MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Japanese Journal of Clinical Oncology' source. Wed, 08 Feb 2012 08:41:37 +0100 http://www.medworm.com/index.php?rid=5646925&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F42%2F2%2F154%3Frss%3D1 (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5646925 Mon, 30 Jan 2012 05:00:00 +0100 5646925 http://www.medworm.com/index.php?rid=5646924&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F42%2F2%2F153%3Frss%3D1 (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5646924 Mon, 30 Jan 2012 05:00:00 +0100 5646924 http://www.medworm.com/index.php?rid=5646923&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F42%2F2%2F148%3Frss%3D1 In this study, expressions of five specific marker genes, namely, TFF1, TFF2, CK20, FABP1 and MUC2, were evaluated for their usefulness as markers of micro-dissemination. It was found that reverse transcriptase-polymerase chain reaction for these five genes yielded results highly specific for the depth of invasion and disease stage. Furthermore, the expression of CK20, FABP1 and MUC2 was a reliable prognostic indicator of peritoneal metastasis. Our results suggest that evaluation of the expression of CK20, FABP1 and MUC2 in peritoneal washings is a useful tool for identifying patients at high risk of peritoneal recurrence who may need adjuvant chemotherapy. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5646923 Mon, 30 Jan 2012 05:00:00 +0100 5646923 http://www.medworm.com/index.php?rid=5646922&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F42%2F2%2F139%3Frss%3D1 The Japan Cancer Surveillance Research Group estimated the cancer incidence in 2006 as part of the Monitoring of Cancer Incidence in Japan (MCIJ) project, on the basis of data collected from 15 of 32 population-based cancer registries. The total number of incidences in Japan for 2006 was estimated as 664 398 (C00–C96). The leading cancer site was stomach for men and breast for women. Age-standardized incidence rates remained at almost the same level as for the previous 3 years. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5646922 Mon, 30 Jan 2012 05:00:00 +0100 5646922 http://www.medworm.com/index.php?rid=5646921&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F42%2F2%2F134%3Frss%3D1 We planned a multicenter randomized phase III study to evaluate the efficacy of appropriate dose of bevacizumab (5 or 10 mg/kg) with FOLFIRI in patients with advanced/metastatic colorectal cancer who have failed prior bevacizumab plus oxaliplatin-based therapy. The primary endpoint is progression-free survival. The secondary endpoints are the toxicity, response rate, time to treatment failure, overall survival, overall survival from the start of the first-line treatment and second progression-free survival (time duration from the initiation of the first-line treatment until progression after the protocol treatment). A total of 370 patients were considered to be appropriate for this trial. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5646921 Mon, 30 Jan 2012 05:00:00 +0100 5646921 http://www.medworm.com/index.php?rid=5646920&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F42%2F2%2F131%3Frss%3D1 The standard treatment for T4 locally advanced gastric cancer is gastrectomy with D2 lymph node dissection followed by adjuvant chemotherapy with S-1 for 12 months; however, prognostic outcome in Stage IIIb has been insufficient. It is expected that survival is improved by preoperative treatment with a triplet regimen of docetaxel, cisplatin and S-1 (divided DCS therapy). A multicenter Phase II study has been conducted to evaluate the safety and efficacy of two courses of preoperative chemotherapy followed by gastrectomy. Fifty-five patients are required for this study. The primary endpoint of the study is pathological response rate of primary lesions. Secondary endpoints are overall survival, disease-free survival, R0 resection rate and adverse events. (Source: Japanese Journal of Clinica... Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5646920 Mon, 30 Jan 2012 05:00:00 +0100 5646920 http://www.medworm.com/index.php?rid=5646919&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F42%2F2%2F124%3Frss%3D1 Conclusions We conclude that breastfeeding possibly decreases the risk of breast cancer among Japanese women. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5646919 Mon, 30 Jan 2012 05:00:00 +0100 5646919 http://www.medworm.com/index.php?rid=5646918&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F42%2F2%2F120%3Frss%3D1 Two glioblastoma multiforme patients underwent 18F-FMISO (fluoromisonidazole) positron emission tomography study to access the tumor oxygenation status before and immediately after fractionated radiotherapy concomitant with temozolomide chemotherapy. In both cases, a prominent 18F-FMISO tumor accumulation observed in the first study was notably decreased in the second study, which was supposed to be a reoxygenation of the tumor. As far as we investigated, this is the first report of the changes of oxygenation status in glioblastoma multiforme treated through radiation therapy with temozolomide. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5646918 Mon, 30 Jan 2012 05:00:00 +0100 5646918 http://www.medworm.com/index.php?rid=5646917&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F42%2F2%2F113%3Frss%3D1 Conclusions The present study suggests that metastatic sites as well as primary kidney tumor respond to interferon-α-based immunotherapy in metastatic renal cell carcinoma patients with primary tumor in situ. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5646917 Mon, 30 Jan 2012 05:00:00 +0100 5646917 http://www.medworm.com/index.php?rid=5646916&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F42%2F2%2F105%3Frss%3D1 Conclusions The plasma levels of angiogenesis-related molecules were not elevated in patients with pancreatic cancer, compared with those with benign diseases or colorectal cancer. The plasma interleukin-8 level may be a novel biomarker for the response to chemotherapy in patients with pancreatic cancer and warrants further prospective study. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5646916 Mon, 30 Jan 2012 05:00:00 +0100 5646916 http://www.medworm.com/index.php?rid=5646915&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F42%2F2%2F96%3Frss%3D1 Conclusions The performance of the Japanese cancer screening program in 2009 was identified for the first time. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5646915 Mon, 30 Jan 2012 05:00:00 +0100 5646915 http://www.medworm.com/index.php?rid=5646914&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F42%2F2%2F85%3Frss%3D1 The Lymphoma Study Group (LSG) of the Japan Clinical Oncology Group (JCOG) was initiated in 1978 by five institutions and now has 47 members. JCOG-LSG has focused on combined modalities, dose intensification and the incorporation of new agents for major disease entities of lymphoid malignancies. More than 30 trials including 10 randomized trials have been conducted for aggressive non-Hodgkin's lymphoma (NHL), adult T-cell leukemia–lymphoma (ATL), lymphoblastic lymphoma/acute lymphoblastic leukemia, Hodgkin's lymphoma (HL), multiple myeloma, NK/T-NHL and indolent B-NHL, and correlative epidemiological and pathological studies have been performed on human T-lymphotropic virus type-I and T/B cell phenotypes. The first trials for aggressive NHL revealed significant differences in the pro... Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5646914 Mon, 30 Jan 2012 05:00:00 +0100 5646914 http://www.medworm.com/index.php?rid=5646913&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F42%2F2%2FNP%3Frss%3D1 (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5646913 Mon, 30 Jan 2012 05:00:00 +0100 5646913 http://www.medworm.com/index.php?rid=5537388&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F42%2F1%2F84%3Frss%3D1 (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5537388 Thu, 22 Dec 2011 05:00:00 +0100 5537388 http://www.medworm.com/index.php?rid=5537387&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F42%2F1%2F83%3Frss%3D1 (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5537387 Thu, 22 Dec 2011 05:00:00 +0100 5537387 http://www.medworm.com/index.php?rid=5537386&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F42%2F1%2F78%3Frss%3D1 In this report, we confirm the same mutation in his 66-year-old mother who had cecal cancer. PCR/direct sequencing analysis of peripheral blood lymphocytes revealed the same missense mutation in exon 12 at codon 600 of the MSH2 gene. The wave height of the capillary sequencer from the wild-type allele was decreased in tumor tissue, indicating loss of heterozygosity in the wild-type allele. Analysis of the tumor showed microsatellite instability high and loss of MSH2 protein expression. This sequence variant has not been reported in another family. This mutation is considered to play a significant and causative role in Lynch syndrome. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5537386 Thu, 22 Dec 2011 05:00:00 +0100 5537386 http://www.medworm.com/index.php?rid=5537385&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F42%2F1%2F74%3Frss%3D1 This randomized Phase II trial will compare the outcome of neoadjuvant chemotherapy using two and four courses of S-1 plus cisplatin or S-1 plus cisplatin plus docetaxel by a two-by-two factorial design for patients with macroscopically resectable serosa-positive gastric cancer. After neoadjuvant chemotherapy, patients will receive D2 gastrectomy followed by S-1 chemotherapy for 1 year postoperatively. The primary endpoint is the 3-year overall survival. The sample size is 120 for the two hypotheses: the superiority of four courses compared with two courses and the superiority of S-1 plus cisplatin plus docetaxel compared with S-1 plus cisplatin. This trial will be able to define the more suitable number of cycles and better regimen of neoadjuvant chemotherapy for gastric cancer. (Source: ... Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5537385 Thu, 22 Dec 2011 05:00:00 +0100 5537385 http://www.medworm.com/index.php?rid=5537384&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F42%2F1%2F63%3Frss%3D1 Conclusions We conclude that there is convincing evidence that cigarette smoking strongly increases the risk of esophageal cancer in the Japanese population. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5537384 Thu, 22 Dec 2011 05:00:00 +0100 5537384 http://www.medworm.com/index.php?rid=5537383&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F42%2F1%2F58%3Frss%3D1 We report a case of a locally recurrent rectal cancer that was successfully treated by total pelvic exenteration with combined ischiopubic rami resection. A 58-year-old male with locally recurrent rectal cancer and liver metastases was referred to our hospital. Computed tomography and magnetic resonance imaging showed a perineal tumor, which had invaded the prostate, urethra, and obturator internus muscle, and two liver metastases. Because the perineal tumor was very close to the dorsal vein complex and the pubic symphysis, it was considered difficult to approach and divide the dorsal vein complex, and still retain oncologic safety. To achieve R0 resection, total pelvic exenteration with ischiopubic rami resection, total emasculation and partial liver resection were performed. Pathological... Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5537383 Thu, 22 Dec 2011 05:00:00 +0100 5537383 http://www.medworm.com/index.php?rid=5537382&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F42%2F1%2F53%3Frss%3D1 Conclusions The results of the survey identified current patterns in the treatment planning and delivery processes of external-beam radiation therapy for prostate cancer in Japan. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5537382 Thu, 22 Dec 2011 05:00:00 +0100 5537382 http://www.medworm.com/index.php?rid=5537381&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F42%2F1%2F42%3Frss%3D1 Conclusions In Japan, most designated cancer hospitals with approved palliative care teams were more likely to integrate psychiatric consultation-liaison services into their palliative care programs. Systematic strategies for integration between palliative care and consultation-liaison psychiatry would contribute to the provision of appropriate psychosocial care for cancer patients and families at all stages. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5537381 Thu, 22 Dec 2011 05:00:00 +0100 5537381 http://www.medworm.com/index.php?rid=5537380&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F42%2F1%2F36%3Frss%3D1 Conclusions The human papillomavirus-16/18 AS04-adjuvanted vaccine was generally well tolerated and highly immunogenic when administered to young adolescent females and could be a promising tool for the prevention and control of cervical cancer in Bangladesh. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5537380 Thu, 22 Dec 2011 05:00:00 +0100 5537380 http://www.medworm.com/index.php?rid=5537379&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F42%2F1%2F29%3Frss%3D1 Conclusions The number of lymph nodes retrieved was shown to be an important prognostic variable not only in Stage II but also in Stage III colorectal cancer, and it was most prominently determined by the scope of nodal dissection. A cut-off value for the number of lymph nodes retrieved was not found, and it is necessary to carry out appropriate nodal dissection and examine as many lymph nodes as possible. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5537379 Thu, 22 Dec 2011 05:00:00 +0100 5537379 http://www.medworm.com/index.php?rid=5537378&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F42%2F1%2F21%3Frss%3D1 Conclusions The accuracy of cytological diagnosis at the facilities we surveyed was relatively high compared with the goals of assessment of diagnostic accuracy. However, the performance was dependent on the facility type, i.e. number of cases, staff involved and whether it was specialized or not, making the diagnosis specific for this region. We recommend that management of the accuracy of cytological diagnosis be undertaken jointly by multiple facilities to establish systems in Japan that lead to more useful diagnostic tools. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5537378 Thu, 22 Dec 2011 05:00:00 +0100 5537378 http://www.medworm.com/index.php?rid=5537377&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F42%2F1%2F14%3Frss%3D1 The Japanese Breast Cancer Study Group (JABCSG) was established before the Japan Clinical Oncology Group (JCOG). The JABCSG became the JCOG Breast Cancer Group 20 years ago. The first chairman of the Breast Cancer Group was Dr Kaoru Abe (National Cancer Center Hospital). Since 1978, five doctors have chaired the Breast Cancer Group. Sixteen clinical trials (eight phase III and eight phase I/II) have been conducted by the Breast Cancer Group since 1985. The Breast Cancer Group was restructured in 2010, and in June 2011 a new clinical trial (JCOG 1017) was initiated. Standard treatment for breast cancer (surgery, radiotherapy and systemic therapy) has changed dramatically over the last two decades. This review describes the transition of breast cancer treatment along with the history of JCOG... Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5537377 Thu, 22 Dec 2011 05:00:00 +0100 5537377 http://www.medworm.com/index.php?rid=5537376&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F42%2F1%2F2%3Frss%3D1 Conclusions Physical activity probably decreases the risk of colorectal cancer among the Japanese population. More specifically, the evidence for the colon is probable, whereas that for the rectum is insufficient. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5537376 Thu, 22 Dec 2011 05:00:00 +0100 5537376 http://www.medworm.com/index.php?rid=5537375&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F42%2F1%2F1%3Frss%3D1 (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5537375 Thu, 22 Dec 2011 05:00:00 +0100 5537375 http://www.medworm.com/index.php?rid=5537374&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F42%2F1%2FNP%3Frss%3D1 (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5537374 Thu, 22 Dec 2011 05:00:00 +0100 5537374 http://www.medworm.com/index.php?rid=5456856&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F12%2F1391%3Frss%3D1 (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5456856 Tue, 29 Nov 2011 05:00:00 +0100 5456856 http://www.medworm.com/index.php?rid=5456855&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F12%2F1390%3Frss%3D1 (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5456855 Tue, 29 Nov 2011 05:00:00 +0100 5456855 http://www.medworm.com/index.php?rid=5456854&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F12%2F1389%3Frss%3D1 (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5456854 Tue, 29 Nov 2011 05:00:00 +0100 5456854 http://www.medworm.com/index.php?rid=5456853&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F12%2F1388%3Frss%3D1 (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5456853 Tue, 29 Nov 2011 05:00:00 +0100 5456853 http://www.medworm.com/index.php?rid=5456852&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F12%2F1380%3Frss%3D1 Conclusions Continuous, once-daily administration of sunitinib was generally well tolerated in Turkish patients with advanced renal cell carcinoma in a daily practice setting. This study's response rates were comparable to those in previous randomized trials. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5456852 Tue, 29 Nov 2011 05:00:00 +0100 5456852 http://www.medworm.com/index.php?rid=5456851&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F12%2F1373%3Frss%3D1 Conclusions Induction chemoradiotherapy at 40 Gy in bladder-sparing protocols against MIBC is unlikely to increase the rate of severe complications of radical cystectomy. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5456851 Tue, 29 Nov 2011 05:00:00 +0100 5456851 http://www.medworm.com/index.php?rid=5456850&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F12%2F1366%3Frss%3D1 Conclusions Erlotinib has moderate efficacy for pretreated squamous cell carcinoma in Japanese patients. A higher grade of skin rash was associated with clinical benefit. Careful exclusion of pre-existing interstitial lung disease can minimize the occurrence of interstitial lung disease. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5456850 Tue, 29 Nov 2011 05:00:00 +0100 5456850 http://www.medworm.com/index.php?rid=5456849&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F12%2F1358%3Frss%3D1 Conclusions Liver resection is a valid option for the treatment of hepatocellular carcinoma in the elderly; major resections in cirrhotic old patients must be reserved for selected cases. Recurrence may be suitable of a radical approach, including surgery. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5456849 Tue, 29 Nov 2011 05:00:00 +0100 5456849 http://www.medworm.com/index.php?rid=5456848&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F12%2F1351%3Frss%3D1 Conclusions S-1 monotherapy shows promising signs of efficacy and tolerability in patients with recurrent or metastatic squamous cell carcinoma of the head and neck after failure of platinum-based chemotherapy in this retrospective cohort and warrants further investigation in this population. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5456848 Tue, 29 Nov 2011 05:00:00 +0100 5456848 http://www.medworm.com/index.php?rid=5456847&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F12%2F1344%3Frss%3D1 Conclusions We observed that period analysis demonstrates the most similar results to the actual observed survival and is, therefore, a useful method to derive precise cancer survival in gastric cancer. This information is useful to understand survival differences that are influenced by changing treatment strategy. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5456847 Tue, 29 Nov 2011 05:00:00 +0100 5456847 http://www.medworm.com/index.php?rid=5456846&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F12%2F1336%3Frss%3D1 Conclusions This is the largest population-based study with a homogeneous patient population focusing on oral cavity cancers within a high-incidence area. We found that oral cavity cancers are associated with an increased risk of nine second malignancies, which had a negative impact on survival. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5456846 Tue, 29 Nov 2011 05:00:00 +0100 5456846 http://www.medworm.com/index.php?rid=5456845&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F12%2F1327%3Frss%3D1 Conclusions This study demonstrated that histologic grade is highly correlated with some valuable biomarkers and confirmed the significance of histologic grade in Taiwanese female breast cancers. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5456845 Tue, 29 Nov 2011 05:00:00 +0100 5456845 http://www.medworm.com/index.php?rid=5456844&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F12%2F1322%3Frss%3D1 Conclusions This predictive factor could help to define a subgroup of patients who will be at a higher risk for axillary lymph node metastase and would benefit from additional close follow up or axillary lymph node dissection. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5456844 Tue, 29 Nov 2011 05:00:00 +0100 5456844 http://www.medworm.com/index.php?rid=5456843&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F12%2F1315%3Frss%3D1 Initially, Gastrointestinal Study Group in Japan Clinical Oncology Group (GIOSG/JCOG) focused on gastric cancer. In 1980s, fluoropyrimidine, cisplatin and mitomycin C were key drugs. A randomized Phase II trial (JCOG8501) comparing futrafur plus mitomycin C and uracil plus futrafur and mitomycin C showed a higher response rate of uracil plus futrafur and mitomycin C than futrafur plus mitomycin C. From the results of two Phase II trials of etoposide, adriamycin and cisplatin, and cisplatin plus 5-fluorouracil, uracil plus futrafur and mitomycin C and cisplatin plus 5-fluorouracil were adopted for the test arms of the Phase III trial (JCOG9205) comparing with continuous infusion of 5-fluorouracil as a control arm. Neither cisplatin plus 5-fluorouracil nor uracil plus futrafur and mitomycin ... Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5456843 Tue, 29 Nov 2011 05:00:00 +0100 5456843 http://www.medworm.com/index.php?rid=5456842&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F12%2FNP%3Frss%3D1 (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5456842 Tue, 29 Nov 2011 05:00:00 +0100 5456842 http://www.medworm.com/index.php?rid=5346794&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F11%2F1313%3Frss%3D1 (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5346794 Tue, 25 Oct 2011 04:00:00 +0100 5346794 http://www.medworm.com/index.php?rid=5346793&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F11%2F1312%3Frss%3D1 (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5346793 Tue, 25 Oct 2011 04:00:00 +0100 5346793 http://www.medworm.com/index.php?rid=5346792&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F11%2F1308%3Frss%3D1 A questionnaire survey was performed to investigate the actual hydration methods used with cisplatin-containing regimens at various institutions in Japan to gain an overview of the varieties employed. Replies were received from 368 of 686 institutions board-certified by the Japanese Respiratory Society. In 233 institutions (63%), new lung cancer patients were treated regularly with regimens containing cisplatin at ≥60 mg/m2. In 172 institutions (48%), hydration with <3000 ml of intravenous saline was performed on day 1. In 225 institutions (65%), hydration was performed for up to 3 days at most, but no more than 48 (14%) of the institutions that responded did so on day 1 only. Two to three weeks of hospitalization was needed for the initial course at most institutions (76%). Thirteen... Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5346792 Tue, 25 Oct 2011 04:00:00 +0100 5346792 http://www.medworm.com/index.php?rid=5346791&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F11%2F1303%3Frss%3D1 Bone marrow involvement in non-Hodgkin's lymphoma is prognostically important for appropriate management. Intrasinusoidal pattern of bone marrow infiltration is poorly identified on trephine biopsies. We analyzed the clinical, hematological and histopathological spectrum of eight cases of non-Hodgkin's lymphoma showing pure intrasinusoidal bone marrow infiltration. Fever, cytopenias and blasts in circulation were the indications for bone marrow aspiration and trephine biopsies. Flow cytometry on bone marrow and immunohistochemistry on trephine sections were done. There were five cases of T-cell hepatosplenic non-Hodgkin's lymphoma (three T-cell lymphoma) and three B-cell non-Hodgkin's lymphoma (two intravascular large B-cell lymphoma and one splenic marginal zone lymphoma). Except the case... Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5346791 Tue, 25 Oct 2011 04:00:00 +0100 5346791 http://www.medworm.com/index.php?rid=5346790&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F11%2F1292%3Frss%3D1 Conclusions We conclude that there is convincing evidence that cigarette smoking moderately increases the risk of pancreas cancer in the Japanese population. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5346790 Tue, 25 Oct 2011 04:00:00 +0100 5346790 http://www.medworm.com/index.php?rid=5346789&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F11%2F1287%3Frss%3D1 We report the first case of adrenocortical carcinoma secreting cortisol (Cushing's syndrome) and aldosterone (Conn's syndrome) with extensive distant metastasis at the time of diagnosis. A 72-year-old male with exertional dyspnea sought evaluation at our institution. The pattern of tumor spread (lung, pleura, bone and adrenal gland) and respiratory symptoms secondary to the tumor led clinicians to diagnose the primary tumor site as lung cancer and the adrenal mass as a metastatic site. However, endocrinologic studies and a biopsy revealed the primary site to be adrenocortical carcinoma. After histopathologic confirmation, the patient was treated with palliative chemotherapy, including mitotane, cisplatin, etoposide and doxorubicin. The patient died on the 14th day after chemotherapy of rap... Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5346789 Tue, 25 Oct 2011 04:00:00 +0100 5346789 http://www.medworm.com/index.php?rid=5346788&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F11%2F1282%3Frss%3D1 We report the case of a 50-year-old man with prostate cancer and renal allograft, who received radiotherapy after prostatectomy at the Institute of Radiotherapy of the University of Florence. Radiotherapy is part of the standard treatment for many cases of prostate cancer. According to the few series reported in the literature and also to our experience, radiation therapy is feasible also in renal transplant recipients with accurate treatment planning. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5346788 Tue, 25 Oct 2011 04:00:00 +0100 5346788 http://www.medworm.com/index.php?rid=5346787&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F11%2F1277%3Frss%3D1 We report the case of a patient with metastatic renal cell carcinoma with Xp11.2 translocation/transcription factor E3 (TFE3) gene fusion who had presented with sunitinib-induced nephrotic syndrome in association with favorable and durable treatment response. The nephrotic syndrome was managed successfully by discontinuing sunitinib and symptomatic treatment. The 27-year-old female patient presenting with right upper abdominal pain was diagnosed with Xp11.2 translocation renal cell carcinoma on the right side with multiple pulmonary and hepatic metastases. She underwent radical nephrectomy and took a daily dose of 37.5 mg sunitinib. Partial response to sunitinib was achieved and maintained for 5 months, but when nephrotic syndrome occurred, drug intake was discontinued. The nephrotic syndr... Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5346787 Tue, 25 Oct 2011 04:00:00 +0100 5346787 http://www.medworm.com/index.php?rid=5346786&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F11%2F1271%3Frss%3D1 Conclusions The results of our investigation showed that in Japanese patients treated at a single center, the PRIX score can accurately predict biochemical relapse after radical prostatectomy and demonstrates reasonable calibration. The PRIX score may be one option as a prediction model for biochemical relapse after radical prostatectomy. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5346786 Tue, 25 Oct 2011 04:00:00 +0100 5346786 http://www.medworm.com/index.php?rid=5346785&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F11%2F1265%3Frss%3D1 Conclusions Sorafenib was effective in Japanese patients with advanced renal cell carcinoma in general clinical practice and was tolerated although most patients required dose reduction or interruption of therapy. Future studies should establish new strategies for treatment without sacrificing both efficacy and patient quality of life. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5346785 Tue, 25 Oct 2011 04:00:00 +0100 5346785 http://www.medworm.com/index.php?rid=5346784&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F11%2F1259%3Frss%3D1 Conclusion The UCSF-CAPRA is an acceptable risk category tool comparable to that of the D'Amico risk classification for Japanese prostate cancer patients receiving radical prostatectomy in the contemporary Gleason grading era. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5346784 Tue, 25 Oct 2011 04:00:00 +0100 5346784 http://www.medworm.com/index.php?rid=5346783&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F11%2F1251%3Frss%3D1 Conclusions Oncologists' recognition may not accurately reflect their patients' supportive care needs and symptoms in usual care. Incorporation of a standard assessment system for supportive care needs and symptoms in clinical practice must heighten the oncologists' awareness of their patients' these problems. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5346783 Tue, 25 Oct 2011 04:00:00 +0100 5346783 http://www.medworm.com/index.php?rid=5346782&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F11%2F1244%3Frss%3D1 Conclusions Unplanned treatment for high-grade osteosarcoma can result in failure of local control and earlier systemic metastases. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5346782 Tue, 25 Oct 2011 04:00:00 +0100 5346782 http://www.medworm.com/index.php?rid=5346781&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F11%2F1241%3Frss%3D1 The Radiation Therapy Study Group (RTSG) of the Japan Clinical Oncology Group (JCOG) was established in 2003. The missions of this group are to develop new standards of care with innovative, advanced technology radiation therapy, both for single- and multi-modality cancer treatment, and to improve radiation therapy quality and outcomes of JCOG trials conducted by other organ-oriented groups. In 2004, the first RTSG trial, a Phase II study of stereotactic body radiation therapy for Stage IA non-small cell lung cancer (JCOG 0403), was initiated. Four other trials are currently open for accrual. JCOG 0702 is a Phase I study of stereotactic body radiation therapy in patients with T2N0M0 non-small cell lung cancer. JCOG 0701 is a Phase III study comparing accelerated fractionation with conventi... Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5346781 Tue, 25 Oct 2011 04:00:00 +0100 5346781 http://www.medworm.com/index.php?rid=5346780&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F11%2FNP%3Frss%3D1 (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5346780 Tue, 25 Oct 2011 04:00:00 +0100 5346780 http://www.medworm.com/index.php?rid=5260041&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F10%2F1240%3Frss%3D1 (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5260041 Wed, 28 Sep 2011 04:00:00 +0100 5260041 http://www.medworm.com/index.php?rid=5260040&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F10%2F1238%3Frss%3D1 (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5260040 Wed, 28 Sep 2011 04:00:00 +0100 5260040 http://www.medworm.com/index.php?rid=5260039&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F10%2F1233%3Frss%3D1 Previous studies have reported the existence of an association between brain-derived neurotrophic factor and major depression. However, the possible role of brain-derived neurotrophic factor in the pathophysiology of major depression after cancer diagnosis has not yet been investigated. Subjects were collected using the Lung Cancer Database project. Using the cut-off scores on the depression subscale of the Hospital Anxiety and Depression Scale (HADS-D), 81 subjects with depression (HADS-D > 10) and 81 subjects without depression (HADS-D < 5) were selected. The two groups were matched for age, sex, clinical stage and performance status. The serum brain-derived neurotrophic factor levels were measured using an enzyme-linked immunosorbent assay method. The serum brain-derived neurotrop... Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5260039 Wed, 28 Sep 2011 04:00:00 +0100 5260039 http://www.medworm.com/index.php?rid=5260038&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F10%2F1229%3Frss%3D1 Recently, in patients with unresectable colorectal liver metastasis, liver resection sometimes becomes possible by intensive systemic chemotherapy, i.e. conversion therapy. However, among cases that do not respond well to first-line chemotherapy, it is rare that second-line chemotherapy results in a marked response allowing liver resection. We consider that the liver resection rate may be increased by initiating second-line treatment at an earlier stage before progression subsequent to first-line chemotherapy. We are conducting a multicentre Phase II study to evaluate the efficacy and safety of sequential chemotherapy using six cycles of cetuximab plus FOLFIRI (5-fluorouracil, folinic acid and irinotecan) followed by six cycles of bevacizumab plus FOLFOX (5-fluorouracil, folinic acid and o... Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5260038 Wed, 28 Sep 2011 04:00:00 +0100 5260038 http://www.medworm.com/index.php?rid=5260037&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F10%2F1225%3Frss%3D1 We describe here three patients with colorectal cancer who developed pneumatosis intestinalis during treatment with cetuximab-containing chemotherapy, which developed after 7, 19 and 47 weeks of cetuximab treatment, and discovered on routine follow-up computed tomographic scans for response evaluations. None of these patients complained of abdominal pain, showed signs of peritoneal irritation on physical examination or had elevated serum concentrations of acute inflammatory markers. Following cessation of cetuximab and conservative medical treatment, all three patients showed complete resolution of pneumatosis intestinalis on abdominal pelvic computed tomographic scans. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5260037 Wed, 28 Sep 2011 04:00:00 +0100 5260037 http://www.medworm.com/index.php?rid=5260036&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F10%2F1221%3Frss%3D1 Polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes syndrome is a rare multi-systematic disorder of uncertain etiology, if associated with multicentric Castleman's disease, it can lead to a more serious condition. We here presented a case of polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes syndrome in a 37-year-old male patient who initially presented with progressive lower limb weakness accompanied by pain, low skin temperature, and hyperpigmentation. He was admitted with increasingly serious dyspnea and lower leg edema. Fluid of serous cavities in the patient were also indicated in ultrasonic inspection and X-ray. Furthermore, biopsy of a left axillary lymph node showed mixed hyaline-vascular and plasma cell type of multicentric Castleman's di... Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5260036 Wed, 28 Sep 2011 04:00:00 +0100 5260036 http://www.medworm.com/index.php?rid=5260035&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F10%2F1214%3Frss%3D1 Conclusions Gemcitabine and paclitaxel chemotherapy had favorable benefit and safety profiles, and the regimen is recommended as a potential second-line chemotherapy for advanced or metastatic urothelial carcinoma previously treated with methotrexate, vinblastine, doxorubicin and cisplatin chemotherapy. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5260035 Wed, 28 Sep 2011 04:00:00 +0100 5260035 http://www.medworm.com/index.php?rid=5260034&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F10%2F1209%3Frss%3D1 Conclusions The incidences of bone metastases in patients with a prostate-specific antigen level of ≤20 ng/ml and Gleason score of ≤6 were reasonably low. Collectively, a bone scan is not necessary as a routine examination for these patients at their initial staging of prostate cancer. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5260034 Wed, 28 Sep 2011 04:00:00 +0100 5260034 http://www.medworm.com/index.php?rid=5260033&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F10%2F1203%3Frss%3D1 Conclusions Oncology market research is a useful tool for evaluating standardization of colorectal cancer chemotherapy. Furthermore, we expect that this method will contribute to the development of more effective cancer therapies. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5260033 Wed, 28 Sep 2011 04:00:00 +0100 5260033 http://www.medworm.com/index.php?rid=5260032&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F10%2F1194%3Frss%3D1 Conclusions These results confirm the possible clinical utility of pfetin as a prognostic biomarker for gastrointestinal stromal tumor. Pfetin appears to be a novel clinically applicable prognostic factor, which may be useful for deciding whether to administer imatinib mesylate or not. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5260032 Wed, 28 Sep 2011 04:00:00 +0100 5260032 http://www.medworm.com/index.php?rid=5260031&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F10%2F1182%3Frss%3D1 Conclusions Methotrexate–cisplatin–fluorouracil induction chemotherapy followed by weekly cisplatin–fluorouracil concurrent chemoradiation is an acute and late toxicity-acceptable protocol without attenuating organ preservation survival in patients with locoregionally advanced head and neck squamous cell carcinoma. In this patient cohort with advanced head and neck squamous cell carcinoma, overall and organ preservation survivals were encouraging, and provided promising long-term benefits of this approach. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5260031 Wed, 28 Sep 2011 04:00:00 +0100 5260031 http://www.medworm.com/index.php?rid=5260030&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F10%2F1177%3Frss%3D1 Conclusion The use of endobronchial ultrasonography guide sheath allows a reduction in fluoroscopy time and may reduce the adverse effects of radiation exposure on patients and staff. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5260030 Wed, 28 Sep 2011 04:00:00 +0100 5260030 http://www.medworm.com/index.php?rid=5260029&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F10%2F1168%3Frss%3D1 Conclusions Our study shows that in Indonesian cancer patients treated with highly cytostatic emetogenic, carriership of the CTG haplotype of the ABCB1 gene is related to an increased risk of delayed chemotherapy-induced nausea and vomiting. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5260029 Wed, 28 Sep 2011 04:00:00 +0100 5260029 http://www.medworm.com/index.php?rid=5260028&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F10%2F1162%3Frss%3D1 Conclusions A significant rate of axillary metastases occurred in the patients with T1mi breast carcinoma in this study. The comedo subtype of ductal carcinoma in situ, a high histologic grade, the presence of necrosis and the Van Nuys group 3 were significant predictors of axillary lymph node metastasis in patients with T1mi breast cancer. Thus, the patients with T1mi breast disease are indicated to a careful evaluation of axillary lymph node metastasis, if they have the earlier-mentioned unfavorable factors. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5260028 Wed, 28 Sep 2011 04:00:00 +0100 5260028 http://www.medworm.com/index.php?rid=5260027&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F10%2F1156%3Frss%3D1 The Gynecologic Cancer Study Group (GCSG) of the Japan Clinical Oncology Group (JCOG) was organized in 1994. The GCSG has developed under the leadership of three successive group representatives, five principal study investigators, the cooperation of group members and the support of several public research funds. At present, 38 institutions are participating as active members of the GCSG of the JCOG. In addition to gynecologic oncologists, medical oncologists, pathologists and radiotherapists are participating in our group. Our group manages female genital malignancies including uterine cervical, endometrial, ovarian, tubal and vulvar cancers. Because the incidences of uterine cervical (in younger women), endometrial and ovarian cancer have increased in Japan in recent years, we are develo... Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5260027 Wed, 28 Sep 2011 04:00:00 +0100 5260027 http://www.medworm.com/index.php?rid=5260026&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F10%2F1155%3Frss%3D1 (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5260026 Wed, 28 Sep 2011 04:00:00 +0100 5260026 http://www.medworm.com/index.php?rid=5260025&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F10%2FNP%3Frss%3D1 (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5260025 Wed, 28 Sep 2011 04:00:00 +0100 5260025 http://www.medworm.com/index.php?rid=5175399&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F9%2F1153%3Frss%3D1 (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5175399 Sun, 28 Aug 2011 23:00:00 +0100 5175399 http://www.medworm.com/index.php?rid=5175398&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F9%2F1152%3Frss%3D1 (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5175398 Sun, 28 Aug 2011 23:00:00 +0100 5175398 http://www.medworm.com/index.php?rid=5175397&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F9%2F1147%3Frss%3D1 The aim of this study was to establish the discriminating accuracy of Kanao's pre-operative nomogram for renal cell carcinoma in predicting cause-specific survival among representative patients who underwent nephrectomy. Patients originated from two centers: Chiba University Hospital (n= 151) and Chiba Cancer Center (n = 91). We validated the predictive accuracy, which was assessed using Harrell's concordance-index. The concordance-index values were 0.692 and 0.834 for Chiba University Hospital and Chiba Cancer Center, respectively, although it was 0.822 for the combined data sets. Results of external validation were different at each cohort. We constructed calibration plots of Kanao's nomogram and confirmed the tendency at each institution. Inconsistency of results among two centers makes... Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5175397 Sun, 28 Aug 2011 23:00:00 +0100 5175397 http://www.medworm.com/index.php?rid=5175396&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F9%2F1142%3Frss%3D1 We report a case of 40-year-old man presented with classical manifestations of primary hyperparathyroidism, severe hypercalcemia and profoundly increased serum parathyroid hormone level. Neck ultrasonography demonstrated multinodular goiter with predominant 34 mm nodule in left thyroid lobe. Additional 16 mm nodule was found beneath the left lobe. Routine percutaneous fine-needle aspiration of predominant nodule indicated follicular thyroid carcinoma, while left inferior nodule was confirmed to be of parathyroid origin. The patient underwent surgery, during which frozen sections identified medullary thyroid carcinoma with metastasis to upper mediastinal lymph node. Permanent sections of the predominant left lobe nodule revealed intrathyroidal parathyroid carcinoma surrounded with multiple ... Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5175396 Sun, 28 Aug 2011 23:00:00 +0100 5175396 http://www.medworm.com/index.php?rid=5175395&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F9%2F1138%3Frss%3D1 We describe the case of a 72-year-old woman with locally advanced lung tumor mimicking primary lung cancer. She was diagnosed with rectal cancer at the age of 65 years and was initially treated with platinum-based chemotherapy and thoracic irradiation as a treatment for primary lung cancer. One year later, a thyroid tumor was detected in her right thyroid lobe and was confirmed to have metastasized from rectal cancer based on pathological findings. Therefore, we suspected that she had metachronous double cancers and treated her with conventional chemotherapy for colorectal cancer. However, new life-threatening multiple lung metastases appeared. We treated her with the drug erlotinib because additional genetic analysis against primary lung tumor revealed typical double-activating epidermal ... Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5175395 Sun, 28 Aug 2011 23:00:00 +0100 5175395 http://www.medworm.com/index.php?rid=5175394&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F9%2F1132%3Frss%3D1 Conclusions The relatively high frequency of LKB1 mutations in mucinous bronchioloalveolar carcinoma patients may therefore suggest its involvement in lung carcinogenesis, at least in mucinous bronchioloalveolar carcinoma. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5175394 Sun, 28 Aug 2011 23:00:00 +0100 5175394 http://www.medworm.com/index.php?rid=5175393&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F9%2F1127%3Frss%3D1 Conclusions The quantity of the cold spots caused by the geometrical uncertainties in field-in-field techniques was similar to that for the wedge techniques and was acceptable. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5175393 Sun, 28 Aug 2011 23:00:00 +0100 5175393 http://www.medworm.com/index.php?rid=5175392&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F9%2F1119%3Frss%3D1 Conclusions A consensus-based guideline defining the clinical target volume primary was developed for external beam radiotherapy for intact uterine cervical cancer. This guideline will serve as a template for radiotherapy protocols in future clinical trials. It may also be used in actual clinical practice in the setting of highly precise external beam radiotherapy, including intensity-modulated radiotherapy. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5175392 Sun, 28 Aug 2011 23:00:00 +0100 5175392 http://www.medworm.com/index.php?rid=5175391&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F9%2F1112%3Frss%3D1 Conclusions The results indicated that qualitative and subjective factors (i.e. the degrees of importance of and satisfaction with roles) are associated more closely with emotional states and role functional quality of life in breast cancer outpatients than quantitative and objective factors (i.e. degree of role accomplishment and the number of roles). (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5175391 Sun, 28 Aug 2011 23:00:00 +0100 5175391 http://www.medworm.com/index.php?rid=5175390&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F9%2F1101%3Frss%3D1 Conclusions It was reconfirmed that the incidences of serious leukopenia, thrombocytopenia and diarrhea were high among the patients with contraindication or careful administration of its use prescribed in the drug package insert. Therefore, for proper use of irinotecan, it is important to discriminate the patient on the basis of risk status. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5175390 Sun, 28 Aug 2011 23:00:00 +0100 5175390 http://www.medworm.com/index.php?rid=5175389&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F9%2F1094%3Frss%3D1 Conclusions Primary dedifferentiated liposarcoma in the extremities predominantly occurred in the thigh and a rapid enlargement of long-standing tumors was a characteristic symptom. Although the local behavior of these tumors was less aggressive than that of retroperitoneal dedifferentiated liposarcomas, they had a relatively high metastatic potential. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5175389 Sun, 28 Aug 2011 23:00:00 +0100 5175389 http://www.medworm.com/index.php?rid=5175388&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F9%2F1086%3Frss%3D1 Conclusions A subset of gallbladder carcinoma cases revealed the overexpression of matrix metalloprotease-1 and protease-activated receptor-1, which was associated with a progressive pathological feature and an aggressive clinical course. Therefore, matrix metalloprotease-1 and protease-activated receptor-1 expressions may be predictors for a poor prognosis in patients with gallbladder carcinoma. This is the first report describing about the involvement of matrix metalloprotease-1 and protease-activated receptor-1 axis in gallbladder carcinoma. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5175388 Sun, 28 Aug 2011 23:00:00 +0100 5175388 http://www.medworm.com/index.php?rid=5175387&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F9%2F1079%3Frss%3D1 Conclusions Multicentric adenocarcinomas of the biliary tract have distinct features compared with single cancers. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5175387 Sun, 28 Aug 2011 23:00:00 +0100 5175387 http://www.medworm.com/index.php?rid=5175386&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F9%2F1074%3Frss%3D1 Conclusions Our new chemoradiotherapy is effective for loco-regional control of anaplastic thyroid carcinoma, particularly when combined with radical surgery. This regimen could not prevent distant metastases, but offers acceptable toxicity while maintaining patient quality of life. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5175386 Sun, 28 Aug 2011 23:00:00 +0100 5175386 http://www.medworm.com/index.php?rid=5175385&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F9%2F1067%3Frss%3D1 Conclusions The study supports the enrollment of Japanese patients in the Phase III study (ATTRACT-2) of ASA404 in combination with docetaxel for the second-line treatment of advanced non-small cell lung cancer. Clinicaltrials.gov identifier: NCT01285453 (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5175385 Sun, 28 Aug 2011 23:00:00 +0100 5175385 http://www.medworm.com/index.php?rid=5175384&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F9%2F1059%3Frss%3D1 Conclusions Pre-emptive use of lamivudine seems to reduce the degree of alanine aminotransferase abnormality and the incidence of hepatitis flare-up. Age (≥55) at initiation of adjuvant chemotherapy was an independently associated factor. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5175384 Sun, 28 Aug 2011 23:00:00 +0100 5175384 http://www.medworm.com/index.php?rid=5175383&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F9%2F1051%3Frss%3D1 Conclusions Monotherapy with S-1 or combination therapy with S-1 + trastuzumab was well tolerated for inoperable or recurrent breast cancer patients. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5175383 Sun, 28 Aug 2011 23:00:00 +0100 5175383 http://www.medworm.com/index.php?rid=5175382&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F9%2F1049%3Frss%3D1 (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5175382 Sun, 28 Aug 2011 23:00:00 +0100 5175382 http://www.medworm.com/index.php?rid=5175381&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F9%2FNP%3Frss%3D1 (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5175381 Sun, 28 Aug 2011 23:00:00 +0100 5175381 http://www.medworm.com/index.php?rid=5078513&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F8%2F1046%3Frss%3D1 (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5078513 Thu, 28 Jul 2011 23:00:00 +0100 5078513 http://www.medworm.com/index.php?rid=5078512&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F8%2F1045%3Frss%3D1 (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5078512 Thu, 28 Jul 2011 23:00:00 +0100 5078512 http://www.medworm.com/index.php?rid=5078511&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F8%2F1041%3Frss%3D1 In Western countries, the standard treatment for locally advanced rectal cancer is preoperative chemoradiotherapy followed by total mesorectal excision. On the other hand, in Japan, treatment results without radiotherapy are by no means inferior; therefore, extrapolation of results of preoperative treatment in Western countries to Japan is controversial. We consider that survival may be improved by preoperative treatment with new anticancer agents as they are expected not only to decrease the local recurrence rate but also to prevent distant metastases. We are conducting a multicentre Phase II study to evaluate the safety and efficacy of neoadjuvant chemotherapy using XELOX plus bevacizumab without radiotherapy in patients with locally advanced rectal cancer. The primary endpoint of the st... Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5078511 Thu, 28 Jul 2011 23:00:00 +0100 5078511 http://www.medworm.com/index.php?rid=5078510&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F8%2F1037%3Frss%3D1 We report the second case of an adult nephroblastoma that arose within the primary testicular teratoma in a non-atrophic testis. Teratoma and nephroblastoma within the same testis may have an important point to clarify the developmental mechanism in nephroblastomatous differentiation of germ cell tumors. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5078510 Thu, 28 Jul 2011 23:00:00 +0100 5078510 http://www.medworm.com/index.php?rid=5078509&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F8%2F1031%3Frss%3D1 Conclusions Salvage radiotherapy was effective for prostate-specific antigen relapse after radical prostatectomy with tolerable toxicities in Japanese patients. A high Gleason score seemed to be a poor prognostic factor. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5078509 Thu, 28 Jul 2011 23:00:00 +0100 5078509 http://www.medworm.com/index.php?rid=5078508&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F8%2F1023%3Frss%3D1 Conclusions Combination immunotherapy with low-dose interleukin-2 plus interferon-α showed survival benefit for patients with lung metastasis whose tumor responded as no change or better. This combination immunotherapy could be beneficial for patients selected by metastatic organ and their pre-treatment serum sodium level. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5078508 Thu, 28 Jul 2011 23:00:00 +0100 5078508 http://www.medworm.com/index.php?rid=5078507&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F8%2F1017%3Frss%3D1 Conclusions Direct surgical resection of highly suspicious pulmonary nodules can be a valid procedure. However, careful patient selection and further investigations are required to justify direct surgical resection. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5078507 Thu, 28 Jul 2011 23:00:00 +0100 5078507 http://www.medworm.com/index.php?rid=5078506&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F8%2F1013%3Frss%3D1 Conclusions Combination therapy with carboplatin and paclitaxel yielded an objective response in about one-third of the patients with advanced thymic carcinoma. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5078506 Thu, 28 Jul 2011 23:00:00 +0100 5078506 http://www.medworm.com/index.php?rid=5078505&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F8%2F1007%3Frss%3D1 Conclusions Involved field radiotherapy did not result in significant incidence of regional lymph node failure in clinical stage I thoracic esophageal cancer patients. However, further investigation is needed to establish the optimal radiotherapy field for clinical stage I thoracic esophageal cancer. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5078505 Thu, 28 Jul 2011 23:00:00 +0100 5078505 http://www.medworm.com/index.php?rid=5078504&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F8%2F999%3Frss%3D1 Conclusions Many oncologists reported high levels of burden relating to communication of discontinuation of anticancer treatment. A specific communication skills training program, sufficient time for communication and development of a multidisciplinary model could help alleviate the burden on oncologists. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5078504 Thu, 28 Jul 2011 23:00:00 +0100 5078504 http://www.medworm.com/index.php?rid=5078503&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F8%2F992%3Frss%3D1 Conclusions Radical resection might result in a reasonable prognosis for gallbladder cancer patients with local metastasis of the lymph nodes (Japanese Society of Biliary Surgery N1–N2), but was not effective when distant lymph nodes (Japanese Society of Biliary Surgery N3) were involved. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5078503 Thu, 28 Jul 2011 23:00:00 +0100 5078503 http://www.medworm.com/index.php?rid=5078502&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F8%2F987%3Frss%3D1 Conclusions The positive Delphian node is exclusively encountered in advanced laryngeal cancers and suggests an ominous outcome. Sufficient dissection of the paratracheal and lateral neck nodes is recommended. Delphian node evaluation is advised for all supracricoid laryngectomy surgeries. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5078502 Thu, 28 Jul 2011 23:00:00 +0100 5078502 http://www.medworm.com/index.php?rid=5078501&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F8%2F980%3Frss%3D1 Conclusions Weekly cisplatin could be easier to manage than three-weekly cisplatin, because patients can be monitored more regularly for toxicity allowing the schedule to be altered if required. This regimen appears to be a suitable alternative to three-weekly high-dose cisplatin with concomitant radiotherapy. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5078501 Thu, 28 Jul 2011 23:00:00 +0100 5078501 http://www.medworm.com/index.php?rid=5078500&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F8%2F973%3Frss%3D1 Conclusions The treatment completion rate by this protocol was low in head and neck cancer patients even when the cisplatin dose was reduced to 80 mg/m2. This tendency was seen in patients with a low serum albumin level. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5078500 Thu, 28 Jul 2011 23:00:00 +0100 5078500 http://www.medworm.com/index.php?rid=5078499&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F8%2F964%3Frss%3D1 Conclusions Palliative chemoradiotherapy using 5-fluorouracil plus cisplatin combined with concurrent 40 Gy irradiation effectively improved the symptom of dysphagia in Stage IVB esophageal cancer with acceptable toxicity and favorable survival. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5078499 Thu, 28 Jul 2011 23:00:00 +0100 5078499 http://www.medworm.com/index.php?rid=5078498&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F8%2F959%3Frss%3D1 Conclusions Erlotinib as third-line therapy showed an acceptable response rate, survival time and toxicity. It could be a potential third-line therapy for patients without epidermal growth factor receptor mutations. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5078498 Thu, 28 Jul 2011 23:00:00 +0100 5078498 http://www.medworm.com/index.php?rid=5078497&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F8%2F953%3Frss%3D1 Conclusions Gemcitabine and S-1 combination therapy produced a high response rate with good survival in patients with metastatic pancreatic cancer. A randomized Phase III study to confirm the efficacy of gemcitabine and S-1 combination therapy is ongoing. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5078497 Thu, 28 Jul 2011 23:00:00 +0100 5078497 http://www.medworm.com/index.php?rid=5078496&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F8%2F948%3Frss%3D1 Conclusions Gefitinib as a first-line therapy is active and well tolerated in elderly patients with pulmonary adenocarcinoma, especially in those who have never smoked. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5078496 Thu, 28 Jul 2011 23:00:00 +0100 5078496 http://www.medworm.com/index.php?rid=5078495&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F8%2F937%3Frss%3D1 Oncology research has traditionally been conducted using techniques from the biological sciences. The new field of computational oncology has forged a new relationship between the physical sciences and oncology to further advance research. By applying physics and mathematics to oncologic problems, new insights will emerge into the pathogenesis and treatment of malignancies. One major area of investigation in computational oncology centers around the acquisition and analysis of data, using improved computing hardware and software. Large databases of cellular pathways are being analyzed to understand the interrelationship among complex biological processes. Computer-aided detection is being applied to the analysis of routine imaging data including mammography and chest imaging to improve the... Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5078495 Thu, 28 Jul 2011 23:00:00 +0100 5078495 http://www.medworm.com/index.php?rid=5078494&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F8%2F935%3Frss%3D1 (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5078494 Thu, 28 Jul 2011 23:00:00 +0100 5078494 http://www.medworm.com/index.php?rid=5078493&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F8%2FNP%3Frss%3D1 (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5078493 Thu, 28 Jul 2011 23:00:00 +0100 5078493 http://www.medworm.com/index.php?rid=4985421&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F7%2F932%3Frss%3D1 (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=4985421 Wed, 29 Jun 2011 23:00:00 +0100 4985421 http://www.medworm.com/index.php?rid=4985420&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F7%2F931%3Frss%3D1 (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=4985420 Wed, 29 Jun 2011 23:00:00 +0100 4985420 http://www.medworm.com/index.php?rid=4985419&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F7%2F924%3Frss%3D1 The 20th Hiroshima Cancer seminar focused upon breast cancer research and treatment particularly on the mechanism of tumorigenesis and drug resistance and development of novel therapeutics. Several molecules such as retinoblastoma and p16 were raised as key factors in tumorigenesis and invasiveness. Estrogen-related pathways seem to be closely involved in the process. For the tumor lacking hormone receptor and human epidermal growth factor 2, some other mechanisms could be responsible. It seems that MicroRNA 22 directing some putative targets such as SIRT1, Sp1 and CDK6 plays a crucial role in breast tumor growth and metastasis. In addition, ribophorin and the associated molecules might be engaged in breast cancer stemness. Obviously, these molecules provide potential for therapeutic targe... Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=4985419 Wed, 29 Jun 2011 23:00:00 +0100 4985419 http://www.medworm.com/index.php?rid=4985418&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F7%2F918%3Frss%3D1 We present this case to increase awareness of this entity and stress the need for histological evaluation of some breast masses. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=4985418 Wed, 29 Jun 2011 23:00:00 +0100 4985418 http://www.medworm.com/index.php?rid=4985417&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F7%2F915%3Frss%3D1 We report a case of spontaneous regression of pulmonary metastases from a malignant phyllodes tumor. A 50-year-old woman was diagnosed with a breast phyllodes tumor. Computed tomography and positron emission tomography revealed multiple lung metastases. She underwent a mastectomy to control the pain of the enlarging breast mass. Histopathologic examination diagnosed a malignant phyllodes tumor. Without the administration of any adjuvant therapy, the follow-up chest computed tomography scan and positron emission tomography scan showed disappearance of the lung metastases 2 months after surgery. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=4985417 Wed, 29 Jun 2011 23:00:00 +0100 4985417 http://www.medworm.com/index.php?rid=4985416&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F7%2F908%3Frss%3D1 Conclusions The rate of downstaging by neoadjuvant gemcitabine plus cisplatin was comparable with that by methotrexate, vinblastine, doxorubicin and cisplatin. Gemcitabine plus cisplatin was associated with less non-hematologic toxicity than methotrexate, vinblastine, doxorubicin and cisplatin. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=4985416 Wed, 29 Jun 2011 23:00:00 +0100 4985416 http://www.medworm.com/index.php?rid=4985415&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F7%2F902%3Frss%3D1 Conclusion Cases with a primary cT2 tumor could be good candidates for BPT with radiation combined with cisplatin. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=4985415 Wed, 29 Jun 2011 23:00:00 +0100 4985415 http://www.medworm.com/index.php?rid=4985414&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F7%2F897%3Frss%3D1 Conclusion Amrubicin was potentially active against previously treated large-cell neuroendocrine carcinoma. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=4985414 Wed, 29 Jun 2011 23:00:00 +0100 4985414 http://www.medworm.com/index.php?rid=4985413&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F7%2F890%3Frss%3D1 Conclusions Maximum standardized uptake value of the primary tumor was a powerful prognostic determinant for patients with adenocarcinoma, but not with squamous cell carcinoma of the lung. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=4985413 Wed, 29 Jun 2011 23:00:00 +0100 4985413 http://www.medworm.com/index.php?rid=4985412&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F7%2F882%3Frss%3D1 Conclusions Helical tomotherapy achieved the best tumor coverage of the remaining normal liver. However, helical tomotherapy showed much exposure to the remaining liver at the lower dose region and left kidney. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=4985412 Wed, 29 Jun 2011 23:00:00 +0100 4985412 http://www.medworm.com/index.php?rid=4985411&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F7%2F876%3Frss%3D1 Conclusions Continuous prophylaxis by oral 200 mg/day acyclovir in multiple myeloma patients receiving bortezomib treatment is effective and sufficient in preventing herpes zoster. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=4985411 Wed, 29 Jun 2011 23:00:00 +0100 4985411 http://www.medworm.com/index.php?rid=4985410&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F7%2F867%3Frss%3D1 Conclusions Eight cycles of neoadjuvant chemotherapy—docetaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide—are tolerable and conferred high rates of pathological complete response and breast-conserving surgery. Patients with triple-negative disease were more likely to achieve pathological complete response versus other subtypes, suggesting that selecting appropriate neoadjuvant chemotherapy based on molecular subtype could be possible. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=4985410 Wed, 29 Jun 2011 23:00:00 +0100 4985410 http://www.medworm.com/index.php?rid=4985409&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F7%2F854%3Frss%3D1 Conclusions p53 overexpression correlated with breast cancer-specific death rates and adverse prognostic factors in patients treated with modified radical mastectomy. p53 overexpression might be a more reliable prognosticator in patients aged <50 years and with the triple-negative subtype. More effective systemic treatments might be warranted for these patients exhibiting p53 overexpression. Further validation is required to make more definite conclusions. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=4985409 Wed, 29 Jun 2011 23:00:00 +0100 4985409 http://www.medworm.com/index.php?rid=4985408&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F7%2F847%3Frss%3D1 Conclusions Through a combination of genome-wide expression and functional assays, we identified a set of genes with high potential as targets for drug development. This method is rapid and comprehensive and could be applied to the discovery of diagnostic biomarkers and therapeutic targets for cancers other than clear cell renal cell carcinoma. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=4985408 Wed, 29 Jun 2011 23:00:00 +0100 4985408 http://www.medworm.com/index.php?rid=4985407&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F7%2F841%3Frss%3D1 Conclusions The combined treatment with bone marrow stromal cell transplantation and vascular endothelial growth factor C administration is superior to bone marrow stromal cell transplantation alone in the treatment of limb lymphedema. Bone marrow stromal cell transplantation and vascular endothelial growth factor C administration could enhance the therapeutic effect of each other. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=4985407 Wed, 29 Jun 2011 23:00:00 +0100 4985407 http://www.medworm.com/index.php?rid=4985406&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F7%2F836%3Frss%3D1 (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=4985406 Wed, 29 Jun 2011 23:00:00 +0100 4985406 http://www.medworm.com/index.php?rid=4985405&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F7%2F835%3Frss%3D1 (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=4985405 Wed, 29 Jun 2011 23:00:00 +0100 4985405 http://www.medworm.com/index.php?rid=4985404&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F7%2FNP%3Frss%3D1 (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=4985404 Wed, 29 Jun 2011 23:00:00 +0100 4985404 http://www.medworm.com/index.php?rid=4872988&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F6%2F833%3Frss%3D1 (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=4872988 Thu, 26 May 2011 23:00:00 +0100 4872988 http://www.medworm.com/index.php?rid=4872987&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F6%2F832%3Frss%3D1 (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=4872987 Thu, 26 May 2011 23:00:00 +0100 4872987 http://www.medworm.com/index.php?rid=4872986&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F6%2F825%3Frss%3D1 Discussion focused on how to engage in measures to tackle cancer prevention and achieve early detection and effective treatment, using limited resources. It was recognized that with non-communicable diseases gaining increasing attention in international dialogue, it is now of the utmost importance to share an accurate recognition of cancer research and treatment throughout Asia and the wider world. Participants concurred that cancer issues are decoupled from the development aid agenda and that cooperation should be advanced on the basis of international cooperation without recourse to governmental development aid. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=4872986 Thu, 26 May 2011 23:00:00 +0100 4872986 http://www.medworm.com/index.php?rid=4872985&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F6%2F820%3Frss%3D1 We evaluated the efficacy of daunorubicin  (40 mg/m2/day for 5 days, 200 mg/m2/cycle) combined with standard dose of cytarabine (100 mg/m2/day for 7 days) for acute myelogenous leukemia patients aged 65–74 years as induction therapy. Complete remission (81.3%) was achieved in 13 of 16 patients following the therapeutic program. The median duration of recovering absolute neutolophilic counts over 1000/µl and platelet counts over 100 000/µl were 33 days and 27 days, respectively. None of the patients had any adverse cardiac complications or died during administration of the induction therapy. Patients achieving complete remission received post-remission therapy consisting of two regimens other than induction therapy. The 3-year disease-free and overall survival rates w... Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=4872985 Thu, 26 May 2011 23:00:00 +0100 4872985 http://www.medworm.com/index.php?rid=4872984&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F6%2F817%3Frss%3D1 A prospective multicenter trial has been commenced in Korea to investigate the treatment efficacy of the levonorgestrel-releasing intrauterine system in patients with endometrial hyperplasia. The levonorgestrel-releasing intrauterine system is an alternative to oral progesterone without the disadvantages of oral progestogens. Therefore, we hypothesize that if the therapeutic efficacy of the levonorgestrel-releasing intrauterine system is similar to or greater than that of oral progesterone, the levonorgestrel-releasing intrauterine system could become the standard treatment for endometrial hyperplasia patients who do not want a hysterectomy. The levonorgestrel-releasing intrauterine system is inserted into uteri of patients with histologically confirmed endometrial hyperplasia. An office e... Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=4872984 Thu, 26 May 2011 23:00:00 +0100 4872984 http://www.medworm.com/index.php?rid=4872983&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F6%2F814%3Frss%3D1 Malignant epithelioid variant of angiomyolipoma has aggressive characteristics, against which conventional cytotoxic agents have been reported to be disappointingly inactive, and the prognosis of unresectable or recurrent disease is dismal poor. A 52-year-old man with a history of left nephrectomy for epithelioid angiomyolipoma was referred to our institution. The computed tomographic scan showed a soft tissue dense mass around the Rex's recess and behind the spleen, and a large pelvic mass. Specimens obtained by percutaneous needle biopsy confirmed the recurrence of malignant epithelioid angiomyolipoma. Everolimus was initiated at 10 mg per day for recurrent disease. Computed tomographic scans 2 months later showed the tumors to be markedly decreased in size. The patient has continued wit... Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=4872983 Thu, 26 May 2011 23:00:00 +0100 4872983 http://www.medworm.com/index.php?rid=4872982&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F6%2F811%3Frss%3D1 We present a case, considered to be a form of the Koebner phenomenon, of bullous pemphigoid that was exacerbated mainly within the irradiated field after breast conservative radiotherapy. In May 2009, a 60-year-old woman was diagnosed with bullous pemphigoid, which was treated with steroid therapy. The following month, she was diagnosed with breast cancer (invasive ductal carcinoma, pT1cN0M0). After breast conservative surgery in December 2009, conservative radiotherapy to the right breast was performed (50 Gy in 25 fractions). Portal skin showed no serious change (up to grade 1 skin erythema) and no bullous neogenesis during conservative radiotherapy. However, 2 months after conservative radiotherapy, new blisters became exacerbated mainly within the irradiated field but also in the area ... Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=4872982 Thu, 26 May 2011 23:00:00 +0100 4872982 http://www.medworm.com/index.php?rid=4872981&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F6%2F807%3Frss%3D1 We present a case of ovarian squamous cell carcinoma that metastasized 8 years after cervical conization surgery for early microinvasive cervical carcinoma. She had no sign of recurrence in the uterine cervix. We detected human papillomavirus type 16 DNA in both cervical tissue and ovarian tissue, suggesting that ovarian squamous cell carcinoma is derived from microinvasive cervical cancer. Although there are very few cases of early microinvasive squamous cell carcinoma that metastasized to the ovary with delayed recurrence, we should pay attention strictly not only to the cervical condition but also to the ovarian condition on regular post-operative follow-up. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=4872981 Thu, 26 May 2011 23:00:00 +0100 4872981 http://www.medworm.com/index.php?rid=4872980&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F6%2F803%3Frss%3D1 The safety of chemotherapy for patients with systemic sclerosis is unclear, and there are few published reports documenting the side effects of chemotherapy in patients with this condition. Here, we report the case of a patient with systemic sclerosis who developed severe digital ischemia during combination gemcitabine/S-1 chemotherapy for pancreatic cancer. In spite of aggressive treatment, the digital ischemia progressively worsened and gangrenous changes developed in multiple fingers and toes. In this patient, the systemic sclerosis had been well controlled, with no digital ischemic symptoms for the previous 6 years, so this progressive clinical course in spite of aggressive treatment strongly suggests that the chemotherapy triggered or aggravated the digital necrosis. To the best of ou... Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=4872980 Thu, 26 May 2011 23:00:00 +0100 4872980 http://www.medworm.com/index.php?rid=4872979&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F6%2F797%3Frss%3D1 Pleomorphic carcinomas of the lung are rare malignant biphasic tumors composed of carcinomatous and sarcomatous components. The carcinomatous component is usually an adenocarcinoma or a squamous cell carcinoma, and the sarcomatous component is usually a spindle cell carcinoma. Recently, we encountered two patients who underwent surgery for pleomorphic carcinoma whose carcinomatous component was large cell neuroendocrine carcinoma. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=4872979 Thu, 26 May 2011 23:00:00 +0100 4872979 http://www.medworm.com/index.php?rid=4872978&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F6%2F792%3Frss%3D1 Conclusions Adrenal involvement in primary renal cell carcinoma was observed more frequently in patients with advanced tumor stages. In the TNM classification system, we propose that ipsilateral solitary adrenal involvement in renal cell carcinoma should be staged as M1. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=4872978 Thu, 26 May 2011 23:00:00 +0100 4872978 http://www.medworm.com/index.php?rid=4872977&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F6%2F783%3Frss%3D1 Conclusions From this study, we found that further education and practical training will be needed for adequate cancer pain management for young physicians in their early career. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=4872977 Thu, 26 May 2011 23:00:00 +0100 4872977 http://www.medworm.com/index.php?rid=4872976&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F6%2F776%3Frss%3D1 Conclusions Survival of our Ewing sarcoma family of tumors patients was not inferior to those reported for Euro-American cases. Collaborative studies are necessary for further improvements of outcome and we believe that our data provide a basis for future studies targeting Ewing sarcoma family of tumors. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=4872976 Thu, 26 May 2011 23:00:00 +0100 4872976 http://www.medworm.com/index.php?rid=4872975&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F6%2F770%3Frss%3D1 Conclusions Transcatheter arterial infusion chemotherapy using a fine-powder formulation of cisplatin appears to have only modest activity, although the toxicity was also only mild, in patients with transcatheter arterial chemoembolization-refractory hepatocellular carcinoma. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=4872975 Thu, 26 May 2011 23:00:00 +0100 4872975 http://www.medworm.com/index.php?rid=4872974&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F6%2F764%3Frss%3D1 Conclusions Although systemic relapses, short survival time after relapse and death from other causes occurred, no loco-regional relapses were observed. Less intensive radiotherapy such as low-dose and small field might not compromise the treatment outcome for this population. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=4872974 Thu, 26 May 2011 23:00:00 +0100 4872974 http://www.medworm.com/index.php?rid=4872973&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F6%2F758%3Frss%3D1 Conclusions These results indicate that head and neck reconstruction with free flaps is reliable. However, the high 30-day post-operative mortality rate among patients 80 years or older should be considered when deciding whether to operate. To decrease the operative mortality rate, careful perioperative management is needed to prevent complications and shorten the hospital stay. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=4872973 Thu, 26 May 2011 23:00:00 +0100 4872973 http://www.medworm.com/index.php?rid=4872972&cid=s_31098_6_f&fid=31098&url=http%3A%2F%2Fjjco.oxfordjournals.org%2Fcgi%2Fcontent%2Fshort%2F41%2F6%2F752%3Frss%3D1 Conclusions Our study found Taiwanese patients with end-stage renal disease to have a higher risk to develop urinary tract, liver and breast cancer. We unexpectedly discovered these patients to have a lower risk to get lung, prostate and esophageal cancer. (Source: Japanese Journal of Clinical Oncology) Japanese Journal of Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=4872972 Thu, 26 May 2011 23:00:00 +0100 4872972