MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'J Korean Med Sci' source. Wed, 08 Feb 2012 18:50:22 +0100 http://www.medworm.com/index.php?rid=5570351&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22219605%26dopt%3DAbstract Authors: Lim JH PMID: 22219605 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5570351 Sun, 01 Jan 2012 05:00:00 +0100 5570351 http://www.medworm.com/index.php?rid=5570350&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22219606%26dopt%3DAbstract In conclusion, our results suggest that the toxicity of surfactants be taken care of pertinent treatment of acute herbicide intoxication. PMID: 22219606 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5570350 Sun, 01 Jan 2012 05:00:00 +0100 5570350 http://www.medworm.com/index.php?rid=5570349&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22219607%26dopt%3DAbstract This study suggests that the serial monitoring of RTi-NASBA could be useful for prediction of the clinical outcome in hematologic patients with IA. PMID: 22219607 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5570349 Sun, 01 Jan 2012 05:00:00 +0100 5570349 http://www.medworm.com/index.php?rid=5570348&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22219608%26dopt%3DAbstract The objective of this study was to examine the prevalence and risk factors for widespread pain and its influence on quality of life in residents of Korean communities. A rural and an urban community were selected, and 5,037 subjects were surveyed. Participants were asked if they had pain, aching, or stiffness in any of their joints on most days. Widespread pain was defined as pain above the waist, below the waist, on both sides of the body and in the axial region. The prevalence of widespread pain was 12% (16.2% and 5.5% in females and males, respectively). It was more frequent among females and increased with age in both genders. Age, female gender, and the presence of hand or knee arthritis were significantly associated with widespread pain after multivariate analysis. Except for mental ... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5570348 Sun, 01 Jan 2012 05:00:00 +0100 5570348 http://www.medworm.com/index.php?rid=5570345&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22219609%26dopt%3DAbstract Authors: Kim HA, Lee J, Ha YJ, Kim SH, Lee CH, Choi HJ, Baek HJ, Lim MJ, Park W, Choi S, Hong YS, Lee YH, Koh BR, Suh CH Abstract Polymyalgia rheumatica is an inflammatory disease affecting elderly and involving the shoulder and pelvic girdles. No epidemiological study of polymyalgia rheumatica was conducted in Korea. We retrospectively evaluated patients with polymyalgia rheumatica followed up at the rheumatology clinics of 10 tertiary hospitals. In total 51 patients, 36 patients (70.6%) were female. Age at disease onset was 67.4 yr. Twenty-three patients (45.1%) developed polymyalgia rheumatica in winter. Shoulder girdle ache was observed in 45 patients (90%) and elevated erythrocyte sedimentation rate (> 40 mm/h) in 49 patients (96.1%). Initial steroid dose was 23.3 mg/d pred... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5570345 Sun, 01 Jan 2012 05:00:00 +0100 5570345 http://www.medworm.com/index.php?rid=5570344&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22219610%26dopt%3DAbstract We report that B-1a cells preferentially migrate out of the peritoneal cavity and upregulate the expression of CXCR4 with heightened sensitivity to CXCL12 and CXCL13 upon LPS treatment compared to B-1b and B-2 cells. Whereas B-1a cells were slightly more abundant than B-1b and B-2 cells in the homeostatic condition, the number of B-1a cells preferentially decreased 48 hr after LPS treatment. The decrease in the peritoneal B-1a cell number was accompanied with increased migration of B-1a cells toward CXCL-12 and CXCL-13 in in vitro transmigration assay using peritoneal B cells from LPS treated mice. The expression level of CXCR4, but not of CXCR5, was also more prominently increased in B-1a cells upon LPS stimulation. LPS-stimulated B-1a cells did not accumulate in omental milky spots in co... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5570344 Sun, 01 Jan 2012 05:00:00 +0100 5570344 http://www.medworm.com/index.php?rid=5570343&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22219611%26dopt%3DAbstract This study demonstrated that three specimens were sufficient to make correct pathologic diagnoses in advanced gastrointestinal cancer. Therefore, we recommend 3 or 4 biopsies from viable tissue in advanced gastrointestinal cancer to make a pathologic diagnosis during endoscopy. PMID: 22219611 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5570343 Sun, 01 Jan 2012 05:00:00 +0100 5570343 http://www.medworm.com/index.php?rid=5570342&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22219612%26dopt%3DAbstract Authors: Park KK, Lee SH, Choi YD, Chung BH Abstract The present study evaluated optimal baseline prostate-specific antigen (PSA) level at different ages in order to determine the risk of developing prostate cancer (CaP). We analyzed 6,651 Korean men, aged 40-69 yr. The serum PSA levels for these men were measured at one institute from 2000 to 2004 and were determined to be between 0-4 ng/mL. Patients were divided into 4 groups of 25th-percentile intervals, based on initial PSA level. Of these, the group with an increased risk was selected, and the optimal value was determined by the maximal area under a receiver-operating characteristic curve within the selected group. The risk of CaP diagnosis was evaluated by Cox regression. The mean follow-up period was 8.3 yr. CaP was detected... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5570342 Sun, 01 Jan 2012 05:00:00 +0100 5570342 http://www.medworm.com/index.php?rid=5570341&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22219613%26dopt%3DAbstract Authors: Jhun BW, Park HY, Jeon K, Koh WJ, Suh GY, Chung MP, Kim H, Kwon OJ, Han J, Um SW Abstract There are no accurate data on the relationship between nodal station and diagnostic performance of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). We evaluated the impact of nodal station and size on the diagnostic performance of EBUS-TBNA in patients with non-small cell lung cancer (NSCLC). Consecutive patients who underwent EBUS-TBNA of mediastinal or hilar lymph nodes for staging or diagnosis of NSCLC were included in this retrospective study. Between May 2009 and February 2010, EBUS-TBNA was performed in 373 mediastinal and hilar lymph nodes in 151 patients. The overall diagnostic sensitivity, specificity, accuracy and negative predictive value (NPV) ... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5570341 Sun, 01 Jan 2012 05:00:00 +0100 5570341 http://www.medworm.com/index.php?rid=5570340&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22219614%26dopt%3DAbstract Authors: Joe BH, Jo U, Kim HS, Park CB, Hwang HJ, Sohn IS, Jin ES, Cho JM, Park JH, Kim CJ Abstract While the disease course of stress-induced cardiomyopathy (SIC) is usually benign, it can be fatal. The prognostic factors to predict poorer outcome are not well established, however. We analyzed the Acute Physiology And Chronic Health Evaluation (APACHE) II score to assess its value for predicting poor prognosis in patients with SIC. Thirty-seven consecutive patients with SIC were followed prospectively during their hospitalization. Clinical factors, including APACHE II score, coronary angiogram, echocardiography and cardiac enzymes at presentation were analyzed. Of the 37 patients, 27 patients (73%) were women. The mean age was 66.1 ± 15.6 yr, and the most common presentation was ... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5570340 Sun, 01 Jan 2012 05:00:00 +0100 5570340 http://www.medworm.com/index.php?rid=5570339&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22219615%26dopt%3DAbstract This study was conducted to evaluate the association of single serum total cholesterol (TC) measurement with cardiovascular diseases (CVD) deaths in Korean adults. The study subjects were taken from the multi-site collaborative dynamic prospective cohort for epidemiologic investigation on cancer risk in residents nearby nuclear power plants in Korea. A total of 12,740 adults aged 40 to 69 yr who underwent a mass screening examination were followed up from 1993 to 2008. Occurring CVD deaths were confirmed by the death certificates in the National Statistical Office, Korea. Groups with the lowest group having TC < 160 mg/dL as well as the highest group having >= 240 mg/dL were associated with higher CVD mortality in Cox proportional hazards analysis adjusting for age, sex, smoking and ... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5570339 Sun, 01 Jan 2012 05:00:00 +0100 5570339 http://www.medworm.com/index.php?rid=5570338&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22219616%26dopt%3DAbstract This study included 105 patients maintaining PD at Seoul National University Hospital. Data were collected from electronic medical record. Korean Beck's Depression Inventory and Korean version of Kidney Disease Quality of Life short form, version 1.3 were used to evaluate depression and HRQOL, respectively. Moderate to severe depression was found in 24.8% of patients. Patients with lower normalized protein equivalent of nitrogen appearance (nPNA) (< 1.2 g/kg/day), lower weekly renal Kt/V(urea) (< 0.2), and lower serum albumin level (≤ 4.0 g/dL) were associated with depression (P < 0.05). Among them, lower weekly renal Kt/V(urea) was the only independent risk factor associated with depression (OR = 3.1, P = 0.007). Depressed patients showed significantly lower scores in every dim... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5570338 Sun, 01 Jan 2012 05:00:00 +0100 5570338 http://www.medworm.com/index.php?rid=5570337&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22219617%26dopt%3DAbstract Authors: Kim EJ, Chung WC, Lee KM, Paik CN, Jung SH, Lee BI, Chae HS, Choi KY Abstract The innate immune response in patients who develop inflammatory bowel disease (IBD) may be abnormal. However, the exact role of Toll-like receptors (TLRs) / CD14 gene in the pathogenesis of IBD has not been fully elucidated. We aimed to investigate the association between polymorphisms of TLR1, 2, 4, 6, and CD14 gene and susceptibility to IBD in Korean population. A total 144 patients of IBD (99 patients with ulcerative colitis, 45 patients with Crohn's disease) and 178 healthy controls were enrolled. Using a PCR-RFLP, we evaluated mutations of TLR1 (Arg80Thr), TLR2 (Arg753Gln and Arg677Trp), TLR4 (Asp299Gly and Thr399Ile), TLR6 (Ser249Pro) genes and the -159 C/T promoter polymorphism of CD14 gen... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5570337 Sun, 01 Jan 2012 05:00:00 +0100 5570337 http://www.medworm.com/index.php?rid=5570336&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22219618%26dopt%3DAbstract Authors: Kwon HJ, Lee JW, Chung NG, Cho B, Kim HK, Kang JH Abstract The aim of this study was to investigate the diphtheria-tetanus-pertussis antibody titers after antineoplastic treatment and to suggest an appropriate vaccination approach for pediatric hemato-oncologic patients. A total of 146 children with either malignancy in remission after cessation of therapy or bone marrow failure were recruited. All children had received routine immunization including diphtheria-tetanus-acellular pertussis vaccination before diagnosis of cancer. The serologic immunity to diphtheria, tetanus and pertussis was classified as: completely protective, partially protective, or non-protective. Non-protective serum antibody titer for diphtheria, tetanus and pertussis was detected in 6.2%, 11.6%, and... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5570336 Sun, 01 Jan 2012 05:00:00 +0100 5570336 http://www.medworm.com/index.php?rid=5570335&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22219619%26dopt%3DAbstract Authors: Chung ME, Lee JI, Im S, Park JH Abstract We hypothesized that the formation and differentialtion of osteoclasts are accelerated and the potential of bone resorption is increased in the hemiplegic bone marrow in the early stage of stroke. We randomly divided white female Sprague-Dawley (SD) rats (n = 30) into two groups, stroke (n = 15) and sham group (n = 15). On the 7th day after stroke, after cutting away the epiphyses of the femurs and tibias, diaphyseal channels were flushed using α-minimum essential medium (α-MEM) and bone marrow cells were collected. Bone marrow stem cells, which were extracted from the femur and tibia, were cultured on the 7th day after middle cerebral artery occlusion. We then estimated the ratio of non-adherent cells to total bone marrow cells t... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5570335 Sun, 01 Jan 2012 05:00:00 +0100 5570335 http://www.medworm.com/index.php?rid=5570334&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22219620%26dopt%3DAbstract We described a 70-yr-old patient who complained of abnormal vaginal bleeding with a collision tumor of the uterine corpus. The patient received total hysterectomy, bilateral salphingo-oophorectomy, bilateral pelvic-paraaortic lymphadenectomy, omentectomy, and intraperitoneal chemotherapy. The uterine corpus revealed three separate masses, which were located at the fundus, anterior and posterior wall. Each tumor revealed three pathologically different components, which were malignant mixed müllerian tumor, papillary serous carcinoma, and endometrioid adenocarcinoma. Among these components, only the papillary serous carcinoma component invaded the underlying myometrium and metastasized to the regional lymph node. Adjuvant chemotherapy and radiation therapy were performed. The patient is sti... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5570334 Sun, 01 Jan 2012 05:00:00 +0100 5570334 http://www.medworm.com/index.php?rid=5570333&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22219621%26dopt%3DAbstract Authors: Jung JW, Lee BO, Lee JH, Park SW, Kim BM, Choi JC, Shin JW, Park IW, Choi BW, Kim JY Abstract A 70-yr-old woman visited our hospital for shortness of breath. Chest CT showed ground glass opacity and traction bronchiectasis at right middle, lower lobe and left lingular division. Video-assisted thoracic surgical biopsy at right lower lobe and pathologic examination revealed mixed dust pneumoconiosis. Polarized optical microscopy showed lung lesions were consisted of silica and carbon materials. She was a housewife and never been exposed to silica dusts occupationally. She has taken freshwater snails as a health-promoting food for 40 yr and ground shell powder was piled up on her backyard where she spent day-time. Energy dispersive X-ray spectroscopy of snail shell and scanni... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5570333 Sun, 01 Jan 2012 05:00:00 +0100 5570333 http://www.medworm.com/index.php?rid=5570332&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22219622%26dopt%3DAbstract We report an unusual case of early-onset childhood sarcoidosis presented with osteolytic bone lesions which were irrelevant to sarcoidosis. PMID: 22219622 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5570332 Sun, 01 Jan 2012 05:00:00 +0100 5570332 http://www.medworm.com/index.php?rid=5570331&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22219623%26dopt%3DAbstract Authors: Karpathios T, Moustaki M, Yiallouros P, Sharifi F, Attilakos A, Papadopoulou A, Fretzayas A Abstract Kawasaki disease is a systemic vasculitis, mainly encountered in children. It may affect any organ. Acute cholestasis and severe obstructive jaundice is an atypical manifestation of the disease. We herein present two children with Kawasaki disease and severe direct hypebilibirunemia who also were homozygous and heterozygous respectively for the (TA)(7) promoter polymorphism of Gilbert syndrome. Intravenous immunoglobulin was administered to both patients at the acute phase of the disease and the fever remitted within 24 hr following the immunoglobulin administration. Furthermore oral aspirin at a dose of 80-100 mg/kg/24 hr was also given. The first child did not develop any... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5570331 Sun, 01 Jan 2012 05:00:00 +0100 5570331 http://www.medworm.com/index.php?rid=5570330&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22219624%26dopt%3DAbstract We report on an angioedema patient with a genetic defect in complement 1 inhibitor, manifesting migraine-like episodes of headache, effective prophylaxis with Danazol, and triptan for a treatment of acute clinical episode. The patient was 44-yr-old Korean man with abdominal pain and headache, who was brought into the Emergency Department of Seoul National University Hospital, Seoul. He suffered from frequent attacks of migraine-like headache (3-7 per month), pulsating in nature associated with nausea. Severities were aggravated by activity and his headache had shown recent progression with abdominal pain. No remarkable findings were observed on radiologic examination, brain magnetic resonance images and intracranial and extracranial magnetic resonance angiography. Danazol 200 mg every othe... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5570330 Sun, 01 Jan 2012 05:00:00 +0100 5570330 http://www.medworm.com/index.php?rid=5570329&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22219625%26dopt%3DAbstract Authors: Ahn JK, Cha HS, Lee J, Jeon CH, Koh EM Abstract Copy number variation has been associated with various autoimmune diseases. We investigated the copy number (CN) of the DEFA1 gene encoding α-defensin-1 in samples from Korean individuals with Behcet's disease (BD) compared to healthy controls (HC). We recruited 55 BD patients and 35 HC. A duplex Taqman® real-time PCR assay was used to assess CN. Most samples (31.1%) had a CN of 5 with a mean CN of 5.4 ± 0.2. There was no significant difference in the CN of the DEFA1 gene between BD patients and HC. A high DEFA1 gene CN was significantly associated with intestinal involvement in BD patients. Variable DEFA1 gene CNs were observed in both BD patients and HC and a high DEFA1 gene CN may be associated with susceptibility to in... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5570329 Sun, 01 Jan 2012 05:00:00 +0100 5570329 http://www.medworm.com/index.php?rid=5519834&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22147988%26dopt%3DAbstract This study was conducted to estimate the socioeconomic costs of overweight and obesity in a sample of Korean adults aged 20 yr and older in 2005. The socioeconomic costs of overweight and obesity include direct costs (inpatient care, outpatient care and medication) and indirect costs (loss of productivity due to premature deaths and inpatient care, time costs, traffic costs and nursing fees). Hypertension, diabetes mellitus, dyslipidemia, ischemic heart disease, stroke, colon cancer and osteoarthritis were selected as obesity-related diseases. The population attributable fraction (PAF) of obesity was calculated from national representative data of Korea such as the National Health Insurance Corporation (NHIC) cohort data and the 2005 Korea National Health and Nutrition Examination Survey (... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5519834 Thu, 01 Dec 2011 05:00:00 +0100 5519834 http://www.medworm.com/index.php?rid=5519833&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22147989%26dopt%3DAbstract Authors: Suh M, Kim HH, Choi DP, Kim KW, Sohn MH, Ha KH, Hwang WJ, Kim C, Kim KE, Shin DC Abstract The purpose of this study was to investigate the association between body mass index (BMI) and the prevalence of wheeze using nation-wide cross-sectional study in Korean children. Total 50,200 children from 427 elementary schools were randomly selected according to residential areas (metropolitan, provincial, rural, and industrial areas) by the cluster sampling method. The International Study of Asthma and Allergies in Childhood (ISAAC) questionnaires were used to measure the prevalence of wheeze. Among 31,026 respondents, 25,322 were analyzed. BMI was classified into quartiles based on BMI-for-age percentile. In all residential areas, pets at home and visible mold or moisture were as... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5519833 Thu, 01 Dec 2011 05:00:00 +0100 5519833 http://www.medworm.com/index.php?rid=5519832&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22147990%26dopt%3DAbstract Authors: Baek HJ, Kook H, Han DK, Hwang TJ Abstract Aim of this study was to compare the outcomes of transplantation by donor source and to help select the best alternative donor in children with leukemia. Donor sources included matched related donor (MRD, n = 35), allele-matched unrelated donor (M-UD, n = 10) or -mismatched (MM)-UD (n = 13) or unrelated umbilical cord blood (UCB, n = 11). UCB group had a significantly higher incidence of grade II-IV acute graft versus host disease (MRD, 11.8%; M-UD, 30.0%; MM-UD, 15.4%, UCB, 54.4%, P = 0.004) but there was no difference in incidence of chronic graft versus host disease between 4 groups. The 5-yr leukemia-free survival (LFS) was 76.7%, 60.0%, 69.2%, and 45.5%, respectively (P = 0.128). MRD group showed higher LFS rate than UCB grou... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5519832 Thu, 01 Dec 2011 05:00:00 +0100 5519832 http://www.medworm.com/index.php?rid=5519831&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22147991%26dopt%3DAbstract Authors: Oh S, Koo DH, Suh C, Kim S, Park BH, Kang J, Huh J Abstract Many predictive models have been proposed for better stratification of diffuse large B-cell lymphoma (DLBCL). Hans' algorithm has been widely used as standard to sub-classify DLBCL into germinal center B-cell (GCB) and non-GCB origins. However, there have been disagreements in the literature regarding its prognostic significance. Here, we retrospectively analyzed Hans' algorithm and the individual immunohistochemical biomarkers at different cut-off values (5%, 30%, 50% or 75%) in 94 Korean patients with DLBCL treated with combination chemotherapy with cyclophosphamide, daunorubicin, vincristine, and prednisone. No significant differences were observed between the GCB (18 patients, 19.1%) and non-GCB (76, 80.9%) gr... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5519831 Thu, 01 Dec 2011 05:00:00 +0100 5519831 http://www.medworm.com/index.php?rid=5519830&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22147992%26dopt%3DAbstract Authors: Kim H, Lim HY Abstract Epidermal growth factor receptor (EGFR)-targeted therapies have been effective in some cancers, but not in hepatocellular carcinoma (HCC). The aim of this study was to investigate the drug potential to overcome multi-drug resistance in HCC cells. Thirteen drug-sensitive HCC cells were assessed using the CCK-8 assay. G(0)-G(1) arrest was measured by FACS. Western blot analysis was used to detect the key enzymes in both the Ras/Raf and PI3K pathways. When establishing the IC(50) of HCC to several drugs, including EKB-569, sorafenib, erlotinib, gefitinib, pazopanib, and brivanib, SK-Hep1 cells treated with EKB-569 have shown the highest (72.8%-86.4%) G(0)-G(1) arrest and decreased the phosphorylation of AKT and ERK at the protein level. We found that EK... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5519830 Thu, 01 Dec 2011 05:00:00 +0100 5519830 http://www.medworm.com/index.php?rid=5519829&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22147993%26dopt%3DAbstract Authors: Jeong J, Lee KS, Choi YK, Oh YJ, Lee HD Abstract Bisphosphonates are used routinely to reduce bone-related events in breast cancer patients with bone metastasis. We evaluated the effects of zoledronic acid, a third generation, nitrogen-containing bisphosphonate, to prevent bone metastasis in breast cancer. Zoledronic acid or vehicle alone was administered to nude mice either simultaneously or after intracardiac injection of human breast cancer MDA-MB-231 cells. Nude mice treated with zoledronic acid at early time points showed a lower incidence of bone metastases than did vehicle-treated nude mice, but these differences were not statistically significant. Only 37.5% of mice treated with zoledronic acid at the time of tumor cell inoculation developed bone metastases compare... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5519829 Thu, 01 Dec 2011 05:00:00 +0100 5519829 http://www.medworm.com/index.php?rid=5519828&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22147994%26dopt%3DAbstract Authors: Jung BC, Lee SH, Cho YK, Park HS, Kim YN, Lee YS, Shin DG Abstract Under conditions of Na(+) channel hyperactivation with aconitine, the changes in action potential duration (APD) and the restitution characteristics have not been well defined in the context of aconitine-induced arrhythmogenesis. Optical mapping of voltage using RH237 was performed with eight extracted rabbit hearts that were perfused using the Langendorff system. The characteristics of APD restitution were assessed using the steady-state pacing protocol at baseline and 0.1 µM aconitine concentration. In addition, pseudo-ECG was analyzed at baseline, and with 0.1 and 1.0 µM of aconitine infusion respectively. Triggered activity was not shown in dose of 0.1 µM aconitine but overtly presented in 1.0 µM of... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5519828 Thu, 01 Dec 2011 05:00:00 +0100 5519828 http://www.medworm.com/index.php?rid=5519827&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22147995%26dopt%3DAbstract Authors: Jeong DS, Lee HY, Kim WS, Sung K, Jun TG, Yang JH, Park PW, Lee YT Abstract Management of ischemic mitral regurgitation (MR) is challenging. The aim of this study was to investigate long-term clinical and echocardiographic results of restrictive mitral annuloplasty for ischemic MR. From 2001 through 2010, 96 patients who underwent myocardial revascularization with restrictive mitral annuloplasty using a vascular strip for ischemic MR were analyzed. Patients were stratified into two groups based on left ventricular ejection fraction (LVEF): group I, n = 50, with LVEF > 35% and group II, n = 46, with LVEF ≤ 35%. The early mortality rate was 2.1% (2/96) and the late cardiac mortality rate was 11.5% (11/96). MR grade was reduced at discharge (0.8 ± 0.7) but increased dur... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5519827 Thu, 01 Dec 2011 05:00:00 +0100 5519827 http://www.medworm.com/index.php?rid=5519826&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22147996%26dopt%3DAbstract Authors: Lim KM, Lee JS, Song JH, Youn CH, Choi JS, Shim EB Abstract Left ventricular assist device (LVAD) support under cannulation connected from the left atrium to the aorta (LA-AA) is used as a bridge to recovery in heart failure patients because it is non-invasive to ventricular muscle. However, it has serious problems, such as valve stenosis and blood thrombosis due to the low ejection fraction of the ventricle. We theoretically estimated the effect of the in-series cannulation, connected from ascending aorta to descending aorta (AA-DA), on ventricular unloading as an alternative to the LA-AA method. We developed a theoretical model of a LVAD-implanted cardiovascular system that included coronary circulation. Using this model, we compared hemodynamic responses according to va... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5519826 Thu, 01 Dec 2011 05:00:00 +0100 5519826 http://www.medworm.com/index.php?rid=5519825&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22147997%26dopt%3DAbstract Authors: Hong S, Oh HJ, Choi H, Kim JG, Lim SK, Kim EK, Pyo EY, Oh K, Kim YT, Wilson K, Choi WH Abstract Accurate measurement of fat mass has become increasingly important with the increasing incidence of obesity. We assessed fat and muscle mass of Koreans with the Korea National Health and Nutrition Examination Survey IV (KNHANES IV). We studied 10,456 subjects (aged 20 to 85 yr; 4,476 men, 5,980 women). Fat and muscle mass were measured by dual-energy x-ray absorptiometry. Reference values of body compositions were obtained using the LMS method. The fat mass index (FMI, body fat mass/height(2); kg/m(2)) of Korean men did not correlate with age (P = 0.452), but those of Korean women (P < 0.001) did. The ratio of percentage of fat in the trunk and legs was positively related wit... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5519825 Thu, 01 Dec 2011 05:00:00 +0100 5519825 http://www.medworm.com/index.php?rid=5519824&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22147998%26dopt%3DAbstract Authors: Yoo JW, Hong Y, Seo JB, Chae EJ, Ra SW, Lee JH, Kim EK, Baek S, Kim TH, Kim WJ, Lee JH, Lee SM, Lee S, Lim SY, Shin TR, Yoon HI, Sheen SS, Lee JS, Huh JW, Oh YM, Lee SD Abstract To date, clinico-physiologic indices have not been compared with quantitative CT imaging indices in determining the risk of chronic obstructive pulmonary disease (COPD) exacerbation. We therefore compared clinico-physiologic and CT imaging indices as risk factors for COPD exacerbation in patients with COPD. We retrospectively analyzed 260 COPD patients from pulmonary clinics at 11 hospitals in Korea from June 2005 to November 2009 and followed-up for at least one year. At the time of enrollment, none of these patients had COPD exacerbations for at least 2 months. All underwent clinico-physiologic a... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5519824 Thu, 01 Dec 2011 05:00:00 +0100 5519824 http://www.medworm.com/index.php?rid=5519823&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22147999%26dopt%3DAbstract In conclusion, a full-dose PPI is preferred for the initial and maintenance treatment of GERD under the minimal influence of the insurance reimbursement guideline, which may reflect a high proportion of GERD patients requiring a long-term treatment of a full-dose PPI. PMID: 22147999 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5519823 Thu, 01 Dec 2011 05:00:00 +0100 5519823 http://www.medworm.com/index.php?rid=5519822&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22148000%26dopt%3DAbstract Authors: Kwon JY, Park IY, Park YG, Lee Y, Lee G, Shin JC Abstract The purpose of the current study was to propose a Korean-specific parameter set for calculating the risk of Down syndrome in the second trimester of pregnancy and to determine the screening performances of triple and quadruple tests in Korean women. Using the data on triple or quadruple screening from three hospitals in Korea during 7 yr, we re-converted the concentrations of four serum markers to multiple of median values according to gestational age and maternal weight. After re-calculating the risk of Down syndrome in each pregnancy by multiplying maternal age-specific risk by the likelihood ratio values for the serum markers, screening performances and optimal cut-off values of triple and quadruple tests were an... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5519822 Thu, 01 Dec 2011 05:00:00 +0100 5519822 http://www.medworm.com/index.php?rid=5519821&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22148001%26dopt%3DAbstract Authors: Ji HM, Lee YK, Ha YC, Kim KC, Koo KH Abstract Since the late 1980s, low dose aspirin has been used to prevent stroke and ischemic heart disease. However, prophylactic effect of antiplatelets against venous thromboembolism (VTE), in patients who undergo hip fracture surgery (HFS) is controversial. Our purpose was to determine the incidence of symptomatic VTE after HFS and to evaluate whether antiplatelets reduce the development of symptomatic VTE following HFS. We retrospectively reviewed 858 HFS in 824 consecutive patients which were performed from May 2003 to April 2010 at an East Asian institute. We compared the incidence of symptomatic VTE in antiplatelet users and non-users using multivariate logistic regression analyses. Overall incidences of symptomatic pulmonary emb... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5519821 Thu, 01 Dec 2011 05:00:00 +0100 5519821 http://www.medworm.com/index.php?rid=5519820&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22148002%26dopt%3DAbstract We describe an outbreak of 12 cases of trichinellosis in Korea and implicate raw wild boar meat as the culprit. A total of 27 larvae of Trichinella (0.54 larvae per gram of meat) were recovered from the leftover raw wild boar meat. PMID: 22148002 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5519820 Thu, 01 Dec 2011 05:00:00 +0100 5519820 http://www.medworm.com/index.php?rid=5519819&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22148003%26dopt%3DAbstract In conclusion, fluvastatin should be used with caution in patients with liver cirrhosis, especially with other medications metabolized with CYP2C9. PMID: 22148003 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5519819 Thu, 01 Dec 2011 05:00:00 +0100 5519819 http://www.medworm.com/index.php?rid=5519818&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22148004%26dopt%3DAbstract Authors: Kim BK, Choi YS, Park YH, Lee SU Abstract Interferon-induced thyroiditis (IIT) is a major clinical problem for patients receiving interferon-alpha (IFN-α) therapy. But, destructive thyroiditis followed by Graves' disease associated with IFN-α therapy is very rarely reported. Herein, we report a rare case of pegylated IFN-α (pegIFN-α) induced destructive thyroiditis followed by Graves' disease in a patient with HCV infection. A 31-yr-old woman suffered from chronic active hepatitis C and was treated with pegIFN-α and ribavirin for 12 months. Results of a thyroid function test and autoantibody levels were normal before IFN-α therapy was initiated. Destructive thyrotoxicosis appeared seven months after the initiation of IFN-α therapy, followed by Graves' thyrotoxicosis... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5519818 Thu, 01 Dec 2011 05:00:00 +0100 5519818 http://www.medworm.com/index.php?rid=5519817&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22148005%26dopt%3DAbstract Authors: Kim HK, Lee JY, Bae EJ, Oh PS, Park WI, Lee DS, Kim JI, Lee HJ Abstract Hutchinson-Gilford progeria syndrome (HGPS) is a rare condition originally described by Hutchinson in 1886. Death result from cardiac complications in the majority of cases and usually occurs at average age of thirteen years. A 4-yr old boy had typical clinical findings such as short stature, craniofacial disproportion, alopecia, prominent scalp veins and sclerodermatous skin. This abnormal appearance began at age of 1 yr. On serological and hormonal evaluation, all values are within normal range. He was neurologically intact with motor and mental development. An echocardiogram showed calcification of aortic and mitral valves. Hypertrophy of internal layer at internal carotid artery suggesting atherosc... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5519817 Thu, 01 Dec 2011 05:00:00 +0100 5519817 http://www.medworm.com/index.php?rid=5519816&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22148006%26dopt%3DAbstract Authors: Shim YJ, Kim HJ, Suh JS, Lee KS Abstract Severe congenital neutropenia is a heterozygous group of bone marrow failure syndromes that cause lifelong infections. Mutation of the ELANE gene encoding human neutrophil elastase is the most common genetic alteration. A Korean female pediatric patient was admitted because of recurrent cervical lymphadenitis without abscess formation. She had a past history of omphalitis and isolated neutropenia at birth. The peripheral blood showed a markedly decreased absolute neutrophil count, and the bone marrow findings revealed maturation arrest of myeloid precursors at the promyelocyte to myelocyte stage. Her direct DNA sequencing analysis demonstrated an ELANE gene mutation (c.607G > C; p.Gly203Arg), but her parents were negative for it.... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5519816 Thu, 01 Dec 2011 05:00:00 +0100 5519816 http://www.medworm.com/index.php?rid=5429686&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22065894%26dopt%3DAbstract Authors: Lee WJ, Choi BS, Kim SJ, Park CK, Park JS, Tae S, Hering KG Abstract We developed the standard digital images (SDIs) to be used in the classification and recognition of pneumoconiosis. From July 3, 2006 through August 31, 2007, 531 retired male workers exposed to inorganic dust were examined by digital (DR) and analog radiography (AR) on the same day, after being approved by our institutional review board and obtaining informed consent from all participants. All images were twice classified according to the International Labour Office (ILO) 2000 guidelines with reference to ILO standard analog radiographs (SARs) by four chest radiologists. After consensus reading on 349 digital images matched with the first selected analog images, 120 digital images were selected as the SD... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5429686 Tue, 01 Nov 2011 04:00:00 +0100 5429686 http://www.medworm.com/index.php?rid=5429685&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22065895%26dopt%3DAbstract Authors: Rim H, Kim H, Lee K, Chang S, Hovell MF, Kim YT, Kim Y, Kang G, Tak Y, Im J Abstract To evaluate the sensitivity and specificity of Community Health Survey (CHS), we analyzed data from 11,217 participants aged ≥ 19 yr, in 13 cities and counties in 2008. Three healthcare utilization indices (admission, outpatient visits, dental visits) as comparative variables and the insurance benefit claim data of the Health Insurance Review & Assessment Service as the gold-standard were used. The sensitivities of admission, outpatient visits, and dental visits in CHS were 54.8%, 52.1%, and 61.0%, respectively. The specificities were 96.4%, 85.6%, and 82.7%, respectively. This is the first study to evaluate the validity of nationwide health statistics resulting from questionnaire su... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5429685 Tue, 01 Nov 2011 04:00:00 +0100 5429685 http://www.medworm.com/index.php?rid=5429684&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22065896%26dopt%3DAbstract In conclusion, the clinical presentation of A. caviae bacteremia was much different from A. hydrophila and A. veronii biovar sobria bacteremia. The severity and mortality of A. caviae bacteremia were lower than A. hydrophila or A. veronii biovar sobria bacteremia. PMID: 22065896 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5429684 Tue, 01 Nov 2011 04:00:00 +0100 5429684 http://www.medworm.com/index.php?rid=5429683&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22065897%26dopt%3DAbstract We report results of a randomized, double-blinded, active-controlled, phase III study conducted to evaluate the immunogenicity and safety of a new trivalent inactivated split-virus influenza vaccine (GC501) manufactured by the Green Cross Corporation in Korea. A total of 283 healthy children aged 6 months to < 18 yr were randomized to receive either GC501 or control. Of the GC501 recipients, seroconversion occurred in 48.5% for A/H1N1, 67.7% for A/H3N2 and 52% for influenza B. The proportion of subjects who had post-vaccination hemagglutination-inhibition titers of 1:40 or greater was 90.7% for A/H1N1, 86.8% for A/H3N2 and 82.4% for influenza B in the GC501 recipients. No serious adverse events related to vaccination, or withdrawals because of adverse events were reported. The majority ... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5429683 Tue, 01 Nov 2011 04:00:00 +0100 5429683 http://www.medworm.com/index.php?rid=5429682&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22065898%26dopt%3DAbstract In conclusion, potential tumor suppressor (CFH, MYRIP) and oncogenes (PSRC1, MRE11A, MYO1E) in HCC are reported. The regulation of individual genes by methylation in hepatocarcinogenesis needs to be validated. PMID: 22065898 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5429682 Tue, 01 Nov 2011 04:00:00 +0100 5429682 http://www.medworm.com/index.php?rid=5429681&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22065899%26dopt%3DAbstract Authors: Hwang JE, Shim HJ, Park YK, Cho SH, Bae WK, Kim DE, Kim KK, Chung IJ Abstract KITENIN (KAI1 C-terminal interacting tetraspanin) promotes invasion and metastasis in mouse colon cancer models. In the present study, we evaluated the effects of KITENIN knockdown by intravenous administration of short hairpin RNAs (shRNAs) in an orthotopic mouse colon cancer model, simulating a primary or adjuvant treatment setting. We established orthotopic models for colon cancer using BALB/c mice and firefly luciferase-expressing CT-26 (CT26/Fluc) cells. Tumor progression and response to therapy were monitored by bioluminescence imaging (BLI). In the primary therapy model, treatment with KITENIN shRNA substantially delayed tumor growth (P = 0.028) and reduced the incidence of hepatic metasta... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5429681 Tue, 01 Nov 2011 04:00:00 +0100 5429681 http://www.medworm.com/index.php?rid=5429680&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22065900%26dopt%3DAbstract Authors: Chon SB, Oh WS, Cho JH, Kim SS, Lee SJ Abstract Cardiothoracic ratio (CTR), the ratio of cardiac diameter (CD) to thoracic diameter (TD), is a useful screening method to detect cardiomegaly, but is reliable only on posteroanterior chest radiography (chest PA). We performed this cross-sectional 3-phase study to establish reliable CTR from anteroposterior chest radiography (chest AP). First, CD(Chest PA)/CD(Chest AP) ratios were determined at different radiation distances by manipulating chest computed tomography to simulate chest PA and AP. CD(Chest PA) was inferred from multiplying CD(Chest AP) by this ratio. Incorporating this CD and substituting the most recent TD(Chest PA), we calculated the 'corrected' CTR and compared it with the conventional one in patients who took ... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5429680 Tue, 01 Nov 2011 04:00:00 +0100 5429680 http://www.medworm.com/index.php?rid=5429679&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22065901%26dopt%3DAbstract Authors: Kang MJ, Kim SM, Lee YA, Shin CH, Yang SW Abstract A single measurement of serum 17α-hydroxyprogesterone (17OHP) level can be unreliable because of its marked diurnal variation. We investigated the relationship of serum level of 17OHP with that of androstenedione (AD), which shows a smaller diurnal variation. And we tested whether the responses of these two hormones to low-dose ACTH stimulation are correlated in patients with 21-hydroxylase deficiency. Baseline serum 17OHP and AD levels were measured in 87 patients and a low-dose ACTH stimulation test was performed in 41 patients. The basal 17OHP level correlated positively with the basal AD level independently of sex, type of 21-hydroxylase deficiency, and the time of day of blood sampling (n = 87, R(2) = 0.75, P < 0.... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5429679 Tue, 01 Nov 2011 04:00:00 +0100 5429679 http://www.medworm.com/index.php?rid=5429678&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22065902%26dopt%3DAbstract This study was performed to describe the patterns of healthcare switching with overlapping use of anti-diabetic medication in the elderly using the Korea Health Insurance Review and Assessment Service's claims data. The study subjects were ambulatory elderly diabetic patients (ICD-10, E10-14) receiving at least one oral anti-diabetic drug or insulin, and visiting healthcare facilities more than two times between January and December 2005. A total of 457,975 elderly diabetic ambulatory care patients were identified. The mean of visiting frequencies was 9.0 ( ± 3.6) and switching frequencies was 1.5 ( ± 0.8) during 2005. Switching group consisted of 33% of total study subject. Healthcare switching was common in female patients who were older, and had treated polytherapy more in rural areas... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5429678 Tue, 01 Nov 2011 04:00:00 +0100 5429678 http://www.medworm.com/index.php?rid=5429677&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22065903%26dopt%3DAbstract Authors: Feng K, Chen L, Han SM, Zhu GJ Abstract In China there are 1,923,842 Korean Chinese, who live mostly (92.27%) in the country's three northeast provinces. In spite of this sizeable number, no spirometric data are available at present on them. The present study investigated normal spirometric reference values for the Korean Chinese children and adolescents. Spirometry was performed in 443 healthy Korean Chinese children and adolescents aged 8-18 yr with measurements of forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), peak expiratory flow (PEF) and maximum mid-expiratory flow (MMEF). Reference equations for FEV1, FVC, PEF and MMEF were derived by using multiple regression analysis. All of the measured spirometric parameters correlated positively with ... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5429677 Tue, 01 Nov 2011 04:00:00 +0100 5429677 http://www.medworm.com/index.php?rid=5429676&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22065904%26dopt%3DAbstract In this study, we investigated Nrf2 induction in response to SFN in human bronchial epithelial BEAS-2B cells and determined the signaling pathways involved in this process. SFN treatment reduced cell viability. Prior to cell death, intracellular reactive oxygen species (ROS) were generated at a high rate within a minute of commencing SFN treatment. Pretreatment with antioxidant N-acetylcysteine (NAC) blocked SFN-induced decrease in cell growth. Erk1/2 was activated within 30 min of SFN addition, whereas Akt phosphorylation did not significantly change until the first 8 hr after SFN treatment but then became substantially low until 48 hr. Inhibition of Erk1/2 phosphorylation attenuated SFN-induced loss of cell viability. Nrf2 protein levels in both nuclear and whole cell lysates were increa... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5429676 Tue, 01 Nov 2011 04:00:00 +0100 5429676 http://www.medworm.com/index.php?rid=5429675&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22065905%26dopt%3DAbstract This study can contribute to the further prospective study with a larger scale, suggesting the assumption that KIR2DS2 might aid in HCV clearance by enhancing both the innate and acquired immune responses of people in Korea. PMID: 22065905 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5429675 Tue, 01 Nov 2011 04:00:00 +0100 5429675 http://www.medworm.com/index.php?rid=5429674&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22065906%26dopt%3DAbstract In conclusion, flavonoids treatment induces up-regulation of p21 expression, and p21 inhibits transcription of PLK-1, which promotes apoptosis of cancer cells. PMID: 22065906 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5429674 Tue, 01 Nov 2011 04:00:00 +0100 5429674 http://www.medworm.com/index.php?rid=5429673&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22065907%26dopt%3DAbstract This study was conducted to evaluate the protective effect of hypoxic preconditioning on hypoxic-ischemic injury in the neonatal rat and the persistence of a protective window after hypoxic preconditioning. The rats were preconditioned with hypoxia (8% oxygen, 92% nitrogen) for three hours, subjected to ischemia using ligation of the right common carotid artery, and then exposed to another three hours of hypoxia. Using proton magnetic resonance spectroscopy, terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling (TUNEL) staining, and morphologic scores, this study shows that hypoxic preconditioning 6-hr to 1-day before hypoxic-ischemic injury increases survival rates and has neuroprotective effects against subsequent hypoxic-ischemic injury. The mechanism of the prote... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5429673 Tue, 01 Nov 2011 04:00:00 +0100 5429673 http://www.medworm.com/index.php?rid=5429672&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22065908%26dopt%3DAbstract This study was to determine the orthopedic surgeons' awareness could increase the osteoporosis treatment rate after a hip fracture and the patient barriers to osteoporosis management. We prospectively followed 208 patients older than 50 yr who were enrolled for hip fractures during 2007 in Jeju-cohort. Thirty four fractures in men and 174 in women were treated at the eight hospitals. During the study period, orthopedic surgeons who worked at these hospitals attended two education sessions and were provided with posters and brochures. Patients were interviewed 6 months after discharge using an evaluation questionnaire regarding their perceptions of barriers to osteoporosis treatment. The patients were followed for a minimum of one year. Ninety-four patients (45.2%) underwent detection of os... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5429672 Tue, 01 Nov 2011 04:00:00 +0100 5429672 http://www.medworm.com/index.php?rid=5429671&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22065909%26dopt%3DAbstract We report the first case of PAMT in Korea. A 52-yr-old man underwent esophagogastroduodenoscopy due to dyspepsia for 2 yr. There was a submucosal mass with small mucosal ulceration in the gastric antrum. The tumor measured 3.5 × 2.3 cm in size and showed multinodular plexiform growth pattern of bland-looking spindle cells separated by an abundant myxoid or fibromyxoid matrix rich in small thin-walled blood vessels. The tumor cells were negative for CD117 (c-KIT), CD34 and S-100 protein, but diffusely positive for smooth muscle actin consistent with predominant myofibroblastic differentiation. The patient is doing well without recurrence or metastasis for 5 months after surgery. Although there have been limited follow-up data, PAMT is regarded as a benign gastric neoplasm with histological... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5429671 Tue, 01 Nov 2011 04:00:00 +0100 5429671 http://www.medworm.com/index.php?rid=5429670&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22065910%26dopt%3DAbstract Authors: Ahn J, Park SH, Shin WY, Lee SW, Lee SJ, Jin DK, Kim D, Kim TH Abstract Atherosclerotic renal artery stenosis (RAS) usually involves the ostium and the proximal one-third of the renal artery main branch. Percutaneous renal artery angioplasty with stent placement is a well recognized treatment for atherosclerotic RAS. Occasionally, atherosclerotic RAS involves renal artery bifurcations. However, stent implantation in atherosclerotic RAS involving bifurcation is not only troublesome, but also challenging because of side branch occlusion and in-stent restenosis (ISR). In the present report, we describe the use of drug-eluting stents (DES) with provisional T-stenting technique for the treatment of renal artery bifurcation lesion. Follow-up angiogram showed no significant ISR 1... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5429670 Tue, 01 Nov 2011 04:00:00 +0100 5429670 http://www.medworm.com/index.php?rid=5429669&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22065911%26dopt%3DAbstract We report the first case of dCJD in Korea. A 54-yr-old woman, who underwent resection of the meningioma in the left frontal region and received a dura mater graft 23 yr ago presented with dysesthesia followed by psychiatric symptoms and ataxia. Her neurological symptoms rapidly progressed to such an extent that she exhibited myoclonus, dementia, and pyramidal and extrapyramidal signs within 8 weeks. The 14-3-3 protein was detected in her cerebrospinal fluid; however, an electroencephalogram did not reveal characteristic positive sharp wave complexes. Diffusion-weighted magnetic resonance images, obtained serially over 64 days, revealed the rapid progression of areas of high signal intensity in the caudate nucleus and cingulate gyrus to widespread areas of high signal intensity in the corte... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5429669 Tue, 01 Nov 2011 04:00:00 +0100 5429669 http://www.medworm.com/index.php?rid=5429668&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22065912%26dopt%3DAbstract We report the first case of Susac syndrome in Koreans, in a 23-yr-old female patient who presented with sudden visual loss and associated neurological symptoms. Ophthalmic examination and fluorescein angiography showed multiple areas of branch retinal artery occlusion, which tended to recur in both eyes. Magnetic resonance imaging showed dot-like, diffusion-restricted lesions in the corpus callosum and left fornix, and audiometry showed low-frequency sensory hearing loss, compatible with Susac syndrome. She received immunosuppressive therapy with oral steroid and azathioprine. Three months later all the symptoms disappeared but obstructive vasculitis have been relapsing. This patient demonstrated the entire clinical triad of Susac syndrome, which tends to occur in young females. Although t... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5429668 Tue, 01 Nov 2011 04:00:00 +0100 5429668 http://www.medworm.com/index.php?rid=5429667&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22065913%26dopt%3DAbstract We report a case of early non-invasive diagnosis of acute eosinophilic myopericarditis (AEM) by cardiovascular magnetic resonance (CMR) before cardiac biopsy. A 35-yr-old woman presented with a flu-like illness, followed by pleuritic chest pain and shortness of breath. Transthoracic echocardiography revealed mild left ventricular (LV) systolic dysfunction with borderline LV wall thickness and moderate pericardial effusion. The patient had peripheral eosinophilia and CMR was performed immediately at first day of visit before cardiac biopsy. CMR showed diffuse subepicardial high T2 signals and diffuse late gadolinium enhancement in LV. Steroid therapy was immediately initiated and patient's symptom was rapidly improved. Endomyocardial biopsy at hospital day 3 reported multifocal mild infiltr... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5429667 Tue, 01 Nov 2011 04:00:00 +0100 5429667 http://www.medworm.com/index.php?rid=5429666&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22065914%26dopt%3DAbstract Authors: Bae EY, Lee EJ, Kang HG, Lee SY, Jin G, Lee WK, Choi JE, Jeon HS, Lim JO, Lee EB, Park JY Abstract Apoptosis plays an essential role in the elimination of mutated or transformed cells from the body. Therefore, polymorphisms of apoptosis-related genes may lead to an alteration in apoptotic capacity, thereby affecting the occurrence of TP53 mutations in lung cancer. We investigated the relationship between potentially functional polymorphisms of apoptosis-related genes and TP53 mutations in non-small cell lung cancer (NSCLC). Twenty-seven single nucleotide polymorphisms in 20 apoptosis-related genes were genotyped by a sequenome mass spectrometry-based genotyping assay in 173 NSCLCs and the associations with TP53 mutations in the entire coding exons (exons 2-11), including s... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5429666 Tue, 01 Nov 2011 04:00:00 +0100 5429666 http://www.medworm.com/index.php?rid=5429665&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22065915%26dopt%3DAbstract Authors: Abstract [This corrects the article on p. 1147 in vol. 26, PMID: 21935268.]. PMID: 22065915 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5429665 Tue, 01 Nov 2011 04:00:00 +0100 5429665 http://www.medworm.com/index.php?rid=5350829&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22022174%26dopt%3DAbstract In conclusion, the concentrations of calcium, magnesium, iron, and manganese in the hair of female patients with fibromyalgia are lower than of controls, even after adjustment of potential confounders. PMID: 22022174 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5350829 Sat, 01 Oct 2011 04:00:00 +0100 5350829 http://www.medworm.com/index.php?rid=5350811&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22022175%26dopt%3DAbstract In conclusion, the incidence of CDI in Korea is a little higher than other reports during the non-epidemic setting. We expect that the change of epidemiology and clinical severity in CDI can be evaluated based on these results. PMID: 22022175 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5350811 Sat, 01 Oct 2011 04:00:00 +0100 5350811 http://www.medworm.com/index.php?rid=5350783&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22022176%26dopt%3DAbstract This study reveals that eNO level is associated with allergic inflammation and the degree of allergic sensitization. PMID: 22022176 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5350783 Sat, 01 Oct 2011 04:00:00 +0100 5350783 http://www.medworm.com/index.php?rid=5350782&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22022177%26dopt%3DAbstract Authors: Oh SM, Oh K, Lee DS Abstract Secondary lymphoid tissue chemokine (SLC), which is expressed in T cell zones of secondary lymphoid organs, including the spleen and lymph nodes, strongly recruits both T lymphocytes and mature dendritic cells. As appropriate interaction of tumor-specific T cells and mature dendritic cells, equipped with tumor antigens, is a prerequisite for effective T cell immunity against established tumors, we mobilized lymphocytes and dendritic cells to tumor sites by intratumoral injection of secondary lymphoid tissue chemokine-Fc (SLC-Fc) fusion protein using the B16F10 murine melanoma model. Activation of dendritic cells, another prerequisite for the effective activation of naïve tumor-specific T cells, was achieved by the addition of immunostimulatory... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5350782 Sat, 01 Oct 2011 04:00:00 +0100 5350782 http://www.medworm.com/index.php?rid=5350781&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22022178%26dopt%3DAbstract Authors: Kim JW, Kwon GY, Roh JL, Choi SH, Nam SY, Kim SY, Cho KJ Abstract In carcinoma ex pleomorphic adenoma (CXPA), pleomorphic adenoma (PA) and diverse carcinoma components showing luminal (ductal) or non-luminal (myoepithelial) differentiation coexist. To elucidate the clinicopathological implications of cellular differentiation in CXPA and the potential role of p53, vascular endothelial growth factor (VEGF), c-erbB-2, c-kit, and glucose transporter 1 (Glut-1) in carcinogenesis, we analyzed 11 CXPAs with luminal differentiation (CXPAs-LD) and 6 CXPAs with non-luminal differentiation (CXPAs-NLD) and compared protein expressions in residual PAs and carcinomas by immunohistochemistry. Among the CXPAs-LD, 5 were invasive and 8 were histologically high-grade tumors. The 5-year surv... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5350781 Sat, 01 Oct 2011 04:00:00 +0100 5350781 http://www.medworm.com/index.php?rid=5350748&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22022179%26dopt%3DAbstract Authors: Lee JH, Yang DH, Park HS, Cho Y, Jun JE, Park WH, Chun BY, Shin JY, Shin DH, Lee KS, Kim KS, Kim KB, Kim YJ, Chae SC, Abstract Limited data are available about the incidence of hypertension over the 5-yr in non-hypertensive subjects. The study subjects were 1,806 subjects enrolled in a rural area of Daegu, Korea for a cohort study from August to November 2003. Of them, 1,287 (71.3%) individuals had another examination 5 yr later. To estimate the incidence of hypertension, 730 non-hypertensive individuals (265 males; mean age = 56.6 ± 11.1 yr-old) at baseline examination were analyzed in this study. Hypertension was defined as either a new diagnosis of hypertension or self-reports of newly initiated antihypertensive treatment; prehypertension was if the systolic blood pre... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5350748 Sat, 01 Oct 2011 04:00:00 +0100 5350748 http://www.medworm.com/index.php?rid=5350741&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22022180%26dopt%3DAbstract This study examined the normal ranges and the determinants for various parameters of the short-term heart rate variability (HRV) measurements in a large Korean sample of healthy people. HRV measurements were obtained in 2,748 healthy men and 735 healthy women 18-65 yr of age. The mean total power (TP), low frequency (LF), high frequency (HF), and LF/HF ratio were 1,358.9 ± 1,840.8 ms(2), 417.3 ± 807.6 ms(2), 254.1 ± 414.1 ms(2), and 2.4 ± 20.9 ms(2) in the frequency-domain spectral analysis. The mean standard deviation of the normal-to-normal (NN) interval (SDNN) and the square root of the mean squared differences of successive NN intervals (RMSSD) were 39.6 ± 22.1 ms and 29.7 ± 18.1 ms in the time-domain analysis. The female subjects had significantly higher SDNN, RMSSD, and HF valu... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5350741 Sat, 01 Oct 2011 04:00:00 +0100 5350741 http://www.medworm.com/index.php?rid=5350740&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22022181%26dopt%3DAbstract In conclusion, long-term DES use in diffuse long coronary lesions is associated with favorable results, with SES being more effective and safer than PES in this real-world clinical experience. PMID: 22022181 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5350740 Sat, 01 Oct 2011 04:00:00 +0100 5350740 http://www.medworm.com/index.php?rid=5350739&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22022182%26dopt%3DAbstract This study examined the association between serum GGT concentration and Framingham risk score (FRS) in the Korean population. This cross-sectional study was performed on 30,710 Koreans. Besides FRS, body mass index, fasting blood glucose, liver enzymes, lipid profile, uric acid and high sensitive C-reactive protein data were used. The study subjects were grouped into quartiles according to the levels of GGT. Analyses relating GGT to FRS ≥ 20% utilized multiple confounders adjusted logistic regression. Positive correlations were established between log-transformed GGT concentration and FRS (r = 0.38; P < 0.001). Increasing the quartile of serum GGT concentration was significantly associated with linear increasing trends in FRS (P-trend < 0.001). Compared to the lowest baseline GGT c... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5350739 Sat, 01 Oct 2011 04:00:00 +0100 5350739 http://www.medworm.com/index.php?rid=5350738&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22022183%26dopt%3DAbstract This study was done to observe the alteration of the estimated glomerular filtration rate (eGFR) in multiple myeloma patients according to type of tandem hematopoietic stem cell transplantation (HSCT). Forty-one patients were enrolled in this study. Twenty patients underwent autologous HSCT (auto-HSCT) and 21 patients underwent allogeneic HSCT (allo-HSCT). The changes in eGFR after the two tandem HSCT modalities were different between the two groups, according to the donor of stem cells (P = 0.016). In the auto-HSCT group, the eGFR, recorded 12 months after secondary HSCT, was significantly decreased compared with the eGFR recorded before stem cell mobilization (P = 0.005). Although there was no significant difference, the trend showed that the eGFR after allo-HSCT decreased from the previ... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5350738 Sat, 01 Oct 2011 04:00:00 +0100 5350738 http://www.medworm.com/index.php?rid=5350737&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22022184%26dopt%3DAbstract Authors: Ha TS, Choi JY, Park HY, Lee JS Abstract Early diabetic nephropathy is characterized by glomerular hyperpermeability as a result of impaired glomerular filtration structure caused by hyperglycemia, glycated proteins or irreversible advanced glycosylation endproducts (AGE). To investigate the effect of ginseng total saponin (GTS) on the pathologic changes of podocyte ZO (zonula occludens)-1 protein and podocyte permeability induced by diabetic conditions, we cultured mouse podocytes under: 1) normal glucose (5 mM, = control); 2) high glucose (HG, 30 mM); 3) AGE-added; or 4) HG plus AGE-added conditions and treated with GTS. HG and AGE increased the dextran filtration of monolayered podocytes at early stage (2-8 hr) in permeability assay. In confocal imaging, ZO-1 colocalize... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5350737 Sat, 01 Oct 2011 04:00:00 +0100 5350737 http://www.medworm.com/index.php?rid=5350736&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22022185%26dopt%3DAbstract Authors: Lee S, Kim IT, Park HB, Hyun YK, Kim YJ, Song SO, Kim H Abstract Inflammation is thought to play a role in the pathogenesis of major adverse cardiovascular events (MACE). It has been suggested that the measurement of markers of inflammation may aid in predicting the risk of such events. Here, the relationship between high-sensitivity C-reactive protein (hs-CRP) levels and MACE in Korean patients with type 2 diabetes is assessed. A retrospective cohort study was conducted as a follow-up among 1,558 patients with type 2 diabetes and without cardiovascular diseases over a mean period of 55.5 months. A Cox proportional-hazards model was used to determine whether increased hs-CRP levels are useful as a predictor for future MACE. The hazard ratio of MACE was 1.77 (95% CI; 1.16-2... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5350736 Sat, 01 Oct 2011 04:00:00 +0100 5350736 http://www.medworm.com/index.php?rid=5350735&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22022186%26dopt%3DAbstract Authors: Joo NS, Kim KN, Kim KS Abstract Serum carbohydrate antigen 125 (CA-125) is a marker of ovarian cancer and obesity that is related with an increased risk of ovarian cancer. Obesity is a key factor of metabolic syndrome. We evaluated the relationship between CA-125 concentration and metabolic syndrome. The data from subjects who had any cancer and chronic infection were excluded. The data of 12,196 healthy Korean women were analyzed. After CA-125 concentration was divided by quartiles, the prevalence of metabolic syndrome and its components were compared. The lowest quartile of CA-125 compared with the highest quartile showed elevated values of most of metabolic parameters. In addition, as the quartile of CA-125 increased, metabolic derangement decreased. Increased numbers o... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5350735 Sat, 01 Oct 2011 04:00:00 +0100 5350735 http://www.medworm.com/index.php?rid=5350734&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22022187%26dopt%3DAbstract Authors: Hong SH, Kim JE, Cho ML, Heo YJ, Choi JH, Choi JH, Lee J Abstract The aim of this study was to evaluate and compare the Child-Turcotte-Pugh (CTP) classification system and the model for end-stage liver disease (MELD) score in predicting the severity of the systemic inflammatory response in living-donor liver transplantation patients. Recipients of liver graft were allocated to a recipient group (n = 39) and healthy donors to a donor group (n = 42). The association between the CTP classification, the MELD scores and perioperative cytokine concentrations in the recipient group was evaluated. The pro-inflammatory cytokines measured included interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α; the anti-inflammatory cytokines measured included IL-10 and IL-4. Cytokin... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5350734 Sat, 01 Oct 2011 04:00:00 +0100 5350734 http://www.medworm.com/index.php?rid=5350733&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22022188%26dopt%3DAbstract Authors: Jeong JH, Lee HL, Kim JO, Tae HJ, Jung SH, Lee KN, Jun DW, Lee OY, Yoon BC, Choi HS, Hahm JS, Song SY Abstract The aim of this study was to examine the relationship of complications related to diverticulitis and visceral obesity. The study was based on a retrospective case note review conducted at the Hanyang University Hospital. Patients were diagnosed with diverticulitis based on clinical symptoms and abdominal computed tomography (CT) findings and divided into two groups: those admitted with complicated diverticulitis and those with a simple diverticulitis episode. We compared the body mass index (BMI) and degree of visceral obesity, measured by abdominal CT. The study included 140 patients, 87 (62.1%) were simple diverticulitis and 53 (37.9%) were complicated diverticu... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5350733 Sat, 01 Oct 2011 04:00:00 +0100 5350733 http://www.medworm.com/index.php?rid=5350732&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22022189%26dopt%3DAbstract Authors: Paek SH, Lee JY, Kim HJ, Kang D, Lim YH, Kim MR, Kim C, Jeon BS, Kim DG Abstract We compared the surgical outcome with electrode positions after bilateral subthalamic nucleus (STN) stimulation surgery for Parkinson's disease. Fifty-seven patients treated with bilateral STN stimulations were included in this study. Electrode positions were determined in the fused images of preoperative MRI and postoperative CT taken at six months after surgery. The patients were divided into three groups: group I, both electrodes in the STN; group II, only one electrode in the STN; group III, neither electrode in the STN. Unified Parkinson's Disease Rating Scale (UPDRS), Hoehn and Yahr stage, and activities of daily living scores significantly improved at 6 and 12 months after STN stimulati... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5350732 Sat, 01 Oct 2011 04:00:00 +0100 5350732 http://www.medworm.com/index.php?rid=5350731&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22022190%26dopt%3DAbstract In conclusion, the present findings suggest that in the Korean population, the MTHFR polymorphisms are unlikely to be associated with the risk for schizophrenia and neurodevelopmental abnormalities related to schizophrenia. PMID: 22022190 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5350731 Sat, 01 Oct 2011 04:00:00 +0100 5350731 http://www.medworm.com/index.php?rid=5350730&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22022191%26dopt%3DAbstract Authors: Moon J, Kim YC, Park SY, Lee SC, Choi SP, Nahm FS, Lee PB, Goo EK, Kang JM Abstract The aims of this study were; 1) to develop the final version of the Korean Roland-Morris Disability Questionnaire (RDQ), and 2) to compare the responsiveness between the RDQ and the Oswestry Disability Index (ODI) scores in patients having low back pain. The psychometric properties of the final Korean RDQ were evaluated in 221 patients. Among them, 30 patients were reliability tested. Validity was evaluated using an 11-point numerical rating scale (NRS) and the Korean ODI. The receiver operating characteristic (ROC) curve analysis of the RDQ and the ODI was compared in 54 patients with lumbar zygapophyseal (facet) joint pain. There was a moderate relationship between the RDQ and NRS (r = 0.... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5350730 Sat, 01 Oct 2011 04:00:00 +0100 5350730 http://www.medworm.com/index.php?rid=5350729&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22022192%26dopt%3DAbstract Authors: Lee IO, Son JK, Lim ES, Kim YS Abstract Glycine and γ-aminobutyric acid (GABA) are localized and released by the same interneurons in the spinal cord. Although the effects of glycine and GABA on analgesia are well known, little is known about the effect of GABA in strychnine-induced hyperalgesia. To investigate the effect of GABA and the role of the glycine receptor in thermal hyperalgesia, we designed an experiment involving the injection of muscimol (a GABA(A) receptor agonist), baclofen (a GABA(B) receptor agonist) or glycine with strychnine (strychnine sensitive glycine receptor antagonist). Glycine, muscimol, or baclofen with strychnine was injected into the cisterna magna or lumbar subarachnoidal spaces of mice. The effects of treatment on strychnine-induced heat hy... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5350729 Sat, 01 Oct 2011 04:00:00 +0100 5350729 http://www.medworm.com/index.php?rid=5350728&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22022193%26dopt%3DAbstract Authors: Yildirim FB, Sarikcioglu L, Nakajima K Abstract A bilateral gastrocnemius tertius muscle and a unilateral accessory soleus muscle were encountered during the routine educational dissection studies. The right gastrocnemius tertius muscle consisted of one belly, but the left one of two bellies. On the left side, the superficial belly of the gastrocnemius tertius muscle had its origin from an area just above the tendon of the plantaris muscle, the deep belly from the tendon of the plantaris muscle. The accessory soleus muscle originated from the posteromedial aspect of the tibia and soleal line of the tibia and inserted to the medial surface of the calcaneus. On the right side, the gastrocnemius tertius muscle had its origin from the lateral condyle of the femur, and inserted... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5350728 Sat, 01 Oct 2011 04:00:00 +0100 5350728 http://www.medworm.com/index.php?rid=5350727&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22022194%26dopt%3DAbstract Authors: Yoo SJ, Ku MJ, Cho SS, Yoon SP Abstract Anatomical variations of the inferior mesenteric artery are extremely uncommon, since the inferior mesenteric artery is regularly diverged at the level of the third lumbar vertebra. We found a rare case in which the inferior mesenteric artery arose from the superior mesenteric artery. The findings were made during a routine dissection of the cadaver of an 82-yr-old Korean woman. This is the tenth report on this anomaly, the second female and the first Korean. The superior mesenteric artery normally arising from abdominal aorta sent the inferior mesenteric artery as the second branch. The longitudinal anastomosis vessels between the superior mesenteric artery and inferior mesenteric artery survived to form the common mesenteric artery... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5350727 Sat, 01 Oct 2011 04:00:00 +0100 5350727 http://www.medworm.com/index.php?rid=5350726&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22022195%26dopt%3DAbstract Authors: Kang SM, Kim WJ, Lee KA, Baek HS, Park TS, Jin HY Abstract A 29-yr-old man, presented with abdominal pain and fever, had an initial computed tomography (CT) scan revealing low attenuation of both adrenal glands. The initial concern was for tuberculous adrenalitis or autoimmune adrenalitis combined with adrenal hemorrhage. The patient started empirical anti-tuberculous medication, but there was no improvement. Enlargement of cervical lymph nodes were developed after that and excisional biopsy of cervical lymph nodes was performed. Pathological finding of excised lymph nodes was compatible to NK/T-cell lymphoma. The patient died due to the progression of the disease even after undergoing therapeutic trials including chemotherapy. Lymphoma mainly involving adrenal gland in th... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5350726 Sat, 01 Oct 2011 04:00:00 +0100 5350726 http://www.medworm.com/index.php?rid=5350725&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22022196%26dopt%3DAbstract We describe the first case of PAM in Korea. A 19-yr-old man without respiratory symptoms presented with interstitial thickening on the chest radiograph. His chest high resolution CT scan showed diffusely scattered, ill defined tiny micronodules and interstitial thickening. Open lung biopsy confirmed the diagnosis of PAM. He was followed up for 6 months without treatment, and no progression was noticed. PMID: 22022196 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5350725 Sat, 01 Oct 2011 04:00:00 +0100 5350725 http://www.medworm.com/index.php?rid=5350724&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22022197%26dopt%3DAbstract This report shows potential management of ovarian hyperstimulation following the administration of GnRHa without gonadotropins. PMID: 22022197 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5350724 Sat, 01 Oct 2011 04:00:00 +0100 5350724 http://www.medworm.com/index.php?rid=5350723&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22022198%26dopt%3DAbstract Authors: Kim TY PMID: 22022198 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5350723 Sat, 01 Oct 2011 04:00:00 +0100 5350723 http://www.medworm.com/index.php?rid=5350722&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22022199%26dopt%3DAbstract Authors: Kang HJ, Youn YK, Hong MK, Kim LS PMID: 22022199 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5350722 Sat, 01 Oct 2011 04:00:00 +0100 5350722 http://www.medworm.com/index.php?rid=5350721&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22022200%26dopt%3DAbstract Authors: Kim MJ, Choi JR, Suh JT, Lee HJ, Lee WI, Park TS PMID: 22022200 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5350721 Sat, 01 Oct 2011 04:00:00 +0100 5350721 http://www.medworm.com/index.php?rid=5350720&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22022201%26dopt%3DAbstract Authors: Choi HJ, Kim HR, Shin MG PMID: 22022201 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5350720 Sat, 01 Oct 2011 04:00:00 +0100 5350720 http://www.medworm.com/index.php?rid=5269761&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21935264%26dopt%3DAbstract Authors: Chang JY, Lee KS, Hahn WH, Chung SH, Choi YS, Shim KS, Bae CW Abstract Neonatal mortality rate (NMR) and infant mortality rate (IMR) are two of the most important indices reflecting the level of public health of a country. In this review, we investigated changes in NMR and IMR in Korea and compared the results with those of Japan, USA, and OECD nations. During the past 20 yr, NMR and IMR have lowered remarkably from 6.6 and 9.9 in 1993 to 1.7 and 3.2 in 2009, respectively, in Korea. It is an impressive finding that Korean IMR (3.2 in 2009) is lower than the average of OECD nations (4.7 in 2008), and USA (6.3 in 2009), although higher than Japanese IMR (2.8 in 2009). The proportion of NMR among the IMR calculation decreased from 66.7% in 1993 to 53.1% in 2009. The reason th... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5269761 Thu, 01 Sep 2011 04:00:00 +0100 5269761 http://www.medworm.com/index.php?rid=5269760&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21935265%26dopt%3DAbstract In conclusion, a relatively high prevalence of short sleep duration is identified in this population of Korean adults. Factors associated with short or long sleep may act as potential confounders of the relationship between sleep duration and health outcomes. PMID: 21935265 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5269760 Thu, 01 Sep 2011 04:00:00 +0100 5269760 http://www.medworm.com/index.php?rid=5269759&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21935266%26dopt%3DAbstract Authors: Hong YS, Moon SJ, Joo YB, Jeon CH, Cho ML, Ju JH, Oh HJ, Heo YJ, Park SH, Kim HY, Min JK Abstract The interleukin-33 (IL-33)/ST2 pathway has emerged as an intercellular signaling system that participates in antigen-allergen response, autoimmunity and fibrosis. It has been suggested that IL-33/ST2 signaling has been involved in the pathogenesis of rheumatoid arthritis (RA), because IL-33 and its receptor have been specifically mapped to RA synovium. The aim of this study was to determine the levels of IL-33 and sST2 in sera and synovial fluids in patients with RA. The serum level of IL-33 was significantly higher in patients with RA (294.9 ± 464.0 pg/mL) than in healthy controls (96.0 ± 236.9 pg/mL, P = 0.002). The synovial fluid level of IL-33 was significantly higher in... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5269759 Thu, 01 Sep 2011 04:00:00 +0100 5269759 http://www.medworm.com/index.php?rid=5269758&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21935267%26dopt%3DAbstract In conclusion, the prevalence of knee pain is high (32.2% in men and 58.0% in women) in this elderly community population in Korea. Independent of knee OA and other confounding factors, subjects with knee pain have more than 5-fold increase in the risk of belonging to the worst lower extremity function compared to subjects without knee pain. PMID: 21935267 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5269758 Thu, 01 Sep 2011 04:00:00 +0100 5269758 http://www.medworm.com/index.php?rid=5269756&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21935268%26dopt%3DAbstract Authors: Joo K, Park W, Lim MJ, Kwon SR, Yoon J Abstract Early differentiation between bacterial infections and disease flares in autoimmune disease patients is important due to different treatments. Seventy-nine autoimmune disease patients with symptoms suggestive of infections or disease flares were collected by retrospective chart review. The patients were later classified into two groups, disease flare and infection. C-reactive protein (CRP) and serum procalcitonin (PCT) levels were measured. The CRP and PCT levels were higher in the infection group than the disease flare group (CRP,11.96 mg/dL ± 9.60 vs 6.42 mg/dL ± 7.01, P = 0.003; PCT, 2.44 ng/mL ± 6.55 vs 0.09 ng/mL ± 0.09, P < 0.001). The area under the ROC curve (AUC; 95% confidence interval) for CRP and PCT was 0.... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5269756 Thu, 01 Sep 2011 04:00:00 +0100 5269756 http://www.medworm.com/index.php?rid=5269751&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21935269%26dopt%3DAbstract In conclusion, half of the children younger than 24 months of age with AD and cow's milk allergy could tolerate cow's milk at 67 months of age. The peak cow's milk-specific IgE level within the first 24 months of birth is useful to predict the prognosis of cow's milk allergy in children with AD. PMID: 21935269 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5269751 Thu, 01 Sep 2011 04:00:00 +0100 5269751 http://www.medworm.com/index.php?rid=5269749&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21935270%26dopt%3DAbstract In conclusion, ASAI was safe and well tolerated in patients with AD. ASAI can be a useful therapeutic option for AD. PMID: 21935270 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5269749 Thu, 01 Sep 2011 04:00:00 +0100 5269749 http://www.medworm.com/index.php?rid=5269748&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21935271%26dopt%3DAbstract In conclusion, the sensitization rate is 47.9% and house dust mite is the most prevalent allergen in the pediatric population in Korea. The rate is higher in metropolitan areas and the highest income group than in rural areas and low income groups. PMID: 21935271 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5269748 Thu, 01 Sep 2011 04:00:00 +0100 5269748 http://www.medworm.com/index.php?rid=5269747&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21935272%26dopt%3DAbstract Authors: Roh YN, Woo SY, Kim N, Kim S, Kim YW, Kim DI Abstract We attempted to investigate the prevalence and risk factors of carotid artery stenosis in Korea. Twenty thousand seven hundred twelve individuals who underwent carotid artery ultrasonography for health screening between March 2005 and March 2010 were retrospectively evaluated. The population was divided into four groups, according to the degree of stenosis, as Group A, below 29%; Group B, 30% to 49%; Group C, 50% to 74%; Group D, above 75%. The medical records of the individuals were investigated, and Fisher's exact test, chi-square tests, Kruskal-Wallis tests and a binary logistic regression model were used for statistical analysis. The prevalence of carotid stenosis was Group B, 5.5%; Group C, 0.9%; Group D, 0.1%. Old... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5269747 Thu, 01 Sep 2011 04:00:00 +0100 5269747 http://www.medworm.com/index.php?rid=5269746&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21935273%26dopt%3DAbstract Authors: Kim KI, Park KU, Chun EJ, Choi SI, Cho YS, Youn TJ, Cho GY, Chae IH, Song J, Choi DJ, Kim CH Abstract DKK1 modulates Wnt signaling, which is involved in the atherosclerosis. However, no data exist regarding the usefulness of measuring serum DKK1 concentration in predicting coronary atherosclerosis. A total of 270 consecutive patients (62.8 ± 11.2 yr; 70% male) were included. A contrast-enhanced 64-slice coronary MDCT was performed to identify the presence of atherosclerotic plaques. Agatston calcium scores (CS) were calculated to quantify the coronary artery calcification (CAC). DKK1 concentrations were measured by enzyme-linked immunosorbent assay. For each subsequent DKK1 quartile, there was a significant increase in CAC (P = 0.004) and the number of segments with coron... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5269746 Thu, 01 Sep 2011 04:00:00 +0100 5269746 http://www.medworm.com/index.php?rid=5269745&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21935274%26dopt%3DAbstract This study included 102 patients with an estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73 m(2). Ambulatory blood pressure monitoring and echocardiography were performed at the beginning of the study, and the serum creatinine levels were followed. During the average follow-up period of 51 months, CKD developed in 11 patients. There was a significant difference in the incidence of CKD between dippers and non-dippers (5.0% vs 19.0%, P < 0.05). Compared to patients without CKD, patients with incident CKD had a higher urine albumin/creatinine ratio (52.3 ± 58.6 mg/g vs 17.8 ± 29.3 mg/g, P < 0.01), non-dipper status (72.7% vs 37.4%, P < 0.05), the presence of LVH (27.3% vs 5.5%, P < 0.05), and a lower serum HDL-cholesterol level (41.7 ± 8.3 mg/dL vs 50.4 ± 12.4 mg/d... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5269745 Thu, 01 Sep 2011 04:00:00 +0100 5269745 http://www.medworm.com/index.php?rid=5269744&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21935275%26dopt%3DAbstract Authors: Yim JH, Yoon JH, Kim SA, Kim WG, Jeon MJ, Han JM, Sung TY, Kim TY, Bae Kim W, Hong SJ, Shong YK, Gong G Abstract X-linked inhibitor of apoptosis protein (XIAP) is associated with tumor genesis, growth, progression and metastasis, and acts by blocking caspase-mediated apoptosis. In the present study, we sought to evaluate the expression patterns of XIAP in various neoplastic thyroid disorders and determine the association between XIAP expression and clinicopathologic factors. Expression of XIAP was evaluated with immunohistochemical staining using monoclonal anti-XIAP in 164 specimens of conventional papillary thyroid carcinoma (PTC) and 53 specimens of other malignant or benign thyroid tumors. XIAP positivity was observed in 128 (78%) of the 164 conventional PTC specimens.... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5269744 Thu, 01 Sep 2011 04:00:00 +0100 5269744 http://www.medworm.com/index.php?rid=5269743&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21935276%26dopt%3DAbstract Authors: Suh S, Kang M, Kim MY, Chung HS, Kim SK, Hur KY, Kim JH, Lee MS, Lee MK, Kim KW Abstract We tested the correlation between diabetes and aggressiveness of colorectal polyps in diabetic patients and matched non-diabetic controls. We retrospectively studied 3,505 type 2 diabetes (T2DM) patients without gastrointestinal symptoms who underwent colonoscopy for colorectal cancer at Samsung Medical Center, Seoul, Korea from August 1995 to August 2009. We matched 495 non-diabetic subjects with colon polyps to the diabetic patients in whom polyps were detected by year of colonoscopy, age, sex and body mass index (BMI). Among the 3,505 T2DM patients screened, 509 were found to have 1,136 colon polyps. Those with diabetes had a greater proportion of adenomatous polyps (62.8% vs 53.6%)... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5269743 Thu, 01 Sep 2011 04:00:00 +0100 5269743 http://www.medworm.com/index.php?rid=5269742&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21935277%26dopt%3DAbstract Authors: Lim JH, Lee YS, Chang HC, Moon MK, Song Y Abstract We aimed to explore the associations of dietary patterns with blood lipid profiles and obesity in adults with type 2 diabetes. The data were obtained from the Forth Korean National Health and Nutrition Examination Survey, 2007-2008. Adults 30 yr or older, from which had both biochemical and dietary data were obtained. Among them, 680 subjects were defined as having diabetes based on criteria of fasting glucose ≥ 126 mg/dL, anti-diabetic treatment, or previously diagnosed diabetes. Dietary data from a 24-hr recall were used to derive dietary patterns by factor analysis. Four dietary patterns by factor analysis were identified: 'Bread & Meat & Alcohol', 'Noodles & Seafood', 'Rice & Vegetables', and 'Korean ... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5269742 Thu, 01 Sep 2011 04:00:00 +0100 5269742 http://www.medworm.com/index.php?rid=5269741&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21935278%26dopt%3DAbstract Authors: Kang HW, Kim TO, Lee BR, Yu JY, Chi SY, Ban HJ, Oh IJ, Kim KS, Kwon YS, Kim YI, Kim YC, Lim SC Abstract A reduction in diaphragm mobility has been identified in patients with chronic obstructive pulmonary disease (COPD) and has been associated with a decline in pulmonary function parameters. However, little information exists regarding the potential role of diaphragm mobility on hypercapnia in COPD. A new method of assessing the mobility of the diaphragm, using ultrasound, has recently been validated. The purpose of the present study was to investigate the relationship between diaphragm mobility and pulmonary function parameters, as well as that between arterial blood gas values and diaphragm mobility, in COPD patients. Thirty seven COPD patients were recruited for pulmona... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5269741 Thu, 01 Sep 2011 04:00:00 +0100 5269741 http://www.medworm.com/index.php?rid=5269740&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21935279%26dopt%3DAbstract Authors: Park HK, Na DL, Han SH, Kim JY, Cheong HK, Kim SY, Kim SY, Hong CH, Kim DK, Ku BD, Moon SY, Lee JY, Shim YS, Youn YC, Kim EJ, Kim BC, Park KH, Cha KR, Seo SW, Lee JH Abstract With rapid population aging, the socioeconomic burden caused by dementia care is snowballing. Although a few community-based studies of Alzheimer's disease (AD) have been performed in Korea, there has never been a nationwide hospital-based study thereof. We aimed to identify the demographics and clinical characteristics of mild-to-moderate AD patients from the Clinical Research Center for Dementia of Korea (CREDOS) registry. A total of 1,786 patients were consecutively included from September 2005 to June 2010. Each patient underwent comprehensive neurological examination, interview for caregivers, la... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5269740 Thu, 01 Sep 2011 04:00:00 +0100 5269740 http://www.medworm.com/index.php?rid=5269738&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21935280%26dopt%3DAbstract This study was designed to identify the causes of the development of carpal tunnel syndrome (CTS) associated with end stage kidney disease (ESKD). A total of 112 patients with ESKD, 64 on hemodialysis (HD) and 48 on peritoneal dialysis (PD), were enrolled. The duration of ESKD and dialysis, the site of the arteriovenous (A-V) fistula for HD, laboratory data such as blood urea nitrogen, creatinine, and beta-2-microglobulin were determined. Clinical evaluation of CTS and electrophysiological studies for the diagnosis of CTS and peripheral neuropathy were performed. The electrophysiological studies showed that the frequency of CTS was not different in the HD and PD groups (P = 0.823) and the frequency of CTS was not different in the limb with the A-V fistula compared to the contralateral limb... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5269738 Thu, 01 Sep 2011 04:00:00 +0100 5269738 http://www.medworm.com/index.php?rid=5269735&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21935281%26dopt%3DAbstract In conclusion, we believe that Demodex plays an aggravating role in inflammatory ocular surface disorders. PMID: 21935281 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5269735 Thu, 01 Sep 2011 04:00:00 +0100 5269735 http://www.medworm.com/index.php?rid=5269734&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21935282%26dopt%3DAbstract Authors: Kim YH, Cho JT Abstract Acute renal failure with severe loin pain which develops after anaerobic exercise is rare. One of predisposing factors of exercise-induced acute renal failure is renal hypouricemia. Idiopathic renal hypouricemia is a genetic disorder characterized by hypouricemia with abnormally high renal tubular uric acid excretion. The mutation in SCL22A12 gene which encodes renal uric acid transporter, URAT1, is the known major cause of this disorder. We here described a 25-yr-old man showing idiopathic renal hypouricemia with G774A mutation in SCL22A12 who presented exercise-induced acute renal failure. There have been a few reports of mutational analysis in Korean idiopathic renal hypouricemia without acute renal failure. This is the first report of geneticall... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5269734 Thu, 01 Sep 2011 04:00:00 +0100 5269734 http://www.medworm.com/index.php?rid=5269733&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21935283%26dopt%3DAbstract Authors: Raheem OA, Jeong YB Abstract Since urethral Foley catheterization is usually easy and safe, serious complications related to this procedure have been rarely reported. Herein, we describe a case of intraperitoneally placed urethral catheter via verumontanum presenting as intraperitoneal bladder perforation in a chronically debilitated elderly patient. A 82-yr-old male patient was admitted with symptoms of hematuria, lower abdominal pain after traumatic Foley catheterization. The retrograde cystography showed findings of intraperitoneal bladder perforation, but emergency laparotomy with intraoperative urethrocystoscopy revealed a tunnel-like false passage extending from the verumontanum into the rectovesical pouch between the posterior wall of the bladder and the anterior wa... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5269733 Thu, 01 Sep 2011 04:00:00 +0100 5269733 http://www.medworm.com/index.php?rid=5269732&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21935284%26dopt%3DAbstract Authors: Lee JH, Ki CS, Kim DS, Cho JW, Park KP, Kim S Abstract Dopa-responsive dystonia (DRD) is a clinical syndrome characterized by childhood-onset dystonia and a dramatic response to relatively low doses of levodopa. However, patients with DRD can be misdiagnosed as cerebral palsy or spastic diplegia due to phenotypic variation. Here we report a young woman with DRD who were severely disabled and misdiagnosed as cerebral palsy for over 10 yr. A small dose of levodopa restored wheelchair-bound state to normality. However, thoracolumbar scoliosis has remained as a sequel due to late detection of DRD. Genetic analysis by using PCR-direct sequencing revealed a novel initiation codon mutation (c.1A>T; p.Met1Leu) in GTP cyclohydrolase 1 (GCH1) gene. Although it is known that DRD c... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5269732 Thu, 01 Sep 2011 04:00:00 +0100 5269732 http://www.medworm.com/index.php?rid=5269731&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21935285%26dopt%3DAbstract Authors: Lee JH, Kim DH, Yoo K, Choi Y, Kim SH, Kim HJ Abstract Acquired hemophilia A (AHA) is a rare coagulopathy caused by autoantibodies to coagulation factor VIII (FVIII). Most patients with AHA have been previously healthy; however, a variety of morbidities have been associated with the condition including pregnancy. A 40-yr-old woman visited our institution with extensive hematoma on the right hip area. Her medical history revealed no personal or familial history of bleeding diathesis. Her coagulation tests showed markedly prolonged aPTT (117 sec), markedly decreased level of FVIII activity (0.4%) and high-titer FVIII inhibitor (77 BU). Collectively, she was diagnosed as having postpartum AHA and was treated with bypassing agents and corticosteroids. Her aPTT was normalized o... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5269731 Thu, 01 Sep 2011 04:00:00 +0100 5269731 http://www.medworm.com/index.php?rid=5269730&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21935286%26dopt%3DAbstract Authors: Das S PMID: 21935286 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5269730 Thu, 01 Sep 2011 04:00:00 +0100 5269730 http://www.medworm.com/index.php?rid=5269728&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21935287%26dopt%3DAbstract Authors: Yoo SD, Bark J PMID: 21935287 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5269728 Thu, 01 Sep 2011 04:00:00 +0100 5269728 http://www.medworm.com/index.php?rid=5269727&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21949470%26dopt%3DAbstract Authors: Kim WT, Yun SJ, Choi YD, Kim GY, Moon SK, Choi YH, Kim IY, Kim WJ Abstract We evaluated the correlations between BMI, fasting glucose, insulin, testosterone level, insulin resistance, and prostate size in non-diabetic benign prostatic hyperplasia (BPH) patients with normal testosterone levels. Data from 212 non-diabetic BPH patients with normal testosterone levels, who underwent transurethral resection of the prostate (TURP) due to medical treatment failure, were evaluated retrospectively. Patients with prostate specific antigen (PSA) levels of ≥ 3 ng/mL underwent multicore transrectal prostate biopsy before TURP to rule out prostate cancer. Patients with diabetes mellitus (DM) or serum testosterone levels of < 3.50 ng/mL were excluded from analysis. Correlations betw... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5269727 Thu, 01 Sep 2011 04:00:00 +0100 5269727 http://www.medworm.com/index.php?rid=5164620&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21860544%26dopt%3DAbstract Authors: Yun KW, Cho EY, Hong KB, Choi EH, Lee HJ Abstract The purpose of this study was to develop pneumococcal typing by multiplex PCR and compare it with conventional serotyping by quellung reaction. Pneumococcal strains used in this study included 77 isolates from clinical specimens collected from children at Seoul National University Children's Hospital from 2006 to 2010. These strains were selected as they represented 26 different serotypes previously determined by quellung reaction. Molecular type was determined by 8 sequential multiplex PCR assays. Bacterial DNA extracted from cultured colonies was used as a template for PCR, and primers used in this study were based on cps operon sequences. Types 6A, 6B, 6C, and 6D were assigned based on the presence of wciN(β) and/or wci... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5164620 Sun, 31 Jul 2011 23:00:00 +0100 5164620 http://www.medworm.com/index.php?rid=5164615&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21860545%26dopt%3DAbstract In conclusion, patients with advanced age, intraoperative RBC transfusion, postoperative complications other than pneumonia and a decreased FEV(1)/FVC ratio have a higher risk for pneumonia after lung cancer surgery. PMID: 21860545 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5164615 Sun, 31 Jul 2011 23:00:00 +0100 5164615 http://www.medworm.com/index.php?rid=5164598&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21860546%26dopt%3DAbstract In conclusion, the clinical characteristics of RPF in Korean patients are similar with other series except for higher proportion of male. Some patients with RPF have autoimmune features. The effect of immunosuppressive treatment on RPF is good. PMID: 21860546 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5164598 Sun, 31 Jul 2011 23:00:00 +0100 5164598 http://www.medworm.com/index.php?rid=5164597&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21860547%26dopt%3DAbstract Authors: Ryu RA, Tae K, Min HJ, Jeong JH, Cho SH, Lee SH, Ahn YH Abstract Polymorphisms of DNA repair genes, X-ray repair cross-complementing group 1 (XRCC1) might contribute to individual susceptibility to different types of cancers. We analyzed the relationship between XRCC1 polymorphisms and the risk of papillary thyroid carcinoma in a Korean sample. A hospital-based case-control study was performed in 111 papillary thyroid carcinoma patients and 100 normal control subjects. XRCC1 Arg194Trp and Arg399Gln single nucleotide polymorphisms (SNPs) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The XRCC1 Arg194Trp Arg/Trp genotype was significantly associated with a decreased risk of papillary thyroid carcinoma compared to that of Arg/... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5164597 Sun, 31 Jul 2011 23:00:00 +0100 5164597 http://www.medworm.com/index.php?rid=5164596&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21860548%26dopt%3DAbstract In this study, 161 consecutive patients were included in the training data set. This scoring system, named the Yonsei Estimated Value (YEV) for lymph node metastasis in papillary thyroid cancer, was developed on the basis of results from multivariate logistic regression analysis of preoperative clinical and radiologic data. Sixty eight consecutive patients were included for testing of the validity of the scoring system. The equation for prediction of lateral neck node metastasis was follows:YEV (Yonsei Estimated Value) = 1/(1+X)X = Exp (5.333-[0.902 × sex]+[0.036 × age]-[1.020 × tumor size]-[0.177 × lymph node size]-[0.032 × lymph node density])When the YEV was 0.3 or more, the probability of lateral neck node metastasis was 79.0%, with sensitivity of 76.3%, specificity of 69.8%, posi... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5164596 Sun, 31 Jul 2011 23:00:00 +0100 5164596 http://www.medworm.com/index.php?rid=5164595&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21860549%26dopt%3DAbstract In conclusion, HER-2 gene heterogeneity of invasive breast cancer is identified in routine FISH examination. This may affect the results of HER-2 gene amplification status in FISH studies. PMID: 21860549 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5164595 Sun, 31 Jul 2011 23:00:00 +0100 5164595 http://www.medworm.com/index.php?rid=5164594&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21860550%26dopt%3DAbstract Authors: Park HS, Choi JY, Lee MJ, Park S, Yeo CW, Lee SS, Shin JG, Park BW Abstract The aim of the study was to evaluate the association between genetic polymorphisms of CYP2D6 and outcomes in breast cancer patients with tamoxifen treatment. We evaluated the CYP2D6 genetic polymorphisms in 766 breast cancer patients. Among them, 110 patients whose samples were prospectively collected before surgery and treated with tamoxifen were included to evaluate the association between CYP2D6 and outcomes. The genotypes of CYP2D6 were categorized as extensive metabolizer (EM), intermediate metabolizer (IM), and poor metabolizer (PM) according to the activity score. The clinicopathologic features of 110 patients were not significantly different among the three groups except for the T-stage and... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5164594 Sun, 31 Jul 2011 23:00:00 +0100 5164594 http://www.medworm.com/index.php?rid=5164593&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21860551%26dopt%3DAbstract Authors: Yu JI, Park HC, Lim do H, Park W, Yoo BC, Paik SW, Koh KC, Lee JH Abstract We performed a retrospective review of 281 hepatocellular carcinoma (HCC) patients with portal vein tumor thrombosis (PVTT) treated with radiation therapy (RT) between 1998 and 2008 to develop a prognostic model for those patients. Of the 281 patients, PVTT and intrahepatic main masses completely disappeared in 10 patients (3.6%), and shown a partial response in 141 patients (50.2%). The median survival was 11.6 months. Patients who had more than PR have shown significantly longer survival than the others (22.0 months vs 5.0 months, P < 0.001). On the multivariate analysis, pre-treatment poor prognosticators for overall survival were ECOG performance status, Child-Pugh class, multiple tumors, mai... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5164593 Sun, 31 Jul 2011 23:00:00 +0100 5164593 http://www.medworm.com/index.php?rid=5164592&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21860552%26dopt%3DAbstract In conclusion, an awareness of the clinicopathologic features, specifically the various morphologic features of intermediate areas in this tumor, is essential for prevention of potential misdiagnosis as another tumor. PMID: 21860552 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5164592 Sun, 31 Jul 2011 23:00:00 +0100 5164592 http://www.medworm.com/index.php?rid=5164591&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21860553%26dopt%3DAbstract In conclusion, 'A-family' seems preferable to 'S-family' if both approaches are feasible. When two-stent strategy is used, every effort should be made to perform FKI, especially in 'S-family'. PMID: 21860553 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5164591 Sun, 31 Jul 2011 23:00:00 +0100 5164591 http://www.medworm.com/index.php?rid=5164590&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21860554%26dopt%3DAbstract In conclusion, preoperative aspirin resistance does not increase myocardial injury in patients undergoing off-pump coronary artery bypass surgery. Postoperative dual antiplatelet therapy might have protected aspirin resistant patients. PMID: 21860554 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5164590 Sun, 31 Jul 2011 23:00:00 +0100 5164590 http://www.medworm.com/index.php?rid=5164588&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21860555%26dopt%3DAbstract In conclusion, the overall feasibility rate for EVAR in Korean patients was not different from that in Western patients. However, considering the difference in the major causes of unsuitability, more attention has to be paid to neck angulation and CIA aneurysm to provide EVAR for more Korean patients especially who have large aneurysm. PMID: 21860555 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5164588 Sun, 31 Jul 2011 23:00:00 +0100 5164588 http://www.medworm.com/index.php?rid=5164586&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21860556%26dopt%3DAbstract Authors: Choi YH, Hong YJ, Park IH, Jeong MH, Ahmed K, Hwang SH, Lee MG, Park KH, Sim DS, Kim JH, Ahn Y, Cho JG, Park JC, Kang JC Abstract The aim of this study was to evaluate the relationship between coronary artery calcium score (CACS) assessed by multidetector computed tomography (MDCT) and plaque components assessed by virtual histology-intravascular ultrasound (VH-IVUS) in 172 coronary artery disease (CAD) patients with 250 coronary lesions. CACS was assessed according to Agatston scoring method by MDCT and patients were divided into four groups: Group I (CACS = 0 [n = 52]); Group II (CACS = 1-100 [n = 99]); Group III (CACS = 101-400 [n = 84]); and Group IV (CACS > 400 [n = 15]). Total atheroma volume was greatest in Group IV (152 ± 132 µL vs 171 ± 114 µL vs 195 ± 149... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5164586 Sun, 31 Jul 2011 23:00:00 +0100 5164586 http://www.medworm.com/index.php?rid=5164583&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21860557%26dopt%3DAbstract Authors: Shin SJ, Lim CY, Rhee MY, Oh SW, Na SH, Park Y, Kim CI, Kim SY, Kim JW, Park HK Abstract Sodium sensitivity (SS) is a variable response of blood pressure (BP) to changes in sodium intake. The present study evaluated the existence and the characteristics of subjects with SS in Koreans. One hundred one subjects with (n = 31, 57.7 ± 9.8 yr) or without hypertension (n = 70, 40.8 ± 16.5 yr) were given a low-sodium dietary approache to stop hypertension (DASH) diet (LSD) for 7 days and a high-sodium DASH diet (HSD) for the following 7 days. The prevalence of SS in the present study population was 27.7% (17.6% in the non-hypertensive subjects and 51.6% in the hypertensive subjects). Analysis of the non-hypertensive subjects showed that systolic BP, diastolic BP, and mean arteri... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5164583 Sun, 31 Jul 2011 23:00:00 +0100 5164583 http://www.medworm.com/index.php?rid=5164582&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21860558%26dopt%3DAbstract This study was aimed to investigate the prevalence of diabetic retinopathy and its associated factors in rural Korean patients with type 2 diabetes. A population-based, cross-sectional diabetic retinopathy survey was conducted from 2005 to 2006 in 1,298 eligible participants aged over 40 yr with type 2 diabetes identified in a rural area of Chungju, Korea. Diabetic retinopathy was diagnosed by a practicing ophthalmologist using funduscopy. The overall prevalence of diabetic retinopathy in the population was 18% and proliferative or severe non-proliferative form was found in 5.0% of the study subjects. The prevalence of retinopathy was 6.2% among those with newly diagnosed type 2 diabetes and 2.4% of them had a proliferative or severe non-proliferative diabetic retinopathy. The odds ratio o... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5164582 Sun, 31 Jul 2011 23:00:00 +0100 5164582 http://www.medworm.com/index.php?rid=5164581&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21860559%26dopt%3DAbstract This study was conducted to compare the efficacy and safety of DA-9601 with misoprostol for preventing NSAID-associated gastroduodenal injury. In this randomized, double-blind, multicenter, noninferiority trial we compared the extents of protection of gastric and duodenal mucosae by endoscopy after 4 weeks of treatment with DA-9601 60 mg or misoprostol 200 µg three times daily, in subjects with normal baseline endoscopic findings who received an NSAID twice daily for 4 weeks. A total of 266 subjects were randomized to treatment. At week 4, the gastric protection rates with DA-9601 and misoprostol were 85.1% and 95.2%, respectively; the difference between the groups was -10.1% (var = 0.001), which was shown to indicate noninferiority of DA-9601 compared to misoprostol. Adverse events were ... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5164581 Sun, 31 Jul 2011 23:00:00 +0100 5164581 http://www.medworm.com/index.php?rid=5164580&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21860560%26dopt%3DAbstract Authors: Lee WJ, Park SE, Rah DK Abstract Keloids are pathologic proliferations of the dermal layer of the skin resulting from excessive collagen production and deposition. Hepatocyte growth factor (HGF) increases the expression of matrix metalloproteinase (MMP)-1 and suppresses collagen synthesis to modulate extracellular matrix turnover. To investigate the anti-fibrotic effects of HGF, we examine the mRNA expression of collagen types I and III and matrix metalloproteinase (MMP-1, MMP-3) on human dermal fibroblast (HDF) cell lines and keloid fibroblasts (KFs, n = 5) after adding various amount of HGF protein. We also evaluated the enzymatic activity of MMP-2, MMP-9 by zymograghy. In HDFs treated with TGF-β1 and HGF protein simultaneously, both type I and III collagen mRNA express... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5164580 Sun, 31 Jul 2011 23:00:00 +0100 5164580 http://www.medworm.com/index.php?rid=5164579&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21860561%26dopt%3DAbstract This study was performed on patient population, aged 50-yr or older who underwent surgical procedures because of hip fracture (ICD10; S720, S721). All patients were followed using patient identification code to identify deaths. Crude hip fracture rates increased from 191.9/100,000 in 2005 to 207.0/100,000 in 2008 in women and from 94.8/100,000 in 2005 to 97.8/100,000 in 2008, in men respectively. Crude mortality within 12 months after hip fracture showed a similar trend (18.8% in 2005 and 17.8% in 2007). The mean of standardized mortality ratio of hip fracture was 6.1 at 3 months, 3.5 at 1 yr, and 2.3 at 2 yr post-fracture. The increasing incidence and the high mortality after hip fracture are likely to become serious public health problems and a public health program should begin to preve... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5164579 Sun, 31 Jul 2011 23:00:00 +0100 5164579 http://www.medworm.com/index.php?rid=5164574&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21860562%26dopt%3DAbstract In conclusion, addition of vitamin K to vitamin D and calcium supplements in the postmenopausal Korean women increase the L3 BMD and reduce the UcOC concentration. PMID: 21860562 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5164574 Sun, 31 Jul 2011 23:00:00 +0100 5164574 http://www.medworm.com/index.php?rid=5164573&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21860563%26dopt%3DAbstract We report one case of a young adult male with primary mediastinal GCT who subsequently developed acute megakaryoblastic leukemia involving isochromosome (12p). A 25-yr-old man had been diagnosed with a mediastinal GCT and underwent surgical resection and adjuvant chemotherapy. At 1 week after the last cycle of chemotherapy, his peripheral blood showed leukocytosis with blasts. A bone marrow study confirmed the acute megakaryoblastic leukemia. A cytogenetic study revealed a complex karyotype with i(12p). Although additional chemotherapy was administered, the patient could not attain remission and died of septic shock. This case was definitely distinct from therapy-related secondary leukemia in terms of clinical, morphologic, and cytogenetic features. To our knowledge, this is the first case... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5164573 Sun, 31 Jul 2011 23:00:00 +0100 5164573 http://www.medworm.com/index.php?rid=5164572&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21860564%26dopt%3DAbstract Authors: Abdul-Ghafar J, Kim JW, Park KH, Cho MY Abstract The World Health Organization (WHO) recently defined systemic Epstein-Barr virus (EBV)-positive T-cell lymphoproliferative disorders (LPD) of childhood as a life-threatening illness. However, this rare disease has not been extensively studied. Here we report a case of systemic EBV-positive T-cell LPD in a previously healthy middle-aged man with a chief complaint of chronic diarrhea. The initial colon biopsy showed focal infiltration of EBV-positive small lymphocytes without any atypia. However, the disease rapidly progressed and the patient required a total colectomy due to severe gastrointestinal bleeding. Three and half months after admission, the patient died from a complication of disseminated intravascular coagulation. ... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5164572 Sun, 31 Jul 2011 23:00:00 +0100 5164572 http://www.medworm.com/index.php?rid=5164571&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21860565%26dopt%3DAbstract We report here a case of iatrogenic HPVG with a review of relevant literature. PMID: 21860565 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5164571 Sun, 31 Jul 2011 23:00:00 +0100 5164571 http://www.medworm.com/index.php?rid=5164570&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21860566%26dopt%3DAbstract We examined a three-year old Korean girl who had the typical clinical features of HVDRR including rickets, hypocalcemia, hypophosphatemia, elevated serum calcitriol level and secondary hyperparathyroidism. The girl and her father were both heterozygous for the 719 C-to-T (I146T) mutation in exon 4, whereas she and her mother were both heterozygous for 754 C-to-T (R154C) mutation in exon 5 of the VDR gene. In this familial study, we concluded that the girl had compound heterozygous mutations in her VDR gene which caused HVDRR. This is the first report of a unique mutation in the VDR gene in Korea. PMID: 21860566 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5164570 Sun, 31 Jul 2011 23:00:00 +0100 5164570 http://www.medworm.com/index.php?rid=5027278&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21738335%26dopt%3DAbstract This study was designed to identify novel genes that might help clarify the molecular mechanisms of chondrogenesis. Chondrogenesis was induced by culturing human bone marrow (BM) derived MSCs in micromass pellets in the presence of defined medium for 3, 7, 14 or 21 days. Several genes regulated during chondrogenesis were then identified by reverse transcriptase-polymerase chain reaction (RT-PCR). Using an ABI microarray system, we determined the differential gene expression profiles of differentiated chondrocytes and BM-MSCs. Normalization of this data resulted in the identification of 1,486 differentially expressed genes. To verify gene expression profiles determined by microarray analysis, the expression levels of 10 genes with high fold changes were confirmed by RT-PCR. Gene expression ... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5027278 Thu, 30 Jun 2011 23:00:00 +0100 5027278 http://www.medworm.com/index.php?rid=5027277&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21738336%26dopt%3DAbstract Authors: Choi HK, Kim KH, Lee SH, Lee SJ Recurrent Clostridium difficile infection (CDI) is one of the most difficult problems in healthcare infection control. We evaluated the risk factors associated with recurrence in patients with CDI. A retrospective cohort study of 84 patients with CDI from December 2008 through October 2010 was performed at Pusan National University Yangsan Hospital. Recurrence occurred in 13.1% (11/84) of the cases and in-hospital mortality rate was 7.1% (6/84). Stool colonization with vancomycin-resistant enterococci (VRE) (P = 0.006), exposure to more than 3 antibiotics (P = 0.009), low hemoglobin levels (P = 0.025) and continued use of previous antibiotics (P = 0.05) were found to be more frequent in the recurrent group. Multivariate analysis indicated that, ... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5027277 Thu, 30 Jun 2011 23:00:00 +0100 5027277 http://www.medworm.com/index.php?rid=5027276&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21738337%26dopt%3DAbstract Authors: Shin YM, Oh YM, Kim MN, Shim TS, Lim CM, Lee SD, Koh Y, Kim WS, Kim DS, Hong SB It is difficult to differentiate pathogens responsible for pneumonia or colonization in patients with an endotracheal tube or in patients that have undergone tracheostomy. We evaluated the clinical usefulness of quantitative endotracheal aspirates cultures and sought to determine the result threshold level for positivity. The authors performed this retrospective cohort study between December 1, 2004 and January 31, 2006. Forty-five suspected pneumonia patients admitted to an intensive care unit (ICU) with quantitative bronchoalveolar lavage (BAL) and endotracheal aspirate (EA) culture results were enrolled. Using a threshold of 10(5) cfu/mL, 10 of the 45 (22.2%) quantitative EA cultures were positi... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5027276 Thu, 30 Jun 2011 23:00:00 +0100 5027276 http://www.medworm.com/index.php?rid=5027275&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21738338%26dopt%3DAbstract In conclusion, while the 66T>C (rs2251746) of the FcεRIα polymorphism may be linked to AD and higher serum IgE levels, polymorphisms in the FcεRIβ gene did not confer susceptibility to AD in our patient sample. PMID: 21738338 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5027275 Thu, 30 Jun 2011 23:00:00 +0100 5027275 http://www.medworm.com/index.php?rid=5027274&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21738339%26dopt%3DAbstract Authors: Kim DW, Park SA, Kim CG The purpose of this study was to evaluate the value of fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) for detecting the recurrence of gastric cancer. We performed a retrospective review of 139 consecutive patients who underwent PET/CT and contrast-enhanced abdominal CT (CECT) for surveillance of gastric cancer after curative resection. Recurrence of gastric cancer was validated by histopathologic examination for local recurrence or serial imaging study follow-up with at least 1 yr interval for recurrence of distant metastasis form. Twenty-eight patients (20.1%) were confirmed as recurrence. On the patient based analysis, there was no statistically significant difference in the sensitivity, specificity and accuracy of PE... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5027274 Thu, 30 Jun 2011 23:00:00 +0100 5027274 http://www.medworm.com/index.php?rid=5027269&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21738340%26dopt%3DAbstract Authors: Lee SE, Jang JY, Kim MA, Kim SW The purpose of this study was to determine the clinical significance of nodal micrometastasis detected by immunohistochemistry in patients that had undergone curative surgery for pancreatic cancer. Between 2005 and 2006, a total of 208 lymph nodes from 48 consecutive patients with pancreatic cancer that had undergone curative resection were immunostained with monoclonal antibody against pan-ck and CK-19. Micrometastasis was defined as metastasis missed by a routine H&E examination but detected during an immunohistochemical evaluation. Relations between immunohistochemical results and clinical and pathologic features and patient survival were examined. Nodal micrometastases were detected in 5 (29.4%) patients of 17 pN0 patients. Nodal microme... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5027269 Thu, 30 Jun 2011 23:00:00 +0100 5027269 http://www.medworm.com/index.php?rid=5027265&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21738341%26dopt%3DAbstract This study investigated the spectrum of chromosomal abnormalities in 325 leukemia patients and developed optimal profiles of leukemic fusion genes for multiplex RT-PCR. We prospectively analyzed blood and bone marrow specimens of patients with acute leukemia. Twenty types of chromosomal abnormalities were detected in 42% from all patients by commercially available multiplex RT-PCR for detecting 28 fusion genes and in 35% by cytogenetic analysis including FISH analysis. The most common cytogenetic aberrations in acute myeloid leukemia patients was PML/PARA, followed by AML1/MGT8 and MLL1, and in acute lymphoid leukemia patients was BCR/ABL, followed by TEL/AML1 and MLL1 gene rearrangement. Among the negative results for multiplex RT-PCR, clinically significant t(3;3)(q21;q26.2), t(8;14)(q24... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5027265 Thu, 30 Jun 2011 23:00:00 +0100 5027265 http://www.medworm.com/index.php?rid=5027263&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21738342%26dopt%3DAbstract In this study we examined PPs induce redifferentiation in thyroid cancer cell lines. We investigated the effects of genistein, resveratrol, quercetin, kaempferol, and resorcinol on the F9 embryonal carcinoma cell differentiation model. The thyroid cancer cell lines, TPC-1, FTC-133, NPA, FRO, and ARO, displayed growth inhibition in response to genistein, resveratrol, quercetin. We further demonstrated that genistein decreased the dedifferention marker CD97 in NPA cells and resveratrol decreased CD97 in FTC-133, NPA, FRO cells and quercetin decreased CD97 in all cell lines. We observed increased expression of differentiation marker NIS in FTC-133 cells in response to genistein, and resveratrol but no change in NPA, FRO, ARO cells. Quercetin increased or induced NIS in FTC-133, NPA, FRO cells... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5027263 Thu, 30 Jun 2011 23:00:00 +0100 5027263 http://www.medworm.com/index.php?rid=5027262&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21738343%26dopt%3DAbstract Authors: Yoon SE, Ahn SG, Kim JY, Park JS, Shin JH, Tahk SJ, Lee SK, Kim TJ, Han N Whether the metabolic syndrome (MetS) has prognostic value for coronary artery disease (CAD) beyond its individual components is controversial. We compared the relationship between the number of MetS components and CAD severity as assessed by angiography in non-diabetic and diabetic subjects. We consecutively enrolled 527 patients who underwent their first coronary angiography. Patients were divided into four groups according to the number of MetS components: 0/1, 2, 3, and 4/5. A coronary atherosclerosis score was used to quantify the extent of atherosclerotic involvement. The relationship between the MetS score and angiographic CAD severity or clinical presentation was compared between non-diabetic and... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5027262 Thu, 30 Jun 2011 23:00:00 +0100 5027262 http://www.medworm.com/index.php?rid=5027261&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21738344%26dopt%3DAbstract In conclusion, WC has a diagnostic value similar to VFA for predicting MetS in men and postmenopausal women, but not in premenopausal women. Further studies are necessary to develop a simple clinical parameter that reflects visceral fat in premenopausal women. PMID: 21738344 [PubMed - in process] (Source: J Korean Med Sci) J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5027261 Thu, 30 Jun 2011 23:00:00 +0100 5027261 http://www.medworm.com/index.php?rid=5027260&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21738345%26dopt%3DAbstract Authors: Park SB, Blumenthal JA, Lee SY, Georgiades A Obesity and the metabolic syndrome are closely related and have become increasingly prevalent in Korea. The cardiovascular disease (CVD) risk factors comprising the metabolic syndrome have previously been associated with increased hypothalamic-pituitary-adrenal axis (HPAA) activity, but the associations have not been extensively examined in non-Caucasian populations. The aim of the present study was to investigate the relationships between cortisol, adiposity and the metabolic syndrome in a Korean population. A total of 1,881 adults participated in the study between January 2001 and February 2008. Sociodemographic data were assessed by questionnaires. Body composition, clinic blood pressures as well as metabolic variables including ... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5027260 Thu, 30 Jun 2011 23:00:00 +0100 5027260 http://www.medworm.com/index.php?rid=5027259&cid=s_30449_22_f&fid=30449&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21738346%26dopt%3DAbstract In this study, using a partial hepatic ischemic model in vivo, we determined the potential role of CD44 in neutrophil infiltration and liver injury from I/R. Reperfusion caused significant hepatocellular injury as it was determined by plasma ALT levels and liver histopathology. The injury was associated with a marked neutrophil recruitment and CD44 expression into the ischemic livers. Administration of anti-CD44 antibody to mice reduced the infiltration of neutrophil into the ischemic tissue, associated with liver function preservation. These results support crucial roles of CD44 in neutrophil recruitment and infiltration leading to liver damage in hepatic I/R injury. Moreover, they provide the rationale for targeting to CD44 as a potential therapeutic approach in liver I/R injury. PMI... J Korean Med Sci journals http://www.medworm.com/rss/comments.php?id=5027259 Thu, 30 Jun 2011 23:00:00 +0100 5027259