MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Journal of Allergy and Clinical Immunology' source. Sat, 20 Mar 2010 13:39:34 +0100 http://www.medworm.com/index.php?rid=3360145&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674910001740%2Fabstract%3Frss%3Dyes With regard to the December 2009 article entitled “Primary immunodeficiencies: 2009 update” (J Allergy Clin Immunol 2009;124:1161-78), corrections need to be made in Table V for the rows relevant to AD hyper-IgE and AR hyper-IgE (TYK2 deficiency). In addition, following a recent publication, the authors would like to take this opportunity to add NCF4: p40phox to the list of gene defects for Autosomal CGDs. A corrected version of the table can be found below. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360145 Mon, 01 Mar 2010 00:00:00 +0100 3360145 http://www.medworm.com/index.php?rid=3360144&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674910000035%2Fabstract%3Frss%3Dyes To the Editor: We are writing in reply to the comments of Farah et al regarding our findings published in the July issue of the Journal about the effects of obesity on asthma control in an urban population. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360144 Mon, 01 Mar 2010 00:00:00 +0100 3360144 http://www.medworm.com/index.php?rid=3360143&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674910000023%2Fabstract%3Frss%3Dyes To the Editor: We read with interest the article by Clerisme-Beaty et al in the July issue of the Journal. The authors highlight an important and increasingly common problem in the clinical management of asthma, particularly in urban and disadvantaged populations, an area in which the authors have considerable expertise. The impact that obesity has on asthma control and asthma severity has been researched by several groups and continues to be debated. The authors of this study, unlike others, did not find an association between asthma control and obesity. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360143 Mon, 01 Mar 2010 00:00:00 +0100 3360143 http://www.medworm.com/index.php?rid=3360133&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674910000084%2Fabstract%3Frss%3Dyes To the Editor: One of the most exciting findings recently in the pathophysiology of asthma is that mammalian chitinases might play an important role in the pathogenesis of asthma. Some researchers hypothesize that mammalian chitinases and a chitinase homologue might contribute to the pathogenesis of type 2 helper immune responses, which play an important role in asthma. Chitinases are enzymes that cleave chitin, a polysaccharide that is present in fungal cells, crustaceans, insects, and parasitic nematodes. Although chitin does not exist in human subjects, 2 chitinases, acidic mammalian chitinase (CHIA) and chitotriosidase (CHIT1), have been described in human subjects. A third protein, chitinase-like protein YKL-40 (also known as human cartilage glycoprotein 39 and chitinase 3–like 1 [... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360133 Mon, 01 Mar 2010 00:00:00 +0100 3360133 http://www.medworm.com/index.php?rid=3360129&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909027328%2Fabstract%3Frss%3Dyes To the Editor: Antimicrobial peptides (AMPs) are important effectors in cutaneous innate immunity as antibiotics and signaling molecules in the defense against microbes. The regulation of AMP expression and function in the skin is not completely understood. In the Journal, Gläser et al recently reported in an elegant study that the AMPs human β-defensin (HBD)–2, HBD3, ribonuclease (RNAse) 7, and psoriasin are induced in human keratinocytes on UV-B treatment in vitro and in vivo. In another recent study, expression of a different important AMP in skin—cathelicidin—was only enhanced after UV-B treatment in vivo, whereas in cultured primary human epidermal keratinocytes (NHEKs), no induction of cathelicidin after UV-B irradiation was observed. This observation could not be conclusive... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360129 Mon, 01 Mar 2010 00:00:00 +0100 3360129 http://www.medworm.com/index.php?rid=3360128&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS009167490902733X%2Fabstract%3Frss%3Dyes To the Editor: Host response against infectious challenge is typically mediated by specialized subsets of CD4+ effector TH cells. TH1 cells producing IFN-γ mediate cellular immunity against intracellular pathogens, whereas TH2 cells producing IL-4 and IL-13 mediate humoral immunity against parasites and helminths. TH17 cells producing IL-17 confer early protection against pathogenic insult in epithelial surfaces by inducing neutrophil-mediated immune responses and enhanced production of antimicrobial peptides (AMPs) such as β-defensins, lipocalin, and S100 proteins. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360128 Mon, 01 Mar 2010 00:00:00 +0100 3360128 http://www.medworm.com/index.php?rid=3360127&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674910001405%2Fabstract%3Frss%3Dyes With regard to the December 2009 article “Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome” (J Allergy Clin Immunol 2009;124:1289-1302), the name of co-author Necil Kutukculer was misspelled in the list of authors. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360127 Mon, 01 Mar 2010 00:00:00 +0100 3360127 http://www.medworm.com/index.php?rid=3360126&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909018120%2Fabstract%3Frss%3Dyes Conclusions: This study is the first to demonstrate a novel allergen-specific therapy for allergy through DC-mediated immune modulation after gene silencing of CD40. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360126 Mon, 01 Mar 2010 00:00:00 +0100 3360126 http://www.medworm.com/index.php?rid=3360121&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909018119%2Fabstract%3Frss%3Dyes Conclusions: Greater IgE epitope diversity and higher affinity, as determined by using the peptide microarray, were associated with clinical phenotypes and severity of milk allergy. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360121 Mon, 01 Mar 2010 00:00:00 +0100 3360121 http://www.medworm.com/index.php?rid=3360119&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674910000072%2Fabstract%3Frss%3Dyes Conclusions: In this referral population approximately 50% of children with soy allergy outgrew their allergy by age 7 years. Absolute soy IgE levels were useful predictors of outgrowing soy allergy. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360119 Mon, 01 Mar 2010 00:00:00 +0100 3360119 http://www.medworm.com/index.php?rid=3360118&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909027341%2Fabstract%3Frss%3Dyes Conclusion: Increasing the dosage of levocetirizine and desloratadine up to 4-fold improves chronic urticaria symptoms without compromising safety in approximately three quarters of patients with difficult-to-treat chronic urticaria. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360118 Mon, 01 Mar 2010 00:00:00 +0100 3360118 http://www.medworm.com/index.php?rid=3360117&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909018193%2Fabstract%3Frss%3Dyes Conclusions: Several S100 proteins are in the epidermal differentiation complex of genes and have been demonstrated to play a role in maintenance of barrier function and formation of an antimicrobial shield. We demonstrate significantly decreased levels of expression of S100 proteins in the epithelium of patients with CRS, which might lead to diminished innate immune responses and barrier function. Increased levels of calprotectin in nasal polyp tissue might reflect neutrophil recruitment and a compensatory mechanism. Future studies will be important to determine whether reduced levels of S100 proteins lead to decreased antimicrobial responses in the upper airways and sinuses and whether this reduction plays a causative role in CRS pathogenesis and susceptibility to infectious disease. (So... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360117 Mon, 01 Mar 2010 00:00:00 +0100 3360117 http://www.medworm.com/index.php?rid=3360115&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909018156%2Fabstract%3Frss%3Dyes Conclusion: The risk for development of persistent wheeze in children can be quantified by means of integration of measures related to early sensitization and early infections. Follow-up studies along similar lines in larger unselected populations to refine this approach are warranted. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360115 Mon, 01 Mar 2010 00:00:00 +0100 3360115 http://www.medworm.com/index.php?rid=3360114&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674910001399%2Fabstract%3Frss%3Dyes The current health reform debate has laid bare the challenge with determining appropriate care in an environment of uncertain medical effectiveness and rising health care costs. Comparative and cost-effectiveness studies are policy tools that permit decision-makers, theoretically, to allocate limited resources toward the greatest health benefit. Without these tools, opportunity to improve health may be missed. For example, would investing in early childhood screening miss an opportunity for greater health benefits from an investment in improving adherence to treatments for asthma? (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360114 Mon, 01 Mar 2010 00:00:00 +0100 3360114 http://www.medworm.com/index.php?rid=3360113&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909028759%2Fabstract%3Frss%3Dyes Conclusion: Population-based asthma screening is not cost-effective at $50,000 per QALY and has only a 20% chance of being cost-effective at $100,000 per QALY. The most efficient approach is to screen for previously diagnosed but poorly controlled asthma. Linking screening with better treatment, and long-term adherence strategies might yield future cost-effective approaches. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360113 Mon, 01 Mar 2010 00:00:00 +0100 3360113 http://www.medworm.com/index.php?rid=3360112&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909027316%2Fabstract%3Frss%3Dyes Conclusion: Blacks with asthma are more likely to have multiple asthma hospitalizations in Mississippi. Higher odds of multiple asthma discharges for Delta residents were not explained by race, sex, age, or income, indicating that other contributing factors (eg, environmental, social, and access to care factors) need further investigation. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360112 Mon, 01 Mar 2010 00:00:00 +0100 3360112 http://www.medworm.com/index.php?rid=3360108&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674910001132%2Fabstract%3Frss%3Dyes In the mid-1980s, the respiratory community responded with surprising speed and consensus to identify the treatment factors most responsible for the phenomenon of rising asthma mortality. Overreliance on bronchodilator therapy had led to a crisis-oriented approach to care whereby symptoms were responded to rather than prevented. Guidelines subsequently emphasized the early use of inhaled corticosteroids to quench underlying airways inflammation, thereby preventing symptoms and clinical instability. This widely adopted approach has been successful in reducing asthma mortality, and more recent guidelines have taught physicians to titrate their maintenance therapy to suppress all or nearly all day-to-day symptoms of asthma not only because this is intrinsically worthwhile to patients seeking ... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360108 Mon, 01 Mar 2010 00:00:00 +0100 3360108 http://www.medworm.com/index.php?rid=3360105&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674910002058%2Fabstract%3Frss%3Dyes Conclusion: Adiposity is associated with poorer asthma control in female subjects. Adiponectin is associated with improved asthma control in male subjects. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360105 Mon, 01 Mar 2010 00:00:00 +0100 3360105 http://www.medworm.com/index.php?rid=3360104&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674910001752%2Fabstract%3Frss%3Dyes Sensitization to inhalants in preschoolers is recognized as a significant risk factor for subsequent development of persistent asthma, but Holt et al (p 653) have now demonstrated that potentially useful prognostic information on their atopy and asthma risk can be gleaned from IgE measurements of less than the conventional 0.35 kU/L IgE threshold. Notably, 86.1% of high-risk 2-year-olds who attained house dust mite–specific IgE titers of 0.2 kU/L or greater progressed to beyond the sensitization threshold by age 5 years. Moreover, their risk for subsequent asthma increased progressively from 11.3% to 59.2%, with specific IgE titers attained (see the left column of the Table), and, consistent with earlier studies, asthma risk appears markedly amplified if they also experienced early sever... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360104 Mon, 01 Mar 2010 00:00:00 +0100 3360104 http://www.medworm.com/index.php?rid=3360103&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS009167491000117X%2Fabstract%3Frss%3Dyes Our work group report details the importance of pest allergen exposure in inner-city asthma. We will focus specifically on mouse and cockroach exposure. We will discuss how exposure to these pests is common in the inner city and what conditions exist in urban areas that might lead to increased exposure. We will discuss how exposure is associated with allergen sensitization and asthma morbidity. Finally, we will discuss different methods of intervention and the effectiveness of these tactics. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360103 Mon, 01 Mar 2010 00:00:00 +0100 3360103 http://www.medworm.com/index.php?rid=3360101&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674910001168%2Fabstract%3Frss%3Dyes In 2009, reports on basic and clinical immunology had an increased focus on human disease mechanisms and management. The molecular pathogenesis of familial angioedema associated with estrogen was further explored to find possible factors affecting severity, including polymorphisms in enzymes and receptors related to bradykinin pathways. A placebo-controlled clinical trial of C1 esterase inhibitor concentrate in patients with hereditary angioedema demonstrated the safety of its use and its efficacy to reduce the duration of angioedema attacks. The interaction of innate immunity and adaptive responses was further examined in several reports, establishing the significant role of Toll-like receptor stimulation for the development of optimal specific antibody responses. The 2009 update of the... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360101 Mon, 01 Mar 2010 00:00:00 +0100 3360101 http://www.medworm.com/index.php?rid=3360098&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674910001703%2Fabstract%3Frss%3Dyes Childhood asthma is not distributed evenly throughout the population, and children who grow up in crowded urban neighborhoods have higher rates of asthma and experience greater morbidity because of asthma. There are several environmental and lifestyle factors associated with urban living that are suspected to promote the development of asthma, particularly in the first few years of life. Collectively, this information suggests the hypothesis that exposure in early life to adverse environmental and lifestyle factors associated with disadvantaged urban environments modifies immune development to increase the risk for allergic diseases and asthma. The Urban Environment and Childhood Asthma (URECA) birth cohort study was initiated in 2004 to test this hypothesis. The study population was recru... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360098 Mon, 01 Mar 2010 00:00:00 +0100 3360098 http://www.medworm.com/index.php?rid=3360097&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674910001739%2Fabstract%3Frss%3Dyes Since 1991, the National Institute of Allergy and Infectious Diseases (NIAID) has funded four consecutive research initiatives to investigate the problem of high asthma prevalence, morbidity and mortality in poor urban communities. The multi-site studies conducted under these initiatives have identified key risk factors for asthma morbidity and novel interventions to improve asthma control. NIAID focuses its asthma and allergy programs on understanding the interaction of the immune system with allergens and infectious agents and identifying genetic and epigenetic elements that influence the immune system. A key goal in this field is to define mechanisms of immune system deviation and immune tolerance and apply this knowledge to generate improvements in asthma care and allergen immunotherap... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360097 Mon, 01 Mar 2010 00:00:00 +0100 3360097 http://www.medworm.com/index.php?rid=3360096&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674910002071%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360096 Mon, 01 Mar 2010 00:00:00 +0100 3360096 http://www.medworm.com/index.php?rid=3360095&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674910001697%2Fabstract%3Frss%3Dyes Asthma in inner-city children is prevalent, has increased severity, and for many patients poses difficulty in achieving control. Although some of the limitations to asthma control in inner-city children include socioeconomic burdens, other factors, such as environmental allergens, pollutants, infections, and stress, contribute significantly to the disease burden found in these children. As a consequence of these unmet needs for asthma control in inner-city children, the National Institute of Allergy and Infectious Diseases established research networks with an ultimate goal of improving care for this at-risk population. The Inner-City Asthma Network Program began in 1991 and has, over the ensuing years, funded 3 distinct networks that have a common goal: to improve care for the child wit... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360095 Mon, 01 Mar 2010 00:00:00 +0100 3360095 http://www.medworm.com/index.php?rid=3360094&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674910001430%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360094 Mon, 01 Mar 2010 00:00:00 +0100 3360094 http://www.medworm.com/index.php?rid=3360093&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674910001193%2Fabstract%3Frss%3Dyes For children living in inner cities, asthma tends to be more frequent and severe. To characterize, understand, and treat children with asthma living in the inner city more effectively, the National Institute of Allergy and Infectious Diseases established an Inner-City Asthma Program in 1991. In addition, the revised National Asthma Education and Prevention Program Expert Panel 3 report was introduced with new concepts for asthma management that are now centered on asthma control. The purpose of this review is to highlight features of the National Institute of Allergy and Infectious Diseases Inner-City Asthma Consortium Asthma Control Evaluation study that enhance our knowledge regarding the application of the asthma guidelines and to provide a summary of lessons learned from that important... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360093 Mon, 01 Mar 2010 00:00:00 +0100 3360093 http://www.medworm.com/index.php?rid=3360092&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909028796%2Fabstract%3Frss%3Dyes A lot of research is being published characterizing asthma pathogenesis in terms of genetic, morphogenetic, epigenetic, and/or in utero influences. In this month's News Beyond Our Pages we present overviews of a number of interesting reports published in the recent literature on different mechanisms that contribute to in utero and perinatal lung function. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360092 Mon, 01 Mar 2010 00:00:00 +0100 3360092 http://www.medworm.com/index.php?rid=3360091&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674910002988%2Fabstract%3Frss%3Dyes ▪ 2010 Virtual Annual Meeting: (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360091 Mon, 01 Mar 2010 00:00:00 +0100 3360091 http://www.medworm.com/index.php?rid=3360090&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674910002976%2Fabstract%3Frss%3Dyes During the 2010 Annual Meeting in New Orleans, Mark Ballow, MD, FAAAAI, began his year as AAAAI President. This month, Ballow took time to answer a few questions. You have a special interest in immunodeficiencies. What are the most exciting scientific inroads in this area? It has been almost 40 years since I finished my clinical immunology fellowship under Robert A. Good at the University of Minnesota. Dr. Good performed the first bone marrow transplant in a patient with Severe Combined Immunodeficiency Disease. Fortunately, the donor was an HLA, MLC matched sibling. The patient is now alive and well and has a family of his own. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360090 Mon, 01 Mar 2010 00:00:00 +0100 3360090 http://www.medworm.com/index.php?rid=3360089&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674910002964%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360089 Mon, 01 Mar 2010 00:00:00 +0100 3360089 http://www.medworm.com/index.php?rid=3360088&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674910002940%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360088 Mon, 01 Mar 2010 00:00:00 +0100 3360088 http://www.medworm.com/index.php?rid=3360087&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674910002939%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360087 Mon, 01 Mar 2010 00:00:00 +0100 3360087 http://www.medworm.com/index.php?rid=3360086&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674910002927%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360086 Mon, 01 Mar 2010 00:00:00 +0100 3360086 http://www.medworm.com/index.php?rid=3360085&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674910002915%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360085 Mon, 01 Mar 2010 00:00:00 +0100 3360085 http://www.medworm.com/index.php?rid=3360142&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909018089%2Fabstract%3Frss%3Dyes To the Editor: We thank the authors for their comment on our study of Trichuris suis ova for the treatment of allergic rhinitis. The study was a randomized, double-blind, placebo-controlled clinical trial in which 96 subjects with grass pollen allergy received 8 treatments with 2,500 T suis ova or placebo. We observed no beneficial clinical effect on their pollen allergy, as well as no subclinical effect after 6 months (168 days). (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360142 Fri, 12 Feb 2010 00:00:00 +0100 3360142 http://www.medworm.com/index.php?rid=3360141&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909018090%2Fabstract%3Frss%3Dyes To the Editor: We were recently intrigued by the findings of a clinical trial using Trichuris suis ova as treatment for patients with allergic rhinitis. T suis ova are prime candidates for the clinical therapy of allergic and inflammatory diseases in the growing field of helminth immunomodulation, having previously been successfully applied in patients with Crohn disease. A plethora of epidemiologic and laboratory studies have brought the beneficial effects of helminth infections into focus in recent years. Loss of helminth infections (including Trichuris trichiura) through deworming of children living in endemic regions resulted in a consequent increase in skin reactivity to house dust mite allergens. Similarly, we were able to show that helminth infection abrogated clinical symptoms an... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360141 Fri, 12 Feb 2010 00:00:00 +0100 3360141 http://www.medworm.com/index.php?rid=3360140&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909027882%2Fabstract%3Frss%3Dyes To the Editor: We compliment Bager et al for performing the first randomized, double-blind controlled trial of Trichuris suis ova in the treatment of allergic rhinitis. They concluded that the agent had no therapeutic effect on grass pollen–induced disease. Our studies demonstrated that T suis exposure reduced disease activity in patients with immune-mediated ulcerative colitis and Crohn disease. Mechanistic studies in animals demonstrated that helminth exposure reduced hyperactive airway disease through induction of regulatory T cells. In the study by Bager et al, T suis ova treatment produced definite biologic effects, including increased eosinophil counts and T suis–specific IgE, IgG4, and IgA levels. These observations established that T suis had a significant effect on the human... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360140 Fri, 12 Feb 2010 00:00:00 +0100 3360140 http://www.medworm.com/index.php?rid=3360132&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909027353%2Fabstract%3Frss%3Dyes To the Editor: Allergic asthma is a chronic inflammatory disease of the lungs characterized by TH2-type immune bias. Apart from the infiltrating immune cells, the epithelium is increasingly considered as an active immune player producing numerous inflammatory mediators. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360132 Fri, 12 Feb 2010 00:00:00 +0100 3360132 http://www.medworm.com/index.php?rid=3360125&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909017965%2Fabstract%3Frss%3Dyes Conclusion: Dendritic cells differentiated in the presence of IL-10 and pulsed with allergen gave rise to a population of tolerogenic DCs that induced allergen-specific Tr1 cells. This finding represents an important step forward to the prospective clinical application of tolerogenic DCs to modulate allergen-specific T-cell responses. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360125 Fri, 12 Feb 2010 00:00:00 +0100 3360125 http://www.medworm.com/index.php?rid=3360116&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909027298%2Fabstract%3Frss%3Dyes Conclusion: Standardized glycerinated short ragweed pollen extract administered sublingually at maintenance doses of 4.8 to 48 μg Amb a 1/d was safe and can induce favorable clinical and immunologic changes in ragweed-sensitive subjects. However, additional trials are needed to establish efficacy. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360116 Fri, 12 Feb 2010 00:00:00 +0100 3360116 http://www.medworm.com/index.php?rid=3360111&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909017175%2Fabstract%3Frss%3Dyes Conclusion: We conclude that L-arginine administration may improve disordered nitric oxide metabolism associated with allergic airway inflammation, and alleviates some features of asthma. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360111 Fri, 12 Feb 2010 00:00:00 +0100 3360111 http://www.medworm.com/index.php?rid=3360107&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909017709%2Fabstract%3Frss%3Dyes Conclusions: Current control predicts future risk of instability and exacerbations. Budesonide/formoterol maintenance and reliever therapy reduces exacerbations versus comparators and achieves at least similar control. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360107 Fri, 12 Feb 2010 00:00:00 +0100 3360107 http://www.medworm.com/index.php?rid=3360099&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909017199%2Fabstract%3Frss%3Dyes Psychosocial stress alters susceptibility to infectious and systemic illnesses and may enhance airway inflammation in asthma by modulating immune cell function through neural and hormonal pathways. Stress activates the hypothalamic-pituitary-adrenal axis. Release of endogenous glucocorticoids, as a consequence, may play a prominent role in altering the airway immune homeostasis. Despite substantial corticosteroid and catecholamine plasma levels, chronic psychosocial stress evokes asthma exacerbations.Animal studies suggest that social stress induces corticosteroid insensitivity that in part may be a result of impaired glucocorticoid receptor expression and/or function. Such mechanisms likely promote and amplify airway inflammation in response to infections, allergen, or irritant exposure. ... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360099 Fri, 12 Feb 2010 00:00:00 +0100 3360099 http://www.medworm.com/index.php?rid=3360139&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS009167490901728X%2Fabstract%3Frss%3Dyes To the Editor: Dr Brenna raises several important issues in his commentary. In epidemiologic studies, selection bias and lack of generalizability are not uncommon concerns. Study findings can be influenced by self-selection (ie, the healthy worker effect), especially in cross-sectional occupational studies. Studies of farming populations, however, have provided a unique opportunity to study the role of environmental factors in the development of atopic disorders. In the study by Mandhane et al, the longitudinal data were derived from a large, unselected, population-based cohort, which is one of the major strengths of the work. Indeed, the authors found no signs of selection bias in their study. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360139 Mon, 08 Feb 2010 00:00:00 +0100 3360139 http://www.medworm.com/index.php?rid=3360138&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909017278%2Fabstract%3Frss%3Dyes To the Editor: We thank Dr Brenna for his comments on our article. We do not know what aspect of cat and dog ownership might reduce the risk of allergy. As we acknowledge in the article, the apparent protective effect could be a result of exposure to allergens, endotoxins, or perhaps some other exposure associated with pet ownership, as Dr Brenna suggests. However, we do not think that a “healthy worker” effect can account for our findings because neither a family history of allergies nor a personal history of atopy influenced pet ownership. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360138 Mon, 08 Feb 2010 00:00:00 +0100 3360138 http://www.medworm.com/index.php?rid=3360137&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909017291%2Fabstract%3Frss%3Dyes To the Editor: Because I am very keen on cats and dogs, I read with interest both the article by Mandhane et al and the related editorial. The first article provides evidence that living with cats and dogs is associated with a lower risk of atopy during childhood and young adulthood. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360137 Mon, 08 Feb 2010 00:00:00 +0100 3360137 http://www.medworm.com/index.php?rid=3360131&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS009167490901793X%2Fabstract%3Frss%3Dyes To the Editor: It has been proposed in several observational studies that paracetamol might be a risk factor for asthma (see the recent review by Farquhar et al in the Journal of Allergy and Clinical Immunology). Confounding factors are difficult to control in observational studies because the allocation to treatment groups does not take place at random. A large sample size will increase the statistical precision, however, and allow adjustment for multiple confounders, but it does not eliminate the problems entailed in observational surveys. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360131 Mon, 08 Feb 2010 00:00:00 +0100 3360131 http://www.medworm.com/index.php?rid=3360102&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909016388%2Fabstract%3Frss%3Dyes Subcutaneous allergen immunotherapy (SCIT) is an effective treatment for allergic rhinitis, asthma and venom hypersensitivity and has the potential of producing serious life-threatening anaphylaxis. Adverse reactions are generally classified into 2 categories: local reactions, which can manifest as redness, pruritus, and swelling at the injection site, and systemic reactions (SRs). SRs can range in severity from mild rhinitis to fatal cardiopulmonary arrest. Early administration of epinephrine, which is the treatment of choice to treat anaphylaxis, may prevent the progression of an SR to a more serious life-threatening problem. Although there is little debate about using epinephrine to treat a SCIT SR, there is a lack of consensus about when it should be first used. A uniform classificatio... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360102 Mon, 08 Feb 2010 00:00:00 +0100 3360102 http://www.medworm.com/index.php?rid=3360100&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674910000096%2Fabstract%3Frss%3Dyes The year 2009 led to a number of significant advances in environmental and occupational allergic diseases. The role of exposure to environmental pollutants, respiratory viruses, and allergen exposure showed significant advances. New allergens were identified. Occupational asthma and the relationship of complementary and alternative medicine to allergic diseases were extensively reviewed. New approaches to immunotherapy, novel vaccine techniques, and methods to reduce risks for severe allergic disease were addressed. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360100 Mon, 08 Feb 2010 00:00:00 +0100 3360100 http://www.medworm.com/index.php?rid=3360136&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909016418%2Fabstract%3Frss%3Dyes To the Editor: In a recent article, Hur et al reported that by using a proteomic approach, ferritin expression was downregulated whereas transferrin expression was upregulated in bronchoalveolar lavage fluid in subjects with methylene diphenyl diisocyanate–induced occupational asthma (MDI-OA) or eosinophilic bronchitis compared with exposed asymptomatic control workers (AECs) to methylene diphenyl diisocyanate (MDI). The authors also measured these compounds by ELISA using sera from the MDI-OA/eosinophilic bronchitis and AEC groups. The results showed that serum ferritin and transferrin can be serologic markers in diagnosing MDI-OA. To identify subjects with MDI-OA, the optimal serum cut-off levels were 69.84 ng/mL for ferritin and 2.48 mg/mL for transferrin. When these 2 parameters wer... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360136 Thu, 04 Feb 2010 00:00:00 +0100 3360136 http://www.medworm.com/index.php?rid=3360135&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS009167490901639X%2Fabstract%3Frss%3Dyes To the Editor: Adults with asthma are at substantially higher risk for panic disorder (PD) than individuals without asthma. There is evidence that asthma and PD may interact with each other and produce greater morbidity for each disease. Respiratory-related symptoms, such as dyspnea, chest tightness, and sensations of smothering are common in both disorders. The overlap in symptoms may lead an individual to mistake a panic attack as an asthma attack. This confusion may trigger a maladaptive cycle of using short-acting β2-agonists to treat respiratory anxiety symptoms, mistaken as asthma, and thus further increasing feared bodily sensations and panic. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360135 Thu, 04 Feb 2010 00:00:00 +0100 3360135 http://www.medworm.com/index.php?rid=3360134&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909016315%2Fabstract%3Frss%3Dyes To the Editor: The Fc receptor family plays a key role in adaptive immunity through the binding of immunoglobulin antibodies that recognize an immune insult and elicit an inflammatory response leading to its clearance. Dysregulation of this receptor family may have untoward consequences that result in autoimmune and allergic diseases. Many of these diseases seem to involve the nervous system and are exacerbated by stress or other neurologic challenges. Recently, the presence of Fc receptors was uncovered on dorsal root ganglion neurons and suggested an IgG and possibly IgE-mediated activation of neurons. We set out to explore more extensively which Fc receptors might be expressed in neurons, and whether they were functional and able to transmit signals to interconnected neurites in vitro ... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360134 Thu, 04 Feb 2010 00:00:00 +0100 3360134 http://www.medworm.com/index.php?rid=3360123&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909016297%2Fabstract%3Frss%3Dyes Conclusion: We report for the first time how epitopes of allergens are generated and selected for presentation to T lymphocytes. The limited susceptibility of Bet v 1 to endolysosomal processing might contribute to its high allergenic potential. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360123 Thu, 04 Feb 2010 00:00:00 +0100 3360123 http://www.medworm.com/index.php?rid=3360122&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909015668%2Fabstract%3Frss%3Dyes Conclusion: CD94/NKG2C might be involved in triggering cytotoxic lymphocytes in patients with SJS and TEN. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360122 Thu, 04 Feb 2010 00:00:00 +0100 3360122 http://www.medworm.com/index.php?rid=3360109&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909016303%2Fabstract%3Frss%3Dyes Conclusion: The persistent functional abnormality of small conductive airways in patients with stable asthma is largely independent of inflammation as measured by exhaled NO. In the alveolar compartment, a functional correlate of alveolar NO was found in a subgroup of patients with stable asthma on moderate-to-high maintenance doses of inhaled steroids. These patients in particular could benefit from novel therapies specifically aimed at improving airway functionality at the level of the acinar entrance and beyond. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360109 Thu, 04 Feb 2010 00:00:00 +0100 3360109 http://www.medworm.com/index.php?rid=3360106&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS009167490901584X%2Fabstract%3Frss%3Dyes Conclusion: Outdoor fungal exposure is primarily associated with increased asthma symptoms and increased risk of exacerbations in this population. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360106 Thu, 04 Feb 2010 00:00:00 +0100 3360106 http://www.medworm.com/index.php?rid=3360110&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909015450%2Fabstract%3Frss%3Dyes Conclusion: Early-life respiratory chlamydial infections modulate immune responses, alter lung function and structure, and enhance the severity of allergic airways disease in later life. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360110 Mon, 01 Feb 2010 00:00:00 +0100 3360110 http://www.medworm.com/index.php?rid=3260153&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS009167490902836X%2Fabstract%3Frss%3Dyes When oral corticosteroids are indicated for patients with asthma, the response to treatment should be anticipated and weighed against potential risks or side effects. This discussion is focused on the immune effects of systemic corticosteroids. In some patients with persistent severe asthma, it might be impossible to achieve effective control of asthma without oral corticosteroids. As outpatients, patients can begin to respond within 1 to 2 hours of initiation of prednisone as part of an action plan, whereas other patients might require 6 to more than 48 hours or longer to begin to improve. The half-life of prednisone is between 1 and 3 hours, and anti-inflammatory effects from oral or intravenous corticosteroids occur promptly. CD4+ T-lymphocyte and peripheral blood eosinophil numbers dec... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260153 Mon, 01 Feb 2010 00:00:00 +0100 3260153 http://www.medworm.com/index.php?rid=3260152&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909017400%2Fabstract%3Frss%3Dyes To the Editor: Regarding our article about meta-analyses (MAs) on sublingual immunotherapy, we have read with much interest the letters by Calamita and Compalati et al. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260152 Mon, 01 Feb 2010 00:00:00 +0100 3260152 http://www.medworm.com/index.php?rid=3260151&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909017394%2Fabstract%3Frss%3Dyes To the Editor: We have read with great interest the article by Nieto et al, which claims insufficient evidence for the use of SLIT on the basis of discrepancies and inconsistencies found in the published meta-analyses (MAs). In this regard, we would like to discuss some of the points specifically raised by the authors. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260151 Mon, 01 Feb 2010 00:00:00 +0100 3260151 http://www.medworm.com/index.php?rid=3260150&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909017382%2Fabstract%3Frss%3Dyes To the Editor: I would like to clarify some points raised by Nieto et al regarding the systematic review by Calamita et al about the efficacy of sublingual immunotherapy in asthma. In accordance with the Cochrane handbook, for analysis of continuous outcome through intention-to-treat methods, it is required that means and SDs are available for all participants; however, this unfortunately did not happen. Although attempts were made to contact the authors to get the necessary information, in some cases no responses were obtained. In these cases, we decided to extract the SDs from P values through indirect calculation following guidance from the Cochrane handbook. Because of this, in our meta-analyses, the continuous outcome was performed in relation to the patients who finished the treatme... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260150 Mon, 01 Feb 2010 00:00:00 +0100 3260150 http://www.medworm.com/index.php?rid=3260146&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909017692%2Fabstract%3Frss%3Dyes To the Editor: Immediate allergic reactions to penicillins usually appear within 1 hour after drug intake and are mediated by specific IgE antibodies. Amoxicillin is the penicillin most frequently involved in sensitization, with the side chain playing a relevant role. Amoxicillin is commercialized alone or combined to clavulanic acid (CLV). Although initial studies showed that CLV had a low immunogenic capacity, allergic reactions to this compound may exist. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260146 Mon, 01 Feb 2010 00:00:00 +0100 3260146 http://www.medworm.com/index.php?rid=3260145&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909017187%2Fabstract%3Frss%3Dyes To the Editor: Schnitzler syndrome is a rare, enigmatic disorder characterized by chronic urticarial rashes and a monoclonal IgM gammopathy, variably combined with intermittent fever, arthralgia or arthritis, lymphadenopathy, hepatomegaly and/or splenomegaly, leukocytosis, and an elevated erythrocyte sedimentation rate. Patients have an excess risk for Waldenström macroglobulinemia and amyloidosis. Both increased secretion of the proinflammatory cytokine IL-1 from PBMCs and efficacy of anakinra (soluble IL-1 receptor antagonist) treatment suggest an important role of IL-1 in the disease process. However, the cause of increased IL-1 secretion has remained obscure. Here, we report on a gain-of-function mutation (V198M) of a gene (nucleotide-binding domain protein and leucine-rich repeat c... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260145 Mon, 01 Feb 2010 00:00:00 +0100 3260145 http://www.medworm.com/index.php?rid=3260144&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909016431%2Fabstract%3Frss%3Dyes To the Editor: Atopic diseases such as atopic dermatitis (AD) and allergic rhinitis are some of the most common diseases in developed societies, and the number of patients with these diseases is increasing. These diseases are caused by interactions between genetic and environmental factors; some patients develop various atopic diseases concurrently, whereas others show a gradual progression from one manifestation of allergy to the next (atopic march), thereby indicating common genetic/environmental features among atopic diseases. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260144 Mon, 01 Feb 2010 00:00:00 +0100 3260144 http://www.medworm.com/index.php?rid=3260143&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909016352%2Fabstract%3Frss%3Dyes To the Editor: Vernal keratoconjunctivitis (VKC) is a bilateral ocular disease characterized by chronic inflammation of the whole conjunctiva with variable corneal involvement. Conjunctival “cobblestone papillae” are a characteristic of the disease; the cornea can develop punctate keratitis, erosions, shield ulcers, plaques, and neovascularization. VKC typically appears before the age of 10 years and tends to improve or remit in adulthood. The term vernal is largely accepted for historical reasons because VKC sometimes displays spring or autumn exacerbations that are followed by periods of remission. Nonetheless, the term is not completely appropriate, because many patients with VKC have exacerbations during winter or develop a perennial form of the disease. VKC might occur in people ... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260143 Mon, 01 Feb 2010 00:00:00 +0100 3260143 http://www.medworm.com/index.php?rid=3260142&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909016078%2Fabstract%3Frss%3Dyes To the Editor: Severe ocular allergic diseases such as vernal and atopic keratoconjunctivitis involve not only conjunctival allergic inflammation but also various corneal disorders. Corneal complications such as persistent corneal erosion can threaten vision and are often resistant to therapy, thus remaining a challenge in the treatment of ocular allergy. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260142 Mon, 01 Feb 2010 00:00:00 +0100 3260142 http://www.medworm.com/index.php?rid=3260141&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909017473%2Fabstract%3Frss%3Dyes We examined the natural history of AE in children enrolled in the Childhood Origin of ASThma (COAST) study, a high-risk birth cohort composed of children with parental histories of asthma and/or allergies, to define early risk factors for the persistent expression of disease. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260141 Mon, 01 Feb 2010 00:00:00 +0100 3260141 http://www.medworm.com/index.php?rid=3260140&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909017217%2Fabstract%3Frss%3Dyes To the Editor: Solar urticaria is an uncommon but well described condition. Previously classified into 6 types (I-VI) based on the action spectrum, solar urticaria is now divided into 2 types: type I and type II. Type I defines patients who have precursors located in the serum, plasma, or cutaneous tissue fluid that become photoallergens once activated by the appropriate wavelength and bind to IgE receptors, resulting in mast cell degranulation. Type II is also IgE-mediated, but precursors are found in both healthy patients and patients with solar urticaria. It is hypothesized that only patients with solar urticaria have an abnormal circulating IgE autoantibody that recognizes these irradiated precursors. When treating solar urticaria, success is defined as either complete resolution of s... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260140 Mon, 01 Feb 2010 00:00:00 +0100 3260140 http://www.medworm.com/index.php?rid=3260139&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909017680%2Fabstract%3Frss%3Dyes Conclusion: Asthma exacerbation was accompanied by increased expression of CD203c on basophils that decreased significantly during remission. Basophil expression levels of CD203c might therefore be used to monitor asthma in patients. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260139 Mon, 01 Feb 2010 00:00:00 +0100 3260139 http://www.medworm.com/index.php?rid=3260138&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909017503%2Fabstract%3Frss%3Dyes Conclusion: These studies identify previously unrecognized sites of localization, the membranes of intracellular eosinophil granule organelles, and function for cysLT-responsive receptors that mediate cysteinyl leukotriene-stimulated secretion from within eosinophil granules, including those present extracellularly. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260138 Mon, 01 Feb 2010 00:00:00 +0100 3260138 http://www.medworm.com/index.php?rid=3260137&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS009167490901553X%2Fabstract%3Frss%3Dyes Conclusions: Parenteral antigen–induced murine systemic anaphylaxis is mediated by both IgG- and IgE-dependent pathways, and both can occur independently of IL-9/IL-9R signaling. In contrast, oral antigen–induced intestinal and systemic anaphylaxis is strictly IgE mediated and requires IL-9/IL-9R signaling. These studies indicate differential involvement of the IL-9/IL-9R pathway in systemic and oral antigen–induced anaphylaxis. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260137 Mon, 01 Feb 2010 00:00:00 +0100 3260137 http://www.medworm.com/index.php?rid=3260134&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909017710%2Fabstract%3Frss%3Dyes Conclusion: Despite the high proportion of functional revertant T cells, the patient still has severe infections and autoimmune disorders, suggesting that re-expression of WASP in T cells is not sufficient to normalize immune functions fully in patients with WAS. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260134 Mon, 01 Feb 2010 00:00:00 +0100 3260134 http://www.medworm.com/index.php?rid=3260132&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909016376%2Fabstract%3Frss%3Dyes Background: The hyper-IgE syndrome (HIES) is a primary immunodeficiency characterized by infections of the lung and skin, elevated serum IgE, and involvement of the soft and bony tissues. Recently, HIES has been associated with heterozygous dominant-negative mutations in the signal transducer and activator of transcription 3 (STAT3) and severe reductions of TH17 cells.Objective: To determine whether there is a correlation between the genotype and the phenotype of patients with HIES and to establish diagnostic criteria to distinguish between STAT3 mutated and STAT3 wild-type patients.Methods: We collected clinical data, determined TH17 cell numbers, and sequenced STAT3 in 100 patients with a strong clinical suspicion of HIES and serum IgE >1000 IU/mL. We explored diagnostic criteria by usin... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260132 Mon, 01 Feb 2010 00:00:00 +0100 3260132 http://www.medworm.com/index.php?rid=3260131&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909016339%2Fabstract%3Frss%3Dyes Conclusion: The number of reported unintentional injections from epinephrine auto-injectors increased annually from 1994 to 2007. To prevent these unintentional injections, improved epinephrine auto-injector design is needed, along with increased vigilance in training the trainers and in training and coaching the users, as well as efforts to increase public awareness of the role of epinephrine auto-injectors in the first-aid treatment of anaphylaxis in the community. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260131 Mon, 01 Feb 2010 00:00:00 +0100 3260131 http://www.medworm.com/index.php?rid=3260130&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS009167490901567X%2Fabstract%3Frss%3Dyes Conclusions: Nitroso sulfonamide metabolites form potent antigenic determinants for T cells from hypersensitive patients. T-cell responses against drugs (metabolites) bound directly to MHC or MHC/peptide complexes can occur through cross-reactivity with the haptenic immunogen. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260130 Mon, 01 Feb 2010 00:00:00 +0100 3260130 http://www.medworm.com/index.php?rid=3260129&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909016327%2Fabstract%3Frss%3Dyes Conclusion: Infants with eczema are at increased risk for mental health problems at age 10 years. Even if cleared afterward, eczema at age 1 to 2 years may cause persistent emotional and behavioral difficulties. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260129 Mon, 01 Feb 2010 00:00:00 +0100 3260129 http://www.medworm.com/index.php?rid=3260128&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909017436%2Fabstract%3Frss%3Dyes Conclusion: p-STAT3 levels are decreased in CRSwNP despite increased levels of IL-6 and sIL-6R and are associated with the absence of an IL-17 response. This may be a response to elevated levels of sgp130, a known inhibitor of IL-6 signaling. These results indicate that IL-6 and its signaling pathway may be altered in CRSwNP. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260128 Mon, 01 Feb 2010 00:00:00 +0100 3260128 http://www.medworm.com/index.php?rid=3260127&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909017734%2Fabstract%3Frss%3Dyes Conclusion: No evidence of increased risk of asthma-related hospitalization, no asthma-related deaths, and a low incidence of all-cause death and asthma-related intubation were seen with formoterol-containing versus non-LABA treatment. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260127 Mon, 01 Feb 2010 00:00:00 +0100 3260127 http://www.medworm.com/index.php?rid=3260126&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909017412%2Fabstract%3Frss%3Dyes Conclusion: Use of omalizumab in patients whose asthma was symptomatic despite use of inhaled corticosteroids was associated with fewer systemic allergic reactions to specific immunotherapy and enabled more patients to achieve the target immunotherapy maintenance dose. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260126 Mon, 01 Feb 2010 00:00:00 +0100 3260126 http://www.medworm.com/index.php?rid=3260125&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909028838%2Fabstract%3Frss%3Dyes Despite significant advances in long-term preventative treatments that reduce the frequency of asthma exacerbations, acute asthma remains a common and important medical problem. In particular, some patients have an inadequate response to available first-line therapies for acute asthma, including inhaled short-acting β-agonists and anticholinergic agents and systemic corticosteroids. In this issue of the Journal of Allergy and Clinical Immunology, Camargo et al present a randomized controlled trial of intravenous montelukast, a cysteinyl leukotriene 1 (CysLT1) receptor antagonist, added to current standard care for the treatment of acute asthma. Based on the prespecified, primary end point of the time-weighted average change in FEV1 over 60 minutes after drug administration, the investigat... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260125 Mon, 01 Feb 2010 00:00:00 +0100 3260125 http://www.medworm.com/index.php?rid=3260124&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909017321%2Fabstract%3Frss%3Dyes Background: Current treatments for acute asthma provide inadequate benefit for some patients. Intravenous montelukast may complement existent therapies.Objective: To evaluate efficacy of intravenous montelukast as adjunctive therapy for acute asthma.Methods: A total of 583 adults with acute asthma were treated with standard care during a ≤60-minute screening period. Patients with FEV1 ≤50% predicted were randomly allocated to intravenous montelukast 7 mg (n = 291) or placebo (n = 292) in addition to standard care. This double-blind treatment period lasted until a decision for discharge, hospital admission, or discontinuation from the study. The primary efficacy endpoint was the time-weighted average change in FEV1 during 60 minutes after drug administration. Secondary endpoints include... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260124 Mon, 01 Feb 2010 00:00:00 +0100 3260124 http://www.medworm.com/index.php?rid=3260123&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS009167490901642X%2Fabstract%3Frss%3Dyes Background: Ambient fine particles (particular matter (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260123 Mon, 01 Feb 2010 00:00:00 +0100 3260123 http://www.medworm.com/index.php?rid=3260122&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909016030%2Fabstract%3Frss%3Dyes Conclusion: Remission of asthma in adolescence is infrequent and not affected by 4 years of anti-inflammatory controller therapy. Factors such as sensitization and exposure, low lung function, and airway greater hyperresponsiveness decrease the likelihood of remitting asthma. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260122 Mon, 01 Feb 2010 00:00:00 +0100 3260122 http://www.medworm.com/index.php?rid=3260121&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909018181%2Fabstract%3Frss%3Dyes β-Agonists and inhaled corticosteroids (ICSs) form the cornerstone of asthma therapy. β-Agonists stimulate the Gs alpha-subunit of the G protein–coupled β2-receptor on the airway smooth muscle cell surface, resulting in the stimulation of adenylyl cyclase, which produces cyclic AMP. The resultant airway smooth muscle relaxation and increase in airway caliber mediate the predominant clinical effect of β-agonists as used in asthma pharmacotherapy. However, β2-receptors are not only present on the surface of airway smooth muscles but also on other cells, such as mast cells and fibroblasts. In vitro stimulation of these receptors results in decreased production of inflammatory mediators in mast cells and decreased extracellular matrix protein release from fibroblasts. Furthermore, some ... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260121 Mon, 01 Feb 2010 00:00:00 +0100 3260121 http://www.medworm.com/index.php?rid=3260119&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909028279%2Fabstract%3Frss%3Dyes “La' ci darem la mano”—“There we'll be hand in hand”—sings Don Giovanni to Zerlina in Act 1 of the opera the Danish philosopher Søren Kierkegaard called “a work without blemish, of uninterrupted perfection.” As if taking cues from Mozart's masterpiece, the genetics and biology of asthma are finally beginning to intertwine hands. This issue of our journal proudly presents 3 cutting-edge articles that recapitulate the joys and sorrows of asthma genetics 2010: the exciting power of discovery the field has found in genome-wide association studies (GWASs), the complex challenges GWASs inevitably still involve, and the preeminent role of biology in deciphering what genetic findings reveal about asthma susceptibility. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260119 Mon, 01 Feb 2010 00:00:00 +0100 3260119 http://www.medworm.com/index.php?rid=3260117&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909017357%2Fabstract%3Frss%3Dyes Conclusion: This GWAS confirmed the important role of TH2 cytokine and antigen presentation genes in asthma at a genome-wide level and the importance of additional investigation of these 2 regions to delineate their structural complexity and biologic function in the development of asthma. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260117 Mon, 01 Feb 2010 00:00:00 +0100 3260117 http://www.medworm.com/index.php?rid=3260115&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909028784%2Fabstract%3Frss%3Dyes Concerns exist that the risk of serious asthma-related events might increase with regular use of long-acting β2-adrenergic agonists (LABAs). In the most stringent assessment of formoterol safety data to date, Nelson et al (p 390) assessed the risk of serious asthma-related events with formoterol-containing treatment in a large data set (n = 23,510) of asthmatic patients aged 4 years or older. Data were from all blind, parallel-arm, randomized, active- and/or placebo-controlled, AstraZeneca-sponsored asthma studies with formoterol, a total of 42 studies in 13,542 subjects receiving formoterol and 9,968 receiving non-LABA regimens. Results showed no evidence of an increased risk for asthma-related hospitalizations with formoterol-containing versus non-LABA treatment (relative risk, 0.73; se... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260115 Mon, 01 Feb 2010 00:00:00 +0100 3260115 http://www.medworm.com/index.php?rid=3260114&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909027870%2Fabstract%3Frss%3Dyes The year 2009 was marked by rapid progress in understanding cellular and chemical mechanisms in the pathogenesis of asthma and other allergic disorders. Studies published in the Journal of Allergy and Clinical Immunology described advances in our knowledge of signaling molecules and pathways, cytokines, and activation and tolerance in asthma and murine models of this disease; food allergy; anaphylaxis and immediate hypersensitivity; mast cells and their disorders; atopic dermatitis; allergic conjunctivitis; nasal polyposis; and hypereosinophilic syndromes. Additional studies provided novel information about the induction and regulation of allergic inflammation and the genetic determinants of asthma and responsiveness to asthma therapy. Critical features of these studies and their potential... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260114 Mon, 01 Feb 2010 00:00:00 +0100 3260114 http://www.medworm.com/index.php?rid=3260113&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909028309%2Fabstract%3Frss%3Dyes Patients with moderate asthma are symptomatic on an ongoing basis. They are usually treated initially with low-dose inhaled corticosteroids (ICSs) supplemented with a short-acting bronchodilator as a rescue medication. Most steroid-naive patients will achieve good control with this strategy. For patients in whom adherence, inhaler technique, environmental control, and comorbidities have been addressed but who still have uncontrolled symptoms, the addition of a long-acting β-adrenergic agonist should be considered. Some patients might require a higher dose of ICS. Leukotriene receptor antagonists might be considered as alternate initial therapy or as an add-on to maintenance therapy with an ICS. All patients should receive a structured education program emphasizing the need for ongoing mai... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260113 Mon, 01 Feb 2010 00:00:00 +0100 3260113 http://www.medworm.com/index.php?rid=3260112&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909017928%2Fabstract%3Frss%3Dyes Asthma is a complex inflammatory disorder characterized by intense allergic inflammation, smooth muscle contraction, bronchial hyperresponsiveness, hypertrophy and hyperplasia of smooth muscle, hypersecretion of bronchial mucus, activation of mast cells, eosinophils, lymphocytes, epithelial cells, macrophages, disruption of the bronchial epithelium, and production of free radicals such as expired nitric oxide (eNO) and 8-isoprostane. The presence of asthma implies multiple potential targets of therapy, risk of future exacerbations, impaired quality of life, and potential for accelerated loss of FEV1. Patients with persistent asthma have a high likelihood of the comorbidities allergic rhinitis, rhinosinusitis, and gastroesophageal reflux. Furthermore, responses to pharmacotherapy vary for �... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260112 Mon, 01 Feb 2010 00:00:00 +0100 3260112 http://www.medworm.com/index.php?rid=3260111&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909027900%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260111 Mon, 01 Feb 2010 00:00:00 +0100 3260111 http://www.medworm.com/index.php?rid=3260110&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909018065%2Fabstract%3Frss%3Dyes There is a large amount of interindividual variability in both therapeutic and adverse responses to asthma therapies. Genetic variability can account for 50% to 60% of this variability. Pharmacogenomics holds out the promise of allowing clinicians to prospectively choose therapies that have the greatest likelihood to be effective for individual patients and to avoid those that might have a high likelihood of producing adverse effects. In this article we review the principles of pharmacogenomic investigation. We explore the data developed from the early pharmacogenomic studies with the most common asthma therapies. Furthermore, we explore the potential use of pharmacogenomics, as well as caveats in interpreting such information. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260110 Mon, 01 Feb 2010 00:00:00 +0100 3260110 http://www.medworm.com/index.php?rid=3260109&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909017448%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260109 Mon, 01 Feb 2010 00:00:00 +0100 3260109 http://www.medworm.com/index.php?rid=3260107&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674910000643%2Fabstract%3Frss%3Dyes Rob C. Aalberse Juan Pablo Abonia (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260107 Mon, 01 Feb 2010 00:00:00 +0100 3260107 http://www.medworm.com/index.php?rid=3260106&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909028772%2Fabstract%3Frss%3Dyes Every day, allergists are receiving telephone calls from asthmatic patients concerning fears of severe influenza A infection, asthma exacerbations, and advice for vaccination. Limited data are available on disease characteristics and outcomes of subjects with 2009 pandemic influenza A (H1N1). Both in children (CMAJ 2009, doi:10.1503/cmaj.091724) and adults (The ANZIC Influenza Investigators, N Engl J Med 2009;361:1925-34, and Jain et al, N Engl J Med 2009;361:1935-44), asthma appears to be a small risk factor for severe disease, with no clear relation to severity of asthma and not any greater risk for other chronic conditions, such as obesity or diabetes. Racial minorities are overrepresented among patients with severe infection. Indigenous populations from Australia, Canada, New Zealand, ... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260106 Mon, 01 Feb 2010 00:00:00 +0100 3260106 http://www.medworm.com/index.php?rid=3260105&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674910000576%2Fabstract%3Frss%3Dyes ▪ 2009 Practice Management Workshop DVD: Were you unable to participate in the workshop but want to experience the audio and slides of the entire meeting? Order your 2009 AAAAI Practice Management Workshop DVD and earn up to 31.25 CME or 37.50 CE credits. For more information or to place an order, visit www.associationarchives.com or contact the AAAAI Practice Management Team at (414) 272-6071 between 8 am and 5 pm Central Time. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260105 Mon, 01 Feb 2010 00:00:00 +0100 3260105 http://www.medworm.com/index.php?rid=3260104&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674910000564%2Fabstract%3Frss%3Dyes Be sure your itinerary in New Orleans includes the Presidential Plenary Session at the 2010 Annual Meeting, scheduled for Saturday, February 27 from 8:15 to 9:45 am. With Gurjit K. Khurana Hershey, MD, PhD, FAAAAI, serving as moderator, President Paul A. Greenberger, MD, FAAAAI, will speak on the heterogeneity of responses to the treatment of asthma. His presentation will center on identifying phenotypic characteristics of good or poor responders to inhaled and oral corticosteroids, beta2 adrenergic agonists and leukotriene modifiers. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260104 Mon, 01 Feb 2010 00:00:00 +0100 3260104 http://www.medworm.com/index.php?rid=3260103&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674910000552%2Fabstract%3Frss%3Dyes Communications regarding original articles and editorial management should be addressed to Donald Y. M. Leung, MD, PhD, Editor in Chief, The Journal of Allergy and Clinical Immunology, National Jewish Medical and Research Center, 1400 Jackson St (J324), Denver, CO 80206; phone 303-398-1963; fax 303-270-2269. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260103 Mon, 01 Feb 2010 00:00:00 +0100 3260103 http://www.medworm.com/index.php?rid=3260102&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674910000539%2Fabstract%3Frss%3Dyes Editor in Chief DONALD Y. M. LEUNG, MD, PhD Denver, Colo Deputy Editor STANLEY J. SZEFLER, MD Denver, Colo (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260102 Mon, 01 Feb 2010 00:00:00 +0100 3260102 http://www.medworm.com/index.php?rid=3260101&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674910000527%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260101 Mon, 01 Feb 2010 00:00:00 +0100 3260101 http://www.medworm.com/index.php?rid=3260100&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674910000515%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260100 Mon, 01 Feb 2010 00:00:00 +0100 3260100 http://www.medworm.com/index.php?rid=3260099&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674910000497%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260099 Mon, 01 Feb 2010 00:00:00 +0100 3260099 http://www.medworm.com/index.php?rid=3260154&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909018144%2Fabstract%3Frss%3Dyes In the second half of the 19th century, medical researchers paid increasing attention to the so-called ductless (endocrine) glands. In 1848, German physiologist Arnold Berthold provided the first evidence that one of these glands could secrete a physiologically active substance directly into the bloodstream. A castrated rooster normally exhibited a shrinking of its comb, but Berthold showed that this shrinking did not occur if the excised testes were transplanted into the abdominal cavity. He suggested that the testes must be secreting some substance into the blood that affected the comb. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260154 Mon, 18 Jan 2010 00:00:00 +0100 3260154 http://www.medworm.com/index.php?rid=3260108&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909015620%2Fabstract%3Frss%3Dyes In the past, we viewed lack of response to asthma medications as a rare event. Based on recent studies, we now expect significant variation in treatment response for all asthma medications. However, little information is available about methods to predict favorable treatment response. Research conducted in the National Heart, Lung, and Blood Institute's Asthma Clinical Research Network and Childhood Asthma Research and Education Network verified this variability in response to several long-term control medications, specifically inhaled corticosteroids and leukotriene receptor antagonists, in adults and children with mild-to-moderate persistent asthma. The networks also identified potential methods to use patients' characteristics, such as age and allergic status, and biomarkers, such as br... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260108 Thu, 14 Jan 2010 00:00:00 +0100 3260108 http://www.medworm.com/index.php?rid=3360130&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909018077%2Fabstract%3Frss%3Dyes To the Editor: For the 2009 to 2010 influenza season, 34 manufacturers in 19 countries are manufacturing influenza vaccines. In the United States, there are 5 manufacturers producing 1 nasal and 5 injectable Food and Drug Administration (FDA)–approved seasonal influenza vaccines. These manufacturers are also producing 1 nasal and 4 injectable H1N1 (hemagglutinin 1, neuraminidase 1) monovalent vaccines. Because influenza vaccines are developed by inoculating embryonated chicken eggs with virus, the final product has always contained ovalbumin, which can pose a risk in children and adults with egg allergy. However, because manufacturers do not report final lot ovalbumin content, allergists are directed to start with skin prick and intradermal skin testing to the vaccine followed by either... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360130 Mon, 11 Jan 2010 00:00:00 +0100 3360130 http://www.medworm.com/index.php?rid=3360124&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909015474%2Fabstract%3Frss%3Dyes Conclusion: Bone marrow MCs from SM show 3 different maturation-related immunophenotypic profiles that are associated with both the genetic markers of the disease and its clinical behavior. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360124 Mon, 11 Jan 2010 00:00:00 +0100 3360124 http://www.medworm.com/index.php?rid=3360120&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909015449%2Fabstract%3Frss%3Dyes Conclusion: Use of single kiwifruit allergen ImmunoCAP increases the quantitative test performance and diagnostic sensitivity compared with the commercial extract. Bet v 1 homolog and profilin are important allergens in pollen-related kiwifruit allergy, whereas actinidin is important in monoallergy to kiwifruit, in which symptoms are often more severe. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3360120 Mon, 11 Jan 2010 00:00:00 +0100 3360120 http://www.medworm.com/index.php?rid=3260149&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909015437%2Fabstract%3Frss%3Dyes To the Editor: We appreciate the critical comments from Zhang et al on our study. The major criticism questions the sensitivity and accuracy of the measurements of TGF-β1 and forkhead box protein 3 (Foxp3) mRNA expression in our study, because these results are discordant with previous reports by their group. In response to this question, we have retested TGF-β1 and Foxp3 mRNA expression, using both the primers constructed for our previous study and new ones constructed from the sequences reported by their group in a new set of samples obtained from 10 patients with septal deviation (controls) and 14 patients with chronic rhinosinusitis without nasal polyps (CRSsNP). With regard to TGF-β1, with our primers, we could again only identify positive expression in a limited number of samples... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260149 Mon, 11 Jan 2010 00:00:00 +0100 3260149 http://www.medworm.com/index.php?rid=3260148&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909015425%2Fabstract%3Frss%3Dyes To the Editor: The authors of the article entitled “Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese” claim to confirm our data on the deficit of forkhead box protein 3 (or T-regulatory cells) and a decreased production of TGF-β1 in Chinese patients with chronic rhinosinusitis with nasal polyps versus controls; they also claim that, in contrast with our findings in white patients, mucosal samples of patients with chronic rhinosinusitis without nasal polyps (CRSsNP) in China would be characterized by a decrease in T-regulatory cells and TGF-β expression. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260148 Mon, 11 Jan 2010 00:00:00 +0100 3260148 http://www.medworm.com/index.php?rid=3139670&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS009167490901817X%2Fabstract%3Frss%3Dyes With regard to the November 2009 article “Hydroxyurea in the treatment of Churg-Strauss syndrome” (J Allergy Clin Immunol 2009;124:1110-11), the legend for Figure 1 was mistakenly reprinted from another article in the same issue. The correct figure and legend are as follows: (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139670 Fri, 01 Jan 2010 00:00:00 +0100 3139670 http://www.medworm.com/index.php?rid=3139669&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909015802%2Fabstract%3Frss%3Dyes To the Editor: We thank Drs Incorvaia and Mauro as well as Drs Thompson and Morris for their comments on the 2 patients with systemic side effects to sublingual immunotherapy (SLIT) about whom we reported in a recent Letter to the Editor. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139669 Fri, 01 Jan 2010 00:00:00 +0100 3139669 http://www.medworm.com/index.php?rid=3139668&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909015826%2Fabstract%3Frss%3Dyes To the Editor: Drs Cochard and Eigenmann are to be applauded for bringing these case reports to light. They show the risk of starting sublingual immunotherapy at a high dose in sensitive patients. In defense of high-dose sublingual immunotherapy, the 14-year-old girl was also sensitive to tree pollens, and the ultrarush therapy for grass was in the context of tree pollen season, which may have primed an immunologic reaction. Further, the 13-year-old boy was sensitized to dust mite, grass, animal danders, and molds, whereas only grass and dust mite therapy were addressed. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139668 Fri, 01 Jan 2010 00:00:00 +0100 3139668 http://www.medworm.com/index.php?rid=3139667&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909015814%2Fabstract%3Frss%3Dyes To the Editor: The report by Cochard and Eigenmann highlights an important aspect of sublingual immunotherapy (SLIT): its safety in patients with previous reactions to subcutaneous immunotherapy. They describe 2 patients who withdrew from SLIT for repeated side effects with bronchial and nasal reactions, respectively. In both of them, previous subcutaneous immunotherapy treatment had to be discontinued for adverse reactions. This confirms a recent report on 2 patients with similar characteristics who had stopped subcutaneous immunotherapy because of adverse reactions and also had severe, anaphylactic reactions to SLIT. To complicate the issue, in all these patients, SLIT was not performed by conventional schedules: in the first case, an ultrarush schedule using the product Staloral 300 (S... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139667 Fri, 01 Jan 2010 00:00:00 +0100 3139667 http://www.medworm.com/index.php?rid=3139664&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909016340%2Fabstract%3Frss%3Dyes To the Editor: Environmental challenges during pregnancy and early life events have long been hypothesized to modulate the susceptibility to chronic diseases in later life, which is commonly referred to as “developmental programming.” The unprecedented rise of allergies occurring in industrialized countries over the past 5 decades and the recognition that prenatal and postnatal environmental factors are involved in the risk to develop allergies suggest that atopic diseases may be central in understanding mechanisms involved in developmental programming. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139664 Fri, 01 Jan 2010 00:00:00 +0100 3139664 http://www.medworm.com/index.php?rid=3139663&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909016066%2Fabstract%3Frss%3Dyes To the Editor: Available large-scale prospective studies on adiposity and asthma used body mass index as an indicator of adiposity. Studies involving more accurate measures of adiposity, such as body fat percentage (BF%), are needed to confirm or contrast body mass index–related results. Cardiorespiratory fitness is a strong predictor of morbidity and mortality, and the available literature suggests that moderate-high cardiorespiratory fitness reduces many of the health hazards associated with obesity. The current study aimed (1) to examine whether cardiorespiratory fitness and/or BF% are associated with subsequent acquisition of asthma in adults, and (2) to test the hypothesis that a high cardiorespiratory fitness level can reduce the risk of incident asthma in individuals with excess ... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139663 Fri, 01 Jan 2010 00:00:00 +0100 3139663 http://www.medworm.com/index.php?rid=3139662&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909015656%2Fabstract%3Frss%3Dyes To the Editor: Rotavirus infections in the United States have decreased as a result of vaccination efforts. Before 2006, when the vaccine was implemented, the burden of disease was high, with approximately 27,000 to 70,000 children under 5 years of age hospitalized with rotavirus infection and about 20 to 60 reported deaths annually according to the Centers for Disease Control and Prevention and other studies. Since the introduction of vaccination, rotavirus rates in the United States have diminished by more than 50%, translating to the prevention of 48,000 hospitalizations and 30 deaths. Studies have also shown a delay in the seasonal onset of the disease by 2 to 4 months. Cost savings to the medical community with the vaccines are estimated to be as much as $198,000 per life-year. The q... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139662 Fri, 01 Jan 2010 00:00:00 +0100 3139662 http://www.medworm.com/index.php?rid=3139661&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909015413%2Fabstract%3Frss%3Dyes To the Editor: Churg-Strauss syndrome (CSS) is a primary small vessel vasculitis characterized by asthma, eosinophilia, multiorgan involvement (lung, peripheral nerves, heart, gastrointestinal tract, skin), and the possible presence of antineutrophil cytoplasmic antibodies (ANCAs). Corticosteroids alone are the classic therapeutic regimen in the absence of poor prognostic factors, and use of cyclophosphamide is recommended for severe disease or corticosteroid-resistant cases. The other therapies tried in CSS (intravenous immunoglobulins, IFN-α, infliximab, rituximab) target the putative pathogenic pathways of ANCA-associated vasculitides without consideration for the hallmarks of CSS compared with other ANCA-associated vasculitides: important blood and tissue eosinophilia and lower preva... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139661 Fri, 01 Jan 2010 00:00:00 +0100 3139661 http://www.medworm.com/index.php?rid=3139657&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909015632%2Fabstract%3Frss%3Dyes Conclusion: Discovery of a novel TH2 regulatory pathway linking FcγRI signaling to TSLP receptor upregulation and consequent TSLP-mediated effects questions the validity of receptor-targeted allergen vaccines. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139657 Fri, 01 Jan 2010 00:00:00 +0100 3139657 http://www.medworm.com/index.php?rid=3139656&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909015541%2Fabstract%3Frss%3Dyes Conclusion: Treg cells not only modulate ongoing CD4+T cell–mediated immune reactions at tissue sites but also abrogate the de novo induction of CD8+T cell–driven immune reactions by interfering with T-cell stimulatory activity of DCs through gap junctional intercellular communication. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139656 Fri, 01 Jan 2010 00:00:00 +0100 3139656 http://www.medworm.com/index.php?rid=3139655&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909015371%2Fabstract%3Frss%3Dyes Conclusion: The current study is the first to address the potential effect-modifying role of genetic variations in the relationship between the intestinal microbiota and allergy development. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139655 Fri, 01 Jan 2010 00:00:00 +0100 3139655 http://www.medworm.com/index.php?rid=3139654&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909015383%2Fabstract%3Frss%3Dyes Conclusion: Because of its peculiar functional properties and the increased numbers in the circulation of patients with bronchial asthma, this previously unknown population of TH17/TH2 cells may play some role in the pathogenesis of this disease. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139654 Fri, 01 Jan 2010 00:00:00 +0100 3139654 http://www.medworm.com/index.php?rid=3139653&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS009167490901611X%2Fabstract%3Frss%3Dyes Conclusion: Like asthma, other atopic conditions, particularly atopic dermatitis, are associated with an increased risk of SPD. There may be a common immunogenetic mechanism underlying increased risk of SPD among individuals with either asthma or other atopic conditions. Our study findings need to be studied further. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139653 Fri, 01 Jan 2010 00:00:00 +0100 3139653 http://www.medworm.com/index.php?rid=3139652&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909015516%2Fabstract%3Frss%3Dyes Conclusion: Overall, these results suggest a defect of regulatory T cells in OS leading to a breakdown of peripheral tolerance, which may actively concur to the development of autoimmune manifestations in the disease. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139652 Fri, 01 Jan 2010 00:00:00 +0100 3139652 http://www.medworm.com/index.php?rid=3139649&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909015346%2Fabstract%3Frss%3Dyes Conclusion: The majority of children considered peanut-sensitized on the basis of standard tests do not have peanut allergy. Component-resolved diagnostics may facilitate the diagnosis of peanut allergy. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139649 Fri, 01 Jan 2010 00:00:00 +0100 3139649 http://www.medworm.com/index.php?rid=3139646&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909016121%2Fabstract%3Frss%3Dyes Conclusion: Single nucleotide polymorphism rs7927894 appears to mark a genuine eczema susceptibility locus that will require further elucidation through fine mapping and functional analysis. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139646 Fri, 01 Jan 2010 00:00:00 +0100 3139646 http://www.medworm.com/index.php?rid=3139644&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909015528%2Fabstract%3Frss%3Dyes Conclusion: This study identified groups of innate immunity genes that are associated with the aberrant response of AD skin to VV and represent potential targets for EV pathogenesis. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139644 Fri, 01 Jan 2010 00:00:00 +0100 3139644 http://www.medworm.com/index.php?rid=3139641&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909015838%2Fabstract%3Frss%3Dyes Conclusion: Three years of treatment with the SQ-standardized grass allergy immunotherapy tablet resulted in consistent clinical improvement and accompanying immunologic changes that were sustained 1 year after treatment, which is indicative of disease modification and associated long-term benefits. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139641 Fri, 01 Jan 2010 00:00:00 +0100 3139641 http://www.medworm.com/index.php?rid=3139637&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909017254%2Fabstract%3Frss%3Dyes Studies on wheezing or asthma in Africa have consistently shown low levels in the villages and increasing prevalence with urbanization. In many of those studies, the authors focused on differences in helminth infection to explain the changes in the prevalence of wheezing. The arguments for this approach are that infestation is common, helminths are known to induce IgE responses, and children in rural Africa generally have high total serum IgE levels despite a low prevalence of allergic symptoms. In contrast, helminths might be less common in many towns because of greater access to sanitation and anthelmintic drugs. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139637 Fri, 01 Jan 2010 00:00:00 +0100 3139637 http://www.medworm.com/index.php?rid=3139635&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909017916%2Fabstract%3Frss%3Dyes Seasonal allergic rhinitis affects 20% to 25% of the populations of Europe and the United States and has a considerable influence on quality of life in addition to being an independent risk factor for asthma. Specific immunotherapy is the only treatment modality with the potential to modify the course of this disease and provide sustained efficacy in post-treatment years. In a study by Durham et al (p 131), the sustained efficacy after a 3-year period with grass allergy immunotherapy tablet treatment was evaluated 1 year after completion of treatment. Statistically significant and clinically relevant differences in the primary end points in comparison with placebo were found at the 1-year follow-up (see Figure). Significant improvements in quality of life were also reported, both during t... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139635 Fri, 01 Jan 2010 00:00:00 +0100 3139635 http://www.medworm.com/index.php?rid=3139634&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909017539%2Fabstract%3Frss%3Dyes This review highlights some of the research advances in anaphylaxis and hypersensitivity reactions to foods, drugs, and insects, as well as advances in allergic skin disease that were reported in the Journal in 2009. Among key epidemiologic observations, several westernized countries report that more than 1% of children have peanut allergy, and there is some evidence that environmental exposure to peanut is a risk factor. The role of regulatory T cells, complement, platelet-activating factor, and effector cells in the development and expression of food allergy were explored in several murine models and human studies. Delayed anaphylaxis to mammalian meats appears to be related to IgE binding to the carbohydrate moiety galactose-α-1,3-galactose, which also has implications for hypersensiti... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139634 Fri, 01 Jan 2010 00:00:00 +0100 3139634 http://www.medworm.com/index.php?rid=3139633&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909017497%2Fabstract%3Frss%3Dyes There is a growing need to standardize and validate outcomes for asthma research. In this review of asthma-related publications from the Journal in 2009, efforts to standardize methodology and reporting of translational research, the influence of the environment, therapeutics, and management of asthma are highlighted. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139633 Fri, 01 Jan 2010 00:00:00 +0100 3139633 http://www.medworm.com/index.php?rid=3139632&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909017205%2Fabstract%3Frss%3Dyes This year's summary will focus on recent advances in pediatric asthma as reported in Journal of Allergy and Clinical Immunology publications in 2009. New National Asthma Education and Prevention Program asthma guidelines were released in 2007, with a particular emphasis on asthma control. Now that we have worked with the principals of the guidelines for 2 years, new insights are reported on how to implement the guidelines into clinical practice. This year's report will focus on gaps in management that need to be addressed, including health disparities, methods to improve asthma management through opportunities available in school-based asthma programs, and more information on the development of asthma in childhood. This information brings us closer to the point of managing children with co... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139632 Fri, 01 Jan 2010 00:00:00 +0100 3139632 http://www.medworm.com/index.php?rid=3139631&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909017370%2Fabstract%3Frss%3Dyes Natural killer (NK) cells are best known for their ability to recognize and kill tumor cells and virally infected cells and for their ability to produce large amounts of some cytokines, such as IFN-γ. Recent research has substantially expanded our view on the function of NK cells in the immune system in health and disease. In addition to the better-studied functions in cancer and autoimmunity, contributions from NK cells to allergies and various skin diseases have emerged. We briefly recount the traditional NK cell functions before focusing on their roles in atopic dermatitis, psoriasis, alopecia areata, and pemphigus vulgaris. Although this field is still developing, strong data are available that indicate NK cell involvement. In patients with allergic diseases, the production of TH2 cyt... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139631 Fri, 01 Jan 2010 00:00:00 +0100 3139631 http://www.medworm.com/index.php?rid=3139630&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909017369%2Fabstract%3Frss%3Dyes Much knowledge has been gained about the multifaceted functions of dendritic cells (DCs). The central role of various DC subtypes as bridges between innate and adaptive immunity has become more and more evident. However, a high number of differences exist in the expression of pattern-recognition receptors, the first sensors of the innate immune system, in particular Toll-like receptors (TLRs) by distinct DC subtypes (including myeloid and plasmacytoid DCs), their maturation stage, and tissue distribution, as well as state of health or disease. Furthermore, a plethora of variations in human and murine model systems have to be considered. This review sheds some light on this complex and rapidly growing field. It summarizes the most recent findings and deals with the role of TLR-expressing DC... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139630 Fri, 01 Jan 2010 00:00:00 +0100 3139630 http://www.medworm.com/index.php?rid=3139629&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909016054%2Fabstract%3Frss%3Dyes Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) strains have emerged as serious health threats in the last 15 years. They are associated with large numbers of atopic dermatitis skin and soft tissue infections, but when they originate from skin and mucous membranes, have the capacity to produce sepsis and highly fatal pulmonary infections characterized as necrotizing pneumonia, purpura fulminans, and postviral toxic shock syndrome. This review is a discussion of the emergence of 3 major CA-MRSA organisms, designated CA-MRSA USA400, followed by USA300, and most recently USA200. CA-MRSA USA300 and USA400 isolates and their methicillin-sensitive counterparts (community-associated methicillin-sensitive S aureus) typically produce highly inflammatory cytolysins α-toxi... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139629 Fri, 01 Jan 2010 00:00:00 +0100 3139629 http://www.medworm.com/index.php?rid=3139627&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909017461%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139627 Fri, 01 Jan 2010 00:00:00 +0100 3139627 http://www.medworm.com/index.php?rid=3139626&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909017229%2Fabstract%3Frss%3Dyes A genetic basis for atopic dermatitis (AD) has long been recognized. Historic documents allude to family history of disease as a risk factor. Before characterization of the human genome, heritability studies combined with family-based linkage studies supported the definition of AD as a complex trait in that interactions between genes and environmental factors and the interplay between multiple genes contribute to disease manifestation. A summary of more than 100 published reports on genetic association studies through mid-2009 implicates 81 genes, in 46 of which at least 1 positive association with AD has been demonstrated. Of these, the gene encoding filaggrin (FLG) has been most consistently replicated. Most candidate gene studies to date have focused on adaptive and innate immune respon... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139626 Fri, 01 Jan 2010 00:00:00 +0100 3139626 http://www.medworm.com/index.php?rid=3139625&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS009167490901745X%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139625 Fri, 01 Jan 2010 00:00:00 +0100 3139625 http://www.medworm.com/index.php?rid=3139624&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909017485%2Fabstract%3Frss%3Dyes Atopic dermatitis (AD) is a common complex disease that frequently follows a chronic relapsing course and affects the quality of life of patients and families in a significant manner. New insights into the pathophysiology of AD point to an important role of structural abnormalities in the epidermis combined with immune dysregulation. Patients with AD have a unique predisposition to colonization or infection by a number of microbial organisms, most notably Staphylococcus aureus and herpes simplex virus. A multipronged approach directed at healing or protecting the skin barrier and addressing the immune dysregulation is necessary to improve the likelihood of successful outcomes. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139624 Fri, 01 Jan 2010 00:00:00 +0100 3139624 http://www.medworm.com/index.php?rid=3139623&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909017722%2Fabstract%3Frss%3Dyes Gamble et al (Am J Respir Crit Care Med 2009;180:817-22) used pharmacy records to assess adherence with inhaled corticosteroid/long-acting β-agonist combination therapy in 182 patients referred to a difficult asthma clinic in Northern Ireland. Over the previous 6 months, 35% of the patients were found to have filled less than 50% of the medication prescriptions. Women were more apt to be nonadherent than men (42% vs 23%). Those less than 50% adherent had clinically meaningfully lower Asthma Quality of Life scores and were significantly more apt to have been hospitalized 3 or more times in the last year. When adherence to oral corticosteroids was assessed based on measurement of plasma prednisone and cortisol levels, 45% of the 51 patients were found to be nonadherent. Therefore before pre... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139623 Fri, 01 Jan 2010 00:00:00 +0100 3139623 http://www.medworm.com/index.php?rid=3139622&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909027444%2Fabstract%3Frss%3Dyes ▪ 2009 Virtual Annual Meeting: Unable to attend all of the sessions that you wanted to at the 2009 Annual Meeting? Couldn't make it to Washington, DC? Here is your chance to access the sessions you were not able to attend at your convenience. The 2009 Virtual Annual Meeting offers Webcasts and audio recordings of most Annual Meeting sessions. Earn over 129 CME or 150 CE credits! Credits will be offered until March 2011. For additional information or to place an order, visit annualmeeting.aaaai.org and select the link for “2009 Annual Meeting” from the Attendee tab. Funded through an educational grant from GlaxoSmithKline. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139622 Fri, 01 Jan 2010 00:00:00 +0100 3139622 http://www.medworm.com/index.php?rid=3139621&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909027432%2Fabstract%3Frss%3Dyes This month, Eugenia Hahn, MD, FAAAAI, took time to answer a few questions. Hahn is Chair of the AAAAI's New Allergist/Immunologist Assembly (NAIA). In what ways has membership in the AAAAI benefitted you?Being an active member of the AAAAI keeps me connected to a community of allergists. Also, as developments in the field unfold, being a member helps me to stay current with new ideas, methods and recommendations. For example, the AAAAI Web site has kept me informed regarding pertinent H1N1 information, and a recent broadcast email to members alerted me to the availability of PRE-PEN®. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139621 Fri, 01 Jan 2010 00:00:00 +0100 3139621 http://www.medworm.com/index.php?rid=3139620&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909027420%2Fabstract%3Frss%3Dyes Communications regarding original articles and editorial management should be addressed to Donald Y. M. Leung, MD, PhD, Editor in Chief, The Journal of Allergy and Clinical Immunology, National Jewish Medical and Research Center, 1400 Jackson St (J324), Denver, CO 80206; phone 303-398-1963; fax 303-270-2269. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139620 Fri, 01 Jan 2010 00:00:00 +0100 3139620 http://www.medworm.com/index.php?rid=3139619&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909027407%2Fabstract%3Frss%3Dyes Editor in Chief DONALD Y. M. LEUNG, MD, PhD Denver, Colo Deputy Editor STANLEY J. SZEFLER, MD Denver, Colo (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139619 Fri, 01 Jan 2010 00:00:00 +0100 3139619 http://www.medworm.com/index.php?rid=3139618&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909027390%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139618 Fri, 01 Jan 2010 00:00:00 +0100 3139618 http://www.medworm.com/index.php?rid=3139617&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909027377%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139617 Fri, 01 Jan 2010 00:00:00 +0100 3139617 http://www.medworm.com/index.php?rid=3139616&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909027365%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3139616 Fri, 01 Jan 2010 00:00:00 +0100 3139616 http://www.medworm.com/index.php?rid=3260147&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909027304%2Fabstract%3Frss%3Dyes To the Editor: With the death of Josiah F. Wedgwood on November 27, 2009, the primary immunodeficiency (PID) and autoimmunity research communities lost a strong advocate and a dear friend. Josiah received a Bachelors of Arts magna cum laude, 1971, and a PhD in Biochemistry and Molecular Biology, 1978, from Harvard University. He earned an MD from George Washington University School of Medicine in 1980 and trained in pediatrics and pediatric infectious diseases at New York Hospital/Cornell University Medical Center and in neonatology/perinatology at Long Island Jewish Medical Center. From 1991 to 1998, he was an assistant professor of Pediatrics at Mount Sinai Medical Center in New York. From 1998 until 2002, Josiah served as director of Newborn Services, Hospital of Saint Raphael at Yale M... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260147 Wed, 30 Dec 2009 00:00:00 +0100 3260147 http://www.medworm.com/index.php?rid=3260136&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674909014043%2Fabstract%3Frss%3Dyes Conclusion: Focus formation generated by accumulating antigen-specific TH2 cells in the lung appeared to be a critical process in the initiation of the asthma phenotype. This new model enables the study of in vivo cell biology of airway inflammation and novel drug discovery for lung inflammatory diseases. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=3260136 Fri, 25 Dec 2009 00:00:00 +0100 3260136