MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Journal of Affective Disorders' source. Wed, 08 Feb 2012 20:43:10 +0100 http://www.medworm.com/index.php?rid=5459651&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711005702%2Fabstract%3Frss%3Dyes Abstract: Background: The railway suicide of Robert Enke, an internationally respected German football goal keeper, sent shockwaves throughout the world of football. We analyzed its impact on the frequency of subsequent railway suicide acts (RS).Methods: Two analytic approaches were performed applying German Railway Event database Safety (EDS) data: first, an inter-year approach comparing the incidence of RS during a predefined “index period” with identical time windows in 2006 to 2008; second, an intra-year approach comparing the number of RS 28days before and after the incidence. To analyze a possible “compensatory deficit”, the number of RS in the subsequent first quarter of 2010 was compared with the identical time windows in the preceding three years. Incidence ratios with 95%... Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459651 Thu, 01 Dec 2011 14:23:58 +0100 5459651 http://www.medworm.com/index.php?rid=5459650&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711005428%2Fabstract%3Frss%3Dyes Conclusions: This study failed to find evidence of gene–environment interplay in recurrent clinical depression. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459650 Thu, 01 Dec 2011 14:23:58 +0100 5459650 http://www.medworm.com/index.php?rid=5459649&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711005507%2Fabstract%3Frss%3Dyes Abstract: Background: The Wnt/GSK3β signaling pathway was implicated in mood disorders. Beta-catenin is a protein targeted by this signaling axis. We aimed to examine whether there is an abnormality in this signaling axis in major depression.Methods: Postmortem brains from 20 depressed and 20 non-depressed subjects were used. In both groups, suicide and non-suicide were included in equal number. Protein levels of β-catenin, tGSK3β and ser9-pGSK3β were determined in prefrontal cortex.Results: ANOVA yielded significant variations between groups in β-catenin (F3,36=19.5; p (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459649 Thu, 01 Dec 2011 14:23:58 +0100 5459649 http://www.medworm.com/index.php?rid=5459648&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004344%2Fabstract%3Frss%3Dyes Conclusions: Plasma VEGF levels were elevated in patients with acute episodes of major depressive disorder and bipolar disorder. Such an alteration of VEGF in acute episode, mood disorders may be associated with a neuroprotective role for VEGF. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459648 Thu, 01 Dec 2011 14:23:58 +0100 5459648 http://www.medworm.com/index.php?rid=5459647&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004368%2Fabstract%3Frss%3Dyes Abstract: Mood disorders represent a major medical need, as their chronic treatments are not effective in all patients. Literature data suggested that phosphoinositides (PI) signal transduction pathway and related molecules such as the Phosphoinositide-specific Phospholipase C (PI-PLC) enzymes, might be involved in the pathophysiology of mood disorders, including major depression. By using interphase fluorescent in situ hybridization methodology, we analyzed PLCB1 gene, which codifies for the PI-PLC β1 enzyme, in paraffin embedded samples of orbito-frontal cortex of 15 patients affected with major depression and in 15 normal controls. No deletions of PLCB1 were identified with the methodology used, which allows to exclude wide gene deletions. The results, the technical aspects of the FISH... Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459647 Thu, 01 Dec 2011 14:23:58 +0100 5459647 http://www.medworm.com/index.php?rid=5459646&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004538%2Fabstract%3Frss%3Dyes Conclusions: These preliminary results seem to support the hypothesis that in patients unresponsive to SSRIs the administration of antidepressants with different mechanisms of action is an effective switching strategy. Further studies are needed in light of the challenge posed by resistant depression. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459646 Thu, 01 Dec 2011 14:23:58 +0100 5459646 http://www.medworm.com/index.php?rid=5459645&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003302%2Fabstract%3Frss%3Dyes Conclusion: This study did not demonstrate evidence that long-term treatment of affectively ill patients with TSDL accelerates loss of BMD compared to an age- and gender-matched reference population. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459645 Thu, 01 Dec 2011 14:23:58 +0100 5459645 http://www.medworm.com/index.php?rid=5459644&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003338%2Fabstract%3Frss%3Dyes Conclusion: Our study on ischemic stroke patients suggested that certain neuroanatomical factors (i.e., lesions at posterior limb and genu of internal capsule and cortical–subcortical area of the temporal lobe, as well as the presence of multiple acute infarcts) may correlate with the PSD development. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459644 Thu, 01 Dec 2011 14:23:58 +0100 5459644 http://www.medworm.com/index.php?rid=5459643&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032710007111%2Fabstract%3Frss%3Dyes Conclusions: The Suicide Intent Scale is a valuable tool in clinical suicide risk assessment, a shorter version of the scale may offer a better predictive value. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459643 Thu, 01 Dec 2011 14:23:58 +0100 5459643 http://www.medworm.com/index.php?rid=5459642&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711005660%2Fabstract%3Frss%3Dyes Conclusions: The results confirm our previous observations and strongly suggest that memantine, as augmenting agent, was associated with a clinically substantial antimanic and sustained mood-stabilizing effect, with excellent safety and tolerability profile. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459642 Thu, 01 Dec 2011 14:23:58 +0100 5459642 http://www.medworm.com/index.php?rid=5459641&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004277%2Fabstract%3Frss%3Dyes Conclusions: Three depression screening tools—the EPDS, CES-D, and BDI-II—appear to be reliable and brief assessments of major and minor depression among low-income African American perinatal women. Providers using these tools should consider using lower cutoff scores to most effectively identify women in need of depression treatment. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459641 Thu, 01 Dec 2011 14:23:58 +0100 5459641 http://www.medworm.com/index.php?rid=5459640&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711005234%2Fabstract%3Frss%3Dyes Conclusions: The course of bipolar-I disorder from onset was largely random or chaotic over nearly 6years from onset. Only a minority of patients showed either cycle-acceleration or slowing, without changes in wellness intervals. The findings may be influenced by treatment-effects, but seem to indicate that most current bipolar-I disorder patients are unlikely to show progressive shortening of recurrence-cycles. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459640 Thu, 01 Dec 2011 14:23:58 +0100 5459640 http://www.medworm.com/index.php?rid=5459639&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711005349%2Fabstract%3Frss%3Dyes Conclusions: Anger is a common symptom in outpatient psychiatry clinics. It is associated with both mood and anxiety disorder diagnoses, and often co-occurs with substance use problems. Different types of angry patients will likely require different assessment and treatment approaches. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459639 Thu, 01 Dec 2011 14:23:58 +0100 5459639 http://www.medworm.com/index.php?rid=5459638&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004976%2Fabstract%3Frss%3Dyes Conclusion: The major C allele of the IL18 rs187238 and the major G allele rs1946518 have previously been associated with higher expression of IL-18 mRNA. Our data suggest that this genetic trend towards higher IL-18 production may increase the susceptibility to depression in response to stressful life events. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459638 Thu, 01 Dec 2011 14:23:58 +0100 5459638 http://www.medworm.com/index.php?rid=5459637&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004927%2Fabstract%3Frss%3Dyes Conclusions: The pattern of associations between CBF and AL suggest disbalanced motor control in MDD. Findings are in line with the hypothesis of dopamine deficits contributing to motor retardation in MDD. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459637 Thu, 01 Dec 2011 14:23:58 +0100 5459637 http://www.medworm.com/index.php?rid=5459636&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004939%2Fabstract%3Frss%3Dyes Conclusions: 18months after the Sichuan earthquake, the incidence of depression and PTSD were still quite high among pregnant women in the earthquake stricken areas. Depression was more common than PTSD. Living through an earthquake has been significantly correlated with PTSD but not with depression. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459636 Thu, 01 Dec 2011 14:23:58 +0100 5459636 http://www.medworm.com/index.php?rid=5459635&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004940%2Fabstract%3Frss%3Dyes Abstract: Background: Weight gain and increased production of leptin may be associated with immuno-modulation and insulin resistance in bipolar disorder. The links among inflammatory markers, leptin, and insulin of bipolar patients from acute mania to full remission remain unclear.Methods: Thirty-three healthy, bipolar I patients under 45years of age were enrolled. We measured the circulating levels of high-sensitivity C-reactive protein (hs-CRP), anti-inflammatory mediators (interleukin-1 receptor antagonist [IL-1Ra] and soluble tumor necrosis factor receptor 1 [sTNF-R1]), leptin, and insulin during acute mania and subsequent partial and full remission. The results were compared with 33 age- and gender-matched healthy subjects.Results: The levels of IL-1Ra and hs-CRP of bipolar patients i... Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459635 Thu, 01 Dec 2011 14:23:58 +0100 5459635 http://www.medworm.com/index.php?rid=5459634&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004848%2Fabstract%3Frss%3Dyes Conclusions: PCMDs in men are an unrecognised public health problem in northern Vietnam. Overall the cut off scores to detect clinically significant symptoms are lower than those reported in high income settings. Cut off scores on the EPDS and Zung SAS are slightly higher in men than in women in northern Vietnam, but these scales are suitable for use with men in this setting. Although not suitable to detect PCMD in women, the GHQ-12 is suitable to detect PCMD in men. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459634 Thu, 01 Dec 2011 14:23:58 +0100 5459634 http://www.medworm.com/index.php?rid=5459633&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS016503271100485X%2Fabstract%3Frss%3Dyes Abstract: Background: Chronic treatment with selective serotonin reuptake inhibitors (SSRIs) reduces the risk and severity of cardiovascular diseases. SSRIs block the serotonin transporter, thereby inhibiting serotonin (5-HT) uptake into presynaptic neurons as well as into platelets where 5-HT is stored in dense granules. When 5-HT is released in response to agonists it enhances platelet aggregation induced by injury-related signals. Chronic administration of SSRIs may thus reduce platelet aggregability secondary to depletion of platelets' serotonin stores.Methods: The study included ten DSM-IV-TR major depression (MDD) and four obsessive compulsive disorder (OCD) patients and fourteen healthy untreated age- and sex-matched controls. The patients were chronically medicated (6–108months) ... Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459633 Thu, 01 Dec 2011 14:23:58 +0100 5459633 http://www.medworm.com/index.php?rid=5459632&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004861%2Fabstract%3Frss%3Dyes Abstract: Background: Social anxiety is characterized by the experience of stress, discomfort and fear in social situations, and is associated with substantial personal and societal burden. Two questionnaires exist that assess the aspects of social anxiety, i.e. social interaction anxiety (SIAS) and social phobia (SPS). There is no agreement in literature on the dimensionality of social anxiety. Further, the length of a questionnaire may negatively affect response rates and participation at follow-up occasions.Aim: To explore the structure of social anxiety in the general population, and to examine psychosocial and sociodemographic correlates. Our second aim was to construct abbreviated versions of SIAS and SPS that can be easily used and with minimal burden.Method: A total of 1598 adults ... Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459632 Thu, 01 Dec 2011 14:23:58 +0100 5459632 http://www.medworm.com/index.php?rid=5459631&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004873%2Fabstract%3Frss%3Dyes Conclusion: The three empirically identified subgroups of BPI patients exhibited distinguished comorbidity patterns and clinical features, including suicidal behaviors, frequent mood episodes and functional impairments. Our findings have clinical implication in intervention and treatment as well as to explore their different underlying mechanisms. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459631 Thu, 01 Dec 2011 14:23:58 +0100 5459631 http://www.medworm.com/index.php?rid=5459630&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004885%2Fabstract%3Frss%3Dyes Conclusion: The lack of superiority of high intensity blue-enriched light over standard bright light treatment does not clearly support nor rule out the possibility of an important role for the circadian system or the blue sensitive non-visual image forming system in general, in the pathophysiology of SAD. The lack of a difference between conditions may also be the result of a saturated response to the high light intensities used. Recent data indeed suggest that low intensity blue-enriched light may be as effective as standard bright light treatment. The possibility of improving light therapy for SAD patients by applying light of shorter duration or at lower light intensities is highly relevant for optimizing treatment and will help to clarify the role of the circadian system and/or the no... Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459630 Thu, 01 Dec 2011 14:23:58 +0100 5459630 http://www.medworm.com/index.php?rid=5459629&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004897%2Fabstract%3Frss%3Dyes Conclusions: The altered EAATs and DAT expression could result in altered glutamatergic and hyperdopaminergic function in BD and SZ. Differently altered EAATs involved in glutamatergic transmission could be therapeutic targets for treating BD and SZ. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459629 Thu, 01 Dec 2011 14:23:58 +0100 5459629 http://www.medworm.com/index.php?rid=5459628&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003661%2Fabstract%3Frss%3Dyes Conclusions: A heightened ruminative response was not only found among individuals with MDD, but also among those with BPD and GAD/OCD; this might indicate ineffective thought control. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459628 Thu, 01 Dec 2011 14:23:58 +0100 5459628 http://www.medworm.com/index.php?rid=5459627&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003685%2Fabstract%3Frss%3Dyes Abstract: Background: High comorbidity rates for anxiety have been documented in subjects with history of mania or hypomania. We explored the presence of latent constructs of quantitative anxiety in subjects who have a history of mania or hypomania.Methods: We conducted an exploratory factor analysis of anxiety trait in 212 subjects who have a lifetime history of at least one manic/hypomanic syndrome. Participants were originally recruited for a Costa Rican sibling pair genetic study of Bipolar Disorder. We used principal factors extraction method with squared multiple correlations (SAS/SAT Professional software) of the STAI (trait subscale).Results: A three-factor solution with a good simple structure and statistical adequacy was obtained with a KMO of 0.84 (>0.6) and Bartlett's Test of S... Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459627 Thu, 01 Dec 2011 14:23:58 +0100 5459627 http://www.medworm.com/index.php?rid=5459626&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003636%2Fabstract%3Frss%3Dyes Conclusion: Depression was prevalent in a sample of Egyptian female secondary school students. It correlated with some psychosocial factors and can be effectively screened using CDI. Hence, there is a need for better screening, Psychoeducational programmes, and services for better identification, early intervention and targeting for those at risk. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459626 Thu, 01 Dec 2011 14:23:58 +0100 5459626 http://www.medworm.com/index.php?rid=5459625&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711005350%2Fabstract%3Frss%3Dyes Conclusions: We found little evidence that participation of prisoners in interview-based research on suicidal behaviour has negative effects on them; indeed, it can be beneficial. Inclusion of similar instruments to measure the effects of research participation in future investigations could provide valuable feedback to researchers and ethics committees. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459625 Thu, 01 Dec 2011 14:23:58 +0100 5459625 http://www.medworm.com/index.php?rid=5459624&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711005283%2Fabstract%3Frss%3Dyes Conclusions: This study suggests that particular features of parental depression, specifically past depression severity and presence of a recent episode, may be important indicators of risk for child psychiatric disorder and depressive symptoms. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459624 Thu, 01 Dec 2011 14:23:58 +0100 5459624 http://www.medworm.com/index.php?rid=5459623&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711005271%2Fabstract%3Frss%3Dyes Conclusions: Repeaters must be considered as a specific population among suicide attempters and gender differences must be taken into account in this particular population in order to promote more personalized prevention programs for suicidal recurrence and completed suicide. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459623 Thu, 01 Dec 2011 14:23:58 +0100 5459623 http://www.medworm.com/index.php?rid=5459622&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711005209%2Fabstract%3Frss%3Dyes This study assessed the association between Type D personality (the conjoint effect of negative affectivity and social inhibition) and quality of life (QoL) and mental health of cancer survivors up to 10years post-diagnosis.Methods: All currently alive individuals diagnosed with endometrial or colorectal cancer between 1998 and 2007, or with lymphoma or multiple myeloma between 1999 and 2008 as registered in the Eindhoven Cancer Registry received a questionnaire on Type D personality (DS14), QoL (SF-36 or EORTC-QLQ-C30) and mental health (HADS).Results: Of the 3080 survivors who responded (69%), 572 (19%) had a Type D personality. Type D survivors had clinically meaningful lower levels of general health, social functioning, role-function emotional, mental health and vitality compared to no... Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459622 Thu, 01 Dec 2011 14:23:58 +0100 5459622 http://www.medworm.com/index.php?rid=5459621&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711005155%2Fabstract%3Frss%3Dyes Abstract: Background: Although perfectionism from a multidimensional perspective has generally been associated with depressive illness, there are not many studies on its role in major depression in the postnatal period. The aim of the present study was to explore the relationship between perfectionism dimensions using the Frost Multidimensional Perfectionism Scale (FMPS) and major postpartum depression.Methods: One-hundred-twenty-two women with major postpartum depression (SCID-I; DSM-IV) and 115 healthy postpartum women were evaluated using the FMPS, an instrument for the assessment of six perfectionism dimensions: concern over mistakes, personal standards, parental expectations, parental criticism, doubt about actions and organisation. Other variables were also considered: neuroticism, p... Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459621 Thu, 01 Dec 2011 14:23:58 +0100 5459621 http://www.medworm.com/index.php?rid=5459620&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711005179%2Fabstract%3Frss%3Dyes Abstract: Background: In most countries worldwide suicide rates are higher for males whereas attempted suicide rates are higher for females. The aim is to investigate if the choice of more lethal methods by males explains gender differences in suicide rates.Methods: Data on completed and attempted suicides were collected (n=3235, Nuremberg and Wuerzburg, years 2000–2004). The research question was analyzed by comparing the method-specific case fatality (= completed suicides/completed+attempted suicides) for males and females.Results: Among the events captured, men chose high-risk methods like hanging significantly more often than women (φ=−0.27; p (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459620 Thu, 01 Dec 2011 14:23:58 +0100 5459620 http://www.medworm.com/index.php?rid=5459619&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711005131%2Fabstract%3Frss%3Dyes Conclusions: Within 2years of first-hospitalizations, 41% of patients initially diagnosed with psychotic-depression met criteria for DSM-IV bipolar or schizoaffective disorders. Of the 59% retaining the initial diagnosis for 2years, nearly half experienced new episodes, 42% remained symptomatic, and two-thirds failed to regain their own prior functional status. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459619 Thu, 01 Dec 2011 14:23:58 +0100 5459619 http://www.medworm.com/index.php?rid=5459618&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032710004581%2Fabstract%3Frss%3Dyes Conclusions: Paliperidone ER 12mg/day was superior to placebo in the treatment of acute mania. Change from baseline in YMRS total score increased with the dose of paliperidone ER. Paliperidone ER was generally tolerated by patients with bipolar I disorder and no new safety signal was detected. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459618 Thu, 01 Dec 2011 14:23:58 +0100 5459618 http://www.medworm.com/index.php?rid=5459617&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032710000066%2Fabstract%3Frss%3Dyes Abstract: Affective temperament and psychopathological traits such as separation anxiety (SA) and interpersonal sensitivity (IPS) are supposed to impact on the clinical manifestation and on the course of Bipolar Disorder (BD); in the present study we investigated their influence on the definition of BD subtypes.Method:: Among 106 BD-I patients with DSM-IV depressive, manic or mixed episode included in a multi-centric Italian study and treated according to the routine clinical practice, 89 (84.0%) were in remission after a follow-up period ranging from 3 to 6months (Clinical Global Impression-BP [CGI-BP] (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459617 Thu, 01 Dec 2011 14:23:58 +0100 5459617 http://www.medworm.com/index.php?rid=5459616&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003533%2Fabstract%3Frss%3Dyes Conclusion: Evidence suggests potential benefits of zinc supplementation as a stand-alone intervention or as an adjunct to conventional antidepressant drug therapy for depression. However, there are methodological limitations in existing studies and so further well-designed, adequately powered research is required. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459616 Thu, 01 Dec 2011 14:23:58 +0100 5459616 http://www.medworm.com/index.php?rid=5459615&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711002849%2Fabstract%3Frss%3Dyes Conclusions: There is insufficient published data to confirm an association between 5HTTLPR and antidepressant induced mania. Pharmacogenomic studies of antidepressant induced mania have high potential clinical impact provided future studies are of adequate sample size and include rigorously assessed patient characteristics (e.g. ancestry, rapid cycling, concurrent mood stabilization, and length of antidepressant exposure). (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459615 Thu, 01 Dec 2011 14:23:58 +0100 5459615 http://www.medworm.com/index.php?rid=5459614&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711002515%2Fabstract%3Frss%3Dyes Conclusions: The results of these clinical and psychopharmacological studies appear to confirm an association between bipolarity and a poor response of depression to treatment with antidepressant drugs. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459614 Thu, 01 Dec 2011 14:23:58 +0100 5459614 http://www.medworm.com/index.php?rid=5459613&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032710007317%2Fabstract%3Frss%3Dyes Abstract: Self-focus (i.e. the process by which one engages oneself in self-referential processing) is a core issue in the psychopathology of major depression. The cortical midline structures, including the medial prefrontal cortex (MPFC), play a key role in self-referential processing in healthy subjects. Four functional magnetic resonance imaging studies recently found either an increased or a decreased MPFC activation during self-referential processing in depressed patients compared to healthy controls. Building on critical differences in experimental settings, we argue that these conflicting results are indeed consistent with two modes of elevated MPFC activation in major depression. An elevated tonic ventral MPFC activation, as uncovered by an event-related design, may embody automati... Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5459613 Thu, 01 Dec 2011 14:23:58 +0100 5459613 http://www.medworm.com/index.php?rid=5365576&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711005143%2Fabstract%3Frss%3Dyes Conclusions: Recurrent mood swings and irritability/aggressiveness are characterized as inexplicable and exaggerated responses, respectively, and may be the most prominent genuine clinical predictors of the FMAE of BD-II. Future studies need to investigate the extent to which the presence of different characteristics of the same symptoms discriminate between individuals who later develop BD and those who do not. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365576 Thu, 03 Nov 2011 23:29:33 +0100 5365576 http://www.medworm.com/index.php?rid=5365575&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004952%2Fabstract%3Frss%3Dyes We examined serum IgM antibodies to the conjugated fatty acids, palmitic and myristic acids; acetylcholine; S-farnesyl-l-cysteine; and NO-modified adducts in 26 depressed patients and 17 normal controls. Severity of depression was measured with the Hamilton Depression Rating Scale and severity of fatigue and somatic (F&S) symptoms with the Fibromyalgia and Chronic Fatigue Syndrome (FF) Rating Scale.Results: The prevalences and mean values for the serum IgM levels directed against conjugated palmitic and myristic acids, acetylcholine, S-farnesyl-l-cysteine; and the conjugated NO adducts, NO-tyrosine, NO-phenylalanine, NO-aspartate, NO-histidine, and NO-creatine were significantly higher in depressed patients than in normal controls. The autoimmune responses were significantly related to FF ... Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365575 Thu, 03 Nov 2011 23:29:33 +0100 5365575 http://www.medworm.com/index.php?rid=5365574&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004678%2Fabstract%3Frss%3Dyes Discussion: The results are consistent with the results of studies in healthy adults and MD patients. The present study suggests that an altered pattern of regional brain responses to sad stimuli, is already present in childhood and might represent vulnerability for MD later in life. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365574 Thu, 03 Nov 2011 23:29:33 +0100 5365574 http://www.medworm.com/index.php?rid=5365573&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004307%2Fabstract%3Frss%3Dyes Conclusion: Patients with MDD showed selective increases in posterior hippocampal volumes which were not correlated to the degree of functional restitution. However, posterior hippocampal volume increases might constitute a surrogate parameter of neuroplasticity taking place during antidepressant therapy which might be predicted by executive functioning at baseline. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365573 Thu, 03 Nov 2011 23:29:33 +0100 5365573 http://www.medworm.com/index.php?rid=5365572&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004162%2Fabstract%3Frss%3Dyes Conclusions: Our data show that no correlation exists between TrkB gene methylation and suicide in Wernicke area, confirming that expression and methylation state of suicide-related genes, even belonging to the same pathway, may be specific for brain area. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365572 Thu, 03 Nov 2011 23:29:33 +0100 5365572 http://www.medworm.com/index.php?rid=5365571&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004149%2Fabstract%3Frss%3Dyes Abstract: Purpose: In previous studies, benign prostatic enlargement (BPE) and urinary tract symptoms were demonstrated to be associated with depressive symptoms. However, no longitudinal follow-up study to date has evaluated the relationship between BPE and the subsequent risk of developing depressive disorder. This nationwide, population-based study aimed to prospectively examine the relationship between a history of BPE and the risk of developing depressive disorder.Materials and methods: A total of 16,130 adult patients diagnosed with BPE for the first time between 2005 and 2007 were recruited along with a comparison cohort of 48,390 matched enrollees without a history of BPE. All the subjects were tracked for a one-year period following their index date to identify those who subsequen... Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365571 Thu, 03 Nov 2011 23:29:33 +0100 5365571 http://www.medworm.com/index.php?rid=5365570&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003247%2Fabstract%3Frss%3Dyes This study reports data on the treatment of 149 individuals with moderate depression during the 2month open label phase of a randomised placebo controlled clinical trial of the efficacy of 1g BID of NAC that examined the use of NAC as a maintenance treatment for bipolar disorder.Results: In this trial, the estimated mean baseline Bipolar Depression Rating Scale (BDRS) score was 19.7 (SE=0.8), and the mean BDRS score at the end of the 8week open label treatment phase was 11.1 (SE=0.8). This reduction was statistically significant (p (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365570 Thu, 03 Nov 2011 23:29:33 +0100 5365570 http://www.medworm.com/index.php?rid=5365569&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003259%2Fabstract%3Frss%3Dyes Abstract: Background: Reduced social rhythmicity is a commonly reported feature of bipolar disorder which may extend to non-clinical populations at risk of bipolar disorder. The aim of the current study was to investigate social rhythms across three groups of participants; a clinical group of bipolar disorder outpatients, and two non-clinical groups with high- and low-vulnerability to bipolar disorder, respectively. It was expected that reduced social rhythmicity would differentiate the clinical group from the low-vulnerability group, but not the high vulnerability group.Methods: Non-clinical participants were selected on the basis of scores derived from the General Behaviour Inventory and allocated to groups of high (n=36) and low (n=36) trait vulnerability to bipolar disorder. The clinic... Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365569 Thu, 03 Nov 2011 23:29:33 +0100 5365569 http://www.medworm.com/index.php?rid=5365568&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003211%2Fabstract%3Frss%3Dyes Conclusions: Despite limitations our results support the hypothesis that vulnerability for mania is associated with daydreaming. Daydreaming was related to mania and depression which highlights that it might be relevant for the etiology or maintenance of mood disorders. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365568 Thu, 03 Nov 2011 23:29:33 +0100 5365568 http://www.medworm.com/index.php?rid=5365567&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS016503271100320X%2Fabstract%3Frss%3Dyes Conclusions: Contrary to our hypothesis, no difference in total pineal volume between patients with bipolar disorder and healthy subjects was observed. These results indicate that the putative dysfunction of the pineal gland in bipolar disorder could be not directly related to an abnormal volume of the pineal gland. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365567 Thu, 03 Nov 2011 23:29:32 +0100 5365567 http://www.medworm.com/index.php?rid=5365566&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS016503271100512X%2Fabstract%3Frss%3Dyes Conclusion: This study suggests that the genetic polymorphisms in 5HT2A receptor and serotonin transporter are linked to discrete symptom clusters of MDD. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365566 Thu, 03 Nov 2011 23:29:32 +0100 5365566 http://www.medworm.com/index.php?rid=5365565&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS016503271100468X%2Fabstract%3Frss%3Dyes Conclusion: Antenatal depression is high and clinical presentation is similar to high income countries. Standardised diagnostic tools are culturally sensitive and adequate for early detection. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365565 Thu, 03 Nov 2011 23:29:32 +0100 5365565 http://www.medworm.com/index.php?rid=5365564&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS016503271100423X%2Fabstract%3Frss%3Dyes Conclusions: Further study of creatine as an adjunctive treatment for adolescents with SSRI-resistant MDD is warranted. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365564 Thu, 03 Nov 2011 23:29:32 +0100 5365564 http://www.medworm.com/index.php?rid=5365563&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004241%2Fabstract%3Frss%3Dyes Abstract: Background: While it has been reported that physicians may under-recognize adverse effects of antidepressants thoroughly in clinical settings, subjective bias in recognition of adverse effects (AEs) with antidepressants has not been specifically investigated.Methods: Four-hundred ninety-three participants with depressive disorders (ICD-10) were assessed for the severity of 20 common AEs and their inferred causal relationship with antidepressants, together with the Quick Inventory for Depressive Symptoms (QIDS). These assessments occurred twice at the 1st visit (when they were antidepressant free) and 2nd visit (10days after the initiation of antidepressants). ‘Possible AEs’ and ‘under-recognized AEs’ were defined as ‘events with exacerbation in the severity’ and ‘ev... Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365563 Thu, 03 Nov 2011 23:29:32 +0100 5365563 http://www.medworm.com/index.php?rid=5365562&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004253%2Fabstract%3Frss%3Dyes Abstract: Background: The time frame for postpartum depression (PPD) defined in the literature differs among studies — either 4weeks or 3months after childbirth. To address potential difference in PPD in relation to onset of the illness, we investigated risk factors for early- and late-onset PPD using a representative birth cohort in Japan.Methods: We evaluated 675 women who completed the Edinburgh Postnatal Depression Scale (EPDS) for two to three times within 3months after childbirth. Mothers with an onset of PPD (≥9 points on EPDS) within 4weeks after childbirth were classified as having early-onset PPD, and those with PPD that occurred during the period of the 5th to 12th week after childbirth were classified as having late-onset PPD. We adopted multinomial logistic regression to i... Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365562 Thu, 03 Nov 2011 23:29:32 +0100 5365562 http://www.medworm.com/index.php?rid=5365561&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003909%2Fabstract%3Frss%3Dyes Conclusions: The different pattern of regional brain activation found here during transient sadness – in children carrying the T allele, compared to those carrying the C allele – might increase later in life susceptibility to emotional dysregulation and depressive symptoms. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365561 Thu, 03 Nov 2011 23:29:32 +0100 5365561 http://www.medworm.com/index.php?rid=5365560&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003922%2Fabstract%3Frss%3Dyes Abstract: Background: Brain-derived neurotrophic factor (BDNF) is a member of the nerve growth factor family and plays a critical role in growth, differentiation, maintenance and synaptic plasticity of neuronal systems. Previous studies have demonstrated lower serum BDNF concentrations in major depressive disorder (MDD), with concentrations negatively correlating with the severity of the disease. However, few investigations have examined the relationship between serum BDNF and detailed clinical symptoms. The aim of present study was to clarify the magnitudes of the relationships between various depressive symptom and serum BDNF.Methods: Serum BDNF concentrations were evaluated from 109 inpatients with MDD and 163 healthy controls. Depressive symptoms were assessed using the Hamilton rating... Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365560 Thu, 03 Nov 2011 23:29:32 +0100 5365560 http://www.medworm.com/index.php?rid=5365559&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003995%2Fabstract%3Frss%3Dyes Conclusions: Our findings suggested the abnormality of limbic–cortical networks in first-episode, treatment-naïve, short-illness-duration, and treatment-response MDD patients, and added an expanding literature to the abnormality hypothesis of limbic-cortical networks in MDD. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365559 Thu, 03 Nov 2011 23:29:32 +0100 5365559 http://www.medworm.com/index.php?rid=5365558&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004010%2Fabstract%3Frss%3Dyes Conclusions: These results suggest that ERs’ personality characteristics are different from those of other patients with MDD and that evaluating patients’ personality using the TCI at baseline may predict their antidepressant response.Limitations: Our sample of patients with MDD was small. Some of the patients with severe MDD had difficulty completing the TCI. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365558 Thu, 03 Nov 2011 23:29:32 +0100 5365558 http://www.medworm.com/index.php?rid=5365557&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004034%2Fabstract%3Frss%3Dyes Conclusions: This is the first study to test whether remission from geriatric depression depends on lesion volume by ROI in an outpatient sample. The pattern of remission rates and odds ratios was similar when patients were classified as having high DWMH, PVH or total volume suggesting that lesion location may not be critical. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365557 Thu, 03 Nov 2011 23:29:32 +0100 5365557 http://www.medworm.com/index.php?rid=5365556&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004083%2Fabstract%3Frss%3Dyes Conclusions: Combat-related posttraumatic stress disorder and depressive symptoms in treatment-seeking OEF/OIF/OND veterans may be better conceptualized by four dimensions of reexperiencing/avoidance, detachment/numbing, hopelessness/depression, and bodily disturbance symptoms. This symptom structure may provide greater utility when examining other outcomes of interest in this population. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365556 Thu, 03 Nov 2011 23:29:32 +0100 5365556 http://www.medworm.com/index.php?rid=5365555&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004101%2Fabstract%3Frss%3Dyes Abstract: Background: Recent data suggest that cerebellum influences emotion modulation in humans. The findings of cerebellar abnormalities in bipolar disorder (BD) are especially intriguing given the link between the cerebellum emotional and behavioral regulation. The purpose of this study was to evaluate cerebellar volume in patients with euthymic BD type I compared to controls. Moreover, we investigated the possible relationship between cerebellar volume and suicidal behavior.Methods: Forty-patients with euthymic BD type I, 20 with and 20 without history of suicide attempt, and 22 healthy controls underwent an MRI scan. The participants were interviewed using the Structured Clinical Interview with the DSM-IV axis I (SCID-I), the Hamilton Depression Rating Scale (HDRS), the Young Mania R... Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365555 Thu, 03 Nov 2011 23:29:32 +0100 5365555 http://www.medworm.com/index.php?rid=5365554&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004113%2Fabstract%3Frss%3Dyes Abstract: Background:: Bipolar disorder (BD) is associated with alterations in mood, personality, cognition and event-related potential (ERP) measures. The relationship between these multidimensional measures of state and subsequent course of the illness is not well understood. Therefore, this study aimed to prospectively identify factors that predicted the course of mood episodes.Methods:: Sixty-five participants with BD were administered the auditory P300 oddball task, clinical assessment instruments and cognitive tests at baseline, and were subsequently administered the SCID interview once a month by telephone for 12months.Results:: Hierarchical regression analyses indicated that the Montgomery–Asberg Depression Rating Scale (MADRS) predicted the number of months spent in a depressed ... Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365554 Thu, 03 Nov 2011 23:29:32 +0100 5365554 http://www.medworm.com/index.php?rid=5365553&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003569%2Fabstract%3Frss%3Dyes Conclusion: We propose that creativity in BD might be linked to the putative hyperdopaminergic state of mania and be dependent on intact executive function. Future studies should further explore the role of dopaminergic mechanisms in creativity in BD. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365553 Thu, 03 Nov 2011 23:29:32 +0100 5365553 http://www.medworm.com/index.php?rid=5365552&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004988%2Fabstract%3Frss%3Dyes Conclusions: Although anxiety is associated with an increased risk of death, the presence of anxiety as comorbid disorder does not give an additional increase in the risk of death among patients with a depressive disorder. The increased mortality among patients with depression is not restricted to suicide and cardiovascular diseases, but associated with a broad range of death causes. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365552 Thu, 03 Nov 2011 23:29:31 +0100 5365552 http://www.medworm.com/index.php?rid=5365551&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004666%2Fabstract%3Frss%3Dyes Conclusions: The death of a parent is a risk factor for depressive symptoms and depressive episodes in children and adolescents two months after the death. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365551 Thu, 03 Nov 2011 23:29:31 +0100 5365551 http://www.medworm.com/index.php?rid=5365550&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004642%2Fabstract%3Frss%3Dyes Conclusions: When considering how to tailor therapies for those experiencing depressive symptoms, health professionals should consider the interaction of stigma with coping strategies. Many individuals can build on existing relationships and personal strengths to develop resilience, some however need to first relinquish the expectation of having sufficient pre-existing resilience within themselves. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365550 Thu, 03 Nov 2011 23:29:31 +0100 5365550 http://www.medworm.com/index.php?rid=5365549&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004654%2Fabstract%3Frss%3Dyes Conclusions: There are statistically significant seasonal variations of completed suicide for both men and women in Shandong, China. Differences exist between residence (urban/rural), age groups and suicide methods. Results appear to support a sociological explanation of suicide seasonality. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365549 Thu, 03 Nov 2011 23:29:31 +0100 5365549 http://www.medworm.com/index.php?rid=5365548&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004599%2Fabstract%3Frss%3Dyes Abstract: Emotion biases feature prominently in cognitive theories of depression and are a focus of psychological interventions. However, there is presently no stable neurocognitive marker of altered emotion–cognition interactions in depression. One reason may be the heterogeneity of major depressive disorder. Our aim in the present study was to find an emotional bias that differentiates patients with melancholic depression from controls, and patients with melancholic from those with non-melancholic depression. We used a working memory paradigm for emotional faces, where two faces with angry, happy, neutral, sad or fearful expression had to be retained over one second. Twenty patients with melancholic depression, 20 age-, education- and gender-matched control participants and 20 patients... Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365548 Thu, 03 Nov 2011 23:29:31 +0100 5365548 http://www.medworm.com/index.php?rid=5365547&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS016503271100454X%2Fabstract%3Frss%3Dyes Conclusions: BP diagnosis is the most significant predictor for psychosis in mood disorders. Non-psychotic mood episodes in PMD patients may be characterized by a distinctive symptom profile and, possibly, a different response to treatment. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365547 Thu, 03 Nov 2011 23:29:31 +0100 5365547 http://www.medworm.com/index.php?rid=5365546&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004551%2Fabstract%3Frss%3Dyes Conclusions: Using available factors, model discrimination did not reach an acceptable level i.e. 70% of presenteeism cases successfully classified. This highlighted the contribution of unmeasured factors to presenteeism behavior. Future research should explore the relative importance of psychosocial work environment and personality factors such as work demands, effort/reward imbalance and conscientiousness. The identified associations between socio-demographic, financial and health factors on work attendance behaviors could inform disease management guidelines for employers via recognition of employees at risk of presenteeism. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365546 Thu, 03 Nov 2011 23:29:31 +0100 5365546 http://www.medworm.com/index.php?rid=5365545&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004514%2Fabstract%3Frss%3Dyes Conclusions: Auxiliary treatment is usual among patients receiving short- and long-term therapies, and apparently becomes common shortly after the start of treatment. Auxiliary treatment can be used as an outcome measure indicating the need for treatment, should be monitored clinically and considered when interpreting the results of effectiveness studies. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365545 Thu, 03 Nov 2011 23:29:31 +0100 5365545 http://www.medworm.com/index.php?rid=5365544&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004526%2Fabstract%3Frss%3Dyes The objective was to investigate the integrity of white matter tracts in subjects with LLD compared to similar aged healthy individuals using diffusion tensor imaging (DTI).Methods: Sixty eight subjects (30 healthy individuals, 38 depressed) underwent DTI on a 3T scanner following clinical and cognitive assessment. An automated tract-based spatial statistics (TBSS) method was used to derive estimates of fractional anisotropy (FA) and mean diffusivity (MD) for each subject. Group effects and correlations with clinical features on DTI parameters were examined.Results: Compared to controls, uncorrected maps revealed patients with LLD exhibited lower FA in frontal, temporal and midbrain regions relative to older healthy subjects (p (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365544 Thu, 03 Nov 2011 23:29:31 +0100 5365544 http://www.medworm.com/index.php?rid=5365543&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004356%2Fabstract%3Frss%3Dyes Conclusion: Women treated with SSRIs during pregnancy, mainly at high-dose, had an increased risk of preterm birth compared to healthy women of similar age and parity who were not exposed to SSRI during pregnancy. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365543 Thu, 03 Nov 2011 23:29:31 +0100 5365543 http://www.medworm.com/index.php?rid=5365542&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004319%2Fabstract%3Frss%3Dyes Conclusions: Treatment of OCD with comorbid depression should focus on amelioration of OCD symptoms. When OCD treatment is successful, depressive symptoms are likely to ameliorate as well. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365542 Thu, 03 Nov 2011 23:29:31 +0100 5365542 http://www.medworm.com/index.php?rid=5365541&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004320%2Fabstract%3Frss%3Dyes Conclusions: Our data suggest that aberrant processes of neurodevelopment may contribute to the etiology of bipolar I disorder. The field is open for further research using modern instruments and designs in order to identify potential biological markers for bipolar disorder (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365541 Thu, 03 Nov 2011 23:29:31 +0100 5365541 http://www.medworm.com/index.php?rid=5365540&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004290%2Fabstract%3Frss%3Dyes Conclusion: Although lower than previously reported, psychological morbidity is prevalent six months after a cancer diagnosis and emphasises the need for routine psychosocial assessment throughout the cancer trajectory to identify those at increased risk or in need of immediate intervention. Physical activity, smoking cessation and coping skills training interventions warrant further exploration. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365540 Thu, 03 Nov 2011 23:29:30 +0100 5365540 http://www.medworm.com/index.php?rid=5365539&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004204%2Fabstract%3Frss%3Dyes Conclusion: Dominant cyclothymic, but also depressive and anxious temperament, seem to be negative predictors for the course of illness in alcohol dependence. Regarding positive long term outcome specific evidence based medical treatment approaches are needed for these patients. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365539 Thu, 03 Nov 2011 23:29:30 +0100 5365539 http://www.medworm.com/index.php?rid=5365538&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004216%2Fabstract%3Frss%3Dyes Conclusions: Hospitalized hypertensives, more frequently satisfied criteria for Symptomatic Subsyndromal Depression. These milder affective forms are probably directly linked to the presence of hypertension, rather than being indirectly associated to physical impairment or to higher prevalence of other cardiovascular risk factors. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365538 Thu, 03 Nov 2011 23:29:30 +0100 5365538 http://www.medworm.com/index.php?rid=5365537&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004228%2Fabstract%3Frss%3Dyes Conclusions: Sub-clinical depression, major depression and bipolar depression are widespread among HIV patients receiving ART. Integration of mental health services into HIV Care is desperately needed. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365537 Thu, 03 Nov 2011 23:29:30 +0100 5365537 http://www.medworm.com/index.php?rid=5365536&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004265%2Fabstract%3Frss%3Dyes Conclusions: At least some MDD patients responding to duloxetine might exhibit a peculiar ERG pattern, hypothetically indicating a specific biological background. If confirmed by larger-sampled studies, these results might shed further light in the understanding of the biological determinants of different subtypes of depression, ideally showing alternative patters of response upon different treatment interventions. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365536 Thu, 03 Nov 2011 23:29:30 +0100 5365536 http://www.medworm.com/index.php?rid=5365535&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004186%2Fabstract%3Frss%3Dyes Conclusions: MADRS-S is a suitable tool for following patients' symptoms on a regular basis over time and may also be used to compensate for bias in physicians' ratings in drug trials. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365535 Thu, 03 Nov 2011 23:29:30 +0100 5365535 http://www.medworm.com/index.php?rid=5365534&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004198%2Fabstract%3Frss%3Dyes Conclusions: Reduced GM volumes in critical cortical areas of suicidal patients could be a biological correlate of an impaired ability to associate choices and outcomes and to plan goal-directed behaviors based on a lifetime historical perspective, which, coupled with mood-congruent depressive cognitive distortions, could lead to more hopelessness and suicide. Lithium could exert its specific therapeutic effect on suicide by acting in the same areas. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365534 Thu, 03 Nov 2011 23:29:30 +0100 5365534 http://www.medworm.com/index.php?rid=5365533&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004174%2Fabstract%3Frss%3Dyes Conclusions: These results indicate that depression during pregnancy and postpartum is associated with a large range of psychiatric disorders. The high frequency of psychiatric comorbidities, the elevated use of any substances and the high rate of unmet needs should be kept in mind when considering the management of depression during pregnancy and postpartum. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365533 Thu, 03 Nov 2011 23:29:30 +0100 5365533 http://www.medworm.com/index.php?rid=5365532&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003880%2Fabstract%3Frss%3Dyes Conclusions: Our findings showed that alexithymia scarcely contributed to complicated grief compared to depression and that the contribution ratio in the high risk group was lower than that in the low risk group. The contribution of the latent variable of psychological distress to complicated grief and depression was lower in the high risk group than in the low risk group. The lack of a correlation between alexithymia and complicated grief might indicate that there are different mechanisms underlying the symptoms of alexithymia and complicated grief. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365532 Thu, 03 Nov 2011 23:29:30 +0100 5365532 http://www.medworm.com/index.php?rid=5365531&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS016503271100396X%2Fabstract%3Frss%3Dyes Abstract: Objective: Serum cholesterol was reported to be associated with depressed mood, but the studies conducted among household population are rare.Methods: We used the data of 4115 men and 4275 women aged 18 or older, who completed a depression screening interview and had blood collected as a part of the National Health and Nutrition Examination Survey, 2005–2008. The serum concentrations of total cholesterol, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were gender-specifically categorized into lower, intermediate, and upper quartiles. Depression was measured using the Patient Health Questionnaire, a 9-item screening instrument asking about the frequency of depression symptoms over the past 2weeks.Results: After adjustment for socio-... Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365531 Thu, 03 Nov 2011 23:29:30 +0100 5365531 http://www.medworm.com/index.php?rid=5365530&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004009%2Fabstract%3Frss%3Dyes Conclusions: Despite the exploratory nature of this study, the results suggest that the popular notion of ‘Chinese somatization’ should not be over-generalized. Our findings also imply that there may be important differences in the cultural understanding of depression and anxiety in both Chinese and ‘Western’ contexts. Future studies should seek to unpack potential cultural explanations for why Euro-Canadian outpatients may emphasize somatic symptoms in the presentation of anxiety to a greater degree than Chinese outpatients. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365530 Thu, 03 Nov 2011 23:29:30 +0100 5365530 http://www.medworm.com/index.php?rid=5365529&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004022%2Fabstract%3Frss%3Dyes Conclusions: The additional diagnosis of dysthymia in Chinese women with recurrent MDD defines a meaningful and potentially important subtype. We conclude that in some circumstances it is possible to distinguish double depression from recurrent MDD. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365529 Thu, 03 Nov 2011 23:29:30 +0100 5365529 http://www.medworm.com/index.php?rid=5365528&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004046%2Fabstract%3Frss%3Dyes Conclusions: Neuroticism acts as a risk factor for MDD in Chinese women, as it does in the West and may particularly predispose to comorbidity with anxiety disorders. Cultural factors may have an important effect on its measurement. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365528 Thu, 03 Nov 2011 23:29:30 +0100 5365528 http://www.medworm.com/index.php?rid=5365527&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004058%2Fabstract%3Frss%3Dyes Conclusions: More severe SLEs are more strongly associated with MDD. These results support the involvement of psychosocial adversity in the etiology of MDD in China. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365527 Thu, 03 Nov 2011 23:29:30 +0100 5365527 http://www.medworm.com/index.php?rid=5365526&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004071%2Fabstract%3Frss%3Dyes Conclusions: Early AAO in MDD may be an index of a more severe, highly comorbid and familial disorder. Our findings indicate that the features of MDD in China are similar to those reported elsewhere in the world. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365526 Thu, 03 Nov 2011 23:29:29 +0100 5365526 http://www.medworm.com/index.php?rid=5365525&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004095%2Fabstract%3Frss%3Dyes Conclusions: By making minor modifications to the PMTS-O we have ensured that all criteria for the DSM-IV definition of PMDD are now represented in the PMTS-OR. The new PMTS-VAS mirrors the PMTS-OR but now also captures the severity of self rated symptoms. These scales are simple to complete for both clinicians and clients, and are reliable, valid and sensitive to change. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365525 Thu, 03 Nov 2011 23:29:29 +0100 5365525 http://www.medworm.com/index.php?rid=5365524&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004125%2Fabstract%3Frss%3Dyes Conclusion: The study suggested that the effect of younger age at last childbirth on the risk of possible postpartum depression development was higher for women who gave birth through C-section compared to those with vaginal delivery. Despite the stressful and crisis conditions existing in Armenia over the past 2 decades the prevalence of possible postpartum depression does not differ much from that in other societies. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365524 Thu, 03 Nov 2011 23:29:29 +0100 5365524 http://www.medworm.com/index.php?rid=5365523&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003624%2Fabstract%3Frss%3Dyes Conclusion: Our results indicate that Japan's MTD seems to be occurring in many other countries, and that the present ICD/DSM criteria may not be sufficient to diagnose MTD. Therefore, it could be an important candidate for a new international diagnostic criterion as a subtype of depression. A clear diagnostic framework and consensus on the interventions to treat MTD would be valuable. Further clinical, psychopathological and international epidemiological studies are needed to confirm our preliminary findings of MTD. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365523 Thu, 03 Nov 2011 23:29:29 +0100 5365523 http://www.medworm.com/index.php?rid=5365522&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711000930%2Fabstract%3Frss%3Dyes Conclusions: The specific effect on persistent depression increases the significance of this G×E for public health. Research that does not distinguish persistent course may underestimate G×E effects and account for some replication failures in G×E research. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365522 Thu, 03 Nov 2011 23:29:29 +0100 5365522 http://www.medworm.com/index.php?rid=5365521&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003892%2Fabstract%3Frss%3Dyes Conclusions:: Most of the earthquake survivors experienced anxiety disorders at follow-up but not high levels of PTSD or depression. Clinical interviews identified resilient factors that may have helped these subjects maintain functional and adaptive capacities despite clinical elevations on the SCL-90. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365521 Thu, 03 Nov 2011 23:29:29 +0100 5365521 http://www.medworm.com/index.php?rid=5365520&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004630%2Fabstract%3Frss%3Dyes Abstract: Background: It has recently been hypothesized that bipolar disorders are associated with accelerated aging. Telomere dysfunction, a biomarker of aging, is determined by the load of short telomeres, rather than by the mean telomere length. To our knowledge, the load of short telomeres has not been reported in any psychiatric disorder. The aims of the study were to examine the load of short telomeres and the mean telomere length and their relationships with illness duration and lifetime number of depressive episodes in bipolar II disorder (BD-II).Methods: Twenty-eight patients (mean age=34.8±7.7) with a DSM-IV diagnosis of BD-II and 28 healthy control subjects (mean age=34.8±9.2) matched for age, sex, and education participated. The load of short telomeres (percentage of telomere... Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365520 Thu, 03 Nov 2011 23:29:29 +0100 5365520 http://www.medworm.com/index.php?rid=5365519&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003910%2Fabstract%3Frss%3Dyes Abstract: Introduction: Borderline personality disorder (BPD) is typically characterized by severe affective dysregulation leading to impulsive behaviors. Accordingly, preliminary data suggest the hypothesis that BPD patients could have a specific and altered pattern of subjective emotional response to stimuli. The nature of the emotional response in BPD can be compared with other affective disorders and provide further insight on the nosological proximity with other psychiatric disorders.Methods: Subjective emotional response was investigated in 19 patients with DSM-IV BPD with no current depressive episode and in 19 healthy control subjects by using the International Affective Picture System (IAPS). The intensity of arousal, valence and dominance was rated in response to 60 images catego... Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365519 Thu, 03 Nov 2011 23:29:29 +0100 5365519 http://www.medworm.com/index.php?rid=5365518&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711004137%2Fabstract%3Frss%3Dyes Conclusions: This study confirms that the cyclothymic dimension of the bipolar spectrum is linked to creativity, and this link is likely to result from increased involvement into pleasurable activities, including creative ones. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365518 Thu, 03 Nov 2011 23:29:29 +0100 5365518 http://www.medworm.com/index.php?rid=5365517&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS016503271100022X%2Fabstract%3Frss%3Dyes Conclusions: HA is indisputably associated with the risk and treatment response in depression. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365517 Thu, 03 Nov 2011 23:29:29 +0100 5365517 http://www.medworm.com/index.php?rid=5365516&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711000292%2Fabstract%3Frss%3Dyes Conclusions: Non-depressed people with insomnia have a twofold risk to develop depression, compared to people with no sleep difficulties. Thus, early treatment programs for insomnia might reduce the risk for developing depression in the general population and be considered a helpful general preventive strategy in the area of mental health care. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365516 Thu, 03 Nov 2011 23:29:29 +0100 5365516 http://www.medworm.com/index.php?rid=5365515&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711000668%2Fabstract%3Frss%3Dyes Conclusion: Several catatonia rating scales are proposed to detect the catatonic syndrome and to evaluate treatment response. BFCRS, NCRS and BCRS are reliable for use in variable populations in which catatonia is prevalent. The BFCRS is preferred for routine use, because of its validity and reliability, and its ease of administration. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365515 Thu, 03 Nov 2011 23:29:28 +0100 5365515 http://www.medworm.com/index.php?rid=5365514&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711005994%2Fabstract%3Frss%3Dyes (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5365514 Thu, 03 Nov 2011 23:29:28 +0100 5365514 http://www.medworm.com/index.php?rid=5211412&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711002175%2Fabstract%3Frss%3Dyes Conclusion: Results suggest that fictional suicide portrayals in the media may have a deleterious impact on viewers, and such impacts do not appear to be limited to people having a clinical profile of mental disorders, as previously assumed by researchers in the field. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211412 Tue, 13 Sep 2011 03:39:47 +0100 5211412 http://www.medworm.com/index.php?rid=5211411&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003193%2Fabstract%3Frss%3Dyes Conclusions: Hippocampal volume loss in first episode depression is consistent with a neurodevelopmental model of depression, advocating hippocampal structure as a potential diagnostic neurobiomarker for depression. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211411 Tue, 13 Sep 2011 03:39:47 +0100 5211411 http://www.medworm.com/index.php?rid=5211410&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711002862%2Fabstract%3Frss%3Dyes Conclusions: The present investigation does not support the association between elevated serum-TSH concentrations and severe mood dysregulation in youths. However, these findings should be confirmed in future large-scale studies. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211410 Tue, 13 Sep 2011 03:39:47 +0100 5211410 http://www.medworm.com/index.php?rid=5211409&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711002850%2Fabstract%3Frss%3Dyes Conclusions: Reducing stigma may help to improve the first aid that people with mental health problems can receive from young people who are close to them. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211409 Tue, 13 Sep 2011 03:39:47 +0100 5211409 http://www.medworm.com/index.php?rid=5211408&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711002734%2Fabstract%3Frss%3Dyes Conclusions: The long-term efficacy of PDT (with or without antidepressants) seemed to be comparable with other psychotherapies for depression. But the high recurrence rate urges us to shift the focus of depression treatment to improving long-term outcome and to the prevention of recurrence, in particular for young women and patients with residual symptoms of depression. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211408 Tue, 13 Sep 2011 03:39:47 +0100 5211408 http://www.medworm.com/index.php?rid=5211407&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711002722%2Fabstract%3Frss%3Dyes We examined changes in anxiety and depression over a 12-month period and the demographic and clinical correlates of change scores using an intra-individual approach in patients treated with percutaneous coronary intervention (PCI).Methods: Consecutive PCI patients (N=715) completed the Hospital Anxiety and Depression Scale (HADS) at baseline and at 12months post-PCI. Individual change scores were calculated and in secondary analysis, three categories of change were identified (i.e., stable, improved, and deteriorated anxiety or depression).Results: The mean individual change was −.16 (±3.0) for anxiety and −.02 (±2.8) for depression. In linear regression analysis, baseline anxiety levels (B=−.25, 95%CI[−.30 to −.20], p= (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211407 Tue, 13 Sep 2011 03:39:47 +0100 5211407 http://www.medworm.com/index.php?rid=5211406&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711002643%2Fabstract%3Frss%3Dyes This study investigated the efficacy and safety of tDCS given with a fronto-extracephalic (F-EX) montage.Methods: 2mA tDCS was administered for 20min every weekday over four weeks in 11 participants with a Major Depressive Episode who had previously shown inadequate response to, or relapsed following, a course of BF tDCS. For F-EX tDCS the anode was placed on the left dorsolateral prefrontal cortex and the cathode on the right upper arm. Depression severity and neuropsychological function were assessed before and after the treatment course. Antidepressant response was compared across an equivalent treatment period for both montages.Results: F-EX tDCS was shown to be safe and well tolerated. Depression ratings improved after acute treatment on the Montgomery Åsberg Depression Rating Scale ... Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211406 Tue, 13 Sep 2011 03:39:47 +0100 5211406 http://www.medworm.com/index.php?rid=5211405&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711002631%2Fabstract%3Frss%3Dyes Conclusions: We found high rates of CG in a group of psychiatric outpatients with chronic MDD, suggesting that patients with depression should be routinely screened for CG. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211405 Tue, 13 Sep 2011 03:39:47 +0100 5211405 http://www.medworm.com/index.php?rid=5211404&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711002564%2Fabstract%3Frss%3Dyes Abstract: Background: To study the association between lipid-metabolism and depressive symptoms, genetic polymorphisms in serotonin transporter linked promoter region (5-HTTLPR) and fatty acid synthase gene (FASN) were investigated.Method: A cross-sectional study was conducted on 177 women (n=166) and men (n=15) recruited from workers in a hospital and nursing homes in Japan. Depressive symptoms were assessed by the Center for Epidemiologic Studies Depression (CES-D) scale and perceived psychological stress was measured using visual analogue scale (VAS). The genotypes of 5-HTTLPR (insertion/deletion; L/S), and FASN (Val1483Ile) were determined by the PCR methods. Linear regression analysis was performed, in which CES-D scores served as a dependent variable, and VAS scores, gene polymorphis... Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211404 Tue, 13 Sep 2011 03:39:47 +0100 5211404 http://www.medworm.com/index.php?rid=5211403&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711002539%2Fabstract%3Frss%3Dyes Conclusions: This study provides evidence for the PHQ-2 as a reliable and valid screening tool for depressive symptoms among a randomly recruited community sample in Hong Kong. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211403 Tue, 13 Sep 2011 03:39:47 +0100 5211403 http://www.medworm.com/index.php?rid=5211402&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003041%2Fabstract%3Frss%3Dyes Conclusions: The results indicate that individuals with bipolar disorder tend to appraise activated, energetic internal states in opposing or conflicting ways, interpreting these states as both extremely positive and extremely negative. This may lead to contradictory attempts to regulate these states, which may in turn contribute to mood swing symptoms. Psychological therapy for mood swings and bipolar disorder should address extreme and conflicting appraisals of mood states. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211402 Tue, 13 Sep 2011 03:39:47 +0100 5211402 http://www.medworm.com/index.php?rid=5211401&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711002801%2Fabstract%3Frss%3Dyes Conclusions: Negative and loss-related SLE are common in BPD subjects, occur in the year preceding the first episodes of depression and mania and are less common in childhood or after the onset of the disorder. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211401 Tue, 13 Sep 2011 03:39:47 +0100 5211401 http://www.medworm.com/index.php?rid=5211400&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711002813%2Fabstract%3Frss%3Dyes Conclusions: These cases suggest that there is an association between delusional disorder and affective disorder which goes beyond the occurrence of depressive symptoms in the disorder. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211400 Tue, 13 Sep 2011 03:39:47 +0100 5211400 http://www.medworm.com/index.php?rid=5211399&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711002692%2Fabstract%3Frss%3Dyes Conclusion: Though further investigations are necessary to confirm this data, our results suggest that CB2 cannabinoid receptor may play a role in BD. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211399 Tue, 13 Sep 2011 03:39:47 +0100 5211399 http://www.medworm.com/index.php?rid=5211398&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS016503271100214X%2Fabstract%3Frss%3Dyes Abstract: Background: Although sleepiness and fatigue are common symptoms in depressed patients, the relationships among sleepiness, fatigue and treatment of depression have not been fully elucidated. The main objective of this study was to investigate the therapeutic effects of a sedating antidepressant on sleepiness and fatigue in patients with depression.Methods: Forty-two depressed patients, who met DSM-IV diagnostic criteria, and 32 matched healthy controls participated in the baseline measurements. Sixteen of the depressed patients were treated with mirtazapine. At baseline, daytime sleepiness was assessed using the Epworth Sleepiness Scale (ESS) and Stanford Sleepiness Scale (SSS), and fatigue was assessed using the Fatigue Severity Scale (FSS) and Fatigue Impact Scale (FIS). During... Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211398 Tue, 13 Sep 2011 03:39:46 +0100 5211398 http://www.medworm.com/index.php?rid=5211397&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS016503271100262X%2Fabstract%3Frss%3Dyes Discussion: These findings highlight the importance of disrupted sleep patterns in the course of bipolar illness. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211397 Tue, 13 Sep 2011 03:39:46 +0100 5211397 http://www.medworm.com/index.php?rid=5211396&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711002011%2Fabstract%3Frss%3Dyes Abstract: Objective: In order to explore the relationships of fronto-limbic dysfunction with the clinical features of borderline personality disorder (BPD), the authors investigated brain electrophysiological activity in BPD patients following stimulation with emotionally arousing images.Methods: Seventeen non-medicated patients with borderline personality disorder were studied with magneto-encephalography. Regional cortical activities were obtained by minimum norm estimate (MNE) of steady-state visual evoked fields (ssVEFs). Linear regression models were conducted to explore clinical correlates of brain activity.Results: Although no interaction group×picture category×brain region was found, a significant interaction group×brain region appeared for orbito-frontal cortex (OFC). BPD patie... Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211396 Tue, 13 Sep 2011 03:39:46 +0100 5211396 http://www.medworm.com/index.php?rid=5211395&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003089%2Fabstract%3Frss%3Dyes Conclusions: These results suggest that CP patients experience an increased risk of DD compared to non-CP patients during a three year follow-up period. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211395 Tue, 13 Sep 2011 03:39:46 +0100 5211395 http://www.medworm.com/index.php?rid=5211394&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711002795%2Fabstract%3Frss%3Dyes Conclusion: Type D identifies persons with severely increased risk for mental distress, major psychosocial stressors and increased health care utilization. As a frequent disposition, Type D is assumed to be of high relevance for health care. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211394 Tue, 13 Sep 2011 03:39:46 +0100 5211394 http://www.medworm.com/index.php?rid=5211393&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003284%2Fabstract%3Frss%3Dyes Conclusions: We present three conclusions: we show, for the first time, evidence for a deficit in hemispheric integration in EDs. This implies that EDs may be a disconnection syndrome; alexithymia characterizes women with EDs and members of their family; depression is manifested differently in AN-R, than in women who binge/purge. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211393 Tue, 13 Sep 2011 03:39:46 +0100 5211393 http://www.medworm.com/index.php?rid=5211392&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003260%2Fabstract%3Frss%3Dyes Conclusions: Results from the current study demonstrate that longer term administration of SSRIs alters aspects of mood and personality in the absence of disorder. This suggests that these agents have effects on basic psychological processes that may in turn form the basis of their therapeutic efficacy. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211392 Tue, 13 Sep 2011 03:39:46 +0100 5211392 http://www.medworm.com/index.php?rid=5211391&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711002758%2Fabstract%3Frss%3Dyes Conclusions: These findings provide new insights into how SLEs affect panic symptoms in adults with PD/PDA in that household-related SLEs, such as serious family arguments, and work-related SLEs, such as being fired, put some adults at risk for worsened panic symptoms within 12-weeks of the event. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211391 Tue, 13 Sep 2011 03:39:46 +0100 5211391 http://www.medworm.com/index.php?rid=5211390&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711002746%2Fabstract%3Frss%3Dyes Conclusions: Comorbid mental disorders pose a high risk for disability pension. Other independent predictors of work disability include socio-demographic, clinical, work-related, and treatment factors, but not health behavior. More attention should be paid to work-related factors in order to prevent chronic work disability. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211390 Tue, 13 Sep 2011 03:39:46 +0100 5211390 http://www.medworm.com/index.php?rid=5211389&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS016503271100276X%2Fabstract%3Frss%3Dyes Conclusion: Seasonal variations of personal and behavioral characteristics, combined with social activities, might also play very important roles in suicide seasonality. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211389 Tue, 13 Sep 2011 03:39:46 +0100 5211389 http://www.medworm.com/index.php?rid=5211388&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711002783%2Fabstract%3Frss%3Dyes Conclusion: Overall, while many methods used in the ED to assess suicidal and parasuicidal patients have strong psychometric properties, there is little clinical evidence supporting their use. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211388 Tue, 13 Sep 2011 03:39:46 +0100 5211388 http://www.medworm.com/index.php?rid=5211387&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711002667%2Fabstract%3Frss%3Dyes Conclusions: Suicidal thoughts are considered to be as disabling as alcohol dependence and severe asthma. The mental distress involved in non-fatal suicide attempts is thought to be comparable in disability to heroin dependence and initial stage Parkinson's. These results demonstrate the severity of suicidality. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211387 Tue, 13 Sep 2011 03:39:46 +0100 5211387 http://www.medworm.com/index.php?rid=5211386&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003296%2Fabstract%3Frss%3Dyes This study aimed to investigate one-year outcomes in suicide attempters aged 70+, and to identify predictors of these outcomes.Methods: 101 persons (mean age 80) who were hospitalized after a suicide attempt were interviewed at baseline and followed for one year by record linkage. Face-to-face interviews were carried out with 71% of those who were alive after one year (60 out of 85). Outcome measures included major/minor depression, Montgomery–Asberg Depression Rating Scale (MADRS) score, repeat non-fatal/fatal suicidal behavior and all-cause mortality.Results: One half (52%) of all those who were interviewed scored (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211386 Tue, 13 Sep 2011 03:39:46 +0100 5211386 http://www.medworm.com/index.php?rid=5211385&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003582%2Fabstract%3Frss%3Dyes Conclusions: Querying individuals on desire for death has the same value as assessing suicidal ideation to examine risk for suicide attempt. A combination of desire for death and suicidal ideation is the best predictor for suicide attempts. This is of high clinical relevance since we suggest that desire for death should be included as a potential clinical marker of suicidality in clinical assessments. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211385 Tue, 13 Sep 2011 03:39:46 +0100 5211385 http://www.medworm.com/index.php?rid=5211384&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003065%2Fabstract%3Frss%3Dyes Conclusions: Risk of suicide is increased in nurses, physicians, dentists and pharmacists in Denmark. This is not reflected in excess psychiatric service contact. Ready access to medicinal drugs may influence risk in nurses, physicians and pharmacists. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211384 Tue, 13 Sep 2011 03:39:46 +0100 5211384 http://www.medworm.com/index.php?rid=5211383&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003223%2Fabstract%3Frss%3Dyes Abstract: Structural deficiencies within the medial prefrontal cortex have been shown in anxiety-related psychiatric disorders such as panic disorder, post traumatic stress disorder and obsessive compulsive disorder. In healthy subjects, trait anxiety as the individual's disposition to experience anxiety-relevant feelings or thoughts has been shown to be a risk factor for psychiatric disorders. We aimed at exploring the structural correlates of trait anxiety in normal participants. We acquired high-resolution MRI scans from 34 subjects and used FreeSurfer to obtain a measure of cortical thickness. We correlated cortical thickness with self-rated trait anxiety in a whole brain analysis. Automatic subcortical segmentations of the FreeSurfer pipeline were used to relate nucleus accumbens (NAc... Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211383 Tue, 13 Sep 2011 03:39:46 +0100 5211383 http://www.medworm.com/index.php?rid=5211382&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003119%2Fabstract%3Frss%3Dyes Conclusions: Targeting various material, psychosocial, and behavioural factors, as well as chronic diseases may help to reduce educational differences in depression and anxiety in the general population. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211382 Tue, 13 Sep 2011 03:39:46 +0100 5211382 http://www.medworm.com/index.php?rid=5211381&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003600%2Fabstract%3Frss%3Dyes Conclusions: In this initial psychometric evaluation, the FAsD demonstrated good reliability, validity, and factor structure. This questionnaire may be a useful tool for evaluating treatment interventions that focus specifically on fatigue associated with depression. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211381 Tue, 13 Sep 2011 03:39:46 +0100 5211381 http://www.medworm.com/index.php?rid=5211380&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003594%2Fabstract%3Frss%3Dyes Conclusions: Both MDE and antidepressant medication use are associated with a modest increase in weight in people under 65. These results may be useful for physicians and other health professionals in planning dietary and weight-management regimens for depressed patients. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211380 Tue, 13 Sep 2011 03:39:46 +0100 5211380 http://www.medworm.com/index.php?rid=5211379&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003545%2Fabstract%3Frss%3Dyes Abstract: Background: Despite an apparent high interest in predictive genetic testing for common multifactorial disorders, few data describe anticipated health behaviour as a consequence of such testing.Methods: A large population-based public survey with community dwelling adults (N=1046) ascertained through random digit dialling. Attitudes were assessed via structured interviews.Results: Intention to start therapies or courses to learn to develop better strategies to cope with stress (80%) was significantly and positively associated with self-estimation of risk for major depressive disorder as higher than average (ß=0.12, p=0.001); endorsement of family environment as a causal attribution (ß=0.11, p (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211379 Tue, 13 Sep 2011 03:39:46 +0100 5211379 http://www.medworm.com/index.php?rid=5211378&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003405%2Fabstract%3Frss%3Dyes Conclusions: Functional disconnection between limbic and frontal brain regions could be demonstrated using structural equation modeling. The interpretation of these findings could be that there is an emotional processing bias with disconnection bilaterally between amygdala to orbitofrontal cortices and in addition a right disconnection between amygdala and ACC as well as between ACC and prefrontal cortex possibly in line with a more prominent role for the right hemisphere in emotion processing. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211378 Tue, 13 Sep 2011 03:39:46 +0100 5211378 http://www.medworm.com/index.php?rid=5211377&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003363%2Fabstract%3Frss%3Dyes Conclusions: PHQ-9 is a valid and reliable depression screening tool for drug and alcohol users. The brevity and ease of administration of self-completed questionnaires make them useful clinical tools in addiction services commonly encountering a high prevalence of depression. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211377 Tue, 13 Sep 2011 03:39:46 +0100 5211377 http://www.medworm.com/index.php?rid=5211376&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003181%2Fabstract%3Frss%3Dyes Conclusions: Early recognition and treatment of disturbances of the sleep–wake cycle may be important for treatment and prevention of recurrence of depression. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211376 Tue, 13 Sep 2011 03:39:46 +0100 5211376 http://www.medworm.com/index.php?rid=5211375&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003156%2Fabstract%3Frss%3Dyes The objective of this study was a health economic evaluation of SSTR based on a cost effectiveness analysis (CEA).Methods: GAP2 was a randomized controlled study with 148 patients. In an intention to treat (ITT) analysis direct treatment costs for study duration (SD) and total time in hospital (TTH; enrolment to discharge) were calculated based on daily hospital charges followed by a CEA to calculate cost expenditure per remitted patient.Results: Treatment costs in SSTR compared to TAU were significantly lower for SD (SSTR: 10 830 €±8 632 €, TAU: 15 202 €±12 483 €; p=0.026) and did not differ significantly for TTH (SSTR: 21 561 €±16 162 €; TAU: 18 248 €±13 454; p=0.208). CEA revealed that the costs per remission in SSTR were significantly lower for SD (SSTR: 20 035 €±1... Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211375 Tue, 13 Sep 2011 03:39:46 +0100 5211375 http://www.medworm.com/index.php?rid=5211374&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003144%2Fabstract%3Frss%3Dyes Conclusion: Home dwelling older patients with major depressive disorder, their practitioners and their informal carers have different perceptions of the older patients unmet needs.Practitioners should be aware of the negative impact of depression severity on reaching agreement regarding unmet needs and its possible consequences for mutual goal setting and compliance. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211374 Tue, 13 Sep 2011 03:39:46 +0100 5211374 http://www.medworm.com/index.php?rid=5211373&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003132%2Fabstract%3Frss%3Dyes Conclusions: Early remitted patients have a better “quality” of remission. Late remission is associated with residual symptoms more related to core depressive symptoms. Residual symptoms in early remitted patients may constitute a new target for the treatment of depression. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211373 Tue, 13 Sep 2011 03:39:46 +0100 5211373 http://www.medworm.com/index.php?rid=5211372&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003120%2Fabstract%3Frss%3Dyes Conclusions: Several important therapeutic factors were identified in multi-family therapy groups for depression. These factors help to gain understanding into the processes, which should be emphasized in treatment and ought to be explored in future outcome and process research. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211372 Tue, 13 Sep 2011 03:39:46 +0100 5211372 http://www.medworm.com/index.php?rid=5211371&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003090%2Fabstract%3Frss%3Dyes Abstract: Objectives: The involvement of an immune process in the pathophysiology of major depression disorder (MDD) was substantiated by studies demonstrating elevated levels of proinflammatory cytokines and prostaglandin E2 (PGE2). Cyclooxygenase-2 (COX-2) inhibitors lead to a reduced production of PGE2 and have been shown to improve depressive symptoms. We investigated the three immune parameters macrophage migration inhibitory factor (MIF), transforming growth factor-β (TGF-β) and soluble CD14 (sCD14) in a randomized, placebo-controlled trial of the COX-2 inhibitor celecoxib as add-on therapy in patients with MDD treated with reboxetine.Methods: Thirty-two patients with depression and 20 healthy controls participated in the study. The patients were treated with reboxetine and celecox... Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211371 Tue, 13 Sep 2011 03:39:46 +0100 5211371 http://www.medworm.com/index.php?rid=5211370&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003077%2Fabstract%3Frss%3Dyes Conclusions: Complaints of difficulty falling asleep increase the risk of incident depression in older men. Clarifying the mechanisms that underlie this association should become an international research priority, as they may contribute to guide interventions designed to decrease the burden of depression in later life. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211370 Tue, 13 Sep 2011 03:39:46 +0100 5211370 http://www.medworm.com/index.php?rid=5211369&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711003053%2Fabstract%3Frss%3Dyes Conclusions: The findings indicated a higher prevalence of depression symptoms among migrant workers comparing to general population reported by previous studies, identified possible factors associated with depression symptoms, and also explored relationships between these factors. Our study provides a model to understand mental health of Chinese internal migrant workers and to generate important research questions for the future. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211369 Tue, 13 Sep 2011 03:39:45 +0100 5211369 http://www.medworm.com/index.php?rid=5211368&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711002837%2Fabstract%3Frss%3Dyes Conclusions: Expansion of antidepressant treatments in recent years has not changed the community prevalence of depression overall, but it has reduced the prevalence of more severe depression and suicidal ideations. The findings call for better targeting and more judicious use of antidepressants in cases of more severe depressive episodes which are more likely to respond to such treatments. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211368 Tue, 13 Sep 2011 03:39:45 +0100 5211368 http://www.medworm.com/index.php?rid=5211367&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711002825%2Fabstract%3Frss%3Dyes Abstract: Background: As the older population increases so does the number of older psychiatric patients. Elderly psychiatric patients manifest certain specific and unique characteristics. Different subtypes of depressive syndromes exist in late-life depression, and many of these are associated with cognitive impairment.Materials and methods: A total of 109 depressive patients and 30 normal subjects matched by age and educational level were evaluated using a neuropsychiatric interview and an extensive neuropsychological battery. Depressive patients were classified into four different groups by SCAN 2.1 (schedules for clinical assessment in Neuropsychiatry): major depression disorder (n: 34), dysthymia disorder (n: 29), subsyndromal depression (n: 28), and depression due to mild dementia of... Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211367 Tue, 13 Sep 2011 03:39:45 +0100 5211367 http://www.medworm.com/index.php?rid=5211366&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS016503271100303X%2Fabstract%3Frss%3Dyes Conclusions: Dysthymic disorder was the most common depressive disorder. Low maternal education, low SES, dysfunctional interaction with the father, anxiety, and low self-esteem, which were all associated with depression, may be the target of interventions for prevention and treatment of depression. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211366 Tue, 13 Sep 2011 03:39:45 +0100 5211366 http://www.medworm.com/index.php?rid=5211365&cid=s_38489_25_f&fid=38489&url=http%3A%2F%2Fwww.jad-journal.com%2Farticle%2FPIIS0165032711002709%2Fabstract%3Frss%3Dyes Conclusion: Low socioeconomic position is associated with onset of depression but not mild distress. Attributes of occupational class and household income may be respectively more relevant for the development of depression in men and women. (Source: Journal of Affective Disorders) Journal of Affective Disorders journals http://www.medworm.com/rss/comments.php?id=5211365 Tue, 13 Sep 2011 03:39:45 +0100 5211365