JNCI via MedWorm.com MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'JNCI' source. Sun, 21 Mar 2010 13:52:42 +0100 Roles of Arrest-Defective Protein 1225 and Hypoxia-Inducible Factor 1{alpha} in Tumor Growth and Metastasis http://www.medworm.com/index.php?rid=3375396&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F6%2F426%3Frss%3D1 Conclusion mARD1A225 may be a novel upstream target that blocks VEGFA expression and tumor-related angiogenesis. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3375396 Wed, 17 Mar 2010 20:01:15 +0100 3375396 Breast Cancer Prognosis and Occult Lymph Node Metastases, Isolated Tumor Cells, and Micrometastases http://www.medworm.com/index.php?rid=3375395&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F6%2F410%3Frss%3D1 Conclusion The presence (vs the absence) of metastases of 2 mm or less in diameter in axillary lymph nodes detected on single-section examination was associated with poorer disease-free and overall survival. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3375395 Wed, 17 Mar 2010 20:01:15 +0100 3375395 Population-Based Study of Contralateral Prophylactic Mastectomy and Survival Outcomes of Breast Cancer Patients http://www.medworm.com/index.php?rid=3375394&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F6%2F401%3Frss%3D1 Conclusions CPM is associated with a small improvement in 5-year breast cancer–specific survival mainly in young women with early-stage ER-negative breast cancer. This effect is related to a higher baseline risk of contralateral breast cancer. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3375394 Wed, 17 Mar 2010 20:01:15 +0100 3375394 Case-Control Study of Overweight, Obesity, and Colorectal Cancer Risk, Overall and by Tumor Microsatellite Instability Status http://www.medworm.com/index.php?rid=3375393&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F6%2F391%3Frss%3D1 Conclusion The increased risk of colorectal cancer associated with a high BMI might be largely restricted to tumors that display the more common MS-stable phenotype, suggesting further that colorectal cancer etiology differs by tumor MSI status. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3375393 Wed, 17 Mar 2010 20:01:15 +0100 3375393 State Payer Mandates to Cover Care in US Oncology Trials: Do Science and Ethics Matter? http://www.medworm.com/index.php?rid=3375392&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F6%2F376%3Frss%3D1 Conclusions Most states did not demand independent scientific review, IRB review, or basic ethical features of high-quality trials; provided partial coverage; omitted prevention, detection, and palliation research; and omitted mandated coverage for research-related injuries. Few required evaluation, independence in publication, or posting trial results. Further research on the impact of diverse state choices would improve policy making. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3375392 Wed, 17 Mar 2010 20:01:15 +0100 3375392 Breast Density Gains Acceptance As Breast Cancer Risk Factor http://www.medworm.com/index.php?rid=3375391&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F6%2F374%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3375391 Wed, 17 Mar 2010 20:01:15 +0100 3375391 StatBite: Cancer in Patients With Parkinson's Disease http://www.medworm.com/index.php?rid=3375390&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F6%2F373%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3375390 Wed, 17 Mar 2010 20:01:15 +0100 3375390 Parkinson's Disease and Cancer: The Unexplored Connection http://www.medworm.com/index.php?rid=3375389&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F6%2F371%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3375389 Wed, 17 Mar 2010 20:01:15 +0100 3375389 Aberrant Chromosomes: Teams Use Math Models To Sort Drivers From Passengers http://www.medworm.com/index.php?rid=3375388&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F6%2F369%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3375388 Wed, 17 Mar 2010 20:01:15 +0100 3375388 Aberrant Chromosomes: Not So Random After All? http://www.medworm.com/index.php?rid=3375387&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F6%2F368%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3375387 Wed, 17 Mar 2010 20:01:15 +0100 3375387 Lifestyle Factors and Microsatellite Instability in Colorectal Cancer: The Evolving Field of Molecular Pathological Epidemiology http://www.medworm.com/index.php?rid=3375386&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F6%2F365%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3375386 Wed, 17 Mar 2010 20:01:14 +0100 3375386 In this issue http://www.medworm.com/index.php?rid=3375385&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F6%2F363%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3375385 Wed, 17 Mar 2010 20:01:14 +0100 3375385 Table of Contents http://www.medworm.com/index.php?rid=3375384&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F6%2FNP-e%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3375384 Wed, 17 Mar 2010 20:01:14 +0100 3375384 Japanese journal of clinical oncology http://www.medworm.com/index.php?rid=3375383&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F6%2FNP-d%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3375383 Wed, 17 Mar 2010 20:01:14 +0100 3375383 Editorial board http://www.medworm.com/index.php?rid=3375382&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F6%2FNP-c%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3375382 Wed, 17 Mar 2010 20:01:14 +0100 3375382 Cover http://www.medworm.com/index.php?rid=3375381&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F6%2FNP-b%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3375381 Wed, 17 Mar 2010 20:01:14 +0100 3375381 High Body Weight Associated With Higher Risk of Colorectal Tumors Without Microsatellite Instability http://www.medworm.com/index.php?rid=3375380&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F6%2FNP-a%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3375380 Wed, 17 Mar 2010 20:01:14 +0100 3375380 State Payer Mandates to Cover Cancer Clinical Trials Offer Heterogeneous Protection for Enrolled Patients http://www.medworm.com/index.php?rid=3375379&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F6%2FNP%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3375379 Wed, 17 Mar 2010 20:01:14 +0100 3375379 Unusual Cancer Excess After Neonatal Arsenic Exposure From Contaminated Milk Powder http://www.medworm.com/index.php?rid=3323669&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F5%2F360%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3323669 Tue, 02 Mar 2010 21:01:23 +0100 3323669 Response Re: Cost-Effectiveness Analysis of Human Papillomavirus Vaccination in the Netherlands http://www.medworm.com/index.php?rid=3323668&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F5%2F359%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3323668 Tue, 02 Mar 2010 21:01:23 +0100 3323668 Response: Re: Cost-Effectiveness Analysis of Human Papillomavirus Vaccination in the Netherlands http://www.medworm.com/index.php?rid=3323667&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F5%2F358-b%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3323667 Tue, 02 Mar 2010 21:01:23 +0100 3323667 Response: Re: Cost-Effectiveness Analysis of Human Papillomavirus Vaccination in the Netherlands http://www.medworm.com/index.php?rid=3323666&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F5%2F358-a%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3323666 Tue, 02 Mar 2010 21:01:23 +0100 3323666 Re: Cost-Effectiveness Analysis of Human Papillomavirus Vaccination in the Netherlands http://www.medworm.com/index.php?rid=3323665&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F5%2F358%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3323665 Tue, 02 Mar 2010 21:01:23 +0100 3323665 Response: Re: Public Knowledge of Benefits of Breast and Prostate Cancer Screening in Europe http://www.medworm.com/index.php?rid=3323664&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F5%2F356-a%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3323664 Tue, 02 Mar 2010 21:01:23 +0100 3323664 Re: Public Knowledge of Benefits of Breast and Prostate Cancer Screening in Europe http://www.medworm.com/index.php?rid=3323663&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F5%2F356%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3323663 Tue, 02 Mar 2010 21:01:23 +0100 3323663 Prostate-Specific Antigen Screening in the United States vs in the European Randomized Study of Screening for Prostate Cancer-Rotterdam http://www.medworm.com/index.php?rid=3323662&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F5%2F352%3Frss%3D1 Dissemination of prostate-specific antigen (PSA) testing in the United States coincided with an increasing incidence of prostate cancer, a shift to earlier stage disease at diagnosis, and decreasing prostate cancer mortality. We compared PSA screening performance with respect to prostate cancer detection in the US population vs in the Rotterdam section of the European Randomized Study of Screening for Prostate Cancer (ERSPC–Rotterdam). We developed a simulation model for prostate cancer and PSA screening for ERSPC–Rotterdam. This model was then adapted to the US population by replacing demography parameters with US-specific ones and the screening protocol with the frequency of PSA tests in the US population. We assumed that the natural progression of prostate cancer and the sen... JNCI journals http://www.medworm.com/rss/comments.php?id=3323662 Tue, 02 Mar 2010 21:01:22 +0100 3323662 Prognostic Significance of Tumorigenic Cells With Mesenchymal Features in Pancreatic Adenocarcinoma http://www.medworm.com/index.php?rid=3323661&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F5%2F340%3Frss%3D1 Conclusions ALDH expression marks pancreatic cancer cells that have stem cell and mesenchymal features. The enhanced clonogenic growth and migratory properties of ALDH-positive pancreatic cancer cells suggest that they play a key role in the development of metastatic disease that negatively affects the overall survival of patients with pancreatic adenocarcinoma. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3323661 Tue, 02 Mar 2010 21:01:22 +0100 3323661 Impact of Human Papillomavirus (HPV)-6/11/16/18 Vaccine on All HPV-Associated Genital Diseases in Young Women http://www.medworm.com/index.php?rid=3323660&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F5%2F325%3Frss%3D1 Conclusions High-coverage HPV vaccination programs among adolescents and young women may result in a rapid reduction of genital warts, cervical cytological abnormalities, and diagnostic and therapeutic procedures. In the longer term, substantial reductions in the rates of cervical, vulvar, and vaginal cancers may follow. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3323660 Tue, 02 Mar 2010 21:01:22 +0100 3323660 Longitudinal Study of Human Papillomavirus Persistence and Cervical Intraepithelial Neoplasia Grade 2/3: Critical Role of Duration of Infection http://www.medworm.com/index.php?rid=3323659&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F5%2F315%3Frss%3D1 Conclusions The rate of new infections declines with age, and new infections typically do not progress to CIN 2 or worse disease in older women; thus, overall potential benefit of prophylactic vaccination or frequent HPV screening to prevent or detect new carcinogenic HPV infections at older ages is low. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3323659 Tue, 02 Mar 2010 21:01:22 +0100 3323659 Immediate Risk of Suicide and Cardiovascular Death After a Prostate Cancer Diagnosis: Cohort Study in the United States http://www.medworm.com/index.php?rid=3323658&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F5%2F307%3Frss%3D1 Conclusion A diagnosis of prostate cancer may increase the immediate risks of suicide and cardiovascular death. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3323658 Tue, 02 Mar 2010 21:01:22 +0100 3323658 Economic Analysis: Randomized Placebo-Controlled Clinical Trial of Erlotinib in Advanced Non-Small Cell Lung Cancer http://www.medworm.com/index.php?rid=3323657&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F5%2F298%3Frss%3D1 Conclusion With an incremental cost-effectiveness ratio of $94 638 per life-year gained, erlotinib treatment for patients with previously treated advanced non–small cell lung cancer is marginally cost-effective. The use of molecular predictors of benefit for targeted agents may help identify more or less cost-effective subgroups for treatment. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3323657 Tue, 02 Mar 2010 21:01:22 +0100 3323657 Movement of Genes in Nucleus May Someday Aid Diagnosis http://www.medworm.com/index.php?rid=3323656&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F5%2F296%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3323656 Tue, 02 Mar 2010 21:01:22 +0100 3323656 Fertility Preservation During Treatment Is a Growing Issue for Women http://www.medworm.com/index.php?rid=3323655&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F5%2F294%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3323655 Tue, 02 Mar 2010 21:01:22 +0100 3323655 StatBite: Key Findings from the "Impact on Clinical Research of European Legislation" Report http://www.medworm.com/index.php?rid=3323654&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F5%2F293%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3323654 Tue, 02 Mar 2010 21:01:22 +0100 3323654 European Commission Considers Revisions to Clinical Trials Directive http://www.medworm.com/index.php?rid=3323653&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F5%2F292%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3323653 Tue, 02 Mar 2010 21:01:22 +0100 3323653 New Law May Be Having Some Effect on Publication Bias http://www.medworm.com/index.php?rid=3323652&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F5%2F290%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3323652 Tue, 02 Mar 2010 21:01:22 +0100 3323652 Efficacy vs Effectiveness in Prostate-Specific Antigen Screening http://www.medworm.com/index.php?rid=3323651&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F5%2F288%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3323651 Tue, 02 Mar 2010 21:01:22 +0100 3323651 Economics and the New Generation of Targeted Therapies for Non-Small Cell Lung Cancer http://www.medworm.com/index.php?rid=3323650&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F5%2F287%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3323650 Tue, 02 Mar 2010 21:01:22 +0100 3323650 In this issue http://www.medworm.com/index.php?rid=3323649&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F5%2F285%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3323649 Tue, 02 Mar 2010 21:01:22 +0100 3323649 Table of Contents http://www.medworm.com/index.php?rid=3323648&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F5%2FNP-e%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3323648 Tue, 02 Mar 2010 21:01:22 +0100 3323648 Japanese journal of clinical oncology http://www.medworm.com/index.php?rid=3323647&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F5%2FNP-d%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3323647 Tue, 02 Mar 2010 21:01:22 +0100 3323647 Editorial board http://www.medworm.com/index.php?rid=3323646&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F5%2FNP-c%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3323646 Tue, 02 Mar 2010 21:01:22 +0100 3323646 Cover http://www.medworm.com/index.php?rid=3323645&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F5%2FNP-b%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3323645 Tue, 02 Mar 2010 21:01:22 +0100 3323645 Immediate Risk of Suicide and Cardiovascular Death After a Prostate Cancer Diagnosis http://www.medworm.com/index.php?rid=3323644&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F5%2FNP-a%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3323644 Tue, 02 Mar 2010 21:01:22 +0100 3323644 Economic Analysis: Erlotinib Marginally Cost-Effective http://www.medworm.com/index.php?rid=3323643&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F5%2FNP%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3323643 Tue, 02 Mar 2010 21:01:22 +0100 3323643 Retraction: A Genetically Enhanced Anaerobic Bacterium for Oncopathic Therapy of Pancreatic Cancer http://www.medworm.com/index.php?rid=3295480&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F4%2F283%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3295480 Mon, 22 Feb 2010 16:06:25 +0100 3295480 Erratum http://www.medworm.com/index.php?rid=3295479&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F4%2F282%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3295479 Mon, 22 Feb 2010 16:06:25 +0100 3295479 Response: Re: Racial Disparities in Cancer Survival Among Randomized Clinical Trials of the Southwest Oncology Group http://www.medworm.com/index.php?rid=3295478&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F4%2F280-a%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3295478 Mon, 22 Feb 2010 16:06:25 +0100 3295478 Re: Racial Disparities in Cancer Survival Among Randomized Clinical Trials of the Southwest Oncology Group http://www.medworm.com/index.php?rid=3295477&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F4%2F280%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3295477 Mon, 22 Feb 2010 16:06:25 +0100 3295477 Re: Racial Disparities in Cancer Survival Among Randomized Clinical Trials of the Southwest Oncology Group http://www.medworm.com/index.php?rid=3295476&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F4%2F279%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3295476 Mon, 22 Feb 2010 16:06:24 +0100 3295476 Re: Racial Disparities in Cancer Survival Among Randomized Clinical Trials of the Southwest Oncology Group http://www.medworm.com/index.php?rid=3295475&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F4%2F278%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3295475 Mon, 22 Feb 2010 16:06:24 +0100 3295475 Re: Racial Disparities in Cancer Survival Among Randomized Clinical Trials of the Southwest Oncology Group http://www.medworm.com/index.php?rid=3295474&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F4%2F277-a%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3295474 Mon, 22 Feb 2010 16:06:24 +0100 3295474 Re: Racial Disparities in Cancer Survival Among Randomized Clinical Trials of the Southwest Oncology Group http://www.medworm.com/index.php?rid=3295473&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F4%2F277%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3295473 Mon, 22 Feb 2010 16:06:24 +0100 3295473 Response: Re: Population-Based Study of Peritumoral Lymphovascular Invasion and Outcome Among Patients With Operable Breast Cancer http://www.medworm.com/index.php?rid=3295472&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F4%2F276%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3295472 Mon, 22 Feb 2010 16:06:24 +0100 3295472 Re: Population-Based Study of Peritumoral Lymphovascular Invasion and Outcome Among Patients With Operable Breast Cancer http://www.medworm.com/index.php?rid=3295471&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F4%2F275%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3295471 Mon, 22 Feb 2010 16:06:24 +0100 3295471 Verification and Unmasking of Widely Used Human Esophageal Adenocarcinoma Cell Lines http://www.medworm.com/index.php?rid=3295470&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F4%2F271%3Frss%3D1 For decades, hundreds of different human tumor type–specific cell lines have been used in experimental cancer research as models for their respective tumors. The veracity of experimental results for a specific tumor type relies on the correct derivation of the cell line. In a worldwide effort, we verified the authenticity of all available esophageal adenocarcinoma (EAC) cell lines. We proved that the frequently used cell lines SEG-1 and BIC-1 and the SK-GT-5 cell line are in fact cell lines from other tumor types. Experimental results based on these contaminated cell lines have led to ongoing clinical trials recruiting EAC patients, to more than 100 scientific publications, and to at least three National Institutes of Health cancer research grants and 11 US patents, which emphasizes ... JNCI journals http://www.medworm.com/rss/comments.php?id=3295470 Mon, 22 Feb 2010 16:06:24 +0100 3295470 Educational Attainment Among Adult Survivors of Childhood Cancer in Great Britain: A Population-Based Cohort Study http://www.medworm.com/index.php?rid=3295469&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F4%2F254%3Frss%3D1 Conclusions Specific groups of childhood cancer survivors achieve lower-than-expected educational attainment. Detailed educational support and implementation of regular cognitive assessment may be indicated for some groups to maximize long-term function. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3295469 Mon, 22 Feb 2010 16:06:24 +0100 3295469 Detection of Lymph Node Metastases by Gadolinium-Enhanced Magnetic Resonance Imaging: Systematic Review and Meta-analysis http://www.medworm.com/index.php?rid=3295468&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F4%2F244%3Frss%3D1 Conclusions The overall accuracy of gadolinium-enhanced magnetic resonance imaging for the detection of nodal metastases is moderate. Incorporating contrast enhancement in the malignancy criteria substantially improves the accuracy of this diagnostic test. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3295468 Mon, 22 Feb 2010 16:06:23 +0100 3295468 Review of Oncology and Hematology Drug Product Approvals at the US Food and Drug Administration Between July 2005 and December 2007 http://www.medworm.com/index.php?rid=3295467&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F4%2F230%3Frss%3D1 Conclusion During the study period, regulatory action was taken on 58 of the 60 marketing applications. Fifty-three applications were approved. A variety of clinical trial endpoints were used in the approval trials. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3295467 Mon, 22 Feb 2010 16:06:23 +0100 3295467 Predictive Value of Symptoms for Early Detection of Ovarian Cancer http://www.medworm.com/index.php?rid=3295466&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F4%2F222%3Frss%3D1 Conclusion Use of symptoms to trigger medical evaluation for ovarian cancer is likely to result in diagnosis of the disease in only one of 100 women in the general population with such symptoms. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3295466 Mon, 22 Feb 2010 16:06:23 +0100 3295466 Indolent Lymphoma: Can Rituximab Resolve the Watch-and-Wait Debate? http://www.medworm.com/index.php?rid=3295465&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F4%2F220%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3295465 Mon, 22 Feb 2010 16:06:23 +0100 3295465 StatBite: FDA Oncology Drug Product Approvals in 2009 http://www.medworm.com/index.php?rid=3295464&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F4%2F219%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3295464 Mon, 22 Feb 2010 16:06:23 +0100 3295464 In Silico Research: Pushing It Into the Mainstream http://www.medworm.com/index.php?rid=3295463&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F4%2F217%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3295463 Mon, 22 Feb 2010 16:06:23 +0100 3295463 Big Databases: Outcomes Research Begins To Yield Results http://www.medworm.com/index.php?rid=3295462&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F4%2F215%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3295462 Mon, 22 Feb 2010 16:06:23 +0100 3295462 BRAF Inhibitors: Research Accelerates in Wake of Positive Findings http://www.medworm.com/index.php?rid=3295461&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F4%2F214%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3295461 Mon, 22 Feb 2010 16:06:22 +0100 3295461 Identification of Bona Fide Esophageal Adenocarcinoma Cell Lines http://www.medworm.com/index.php?rid=3295460&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F4%2F212%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3295460 Mon, 22 Feb 2010 16:06:22 +0100 3295460 Ovarian Cancer Symptoms Speak Out--But What Are They Really Saying? http://www.medworm.com/index.php?rid=3295459&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F4%2F211%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3295459 Mon, 22 Feb 2010 16:06:22 +0100 3295459 In this issue http://www.medworm.com/index.php?rid=3295458&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F4%2F209%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3295458 Mon, 22 Feb 2010 16:06:22 +0100 3295458 Table of Contents http://www.medworm.com/index.php?rid=3295457&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F4%2FNP-f%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3295457 Mon, 22 Feb 2010 16:06:22 +0100 3295457 Japanese journal of clinical oncology http://www.medworm.com/index.php?rid=3295456&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F4%2FNP-e%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3295456 Mon, 22 Feb 2010 16:06:22 +0100 3295456 Editorial board http://www.medworm.com/index.php?rid=3295455&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F4%2FNP-d%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3295455 Mon, 22 Feb 2010 16:06:22 +0100 3295455 Cover http://www.medworm.com/index.php?rid=3295454&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F4%2FNP-c%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3295454 Mon, 22 Feb 2010 16:06:22 +0100 3295454 Review and Approval of Oncology and Hematology Drugs at FDA from 2005 to 2007 http://www.medworm.com/index.php?rid=3295453&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F4%2FNP-b%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3295453 Mon, 22 Feb 2010 16:06:21 +0100 3295453 Symptoms Have Little Value for Early Detection of Ovarian Cancer http://www.medworm.com/index.php?rid=3295452&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F4%2FNP-a%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3295452 Mon, 22 Feb 2010 16:06:21 +0100 3295452 Three Esophageal Cancer Cell Lines Commonly Used in Research Prove to be from Other Cancers http://www.medworm.com/index.php?rid=3295451&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F4%2FNP%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3295451 Mon, 22 Feb 2010 16:06:21 +0100 3295451 Erratum http://www.medworm.com/index.php?rid=3291531&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F3%2F208%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3291531 Sat, 20 Feb 2010 14:51:13 +0100 3291531 Erratum http://www.medworm.com/index.php?rid=3232686&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F3%2F208-a%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3232686 Tue, 02 Feb 2010 21:01:32 +0100 3232686 Response: Re: International Guidelines for Management of Metastatic Breast Cancer: Combination vs Sequential Single-Agent Chemotherapy http://www.medworm.com/index.php?rid=3232685&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F3%2F207-a%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3232685 Tue, 02 Feb 2010 21:01:32 +0100 3232685 Re: International Guidelines for Management of Metastatic Breast Cancer: Combination vs Sequential Single-Agent Chemotherapy http://www.medworm.com/index.php?rid=3232684&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F3%2F207%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3232684 Tue, 02 Feb 2010 21:01:32 +0100 3232684 C-Reactive Protein and the Risk of Cancer: A Mendelian Randomization Study http://www.medworm.com/index.php?rid=3232683&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F3%2F202%3Frss%3D1 We examined whether four common single-nucleotide polymorphisms (SNPs) in the CRP gene that are associated with altered plasma CRP levels are causally associated with an increased risk of cancer. The study population included participants in a prospective study (n = 10 215) and a cross-sectional study (n = 36 403) of the adult general population in Denmark, all of whom were genotyped for the CRP SNPs. The association between plasma CRP levels measured by a high-sensitivity turbidimetry assay and the risk of cancer was examined for 8224 participants in the prospective study. The hazard ratio of cancer for a doubling of the plasma CRP level was 1.09 (95% confidence interval [CI] = 1.03 to 1.14). The nine most common genotype combinations of the four CRP SNPs were associated with up to a 72% ... JNCI journals http://www.medworm.com/rss/comments.php?id=3232683 Tue, 02 Feb 2010 21:01:32 +0100 3232683 Risks of Lynch Syndrome Cancers for MSH6 Mutation Carriers http://www.medworm.com/index.php?rid=3232682&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F3%2F193%3Frss%3D1 Conclusion We have obtained precise and accurate estimates of both absolute and relative cancer risks for MSH6 mutation carriers. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3232682 Tue, 02 Feb 2010 21:01:32 +0100 3232682 Familial Coaggregation of Cryptorchidism, Hypospadias, and Testicular Germ Cell Cancer: A Nationwide Cohort Study http://www.medworm.com/index.php?rid=3232681&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F3%2F187%3Frss%3D1 Conclusions Having hypospadias or cryptorchidism was associated with an increased risk of developing TGCC. However, our finding that family history of hypospadias or cryptorchidism generally was not associated with increased risk of developing TGCC does not support the hypothesis of shared inheritability of cryptorchidism, hypospadias, and TGCC. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3232681 Tue, 02 Feb 2010 21:01:32 +0100 3232681 Population-Based Case-Control Study of Chinese Herbal Products Containing Aristolochic Acid and Urinary Tract Cancer Risk http://www.medworm.com/index.php?rid=3232680&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F3%2F179%3Frss%3D1 Conclusions Consumption of aristolochic acid–containing Chinese herbal products is associated with an increased risk of cancer of the urinary tract in a dose-dependent manner that is independent of arsenic exposure. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3232680 Tue, 02 Feb 2010 21:01:32 +0100 3232680 Ductal Carcinoma In Situ of the Breast: A Systematic Review of Incidence, Treatment, and Outcomes http://www.medworm.com/index.php?rid=3232679&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F3%2F170%3Frss%3D1 Conclusions Scientific questions deserving further investigation include the relationship between mammography use and DCIS incidence and whether imaging technologies and treatment guidelines can be modified to focus on lesions that are most likely to become clinically problematic. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3232679 Tue, 02 Feb 2010 21:01:32 +0100 3232679 National Institutes of Health State-of-the-Science Conference Statement: Diagnosis and Management of Ductal Carcinoma In Situ September 22-24, 2009 http://www.medworm.com/index.php?rid=3232678&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F3%2F161%3Frss%3D1 Conclusions Clearly, the diagnosis and management of DCIS is highly complex with many unanswered questions, including the fundamental natural history of untreated disease. Because of the noninvasive nature of DCIS, coupled with its favorable prognosis, strong consideration should be given to elimination of the use of the anxiety-producing term "carcinoma" from the description of DCIS. The outcomes in women treated with available therapies are excellent. Thus, the primary question for future research must focus on the accurate identification of patient subsets diagnosed with DCIS, including those persons who may be managed with less therapeutic intervention without sacrificing the excellent outcomes presently achieved. Essential in this quest will be the development and validation of accura... JNCI journals http://www.medworm.com/rss/comments.php?id=3232678 Tue, 02 Feb 2010 21:01:32 +0100 3232678 Randomized Clinical Trials With Biomarkers: Design Issues http://www.medworm.com/index.php?rid=3232677&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F3%2F152%3Frss%3D1 Clinical biomarker tests that aid in making treatment decisions will play an important role in achieving personalized medicine for cancer patients. Definitive evaluation of the clinical utility of these biomarkers requires conducting large randomized clinical trials (RCTs). Efficient RCT design is therefore crucial for timely introduction of these medical advances into clinical practice, and a variety of designs have been proposed for this purpose. To guide design and interpretation of RCTs evaluating biomarkers, we present an in-depth comparison of advantages and disadvantages of the commonly used designs. Key aspects of the discussion include efficiency comparisons and special interim monitoring issues that arise because of the complexity of these RCTs. Important ongoing and completed tr... JNCI journals http://www.medworm.com/rss/comments.php?id=3232677 Tue, 02 Feb 2010 21:01:32 +0100 3232677 Awards, Appointments, Announcements http://www.medworm.com/index.php?rid=3232676&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F3%2F151%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3232676 Tue, 02 Feb 2010 21:01:32 +0100 3232676 StatBite: New Drug Approvals in Japan: A comparison of Review Times and Number of Employees http://www.medworm.com/index.php?rid=3232675&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F3%2F150%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3232675 Tue, 02 Feb 2010 21:01:31 +0100 3232675 Japan Works To Shorten "Drug Lag," Boost Trials of New Drugs http://www.medworm.com/index.php?rid=3232674&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F3%2F148%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3232674 Tue, 02 Feb 2010 21:01:31 +0100 3232674 Circulating Tumor Cells: Will They Be Clinically Useful? http://www.medworm.com/index.php?rid=3232673&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F3%2F146%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3232673 Tue, 02 Feb 2010 21:01:31 +0100 3232673 Researchers Consider Value-of-Information Theory for Selecting Trials http://www.medworm.com/index.php?rid=3232672&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F3%2F144%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3232672 Tue, 02 Feb 2010 21:01:31 +0100 3232672 Exploring a Cancer Biomarker: The Example of C-Reactive Protein http://www.medworm.com/index.php?rid=3232671&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F3%2F142%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3232671 Tue, 02 Feb 2010 21:01:31 +0100 3232671 In this issue http://www.medworm.com/index.php?rid=3232670&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F3%2F141%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3232670 Tue, 02 Feb 2010 21:01:31 +0100 3232670 Cover http://www.medworm.com/index.php?rid=3232669&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F3%2FNP-e%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3232669 Tue, 02 Feb 2010 21:01:31 +0100 3232669 Editorial board http://www.medworm.com/index.php?rid=3232668&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F3%2FNP-d%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3232668 Tue, 02 Feb 2010 21:01:31 +0100 3232668 Japanese journal of clinical oncology http://www.medworm.com/index.php?rid=3232667&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F3%2FNP-c%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3232667 Tue, 02 Feb 2010 21:01:31 +0100 3232667 Table of Contents http://www.medworm.com/index.php?rid=3232666&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F3%2FNP-b%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3232666 Tue, 02 Feb 2010 21:01:31 +0100 3232666 Researchers Tackle Ductal Carcinoma in Situ and Its Many Unanswered Questions http://www.medworm.com/index.php?rid=3232665&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F3%2FNP-a%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3232665 Tue, 02 Feb 2010 21:01:31 +0100 3232665 Urinary Tract Cancer Associated with Chinese Herbal Products Containing Aristolochic Acid http://www.medworm.com/index.php?rid=3232664&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F3%2FNP%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3232664 Tue, 02 Feb 2010 21:01:31 +0100 3232664 Erratum: http://www.medworm.com/index.php?rid=3186585&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F2%2F140-a%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3186585 Tue, 19 Jan 2010 21:01:59 +0100 3186585 Erratum: http://www.medworm.com/index.php?rid=3186584&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F2%2F140%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3186584 Tue, 19 Jan 2010 21:01:59 +0100 3186584 Erratum: http://www.medworm.com/index.php?rid=3186583&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F2%2F138%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3186583 Tue, 19 Jan 2010 21:01:59 +0100 3186583 Re: International Guidelines for Management of Metastatic Breast Cancer: Combination vs Sequential Single-Agent Chemotherapy http://www.medworm.com/index.php?rid=3186582&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F2%2F137-a%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3186582 Tue, 19 Jan 2010 21:01:59 +0100 3186582 Response: Re: ABO Blood Group and the Risk of Pancreatic Cancer http://www.medworm.com/index.php?rid=3186581&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F2%2F137%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3186581 Tue, 19 Jan 2010 21:01:58 +0100 3186581 Re: ABO Blood Group and the Risk of Pancreatic Cancer http://www.medworm.com/index.php?rid=3186580&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F2%2F135%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3186580 Tue, 19 Jan 2010 21:01:58 +0100 3186580 Response: Re: False-Positive Results in Cancer Epidemiology: A Plea for Epistemological Modesty http://www.medworm.com/index.php?rid=3186579&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F2%2F134-a%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3186579 Tue, 19 Jan 2010 21:01:57 +0100 3186579 Re: False-Positive Results in Cancer Epidemiology: A Plea for Epistemological Modesty http://www.medworm.com/index.php?rid=3186578&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F2%2F134%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3186578 Tue, 19 Jan 2010 21:01:57 +0100 3186578 E2F1 in Melanoma Progression and Metastasis http://www.medworm.com/index.php?rid=3186577&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F2%2F127%3Frss%3D1 Metastases are responsible for cancer deaths, but the molecular alterations leading to tumor progression are unclear. Overexpression of the E2F1 transcription factor is common in high-grade tumors that are associated with poor patient survival. To investigate the association of enhanced E2F1 activity with aggressive phenotype, we performed a gene-specific silencing approach in a metastatic melanoma model. Knockdown of endogenous E2F1 via E2F1 small hairpin RNA (shRNA) expression increased E-cadherin expression of metastatic SK-Mel-147 melanoma cells and reduced their invasive potential but not their proliferative activity. Although growth rates of SK-Mel-147 and SK-Mel-103 xenograft tumors expressing E2F1 shRNA or control shRNA were similar, mice implanted with cells expressing E2F1 shRNA ... JNCI journals http://www.medworm.com/rss/comments.php?id=3186577 Tue, 19 Jan 2010 21:01:57 +0100 3186577 Importance of Age of Onset in Pancreatic Cancer Kindreds http://www.medworm.com/index.php?rid=3186576&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F2%2F119%3Frss%3D1 Conclusions Individuals with a family history of pancreatic cancer are at a statistically significantly increased risk of developing pancreatic cancer. Having a member of the family with a young-onset pancreatic cancer confers an added risk in FPC kindreds. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3186576 Tue, 19 Jan 2010 21:01:57 +0100 3186576 Paracrine Regulation of Pancreatic Cancer Cell Invasion by Peripheral Nerves http://www.medworm.com/index.php?rid=3186575&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F2%2F107%3Frss%3D1 Conclusion These data provide evidence for paracrine regulation of pancreatic cancer invasion by nerves, which may have important implications for potential therapy directed against nerve invasion by cancer. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3186575 Tue, 19 Jan 2010 21:01:57 +0100 3186575 Randomized Trial: Quitline Specialist Training in Gain-Framed vs Standard-Care Messages for Smoking Cessation http://www.medworm.com/index.php?rid=3186574&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F2%2F96%3Frss%3D1 Conclusions Quitline specialists can be trained to provide gain-framed counseling with good fidelity. Also, gain-framed messages appear to be somewhat more persuasive than standard-care messages in promoting early success in smoking cessation. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3186574 Tue, 19 Jan 2010 21:01:57 +0100 3186574 Protection From Right- and Left-Sided Colorectal Neoplasms After Colonoscopy: Population-Based Study http://www.medworm.com/index.php?rid=3186573&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F2%2F89%3Frss%3D1 Conclusion Prevalence of left-sided advanced colorectal neoplasms, but not right-sided advanced neoplasms, was strongly reduced within a 10-year period after colonoscopy, even in the community setting. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3186573 Tue, 19 Jan 2010 21:01:57 +0100 3186573 When is Cancer Care Cost-Effective? A Systematic Overview of Cost-Utility Analyses in Oncology http://www.medworm.com/index.php?rid=3186572&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F2%2F82%3Frss%3D1 We present league tables by disease categories that consist of a description of the intervention, its comparator, the target population, and the incremental cost-effectiveness ratio. The median reported incremental cost-effectiveness ratios (in 2008 US $) were $27 000 for breast cancer, $22 000 for colorectal cancer, $34 500 for prostate cancer, $32 000 for lung cancer, and $48 000 for hematologic cancers. The results highlight the many opportunities for efficient investment in cancer care across different cancer types and interventions and the many investments that are inefficient. Because we found only modest improvement in the quality of studies, we suggest that journals provide specific guidance for reporting CUA and assure that authors adhere to guidelines for conducting and reporting... JNCI journals http://www.medworm.com/rss/comments.php?id=3186572 Tue, 19 Jan 2010 21:01:57 +0100 3186572 Awards, Appointments, Announcements http://www.medworm.com/index.php?rid=3186571&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F2%2F81%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3186571 Tue, 19 Jan 2010 21:01:57 +0100 3186571 International Study of Hyperthermia Spurs Hope in U.S. Advocates http://www.medworm.com/index.php?rid=3186570&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F2%2F79%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3186570 Tue, 19 Jan 2010 21:01:56 +0100 3186570 New Data Cheer Champions of the Danger Theory http://www.medworm.com/index.php?rid=3186569&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F2%2F76%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3186569 Tue, 19 Jan 2010 21:01:56 +0100 3186569 StatBite: Radiation Therapy Plus Cetuximab: skin Reactions from 71 Head and Neck Cancer Patients from 11 Institutions in Europe http://www.medworm.com/index.php?rid=3186568&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F2%2F75%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3186568 Tue, 19 Jan 2010 21:01:56 +0100 3186568 Should Cetuximab Replace Cisplatin in Head and Neck Cancer? http://www.medworm.com/index.php?rid=3186567&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F2%2F74%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3186567 Tue, 19 Jan 2010 21:01:56 +0100 3186567 Increasing the Effectiveness of Tobacco Quitlines http://www.medworm.com/index.php?rid=3186566&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F2%2F72%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3186566 Tue, 19 Jan 2010 21:01:56 +0100 3186566 Is the Effectiveness of Colonoscopy "Good Enough" for Population-Based Screening? http://www.medworm.com/index.php?rid=3186565&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F2%2F70%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3186565 Tue, 19 Jan 2010 21:01:56 +0100 3186565 In this issue http://www.medworm.com/index.php?rid=3186564&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F2%2F69%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3186564 Tue, 19 Jan 2010 21:01:56 +0100 3186564 Table of Contents http://www.medworm.com/index.php?rid=3186563&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F2%2FNP-e%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3186563 Tue, 19 Jan 2010 21:01:56 +0100 3186563 Japanese journal of clinical oncology http://www.medworm.com/index.php?rid=3186562&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F2%2FNP-d%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3186562 Tue, 19 Jan 2010 21:01:56 +0100 3186562 Editorial board http://www.medworm.com/index.php?rid=3186561&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F2%2FNP-c%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3186561 Tue, 19 Jan 2010 21:01:56 +0100 3186561 Cover http://www.medworm.com/index.php?rid=3186560&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F2%2FNP-b%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3186560 Tue, 19 Jan 2010 21:01:56 +0100 3186560 Quitline Messages That Stress Benefits of Quitting May Improve Smoking Cessation http://www.medworm.com/index.php?rid=3186559&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F2%2FNP-a%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3186559 Tue, 19 Jan 2010 21:01:56 +0100 3186559 Fewer Left-Sided Colorectal Tumors Observed after Colonoscopies http://www.medworm.com/index.php?rid=3186558&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F2%2FNP%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3186558 Tue, 19 Jan 2010 21:01:56 +0100 3186558 DC-SCRIPT: Nuclear Receptor Modulation and Prognostic Significance in Primary Breast Cancer http://www.medworm.com/index.php?rid=3143583&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F1%2F54%3Frss%3D1 Conclusion DC-SCRIPT is a key regulator of nuclear receptor activity that has prognostic value in breast cancer. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3143583 Tue, 05 Jan 2010 21:01:46 +0100 3143583 Dermatologic Infections in Cancer Patients Treated With Epidermal Growth Factor Receptor Inhibitor Therapy http://www.medworm.com/index.php?rid=3143582&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F1%2F47%3Frss%3D1 Conclusions Patients with dermatologic toxic effects following treatment with EGFRIs have a high prevalence of cutaneous infections. Most notably, bacterial infections developed at sites previously affected by dermatologic toxic effects, with leukopenic patients being at greater risk. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3143582 Tue, 05 Jan 2010 21:01:46 +0100 3143582 Diabetes and Cardiovascular Disease During Androgen Deprivation Therapy: Observational Study of Veterans With Prostate Cancer http://www.medworm.com/index.php?rid=3143581&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F1%2F39%3Frss%3D1 Conclusion Androgen deprivation therapy with GnRH agonists was associated with an increased risk of diabetes and cardiovascular disease. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3143581 Tue, 05 Jan 2010 21:01:46 +0100 3143581 Assessing Lead Time of Selected Ovarian Cancer Biomarkers: A Nested Case-Control Study http://www.medworm.com/index.php?rid=3143580&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F1%2F26%3Frss%3D1 Conclusion Serum concentrations of CA125, HE4, and mesothelin may provide evidence of ovarian cancer 3 years before clinical diagnosis, but the likely lead time associated with these markers appears to be less than 1 year. (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3143580 Tue, 05 Jan 2010 21:01:46 +0100 3143580 Cardiotoxicity of Anticancer Drugs: The Need for Cardio-Oncology and Cardio-Oncological Prevention http://www.medworm.com/index.php?rid=3143579&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F1%2F14%3Frss%3D1 Due to the aging of the populations of developed countries and a common occurrence of risk factors, it is increasingly probable that a patient may have both cancer and cardiovascular disease. In addition, cytotoxic agents and targeted therapies used to treat cancer, including classic chemotherapeutic agents, monoclonal antibodies that target tyrosine kinase receptors, small molecule tyrosine kinase inhibitors, and even antiangiogenic drugs and chemoprevention agents such as cyclooxygenase-2 inhibitors, all affect the cardiovascular system. One of the reasons is that many agents reach targets in the microenvironment and do not affect only the tumor. Combination therapy often amplifies cardiotoxicity, and radiotherapy can also cause heart problems, particularly when combined with chemotherap... JNCI journals http://www.medworm.com/rss/comments.php?id=3143579 Tue, 05 Jan 2010 21:01:46 +0100 3143579 Awards, Appointments, Announcements http://www.medworm.com/index.php?rid=3143578&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F1%2F13%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3143578 Tue, 05 Jan 2010 21:01:46 +0100 3143578 Origin of Ovarian Cancer May Have Implications for Screening http://www.medworm.com/index.php?rid=3143577&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F1%2F11%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3143577 Tue, 05 Jan 2010 21:01:46 +0100 3143577 Mammography Screening: After the Storm, Calls for More Personalized Approaches http://www.medworm.com/index.php?rid=3143576&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F1%2F9%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3143576 Tue, 05 Jan 2010 21:01:46 +0100 3143576 StatBite: Relative Survival and Incidence Rates: Ductal Carcinoma In Situ http://www.medworm.com/index.php?rid=3143575&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F1%2F8%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3143575 Tue, 05 Jan 2010 21:01:46 +0100 3143575 Ductal Carcinoma In Situ: Should the Name Be Changed? http://www.medworm.com/index.php?rid=3143574&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F1%2F6%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3143574 Tue, 05 Jan 2010 21:01:46 +0100 3143574 Does the Benefit Justify the Risk? http://www.medworm.com/index.php?rid=3143573&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F1%2F4%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3143573 Tue, 05 Jan 2010 21:01:46 +0100 3143573 Designing Early Detection Programs for Ovarian Cancer http://www.medworm.com/index.php?rid=3143572&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F1%2F3%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3143572 Tue, 05 Jan 2010 21:01:46 +0100 3143572 In this issue http://www.medworm.com/index.php?rid=3143571&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F1%2F1%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3143571 Tue, 05 Jan 2010 21:01:46 +0100 3143571 Cover http://www.medworm.com/index.php?rid=3143570&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F1%2FNP-f%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3143570 Tue, 05 Jan 2010 21:01:46 +0100 3143570 Editorial board http://www.medworm.com/index.php?rid=3143569&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F1%2FNP-e%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3143569 Tue, 05 Jan 2010 21:01:45 +0100 3143569 Japanese journal of clinical oncology http://www.medworm.com/index.php?rid=3143568&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F1%2FNP-d%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3143568 Tue, 05 Jan 2010 21:01:45 +0100 3143568 Table of Contents http://www.medworm.com/index.php?rid=3143567&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F1%2FNP-c%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3143567 Tue, 05 Jan 2010 21:01:45 +0100 3143567 The Need for Cardio-Oncology: Treating Cancer and Protecting the Heart http://www.medworm.com/index.php?rid=3143566&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F1%2FNP-b%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3143566 Tue, 05 Jan 2010 21:01:45 +0100 3143566 Assessing Lead Time of Selected Ovarian Cancer Biomarkers http://www.medworm.com/index.php?rid=3143565&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F1%2FNP-a%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3143565 Tue, 05 Jan 2010 21:01:45 +0100 3143565 Higher Risk for Heart Disease and Diabetes Associated with Androgen Deprivation Therapy http://www.medworm.com/index.php?rid=3143564&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F102%2F1%2FNP%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3143564 Tue, 05 Jan 2010 21:01:45 +0100 3143564 Reviewers http://www.medworm.com/index.php?rid=3090118&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F101%2F24%2F1738%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3090118 Tue, 15 Dec 2009 21:01:46 +0100 3090118 Response: Re: Topoisomerase II Alpha and Responsiveness of Breast Cancer to Adjuvant Chemotherapy http://www.medworm.com/index.php?rid=3090117&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F101%2F24%2F1736%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3090117 Tue, 15 Dec 2009 21:01:46 +0100 3090117 Re: Topoisomerase II Alpha and Responsiveness of Breast Cancer to Adjuvant Chemotherapy http://www.medworm.com/index.php?rid=3090116&cid=s_31100_6_f&fid=31100&url=http%3A%2F%2Fjnci.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F101%2F24%2F1735%3Frss%3D1 (Source: JNCI) JNCI journals http://www.medworm.com/rss/comments.php?id=3090116 Tue, 15 Dec 2009 21:01:46 +0100 3090116