MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Italian Journal of Pediatrics' source. Thu, 09 Feb 2012 01:09:30 +0100 http://www.medworm.com/index.php?rid=5651316&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F38%2F1%2F7 Conclusion: Mandibular Distraction Osteogenesis is a good solution in solving respiratory distress when other procedures are failed in paediatric patients with severe micrognatia. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=5651316 Thu, 02 Feb 2012 05:00:00 +0100 5651316 http://www.medworm.com/index.php?rid=5651318&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F38%2F1%2F5 Conclusions: The activity volumes would seem to support the setting up of a Freestanding Regional Center of Pediatric Day Surgery. This Center represents the healthcare facility that is most likely to allow a de-hospitalization process. Subsequent studies will be required to confirm the validity of this pilot study. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=5651318 Wed, 01 Feb 2012 05:00:00 +0100 5651318 http://www.medworm.com/index.php?rid=5651317&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F38%2F1%2F6 Conclusion: The hour-specific TSB nomogram is able to predict all neonates without risk of non physiologic hyperbilirubinemia only after 48 to 72 hours of life. The combination of TSB determination and risk factors for hyperbilirubinemia could facilitate a safe discharge from the hospital and a targeted intervention and follow-up. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=5651317 Wed, 01 Feb 2012 05:00:00 +0100 5651317 http://www.medworm.com/index.php?rid=5651319&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F38%2F1%2F4 Acute lymphoblastic leukemia is the most common malignancy in childhood. Continuous progress in risk-adapted treatment for childhood acute lymphoblastic leukemia has secured 5-year event-free survival rates of approximately 80% and 8-year survival rates approaching 90%. Almost 75% of survivors, however, have a chronic health condition negatively impacting on cardiovascular morbidity and mortality. Obesity can be considered one of the most important health chronic conditions in the general population, with an increasing incidence in patients treated for childhood cancers and especially in acute lymphoblastic leukemia survivors who are, at the same time, more at risk of experiencing precocious cardiovascular and metabolic co-morbidities. The hypothalamic-pituitary axis damage secondary to ca... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=5651319 Fri, 27 Jan 2012 05:00:00 +0100 5651319 http://www.medworm.com/index.php?rid=5651320&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F38%2F1%2F3 Conclusions: Our data show that there are significant correlations between different neuropsychological and behavioural measures. It is therefore possible to rationalize diagnostic protocols without a significant information reduction. A deeper analysis will require a preliminary definition of the psychometric properties of used tools. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=5651320 Thu, 26 Jan 2012 05:00:00 +0100 5651320 http://www.medworm.com/index.php?rid=5585920&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F38%2F1%2F1 Conclusions: Sardinian BP tables emphasizes the need to integrate the previous standards with more up-to-date and representative reports on Italian children, as periodically performed in the USA, in order to increase the number of subjects to be checked, and to obtain a national coverage better and more completely representative of every geographic area of our country. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=5585920 Tue, 10 Jan 2012 05:00:00 +0100 5585920 http://www.medworm.com/index.php?rid=5585919&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F38%2F1%2F2 Background: Cystic fibrosis is a multisystem disease where the main problems are existing in the respiratory system. Aerobic exercise programs are effective in increasing physical fitness and muscle endurance in addition to chest physiotherapy.ObjectiveThe aim of this study was to evaluate the effects of chest physiotherapy and aerobic exercise training on physical fitness in young children with cystic fibrosis. Methods: Sixteen patients with cystic fibrosis, between the ages 5-13 years, were included in this study. All children were assessed at the beginning and at the end of 6 week of the training. Modified Bruce protocol was used for assessing the cardiovascular endurance. The sit-up test was used to evaluate the dynamic endurance of abdominal muscles, standing long jump was used to tes... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=5585919 Tue, 10 Jan 2012 05:00:00 +0100 5585919 http://www.medworm.com/index.php?rid=5553928&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F60 Conclusions: Children with attention deficit hyperactivity disorder had lower levels of zinc, ferritin and magnesium than healthy children but had normal copper levels. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=5553928 Thu, 29 Dec 2011 05:00:00 +0100 5553928 http://www.medworm.com/index.php?rid=5527761&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F59 Conclusions: A strong association between severe AD and poor QoL, both in children and mothers, was found in the Italian sample, in line with the international literature. Family's QoL scores were sensitively related to AD severity, more than the child's QoL, emphasising that the disease has a deep impact on the family. A significant association between age and QoL was only partially found and needs further investigation. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=5527761 Thu, 22 Dec 2011 05:00:00 +0100 5527761 http://www.medworm.com/index.php?rid=5516739&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F58 The genetic causes underlying epilepsy remain largely unknown, and the impact of available genetic data on the nosology of epilepsy is still limited. Thus, at present, classification of epileptic disorders should be mainly based on electroclinical features. Electro-clinical syndrome is a term used to identify a group of clinical entities showing a cluster of electro-clinical characteristics, with signs and symptoms that together define a distinctive, recognizable, clinical disorder. These often become the focus of treatment trials as well as of genetic, neuropsychological, and neuroimaging investigations. They are distinctive disorders identifiable on the basis of a typical age onset, specific EEG characteristics, seizure types, and often other features which, when taken together, permit a... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=5516739 Mon, 19 Dec 2011 05:00:00 +0100 5516739 http://www.medworm.com/index.php?rid=5460530&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F57 Studies undertaken in recent years have improved our understanding regarding the consequences and management of febrile urinary tract infections (UTIs), which are amongst the most common serious bacterial infections in childhood, with renal scarring a frequent outcome.In the past pyelonephritic scarring of the kidney, often associated with vesico-ureteral reflux (reflux nephropathy) was considered a frequent cause of chronic renal insufficiency in children. Increasing recognition as a consequence of improved antenatal ultrasound, that the majority of these children had congenital renal hypo-dysplasia, has resulted in a number of studies examining treatment strategies and outcomes following UTI.In recent years there is a developing consensus regarding the need for a less aggressive therapeu... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=5460530 Wed, 30 Nov 2011 05:00:00 +0100 5460530 http://www.medworm.com/index.php?rid=5433569&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F56 Conclusion: Surgery was the only risk factor significantly associated with symptomatic candidiasis and non-albicans Candida species were more common among the patients with symptomatic candidiasis.While treating symptomatic candidiasis in any PICU an increase in the incidence of non-albicans candidiasis should be considered. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=5433569 Mon, 21 Nov 2011 05:00:00 +0100 5433569 http://www.medworm.com/index.php?rid=5411721&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F55 Conclusions Meconium Related Ileus without Cystic Fibrosis responds to conservative management and softening enema in most of mature infants. In LBW clinical course is initially benign but as any long standing bowel obstruction management may present particular challenges. Clinical and plain radiographic criteria are reliable for making diagnosis and testing for Cystic Fibrosis may not be indicated. Enema may be resolutive when performed in a proper environment. . Perforated cases may be confused with NEC which is excluded by clinical history, no signs of sepsis, lab signs missing, abdominal signs missing, typical radiological signs missing. The higher complication rate is recorded among cases delivered and initially managed in Neonatal Units without co-located Surgical Facilities. Early d... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=5411721 Mon, 14 Nov 2011 05:00:00 +0100 5411721 http://www.medworm.com/index.php?rid=5402129&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F54 DiscussionA 100% increase of the number of P.E.R. visits, particularly for influenza-like illness, was recorded during weeks 42-46 of 2009 (October, 17 to November, 2); the low rate of hospitalization and the mild presentation of the infection gave rise to the conclusion that the pandemic risk was overrated. Mass media communications concerning the new virus created a disproportionate fear in the population that significantly enhanced the burden of cares at the hospital. In the absence of generally implemented measures for etiological diagnosis, the actual incidence of the H1N1 infection could not be estimated. Virus identification, in fact, was limited to children showing severe symptoms after consultancy with an infectious disease specialist. The alarming nature of the communication camp... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=5402129 Thu, 10 Nov 2011 05:00:00 +0100 5402129 http://www.medworm.com/index.php?rid=5391187&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F52 Conclusions: EPT is a safe and cheap test, easy to be executed and that could provide good prediction of the outcome of OFC; so it might be used to avoid OFC-induced anaphylaxis in children affected by CMA. It can also help avoiding dietetic restrictions in tolerant children who show sensitization towards cow's milk proteins. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=5391187 Fri, 04 Nov 2011 04:00:00 +0100 5391187 http://www.medworm.com/index.php?rid=5350474&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F51 Conclusions: The treatment of paediatric airway anomalies requires a dedicated multidisciplinary approach and a single tertiary care Centre providing rapid access to endoscopic and surgical manoeuvres on upper and lower airways and the possibility to start immediately cardiopulmonary bypass or ECMO.The preliminary experience of the Tracheal Team shows that good results can be obtained with this multidisciplinary approach in the treatment of complicated cases. The centralization of all the cases in one or few national Centres should be considered. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=5350474 Wed, 26 Oct 2011 04:00:00 +0100 5350474 http://www.medworm.com/index.php?rid=5338912&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F50 We report 3 cases of localized Castleman's disease, investigated in our Department in a 3 years period and reviewed the literature. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=5338912 Thu, 20 Oct 2011 04:00:00 +0100 5338912 http://www.medworm.com/index.php?rid=5288217&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F49 Background: Immune-related disorders may group together. The aim of this paper was to examine the prevalence of immune-based diseases in pediatric patients with inflammatory bowel disease (IBD) compared to those without IBD. Methods: Children (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=5288217 Tue, 04 Oct 2011 04:00:00 +0100 5288217 http://www.medworm.com/index.php?rid=5263550&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F48 Background: To evaluate the analgesic effect and tolerability of paracetamol syrup compared to placebo and ketoprofen lysine salt in children with pharyngotonsillitis cared by family pediatricians. Methods: A double-blind, randomized, placebo-controlled trial of a 12 mg/kg single dose of paracetamol paralleled by open-label ketoprofren lysine salt sachet 40 mg. Six to 12 years old children with diagnosis of pharyngo-tonsillitis and a Children's Sore Throat Pain (CSTP) Thermometer score > 120 mm were enrolled. Primary endpoint was the Sum of Pain Intensity Differences (SPID) of the CSTP Intensity scale by the child. Results: 97 children were equally randomized to paracetamol, placebo or ketoprofen. Paracetamol was significantly more effective than placebo in the SPID of children and parents... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=5263550 Thu, 29 Sep 2011 04:00:00 +0100 5263550 http://www.medworm.com/index.php?rid=5263551&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F47 We report on a patient in which accidental inhalation of baby powder induced severe respiratory difficulties. We also point out the benefits of surfactant administration. Surfactant contributed to the rapid improvement of the medical and radiological condition, preventing severe early and late complications and avoiding invasive approaches. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=5263551 Tue, 27 Sep 2011 04:00:00 +0100 5263551 http://www.medworm.com/index.php?rid=5252716&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F46 Leukaemia immunotherapy represents a fascinating and promising field of translational research, particularly as an integrative approach of bone marrow transplantation. Adoptive immunotherapy by the use of donor-derived expanded leukaemia-specific T cells has showed some kind of clinical response, but the major advance is nowadays represented by gene manipulation of donor immune cells, so that they acquire strict specificity towards the tumour target and potent lytic activity, followed by significant proliferation, increased survival and possibly anti-tumour memory state. This is achieved by gene insertion of Chimeric T-cell Antigen Receptors (CARs), which are artificial molecules containing antibody-derived fragments (to bind the specific target), joined with potent signalling T-Cell Recep... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=5252716 Thu, 22 Sep 2011 04:00:00 +0100 5252716 http://www.medworm.com/index.php?rid=5241085&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F45 Conclusion: The risk of asymptomatic bacteriuria is three times more common in children with sickle cell anemia than in children with normal haemoglobin. It is therefore important to screen SCA patients, especially the females for UTI and when positive, they should be treated according to the sensitivity result of the cultured organisms. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=5241085 Mon, 19 Sep 2011 04:00:00 +0100 5241085 http://www.medworm.com/index.php?rid=5241086&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F44 Background: There has been a noticeable annual increase in the number of children coming to Italy for medical treatment, just like it has happened in the rest of the European Union. In Italy, the assistance to children suffering from cancer is assured by the current network of 54 centres members of the Italian Association of Paediatric Haematology and Oncology (AIEOP), which has kept records of all demographic and clinical data in the database of Mod.1.01 Registry since 1989. Methods: We used the information stored in the already mentioned database to assess the impact of immigration of foreign children with cancer on centres' activity, with the scope of drawing a map of the assistance to these cases. Results: Out of 14,738 cases recorded by all centres in the period from 1999 to 2008, 92.... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=5241086 Sun, 18 Sep 2011 04:00:00 +0100 5241086 http://www.medworm.com/index.php?rid=5241087&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F43 Conclusions: The amount of information relevant to child health care is rapidly expanding. The ten most common diseases of the present analysis may serve as baseline data for future evaluations of the changes of type of diseases among children. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=5241087 Thu, 15 Sep 2011 04:00:00 +0100 5241087 http://www.medworm.com/index.php?rid=5241088&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F42 We present the case of a 24-year-old male who was diagnosed at the age of seven with Wiskott-Aldrich syndrome. He did not respond to intravenous gammaglobulin and he experienced recurrent pulmonary infections despite prophylactic antibiotics. The patient had no matched donor. At the age of nine, he was submitted to splenectomy and his platelet count was normalized. Fifteen years later, the patient remains asymptomatic with a normal platelet count. He is still receiving prophylactic antibiotics and no bleeding episodes or septic complications have been reported. This case demonstrates that splenectomy can represent a safe therapeutic option in selected WAS patients, provided that there is a tight follow-up program, patient education and adherence to guidelines regarding post-splenectomy pro... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=5241088 Sat, 10 Sep 2011 04:00:00 +0100 5241088 http://www.medworm.com/index.php?rid=5198546&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F41 Intrauterine growth retardation refers to a rate of growth of a fetus that is less than normal for the growth potential of a fetus (for that particular gestational age). As one of the leading causes of perinatal mortality and morbidity, intrauterine growth retardation has immense implications for the short term and long term growth of children. It is an important public health concern in the developing countries. Health statistics encompassing parameters for maternal and child health in the Indian subcontinent have shown improvement in the past few years but they are still far from perfect. Maternal health, education and empowerment bears a strong influence on perinatal outcomes including intrauterine growth retardation and should be the primary focus of any stratagem targeted at reducing ... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=5198546 Tue, 06 Sep 2011 23:00:00 +0100 5198546 http://www.medworm.com/index.php?rid=5198547&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F40 Conclusion: Antibiotic usage in first time wheezers is still quite prevalent. Presence of crackles and radiological abnormalities often prompt the usage of antibiotics in such cases. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=5198547 Sun, 04 Sep 2011 23:00:00 +0100 5198547 http://www.medworm.com/index.php?rid=5149220&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F39 Conclusions: A 1-week treatment with nebulized BDP and prn salbutamol is effective in increasing SFDs and improving cough in children with wheezing, providing a clinical rationale for the short term use of ICS in episodic wheeze exacerbations in pre-school children.Trial Registration. ClinicalTrials.gov (NCT00497523) (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=5149220 Sun, 21 Aug 2011 23:00:00 +0100 5149220 http://www.medworm.com/index.php?rid=5134311&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F38 ${item.shortDescription} (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=5134311 Mon, 15 Aug 2011 23:00:00 +0100 5134311 http://www.medworm.com/index.php?rid=5121592&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F37 ${item.shortDescription} (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=5121592 Wed, 10 Aug 2011 23:00:00 +0100 5121592 http://www.medworm.com/index.php?rid=5090277&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F36 ${item.shortDescription} (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=5090277 Mon, 01 Aug 2011 23:00:00 +0100 5090277 http://www.medworm.com/index.php?rid=5065466&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F35 ${item.shortDescription} (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=5065466 Sun, 24 Jul 2011 23:00:00 +0100 5065466 http://www.medworm.com/index.php?rid=5043211&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F34 ${item.shortDescription} (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=5043211 Mon, 18 Jul 2011 23:00:00 +0100 5043211 http://www.medworm.com/index.php?rid=5032325&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F33 Childhood hearing impairment is a common chronic condition that may have a major impact on acquisition of speech, social and physical development. Numerous literature states that injury to the vestibular organs may result in accompanying balance and motor development disorders. But still postural control and motor assessments are not a routine procedure in hearing impaired children. Hence, we aim to provide an overview on motor skill performance and balance in hearing impaired children. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=5032325 Wed, 13 Jul 2011 23:00:00 +0100 5032325 http://www.medworm.com/index.php?rid=5012806&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F32 Conclusion: Gram-negative species especially Pseudomonas and Klebsiella were the predominant causative organisms. Initial empirical choice of cefotaxime in combination with amikacin appeared to be rational choice for a given cohort. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=5012806 Sun, 10 Jul 2011 23:00:00 +0100 5012806 http://www.medworm.com/index.php?rid=5001954&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F31 Conclusion: Surveys on parental satisfaction are essential for the success of a pediatric day center. Apart from the doctors abilities to interact the parents, other factors, such as a short waiting period, a friendly and helpful staff, as well as appealing premises are essential for a high overall satisfaction. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=5001954 Mon, 04 Jul 2011 23:00:00 +0100 5001954 http://www.medworm.com/index.php?rid=4963555&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F30 Conclusions: The use of BPHR is valid, simple and accurate in this population. Race-specific thresholds are however needed. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4963555 Thu, 23 Jun 2011 23:00:00 +0100 4963555 http://www.medworm.com/index.php?rid=4940588&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F29 This study was aimed at determining the prevalence, clinical pattern of HIV infection and outcome among new patients aged (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4940588 Wed, 15 Jun 2011 23:00:00 +0100 4940588 http://www.medworm.com/index.php?rid=4925689&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F28 We present a practical guide to the management of paediatric constipation and evaluate the current evidence for treatment regimens, to help the clinician in treating a condition that can be distressing and has a significant impact on affected families. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4925689 Sun, 12 Jun 2011 23:00:00 +0100 4925689 http://www.medworm.com/index.php?rid=4916185&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F27 Conclusions: Invasive diagnostic-therapeutic procedures performed in Italian Pediatric Hemato-Oncology Units are considered painful by all the caregivers involved. Pain management is generally considered good. Aprioristically opinions about pain depend on invasiveness of the procedure and on the professional role. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4916185 Thu, 09 Jun 2011 23:00:00 +0100 4916185 http://www.medworm.com/index.php?rid=4849296&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F25 A Working Group of the Joint Commission "Italian National Committee of Bioethics" and "Italian National Committee for Biosafety Biotechnologies and Life Sciences" has recommended a National Network of Regional Newborn Screening Repositories the for collection of residual dried blood samples, coordinated by the Italian National Institute of Health. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4849296 Fri, 20 May 2011 23:00:00 +0100 4849296 http://www.medworm.com/index.php?rid=4849295&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F26 Conclusions: SBP is a rather common complication in children with CLD. Culture of the ascitic fluid is not always diagnostic of infection. Biochemical parameters of the ascitic fluid definitely add to the diagnostic accuracy. LDH ascitic/serum ratio 0.5, an arterial-ascitic pH gradient 0.1 and total ascitic fluid protein 1 gm/dl are the most significant parameters suggesting infection. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4849295 Fri, 20 May 2011 23:00:00 +0100 4849295 http://www.medworm.com/index.php?rid=4834947&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F24 Conclusions: This observational study in a given area of North-East Italy confirms the rather favourable prognosis of children with influenza A H1N1 (2009). Pre-existing conditions, and which is new, significant anemia, are risk factors for a complicated course. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4834947 Wed, 18 May 2011 23:00:00 +0100 4834947 http://www.medworm.com/index.php?rid=4834949&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F22 Cystic Fibrosis (CF) is the most frequent recessive disease of Caucasian patients. Association with other diseases or syndromes has previously been reported. Co-morbidity may be a challenge for clinicians, who have to face more severe problems.We have described a CF infant, F508del homozygote, diagnosed by neonatal screening, who also had a chromosome 18q terminal deletion [del (18)(q22-qter)]. Some clinical features of the 18q deletion: e.g., cardiopathy, gastro-oesophageal reflux and severe muscular hypotonia, worsened the CF clinical picture and his quality of life, with repeated pulmonary exacerbations and failure to thrive in the first six months of life. The treatment strategy was chosen following an accurate multi-disciplinary team study of overlapping chromosome syndrome and CF sym... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4834949 Mon, 16 May 2011 23:00:00 +0100 4834949 http://www.medworm.com/index.php?rid=4834948&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F23 This study assesses the parents' Willingness To Pay (WTP) for One Stop Anesthesia (OSA). OSA is part of a free screening procedure that determines the timing of the anesthesiological assessment. In OSA-positive patients, the preoperative assessment is carried out on the same day as the surgery. The OSA allows patients who have to undergo surgery in a pediatric day surgery to avoid accessing the pre-admission clinic.MethodThis is a descriptive cohort study. A sample of 106 parents were interviewed directly by means of a questionnaire. The questionnaire builds a hypothetical scenario where the interviewee has a chance to buy the OSA health service with the WTP. The WTP values are distributed in classes and are contingent to the market built in the questionnaire. The Chi Square and Cramer's V... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4834948 Mon, 16 May 2011 23:00:00 +0100 4834948 http://www.medworm.com/index.php?rid=4823813&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F21 Conclusion: Children on anti-epileptic treatment with VPA or CBZ might demonstrate major signs of renal tubular dysfunction, reflected by NAG/Cr activity index. This side effect can be potentially more occurred following VPA administration. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4823813 Fri, 13 May 2011 23:00:00 +0100 4823813 http://www.medworm.com/index.php?rid=4816154&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F20 We describe here a case of HHCS that offers some interesting clues for the daily practice. Our patient is a 6 year old Italian boy who came to our attention after some time of diagnostic uncertainties because of persistently high levels of ferritin with no apparent cause. We were guided to the suspect of this syndrome by the family history (5 members with various degrees of cataract developed in first infancy). High levels of serum ferritin and specific genetic testing (mutation A37C) confirmed the diagnosis. This case underlines the need of considering rare genetic syndromes, including hereditary hyperferritinemia cataract syndrome, in the differential diagnosis of raised serum ferritin in children and the importance of paying attention to family history in considering a patient with isol... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4816154 Wed, 11 May 2011 23:00:00 +0100 4816154 http://www.medworm.com/index.php?rid=4728129&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F19 We report the case of a 2 months old male infant with persistent febrile episode, transferred to us from another institution, who presented on echocardiography giant aneurysms on both coronary arteries. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4728129 Sat, 16 Apr 2011 23:00:00 +0100 4728129 http://www.medworm.com/index.php?rid=4720876&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F18 Eosinophilic digestive disease (EDD) includes a broad spectrum of clinical presentations due to eosinophilic inflammation involving anywhere from the esophagus to the rectum.The heterogeneity in the clinical presentations of EDD is determined by the site and depth of eosinophilic infiltration. The sites of inflammation determine the nomenclature for EDD. The most well characterized of these, eosinophilic esophagitis (EE), eosinophilic gastroenteritis (EG), and eosinophilic colitis or enterocolitis. While the depth of esosinophilic infiltration through the three main layers (mucosa, musculosa and serosa) determines the prominent clinical manifestation. The recent advances in gastrointestinal endoscopy and the increasing awareness and diagnosis of EDD, in my viewpoint, can be of help to add ... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4720876 Fri, 15 Apr 2011 23:00:00 +0100 4720876 http://www.medworm.com/index.php?rid=4716656&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F17 We report our experience in managing a 17-year-old female with AIN and subsequent renal injury following an acetaminophen overdose in conjunction with acute alcohol intoxication. It is well established that acetaminophen metabolism, particularly at high doses, produces reactive metabolites that may induce renal and hepatic toxicity. It is also plausible however, that such reactive species could instead alter renal peptide immunogenicity, thereby inducing AIN. In the following report, we review a possible mechanism for the acetaminophen-induced AIN observed in our patient and also discuss the potential involvement of acute alcohol ingestion in disease onset. The objective of our report is to increase awareness of healthcare professionals to the potential involvement of these commonly used a... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4716656 Thu, 14 Apr 2011 23:00:00 +0100 4716656 http://www.medworm.com/index.php?rid=4700195&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F16 The early identification of pre-lingual deafness is necessary to minimize the consequences of hearing impairment on the future communication skills of a baby.According to the most recent international guidelines the deafness diagnosis must occur before the age of three months and the prosthetic-rehabilitative treatment with atraditional hearing aid should start within the first six months. When a Cochlear implant becomes necessary, the treatment should start between the age of 12 months and 18 months. The only way to diagnose the problem early is the implementation ofuniversal neonatal audiological screening programs. Transient evoked otoacoustic emissions (TEOAE) is the most adequate test because it's accurate, economic and of simple execution. Automatic auditory brainstem response (AABR)... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4700195 Sun, 10 Apr 2011 23:00:00 +0100 4700195 http://www.medworm.com/index.php?rid=4688847&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F15 Conclusion: primary hypothyroidism should be considered in the differential diagnosis of solid mass lesions of the pituitary gland. Examination of thyroid function in patients with sellar and suprasellar masses revealed by MRI may avoid unnecessary operations which can cause irreversible complications. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4688847 Wed, 06 Apr 2011 23:00:00 +0100 4688847 http://www.medworm.com/index.php?rid=4688848&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F14 This study was conducted to describe the epidemiology of ALRTI associated with RSV among children [less than or equal to] 5 years old in Egypt.Patients and Methods: We enrolled 427 children [less than or equal to] 5 years old diagnosed with ALRTI attending the outpatient clinic or Emergency Department (ED) of Children Hospital, Cairo University during a one- year period. Nasopharyngeal aspirates were obtained from the patients, kept on ice and processed within 2 hours of collection. Immunoflourescent assay (IFA) for RSV was performed. Results: 91 cases (21.3%) had viral etiology with RSV antigens detected in 70 cases (16.4%). The RSV positive cases were significantly younger than other non-RSV cases (mean age 8.2 months versus 14.2 months, p (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4688848 Tue, 05 Apr 2011 23:00:00 +0100 4688848 http://www.medworm.com/index.php?rid=4509157&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F12 This article addresses ethical and legal issues arising from the regulation and makes recommendations for the framework conditions facilitating the development of clinical research with children. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4509157 Wed, 23 Feb 2011 00:00:00 +0100 4509157 http://www.medworm.com/index.php?rid=4365684&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F5 We report satisfactory results within the context of a directed weaning protocol. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4365684 Wed, 19 Jan 2011 00:00:00 +0100 4365684 http://www.medworm.com/index.php?rid=4365683&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F6 Conclusion: Freezing breast milk at -20degreesC and pasteurization may respectively reduce or eliminate the viral load. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4365683 Wed, 19 Jan 2011 00:00:00 +0100 4365683 http://www.medworm.com/index.php?rid=4365682&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F7 One of the objectives of the Paediatric Regulation (EC) No 1901/2006, is to foster high quality ethical research on medicinal products to be used in children. To achieve this objective, the EMA is responsible for developing a European paediatric network of existing national and European networks and centres with specific expertise in research and clinical trials relating to paediatric medicines.Following the publication of research quality requirements, a set of recognition criteria, which have to be fulfilled to become a member of ENPR-EMA were agreed . So far, 32 networks and centres (of 62 identified networks ) submitted self-assessment reports indicating whether or not they fulfill the agreed minimum criteria. Sixteen networks ( 26% of 62 identified networks) fulfilled all minimum crit... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4365682 Wed, 19 Jan 2011 00:00:00 +0100 4365682 http://www.medworm.com/index.php?rid=4328191&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F4 Conclusions: The data suggest specific interventions for preterm infant development and their reference systems and, at the same time, can guide paediatrician and neonatologist dealing with preterm infants, in focalizing and monitoring, even since health status assessments, specific areas of development that, since preschool age, can highlight the presence of real forerunners of maladjustments and likely configurations of cognitive, emotional or behaviour disadaptive functioning. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4328191 Mon, 10 Jan 2011 00:00:00 +0100 4328191 http://www.medworm.com/index.php?rid=4315479&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F1 The objective of this study was to evaluate the relationship between the prevalence of asthma symptoms and obesity among school-age children in the city of Ahvaz, Iran. Methods: A total of 903 children, 7 to 11 years of age, were enrolled in this study through cluster sampling. The International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was used to identify the children who were currently suffering from asthma. Height and weight were measured and body mass index (BMI) was calculated in kg/m2. Overweight was defined as BMI greater than the age- and sex-specific 85th percentile, and obesity as BMI greater than the 95th percentile. We determined the relationship between obesity and asthma symptoms by chi-square tests. Results: The prevalence of wheeze ever, current whee... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4315479 Thu, 06 Jan 2011 00:00:00 +0100 4315479 http://www.medworm.com/index.php?rid=4315478&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F2 Ischemia of the basal ganglia as an immediate consequence of minor head injury in children is rare ( (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4315478 Thu, 06 Jan 2011 00:00:00 +0100 4315478 http://www.medworm.com/index.php?rid=4315477&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F37%2F1%2F3 Conclusions: Italian children affected with a community acquired urinary tract infection are initially managed orally with coamoxyclav or parenterally with ceftriaxone. The results of the present retrospective analysis support this attitude. Parenteral ceftriaxone or an aminoglycoside should be considered for patients on antimicrobial prophylaxis or recently prescribed antimicrobials. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4315477 Thu, 06 Jan 2011 00:00:00 +0100 4315477 http://www.medworm.com/index.php?rid=4279272&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F79 Attention-Deficit/Hyperactivity Disorder is not a single pathophysiological entity and appears to have a complex etiology. There are multiple genetic and environmental risk factors with small individual effect that act in concert to create a spectrum of neurobiological liability. Structural imaging studies show that brains of children with Attention-Deficit/Hyperactivity Disorder are significantly smaller than unaffected controls. The prefrontal cortex, basal ganglia and cerebellum are differentially affected and evidence indicating reduced connectivity in white matter tracts in key brain areas is emerging. Genetic, pharmacological, imaging, and animal models highlight the important role of dopamine dysregulation in the neurobiology of Attention-Deficit/Hyperactivity Disorder. To date, sti... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4279272 Wed, 22 Dec 2010 00:00:00 +0100 4279272 http://www.medworm.com/index.php?rid=4255618&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F78 There is a high frequency of diarrhea and vomiting in childhood. As a consequence the focus of the present review is to recognize the different body fluid compartments, to clinically assess the degree of dehydration, to know how the equilibrium between extracellular fluid and intracellular fluid is maintained, to calculate the effective blood osmolality and discuss both parenteral fluid maintenance and replacement. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4255618 Mon, 13 Dec 2010 00:00:00 +0100 4255618 http://www.medworm.com/index.php?rid=4165634&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F76 Human SCID (Severe Combined Immunodeficiency) is a prenatal disorder of T lymphocyte development, that depends on the expression of numerous genes. The knowledge of the genetic basis of SCID is essential for diagnosis (e.g., clinical phenotype, lymphocyte profile) and treatment (e.g., use and type of pre-hematopoietic stem cell transplant conditioning).Over the last years novel genetic defects causing SCID have been discovered, and the molecular and immunological mechanisms of SCID have been better characterized. Distinct forms of SCID show both common and peculiar (e.g., absence or presence of nonimmunological features) aspects, and they are currently classified into six groups according to prevalent pathophysiological mechanisms: impaired cytokine-mediated signaling; pre-T cell receptor ... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4165634 Mon, 15 Nov 2010 00:00:00 +0100 4165634 http://www.medworm.com/index.php?rid=4156913&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F75 Conclusion: These findings indicate that children with hearing impairment, both with and without motor impairment, have a diminished health-related quality of life. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4156913 Fri, 12 Nov 2010 00:00:00 +0100 4156913 http://www.medworm.com/index.php?rid=4156914&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F74 Assisted reproductive technology has made great progress during the last three decades. After the initial enthusiasm, many ethical, legal and social issues related to the application of these procedures began to evolve. Multifetal pregnancy and fetal reduction, embryo cryopreservation, preimplantation genetic diagnosis, risks of birth defects and other adverse outcome associated with assisted reproductive technology are issues that have to be addressed building future collaborative studies and continuing the debate on related ethical issues. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4156914 Thu, 11 Nov 2010 00:00:00 +0100 4156914 http://www.medworm.com/index.php?rid=4153692&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F73 Conclusion: It is concluded from the previous study that HLA-DRB1*13 may be a susceptibility allele for the occurrence of autoimmune hepatitis in our population. HLA-DRB1*07 and HLA-DRB1*15 may be susceptibility alleles for occurrence of autoimmune hepatitis type 2. HLA-DRB1*12 association with AIH in patients triggered by hepatitis A needs further studies. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4153692 Wed, 10 Nov 2010 00:00:00 +0100 4153692 http://www.medworm.com/index.php?rid=4121031&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F72 We describe the case of a teenager suffering from Systemic Lupus Erythematosus with digital ulcer resistant to conventional therapy, treated successfully with hyperbaric oxygen therapy. The application of hyperbaric oxygen, which is used for the treatment of ischemic ulcers, is an effective and safe therapeutic option in patients with ischemic vasculitic ulcers in combination with immunosuppressive drugs. Further studies are needed to evaluate its role as primary therapy for this group of patients. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4121031 Sun, 31 Oct 2010 00:00:00 +0100 4121031 http://www.medworm.com/index.php?rid=4121032&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F71 Background: Autism is a disorder of early childhood characterized by social impairment, communication abnormalities and stereotyped behaviors. The hypothalamo-pituitary-adrenocortical (HPA) axis deserves special attention, since it is the basis for emotions and social interactions that are affected in autism.AimTo assess basal and stimulated plasma cortisol, and adrenocorticotropic hormone(ACTH) levels in autistic children and their relationship to disease characteristics. Methods: Fifty autistic children were studied in comparison to 50 healthy age-, sex- and pubertal stage- matched children. All subjects were subjected to clinical evaluation and measurement of plasma cortisol (basal and stimulated) and ACTH. In addition, electroencephalography (EEG) and intelligence quotient (IQ) assessm... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4121032 Sat, 30 Oct 2010 00:00:00 +0100 4121032 http://www.medworm.com/index.php?rid=4113172&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F70 Conclusions: The present study provides preliminary evidence that fetal sonographic measurements may represent additional indices of intrauterine growth restriction. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4113172 Mon, 25 Oct 2010 23:00:00 +0100 4113172 http://www.medworm.com/index.php?rid=4092398&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F69 Conclusion: Besides diligent clinical examination, imaging and histopathology are crucial in clinching the diagnosis. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4092398 Thu, 21 Oct 2010 23:00:00 +0100 4092398 http://www.medworm.com/index.php?rid=4070362&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F68 Conclusion: Compared to surgical drainage, antibiotic management of intra-abdominal abscesses was a no invasive treatment with shorter hospitalization (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4070362 Wed, 13 Oct 2010 23:00:00 +0100 4070362 http://www.medworm.com/index.php?rid=4008213&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F65 Conclusions: Our experience, using the Vojta method, allows to affirm that this method is safe for preterm neonates, but further investigation are necessary to confirm its positive effects and to evaluate long-term respiratory outcomes. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4008213 Sat, 25 Sep 2010 23:00:00 +0100 4008213 http://www.medworm.com/index.php?rid=3978959&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F64 Corpus callosum agenesis is a relatively common brain malformation. It can be isolated or included in a complex alteration of brain (or sometimes even whole body) morphology. It has been associated with a number of neuropsychiatric disorders, from subtle neuropsychological deficits to Pervasive Developmental Disorders.Etiology and pathogenetic mechanisms have been better understood in recent years, due to the availability of more adequate animal models and the relevant progresses in developmental neurosciences. These recent findings are reviewed (through a MedLine search including papers published in the last 5 years and most relevant previously published papers) in view of the potential impact on children's global functioning and on the possible rehabilitative treatment, with an emphasis ... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3978959 Thu, 16 Sep 2010 23:00:00 +0100 3978959 http://www.medworm.com/index.php?rid=3974905&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F63 This article summarises the principal physiopathological and biochemical processes leading to necrosis and/or apoptosis of neuronal and glial cells and reports recent insights into some endogenous and exogenous cellular and molecular mechanisms aimed at repairing H-I cerebral damage. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3974905 Wed, 15 Sep 2010 23:00:00 +0100 3974905 http://www.medworm.com/index.php?rid=4083946&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F62 Leigh syndrome is a rare progressive neurodegenerative, mitochondrial disorder of childhood with only a few cases documented from India. The clinical presentation of Leigh syndrome is highly variable. However, in most cases it presents as a progressive neurological disease with motor and intellectual developmental delay and signs and symptoms of brain stem and/or basal ganglia involvement. Raised lactate levels in blood and/or cerebrospinal fluid is noted. It is the neuroimaging, mainly the Magnetic Resonance Imaging showing characteristic symmetrical necrotic lesions in the basal ganglia and/or brain stem that leads to the diagnosis. Here, we report a case of 7 months old female child presenting to us with status epilepticus, delayed developmental milestones and regression of the achieved... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=4083946 Tue, 14 Sep 2010 23:00:00 +0100 4083946 http://www.medworm.com/index.php?rid=3971133&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F62 Leigh syndrome is a rare progressive neurodegenerative, mitochondrial disorder of childhood with only a few cases documented from India. The clinical presentation of Leigh syndrome is highly variable. However, in most cases it presents as a progressive neurological disease with motor and intellectual developmental delay and signs and symptoms of brain stem and/or basal ganglia involvement. Raised lactate levels in blood and/or cerebrospinal fluid is noted. It is the neuroimaging mainly the Magnetic Resonance Imaging showing characteristic symmetrical necrotic lesions in the basal ganglia and/or brain stem that leads to the diagnosis. Here we report a case of 7 months old female child presenting to us with status epilepticus, delayed developmental milestones and regression of the achieved m... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3971133 Tue, 14 Sep 2010 23:00:00 +0100 3971133 http://www.medworm.com/index.php?rid=3963806&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F61 Conclusions: spIgE testing of children with respiratory and/or skin problems in primary care in Italy reduces over-all costs to society. The cost savings mostly result from reduction in the use of medications, particularly corticosteroids. The study indicates that spIgE testing of all children with respiratory and/or skin symptoms would be a cost-effective strategy. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3963806 Sun, 12 Sep 2010 23:00:00 +0100 3963806 http://www.medworm.com/index.php?rid=3956289&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F59 Conclusions: Most of the times, measles, mumps and rubella cause mild illness and discomfort; but can also have serious or fatal sequelae. MMR vaccination has been proved to be safe and to reduce significantly the number of reported infections due to these viruses. However, significant adverse events can occur and paediatricians and public health operators should be aware of this aspect. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3956289 Thu, 09 Sep 2010 23:00:00 +0100 3956289 http://www.medworm.com/index.php?rid=3948987&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F58 Conclusions: malaria is still an actual disease with great public health implications, and the approaches for control and prevention should have the appropriate social and political context in addition to the science involved in order to save lives of children at risk. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3948987 Wed, 08 Sep 2010 23:00:00 +0100 3948987 http://www.medworm.com/index.php?rid=3926801&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F57 During the last decades the description of autoinflammatory syndromes induced great interest among the scientific community. Mainly rheumatologists, immunologists and pediatricians are involved in the discovery of etiopathogenesis of these syndromes and in the recognition of affected patients. In this paper we will discuss the most important clues of monogenic and non-genetic inflammatory syndromes to help pediatricians in the diagnosis and treatment of these diseases. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3926801 Thu, 02 Sep 2010 23:00:00 +0100 3926801 http://www.medworm.com/index.php?rid=3874744&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F55 We report the rationale and protocol of such trial, named the "Mi voglio bene" ("I love myself") study. Methods: "Mi voglio bene" is a parallel-arm RCT. Family pediatricians willing to participate to the trial will be randomly assigned to a control group and to an experimental group. The control group will provide the usual standard of care while the experimental group will implement 10 preventive actions (promotion of breastfeeding, avoidance of solid foods, control of protein intake, avoidance of sugar-sweetened beverages, avoidance of bottle, active means of transportation, identification of early adiposity rebound, limitation of television viewing, promotion of movement, and teaching portion size) at 10 time points during a 6-yr follow-up. The main outcome measures is the prevalence of... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3874744 Mon, 16 Aug 2010 23:00:00 +0100 3874744 http://www.medworm.com/index.php?rid=3874743&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F56 The objective of the Paediatric Regulation is to improve the development of high quality and ethically researched medicines for children aged 0 to 17 years, to facilitate the availability of information on the use of medicines for children, without subjecting children to unnecessary trials, or delaying the authorisation of medicines for use in adults.SummaryThe Paediatric Regulation is dramatically changing the regulatory environment for paediatric medicines in Europe and is fuelling an increased number of clinical trials in the paediatric population. Nevertheless, there are some risks and pitfalls that need to be anticipated and controlled in order to ensure that children will ultimately benefit from this European initiative. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3874743 Mon, 16 Aug 2010 23:00:00 +0100 3874743 http://www.medworm.com/index.php?rid=3852165&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F54 Conclusion: Incomplete idRTA exist amongst children with rickets and should be looked out for in severe rickets and older children. Treatment of idRTA will lead to optimal response and healing of rickets. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3852165 Tue, 10 Aug 2010 23:00:00 +0100 3852165 http://www.medworm.com/index.php?rid=3852166&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F53 Conclusion: Prevalence of psychosocial dysfunction is higher in adolescents abusing substance compare to controls. The prevalence of psychiatric morbidity was not related to the age, gender or social classes in the study population.We advocate periodic screening of our adolescents for drug abuse regular evaluation of such group for possible psychopathology. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3852166 Mon, 09 Aug 2010 23:00:00 +0100 3852166 http://www.medworm.com/index.php?rid=3825611&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F52 IntroductionUsing the 2005 California Health Interview Survey (CHIS) data, we explore the association between excessive recreational computer use and specific food consumption behavior among California's adolescents aged 12-17. Method: The adolescent component of CHIS 2005 measured the respondents' average number of hours spent on viewing TV on a weekday, the average number of hours spent on viewing TV on a weekend day, the average number of hours spent on playing with computers on a weekday, and the average number of hours spent on playing with computers on a weekend day. We recode these four continuous variables into four variables of "excessive media use," and define more than three hours of using a medium per day as "excessive." These four variables are then used in logistic regression... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3825611 Wed, 04 Aug 2010 23:00:00 +0100 3825611 http://www.medworm.com/index.php?rid=3800851&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F51 Conclusions: Respiratory rate and erythrocyte sedimentation rates were associated with rapid decrease of fever. Anyway, none of the reported characteristics was able to predict treatment failures or delayed fever decrease in children suffering from CAP. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3800851 Wed, 28 Jul 2010 23:00:00 +0100 3800851 http://www.medworm.com/index.php?rid=3770379&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F50 We present this case of an unusual cause of mydriasis to underline once more the importance of a well and deeply conducted medical hystory. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3770379 Mon, 19 Jul 2010 23:00:00 +0100 3770379 http://www.medworm.com/index.php?rid=3735547&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F49 We have reviewed the literature related to the current advances in comprehension of Eating Disorders (ED) in childhood and preadolescence. The state of art regarding the psychodynamic models concerning the onset of ED are explained. DSM-IV and ICD-10 criteria are discussed, pointing out their little value in the characterization of early eating difficulties. Historic and new diagnostic classifications are displayed in detail. We provided a clearer description of subclinical patterns. Finally we focus on the key role of the paediatrician in detecting and managing parental concerns regarding feeding. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3735547 Wed, 07 Jul 2010 23:00:00 +0100 3735547 http://www.medworm.com/index.php?rid=3731898&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F48 Conclusions: Such a model ensures all patients to receive appropriate immunization and thus positively influencing the cost-benefit of palivizumab prophylaxis. We hope that our model of care delivery will be of use to other hospitals. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3731898 Tue, 06 Jul 2010 23:00:00 +0100 3731898 http://www.medworm.com/index.php?rid=3728319&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F47 ObjectiveTo report the outcome of children with life-threatening asthma (LTA) admitted to a university Pediatric Intensive Care Unit (PICU). Methods: Retrospective study between October 2002 and May 2010 was carried out. Every child with LTA and bronchospasm was included. Results: 30 admissions of 28 patients (13 M, 17 F) were identified which accounted for 3% of total PICU admissions (n=1033) over the study period. The majority of patients were toddlers (median age 3.1 years). Few had past history of prematurity, lung diseases, or neuro-developmental conditions. Approximately half had previous admissions for asthma and one-forth with history of non-compliance to recommended treatment for asthma. One patient had parainfluenza virus and one had rhinovirus isolated. None of these factors wer... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3728319 Mon, 05 Jul 2010 23:00:00 +0100 3728319 http://www.medworm.com/index.php?rid=3712438&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F46 The European Paediatric Regulation (EUPR) calls for the fostering of high quality ethical research and medicinal products to be used in children. The EUPR provides the background, goals, and requirements for paediatric clinical trials. Paediatric clinical trials in children are mandatory to generate data on new drugs as well as on drugs used off-label or for unlicensed indications. The Family Paediatricians Medicines for Children Research Network (FIMP-MCRN) was established in 2003 with the aim of developing competence, infrastructure, networking and education for paediatric clinical trials. The network, consisting of twenty Paediatric Regional Networks has progressed very well and has achieved valuable improvements concerning the conduct of paediatric clinical trials. Furthermore, ad hoc ... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3712438 Tue, 29 Jun 2010 23:00:00 +0100 3712438 http://www.medworm.com/index.php?rid=3654483&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F43 Ipercaloric diet and reduced physical activity have driven the rise in the prevalence of childhood obesity over a relatively short time interval. Family and twin studies have led to the conclusion that the strong predicitve value of parental body mass index (BMI) mainly stems from genetic rather than environmental factors. Whereas the common polygenic obesity arises when an individual genetic make-up is susceptible to an environment that promotes energy consumption over energy expenditure, monogenic obesity, on the contrary, is the obesity associated with a single gene mutation, which is sufficient by itself to cause weight gain in a food abundant context. Genes involved in the leptin-melanocortin pathway are often mutated in these cases. The cumulative prevalence of monogenic obesity amon... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3654483 Thu, 10 Jun 2010 23:00:00 +0100 3654483 http://www.medworm.com/index.php?rid=3601731&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F41 Hepatic hemangioma, adenoma and focal nodular hyperplasia are the most frequent benign lesions of the liver, but they are all infrequent among paediatric population. The reports of focal nodular hyperplasia in children have recently increased in number, with many cases associated to drug intake, particularly to chemotherapy. We here describe, to our knowledge, the first case of focal nodular hyperplasia in association with diabetes mellitus in childhood. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3601731 Tue, 25 May 2010 23:00:00 +0100 3601731 http://www.medworm.com/index.php?rid=3597723&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F39 Conclusions: Our data confirm high frequency of glomerular and tubular dysfunctions in TD-BTM pediatric patients which could be attributed to oxidative stress and DFO therapy. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3597723 Mon, 24 May 2010 23:00:00 +0100 3597723 http://www.medworm.com/index.php?rid=3597722&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F40 This study was realized with a sample of caregivers of children hospitalized for mild acute diseases. Research was conducted using two standardized tests, PSM (Psychological Stress Measure) and STAI (State Trait Anxiety Inventory), whose characteristics of reliability and validity had been successfully established. Results: Present data showed that caregivers of hospitalized children perceived high levels of stress and anxiety. Perception of stress was influenced by the degree of kindred with patients, length of hospitalization, and, notably, participation in some of the activities offered to children, mainly school services.DiscussionFindings showed that child hospitalization is a stressful event for caregivers, even if hospitalization is for middle and transient pathologies. Perception o... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3597722 Mon, 24 May 2010 23:00:00 +0100 3597722 http://www.medworm.com/index.php?rid=3575491&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F38 We report for the first time the association of liver failure with porto-pulmonary hypertension secondary to NH in an infant with Trisomy 21. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3575491 Mon, 17 May 2010 23:00:00 +0100 3575491 http://www.medworm.com/index.php?rid=3562352&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F37 Conclusion: Significant behavioral problems occur co-morbidly among Nigerian children with intellectual disability receiving special education instructions and this could impact negatively on educational learning and other areas of functioning. There is an urgent need for establishing school-based mental health program and appropriate screening measure in this environment. These would afford early identification of intellectually disabled children with behavioral problems and appropriate referral for clinical evaluation and interventions. The need to focus policy making attention on hidden burden of intellectual disability in sub-Saharan African children is essential. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3562352 Wed, 12 May 2010 23:00:00 +0100 3562352 http://www.medworm.com/index.php?rid=3496308&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F34 We report the case of a 17 year-old boy with two week history of fever and enlarged cervical lymph nodes firstly misdiagnosed as Epstein-Barr Virus (EBV) infection, subsequently diagnosed as Burkitt's Lymphoma and vertical HIV infection. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3496308 Thu, 22 Apr 2010 23:00:00 +0100 3496308 http://www.medworm.com/index.php?rid=3489010&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F33 Background: Despite the development and dissemination of guidelines for the diagnosis and management of asthma, a gap remains between current recommendations and actual practice.Objectives: To assess the physicians attitude towards asthma guidelines and their adherence to its recommendations. Methods: Three hundred and fifty two clinicians (101 General practitioners, 131 pediatric specialists, 35 pediatric consultants and 85 doctors did not report the qualification) engaged in direct childhood asthma care in Cairo, Egypt were subjected to a self-administered questionnaire with 35 questions of which most were multiple choices, aiming at assessment of three important aspects about the involved physicians; physician's knowledge, practice and attitude. 165 of the clinicians were working in gov... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3489010 Tue, 20 Apr 2010 23:00:00 +0100 3489010 http://www.medworm.com/index.php?rid=3489011&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F32 The objective of the study was to evaluate these angiogenic factors VEGF, PD-ECGF/TP and leptin in children with congenital heart disease (CHD) and the factors that lead to angiogenesis in such cases. Methods: Sixty CHD children were studied and divided into two groups (n=30); cyanotic-CHD (C-CHD) and acyanotic-CHD (A-CHD). Twenty five healthy children were included as controls. Results: Significantly higher serum levels of VEGF, PD-ECGF/TP activity and leptin were detected in patients with CHD, particularly in patients with C-CHD. CHD patients with SpO2 (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3489011 Mon, 19 Apr 2010 23:00:00 +0100 3489011 http://www.medworm.com/index.php?rid=3478685&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F31 Angelman syndrome (AS) is a neuro-behavioural, genetically determined condition, characterized by ataxic jerky movements, happy sociable disposition and unprovoked bouts of laughter in association with seizures, learning disabilities and language impairment. Most of the cases are hardly diagnosed during infancy as jerky movements, the cardinal sign, appear later in childhood.AS is caused by a variety of genetic mechanisms involving the 15q 11-13 chromosome. About 70% of cases are due to a "de novo" interstitial deletion in the long arm region, arising on the maternally inherited chromosome. The diagnosis is confirmed by methylation test or by mutation analysis of UBE3A gene. The deletion phenotype is generally linked to a more severe clinical picture in that 95% of patients manifest more s... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3478685 Thu, 15 Apr 2010 23:00:00 +0100 3478685 http://www.medworm.com/index.php?rid=3470015&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F30 Conclusions Our small experience seems to confirm the efficacy and safety of VNS in drug resistant partial and generalized epilepsy in developing age groups. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3470015 Tue, 13 Apr 2010 23:00:00 +0100 3470015 http://www.medworm.com/index.php?rid=3458984&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F29 We report an unusual case of a 3-year-old boy affected by A-T who presented exclusively with extensive cutaneous granulomatosis and severe combined immunodeficiency, without neurological abnormalities, at the time of diagnosis. This case clearly emphasizes the variable presentation of A-T syndrome and highlights the difficulties in the early diagnosis of A-T.A-T should be considered in children with evidence of combined humoral and cellular immunodeficiency associated with unexplained skin granulomatous lesions, even in the absence of the classic features of this syndrome. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3458984 Sat, 10 Apr 2010 23:00:00 +0100 3458984 http://www.medworm.com/index.php?rid=3406436&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F28 Conclusions: Vaccination rates in children with chronic conditions were poor for pneumococcus and slightly better for influenza. Barriers to vaccination include lack of awareness, health care and organization problems. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3406436 Fri, 26 Mar 2010 00:00:00 +0100 3406436 http://www.medworm.com/index.php?rid=3384599&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F27 Two premature twins (33 weeks gestation) were born to a woman who had used paroxetine during pregnancy for an anxiety-depression disorder. They were admitted to the NICU, where they showed prolonged RDS, cardiovascular malformations, and facial dysmorphisms. Soon after birth, they also presented abnormal neurobehavioral and motor signs, which partially disappeared during the following weeks, although alterations of tone persisted even at discharge.Selective serotonin reuptake inhibitor (SSRI) antidepressants are considered the primary treatments for depression and anxiety in pregnancy. Since intrauterine exposure to these drugs has been associated with poor neonatal adaptation, low birth weight, RDS, neurobehavioural symptoms, and potential teratogenic effects, further studies are needed t... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3384599 Fri, 19 Mar 2010 00:00:00 +0100 3384599 http://www.medworm.com/index.php?rid=3381120&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F26 Background: The control of growth and nutritional status in the foetus and neonate is a complex mechanism, in which also hormones produced by adipose tissue, such as adiponectin and leptin are involved. The aim of this study was to evaluate levels of adiponectin, leptin and insulin in appropriate (AGA) and small for gestational age (SGA) children during the 1st year of life and to correlate these with auxological parameters. Methods: In 33 AGA and 29 SGA infants, weight, length, head circumference, glucose, insulin, adiponectin and leptin levels were evaluated at the second day of life, and at one, six and twelve months, during which a portion of SGA could show catch-up growth (rapid growth in infants born small for their gestational age). Results: Both total and isoform adiponectin levels... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3381120 Thu, 18 Mar 2010 00:00:00 +0100 3381120 http://www.medworm.com/index.php?rid=3376402&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F25 Conclusions: IgA-AAA may be undetectable in presence of severe mucosal damage. Histology is still necessary to diagnose celiac disease and IgA-AAA cannot be included in usual screening tests, because it has little to offer if compared to the well-established tTG-Ab.IgA-AAA could be an adjunctive, very useful tool to support the diagnosis of CD in case of suboptimal histology, when the biopsy is to be avoided for clinical reasons, or in case of negative parents' consensus. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3376402 Thu, 18 Mar 2010 00:00:00 +0100 3376402 http://www.medworm.com/index.php?rid=3352427&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F24 Conclusions: Transient mild elevation of serum TSH above the normal reference value for age is frequently observed in the first month of life in infants born from mother affected by autoimmune thyroiditis. Persistent hyperthyrotropinemia requiring replacement therapy is observed in 2.2% of these neonates. According to our experience, follow-up is recommended in these newborns; the most accurate and not invasive way to careful monitor these infants after neonatal screening for CH seems to be serum-testing TSH between 2 nd and 4 th week of life. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3352427 Wed, 10 Mar 2010 00:00:00 +0100 3352427 http://www.medworm.com/index.php?rid=3345020&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F23 A male infant born by caesarean section at 38 weeks of gestational age (B.W. 4055g; Apgar 9-10), in the first two hours of life his right leg became hypovascularizated.Normal values of leukocities, red cells, haematocrit, hemoglobin, platelets. C-Reactive Protein negative. Electrolytes and coagulation tests were normal. Normal vitamin K coagulation proteins levels. Serological tests for TORCH (IgM) and Parvovirus (IgG and IgM) were negative.Sonography showed a reduced blood flow in the iliac artery and reported a 1 cm long vessel thrombosis.From 8 hours of life we administred an intravenous infusion of unfractionated heparin (UFH) 75 UI/Kg for the first 10 minutes then 28 UI/Kg/h.On the 2nd day tests were performed to assess absence of inhibiting-clot factors. The dosage of homocysteine, p... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3345020 Mon, 08 Mar 2010 00:00:00 +0100 3345020 http://www.medworm.com/index.php?rid=3286031&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F20 We focus on themes that are derived from clinical practice and research in the field of genetic diseases of bone and inborn errors of metabolism but may be of more general interest as they indicate some trends in molecular medicine as related to pediatrics. Identifying the disease-causing mechanism brings about efficient therapeutic strategies and discovering the mutant genotype in the near future may become helpful for devising custom-built molecular responses. At the same time, the transition of therapy from the experimental phase to industrial application is difficult as there may be novel roles (and potentially conflicting interests) between physicians, patient organisations, governmental agencies and the pharmaceutical industry. Awareness of these potential conflicts may help in recog... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3286031 Fri, 19 Feb 2010 00:00:00 +0100 3286031 http://www.medworm.com/index.php?rid=3257005&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F16 Conclusion: This study demonstrated that CD is prevalent among schoolchildren in Jordan. The seropositive children tend to have lower height, weight, and BMI than the seronegative group. These differences were significant only for boys. None of the participants is known to have CD prior to the study. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3257005 Tue, 09 Feb 2010 00:00:00 +0100 3257005 http://www.medworm.com/index.php?rid=3252822&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F15 This epileptic disorder has become a classic topic for neuropediatricians and the interest is documented by the large number of publications on this subject.The relative frequency among the epileptic syndromes is an another reason why not only neuropediatricians but also general pediatricians must be fully informed about diagnostic, clinical, imaging and genetic aspects.Early diagnosis is of paramount importance in order to obtain even complete results in patients with so called idiopathic situations. A number of problems are still to be solved. There is no agreement on the type and the schedule of treatment. A common denominator about this problem is not jet available even if some advances in this regard have been accomplished. Of paramount importance is an accurate clinical and laborator... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3252822 Mon, 08 Feb 2010 00:00:00 +0100 3252822 http://www.medworm.com/index.php?rid=3241955&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F13 Conclusions: GAG excretion in patients with PNE was significantly higher than in normal children, suggesting that measurement of urinary GAG may be useful in evaluating physiopathological conditions of the bladder wall. Further studies are needed to confirm this finding. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3241955 Wed, 03 Feb 2010 00:00:00 +0100 3241955 http://www.medworm.com/index.php?rid=3229784&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F12 Conclusions: The Pitt-Hopkins syndrome should be suspected on the basis of clinical features. Nowadays this syndrome results widely underdiagnosed and searching for TCF4 mutations is recommended when others overlapping syndromes are excluded.At our knowledge our patient is the first italian case of PHS diagnosed at molecular level. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3229784 Tue, 02 Feb 2010 00:00:00 +0100 3229784 http://www.medworm.com/index.php?rid=3222179&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F10 Conclusions: To rationalize research efforts and find better tailored therapies, we need to improve PDD classification systems, using contributions coming from every field of child psychiatry and neurology: it's possible that 0-3 Classification could help this. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3222179 Fri, 29 Jan 2010 00:00:00 +0100 3222179 http://www.medworm.com/index.php?rid=3206948&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F9 Background: In order to estimate the causes of pediatric morbidity in our area, with particular emphasis on diseases with a genetic background, we retrospectively categorized the admissions of all children hospitalized in the Department of Pediatrics of the University General Hospital of Alexandroupolis, in the area of Evros, Thrace, Greece over the three year period 2005-2007. Finally, in order to guide health care administrators to improve the delivery of pediatric health care services, we estimated the percentage of hospitalized children who were uninsured and the type of health insurance of those who had medical coverage.Patients and Methods: The causes of admission, as recorded in the medical records were categorized in terms of the major organ and/or system involved and/or the underl... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3206948 Tue, 26 Jan 2010 00:00:00 +0100 3206948 http://www.medworm.com/index.php?rid=3195972&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F8 Obesity is a multi-factorial disease, resulting from genes, environment and behaviour interactions, and represents the most common metabolic disorder in the Western Hemisphere. Its prevalence has dramatically risen during the last three decades, reaching worldwide epidemic proportions. Recent cumulating evidence suggests that obesity may represent an adverse health consequence of exposure during the critical developmental windows to environmental chemicals disrupting endocrine function. Moreover, exposure to these chemicals seems to play a key role in the development of obesity-related metabolic and cardiovascular diseases. Further research is needed to elucidate the relationship between this exposure and the obesity pandemia and the involved mechanisms as well as to refine hazard identifi... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3195972 Fri, 22 Jan 2010 00:00:00 +0100 3195972 http://www.medworm.com/index.php?rid=3187502&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F7 A 3yr old boy presented with abdominal pain, fever and red jelly stools. Intussusception was diagnosed and effectively reduced with air insufflation. However, despite an improvement in his clinical condition, the child remained febrile and miserable; 5 days later he developed characteristic signs of Kawasaki disease and was treated with intravenous immunoglobulin and high dose aspirin with good results. Intussusception prior to the typical features of Kawasaki disease has not been described previously in the English literature. This case illustrates a novel presentation of Kawasaki disease. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3187502 Tue, 19 Jan 2010 00:00:00 +0100 3187502 http://www.medworm.com/index.php?rid=3184144&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F6 Conclusions: Perfusion index proved to be an easily applicable, non-invasive method for monitoring early postnatal changes in peripheral perfusion. Its trend during the first week of life suggests that its clinical application should take age into account. Further studies are needed to obtain reference perfusion index values from a larger sample of preterm newborns, to identify specific gestational age-related cut-off values for illness and to test the role of perfusion index in monitoring critically ill neonates. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3184144 Mon, 18 Jan 2010 00:00:00 +0100 3184144 http://www.medworm.com/index.php?rid=3174096&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F4 Many medicines are prescribed to the paediatric population on an unlicensed or 'off-label' basis because they have not been adequately tested and/or formulated and authorized for use in appropriate paediatric age groups.Regulatory authorities also need to remind health professionals about the importance of their contribution towards the process of paediatric pharmacovigilance thanks to their reporting of adverse drug reactions.The lack of reliable data in the paediatric population is associated with specific problems including: limited availability of safety data due to the lack of clinical trials in the paediatric population; underor over-dosing in some age groups due to the lack of pharmacokinetics data or dose-finding studies; maturation, growth and development of the paediatric populat... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3174096 Fri, 15 Jan 2010 00:00:00 +0100 3174096 http://www.medworm.com/index.php?rid=3174097&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F3 We describe the neonatal course of a peculiar case of type 1 pyloric atresia, in which the pyloric membrane was connected to a second duodenal membrane through a virtual duodenal lumen in a premature newborn. The atypical variant required an unusual side to side gastroduodenostomy. We emphasize the importance of a prompt diagnosis to avoid potentially fatal complications and to warrant a good outcome even in the presence of a strange form of PA in the neonatal period. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3174097 Thu, 14 Jan 2010 00:00:00 +0100 3174097 http://www.medworm.com/index.php?rid=3169556&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F2 This study also provides an overview of the most common allergens in pediatric population and discusses various therapeutic modalities. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3169556 Wed, 13 Jan 2010 00:00:00 +0100 3169556 http://www.medworm.com/index.php?rid=3140942&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F36%2F1%2F1 We describe a case of congenital afibrinogenemia which presented as an antenatally detected intracranial bleed. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3140942 Tue, 05 Jan 2010 00:00:00 +0100 3140942 http://www.medworm.com/index.php?rid=3127991&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F35%2F1%2F44 This study represents a major breakthrough in the cure of otherwise fatal leukemias, providing information on the best criteria for choosing the optimal donor. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3127991 Wed, 30 Dec 2009 00:00:00 +0100 3127991 http://www.medworm.com/index.php?rid=3117346&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F35%2F1%2F43 Among the preschool children who wheeze two different groups can be identify: children who have a viral infection and those who respond to multiple triggers, such as exercise or allergens.To distinguish between these different phenotypes of wheezing, and consequently choose therapy represents a major challenge for pediatricians.Transient wheezers conditions do not improve with maintenance treatment with ICS. On the other hand they are definitely useful in children with wheeze/asthma.Increasing evidence is in favor of the potential role of leukotriene receptor antagonists in preschool children with recurrent wheezing.Oral steroid has been demonstrated not to be indicated to control acute wheezing, unless severe disease is expected in non-atopic children.The early phenotyping of preschool wh... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3117346 Thu, 24 Dec 2009 00:00:00 +0100 3117346 http://www.medworm.com/index.php?rid=3028445&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F35%2F1%2F38 This study was done to assess the relationship between physical fighting and bullying victimization among Venezuelan school-going adolescents in Barinas.MethodWe used data from the 2003 Global School-Based Health Survey conducted among in-school adolescents in Barinas, Venezuela. We estimated the prevalence of bullying victimization and physical fighting. We also conducted Logistic regression analysis to assess the association between a selected list of explanatory variables and physical fighting. We hypothesized that there would be a dose-response relationship between physical fighting and number of times the adolescent reported being a bullied in the past 30 days. Results: A total of 2,249 adolescent students participated in the survey. However data on sex (gender) were available for onl... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3028445 Wed, 25 Nov 2009 00:00:00 +0100 3028445 http://www.medworm.com/index.php?rid=3014276&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F35%2F1%2F37 This article reports possible subcellular molecular alterations of anthracycline-induced cardiomyopathy (reactive oxygen species formation, apoptosis, inflammatory signalling, altered expression of cardiomyocytes specific genes, etc) and indicates some new therapeutic perspectives resulting from a better understanding of the molecular pathogenetic mechanisms. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3014276 Fri, 20 Nov 2009 00:00:00 +0100 3014276 http://www.medworm.com/index.php?rid=3010740&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F35%2F1%2F36 There is a high frequency of diarrhea and vomiting in childhood. As a consequence the focus of the present review is to recognize the different body fluid compartments, to clinically assess the degree of dehydration, to know how the equilibrium between extracellular fluid and intracellular fluid is maintained, to calculate the effective blood osmolality and discuss both parenteral fluid requirments and repair. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3010740 Thu, 19 Nov 2009 00:00:00 +0100 3010740 http://www.medworm.com/index.php?rid=3002143&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F35%2F1%2F35 Conclusions: Stump appendicitis is rare and should be considered in any patient with right lower quadrant pain even if there is a history of appendectomy. Complete removal of the appendix is the only mean to prevent the occurrence of this complication. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=3002143 Tue, 17 Nov 2009 00:00:00 +0100 3002143 http://www.medworm.com/index.php?rid=2983413&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F35%2F1%2F34 The role of infectious agents in autoimmune diseases has been the subject of several studies and is still under investigation. Here a paediatric case series of autoimmune uveitis is reported. An exacerbation of the ocular inflammation occurred in concomitance with nasal colonisation by Staphylococcus aureus (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=2983413 Thu, 12 Nov 2009 00:00:00 +0100 2983413 http://www.medworm.com/index.php?rid=2961547&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F35%2F1%2F33 Conclusion: PCT is not a good screening test for identifying skeletal infection in children. Larger studies are needed to evaluate still more the place of PCT measurements in the diagnosis of osteomyelitis and septic arthritis. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=2961547 Wed, 04 Nov 2009 00:00:00 +0100 2961547 http://www.medworm.com/index.php?rid=2937037&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F35%2F1%2F32 Conclusions: PD is common in the average population. Using a simple and standardized instrument, pediatricians are able to detect parents with higher risk of suffering from PD. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=2937037 Wed, 28 Oct 2009 00:00:00 +0100 2937037 http://www.medworm.com/index.php?rid=2918400&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F35%2F1%2F30 In many fields of medicine there is a growing interest in characterizing diseases at molecular level with a view to developing an individually tailored therapeutic approach. Metabolomics is a novel area that promises to contribute significantly to the characterization of various disease phenotypes and to the identification of personal metabolic features that can predict response to therapies. Based on analytical platforms such as mass spectrometry or NMR-based spectroscopy, the metabolomic approach enables a comprehensive overview of the metabolites, leading to the characterization of the metabolic fingerprint of a given sample. These metabolic fingerprints can then be used to distinguish between different disease phenotypes and to predict a drug's effectiveness and/or toxicity.Several stu... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=2918400 Thu, 22 Oct 2009 23:00:00 +0100 2918400 http://www.medworm.com/index.php?rid=2795046&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F35%2F1%2F28 Intestinal Failure is a permanent loss of digestive and absorptive functions as a consequence of short bowel syndrome and/or other primary intestinal conditions. Patients with intestinal failure (IF) require long term parenteral nutrition to survive. The only alternative to parenteral nutrition is intestinal transplantation which still entails high mortality. Children with intestinal failure on parenteral nutrition may develop liver failure (LF),as a consequence of central line infections and other conditions. In children with both irreversible IF and LF a combined transplantation is generally considered. Despite low survival rate, combined liver/intestine transplantation is associated to better intestinal graft survival and lower incidence and severity of rejection compared to isolated sm... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=2795046 Mon, 14 Sep 2009 23:00:00 +0100 2795046 http://www.medworm.com/index.php?rid=2773704&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F35%2F1%2F27 "Dravet syndrome" (DS) previously named severe myoclonic epilepsy of infancy (SMEI), or epilepsy with polymorphic seizures, is a rare disorder characterized by an early, severe, generalized, epileptic encephalopathy.DS is characterized by febrile and afebrile seizures beginning in the 1st year of life followed by different types of seizures ( either focal or generalized), which are typically resistant to antiepileptic drugs. A developmental delay from the 2nd to 3rd year of life becomes evident, together with motor disturbances and personality disorders.Beside the classic syndrome, there are milder cases which have been called severe myoclonic epilepsy borderline (SMEB).DS is caused by a mutation in the neuronal sodium channel gene, SCN1A, that is also mutated in generalized epilepsy with ... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=2773704 Mon, 07 Sep 2009 23:00:00 +0100 2773704 http://www.medworm.com/index.php?rid=2677087&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F35%2F1%2F24 Conclusions: Chest high-field 3T MRI appears to be as effective as HRCT in assessing the extent and severity of lung abnormalities in PCD. MRI scores might be used for longitudinal assessment and be an outcome surrogate in future studies. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=2677087 Wed, 05 Aug 2009 23:00:00 +0100 2677087 http://www.medworm.com/index.php?rid=2659477&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F35%2F1%2F23 Recent studies suggest a link between type 1 diabetes mellitus and pervasive developmental disorder. Moreover, permanent neonatal diabetes mellitus due to pancreatic agenesis can be associated with neurological deficit involving cerebellar functions, but no association with pervasive developmental disorder has been described so far. Clinical and neuropsychological evaluation of a child with pancreatic agenesis, mental retardation and pervasive developmental disorder is reported. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=2659477 Thu, 30 Jul 2009 23:00:00 +0100 2659477 http://www.medworm.com/index.php?rid=2618731&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F35%2F1%2F21 Fractional exhaled nitric oxide (FeNO) is a useful tool to diagnose and monitor eosinophilic bronchial inflammation in asthmatic children and adults. In children younger than 2 years of age FeNO has been successfully measured both with the tidal breathing and with the single breath techniques. However, there are a number of methodological issues that need to be addressed in order to increase the reproducibility of the FeNO measurements within and between infants. Indeed, a standardized method to measure FeNO in the first 2 years of life would be extremely useful in order to meaningfully interpret FeNO values in this age group. Several factors related to the measurement conditions have been found to influence FeNO, such as expiratory flow, ambient NO and nasal contamination. Furthermore, th... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=2618731 Sun, 19 Jul 2009 23:00:00 +0100 2618731 http://www.medworm.com/index.php?rid=2618730&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F35%2F1%2F22 Conclusion: Antibodies to chromatin may be superior to those to soluble liver antigen in predicting relapse and may be useful as prognostic marker. Further studies with larger number of patients and combined testing of more than one antibody will improve the performance parameters of these antibodies and define optimal testing conditions for them before they can be incorporated into management algorithms that project prognosis. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=2618730 Sun, 19 Jul 2009 23:00:00 +0100 2618730 http://www.medworm.com/index.php?rid=2600094&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F35%2F1%2F20 This article reviews the pathophysiology of foetal and neonatal bone metabolism, focuses on the nutrient requirements of premature babies and on the ways to early detect and treat osteopenia. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=2600094 Mon, 13 Jul 2009 23:00:00 +0100 2600094 http://www.medworm.com/index.php?rid=2582566&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F35%2F1%2F19 Conclusion: Our data confirm the high rate of AM tolerability in children with moderate symptoms of CMPA. Moreover, we found that AM seems to have nutritional adequacy in subjects with a varied diet. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=2582566 Wed, 08 Jul 2009 23:00:00 +0100 2582566 http://www.medworm.com/index.php?rid=2519509&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F35%2F1%2F17 Conclusions: The incidence of bifid T waves in leads V2 and V3 in normal children is high, and awareness of this phenomenon avoids possible misinterpretations leading to a diagnosis of ECG abnormalities. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=2519509 Thu, 25 Jun 2009 23:00:00 +0100 2519509 http://www.medworm.com/index.php?rid=2516397&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F35%2F1%2F16 Conclusions: Emergent wheezing illnesses during childhood can be linked to infection with rhinovirus in Trinidad's tropical environment. Viral-induced exacerbations of asthma are independent of seasons in this tropical climate. Further clinical and virology investigations are recommended on the role of infections with the rhinovirus in Caribbean childhood wheeze. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=2516397 Wed, 24 Jun 2009 23:00:00 +0100 2516397 http://www.medworm.com/index.php?rid=2493968&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F35%2F1%2F15 Conclusion: Our preliminary data set the base to further evaluate the implementation of a primary stroke prevention program in our setting of HbS/HbS African immigrants and HbS/beta thalassemia Italians. Parental education -preferably in the native language- on stroke risk and prevention in SCD increases compliance and should be a necessary part of the program. Ethnic background does not seem to influence TCD velocity and internationally accepted reference values already validated in African-American SCD pediatric patients can be used, but long prospective trials are needed to verify their efficacy in defining stroke risk in our setting. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=2493968 Sun, 21 Jun 2009 23:00:00 +0100 2493968 http://www.medworm.com/index.php?rid=2461309&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F35%2F1%2F14 Background: The issue concerning neurologic outcome in patients with perinatal Hypoxic-Ischemic Encephalopathy (H.I.E) has inspired many studies which tried to identify adequate prognostic factors. Our work aims to find among neonatal parameters:-factors which help to predict the risk to develop both Cerebral Palsy (CP) and secondary Epilepsy at one year of age in subjects affected by perinatal Hypoxic-Ischemic Encephalopathy,-correlations between the neonatal parameters and the variable severity of above mentioned sequelae. Methods: We have recruited 32 subjects, whose history and neuroimages suggested a perinatal H.I.E and we have retrospectively analysed clinical-instrumental parameters at birth and at one year of age. Results: At one year cut-off, 9 patients developed both secondary ep... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=2461309 Thu, 04 Jun 2009 04:00:00 +0100 2461309 http://www.medworm.com/index.php?rid=2409663&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F35%2F1%2F12 DiscussionThe concepts of family-centered and family-oriented care are discussed with the aim to emphasize their importance in pediatrics. Notions related to family-centered care, such as cultural diversity and cultural competence, are also discussed given the importance they have gained following the recent transformations of socioeconomic, demographic and ethnic characteristics of economically advantaged Countries. Family-centered care has developed as a result of the increased awareness of the importance of meeting the psychosocial and developmental needs of children and of the role of families in promoting the health and well-being of their children. Family-oriented care aims at extending the responsibilities of the pediatrician to include screening, assessment, and referral of parents... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=2409663 Tue, 12 May 2009 04:00:00 +0100 2409663 http://www.medworm.com/index.php?rid=2384928&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F35%2F1%2F10 We report the case of a female preterm infant with extensive PF due to group B streptococcus (GBS) septicemia. She developed multi-organ system failure despite neonatal intensive care support and succumbed 9 days later. GBS, sensitive to penicillin, was isolated from the blood cultures of the mother and the infant. Invasive early GBS infection is common in the newborn and is empirically treated with prompt institution of intravenous antibiotics. PF associated with GBS is a rare cutaneous sign that must not be missed. Mortality remains high despite aggressive treatment and ICU support. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=2384928 Thu, 30 Apr 2009 04:00:00 +0100 2384928 http://www.medworm.com/index.php?rid=2371947&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F35%2F1%2F9 Background: Mental retardation affects approximately 1 to 3% of the general population. The etiology is still poorly understood and it is estimated that one-half of the cases are due to genetic factors. Cryptic subtelomeric aberrations have been found in roughly 5 to 7% of all cases. Methods: We performed a subtelomeric FISH analysis of 76 unrelated children with normal standard karyotype ascertained by developmental delay or mental retardation, associated with congenital malformations, and/or facial dysmorphisms. Results: Ten cryptic chromosomal anomalies have been identified in the whole cohort (13,16%), 8 in the group of patients characterized by developmental delay or mental retardation associated with congenital malformations and facial dysmorphisms, 2 in patients with developmental... Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=2371947 Mon, 27 Apr 2009 04:00:00 +0100 2371947 http://www.medworm.com/index.php?rid=2336055&cid=s_38186_33_f&fid=38186&url=http%3A%2F%2Fwww.ijponline.net%2Fcontent%2F35%2F1%2F6 Conclusion: In preterm healthy newborns of 34 weeks gestational age, electrical and motor activity are completely developed at birth whilst the intestinal epithelial barrier clearly improves during the first week of life. (Source: Italian Journal of Pediatrics) Italian Journal of Pediatrics journals http://www.medworm.com/rss/comments.php?id=2336055 Sun, 15 Mar 2009 04:00:00 +0100 2336055