MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'International Journal of Surgical Pathology' source. Sat, 14 Jan 2012 12:12:24 +0100 http://www.medworm.com/index.php?rid=5411478&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F5%2F692%3Frss%3D1 This study reports a case of paratesticular serous papillary adenocarcinoma (SPA) in an 87-year-old man that was misdiagnosed as malignant mesothelioma (MM) and is 37 years older than previous cases, highlighting that SPA does not occur exclusively in young patients as described. Immunohistochemistry revealed expression of pankeratin, CAM 5.2, CK7, CK903, Ber-EP4, vimentin, S100, and CEA and virtually no expression of CK5/6, CK20, calretinin, thrombomodulin, or glypican 3. Expression of adjacent nonneoplastic tunica vaginalis mesothelium was assessed in this patient and additional specimens. Profiles of paratesticular SPA and MM were summarized and compared with paratesticular mesothelium. Nontumoral stromal and entrapped mesothelial expression were 2 diagnostic pitfalls in this case that ... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5411478 Tue, 15 Nov 2011 05:00:00 +0100 5411478 http://www.medworm.com/index.php?rid=5411477&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F5%2F685%3Frss%3D1 The authors describe the case of a 65-year-old woman who was HIV negative and had a lymph node biopsy that showed concurrent follicular lymphoma (FL; grade 3A), Kaposi sarcoma (KS), and Castleman’s disease (CD) with coinfection by human herpes virus-8 (HHV-8) and Epstein-Barr virus (EBV). The lymphoma was positive for CD20, CD10, and BCL6 and negative for BCL2. Flow cytometry showed a clonal lambda B-cell population, and polymerase chain reaction (PCR) showed a clonal immunoglobulin heavy chain gene rearrangement, confirming a neoplastic B-cell process. Focally, the FL component showed numerous EBER1-positive cells, with rare HHV-8-positive cells. The KS component showed strong HHV-8 expression with rare EBER1-positive cells. The CD component showed scattered HHV-8, viral interleukin... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5411477 Tue, 15 Nov 2011 05:00:00 +0100 5411477 http://www.medworm.com/index.php?rid=5411476&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Freprint%2F19%2F5%2F681%3Frss%3D1 (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5411476 Tue, 15 Nov 2011 05:00:00 +0100 5411476 http://www.medworm.com/index.php?rid=5411475&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F5%2F677%3Frss%3D1 Metaplastic thymoma is an extremely rare tumor. To date, only 17 cases of metaplastic thymoma have been reported. To the best of the authors’ knowledge, this is the second reported case of a sarcomatoid carcinoma arising in metaplastic thymoma; the carcinoma in this case is larger than that in the previous case. A 63-year-old woman with cough and asthenia for 2 weeks was admitted to the hospital. Computed tomography (CT) revealed a giant mass on the right side of the front mediastinum medium. The mediastinal tumor was excised, and additional pathological examinations, immunohistochemical tests, and electron-microscopic tests were performed. The tumor was diagnosed as a sarcomatoid carcinoma arising in metaplastic thymoma. Here, the authors discuss the clinical pathology of the sarcom... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5411475 Tue, 15 Nov 2011 05:00:00 +0100 5411475 http://www.medworm.com/index.php?rid=5411474&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F5%2F672%3Frss%3D1 Intravascular lymphoma (IVL) of the uterus, a rare manifestation of malignant lymphoma, was diagnosed in a 71-year-old woman, who had fever, edema, and genital bleeding. Only 4 cases of uterine IVL have been reported in detail in the literature in English, to the author’s knowledge. The patient was treated with total hysterectomy with bilateral salpingo-oophorectomy, accompanied by subsequent chemotherapy in combination with rituximab. Preoperative endometrial cytology and biopsy showed atypical lymphocytes intermingled with nonneoplastic epithelial cells. Intravascular proliferation of atypical lymphocytes was detected by histological examination of the resected materials, in which almost the entire uterine structure, including a large endometrial polyp, ovaries, and uterine tubes w... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5411474 Tue, 15 Nov 2011 05:00:00 +0100 5411474 http://www.medworm.com/index.php?rid=5411473&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F5%2F667%3Frss%3D1 Metanephric stromal tumor (MST) is a recently recognized benign renal stromal tumor. MST is thought to be part of a spectrum of benign metanephric renal lesions, which also includes the epithelial lesion metanephric adenoma and the mixed stromal–epithelial lesion metanephric adenofibroma. Metanephric lesions may represent hyperdifferentiated counterparts to Wilms’ tumor (WT). MST characteristically shows renovascular angiodysplasia and juxtaglomerular (JG) cell hyperplasia. This is remarkably similar to the renal pathology described in neurofibromatosis-1 (NF-1) syndrome, a condition which is also associated with WT. Here, we report the first case of MST arising in a patient with NF-1. The patient presented with hypertension, and the MST was associated with florid angiodysplasi... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5411473 Tue, 15 Nov 2011 05:00:00 +0100 5411473 http://www.medworm.com/index.php?rid=5411472&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F5%2F662%3Frss%3D1 This report discusses possible mechanisms by which extramedullary hematopoiesis may occur in vascular neoplasms. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5411472 Tue, 15 Nov 2011 05:00:00 +0100 5411472 http://www.medworm.com/index.php?rid=5411471&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F5%2F658%3Frss%3D1 Conclusion. An unusual case of a YST in the urachus is presented. This is the first reported adult case based on the authors’ bibliographic search. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5411471 Tue, 15 Nov 2011 05:00:00 +0100 5411471 http://www.medworm.com/index.php?rid=5411470&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F5%2F653%3Frss%3D1 Rhabdoid features in gastrointestinal stromal tumors (GISTs) are rare. To the authors’ knowledge, only 51 cases have been reported. Most of these reports consist of case series in which the rhabdoid GISTs comprise a small proportion of the tumors studied. Information regarding site of origin and clinical behavior is sparse. Although the stomach is the only site of origin documented, most reports do not include this data. Malignancy has not been reported, though follow-up is inadequate in most cases to comment on tumor behavior. Exon 11 mutations comprise all previously described KIT mutations, the majority of which are deletions. The authors present the case of a malignant small-intestinal rhabdoid GIST that recurred twice following resection and treatment with tyrosine kinase inhibi... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5411470 Tue, 15 Nov 2011 05:00:00 +0100 5411470 http://www.medworm.com/index.php?rid=5411469&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F5%2F649%3Frss%3D1 We report herein a case of endometrial dedifferentiated endometrioid carcinoma in a 45-year old lady with ovarian metastasis from the undifferentiated component. The primary endometrial tumor showed an undifferentiated component in an otherwise low grade endometrioid carcinoma. The undifferentiated component of these tumors can be misdiagnosed as the solid component of FIGO grade 3 in a pure endometrioid carcinoma. The recognition of an undifferentiated component in an otherwise low grade endometrioid carcinoma is very important, since dedifferentiated endometrioid adenocarcinoma has a worse prognosis when compared with FIGO grade 3 endometrioid carcinoma. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5411469 Tue, 15 Nov 2011 05:00:00 +0100 5411469 http://www.medworm.com/index.php?rid=5411468&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F5%2F643%3Frss%3D1 This study describes 2 cases of composite mantle cell lymphoma (MCL) and diffuse large B-cell lymphoma (DLBCL), which has not previously been reported. Each case demonstrated distinct populations of CD20 positive small and large atypical B cells. In both cases, only the small lymphocytes were positive for CD5 and cyclin D1, and fluorescence in situ hybridization (FISH) showed a t(11;14) translocation in the small lymphocytes but not in the large cells. Molecular studies for B-cell clonality showed a possible clonal relationship between the 2 components in one case but not the other. This study describes in detail the morphology, immunophenotype, FISH, and molecular analysis of both components in each case. To the authors’ knowledge, this represents the first report of juxtaposition o... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5411468 Tue, 15 Nov 2011 05:00:00 +0100 5411468 http://www.medworm.com/index.php?rid=5411467&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F5%2F637%3Frss%3D1 Rosai–Dorfman disease is a rare, benign histiocytic proliferative disorder that commonly affects the lymph nodes. Although extranodal involvement has been reported in diverse sites, manifestation in the cardiovascular system is extremely uncommon. Specifically, the involvement of the heart by Rosai–Dorfman disease is an extraordinarily infrequent event. Here, the authors present a case of Rosai–Dorfman disease arising in the right atrium in a symptomatic 61-year-old man who initially presented with pleuritic chest pain and was found to have a large, lobulated, and circumscribed right atrial mass. The lesion exhibited an exuberant histiocytic and chronic fibroinflammatory process with focal emperipolesis within histiocytes. Immunohistochemical studies demonstrated strong S... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5411467 Tue, 15 Nov 2011 05:00:00 +0100 5411467 http://www.medworm.com/index.php?rid=5411466&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F5%2F632%3Frss%3D1 Gastrointesinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract and they show differentiation towards interstitial cells of Cajal (ICC). Herein, we describe a case of a 60-year-old man presenting with symptoms mimicking adenomatous hyperplasia of the prostate that was subjected to repeated transurethral prostatectomies. Histologic and immunohistochemical examination showed a neoplastic process with characteristics consistent with GIST. Imaging studies confirmed a rectal origin of the tumor. Review of the literature revealed 20 cases of GISTs occurring in the prostate gland, either diagnosed as either primary GISTs or, more commonly, as rectal neoplasms extending to this organ. We add our case in this short list, emphasizing on the importance o... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5411466 Tue, 15 Nov 2011 05:00:00 +0100 5411466 http://www.medworm.com/index.php?rid=5411465&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F5%2F627%3Frss%3D1 Solid cell nests (SCNs) of the thyroid are single or multiple foci of solid and/or cystic clusters of squamoid cells (main cells) with a minor proportion of C-cells, found in the normal thyroid. The SCNs have also been reported in the heart as an ultimobranchial heterotopia. Here, the authors describe a case of thyroid-type SCNs associated with struma ovarii. Main cells were positive for simple and stratified epithelial-type cytokeratins, carcinoembryonic antigen, carbohydrate antigen 19.9, p63, bcl-2, and galectin-3. The neuroendocrine cell population was positive for chromogranin A and synaptophysin but negative for calcitonin, suggesting a common ancestor cell capable of dual differentiation toward thyroid follicular cells and hindgut-type endocrine cells. The existence of thyroid-type ... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5411465 Tue, 15 Nov 2011 05:00:00 +0100 5411465 http://www.medworm.com/index.php?rid=5411464&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F5%2F620%3Frss%3D1 In the past, undifferentiated (anaplastic) carcinoma of the thyroid included a small-cell variant with either a diffuse or a compact morphology. After the mid-1980s, with the advance of immunohistochemistry, almost all those rare tumors with the former characteristic were reclassified as low-grade lymphomas and those with the latter characteristic as small-cell variants of medullary carcinoma and poorly differentiated ("insular") carcinoma. Since then, no primary thyroid small-cell carcinoma has been reported in the literature, with the exception of a case of a small-cell (neuroendocrine) carcinoma, an exceedingly rare neoplasm akin to medullary carcinoma, with expression of neuroendocrine markers but lacking calcitonin immunoreactivity. Here, the authors report a primary small-cell carcin... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5411464 Tue, 15 Nov 2011 05:00:00 +0100 5411464 http://www.medworm.com/index.php?rid=5411463&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Freprint%2F19%2F5%2F617%3Frss%3D1 (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5411463 Tue, 15 Nov 2011 05:00:00 +0100 5411463 http://www.medworm.com/index.php?rid=5411462&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Freprint%2F19%2F5%2F614%3Frss%3D1 (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5411462 Tue, 15 Nov 2011 05:00:00 +0100 5411462 http://www.medworm.com/index.php?rid=5411461&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F5%2F607%3Frss%3D1 Conclusion: IHC of Notch markers is feasible and correlates with known prognostic factors consistent with a biological role of Notch signaling in breast cancer progression. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5411461 Tue, 15 Nov 2011 05:00:00 +0100 5411461 http://www.medworm.com/index.php?rid=5411460&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F5%2F597%3Frss%3D1 This study presents clinicopathologic and outcome features of 17 patients with metastatic tumor to the penis. Primary sites and histological types were as follows: 6 urothelial carcinomas of urinary bladder, 4 prostatic carcinomas (2 adenocarcinomas and 2 adenosquamous carcinomas), 2 colorectal adenocarcinomas, 2 pulmonary carcinomas (1 squamous cell carcinoma and 1 small cell carcinoma), 1 squamous cell carcinoma of base of the tongue, 1 cutaneous malignant melanoma, and 1 acute myeloid leukemia. Literature review revealed similar distribution of organ sites in 437 cases. Most of our tumors were metachronous. Interval between primary and penile metastasis ranged from 3 to 60 months (mean 16 months). Most of the patients presented with a penile mass. Priapism was observed in 4 patients. Th... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5411460 Tue, 15 Nov 2011 05:00:00 +0100 5411460 http://www.medworm.com/index.php?rid=5411459&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F5%2F588%3Frss%3D1 Discussion: GPR30 is more sensitive, but less specific than mesothelin for pancreatic adenocarcinoma. Mesothelin is detected in most adenocarcinoma fine needle aspirates. ER is rarely detected in pancreatic lesions. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5411459 Tue, 15 Nov 2011 05:00:00 +0100 5411459 http://www.medworm.com/index.php?rid=5411458&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F5%2F583%3Frss%3D1 This study reviews the clinicopathologic characteristics among these benign lesions of the vocal fold. A total of 78 nonneoplastic lesions of the vocal fold were reviewed by 2 pathologists for the presence of epithelial hyperplasia, basement membrane thickening, edema, vascular proliferation, and extracellular "amyloid-like" fibrin. In 46 cases with prebiopsy stroboscopic images, 2 otolaryngologists classified each lesion as polyp, nodule, Reinke’s edema, cyst, or other. They agreed in 43% (n = 20, 13 polyps, 5 nodules, 1 Reinke’s edema, 1 other) and disagreed in 57% (n = 26). There was no histologic feature that reliably distinguished among the lesions. In addition, reactive stromal cell atypia was present in 14 cases. Cysts were distinctive, as all were epithelial lined. The ... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5411458 Tue, 15 Nov 2011 05:00:00 +0100 5411458 http://www.medworm.com/index.php?rid=5411457&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F5%2F576%3Frss%3D1 Mobile encapsulated adipose tissue can be found in both the subcutis and peritoneal cavity. The cutaneous lesions are more common and better described; they are usually designated as "mobile encapsulated lipoma" or "nodular-cystic fat necrosis." The clinical name of abacus tumor describes best the small marble-like nodules that often can be moved freely through the subcutaneous tissue planes. Histopathologically, the nodules are composed of a dense fibrous capsule surrounding fat that may show varying degrees of necrosis, calcification, and lipomembranous changes. The peritoneal nodules are thought to originate from detached epiploic appendices. They are described occasionally in humans but more commonly in cows. Because these bovine mobile peritoneal bodies are clinically and histopatholo... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5411457 Tue, 15 Nov 2011 05:00:00 +0100 5411457 http://www.medworm.com/index.php?rid=5411456&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F5%2F570%3Frss%3D1 This article describes a method to circumvent these problems through the creation of a virtual ultrathin slide. This can be achieved by automated capturing of hundreds of images at high magnification and stitching them together into a digital image with a resolution of 4 nm/pixel. The pathologist can then navigate the virtual slide at his/her workstation computer. The image shows good contrast and resolution for diagnostic purposes, and most important, the pathologist can precisely note where the specific ultrastructural features are located. The setup required to implement virtual electron microscopy includes a transmission electron microscope equipped with motorized stage and automated digital image capture function, 2 free software components, self-developed software, and a desktop-grad... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5411456 Tue, 15 Nov 2011 05:00:00 +0100 5411456 http://www.medworm.com/index.php?rid=5411455&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F5%2F563%3Frss%3D1 Conclusion. The authors’ attempt to compare CLL with SLL with regards to cytogenetic and IgVH mutational status shows no statistically significant difference. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5411455 Tue, 15 Nov 2011 05:00:00 +0100 5411455 http://www.medworm.com/index.php?rid=5411454&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Freprint%2F19%2F5%2F561%3Frss%3D1 (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5411454 Tue, 15 Nov 2011 05:00:00 +0100 5411454 http://www.medworm.com/index.php?rid=5176840&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F4%2F552%3Frss%3D1 Double synchronous primaries are known to occasionally occur in gynecologic cancers. Cases of triple or quadruple synchronous primaries, with only 4 case reports in the literature, are extremely rare. The authors report the case of a 49-year-old para 2-0-0-2 woman who presented for surgical management of metastatic ovarian adenocarcinoma diagnosed at an outside institution. On examination of the surgical specimen, 3 synchronous primary carcinomas with multiple histologic features were identified within the ovaries, uterus, and cervix. Although rare, the possibility of triple synchronous primary malignancies should be considered when evaluating gynecologic malignancies. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5176840 Mon, 29 Aug 2011 23:00:00 +0100 5176840 http://www.medworm.com/index.php?rid=5176839&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F4%2F548%3Frss%3D1 Müllerianosis of the urinary bladder is a rare condition that encompasses 3 histological entities (endometriosis, endocervicosis, and endosalpingiosis). The authors report 2 patients with bladder müllerianosis, one of whom had endometriosis and the other a history of past pelvic surgery, describe the histological and cystoscopic features, and review the literature on this condition. Mucosal hyperemia and submucosal nodules or cysts with associated fibrosis and distortion of the bladder wall may mimic malignancy on cystoscopy, as may the infiltrative growth pattern sometimes evident histologically. Recognition of this complex diagnostic entity is important to avoid misdiagnosis and inappropriate investigation. There is a clinical association with endometriosis and past pelvic surg... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5176839 Mon, 29 Aug 2011 23:00:00 +0100 5176839 http://www.medworm.com/index.php?rid=5176838&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F4%2F544%3Frss%3D1 Prostate involvement by intravascular large B-cell lymphoma (IVLBL) is extremely rare. Until now, only 6 cases have been reported in the literature. In this article, the authors report a case of a 65-year-old Chinese man with IVLBL located in the prostate. The diagnosis of IVLBL was obtained incidentally from a biopsy of his prostatectomy specimen. The patient underwent CHOP therapy for 5 cycles and had a favorable clinical outcome. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5176838 Mon, 29 Aug 2011 23:00:00 +0100 5176838 http://www.medworm.com/index.php?rid=5176837&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F4%2F538%3Frss%3D1 Marked involvement of bronchial epithelium by malignant cells with a neuroendocrine immunophenotype was observed in a pulmonary lobectomy specimen containing combined small cell lung carcinoma (SCLC). Review of the medical literature reveals scant information on malignant neuroendocrine cells in bronchial epithelium accompanying SCLC and no documentation of an SCLC precursor. We discuss the possibility that the intraepithelial neoplastic lesion that we have described may be a primary lesion and possibly a precursor of SCLC and the alternative possibility that it represents invasion by underlying invasive SCLC. The need for further comprehensive study of the morphology and immunophenotype of bronchial mucosal abnormalities accompanying SCLC utilizing lung resection specimens is emphasized. ... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5176837 Mon, 29 Aug 2011 23:00:00 +0100 5176837 http://www.medworm.com/index.php?rid=5176836&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F4%2F534%3Frss%3D1 Two cases are presented in which microscopic groups of retroperitoneal paraganglionic cells simulated metastatic seminomatous tumor. Both patients had histories of mixed testicular germ cell tumor with abdominal metastases and had been treated with chemotherapy. Persistent retroperitoneal disease was favored on follow-up imaging studies. Subsequent retroperitoneal lymph node dissection disclosed multifocal epithelioid cell groups with clear/vacuolated cytoplasm in the fibroconnective and adipose tissue, ranging from 1.0 to 3.0 mm in size. These cell groups were initially interpreted as recurrent metastatic seminoma, but were later reinterpreted as paraganglionic cells, which were confirmed by immunohistochemical analysis. The pathologic features for distinguishing paraganglionic cells from... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5176836 Mon, 29 Aug 2011 23:00:00 +0100 5176836 http://www.medworm.com/index.php?rid=5176835&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F4%2F527%3Frss%3D1 Adnexal tumors with follicular differentiation in the breast parenchyma are rarely encountered. The authors present a unique case arising in a 64-year-old woman, in whom they observed composite differentiation toward follicular germinative cells of the hair follicle with focal areas of outer root sheath differentiation and pilar-type keratinization. The histogenesis of this tumor is analyzed in light of the peculiar pathological, immunohistochemical, and molecular genetic findings. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5176835 Mon, 29 Aug 2011 23:00:00 +0100 5176835 http://www.medworm.com/index.php?rid=5176834&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F4%2F524%3Frss%3D1 A case of extensive ganglioneuromatosis (GN) of gallbladder is presented. A 38-year-old man presented with a hepatic hilar mass ( ~ 48 mm) and gall stones. He had undergone total thyroidectomy for medullary thyroid carcinoma 8 years earlier. The hepatic hilus tumor, which had been clinically suspected to be a lymph node metastasis from the medullary thyroid carcinoma, was found to be pheochromocytoma. The gallbladder, resected with a clinical diagnosis of cholelithiasis, showed extensive transmural GN despite a grossly normal appearance. Taking into account the past history, the patient was diagnosed as having multiple endocrine neoplasia 2b (MEN2b)–associated GN of gallbladder and ectopic pheochromocytoma. As GN of gallbladder in MEN2b has been rarely reported, the histological find... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5176834 Mon, 29 Aug 2011 23:00:00 +0100 5176834 http://www.medworm.com/index.php?rid=5176833&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F4%2F521%3Frss%3D1 The authors report here a case of in situ follicular lymphoma (FL) associated with progressive transformation of the germinal center (PTGC). A 39-year-old Japanese male developed a mass in the right cervical region. Biopsy of the enlarged lymph node led to a diagnosis of PTGC. Then, 5 years later, the lymphadenopathy recurred. The second biopsy specimens contained numerous germinal centers, including PTGC. Although most follicles were cytologically reactive, a few GCs appeared to be somewhat monotonous, composed predominantly of centrocytes and lacking mitotic figures and tangible body macrophages. Immunohistochemical studies demonstrated that these atypical GCs were CD10+, CD20+, and bcl-2+, with -light-chain restriction. A previous report emphasized the differential diagnostic problem be... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5176833 Mon, 29 Aug 2011 23:00:00 +0100 5176833 http://www.medworm.com/index.php?rid=5176832&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F4%2F518%3Frss%3D1 Intravascular papillary endothelial hyperplasia (IPEH) is a benign, florid proliferation of endothelial cells forming hyaline papillae covered by monolayered cells, which has rarely been described in the renal vein, most often being equated to tumors because of the difficulties in correctly interpreting imaging findings and accordingly treated by nephrectomy. If the kidney is end-staged for preexisting medical diseases, the risk of overtreatment is obviously negligible, but overdiagnosing IPEH as an intravascular tumor, either benign or malignant, may be perilous for the patient because of the possible consequences on the clinical management. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5176832 Mon, 29 Aug 2011 23:00:00 +0100 5176832 http://www.medworm.com/index.php?rid=5176831&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F4%2F514%3Frss%3D1 Only one case of lymphoepithelioma-like carcinoma of the ovary has been reported so far. A new case is herein illustrated in a 69-year-old woman: an ovarian mass adherent to urinary bladder dome with peritoneal carcinomatosis. Histologically, undifferentiated carcinomatous areas were intermingled with abundant lymphoid tissue. Epstein-Barr virus has not been detected either in neoplastic or in lymphoid cells. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5176831 Mon, 29 Aug 2011 23:00:00 +0100 5176831 http://www.medworm.com/index.php?rid=5176830&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F4%2F510%3Frss%3D1 The authors describe the case of a 36-year-old man with gynecomastia who was previously treated with liposuction of the breast for cosmetic purposes. Histologic examination of a subsequent excisional biopsy revealed nests of displaced epithelial cells in adipose tissue. Epithelial cell displacement is a well-known risk of core needle biopsies and fine-needle aspirations of breast lesions. However, to the authors’ knowledge, epithelial displacement in gynecomastia after liposuction, mimicking invasive ductal carcinoma, has not previously been reported. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5176830 Mon, 29 Aug 2011 23:00:00 +0100 5176830 http://www.medworm.com/index.php?rid=5176829&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F4%2F506%3Frss%3D1 The authors describe a case of renal cell carcinoma with t(6; 11) (p21; q12) in a 22-year-old man. The tumor showed typical histological features of this neoplasm with 2 types of cells and hyaline nodules surrounded by small cells. Characteristically, the tumor showed cystic lumina with hyaline-papillary structures inside and in some areas large and irregular intratumoral vessels. On immunohistochemical study, the tumoral cells were positive for melanocytic markers and transcription factor EB, as also for AE1-AE3 and Cam5.2 anticytokeratin antibodies. The expression of epithelial markers in this neoplasm is uncommon, and we think it is an important finding because otherwise, if melanocytic markers such as HMB45 or Melan A are not used, some renal cell carcinomas with the t(6; 11) (p21; q12... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5176829 Mon, 29 Aug 2011 23:00:00 +0100 5176829 http://www.medworm.com/index.php?rid=5176828&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F4%2F502%3Frss%3D1 Follicular dendritic cell (FDC) sarcoma, especially of extranodal origin, is an extremely rare malignancy of FDC origin, with only 1 case previously documented in the thyroid. The authors report the case of a 58-year-old female who presented with a painless mass in her neck. The neoplastic cells expressed monocyte/macrophage-specific marker CD68 (KP-1) and lysozymes and the dendritic cell-associated antigens CD35 and Fascin but was negative for CD1a, CD21, and CD23, most consistent with a diagnosis of FDC sarcoma. BIOMED-2 multiplex polymerase chain reaction analysis showed B-cell clonality in both tumor and its adjacent coexisting Hashimoto’s thyroiditis. To the authors’ knowledge, this is the first report of a rare entity of FDC sarcoma primarily involving the thyroid gland c... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5176828 Mon, 29 Aug 2011 23:00:00 +0100 5176828 http://www.medworm.com/index.php?rid=5176827&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F4%2F499%3Frss%3D1 Glomus tumors are neoplasms differentiating toward specialized cells found in the glomus body, a structure involved in thermoregulation. Although the vast majority is benign, the occurrence of malignant glomus tumors is well recognized. Criteria for prediction of malignant potential include a deep location, large size, infiltration, necrosis, and nuclear atypia. Symplastic glomus tumors are benign neoplasms showing striking nuclear pleomorphism in the absence of other malignant criteria. Recognition of this rare morphologic aberration would prevent an inadvertent diagnosis of malignancy. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5176827 Mon, 29 Aug 2011 23:00:00 +0100 5176827 http://www.medworm.com/index.php?rid=5176826&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Freprint%2F19%2F4%2F497%3Frss%3D1 (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5176826 Mon, 29 Aug 2011 23:00:00 +0100 5176826 http://www.medworm.com/index.php?rid=5176825&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Freprint%2F19%2F4%2F494%3Frss%3D1 (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5176825 Mon, 29 Aug 2011 23:00:00 +0100 5176825 http://www.medworm.com/index.php?rid=5176824&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Freprint%2F19%2F4%2F492%3Frss%3D1 (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5176824 Mon, 29 Aug 2011 23:00:00 +0100 5176824 http://www.medworm.com/index.php?rid=5176823&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F4%2F487%3Frss%3D1 The presence of "crushing" artifacts in histological sections is a very common finding and represents a potentially major pitfall for the surgical pathologist, particularly in small biopsy specimens. Microscopically, it appears as bluish clusters in which the cellular details are not recognizable. Here the authors report examples of this phenomenon that have been reported or that they have personally observed and emphasize some diagnostic clue to avoid its overinterpretation and the dire clinical consequences that this may entail. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5176823 Mon, 29 Aug 2011 23:00:00 +0100 5176823 http://www.medworm.com/index.php?rid=5176822&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F4%2F476%3Frss%3D1 Solitary fibrous tumor (SFT) of the central nervous system was first described in 1996. A number of cases have been reported since. The authors present 5 new cases: 4 intracranial and 1 intraspinal. All patients were adults (age range, 47 to 75 years); 4 were male and 1 female; 4 cases were primary tumors; and 1 was a second tumor recurrence. All patients were surgically treated with gross total removal. All cases were histologically examined with immunohistochemical confirmation; 2 tumors exhibited diffuse classic histology, 1 tumor was a cellular variant, 1 tumor was myxoid, and 1 was predominantly classic with focal myxoid features and focally pleomorphic. The postoperative course was uneventful in all. The patient with the cellular variant experienced 2 local recurrences and eventually... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5176822 Mon, 29 Aug 2011 23:00:00 +0100 5176822 http://www.medworm.com/index.php?rid=5176821&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F4%2F469%3Frss%3D1 Tonsil excision is a common surgery for both children and adults. Prior studies have consistently shown that the rate of malignancy in tonsil specimens is low and that the possibility of true, occult malignancy is remote. Practice trends accept triage of pediatric tonsillectomies for exemption or gross exam only. However, for adults, despite a low malignancy rate, routine histological evaluation of tonsillectomy specimens is standard of care at most health care facilities. The authors performed a retrospective review of all tonsil specimens received in their department over 45 months with categorization of pathological diagnosis and surgical indication. Of 1746 adult tonsillectomy specimens removed during this time, there were no incidental/occult malignancies. These data indicate that gro... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5176821 Mon, 29 Aug 2011 23:00:00 +0100 5176821 http://www.medworm.com/index.php?rid=5176820&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F4%2F462%3Frss%3D1 In this study of 391 patients, the authors aim to determine the optimal node counts in patients with colorectal cancer, examine for correlations between maximum tumor diameter and lymph node yield, and examine for correlations between lymph node yield and involved node numbers. Furthermore, the authors aim to examine the impact of specimen type on the harvested node numbers and assess whether the personal differences between surgeons and pathologists have significant influence on node yield. A moderate positive correlation between maximum tumor diameter and final lymph node yield was noted (Spearman’s correlation coefficient = .328, P = .0001). There was significant variation shown by pathologists (Kruskal–Wallis test P = .001) and by differing specimen type (Kruskal–Wall... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5176820 Mon, 29 Aug 2011 23:00:00 +0100 5176820 http://www.medworm.com/index.php?rid=5176819&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F4%2F448%3Frss%3D1 In conclusion, complete clinicopathological, immunohistochemical, and genetic descriptions are necessary to characterize this disease and optimize its clinical management. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5176819 Mon, 29 Aug 2011 23:00:00 +0100 5176819 http://www.medworm.com/index.php?rid=5176818&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F4%2F441%3Frss%3D1 Conclusion. PB-type ampullary cancers were more aggressive than I-type carcinomas. MUC1 and MUC2 expression was useful for classification as PB or I type. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5176818 Mon, 29 Aug 2011 23:00:00 +0100 5176818 http://www.medworm.com/index.php?rid=5176817&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F4%2F433%3Frss%3D1 Conclusion. Reduced and cytoplasmic localization of β-catenin could indicate lack of differentiation, invasive potential, and aggressive behavior in malignant salivary gland tumors. Furthermore, change in expression based on the arrangement of tumor cells may suggest that β-catenin may have a role in morphological variations seen in PAs. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5176817 Mon, 29 Aug 2011 23:00:00 +0100 5176817 http://www.medworm.com/index.php?rid=5176816&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F4%2F425%3Frss%3D1 In conclusion, HER-2 IHC3+/FISH– breast cancer could be a subgroup showing lower histological/nuclear grade and higher expression of ERs/PRs. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5176816 Mon, 29 Aug 2011 23:00:00 +0100 5176816 http://www.medworm.com/index.php?rid=5176815&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F4%2F417%3Frss%3D1 Conclusion. The results do not support the prognostic value of GCB and non-GCB immunohistochemical categories in DLBCL of both nodal and extranodal origin. Furthermore, a limited number of antigens may be not sufficient to identify the same patterns defined by cDNA microarray. Prospective studies are warranted to address this issue. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=5176815 Mon, 29 Aug 2011 23:00:00 +0100 5176815 http://www.medworm.com/index.php?rid=4916044&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F3%2F412%3Frss%3D1 The author names on the title page are currently appearing as: Pagni Fabio and Di Bella Camillo The correct order is as follows: Fabio Pagni and Camillo Di Bella (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4916044 Thu, 09 Jun 2011 23:00:00 +0100 4916044 http://www.medworm.com/index.php?rid=4916042&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Freprint%2F19%2F3%2F409%3Frss%3D1 (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4916042 Thu, 09 Jun 2011 23:00:00 +0100 4916042 http://www.medworm.com/index.php?rid=4916041&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F3%2F405%3Frss%3D1 This article reports a patient presenting with marked leukocytosis with profound peripheral eosinophilia initially thought to be related to a chronic myeloproliferative disorder, likely chronic eosinophilic leukemia. After further diagnostic evaluation, ALCL was noted in the bone marrow, masked by the myeloid hyperplasia and eosinophilia. This case emphasizes the importance of a full diagnostic workup for T-cell malignancies, including ALCL rather than focusing on the far less common eosinophilia-associated myeloid malignancies in the clinicopathologic setting of marked eosinophilia. Moreover, bone marrow involvement by ALCL is exceedingly rare and when noted, presents as one or more localized lytic lesions. This is the first reported case of ALCL primarily involving bone marrow without ra... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4916041 Thu, 09 Jun 2011 23:00:00 +0100 4916041 http://www.medworm.com/index.php?rid=4916040&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F3%2F401%3Frss%3D1 Criteria for the very rare diagnosis of primary seminal vesicle carcinoma have traditionally been highly stringent but may be relaxed with the application of immunohistochemistry to the diagnosis of mass lesions that occur in the male pelvis. The authors report a case of disseminated carcinoma with a clinically occult primary site that apparently had its origin in the seminal vesicle. Autopsy revealed a 10-cm tumor enveloping the prostate and seminal vesicles without involvement of colonic or urothelial mucosa. Much smaller tumors were present in other sites outside the pelvis. The tumor was composed of poorly formed glands and sheets of malignant-appearing cells, involved the seminal vesicle, and had the immunohistochemical profile of seminal vesicle carcinoma, notably strong immunoreacti... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4916040 Thu, 09 Jun 2011 23:00:00 +0100 4916040 http://www.medworm.com/index.php?rid=4916039&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F3%2F398%3Frss%3D1 Testicular hemangiomas are benign vascular neoplasms usually occurring in children. Pathologists must be aware of this entity when performing intraoperative frozen sections as, after diagnosis, testicle-sparing surgery is adequate. The authors present a typical case with immunohistochemical studies and a review of the literature. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4916039 Thu, 09 Jun 2011 23:00:00 +0100 4916039 http://www.medworm.com/index.php?rid=4916038&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F3%2F393%3Frss%3D1 This study reports the sixth case of a glomus tumor arising in the kidney in a 62-year-old man who presented with weight loss and an incidental kidney lesion detected by computed tomographic scan. Radiologically, the tumor was difficult to differentiate from a malignant lesion and was therefore excised by partial nephrectomy. The tumor was challenging to diagnose by routine hematoxylin and eosin microscopic examination, necessitating immunohistochemical analysis. Immunoreactivity was demonstrated for smooth muscle actin, vimentin, collagen IV, and CD57, with little to no expression of neuroendocrine, endothelial, or epithelial markers. To date, the tumor has followed a benign course without evidence of local recurrence or metastasis. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4916038 Thu, 09 Jun 2011 23:00:00 +0100 4916038 http://www.medworm.com/index.php?rid=4916037&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F3%2F386%3Frss%3D1 Pediatric cryptococcosis has been documented in various organs, but pediatric renal cryptococcosis (RC) remains undocumented to date. The authors report RC in 2 children with AIDS, 7 and 9 years of age, with proteinuria. Both patients, on antiretroviral therapy (ARV) for 28 (patient 1) and 54 (patient 2) weeks each, had secured viral immunosuppression, but immune restoration was realized by patient 1 only. Cryptococcal immune reconstitution inflammatory syndrome (IRIS) was diagnosed on the renal biopsy from patient 1 based on the clinicopathological profile and the presence of segmental glomerular and an interstitial lymphoplasmacytic and granulomatous reaction to Cryptococcus neoformans, with a predominance of capsule-deficient fungal forms. The renal biopsy from patient 2 demonstrated ty... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4916037 Thu, 09 Jun 2011 23:00:00 +0100 4916037 http://www.medworm.com/index.php?rid=4916036&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F3%2F382%3Frss%3D1 Benign epithelial and nonepithelial inclusions have been found in lymph nodes in multiple body sites. These inclusions have been seen in cervical, axillary, mediastinal, abdominal, and pelvic lymph nodes. They appear as benign epithelial, parathyroid, decidual, mesothelial, angiolipomatous, nevus cells, or Tamm—Horsfall protein. Although heterotopic salivary gland tissue is not infrequent in paraparotid lymph nodes, it has only been described in lymph nodes of the pulmonary hilum once. A 68-year-old woman with gastric lymphoma now in remission presented for routine follow-up and was found to have a lung mass. After a fine needle aspiration biopsy diagnosis of adenocarcinoma, lobectomy and lymph node dissection were performed. Histological sections of lung demonstrated a well-differen... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4916036 Thu, 09 Jun 2011 23:00:00 +0100 4916036 http://www.medworm.com/index.php?rid=4916035&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F3%2F377%3Frss%3D1 This study reports a patient with composite synchronous biclonal occurrence of MALT lymphoma of the lung and CLL/SLL. The morphology of the lung and peripheral blood showed features of MALT lymphoma and CLL, respectively. The cytogenetic evaluation of the lung specimen revealed a t(1;14) (p22;q32), a frequent genetic abnormality in MALT lymphoma. Flow cytometry analysis of the lung tissue showed features of MALT lymphoma and CLL/SLL with different light chain restriction, whereas the blood showed phenotypic evidence of CLL/SLL. Fluorescence in situ hybridization study of the blood showed a deletion of 13q14 and 17p13. Immunoglobulin heavy chain (IgH) gene rearrangement study of the lung tissue and blood showed a monoclonal IgH gene rearrangement with distinct light chain restriction, sugge... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4916035 Thu, 09 Jun 2011 23:00:00 +0100 4916035 http://www.medworm.com/index.php?rid=4916034&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F3%2F373%3Frss%3D1 Cokeromyces recurvatus is a dimorphic zygomycete with histologic morphology similar to Coccidioides immitis. A 66-year-old man who was status-post bone marrow transplantation for chronic myelogenous leukemia was hospitalized with new onset rash, nausea, and vomiting and subsequently expired. A sputum culture collected on the day of death revealed heavy growth of C. recurvatus 6 days after collection. At autopsy, microscopic examination of the lungs revealed numerous thick-walled, nonbudding spherules ranging in size from 40 to 80 µm. Initial immunohistochemical staining of the formalin-fixed lung tissue was positive for Coccidioides . Additional immunoperoxidase staining revealed the organisms were consistent with a zygomycete fungus, compatible with C. recurvatus infection. Polymera... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4916034 Thu, 09 Jun 2011 23:00:00 +0100 4916034 http://www.medworm.com/index.php?rid=4916033&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F3%2F369%3Frss%3D1 Chronic sclerosing dacryoadenitis and chronic sclerosing sialadenitis have been shown to belong to the group of diseases referred to as IgG4-related sclerosing disease. The authors report a case of the simultaneous occurrence of IgG4-related sclerosing disease in both lacrimal and submandibular glands, clinically simulating malignant lymphoma. A cervical lymph node and a Warthin’s tumor were also involved. This unique case of multiple organ involvement in IgG4-related sclerosing disease is documented. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4916033 Thu, 09 Jun 2011 23:00:00 +0100 4916033 http://www.medworm.com/index.php?rid=4916032&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F3%2F366%3Frss%3D1 Warthin tumor (papillary cystadenoma lymphomatosum) is a benign salivary gland tumor involving almost exclusively the parotid gland. The lip is a very unusual location for this type of tumor, which develops only rarely in minor salivary glands. The case of 42-year-old woman with Warthin tumor arising in minor salivary glands of the upper lip is reported. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4916032 Thu, 09 Jun 2011 23:00:00 +0100 4916032 http://www.medworm.com/index.php?rid=4916031&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F3%2F364%3Frss%3D1 Heterotopic gastric mucosa in the gallbladder is rare (with about 100 reported cases), and its occurrence is even rarer in the biliary ductal system.The authors report a pediatric case of heterotopic gastric mucosa in the cystic duct associated with cholelitiasis. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4916031 Thu, 09 Jun 2011 23:00:00 +0100 4916031 http://www.medworm.com/index.php?rid=4916030&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F3%2F359%3Frss%3D1 An unusual case of acute abdomen was caused by the inflammation of ectopic pancreatic tissue in a Meckel’s diverticulum. A 49-year-old man presented with acute abdominal pain, and the clinical diagnosis of acute appendicitis was established. During laparotomy, a normal appendix of unusual localization near the gallbladder and a Meckel’s diverticulum with an inflamed tip were found. Histological examination showed acute inflammation of heterotopic pancreatic tissue along with normal ectopic gastric and duodenal mucosa within the wall of the diverticulum. Fat necrosis was also ascertained. The authors believe that this is the first report of acute inflammation of ectopic pancreatic tissue and the presence of normal ectopic gastric and duodenal tissue in the same Meckel’s di... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4916030 Thu, 09 Jun 2011 23:00:00 +0100 4916030 http://www.medworm.com/index.php?rid=4916029&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F3%2F355%3Frss%3D1 This report describes such an occurrence in a gastric large cell neuroendocrine carcinoma of a 77-year-old man. The patient presented with dyspepsia, and biopsy of the fungating mass in the cardia showed a high grade neuroendocrine carcinoma. The pre-operative biopsy taken after 3 months showed chronic inflammation and cytomegalovirus inclusions, but no tumour. In the gastrectomy specimen, no residual tumour was found. Instead, there were foamy histiocytes, chronic inflammatory cells and fibrovascular tissue splitting apart the muscularis propria. In addition, there was ganglionitis involving the myenteric plexus, even in areas of the stomach away from the inflamed site. Chemotherapy, radiotherapy or alternative medicine (including herbal medicine) had not been given. We postulate that cyt... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4916029 Thu, 09 Jun 2011 23:00:00 +0100 4916029 http://www.medworm.com/index.php?rid=4916028&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F3%2F348%3Frss%3D1 This study presents a case of intraoral BCC arising in the anterior buccal mucosa of a patient with nevoid basal cell carcinoma syndrome (NBCCS), which represents a previously unreported clinical finding, to our knowledge. Histopathologic and immunohistochemical features of the case were compared to examples of PA, conventional intraosseous ameloblastoma, sporadic cutaneous BCC and cutaneous BCC from NBCCS patients. Ber-EP4 expression by the oral tumor was distinct from both peripheral and intraosseous forms of ameloblastoma and was identical to cutaneous BCC in both sporadic and syndromic settings. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4916028 Thu, 09 Jun 2011 23:00:00 +0100 4916028 http://www.medworm.com/index.php?rid=4916027&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Freprint%2F19%2F3%2F346%3Frss%3D1 (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4916027 Thu, 09 Jun 2011 23:00:00 +0100 4916027 http://www.medworm.com/index.php?rid=4916026&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Freprint%2F19%2F3%2F342%3Frss%3D1 (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4916026 Thu, 09 Jun 2011 23:00:00 +0100 4916026 http://www.medworm.com/index.php?rid=4916025&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F3%2F335%3Frss%3D1 This study shows that the first significant increase in angiogenesis occurs very early in the evolution of ductal proliferations as ductal cells become hyperplastic. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4916025 Thu, 09 Jun 2011 23:00:00 +0100 4916025 http://www.medworm.com/index.php?rid=4916024&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F3%2F328%3Frss%3D1 This study evaluates frequency and patterns of occult nipple involvement in a large contemporary cohort of patients, aiming to improve patient selection for NSM. A total of 2323 consecutive mastectomy specimens with grossly unremarkable nipples were evaluated by sagittal sections through the entire nipple and subareolar tissue. Sixteen different clinical and tumor parameters were examined to predict cancerous nipple involvement. Nipple involvement was noted in 331 of 2323 (14.2%) mastectomy specimens. Occult nipple involvement rate was 10.7% (248 cases). Occult nipple involvement usually occurs as ductal carcinoma in situ. In univariate analysis, patient age, tumor size, tumor-to-nipple distance, tumor central location, tumor type, lymph node status, lymphatic vascular invasion, histologic... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4916024 Thu, 09 Jun 2011 23:00:00 +0100 4916024 http://www.medworm.com/index.php?rid=4916023&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F3%2F321%3Frss%3D1 Teratoma with a malignant somatic component (MSC) is a rare phenomenon recognized when a somatic type malignancy occurs in the context of a germ cell tumor (GCT). The authors present their 29-year experience with 40 patients treated from 1981 to 2009 in their institution. The average age was 31 years. All patients underwent radical orchiectomy, which demonstrated a GCT in 19 with an MSC. The MSC was observed in the other 21 cases in metastatic sites, including lung (13), liver (3), pleura (1), mediastinum (7), supraclavicular lymph nodes (1), and retroperitoneal lymph nodes (9). The most common histologic types were rhabdomyosarcoma (n = 11) and primitive neuroectodermal tumors (n = 10), followed by adenocarcinoma (n = 9), sarcoma, not otherwise specified (n = 5), well-differentiated lipos... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4916023 Thu, 09 Jun 2011 23:00:00 +0100 4916023 http://www.medworm.com/index.php?rid=4916022&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F3%2F315%3Frss%3D1 This study was conducted to find the number, size, and distribution of the lymph nodes in the mesorectum in fresh cadavers without rectal cancer in Indians and to compare fat clearance method versus manual dissection of lymph nodes in terms of efficacy of lymph node yield. Thirty fresh cadavers underwent total mesorectal excision (TME) by midline incision. TME specimen was divided transversely (upper, middle, and lower thirds), and then further divided radially into 4 equal areas and the right lateral, left lateral, and posterior areas were taken for lymph node harvesting. In the first 15 cases (group A), lymph nodes were dissected manually from each of 9 areas. Number and diameters of harvested nodes were noted, and specimens were histopathologically examined. In the next 15 cases (group ... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4916022 Thu, 09 Jun 2011 23:00:00 +0100 4916022 http://www.medworm.com/index.php?rid=4916021&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F3%2F309%3Frss%3D1 This study compares p16 INK4a immunohistochemistry (IHC), HPV chromogenic in situ hybridization (ISH), and HPV polymerase chain reaction (PCR) genotyping for detection of HPV infection in basaloid squamous carcinoma (BSCC). A retrospective histopathological analysis of 40 BSCC from a single institution was carried out. p16 IHC, HPV DNA extraction and ISH, and HPV PCR genotyping were performed, and there was excellent agreement between all 3 methods of HPV detection. Analysis of variance yielded no significant differences between the results of the 3 tests ( P = .354) and Pearson product—moment correlation coefficients calculated for each pair of tests demonstrated direct correlation (r = .61 for PCR and IHC, r = .61 for PCR and ISH, and r = 1.00 for ISH and IHC). This supports the us... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4916021 Thu, 09 Jun 2011 23:00:00 +0100 4916021 http://www.medworm.com/index.php?rid=4916020&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F3%2F303%3Frss%3D1 Conclusions . The study revealed evident differences in the positive expression of nerve markers in the enteric sections when TCA and common-segment HD were compared, indicating differences in enteric nerve innervation in these conditions. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4916020 Thu, 09 Jun 2011 23:00:00 +0100 4916020 http://www.medworm.com/index.php?rid=4916019&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F3%2F297%3Frss%3D1 Immunohistochemical staining is useful in the diagnosis of Helicobacter pylori—induced gastritis. The authors encountered gastric resection specimens with an unusual pattern of reactivity on H pylori immunostains where the typical morphology of the organism was not recognizable, but the characteristic chronic gastritis associated with infection was present. The authors sought to explore this phenomenon by retrospectively reviewing and immunostaining 28 gastric resection specimens for H pylori. Six cases with large clumps of immunohistochemically positive but morphologically unrecognizable material were identified on light microscopy, corresponding on electron microscopy to clusters of predominantly coccoid H pylori, some located intracellularly. Such organisms were not identifiable w... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4916019 Thu, 09 Jun 2011 23:00:00 +0100 4916019 http://www.medworm.com/index.php?rid=4916018&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F3%2F290%3Frss%3D1 Our aims were to evaluate (a) whether the incidence of eosinophilic esophagitis (EE) in children has increased, (b) whether the histologic diagnosis of EE has been accurate, and (c) potential interobserver variability in the counting of intraepithelial eosinophils in esophageal biopsies. A total of 1215 pediatric endoscopic esophageal biopsies were performed. In total, 289 biopsies were reviewed by one pathologist based on one of the following original histologic diagnoses: EE, reflux esophagitis (RE), or acute/chronic inflammation. EE was diagnosed when at least one high-power field (HPF) contained > or = 20 intraepithelial eosinophils. According to the first pathologist, 104 biopsies had a histologic diagnosis of EE; the prevalence remained relatively stable, ranging from 5.5 to 11 pe... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4916018 Thu, 09 Jun 2011 23:00:00 +0100 4916018 http://www.medworm.com/index.php?rid=4916017&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F3%2F285%3Frss%3D1 Melanotic Xp11 translocation renal cancer is a recently recognized aggressive epithelioid neoplasm with features overlapping between PEComa, carcinoma, and melanoma, in which TFE3 gene fusions coexist with melanin synthesis. These findings support the idea that melanotic Xp11 translocation renal cancer is a distinct variant of the MiT/TFE3 family neoplasms. The authors describe a pigmented renal tumor occurring in a 30-year-old woman with distinct morphology and immunohistochemical characteristics as Xp11 translocation renal cancer. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4916017 Thu, 09 Jun 2011 23:00:00 +0100 4916017 http://www.medworm.com/index.php?rid=4688722&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F2%2F276%3Frss%3D1 This study describes an encapsulated thyroid tumor having 3 different concentric appearances in a 70-year-old man. The most peripheral neoplasm showed features of a microfollicular adenoma; the intermediate lesion displayed typical features of the follicular variant of papillary thyroid carcinoma (FVPTC); and the main, central neoplasm, showed a basaloid configuration. At variance with the other neoplasms, the latter component exhibited high mitotic activity. Necrosis, angio-invasion, or capsular invasions were not observed. The centrally located neoplasm was immunoreactive for several cytokeratins, p63, carcinoembryonic antigen, and galectin-3, and negative for thyroid transcription factor 1, thyroglobulin, calcitonin, CD5, and CK20, featuring a phenotype similar to that of thyroid solid ... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4688722 Wed, 06 Apr 2011 23:00:00 +0100 4688722 http://www.medworm.com/index.php?rid=4688721&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F2%2F273%3Frss%3D1 Combined lung cancers containing both small cell and non—small cell carcinoma elements are uncommon but well recognized. Lung tumors with neuroendocrine differentiation form a group of histologically distinct tumors with differing clinical behavior ranging from low-grade tumors with good prognosis (typical carcinoid) to intermediate-grade tumors (atypical carcinoid) to high-grade tumors with poor prognosis (small cell carcinoma and large cell neuroendocrine tumors). The authors report clinical findings and pathologic findings in a case of combined carcinoid tumor and squamous cell carcinoma of lung. To the best of the authors’ knowledge, this is the first report of such a case in the peer reviewed literature, thus broadening the spectrum of combined lung tumors. (Source: Intern... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4688721 Wed, 06 Apr 2011 23:00:00 +0100 4688721 http://www.medworm.com/index.php?rid=4688720&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F2%2F268%3Frss%3D1 Calcifying nested stromal—epithelial tumor (CNSET) of the liver is extremely rare. This tumor is characterized by nests of epithelial and spindle cells, an associated desmoplastic stroma, as well as variable calcifications and ossifications. Only 24 cases have been reported in the literature whereas none has been reported in Asian descendants. The authors report the first case of CNSET in a 34-year-old Asian woman and provide detailed histological and clinical follow-up data. Compared with those reported earlier, the present case with a history of oral contraceptive use displayed most typical features and the oldest age of onset. A retrospective study was made and the characteristics of CNSET were summarized. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4688720 Wed, 06 Apr 2011 23:00:00 +0100 4688720 http://www.medworm.com/index.php?rid=4688719&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F2%2F263%3Frss%3D1 An 82-year-old man, with 6-year history of radical prostatectomy followed by radiotherapy performed for prostatic carcinoma, underwent transurethral resection of a papillary tumor of the bladder lateral walls. Histologically, the lesion displays 2 distinct components: epithelial and stromal. The epithelial component was composed of a noninvasive papillary urothelial carcinoma, predominantly low grade and focally high grade. The stromal component exhibited extensive myxoid changes with increased cellularity but lacking cellular atypia and mitoses. The epithelial component was immunoreactive for pan-cytokeratins and negative for smooth muscle actin (SMA) and vimentin. The stromal component exhibited focal positivity for pan-cytokeratins and SMA, and diffuse immunoreactivity for vimentin. The... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4688719 Wed, 06 Apr 2011 23:00:00 +0100 4688719 http://www.medworm.com/index.php?rid=4688718&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F2%2F259%3Frss%3D1 This study reports a patient with endometriosis causing rectal bleeding and involving the cecum. It produced a mass clinically considered appendiceal. The endometriosis was focally lined by intestinal epithelium including Paneth cells. In the deep endometriotic glands embedded within intestinal wall, direct fusion of the intestinal and the endometrial epithelium—the benign intestinal epithelium apparently colonizing the endometriotic foci—was found. The mass effect, plus deep-seated intestinal epithelium, closely mimicked invasive well-differentiated mucinous carcinoma. This is yet another peculiar presentation of endometriosis with potential for misinterpretation as a more serious condition, specifically well-differentiated mucinous carcinoma of the cecum or appendix. (Source:... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4688718 Wed, 06 Apr 2011 23:00:00 +0100 4688718 http://www.medworm.com/index.php?rid=4688717&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F2%2F252%3Frss%3D1 One of the main differential diagnostic issues in pulmonary large-cell carcinomas is that involving neuroendocrine (NE) and basaloid histotypes. The differential diagnosis of basaloid versus large-cell NE carcinoma requires immunohistochemical determination of NE markers because of morphological overlap between the 2 entities. The authors report a unique case of lung carcinoma with basaloid architecture and NE immunohistochemical features observed in a 64-year-old male smoker who underwent upper left lobectomy for a neoplastic stenosis of the lobar bronchus. The patient died 14 months after surgery. Histological examination showed multiple peripheral nodules of moderately enlarged neoplastic cells with irregular nuclei, with granular chromatin and frequent nucleoli, and diffuse in situ neo... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4688717 Wed, 06 Apr 2011 23:00:00 +0100 4688717 http://www.medworm.com/index.php?rid=4688716&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F2%2F247%3Frss%3D1 Myopericytoma is a recently described hemangiopericytoma-like neoplasm with myoid differentiation. These tumors are typically located in the subcutaneous and soft tissues of the extremities. The authors report a rare pleural-based pulmonary myopericytoma in a 58-year-old woman. The lesion was grossly homogeneous and well circumscribed. Microscopically, it was composed of densely packed spindle cells organized as whorls and short interlacing fascicles with a concentric perivascular distribution. Immunohistochemical reactions were positive for vimentin, smooth muscle actin (SMA), muscle-specific actin, and Bcl-2 and negative for desmin, h-caldesmon, cytokeratin, and CD34. Atypically, increased mitotic activity was noted, but no other malignant features were identified. The differential diagn... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4688716 Wed, 06 Apr 2011 23:00:00 +0100 4688716 http://www.medworm.com/index.php?rid=4688715&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F2%2F241%3Frss%3D1 Posttransplant lymphoproliferative disorders (PTLDs) present a wide clinicopathological spectrum, varying from the usual Epstein-Barr virus (EBV)-driven infectious mononucleosis-type polyclonal proliferations to EBV-positive or EBV-negative proliferations indistinguishable from overt lymphomas that occur in immunocompetent individuals. PTLDs characteristically have a predilection for extranodal sites and association with EBV.These disorders are usually B-cell type, although T-cell and rare cases involving both T- and B-cell types have also been described. The initial treatment consists in decreasing the immnosupressive therapy, usually with favorable results. The authors report on a rare case of a 19-year-old girl, with post—renal transplantation EBV-associated polymorphic lymphoprol... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4688715 Wed, 06 Apr 2011 23:00:00 +0100 4688715 http://www.medworm.com/index.php?rid=4688714&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F2%2F235%3Frss%3D1 Primary Hodgkin’s lymphoma (HL) of the stomach is an extremely rare entity. Most cases of gastric involvement by HL are observed in the setting of disseminated disease. The nonspecific nature of the symptoms and endoscopic findings, which include a large malignant-looking ulcer and mass or wall thickening, together with the considerable histological overlap between HLs and some non-HLs or undifferentiated carcinoma, make the surgical resection diagnosis extremely difficult. An accurate diagnosis is important as treatment and outcome differ significantly for these neoplasms. In small endoscopic gastric biopsies and even in postoperative specimens, the precise histological diagnosis of HL is particularly challenging. Here, the authors report 5 cases of 2 women and 3 men aged 22 to 68, ... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4688714 Wed, 06 Apr 2011 23:00:00 +0100 4688714 http://www.medworm.com/index.php?rid=4688713&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Freprint%2F19%2F2%2F230%3Frss%3D1 (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4688713 Wed, 06 Apr 2011 23:00:00 +0100 4688713 http://www.medworm.com/index.php?rid=4688712&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F2%2F225%3Frss%3D1 Primary pulmonary osteosarcoma is very rare. Most cases are secondary deposits from primaries arising in the appendicular skeleton. Four cases of primary osteogenic sarcoma of the lung are described and the literature reviewed for previously reported cases. These pulmonary tumors occur in patients who are in their fourth to seventh decades, that is, an older age group than their primary bone equivalent. There is a slight male predominance. There appears to be a propensity for the left lung, especially the left upper lobe. The clinical presentation is similar to primary (epithelial) lung cancer. Differentiation from pleomorphic carcinomas and other sarcomas is discussed. We know of no predisposing factor(s) in our cases for the development of this tumor. (Source: International Journal of Su... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4688712 Wed, 06 Apr 2011 23:00:00 +0100 4688712 http://www.medworm.com/index.php?rid=4688711&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F2%2F220%3Frss%3D1 This study reports 2 cases of IgG4-related disorder of the retroperitoneum resembling plasma cell type of Castleman’s disease. A single lesion was located in the renal hilum and ureter, respectively, in these 2 cases. Histologically, both lesions were characterized by reactive follicular hyperplasia with active germinal centers and a sheet of polyclonal mature plasma cells in the interfollicular area. The prominent sclerosis and/or fibrosis, which were characteristic histological findings of IgG4-related disorders, were absent. However, immunohistochemical study demonstrated numerous IgG4+ plasma cells accounting for more than 50% of IgG+ cells. The phlebitis that occurs with early lesions of obliterative phlebitis is one of the characteristic histological findings of IgG4-related di... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4688711 Wed, 06 Apr 2011 23:00:00 +0100 4688711 http://www.medworm.com/index.php?rid=4688710&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F2%2F217%3Frss%3D1 Conclusions Metastases of malignant peritoneal mesotheliomas are unusual, and a predominantly gastrointestinal localization is rare. Pathologists should be aware of this possibility to avoid misdiagnosis, particularly in small biopsy specimens. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4688710 Wed, 06 Apr 2011 23:00:00 +0100 4688710 http://www.medworm.com/index.php?rid=4688709&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F2%2F212%3Frss%3D1 We report 2 cases of massive localized lymphedema with unusual presentation. The first case is a recurrent massive localized lymphedema in the right thigh of a 40-year-old morbidly obese woman. In addition to typical massive localized lymphedema features such as prominent edema and vascular proliferation in the adipose tissue, we observed prominent and abundant multinucleated stromal floret-like giant cells, arborizing network of capillaries, and areas of hyalinized collagen. Our second case is in a rare location (scrotum extending into penile soft tissue) in an overweight 55-year-old male. This lesion exhibits striking smooth muscle hyperplasia. Lack of staining by antibodies against murine double minute 2 protein and cyclin dependent kinase 4 and absence of high mobility group AT- hook 2... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4688709 Wed, 06 Apr 2011 23:00:00 +0100 4688709 http://www.medworm.com/index.php?rid=4688708&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F2%2F207%3Frss%3D1 A 56-year-old healthy man noticed a stony-hard mass gradually grown in his neck for more than a 6-year period. Examinations revealed 2 additional calcified masses at the esophageal hiatus and retroperitoneum. The cut-surface of the operative specimens showed fibrous and mucinous appearance with many calcified islands. Microscopically, the lesion showed a gradual transform from the central immature area with fibroblasts and mucinous matrix, to the peripheral mature area with woven bone and osteoclasts (zoning phenomenon), which was compatible with the features of mature myositis ossificans. Myositis ossificans is an isolated, benign, nonneoplastic disease typically found in adolescence, after traumatic episode. Similar lesions have been found in the major musculature of patients with increa... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4688708 Wed, 06 Apr 2011 23:00:00 +0100 4688708 http://www.medworm.com/index.php?rid=4688707&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F2%2F203%3Frss%3D1 A case of a pulmonary sequestration, which almost exclusively consisted of a congenital cystic adenomatoid malformation type II located subdiaphragmatically in the left retroperitoneal area, is reported. This case, in a 24-year-old male patient, is unique in that it appeared as an adrenal incidentaloma and extended through a Bochdalek hernia into the pleural space. It was discovered upon routine ultrasound screening for hepatocellular carcinoma in a patient with a carrier state for hepatitis B. Diagnosis was established only upon histological analysis of the surgically removed tumor after staining with hematoxylin and eosin as well as surfactant A and B. The location of the tumor may indicate that it was formed by an entrapment of a lung bud by the developing diaphragm. This appearance may... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4688707 Wed, 06 Apr 2011 23:00:00 +0100 4688707 http://www.medworm.com/index.php?rid=4688706&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F2%2F199%3Frss%3D1 Only 2 cases of nasopharyngeal small cell carcinoma have been reported. Another case of this rare type of nasopharyngeal tumor confirmed by immunopositivity for CD56, synaptophysin, and chromogranin A is described in this study. The tumor was also negative for cytokeratin (CK) 20 and thyroid transcription factor-1. Clinical investigation did not find any primary tumor in other anatomic sites. Therefore, this case was established as a primary nasopharyngeal small cell carcinoma. Epstein-Barr virus was shown to be absent by Epstein-Barr virus encoded RNA in situ hybridization study in this case, which further distinguished it from conventional nasopharyngeal carcinoma. Clinical features of this case and 2 previously reported cases are compared. They do not differ from conventional nasopharyn... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4688706 Wed, 06 Apr 2011 23:00:00 +0100 4688706 http://www.medworm.com/index.php?rid=4688705&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F2%2F196%3Frss%3D1 Gastritis related to Epstein-Barr virus infection has been rarely reported in the literature. However, one population, arguably, most likely to be infected with the virus (young patients) is unlikely to undergo major diagnostic procedures that would yield pathological specimens containing the characteristic findings. Thus, the disease may be rarely sampled rather than truly rare. Furthermore, any patient with Epstein-Barr virus— related gastritis may manifest clinical and histological findings that can mimic hematolymphoid neoplasia. Therefore, care must be taken and a high level of clinical suspicion employed to avoid a misdiagnosis of lymphoma in these cases. Such a case is reported, with clinicopathological findings and follow-up information indicative of Epstein-Barr virus as the... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4688705 Wed, 06 Apr 2011 23:00:00 +0100 4688705 http://www.medworm.com/index.php?rid=4688704&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Freprint%2F19%2F2%2F194%3Frss%3D1 (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4688704 Wed, 06 Apr 2011 23:00:00 +0100 4688704 http://www.medworm.com/index.php?rid=4688703&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Freprint%2F19%2F2%2F193%3Frss%3D1 (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4688703 Wed, 06 Apr 2011 23:00:00 +0100 4688703 http://www.medworm.com/index.php?rid=4688702&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Freprint%2F19%2F2%2F191%3Frss%3D1 (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4688702 Wed, 06 Apr 2011 23:00:00 +0100 4688702 http://www.medworm.com/index.php?rid=4688701&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Freprint%2F19%2F2%2F190%3Frss%3D1 (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4688701 Wed, 06 Apr 2011 23:00:00 +0100 4688701 http://www.medworm.com/index.php?rid=4688700&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Freprint%2F19%2F2%2F189%3Frss%3D1 (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4688700 Wed, 06 Apr 2011 23:00:00 +0100 4688700 http://www.medworm.com/index.php?rid=4688699&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Freprint%2F19%2F2%2F188%3Frss%3D1 (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4688699 Wed, 06 Apr 2011 23:00:00 +0100 4688699 http://www.medworm.com/index.php?rid=4688698&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F2%2F180%3Frss%3D1 Tenosynovial giant cell tumor (TGCT) arises from the synovium of joints or tendon sheaths. Chondroid metaplasia in TGCT is rare with only 4 well-documented cases reported in the literature. The authors describe the morphological features and immunophenotype of 5 new cases of chondroid TGCT emphasizing a broader range of matrix patterns in these tumors and an expanded immunophenotype, specifically, staining for clusterin and podoplanin which have recently been found to be expressed in conventional TGCTs. Chondroid metaplasia was extensive in 3 cases. Matrix patterns included chondromyxoid, chondro-osseous, hyaline-like, and lace-like calcification similar to that seen in chondroblastoma. The authors conclude that chondroid TGCT is a rare, distinct synovial tumor with a predilection for the ... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4688698 Wed, 06 Apr 2011 23:00:00 +0100 4688698 http://www.medworm.com/index.php?rid=4688697&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F2%2F170%3Frss%3D1 To further study the characteristics of renal cell carcinoma (RCC) in young patients and better define their biological features, 46 RCCs of patients younger than 25 years were morphologically and immunohistochemically characterized with follow-up. Loss of heterozygosity (LOH) analysis of the von Hippel—Lindau (VHL) gene region and screening for VHL gene mutations were performed in all tumors. Applying the 2004 WHO classification for RCC, there were 19 Xp11.2 translocation RCCs, 9 clear cell RCCs, 17 papillary RCCs, and 1 unclassified RCC. All 19 Xp11.2 translocation RCCs showed moderate to strong immunoreactivity for TFE3. None had TFEB immunoreactivity. One Xp11.2 translocation RCC had an unreported morphology with empty or ground glass nuclei, occasional nuclear grooves, inconspic... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4688697 Wed, 06 Apr 2011 23:00:00 +0100 4688697 http://www.medworm.com/index.php?rid=4688696&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F2%2F164%3Frss%3D1 The aim of this study was to describe pathologic features found at autopsy of 14 patients with penile cancer. Nine patients died from disseminated disease; 5 of them presented local/regional recurrences. Five patients died from other causes, 2 of them postoperatively. Local recurrence sites were corpus cavernosum, Buck’s fascia and urethra, regional skin, and prostate. Metastatic sites were lymph nodes (9 cases), liver (7 cases), lungs (6 cases), heart (5 cases), adrenals, bone and skin (3 cases each), thyroid and brain (2 cases each), and pancreas, spleen, and pleura (1 case each). Patients with heart metastasis had arrhythmias. Patients who died and who did not die from penile cancer had different profiles: low-grade superficial tumors with usual and warty subtypes versus high-grad... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4688696 Wed, 06 Apr 2011 23:00:00 +0100 4688696 http://www.medworm.com/index.php?rid=4688695&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F2%2F159%3Frss%3D1 The study determines morphological features that are associated with perineural invasion (PNI) in patients with cervical carcinoma (CX). Histological slides from 194 patients from surgically treated squamous cell carcinoma were re-examined for PNI and correlated to morphological factors of tumor growth. Material from 68 patients (35.1%) represented PNI. PNI was significantly correlated with advanced tumor stage (P < .001). Patients with deep cervical stromal invasion (>66%) showed more PNI than those with more superficial invasion (41% vs 16.9%; P = .001). Tumors with spray-like PI showed significantly more PNI (48.4%) when compared with finger-like PI (26.7%) and those with pushing borders (18.8%; P = .007). Strong peritumoral desmoplastic stromal reaction and absence of peritumoral... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4688695 Wed, 06 Apr 2011 23:00:00 +0100 4688695 http://www.medworm.com/index.php?rid=4688694&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F2%2F152%3Frss%3D1 This study indicates that CD34 and CD117 are differentially expressed in benign and malignant PTs. These markers, therefore, in combination, may be used as an adjunct to morphology in the subclassification of PTs. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4688694 Wed, 06 Apr 2011 23:00:00 +0100 4688694 http://www.medworm.com/index.php?rid=4688693&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F2%2F145%3Frss%3D1 This study found no correlation between the EGFR status and K-ras mutations in colorectal tumors. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4688693 Wed, 06 Apr 2011 23:00:00 +0100 4688693 http://www.medworm.com/index.php?rid=4688692&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F2%2F141%3Frss%3D1 Fine-needle aspiration (FNA) and frozen section evaluation are traditional components of the management of thyroid lesions. Their role and usefulness are dictated by some basic facts about thyroid pathology: (a) nodules are very common; (b ) they are benign in the majority of cases; and (c) the diagnosis of malignancy is primarily based on cytologic features in the case of papillary carcinoma, and on the presence of invasion of the tumor capsule or of blood vessels in the case of follicular carcinoma. The common occurrence of benign thyroid nodules mandates a cost-effective effective method for preoperative screening. Since, as already stated, the diagnosis of papillary thyroid carcinoma (by far the most common thyroid malignancy) is based on the identification of characteristic cytologic ... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4688692 Wed, 06 Apr 2011 23:00:00 +0100 4688692 http://www.medworm.com/index.php?rid=4421030&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F1%2F131%3Frss%3D1 Prostate carcinomas showing aberrant diffuse-nuclear p63 expression are extremely rare, and there is only 1 article in the literature reporting a series of 21 such cases. We document an additional case of p63-positive prostatic adenocarcinoma in a 60-year-old man, whose diagnosis was difficult. The patient was found to have an elevated prostate-specific antigen (PSA) level at a general health check-up and was referred to the hospital. His serum PSA was 4.2 ng/mL. Digital rectal examination and transrectal ultrasonography did not reveal a lesion. Transrectal needle biopsy of the prostate detected atypical, small prostatic glands suspected for adenocarcinoma at 2 cores. However immunohistochemistry showed nuclear p63 expression in the suspicious glands. Repeat biopsy revealed only high-grade... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4421030 Mon, 31 Jan 2011 00:00:00 +0100 4421030 http://www.medworm.com/index.php?rid=4421029&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F1%2F127%3Frss%3D1 Concordant loss of all 3 commonly used melanocytic markers (ie, S-100, HMB-45, and Melan-A) in a primary malignant melanoma with expression of the same in the metastatic lesion is very rare. To the best of the authors’ knowledge, they documented the second case of this unusual and rare phenomenon. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4421029 Mon, 31 Jan 2011 00:00:00 +0100 4421029 http://www.medworm.com/index.php?rid=4421028&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F1%2F123%3Frss%3D1 In conclusion, it is becoming clear that primary neuroblastoma is an important differential diagnostic consideration for a paratesticular mass, particularly in the early pediatric age group. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4421028 Mon, 31 Jan 2011 00:00:00 +0100 4421028 http://www.medworm.com/index.php?rid=4421027&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F1%2F120%3Frss%3D1 This study reports a case of benign Brenner tumor with exuberant dystrophic calcifications that obscured most of the epithelium and posed a diagnostic challenge in differentiating it from the more common malignant counterparts such as serous carcinoma and specifically psammocarcinoma. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4421027 Mon, 31 Jan 2011 00:00:00 +0100 4421027 http://www.medworm.com/index.php?rid=4421026&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F1%2F117%3Frss%3D1 This study reports a case of diffuse large B-cell lymphoma associated with chronic inflammation occurring in a renal pseudocyst: an infrequent neoplasm with an unusual and subtle clinical presentation. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4421026 Mon, 31 Jan 2011 00:00:00 +0100 4421026 http://www.medworm.com/index.php?rid=4421025&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F1%2F113%3Frss%3D1 The authors describe a 52-year-old woman with a history of bilateral mastectomies for macromastia caused by massive nodular pseudoangiomatous stromal hyperplasia (PASH), who presented with 2 large growths in her left axilla and groin. These masses had been increasing in size for nearly a year. When excised, the axillary mass had dimensions of 14.0 x 14.0 x 5.5 cm3 and weighed 664 g. The groin mass was slightly smaller at 14.5 x 11.0 x 5.0 cm3 and 518 g. Microscopic examination of both masses revealed breast tissue expanded by a hyalinized stroma with prominent slit-like pseudovascular spaces, consistent with PASH. Small incidental foci of PASH are common findings in breast excisions; however, large nodular foci are rare. Furthermore, nodular foci in accessory breast tissue are exceedingly ... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4421025 Mon, 31 Jan 2011 00:00:00 +0100 4421025 http://www.medworm.com/index.php?rid=4421024&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F1%2F110%3Frss%3D1 This study reports the case of a poorly differentiated carcinoma of the thyroid that was accompanied by more than 10 foci of pericapsular and peritumoral papillary endothelial hyperplasia, one of which contained a tumor embolus. The vessels within the papillary fronds had CD31- and CD34-staining blood vessels but were lined by D2-40 staining endothelial cells, which were continuous with the lining of the spaces within which PEH had developed. This suggests that, in contrast to Masson’s lesions that develop within blood vessels as a result of thrombosis, pericapsular PEH associated with thyroid neoplasms develops within lymphatics, possibly related to lymphangiogenic factors secreted by the thyroid neoplasms. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4421024 Mon, 31 Jan 2011 00:00:00 +0100 4421024 http://www.medworm.com/index.php?rid=4421023&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F1%2F104%3Frss%3D1 Spindle cell neoplasms arising in the testis are uncommon; most cases belong to the category of gonadal stromal tumors, and the presence of distinctive clinical and pathological features usually lead to a definitive diagnosis. In some instances, however, the diagnosis of these tumors can be challenging and special techniques are needed. The present study reports 2 unusual cases of primary intratesticular tumors showing a striking morphology, characterized by spindle to stellate cells in a lymphoid background. The diagnosis of interdigitating dendritic cell tumor and inflammatory myofibroblastic tumor was established in the 2 cases, and their probable origin in cells of the accessory immune system is discussed. Although both tumors share similar histological features, their immunohistochemi... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4421023 Mon, 31 Jan 2011 00:00:00 +0100 4421023 http://www.medworm.com/index.php?rid=4421022&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F1%2F99%3Frss%3D1 The authors present the first case of a pure osteosarcoma arising in a long-standing uterine leiomyoma along with a literature review of all heterologous sarcomas arising in uterine leiomyoma. Most cases present with abnormal vaginal bleeding and symptoms related to a rapidly enlarged pelvic mass in postmenopausal women with a long-standing history of uterine leiomyoma. The histological finding of the case in this study revealed a relatively well-circumscribed tumor with a peripheral ring of leiomyoma and a central osteosarcoma. The case in this study further supported a possible pathogenesis involving the p53 gene. The prognosis may be better with low-stage tumor; however, cases with advanced stages, larger tumor size at presentation, and histological type of epithelioid angiosarcoma had ... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4421022 Mon, 31 Jan 2011 00:00:00 +0100 4421022 http://www.medworm.com/index.php?rid=4421021&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F1%2F93%3Frss%3D1 This study presents a case of juxtaglomerular cell tumor (JCT) in a 12-year-old girl with hypertension. Fine needle aspirate (FNA) cytology demonstrated a neoplasm with features of a papillary carcinoma, prompting a right radical nephrectomy. Histological examination revealed solid sheets of round epithelioid cells with eosinophilic granular cytoplasm, and distinct cell borders in a background of widespread hemorrhage. Electron microscopy revealed cytoplasmic renin granules. The differential diagnosis of a renal mass in a young patient with hypertension includes JCT, Wilm’s tumor, and renal cell carcinoma, which may produce renin. The renin granules detected by electron microscopy are characteristic of JCT, and the diagnosis is confirmed by ultrastructural study. FNA cytology is not ... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4421021 Mon, 31 Jan 2011 00:00:00 +0100 4421021 http://www.medworm.com/index.php?rid=4421020&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F1%2F88%3Frss%3D1 Interdigitating dendritic cell tumor/sarcoma is an extremely rare neoplasm that mainly occurs in the lymph node, with only 51 cases reported in the literature to date. The authors report the case of a 41-year-old woman who presented with a 4-month history of a gradually enlarging painless mobile lymphadenopathy in the right submaxillary region. The lymph node mass was completely resected and was treated with 1 cycle of CHOP chemotherapy. After 10 months, she was alive with no evidence of disease. Because interdigitating dendritic cell sarcomas are rare and can show morphologic and immunohistochemical heterogeneity, correct diagnosis requires a high index of suspicion and complete pathological study. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4421020 Mon, 31 Jan 2011 00:00:00 +0100 4421020 http://www.medworm.com/index.php?rid=4421019&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F1%2F84%3Frss%3D1 Sclerosing cholangitis is an autoimmune condition characterized by lymphocytic infiltration within the biliary epithelium leading to multifocal stricturing of the biliary tree. Primary sclerosing cholangitis (PSC) is the most common type encountered clinically. However, a similar process may occur in conjunction with autoimmune pancreatitis (AIP), known as AIP-associated sclerosing cholangitis (AIP-SC). This subtype is associated with an elevated IgG4 level and the presence of a number of autoantibodies. AIP-SC shows good response to steroid treatment, distinguishing it clinically from PSC. The authors report a case of AIP-SC in a patient who had previously undergone a biliary bypass for AIP-induced chronic pancreatitis. The presentation of jaundice and grossly elevated tumor marker, CA19.... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4421019 Mon, 31 Jan 2011 00:00:00 +0100 4421019 http://www.medworm.com/index.php?rid=4421018&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F1%2F80%3Frss%3D1 This study reports the case of a 20-year-old woman with an Xp11.2 translocation renal carcinoma that metastasized to the placenta. This is the first reported case of a renal cell carcinoma metastatic to the placenta and highlights the aggressive behavior of Xp11 translocation renal cell carcinomas. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4421018 Mon, 31 Jan 2011 00:00:00 +0100 4421018 http://www.medworm.com/index.php?rid=4421017&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F1%2F75%3Frss%3D1 We describe two cases of thyroiditis due to Cunninghamella bertholletiae diagnosed though a necropsy study and the only five previous cases of thyroid zygomycosis reported in the literature are revised. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4421017 Mon, 31 Jan 2011 00:00:00 +0100 4421017 http://www.medworm.com/index.php?rid=4421016&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F1%2F71%3Frss%3D1 A rare case of pulmonary carcinoid tumor exhibiting morphologically as a monophasic synovial sarcoma is reported. The patient is a 37-year-old man who presented with shortness of breath for several weeks. The chest computed tomographic scan showed a 3.5 cm pulmonary mass in the left lower lobe.The lesion was an oval, tan nodule displaying features of monophasic synovial sarcoma. Immunohistochemical studies were performed and included a carcinoid tumor as a main differential diagnosis. Reverse transcriptase polymerase chain reaction and fluorescence in situ hybridization studies were negative for a molecular evidence of synovial sarcoma. This case further emphasizes the capacity of pulmonary carcinoid tumor cells to show various morphologic expressions even toward a mesenchymal differentiat... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4421016 Mon, 31 Jan 2011 00:00:00 +0100 4421016 http://www.medworm.com/index.php?rid=4421015&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F1%2F65%3Frss%3D1 This report presents a case of renal juxtaglomerular cell tumor in a 63-year-old man with previously unreported histological findings in addition to classic morphology. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4421015 Mon, 31 Jan 2011 00:00:00 +0100 4421015 http://www.medworm.com/index.php?rid=4421014&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Freprint%2F19%2F1%2F64%3Frss%3D1 (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4421014 Mon, 31 Jan 2011 00:00:00 +0100 4421014 http://www.medworm.com/index.php?rid=4421013&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Freprint%2F19%2F1%2F63%3Frss%3D1 (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4421013 Mon, 31 Jan 2011 00:00:00 +0100 4421013 http://www.medworm.com/index.php?rid=4421012&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Freprint%2F19%2F1%2F62%3Frss%3D1 (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4421012 Mon, 31 Jan 2011 00:00:00 +0100 4421012 http://www.medworm.com/index.php?rid=4421011&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F1%2F51%3Frss%3D1 Conclusions: The majority of nasopharyngeal T- and NK-cell lymphomas are NKTCL in Guangzhou district. The patients often have involvement of cervical lymph node(s) and an elevated level of serum anti-EBV antibodies. The CD56 expression rate seems lower than that found in sinonasal NKTCL. The most common EBV variant harboring in nasopharyngeal NKTCL seems somewhat different from that harboring in nasopharyngeal carcinoma in Guangzhou. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4421011 Mon, 31 Jan 2011 00:00:00 +0100 4421011 http://www.medworm.com/index.php?rid=4421010&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F1%2F44%3Frss%3D1 Lymphomas involving the central nervous system are recognized increasingly in immunocompetent as well as immunosuppressed individuals, and the majority of the cases are diffuse large B-cell lymphoma (DLBCL). The aim of this study was to compare the immunophenotype, clinicopathological features, and association with Epstein-Barr virus (EBV) of DLBCL of the central nervous system (CNS) in 3 different clinical situations: primary, in immunocompetent patients; "primary," in immunosuppressed patients; and in patients with secondary involvement by systemic lymphoma. The authors reviewed the clinicopathological features, morphology, immunophenotype (according to germinal-center B-cell—like and nongerminal B-cell—like subtypes), and association with EBV in 36 cases of DLBCL of the CNS,... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4421010 Mon, 31 Jan 2011 00:00:00 +0100 4421010 http://www.medworm.com/index.php?rid=4421009&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F1%2F35%3Frss%3D1 The authors analyzed 52 cases of female breast angiolipoma (AL). Age distribution was 25 to 80 years of age (56.81 ± 12.78). Most cases showed vascularity below 50%, and 14 cases had vascularity >50%. Cellular and low-vascularity ALs had different clinical and radiological presentations. The mean size was 7.00 ± 3.62 mm for cellular ALs and 19.61 ± 7.58 mm for low-vascularity ALs. In any paucicellular area, the authors could identify a cluster of at least 3 interconnected vessels. The endothelium was mostly flat with uniform, hyperchromatic nuclei, and mitoses and nucleoli were absent. Fibrin thrombi in proliferating capillaries were noted in 96% of cases. Low-vascularity AL can be reliably distinguished on needle core biopsy from other lipomatous and vascular tumor... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4421009 Mon, 31 Jan 2011 00:00:00 +0100 4421009 http://www.medworm.com/index.php?rid=4421008&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F1%2F31%3Frss%3D1 In this study, 32 cases of ESCC were examined to determine the relationship between p16INK4 expression and high-risk HPV. All the tumors were stained by immunohistochemistry for p16INK4. Tumors having p16INK4 nuclear and/or nuclear and cytoplasmic expression were considered positive. Tumors positive for p16INK4 expression were tested for high-risk HPV by in situ hybridization (ISH). In all, 20 cases of ESCC (63%) showed only cytoplasmic staining for p16INK4, and 11 cases (34%) showed both cytoplasmic and nuclear staining for p16INK4; 4 cases (13%) showed no staining for p16INK4. None of the p16INK4 -positive cases were positive for high-risk HPV by ISH. These results indicate that p16INK4 expression in ESCC does not correlate with the presence of high-risk HPV DNA by ISH. High-risk HPV doe... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4421008 Mon, 31 Jan 2011 00:00:00 +0100 4421008 http://www.medworm.com/index.php?rid=4421007&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F1%2F26%3Frss%3D1 The DNA-binding factor TFE3 is closely related to microphthalmia-associated transcription factor (MiTF) and is over-expressed in alveolar soft part sarcoma (ASPS) and select renal cell carcinomas. Reports of TFE3 expression in PEComa prompted investigation into TFE3 expression among other members of the putative MiTF group of neoplasms. The authors examined cases of PEComa (n = 6), conventional angiomyolipoma (AML; n = 22), metastatic melanoma (n = 16), and clear cell sarcoma (CCS; n = 9) for TFE3 expression. Nuclear immunostaining was observed in 74% (39/53) of cases, as follows: 5/6 PEComas, 18/22 AMLs, 10/16 metastatic melanomas, and 6/9 CCSs. However, with the exception of PEComas, compared with ASPS controls, TFE3 staining was significantly less intense in the tumors examined. These r... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4421007 Mon, 31 Jan 2011 00:00:00 +0100 4421007 http://www.medworm.com/index.php?rid=4421006&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F1%2F20%3Frss%3D1 In this study, the EGFR/CEP7 gene copy number in 17 MBCs with chondroid, squamous, and spindle-cell differentiation showing EGFR expression by immunohistochemistry was analyzed using fluorescence in situ hybridization. All cases had a balanced EGFR/CEP7 ratio. EGFR gene amplification was not observed in any case. Monosomy was found in 25% and polysomy in 12.5% of carcinomas with chondroid differentiation. All spindle-cell carcinomas and 50% of squamous carcinomas showed trisomy. Comparison with CEP7 copy number revealed aneusomy of chromosome 7, as opposed to increases or decreases specific to the EGFR gene or 7p. Although no direct correlation between EGFR expression by immunohistochemistry and aneusomy was observed, cases with a score of 3+ showed a higher frequency of EGFR gene copy gai... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4421006 Mon, 31 Jan 2011 00:00:00 +0100 4421006 http://www.medworm.com/index.php?rid=4421005&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F1%2F11%3Frss%3D1 Nest-like structures are the cardinal lesion of different benign and malignant bladder entities. These entities emphasize the biological relevance of the subtle morphological nest plasticity. The authors present 25 benign and malignant neoplasms, sharing the presence of florid nest-like growth and the scarcity or absence of superficial papillary components. Differential diagnostic clues are discussed. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4421005 Mon, 31 Jan 2011 00:00:00 +0100 4421005 http://www.medworm.com/index.php?rid=4421004&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F19%2F1%2F5%3Frss%3D1 The aims of this paper were to review the literature of Spermatocytic Seminoma (SS) updating its clinico-pathological features and to present a new case of the exceptionally rare variant of this tumor known as anaplastic which only five cases have been reported. Many studies have confirmed that SS is a distinct neoplasm both clinically and pathologically from classical Seminoma and it differs from the latter especially in regard to behavior, characterized by an almost complete inability to metastasize with only very few convincing examples described with metastatic behavior. There is general agreement that orchidectomy is sufficient therapy for SS and that surveillance following surgery is the preferred management option. Surprisingly, the presence of an anaplastic component does not seem ... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4421004 Mon, 31 Jan 2011 00:00:00 +0100 4421004 http://www.medworm.com/index.php?rid=4169871&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F6%2F584%3Frss%3D1 Malakoplakia is an uncommon chronic inflammatory disorder, which is characterized by the presence of histiocytes containing concentric concretions known as Michaelis-Gutmann bodies in a background of mixed inflammation. The urinary tract is the most commonly involved site. However, malakoplakia can be found in a wide range of other organs throughout the body. Its occurrence has been attributed to a defect in the bactericidal capacity of phagocytic cells, and it is usually seen in patients with some degree of immunologic compromise. A case of malakoplakia of the spleen in a patient with Crohn’s disease is reported in this article. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4169871 Mon, 15 Nov 2010 00:00:00 +0100 4169871 http://www.medworm.com/index.php?rid=4169870&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F6%2F580%3Frss%3D1 We present the case of a 72-year-old woman with low back pain and a well-demarcated lytic lesion of the sacrum, which at histological and ultrastructural examination was indistinguishable from central nervous system CHB. The patient had no signs of VHL disease and died of another cause with no evidence of disease 57 months after curettage of the lesion. To our knowledge, this is the second case of CHB reported to occur in bone. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4169870 Mon, 15 Nov 2010 00:00:00 +0100 4169870 http://www.medworm.com/index.php?rid=4169869&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F6%2F575%3Frss%3D1 This study describes the case of a 62-year-old man who displayed a gradually growing retroareolar tumor of the left breast. The mass was well circumscribed, unilateral, and grossly nodular. The patient eventually underwent wide local excision of the mass. The lesion was made up of spindle cells arranged in fascicular clusters, separated by bands of collagen. No mitotic figures were observed. Immunohistochemically, the mass expressed strong and diffuse cytoplasmic staining for vimentin, CD34, CD10, and bcl-2, whereas it was negative for cytokeratins, smooth muscle actin, desmin, S-100 protein, p53, Ki-67, estrogen and progesterone receptors. Diverse histological results and immunohistochemical features established the diagnosis of benign BSCT, not otherwise specified. The patient remains di... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4169869 Mon, 15 Nov 2010 00:00:00 +0100 4169869 http://www.medworm.com/index.php?rid=4169868&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F6%2F570%3Frss%3D1 The development of squamous metaplasia or carcinoma is a rare occurrence in the setting of a ruptured or leaking silicone breast implant capsule. However, the oncogenic process in such a context is yet another intriguing example of how chronic inflammation plays an integral role in the tumorigenic process. Recent papers have shed light on how inflammation involving M2-tpe macrophages, lymphocytes, and other inflammatory cells at first provide the cytokines necessary to fend off an inciting foreign-body attack such as silicone from a ruptured or leaking implant. Although such a response is beneficial in keeping infection or foreign material in check, there are instances when the response may be exaggerated. It is thought that the extent and length of the response, the balance between pro-in... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4169868 Mon, 15 Nov 2010 00:00:00 +0100 4169868 http://www.medworm.com/index.php?rid=4169867&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F6%2F564%3Frss%3D1 We describe a case of PASH with foci of malignant histologic features presenting as a slowly growing mass in a 30-year-old woman. The previously reported variants of PASH and the other mammary stromal lesions related to PASH are also discussed. This is perhaps the first case of PASH with foci of malignant histologic features reported in the literature and represents a rare sarcoma derived from specialized hormonally responsive mammary stroma. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4169867 Mon, 15 Nov 2010 00:00:00 +0100 4169867 http://www.medworm.com/index.php?rid=4169866&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F6%2F561%3Frss%3D1 We report a mature solid teratoma of the fallopian tube in an elderly woman. This mass was noted on CT scan and considered metastatic in nature since following a bioptical diagnosis of endometrial adenocarcinoma. Hysterectomy and bilateral salpingectomy and ovariectomy were performed and a second minor mature solid teratoma was discovered inside the right ovary. Neoplasms of the fallopian tube are very uncommon and this is the first Italian case to be added to about other 60 of the literature. Moreover it joins minimum teratomatous diameter with maximum recorded age. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4169866 Mon, 15 Nov 2010 00:00:00 +0100 4169866 http://www.medworm.com/index.php?rid=4169865&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F6%2F557%3Frss%3D1 A 55-year-old woman underwent a total hysterectomy, bilateral salpingo-oophorectomy, partial omentectomy, and lymphadenectomy for endometrial cancer. Histologically, the cancer was endometrioid adenocarcinoma grade 1, which invaded the myometrium. There was no macroscopically detectable mass in the ovaries. However, histological examination revealed a small tumor, 1 mm in size, in the medulla of the right ovary. The ovarian tumor was composed of uniform epithelioid cells that grew in nests. Vessels of various sizes were observed within the tumor, and they were surrounded by tumor cells. Immunohistochemically, the ovarian tumor was positive for smooth muscle actin and vimentin but negative for desmin and CD34. Based on these findings, the authors made the diagnosis of ovarian glomus tumor. ... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4169865 Mon, 15 Nov 2010 00:00:00 +0100 4169865 http://www.medworm.com/index.php?rid=4169864&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F6%2F554%3Frss%3D1 Endobronchial metastasis from a prostate cancer is uncommon. Diagnosis of prostate carcinoma after primary presentation with an endobronchial mass is very rare. The authors describe the case of an 84-year-old man with endobronchial metastases from prostatic carcinoma presenting primarily with pulmonary symptoms. The diagnosis of prostate cancer and endobronchial metastases was made by a bronchoscopic bronchial biopsy and confirmed by immunohistological staining with prostate-specific antigen. The importance of this manifestation along with clinical and therapeutic implications is discussed here. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4169864 Mon, 15 Nov 2010 00:00:00 +0100 4169864 http://www.medworm.com/index.php?rid=4169863&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F6%2F550%3Frss%3D1 In this report, an 87-year-old White man with the Lynch syndrome had a prostate biopsy that revealed a mixed high-grade conventional adenocarcinoma and SCC of the prostate with high-grade prostatic intraepithelial neoplasia of the small cell neuroendocrine-type (HGPIN-NE), all showing MSH2 microsatellite instability and loss of MSH2 expression, a finding not previously published. These findings suggest that HGPIN-NE is a precursor of invasive SCC and also that prostatic SCC can develop in a patient with the Lynch syndrome. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4169863 Mon, 15 Nov 2010 00:00:00 +0100 4169863 http://www.medworm.com/index.php?rid=4169862&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F6%2F547%3Frss%3D1 This study presents a "typical" case with light, cytochemical, immunohistochemical, and ultrastructural characterization. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4169862 Mon, 15 Nov 2010 00:00:00 +0100 4169862 http://www.medworm.com/index.php?rid=4169861&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F6%2F544%3Frss%3D1 Extramedullary hematopoiesis (EMH) is a phenomenon in which benign immature hematopoietic cells are found in sites other than the bone marrow. Although usually associated with an underlying hematologic abnormality such as myelofibrosis, it can be found in some physiologic states or occasionally within solid tumors. In most instances, foci of EMH contain elements of all cell lineages. Presented here is the second reported case of EMH occurring in a low-grade clear cell renal cell carcinoma in a patient without evidence of hematologic disease. As previously, it manifested as pure erythropoiesis as confirmed by morphology and immunohistochemistry. It is possible that this finding is related to erythropoietin secretion by the tumor and not hematologic malignancy. (Source: International Journal... International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4169861 Mon, 15 Nov 2010 00:00:00 +0100 4169861 http://www.medworm.com/index.php?rid=4169860&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F6%2F540%3Frss%3D1 This study reports a case of RDD apparently limited to the liver coexisting with a diffuse (stage IV) relapsing follicular lymphoma. The patient is alive and well 24 months after the diagnosis of the lymphoma. It is conceivable that the lymphoma has induced RDD via an immunological disorder, possibly involving interleukin expression. The favorable outcome supports the belief that the prognosis of RDD is largely dependent on the number of extranodal sites involved, rather than on the specific sites themselves. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4169860 Mon, 15 Nov 2010 00:00:00 +0100 4169860 http://www.medworm.com/index.php?rid=4169859&cid=s_28428_32_f&fid=28428&url=http%3A%2F%2Fijs.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F6%2F537%3Frss%3D1 We report a case of hepatic angiomyolipoma associated to a small bowel schwannoma in a 40-years old woman. Both lesions were asyntomatic. Histologically, hepatic angiomyolipoma showed oncocytic features and scanty adipose tissue, the tumor cells expressed desmin, smooth muscle actin, S-100 protein and HMB45. The tumor cells of intramural small intestinal mass were positive for S-100 protein and GFAP and negative for CD117, CD34 and desmin. To the best of our knowledge, no case of hepatic angiomyolipoma has been previously reported in association with intestinal schwannoma. (Source: International Journal of Surgical Pathology) International Journal of Surgical Pathology journals http://www.medworm.com/rss/comments.php?id=4169859 Mon, 15 Nov 2010 00:00:00 +0100 4169859