworm.com/index.php?rid=5442933&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00680.x Patients seek alternative therapies for stroke in Asia due to dissatisfaction with poststroke recovery. Most alternative therapies are of unproven benefit in rehabilitation. Well‐conducted trials are needed to better define the role of alternative therapies in the process of poststroke recovery; the CHInese Medicine Neuroaid Efficacy on Stroke recovery is ongoing. However, further studies, better health education and rehabilitation services and centers are also required. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5442933 Fri, 25 Nov 2011 13:09:45 +0100 5442933 What is the probability of patients who are nonambulatory after stroke regaining independent walking? A systematic review http://www.medworm.com/index.php?rid=5442932&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00668.x Patients after stroke who are nonambulatory require resources, and independent walking becomes a major determinant of the ability to participate in activities of daily living. Our objective was to determine the probability of walking for patients who are nonambulatory in the first month after stroke. We performed a systematic review and meta‐analysis of consecutive, prospective studies of nonambulatory patients within the first month after stroke in rehabilitation and acute units. The outcomes were the probability of achieving independent walking at three‐, six‐ and 12 months after stroke. Twenty‐six studies were included in the review. Seventeen studies comprising 2856 participants were entered into meta‐analyses. For initially nonambulatory stroke patients managed in a rehabili... International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5442932 Fri, 25 Nov 2011 13:09:44 +0100 5442932 Current status of intravenous thrombolysis for acute ischemic stroke in Asia http://www.medworm.com/index.php?rid=5442931&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00671.x Conclusions Variable dose regimens of IV‐tPA are used across Asia without any reliable or established evidence. Establishing a uniform IV‐tPA regimen is essential since the rapid improvements in health‐care facilities and public awareness are expected to increase the rates of thrombolysis in Asia. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5442931 Fri, 25 Nov 2011 13:09:42 +0100 5442931 Endovascular treatment strategies for acute ischemic stroke http://www.medworm.com/index.php?rid=5442930&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00670.x The limitations of intravenous thrombolysis therapy have paved the way for the development of novel endovascular technologies for use in the setting of acute stroke. These technologies range from direct intraarterial thrombolysis to various thrombus disruption or retrieval devices to angioplasty and stenting. The tools in the armamentarium of the neuroendovascular interventionalist enable fast, effective revascularization to be offered to a wider population of patients that may otherwise have few therapeutic options available to them. In this paper, we review the current state‐of‐the‐art in neuroendovascular intervention for acute ischemic stroke. Particular emphasis is placed on delineating the indications and outcomes for use of these various technologies. (Source: International Jo... International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5442930 Fri, 25 Nov 2011 13:09:40 +0100 5442930 Tenecteplase for acute ischemic stroke http://www.medworm.com/index.php?rid=5442929&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00695.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5442929 Fri, 25 Nov 2011 13:09:39 +0100 5442929 Physical fitness training after stroke, time to implement what we know: more research is needed http://www.medworm.com/index.php?rid=5442928&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00679.x Stroke survivors experience marked reduction in physical activity and fitness. Regular physical fitness training, started early poststroke, could help recovery in the long term and is recommended in many clinical guidelines. However, implementation of programs is hampered by our current lack of knowledge about what interventions are most effective and how best to support stroke survivors to exercise. In the United Kingdom and Australia, there are educational programs for exercise professionals to enable them to safely and effectively deliver exercise to stroke survivors; and in the United Kingdom, community exercise training programs are being developed to follow‐on from usual rehabilitation. As with many areas of life after stroke, further research is still needed. We need to know more ... International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5442928 Fri, 25 Nov 2011 13:09:37 +0100 5442928 Absence of cerebral microbleeds predicts reversion of vascular ‘cognitive impairment no dementia’ in stroke http://www.medworm.com/index.php?rid=5442927&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00682.x Conclusions The results suggest that the absence of cerebral microbleeds may be associated with a higher likelihood of a reversible cognitive impairment in stroke patients. The mechanism of how this occurs is not well understood. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5442927 Fri, 25 Nov 2011 13:09:35 +0100 5442927 Increasing editions from six to eight in 2012 http://www.medworm.com/index.php?rid=5442926&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00689.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5442926 Fri, 25 Nov 2011 13:09:26 +0100 5442926 Effects of lower limb reciprocal pedalling exercise on motor function after stroke: a systematic review of randomized and nonrandomized studies http://www.medworm.com/index.php?rid=5442922&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00728.x This review systematically synthesized current evidence on the effects of lower limb reciprocal pedalling exercise on motor function poststroke. Detailed analysis of single studies in the review revealed multiple instances of heterogeneity including outcome measures; therefore we decided to avoid undertaking a single, potentially misleading meta‐analysis. We found that despite beneficial (although nondefinitive) effects on balance, functional independence, and muscle strength, it is not possible to make clinical recommendations that support or refute the use of reciprocal pedalling exercise to enhance recovery of motor function after stroke. Our findings provide proof‐of‐concept for pedalling interventions and provide a foundation for subsequent research, suggesting a need for furthe... International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5442922 Fri, 25 Nov 2011 13:08:35 +0100 5442922 Impact of anticoagulation before stroke on stroke severity and long‐term survival http://www.medworm.com/index.php?rid=5442925&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00672.x ConclusionsIn patients in which atrial fibrillation was diagnosed prior to the index stroke, about 23% received anticoagulation according to guideline recommendations. Therapeutic anticoagulation at stroke onset significantly decreased the risk of moderate to severe stroke on admission but showed no significant association with long‐term survival. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5442925 Thu, 24 Nov 2011 05:00:00 +0100 5442925 A cluster randomized controlled trial of a structured training programme for caregivers of inpatients after stroke (TRACS) http://www.medworm.com/index.php?rid=5442924&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00722.x RationaleThe majority of stroke patients are discharged home dependent on informal caregivers, usually family members, to provide assistance with activities of daily living, including bathing, dressing, and toileting. Many caregivers feel unprepared for this role, and this may have a detrimental effect on both the patient and caregiver.AimsTo evaluate whether a structured, competency‐based training programme for caregivers improves physical and psychological outcomes for patients and their caregivers after disabling stroke, and to determine if such a training programme is cost‐effective.DesignA cluster randomized controlled trial. The trial aims to recruit 25 patient and caregiver dyads from each of the 36 participating stroke rehabilitation units. Stroke units have been randomized to ... International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5442924 Thu, 24 Nov 2011 05:00:00 +0100 5442924 Cerebral small vessel disease: a review of clinical, radiological, and histopathological phenotypes http://www.medworm.com/index.php?rid=5442923&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00725.x Cerebral small vessel disease is difficult to directly visualize in vivo. Therefore, we rely on radiological phenotypes as surrogate markers of disease. The principal phenotypes of clinical interest are small, deep brain infarcts, cerebral white matter lesions, deep brain haemorrhages, and cerebral microbleeds. The causes or mechanisms underlying these phenotypes are understood in varying degrees of detail. This review aims to summarize recent knowledge regarding these phenotypes and place it in context with classical clinicopathological observations to provide mechanistic, clinical, and therapeutic insights into small vessel disease. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5442923 Thu, 24 Nov 2011 05:00:00 +0100 5442923 Underuse of antithrombotic therapy caused high incidence of ischemic stroke in patients with atrial fibrillation http://www.medworm.com/index.php?rid=5432829&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00667.x ConclusionsIt is important in prevention of ischemic stroke to give antithrombotic therapy to newly diagnosed atrial fibrillation patients. Underuse of antithrombotic therapy and warfarin were more severe in our study than in Western countries. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5432829 Tue, 22 Nov 2011 05:00:00 +0100 5432829 Value of measuring serum vascular endothelial growth factor levels in diagnosing acute ischemic stroke http://www.medworm.com/index.php?rid=5432828&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00677.x ConclusionsVascular endothelial growth factor has limited clinical utility in the diagnosis of acute ischemic stroke in the emergency room because levels are also raised in common stroke mimics. Further studies are required to establish the mechanism of vascular endothelial growth factor elevation in postictal paresis. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5432828 Tue, 22 Nov 2011 05:00:00 +0100 5432828 Randomized comparison of synchronous CABG and carotid endarterectomy vs. isolated CABG in patients with asymptomatic carotid stenosis: The CABACS trial http://www.medworm.com/index.php?rid=5432827&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00687.x The objective of this study is to compare the safety and efficacy of isolated coronary artery bypass grafting vs. synchronous coronary artery bypass grafting and carotid endarterectomy in patients with asymptomatic high‐grade carotid artery stenosis.DesignCoronary Artery Bypass graft surgery in patients with Asymptomatic Carotid Stenosis (CABACS) is a randomized, controlled, open, multicenter, group sequential trial with two parallel arms and outcome adjudication by blinded observers. Patients with asymptomatic high‐grade carotid stenosis scheduled for elective coronary artery bypass grafting will be assigned to either isolated coronary artery bypass grafting or synchronous coronary artery bypass grafting and carotid endarterectomy by 1 : 1 block‐stratified randomization with thr... International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5432827 Tue, 22 Nov 2011 05:00:00 +0100 5432827 Clinical utility of the AlphaFIM® instrument in stroke rehabilitation http://www.medworm.com/index.php?rid=5432826&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00694.x ConclusionsThe AlphaFIM instrument is a valuable tool for triaging stroke patients from acute care to rehabilitation and predicts functional status at discharge from rehabilitation. Patients with low AlphaFIM ratings have the potential to make significant functional gains and should not be denied admission to inpatient rehabilitation programs. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5432826 Tue, 22 Nov 2011 05:00:00 +0100 5432826 Too good to treat? Outcomes in patients not receiving thrombolysis due to mild deficits or rapidly improving symptoms http://www.medworm.com/index.php?rid=5432825&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00696.x ConclusionWe found that a small proportion of patients deemed too good to treat will have early neurological deterioration, in contrast to other studies. Decisions about whether to treat mild stroke patients depend on the outcome measure chosen, particularly when considering discharge disposition among patients who have had prior stroke. The decision to thrombolyze may ultimately rest on the nature of the presentation and deficit. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5432825 Tue, 22 Nov 2011 05:00:00 +0100 5432825 Layperson‐oriented vs. clinical‐based models for prediction of incidence of ischemic stroke: National FINRISKStudy http://www.medworm.com/index.php?rid=5365281&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00692.x ConclusionsThe layperson model performed as well as the clinical‐based one. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5365281 Wed, 02 Nov 2011 04:00:00 +0100 5365281 Predictors for poststroke outcomes: the Tel Aviv Brain Acute Stroke Cohort (TABASCO) study protocol http://www.medworm.com/index.php?rid=5365280&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00652.x This study is an attempt to comprehensively investigate the long‐term outcome of mild–moderate strokes. Its prospective design will provide quantitative data on stroke recurrence, the incidence of other vascular events and the evaluation of cognitive, affective and functional decline. Identifying the factors associated with poststroke cognitive and functional decline could potentially yield more effective therapeutic approaches. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5365280 Wed, 02 Nov 2011 04:00:00 +0100 5365280 Cerebral venous thrombosis in inflammatory bowel diseases: eight cases and literature review http://www.medworm.com/index.php?rid=5338051&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00620.x Conclusion In our cerebral venous thrombosis cohort, inflammatory bowel disease is present in 2·3% of cases. As cerebral venous thrombosis has no specific feature and may reveal inflammatory bowel disease, intestinal signs should be systematically looked for. All physicians caring for inflammatory bowel disease patients must consider cerebral venous thrombosis in cases of unusual headache or focal neurological symptoms. Treatment is based on full anticoagulation and specific inflammatory bowel disease treatment. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5338051 Fri, 21 Oct 2011 04:00:00 +0100 5338051 Are stroke units cost effective? Evidence from a New Zealand stroke incidence and population‐based study http://www.medworm.com/index.php?rid=5338054&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00632.x Conclusion Stroke unit care was cost effective in Auckland, New Zealand. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5338054 Thu, 20 Oct 2011 04:00:00 +0100 5338054 Preceding intravenous thrombolysis facilitates endovascular mechanical recanalization in large intracranial artery occlusion http://www.medworm.com/index.php?rid=5338053&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00639.x Conclusions Our findings suggest that preceding intravenous thrombolysis may reduce the intervention time in patients treated by endovascular mechanical recanalization. However, due to the retrospective design of our study, these findings have to be interpreted with caution and need confirmation in a larger patient population. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5338053 Thu, 20 Oct 2011 04:00:00 +0100 5338053 Association of two single nucleotide polymorphisms from genomewide association studies with clinical phenotypes of cerebral ischemia http://www.medworm.com/index.php?rid=5338052&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00658.x Conclusions This is the first study to show an association of rs11833579 with multiple episodes of cerebral ischemia of atherothrombotic origin, and of rs11833579 and rs12425791 with short duration of ischemia. Also, we found an association of both single nucleotide polymorphisms with atherosclerotic lesions in the extracranial vessels on CT‐angiography. Together this suggests a relationship between the two single nucleotide polymorphisms and large artery pathology. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5338052 Thu, 20 Oct 2011 04:00:00 +0100 5338052 Three dimensional model‐based analysis of the lenticulostriate arteries and identification of the vessels correlated to the infarct area: preliminary results http://www.medworm.com/index.php?rid=5298182&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00611.x Conclusions These preliminary results demonstrated that 7 T magnetic resonance imaging together with a three dimensional image analysis and modeling technique could provide information for detection of the vessel related to the infarct. In addition, three dimensional image analysis and modeling of vessels could further provide quantitative information on the microvessel structures comprising diameter, length and tortuosity. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5298182 Thu, 06 Oct 2011 04:00:00 +0100 5298182 Trade‐offs between effectiveness and efficiency in stroke rehabilitation http://www.medworm.com/index.php?rid=5298181&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00612.x Conclusions There are trade‐offs between effectiveness and efficiency during inpatient sub‐acute stroke rehabilitation with respect to admission functional status and length of stay. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5298181 Thu, 06 Oct 2011 04:00:00 +0100 5298181 Disparities between prescribing of secondary prevention therapies for stroke and coronary artery disease in general practice http://www.medworm.com/index.php?rid=5298180&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00613.x Conclusions This study reaffirms the large treatment gap in the uptake of secondary prevention for cardiovascular disease in primary care settings, being much greater for patients with cerebral compared with cardiac cardiovascular disease. This appears to be related to differential perceptions of cardiovascular risk across different vascular territories in both patients and doctors. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5298180 Thu, 06 Oct 2011 04:00:00 +0100 5298180 The transforming growth factor‐β receptor genes and the risk of intracranial aneurysms http://www.medworm.com/index.php?rid=5298179&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00615.x Conclusions We found no evidence for TGFBR1 and TGFBR2 as susceptibility genes for intracranial aneurysm in the Dutch population. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5298179 Thu, 06 Oct 2011 04:00:00 +0100 5298179 Very early poststroke aphasia therapy: a pilot randomized controlled efficacy trial http://www.medworm.com/index.php?rid=5298178&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00631.x Conclusions Daily aphasia therapy in very early stroke recovery improved communication outcomes in people with moderate to severe aphasia. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5298178 Thu, 06 Oct 2011 04:00:00 +0100 5298178 Stepping towards prevention of bone loss after stroke: a systematic review of the skeletal effects of physical activity after stroke http://www.medworm.com/index.php?rid=5287336&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00645.x Abstract Bone loss after stroke is pronounced, and contributes to increased fracture risk. People who fracture after stroke experience reduced mobility and increased mortality. Physical activity can maintain or improve bone mineral density and structure in healthy older adults, likely reducing fracture risk. The purpose of this systematic review was to investigate the skeletal effects of physical activity in adults affected by stroke. A search of electronic databases was undertaken.
Selection criteria of trials were
• prospective and controlled
• physical activity‐based intervention
• participants with history of stroke, and
• bone‐related outcome measures.
Effect sizes were calculated for outcomes of paretic and nonparetic limbs. Three of 349 identified records met... International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5287336 Tue, 04 Oct 2011 04:00:00 +0100 5287336 Neurorehabilitation in Sri Lanka: an emerging sub‐specialty for neurology trainees http://www.medworm.com/index.php?rid=5287335&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00625.x Sri Lanka has an ageing population with an impending epidemic of stroke at hand. Stroke is the leading cause of adult disability in Sri Lanka. Sri Lanka has seen many recent advances in stroke services in the recent past providing a benchmark example for the countries in the Asia Pacific region, modeling the best care for stroke patients across the region with limited facilities they have. Three postgraduate trainees in neurology and medicine from Sri Lanka will spend a year at Western Health/ University of Melbourne, Melbourne, Australia for a period of 12 months for training in neurorehabilitation for stroke. It is timely for neurology trainees and trainees in internal medicine in Sri Lanka to be interested in neurorehabilitation. We sincerely hope the Board of study of Neurology, Post G... International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5287335 Tue, 04 Oct 2011 04:00:00 +0100 5287335 The Second Stroke Audit of Catalonia shows improvements in many, but not all quality indicators http://www.medworm.com/index.php?rid=5287334&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00638.x Conclusions The Second Stroke Audit showed improvements in most dimensions of care, although unexpectedly a few but relevant performance measures became worse. Therefore, periodic stroke audits are needed to check changes in quality of care over time. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5287334 Tue, 04 Oct 2011 04:00:00 +0100 5287334 Stroke patients do not need to be inactive in the first two‐weeks after stroke: results from a stroke unit focused on early rehabilitation http://www.medworm.com/index.php?rid=5432824&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00697.x ConclusionThis study shows that it is possible for acute stroke patients to spend most of the active day out of bed and to engage in higher motor activities up to 20% of the time. It also shows that it is feasible for severely affected stroke patients to stay out of bed in the early phase after stroke. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5432824 Sat, 01 Oct 2011 04:00:00 +0100 5432824 Thrombolytic therapy for acute ischemic stroke after recent transient ischemic attack http://www.medworm.com/index.php?rid=5389794&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00690.x ConclusionsTransient ischemic attack preceding ischemic stroke does not appear to have a major influence on outcomes following thrombolysis. Patients with prior ipsilateral transient ischemic attack appear not to be at higher risk of bleeding complications. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5389794 Sat, 01 Oct 2011 04:00:00 +0100 5389794 A randomized placebo controlled trial of early treatment of acute ischemic stroke with atorvastatin and irbesartan http://www.medworm.com/index.php?rid=5365279&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00653.x Conclusions Treatment with atorvastatin and irbesartan, initiated on day 3 after acute ischemic stroke, did not appear to substantially modify infarct growth. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5365279 Sat, 01 Oct 2011 04:00:00 +0100 5365279 Benefits of intravenous thrombolysis in acute ischemic stroke related to extra cranial internal carotid dissection. Dream or reality? http://www.medworm.com/index.php?rid=5338050&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00637.x Conclusions As compared with other etiologies, stroke due to extracranial internal carotid dissection seems to obtain similar benefits from intravenous thrombolysis in outcome at three‐months. Although intravenous thrombolysis is safe in stroke attributable to extracranial internal carotid dissection, no differences in outcome were found when comparing intravenous thrombolysis treated with nonintravenous thrombolysis‐treated patients, even after adjustment for stroke severity. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5338050 Sat, 01 Oct 2011 04:00:00 +0100 5338050 Bed rest or mobilization after rt‐PA? A case‐crossover study of factors influencing clinical decision making in stroke services http://www.medworm.com/index.php?rid=5316802&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00660.x ConclusionGrowing interest in development of clear protocols that guide first mobilization after recombinant tissue plasminogen activator prompted this study. We have identified factors that may influence decisions about when to allow patients to mobilize after recombinant tissue plasminogen activator. These, combined with emerging evidence of risks and benefits of early mobilization, should help protocol development in the future. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5316802 Sat, 01 Oct 2011 04:00:00 +0100 5316802 Association of the phosphodiesterase 4D (PDE4D) gene and cardioembolic stroke in an Australian cohort http://www.medworm.com/index.php?rid=5305850&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00616.x Conclusions Our findings demonstrated an association between cardioembolic stroke and phosphodiesterase 4D single nucleotide polymorphisms rs152312 and 45. No significant association was found for the other four single nucleotide polymorphisms investigated within the phosphodiesterase 4D gene. We propose that the results from this Australian population support the concept that a large prospective international study is required to investigate the role of phosphodiesterase 4D in the cardiogenic cause of ischemic stroke. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5305850 Sat, 01 Oct 2011 04:00:00 +0100 5305850 Long‐term risk of recurrent stroke in young cryptogenic stroke patients with and without patent foramen ovale http://www.medworm.com/index.php?rid=5298177&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00641.x Conclusions Young patients with cryptogenic ischemic stroke with and without patent foramen ovale have a low recurrence rate in a long‐term follow‐up and most present a favorable outcome. Patent foramen ovale with or without atrial septal aneurysm did not increase the risk of recurrence. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5298177 Sat, 01 Oct 2011 04:00:00 +0100 5298177 Ischemic involvement of the primary motor cortex is a prognostic factor in acute stroke http://www.medworm.com/index.php?rid=5287333&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00640.x Conclusions 3T diffusion‐weighted imaging can identify ischemic involvement on the primary motor cortex and may provide useful information for predicting outcome during the hyperacute stage. Ischemic involvement on the primary motor cortex has a significant negative impact on recovery. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5287333 Sat, 01 Oct 2011 04:00:00 +0100 5287333 Conference diary http://www.medworm.com/index.php?rid=5252047&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00665.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5252047 Mon, 26 Sep 2011 00:59:11 +0100 5252047 An epidemiological study of stroke and its sub‐types in the over 55 Mongolian and Han populations in a pastoral area of inner Mongolia http://www.medworm.com/index.php?rid=5252046&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00649.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5252046 Mon, 26 Sep 2011 00:59:09 +0100 5252046 CXCR4/SDF‐1α‐chemokine regulates neurogenesis and/or angiogenesis within the vascular niche of ischemic rats; however, does SDF‐1α play a role in repair? http://www.medworm.com/index.php?rid=5252045&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00651.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5252045 Mon, 26 Sep 2011 00:59:07 +0100 5252045 Stratification with CHA2DS2‐VASc score is better than CHADS2 score in reducing ischemic stroke risk in patients with atrial fibrillation http://www.medworm.com/index.php?rid=5252044&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00650.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5252044 Mon, 26 Sep 2011 00:59:06 +0100 5252044 Standard medical management in secondary prevention of ischemic stroke in China (SMART) http://www.medworm.com/index.php?rid=5252043&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00648.x This study will investigate the current status of secondary ischemic stroke prevention in China, and implement a standard medical program in ischemic stroke and/or transient ischemic attack patients, and to examine the feasibility and efficacy of the program.Design This is a multicentre, parallel, randomized, open label, controlled trial to evaluate the feasibility and efficacy of a recommended guideline based program (SMART) in secondary stroke prevention. Forty‐eight sites across Mainland China will participate in the trial. The number of enrolled patients in the study will be 4074. Primary outcome includes the proportion of patients adherent to eligible measures recommend by the SMART program, which is derived from current prevention guidelines for ischemic stroke, and the propo... International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5252043 Mon, 26 Sep 2011 00:59:04 +0100 5252043 Preventing recurrence of thromboembolic events through coordinated treatment in the District of Columbia http://www.medworm.com/index.php?rid=5252042&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00654.x Conclusion PROTECT DC will determine whether a Phase III trial of stroke navigation for urban underserved individuals to improve adherence to secondary stroke prevention behaviors is warranted. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5252042 Mon, 26 Sep 2011 00:59:02 +0100 5252042 Toward understanding the atrial septum in cryptogenic stroke http://www.medworm.com/index.php?rid=5252041&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00647.x Ischemic stroke in younger people is common, and often remains unexplained. There is a well‐documented association between unexplained stroke in younger people, and the presence of a patent foramen ovale. Therefore, in the absence of a clear cause of stroke, the heart is often assessed in detail for such lower risk causes of stroke. This usually involves imaging with a transesophageal echo, and investigation for a right‐to‐left shunt. An understanding of the anatomy of the atrial septum, and its associated abnormalities, is important for the stroke neurologist charged with decision making regarding appropriate secondary prevention. In this paper, we review the development and anatomy of the right heart with a focus on patent foramen ovale, and other associated abnormalities. We discu... International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5252041 Mon, 26 Sep 2011 00:59:00 +0100 5252041 Is the spontaneously hypertensive stroke prone rat a pertinent model of sub cortical ischemic stroke? A systematic review http://www.medworm.com/index.php?rid=5252040&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00659.x The spontaneously hypertensive stroke prone rat is best known as an inducible model of large artery stroke. Spontaneous strokes and stroke propensity in the spontaneously hypertensive stroke prone rat are less well characterized; however, could be relevant to human lacunar stroke. We systematically reviewed the literature to assess the brain tissue and small vessel pathology underlying the spontaneous strokes of the spontaneously hypertensive stroke prone rat. We searched systematically three online databases from 1970 to May 2010; excluded duplicates, reviews, and articles describing the consequences of induced middle cerebral artery occlusion or noncerebral pathology; and recorded data describing brain region and the vessels examined, number of animals, age, dietary salt intake, vascular... International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5252040 Mon, 26 Sep 2011 00:58:59 +0100 5252040 Constraint‐induced movement therapy for the upper paretic limb in acute or sub‐acute stroke: a systematic review http://www.medworm.com/index.php?rid=5252039&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00646.x Abstract Constraint‐induced movement therapy is a commonly used intervention to improve upper limb function after stroke. However, the effectiveness of constraint‐induced movement therapy and its optimal dosage during acute or sub‐acute stroke is still under debate. To examine the literature on the effects of constraint‐induced movement therapy in acute or sub‐acute stroke. A literature search was performed to identify randomized, controlled trials; studies with the same outcome measure were pooled by calculating the mean difference. Separate quantitative analyses for high‐intensity and low‐intensity constraint‐induced movement therapy were applied when possible. Five randomized, controlled trials were included, comprising 106 participants. The meta‐analysis demonst... International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5252039 Mon, 26 Sep 2011 00:58:57 +0100 5252039 Can stroke cause neurodegenerative dementia? http://www.medworm.com/index.php?rid=5252038&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00666.x Stroke and dementia have typically been housed in different taxonomies. They are considered to be exemplars of very different forms of brain injury: stroke as an acute vascular injury and dementia as a progressive degenerative disease. Yet there is definite overlap between the two conditions: stroke increases the likelihood of developing dementia. Recent work has confirmed that vascular risk factors such as diabetes and hypertension predispose to dementia. However, in the absence of any clear findings of a direct pathway from stroke to degenerative dementia, the separation has persisted. In this review, we summarize the evidence relating to whether stroke can initiate or promote degenerative dementia and, in particular, Alzheimer's disease. The evidence comes from autopsy studies, from bra... International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5252038 Mon, 26 Sep 2011 00:58:55 +0100 5252038 Is a prestroke modified Rankin Scale sensible? http://www.medworm.com/index.php?rid=5252037&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00661.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5252037 Mon, 26 Sep 2011 00:58:54 +0100 5252037 The future of basic science research and stroke: hubris and translational stroke research http://www.medworm.com/index.php?rid=5252036&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00657.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5252036 Mon, 26 Sep 2011 00:58:52 +0100 5252036 The International Journal of Stroke welcomes Professor Patrick Lyden as Associate Editor http://www.medworm.com/index.php?rid=5252035&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00664.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5252035 Mon, 26 Sep 2011 00:58:42 +0100 5252035 World Stroke Day Editorial http://www.medworm.com/index.php?rid=5252034&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00656.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5252034 Mon, 26 Sep 2011 00:58:40 +0100 5252034 World Stroke Day http://www.medworm.com/index.php?rid=5252033&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00655.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5252033 Mon, 26 Sep 2011 00:58:38 +0100 5252033 IJS announces journal series on stroke, cognition and vascular dementia http://www.medworm.com/index.php?rid=5252032&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00662.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5252032 Mon, 26 Sep 2011 00:58:37 +0100 5252032 World Stroke Day special edition: where are we six‐years on? http://www.medworm.com/index.php?rid=5252031&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00663.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5252031 Mon, 26 Sep 2011 00:58:35 +0100 5252031 Author Index http://www.medworm.com/index.php?rid=5121097&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00644.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5121097 Fri, 12 Aug 2011 21:05:06 +0100 5121097 Posters (p35‐52 only) http://www.medworm.com/index.php?rid=5121096&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4930.2011.00643.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5121096 Fri, 12 Aug 2011 21:05:05 +0100 5121096 Oral Abstracts http://www.medworm.com/index.php?rid=5121095&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4930.2011.00642.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5121095 Fri, 12 Aug 2011 21:05:04 +0100 5121095 Conference diary http://www.medworm.com/index.php?rid=5022502&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00636.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5022502 Wed, 13 Jul 2011 20:15:00 +0100 5022502 Impact of stroke unit care: an Indian perspective http://www.medworm.com/index.php?rid=5022501&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00626.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5022501 Wed, 13 Jul 2011 20:14:49 +0100 5022501 Female gender is a factor of worse outcome in acute stroke even after thrombolytic treatment http://www.medworm.com/index.php?rid=5022500&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00627.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5022500 Wed, 13 Jul 2011 20:14:40 +0100 5022500 Author Response to Social Marketing and the FAST Campaign http://www.medworm.com/index.php?rid=5022499&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00630_1.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5022499 Wed, 13 Jul 2011 20:14:37 +0100 5022499 Social Marketing and the FAST Campaign http://www.medworm.com/index.php?rid=5022498&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00630.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5022498 Wed, 13 Jul 2011 20:14:35 +0100 5022498 Carotid atherosclerotic disease and cognitive function: mechanisms identifying new therapeutic targets http://www.medworm.com/index.php?rid=5022497&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00628.x The treatment of carotid atherosclerotic disease lies primarily in decreasing the risk of stroke. Many investigations have suggested carotid atherosclerotic disease as being independently associated with cognitive dysfunction, also supporting the notion that in sub‐clinical stages, carotid atherosclerotic disease may not be truly silent. An improvement in cognitive function following revascularization approaches may be expected from the reduced embolism and the improved hemodynamics achieved. However, there are no strong data indicating a cognitive change after carotid angioplasty and stenting or carotid endarterectomy in patients who do not experience stroke complications and there is no evidence to support the performance of prophylactic revascularization procedures with the aim of pre... International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5022497 Wed, 13 Jul 2011 20:14:33 +0100 5022497 The South African guideline for the management of ischemic stroke and transient ischemic attack: recommendations for a resource‐constrained health care setting http://www.medworm.com/index.php?rid=5022496&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00629.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5022496 Wed, 13 Jul 2011 20:14:27 +0100 5022496 Risk factor profiles of South Asians with cerebrovascular disease http://www.medworm.com/index.php?rid=5022495&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00622.x Conclusion South Asians in an urban slum often have multiple modifiable risk factors for cerebrovascular event, increasing numbers of risk factors increase the risk of stroke and TIA. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5022495 Wed, 13 Jul 2011 20:14:26 +0100 5022495 Current role of biomarkers in carotid disease: a systematic review http://www.medworm.com/index.php?rid=5022494&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00623.x Conclusion At present, heterogeneous data support evidence that biological markers can help existing practices to more accurately assess patients at risk for stroke. Randomized‐controlled trials for carotid artery disease and carotid intervention, incorporating biomarkers, are needed. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5022494 Wed, 13 Jul 2011 20:14:24 +0100 5022494 Poststroke fatigue: an emerging, critical issue in stroke medicine http://www.medworm.com/index.php?rid=5022493&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00624.x Poststroke fatigue is a common and disabling condition. However, few studies on or therapeutic trials addressing poststroke fatigue have appeared in the literature. We aimed to review the prevalence, natural course, potential predisposing factors (physiological, psychocognitive, and organic), and pharmacological and nonpharmacological treatments of poststroke fatigue. Using PubMed CINAHL and PsycINFO, we reviewed all the available literature on poststroke fatigue and related issues. The prevalence of poststroke fatigue ranges from 23% to 75%, depending on the definition of fatigue and the characteristics of the patients included. Poststroke fatigue seems to be of complex etiology. Predisposing factors were physiological ones including functional disability, prestroke fatigue, medical comor... International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5022493 Wed, 13 Jul 2011 20:14:23 +0100 5022493 Predictors of poststroke mobility: systematic review http://www.medworm.com/index.php?rid=5022492&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00621.x Regaining poststroke mobility is considered a primary goal of the stroke patient in early rehabilitation. Predictive recovery of poststroke mobility is clinically important, and provides important information to healthcare professionals, patients and their families. We conducted a systematic review aimed at identifying the predictive or associated baseline factors, assessed within one‐week of stroke onset, and the recovery of poststroke mobility within 30 days. A comprehensive search strategy was applied to all major electronic databases to identify potentially relevant studies. Included in the review are two studies that evaluate the predictive value of baseline factors by developing a prognostic model, and three studies that assess the baseline factors that were associated with the out... International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5022492 Wed, 13 Jul 2011 20:14:22 +0100 5022492 Oral glucose tolerance test should be performed after stroke and transient ischemic attack http://www.medworm.com/index.php?rid=5022491&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00619.x Diabetes mellitus predicts an increased risk of stroke, and acute hyperglycemia during acute stroke predicts the presence of undiagnosed diabetes mellitus. Based on recent investigations, 28% of previously nondiabetic stroke or transient ischemic attack patients have undetected diabetes mellitus, and 29% have impaired glucose tolerance, while only 43% have normal glycemic control. Oral glucose tolerance test is a far more sensitive and reliable test of diabetes mellitus than fasting blood glucose or HbA1c, and is recommended in the World Health Organization criteria for diagnosing diabetes mellitus and impaired glucose tolerance. Secondary prevention of stroke is different in patients with diabetes mellitus and the detection of impaired glucose tolerance would ring alarm bells of impending... International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5022491 Wed, 13 Jul 2011 20:14:19 +0100 5022491 Listening to fluoxetine: a hot message from the FLAME trial of poststroke motor recovery http://www.medworm.com/index.php?rid=5022490&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00618.x The fluoxetine for motor recovery after acute ischemic stroke study was a double blind, placebo‐controlled trial examining the effects of fluoxetine in patients five‐ to 10 days after an ischemic stroke. The study found motor improvement to 90 days poststroke, measured as the change in the Fugl–Meyer score, was significantly greater in the fluoxetine group as compared with the placebo group, and that this finding was significant after adjusting for depression. Patients randomized to fluoxetine also had less disability (modified Rankin Scale 0–2). The study adds to the weight of data suggesting that viable strategies exist to improve patient outcomes by initiating a restorative agent, days after stroke injury is fixed. Stroke remains among the leading causes of human disability. Cur... International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5022490 Wed, 13 Jul 2011 20:14:18 +0100 5022490 Have medical therapy and stenting been fairly compared? A repercussion upon termination of recruitment in the SAMMPRIS trial http://www.medworm.com/index.php?rid=5022489&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00634.x The recruitment of the Stenting and Aggressive Medical Management for Preventing Recurrent stroke in Intracranial Stenosis, an National Institute of Neurological Disorders and Stroke‐funded clinic trial evaluating aggressive medical therapy vs. adjunctive intracranial angioplasty and stenting in high‐grade symptomatic intracranial stenosis, was prematurely terminated by the study Data Safety Monitoring Board. The significantly higher 30‐day stroke and death rate in the stenting arm led to a conclusion from the National Institute of Neurological Disorders and Stroke and the Executive Committee that aggressive medical management alone was superior to angioplasty combined with stenting. The authors discussed on the potential pitfalls, which may render this conclusion premature and expla... International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5022489 Wed, 13 Jul 2011 20:14:16 +0100 5022489 As one door closes, another opens http://www.medworm.com/index.php?rid=5022488&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00635.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=5022488 Wed, 13 Jul 2011 20:14:06 +0100 5022488 N‐terminal probrain natriuretic peptide as a biomarker of cardioembolic stroke http://www.medworm.com/index.php?rid=4905772&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00606.x Conclusion N‐terminal probrain natriuretic peptide is a biomarker with a good accuracy to predict ischemic stroke of cardioembolic cause, namely associated with atrial fibrillation. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=4905772 Sun, 05 Jun 2011 23:00:00 +0100 4905772 Outcomes in acute ischemic strokes presenting with disabling neurologic deficits without intracranial vascular occlusion http://www.medworm.com/index.php?rid=4905771&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00607.x Conclusion Stroke without intracranial occlusions are not a benign entity. Factors that are independently associated with decreased likelihood of a good outcome are higher baseline NIHSS, and older age. Treatment with tissue plasminogen activator is not a predictor of outcome. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=4905771 Sun, 05 Jun 2011 23:00:00 +0100 4905771 The Membrane‐Activated Chelator Stroke Intervention (MACSI) Trial of DP‐b99 in acute ischemic stroke: a randomized, double‐blind, placebo‐controlled, multinational pivotal Phase III study http://www.medworm.com/index.php?rid=4905770&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00608.x Conclusion This Phase III Membrane‐Activated Chelator Stroke Intervention trial is based on promising data derived from previous Phase I and II DP‐b99 trials and capitalizes on lessons learned from failures of past stroke studies in relation to neuroprotection, patient selection and data analysis. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=4905770 Sun, 05 Jun 2011 23:00:00 +0100 4905770 Red cell distribution width does not predict stroke severity or functional outcome http://www.medworm.com/index.php?rid=4905769&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00609.x Conclusions Red cell distribution width, assessed during the early phase of acute ischemic stroke, does not predict severity or functional outcome. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=4905769 Sun, 05 Jun 2011 23:00:00 +0100 4905769 Late Night Activity Regarding Stroke Codes: LuNAR strokes http://www.medworm.com/index.php?rid=4987464&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00610.x Conclusions Our stroke center experience showed no difference in diagnosis of acute ischemic stroke between day and night stroke codes. This similarity was further supported in similar rates of tissue plasminogen activator administration. Late night strokes may warrant a more rapid stroke specialist evaluation due to the longer time elapsed from symptom onset and the longer time to computed tomography scan. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=4987464 Tue, 31 May 2011 23:00:00 +0100 4987464 Calculation of numbers‐needed‐to‐treat in parallel group trials assessing ordinal outcomes: case examples from acute stroke and stroke prevention http://www.medworm.com/index.php?rid=4905768&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00614.x Conclusions Number‐needed‐to‐treat may be calculated for ordinal outcome data derived from parallel group stroke trials; such numbers‐needed‐to‐treat are lower than those calculated for binary outcomes. Their use complements the use of ordinal statistical approaches in the analysis of ordered categorical data. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=4905768 Tue, 31 May 2011 23:00:00 +0100 4905768 Conference diary http://www.medworm.com/index.php?rid=4807588&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00598.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=4807588 Wed, 11 May 2011 19:10:58 +0100 4807588 Role of vasodilation in cognitive impairment http://www.medworm.com/index.php?rid=4807587&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00601.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=4807587 Wed, 11 May 2011 19:10:57 +0100 4807587 A new ultrasound method for evaluating dysphagia in acute stroke patients http://www.medworm.com/index.php?rid=4807586&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00603.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=4807586 Wed, 11 May 2011 19:10:56 +0100 4807586 Reply http://www.medworm.com/index.php?rid=4807585&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00586_1.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=4807585 Wed, 11 May 2011 19:10:55 +0100 4807585 Hyperglycemia in thrombolysed acute ischemic stroke patients http://www.medworm.com/index.php?rid=4807584&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00586.x (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=4807584 Wed, 11 May 2011 19:10:54 +0100 4807584 Singapore ministry of health clinical practice guidelines on stroke and transient ischemic attacks http://www.medworm.com/index.php?rid=4807583&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00602.x The primary aim of these guidelines is to assist individual clinicians, hospital departments, and hospital administrators to produce local protocols for the:•assessment, investigation and immediate management of individuals with a transient ischemic attack or acute stroke (other than sub‐arachnoid hemorrhage), and•secondary prevention and risk factor management following a transient ischemic attack or acute stroke.The secondary aim of these guidelines is to suggest methods for implementation and clinical audit. The workgroup preparing these guidelines was formed by the Ministry of Health, Singapore. It comprised healthcare workers from relevant specialties, family medicine, nursing, occupational therapy, and a lay patient advocate. The Scottish Intercollegiate Guidelines Network's Cl... International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=4807583 Wed, 11 May 2011 19:10:51 +0100 4807583 Stroke in Myanmar: attitudes and treatment http://www.medworm.com/index.php?rid=4807582&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00599.x The burden of stroke in low‐middle‐income countries has increased during the past few decades but has decreased in developed countries and it is important to know why; though it may be attributed primarily to attitudes toward stroke management and prevention among doctors, and consequently in the population. We have conducted a study to investigate how stroke is managed in Myanmar, south‐east Asia, with a population of approximately 60 million. We found that attitude differed markedly from that reflected in international guidelines. We expected this attitude to be reflected in the general population and speculate that the poor development and sub‐optimal work on prevention and treatment of stroke stems from these attitudes. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=4807582 Wed, 11 May 2011 19:10:49 +0100 4807582 Epidemiology of stroke in Italy http://www.medworm.com/index.php?rid=4807581&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00594.x This study reviews available data on stroke epidemiology in Italy. Data were identified through Medline/PubMed, Embase, and from reference lists, related articles, and citation lists of each of the retrieved papers. Nineteen papers were considered, referring to selected stroke‐registers performed in seven different geographical areas: Acquaviva‐Casamassima county, Aeolian Islands, Aosta district, Belluno district, L'Aquila district, Trasimeno area, and Vibo Valentia district. Registers covered a total population of 2 262 940 people, with a hospitalization rate from 82% to 98%. The mean age at stroke onset was 74·6 ± 1·1 years, 72·3 years in men and 76·6 years in women. Among all strokes:•67·3–82·6% were classified ischemic•9·9–19·6% as primary intracerebral hemorrh... International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=4807581 Wed, 11 May 2011 19:10:46 +0100 4807581 Treatment issues in spontaneous cervicocephalic artery dissections http://www.medworm.com/index.php?rid=4807580&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00605.x The management of cervicocephalic arterial dissections raises many unsolved issues such as: how to best acutely treat patients who present with ischemic stroke or occasionally with sub‐arachnoid hemorrhage? How to best prevent ischemic stroke in patients who present with purely local signs such as headache, painful Horner Syndrome or neck pain? How long and how should patients be treated after cervicocephalic arterial dissections? Can patients resume their sports activities and when? The consensus is that, given the well‐established initial thromboembolic risk, an urgent antithrombotic treatment is required in patients with a recent nonhemorrhagic cervicocephalic arterial dissection, but the type of antithrombotic treatment – anticoagulants or aspirin – as well as the indication fo... International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=4807580 Wed, 11 May 2011 19:10:45 +0100 4807580 Early Neurological Deterioration (END) after stroke: the END depends on the definition http://www.medworm.com/index.php?rid=4807579&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00596.x Neurological worsening poststroke is a serious clinical condition that occurs in up to one‐third of patients. This brief report summarizes several of the current issues faced by neurologists in recognizing and managing patients who experience a worsening neurological status following hospital admission. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=4807579 Wed, 11 May 2011 19:10:44 +0100 4807579 Cilostazol: a drug particularly effective for Asians? http://www.medworm.com/index.php?rid=4807578&cid=s_32221_25_f&fid=32221&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1747-4949.2011.00597.x Cilostazol is an antiplatelet drug often used in Asia; however, it is rarely used in the western hemisphere, particularly for stroke patients. Further studies of cilostazol in other ethnicities are required to prove or disprove whether this drug is also beneficial in non‐Asian populations. (Source: International Journal of Stroke) International Journal of Stroke journals http://www.medworm.com/rss/comments.php?id=4807578 Wed, 11 May 2011 19:10:43 +0100 4807578