MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'JDDG' source. Sat, 20 Mar 2010 14:05:29 +0100 http://www.medworm.com/index.php?rid=3364599&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2010.07409.x We describe two exceptional collision tumors, namely: a 63-year-old woman revealing a melanocytic tumor within a trichoblastoma and a 71-year-old woman with a squamous cell carcinoma colonized by dendritic cells of a melanoma. Both neoplasms showed two different tumor components with intimate relationship. The lesions are labeled in a "playful" way with the acronyms METRO (MElanocytic tumor +TRichOblastoma) and CAMEL (CArcinoma +MELanoma) to facilitate memorization. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=3364599 Mon, 15 Mar 2010 00:00:00 +0100 3364599 http://www.medworm.com/index.php?rid=3360531&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2010.07391.x We report on a patient, who developed sarcoidal granulomas within the black pigment of his tattoos. This subsequently led to the diagnosis of pulmonary sarcoidosis. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=3360531 Sat, 13 Mar 2010 00:00:00 +0100 3360531 http://www.medworm.com/index.php?rid=3360533&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2010.07345.x Conclusions: Isotretinoin 0.3 mg/kg is an effective and well-tolerated therapy option for the treatment of rosacea subtype II and III and can therefore be used successfully as an alternative to therapy with oral antibiotics. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=3360533 Fri, 12 Mar 2010 00:00:00 +0100 3360533 http://www.medworm.com/index.php?rid=3360532&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2010.07366.x The subcutaneous infiltration of liquid paraffin is still used for penile enlargement. The procedure has many complications. A late problem is the development of foreign body granulomas known as paraffinomnas. They may be necrotic and ulcerated, requiring acute, radical surgical excision. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=3360532 Fri, 12 Mar 2010 00:00:00 +0100 3360532 http://www.medworm.com/index.php?rid=3332672&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2010.07385.x We describe a case of FDE presenting with multiple annular erythematous lesions over dorsal aspects of both feet following the administration of phenobarbital. To the best of our knowledge, such an atypical demonstration had never been reported. Fixed drug eruption should be considered in the differential diagnosis of annular lesions. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=3332672 Fri, 05 Mar 2010 00:00:00 +0100 3332672 http://www.medworm.com/index.php?rid=3308311&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2010.07392.x A 43-year-old healthy patient developed disseminated flat skin-colored to red-brown papules over a few months. These papules were the result of cutaneous IgM deposits representing the first symptom of a hitherto undiagnosed IgM paraproteinemia. This extremely rare skin manifestation of IgM paraproteinemia e. g. possibly incipient Waldenström macroglobulinemia should be included in the histopathological differential of eosinophilic dermal deposits. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=3308311 Fri, 26 Feb 2010 00:00:00 +0100 3308311 http://www.medworm.com/index.php?rid=3308313&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2010.07348.x An adolescent boy presented with isolated, symmetrical, bilateral areolar and periareolar pityriasis versicolor. This extremely rare condition should be considered in the differential diagnosis of light brown patches on the areolae. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=3308313 Thu, 25 Feb 2010 00:00:00 +0100 3308313 http://www.medworm.com/index.php?rid=3308312&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2010.07338.x Conclusions: PRP type I is a severe, chronic inflammatory dermatosis responding hesitantly to classic systemic therapies. Tumor necrosis factor-[alpha] antagonists are an effective treatment option for difficult cases. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=3308312 Thu, 25 Feb 2010 00:00:00 +0100 3308312 http://www.medworm.com/index.php?rid=3303918&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2010.07381.x Conclusions: In comparison to international studies, the prevalence of MRSA in the current study is in the lower third. In dermatology, patients with a chronic leg ulcer have an increased risk for MRSA and should be screened at admission. A general screening for MRSA seems to be not reasonable in view of the low MRSA rates in the investigated department. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=3303918 Thu, 25 Feb 2010 00:00:00 +0100 3303918 http://www.medworm.com/index.php?rid=3285293&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2010.07380.x Conclusions: Knowledge of the polymorphous clinical picture and the complex autoantibody response is essential for an early diagnosis of PNP which has implications for both prognosis and rapid initiation of treatment. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=3285293 Fri, 19 Feb 2010 00:00:00 +0100 3285293 http://www.medworm.com/index.php?rid=3285294&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2010.07319.x Conclusions: The investigated combination therapy was effective and well-tolerated in a subgroup of SS patients but needs to be evaluated in a larger patient population. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=3285294 Thu, 18 Feb 2010 00:00:00 +0100 3285294 http://www.medworm.com/index.php?rid=3273767&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2010.07386.x We report the case of a 65-year old patient with generalised severely itching maculopapular, partly eczematous skin lesions on the buttocks, back, abdomen and arms. The resistance to therapy, several relapses after discharge from hospital as well as the detailed history lead us to the tentative diagnosis. The sofa dermatitis was proven by positive patch testing with furniture material and dimethylfumarate. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=3273767 Tue, 16 Feb 2010 00:00:00 +0100 3273767 http://www.medworm.com/index.php?rid=3273768&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2010.07347.x We present a 48-year-old patient with melanoma of the oral mucosa first diagnosed 22 years ago. Over 20 years several wide excisions were necessary because of multiple local relapses. Eventually, the patient died from brain metastases. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=3273768 Mon, 15 Feb 2010 00:00:00 +0100 3273768 http://www.medworm.com/index.php?rid=3267978&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2010.07358.x Conclusions: Differences in economic and regulatory conditions of health care might account for the observed regional variations. Thus, further analyses of these factors are of great importance to assure consistent psoriasis health care in Germany. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=3267978 Sat, 13 Feb 2010 00:00:00 +0100 3267978 http://www.medworm.com/index.php?rid=3267980&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2010.07355.x A 44-year-old metalworker suffered from severe hand eczema in spite of treatment with corticosteroid ointments. He had been using protective cotton gloves with blue PVC anti-slip dots on the finger tips. On clinical examination, the backs of both hands were erythematous and thickened while the finger tips showed vesicles. There was a positive patch test reaction to the blue PVC dots of an unworn cotton glove at 72, 96, 120 hours. To identify the causative chemicals, we carried out further patch tests using ingredients of the glove and cupric sulfate. The patient reacted to the blue dye VYNAMON® Blue BX FW (PB 15) at two concentrations [ndash] 10% at 72 and 96 hours, and 50% at 48 and 72 hours. This dye is a very strong and brilliant blue with red-copper tones and resistant to fire and wea... JDDG journals http://www.medworm.com/rss/comments.php?id=3267980 Fri, 12 Feb 2010 00:00:00 +0100 3267980 http://www.medworm.com/index.php?rid=3267979&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2010.07327.x Facticious Disorders are self inflicted skin lesions and includes the creation of physical or psychiatric symptoms in oneself or other reference persons. In dermatology frequently, there are mechanical injuries by pressures, friction, occlusion, biting, cutting, stabbing, thermal burns or self-inflicted infections with wound-healing impairment, abscesses, mutilations or damages by acids and other toxic to the skin. The current classification differentiates between four groups: 1. Dermatitis artefacta syndrome in the narrower sense as unconscious/dissociated self-injury, 2. Dermatitis paraartefacta syndrome: Disorders of impulse control, often as manipulation of an existing specific dermatosis (often semi-conscious, admitted [ndash] self-injury), 3. Malingering: consciously simulated injuri... JDDG journals http://www.medworm.com/rss/comments.php?id=3267979 Fri, 12 Feb 2010 00:00:00 +0100 3267979 http://www.medworm.com/index.php?rid=3245208&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2010.07333.x In recent years, in vivo confocal laser scanning microscopy (CLSM) has become an established method for the non-invasive examination of the skin. In vivo CLSM allows for real-time imaging of micro-anatomic cutaneous structures. It has been used to diagnose ambiguous skin tumors and to measure subclinical tumor spread prior to surgery. By additionally providing high power morphologic information, in vivo CLSM helps to reduce unnecessary biopsies. A multitude of diagnostic features for skin tumors has been published. Here we review published diagnostic in vivo CLSM features, and compare them to our own experience in 100 tumors. In combination with clinical examination and dermatoscopy, in vivo CLSM is a valuable additional tool for non-invasive skin tumor diagnosis. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=3245208 Sat, 06 Feb 2010 00:00:00 +0100 3245208 http://www.medworm.com/index.php?rid=3237189&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2010.07346.x The role of histamine as an important proinflammatory mediator has been well known for nearly 100 years. In regards to the immediate type allergic response, there is no debate about the importance of histamine. In addition, histamine has immunomodulatory functions, some of which are related to the histamine H2 receptor. However, with the discovery of the histamine H4 receptor in the year 2000, the role of histamine as an immunomodulator became more obvious. The histamine H4 receptor is expressed on several hematopoietic cells; along with the chemotaxis of immune cells, this recently characterized receptor modulates also the cytokine and chemokine secretion of some hematopoietic cells. Highly selective histamine H4 receptor antagonists display promising results in animal models of allergic ... JDDG journals http://www.medworm.com/rss/comments.php?id=3237189 Thu, 04 Feb 2010 00:00:00 +0100 3237189 http://www.medworm.com/index.php?rid=3237192&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2010.07343.x Photodynamic therapy (PDT) is a modern therapy modality, based upon the application of a photosensitizing agent like aminolevulinic acid, a physiological precursor of porphyrins, onto the tissue followed by illumination with light of the visible wavelength spectrum. During this oxygen-dependent reaction, reactive oxygen species (ROS) are generated that have immunomodulatory or cytotoxic effects. PDT shows excellent cosmetic results especially for its key indication in dermatology [ndash] the treatment of non-melanoma skin cancer. The associated pain and the low tissue penetration are the most frequent limiting factors of PDT. We review basic principles and recent developments in photosensitizers and light sources. Key oncological and non-oncological indications are presented as well. (Sour... JDDG journals http://www.medworm.com/rss/comments.php?id=3237192 Wed, 03 Feb 2010 00:00:00 +0100 3237192 http://www.medworm.com/index.php?rid=3237191&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2010.07316.x Conclusions: The efficacy of camel thorn distillate is comparable to that of other drugs used to treat oral aphthous ulcers. Its therapeutic effect may be due to the flavanones (alhagitin and alhagidin) that are present in this plant. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=3237191 Wed, 03 Feb 2010 00:00:00 +0100 3237191 http://www.medworm.com/index.php?rid=3237190&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2010.07339.x The use of biological response modifiers or biologicals has rapidly expanded since the introduction of the first diagnostic antibodies; they are now widely employed in oncology, autoimmune disorders, inflammatory diseases and transplantation medicine. Their widespread use has resulted in an increase in adverse drug reactions. Adverse effects result from both direct pharmacological actions and immunological actions, as well as through induction of a specific immune response. The nomenclature, particularly of the monoclonal antibodies, identifies the target structure and organ as well as the species of origin, which then helps predict their effects and antigenic properties. Depending on the extent of foreign protein, anti-allotypic or anti-idiotypic antibodies with or without neutralizing pr... JDDG journals http://www.medworm.com/rss/comments.php?id=3237190 Wed, 03 Feb 2010 00:00:00 +0100 3237190 http://www.medworm.com/index.php?rid=3199119&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2010.07261.x Diffuse hair loss is a common complaint and cause of significant emotional distress particularly in women. The best way to alleviate the anxiety is to effectively treat the hair loss. It is paramount to address the symptom systematically. In addition to its psychological impact, hair loss may be a manifestation of a more general medical problem. The diagnosis can be established with a detailed patient history focussing on chronology of events, examination of the scalp and pattern of hair loss, a pull test with examination of bulbs of shed hairs, trichoscopy, and few pertinent screening blood tests. In selected cases a scalp biopsy may be required. The most important differential diagnoses include acute and chronic telogen effluvium, female pattern hair loss, and diffuse alopecia areata. Oc... JDDG journals http://www.medworm.com/rss/comments.php?id=3199119 Sat, 23 Jan 2010 00:00:00 +0100 3199119 http://www.medworm.com/index.php?rid=3109160&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07321.x (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=3109160 Tue, 22 Dec 2009 00:00:00 +0100 3109160 http://www.medworm.com/index.php?rid=3109161&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07337.x According to current statistics of the WHO, tuberculosis is the infectious disease that causes the most deaths worldwide. Its most common cutaneous manifestation is lupus vulgaris which is seldom diagnosed today. A 69-year old immunocompetent woman complained of a partly elevated, partly sclerotic plaque on her left thigh which had been present for more than 55 years before slowly becoming ulcerated. After biopsy and subsequent excision of the 13 cm ulcer, the diagnosis of carcinoma in lupo with lymph node metastasis was made. Cutaneous and additional nodal metastases appeared rapidly. Tuberculostatic therapy was initiated. Despite systemic chemotherapy the tumor subsequently progressed and the patient died of metastatic carcinoma in lupo 15 months after the initial diagnosis. Early diagno... JDDG journals http://www.medworm.com/rss/comments.php?id=3109161 Mon, 21 Dec 2009 00:00:00 +0100 3109161 http://www.medworm.com/index.php?rid=3093786&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07318.x Discussing aesthetic issues and their management with patients is a growing area of dermatologic practice. Sometimes treatment options within one's own discipline are rapidly discussed, without a clear idea of the various aspects of the face which all combine to produce beauty and attractiveness. We review various features leading to the impression of beauty and attractiveness. Familiarity with these concepts should facilitate a broader discussion with the patient on the aspects of beauty and attractiveness beyond the borders of one's own discipline and also lead to multidisciplinary treatment options. We also examine the question how much the personality of the beholder himself is involved in the perception of attractiveness and beauty (of the person sitting opposite to him). The "ideal" ... JDDG journals http://www.medworm.com/rss/comments.php?id=3093786 Thu, 17 Dec 2009 00:00:00 +0100 3093786 http://www.medworm.com/index.php?rid=3083543&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07330.x Conclusions: Lipodystrophy syndrome is an early warning system for a number of illnesses which reduce life expectancy. Dermatologists must help insure that HIV-infected patients receive treatment for these disorders. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=3083543 Mon, 14 Dec 2009 00:00:00 +0100 3083543 http://www.medworm.com/index.php?rid=3083542&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07334.x Psoriatic arthritis (PsA) is an immunologically triggered, chronic inflammatory arthropathy, which can have a lasting influence on the quality of life of affected individuals. An early diagnosis is essential in order to institute adequate therapy. Both dermatologists and rheumatologists should be involved in the diagnosis and management of the disorder. Mild forms can be managed with NSAID and systemic corticosteroids. In acute forms with a confirmed diagnosis and oligo- to polyarticular involvement, disease-modifying therapy with DMARD (Disease-Modifying Antirheumatic Drugs) is indicated. New studies of PsA show that tumor necrosis factor (TNF) plays a central role in mediating inflammation. For this reason, TNF-[alpha] antagonists have become more and more important as a second-line ther... JDDG journals http://www.medworm.com/rss/comments.php?id=3083542 Mon, 14 Dec 2009 00:00:00 +0100 3083542 http://www.medworm.com/index.php?rid=3001322&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07295.x As soon as uveal melanoma has metastasized to the liver, response rates to systemic chemotherapy are low. It can be improved by development of special locoregional procedures. A 24-year-old woman suffered from inoperable hepatic metastases which grew to life-endangering size despite both systemic chemotherapy with gemc-itabine/treosulfan and conventional intrahepatic chemoembolization with fotemustine and starch particles. We subsequently performed two angiographic C-arm CT-guided, superselective chemoembolizations of the hepatic arteries feeding the tumor, using cisplatin, starch microspheres and ethiodized oil. Following this treatment, no vital tumor tissue was detectable by MRI. This remission lasted for more than 6 months and the patient's quality of life was good. A subsequent local ... JDDG journals http://www.medworm.com/rss/comments.php?id=3001322 Wed, 18 Nov 2009 00:00:00 +0100 3001322 http://www.medworm.com/index.php?rid=3001323&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07294.x Leprosy is usually well-controlled by multidrug therapy (MDT). However, in case of noncompliance or leprosy reactions, it may present a therapeutically challenge. A 33-year-old Brazilian woman with lepromatous leprosy was treated with MDT for one year, but then discontinued therapy because she wanted to have children. Eight weeks after stopping her medications, she developed a severe and recalcitrant erythema (nodosum) leprosum (ENL) which presented histologically with thrombosed small veins and neutrophilic inflammation in fat septa, but without arteritis. During her pregnancy and ensuing lactation period, glucocorticoids were the only suitable drug. With the use of the shortened WHO/MDT regimen (one year vs. two years of treatment), ENL will probably be seen more often after the end of l... JDDG journals http://www.medworm.com/rss/comments.php?id=3001323 Tue, 17 Nov 2009 00:00:00 +0100 3001323 http://www.medworm.com/index.php?rid=2986460&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07312.x In February 2009, the European Medicines Agency's (EMEA) Committee for Medicinal Products for Human Use (CHMP) had recommended the suspension of efalizumab's (Raptiva®) marketing authorization, because its benefits in the treatment of psoriasis were modest, while there was a risk of serious side effects in patients receiving the medicine, including the occurrence of progressive multifocal leukoencephalopathy (PML). The guideline group has changed the guideline accordingly. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2986460 Fri, 13 Nov 2009 00:00:00 +0100 2986460 http://www.medworm.com/index.php?rid=2986461&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07290.x Pityriasis rubra pilaris (PRP) is a rare skin disorder with versatile clinical presentations. A 62-year-old Caucasian woman with progressive erythroderma and classic adult (type I) PRP is presented. Treatment with systemic steroids and methotrexate produced no improvement. Clinical remission was achieved after systemic therapy with penicillin (both intravenous and intramuscular) and vitamin A. The therapy of PRP is reviewed, focusing on a possible infectious genesis of PRP as well as the role of antibiotics in its management. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2986461 Thu, 12 Nov 2009 00:00:00 +0100 2986461 http://www.medworm.com/index.php?rid=2951903&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07293.x Conclusions: Treatment was well tolerated and efficient. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2951903 Tue, 03 Nov 2009 00:00:00 +0100 2951903 http://www.medworm.com/index.php?rid=2940948&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07219.x Delusional parasitosis (DP) is the most frequent delusional disorder in dermatology. In DP there is a fixed belief of a usually skin-related invasion or infestation by a number of alleged infectious species (usually parasites and bacteria), whose identity has varied over the decades. Since 2002 worldwide an increasing number of patients have complained of unverifiable fibers and filaments in or on the skin, associated with numerous nonspecific complaints (arthralgias, altered cognitive function and extreme fatigue). This entity has been named "Morgellons disease" by the patients themselves, although medical evidence for its existence is lacking. As an example, we discuss a 55-year-old woman who complained of Morgellons disease and was treated as if she had DP. Currently the delusional assu... JDDG journals http://www.medworm.com/rss/comments.php?id=2940948 Fri, 30 Oct 2009 00:00:00 +0100 2940948 http://www.medworm.com/index.php?rid=2940949&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07313.x The further increase of allergies in industrialized countries demands evidence-based measures of primary prevention. The recommendations as published in the guideline of 2004 were updated and consented on the basis of a systematic literature search. Evidence from the period February 2003[ndash]May 2008 was searched in the electronic databases Cochrane and MEDLINE as well as in reference lists of recent reviews and by contacting experts. The retrieved citations were screened for relevance first by title and abstract and in a second step as full paper. Levels of evidence were assigned to each included study and the methodological quality of the studies was assessed as high or low. Finally the revised recommendations were formally consented (nominal group process) by representatives of releva... JDDG journals http://www.medworm.com/rss/comments.php?id=2940949 Thu, 29 Oct 2009 00:00:00 +0100 2940949 http://www.medworm.com/index.php?rid=2932303&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07292.x Conclusions: The detection of IgA autoantibodies against epidermal transglut-aminase is the most sensitive serological test in the diagnosis of dermatitis herpetiformis. Our observations confirm that patients with dermatitis herpetiformis usually do not demonstrate apparent gastrointestinal symptoms. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2932303 Wed, 28 Oct 2009 00:00:00 +0100 2932303 http://www.medworm.com/index.php?rid=2913742&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07289.x Conclusions: Immediate beginning of therapy is essential for a successful treatment of toxic epidermal necrolysis. Besides systemic therapy with corticosteroids, certain basic measures such as isolation of patients at adequate room temperature to prevent hypothermia, strict control of circulation, temperature and laboratory parameters, daily smears of skin and mucous membranes and a diet rich in calories due to the catabolic metabolic status are very important for successful outcome. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2913742 Wed, 21 Oct 2009 23:00:00 +0100 2913742 http://www.medworm.com/index.php?rid=2887971&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07257.x Cutaneous myiasis is usually a harmless tropical disease caused by infestation with larvae from a variety of flies. Because of its rare occurrence in Europe, it is often misdiagnosed. Increased travel to tropical regions has correspondingly increased the number of cases observed in Europe. The furuncular type of cutaneous myiasis in a 31-year-old biology student was diagnosed upon his return from French Guiana. The student cultured one of the larvae to obtain a botfly. This case is discussed in the light of the current literature on pathogenesis, incidence and therapy of cutaneous myiasis. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2887971 Mon, 12 Oct 2009 23:00:00 +0100 2887971 http://www.medworm.com/index.php?rid=2887970&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07291.x Primary mucinous eccrine carcinoma of the skin is an extremely rare tumor most frequently occurring in the face or capillitium. It is felt to be an eccrine carcinoma, characterized by slow progress and unpredictable locally infiltrative growth. Therefore micrographic surgery is important to avoid local recurrence. It can be difficult to differentiate this carcinoma histologically from cutaneous metastases of breast or gastrointestinal tumors. Because of this, a primary staging in affected patients is essential. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2887970 Mon, 12 Oct 2009 23:00:00 +0100 2887970 http://www.medworm.com/index.php?rid=2884036&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07260.x Conclusions: The association between occupational UV exposure and SCC is well and consistently documented epidemiologically (approximately 2-fold increased risk), so that the criteria for a new occupational disease are fulfilled. The association with BCC is unclear due to significant methodological limitations in the published studies. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2884036 Mon, 12 Oct 2009 23:00:00 +0100 2884036 http://www.medworm.com/index.php?rid=2884035&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07268.x The VEGF signaling pathway (including ligands, surface-bound receptors and intracellular downstream signaling cascades) is critically involved in angiogenesis under normal and pathological conditions, in particular in malignant tumors. As a consequence, several therapies that target specific components of this pathway have been approved for clinical use or are in various stages of clinical development. Currently, the monoclonal antibodies bevacizumab and ranibizumab, as well as the small-molecule kinase inhibitors sorafenib and sunitinib, have been approved for cancer therapy. The spectrum of cutaneous side effects elicited by bevacizumab is considerably less pronounced than that seen with EGF inhibitors and includes peripheral sensory neuropathy, stomatitis, skin dryness, skin discolorati... JDDG journals http://www.medworm.com/rss/comments.php?id=2884035 Mon, 12 Oct 2009 23:00:00 +0100 2884035 http://www.medworm.com/index.php?rid=2881719&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07259.x (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2881719 Sun, 11 Oct 2009 23:00:00 +0100 2881719 http://www.medworm.com/index.php?rid=2873457&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07218.x Conclusions: Micrographically-controlled surgery followed by plastic reconstruction is the treatment of choice for non-melanoma skin tumors of the head and neck area. Cosmetic results are excellent. Minor procedures can be performed by residents during their training; larger defects require more experience in dermatosurgery. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2873457 Thu, 08 Oct 2009 23:00:00 +0100 2873457 http://www.medworm.com/index.php?rid=2873456&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07271.x We describe the treatment of two patients who received hyaluronic acid products produced by Q-Med (Macrolane[trade] VRF20, Restylane® Vital and Vital Light). The injections of Macrolane[trade] VRF 20 were done by feathering technique using a long and blunt 18 gauge canula while Restylane® was injected by tunneling or tenting technique with a 30 gauge needle. Significant adverse events did not occur. After injection of the hyaluronic acid fillers, the appearance of the back of the hands was improved. Both patients were very satisfied with the result. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2873456 Thu, 08 Oct 2009 23:00:00 +0100 2873456 http://www.medworm.com/index.php?rid=2873455&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07275.x The S3 (evidence-based) psoriasis guidelines were an important milestone in German dermatology. Three years after their publication, a review and evaluation of their success is important. Since the publication of the guidelines, the quality of care of psoriasis patients has improved. The proportion of patients with a PASI above 20 in the general patient population has decreased, there are less days of work lost due to psoriasis, uncertainties in administering systemic therapies have been decreased and the proportion of patients with severe psoriasis receiving a systemic treatment has increased. The guidelines' website as well as the original publication in the JDDG has been accessed more than 50,000 times. The guidelines' discussion was continued even after its publication and in further p... JDDG journals http://www.medworm.com/rss/comments.php?id=2873455 Thu, 08 Oct 2009 23:00:00 +0100 2873455 http://www.medworm.com/index.php?rid=2833157&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07266.x Hemangiomas are the most common vascular tumors in children. They occur in 8[ndash]12% of all infants and in 22% of premature infants (female: male = 3: 1). Hemangiomas are usually sporadic; their etiology is unknown [1]. A premature female infant, born at 28 weeks of gestation, presented with a large hemangioma of the right thoracic wall. Within the first few weeks, the hemangioma showed rapid horizontal and vertical growth as well as ulceration, which led us to initiate systemic therapy. The effectiveness of propranolol (non-selective ß-blocker) in the management of severe cases of hemangioma has been shown in a recent series of cases [2]. We began oral propranolol treatment, in close interdisciplinary cooperation. After a few days of therapy, the tumor had stopped expanding. After 18 w... JDDG journals http://www.medworm.com/rss/comments.php?id=2833157 Fri, 25 Sep 2009 23:00:00 +0100 2833157 http://www.medworm.com/index.php?rid=2833158&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07254.x We report two patients with microcystic adnexal carcinoma, using them as a basis to discuss, pathogenesis, diagnosis, histology and therapy of the tumor. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2833158 Thu, 24 Sep 2009 23:00:00 +0100 2833158 http://www.medworm.com/index.php?rid=2829623&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07137.x Skin color is highly individual and the variations are controlled by numerous genes. The different skin colors result from the size and number of melanosomes and do not mirror the amount of melanocytes. Disorders of pigmentation can result from migration abnormalities of melanocytes from the neural crest to the skin during embryogenesis. In addition, impairment of melanosome transfer to the surrounding keratinocytes, an alteration in melanin synthesis and a defective degradation or removal of melanin may lead to abnormal skin pigmentation. Immunologic or toxic mediated destructions of melanocytes can end in pigmentation disorders. Disorders of pigmentation are classified in hypo- or hyperpigmentation which can occur as a genetic or acquired disease. They can manifest locally or diffuse. Co... JDDG journals http://www.medworm.com/rss/comments.php?id=2829623 Thu, 24 Sep 2009 23:00:00 +0100 2829623 http://www.medworm.com/index.php?rid=2798198&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07215.x The bradykinin B2 receptor antagonist icatibant has recently become available for treating hereditary angioedema. Our observations demonstrate icatibant to be effective and safe for the treatment of both, abdominal and cutaneous attacks in a practice setting beyond clinical studies. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2798198 Tue, 15 Sep 2009 23:00:00 +0100 2798198 http://www.medworm.com/index.php?rid=2794370&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07216.x We examined the causes of periorbital dermatitis and compared the data of 88 patients from the Department of Dermatology, University Hospital Erlangen to those of the German IVDK (Information Network of the Departments of Dermatology). Between 1999 and 2004, predominant causes of periorbital dermatitis were allergic contact dermatitis (Erlangen 44 %, IVDK 32 %), atopic eczema (Erlangen 25 %, IVDK 14 %), airborne contact dermatitis (Erlangen 10 %, IVDK 2 %) and irritant contact dermatitis (Erlangen 9 %, IVDK 8 %). Less frequent causes for secondary eczematous periocular skin lesions were periorbital rosacea, allergic conjunctivitis or psoriasis vulgaris. Female gender, atopic skin diathesis and age of 40 years and older were identified as risk factors for periocular dermatitis. Common elici... JDDG journals http://www.medworm.com/rss/comments.php?id=2794370 Mon, 14 Sep 2009 23:00:00 +0100 2794370 http://www.medworm.com/index.php?rid=2794374&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07210.x Conclusions: A scientific society in general acts in a permanent area of conflict and has to deal with multiple positions and interests.Thereby members' needs and demands may vary dependent on individual and professional backgrounds. Members who are not scientifically active should be more integrated in the society while at the same time the society's aims should be coordinated with that of the Berufsverband (organization of practicing dermatologists). Better networking is required both within the society and with outside groups. In addition, the primary aims and objectives of the society should be made even clearer to all interested parties. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2794374 Sun, 13 Sep 2009 23:00:00 +0100 2794374 http://www.medworm.com/index.php?rid=2794373&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07212.x Conclusions: It is possible to run ECP in low-body weight patients with the UVAR® XTS[trade] system. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2794373 Sun, 13 Sep 2009 23:00:00 +0100 2794373 http://www.medworm.com/index.php?rid=2794372&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07217.x A major function of human skin is to form an effective barrier between the environment and the inside of the organism. Especially important for this function is the activity of the physical barrier of the skin, which is mainly located in the stratum corneum. To improve this barrier function of the skin, skin protection agents are used. Recent studies have revealed that application of skin protection agents before exposition to xenobiotics does not generally reduce the percutaneous uptake of these compounds. These findings indicate that besides new study designs and improved test systems, there seems to be a need for new therapeutic approaches for more effective skin protection. In this light, new findings regarding a second barrier function of the human skin, the biochemical/toxicological ... JDDG journals http://www.medworm.com/rss/comments.php?id=2794372 Sun, 13 Sep 2009 23:00:00 +0100 2794372 http://www.medworm.com/index.php?rid=2794371&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07125.x Allergic reactions to Hymenoptera stings usually present as large local reactions or systemic reactions with symptoms of immediate type allergy (anaphylaxis). In Central Europe they are predominantly elicited by stings of the honeybee or Vespula spp. Acute reactions are managed by symptomatic treatment. Long-term care includes patient education (allergen avoidance, course of action at re-sting) and prescription of an emergency kit for self-treatment. Venom immunotherapy is established as specific treatment for Hymenoptera venom allergic patients. Diagnosis of Hymenoptera venom anaphylaxis is based on history, skin tests and measurement of venom-specific serum IgE antibodies. "False negative" or "false positive" results are possible with all test methods. If standard tests are negative, add... JDDG journals http://www.medworm.com/rss/comments.php?id=2794371 Sun, 13 Sep 2009 23:00:00 +0100 2794371 http://www.medworm.com/index.php?rid=2783433&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07213.x Conclusions: Topical cannabinoid receptor agonists are an effective and well-tolerated adjuvant therapy option in postherpetic neuralgia. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2783433 Thu, 10 Sep 2009 23:00:00 +0100 2783433 http://www.medworm.com/index.php?rid=2748926&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07202.x The present review highlights the evolution of the skin-associated immune system from the invertebrates to the vertebrates and man. In the invertebrates a non-specific humoral immune response dominates. It includes antimicrobial peptides, oxidases, lysozyme, agglutinins, coagulins and melanin. The cellular immune system initially consists of undifferentiated mesenchymal stem cells. Later migrating phagocytes and natural killer cells occur. From the fishes on, dendritic cells are present, linking innate and adaptive immune responses. In addition to this unspecific but highly effective immune system, the specific immune response, based on genetic recombination, is present in the vertebrates starting with the chondral fishes. The adaptive immune system possesses unlimited numbers of highly sp... JDDG journals http://www.medworm.com/rss/comments.php?id=2748926 Mon, 31 Aug 2009 23:00:00 +0100 2748926 http://www.medworm.com/index.php?rid=2748925&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07214.x A patient with painful erosions of the oral cavity and the labia minora developed multifocal blisters in inter-triginous areas. These blisters eroded and evolved into papillomatous erosive vegetations. Histopathology and immunopathological investigations confirmed the diagnosis of pemphigus vegetans, mediated by IgG autoantibodies. The circulating IgG1 and IgG4 autoantibodies were exclusively directed against desmoglein 3, as shown by ELISA and indirect immunofluorescence studies. These IgG1 and IgG4 isotypes were also in vivo bound, as demonstrated with immunoperoxidase staining of perilesional skin. Our clinical, biochemical and immunopathological observations confirm the hypothesis that pemphigus vegetans is a variant of pemphigus vulgaris. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2748925 Mon, 31 Aug 2009 23:00:00 +0100 2748925 http://www.medworm.com/index.php?rid=2748924&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07250.x (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2748924 Mon, 31 Aug 2009 23:00:00 +0100 2748924 http://www.medworm.com/index.php?rid=2713897&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07209.x We present a patient treated with surgery, immunomodulatory therapy, and polychemotherapy. He then received hematopoietic stem cell transplantation and has been in complete remission since. Allogeneic stem cell transplantation appears to be a promising therapeutic option for aggressive and generally fatal lymphomas like GD-TCL. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2713897 Wed, 19 Aug 2009 23:00:00 +0100 2713897 http://www.medworm.com/index.php?rid=2710388&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07154.x We report for the first time the successful combination of infliximab and MTX for the treatment of PRP. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2710388 Tue, 18 Aug 2009 23:00:00 +0100 2710388 http://www.medworm.com/index.php?rid=2700890&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07157.x The skin's permeability barrier protects against extensive water loss and prevents the entry into the skin of harmful substances like irritants, allergens and microorganisms. The permeability barrier is mainly located in the stratum corneum and consists of corneocytes and a lipid-enriched intercellular domain. The barrier is formed during epidermal differentiation. In atopic dermatitis the skin barrier is disturbed already in non-lesional skin. The disturbed skin barrier allows the entry of environmental allergens from house dust mites, animal dander and grass pollen into the skin. In predisposed individuals these allergens may trigger via immunologic pathways the inflammation of atopy. The causes for the disturbed epidermal skin barrier are changes in skin lipids and in epidermal differen... JDDG journals http://www.medworm.com/rss/comments.php?id=2700890 Fri, 14 Aug 2009 23:00:00 +0100 2700890 http://www.medworm.com/index.php?rid=2689680&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07211.x The post-thrombotic syndrome (PTS) is a common but not completely understood and rarely studied sequela of an acute deep vein thrombosis. The influence of several risk factors on the incidence or severity of PTS is controversial. The therapeutic options for PTS are still limited. Appropriate medical compression stockings can reduce the incidence ([ndash]50 %) as well as the severity of PTS. In the case of severe, symptomatic PTS, they should be worn lifelong. As PTS is a chronic and often progressive disease, patients need regular clinical follow-up and encouragement to continuously wear their compression therapy. New strategies for treating PTS are needed. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2689680 Tue, 11 Aug 2009 23:00:00 +0100 2689680 http://www.medworm.com/index.php?rid=2663222&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07153.x We report a case of folliculotropic mycosis fungoides developing in the months following methotrexate therapy in a psoriatic patient. This lymphoma did not regress after stopping the antipsoriatic treatment. There is a known relationship between the use of immunosuppressive therapies and the development of lymphoproliferative malignancies. However these lymphomas are mainly B-cell non-Hodgkin lymphomas associated with Epstein-Barr virus. In our patient the short period of time from the beginning of the immunosuppressive treatment to the occurrence of the T-cell lymphoma does not support a strong causal relationship between the drug intake and the development of mycosis fungoides. To the best of our knowledge, this is the first case of folliculotropic mycosis fungoides in a patient treated ... JDDG journals http://www.medworm.com/rss/comments.php?id=2663222 Sun, 02 Aug 2009 23:00:00 +0100 2663222 http://www.medworm.com/index.php?rid=2635677&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07156.x We describe a family, in which we performed a molecular-genetic examination and found a new mutation in exon 19 in the CYLD gene leading to a frameshift. It is important to be aware of this syndrome and its pathogenesis as its phenotypic features can vary so that apparently different diseases are caused by the same genetic defect. In addition, there may be malignant transformation of the generally benign tumors, so that a timely diagnosis is essential for appropriate monitoring and therapy. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2635677 Fri, 24 Jul 2009 23:00:00 +0100 2635677 http://www.medworm.com/index.php?rid=2635681&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07119.x (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2635681 Thu, 23 Jul 2009 23:00:00 +0100 2635681 http://www.medworm.com/index.php?rid=2635680&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07121.x The worldwide incidence of skin cancer (especially non-melanoma skin cancer) has risen dramatically over the last decades. Skin cancer, including pre-malignant lesions, is becoming a chronic disease. Adjustments in skin cancer health care need to be made. A disease management system for skin cancer is mandatory in order to avoid waiting lists and insure adequate treatment quality with ever growing numbers of patients requiring treatment. At the Catharina Hospital Eindhoven adjustments are being made on several levels of the dermato-oncology unit in collaboration with Eindhoven University of Technology. The model combines technological improvements, training health care workers, training of general practitioners and prevention of skin cancer. We discuss our ideas and clinical experiences wi... JDDG journals http://www.medworm.com/rss/comments.php?id=2635680 Thu, 23 Jul 2009 23:00:00 +0100 2635680 http://www.medworm.com/index.php?rid=2635679&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07138.x We present female twins with reticular erythematous mucinosis (REM syndrome). Remarkably, the lesions developed in both sisters almost at the same time in the same locations after UV exposure. Reports of familial manifestations of REM syndrome are very rare and an association to a distinct HLA constellation has not been proven. Our report clearly suggests a genetic predisposition. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2635679 Thu, 23 Jul 2009 23:00:00 +0100 2635679 http://www.medworm.com/index.php?rid=2635678&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07141.x Pimecrolimus has been approved for more than five years for the treatment of atopic dermatitis in Germany. An important difference in the safety profile of this drug compared with topical corticosteroids is the lack of potential side effects which are often observed upon prolonged use of topical corticosteroids (skin atrophy, steroid-induced rosacea or perioral dermatitis). Even after prolonged use in sensitive skin areas, no tolerance to this drug is induced, in contrast to that seen with topical corticosteroids. The most common side effect of pimecrolimus is burning. Placebo-controlled studies suggest that pimecrolimus is associated with a slightly increased incidence of herpes simplex infections. Compared with topical corticosteroids, pimecrolimus does not increase the overall incidence... JDDG journals http://www.medworm.com/rss/comments.php?id=2635678 Thu, 23 Jul 2009 23:00:00 +0100 2635678 http://www.medworm.com/index.php?rid=2631773&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07098.x Antiretroviral therapy has improved continuously. Almost every year a new drug has been approved. Nucleoside analogs still build the backbone of antiretroviral therapy. They inhibit reverse transcriptase and thus the transcription of RNA to DNA. They are combined with non-nucleoside reverse transcriptase inhibitors or protease inhibitors. New therapeutic approaches are attachment or entry inhibitors, integrase inhibitors and maturation inhibitors. Multiple prospective multicenter studies have proven the life prolonging effect of antiretroviral therapy. With the optimal therapy life expectancy of HIV patients is only slightly reduced, similar to that of those with chronic diseases such as diabetes mellitus. One result of the higher age of HIV patients is an increase in concomitant diseases ... JDDG journals http://www.medworm.com/rss/comments.php?id=2631773 Thu, 23 Jul 2009 23:00:00 +0100 2631773 http://www.medworm.com/index.php?rid=2623238&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07124.x We report on a 30-year-old man working as an industrial mechanic from 1995 to 2006. After approval of an occupational disease no. 5101 of the German ordinance on industrial disease in 2007, he went to court claiming compensation. The sensitization with clinical and occupational relevance to potassium dichromate that was decisive for the evaluation for insurance purposes was first confirmed in a patch test in 2005. Succeeding tests in 2006 in the context of an expert opinion and in 2008 in the context of our decisive expert opinion remained negative. We could reconfirm the potassium dichromate sensitization only by the SPT performed in the proposed standardized manner. The potassium dichromate allergy was the determining factor in the assessment for insurance purposes. This resulted in an a... JDDG journals http://www.medworm.com/rss/comments.php?id=2623238 Tue, 21 Jul 2009 23:00:00 +0100 2623238 http://www.medworm.com/index.php?rid=2614776&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07180.x Extramammary Paget disease (EMPD) is a rare neoplasm that arises in skin rich in apocrine glands, such as the axillae and anogenital region and usually affects the elderly. In most cases, EMPD is an apocrine carcinoma in situ, but it can be associated with internal malignancy spreading to overlying skin. Surgical excision with margin control is the generally accepted standard of care. A 74-year-old woman presented with a 1 year history of a pruritic eczematous eruption in perineum which on biopsy was diagnosed as EMPD. Because of the location and extent of the tumor, any surgical approach would have been problematic. Imiquimod 5% cream applied three times weekly for 16 weeks induced complete resolution. Topical imiquimod appears to be a promising treatment option for EMPD, especially when ... JDDG journals http://www.medworm.com/rss/comments.php?id=2614776 Sat, 18 Jul 2009 23:00:00 +0100 2614776 http://www.medworm.com/index.php?rid=2607546&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07118.x (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2607546 Thu, 16 Jul 2009 23:00:00 +0100 2607546 http://www.medworm.com/index.php?rid=2607547&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07100.x Conclusions: After the introduction of the German "Praxisgebühr" fewer patients with AE received dermatological treatment. Simultaneously, an unexpectedly significant increase in the (non evidence-based) treatment of AE with systemic steroids was observed, of which patients with relatively lower consultation frequency after the introduction of the co-payment were particularly affected. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2607547 Wed, 15 Jul 2009 23:00:00 +0100 2607547 http://www.medworm.com/index.php?rid=2599549&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07159.x We report on an 8-year-old girl with tricho-dento-osseous syndrome, who presented in our allergy center with severe atopic dermatitis. Additional clinical findings included light, kinky hair reminiscent of pili trianguli et canaliculi (uncombable hair), enamel hypoplasia and enlarged pulp chambers of the molar teeth (tau-rodontism). A genetic investigation revealed a de-novo mutation in the DLX3 gene on chromosome 17q21. Electron microscopic examination of the curly hair showed a flattened hair shaft with longitudinal grooves. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2599549 Tue, 14 Jul 2009 23:00:00 +0100 2599549 http://www.medworm.com/index.php?rid=2557734&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07155.x Conclusions: Acne vulgaris is a burdensome, socio-economically relevant illness, and dermatologists treat most cases in Germany. Surveying across a network of pharmacies offers a unique access to relevant treatment data. Selection effects, particularly by choice of doctors and self-medication, were minimized. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2557734 Tue, 30 Jun 2009 23:00:00 +0100 2557734 http://www.medworm.com/index.php?rid=2479370&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07102.x Cutaneous metastases from gastric cancer are uncommon with a frequency of 7 % but can rarely be the presenting sign. A 54-year-old man complained of multiple pea-sized scalp nodules which had been present for four months. Histology showed a metastatic adenocarcinoma. Initial evaluation revealed liver metastases and gastroscopy then identified a tumor involving the distal esophagus and gastric cardia that was diagnosed as a gastric tubular carcinoma. The patient had a good response to polychemotherapy. While gastric carcinoma generally metastasizes to the abdominal wall or lymph nodes, our patient showed an exceptional variant with distant cutaneous metastases as the first clinical sign. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2479370 Tue, 16 Jun 2009 04:00:00 +0100 2479370 http://www.medworm.com/index.php?rid=2479369&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07103.x We report the first case of a multiple clustered dermatofibroma with overlying sebaceous hyperplasia. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2479369 Tue, 16 Jun 2009 04:00:00 +0100 2479369 http://www.medworm.com/index.php?rid=2476366&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07140.x In Germany there is limited information available about the distribution of the tropical rat mite (Ornithonyssus bacoti) in rodents. A few case reports show that this hematophagous mite species may also cause dermatitis in man. Having close body contact to small rodents is an important question for patients with pruritic dermatoses. The definitive diagnosis of this ectopara-sitosis requires the detection of the parasite, which is more likely to be found in the environment of its host (in the cages, in the litter or in corners or cracks of the living area) than on the hosts' skin itself. A case of infestation with tropical rat mites in a family is reported here. Three mice that had been removed from the home two months before were the reservoir. The mites were detected in a room where the c... JDDG journals http://www.medworm.com/rss/comments.php?id=2476366 Mon, 15 Jun 2009 04:00:00 +0100 2476366 http://www.medworm.com/index.php?rid=2476367&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07099.x Podoconiosis or mossy foot is a form of non-filarial lymphedema. This geo-chemical elephantiasis is a disabling condition caused by the passage of microparticles of silica and aluminum silicates through the skin of people walking barefoot in areas with a high content of soil of volcanic origin. Podoconiosis is widespread in tropical Africa, Central America and North India, yet it remains a neglected and under-researched condition. The disabling effects of podoco-niosis cause great hardship to patients. It adversely affects the economic (reduced productivity and absenteeism), social (marriage, education, etc.) and psychological (social stigma) well-being of those affected. Podoconiosis can be prevented; the main primary preventive measure is protective footwear. Secondary measures include a... JDDG journals http://www.medworm.com/rss/comments.php?id=2476367 Thu, 28 May 2009 04:00:00 +0100 2476367 http://www.medworm.com/index.php?rid=2476368&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07101.x Conclusions: PGE1-EE could be a promising drug formulation in local penile therapy of ED. In further studies higher doses should be investigated in order to potentially achieve a higher level of efficacy. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2476368 Thu, 14 May 2009 04:00:00 +0100 2476368 http://www.medworm.com/index.php?rid=2476369&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07120.x Conclusions: In the long-term treatment of patients with moderate and severe psoriasis FAE show a good and sustained clinical efficacy combined with a favorable safety profile. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2476369 Mon, 04 May 2009 04:00:00 +0100 2476369 http://www.medworm.com/index.php?rid=2476371&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07097.x Basal cell carcinoma is the most common tumor in Central Europe, the U.S. and Australia. The increasing incidence of basal cell carcinoma presents the health care system, especially dermatology, with great challenges. In recent years new options for treating basal cell carcinoma have become available, enriching our therapeutic options. We review the current status of each of these treatment approaches. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2476371 Fri, 24 Apr 2009 04:00:00 +0100 2476371 http://www.medworm.com/index.php?rid=2476370&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07095.x A 58-year-old man presented in 2001 with dysplastic nevus syndrome with at least 300 nevi and about 100 clinically highly atypical nevi. Three melanomas had been excised by a private dermatologist within the past year. We then removed two additional melanomas. Between 2002 and 2003, 117 nevi which were atypical on dermatoscopy were removed; most by horizontal (shave) excision. Adequate clinical and dermatoscopic control was not feasible due to the large number of atypical nevi. In order to reduce the number of nevus cells, we treated test sites with both dermabrasion and split-thickness excision. The latter proved to be more efficient and was used to completely excise the skin of the back, as well as parts of the arms and chest in two sessions under general anesthesia. Wound healing was un... JDDG journals http://www.medworm.com/rss/comments.php?id=2476370 Fri, 24 Apr 2009 04:00:00 +0100 2476370 http://www.medworm.com/index.php?rid=2476374&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07096.x A 52-year-old geriatric nurse presented with recurrent eczema localized in uncovered skin areas. Patch testing produced an eczematous skin reaction with type IV sensitization to tetrazepam. A relapse of contact dermatitis was successfully prevented by using occupational skin protection measures and organizational measures. Our case indicates that a sensitization to drugs should be considered when allergic contact dermatitis is suspected in nursing personnel. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2476374 Tue, 21 Apr 2009 04:00:00 +0100 2476374 http://www.medworm.com/index.php?rid=2476372&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07093.x Modern acne therapy uses anticomedogenic, antimicrobial, antiinflammatory, and antiandrogenic substances. As an additional approach in recent years, treatments have been developed based on the application of electromagnetic radiation. Visible light or infrared wave lengths are utilized by most techniques, including blue light lamps, intense pulsed light, photodynamic therapy and lasers. This review evaluates the various methods with regard to efficacy and their current role in the management of acne. Although UV radiation has been frequently used to treat acne, it is now regarded as obsolete due to the unfavorable risk-benefit ratio. Visible light, especially of blue wavelengths, appears to be suitable for the treatment of mild to moderate inflammatory acne. Photodynamic therapy is effecti... JDDG journals http://www.medworm.com/rss/comments.php?id=2476372 Tue, 21 Apr 2009 04:00:00 +0100 2476372 http://www.medworm.com/index.php?rid=2476379&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07037.x Inflammatory non-infectious diseases of the nails are not uncommon. The nail changes may look different in the same diseases, but also very much alike in various different nail disorders depending on which particular structure of the nail apparatus is involved. Of all skin diseases, psoriasis is the one with the most frequent nail involvement. The presence of many pits allows the diagnosis to be made, but salmon spots and onycholysis are also characteristic features. Lichen planus may occur isolated on the nails or in association with lesions of the skin and adjacent mucosal membranes. Longitudinal striations and loss of the nail plate shine are the most frequent features of nail lichen planus. The more severe the alopecia areata is and the younger the patient is, the more often it affects... JDDG journals http://www.medworm.com/rss/comments.php?id=2476379 Mon, 06 Apr 2009 04:00:00 +0100 2476379 http://www.medworm.com/index.php?rid=2476378&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07056.x A ten-year-old boy presented with recurrent eczema on the dorsa of both feet and the thighs. His symptoms became worse when he used racing swim fins. Patch testing included the standard, ointments, preservatives, leather, textile dyes, rubber component, and corticosteroid series of the German Contact Dermatitis Research Group (DKG) as well as the patient's own materials (fin material). At 72 hours positive reactions were observed to blue flipper material, Acid Yellow 36, Bismarck Brown R, and DPPD. DPPD is widely used as an anti-oxidant in the rubber industries. Therefore, the dermatitis was most probably attributable to DPPD in the blue flipper material, although we were not able to prove this due to lack of cooperation of the manufacturer. Sensitization to Acid Yellow 36 and Bismarck Bro... JDDG journals http://www.medworm.com/rss/comments.php?id=2476378 Mon, 06 Apr 2009 04:00:00 +0100 2476378 http://www.medworm.com/index.php?rid=2476377&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07082.x Conclusion: Even though ulcer healing is an admirable goal, it does not necessarily lead to an improved QOL, probably because of the numerous comorbidi-ties in this patient group. Nonetheless, it is important to control problems associated directly with the wound to allow ulcer patients to participate actively in everyday life and minimize social problems. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2476377 Mon, 06 Apr 2009 04:00:00 +0100 2476377 http://www.medworm.com/index.php?rid=2476376&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07084.x Off-label use is defined as the usage of pharmaceuticals beyond their submitted, tested and approved use. Not only indications but also doses, route of administration, patients' characteristics and concomitant therapies are affected by the approval. In recent years, the impact of off-label use has increased markedly primarily because of the large number of new medications with often limited approval. In dermatology, a multitude of diagnoses exist which are so uncommon that they have no chance of approval studies. Experiences of off-label use often provide important scientific data that can influence or even improve further concepts of therapy. Both professional liability and mode of payment are still controversial for medications in off-label use. There is an urgent need for more legal cer... JDDG journals http://www.medworm.com/rss/comments.php?id=2476376 Mon, 06 Apr 2009 04:00:00 +0100 2476376 http://www.medworm.com/index.php?rid=2476375&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07094.x (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2476375 Mon, 06 Apr 2009 04:00:00 +0100 2476375 http://www.medworm.com/index.php?rid=2476373&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07032.x Scientific progress in pathophysiology and differentiation of pain, functional diagnostic of pain and emerging treatments highlight this subject. Basics of development of pain, as well as differentiation of nociceptive and neuropathic pain are depicted; the latter is illustrated with the example of postherpetic neuralgia. Complex regional pain syndromes are described as a third pain complex. Principles of differentiated pain management are given. Substance groups from the WHO scheme including antipyretic analgesics, non-steroidal antiinflammatory drugs (NSAIDs) and opioids are discussed. Recommendations of the Drug Commission of the German Medical Association concerning NSAIDs and of the International Association for the Study of Pain (IASP) concerning new treatment options for cancer pain... JDDG journals http://www.medworm.com/rss/comments.php?id=2476373 Mon, 06 Apr 2009 04:00:00 +0100 2476373 http://www.medworm.com/index.php?rid=2476381&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07058.x Hereditary palmoplantar keratodermas (PPK) comprise a clinically and genetically heterogeneous group of genodermatoses, which share impaired epidermal differentiation resulting in prominent palmoplantar hyperkeratosis. Classically, keratodermas have been separated according to their clinical appearance into diffuse, focal, and as a feature of ectodermal dysplasias and many other syndromes. Since molecular genetic analyses have helped characterize the underlying genetic defects in an increasing number of hereditary PPK over the last two decades, a pathophysiological separation seems more reasonable. Today PPK can be classified based on defects in keratins, loricrin, desmosomes, connexins, and cathepsins. Although these proteins have different structures and functions, all of them influence ... JDDG journals http://www.medworm.com/rss/comments.php?id=2476381 Wed, 01 Apr 2009 04:00:00 +0100 2476381 http://www.medworm.com/index.php?rid=2476380&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07083.x Psoriasis has seen a dramatic change in its perception by dermatologists as well as other medical specialties. Its well-recognized association with several other diseases makes a complete switch in its management necessary. This review summarizes current epidemiological data on the comorbidities of psoriasis. Subsequently, the evidence for insulin resistance as a cause for endothelial cell dysfunction with its relevant pathogenetic link to the development of cardiovascular comorbidity is discussed. Based on these novel insights, we propose a possible state-of-the-art approach towards comprehensive psoriasis management. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2476380 Wed, 01 Apr 2009 04:00:00 +0100 2476380 http://www.medworm.com/index.php?rid=2476382&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07057.x Digital ulcers in progressive systemic sclerosis (PSS) are often refractory to therapy. A frequently chronic aggressive course can lead to the loss of acral limbs involved. A 73-year-old woman developed a dramatic worsening of her ulcerations despite maximum conventional therapy. Switching therapy to bosentan and sildenafil, both in low-dose regimens, resulted for the first time in ten years in a complete healing of the ulcers. If substantiated in a series of patients, the additive and perhaps synergistic clinical benefits of combining bosentan and sildenafil may be a valuable option for the treatment of acral ulcers in PSS. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2476382 Thu, 19 Mar 2009 04:00:00 +0100 2476382 http://www.medworm.com/index.php?rid=2476384&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07028.x We describe legal aspects of compassionate use are discussed, taking two of our cases as examples. Finally, examples for necessary documents to apply for compassionate use are provided. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2476384 Tue, 03 Mar 2009 05:00:00 +0100 2476384 http://www.medworm.com/index.php?rid=2476383&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07033.x A genetic mosaic is defined as an organism which is composed of genetically different cell lines which originate from a homogeneous zygote. Etiologically, cutaneous mosaics can be divided into two large categories, epigenetic mosaicism and genomic mosaicism. Genomic mosaics which have two or more genetically different cell populations are not inherited with the exception of paradominant inheritance pattern. Epigenetic mosaics have a structurally homogeneous cell population but there are functional differences induced by modifying factors in the form of gene-steering retroviral elements that can be inherited. We distinguish five different manifestation patterns of mosaicism, including the Blaschko lines pattern, patchy pattern without midline separation, checkerboard pattern, phylloid patte... JDDG journals http://www.medworm.com/rss/comments.php?id=2476383 Tue, 03 Mar 2009 05:00:00 +0100 2476383 http://www.medworm.com/index.php?rid=2476385&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07039.x Conclusion: Knowledge of the many commercial and non-commercial pre- and intra-operative skin labeling systems and their advantages and disadvantages helps to reduce the use of relatively expensive commercial skin markers. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2476385 Fri, 27 Feb 2009 05:00:00 +0100 2476385 http://www.medworm.com/index.php?rid=2476387&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07030.x Conclusion: Our study shows that an interactive computer simulation program of mycological KOH preparation results in a significant learning effectiveness as far as recall of the correct procedural steps is concerned. Furthermore, subjective acceptance by students is high. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2476387 Thu, 26 Feb 2009 05:00:00 +0100 2476387 http://www.medworm.com/index.php?rid=2476386&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07055.x An infection with Bartonella henselae transmitted from domestic cats to humans by scratching normally leads to cat-scratch disease. When the human host has severe immunosuppression or HIV infection, the potentially life-threatening disease bacillary angiomatosis can develop. A 79-year-old man presented with livid-erythematous, angioma-like skin lesions. We considered a cutaneous infiltrate from his known chronic lymphocytic leukemia, Merkel cell carcinoma, cutaneous metastases of internal tumors, cutaneous sarcoidosis, mycobacterial infection and even atypical herpes simplex infection. The correct diagnosis was proven histologically and by PCR. Because of increasing numbers of immunosuppressed and HIV-positive patients, as well as an infection rate of 13 % for B. henselae in domestic cats ... JDDG journals http://www.medworm.com/rss/comments.php?id=2476386 Thu, 26 Feb 2009 05:00:00 +0100 2476386 http://www.medworm.com/index.php?rid=2476390&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07029.x Conclusions: German dermatology reflects the international trend showing reductions of length of stay after introduction of a DRG-based hospital funding system. The DRG calculation and valuation of inpatient services depend on the duration of hospital stay. However, increasing per diem costs resulting from higher performances of every inpatient bed day are also taken into account. Further reduction of length of stay must not threaten the quality of inpatient care in dermatology. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2476390 Tue, 24 Feb 2009 05:00:00 +0100 2476390 http://www.medworm.com/index.php?rid=2476389&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07044.x We present the unusual case of an 83-year-old woman who appeared to have facial photoallergic contact dermatitis but turned out to have facial Sweet syndrome. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2476389 Tue, 24 Feb 2009 05:00:00 +0100 2476389 http://www.medworm.com/index.php?rid=2476388&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07045.x We present eight children [ndash] all of them with dry skin [ndash] who developed perioral dermatitis after using sunscreens based on micropigments. This suggests that children with dry skin are at increased risk for perioral dermatitis. A history of sunscreen use should be specifically sought in children with perioral dermatitis. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2476388 Tue, 24 Feb 2009 05:00:00 +0100 2476388 http://www.medworm.com/index.php?rid=2476392&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07034.x Conclusions: The QoL of patients with keloids and HTS is impaired as much as that of those with psoriasis. The DLQI questionnaire is a reliable and valid instrument for assessing the QoL in patients with keloids and HTS. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2476392 Fri, 20 Feb 2009 05:00:00 +0100 2476392 http://www.medworm.com/index.php?rid=2476391&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07043.x Subcorneal pustulosis (Sneddon-Wilkinson disease) is a rare inflammatory neutrophilic dermatosis. While subcorneal pustulosis is often associated with an IgA gammopathy, the combined lack of IgG/IgM seen in our case is rare. An 83-year-old man with combined lack of IgG/IgM and monoclonal gammopathy type IgA/Kappa presented with subcorneal pustules. Intravenous immunoglobulin therapy led to complete regression and might be another therapeutic option. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2476391 Fri, 20 Feb 2009 05:00:00 +0100 2476391 http://www.medworm.com/index.php?rid=2476394&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07035.x Conclusions: In this cohort, more than three percent of the treated patients developed a contact dermatitis to the antiseptic. However, the differentiation between allergic and irritant contact dermatitis towards the ingredients of the antiseptic remains problematic. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2476394 Wed, 18 Feb 2009 05:00:00 +0100 2476394 http://www.medworm.com/index.php?rid=2476393&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07042.x A 24-year-old man was admitted for a painful gingival ulcer. Histology and immunohistochemistry of a lesional biopsy revealed the diagnosis of Langerhans cell histiocytosis (LCH). To rule out multifocal disease, a complete staging was performed. There was no evidence of bony lesions or any other organ involvement. The diagnosis of LCH restricted to the oral mucosa was established. The complete oral lesion was ablated by CO2 laser and subsequently treated topically with triamcinolone acetonide. The patient is still in remission after one year of follow-up. LCH confined to the oral mucosa is rare. It presents usually as an inflammatory or ulcerative lesion, easily leading to misinterpretation and delayed diagnosis. Patients with limited unifocal mucocutaneous disease, as in the present case,... JDDG journals http://www.medworm.com/rss/comments.php?id=2476393 Wed, 18 Feb 2009 05:00:00 +0100 2476393 http://www.medworm.com/index.php?rid=2476396&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07036.x We present an adult woman with SFMS who was followed by multiple specialties since birth without the correct diagnosis being made. She was referred to us with the diagnosis of multiple basal cell carcinomas of head and face. Our diagnosis of systematized nevus sebaceus was crucial for the correct classification of SFMS. We identified multiple trichoblastomas in the nevi sebacei and could exclude basal cell carcinomas. The essential clue was the detection of multiple Merkel cells within the epidermal layer by cytokeratin 20 staining. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2476396 Mon, 02 Feb 2009 05:00:00 +0100 2476396 http://www.medworm.com/index.php?rid=2476395&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07040.x A woman with oculocutaneous Behçet disease developed primary tuberculosis while being treated with infliximab. A latent tuberculosis infection had been excluded before therapy. After more than 80 weeks of treatment, the patient complained of fevers, night sweats, shivering and vigorous cough. The chest x-ray showed miliary shadowing. Mycobacterium tuberculosis was identified. The history revealed recent contact to an individual with smear-positive tuberculosis. This constellation speaks in favor of a de novo tuberculosis infection with a fulminant course. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2476395 Mon, 02 Feb 2009 05:00:00 +0100 2476395 http://www.medworm.com/index.php?rid=2476397&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2009.07027.x Although dermoscopy has been primarily designed for aiding the in vivo diagnosis of skin tumors, recent advances indicate it is also useful in the diagnosis of common skin infections and infestations. As such, dermoscopy connects the research fields of dermatology and entomology into one field of "entomodermoscopy". In this article we give an overview on the current applications of entomodermoscopy. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=2476397 Sat, 31 Jan 2009 05:00:00 +0100 2476397 http://www.medworm.com/index.php?rid=2476398&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1610-0387.2008.06970.x Congenital ichthyoses are a group of genetic disorders with defective cornification, clinically characterized by scaling of the skin. Additionally, distinctive cutaneous inflammation can often be observed. For most of the patients these diseases lead to a significant restriction in quality of life. The diagnostic hallmarks are discussed. The diagnostic criteria include clinical and histological findings, often enhanced or confirmed by specialized tests. Because many of the congenital ichthyoses are extremely rare, their accurate diagnosis is often carried out in specialized centers. After discussing the vulgar ichthyoses as well as the diagnostic and therapeutic options in part one, in this second part we review congenital ichthyoses both with and without associated symptoms, focusing on t... JDDG journals http://www.medworm.com/rss/comments.php?id=2476398 Thu, 15 Jan 2009 05:00:00 +0100 2476398 http://www.medworm.com/index.php?rid=1533472&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2008.06765.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 6, Issue s2, Page S10-S14, July 2008. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1533472 Fri, 20 Jun 2008 13:55:56 +0100 1533472 http://www.medworm.com/index.php?rid=1533471&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2008.06764.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 6, Issue s2, Page S4-S9, July 2008. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1533471 Fri, 20 Jun 2008 13:55:56 +0100 1533471 http://www.medworm.com/index.php?rid=1533470&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2008.06763.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 6, Issue s2, Page S1-S3, July 2008. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1533470 Fri, 20 Jun 2008 13:55:56 +0100 1533470 http://www.medworm.com/index.php?rid=1533475&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2008.06794.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 6, Issue s2, Page S24-S27, July 2008. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1533475 Fri, 20 Jun 2008 13:55:55 +0100 1533475 http://www.medworm.com/index.php?rid=1533474&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2008.06767.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 6, Issue s2, Page S17-S23, July 2008. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1533474 Fri, 20 Jun 2008 13:55:55 +0100 1533474 http://www.medworm.com/index.php?rid=1533473&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2008.06766.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 6, Issue s2, Page S15-S16, July 2008. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1533473 Fri, 20 Jun 2008 13:55:55 +0100 1533473 http://www.medworm.com/index.php?rid=1529147&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2008.06780.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Summary Treatment of sun-damaged skin and wrinkles is attracting increasing interest as the possible approaches expand. Recently mono- und bipolar radiofrequency devices have been introduced as new treatment options for skin rejuvenation. Initial studies ... (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1529147 Wed, 18 Jun 2008 18:14:52 +0100 1529147 http://www.medworm.com/index.php?rid=1529148&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2008.06806.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Summary Systemic lupus erythematosus and subacute cutaneous lupus erythematosus (SCLE) occasionally evolve as adverse reactions to a large variety of chemically different drugs. We here report on a 76-year-old woman who developed SCLE within 10 days ... (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1529148 Wed, 18 Jun 2008 02:22:07 +0100 1529148 http://www.medworm.com/index.php?rid=1529149&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2008.06785.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Summary Psoriasis is a common, chronic inflammatory and frequently severe skin disease. Recent epidemiologic studies have documented an increased cardio-vascular mortality in psoriasis patients. Our own work focuses on endothelial cells as mediators for ... (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1529149 Wed, 18 Jun 2008 02:19:00 +0100 1529149 http://www.medworm.com/index.php?rid=1515119&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2008.06753.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Summary Though most dermatoses are not life-threatening, skin diseases play an important role in intensive care medicine. Skin findings in intensive care patients may reflect the underlying disease or be complications of intensive medical care. Most ... (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1515119 Fri, 13 Jun 2008 18:13:55 +0100 1515119 http://www.medworm.com/index.php?rid=1498506&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2007.06754.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Summary Background: Immunophenotyping is essential for diagnostics of cutaneous lymphomas. In this regard we present a skin tissue-adapted application platform of MELC technology. Patients and Methods: This topoproteome analysis allows the subcellular ... (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1498506 Fri, 06 Jun 2008 18:14:36 +0100 1498506 http://www.medworm.com/index.php?rid=1479150&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2008.06786.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Summary Increasing evidence suggests that cancer is a disease in which the persistence of the tumor relies on a small population of tumor-initiating cells, the so called tumor stem cells (TSC). Only these cells are capable of self-renewal and thereby ... (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1479150 Fri, 30 May 2008 18:16:15 +0100 1479150 http://www.medworm.com/index.php?rid=1479151&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2007.06603_supp.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 6, Issue 6, Page -, June 2008. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1479151 Fri, 30 May 2008 07:45:04 +0100 1479151 http://www.medworm.com/index.php?rid=1459836&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2008.06779.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Summary  A two-year-old girl presented with a 20 month history of a facial nodule which had appeared after a vacation on Mallorca. Various topical treatments at other hospitals for the working diagnosis of mastocytoma failed to prevent a slow increase in ... (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1459836 Wed, 21 May 2008 18:20:32 +0100 1459836 http://www.medworm.com/index.php?rid=1459838&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2008.06769.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Summary  Two patients with metastatic malignant melanoma developed immediate type hypersensitivity-like symptoms while being treated with recombinant interleukin-(IL-)2 immunotherapy. Both patients showed positive skin prick tests to IL-2, enhanced ... (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1459838 Wed, 21 May 2008 12:32:30 +0100 1459838 http://www.medworm.com/index.php?rid=1459837&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2008.06735.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Summary  In a patient with foreign-body granulomas, dog hairs were identified as the causative agent by combing history, histopathology and highly sensitive detection of species-specific canine mitochondrial DNA. Granulomas from human hair are well known ... (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1459837 Wed, 21 May 2008 12:32:30 +0100 1459837 http://www.medworm.com/index.php?rid=1459839&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2008.06742.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Summary  Lymphogranuloma venereum (LGV) is a venereal disease caused by Chlamydia trachomatis biovars L1 to L3. Unlike other anogenital C. trachomatis infections, LGV preferably affects lymphatic tissue after invasion through an epithelial surface. LGV ... (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1459839 Wed, 21 May 2008 12:32:29 +0100 1459839 http://www.medworm.com/index.php?rid=1459840&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2008.06736.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Summary  Herpes simplex vegetans is a rare disorder even in immunocompromised patients. It typically affects patients with HIV or myeloproliferative diseases.The atypical cutaneous lesions show papillomatous vegetations in varying locations. ... (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1459840 Wed, 21 May 2008 12:32:28 +0100 1459840 http://www.medworm.com/index.php?rid=1456726&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2008.06773.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 6, Issue 6, Page 441, June 2008. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1456726 Tue, 20 May 2008 07:48:54 +0100 1456726 http://www.medworm.com/index.php?rid=1456744&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2008.06580.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 6, Issue 6, Page 515-518, June 2008. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1456744 Tue, 20 May 2008 07:48:53 +0100 1456744 http://www.medworm.com/index.php?rid=1456735&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2008.06758.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 6, Issue 6, Page 483-491, June 2008. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1456735 Tue, 20 May 2008 07:48:13 +0100 1456735 http://www.medworm.com/index.php?rid=1456742&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2008.06411.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 6, Issue 6, Page 510-513, June 2008. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1456742 Tue, 20 May 2008 07:48:10 +0100 1456742 http://www.medworm.com/index.php?rid=1456743&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2008.06723.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 6, Issue 6, Page 514-515, June 2008. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1456743 Tue, 20 May 2008 07:48:06 +0100 1456743 http://www.medworm.com/index.php?rid=1456738&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2008.06503.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 6, Issue 6, Page 503-504, June 2008. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1456738 Tue, 20 May 2008 07:48:02 +0100 1456738 http://www.medworm.com/index.php?rid=1456739&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2008.06759.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 6, Issue 6, Page 505-506, June 2008. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1456739 Tue, 20 May 2008 07:47:00 +0100 1456739 http://www.medworm.com/index.php?rid=1456746&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2008.06724.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 6, Issue 6, Page 523, June 2008. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1456746 Tue, 20 May 2008 07:46:58 +0100 1456746 http://www.medworm.com/index.php?rid=1456740&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2008.06634.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 6, Issue 6, Page 508-509, June 2008. Summary This Macro-Micro-Dermatology-contribution with the theme innovative drugs and drug reactions illustrates two new observations of practical interest: 1. Follicular eruption after Everolimus and 2. Atrophy of sebaceous glands after Sirolimus. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1456740 Tue, 20 May 2008 07:46:54 +0100 1456740 http://www.medworm.com/index.php?rid=1456731&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2007.06458_supp.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 6, Issue 6, Page -, June 2008. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1456731 Tue, 20 May 2008 07:46:47 +0100 1456731 http://www.medworm.com/index.php?rid=1456737&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2008.06675_supp.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 6, Issue 6, Page -, June 2008. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1456737 Tue, 20 May 2008 07:46:41 +0100 1456737 http://www.medworm.com/index.php?rid=1456728&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2008.06591_supp.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 6, Issue 6, Page -, June 2008. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1456728 Tue, 20 May 2008 07:46:39 +0100 1456728 http://www.medworm.com/index.php?rid=1456732&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2007.06497_supp.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 6, Issue 6, Page -, June 2008. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1456732 Tue, 20 May 2008 07:46:24 +0100 1456732 http://www.medworm.com/index.php?rid=1456733&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2008.06603.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 6, Issue 6, Page 480-482, June 2008. Summary Steatocystoma multiplex is a rare, almost exclusively autosomal dominant disease of the sebaceous glands. The sites of predilection are the sternal region, upper back, axillae and proximal parts of the extremities. A 78-year-old woman developed ... (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1456733 Tue, 20 May 2008 07:46:22 +0100 1456733 http://www.medworm.com/index.php?rid=1456741&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2008.06734_supp.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 6, Issue 6, Page -, June 2008. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1456741 Tue, 20 May 2008 07:46:21 +0100 1456741 http://www.medworm.com/index.php?rid=1456745&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2008.06774.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 6, Issue 6, Page 519-522, June 2008. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1456745 Tue, 20 May 2008 07:46:20 +0100 1456745 http://www.medworm.com/index.php?rid=1456729&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2007.06609_supp.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 6, Issue 6, Page -, June 2008. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1456729 Tue, 20 May 2008 07:46:20 +0100 1456729 http://www.medworm.com/index.php?rid=1456751&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2008.06761.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 6, Issue 6, Page 526-528, June 2008. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1456751 Tue, 20 May 2008 07:46:19 +0100 1456751 http://www.medworm.com/index.php?rid=1456730&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2008.06738_supp.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 6, Issue 6, Page -, June 2008. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1456730 Tue, 20 May 2008 07:46:19 +0100 1456730 http://www.medworm.com/index.php?rid=1456734&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2008.06603_supp.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 6, Issue 6, Page -, June 2008. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1456734 Tue, 20 May 2008 07:46:18 +0100 1456734 http://www.medworm.com/index.php?rid=1456747&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2008.06775.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 6, Issue 6, Page 523, June 2008. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1456747 Tue, 20 May 2008 07:46:17 +0100 1456747 http://www.medworm.com/index.php?rid=1456736&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2008.06675.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 6, Issue 6, Page 492-499, June 2008. Summary Follow-up, rehabilitation and palliative/supportive care are essential parts of the care and treatment of skin cancer patients. This review provides an overview on the state of knowledge and recent developments in these three disciplines, hereby ... (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1456736 Tue, 20 May 2008 07:46:17 +0100 1456736 http://www.medworm.com/index.php?rid=1456750&cid=s_31728_12_f&fid=31728&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1610-0387.2008.06760.x%3Fai%3D111%26mi%3D4mpuw%26af%3DR JDDG, Volume 6, Issue 6, Page 525, June 2008. (Source: JDDG) JDDG journals http://www.medworm.com/rss/comments.php?id=1456750 Tue, 20 May 2008 07:46:16 +0100 1456750