MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Journal of Allergy and Clinical Immunology' source. Wed, 08 Feb 2012 06:42:55 +0100 http://www.medworm.com/index.php?rid=5646666&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911019531%2Fabstract%3Frss%3Dyes With regard to the February 2011 article entitled “The burden of adult asthma in the United States: Evidence from the Medical Expenditure Panel Survey” (J Allergy Clin Immunol 2011;127:363-9.e3), several numbers need to be corrected. First, the initial sentence of the Results section, both in the abstract and in the body of the article, should read “Of 44,795 adults, 1,935 reported an encounter for asthma.” Second, in , the Proportion rows for all headings other than “Adult MEPS total” are incorrect as given. A corrected version of the Table appears below: (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646666 Wed, 01 Feb 2012 05:00:00 +0100 5646666 http://www.medworm.com/index.php?rid=5646648&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911029368%2Fabstract%3Frss%3Dyes To date, allergen-specific immunotherapy (ASIT) is the only causal treatment for allergic diseases. The principle of ASIT is to administer gradually increasing doses of allergen, either as allergen extracts or as recombinant allergen. The aim is to reprogram the allergen-specific immune response from a TH2-driven IgE-dominated response toward a tolerant state. By inducing immune tolerance to an allergen, diseases such as allergic rhinitis might even be prevented in progressing toward a severe chronic disorder, such as asthma. Although the concept of specific immunotherapy is more than 100 years old, our knowledge about the underlying immunologic mechanisms is limited (for overview, see ). Moreover, some patients are clinically unresponsive to ASIT, and the identification of solid predictor... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646648 Wed, 01 Feb 2012 05:00:00 +0100 5646648 http://www.medworm.com/index.php?rid=5646634&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911029381%2Fabstract%3Frss%3Dyes The importance of the human microbiome is rapidly emerging. Our bodies host complex communities of microbes with much greater genetic diversity than our own genome. This complexity is variable across subjects, and there is still much to learn about the processes that drive the establishment and maintenance of these communities. More importantly, these communities fundamentally affect the normal function of our bodies and thus are critical to understand as modifiers of human processes, including disease. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646634 Wed, 01 Feb 2012 05:00:00 +0100 5646634 http://www.medworm.com/index.php?rid=5646626&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911019695%2Fabstract%3Frss%3Dyes With regard to the August 2011 article entitled “Tiotropium is noninferior to salmeterol in maintaining improved lung function in B16-Arg/Arg patients with asthma” (J Allergy Clin Immunol 2011;128:315-22), a full list of the investigators and other important participants who contributed to the study has been added to the article’s Supplemental Materials section on the Journal’s Web site (www.jacionline.org). (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646626 Wed, 01 Feb 2012 05:00:00 +0100 5646626 http://www.medworm.com/index.php?rid=5646619&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911029290%2Fabstract%3Frss%3Dyes Allergic rhinitis or hay fever is a common disease caused by environmental allergens, such as pollens and animal dander, in allergic persons. Characteristic symptoms include runny nose, nasal itching, sneezing, and congestion. Antihistamines that block the first of 4 different receptors, molecules that mediate the effects of histamine released during allergies, are available over the counter and by prescription. These antihistamines are effective in treating allergic rhinitis–associated itching, runny nose, and sneezing but are not very effective against nasal congestion, often the most bothersome symptom. A number of decongestants are available either alone or in combination with these antihistamines, but they are not completely effective in treating nasal congestion either, and they of... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646619 Wed, 01 Feb 2012 05:00:00 +0100 5646619 http://www.medworm.com/index.php?rid=5646617&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS009167491102937X%2Fabstract%3Frss%3Dyes 2011 was marked by rapid progress in the identification of basic mechanisms of allergic disease and the translation of these mechanisms into human cell systems. Studies published in the Journal of Allergy and Clinical Immunology this year provided new insights into the molecular determinants of allergenicity, as well as the environmental, cellular, and genetic factors involved in sensitization to allergens. Several articles focused on mechanisms of allergen immunotherapy and the development of novel strategies to achieve tolerance to allergens. Additional studies identified substantial contributions from TH17-type cells and cytokines to human disease pathogenesis. Finally, new therapeutic applications of anti-IgE were identified. The highlights of these studies and their potential clinical... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646617 Wed, 01 Feb 2012 05:00:00 +0100 5646617 http://www.medworm.com/index.php?rid=5646616&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS009167491102940X%2Fabstract%3Frss%3Dyes Access to an electronic medical record is essential for personalized medicine. Currently, only 40% of US physicians have such access, but this is rapidly changing. It is expected that 100,000 Americans will have their whole genome sequenced in 2012. The cost of such sequencing is rapidly dropping, and is estimated to be $1000 by 2013. These technological advances will make interpretation of whole genome sequence data a major clinical challenge for the foreseeable future. At present, a relatively small number of genes have been identified to determine drug treatment response phenotypes for asthma. It is anticipated that this will dramatically increase over the next 10 years as personalized medicine becomes more of a reality for asthma patients. (Source: Journal of Allergy and Clinical Immun... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646616 Wed, 01 Feb 2012 05:00:00 +0100 5646616 http://www.medworm.com/index.php?rid=5646613&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911029411%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646613 Wed, 01 Feb 2012 05:00:00 +0100 5646613 http://www.medworm.com/index.php?rid=5646611&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911029605%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646611 Wed, 01 Feb 2012 05:00:00 +0100 5646611 http://www.medworm.com/index.php?rid=5646609&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911030168%2Fabstract%3Frss%3Dyes Rob C. Aalberse∗ Jun Abe (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646609 Wed, 01 Feb 2012 05:00:00 +0100 5646609 http://www.medworm.com/index.php?rid=5646608&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911029460%2Fabstract%3Frss%3Dyes Previous research on reslizumab, an anti–IL-5 mAb, in asthmatic patients did not provide a clear clinical benefit; however, improvements were noted in small studies in subgroups of patients with eosinophilic asthma. Castro et al (Am J Respir Crit Care Med 2011;184:1125-32) investigated reslizumab's effectiveness in 106 patients with uncontrolled asthma with eosinophilia exclusively. The primary outcome (asthma control questionnaire) was not significantly improved. However, the authors found that airway function improved and sputum and blood eosinophilia decreased in the reslizumab-treated group. Moreover, they reported a novel finding. Patients with nasal polyposis had a statistically significant improvement in asthma control compared with those without polyposis. Thus there might be a s... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646608 Wed, 01 Feb 2012 05:00:00 +0100 5646608 http://www.medworm.com/index.php?rid=5646607&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911029691%2Fabstract%3Frss%3Dyes ▪ Online Teaching Slide Presentations (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646607 Wed, 01 Feb 2012 05:00:00 +0100 5646607 http://www.medworm.com/index.php?rid=5646606&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS009167491102968X%2Fabstract%3Frss%3Dyes For this month's interview, we talked with Stuart L. Abramson, MD, PhD, AE-C, FAAAAI, the incoming chair of the Annual Meeting Program Committee (AMPC). Dr. Abramson leads the Allergy/Immunology Service at Shannon Medical Center in San Angelo, TX. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646606 Wed, 01 Feb 2012 05:00:00 +0100 5646606 http://www.medworm.com/index.php?rid=5646605&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911029678%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646605 Wed, 01 Feb 2012 05:00:00 +0100 5646605 http://www.medworm.com/index.php?rid=5646604&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911029654%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646604 Wed, 01 Feb 2012 05:00:00 +0100 5646604 http://www.medworm.com/index.php?rid=5646603&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911029642%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646603 Wed, 01 Feb 2012 05:00:00 +0100 5646603 http://www.medworm.com/index.php?rid=5646602&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911029630%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646602 Wed, 01 Feb 2012 05:00:00 +0100 5646602 http://www.medworm.com/index.php?rid=5646601&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911029617%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646601 Wed, 01 Feb 2012 05:00:00 +0100 5646601 http://www.medworm.com/index.php?rid=5646665&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911019026%2Fabstract%3Frss%3Dyes We appreciate the comments by Lowe et al on our article entitled “Mode and place of delivery, gastrointestinal microbiota, and their influence on asthma and atopy.” The authors suggest that we “claim that C difficile might cause allergic disease.” In our article the only strong causal claim concerns the role of delivery: “The findings of mediation by C difficile strengthen the evidence for a causal role of birth mode on atopic manifestations through influencing the GM composition.” The term “birth mode” in this sentence might be confusing because it was meant to refer to both birth mode and place. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646665 Fri, 30 Dec 2011 05:00:00 +0100 5646665 http://www.medworm.com/index.php?rid=5646664&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911019014%2Fabstract%3Frss%3Dyes van Nimwegen et al report an intriguing set of results concerning the role of intestinal microbiota colonization in the relationship between mode and place of delivery on childhood risk of allergic disease. The possibility of cesarean section being a potential cause of asthma has received considerable attention, and although other hypotheses have been posed, the most often cited explanation for this association is reduced colonization with microbiota from the maternal gut and vagina. The authors observed that, of the measured microbiota, only colonization by Clostridium difficile was related to the risk of allergic disease. It is worth noting that this observation is slightly different from the initial interpretation of the hygiene hypothesis, which suggested that lack of colonization rat... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646664 Fri, 30 Dec 2011 05:00:00 +0100 5646664 http://www.medworm.com/index.php?rid=5646646&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911018392%2Fabstract%3Frss%3Dyes Conclusion: The PGD2/PGJ2-peroxisome proliferator–activated receptor gamma pathway induces eotaxin production from sebocytes, which may explain the massive eosinophil infiltrates observed around pilosebaceous units in EPF. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646646 Fri, 30 Dec 2011 05:00:00 +0100 5646646 http://www.medworm.com/index.php?rid=5646637&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911019063%2Fabstract%3Frss%3Dyes Conclusion: Reslizumab significantly reduced intraepithelial esophageal eosinophil counts in children and adolescents with eosinophilic esophagitis. However, improvements in symptoms were observed in all treatment groups and were not associated with changes in esophageal eosinophil counts. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646637 Fri, 30 Dec 2011 05:00:00 +0100 5646637 http://www.medworm.com/index.php?rid=5646625&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911018975%2Fabstract%3Frss%3Dyes Conclusions: Children with severe asthma have increased airway TGF-β1 expression and activation associated with an increased airway oxidant burden. Oxidant stress might mediate the effects of TGF-β1 and promote airway remodeling in children with severe asthma. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646625 Fri, 30 Dec 2011 05:00:00 +0100 5646625 http://www.medworm.com/index.php?rid=5646618&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911019555%2Fabstract%3Frss%3Dyes Investigations of basic immunologic mechanisms and clinical studies of primary immunodeficiencies were most prevalent in 2011. Significant progress was achieved in the characterization of TH17 cell differentiation and associated cytokines in the setting of inflammatory disorders, HIV infection, and immunodysregulation disorders. The role of transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) mutations in the pathogenesis of CVID was further described and reported to be likely mediated by impaired TACI expression affecting B-cell function. The frequency of autoimmunity in patients with partial DiGeorge syndrome was estimated at 8.5%, predominantly resulting in blood cytopenias and hypothyroidism. Several reports emphasized the presentation of neoplasias, m... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646618 Fri, 30 Dec 2011 05:00:00 +0100 5646618 http://www.medworm.com/index.php?rid=5646615&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911019002%2Fabstract%3Frss%3Dyes Fungal infections of the nose and paranasal sinuses represent a spectrum of diseases ranging from colonization to invasive rhinosinusitis. Clinical manifestations are largely dependent on the immune status of the host, and given the ubiquitous nature of these organisms, exposure is unavoidable. Noninvasive disease includes asymptomatic fungal colonization, fungus balls, and allergic fungal rhinosinusitis. Invasive disease includes indolent chronic rhinosinusitis, granulomatous fungal sinusitis, and acute fulminant fungal rhinosinusitis. A differentiation of these somewhat overlapping syndromes and the disparate treatment regimens required for effective management are the focus of this review. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646615 Fri, 30 Dec 2011 05:00:00 +0100 5646615 http://www.medworm.com/index.php?rid=5543897&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS009167491101654X%2Fabstract%3Frss%3Dyes Credit can now be obtained, free for a limited time, by reading the review articles in this issue. Please note the instructions listed below: (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543897 Tue, 27 Dec 2011 23:54:41 +0100 5543897 http://www.medworm.com/index.php?rid=5543896&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911017490%2Fabstract%3Frss%3Dyes With regard to the November 2011 article entitled “Test for Respiratory and Asthma Control in Kids (TRACK): Clinically meaningful changes in score” (J Allergy Clin Immunol 2011;128:983-8): Typographical errors require that changes be made to the answer choices for , Questions 3 and 5. This figure shows the Test for Respiratory and Asthma Control in Kids (TRACK™) tool. The correct answer choices for Question 3, which reads “During the past 4 weeks, to what extent did your child's breathing problems, such as wheezing, coughing, or shortness of breath, interfere with his or her ability to play, go to school, or engage in usual activities that a child should be doing at his or her age” are as follows: “Not at all,” “Slightly,” “Moderately,” “Quite a lot,” and “Extre... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543896 Tue, 27 Dec 2011 23:54:41 +0100 5543896 http://www.medworm.com/index.php?rid=5543883&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911017945%2Fabstract%3Frss%3Dyes To the Editor: Respiratory complications caused by ozone (O3) represent a significant public health burden. O3 and a range of other pollutants are thought to exert their effects through oxidative stress responses in the lower airway. Despite studies suggesting that pulmonary oxidative insults by air pollutants lead to deleterious health outcomes, treatment options for environmentally induced oxidative stress are limited, partially because of the lack of understanding of exactly how these pollutants affect susceptible populations. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543883 Tue, 27 Dec 2011 23:54:41 +0100 5543883 http://www.medworm.com/index.php?rid=5543866&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911017982%2Fabstract%3Frss%3Dyes IL-10 belongs to the IL-10 family of cytokines, consisting of IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, IL-28A, IL-28B, and IL-29. Mature IL-10 forms homodimers, which bind to IL-10 receptor consisting of α (IL-10Rα, also termed IL-10R1) and β (IL-10Rβ, also termed IL-10R2) chains, thus activating the Janus kinase–signal transducer and activator of transcription signaling pathway, notably Janus kinase 1, tyrosine kinase 2, and signal transducer and activator of transcription 3 and 1. The main function of IL-10 appears to be the prevention of extensive tissue damage after inflammation and infection. In addition, T-cell responses to allergens upon allergen-specific immunotherapy, high-dose allergen exposure, and chronic viral infections have been shown to be suppressed by IL-10 signals... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543866 Tue, 27 Dec 2011 23:54:41 +0100 5543866 http://www.medworm.com/index.php?rid=5543856&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911018227%2Fabstract%3Frss%3Dyes Patients with chronic granulomatous disease (CGD) have impaired quality of life and early mortality, even with vigorous infection prophylaxis. Hematopoietic stem cell transplantation (HSCT) from an HLA-matched related donor is curative but is available to just 25% of patients. Transplantation from a matched unrelated donor has been successfully used to treat other primary immunodeficiencies, but scant data are available for patients with CGD. In this issue Martinez et al (p 176) report 100% survival for 11 patients receiving HSCT after conditioning with busulfan, cyclophosphamide, cytarabine or fludarabine, and alemtuzumab. Strikingly, the majority of these patients were successfully treated with matched unrelated donor grafts (n = 7). Neutrophil and platelet engraftment was achieved at a... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543856 Tue, 27 Dec 2011 23:54:41 +0100 5543856 http://www.medworm.com/index.php?rid=5543855&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911018057%2Fabstract%3Frss%3Dyes This review highlights some of the research advances in anaphylaxis; hypersensitivity reactions to foods, drugs, and insects; and allergic skin diseases that were reported in the Journal in 2011. Food allergy appears to be increasing in prevalence and carries a strong economic burden. Risk factors can include dietary ones, such as deficiency of vitamin D and timing of complementary foods, and genetic factors, such as filaggrin loss-of-function mutations. Novel mechanisms underlying food allergy include the role of invariant natural killer T cells and influences of dietary components, such as isoflavones. Among numerous preclinical and clinical treatment studies, promising observations include the efficacy of sublingual and oral immunotherapy, a Chinese herbal remedy showing promising in v... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543855 Tue, 27 Dec 2011 23:54:41 +0100 5543855 http://www.medworm.com/index.php?rid=5543853&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911017994%2Fabstract%3Frss%3Dyes Last year’s “Advances in pediatric asthma” concluded with the following statement: “Perhaps new directions in personalized medicine and improved health care access and communication will help maintain steady progress in alleviating the burden of this disease in children, especially young children.” This year’s summary will focus on recent advances in pediatric asthma that show significant accomplishments in reducing asthma morbidity and mortality over the last 10 years and discuss some pathways to further reduce asthma burden, as indicated in Journal of Allergy and Clinical Immunology publications in 2011. Some of the recent reports continue to shed light on methods to improve asthma management through steps to reduce asthma exacerbations, identify features of the disease in ea... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543853 Tue, 27 Dec 2011 23:54:41 +0100 5543853 http://www.medworm.com/index.php?rid=5543852&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911017933%2Fabstract%3Frss%3Dyes Effective treatment of severe asthma is a major unmet need because patients’ symptoms are not controlled on maximum treatment with inhaled therapy. Asthma symptoms can be poorly controlled because of poor adherence to controller therapy, and this might be addressed by using combination inhalers that contain a corticosteroid and long-acting β2-agonist as reliever therapy in addition to maintenance treatment. New bronchodilators with a longer duration of action are in development, and recent studies have demonstrated the benefit of a long-acting anticholinergic bronchodilator in addition to β2-agonists in patients with severe asthma. Anti-IgE therapy is beneficial in selected patients with severe asthma. Several new blockers of specific mediators, including prostaglandin D2, IL-5, IL-9, ... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543852 Tue, 27 Dec 2011 23:54:41 +0100 5543852 http://www.medworm.com/index.php?rid=5543851&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911018367%2Fabstract%3Frss%3Dyes The prevalence of asthma and allergic diseases has been found to be increasingly rapidly, especially in developing countries. Environmental factors have been found to be important contributors to the manifestations of allergic diseases. Air pollution has been extensively studied in different regions of the world. The levels of ambient air pollutants in many Asian countries are very high when compared with those in developed Western countries. However, the prevalence of asthma was relatively low across many Asian countries. Many studies have clearly documented that environmental air pollution is an important factor resulting in exacerbations of asthma. In particular, levels of traffic-related pollutants are increasing rapidly across many Asian countries in parallel with the level of urbaniz... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543851 Tue, 27 Dec 2011 23:54:41 +0100 5543851 http://www.medworm.com/index.php?rid=5543850&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911017957%2Fabstract%3Frss%3Dyes Ambient air pollution, including particulate matter (PM) and gaseous pollutants, represents important environmental exposures that adversely affect human health. Because of their heritable and reversible nature, epigenetic modifications provide a plausible link between the environment and alterations in gene expression that might lead to disease. Epidemiologic evidence supports that environmental exposures in childhood affect susceptibility to disease later in life, supporting the belief that epigenetic changes can affect ongoing development and promote disease long after the environmental exposure has ceased. Indeed, allergic disorders often have their roots in early childhood, and early exposure to PM has been strongly associated with the subsequent development of asthma. The purpose of ... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543850 Tue, 27 Dec 2011 23:54:41 +0100 5543850 http://www.medworm.com/index.php?rid=5543848&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911018288%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543848 Tue, 27 Dec 2011 23:54:41 +0100 5543848 http://www.medworm.com/index.php?rid=5543846&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911018276%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543846 Tue, 27 Dec 2011 23:54:41 +0100 5543846 http://www.medworm.com/index.php?rid=5543844&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911018355%2Fabstract%3Frss%3Dyes Pregnancy and early life are a critical period of developmental immune and tissue programming for future diseases. As discussed in our first 2 summaries this month, evidence is accumulating indicating a mother's atopic status affects the immune development of the neonate, either in utero or postpartum, and that environmental tobacco smoke (ETS) has a great effect. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543844 Tue, 27 Dec 2011 23:54:41 +0100 5543844 http://www.medworm.com/index.php?rid=5543843&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911018665%2Fabstract%3Frss%3Dyes ▪ Online Teaching Slide Presentations (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543843 Tue, 27 Dec 2011 23:54:41 +0100 5543843 http://www.medworm.com/index.php?rid=5543842&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911018653%2Fabstract%3Frss%3Dyes For this month's installment, we interviewed Dorothy S. Cheung, MD, FAAAAI, chair of the AAAAI's New Allergist/Immunologist Assembly (NAIA). Dr. Cheung is Assistant Professor at the Medical College of Wisconsin. The NAIA is the AAAAI community for nearly 700 allergist/immunologists who have completed fellowship training within the last five years. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543842 Tue, 27 Dec 2011 23:54:41 +0100 5543842 http://www.medworm.com/index.php?rid=5543841&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911019099%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543841 Tue, 27 Dec 2011 23:54:41 +0100 5543841 http://www.medworm.com/index.php?rid=5543840&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911019075%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543840 Tue, 27 Dec 2011 23:54:41 +0100 5543840 http://www.medworm.com/index.php?rid=5543839&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911018434%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543839 Tue, 27 Dec 2011 23:54:41 +0100 5543839 http://www.medworm.com/index.php?rid=5543838&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911018422%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543838 Tue, 27 Dec 2011 23:54:41 +0100 5543838 http://www.medworm.com/index.php?rid=5543837&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911018409%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543837 Tue, 27 Dec 2011 23:54:41 +0100 5543837 http://www.medworm.com/index.php?rid=5646663&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911018331%2Fabstract%3Frss%3Dyes We thank Drs Mattheij and de Vries for their interesting communication on the diagnosis of β-lactam allergy in children. These results support our findings that β-lactam allergy is clearly overdiagnosed among children developing a benign maculopapular or urticarial rash during β-lactam treatment. Indeed, these skin rashes are only rarely reproducible by a subsequent challenge, and most of them are probably of viral origin. In this situation, several studies including ours have shown that an oral challenge test without prior skin testing is a safe procedure and is currently the best diagnostic tool for confirming a causal relationship between drug administration and an adverse reaction. However, it is to be noted that the clinician should be certain that the initial reaction was a delaye... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646663 Mon, 26 Dec 2011 05:00:00 +0100 5646663 http://www.medworm.com/index.php?rid=5646662&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS009167491101832X%2Fabstract%3Frss%3Dyes With great interest we read the article “The role of penicillin in benign skin rashes in childhood: a prospective study based on drug rechallenge” by Caubet et al. The authors studied the etiology of delayed-onset rashes in children treated with β-lactam antibiotics. They state that β-lactam allergy is clearly overdiagnosed. They advise oral provocation in all children suspected of antibiotic allergy, a statement in concurrence with the policy of the European Network of Drug Allergy. The few available studies about children with a suspected antibiotic allergy confirm this. They show that intradermal skin testing can be used to demonstrate a direct hypersensitivity reaction, but not a delayed-onset reaction, and confirm a high number of false-negative reactions. IgE assays show low s... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646662 Mon, 26 Dec 2011 05:00:00 +0100 5646662 http://www.medworm.com/index.php?rid=5646645&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS009167491101829X%2Fabstract%3Frss%3Dyes Conclusions: HDM allergens can induce glandular secretion in patients with AR, CRS, or both, and PAR2 represents a possible mechanism for nonspecific hyperreactivity in inflammatory airway diseases. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646645 Mon, 26 Dec 2011 05:00:00 +0100 5646645 http://www.medworm.com/index.php?rid=5646629&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911018318%2Fabstract%3Frss%3Dyes Conclusions: In combination with fexofenadine, single doses of PF-03654746 caused a reduction in allergen-induced nasal symptoms. H3 receptor antagonism might be a novel therapeutic strategy to further explore in patients with allergic rhinitis. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646629 Mon, 26 Dec 2011 05:00:00 +0100 5646629 http://www.medworm.com/index.php?rid=5646620&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911017970%2Fabstract%3Frss%3Dyes Conclusion: Intense, long-term swimming training in indoor chlorinated swimming pools is associated with airway changes similar to those seen in mild asthma, but with higher mucin expression. These changes were independent from airway hyperresponsiveness. The long-term physiological and clinical consequences of these changes remain to be clarified. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646620 Mon, 26 Dec 2011 05:00:00 +0100 5646620 http://www.medworm.com/index.php?rid=5646614&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911018306%2Fabstract%3Frss%3Dyes Conclusions: A consensus for the management of female patients with HAE-C1-INH is presented. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646614 Mon, 26 Dec 2011 05:00:00 +0100 5646614 http://www.medworm.com/index.php?rid=5646624&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911018215%2Fabstract%3Frss%3Dyes Conclusions: Current asthma control is associated with markers of small-airways disease. Improvements in ventilation heterogeneity with anti-inflammatory therapy are associated with improvements in symptoms. Sensitive measures of small-airway function might be useful in monitoring the response to therapy in asthmatic subjects. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646624 Thu, 22 Dec 2011 05:00:00 +0100 5646624 http://www.medworm.com/index.php?rid=5646632&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911017386%2Fabstract%3Frss%3Dyes Conclusion: Our study suggests that IL-31 is an important regulator of keratinocyte differentiation and demonstrates a link between the presence of IL-31 in skin, as found in patients with AD, and filaggrin expression. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646632 Mon, 19 Dec 2011 05:00:00 +0100 5646632 http://www.medworm.com/index.php?rid=5646631&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911017416%2Fabstract%3Frss%3Dyes Conclusion: Our data support that acquiring a cat in adulthood nearly doubles the risk of developing cat sensitization. Hence, cat avoidance should be considered in adults, especially in those sensitized to other allergens and reporting a history of allergic diseases. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646631 Mon, 12 Dec 2011 05:00:00 +0100 5646631 http://www.medworm.com/index.php?rid=5646633&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911016575%2Fabstract%3Frss%3Dyes Conclusion: Low intestinal microbial diversity during the first month of life was associated with subsequent atopic eczema. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646633 Thu, 08 Dec 2011 05:00:00 +0100 5646633 http://www.medworm.com/index.php?rid=5646636&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911016551%2Fabstract%3Frss%3Dyes Conclusion: OIT was more efficacious for desensitization to CM than SLIT alone but was accompanied by more systemic side effects. Clinical desensitization was lost in some cases within 1 week off therapy. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646636 Thu, 01 Dec 2011 05:00:00 +0100 5646636 http://www.medworm.com/index.php?rid=5543854&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911017519%2Fabstract%3Frss%3Dyes Last year’s review of research advances in adults with asthma emphasized the linear trajectory of translation: the initial studies translating bench findings to the first patients (T1) are connected to larger efficacy studies, including clinical trials studying subjects under tightly controlled conditions (T2), and these in turn are connected to research, including comparative effectiveness research, that tests how the efficacy findings of T2 research fare in the real world, diverse populations, and varied practice settings (T3). This year what was observed was a more interwoven relationship (rather than a linear one), in which each translational level informs the others and new approaches to answering old questions have led to new discoveries. Within this framework, the present review s... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543854 Thu, 01 Dec 2011 05:00:00 +0100 5543854 http://www.medworm.com/index.php?rid=5456652&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911017246%2Fabstract%3Frss%3Dyes Addendum Efficacy and safety of timothy grass allergy immunotherapy tablets in North American children and adolescents (Blaiss et al) (2011;127:64-71). 2011;128:436 (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5456652 Wed, 30 Nov 2011 23:54:13 +0100 5456652 http://www.medworm.com/index.php?rid=5456651&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911017234%2Fabstract%3Frss%3Dyes aan de Kerk DJ (see Kuijpers et al). 2011;128:1360-63 (Letter to the Editor) Abe S (see Kohyama et al). 2011;128:1117-20 (Letter to the Editor) (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5456651 Wed, 30 Nov 2011 23:54:13 +0100 5456651 http://www.medworm.com/index.php?rid=5456649&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911017209%2Fabstract%3Frss%3Dyes Credit can now be obtained, free for a limited time, by reading the review articles in this issue. Please note the instructions listed below: (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5456649 Wed, 30 Nov 2011 23:54:13 +0100 5456649 http://www.medworm.com/index.php?rid=5456623&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911016472%2Fabstract%3Frss%3Dyes In 1956, Alan Lyell reported, under the denomination of toxic epidermal necrolysis, the cases of 4 patients with acute necrosis and detachment of the superficial layers of the skin and mucous membrane. Over the years, it became obvious that Stevens-Johnson syndrome, which is also characterized by blisters affecting the skin and mucous membrane, was close to toxic epidermal necrolysis, and these 2 conditions are now considered severity variants of an identical process differing only in the extent of body surface involved. Therefore it seems preferable to use a single designation encompassing Stevens-Johnson syndrome, toxic epidermal necrolysis, and overlapping forms: epidermal necrolysis or exanthematic necrolysis (EN). (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5456623 Wed, 30 Nov 2011 23:54:12 +0100 5456623 http://www.medworm.com/index.php?rid=5456616&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911015727%2Fabstract%3Frss%3Dyes The pseudostratified ciliated epithelium of the airways provides a mucociliary barrier and participates in immune responses to protect the host against airborne threats. Airborne threats, such as microbes and environmental noxious stimuli, trigger the airway epithelial innate immune response aimed at defending the host against the threat and engaging the adaptive immune response. After the threat is controlled, the epithelium is able to repair itself. In this issue 2 articles show alterations in the airway epithelial mucociliary barrier in the setting of the innate antiviral immune response and chronic inflammation (adaptive immune response). (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5456616 Wed, 30 Nov 2011 23:54:12 +0100 5456616 http://www.medworm.com/index.php?rid=5456609&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911016502%2Fabstract%3Frss%3Dyes During recent years, eosinophilic esophagitis (EoE) has been diagnosed with an increasing frequency in westernized countries. Whether this reflects a true increase in incidence or merely an increased awareness of this disease is still debated. In this issue Hruz et al (p 1349) evaluated the epidemiology of EoE by prospectively conducting a population-based long-term study in a geographically and socioeconomically defined indicator area in Switzerland. The results revealed that significantly more EoE cases per 100,000 inhabitants were diagnosed between 2000 and 2009 than between 1989 and 1999. There was a marked increase in the number of EoE cases during the last 6 years (see Figure). This increase in EoE incidence was more pronounced than the increase in the number of upper endoscopies p... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5456609 Wed, 30 Nov 2011 23:54:12 +0100 5456609 http://www.medworm.com/index.php?rid=5456608&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911016563%2Fabstract%3Frss%3Dyes Asthma is the most common chronic respiratory disease, affecting up to 10% of adults and 30% of children in the Western world. Despite advances in asthma management, acute exacerbations continue to occur and impose considerable morbidity on patients and constitute a major burden on health care resources. Respiratory tract viruses have emerged as the most frequent triggers for exacerbations in both children and adults; however, the mechanisms underlying these remain poorly understood. More recently, it has become increasingly clear that interactions might exist between viruses and other triggers, increasing the likelihood of an exacerbation. In this article we begin with an overview of the health, economic, and social burden that exacerbations of asthma carry with them. This is followed by ... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5456608 Wed, 30 Nov 2011 23:54:12 +0100 5456608 http://www.medworm.com/index.php?rid=5456607&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS009167491101147X%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5456607 Wed, 30 Nov 2011 23:54:12 +0100 5456607 http://www.medworm.com/index.php?rid=5456605&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911014163%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5456605 Wed, 30 Nov 2011 23:54:12 +0100 5456605 http://www.medworm.com/index.php?rid=5456603&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911016666%2Fabstract%3Frss%3Dyes Asthma is associated with aberrant airway smooth muscle cell (ASMC) function and overexpression of TGF-β, which modulates ASMC proliferative and inflammatory function and induces oxidant release. Michaeloudes et al (Am J Respir Crit Care Med 2011;184:894-903) demonstrated that in ASMCs cultured from airways, TGF-β inhibits nuclear factor E2–related factor 2 (Nrf2), which regulates the expression of antioxidant genes in ASMCs. ASMCs from asthmatic patients had reduced antioxidant gene expression compared with those from healthy patients. Michaeloudes et al also demonstrated that ASMCs from patients with severe asthma were characterized by impaired Nrf2 signaling.Senior author, Kian Fan Chung, MD, DSc, from Imperial College, London, commented: “Oxidant-antioxidant imbalance appears to ... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5456603 Wed, 30 Nov 2011 23:54:12 +0100 5456603 http://www.medworm.com/index.php?rid=5456602&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911016927%2Fabstract%3Frss%3Dyes ▪ Online Teaching Slide Presentations (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5456602 Wed, 30 Nov 2011 23:54:12 +0100 5456602 http://www.medworm.com/index.php?rid=5456601&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911016915%2Fabstract%3Frss%3Dyes For this month's installment, we interviewed John Oppenheimer, MD, FAAAAI, chair of the AAAAI Interest Section Coordinating Committee (ISCC) and the Asthma Diagnosis and Treatment (ADT) Interest Section. Dr. Oppenheimer is currently the Director of Research at Pulmonary and Allergy Associates. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5456601 Wed, 30 Nov 2011 23:54:12 +0100 5456601 http://www.medworm.com/index.php?rid=5456600&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911016733%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5456600 Wed, 30 Nov 2011 23:54:12 +0100 5456600 http://www.medworm.com/index.php?rid=5456599&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS009167491101671X%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5456599 Wed, 30 Nov 2011 23:54:12 +0100 5456599 http://www.medworm.com/index.php?rid=5456598&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911016708%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5456598 Wed, 30 Nov 2011 23:54:12 +0100 5456598 http://www.medworm.com/index.php?rid=5456597&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911016691%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5456597 Wed, 30 Nov 2011 23:54:12 +0100 5456597 http://www.medworm.com/index.php?rid=5456596&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911016678%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5456596 Wed, 30 Nov 2011 23:54:12 +0100 5456596 http://www.medworm.com/index.php?rid=5543874&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911017325%2Fabstract%3Frss%3Dyes Conclusion: Because plant pollens, house dust, and some bacteria contain glycolipids that can directly activate NKT cells, these studies suggest that AHR and asthma can fully develop or be greatly enhanced through innate immune mechanisms involving IL-33, natural helper cells, and NKT cells. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543874 Mon, 28 Nov 2011 05:00:00 +0100 5543874 http://www.medworm.com/index.php?rid=5543857&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911017349%2Fabstract%3Frss%3Dyes Conclusions: This study provides an integrated view of the inflammatory networks that are upregulated during virus-induced asthma exacerbations in vivo. A series of innate signaling hubs were identified that could be novel therapeutic targets for asthma attacks. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543857 Thu, 24 Nov 2011 05:00:00 +0100 5543857 http://www.medworm.com/index.php?rid=5543895&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911017374%2Fabstract%3Frss%3Dyes To the Editor: We thank Dr Dreyfus for his comment on our report. We did monitor patients for thyroid function and did not find an increase in levels of free T3, free T4, or thyroid-stimulating hormone in patients treated with omalizumab. We also monitored patients for antibody levels and did not find a significant increase in anti–thyroid-stimulating hormone antibody levels in patients treated with omalizumab. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543895 Mon, 21 Nov 2011 05:00:00 +0100 5543895 http://www.medworm.com/index.php?rid=5543894&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911017362%2Fabstract%3Frss%3Dyes To the Editor: In a recent study entitled “Efficacy and safety of omalizumab in patients with chronic urticaria who exhibit IgE against thyroperoxidase,” the authors note that “[t]he number of patients with notable changes in laboratory values during the study was small.” No details of which laboratory studies were performed and whether they included monitoring of thyroid status are provided. This is surprising in view of the purported focus of the study on the safety of a medication in a population at risk for thyroid disease. Because there is at least 1 report in the literature of altered thyroid function temporally related to use of omalizumab in a patient with antithyroid antibodies and chronic urticaria that is not cited by the authors, some of the readers might appreciate a ... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543894 Mon, 21 Nov 2011 05:00:00 +0100 5543894 http://www.medworm.com/index.php?rid=5543877&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911017398%2Fabstract%3Frss%3Dyes Conclusion: Traffic-related air pollution exposure does not seem to increase the overall risk of sensitization to common inhalant and food allergens up to school age, but sensitization to certain allergens might be related to exposure during infancy. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543877 Mon, 21 Nov 2011 05:00:00 +0100 5543877 http://www.medworm.com/index.php?rid=5543872&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911016484%2Fabstract%3Frss%3Dyes Conclusion: These data suggest that the developmental changes in the thymus parallel the recognized changes in peripheral blood responses. There is also a developmental delay in the function of thymic regulatory cells in atopic compared with nonatopic children. These differences are fundamental to understanding early events that lead to immune dysregulation and might predispose to allergic disease. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543872 Mon, 21 Nov 2011 05:00:00 +0100 5543872 http://www.medworm.com/index.php?rid=5543860&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911016630%2Fabstract%3Frss%3Dyes Conclusion: Researchers should use objective rather than self-reported adherence data to identify clinical trial participants with low levels of adherence to study treatment. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543860 Mon, 21 Nov 2011 05:00:00 +0100 5543860 http://www.medworm.com/index.php?rid=5543849&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911016654%2Fabstract%3Frss%3Dyes Accumulation of anthropogenic gases, particularly CO2, is likely to have 2 fundamental effects on plant biology. The first is an indirect effect through Earth’s increasing average surface temperatures, with subsequent effects on other aspects of climate, such as rainfall and extreme weather events. The second is a direct effect caused by CO2-induced stimulation of photosynthesis and plant growth. Both effects are likely to alter a number of fundamental aspects of plant biology and human health, including aerobiology and allergic diseases, respectively. This review highlights the current and projected effect of increasing CO2 and climate change in the context of plants and allergen exposure, emphasizing direct effects on plant physiologic parameters (eg, pollen production) and indirect ef... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543849 Mon, 21 Nov 2011 05:00:00 +0100 5543849 http://www.medworm.com/index.php?rid=5646635&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911016186%2Fabstract%3Frss%3Dyes Conclusion: Our experience suggests that repeat STs are necessary for risk stratification in patients with a remote clinical history of HSR and an initial negative ST result because there is a significant rate of conversion to a positive ST result. ST converters have an increased risk of HSRs during subsequent carboplatin treatment. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646635 Fri, 18 Nov 2011 05:00:00 +0100 5646635 http://www.medworm.com/index.php?rid=5543893&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911016204%2Fabstract%3Frss%3Dyes To the Editor: Drs Rajalingham and Das raise important issues. It is certainly interesting to consider the role that obstructive sleep apnea (OSA) may have in asthma in individuals with morbid obesity. We have recently published that OSA is associated with symptoms of poor asthma control in obesity. However, we are not aware of literature suggesting that OSA causes airway hyperreactivity, though future studies of the role of OSA in asthma are certainly warranted. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543893 Fri, 18 Nov 2011 05:00:00 +0100 5543893 http://www.medworm.com/index.php?rid=5543892&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911016198%2Fabstract%3Frss%3Dyes To the Editor: We read with much interest the recently published article “Effects of obesity and bariatric surgery on airway hyperresponsiveness, asthma control, and inflammation” by Dixon et al. At this juncture, we wish to share a few scientific facts on the published article. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543892 Fri, 18 Nov 2011 05:00:00 +0100 5543892 http://www.medworm.com/index.php?rid=5646623&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911015739%2Fabstract%3Frss%3Dyes Conclusion: FLG null mutations modified the effects of smoking on the risk of asthma. This finding might have implications for risk stratification of the population. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646623 Thu, 17 Nov 2011 05:00:00 +0100 5646623 http://www.medworm.com/index.php?rid=5543870&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911016174%2Fabstract%3Frss%3Dyes Conclusion: In contrast to previous studies with BTK-deficient mice, cell lines, and cultured cells from patients with XLA suggesting impaired TLR-driven cytokine production, these data suggest that BTK inhibits TLR-induced cytokine production in primary human cells. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543870 Thu, 17 Nov 2011 05:00:00 +0100 5543870 http://www.medworm.com/index.php?rid=5646661&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911015697%2Fabstract%3Frss%3Dyes The possible effect of probiotics on tolerance acquisition in patients with cow's milk allergy (CMA) is a largely unexplored research area. The only previous study of the effect of probiotic strains (not including Lactobacillus GG [LGG]) on tolerance acquisition in children with CMA yielded negative results. Despite this finding and earlier conflicting results on probiotic use in patients with allergic disorders, we asked, given the well-documented link between LGG and the immune system, whether supplementation of an extensively hydrolyzed casein formula (EHCF) with LGG could affect tolerance acquisition to cow's milk protein (CMP). (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646661 Mon, 14 Nov 2011 05:00:00 +0100 5646661 http://www.medworm.com/index.php?rid=5646660&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911015673%2Fabstract%3Frss%3Dyes A patient presented to us with autosomal-dominant anhidrotic ectodermal dysplasia with immune deficiency syndrome (EDA-ID). By using a rapid flow cytometric screening system, we detected a novel mutation of the IKBA gene in the patient. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646660 Mon, 14 Nov 2011 05:00:00 +0100 5646660 http://www.medworm.com/index.php?rid=5646644&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911015612%2Fabstract%3Frss%3Dyes Conclusion: Allergic airway inflammation can be prevented by stimulation of human Treg cells by CD4. These results suggest a clinical potential of Treg-cell activation by high-affinity CD4 ligands in allergic diseases. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646644 Mon, 14 Nov 2011 05:00:00 +0100 5646644 http://www.medworm.com/index.php?rid=5646639&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911015703%2Fabstract%3Frss%3Dyes Conclusion: These observations provide the notions that (1) various telomere defects can lead to similar clinical features, (2) telomere dysfunction in cells from patients with DC/HH is not always associated with short telomeres, and (3) additional factors, likely involved in telomere protection rather than in length regulation, are responsible for a subset of DC/HH. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646639 Mon, 14 Nov 2011 05:00:00 +0100 5646639 http://www.medworm.com/index.php?rid=5543891&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS009167491101579X%2Fabstract%3Frss%3Dyes To the Editor: We thank Dr Korppi for his interest in our recent article. We agree that children with early human rhinovirus (HRV) wheezing illnesses demonstrate an obstructive pattern of lung function at ages 4 to 8 years compared with those who did not wheeze with HRV. Furthermore, this relationship persisted after a bronchodilator was administered, demonstrating that the obstructive pattern was not completely reversible. In the Childhood Origins of Asthma (COAST) cohort, we do not have any data on bronchial hyperresponsiveness at ages 4 to 8 years. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543891 Mon, 14 Nov 2011 05:00:00 +0100 5543891 http://www.medworm.com/index.php?rid=5543890&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911015788%2Fabstract%3Frss%3Dyes To the Editor: Guilbert et al published their interesting lung function results from the Childhood Origins of Asthma (COAST) study analyzed longitudinally at age 4 to 8 years in at-risk children in relation to wheezing during respiratory syncytial virus (RSV) or rhinovirus (RV) infection at age less than 3 years. Children with RV wheezing illness demonstrated significantly lower forced expiratory volume in 1 second (FEV1), FEV0.5, and forced expiratory flow at 25% to 75% of forced vital capacity (FVC) in both prebronchodilator and postbronchodilator spirometry and significantly lower FEV1% of predicted, FEV1/FVC, and FEV0.5/FVC in only prebronchodilator spirometry when compared with those who did not wheeze during RV infection. In the impulse oscillometry, the groups did not differ for r... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543890 Mon, 14 Nov 2011 05:00:00 +0100 5543890 http://www.medworm.com/index.php?rid=5543871&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS009167491101565X%2Fabstract%3Frss%3Dyes Conclusions: These findings identify nuocytes as a novel cell type in allergic lung inflammation and an innate source of IL-13 that can directly induce AHR in the absence of IL-13–producing CD4+ T cells. These data highlight nuocytes as an important new consideration in the development of future allergic asthma therapy. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543871 Mon, 14 Nov 2011 05:00:00 +0100 5543871 http://www.medworm.com/index.php?rid=5543869&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911015715%2Fabstract%3Frss%3Dyes Conclusion: For CGD, equivalent outcomes can be obtained with MRD or MUD stem cells, and HSCT should be considered an early treatment option. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543869 Mon, 14 Nov 2011 05:00:00 +0100 5543869 http://www.medworm.com/index.php?rid=5543868&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911015661%2Fabstract%3Frss%3Dyes Conclusion: Although foreign-born children and adolescents are at lower risk of food sensitization compared with those born in the US, among those born in the US, the children of immigrants are at the highest risk. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543868 Fri, 11 Nov 2011 05:00:00 +0100 5543868 http://www.medworm.com/index.php?rid=5646659&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911015636%2Fabstract%3Frss%3Dyes Asthma is a chronic inflammatory respiratory disease characterized by bronchial hyperresponsiveness, increased TH2 cytokine levels, and increased serum IgE levels. Atopic dermatitis or eczema is a chronic inflammatory skin disease characterized by epidermal barrier dysfunction and IgE-mediated sensitization. The only published genome-wide association study (GWAS) of atopic dermatitis identified rs7927894 on chromosome 11q13.5 between the chromosome 11 open reading frame 30 (C11orf30) and leucine-rich repeat containing 32 (LRRC32) genes. A replication study further confirmed the association of rs7927894 with childhood eczema. The same variant is also associated with Crohn disease, an inflammatory bowel disease. Increased total serum IgE levels are common in both patients with asthma and th... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646659 Thu, 10 Nov 2011 05:00:00 +0100 5646659 http://www.medworm.com/index.php?rid=5646658&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911015648%2Fabstract%3Frss%3Dyes Asthma is a chronic inflammatory disease associated with genetic and environmental factors. Although the 12q13-24 chromosome region had previously shown linkage to asthma, the IL-1 receptor–associated kinase 3 gene (IRAK3) has recently emerged as a susceptibility candidate for asthma as a result of positional cloning of persistent asthma with age of onset less than 13 years in Italian samples. IRAK3 encodes a protein that negatively regulates Toll-like receptor signaling pathways involved in innate host defense and in the control of adaptive immune responses. However, single nucleotide polymorphisms (SNPs) near IRAK3 have not reached the stringent significance thresholds in any of the genome-wide association studies (GWASs) performed in asthmatic patients. Here we aimed to replicate the ... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646658 Thu, 10 Nov 2011 05:00:00 +0100 5646658 http://www.medworm.com/index.php?rid=5646628&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911015594%2Fabstract%3Frss%3Dyes Conclusions: Fewer preschool-age children with allergic rhinitis undergo remission than do those with nonallergic rhinitis. Sensitization to inhaled allergens at an early age (4 years) precedes the development of allergic rhinitis, whereas symptoms of rhinitis do not. Oral allergy syndrome is common among 8-year-olds with allergic rhinitis. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646628 Mon, 07 Nov 2011 05:00:00 +0100 5646628 http://www.medworm.com/index.php?rid=5543876&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911015600%2Fabstract%3Frss%3Dyes Conclusion: Promoter variants in NOS2 and short-term PM2.5 exposure affect iNOS methylation. This is one of the first studies showing contributions of genetic and epigenetic variations in air pollution–mediated phenotype expression. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543876 Mon, 07 Nov 2011 05:00:00 +0100 5543876 http://www.medworm.com/index.php?rid=5646643&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911015028%2Fabstract%3Frss%3Dyes Conclusion: Functional allergen-specific Treg cells are identified both in lingual and in palatine tonsils. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646643 Fri, 04 Nov 2011 04:00:00 +0100 5646643 http://www.medworm.com/index.php?rid=5646622&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911015570%2Fabstract%3Frss%3Dyes Conclusion: The findings highlight an important gene-environment interaction that elucidates the role of vitamin D and CD8+ and natural killer T cells in asthma exacerbation in a genome-wide gene-environment interaction study that has been replicated in an independent population. The results suggest the potential importance of maintaining adequate vitamin D levels in subsets of high-risk asthmatic patients. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646622 Thu, 03 Nov 2011 04:00:00 +0100 5646622 http://www.medworm.com/index.php?rid=5382930&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911014928%2Fabstract%3Frss%3Dyes Credit can now be obtained, free for a limited time, by reading the review articles in this issue. Please note the instructions listed below: (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5382930 Tue, 01 Nov 2011 04:00:00 +0100 5382930 http://www.medworm.com/index.php?rid=5382904&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911014977%2Fabstract%3Frss%3Dyes The concept of eosinophil-associated tissue remodeling and fibrosis has its roots in the hypereosinophilic syndrome and asthmatic airways. In asthmatic patients TH2-associated eotaxins and interleukins activate eosinophils to release granule products and growth factors that propagate inflammation and cause tissue damage. Continual and recurrent dysregulated repair leads to tissue remodeling with subsequent fibrosis and end-organ dysfunction. The reversibility, natural history, and clinical consequences of eosinophil-associated remodeling have been largely debated, especially in human disease, in which the paucity of tissue for repeated analysis has been a rate-limiting factor in our understanding. The availability of adequate surrogate markers in patients with disorders such as asthma has ... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5382904 Tue, 01 Nov 2011 04:00:00 +0100 5382904 http://www.medworm.com/index.php?rid=5382898&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911013960%2Fabstract%3Frss%3Dyes Conclusions: This relatively large meta-analysis of GWASs identified few loci associated with AR and grass sensitization. No birth order interaction was identified in the current analyses. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5382898 Tue, 01 Nov 2011 04:00:00 +0100 5382898 http://www.medworm.com/index.php?rid=5382890&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911014941%2Fabstract%3Frss%3Dyes As reported in this issue, van der Zee et al (p 1031) used the eliciting dose as a measure for clinical sensitivity. They studied whether risk factors for severe food-induced allergic reactions in daily life could influence the eliciting dose in double-blind, placebo-controlled food challenges in children with peanut allergy. For children more than 10 years of age, a specific IgE level greater than the lowest tertile (≥5.6 kU/L) and the absence of atopic dermatitis were associated with reactions to lower doses (see Figure). No significant associations with the eliciting dose were found for sex, presence of asthma and rhinitis, and severity of food reactions by history. The authors conclude that using the eliciting dose as a measure for clinical sensitivity, greater clinical sensitivity ... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5382890 Tue, 01 Nov 2011 04:00:00 +0100 5382890 http://www.medworm.com/index.php?rid=5382889&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911014916%2Fabstract%3Frss%3Dyes Recent studies of the natural history of asthma have shifted attention toward viral respiratory tract illness in early life as a major risk factor associated with the development of the most persistent forms of the disease. Although early aeroallergen sensitization is strongly associated with chronic asthma, several trials in which single-aeroallergen exposure in pregnancy and early childhood was successfully accomplished and compared with sham avoidance have failed to show any decrease in asthma incidence. New evidence suggests that complex interactions occur between viral infection and aeroallergen sensitization in genetically susceptible subjects that trigger the immune responses and airway changes that are characteristic of persistent asthma. The finding that exposure to bacterial prod... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5382889 Tue, 01 Nov 2011 04:00:00 +0100 5382889 http://www.medworm.com/index.php?rid=5382887&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911011468%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5382887 Tue, 01 Nov 2011 04:00:00 +0100 5382887 http://www.medworm.com/index.php?rid=5382885&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911011456%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5382885 Tue, 01 Nov 2011 04:00:00 +0100 5382885 http://www.medworm.com/index.php?rid=5382883&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS009167491101493X%2Fabstract%3Frss%3Dyes Previously described heterozygous mutations in signal transducer and activator of transcription 1 (STAT1) were loss-of-function mutations and associated with autosomal dominant predisposition to mycobacterial disease caused by impaired STAT1-dependent IFN-γ responses. Surprisingly, Liu et al (J Exp Med 2011;208:1635-48) published heterozygous STAT1 mutations in 47 patients from 20 families with autosomal dominant chronic mucocutaneous candidiasis. They demonstrated that the missense mutations, all located in the STAT1 coiled-coil region, were gain-of-function mutations because they increased STAT1 phosphorylation. The mechanism involves impaired nuclear dephosphorylation of activated STAT1. As a result, cells heterozygous for gain-of-function STAT1 mutations displayed enhanced STAT1-depen... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5382883 Tue, 01 Nov 2011 04:00:00 +0100 5382883 http://www.medworm.com/index.php?rid=5382882&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911015302%2Fabstract%3Frss%3Dyes ▪ Online Teaching Slide Presentations (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5382882 Tue, 01 Nov 2011 04:00:00 +0100 5382882 http://www.medworm.com/index.php?rid=5382881&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911015296%2Fabstract%3Frss%3Dyes Don't Wait, Register Today As a member benefit, registration for the 2012 Annual Meeting is open at www.annualmeeting.aaaai.org only to AAAAI members until November 9. Be sure to take advantage of this benefit before announcements are made for general registration. Sessions fill up quickly, so register today to get into the ones you want. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5382881 Tue, 01 Nov 2011 04:00:00 +0100 5382881 http://www.medworm.com/index.php?rid=5382880&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911015107%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5382880 Tue, 01 Nov 2011 04:00:00 +0100 5382880 http://www.medworm.com/index.php?rid=5382879&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911015089%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5382879 Tue, 01 Nov 2011 04:00:00 +0100 5382879 http://www.medworm.com/index.php?rid=5382878&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911015077%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5382878 Tue, 01 Nov 2011 04:00:00 +0100 5382878 http://www.medworm.com/index.php?rid=5382877&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911015065%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5382877 Tue, 01 Nov 2011 04:00:00 +0100 5382877 http://www.medworm.com/index.php?rid=5382876&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911015041%2Fabstract%3Frss%3Dyes (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5382876 Tue, 01 Nov 2011 04:00:00 +0100 5382876 http://www.medworm.com/index.php?rid=5646657&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911015569%2Fabstract%3Frss%3Dyes Although allergen immunotherapy (IT) is generally safe, it carries a risk of systemic reactions (SRs); predicting which patients will have SRs has proven to be difficult. Self-injectable epinephrine (SIE) in the form of a device was first introduced in 1980 and allows physicians to give a potentially life-saving treatment to those patients at risk of having an SR. However, there is no current consensus regarding the use of SIE prescriptions for patients on IT and the decision to prescribe SIE falls on the physician administering IT. Our objective was to investigate current practices among allergists on SIE-prescribing habits for IT recipients. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646657 Mon, 31 Oct 2011 04:00:00 +0100 5646657 http://www.medworm.com/index.php?rid=5646656&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911015582%2Fabstract%3Frss%3Dyes Asthma affects all age groups and presents itself as a spectrum of severity and symptoms. Reactive oxygen species (ROS) play a pivotal role in asthma pathogenesis. Exhaled levels of mediators associated with ROS positively correlate with asthma severity. Autophagy, the process of cellular waste disposal through lysosome-dependent pathways, is induced by ROS to remove oxidized proteins or organelles to minimize tissue damage. Although autophagy is augmented in the lungs of patients with chronic obstructive pulmonary disease compared with healthy control subjects, evidence for autophagy in asthmatic patients, particularly those with moderate-to-severe asthma, has not been reported. We hypothesize that autophagy is associated with asthma pathogenesis and sought to detect its presence using bo... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646656 Mon, 31 Oct 2011 04:00:00 +0100 5646656 http://www.medworm.com/index.php?rid=5646655&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS009167491101503X%2Fabstract%3Frss%3Dyes We have shown that IFN-γ production at 3 and 9 months is inversely associated with frequent wheeze in the first year of life and with wheeze up to age 13 years, respectively. If early-life IFN-γ production predicts later wheeze, it is important to consider whether there are prenatal predictors of IFN-γ and, if so, whether these factors might actually be the driving force for the relation with wheeze. For example, if parental smoking is associated with early IFN-γ production, an observed relation between IFN-γ production and wheeze could be attributable to passive smoke exposure. In addition, there appear to be sex-specific differences in both immune responses and prevalence of wheeze, suggesting that potential modifications of the IFN-γ–wheeze relation by sex should be investigated... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646655 Mon, 31 Oct 2011 04:00:00 +0100 5646655 http://www.medworm.com/index.php?rid=5646654&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911014990%2Fabstract%3Frss%3Dyes We report the results of a study whose objectives were to determine the frequency with which reports of DH in a tertiary university hospital bring about both changes in drug selection and increased costs and also to assess the validity of the initial DH diagnosis. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646654 Mon, 31 Oct 2011 04:00:00 +0100 5646654 http://www.medworm.com/index.php?rid=5646653&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911014953%2Fabstract%3Frss%3Dyes The recently published National Institute of Allergy and Infectious Diseases–sponsored “Guidelines for the diagnosis and management of food allergy in the United States” and the “Work group report” both state that oral food challenge (OFC) is a critical procedure for the evaluation of food allergy. Fleischer et al reported that OFCs were crucial in identifying children who were otherwise following unnecessary dietary restrictions based on the results of in vitro testing. A subgroup of the Adverse Reactions to Foods Committee of the American Academy of Allergy, Asthma & Immunology (AAAAI) conceived and designed a survey to collect data about allergists' use of this important diagnostic procedure. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646653 Mon, 31 Oct 2011 04:00:00 +0100 5646653 http://www.medworm.com/index.php?rid=5646621&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911014862%2Fabstract%3Frss%3Dyes Conclusion: The findings provide support for the idea that the hygiene hypothesis is operating in an urban Latin American context, but its expression is thus far restricted to the atopic status of patients and not the perceived asthma symptoms. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646621 Mon, 31 Oct 2011 04:00:00 +0100 5646621 http://www.medworm.com/index.php?rid=5543885&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911014102%2Fabstract%3Frss%3Dyes To the Editor: We agree with Koletzko et al that our study, like all studies, has some limitations. However, these limitations are by no means as severe as they suggest. We address their criticisms of the scientific merit of the study here, while dealing with this group's other statements, including the delay in publication, within this article's Online Repository at www.jacionline.org. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543885 Mon, 31 Oct 2011 04:00:00 +0100 5543885 http://www.medworm.com/index.php?rid=5543884&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911014096%2Fabstract%3Frss%3Dyes To the Editor: Lowe et al report on a single-blind randomized trial on the effects of soy or partially hydrolyzed whey formula (pHWF) compared with cow's milk protein formula (CMF) on allergy risk in 620 infants with a family history of allergy and found no group difference at age 2 years for cumulative incidence of any allergic manifestation (CMF, 48.7%; soy, 54.5%; pHWF, 53.4%), eczema, or food allergy. In contrast to the authors, we conclude that this study should not lead to changing current recommendations on allergy prevention because of its severe methodological limitations, including addition of a third intervention arm after study start, high randomization losses, lack of double blinding and information on allocation concealment, changing definitions of outcome parameters compar... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543884 Mon, 31 Oct 2011 04:00:00 +0100 5543884 http://www.medworm.com/index.php?rid=5543875&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911014965%2Fabstract%3Frss%3Dyes Conclusion: We identified an association between aeroallergens and hospitalizations for asthma, which was enhanced on days of higher air pollution. Minimizing exposure to air pollution might reduce allergic exacerbations of asthma. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543875 Mon, 31 Oct 2011 04:00:00 +0100 5543875 http://www.medworm.com/index.php?rid=5456604&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911014084%2Fabstract%3Frss%3Dyes In this review we celebrate a century of progress since the initial description of the physiologic and pathologic roles of histamine and 70 years of progress since the introduction of H1-antihistamines for clinical use. We discuss histamine and clinically relevant information about the molecular mechanisms of action of H1-antihistamines as inverse agonists (not antagonists or blockers) with immunoregulatory effects. Unlike first (old)–generation H1-antihistamines introduced from 1942 to the mid-1980s, most of the second (new)–generation H1-antihistamines introduced subsequently have been investigated extensively with regard to clinical pharmacology, efficacy, and safety; moreover, they are relatively free from adverse effects and not causally linked with fatalities after overdose. Impo... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5456604 Mon, 31 Oct 2011 04:00:00 +0100 5456604 http://www.medworm.com/index.php?rid=5646651&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911014886%2Fabstract%3Frss%3Dyes Heterozygous mutations in the transcription factor signal transducer and activator of transcription 3 (STAT3) have been identified in patients with autosomal dominant hyper-IgE syndrome (HIES). The clinical phenotype of STAT3-HIES is characterized by Staphylococcus aureus–induced skin abscesses, pneumonia with pneumatocele formation, mucocutaneous candidiasis, eczema, and skeletal and connective tissue abnormalities, suggesting a crucial role for STAT3 signaling in both innate and adaptive immunity. To address the effect of decreased STAT3 signaling on the B-cell compartment, we enrolled 25 patients with STAT3-HIES (age, 2.5-51 years) from 20 unrelated families (see in this article’s Online Repository at www.jacionline.org) and 30 healthy subjects (age, 18-72 years) and determined anti... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646651 Fri, 28 Oct 2011 04:00:00 +0100 5646651 http://www.medworm.com/index.php?rid=5456618&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911014850%2Fabstract%3Frss%3Dyes Conclusion: Early food sensitization and the presence of an FLG mutation in infants with early eczema increase the risk for later asthma, but the combination of the 2 factors does not represent a clinically useful approach to reliably identify children at risk. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5456618 Fri, 28 Oct 2011 04:00:00 +0100 5456618 http://www.medworm.com/index.php?rid=5646652&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911014874%2Fabstract%3Frss%3Dyes Nitrile gloves are the alternative for health professionals sensitized to latex in case of biological risk or managing of chemical substances with irritating or toxic properties. There are very few reactions published in the literature with the use of these gloves. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646652 Mon, 24 Oct 2011 04:00:00 +0100 5646652 http://www.medworm.com/index.php?rid=5646650&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911014904%2Fabstract%3Frss%3Dyes The “F-ring” urinary prostaglandin D2 (PGD2) metabolites—9α,11β-prostaglandin F2 (9α,11β-PGF2), 2,3-dinor-9α,11β-prostaglandin F2 (2,3-dinor-9α,11β-PGF2), and 9α,11β-dihydroxy-15-oxo-2,3,18,19-tetranorprost-5-ene-1,20-dioic acid—are useful biomarkers of mast cell activation. In an original article recently published in this Journal, we employed gas chromatography-mass spectrometry-negative ion chemical ionization for the quantification of 2,3-dinor-9α,11β-PGF2 in urine from subjects with anaphylaxis or with aspirin-intolerant asthma (AIA). When assessed by changes in the 2,3-dinor-9α,11β-PGF2 concentration, PGD2 generation was more obviously evident during the acute exacerbation of anaphylaxis or AIA. We thus provided further evidence that AIA reactions are triggere... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646650 Mon, 24 Oct 2011 04:00:00 +0100 5646650 http://www.medworm.com/index.php?rid=5646649&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911014837%2Fabstract%3Frss%3Dyes Although a specific substance is identified as the cause for the onset of occupational asthma (OA), the removal of this substance does not induce a remission of the disease in the vast majority of subjects. The assessment of impairment/disability of OA after removal from exposure is currently performed in the province of Quebec by performing spirometry and identifying airflow limitation through airway hyperresponsiveness (AHR) to methacholine, and assessing the need for asthma medication 2 years after the initial diagnosis of OA. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646649 Mon, 24 Oct 2011 04:00:00 +0100 5646649 http://www.medworm.com/index.php?rid=5543867&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911014898%2Fabstract%3Frss%3Dyes Conclusions: Food is the main anaphylaxis trigger in the urban PED, although the International Classification of Diseases-ninth revision code for anaphylaxis is underused. Treatment with 2 doses of epinephrine is associated with a higher risk of hospitalization; epinephrine treatment before arrival to the PED is associated with a decreased risk. Children with Medicaid are less likely to receive epinephrine before arrival in the PED. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543867 Mon, 24 Oct 2011 04:00:00 +0100 5543867 http://www.medworm.com/index.php?rid=5456645&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911013200%2Fabstract%3Frss%3Dyes To the Editor: Newborn screening for severe T-cell immunodeficiency disorders has been recommended in the United States by using PCR quantitation and the measurement of T-cell receptor excision circles (TRECs) as a validated assay. TRECs are small episomal pieces of DNA that are formed during the rearrangement of T-cell receptor genes of thymocytes undergoing differentiation in the thymus. One particular TREC is the δRec-ψJα TREC produced by approximately 70% of all T cells that express the α/β T-cell receptor. Quantitation of these TRECs in peripheral blood T cells is a measure of recent emigrants from the thymus of naive T cells, a surrogate marker for thymopoiesis. In newborn screening, the TREC assay is performed on DNA isolated from the Guthrie card blood spots. Decreased TRECs ... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5456645 Mon, 24 Oct 2011 04:00:00 +0100 5456645 http://www.medworm.com/index.php?rid=5456633&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911014849%2Fabstract%3Frss%3Dyes To the Editor: Eosinophilic esophagitis (EoE) is an emerging, chronic, IL-5–driven inflammatory disorder of the esophagus, clinically characterized by symptoms related to esophageal dysfunction and histologically by eosinophil-predominant inflammation. Several reports suggest that EoE has been diagnosed with a dramatically increasing frequency over the last years in Westernized countries. Whether this reflects a true increase in incidence or just an increased awareness of this disease is currently unknown. So far, the vast majority of studies addressing this pivotal epidemiological question rely on retrospective analyses of pathology or endoscopy databases. Here, we evaluated the epidemiology of EoE by prospectively conducting a population-based long-term study in a geographically and s... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5456633 Mon, 24 Oct 2011 04:00:00 +0100 5456633 http://www.medworm.com/index.php?rid=5456611&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911014813%2Fabstract%3Frss%3Dyes Conclusions: ICS adherence varies in the time period leading up to and after an asthma exacerbation, and nonadherence likely contributes to a large number of these exacerbations. High levels of adherence are likely required to prevent these events. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5456611 Mon, 24 Oct 2011 04:00:00 +0100 5456611 http://www.medworm.com/index.php?rid=5646630&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911014527%2Fabstract%3Frss%3Dyes Conclusion: In this registry-based observational study, receiving SCIT compared with CAT was associated with lower risk of autoimmune disease and AMI, as well as decreased all-cause mortality. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5646630 Mon, 17 Oct 2011 04:00:00 +0100 5646630 http://www.medworm.com/index.php?rid=5543880&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911014059%2Fabstract%3Frss%3Dyes To the Editor: Asthma is one of the most common health conditions that might complicate pregnancy, and poorly controlled asthma poses substantial risks to both maternal and fetal health, including increased risk of congenital anomalies. Because inadequate asthma control poses a greater risk to fetal health than do asthma medications, current asthma and obstetric guidelines recommend using effective drug therapy to control asthma. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543880 Mon, 17 Oct 2011 04:00:00 +0100 5543880 http://www.medworm.com/index.php?rid=5543865&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911014539%2Fabstract%3Frss%3Dyes Conclusions: CRH-mediated suppression of IL-10 secretion from Treg cells might explain stress-related exacerbations in patients with AD. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543865 Mon, 17 Oct 2011 04:00:00 +0100 5543865 http://www.medworm.com/index.php?rid=5456646&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911014552%2Fabstract%3Frss%3Dyes Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a primary immunodeficiency with severe autoimmunity caused by mutations in the forkhead box protein 3 gene (FOXP3). FOXP3 encodes a transcription factor critical for the function of naturally occurring regulatory T (Treg) cells, which are devoted to tolerance maintenance. Impairment of Treg cells is the main pathogenic mechanism underlying IPEX syndrome. However, increasing evidence suggests that FOXP3 might also impinge effector T (Teff) cells. Indeed, FOXP3 inhibits TH17 cell differentiation and IL-17 production, and we reasoned that in patients with IPEX syndrome, in addition to loss of suppressive function, augmented TH17 responses might be responsible for autoimmunity. (Source: Journal of Allergy and Cl... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5456646 Mon, 17 Oct 2011 04:00:00 +0100 5456646 http://www.medworm.com/index.php?rid=5543882&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911014114%2Fabstract%3Frss%3Dyes To the Editor: Several birth cohort studies aimed at preventing the development of asthma by reducing the amount of exposure to inhalant allergens found no effects or even opposite effects on atopy development. The Dutch Prevention and Incidence of Asthma and Mite Allergy (PIAMA) study investigated whether the use of mite allergen–impermeable mattress covers (IMCs) reduced the risk of asthma and allergy in high-risk children. No effect was found, despite lower allergen levels on the children's mattresses. The Dutch Prevention of Asthma in Children (PREVASC) study and Canadian Childhood Asthma Primary Prevention Study (CAPPS) assessed the effectiveness of a multifaceted intervention program for primary prevention of asthma in high-risk children, including the use of mattress covers. A m... Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543882 Fri, 14 Oct 2011 04:00:00 +0100 5543882 http://www.medworm.com/index.php?rid=5543862&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911014047%2Fabstract%3Frss%3Dyes Conclusion: Epicutaneous immunotherapy is safe and efficacious in a dose-dependent manner after 6 patches only. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543862 Fri, 14 Oct 2011 04:00:00 +0100 5543862 http://www.medworm.com/index.php?rid=5456613&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911014072%2Fabstract%3Frss%3Dyes Conclusions: Autoantibodies, particularly those against nuclear antigens, are present at locally increased levels in nasal polyps. The presence of autoantibodies suggests that the microenvironment of a nasal polyp promotes the expansion of self-reactive B-cell clones. Although the pathogenicity of these antibodies remains to be elucidated, the presence of increased anti-dsDNA antibody levels is associated with a clinically more aggressive form of CRS with nasal polyps requiring repeated surgery. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5456613 Fri, 14 Oct 2011 04:00:00 +0100 5456613 http://www.medworm.com/index.php?rid=5543881&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911014035%2Fabstract%3Frss%3Dyes To the Editor: Wood is a natural material that is able to trigger rhinitis and asthma in exposed subjects in occupational settings. This has been described with both soft and hard woods. Involvement of both low- and high-molecular-weight allergens has been reported, and the relevance of these is related with the wood type. There are cases where protein may be the responsible allergen. Cross-reactivity between obeche and ramin woods and between obeche and latex has been shown. However, to the best of our knowledge, this is the first report of a multiple IgE-mediated sensitization to different woods that caused occupational respiratory symptoms in the same worker. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543881 Thu, 13 Oct 2011 04:00:00 +0100 5543881 http://www.medworm.com/index.php?rid=5456615&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911014011%2Fabstract%3Frss%3Dyes Conclusions: PolyI:C has a powerful and previously unsuspected disruptive effect on the airway epithelial barrier. PolyI:C-dependent barrier disruption is mediated by disassembly of epithelial apical junctions, which is dependent on PKD signaling. These findings suggest a new mechanism potentially underlying the associations between viral respiratory tract infections, airway inflammation, and allergen sensitization. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5456615 Thu, 13 Oct 2011 04:00:00 +0100 5456615 http://www.medworm.com/index.php?rid=5543889&cid=s_33857_3_f&fid=33857&url=http%3A%2F%2Fwww.jacionline.org%2Farticle%2FPIIS0091674911014151%2Fabstract%3Frss%3Dyes To the Editor: We thank Zhang et al for their interest in our study. These authors have raised an important issue about vascular endothelial (VE)–cadherin phosphorylation, endocytosis, and ectodomain shedding that warrants clarification. (Source: Journal of Allergy and Clinical Immunology) Journal of Allergy and Clinical Immunology journals http://www.medworm.com/rss/comments.php?id=5543889 Mon, 10 Oct 2011 04:00:00 +0100 5543889