MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Investigative Ophthalmology' source. Wed, 08 Feb 2012 23:31:40 +0100 http://www.medworm.com/index.php?rid=5650756&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F2%2F586%3Frss%3D1 (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650756 Wed, 01 Feb 2012 05:00:00 +0100 5650756 http://www.medworm.com/index.php?rid=5650755&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F2%2F574%3Frss%3D1 Conclusions. -Secretase, and in particular PS1 alone, are potent regulators of angiogenesis and this is due in part to stabilizing endogenous superoxide generation and reducing proinflammatory cytokine expression during CNV. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650755 Wed, 01 Feb 2012 05:00:00 +0100 5650755 http://www.medworm.com/index.php?rid=5650754&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F2%2F565%3Frss%3D1 Conclusions. Sildenafil accelerates the rate of AC refilling and might have beneficial utility as an agent enhancing fluid entry into the AC of patients who experienced AH loss during eye surgery, as well as in some cases of ocular hypotony. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650754 Wed, 01 Feb 2012 05:00:00 +0100 5650754 http://www.medworm.com/index.php?rid=5650753&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F2%2F560%3Frss%3D1 Conclusions. The reduced ocular blood flow in DBA/2J mice compared with C57BL/6 control mice suggests that ischemia or hypoxia should be considered as a possible contributing factor in the optic neuropathy in the DBA/2J mouse model of glaucoma. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650753 Wed, 01 Feb 2012 05:00:00 +0100 5650753 http://www.medworm.com/index.php?rid=5650752&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F2%2F551%3Frss%3D1 Conclusions. These studies indicate that Epha2 is not required for transparency but does play an indispensable role in the cytoarchitecture and refractive quality of the lens. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650752 Wed, 01 Feb 2012 05:00:00 +0100 5650752 http://www.medworm.com/index.php?rid=5650751&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F2%2F543%3Frss%3D1 Conclusions. Variations in refractive error in adults aged 50+ years were mostly influenced by variations in axial length and in crystalline lens refractive power, followed by variations in corneal refractive power, and, to a minor degree, by variations in lens thickness and anterior chamber depth. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650751 Wed, 01 Feb 2012 05:00:00 +0100 5650751 http://www.medworm.com/index.php?rid=5650834&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F538%3Frss%3D1 Conclusions. These results suggest that a STAT3 genetic polymorphism is associated with the susceptibility to BD. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650834 Tue, 31 Jan 2012 05:00:00 +0100 5650834 http://www.medworm.com/index.php?rid=5650833&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F532%3Frss%3D1 Conclusions. In truncating BEST1 mutations, the null phenotype associated with ARB is attributed to a substantial decrease of BEST1 expression promoted by the nonsense-mediated decay (NMD) surveillance mechanism. Moreover, the severity of the phenotype increases with the preserved amount of altered transcript, suggesting that the clinical outcome reflects the combined null and dominant negative effects of the two mutations over the patient's genetic background. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650833 Tue, 31 Jan 2012 05:00:00 +0100 5650833 http://www.medworm.com/index.php?rid=5650832&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F525%3Frss%3D1 Conclusions. Noninvasive techniques of tear film surface assessment have the potential to discriminate contact lens type/material on eye. LSI was found to more effectively perform this discrimination than the dynamic area HSV technique. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650832 Tue, 31 Jan 2012 05:00:00 +0100 5650832 http://www.medworm.com/index.php?rid=5650831&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F521%3Frss%3D1 Conclusions. All methods proved equally efficient in producing UT grafts, but stromal hydration induced tissue structural changes. EC loss was unaffected by the additional manipulation required to prepare UT grafts. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650831 Tue, 31 Jan 2012 05:00:00 +0100 5650831 http://www.medworm.com/index.php?rid=5650830&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F513%3Frss%3D1 Conclusions. The expression of putative stem cell markers (CD90, ABCG2, and p63) and cytokeratins (CK12 and CK76) supports the hypothesis that ADS cells have self-renewal capacity and intrinsic plasticity that enables them to acquire some epithelial-like characteristics. Therefore, adult ADS cells could be a potential source for cell therapy in ocular surface regeneration. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650830 Tue, 31 Jan 2012 05:00:00 +0100 5650830 http://www.medworm.com/index.php?rid=5650829&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F508%3Frss%3D1 Conclusions. These findings support the notion that the haploinsufficiency of C9, a terminal complement complex component, engenders reduced intraocular secretion of VEGF and decreased risk for CNV development. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650829 Tue, 31 Jan 2012 05:00:00 +0100 5650829 http://www.medworm.com/index.php?rid=5650828&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F501%3Frss%3D1 Conclusions. Expression of the human RHO P23H transgene in the retina creates a miniature swine model with an inheritance pattern and retinal function that mimics adRP. This large-animal model can serve as a novel tool for the study of the pathogenesis and therapeutic intervention in the most common form of adRP. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650828 Tue, 31 Jan 2012 05:00:00 +0100 5650828 http://www.medworm.com/index.php?rid=5650827&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F490%3Frss%3D1 Conclusions. A novel shooter instrument design allows for safe and atraumatic transvitreal delivery of hydrogel-encapsulated, ultrathin, rigid-elastic carriers into the subretinal space. The procedure may be used in the future to deliver cultured RPE. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650827 Tue, 31 Jan 2012 05:00:00 +0100 5650827 http://www.medworm.com/index.php?rid=5650826&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F483%3Frss%3D1 Conclusions. A two-dimensional (2-D) spatial NFB map of the retina can be developed using structure-structure relationships from SD-OCT. Such SD-OCT-based NFB maps may enhance glaucoma detection and contribute to monitoring change in the future. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650826 Tue, 31 Jan 2012 05:00:00 +0100 5650826 http://www.medworm.com/index.php?rid=5650825&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F475%3Frss%3D1 Conclusions. It is reasonable that tear film stability is higher in infants than in adults. Their meibum contains less CH3 and CC groups and higher levels of protein, and as a result, the lipid is more ordered because of the tighter and stronger lipid–lipid interactions. For water to evaporate, it must first pass through the tight lipid–lipid barrier. For tears to break up, lipid–lipid interactions must be broken. It is reasonable that because the lipid–lipid interactions are stronger in infants' and children's tears compared with those of adolescents and adults, the tear film in the younger groups is more stable and provides a better barrier to evaporation than does the tear film of adults. Lipid saturation could be the critical feature in meibum that stabilizes te... Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650825 Tue, 31 Jan 2012 05:00:00 +0100 5650825 http://www.medworm.com/index.php?rid=5650824&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F470%3Frss%3D1 Conclusions. Higher blood pressure in children is associated with smaller retinal Df, reflecting rarefaction of the retinal microvasculature. Retinal fractal analysis detects early subtle microvascular effects of elevated blood pressure, and may further the understanding of the genesis of ocular and systemic vascular complications of hypertension. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650824 Tue, 31 Jan 2012 05:00:00 +0100 5650824 http://www.medworm.com/index.php?rid=5650823&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F461%3Frss%3D1 Conclusions. ADAMTSL4 is a secreted glycoprotein that is widely distributed in the human eye. Enhanced fibrillin-1 deposition in the presence of ADAMTSL4 and colocalization of ADAMTSL4 with fibrillin-1 in the ECM of cultured fibroblasts suggest a potential role for ADAMTSL4 in the formation or maintenance of the zonule. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650823 Tue, 31 Jan 2012 05:00:00 +0100 5650823 http://www.medworm.com/index.php?rid=5650822&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F454%3Frss%3D1 Conclusions. The effect of cryptochrome loss on nonvisual photoreception is due to loss of the circadian clock nonspecifically. The circadian clock modulates the sensitivity of nonvisual photoreception. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650822 Wed, 25 Jan 2012 05:00:00 +0100 5650822 http://www.medworm.com/index.php?rid=5650821&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F448%3Frss%3D1 Conclusions. Traversal of multilayered corneal epithelia in vitro by cytotoxic P. aeruginosa requires ExoU with an active phospholipase domain. Correlative loss of TER with traversal by wild-type, or exoU-complemented, bacteria suggests involvement of epithelial cell death and/or lost tight junction integrity. However, traversal by exoU mutants without reduced TER suggests that additional mechanisms are also operative. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650821 Wed, 25 Jan 2012 05:00:00 +0100 5650821 http://www.medworm.com/index.php?rid=5650820&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F440%3Frss%3D1 Conclusions. The novel association of SERPINI2 with refractive error and myopia is suggestive of a possible link between physiological pathways controlling eye growth and development and those controlling glucose metabolism. The findings indicate that SERPINI2 is a promising candidate for further investigations of the genetic susceptibility to myopia. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650820 Wed, 25 Jan 2012 05:00:00 +0100 5650820 http://www.medworm.com/index.php?rid=5650819&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F434%3Frss%3D1 Conclusions. The National Spectacle Program has not produced uniform improvement across all service indicators. Evidence-based enhancements may now be initiated. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650819 Wed, 25 Jan 2012 05:00:00 +0100 5650819 http://www.medworm.com/index.php?rid=5650818&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F429%3Frss%3D1 Conclusions. The air pollutants NO2, SO2, O3, and PM10 increase the chances of outpatient visits for nonspecific conjunctivitis and have no evident lag effects. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650818 Wed, 25 Jan 2012 05:00:00 +0100 5650818 http://www.medworm.com/index.php?rid=5650817&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F421%3Frss%3D1 Conclusions. High ambient lighting retards the development of form-deprivation myopia in monkeys. These results are in agreement with the hypothesis that the protective effects of outdoor activities against myopia in children are due to exposure to the higher light levels encountered outdoors. It is possible that therapeutic protection against myopia can be achieved by manipulating indoor lighting levels. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650817 Wed, 25 Jan 2012 05:00:00 +0100 5650817 http://www.medworm.com/index.php?rid=5650816&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F413%3Frss%3D1 Conclusions. This study has demonstrated that Raman microscopy can discriminate between major retinal biomolecules, thus providing an unbiased account of how their composition varies due to the impact of the MPDZ null mutation in the rdd chick relative to expression in the normal wt retina. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650816 Wed, 25 Jan 2012 05:00:00 +0100 5650816 http://www.medworm.com/index.php?rid=5650815&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F406%3Frss%3D1 Conclusions. RTL342M suppressed clinical and histologic signs of EAE/ON by preventing the recruitment of inflammatory cells into the optic nerve and showed neuroprotective effects against ON. However, to achieve full therapeutic benefit, more doses may be needed. These findings suggest a possible clinical application of this novel class of T-cell-tolerizing drugs for patients with optic neuritis. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650815 Wed, 25 Jan 2012 05:00:00 +0100 5650815 http://www.medworm.com/index.php?rid=5650814&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F394%3Frss%3D1 Conclusions. ALCS and PLCS visibility within control and EG NHP ONHs increased in EDI compared to conventional SD-OCT data sets. Further study of EDI effects on PLCS parameterization is required. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650814 Wed, 25 Jan 2012 05:00:00 +0100 5650814 http://www.medworm.com/index.php?rid=5650813&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F387%3Frss%3D1 Conclusions. Only the monocular threshold increases with background complexity. The binocular summation increases with background complexity in the periphery. When the background becomes more complex and the monocular visual processing reaches its limit, binocular interaction functions efficiently. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650813 Wed, 25 Jan 2012 05:00:00 +0100 5650813 http://www.medworm.com/index.php?rid=5650812&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F379%3Frss%3D1 Conclusions. The Tat-PTEN fusion proteins were successfully transduced into the SCF cells and induced the suppression of transdifferentiation and fibrosis through the regulation of TGF-β–mediated signaling. The ability of the Tat-PTEN fusion protein to regulate cell survival could potentially be applied to protein therapy to counteract postoperative scarring in glaucoma surgery. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650812 Wed, 25 Jan 2012 05:00:00 +0100 5650812 http://www.medworm.com/index.php?rid=5650811&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F374%3Frss%3D1 Conclusions. In conclusion, the data of the present study suggest that nifedipine augments the ChBF response to an experimental increase in OPP. In addition, it confirms that the choroidal vasculature has a significant regulatory capacity over wide ranges of OPPs during isometric exercise. (ClinicalTrials.gov number, NCT00280462.) (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650811 Wed, 25 Jan 2012 05:00:00 +0100 5650811 http://www.medworm.com/index.php?rid=5650810&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F361%3Frss%3D1 Conclusions. These findings suggest that xlProminin-1 may serve as an anti–fusogenic factor in the regulation of disk morphogenesis and may help to maintain the open lamellar structure of basal ROS and COS disks in X. laevis photoreceptors. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650810 Wed, 25 Jan 2012 05:00:00 +0100 5650810 http://www.medworm.com/index.php?rid=5650809&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F354%3Frss%3D1 Conclusions. The nitinol clip prototype is well tolerated and showed no evidence of toxicity in the short-term. The injectable delivery system was faster and technically less challenging than conventional suture techniques. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650809 Wed, 25 Jan 2012 05:00:00 +0100 5650809 http://www.medworm.com/index.php?rid=5650808&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F348%3Frss%3D1 Conclusions. The single-base-pair substitution in the seed region of miR-184 is responsible for the disease phenotype observed in EDICT syndrome. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650808 Wed, 25 Jan 2012 05:00:00 +0100 5650808 http://www.medworm.com/index.php?rid=5650807&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F337%3Frss%3D1 Conclusions. Loss of the terpenoids could be deleterious to meibum since they exhibit a plethora of mostly positive biological functions and could account for the lower level of cholesterol esters observed in Md compared with Mn. All three changes could account for the higher degree of lipid order of Md compared with age-matched Mn. In addition to the power of NMR spectroscopy to detect differences in the composition of meibum, it is promising that NMR can be used as a diagnostic tool. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650807 Wed, 25 Jan 2012 05:00:00 +0100 5650807 http://www.medworm.com/index.php?rid=5650806&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F322%3Frss%3D1 Conclusions. The DIGE procedure revealed new proteins whose abundance is altered during myopia development and recovery. Many of these are involved in cell-matrix adhesions, cytoskeleton, and transcriptional regulation and extend our understanding of the remodeling that controls the extensibility of the sclera. Reductions in these proteins during minus lens wear may produce the increased scleral viscoelasticity that results in faster axial elongation. Recovery is not a mirror image of lens-induced myopia—many protein levels, decreased during LIM, returned to normal, or slightly above normal, and additional cytoskeleton proteins were upregulated. However, no single protein or pathway appeared to be responsible for the scleral changes during myopia development or recovery. (Source: Inv... Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650806 Wed, 25 Jan 2012 05:00:00 +0100 5650806 http://www.medworm.com/index.php?rid=5650805&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F316%3Frss%3D1 Conclusions. Interocular spatial correspondence of abnormal mfERG responses exists in adolescents with type 1 diabetes and no retinopathy. This is most apparent for IT abnormalities. This correspondence could be used in clinical trials, and raises the possibility of initiating treatment in both eyes at early disease stages as new topical treatments emerge. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650805 Wed, 25 Jan 2012 05:00:00 +0100 5650805 http://www.medworm.com/index.php?rid=5650804&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F309%3Frss%3D1 Conclusions. The findings suggest that confocal red-free imaging is a simple, reliable, safe, and noninvasive method for effectively imaging the FAZ. This procedure has the potential to be used for the noninvasive detection and quantification of FAZ in screening, initial evaluation, and follow-up observation of progressive ischemic retinopathies such as DR and RVO. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650804 Wed, 25 Jan 2012 05:00:00 +0100 5650804 http://www.medworm.com/index.php?rid=5650803&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F301%3Frss%3D1 Conclusions. Neither low tear levels nor ovarian hormones contribute to spontaneous keratitis in B10.TCR–/– female mice, nor does it appear to depend on an infectious agent carried vertically in this strain. However, αβ T cells from keratitic hosts are sufficient to induce disease in the resistant B10.TCRβ–/––/– strain. Autoaggressive αβ T cells in the absence of V1+ T cells in B10.TCR–/– mice may be insufficiently checked to prevent disease. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650803 Wed, 25 Jan 2012 05:00:00 +0100 5650803 http://www.medworm.com/index.php?rid=5650802&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F294%3Frss%3D1 Conclusions. Intraocular anti NF-M IgM autoantibodies occur with high prevalence in vitreous of spontaneous autoimmune uveitis cases. The IgM dominated response may indicate a thymus-independent response to NF-M and merits further investigation in ERU, as well as in its human counterpart, autoimmune uveitis. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650802 Wed, 25 Jan 2012 05:00:00 +0100 5650802 http://www.medworm.com/index.php?rid=5650801&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F287%3Frss%3D1 Conclusions. These findings showed that contrast sensitivity is impaired in patients with NF1, associating for the first time abnormal low-level vision to the cognitive profile of this disorder. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650801 Wed, 25 Jan 2012 05:00:00 +0100 5650801 http://www.medworm.com/index.php?rid=5650800&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F279%3Frss%3D1 Conclusions. Limbal stromal niche cells expressing SC markers can be isolated and expanded to prevent differentiation and maintain clonal growth of limbal epithelial progenitors. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650800 Wed, 25 Jan 2012 05:00:00 +0100 5650800 http://www.medworm.com/index.php?rid=5650799&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F273%3Frss%3D1 Conclusions. Inversely related HCEnC expression levels of ZEB1 and COL4A3 in PPCD3 indicate that ZEB1-mediated alterations in COL4A3 expression are most likely associated with the pathogenesis of this corneal endothelial dystrophy. However, the demonstration of COL4A3 expression in healthy adult primary HCEnCs suggests that PPCD3 is more likely to involve an alteration in the timing and/or degree of COL4A3 expression than to result from the dichotomous change implied by the previously proposed ectopic expression model. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650799 Wed, 25 Jan 2012 05:00:00 +0100 5650799 http://www.medworm.com/index.php?rid=5650798&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F267%3Frss%3D1 Conclusions. Although P. aeruginosa corneal ulcers have a more severe presentation, they appear to respond better to treatment than other bacterial ulcers. The authors did not find a significant benefit with corticosteroid treatment, but they also did not find any increase in adverse events. (ClinicalTrials.gov number, NCT00324168.) (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650798 Wed, 25 Jan 2012 05:00:00 +0100 5650798 http://www.medworm.com/index.php?rid=5650797&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F261%3Frss%3D1 Conclusions. There is significant diurnal variation of CT, with good intervisit reproducibility of diurnal patterns on two different days. The amplitude of variation varies with morning baseline CT, and is correlated with age, axial length, refractive error, and change in systolic blood pressure. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650797 Wed, 25 Jan 2012 05:00:00 +0100 5650797 http://www.medworm.com/index.php?rid=5650796&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F253%3Frss%3D1 Conclusions. Improvements in mfPOP contraction amplitudes and time to peak responses were measured in eyes treated with intravitreal ranibizumab; however, response delays appeared to be the most indicative of functional improvement. Confirmation of hypersensitivity in the extrafoveal field in a larger group may support this finding as a prognostic marker for good treatment outcomes. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650796 Wed, 25 Jan 2012 05:00:00 +0100 5650796 http://www.medworm.com/index.php?rid=5650795&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F248%3Frss%3D1 Conclusions. The PF is an objective relative measure of protective properties. The Grx1 gene is associated with an in vivo PF of 1.3. This result signifies that the presence of the gene allows a 1.3 times longer in vivo exposure to UVR, at equivalent irradiance, than the absence of the gene before early-onset, UVR-induced cataract occurs. This finding indicates the important role of the Grx1 gene in the oxidation defense system of the lens. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650795 Wed, 25 Jan 2012 05:00:00 +0100 5650795 http://www.medworm.com/index.php?rid=5650794&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F241%3Frss%3D1 Conclusions. Cytokine networks including TGF-β1, IL-8, and SAA in aqueous humor may have critical roles in IOP elevations in patients with open-angle glaucoma. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650794 Wed, 25 Jan 2012 05:00:00 +0100 5650794 http://www.medworm.com/index.php?rid=5650793&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F235%3Frss%3D1 Conclusions. Basing treatment decisions after mass azithromycin distributions on the WHO simplified grading system will maximize the treatment of infected persons compared with a DNA-based test but will also result in more uninfected persons being treated. The RNA-based test was considerably more sensitive, and almost equivalently specific, compared with a DNA-based test. (ClinicalTrials.gov number, NCT00322972.) (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650793 Wed, 25 Jan 2012 05:00:00 +0100 5650793 http://www.medworm.com/index.php?rid=5650792&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F228%3Frss%3D1 Conclusions. A lack of opticin does not influence vascular development, but opticin is antiangiogenic and inhibits preretinal neovascularization. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650792 Wed, 25 Jan 2012 05:00:00 +0100 5650792 http://www.medworm.com/index.php?rid=5650791&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F224%3Frss%3D1 Conclusions. Eyes that develop POAG have significantly worse MDRs than eyes that do not. Eyes that reached endpoints due to both VF and optic disc change had worse MDRs than eyes displaying change in only one of these. MDR was not significantly associated with randomization, suggesting that MDR may not be the best measure of VF change in early-stage POAG. (ClinicalTrials.gov number, NCT00000125.) (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650791 Wed, 25 Jan 2012 05:00:00 +0100 5650791 http://www.medworm.com/index.php?rid=5650790&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F215%3Frss%3D1 Conclusions. By applying full-field calibrations, relative accommodation in pharmacologically stimulated monkeys was found to be similar to that reported with voluntary accommodation in humans. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650790 Fri, 20 Jan 2012 05:00:00 +0100 5650790 http://www.medworm.com/index.php?rid=5650789&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F205%3Frss%3D1 Conclusions. Given that amplitude and frequency have separable effects on percept size, these findings suggest that frequency modulation improves the encoding of a wide range of brightness levels without a loss of spatial resolution. Future retinal prosthesis designs could benefit from having the flexibility to manipulate pulse train amplitude and frequency independently (clinicaltrials.gov number, NCT00279500). (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650789 Fri, 20 Jan 2012 05:00:00 +0100 5650789 http://www.medworm.com/index.php?rid=5650788&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F198%3Frss%3D1 Conclusions. This method provides measurable 3D images of the LC that enable comprehensive evaluation of the LC configuration. This technique should facilitate the investigation of the LC in glaucomatous eyes. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650788 Fri, 20 Jan 2012 05:00:00 +0100 5650788 http://www.medworm.com/index.php?rid=5650787&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F191%3Frss%3D1 Conclusions. Topical application of EGF presented clinical improvements on dry eye by stabilizing the tear film and maintaining the integrity of epithelium. The results indicate that EGF has potential as a therapeutic agent in clinical treatment of dry eye. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650787 Fri, 20 Jan 2012 05:00:00 +0100 5650787 http://www.medworm.com/index.php?rid=5650786&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F185%3Frss%3D1 Conclusions. Brillouin imaging can assess the biomechanical properties of cornea in situ with high spatial resolution. This novel technique has the potential for use in clinical diagnostics and treatment monitoring. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650786 Fri, 20 Jan 2012 05:00:00 +0100 5650786 http://www.medworm.com/index.php?rid=5650785&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F179%3Frss%3D1 Conclusions. In subjects with resolved CSC, FAF gray values correlated with visual function. BCVA correlated most strongly with SW-M350. MP at 2° and at 4° correlated most strongly with SW-SD350. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650785 Fri, 20 Jan 2012 05:00:00 +0100 5650785 http://www.medworm.com/index.php?rid=5650784&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F171%3Frss%3D1 Conclusions. The particles moving in the capillaries are suggested to be reflections of photoreceptor aggregates that pass through circulating transparent objects such as leukocytes or plasma gaps. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650784 Fri, 20 Jan 2012 05:00:00 +0100 5650784 http://www.medworm.com/index.php?rid=5650783&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F164%3Frss%3D1 Conclusions. Automated classification of PEDs using internal reflectivity characteristics appears to be sensitive for detecting serous and fibrovascular PEDs. Automated classification and quantification of PEDs may be a useful tool in future studies for stratifying PEDs according to risk and possibly predicting the risk of advanced AMD. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650783 Fri, 20 Jan 2012 05:00:00 +0100 5650783 http://www.medworm.com/index.php?rid=5650782&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F157%3Frss%3D1 Conclusions. In summary, it is shown here for the first time that OCT can reliably monitor neurodegeneration in an experimental model of autoimmune optic neuritis in rodents. Moreover, in comparing RNFL thickness decline with histopathological analyses of the optic nerve, these results suggest an early, and in part, inflammation-independent process of RNFL degeneration in autoimmune optic neuritis. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650782 Fri, 20 Jan 2012 05:00:00 +0100 5650782 http://www.medworm.com/index.php?rid=5650781&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F152%3Frss%3D1 Conclusions. The present findings suggest that the phospholipase A2 activity found in pig AH under acidic conditions is due to LPLA2 and that it originates from ocular tissues surrounding the anterior chamber as well as plasma. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650781 Fri, 20 Jan 2012 05:00:00 +0100 5650781 http://www.medworm.com/index.php?rid=5650780&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F150%3Frss%3D1 (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650780 Tue, 17 Jan 2012 05:00:00 +0100 5650780 http://www.medworm.com/index.php?rid=5650779&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F143%3Frss%3D1 Conclusions. These data from a relatively small but broad sampling of age and clinical status suggest that clinically normal young infants and children with low amounts of hyperopia have similar lags of accommodation from the first few months after birth. Subjects with greater than 4 D of hyperopia, or amblyopia or strabismus, have more variable lags and therefore evidence of abnormal visual experience. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650779 Tue, 17 Jan 2012 05:00:00 +0100 5650779 http://www.medworm.com/index.php?rid=5650778&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F136%3Frss%3D1 Conclusions. This study suggests that CAP amplitude reflects both axonal and myelin integrity and RA is an optimal parameter for functional assessment compared with axial or radial diffusivity alone in murine optic nerves after retinal ischemia. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650778 Tue, 17 Jan 2012 05:00:00 +0100 5650778 http://www.medworm.com/index.php?rid=5650777&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F126%3Frss%3D1 Conclusions. It was found that EMT is induced during repair of the lacrimal gland to generate MSCs to initiate repair, and that mesenchymal–epithelial transition is then activated to form acinar and ductal epithelial cells. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650777 Tue, 17 Jan 2012 05:00:00 +0100 5650777 http://www.medworm.com/index.php?rid=5650776&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F120%3Frss%3D1 Conclusions. The authors have described useful baseline anterior segment parameters from this population-based study of ethnic South Indian adults. These data may be useful for corneal and anterior segment procedures such as endothelial keratoplasty and anterior chamber intraocular lens insertion. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650776 Tue, 17 Jan 2012 05:00:00 +0100 5650776 http://www.medworm.com/index.php?rid=5650775&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F119%3Frss%3D1 (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650775 Tue, 10 Jan 2012 05:00:00 +0100 5650775 http://www.medworm.com/index.php?rid=5650774&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F118%3Frss%3D1 (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650774 Tue, 10 Jan 2012 05:00:00 +0100 5650774 http://www.medworm.com/index.php?rid=5650773&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F117%3Frss%3D1 (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650773 Tue, 10 Jan 2012 05:00:00 +0100 5650773 http://www.medworm.com/index.php?rid=5650772&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F112%3Frss%3D1 Conclusions. Although aging can significantly delay the phase timing of the 24-hour IOP pattern toward the diurnal/awake period, it may not affect the postural IOP effect during the diurnal and the nocturnal periods. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650772 Tue, 10 Jan 2012 05:00:00 +0100 5650772 http://www.medworm.com/index.php?rid=5650771&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F107%3Frss%3D1 Conclusions. Additive genetic effects appear to explain most of the variance in peripheral refraction and relative peripheral refraction when adjusting for the effects of axial refraction. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650771 Tue, 10 Jan 2012 05:00:00 +0100 5650771 http://www.medworm.com/index.php?rid=5650770&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F100%3Frss%3D1 Conclusions. TUDCA treatment preserved ERG b-waves and the outer nuclear layer in Bbs1M390R/M390R mice, and prevented obesity assessed at P120. TUDCA treatment preserved ERG b-waves and the outer nuclear layer in the rd10 mice to P30. TUDCA is a prime candidate for treatment of humans with retinal degeneration, especially those with Bardet-Biedl syndrome, whom it may help not only with the vision loss, but with the debilitating obesity as well. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650770 Thu, 05 Jan 2012 05:00:00 +0100 5650770 http://www.medworm.com/index.php?rid=5650769&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F93%3Frss%3D1 Conclusions. Intact IGFBP-3 modulates Müller cell tractional force generation stimulated by IGF-I and IGF-II while the effects of the vitreous-type fragment are limited to IGF-II. Porcine Müller cells proliferate in response to PDGF, but not IGF-I or IGF-II. Both forms of IGFBP-3 are also without mitogenic effects alone or in combination with IGFs. It appears that Müller cell tractional force generation in PDR is driven by vitreous IGF activity and proliferation is stimulated by growth factors outside of the IGF system. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650769 Thu, 05 Jan 2012 05:00:00 +0100 5650769 http://www.medworm.com/index.php?rid=5650768&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F85%3Frss%3D1 Conclusions. The high-speed pvOCT allows contrast agent–free visualization of capillary networks in the human foveal region that is analogous to fundus FA imaging. This could allow for noninvasive diagnosis and progression monitoring of diabetic retinopathy in clinical settings. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650768 Thu, 05 Jan 2012 05:00:00 +0100 5650768 http://www.medworm.com/index.php?rid=5650767&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F76%3Frss%3D1 Conclusions. These results provide genetic evidence in mice that both EphB/ephrin-B forward and reverse signaling feed into an endogenous pathway to moderate the effects of glaucomatous insult on RGC axons. LIOH-induced axon loss is maintained in retina/optic nerve explants after removal from an ocular hypertensive environment. Exogenous application of EphB2 protein enhances RGC axon survival in explants, suggesting that modulation of Eph/ephrin signaling may be of therapeutic interest. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650767 Thu, 05 Jan 2012 05:00:00 +0100 5650767 http://www.medworm.com/index.php?rid=5650766&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F68%3Frss%3D1 Conclusions. Three months of bilateral sustained IGF-1 release in infant non-human primate MR resulted in increased muscle size and innervation density, mirrored in the untreated antagonist LR. It appears that bilateral MR treatment resulted in slow adaptation of both treated MR and contralateral LR muscles over time such that functional homeostasis and near-normal alignment were maintained. Further work is needed to determine what signaling mechanisms maintain proportional innervation when EOMs are forced to adapt to an externally applied perturbation. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650766 Thu, 05 Jan 2012 05:00:00 +0100 5650766 http://www.medworm.com/index.php?rid=5650765&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F62%3Frss%3D1 Conclusions. Elevated serum levels of DJ-1 are associated with choroidal nevi transformation risk factors. Therefore, DJ-1 appears to be a promising factor for predicting the growth of choroidal nevi and may be a potential biomarker of malignancy. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650765 Thu, 05 Jan 2012 05:00:00 +0100 5650765 http://www.medworm.com/index.php?rid=5650764&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F53%3Frss%3D1 Conclusions. The automatic algorithm accurately and reproducibly segmented three retinal boundaries in images containing drusen and GA. This automatic approach can reduce time and labor costs and yield objective measurements that potentially reveal quantitative RPE changes in longitudinal clinical AMD studies. (ClinicalTrials.gov number, NCT00734487.) (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650764 Thu, 05 Jan 2012 05:00:00 +0100 5650764 http://www.medworm.com/index.php?rid=5650763&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F47%3Frss%3D1 Conclusions. Retinal sensitivity to static and kinetic stimuli correlates better with outer than with overall retinal thickness. The hyperautofluorescent ring in FAF represents a transition zone from relatively well-preserved to abnormal retinal morphology and function, rendering FAF imaging a clinically significant tool for assessing the severity and progression of dysfunction in RP patients. Accurate coregistration of different modalities drastically increases the power of structure-function correlation studies and allows consistent associations to be drawn. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650763 Tue, 03 Jan 2012 05:00:00 +0100 5650763 http://www.medworm.com/index.php?rid=5650762&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F42%3Frss%3D1 Conclusions. Endoscopically guided puncture of retinal microvessels is feasible and can be performed through a pars plana entry without additional micromanipulation devices. This novel technique may be a safe and effective approach to catheter-directed endovascular thrombolysis in retinal vascular occlusive diseases. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650762 Tue, 03 Jan 2012 05:00:00 +0100 5650762 http://www.medworm.com/index.php?rid=5650761&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F37%3Frss%3D1 Conclusions. In eyes with neovascular AMD treated with intravitreal ranibizumab, larger baseline retinal venular caliber was significantly associated with a poorer response to treatment, possibly reflecting increased disease severity. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650761 Tue, 03 Jan 2012 05:00:00 +0100 5650761 http://www.medworm.com/index.php?rid=5650760&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F30%3Frss%3D1 Conclusions. Endothelium-dependent NO-mediated dilation of retinal arterioles is impaired by 90 minutes of ischemia induced by elevated IOP. The inhibitory effect appears to be mediated by the alteration of NO signaling via vascular superoxide. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650760 Tue, 03 Jan 2012 05:00:00 +0100 5650760 http://www.medworm.com/index.php?rid=5650759&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F23%3Frss%3D1 Conclusions. The authors have developed a fully human in vitro capsular bag system that relates well to clinical observations and permits the testing of novel intraocular lenses. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650759 Tue, 03 Jan 2012 05:00:00 +0100 5650759 http://www.medworm.com/index.php?rid=5650758&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F7%3Frss%3D1 Conclusions. RA regulation of pitx2 is essential for coordinating interactions among neural crest, mesoderm, and developing eye. The marked evolutionary conservation of Pitx2 function in eye and craniofacial development makes zebrafish a potentially powerful model of ARS, amenable to in vivo experimentation and development of potential therapies. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650758 Tue, 03 Jan 2012 05:00:00 +0100 5650758 http://www.medworm.com/index.php?rid=5650757&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F53%2F1%2F1%3Frss%3D1 Conclusions. The presence of at least four ophthalmoscopic signs (with the sign "swelling" included) gives the highest accuracy. Furthermore, peripapillary retinal folds seem to be related exclusively to ODE because they were never observed in our PODE group. These data may be useful for clinicians when evaluating patients referred for presumed optic disc edema in the acute phase. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5650757 Tue, 03 Jan 2012 05:00:00 +0100 5650757 http://www.medworm.com/index.php?rid=5553594&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9728%3Frss%3D1 Conclusions. P23H-hRho-GFP mice provide a valuable tool for evaluating the efficacy of potential therapies for ADRP that influence the levels or localization of P23H-rhodopsin. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553594 Wed, 28 Dec 2011 05:00:00 +0100 5553594 http://www.medworm.com/index.php?rid=5553593&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9721%3Frss%3D1 Conclusions. The addition of high molecular components to a base oil increases its extensional and shear viscosity. Although the extensional viscosity affected the ease with which the oil could be injected, the results showed that it was the shear viscosity that determined the relative velocity between the oil and the wall of the vitreous cavity, and thus the propensity to emulsify. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553593 Wed, 28 Dec 2011 05:00:00 +0100 5553593 http://www.medworm.com/index.php?rid=5553592&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9710%3Frss%3D1 Conclusions. These findings indicate that the murine model in which both the PPA and the ECA are ligated may be useful to clarify the pathologic mechanisms of retinal ischemic diseases and to evaluate neuroprotective drugs that target retinal ischemic injury. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553592 Wed, 28 Dec 2011 05:00:00 +0100 5553592 http://www.medworm.com/index.php?rid=5553591&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9703%3Frss%3D1 Conclusions. Although present, the intensity of this ISe band is lower in patients with diminished cone function than it is in healthy controls. This is consistent with the hypothesis that both rod and cone receptors must be absent or damaged for the ISe band to be missing. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553591 Wed, 28 Dec 2011 05:00:00 +0100 5553591 http://www.medworm.com/index.php?rid=5553590&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9694%3Frss%3D1 Conclusions. Rbpms can reliably be used as an RGC marker for quantitative evaluation in rat models of RGC degeneration, regardless of the nature and the location of the primary site of the injury and the extent of neurodegeneration. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553590 Wed, 28 Dec 2011 05:00:00 +0100 5553590 http://www.medworm.com/index.php?rid=5553589&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9684%3Frss%3D1 Conclusions. Circumferential scleral fibers may act as reinforcing rings to limit corneal and optic nerve head deformations, whereas equatorial meridional fibers may either provide resistance against extraocular muscle forces or limit globe axial elongation. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553589 Wed, 28 Dec 2011 05:00:00 +0100 5553589 http://www.medworm.com/index.php?rid=5553588&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9674%3Frss%3D1 Conclusions. Although test-retest variability is an important determinant in progression analysis, TA generally outperformed EA for the detection of RNFL progression in glaucoma. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553588 Wed, 28 Dec 2011 05:00:00 +0100 5553588 http://www.medworm.com/index.php?rid=5553587&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9665%3Frss%3D1 Conclusions. The patterns of disease expression in the MAK form of arRP showed some resemblance to patterns described in autosomal dominant RP, especially the form caused by RP1 mutations. The similarity in phenotypes is of interest, considering that there is experimental evidence of interaction between Mak and RP1 in the photoreceptor cilium. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553587 Wed, 28 Dec 2011 05:00:00 +0100 5553587 http://www.medworm.com/index.php?rid=5553586&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9658%3Frss%3D1 Conclusions. NCR, Retinomax, and SureSight had similar and high accuracy in detecting vision disorders in preschoolers across all types of screeners and age of child, consistent with previously reported results at specificity levels of 90% and 94%. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553586 Wed, 28 Dec 2011 05:00:00 +0100 5553586 http://www.medworm.com/index.php?rid=5553585&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9651%3Frss%3D1 Conclusions. Astigmatism affects approximately three quarters of the Chinese population aged 65 years and older in Taiwan. With increasing age, the prevalence of astigmatism increases, and refractive and corneal astigmatism shift toward ATR. Continuous corneal changes appear to be responsible for the age trend in refractive astigmatism. The severity of lens opacity plays only a minor role in the change of internal astigmatism. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553585 Wed, 28 Dec 2011 05:00:00 +0100 5553585 http://www.medworm.com/index.php?rid=5553584&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9644%3Frss%3D1 Conclusions. Optic SAS is seen in 93% of highly myopic eyes, and the SAS appears to be dilated in highly myopic eyes. The expanded area of exposure to CSF pressure along with thinning of the posterior eye wall may influence staphyloma formation and the way in which certain diseases, such as glaucoma, are manifested. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553584 Wed, 28 Dec 2011 05:00:00 +0100 5553584 http://www.medworm.com/index.php?rid=5553583&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9636%3Frss%3D1 Conclusions. In this adult rural Central Indian population with low mean BMI, the prevalence of corneal arcus was 10.7% ± 1.0%. The only systemic parameter associated with corneal arcus was increasing age (P < 0.001). Corneal arcus was not associated with dyslipidemia, diabetes mellitus, arterial hypertension, alcohol consumption, or smoking. In this population with low BMI, corneal arcus was not a clinical biomarker for major metabolic disorders. The intereye associations between corneal arcus and low intraocular pressure, thin central cornea, and hyperopia may be of importance in the ophthalmic examination. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553583 Tue, 20 Dec 2011 05:00:00 +0100 5553583 http://www.medworm.com/index.php?rid=5553582&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9629%3Frss%3D1 Conclusions. In a non-glaucomatous population, optic nerve measurements with SD-OCT vary with disc area, age, IOP, AL, lens nuclear color, and signal strength, but systemic parameters have little influence. This information may be useful for interpretation of SD-OCT measurements. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553582 Tue, 20 Dec 2011 05:00:00 +0100 5553582 http://www.medworm.com/index.php?rid=5553581&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9624%3Frss%3D1 Conclusions. Constitutive modeling studies suggest at least two trajectory-dependent mechanisms for optic nerve rupture with paintball impact on the eye. Tangential glancing blows produce strain-rate rotational avulsion, abscising the optic nerve with minimal internal globe disruption, whereas off-center direct impact produces slower rotational-rebound evulsion, traumatizing the globe and breaching the nerve posteriorly. The latter mechanism would be expected to arise more commonly and would most likely be clinically masked by accompanying intraocular injury. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553581 Tue, 20 Dec 2011 05:00:00 +0100 5553581 http://www.medworm.com/index.php?rid=5553580&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9614%3Frss%3D1 Conclusions. AOSLO images of two patients with molecularly characterized XLRS revealed increased cone spacing and abnormal packing in the macula of each patient, but cone coverage and function were near normal outside the central foveal schisis cavities. Although cone density is reduced, the preservation of wave-guiding cones at the fovea and eccentric macular regions has prognostic and therapeutic implications for XLRS patients with foveal schisis. (Clinical Trials.gov number, NCT00254605.) (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553580 Tue, 20 Dec 2011 05:00:00 +0100 5553580 http://www.medworm.com/index.php?rid=5553579&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9612-a%3Frss%3D1 (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553579 Tue, 20 Dec 2011 05:00:00 +0100 5553579 http://www.medworm.com/index.php?rid=5553578&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9612%3Frss%3D1 (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553578 Tue, 20 Dec 2011 05:00:00 +0100 5553578 http://www.medworm.com/index.php?rid=5553577&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9610-a%3Frss%3D1 (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553577 Tue, 20 Dec 2011 05:00:00 +0100 5553577 http://www.medworm.com/index.php?rid=5553576&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9610%3Frss%3D1 (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553576 Tue, 20 Dec 2011 05:00:00 +0100 5553576 http://www.medworm.com/index.php?rid=5553575&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9598%3Frss%3D1 Conclusions. The results of this study indicate that RPE survival is possible on AMD BM and offer a method that could be developed for enhancing transplanted cell survival on AMD BM. Increased ECM deposition may account for improved cell survival after culture in BCEC-CM. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553575 Tue, 20 Dec 2011 05:00:00 +0100 5553575 http://www.medworm.com/index.php?rid=5553574&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9591%3Frss%3D1 Conclusions. Overexpression of human XIAP protects ARPE-19 cells against H2O2-induced oxidative cell death by acting downstream on the apoptotic pathway. XIAP gene therapy using AAV may provide a means of reducing the effect of oxidative stress to RPE cells in age-related macular degeneration. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553574 Tue, 20 Dec 2011 05:00:00 +0100 5553574 http://www.medworm.com/index.php?rid=5553573&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9581%3Frss%3D1 Conclusions. On fdOCT scans, patients with RP, CHM, and STGD all have a TZ between relatively healthy and severely affected retina. The patterns of changes in the receptor layers are similar within a disease category, but different across categories. The findings suggest that the pattern of progression of each disease is distinct and may offer clues for strategies in the development of future therapies. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553573 Tue, 20 Dec 2011 05:00:00 +0100 5553573 http://www.medworm.com/index.php?rid=5553572&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9573%3Frss%3D1 Conclusions. The WIT is well tolerated by the rabbit eye. Its measurements are reproducible and in close concordance with manometry. A downward IOP drift warrants further investigation. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553572 Tue, 20 Dec 2011 05:00:00 +0100 5553572 http://www.medworm.com/index.php?rid=5553571&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9567%3Frss%3D1 Conclusions. LG gene delivery by AAV vectors appears to be both safe and well tolerated. The choice of vector influences both the overall transduction activity, as well as the spread of vector to other organs. This work supports the use of AAV-mediated gene therapy for dry eye. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553571 Tue, 20 Dec 2011 05:00:00 +0100 5553571 http://www.medworm.com/index.php?rid=5553570&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9561%3Frss%3D1 Conclusions. In very young children aged 48 to 72 months, narrower retinal arteriolar and venular caliber was associated with elongated axial length. Narrower retinal venular caliber was associated with larger corneal curvature. This suggests that the major structural correlate of myopia might have an effect on retinal microvasculature from early childhood. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553570 Tue, 20 Dec 2011 05:00:00 +0100 5553570 http://www.medworm.com/index.php?rid=5553569&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9555%3Frss%3D1 Conclusions. Age is critical for evaluation of choroidal thickness. However, SFCT has no correlation with age in subjects younger than 60 years of age. In subjects older than 60 years of age, SFCT was significantly negatively correlated with age, and decreased by 5.40 μm for each year of life. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553569 Tue, 20 Dec 2011 05:00:00 +0100 5553569 http://www.medworm.com/index.php?rid=5553568&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9548%3Frss%3D1 Conclusions. Cultured OMEC have the potential to act as autografts for ocular surface reconstruction in patients with bilateral ocular surface disease and can prove to be particularly beneficial to ameliorate the mucin deficiency state in dry eye associated with OSD. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553568 Tue, 20 Dec 2011 05:00:00 +0100 5553568 http://www.medworm.com/index.php?rid=5553567&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9541%3Frss%3D1 (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553567 Fri, 16 Dec 2011 05:00:00 +0100 5553567 http://www.medworm.com/index.php?rid=5553566&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9539%3Frss%3D1 (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553566 Fri, 16 Dec 2011 05:00:00 +0100 5553566 http://www.medworm.com/index.php?rid=5553565&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9534%3Frss%3D1 Conclusions. The overall pattern of results is not consistent with the expectation of scale invariance underlying the MAR scale. Optotypes that conform to the expectations of scale invariance are needed to improve vision assessment and to provide equivalency of VA defined in terms of MAR and cpd. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553565 Fri, 16 Dec 2011 05:00:00 +0100 5553565 http://www.medworm.com/index.php?rid=5553564&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9527%3Frss%3D1 Conclusions. These studies demonstrate that β-adrenergic receptor agonists in vitro can restore the loss of insulin receptor activity noted in diabetes. By decreasing the levels of TNF-α and decreasing the phosphorylation of IRS-1Ser307 while increasing tyrosine phosphorylation of insulin receptor, these results suggest a possible mechanism by which restoration of β-adrenergic receptor signaling may protect the retina against diabetes-induced damage. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553564 Fri, 16 Dec 2011 05:00:00 +0100 5553564 http://www.medworm.com/index.php?rid=5553563&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9523%3Frss%3D1 Conclusions. Genetic factors play a significant role in determining macular thickness in the Korean population. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553563 Fri, 16 Dec 2011 05:00:00 +0100 5553563 http://www.medworm.com/index.php?rid=5553562&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9516%3Frss%3D1 Conclusions. Optical disturbances at the central optical zone of the cornea in dry eye disease may affect visual performance. Functional VA measurement may be an applicable method of evaluating visual performance in dry eyes that is as efficient as wavefront aberration measurements. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553562 Fri, 16 Dec 2011 05:00:00 +0100 5553562 http://www.medworm.com/index.php?rid=5553561&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9503%3Frss%3D1 Conclusions. MECs can be isolated from rat lacrimal glands, and they express P2X7, P2Y1, P2Y11, and P2Y13 purinergic receptors. Surprisingly, BzATP binds the P2Y1 receptor, which is primarily responsible for the BzATP-stimulated increase in [Ca2+]i. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553561 Fri, 16 Dec 2011 05:00:00 +0100 5553561 http://www.medworm.com/index.php?rid=5553560&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9497%3Frss%3D1 Conclusions. The green-light FAF images (514 nm) are superior for the accurate analysis of small, central, pathologic changes, and for the determination of the central GA lesion size. Using only blue-light FAF could lead to an overinterpretation of the size of atrophic patches and the center involvement, because it suggests the presence of atrophy in the fovea. (ClinicalTrials.gov number, NCT00494325.) (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553560 Fri, 16 Dec 2011 05:00:00 +0100 5553560 http://www.medworm.com/index.php?rid=5553559&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9489%3Frss%3D1 Conclusions. This study strongly suggests that the regulation of choroidal blood flow, which depends on the orthosympathetic and parasympathetic systems, is unaltered in men with OSA who have no comorbidities. (ClinicalTrials.gov number, NCT00874913.) (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553559 Fri, 16 Dec 2011 05:00:00 +0100 5553559 http://www.medworm.com/index.php?rid=5553558&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9488-a%3Frss%3D1 (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553558 Fri, 09 Dec 2011 05:00:00 +0100 5553558 http://www.medworm.com/index.php?rid=5553557&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9488%3Frss%3D1 (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553557 Fri, 09 Dec 2011 05:00:00 +0100 5553557 http://www.medworm.com/index.php?rid=5553556&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9478%3Frss%3D1 Conclusions. These results indicate that VEGF plays a critical role in survival and maintenance of RPE integrity. Potential undesired off-target effects should be considered with chronic use of anti-VEGF agents. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553556 Fri, 09 Dec 2011 05:00:00 +0100 5553556 http://www.medworm.com/index.php?rid=5553555&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9470%3Frss%3D1 Conclusions. A rapid, light-activated technique produces strong, immediate bonding between amnion and cornea and merits further evaluation for ocular surface surgeries. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553555 Fri, 09 Dec 2011 05:00:00 +0100 5553555 http://www.medworm.com/index.php?rid=5553554&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9457%3Frss%3D1 Conclusions. All the visual function tests had good diagnostic capacity. Combination of the 14-Hz flicker thresholds and dynamics of the PSR test provided optimal quantitative assessment of retinal function in early AMD, suggesting that this set is a potentially useful clinical tool for following progression of early AMD and assessing the efficacy of interventions. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553554 Fri, 09 Dec 2011 05:00:00 +0100 5553554 http://www.medworm.com/index.php?rid=5553553&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9452%3Frss%3D1 Conclusions. The interocular similarities may explain the better visual resolution in the half-binocular condition than in the dichoptic condition for all age groups tested. The results suggest that interocular interactions underpinning resolution acuity under these viewing conditions are developed in early childhood. The foveal crowding effect was found to be apparent at the beginning of school age, and diminished with maturation. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553553 Fri, 09 Dec 2011 05:00:00 +0100 5553553 http://www.medworm.com/index.php?rid=5553552&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9445%3Frss%3D1 Conclusions. To the knowledge of the authors, this is the first demonstration that nicotine by itself affects responses in the human retina. These data support reports of the expression of nicotinic acetylcholine receptors in rabbit and nonhuman primate retina. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553552 Fri, 09 Dec 2011 05:00:00 +0100 5553552 http://www.medworm.com/index.php?rid=5553551&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9438%3Frss%3D1 Conclusions. Endothelial NOS overexpression lowers IOP by increasing pressure-dependent drainage in the mouse eye. Data are consistent with NO's having a mechanoregulatory role in aqueous humor dynamics, with eNOS induction at elevated IOPs leading to increased pressure-dependent outflow. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553551 Fri, 09 Dec 2011 05:00:00 +0100 5553551 http://www.medworm.com/index.php?rid=5553550&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9431%3Frss%3D1 Conclusions. Surface compliance changes in the normal monkey ONH primarily reflect prelaminar and peripapillary deformation. SD-OCT compliance testing will further our understanding of the effects of IOP on the ONH and help improve and validate numerical models of ONH biomechanics. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553550 Fri, 09 Dec 2011 05:00:00 +0100 5553550 http://www.medworm.com/index.php?rid=5553549&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9425%3Frss%3D1 Conclusions. The aqueous humor dynamics of black African and white Caucasian patients with POAG or OHT have no significant differences. However, the significantly thinner corneas of the black patients may be masking potential differences in outflow facility and IOP measurements between the racial groups. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553549 Fri, 09 Dec 2011 05:00:00 +0100 5553549 http://www.medworm.com/index.php?rid=5553548&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9416%3Frss%3D1 Conclusions. The results suggest that reading comprehension is robust against changes in binocular coordination that result from moderate text degradation; nevertheless, these changes are likely to be linked to the development of fatigue and visual strain in near reading conditions. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553548 Fri, 09 Dec 2011 05:00:00 +0100 5553548 http://www.medworm.com/index.php?rid=5553547&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9411%3Frss%3D1 Conclusions. K13 has shown to be a new marker of conjunctival differentiation. The immunocytochemical search for the K13/K19 couple by corneal IC provides a simple and reliable method for diagnosing LSCD, whereas the level of K12 could provide a score of disease severity. On the other hand, the authors question the corneal specificity of K3 as conventionally established. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553547 Fri, 09 Dec 2011 05:00:00 +0100 5553547 http://www.medworm.com/index.php?rid=5553546&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9404%3Frss%3D1 Conclusions. Compared with the Caucasians, the ethnic Chinese had smaller ARA and TISA, but greater dark-to-light changes in AOD and TISA, independent of refractive status and overall ocular anterior segment dimensions. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553546 Fri, 09 Dec 2011 05:00:00 +0100 5553546 http://www.medworm.com/index.php?rid=5553545&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9403%3Frss%3D1 (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553545 Fri, 09 Dec 2011 05:00:00 +0100 5553545 http://www.medworm.com/index.php?rid=5553544&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9397%3Frss%3D1 Conclusions. Compared with the current gold standard, computerized repeating and averaging of acuity measurements improve specificity and sensitivity when identifying true changes. The 160-second increase in test time should be set against the considerable economic and clinical benefits that may result. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553544 Fri, 09 Dec 2011 05:00:00 +0100 5553544 http://www.medworm.com/index.php?rid=5553543&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9391%3Frss%3D1 Conclusions. HDP-cyclic CDV, under simulated physiologic conditions, slowly converts to HDP-CDV, another potent anti-CMV prodrug that may be taken up by retinal cells and metabolized further to the active antiviral metabolite, cidofovir diphosphate. Taken together, these observations help to explain the ability of a single intravitreal dose of HDP-cyclic-CDV to prevent viral retinitis for up to 68 days in a rabbit model. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553543 Fri, 09 Dec 2011 05:00:00 +0100 5553543 http://www.medworm.com/index.php?rid=5553542&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9379%3Frss%3D1 Conclusions. Quantitative AF imaging appears feasible. It may enhance understanding of retinal degeneration, serve as a diagnostic aid and as a sensitive marker of disease progression, and provide a tool to monitor the effects of therapeutic interventions. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553542 Fri, 09 Dec 2011 05:00:00 +0100 5553542 http://www.medworm.com/index.php?rid=5553541&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9373%3Frss%3D1 Conclusions. Tear menisci volumes estimated by OCT may have great potential in the diagnosis and monitoring of SSDE. They can also reflect ocular surface damage and tear film stability. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553541 Fri, 09 Dec 2011 05:00:00 +0100 5553541 http://www.medworm.com/index.php?rid=5553540&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9368%3Frss%3D1 Conclusions. This report describes CEACAM1 expression in uveal melanoma. Correlation with poor prognostic factors such as epithelioid cell type and networks of extracellular matrix pattern was found, but definitive prognostic conclusions still cannot be deduced. Additional validation studies on the use of CEACAM1 expression as a prognostic marker are warranted. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553540 Fri, 09 Dec 2011 05:00:00 +0100 5553540 http://www.medworm.com/index.php?rid=5553539&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9362%3Frss%3D1 Conclusions. The 12-month data support the hypothesis that reducing peripheral hyperopia can alter central refractive development and reduce the rate of progress of myopia. (chictr.org number, chiCTR-TRC-00000029 or chiCTR-TRC-00000032.) (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553539 Fri, 09 Dec 2011 05:00:00 +0100 5553539 http://www.medworm.com/index.php?rid=5553538&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9353%3Frss%3D1 Conclusions. Reliable activation of RGCs by electrical stimulation in vitro using an MPDA demonstrates the feasibility of developing solar cell–based subretinal prostheses that potentially could be developed into a power-free device able to restore vision. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553538 Fri, 09 Dec 2011 05:00:00 +0100 5553538 http://www.medworm.com/index.php?rid=5553537&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9345%3Frss%3D1 Conclusions. The vulnerability of retinal capillaries to hypoxia is boosted by a mechanism involving the polyamine/KATP channel/Ca2+ influx/CICR pathway. Discovery of this pathway should provide new targets for pharmacological interventions to minimize hypoxia-induced damage in retinal capillaries. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553537 Fri, 09 Dec 2011 05:00:00 +0100 5553537 http://www.medworm.com/index.php?rid=5553536&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9339%3Frss%3D1 Conclusions. In eyes with CMV retinitis, both the i2k Retina and AutoMontage software packages appear to create higher quality mosaics than does IMAGEnet. Automated retinal mosaic imaging may be valuable in diagnosing CMV retinitis and observing disease progression. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553536 Fri, 09 Dec 2011 05:00:00 +0100 5553536 http://www.medworm.com/index.php?rid=5553535&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9333%3Frss%3D1 Conclusions. The adjunctive use of UV-A and B2 therapy did not demonstrate antitrophozoite activity; in vivo UV-A and B2 did not demonstrate efficacy in this model. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553535 Fri, 09 Dec 2011 05:00:00 +0100 5553535 http://www.medworm.com/index.php?rid=5553534&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9327%3Frss%3D1 Conclusions. This technique facilitates the separation of Descemet's membrane from the stroma without affecting endothelial cell viability. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553534 Fri, 09 Dec 2011 05:00:00 +0100 5553534 http://www.medworm.com/index.php?rid=5553533&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9316%3Frss%3D1 Conclusions. These findings suggest that early changes in astrocytes are coincident with inner retinal hypoxia and ganglion cell functional deficits, whereas Müller cell gliosis and more extensive decreases in neuronal function occur later. Astrocytes may play an early and key role in changes in retinal vasculature and inner retinal dysfunction in diabetes. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553533 Fri, 02 Dec 2011 05:00:00 +0100 5553533 http://www.medworm.com/index.php?rid=5553532&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9310%3Frss%3D1 Conclusions. OPN is upregulated in laser-irradiated choroidal tissue. Endogenous OPN is required for macrophage inflammation and VEGF expression in choroidal tissue and for CNV development after retinal photocoagulation in mice. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553532 Fri, 02 Dec 2011 05:00:00 +0100 5553532 http://www.medworm.com/index.php?rid=5553531&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9304%3Frss%3D1 Conclusions. This is the first report of marked intrafamilial variability associated with mutations in the PRPF8 gene, including incomplete penetrance. PRPF8 mutations should be suspected in patients with adRP and variable expressivity. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553531 Fri, 02 Dec 2011 05:00:00 +0100 5553531 http://www.medworm.com/index.php?rid=5553530&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9298%3Frss%3D1 Conclusions. Substratum compliance profoundly influenced HTM cell behaviors and modulated the response of HTM cells to Lat-B. The inclusion of substratum compliance that reflects healthy or glaucomatous HTM results in cell behaviors and responses to therapeutic agents in vitro that may more accurately reflect in vivo conditions. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553530 Fri, 02 Dec 2011 05:00:00 +0100 5553530 http://www.medworm.com/index.php?rid=5553529&cid=s_32299_30_f&fid=32299&url=http%3A%2F%2Fwww.iovs.org%2Fcgi%2Fcontent%2Ffull%2F52%2F13%2F9291%3Frss%3D1 Conclusions. FECD CECs are more susceptible to oxidative DNA damage and oxidative-stress–induced apoptosis than normal. Increased activation of p53 in FECD suggests that it mediates cell death in susceptible CECs. The authors conclude that p53 plays a critical role in complex mechanisms regulating oxidative-stress–induced apoptosis in FECD. (Source: Investigative Ophthalmology) Investigative Ophthalmology journals http://www.medworm.com/rss/comments.php?id=5553529 Fri, 02 Dec 2011 05:00:00 +0100 5553529