MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'International Wound Journal' source. Fri, 03 Feb 2012 06:33:50 +0100 http://www.medworm.com/index.php?rid=5653865&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00925.x This is the second part of the article based on the thesis work for a Masters of Science in Wound Healing and Tissue Repair, Cardiff University, to develop an evidence‐based protocol for the care of pilonidal sinus wounds (PSWs) healing by secondary intent, using a modified Reactive Delphi process. The sample included surgeons, clinic physicians, nurses and enterostomal therapy nurses experienced in the care of these wounds. Item generation involved an extensive review of the literature to identify key aspects of evidence‐based wound care essential to wound healing, infected wounds and pilonidal wounds healing by secondary intent and drawing on clinical experience. The participants responded via an electronic Delphi website, using a 4‐point Likert rating scale and a ranking system. C... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5653865 Thu, 02 Feb 2012 05:00:00 +0100 5653865 http://www.medworm.com/index.php?rid=5653868&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00921.x In conclusion, we found that patients treated with ultrasound therapy and compression therapy show clinical improvement over the course of 4 weeks and had a decrease in inflammatory cytokines, bacterial counts and pain. (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5653868 Wed, 01 Feb 2012 05:00:00 +0100 5653868 http://www.medworm.com/index.php?rid=5653867&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00933.x This study evaluated the wound‐healing and antimicrobial activity of C. papaya seed extract. Ethanol extract of C. papaya seed (50 mg/kg/day) was evaluated for its wound‐healing activity in Sprague‐Dawley rats using excision wound model. Animals were randomly divided into four groups of six each (group 1 served as control, group 2 treated with papaya seed extract, group 3 treated with a standard drug mupirocin and papaya seed extract (1:1 ratio) and group 4 treated with a mupirocin ointment. Rate of wound contraction and hydroxyproline content were determined to assess the wound‐healing activity of the seed extract. The group 2 animals showed a significant decrease in wound area of 89% over 13 days when compared with groups 1 (82%), 3 (86%) and 4 (84%) respectively. The hydroxyprol... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5653867 Wed, 01 Feb 2012 05:00:00 +0100 5653867 http://www.medworm.com/index.php?rid=5653866&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00937.x In Tanzania, limited laboratory services often preclude routine identification of microorganisms that cause infections in persons with diabetes. Thus, we carried out this study to determine the utility of a Gram stain alone versus culture in guiding appropriate antimicrobial therapy. During February 2006 to December 2007 (study period), deep tissue biopsies were obtained from persons with diabetes presenting to the Muhimbili National Hospital (MNH) with infected limb ulcers. Specimens were Gram‐stained then cultured for bacteria and fungi. Biopsies were obtained from 128 patients. Of 128 cultures, 118 (92%) yielded bacterial or fungal growth; 59 (50%) of these 118 cultures yielded mixed growth (80% included Gram‐negative organisms); 38 (32%) and 20 (17%) yielded Gram‐negative and Gra... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5653866 Wed, 01 Feb 2012 05:00:00 +0100 5653866 http://www.medworm.com/index.php?rid=5653864&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2012.00939.x A prospective case series was studied to assess the potential for complete healing of wounds among patients with advanced illness referred to a regional palliative care program in Toronto, Canada. Two hundred and eighty‐two patients, of which 148 were primarily diagnosed with cancer and 134 with non cancer advanced illness, were assessed and followed until their deaths. On the baseline initial referral date, 823 wounds were documented. The wound classes assessed included pressure ulcers, malignant wounds, skin tears, venous leg ulcers, diabetic foot ulcers and arterial leg/foot ulcers. Proportions of patients showing complete healing of at least one wound were calculated, stratified by patient's survival time post‐baseline (1 week, 1 month, 3 months and 6 months). Proportions of patien... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5653864 Wed, 01 Feb 2012 05:00:00 +0100 5653864 http://www.medworm.com/index.php?rid=5653870&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2012.00938.x Stenotrophomonas maltophilia is a recently described organism which was mainly reported either in nosocomial setup, or in immunosuppresed individuals. This was rarely reported as cutaneous pathogenic organism causing cellulitis‐like lesion, paronychia, mucocutaneous ulcers and ecthyma gangrenosum in immunocompromised individuals. Here we describe a case of leg ulcer caused by S. maltophilia in an immuno‐competent patient. The infection was possibly community acquired as the patient had no exposure to hospital environment. The bacillus was sensitive to cotrimoxazole and levofloxacin, and the patient was successfully treated with cotrimoxazole. Our case is unique not only because it is probably the first ever case of leg ulcer caused by S. maltophilia, but also because of its unusual occ... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5653870 Tue, 31 Jan 2012 05:00:00 +0100 5653870 http://www.medworm.com/index.php?rid=5653869&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2012.00944.x The purpose of this study was to assess the effectiveness of non contact low‐frequency ultrasound on the healing of suspected deep tissue injury (SDTI). Participants were adults ranging in age from 28 to 93 years old, with multiple diagnoses including anaemia, diabetes mellitus and hypertension. Data were examined retrospectively on 85 patients (intervention group = 43 and non intervention group = 42) with 127 SDTI (intervention group = 64 and non intervention group = 63). Participants in both groups received standard of care for treating pressure ulcers. A severity score was used to assess SDTI severity before treatment and healing/progression after treatment. This scale measures surface area, wound colour/tissue assessment, and skin integrity with potential scores of 3 to 18 (higher sc... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5653869 Tue, 31 Jan 2012 05:00:00 +0100 5653869 http://www.medworm.com/index.php?rid=5641578&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00935.x Pressure mapping alone insufficiently describes tissue health. Comprehensive, quantitative non invasive assessment is crucial. Interface pressures (IPs) and transcutaneous blood gas levels [transcutaneous tissue oxygen (TcPO2)] were simultaneously assessed over both ischia and the sacrum to investigate the hypotheses: (i) tissue oxygenation decreases with sustained applied pressure; (ii) tissue oxygen and IP are inversely correlated in loaded soft tissues; (iii) multisite assessments are unnecessary because healthy individuals are symmetrical. Measurements were taken at 5‐minute intervals for 20 minutes in both sitting and supine lying for a cohort of 20 able‐bodied adults. There were no statistically significant changes over time for either variable in 96% of timepoint comparisons. Sp... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5641578 Mon, 30 Jan 2012 14:11:02 +0100 5641578 http://www.medworm.com/index.php?rid=5614353&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00914.x A prospective study was carried out to assess the role of citric acid as a sole antimicrobial agent in the management of lepromatous ulcers. Thirty‐four known cases of lepromatous ulcers not responding to conventional antibiotic therapies for long duration were investigated for culture and susceptibility studies. Staphylococcus aureus (25·00%) and Klebsiella spp. (23·43%) were found to be the most common isolates. Amikacin (68·75%) and ciprofloxacin (67·18%) were found to be the most effective antimicrobial agents. Topical application of citric acid ointment resulted in complete healing in 25 (73·52%) cases. In eight cases (26·48%), there was elimination of infective agent from ulcer site and formation of healthy granulation, but no complete healing of ulcer was seen. Results indic... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5614353 Sat, 21 Jan 2012 10:46:19 +0100 5614353 http://www.medworm.com/index.php?rid=5614354&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00911.x In this study, we evaluated pain intensity during the removal of wound dressing materials in healthy volunteers by comparing pain during the removal of wound dressing materials, which use acrylic pressure‐sensitive adhesive and pain during the removal of materials, which use soft silicone adhesive, as evaluated using the PainVision™ system. Pain intensity was significantly lower with the dressing materials, which use soft silicone adhesive when measured with the PainVision™ system. The PainVision™ system promises to be useful for the quantitative assessment of pain caused by the removal of adhesive wound dressing materials. Further studies are needed to determine whether the PainVision™ system is also effective in measuring pain caused by the removal of wound dressing materials i... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5614354 Fri, 20 Jan 2012 05:00:00 +0100 5614354 http://www.medworm.com/index.php?rid=5601864&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00926.x For several wound products compelling evidence is available on their effectiveness, for example, from systematic reviews. The process of buying, prescribing and applying wound materials involve many stakeholders, who may not be aware of this evidence, although this is essential for uniform and optimum treatment choice. In this survey, we determined the general awareness and use of evidence, based on (Cochrane) systematic reviews, for wound products in open wounds and burns among wound care stakeholders, including doctors, nurses, buyers, pharmacologists and manufacturers. We included 262 stakeholders. Doctors preferred conventional antiseptics (e.g. iodine), while specialised nurses and manufacturers favoured popular products (e.g. silver). Most stakeholders considered silver‐containing ... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5601864 Wed, 18 Jan 2012 11:56:27 +0100 5601864 http://www.medworm.com/index.php?rid=5601867&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00919.x Over the last decade, maggot debridement therapy (MDT) has been recognized by many clinicians as a potential adjunct to conventional therapy, and many patients with non healing, chronic ulcers have been treated. Numerous case reports and case series have described the successful use of MDT in a variety of ulcers. However, comparative clinical trials and in particular randomized controlled trials investigating the efficacy of MDT are sparse.A systematic search in the literature showed three randomized clinical trials and five non randomized studies evaluating the efficacy of sterile Lucilia sericata applied on ulcers with various aetiologies. Of these, seven studies had debridement and/or healing as an outcome variable.When evaluating maggots as debriding agents, the studies report MDT as b... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5601867 Tue, 17 Jan 2012 05:00:00 +0100 5601867 http://www.medworm.com/index.php?rid=5601866&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00923.x Wound management has progressed significantly over the last five decades. This emanates from a greater understanding of wound healing, technological progression and improved clinical and scientific research. There are currently a plethora of absorbent dressings on the wound care market which claim to have the ability to manage exudates whilst encouraging healing. However, it is becoming clear, from analysing randomised controlled trials, that some of these absorbent dressings are not meeting their expectations when applied in a clinical setting. Many clinicians now feel that there should be more focus, not only on a dressing's ability to manage exudate efficiently, but on a dressing's ability to proactively encourage healing and thus exudate reduction will ensue. This paper proposes to cri... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5601866 Tue, 17 Jan 2012 05:00:00 +0100 5601866 http://www.medworm.com/index.php?rid=5601865&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00932.x There is still no objective method or reliable device to measure and assess the physical properties of keloid and hypertrophic scars. Using the Vesmeter, we measured the physical properties of keloid and hypertrophic scars, and investigated how their physical properties changed during the process of clinical follow‐up. We followed up 11 patients with keloid (n = 6) and hypertrophic (n = 5) scars for 4 months, and measured their physical properties three times over a 2‐month period using the Vesmeter. Measurements included hardness, elasticity, penetration depth, relaxation time, viscosity and viscoelastic ratio. All physical properties were measured simultaneously while an indenter was pressed onto the lesion and digitalise the measured data by analysing the wave forms of the lesion's ... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5601865 Tue, 17 Jan 2012 05:00:00 +0100 5601865 http://www.medworm.com/index.php?rid=5588712&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00924.x Annona squamosa L. (Annonaceae), commonly known as custard apple, mainly used for its edible fruit, is also recognised with numerous medicinal properties. As there is no report on the efficacy of this plant for wound healing, we examined the efficacy of ethanolic extract of A. squamosa leaves on wound repair in streptozotocin–nicotinamide‐induced diabetic rats. Open excision wounds were made on the back of rats. The drug at a dosage of 100 mg/kg body wt was reconstituted in 200 µl of phosphate buffered saline and applied topically once daily for the treated wounds. The control wounds were left untreated. Wound tissues formed on days 4, 8, 12 and 16 (post‐wound) were used to estimate DNA, total protein, total collagen, hexosamine and uronic acid. Levels of lipid peroxides were also e... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5588712 Sat, 14 Jan 2012 22:18:40 +0100 5588712 http://www.medworm.com/index.php?rid=5588713&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00920.x This article presents the beneficial results of treatment of a 67‐year‐old woman patient with a diagnosis of crural vein ulceration in the right limb. The applied physiotherapeutic method, in the form of magnetostimulation, contributed to complete healing of the lesion, subsidence of symptoms, as well as improved life quality of the treated patient. (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5588713 Wed, 11 Jan 2012 05:00:00 +0100 5588713 http://www.medworm.com/index.php?rid=5588714&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00918.x In conclusion, it is not possible to confirm that there are any differences between the studied and the placebo treatments in the prevention of PUs. The results obtained were similar to those obtained in studies of PU prevention using products based on topical fatty acids. (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5588714 Tue, 10 Jan 2012 05:00:00 +0100 5588714 http://www.medworm.com/index.php?rid=5574887&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00931.x (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5574887 Mon, 09 Jan 2012 10:53:31 +0100 5574887 http://www.medworm.com/index.php?rid=5574886&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00929.x (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5574886 Mon, 09 Jan 2012 10:53:10 +0100 5574886 http://www.medworm.com/index.php?rid=5574885&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00928.x (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5574885 Mon, 09 Jan 2012 10:53:09 +0100 5574885 http://www.medworm.com/index.php?rid=5574884&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00930.x (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5574884 Mon, 09 Jan 2012 10:53:07 +0100 5574884 http://www.medworm.com/index.php?rid=5564920&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00889.x This study may provide an effective, safe and less costly alternative for treating chronic wounds. (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5564920 Fri, 06 Jan 2012 05:00:00 +0100 5564920 http://www.medworm.com/index.php?rid=5564919&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00915.x (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5564919 Fri, 06 Jan 2012 05:00:00 +0100 5564919 http://www.medworm.com/index.php?rid=5564921&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00917.x (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5564921 Thu, 05 Jan 2012 05:00:00 +0100 5564921 http://www.medworm.com/index.php?rid=5530248&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00902.x Antibiotics are routinely used in woundcare for the treatment of local and systemic infections. Our goals in this paper were to (i) evaluate the antibiotic sensitivity of bacteria isolated from burn and chronic wounds and (ii) evaluate the effect of pH and bacterial phenotype on the efficacy of antibiotics. Chronic and burn wound isolates, which had been routinely isolated from patients at West Virginia University Hospital, USA, were evaluated for their sensitivity to antibiotics. Antimicrobial susceptibility testing was performed using a standardised disk diffusion assay on agar (quasi/non biofilm) and poloxamer (biofilm). Many of the Gram‐positive and ‐negative isolates demonstrated changes in susceptibility to antibiotics when grown at different pH values and phenotypic states. Find... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5530248 Mon, 19 Dec 2011 05:00:00 +0100 5530248 http://www.medworm.com/index.php?rid=5530247&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00903.x The antibiotic‐resistant bacteria are a major concern to wound care because of their ability to resist many of the antibiotics used today to treat infections. Consequently, other antimicrobials, in particular ionic silver, are considered ideal topical agents for effectively helping to manage and prevent local infections. Little is known about the antimicrobial efficacy of ionic silver on antibiotic‐resistant bacteria at different pH values. Consequently, in this study our aim was to evaluate the effect of pH on the antimicrobial efficacy of a silver alginate (SA) and a silver carboxymethyl cellulose (SCMC) dressing on antibiotic‐resistant bacteria isolated from burn patients. Forty‐nine antibiotic‐resistant bacteria, including Vancomycin‐resistant Enterococcus faecium, meticill... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5530247 Mon, 19 Dec 2011 05:00:00 +0100 5530247 http://www.medworm.com/index.php?rid=5530246&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00904.x The enamel matrix derivative (EMD) is a preparation of the enamel matrix proteins secreted by the Hertwig's epithelial root sheath. It has been shown that EMD promotes periodontal wound healing; however, the significance of the protein in repairing skin wounds is insufficiently addressed. The aim of this in vivo histomorphometric investigation was to analyse the effect of EMD protein on the healing of standardised epithelial wounds. Dorsal skin of 22‐week‐old female guinea pigs (n = 33) was scarified and divided into test‐ (topical application of EMD) and control‐sites (sutured and allowed to heal). Animals were euthanised at specific time intervals and the specimens were then evaluated histomorphometrically. The mean widths of the external wound gaps (WGs) in the test‐ and contr... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5530246 Mon, 19 Dec 2011 05:00:00 +0100 5530246 http://www.medworm.com/index.php?rid=5530245&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00905.x Amino‐bisphosphonates (N‐BPs) are widely used to treat a great variety of clinical conditions involving altered calcium metabolism, as well as to prevent bone metastases. The use of N‐BPs, however, display well‐known side effects, including cellular toxicity, mainly at soft tissue and mucosal level, that arise from N‐BPs ability to induce cell apoptosis when administered at clinically relevant concentrations. The aim of this study was to evaluate, in an in vitro wound healing model, the effect of N‐BPs low concentration (10 nM–10 µM) stimulation on keratinocyte cellular behaviour. Human keratinocytes were treated with neridronate and zoledronate, two N‐BPs with different chemical structure and clinical potency, but sharing a common pharmacological target: farnesyl pyrophos... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5530245 Mon, 19 Dec 2011 05:00:00 +0100 5530245 http://www.medworm.com/index.php?rid=5509507&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00898.x Use of silicone derivative and onion extract had been reported in the prevention of hypertrophic scarring. Our experience showed the preventive use of silicone derivative plus onion extract gel on hypertrophic scars after median sternotomy. In a randomized, double blinded, placebo‐controlled study, 60 patients after median sternotomy incisions were separated into two groups. All patients were treated either with silicone derivative plus onion extract gel (Cybele® scagel) or placebo gel twice daily for a total treatment period of 12 weeks. During each visit, pain and itching scores were graded by the patients and scar characteristics were observed by surgeons using the Vancouver scar scale. Pain and itch score values from patients' who applied silicone derivative plus onion extract gel w... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5509507 Wed, 14 Dec 2011 05:00:00 +0100 5509507 http://www.medworm.com/index.php?rid=5509506&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00909.x In this study, granulation tissue appeared significantly lesser in wounds of group 3 animals followed by group 2 and 1 animals. Neovascularisation, granulation tissue formation, denser, thicker and better arranged collagen fibres, reticulin fibres and elastin fibres formation was more in group 1 as compared with other groups. It was concluded that the application of bone marrow‐derived nucleated cells into the wound margins resulted in early and significantly faster rate of complete healing as compared with buffy coat of autologous blood and autologous plasma (control). This approach may be beneficial in various surface wounds that heal at a slower rate and recommended for healing of various complicated wound in future. (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5509506 Wed, 14 Dec 2011 05:00:00 +0100 5509506 http://www.medworm.com/index.php?rid=5509505&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00906.x (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5509505 Wed, 14 Dec 2011 05:00:00 +0100 5509505 http://www.medworm.com/index.php?rid=5509504&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00894.x (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5509504 Wed, 14 Dec 2011 05:00:00 +0100 5509504 http://www.medworm.com/index.php?rid=5509503&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00899.x Chronic leg ulcers are a significant cause of morbidity and mortality and account for considerable healthcare and socioeconomic costs. Leg ulcers are a recognised complication of immune disease, and the purpose of this study was to establish the prevalence of immune disease in a cohort of patients with chronic wounds, and to compare wound outcomes in the subjects with and without immune disease.Retrospective chart review was completed on consecutive patients scheduled with the plastic surgeon in the Georgetown University Center for Wound Healing between 1 January 2009 and 31 March 2009. Of the 520 patients scheduled for appointments, 340 were eligible for inclusion. The prevalence of immune disease was higher than expected with 78 of 340 patients (23%) having associated immune disease. At ... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5509503 Wed, 14 Dec 2011 05:00:00 +0100 5509503 http://www.medworm.com/index.php?rid=5509502&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00907.x (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5509502 Wed, 14 Dec 2011 05:00:00 +0100 5509502 http://www.medworm.com/index.php?rid=5490683&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00880.x This article describes the collaborative process undertaken by the Canadian Association for Enterostomal Therapy and the Canadian Association of Wound Care in an effort to improve the quality of wound prevention and management education and programming. The end result of this process is the Wound CARE Instrument which promotes an interprofessional, collaborative appraisal process to support the development, adoption or adaption of wound management educational events and programs. (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5490683 Thu, 08 Dec 2011 05:00:00 +0100 5490683 http://www.medworm.com/index.php?rid=5564918&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00916.x (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5564918 Thu, 01 Dec 2011 05:00:00 +0100 5564918 http://www.medworm.com/index.php?rid=5530244&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00910.x Chronic wounds, including diabetic foot ulcers, pressure ulcers and venous leg ulcers, represent a significant cause of morbidity in developed countries, predominantly in older patients. The aetiology of these wounds is probably multifactorial, but the role of bacteria in their pathogenesis is still unclear. Moreover, the presence of bacterial biofilms has been considered an important factor responsible for wounds chronicity. We aimed to investigate the laser action as a possible biofilm eradicating strategy, in order to attempt an additional treatment to antibiotic therapy to improve wound healing. In this work, the effect of near‐infrared (NIR) laser was evaluated on mono and polymicrobial biofilms produced by two pathogenic bacterial strains, Staphylococcus aureus PECHA10 and Pseudomo... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5530244 Thu, 01 Dec 2011 05:00:00 +0100 5530244 http://www.medworm.com/index.php?rid=5509500&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00908.x A study conducted in an Australian home nursing service sought to ascertain whether the provision of funding for compression bandaging and medical footwear would impact on compression therapy use, wound healing and quality of life (QoL) among people with venous leg ulcers. Clients (n = 120) were randomly allocated to evaluation funded or not evaluation funded groups, the former provided funding for compression bandaging and medical footwear. Outcome measures included the number of wounds healed, healing rate, compression use and QoL. Analysis included ttests and Kaplan–Meier Survival Analysis. An alpha level of 0·05 classified findings as significant. There were no significant differences between groups for rate or time to healing, wounds healed or compression use. The evaluation funded... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5509500 Thu, 01 Dec 2011 05:00:00 +0100 5509500 http://www.medworm.com/index.php?rid=5499285&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00901.x Chronic painful wounds, a major health problem, have a detrimental impact on the quality of life due to associated pain. Some clinical reports have suggested that local administration of morphine could be beneficial. The aim of this study was to evaluate the analgesic effect of topically applied morphine on chronic painful leg ulcers. Twenty‐one patients were randomly assigned to receive either morphine or placebo in a randomised, placebo‐controlled, crossover pilot study. Each patient was treated four times in total. Pain was measured by the visual analogue score (VAS) before application of gel, directly after and after 2, 6, 12 and 24 hours. Although an overall, clinically relevant, reduction of pain was observed upon treatment with morphine, the difference was not statistically sign... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5499285 Thu, 01 Dec 2011 05:00:00 +0100 5499285 http://www.medworm.com/index.php?rid=5490682&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00896.x This study provides a broad update on our knowledge of the risk factors for DSWI and the scales for prediction with a view to improving the management of infections at cardiosurgery units. (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5490682 Thu, 01 Dec 2011 05:00:00 +0100 5490682 http://www.medworm.com/index.php?rid=5480957&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00879.x In this study, permeations of clindamycin phosphate (CP, hydrophilic) and diazepam (lipophilic) through human burn eschar were investigated in the presence and absence of ethanol. Permeability coefficients (Kp) of CP and diazepam through hydrated eschar were calculated to be 13·1 × 10−3 and 17·4 × 10−3 cm/h respectively. These Kp values were decreased by about 1·5–5·3 and 2–10·7 times respectively upon the addition of 20–70% ethanol. Increased amount of ethanol decreased permeation flux of CP (2–20 times) and increased that of diazepam (3–80 times) from saturated solutions. Thermal analysis showed that ethanol dehydrates eschar and also changes its internal proteineous structure. Such changes were concluded to be the main reasons behind decreased Kp of both drugs. Comp... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5480957 Thu, 01 Dec 2011 05:00:00 +0100 5480957 http://www.medworm.com/index.php?rid=5462821&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00895.x Cutaneous wound healing is a highly complex process, which includes inflammation, cell proliferation, matrix deposition and remodelling phases. Various growth factors, like epidermal growth factor (EGF), play an important role during wound healing. However, little is known about relationship between EGF and oxidant–antioxidant events in cutaneous wound healing models. Thus we planned to evaluate the connection between EGF therapy and oxidative stress in dermal tissue followed by wounding. Fifty‐four adult male Wistar‐albino rats were randomly divided into three groups: control, untreated and topical EGF administrated group. A linear full‐thickness excision of 40 mm in length on both sides of spinal cord was made on the back of each rat and sutured under anaesthesia and sterile cond... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5462821 Thu, 01 Dec 2011 05:00:00 +0100 5462821 http://www.medworm.com/index.php?rid=5462820&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00900.x This study is designed to evaluate the effectiveness and safety of M. tenuiflora cortex extract (MTC‐2G) in the treatment of VLUs in an Interdisciplinary Wound and Ostomy Care Center (IWOCC). A randomised, placebo‐controlled, double blind clinical trial was conducted to compare the use of a hydrogel containing MTC‐2G with the hydrogel alone in VLUs. The study included all patients with venous ulcers referred to the IWOCC. Laboratory tests and tissue biopsies were performed at the beginning and at the end of the study. The patients were instructed to daily cleansing followed by topical application of the hydrogel and compression. Forty‐one patients were included, 22 patients received the MTC‐2G and 19 patients received the hydrogel only. Of the 41 patients, 32 completed the study,... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5462820 Thu, 01 Dec 2011 05:00:00 +0100 5462820 http://www.medworm.com/index.php?rid=5462819&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00897.x This study investigated the hormonal, oxidative and angiogenic factors affecting wound healing in aged rats. Two groups consisting of eight healthy male Wistar Albino rats [young (30 ± 7 days) and aged (360 ± 30 days)], and a cutaneous incision wound healing model were used. Scar tissue samples from wounds on the 7th, 14th and 21st days of healing were evaluated for hydroxyproline and vascular endothelial growth factor content. Macrophage, lymphocyte, fibroblast and polymorphonuclear cell infiltration; collagen formation and vascularization were assessed by light and electron microscopy. The free oxygen radical content of the wounds was measured by a chemiluminescence method. Blood sample analysis showed that the hydroxyproline and total testosterone levels were significantly higher, and... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5462819 Thu, 01 Dec 2011 05:00:00 +0100 5462819 http://www.medworm.com/index.php?rid=5426159&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00885.x This study is a case report of a meningomyelocele patient with congenital kyphosis who was treated with kyphectomy and a special approach to soft tissue healing. The objective of this study is to show a step by step approach to surgical treatment and postoperative care of a meningomyelocele patient with congenital kyphosis. In meningomyelocele the incidence of kyphosis is around 12–20%. It may cause recurrent skin ulcerations, impaired sitting balance and respiratory compromise. Kyphectomy has first been described by Sharrard. This surgery is prone to complications including pseudoarthrosis, skin healing problems, recurrence of deformity and deep infections. A 15‐year‐old male presented with congenital kyphosis due to meningomyelocele. He had back pain, deformity and bedsores at the ... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5426159 Sat, 19 Nov 2011 23:25:24 +0100 5426159 http://www.medworm.com/index.php?rid=5414315&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00875.x The classification of wounds into healing states depending on their absorption spectrum of visible and near infrared light remains an important task in dermatology. Moreover, a reduction of the spectrum that is used in the classification task to fewer but important wavelengths is desirable, as each measured wavelength increases the examination costs without necessarily providing further information to the classification of wound healing states. This paper addresses two aspects: First the improvement of the classification of wounds into healing states and second, a cost reduction by choosing only important wavelengths. Standard Data Mining methods are evaluated for their classification accuracy (CA) and compared to their performance when applying feature selection techniques that are used t... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5414315 Thu, 17 Nov 2011 13:59:12 +0100 5414315 http://www.medworm.com/index.php?rid=5426161&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00884.x Pre‐tibial lacerations are complex wounds affecting a primarily aged population, with poor healing and a potentially significant impact on social well‐being. Management of these wounds has changed little in 20 years, despite significant advances in wound care. A retrospective observational study was undertaken to observe current wound care practice and to assess the effect of various medical factors on wound healing time on 24 elderly patients throughout their wound journey. Wound length was found to be substantively and significantly associated with wound healing time, with a reduction in instantaneous healing rate of about 30% for every increase of 1 cm in wound length. Hence, longer wounds are associated with longer wound healing times. Prescription of several categories of drugs, i... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5426161 Thu, 17 Nov 2011 05:00:00 +0100 5426161 http://www.medworm.com/index.php?rid=5426160&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00887.x This report shows a successful treatment of a HU‐induced chronic wound associated with squamous cell carcinomas (SCC). A 62‐year‐old patient affected with polycythemia vera and treated with HU for 10 years, presented with a non healing ulcer on a left heel. The patient gave a history of suffering from the wound for over 2 years. Biopsy showed evidence of invasive SCC. The patient underwent Mohs surgery and a greater saphenous vein ablation for polycythemia vera‐associated vascular complications. The wound consistently decreased in size following successive debridements and coverage with human skin equivalent. The wound healed completely after a 6‐month period. A multidisciplinary team approach to the treatment proved to be effective resulting in healing of this multifactorial chr... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5426160 Thu, 17 Nov 2011 05:00:00 +0100 5426160 http://www.medworm.com/index.php?rid=5403567&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00893.x (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5403567 Sun, 13 Nov 2011 22:38:36 +0100 5403567 http://www.medworm.com/index.php?rid=5403566&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00866.x (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5403566 Sun, 13 Nov 2011 22:38:35 +0100 5403566 http://www.medworm.com/index.php?rid=5403565&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00892.x (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5403565 Sun, 13 Nov 2011 22:38:14 +0100 5403565 http://www.medworm.com/index.php?rid=5403564&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00891.x (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5403564 Sun, 13 Nov 2011 22:38:12 +0100 5403564 http://www.medworm.com/index.php?rid=5403563&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00872.x (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5403563 Sun, 13 Nov 2011 22:38:11 +0100 5403563 http://www.medworm.com/index.php?rid=5403561&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00886.x The aim of this study was to evaluate the cytotoxic effect of octenidine dihydrochloride/phenoxyethanol (OHP) found in vitro by conducting a randomized, double‐blind controlled clinical study focusing on its safe and effective use in chronic venous leg ulcers. In total, 126 male and female patients were treated with either OHP (n = 60) or Ringer solution (n = 66). The treatment lasted over a period of maximum 12 weeks. For the assessment of the wound‐healing process, clinical outcome parameters were employed, that is, time span until 100% epithelization, wound status and the wound surface area were analysed. Side effects were recorded during the study period. The median time to complete ulcer healing was comparable between the OHP and Ringer solution groups (92 versus 87 days; P = 0·9... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5403561 Sun, 13 Nov 2011 22:37:30 +0100 5403561 http://www.medworm.com/index.php?rid=5403562&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00822.x The aim of this study was to retrospectively evaluate the clinical and culture‐positive infection rates of open Gustilo/Anderson type II and III fractures using a protocol nanocrystalline silver wound dressing and hydrosurgical debridement. Retrospective case series through chart review on all type II and III open fractures were treated using a novel protocol from December 2005 to March 2008 (N = 17). All Gustilo/Anderson grade II and III open fractures were treated with a novel protocol at a Level I trauma centre. Open Gustilo/Anderson grade II and III fractures were acutely stabilised in the trauma centre/emergency department, while a nanocrystalline silver dressing was placed within the wound. Debridement using a hydrosurgical scalpel and gravity irrigation was performed within 6–8 ... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5403562 Thu, 10 Nov 2011 05:00:00 +0100 5403562 http://www.medworm.com/index.php?rid=5393507&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00881.x This study compared wound healing efficacy of two silver dressings, AQUACEL® Ag and Urgotul® Silver, against venous ulcers at risk of infection, over 8 weeks of treatment. The primary objective was to show non inferiority of AQUACEL® Ag to Urgotul® Silver. Patients (281) were randomised into two groups. The AQUACEL® Ag group had 145 patients treated with AQUACEL® Ag for 4 weeks followed by AQUACEL for another 4 weeks. TheUrgotul® Silver group had 136 patients treated with Urgotul® Silver for 4 weeks followed by Urgotul® for another 4 weeks. In both groups, ulcer size and depth, safety events and ulcer healing were compared. After 8 weeks of treatment, the AQUACEL® Ag group had a relative wound size reduction (49·65% ± 52·53%) compared with the Urgotul® Silver group (42·81% �... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5393507 Wed, 09 Nov 2011 05:00:00 +0100 5393507 http://www.medworm.com/index.php?rid=5393506&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00883.x The aim of the study was to compare three sampling techniques used in routine diagnostics to identify the microbiota in chronic venous leg ulcers. A total of 46 patients with persisting venous leg ulcers were included in the study. At inclusion, swab, biopsy and filter paper pad samples were collected. After 4 weeks, additional biopsy and filter paper pad samples were collected. Bacteria were isolated and identified at species level by standard methods. The most common bacterial species detected was Staphylococcus aureus found in 89% of the ulcers. No methicillin‐resistant S. aureus isolates were found.We did not find any significant differences regarding the bacterial species isolated between the three sampling techniques. However, using multiple techniques led to identification of more... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5393506 Wed, 09 Nov 2011 05:00:00 +0100 5393506 http://www.medworm.com/index.php?rid=5393511&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00867.x Split‐thickness skin grafting (SSG) is a common reconstructive technique for the treatment of patients with deep burns and other traumatic injuries. The management of the donor site after harvesting an SSG remains controversial because of a variety of dressings available for use. The aim of this randomized controlled trial was to compare the effectiveness of a polyurethane dressing, Allevyn™, to a calcium alginate, Kaltostat®. From August 2009 to April 2010, 36 patients were randomized to Allevyn™ or Kaltostat® for donor site management following split skin graft surgery. Pain intensity and adverse events were the primary outcomes assessed. Secondary outcome measures included time for wound healing, ease of application and removal and overall patient satisfaction. Time to first dre... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5393511 Fri, 04 Nov 2011 04:00:00 +0100 5393511 http://www.medworm.com/index.php?rid=5393510&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00837.x Poor vision and poor pain sensation expose sufferers of diabetes to foot burn injuries. A phenomenological approach was used to illuminate the lived experience of those with diabetes who sustained foot burn injuries. Face‐to‐face unstructured interviews were conducted with seven patients recruited from health care facilities throughout Jordan. The interviews were digitally recorded, transcribed verbatim into Arabic, checked for accuracy and then analysed using thematic analysis. Our study highlights that household appliances are a major cause of foot burn injuries among the studied population and that culturally specific risk factors predispose Jordanians with diabetes to foot burn injuries, namely ablution for males and cooking activities for females. Participants sought health care w... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5393510 Fri, 04 Nov 2011 04:00:00 +0100 5393510 http://www.medworm.com/index.php?rid=5393509&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00878.x Osteomyelitis of the calcaneus is a difficult problem to manage. Patients affected by osteomyelitis of the calcaneus often have a below‐the‐knee amputation because of their comorbidity. In this article, we present seven cases of heel ulcerations with chronic osteomyelitis treated with Integra® Dermal Regeneration Template, skin graft and negative pressure wound therapy after partial tangential calcanectomy, discussing the surgical and functional results. In this casuistic of patients, all wounds healed after skin grating of the neodermis generated by Integra®, with no patient requiring a below‐knee amputation. (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5393509 Fri, 04 Nov 2011 04:00:00 +0100 5393509 http://www.medworm.com/index.php?rid=5393508&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00888.x Wound healing is a dynamic and complex biological process, which requires coordinated events including haemostasis, inflammation, proliferation, revascularisation and remodelling. Impaired wound healing is a common problem that occurs in both community and hospital settings. Various experimental and clinical studies have evaluated different modalities for the treatment of topical wounds, such as sugar, antibiotics, honey and phytotherapies; also statins have diverse pleiotropic effects that have been suggested to be useful to improve wound healing. Data derived from both animal and human studies showed that statins especially atorvastatin, simvastatin and pravastatin can accelerate the wound‐healing process. However, further high‐quality and evidence‐based studies are needed to addre... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5393508 Fri, 04 Nov 2011 04:00:00 +0100 5393508 http://www.medworm.com/index.php?rid=5370537&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00877.x The neurosurgery division in University College Hospital (U.C.H.) admits approximately one traumatic spinal cord injured (SCI) patient per week, most of whom stay a minimum of 42 days on admission. A common complication in these patients is the development of pressure ulcers, which contributes to a longer hospital stay and increased hospital expenses. The purpose of this study was to investigate the pattern of presentation of pressure ulcers in patients on admission and to propose policies or protocols to reduce the incidence. It is a prospective study of traumatic SCI patients managed on the neurosurgery ward from January 2003 to June 2004. The data was analysed using descriptive statistics. Sixty‐seven patients were studied. The average hospital stay was 73 days. Thirteen (20%) of the ... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5370537 Fri, 28 Oct 2011 04:00:00 +0100 5370537 http://www.medworm.com/index.php?rid=5327871&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00814.x We analysed the effect of different body features on contact area, interface pressure and pressure distribution of three different mattresses. Thirty‐eight volunteers (age ranged from 17 to 73 years, 23 females) were asked to lie on three different mattresses in a random order: I, standard hospital foam mattresses; II, higher specification foam mattresses (Viscorelax Sure®); III, constant low pressure devices (CareMedx®, AirSystems). Measurements were performed in supine position and in a 90° left‐ and right‐sided position, respectively, using a full‐body mat (pressure mapping device Xsensor X2‐Modell). Outcome variables were contact area (CA) in cm2, mean interface pressure (IP) in mmHg and pressure distribution (PD) estimated as rate of low pressures between 5 and 33 mmHg on... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5327871 Mon, 17 Oct 2011 04:00:00 +0100 5327871 http://www.medworm.com/index.php?rid=5308744&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00871.x Higher closure rates of the open abdomen have been reported with negative pressure wound therapy (NPWT) than with other kinds of wound management. We have recently shown that NPWT decreases the blood flow in the intestinal wall, and that the blood flow could be restored by inserting a protective disc over the intestines. The aim of the present study was to investigate whether layers of Jelonet™ (Smith & Nephew) dressing (paraffin tulle gras dressing made from open weave gauze) over the intestines could protect the intestines from hypoperfusion. Midline incisions were made in ten pigs and were subjected to treatment with NPWT with and without four layers of Jelonet over the intestines. The microvascular blood flow was measured in the intestinal wall before and after the application of... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5308744 Tue, 11 Oct 2011 04:00:00 +0100 5308744 http://www.medworm.com/index.php?rid=5308745&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00873.x (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5308745 Mon, 10 Oct 2011 04:00:00 +0100 5308745 http://www.medworm.com/index.php?rid=5290312&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00870.x Chronic venous leg ulcers are a major health issue and represent an often overlooked area of biomedical research. Nevertheless, it is becoming increasingly evident that new approaches to enhance healing outcomes may arise through better understanding the processes involved in the formation of chronic wounds. We have for the first time shown that the terminal purine catabolite uric acid (UA) is elevated in wound fluid (WF) from chronic venous leg ulcers with relative concentrations correlating with wound chronicity. We have also shown a corresponding depletion in UA precursors, including adenosine, with increased wound severity. Further, we have shown that xanthine oxidase, the only enzyme in humans that catalyses the production of UA in conjunction with a burst of free radicals, is active ... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5290312 Tue, 04 Oct 2011 04:00:00 +0100 5290312 http://www.medworm.com/index.php?rid=5393505&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00890.x This study reports differential expression of miRNAs related to cell development and differentiation, during wound healing in diabetic mice. Comparison of skin tissue from normal and diabetic mice showed that 14 miRNAs were differentially expressed in diabetic skin; miR‐146b and miR‐21 were the most noteworthy. Expression pattern of these miRNAs was also altered during healing of diabetic wounds. A subset of miRNAs (miR‐20b, miR‐10a, miR‐10b, miR‐96, miR‐128, miR‐452 and miR‐541) exhibited similar basal levels in normal and diabetic skins, but displayed dysregulation during healing of diabetic wounds. Amongst the miRNAs studied, miR‐21 showed a distinct signature with increased expression in diabetic skin but decreased expression during diabetic wound healing. We analys... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5393505 Sat, 01 Oct 2011 04:00:00 +0100 5393505 http://www.medworm.com/index.php?rid=5370536&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00882.x In this study, we describe, to the best of our knowledge, the first report of LV only associated with sickle cell trait with significant improvement on aspirin. (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5370536 Sat, 01 Oct 2011 04:00:00 +0100 5370536 http://www.medworm.com/index.php?rid=5327869&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00874.x This article is in two parts. The overall aim of this section was to review the literature in relation to pilonidal sinus wounds (PSW) healing by secondary intent for a Master's of Science in Wound Healing and Tissue Repair thesis. The purpose of the literature review was to determine if an evidence‐based guideline or consensus document existed for the care of these wounds, and if not, to determine the topics from which to develop items for the first round of a modified reactive Delphi questionnaire. Part two will describe the iterative process, the analysis and the results. The review found no best practice guidelines concerning PSW, and only one clinical pathway. Seventeen areas of interest were identified that may contribute to optimal healing conditions or to delayed healing. These i... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5327869 Sat, 01 Oct 2011 04:00:00 +0100 5327869 http://www.medworm.com/index.php?rid=5308743&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00876.x This study involves 20 patients with chronic venous ulcers at least 6 weeks of duration treated with negative pressure wound therapy (NPWT). Patients underwent a radical debridement of all devitalised tissues in the first operation. After adequate haemostasis, silver‐impregnated polyurethane foam was applied. Once the wounds were determined to be clean and adequate granulation tissue formation was achieved, split‐thickness skin grafts were applied. Black polyurethane foam was applied over them. All wounds completely healed without the need for further debridement or regrafting. The mean number of silver‐impregnated foam dressing changes prior to grafting was 2·9 (one to eight changes). The mean number of NPWT foam changes was 2·6 after skin grafting (two to five changes). Two patie... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5308743 Sat, 01 Oct 2011 04:00:00 +0100 5308743 http://www.medworm.com/index.php?rid=5300086&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00844.x We report a patient with persistent fistulas, in whom conventional medical and surgical therapy failed. In this case, most of fistulas in gluteofemoral region were completely healed and closed after 6 months of treatment with honey. In addition, honey reduced inflammation, pain and induration of affected region. This medical approach positively affected patient's mental condition and also improved his quality of life. (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5300086 Sat, 01 Oct 2011 04:00:00 +0100 5300086 http://www.medworm.com/index.php?rid=5290311&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00836.x The integrity of human skin is central to the prevention of infection. Acute and chronic wounds can develop when the integrity of skin as a barrier to infection is disrupted. As a multi‐functional organ, skin possesses important biochemical and physical properties that influence its microbiology. These properties include a slightly acidic pH, a low moisture content, a high lipid content (which results in increased hydrophobicity) and the presence of antimicrobial peptides. Such factors have a role to play in preventing exogenous microbial colonisation and subsequent infection. In addition, the properties of skin both select for and enhance colonisation and biofilm formation by certain ‘beneficial’ micro‐organisms. These beneficial micro‐organisms can provide further protection ag... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5290311 Sat, 01 Oct 2011 04:00:00 +0100 5290311 http://www.medworm.com/index.php?rid=5255181&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00869.x In many series of diabetic foot ulcer care, heel ulcers greater than 4 cm across have been identified as an independent predictor of limb loss. Therefore, we set out to pursue the most aggressive limb salvage algorithm in patients with heel ulcers greater than 4 cm in diameter. Over 5 years, we identified 21 patients, 39–84 years of age, all with diabetes mellitus, with heel ulcers greater than 4 cm in diameter and had magnetic resonance imaging or bone scan evidence of osteomyelitis. Seven of the 21 patients had end‐stage renal disease defined as being haemodialysis dependent. All patients had ankle brachial indices <0·4 or monophasic pulse volume recordings. All patients underwent distal bypass surgery with vein. After adequate perfusion was obtained, all patients underwent parti... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5255181 Mon, 26 Sep 2011 15:44:34 +0100 5255181 http://www.medworm.com/index.php?rid=5255182&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00860.x This retrospective analysis included intent‐to‐treat control patient data from two published, randomised, diabetic foot ulcer (DFU) trials in an effort to differentiate ulcers that are unlikely to heal by 12 weeks despite early healing progress [≥50% percent area reduction (PAR) at 4 weeks]. Predicted and actual wound area trajectories in DFUs that achieved early healing progress were analysed from weeks 5 to 12 and compared for ulcers that did and did not heal at 12 weeks. In 120 patients who achieved ≥50% PAR by week 4, 62 (52%) failed to heal by 12 weeks. Deviations from the predicted healing course were evident by 6 weeks for non healing ulcers. A 2‐week delay in healing significantly lowered healing rates (P = 0·001). For DFUs with ≥50% PAR at 4 weeks, those achieving ≥... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5255182 Fri, 23 Sep 2011 04:00:00 +0100 5255182 http://www.medworm.com/index.php?rid=5243737&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00853.x Pulsed radio frequency energy (PRFE) has successfully been used to treat diabetic and venous stasis ulcers. In this case report, a lightweight wearable form of a PFRE device was evaluated and used to treat three diabetic foot ulcers and one venous stasis ulcer. The ulcers were present on the four patients for more than 3 months and had failed to heal after conventional treatment. A lightweight battery‐powered, wearable form of PRFE device was introduced as a treatment and used 6–8 hours per day for a period of 6 weeks. All patients after 1 week of therapy showed improvement and wound size was seen to decrease. Patient 1 had a venous stasis ulcer, and reported significant pain relief after 2 weeks treatment. Patients 2 and 3 achieved complete healing after 3 weeks treatment, and patient... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5243737 Fri, 23 Sep 2011 00:05:07 +0100 5243737 http://www.medworm.com/index.php?rid=5229995&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00864.x (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5229995 Mon, 19 Sep 2011 13:23:40 +0100 5229995 http://www.medworm.com/index.php?rid=5229994&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00859.x We report herein that a clinical Good Manufacturing Practice‐grade vitronectin:growth factor (cVN:GF) complex is able to stimulate functions relevant to wound repair in vitro, such as enhanced cellular proliferation and migration. Furthermore, we assessed this complex as a topical wound healing agent in a single‐arm pilot study using venous leg ulcers, as well as several ‘difficult to heal’ case studies. The cVN:GF complex was safe and re‐epithelialisation was observed in all but 1 of the 30 patients in the pilot study. In addition, the case studies show that this complex may be applied to several ulcer aetiologies, such as venous leg ulcers, diabetic foot ulcers and pressure ulcers. These findings suggest that further evaluation is warranted to determine whether the cVN:GF compl... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5229994 Mon, 19 Sep 2011 13:23:34 +0100 5229994 http://www.medworm.com/index.php?rid=5229993&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00784.x This study aims to assess the relationship between changes in tcpO2, measured under basal (39°C) and stimulated (44°C) conditions and healing rate of chronic wounds over 4 weeks, to determine whether tcpO2 measurement can predict delayed wound healing. TcpO2 (Radiometer TCM400) measurements at sensor temperatures 39 and 44°C were recorded (twice, 4 weeks apart) adjacent to the ulcer site, and at a mirror image site on the contralateral leg. Ulcer outline was traced on clear acetate and perimeter and area measured (Visitrak™, Smith and Nephew). TcpO2 measured at 44 and 39°C adjacent to all 13 wounds were lower compared to the contralateral site, significant at 44°C (P = 0·008). Significant correlation (r2 = 0·8) occurred between wound healing rate and increased tcpO2 at 44°C over ... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5229993 Mon, 19 Sep 2011 13:23:18 +0100 5229993 http://www.medworm.com/index.php?rid=5229992&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00863.x (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5229992 Mon, 19 Sep 2011 13:23:16 +0100 5229992 http://www.medworm.com/index.php?rid=5229991&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00862.x (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5229991 Mon, 19 Sep 2011 13:23:15 +0100 5229991 http://www.medworm.com/index.php?rid=5229990&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00861.x (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5229990 Mon, 19 Sep 2011 13:23:13 +0100 5229990 http://www.medworm.com/index.php?rid=5229989&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00850.x The incidence of tetanus in patients with wounds is unknown; however, recently concern has been raised over the proportion of tetanus cases in which a chronic wound is the portal of entry for Clostridium tetani. Varicose ulcers, dermatosis and necrosed tumours are estimated to be the point of entry for C. tetani spores in 11–14% of three cases. Of diabetic patients in the USA who contracted tetanus, a diabetic foot ulcer was responsible in 25% of cases despite this chronic wounds have yet to be considered as a risk factor for tetanus. An audit was undertaken and a survey devised to form the basis of the data collection to assess if patients with chronic wounds are up‐to‐date in accordance with the tetanus immunisation programme. Over a 5‐day period, the data were prospectively coll... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5229989 Mon, 19 Sep 2011 13:22:41 +0100 5229989 http://www.medworm.com/index.php?rid=5214931&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00840.x Repair machinery and local infection control failure contribute to wound chronicity and lower extremity amputation in diabetic patients. In these wounds, inflammation is a proximal condition which disrupts wound matrix turnover and the local redox balance. Contemporary therapeutic interventions are relatively broad including drugs, devices and surgical procedures. However, clinical efficacy remains modest and recurrences are frequent. Recombinant growth factors advent was followed by their premature and empiric introduction in the clinical practice. Its topical administration is still challenged by local kinetic and pharmacodynamic limitations related to the hostile microenvironment of chronic wounds. The rationale of infiltrating epidermal growth factor (EGF) down inside complex diabetic ... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5214931 Tue, 13 Sep 2011 04:00:00 +0100 5214931 http://www.medworm.com/index.php?rid=5214929&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00868.x This study determined if wound care registry outcomes could be an alternative data source and if the results would be robust and valid. Changes in wound area and depth were hypothesised to be different between run‐in therapies and platelet‐rich plasma (AutoloGel™, Cytomedix, Inc) treatment. From a treatment registry of 285 chronic wounds, 46 had run‐in and post‐treatment data. Seven chronic wound categories were identified. Mean wound age at study start was 52·4 days. General linear model repeated measures showed a credible and robust data set. Statistically significant differences for wound area and depth were observed between run‐in and post‐treatment period at multiple time points. Wound area and depth ≥50% reduction were analysed using Kaplan–Meier methods. During ru... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5214929 Tue, 13 Sep 2011 04:00:00 +0100 5214929 http://www.medworm.com/index.php?rid=5214928&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00851.x This study aimed to determine the prevalence of lymphoedema among persons attending wound management and vascular clinics in an acute tertiary referral hospital. Four hundred and eighteen patients meeting the inclusion criteria were assessed. A prevalence rate of 2.63% (n = 11) was recorded. Thirty‐six percent (n = 4) had history of cellulitis and broken skin, 64% (n = 7) had history of broken skin and 36% (n = 4) had undergone treatment for venous leg ulcers. The most common co‐morbidities were hypertension 55% (n = 6), deep vein thrombosis (DVT) 27% (n = 3), hypercholesterolemia 36% (n = 4) and type 2 diabetes 27% (n = 3). Quality of life scores identified that physical functioning was the domain most affected among this group. This study has identified the need to raise awareness of... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5214928 Tue, 13 Sep 2011 04:00:00 +0100 5214928 http://www.medworm.com/index.php?rid=5214927&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00852.x The purpose of this study was to determine the relationship between the scores of Braden scale and pressure ulcer development among critically ill patients. All patients who admitted to intensive care unit (ICU) in 3 months (during July–October 2010) were surveyed with Braden scale. Patients who gained higher score of Braden scale were at lower risk for pressure ulcer development compared with the other patients. Braden scale is a useful tool for predicting pressure ulcer development in trauma ICU patients. Also, factors such as age and level of consciousness may influence pressure ulcer development. (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5214927 Tue, 13 Sep 2011 04:00:00 +0100 5214927 http://www.medworm.com/index.php?rid=5188751&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00838.x Combining silver‐based dressings with negative pressure therapy after radical excision of chronically infected breast disease is a novel application of two technologies. One patient with complex, chronic, infected breast disease underwent radical excision of the affected area and was treated early with a combination of silver‐based dressings and topical negative pressure therapy. The wound was then assessed sequentially using clinical measurements of wound area and depth, pain severity scores and level of exudation. It is possible to combine accepted techniques with modern dressing technologies that result in a positive outcome. In this case, the combination of a silver‐based dressing with negative pressure therapy following radical excision proved safe and was well tolerated by the ... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5188751 Tue, 30 Aug 2011 23:00:00 +0100 5188751 http://www.medworm.com/index.php?rid=5188750&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00847.x The aim of our case report was to analyse the results obtained with the Matriderm® system and autologous skin grafting for the surgical treatment of skin necrosis of scrotum as a result of endovascular embolisation. We recruited one patient with scrotum skin necrosis as a result of endovascular embolisation admitted at the department of Plastic and Reconstructive surgery, University of Rome ‘Tor Vergata’. The patient underwent Matriderm® system and autologous skin grafting for skin necrosis treatment. After a single treatment, reduction of the skin necrosis was obtained, after 30 days from the surgical treatment. Patient experienced a reduction in pain and a complete restoration of the loss in volume and quality of skin was noticed. Matriderm® system and autologous skin grafting is ... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5188750 Tue, 30 Aug 2011 23:00:00 +0100 5188750 http://www.medworm.com/index.php?rid=5188749&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00843.x Small intestine submucosa (SIS), a bioactive extracellular matrix (ECM) containing critical components of the ECM including collagens, proteoglycans, and glycosaminoglycans, has been widely used for wound healing. The purpose of this study was to investigate the interaction between SIS and matrix metalloproteinases (MMPs). MMP‐1, MMP‐2, and MMP‐9 displayed different binding affinities, indicated by a loss in activity in solution upon incubation with SIS at 53·8%, 85·9%, and 36·9% over 24 hours, respectively. A cell migration study was conducted to evaluate the effects of MMPs and SIS on keratinocytes. The results indicated that MMPs inhibit keratinocyte migration in vitro, and that the inhibition can be significantly reduced by pre‐incubating the MMP solution with SIS. To evalua... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5188749 Tue, 30 Aug 2011 23:00:00 +0100 5188749 http://www.medworm.com/index.php?rid=5152132&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00830.x Delayed wound healing in diabetes is a challenging medical and societal problem for which there is currently no efficacious treatment. One of the major contributors of this problem is nitric oxide (NO) deficiency. NO is a critical signalling molecule essential for normal wound repair. Sustained hyperglycaemia in diabetes leads to increased vascular superoxide production, which inactivates NO and causes vascular dysfunction. New therapeutic regiments and strategies to enhance endothelial NO production are a new hope to improve impaired diabetic wound healing. One of the agents that have the ability to improve endothelial NO generation in diabetic patients is folic acid. Folic acid ability to conserve NO bioactivity may be due to homocysteine‐lowering effects of folates, antioxidant action... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5152132 Thu, 18 Aug 2011 23:00:00 +0100 5152132 http://www.medworm.com/index.php?rid=5152131&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00835.x Our study reviewed nine patients who were treated with the VAC™ Abdominal Dressing System after suffering pelvic fractures and soft tissue loss after high‐energy pelvic trauma. Between March 2008 and August 2009, our clinic treated nine patients with complicated perineal injuries from high‐energy pelvic trauma with multiple irrigation and debridement procedures and broad‐spectrum antibiotics. Protective ostomies were created for all nine patients. Required interventions were made for associated injuries, and VAC™ application was started. All patients were male, with an average age of 24·3 (range 21–32) years, and a mean injury severity score of 36·4 (range 16–59). Wound diameters ranged from 15 to 30 cm, and wound depths ranged from 5 to 25 cm. The injuries included one tra... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5152131 Thu, 18 Aug 2011 23:00:00 +0100 5152131 http://www.medworm.com/index.php?rid=5152130&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00841.x This article is based on a second Hygienist Panel meeting held in London on 16–17 June 2010. The Panel discussed the current use of antimicrobials and care bundles in the prevention of surgical site infection; the need to comply with good antibiotic stewardship, to reduce the risk of antibiotic‐resistant and emergent organisms; and the need to revisit the use of antiseptics. The discussion was driven by concerns of the use of triclosan, which had been raised by a publication from the Scientific Committee on Consumer Products of the Directorate General for Health and Consumers, European Commission. Uncertainties that excessive use of triclosan for preservation and in cosmetics could select naturally resistant environmental organisms or induce reduced triclosan‐susceptibility or antibi... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5152130 Thu, 18 Aug 2011 23:00:00 +0100 5152130 http://www.medworm.com/index.php?rid=5152129&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00846.x We present the case of a young man with type II diabetes, stage III chronic kidney disease, hypertension, obstructive sleep apnea and diabetes who presented to the Georgetown University Hospital Center for Wound Healing with refractory lower extremity ulcers. Autoimmune work‐up was negative. However, chromosome analysis showed a genetic variant of Klinefelter's syndrome (48 XXYY). Lower extremity ulceration is a recognised complication of Klinefelter's syndrome. The pathogenesis of ulcers in this endocrinopathy is unclear, but associations with abnormalities of fibrinolysis and prothrombotic states are reported. This case emphasises the importance of considering Klinefelter's syndrome in the differential diagnosis of a sterile male patient with non healing lower extremity ulcers. (Source... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5152129 Thu, 18 Aug 2011 23:00:00 +0100 5152129 http://www.medworm.com/index.php?rid=5152135&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00825.x (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5152135 Tue, 16 Aug 2011 23:00:00 +0100 5152135 http://www.medworm.com/index.php?rid=5152134&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00845.x This article explores the professional challenges of treating patients with complex/severe forms of chronic oedema/lymphoedema with compression therapy. Four focus groups were held, two in the UK and two in Canada, to examine the challenges faced by practitioners in their everyday practice. A number of challenges were identified by participants in both countries and include the changing profile of lymphoedema/chronic oedema and how increasing complexity is outpacing the development of services and research‐based guidelines. Focus groups also highlighted a lack of public awareness, poor professional knowledge, delayed diagnosis and inappropriate treatment as having a significant impact on practice. Other practice‐related issues include a poor understanding of treatment options among pra... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5152134 Tue, 16 Aug 2011 23:00:00 +0100 5152134 http://www.medworm.com/index.php?rid=5152133&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00832.x This article reports on a qualitative study that explored the experience of patients who have undergone a period of complete decongestive therapy using the 3M™ Coban™ 2 compression system (Coban 2 system). Qualitative data were collected from 12 patients from the UK and 8 from Canada with a range of presentations of lymphoedema. Single semi‐structured interviews were used and participants were asked questions relating to their experience of diagnosis, the impact of lymphoedema on their lives, previous treatment using multilayer lymphoedema bandaging and their experiences of the 3M™ Coban™ 2 system. Treatment with multilayer lymphoedema bandaging was seen as constraining in that it was tiring, time consuming, heavy, bulky and led to feelings of clumsiness and a restricted life. Tr... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5152133 Tue, 16 Aug 2011 23:00:00 +0100 5152133 http://www.medworm.com/index.php?rid=5123191&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00824.x This paper reports on a successful nurse practitioner‐led Pressure Ulcer Prevention Program (PUPP), established with members from nursing, allied health and senior management, within a regional area health service in Australia. The aims of PUPP were to quantify the prevalence of pressure ulcers within the health organisation, evaluate the policy compliances, identify cost effectiveness by implementing appropriate pressure redistributing surfaces and raise awareness of pressure ulcer prevention amongst all levels of clinical staff. The strategies include annual point prevalence study across 41 facilities, mattress replacement and online education program. The prevalence survey data were collected by skin inspection and chart audits by the trained surveyors. Since this quality improvement ... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5123191 Mon, 08 Aug 2011 23:00:00 +0100 5123191 http://www.medworm.com/index.php?rid=5123190&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00831.x We present an interesting case of malignant degeneration in a male paraplegic patient with chronic sacral and ischial pressure sores. By discussing our radical surgical solution to this problem, we aim to highlight the importance of prompt diagnosis. (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5123190 Mon, 08 Aug 2011 23:00:00 +0100 5123190 http://www.medworm.com/index.php?rid=5123189&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00812.x (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5123189 Mon, 08 Aug 2011 23:00:00 +0100 5123189 http://www.medworm.com/index.php?rid=5123188&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00821.x Wounds can be caused by different mechanisms and have a significant morbidity and mortality. Negative pressure wound therapy (NPWT) is one of the most successful treatment modalities for wound healing. We have been using both foam and gauze‐based NPWT. During application of NPWT, we noticed that the patient's pain was of varying intensity depending on the filler used. The aim of our work was to compare the level of pain and feedback before, during the treatment and at the dressing change after treatment with NPWT with two different fillers. For this study, we compared a pool of 13 gauze‐treated patients with a pool of 18 foam‐treated patients regarding the level of pain and feedback before, during the treatment and at the dressing change after treatment with NPWT. They were all post�... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5123188 Mon, 08 Aug 2011 23:00:00 +0100 5123188 http://www.medworm.com/index.php?rid=5123187&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00834.x The management of non‐healing leg ulcers in patients with CREST syndrome and subdermal calcification is rarely reported in medical literature. Only one similar case was found in the literature (1). Dealing with such patients can be a challenge for wound specialists. In this article, we discuss the clinical progress of an interesting case of extensive non‐healing leg ulcers in a CREST patient with dystrophic calcification. The combination of systemic physiological deficits and immune compromise, along with the local physical abnormalities associated with the wound pose a complex multifactorial aetiological mix. There is no conclusive data on the optimal management of these wounds in CREST patients. It seems that ablation of the calcific deposits may offer some hope. (Source: Internation... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5123187 Mon, 08 Aug 2011 23:00:00 +0100 5123187 http://www.medworm.com/index.php?rid=5100951&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00823.x Activated leukocyte cell adhesion molecule (ALCAM) is a glycoprotein of the immunoglobulin superfamily that has been implicated in the processes of cell adhesion and migration. The current study examines the importance of ALCAM in regulating HaCaT cell growth and migration and its potential to impact on wound healing. ALCAM levels were examined in a range of clinical wound and normal skin samples using Q‐PCR and immunohistochemistry. ALCAM expression was targeted in HaCaT keratinocyte cells using a hammerhead ribozyme transgene system. Subsequently, the impact of ALCAM suppression on HaCaT migration and growth was assessed. ALCAM protein was detected mainly in keratinocytes. ALCAM transcript levels were found to be significantly higher in the non‐healed chronic wound samples compared w... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5100951 Wed, 03 Aug 2011 23:00:00 +0100 5100951 http://www.medworm.com/index.php?rid=5214926&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00865.x Current heel protection devices used in the operating room do not comply with the consensus document of the European and National (North American) Pressure Ulcer Advisory Panels. A complying prototype has been tested. Prospective cohort study comparing interface pressures. While using the prototype device, the heel interface pressure is significantly [mean 0·0 mmHg, standard deviation (SD) 0·0] less than the viscose elastic gel (VEG) mat (mean 174·8 mmHg, SD 64·5), the Action® heel block (mean 182·3 mmHg, SD 70·8) and the theatre table (mean 193·2 mmHg, SD 57·1). At the Achilles tendon, the prototype device (mean 16·2 mmHg, SD 19·0) is significantly superior to the Oasis (mean 183·7 mmHg, SD 67·4) and Action® heel blocks (mean 112·3 mmHg, SD 64·7). At the lateral malleolus,... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5214926 Mon, 01 Aug 2011 04:00:00 +0100 5214926 http://www.medworm.com/index.php?rid=5201176&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00842.x We describe an alternative method for scar revision that may be applicable in certain situations. Instead of expanding the soft tissues to make available additional skin, deflation by liposuction may be affected to relax the skin envelope thus indirectly providing additional skin for scar revision. We call this method ‘reverse tissue expansion’. (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5201176 Mon, 01 Aug 2011 04:00:00 +0100 5201176 http://www.medworm.com/index.php?rid=5188748&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00848.x Fractionated irradiation (IR) before or after surgery of malignant tumours causes a high frequency of wound healing complications. Our aim was to investigate the effect of curcumin (CUM) on the healing of deep excision wound of mice exposed to fractionated IR by mimicking clinical conditions. A full‐thickness dermal excision wound was created on the shaved dorsum of mice that were orally administered or not with 100 mg of CUM per kilogram body weight before partial body exposure to 10, 20 or 40 Gy given as 2 Gy/day for 5, 10 or 20 days. The wound contraction was determined periodically by capturing video images of the wound from day 1 until complete healing of wounds. Fractionated IR caused a dose‐dependent delay in the wound contraction and prolonged wound healing time, whereas CUM ad... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5188748 Sun, 31 Jul 2011 23:00:00 +0100 5188748 http://www.medworm.com/index.php?rid=5166758&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00839.x We present three cases of Absidia corymbifera necrotising fasciitis presenting to our centre within 1 month of each other. All patients had wound dressings with non sterile crepe bandages at peripheral centres. One patient was lost to follow‐up, another improved on timely antifungal therapy, while the last patient succumbed to disseminated infection. We propose that traumatic and deep wounds be dressed with sterile roller bandages to prevent outbreaks of wound zygomycosis. (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5166758 Sun, 31 Jul 2011 23:00:00 +0100 5166758 http://www.medworm.com/index.php?rid=5152128&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00849.x Diabetic patients are at increased risk of complicated skin, skin structure and bone infections including infections of diabetic foot ulcerations (DFU). Analyses of epidemiology and microbial pathogenicity show that staphylococci seem to be predestined to induce such infections. In addition, multidrug resistance particularly due to an increasing prevalence of methicillin‐resistant Staphylococcus aureus (MRSA) seems to be the challenge for effective antibiotic therapy. With regard to infections with MRSA, classical agents like vancomycin, linezolid, fosfomycin or trimethroprim–sulphametoxazol might be agents of choice in DFU. New‐generation drugs including broad‐spectrum tetracyclines like tigecycline, first and second generation of cyclic lipopeptides, anti‐MRSA β‐lactams incl... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5152128 Sun, 31 Jul 2011 23:00:00 +0100 5152128 http://www.medworm.com/index.php?rid=5123186&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00819.x This article describes the development of a novel and intuitive strapping technique overlying the compression bandage that appears to have an influence in healing complex lower limb ulcers. A retrospective audit of 17 patients with 25 ulcers allows further analysis and discussion. The strapping technique uses cohesive inelastic compression bandaging; narrow strips of bandages are layered in a fan distribution over the ulcer and oedema. This approach seems to offer an intuitive response to these complex wounds, allowing management to be tailored to the site of the ulcer and oedema. Tolerance for this less bulky compression therapy regime is excellent, thereby aiding healing and reducing all costs associated with non healing leg ulcers. (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5123186 Sun, 31 Jul 2011 23:00:00 +0100 5123186 http://www.medworm.com/index.php?rid=5100950&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00833.x In recent years, oxidative stress and free radicals have been implicated in impaired wound healing. Grape (Vitis vinifera) seed extract (GSE) possesses anti‐inflammatory and antioxidant properties. The present study was undertaken to assess the potential activity of grape seed hydroalcoholic extract in wound healing in rabbits. Rabbits of either sex were subjected to a 20 × 20 mm square excision made over the skin of the back. The animals were randomly divided into seven experimental groups, as negative and positive control, eucerin and treatments. Negative control group did not receive any treatment. Positive control and eucerin groups received phenytoin cream (1%) and topical eucerin, respectively, twice a day from the beginning of experiments to complete wound closure. Treatment grou... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5100950 Sun, 31 Jul 2011 23:00:00 +0100 5100950 http://www.medworm.com/index.php?rid=5014759&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00829.x (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5014759 Tue, 12 Jul 2011 16:50:55 +0100 5014759 http://www.medworm.com/index.php?rid=5014758&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00828.x (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5014758 Tue, 12 Jul 2011 16:50:46 +0100 5014758 http://www.medworm.com/index.php?rid=5014757&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00808.x (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5014757 Tue, 12 Jul 2011 16:50:45 +0100 5014757 http://www.medworm.com/index.php?rid=5014756&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00827.x (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5014756 Tue, 12 Jul 2011 16:50:45 +0100 5014756 http://www.medworm.com/index.php?rid=5014755&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00826.x (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=5014755 Tue, 12 Jul 2011 16:50:44 +0100 5014755 http://www.medworm.com/index.php?rid=4989751&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00817.x Pressure ulcer prevention needs nurses' awareness of sore classification/onset, its item characteristics, and its prevention. Using Pieper's Pressure Ulcer Knowledge Test, 126 critical care nurses' knowledge about pressure ulcer was examined. The questionnaire was divided into three categories including: (1) sore classification/onset; (2) wound characteristics, and (3) preventive measure. The level of nurse's knowledge was insufficient. The highest rate of correct answers belonged to section 2 – prevention of pressure ulcer. Programs aimed at raising nurses' knowledge accompanied by interventions intended to decrease incidence of pressure ulcer are important parts in educational programs. Continuing education may need to be added to the pressure ulcer care to improve the quality of care ... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=4989751 Thu, 30 Jun 2011 23:00:00 +0100 4989751 http://www.medworm.com/index.php?rid=4989750&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00818.x The objectives of the study were to examine the prevalence of pressure ulcers and hospital‐acquired pressure ulcers (HAPU) and identify modifiable factors in patients who develop HAPU as the basis for subsequent quality assurance studies and improvement in hospital care. The study was conducted in five hospitals in two Swedish County Councils. A 1‐day prevalence study (n = 1192) using the standards of the European Pressure Ulcer Advisory Panel and Collaborative Alliance for Nursing Outcomes was conducted. The prevalence of ulcers was 14·9% and 11·6% were HAPU. Older age, more days of hospitalisation, less activity, problems with shear and friction and reduced sensory perception contributed significantly to HAPU. Pressure ulcer prevention strategies used more often in those with HAPU ... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=4989750 Thu, 30 Jun 2011 23:00:00 +0100 4989750 http://www.medworm.com/index.php?rid=4989749&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00820.x Haruan (Channa striatus) is a type of fresh water fish in Malaysia that is known to promote wound healing. Haruan water extract has been formulated in an aerosol system which can produce a film for wound dressing. As topical preparation, Haruan spray needs to be evaluated in terms of the possibility to cause irritation reaction or toxic response. Three experiments were carried out to evaluate the safety of Haruan spray which are Primary Skin Irritation test, Intracutaneous test and Systemic Injection test. The result shows that Haruan spray gave no significant responses to all the above tests. The investigation of the effect of Haruan spray as wound dressing in the healing process was performed in Sprague‐Dawley rats where 6‐cm long full‐thickness incision wound and burn wound were m... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=4989749 Tue, 31 May 2011 23:00:00 +0100 4989749 http://www.medworm.com/index.php?rid=4958048&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00816.x Right ventricular heart rupture is a devastating complication associated with negative pressure wound therapy (NPWT) following cardiac surgery. The use of a rigid disc has been suggested to offer protection against this lethal complication by preventing the heart from being drawn up towards, and damaged by, the sharp sternum edges. The aim of the present study was to compare the wound fluid evacuation from the pericardium and the left pleura when using NPWT with such a disc between the sternal edges and the heart, and when using conventional NPWT. Six pigs underwent median sternotomy followed by NPWT at −120 mmHg, using foam, with or without a rigid plastic disc between the heart and the sternal edges. A 250 ml saline was infused into the pericardium, and the time required for fluid evac... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=4958048 Tue, 31 May 2011 23:00:00 +0100 4958048 http://www.medworm.com/index.php?rid=4899283&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00800.x This study shows that polyhexanide and octenidine improve muscular perfusion. Interestingly, the benefit of polyhexanide and octenidine on muscular perfusion is eliminated when the antiseptics are combined with other vasoactive agents, especially β blockers. (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=4899283 Tue, 31 May 2011 23:00:00 +0100 4899283 http://www.medworm.com/index.php?rid=4868922&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00789.x A prospective, randomised study was conducted to compare the wound closure performance and cosmetic outcome of caesarean section wounds closed with traditional Prolene suture or a new wound closure device (Leukosan® SkinLink). Sixty‐one patients referred to primary section were allocated to wound closure with either Leukosan® SkinLink or Prolene suture. Cosmetic outcome as the primary measure was evaluated by the patient, the surgeon as well as by independent examiners blinded to the method of wound closure. Evaluations were recorded at 3, 6 and 12 months following wound closure. Both methods of wound closure scored equally high on the visual analogue scale for cosmetic evaluation at the 3‐, 6‐ and 12‐month follow‐ups as assessed by the patient, surgeon and the blinded observer... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=4868922 Fri, 27 May 2011 18:15:36 +0100 4868922 http://www.medworm.com/index.php?rid=4837360&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00815.x Management of patients with large or recurrent pressure ulcerations can be complicated by the lack of available local flap, whether already used or because adjacent lesions make such flap insufficient for complete coverage. In this article, the gracilis muscle was modified to cover large defects without help from its cutaneous territory. Twelve ischeal pressure sores were treated between August 2007 and 2009 with the modified gracilis muscle flap in a single‐staged procedure. Five ulcers were recurrent and seven patients have associated pressure ulcers. All reconstructions were successful. Mean patient age was 35 years and nearly all patients had multiple significant comorbidities, including associated ulcers, diabetes and urethrocutaneous fistula. All flaps and donor sites healed uneven... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=4837360 Thu, 19 May 2011 16:35:48 +0100 4837360 http://www.medworm.com/index.php?rid=4837361&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00813.x This article introduces refined techniques, indications and the clinical experience of the application of negative pressure wound therapy (NPWT) as an easy ancillary wound dressing method for the reconstruction of large or difficult skin and soft tissue defects. The authors used NPWT on 88 patients as an adjuvant therapy before reconstructive surgery since 2006. NPWT was applied for two different treatment strategies: as an adjuvant therapy to facilitate the formation of a healthy wound bed and to reduce the size and depth of a defect. NPWT was used as an alternative dressing method for skin grafting for infants or mobile skin surfaces such as the neck, penis, dorsum of the hand, knee joint, abdomen, etc. There were no typical wound complications. NPWT application, if used appropriately, p... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=4837361 Wed, 18 May 2011 23:00:00 +0100 4837361 http://www.medworm.com/index.php?rid=4837365&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00803.x In conclusion, the results of this haemodynamic study show that a rigid disc can safely be placed over the heart during NPWT, to prevent heart rupture. The haemodynamic effects of NPWT in sternotomy wounds are slightly reduced by the presence of the rigid disc. (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=4837365 Mon, 16 May 2011 23:00:00 +0100 4837365 http://www.medworm.com/index.php?rid=4837364&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00804.x (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=4837364 Mon, 16 May 2011 23:00:00 +0100 4837364 http://www.medworm.com/index.php?rid=4837363&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00805.x This study was performed to examine the effect of NPWT on wound contraction and fluid evacuation in the presence of a rigid disc. Peripheral wounds were created on the backs of eight pigs. The wounds were filled with foam, and rigid discs of different designs were inserted between the wound bed and the foam. Wound contraction and fluid evacuation were measured after application of continuous NPWT at −80 mmHg. Wound contraction was similar in the presence and the absence of a rigid disc (84 ± 4% and 83 ± 3%, respectively, compared with baseline). Furthermore, the rigid disc did not affect wound fluid removal compared with ordinary NPWT (e.g. after 120 seconds, 71 ± 4 ml was removed in the presence and 73 ± 3 ml was removed in the absence of a disc). This study shows that a rigid barri... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=4837363 Mon, 16 May 2011 23:00:00 +0100 4837363 http://www.medworm.com/index.php?rid=4837362&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00811.x Marjolin ulcer is a well‐defined, but uncommon malignant ulcer that occurs in chronic wounds and cutaneous scars. Jean‐Nicolas Marjolin was credited with describing this phenomenon in 1828. This entity is frequently overlooked and therefore inadequately treated leading to a poor prognosis. The malignant transformation of an ulcer is most commonly associated with burn scars, but has been reported in many other types of chronic, non healing wounds such as traumatic wounds, venous stasis and chronic pressure ulcers, fistulas, lacerations and leprosy ulcers. Development of malignancy tends to be slow with an average time of approximately 25 years. Various theories concerning pathogenesis of Marjolin ulcer have been proposed. Well‐differentiated squamous cell carcinoma (SCC) is the most c... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=4837362 Mon, 16 May 2011 23:00:00 +0100 4837362 http://www.medworm.com/index.php?rid=4817914&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00806.x The aim of this study was to prove the effectiveness of MatriDerm® combined with skin grafting versus skin grafting alone in post‐traumatic wounds treatment. At the Department of Plastic and Reconstructive Surgery of the University of Rome Tor Vergata, we treated 60 patients: 30 patients with dermal substitutes (MatriDerm®) combined with autologous skin graft and 30 with skin graft alone. Two weeks after the first treatment, 95% of wounds treated with MatriDerm® and skin graft showed a re‐epithelisation, whereas it was 75–80% in the control group. We used the Manchester Scar Scale (MSS) and patient's self‐estimation scale to assess the outcomes. Mann–Whitney U test was performed for the five items of the MSS and the results were combined to those of patient's self‐estimation... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=4817914 Fri, 13 May 2011 16:36:42 +0100 4817914 http://www.medworm.com/index.php?rid=4810105&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00810.x (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=4810105 Thu, 12 May 2011 00:29:23 +0100 4810105 http://www.medworm.com/index.php?rid=4810104&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00778.x Only a few papers have been published about unusual localisations of pressure ulcer. To date, no papers were published presenting pressure ulcer on external genitals in women. The paper presents the mechanism of origin of vulval pressure ulcer, surgical treatment (excision of lesion tissue of the pressure ulcer) and reconstruction of the vulva. The patient, aged 50, has been paraplegic for 20 years. During the last 3 years she has had a wound which was spreading in the region of the vulva. The pressure ulcer was surgically removed, external female genitals were reconstructed using advancement skin flap and the function and natural appearance of organs were re‐established. The presence of all three aetiological factors for the formation of pressure ulcer – presence of prolonged pressure... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=4810104 Thu, 12 May 2011 00:29:21 +0100 4810104 http://www.medworm.com/index.php?rid=4810103&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00809.x (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=4810103 Thu, 12 May 2011 00:29:13 +0100 4810103 http://www.medworm.com/index.php?rid=4810102&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00807.x (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=4810102 Thu, 12 May 2011 00:29:12 +0100 4810102 http://www.medworm.com/index.php?rid=4817918&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00790.x Negative pressure wound therapy (NPWT) contracts the wound and alters the pressure in the tissue of the wound edge, which accelerates wound healing. The aim of this study was to examine the effect of the type (foam or gauze) and size (small or large) of wound filler for NPWT on wound contraction and tissue pressure. Negative pressures between −20 and −160 mmHg were applied to a peripheral porcine wound (n = 8). The pressure in the wound edge tissue was measured at distances of 0·1, 0·5, 1·0 and 2·0 cm from the wound edge and the wound diameter was determined. At 0·1 cm from the wound edge, the tissue pressure decreased when NPWT was applied, whereas at 0·5 cm it increased. Tissue pressure was not affected at 1·0 or 2·0 cm from the wound edge. The tissue pressure, at 0·5 cm fro... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=4817918 Wed, 11 May 2011 23:00:00 +0100 4817918 http://www.medworm.com/index.php?rid=4817917&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00798.x Negative pressure wound therapy (NPWT) is becoming routine for the preparation of wounds prior to grafting for wound closure. We have been using both foam‐ and gauze‐based NPWT to prepare wounds for closure prior to skin grafting and have obtained similar proportions of closed wounds; 7/7 for wounds treated with gauze‐based NPWT and 11/11 for wounds treated with foam‐based NPWT. In our follow‐up consultations we observed that skin grafts on the foam‐treated patients were less pliable than those on the gauze‐treated patients. To assess what the mechanism of this effect might be, we compared the specific details of the treatments of both 11 foam and 7 gauze patients, including depth, location, patients' age and co‐morbidity; biopsies of granulation and scar tissue were taken ... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=4817917 Wed, 11 May 2011 23:00:00 +0100 4817917 http://www.medworm.com/index.php?rid=4817916&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00801.x Many complementary and alternative products are used to treat wounds. The essential oil of Melaleuca alternifolia, tea tree oil, has proven antimicrobial and anti‐inflammatory properties, may be useful in methicillin‐resistant Staphylococcus aureus (MRSA) decolonisation regimens and is reputed to have ‘wound‐healing’ properties, but more data are required to support these indications. The primary aim of this uncontrolled case series was to assess whether a tea tree oil solution used in a wound cleansing procedure could decolonise MRSA from acute and chronic wounds of mixed aetiology. The secondary aim was to determine if the tea tree oil solution influenced wound healing outcomes. Nineteen participants with wounds suspected of being colonised with MRSA were enrolled in a pilot st... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=4817916 Wed, 11 May 2011 23:00:00 +0100 4817916 http://www.medworm.com/index.php?rid=4817915&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00802.x A 40‐year‐old female presented with history of swelling at the upper and middle of the left leg since 6 months was confirmed as post cancer surgery non healing wound not responding to conventional antibiotic therapy and local wound care in an operated case of synovial sarcoma of the knee, monophasic fibrous type with no lung metastasis. Post surgical non healing wound not responding to conventional therapy was treated successfully with local application of 3% citric acid ointment for 25 days. (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=4817915 Wed, 11 May 2011 23:00:00 +0100 4817915 http://www.medworm.com/index.php?rid=4701986&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00795.x The objective of this study is to develop a chitosan gel formulation containing liposomes loaded with epidermal growth factor (EGF) and to evaluate their effects on the healing of second‐degree burn wounds in rats by immunohistochemical, histochemical and histological methods. EGF‐containing multilamellar liposomes which were carried in chitosan gel, EGF gel and EGF‐loaded liposome formulations were prepared. The in vivo experiments were performed on female Sprague Dawley rats. Second‐degree standard burn wounds were formed on rats and liposomes containing 10 µg/ml EGF in 2% chitosan gel, EGF‐chitosan gel and EGF‐loaded liposome formulations were applied daily to the burn wounds and biopsies were taken at the 3rd, 7th and 14th day of the treatment. When the results were evalua... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=4701986 Mon, 11 Apr 2011 23:00:00 +0100 4701986 http://www.medworm.com/index.php?rid=4690774&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00774.x Wound dressings impregnated with silver have a role to play in aiding to reduce both the dressing and wound microbial bioburden. It is therefore imperative that antimicrobial wound dressings have efficacy on a broad range of clinical significant microorganisms. Accordingly, this study aimed to determine the antimicrobial efficacy of a silver alginate dressing against 115 wound isolates that had been isolated routinely from patients at West Virginia University Hospital. Standardised corrected zones of inhibition (CZOIs) were performed on all clinical isolates. It was found that the silver alginate dressing was able to inhibit the growth of all microorganisms tested. In particular, the silver alginate dressing inhibited the growth of Candida albicans and yeasts with CZOI of 3–11·5 mm. All... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=4690774 Wed, 06 Apr 2011 23:00:00 +0100 4690774 http://www.medworm.com/index.php?rid=4786469&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00796.x This study suggests that subjects with DFU may suffer from PDPN, but do not perceive it. Further studies are needed to assess if treatment of PDPN in these subjects is beneficial. (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=4786469 Thu, 31 Mar 2011 23:00:00 +0100 4786469 http://www.medworm.com/index.php?rid=4718056&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00788.x This report shows a successful treatment with laser phototherapy (LPT) on a delayed wound healing in oral mucosa previously submitted to radiotherapy with a follow up of 3 years. A 47‐year‐old patient treated 6 months earlier for tongue squamous cell carcinoma by surgery and radiotherapy presented with a mass in the operated area. Biopsy showed chronic inflammatory infiltrate around a residual polyglactin suture. After 2 months there was a painful mucosal dehiscence on the biopsy site. LPT was performed using a semiconductor laser with 660‐nm wavelength (InGaAlP) and spot size of 0·04 cm2. The parameters applied were 40 mW, 4 Jcm2/point, 0·16 J/point, 2·4 J/session. The irradiation was performed punctually, through contact mode in 15 points (4 seconds/point), on top of and around ... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=4718056 Thu, 31 Mar 2011 23:00:00 +0100 4718056 http://www.medworm.com/index.php?rid=4701985&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00799.x We present a case of AGEP following intravitreal injection of Ranibizumab, a monoclonal antibody vascular endothelial growth factor inhibitor. (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=4701985 Thu, 31 Mar 2011 23:00:00 +0100 4701985 http://www.medworm.com/index.php?rid=4690773&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00797.x This study included 24 patients with chronic diabetic ulcers. They were systematically randomised into two groups: PRP group (n = 12) and PPP group (n = 12). The results showed that healing in PRP group was significantly faster (P < 0·005). PRP enhances healing of chronic diabetic foot ulcers. (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=4690773 Thu, 31 Mar 2011 23:00:00 +0100 4690773 http://www.medworm.com/index.php?rid=4668304&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00781.x This study also demonstrated a statistical interaction between the lactoferrin/xylitol hydrogel and the silver wound dressing. (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=4668304 Thu, 31 Mar 2011 23:00:00 +0100 4668304 http://www.medworm.com/index.php?rid=4657008&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00785.x We report on six patients, one female and five males, aged between 32 and 89 years, and deep soft tissue defects with exposed tendons, cartilage or bone. The aetiology of these defects was vascular (n = 3), tumour surgery (2), and post‐traumatic (1). Wounds were treated with a collagen–elastin matrix applied above the exposed structures. In five patients, the procedure was combined with mesh graft transplantation in the same setting. Follow‐up varied between 12 and 40 weeks. Wound healing was uncomplicated in all transplanted patients until first dressing change after 7 days. All but one transplant showed a 100% take rate and the transplant was stable within 10–14 days. A complete wound closure was also achieved without transplantation, but this took 8 weeks. No adverse effects wer... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=4657008 Wed, 30 Mar 2011 23:24:14 +0100 4657008 http://www.medworm.com/index.php?rid=4657011&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00771.x The complex biological and physiological mechanisms that result in poor quality scarring are still not fully understood. This review looks at current evidence of the role of transforming growth factor‐beta (TGFβ) in this pathological process. (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=4657011 Tue, 29 Mar 2011 23:00:00 +0100 4657011 http://www.medworm.com/index.php?rid=4657010&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00786.x In conclusion, results with the new foam appear encouraging in ameliorating skin dryness in the diabetic foot and further investigation is warranted. (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=4657010 Tue, 29 Mar 2011 23:00:00 +0100 4657010 http://www.medworm.com/index.php?rid=4657009&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00787.x (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=4657009 Tue, 29 Mar 2011 23:00:00 +0100 4657009 http://www.medworm.com/index.php?rid=4598892&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00782.x The objective of this article is to describe our experience using the abdominal dressing vacuum‐assisted closure therapy in treatment of the open abdomen. Since December 2006, all patients requiring treatment with the open abdomen technique have been treated with the abdominal dressing system and vacuum‐assisted closure therapy (VAC® KCI, San Antonio, USA). The results obtained with this technique in non traumatic patients are analysed herein. The abdominal dressing system was used on 46 patients in the period between January 2006 and December 2009, with a mean 63 years old (29–80), with a gender distribution of 33 men (72%) and 13 women (28%). Closure of the abdominal wall was possible in 24 patients, 5 of which were primary in the recent postoperative phase, 5 had primary suture o... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=4598892 Wed, 16 Mar 2011 22:20:20 +0100 4598892 http://www.medworm.com/index.php?rid=4587803&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00792.x (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=4587803 Tue, 15 Mar 2011 19:00:48 +0100 4587803 http://www.medworm.com/index.php?rid=4587802&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00770.x The objective of the study was to investigate the use of a 1·3 times normal platelet concentration platelet‐rich plasma (PRP) gel to move chronic wounds towards healing in persons with spinal cord injury (SCI). The study design was a case series of 20 persons with SCI with non healing wounds. The outcome measures were, in wound area, volume, undermining and sinus tracts/tunnels (ST/Ts), calculated average, (i) percent of change from baseline, (ii) change per day from baseline, (iii) number of treatments and (iv) number of weeks. In a mean of 4·0, after treatments over 3·4 weeks, the wounds closed on an average of 47·9% in area and 56·0% in volume. Undermining closed on an average of 31·4% using 3·5 treatments over 2·6 weeks. ST/Ts closed on an average of 26·1% after 2·3 treatme... International Wound Journal journals http://www.medworm.com/rss/comments.php?id=4587802 Tue, 15 Mar 2011 19:00:46 +0100 4587802 http://www.medworm.com/index.php?rid=4587801&cid=s_32951_43_f&fid=32951&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1742-481X.2011.00794.x (Source: International Wound Journal) International Wound Journal journals http://www.medworm.com/rss/comments.php?id=4587801 Tue, 15 Mar 2011 19:00:41 +0100 4587801