MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'JNCI' source. Wed, 08 Feb 2012 08:41:37 +0100 http://www.medworm.com/index.php?rid=5666675&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F3%2F255%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5666675 Tue, 07 Feb 2012 05:00:00 +0100 5666675 http://www.medworm.com/index.php?rid=5666674&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F3%2F254-a%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5666674 Tue, 07 Feb 2012 05:00:00 +0100 5666674 http://www.medworm.com/index.php?rid=5666673&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F3%2F254%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5666673 Tue, 07 Feb 2012 05:00:00 +0100 5666673 http://www.medworm.com/index.php?rid=5666672&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F3%2F240%3Frss%3D1 Conclusion Overall, these results provide strong evidence that EBV status is an etiologically important classification of cHL and also suggest that some components of the pathological process are common to both EBV-positive and EBV-negative patients. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5666672 Tue, 07 Feb 2012 05:00:00 +0100 5666672 http://www.medworm.com/index.php?rid=5666671&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F3%2F228%3Frss%3D1 Conclusions Not all mutant KRas proteins affect patient survival or downstream signaling in a similar way. The heterogeneous behavior of mutant KRas proteins implies that therapeutic interventions may need to take into account the specific mutant KRas expressed by the tumor. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5666671 Tue, 07 Feb 2012 05:00:00 +0100 5666671 http://www.medworm.com/index.php?rid=5666670&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F3%2F211%3Frss%3D1 Conclusion The addition of oxaliplatin to 5-FU appears to be associated with better survival among patients receiving adjuvant colon cancer treatment in the community. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5666670 Tue, 07 Feb 2012 05:00:00 +0100 5666670 http://www.medworm.com/index.php?rid=5666669&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F3%2F189%3Frss%3D1 Conclusion Monoclonal antibodies against HERV-K env protein show potential as novel immunotherapeutic agents for breast cancer therapy. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5666669 Tue, 07 Feb 2012 05:00:00 +0100 5666669 http://www.medworm.com/index.php?rid=5666668&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F3%2F178%3Frss%3D1 Conclusions The sensitivity of Self-HPV testing compared favorably with that of LBC and was superior to the sensitivity of VIA. Self-HPV testing may complement current screening programs by increasing population coverage in settings that do not have easy access to comprehensive cytology-based screening. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5666668 Tue, 07 Feb 2012 05:00:00 +0100 5666668 http://www.medworm.com/index.php?rid=5666667&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F3%2F177%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5666667 Tue, 07 Feb 2012 05:00:00 +0100 5666667 http://www.medworm.com/index.php?rid=5666666&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F3%2F176%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5666666 Tue, 07 Feb 2012 05:00:00 +0100 5666666 http://www.medworm.com/index.php?rid=5666665&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F3%2F174%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5666665 Tue, 07 Feb 2012 05:00:00 +0100 5666665 http://www.medworm.com/index.php?rid=5666664&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F3%2F172%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5666664 Tue, 07 Feb 2012 05:00:00 +0100 5666664 http://www.medworm.com/index.php?rid=5666663&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F3%2F170%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5666663 Tue, 07 Feb 2012 05:00:00 +0100 5666663 http://www.medworm.com/index.php?rid=5666662&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F3%2F169%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5666662 Tue, 07 Feb 2012 05:00:00 +0100 5666662 http://www.medworm.com/index.php?rid=5666661&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F3%2F168%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5666661 Tue, 07 Feb 2012 05:00:00 +0100 5666661 http://www.medworm.com/index.php?rid=5666660&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F3%2F166%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5666660 Tue, 07 Feb 2012 05:00:00 +0100 5666660 http://www.medworm.com/index.php?rid=5666659&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F3%2F165%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5666659 Tue, 07 Feb 2012 05:00:00 +0100 5666659 http://www.medworm.com/index.php?rid=5666658&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F3%2FNP-e%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5666658 Tue, 07 Feb 2012 05:00:00 +0100 5666658 http://www.medworm.com/index.php?rid=5666657&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F3%2FNP-d%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5666657 Tue, 07 Feb 2012 05:00:00 +0100 5666657 http://www.medworm.com/index.php?rid=5666656&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F3%2FNP-c%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5666656 Tue, 07 Feb 2012 05:00:00 +0100 5666656 http://www.medworm.com/index.php?rid=5666655&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F3%2FNP-b%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5666655 Tue, 07 Feb 2012 05:00:00 +0100 5666655 http://www.medworm.com/index.php?rid=5666654&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F3%2FNP-a%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5666654 Tue, 07 Feb 2012 05:00:00 +0100 5666654 http://www.medworm.com/index.php?rid=5666653&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F3%2FNP%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5666653 Tue, 07 Feb 2012 05:00:00 +0100 5666653 http://www.medworm.com/index.php?rid=5607981&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F2%2F163-a%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5607981 Tue, 17 Jan 2012 05:00:00 +0100 5607981 http://www.medworm.com/index.php?rid=5607980&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F2%2F163%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5607980 Tue, 17 Jan 2012 05:00:00 +0100 5607980 http://www.medworm.com/index.php?rid=5607979&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F2%2F159%3Frss%3D1 The 2007 American Society of Clinical Oncology and College of American Pathologists (ASCO/CAP) joint guidelines defined criteria for HER2 positivity of tumors that modified those of the US Food and Drug Administration (FDA), causing some confusion and uncertainty among clinicians. Using data from the HER2-positive breast cancer adjuvant trial N9831, we compared eligibility for patients who met both criteria, and disease-free survival (DFS) was assessed by Cox proportional hazards regression. The number of patients in the N9831 trial retrospectively eligible for trastuzumab therapy was decreased when ASCO/CAP criteria vs FDA criteria were applied to immunohistochemistry and/or fluorescence in situ hybridization results (107 [3.7%] of 2904 patients with immunohistochemistry results, 37 [1.3%... JNCI journals http://www.medworm.com/rss/comments.php?id=5607979 Tue, 17 Jan 2012 05:00:00 +0100 5607979 http://www.medworm.com/index.php?rid=5607978&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F2%2F147%3Frss%3D1 Conclusions We found limited serological evidence of an association between esophageal squamous cell carcinoma and HPV in the populations studied. Although HPV does not appear to be an important risk factor for esophageal squamous cell carcinoma, we cannot exclude the possibility that certain HPV types may be involved in a small subset of cancers. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5607978 Tue, 17 Jan 2012 05:00:00 +0100 5607978 http://www.medworm.com/index.php?rid=5607977&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F2%2F133%3Frss%3D1 Conclusion YB-1 expression is associated with the activity of E2F transcription factors and may control tumor cell growth by this mechanism. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5607977 Tue, 17 Jan 2012 05:00:00 +0100 5607977 http://www.medworm.com/index.php?rid=5607976&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F2%2F125%3Frss%3D1 Conclusions After 13 years of follow-up, there was no evidence of a mortality benefit for organized annual screening in the PLCO trial compared with opportunistic screening, which forms part of usual care, and there was no apparent interaction with age, baseline comorbidity, or pretrial PSA testing. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5607976 Tue, 17 Jan 2012 05:00:00 +0100 5607976 http://www.medworm.com/index.php?rid=5607975&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F2%2F114%3Frss%3D1 Conclusions Previous estimates of index performance have been overly optimistic because they did not take into account the time required to make a diagnosis on the basis of testing in response to symptoms. In addition, the specificity of a symptom index is lower when based on a telephone interview vs questionnaire or GP notes. Thus, the clinical utility of a symptom index depends on precisely how it is used and how index-positive women are managed. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5607975 Tue, 17 Jan 2012 05:00:00 +0100 5607975 http://www.medworm.com/index.php?rid=5607974&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F2%2F93%3Frss%3D1 With the advent of targeted agents for the treatment of renal cell carcinoma (RCC), overall survival has improved, and patients are being treated continuously for increasingly long periods of time. This has raised challenges in the management of adverse events (AEs) associated with the six targeted agents approved in RCC—sorafenib, sunitinib, pazopanib, bevacizumab (in combination with interferon alpha), temsirolimus, and everolimus. Suggestions for monitoring and managing AEs have been published, but there are few consensus recommendations. In addition, there is a risk that patients will be subjected to multiple unnecessary investigations. In this review, we aimed to identify the level of supporting evidence for suggested AE management strategies to provide practical guidance on ess... JNCI journals http://www.medworm.com/rss/comments.php?id=5607974 Tue, 17 Jan 2012 05:00:00 +0100 5607974 http://www.medworm.com/index.php?rid=5607973&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F2%2F90%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5607973 Tue, 17 Jan 2012 05:00:00 +0100 5607973 http://www.medworm.com/index.php?rid=5607972&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F2%2F88%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5607972 Tue, 17 Jan 2012 05:00:00 +0100 5607972 http://www.medworm.com/index.php?rid=5607971&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F2%2F87%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5607971 Tue, 17 Jan 2012 05:00:00 +0100 5607971 http://www.medworm.com/index.php?rid=5607970&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F2%2F86%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5607970 Tue, 17 Jan 2012 05:00:00 +0100 5607970 http://www.medworm.com/index.php?rid=5607969&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F2%2F84%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5607969 Tue, 17 Jan 2012 05:00:00 +0100 5607969 http://www.medworm.com/index.php?rid=5607968&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F2%2F82%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5607968 Tue, 17 Jan 2012 05:00:00 +0100 5607968 http://www.medworm.com/index.php?rid=5607967&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F2%2F81%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5607967 Tue, 17 Jan 2012 05:00:00 +0100 5607967 http://www.medworm.com/index.php?rid=5607966&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F2%2FNP-e%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5607966 Tue, 17 Jan 2012 05:00:00 +0100 5607966 http://www.medworm.com/index.php?rid=5607965&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F2%2FNP-d%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5607965 Tue, 17 Jan 2012 05:00:00 +0100 5607965 http://www.medworm.com/index.php?rid=5607964&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F2%2FNP-c%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5607964 Tue, 17 Jan 2012 05:00:00 +0100 5607964 http://www.medworm.com/index.php?rid=5607963&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F2%2FNP-b%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5607963 Tue, 17 Jan 2012 05:00:00 +0100 5607963 http://www.medworm.com/index.php?rid=5607962&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F2%2FNP-a%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5607962 Tue, 17 Jan 2012 05:00:00 +0100 5607962 http://www.medworm.com/index.php?rid=5607961&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F2%2FNP%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5607961 Tue, 17 Jan 2012 05:00:00 +0100 5607961 http://www.medworm.com/index.php?rid=5559386&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F1%2F79%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5559386 Tue, 03 Jan 2012 05:00:00 +0100 5559386 http://www.medworm.com/index.php?rid=5559385&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F1%2F78%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5559385 Tue, 03 Jan 2012 05:00:00 +0100 5559385 http://www.medworm.com/index.php?rid=5559384&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F1%2F77-a%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5559384 Tue, 03 Jan 2012 05:00:00 +0100 5559384 http://www.medworm.com/index.php?rid=5559382&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F1%2F67%3Frss%3D1 Conclusion This study suggests that greater consumption of isoflavone-containing foods is associated with a reduced risk of endometrial cancer in this population of nonhysterectomized postmenopausal women. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5559382 Tue, 03 Jan 2012 05:00:00 +0100 5559382 http://www.medworm.com/index.php?rid=5559381&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F1%2F56%3Frss%3D1 Conclusions There is substantial uncertainty regarding the cost-effectiveness of Oncotype DX–directed chemotherapy. It is particularly important that future research studies to inform cost-effectiveness–based decisions collect long-term outcome data. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5559381 Tue, 03 Jan 2012 05:00:00 +0100 5559381 http://www.medworm.com/index.php?rid=5559380&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F1%2F42%3Frss%3D1 Conclusions The combination of G47 and TMZ acts synergistically in killing GSCs through oHSV-mediated manipulation of DNA damage responses. This strategy is highly efficacious in representative preclinical models and warrants clinical translation. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5559380 Tue, 03 Jan 2012 05:00:00 +0100 5559380 http://www.medworm.com/index.php?rid=5559379&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F1%2F29%3Frss%3D1 Conclusions APBIb after breast-conserving surgery has been rapidly adopted in the United States. Use varied by race, ethnicity, and widely by region, especially among patients who may not be suitable for this radiation technique. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5559379 Tue, 03 Jan 2012 05:00:00 +0100 5559379 http://www.medworm.com/index.php?rid=5559378&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F1%2F18%3Frss%3D1 Conclusions Available evidence suggests that high-dose therapy and ASCT as part of FL initial treatment does not improve overall survival. Future trials of ASCT in the context of current chemoimmunotherapy approaches to FL are needed. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5559378 Tue, 03 Jan 2012 05:00:00 +0100 5559378 http://www.medworm.com/index.php?rid=5559377&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F1%2F16%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5559377 Tue, 03 Jan 2012 05:00:00 +0100 5559377 http://www.medworm.com/index.php?rid=5559376&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F1%2F14%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5559376 Tue, 03 Jan 2012 05:00:00 +0100 5559376 http://www.medworm.com/index.php?rid=5559375&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F1%2F13%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5559375 Tue, 03 Jan 2012 05:00:00 +0100 5559375 http://www.medworm.com/index.php?rid=5559374&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F1%2F12%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5559374 Tue, 03 Jan 2012 05:00:00 +0100 5559374 http://www.medworm.com/index.php?rid=5559373&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F1%2F10%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5559373 Tue, 03 Jan 2012 05:00:00 +0100 5559373 http://www.medworm.com/index.php?rid=5559372&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F1%2F8%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5559372 Tue, 03 Jan 2012 05:00:00 +0100 5559372 http://www.medworm.com/index.php?rid=5559371&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F1%2F5%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5559371 Tue, 03 Jan 2012 05:00:00 +0100 5559371 http://www.medworm.com/index.php?rid=5559370&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F1%2F3%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5559370 Tue, 03 Jan 2012 05:00:00 +0100 5559370 http://www.medworm.com/index.php?rid=5559369&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F1%2F1%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5559369 Tue, 03 Jan 2012 05:00:00 +0100 5559369 http://www.medworm.com/index.php?rid=5559368&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F1%2FNP-e%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5559368 Tue, 03 Jan 2012 05:00:00 +0100 5559368 http://www.medworm.com/index.php?rid=5559367&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F1%2FNP-d%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5559367 Tue, 03 Jan 2012 05:00:00 +0100 5559367 http://www.medworm.com/index.php?rid=5559366&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F1%2FNP-c%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5559366 Tue, 03 Jan 2012 05:00:00 +0100 5559366 http://www.medworm.com/index.php?rid=5559365&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F1%2FNP-b%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5559365 Tue, 03 Jan 2012 05:00:00 +0100 5559365 http://www.medworm.com/index.php?rid=5559364&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F1%2FNP-a%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5559364 Tue, 03 Jan 2012 05:00:00 +0100 5559364 http://www.medworm.com/index.php?rid=5559363&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F104%2F1%2FNP%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5559363 Tue, 03 Jan 2012 05:00:00 +0100 5559363 http://www.medworm.com/index.php?rid=5524006&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F24%2F1904%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5524006 Tue, 20 Dec 2011 05:00:00 +0100 5524006 http://www.medworm.com/index.php?rid=5524005&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F24%2F1903-b%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5524005 Tue, 20 Dec 2011 05:00:00 +0100 5524005 http://www.medworm.com/index.php?rid=5524004&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F24%2F1903-a%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5524004 Tue, 20 Dec 2011 05:00:00 +0100 5524004 http://www.medworm.com/index.php?rid=5524003&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F24%2F1903%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5524003 Tue, 20 Dec 2011 05:00:00 +0100 5524003 http://www.medworm.com/index.php?rid=5524002&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F24%2F1901%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5524002 Tue, 20 Dec 2011 05:00:00 +0100 5524002 http://www.medworm.com/index.php?rid=5524001&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F24%2F1899%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5524001 Tue, 20 Dec 2011 05:00:00 +0100 5524001 http://www.medworm.com/index.php?rid=5524000&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F24%2F1884%3Frss%3D1 Conclusion IL-15 directs the epithelial differentiation of renal CSCs and meets the criteria for a treatment strategy: CSC pool depletion and generation of differentiated nontumorigenic cells that are sensitive to chemotherapeutic agents. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5524000 Tue, 20 Dec 2011 05:00:00 +0100 5524000 http://www.medworm.com/index.php?rid=5523999&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F24%2F1871%3Frss%3D1 Conclusions Sample preservation in RNAlater improves RNA yield and quality, whereas cold ischemia increases RNA fragmentation as measured by the 3'/5' expression ratio of control genes. However, expression levels of single genes and multigene signatures that are of diagnostic relevance in breast cancer were mostly unaffected by sample preservation method or prolonged cold ischemic duration. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5523999 Tue, 20 Dec 2011 05:00:00 +0100 5523999 http://www.medworm.com/index.php?rid=5523998&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F24%2F1859%3Frss%3D1 Conclusions The malignancy-risk gene signature was associated with OS and was a prognostic and predictive indicator. The malignancy-risk gene signature could be useful to improve prediction of OS and to identify those NSCLC patients who will benefit from ACT. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5523998 Tue, 20 Dec 2011 05:00:00 +0100 5523998 http://www.medworm.com/index.php?rid=5523997&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F24%2F1851%3Frss%3D1 Conclusion Patients provide a subjective measure of symptom severity that complements clinician scoring in predicting overall survival. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5523997 Tue, 20 Dec 2011 05:00:00 +0100 5523997 http://www.medworm.com/index.php?rid=5523996&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F24%2F1840%3Frss%3D1 Conclusion Folate intake was not associated with overall risk of pancreatic cancer in this large pooled analysis. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5523996 Tue, 20 Dec 2011 05:00:00 +0100 5523996 http://www.medworm.com/index.php?rid=5523995&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F24%2F1827%3Frss%3D1 Information on the causes of cancer at specific sites is important to cancer control planners, cancer researchers, cancer patients, and the general public. The International Agency for Research on Cancer (IARC) Monograph series, which has classified human carcinogens for more than 40 years, recently completed a review to provide up-to-date information on the cancer sites associated with more than 100 carcinogenic agents. Based on IARC’s review, we listed the cancer sites associated with each agent and then rearranged this information to list the known and suspected causes of cancer at each site. We also summarized the rationale for classifications that were based on mechanistic data. This information, based on the forthcoming IARC Monographs Volume 100, offers insights into the curre... JNCI journals http://www.medworm.com/rss/comments.php?id=5523995 Tue, 20 Dec 2011 05:00:00 +0100 5523995 http://www.medworm.com/index.php?rid=5523994&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F24%2F1821%3Frss%3D1 It has been more than 30 years since the first consensus development meeting was held to deal with guidelines of mammography screening. Although the National Cancer Institute has wisely focused on the science of screening and of screening benefits vs harm, many professional organizations, advocacy groups, and the media have maintained a focus on establishing who should be screened and promoting recommendations for which age groups should be screened. Guidelines have been developed not only for mammography but also for screening at virtually all major cancer sites, especially for prostate cancer, and most recently, with the preliminary results of the National Lung Screening Trial, for lung cancer. It seems clear that we have done an inadequate job of educating screening candidates about the... JNCI journals http://www.medworm.com/rss/comments.php?id=5523994 Tue, 20 Dec 2011 05:00:00 +0100 5523994 http://www.medworm.com/index.php?rid=5523993&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F24%2F1819%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5523993 Tue, 20 Dec 2011 05:00:00 +0100 5523993 http://www.medworm.com/index.php?rid=5523992&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F24%2F1817%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5523992 Tue, 20 Dec 2011 05:00:00 +0100 5523992 http://www.medworm.com/index.php?rid=5523991&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F24%2F1815%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5523991 Tue, 20 Dec 2011 05:00:00 +0100 5523991 http://www.medworm.com/index.php?rid=5523990&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F24%2F1814%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5523990 Tue, 20 Dec 2011 05:00:00 +0100 5523990 http://www.medworm.com/index.php?rid=5523989&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F24%2F1812%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5523989 Tue, 20 Dec 2011 05:00:00 +0100 5523989 http://www.medworm.com/index.php?rid=5523988&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F24%2F1810%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5523988 Tue, 20 Dec 2011 05:00:00 +0100 5523988 http://www.medworm.com/index.php?rid=5523987&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F24%2F1808%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5523987 Tue, 20 Dec 2011 05:00:00 +0100 5523987 http://www.medworm.com/index.php?rid=5523986&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F24%2F1807%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5523986 Tue, 20 Dec 2011 05:00:00 +0100 5523986 http://www.medworm.com/index.php?rid=5523985&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F24%2FNP-d%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5523985 Tue, 20 Dec 2011 05:00:00 +0100 5523985 http://www.medworm.com/index.php?rid=5523984&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F24%2FNP-c%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5523984 Tue, 20 Dec 2011 05:00:00 +0100 5523984 http://www.medworm.com/index.php?rid=5523983&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F24%2FNP-b%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5523983 Tue, 20 Dec 2011 05:00:00 +0100 5523983 http://www.medworm.com/index.php?rid=5523982&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F24%2FNP-a%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5523982 Tue, 20 Dec 2011 05:00:00 +0100 5523982 http://www.medworm.com/index.php?rid=5523981&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F24%2FNP%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5523981 Tue, 20 Dec 2011 05:00:00 +0100 5523981 http://www.medworm.com/index.php?rid=5476080&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F23%2F1799%3Frss%3D1 In this study, we did a similar search of the electronic databases updated through December 31, 2010, and included nine trials and 2586 follicular lymphoma patients. Hazard ratios (HRs) for time-to-event data were estimated and pooled using the inverse variance method. Risk ratios for dichotomous data were pooled using a fixed effect model. Patients treated with rituximab maintenance had improved overall survival (pooled HR of death = 0.76, 95% confidence interval [CI] = 0.62 to 0.92) compared with patients in the no maintenance group. Patients with refractory or relapsed (ie, previously treated) follicular lymphoma treated with rituximab maintenance had improved overall survival (pooled HR of death = 0.72, 95% CI = 0.57 to 0.91), whereas previously untreated patients had no survival benef... JNCI journals http://www.medworm.com/rss/comments.php?id=5476080 Tue, 06 Dec 2011 05:00:00 +0100 5476080 http://www.medworm.com/index.php?rid=5476079&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F23%2F1778%3Frss%3D1 Conclusion The combination of specific DLL4–Notch blockade and ionizing radiation impairs tumor growth by promoting nonfunctional tumor angiogenesis and extensive tumor necrosis, independent of tumor DLL4 expression. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5476079 Tue, 06 Dec 2011 05:00:00 +0100 5476079 http://www.medworm.com/index.php?rid=5476078&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F23%2F1771%3Frss%3D1 Conclusions Ultrasound-guided FNAC of suspicious lymph nodes and lesions in melanoma patients has a high sensitivity and specificity, and FNAC should not be limited to palpable nodes. FNAC of normal-sized nodes and/or lymph nodes with abnormal ultrasound findings can be used to identify early metastatic disease. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5476078 Tue, 06 Dec 2011 05:00:00 +0100 5476078 http://www.medworm.com/index.php?rid=5476077&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F23%2F1761%3Frss%3D1 Conclusion Concurrent chemotherapy and radiotherapy is associated with a considerable survival benefit for patients with stage II NPC. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5476077 Tue, 06 Dec 2011 05:00:00 +0100 5476077 http://www.medworm.com/index.php?rid=5476076&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F23%2F1752%3Frss%3D1 Conclusions Bisphosphonate use was associated with a substantial reduction in risk of contralateral breast cancer. If this finding is confirmed in additional studies, nitrogenous bisphosphonate therapy may be a feasible approach for contralateral breast cancer risk reduction. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5476076 Tue, 06 Dec 2011 05:00:00 +0100 5476076 http://www.medworm.com/index.php?rid=5476075&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F23%2F1741%3Frss%3D1 Conclusions FIT should be used at higher hemoglobin cutoff levels when colonoscopy capacity is limited compared with unlimited and is more effective in terms of health outcomes and cost compared with guaiac FOBT at all colonoscopy capacity levels. Increasing the colonoscopy capacity substantially increases the health benefits of FIT screening. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5476075 Tue, 06 Dec 2011 05:00:00 +0100 5476075 http://www.medworm.com/index.php?rid=5476074&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F23%2F1738%3Frss%3D1 As recruitment for oncology clinical trials has become more difficult, there appears to have been an increase in the number of studies that allow patients in the control arm to "crossover" and receive the experimental therapy after disease progression. Although some researchers worry that allowing such crossover may abolish gains in progression-free survival in the experimental arm, the possibility that crossover might inadvertently benefit the experimental arm has not been addressed. In clinical trials in which the experimental agent has little or no intrinsic activity and is used to modulate an active combination, such crossover might negatively affect the overall survival of the control arm. Because resistance to the active combination—manifested as disease progression—has o... JNCI journals http://www.medworm.com/rss/comments.php?id=5476074 Tue, 06 Dec 2011 05:00:00 +0100 5476074 http://www.medworm.com/index.php?rid=5476073&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F23%2F1737%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5476073 Tue, 06 Dec 2011 05:00:00 +0100 5476073 http://www.medworm.com/index.php?rid=5476072&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F23%2F1736%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5476072 Tue, 06 Dec 2011 05:00:00 +0100 5476072 http://www.medworm.com/index.php?rid=5476071&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F23%2F1735%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5476071 Tue, 06 Dec 2011 05:00:00 +0100 5476071 http://www.medworm.com/index.php?rid=5476070&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F23%2F1734%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5476070 Tue, 06 Dec 2011 05:00:00 +0100 5476070 http://www.medworm.com/index.php?rid=5476069&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F23%2F1733%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5476069 Tue, 06 Dec 2011 05:00:00 +0100 5476069 http://www.medworm.com/index.php?rid=5476068&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F23%2F1731%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5476068 Tue, 06 Dec 2011 05:00:00 +0100 5476068 http://www.medworm.com/index.php?rid=5476067&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F23%2F1730%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5476067 Tue, 06 Dec 2011 05:00:00 +0100 5476067 http://www.medworm.com/index.php?rid=5476066&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F23%2F1728%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5476066 Tue, 06 Dec 2011 05:00:00 +0100 5476066 http://www.medworm.com/index.php?rid=5476065&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F23%2F1726%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5476065 Tue, 06 Dec 2011 05:00:00 +0100 5476065 http://www.medworm.com/index.php?rid=5476064&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F23%2F1725%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5476064 Tue, 06 Dec 2011 05:00:00 +0100 5476064 http://www.medworm.com/index.php?rid=5476063&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F23%2FNP-e%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5476063 Tue, 06 Dec 2011 05:00:00 +0100 5476063 http://www.medworm.com/index.php?rid=5476062&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F23%2FNP-d%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5476062 Tue, 06 Dec 2011 05:00:00 +0100 5476062 http://www.medworm.com/index.php?rid=5476061&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F23%2FNP-c%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5476061 Tue, 06 Dec 2011 05:00:00 +0100 5476061 http://www.medworm.com/index.php?rid=5476060&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F23%2FNP-b%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5476060 Tue, 06 Dec 2011 05:00:00 +0100 5476060 http://www.medworm.com/index.php?rid=5476059&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F23%2FNP-a%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5476059 Tue, 06 Dec 2011 05:00:00 +0100 5476059 http://www.medworm.com/index.php?rid=5476058&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F23%2FNP%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5476058 Tue, 06 Dec 2011 05:00:00 +0100 5476058 http://www.medworm.com/index.php?rid=5407018&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F22%2F1723%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5407018 Tue, 15 Nov 2011 05:00:00 +0100 5407018 http://www.medworm.com/index.php?rid=5407017&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F22%2F1713%3Frss%3D1 Conclusion Identification of ANRIL as a modifier gene in NF1 may offer clues to the molecular pathogenesis of PNFs, particularly neurofibroma formation, and emphasizes the unanticipated role of large noncoding RNA in activation of critical regulators of tumor development. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5407017 Tue, 15 Nov 2011 05:00:00 +0100 5407017 http://www.medworm.com/index.php?rid=5407016&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F22%2F1696%3Frss%3D1 Conclusions pIgR plays a role in the induction of EMT. Our results identify pIgR as a potential link between hepatitis B virus–derived hepatitis and HCC metastasis and provide evidence in support of pIgR as a prognostic biomarker for HCC and a potential therapeutic target. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5407016 Tue, 15 Nov 2011 05:00:00 +0100 5407016 http://www.medworm.com/index.php?rid=5407015&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F22%2F1686%3Frss%3D1 Conclusions Smoking contributed to more hepatocellular carcinomas in this Europe-wide cohort than chronic HBV and HCV infections. Heavy alcohol consumption and obesity also contributed to sizeable fractions of this disease burden. These contributions may be underestimates because EPIC volunteers are likely to be more health conscious than the general population. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5407015 Tue, 15 Nov 2011 05:00:00 +0100 5407015 http://www.medworm.com/index.php?rid=5407014&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F22%2F1676%3Frss%3D1 Conclusion The relatively low incidence of hepatocellular carcinoma and other HBV-related morbidity among chronic HBV-infected persons in Greenland suggest a more benign course of HBV among the Greenlandic Inuit than in populations in other parts of the world. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5407014 Tue, 15 Nov 2011 05:00:00 +0100 5407014 http://www.medworm.com/index.php?rid=5407013&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F22%2F1665%3Frss%3D1 Recent advances in tumor biology have made remarkable achievements in the development of therapy for metastatic castrate-resistant prostate cancer. These advances reflect a growing appreciation for the role of the tumor microenvironment in promoting prostate cancer progression. Prostate cancer is no longer viewed predominantly as a disease of abnormally proliferating epithelial cells but rather as a disease of complex interactions between prostate cancer epithelial cells (epithelial compartment) and the surrounding tissues (stromal compartment) in which they reside. For example, prostate cancers frequently metastasize to bone, an organ that contains a microenvironment rich in extracellular matrix proteins and stromal cells including hematopoietic cells, osteoblasts, osteoclasts fibroblasts... JNCI journals http://www.medworm.com/rss/comments.php?id=5407013 Tue, 15 Nov 2011 05:00:00 +0100 5407013 http://www.medworm.com/index.php?rid=5407012&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F22%2F1656%3Frss%3D1 Uncontrolled proliferation is a hallmark of cancer. In breast cancer, immunohistochemical assessment of the proportion of cells staining for the nuclear antigen Ki67 has become the most widely used method for comparing proliferation between tumor samples. Potential uses include prognosis, prediction of relative responsiveness or resistance to chemotherapy or endocrine therapy, estimation of residual risk in patients on standard therapy and as a dynamic biomarker of treatment efficacy in samples taken before, during, and after neoadjuvant therapy, particularly neoadjuvant endocrine therapy. Increasingly, Ki67 is measured in these scenarios for clinical research, including as a primary efficacy endpoint for clinical trials, and sometimes for clinical management. At present, the enormous vari... JNCI journals http://www.medworm.com/rss/comments.php?id=5407012 Tue, 15 Nov 2011 05:00:00 +0100 5407012 http://www.medworm.com/index.php?rid=5407011&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F22%2F1655%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5407011 Tue, 15 Nov 2011 05:00:00 +0100 5407011 http://www.medworm.com/index.php?rid=5407010&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F22%2F1654%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5407010 Tue, 15 Nov 2011 05:00:00 +0100 5407010 http://www.medworm.com/index.php?rid=5407009&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F22%2F1652%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5407009 Tue, 15 Nov 2011 05:00:00 +0100 5407009 http://www.medworm.com/index.php?rid=5407008&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F22%2F1650%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5407008 Tue, 15 Nov 2011 05:00:00 +0100 5407008 http://www.medworm.com/index.php?rid=5407007&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F22%2F1648%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5407007 Tue, 15 Nov 2011 05:00:00 +0100 5407007 http://www.medworm.com/index.php?rid=5407006&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F22%2F1646%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5407006 Tue, 15 Nov 2011 05:00:00 +0100 5407006 http://www.medworm.com/index.php?rid=5407005&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F22%2F1644%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5407005 Tue, 15 Nov 2011 05:00:00 +0100 5407005 http://www.medworm.com/index.php?rid=5407004&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F22%2F1642%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5407004 Tue, 15 Nov 2011 05:00:00 +0100 5407004 http://www.medworm.com/index.php?rid=5407003&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F22%2F1641%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5407003 Tue, 15 Nov 2011 05:00:00 +0100 5407003 http://www.medworm.com/index.php?rid=5407002&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F22%2FNP-d%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5407002 Tue, 15 Nov 2011 05:00:00 +0100 5407002 http://www.medworm.com/index.php?rid=5407001&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F22%2FNP-c%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5407001 Tue, 15 Nov 2011 05:00:00 +0100 5407001 http://www.medworm.com/index.php?rid=5407000&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F22%2FNP-b%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5407000 Tue, 15 Nov 2011 05:00:00 +0100 5407000 http://www.medworm.com/index.php?rid=5406999&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F22%2FNP-a%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5406999 Tue, 15 Nov 2011 05:00:00 +0100 5406999 http://www.medworm.com/index.php?rid=5406998&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F22%2FNP%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5406998 Tue, 15 Nov 2011 05:00:00 +0100 5406998 http://www.medworm.com/index.php?rid=5384338&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F21%2F1639%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5384338 Tue, 01 Nov 2011 04:00:00 +0100 5384338 http://www.medworm.com/index.php?rid=5384337&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F21%2F1637-a%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5384337 Tue, 01 Nov 2011 04:00:00 +0100 5384337 http://www.medworm.com/index.php?rid=5384336&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F21%2F1637%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5384336 Tue, 01 Nov 2011 04:00:00 +0100 5384336 http://www.medworm.com/index.php?rid=5384335&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F21%2F1636%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5384335 Tue, 01 Nov 2011 04:00:00 +0100 5384335 http://www.medworm.com/index.php?rid=5384333&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F21%2F1630%3Frss%3D1 In screening for epithelial ovarian cancer, unnecessary surgery can be reduced by limiting use of transvaginal ultrasound (TVU) to women with increasing CA125 serum levels. Replacing or augmenting TVU with measurement of a serum marker specific for malignancy might further improve screening performance. Serum samples from 112 invasive ovarian cancer patients and 706 matched control subjects from the Prostate, Lung, Colorectal, and Ovarian trial were used to evaluate human epididymis protein 4 (HE4), mesothelin, matrix metalloproteinase 7 (MMP7), SLPI, Spondin2, and insulin-like growth factor binding protein 2 (IGFBP2) for their potential use in screening. TVU results were available for a subset of 84 patients and 516 control subjects used to compare the best marker with TVU. HE4 was found ... JNCI journals http://www.medworm.com/rss/comments.php?id=5384333 Tue, 01 Nov 2011 04:00:00 +0100 5384333 http://www.medworm.com/index.php?rid=5384332&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F21%2F1621%3Frss%3D1 Conclusions Evidence is statistically inconclusive but suggestive that lobectomy, compared with limited resection, is associated with increased long-term survival for early-stage lung cancer. Clinical, socioeconomic, and surgeon factors appear to be associated with the choice of surgical resection. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5384332 Tue, 01 Nov 2011 04:00:00 +0100 5384332 http://www.medworm.com/index.php?rid=5384331&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F21%2F1613%3Frss%3D1 Conclusions We developed a highly accurate tool that uses basic clinical and analytical information to predict the probability of survival at 15, 30, and 60 days in terminally ill cancer patients. This tool can help physicians making decisions on clinical care at the end of life. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5384331 Tue, 01 Nov 2011 04:00:00 +0100 5384331 http://www.medworm.com/index.php?rid=5384330&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F21%2F1596%3Frss%3D1 Conclusions Increased p130cas expression is associated with poor clinical outcome in human ovarian carcinoma, and p130cas gene silencing decreases tumor growth through stimulation of apoptotic and autophagic cell death. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5384330 Tue, 01 Nov 2011 04:00:00 +0100 5384330 http://www.medworm.com/index.php?rid=5384329&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F21%2F1588%3Frss%3D1 Conclusions Overall, our prospective findings are consistent with recent retrospective studies and support an association between total IgE levels and glioma. However, this association requires further elucidation. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5384329 Tue, 01 Nov 2011 04:00:00 +0100 5384329 http://www.medworm.com/index.php?rid=5384328&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F21%2F1572%3Frss%3D1 Unlike cytotoxic agents that indiscriminately affect rapidly dividing cells, newer antineoplastic agents such as targeted therapies and immunotherapies are associated with thyroid dysfunction. These include tyrosine kinase inhibitors, bexarotene, radioiodine-based cancer therapies, denileukin diftitox, alemtuzumab, interferon-α, interleukin-2, ipilimumab, tremelimumab, thalidomide, and lenalidomide. Primary hypothyroidism is the most common side effect, although thyrotoxicosis and effects on thyroid-stimulating hormone secretion and thyroid hormone metabolism have also been described. Most agents cause thyroid dysfunction in 20%–50% of patients, although some have even higher rates. Despite this, physicians may overlook drug-induced thyroid dysfunction because of the complexity... JNCI journals http://www.medworm.com/rss/comments.php?id=5384328 Tue, 01 Nov 2011 04:00:00 +0100 5384328 http://www.medworm.com/index.php?rid=5384327&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F103%2F21%2F1570%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=5384327 Tue, 01 Nov 2011 04:00:00 +0100 5384327