MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Journal of Biomedical Discovery and Collaboration' source. Sat, 10 Oct 2009 19:32:51 +0100 http://www.medworm.com/index.php?rid=2181998&cid=s_34074_61_f&fid=34074&url=http%3A%2F%2Fwww.j-biomed-discovery.com%2Fcontent%2F4%2F1%2F2 Conclusions: As the next great frontier in bioinformatics usability, tool designs for exploratory systems biology analysis need to move beyond the successes already achieved in supporting formulaic query and analysis tasks and now reduce current mismatches with several of scientists' higher order analytical practices. The implications of results for tool designs are discussed. (Source: Journal of Biomedical Discovery and Collaboration) Journal of Biomedical Discovery and Collaboration journals http://www.medworm.com/rss/comments.php?id=2181998 Fri, 13 Feb 2009 05:00:00 +0100 2181998 http://www.medworm.com/index.php?rid=1268202&cid=s_34074_61_f&fid=34074&url=http%3A%2F%2Fwww.j-biomed-discovery.com%2Fcontent%2F3%2F1%2F3 Conclusion: This sample of key UK scientists and grant providers acknowledge the importance of basic blue skies research. Yet the current evaluation process often requires that scientists predict their likely findings and estimate short-term impact, which does not permit freedom of research direction. There is a vital need for prominent scientists and for universities to help the media, the public, and policy makers to understand the importance of innovative thought along with the need for scientists to have the freedom to challenge accepted thinking. Encouraging an avenue for blue skies research could have immense influence over future scientific discoveries. (Source: Journal of Biomedical Discovery and Collaboration) Journal of Biomedical Discovery and Collaboration journals http://www.medworm.com/rss/comments.php?id=1268202 Fri, 29 Feb 2008 05:00:00 +0100 1268202 http://www.medworm.com/index.php?rid=1187027&cid=s_34074_61_f&fid=34074&url=http%3A%2F%2Fwww.j-biomed-discovery.com%2Fcontent%2F3%2F1%2F1 Conclusions: The software presented in this paper demonstrates the potential for novel discovery resulting from the structured evaluation of biomedical language processing systems, as well as the usefulness of such an evaluation framework for promoting collaboration between developers of biomedical language processing technologies. The code base is available as part of the BioNLP UIMA Component Repository on SourceForge.net. (Source: Journal of Biomedical Discovery and Collaboration) Journal of Biomedical Discovery and Collaboration journals http://www.medworm.com/rss/comments.php?id=1187027 Tue, 29 Jan 2008 05:00:00 +0100 1187027 http://www.medworm.com/index.php?rid=925051&cid=s_34074_61_f&fid=34074&url=http%3A%2F%2Fwww.j-biomed-discovery.com%2Fcontent%2F2%2F1%2F5 Conclusions: More systematic application of the idea of similarity-based categorization might eliminate the assumption that biological characteristics can only contribute to narrow categorization of humans. It also raises possibilities for refining data-driven exploration efforts. (Source: Journal of Biomedical Discovery and Collaboration) Journal of Biomedical Discovery and Collaboration journals http://www.medworm.com/rss/comments.php?id=925051 Wed, 03 Oct 2007 04:00:00 +0100 925051 http://www.medworm.com/index.php?rid=869293&cid=s_34074_61_f&fid=34074&url=http%3A%2F%2Fwww.j-biomed-discovery.com%2Fcontent%2F2%2F1%2F4 Conclusions: We conclude that refactoring of publicly available corpora is a technically and economically feasible method for increasing the usage of data already available for evaluating biomedical language processing systems. (Source: Journal of Biomedical Discovery and Collaboration) Journal of Biomedical Discovery and Collaboration journals http://www.medworm.com/rss/comments.php?id=869293 Thu, 13 Sep 2007 04:00:00 +0100 869293 http://www.medworm.com/index.php?rid=734778&cid=s_34074_61_f&fid=34074&url=http%3A%2F%2Fwww.j-biomed-discovery.com%2Fcontent%2F2%2F1%2F3 Nanotechnology research has lately been of intense interest because of its perceived potential for many diverse fields of science. Nanotechnology's tools have found application in diverse fields, from biology to device physics. By the 1990s, there was a concerted effort in the United States to develop a national initiative to promote such research. The success of this effort led to a significant influx of resources and interest in nanotechnology and nanobiotechnology and to the establishment of centralized research programs and facilities. Further government initiatives (at federal, state, and local levels) have firmly cemented these disciplines as 'big science,' with efforts increasingly concentrated at select laboratories and centers. In many respects, these trends mirror certain changes... Journal of Biomedical Discovery and Collaboration journals http://www.medworm.com/rss/comments.php?id=734778 Sat, 14 Jul 2007 04:00:00 +0100 734778 http://www.medworm.com/index.php?rid=588835&cid=s_34074_61_f&fid=34074&url=http%3A%2F%2Fwww.j-biomed-discovery.com%2Fcontent%2F2%2F1%2F2 Conclusions: The result shows the added value of a multidisciplinary approach combined with information retrieval in hypothesis discovery in biomedical research. The new hypothesis, which was derived in silico, provides a framework for further mechanistic studies into the underlying molecular mechanisms of CRPS and requires evaluation in clinical and epidemiological studies. (Source: Journal of Biomedical Discovery and Collaboration) Journal of Biomedical Discovery and Collaboration journals http://www.medworm.com/rss/comments.php?id=588835 Fri, 04 May 2007 04:00:00 +0100 588835 http://www.medworm.com/index.php?rid=411331&cid=s_34074_61_f&fid=34074&url=http%3A%2F%2Fwww.j-biomed-discovery.com%2Fcontent%2F2%2F1%2F1 Data management and integration are complicated and ongoing problems that will require commitment of resources and expertise from the various biological science communities. Primary components of successful cross-scale integration are smooth information management and migration from one context to another. We call for a broadening of the definition of bioinformatics and bioinformatics training to span biological disciplines and biological scales. Training programs are needed that educate a new kind of informatics professional, Biological Information Specialists, to work in collaboration with various discipline-specific research personnel. Biological Information Specialists are an extension of the informationist movement that began within Library and Information Science (LIS) over 30 years ... Journal of Biomedical Discovery and Collaboration journals http://www.medworm.com/rss/comments.php?id=411331 Mon, 12 Feb 2007 07:00:00 +0100 411331 http://www.medworm.com/index.php?rid=361473&cid=s_34074_61_f&fid=34074&url=http%3A%2F%2Fwww.j-biomed-discovery.com%2Fcontent%2F1%2F1%2F16 For a neurobiologist, the core of human nature is the human cerebral cortex, especially the prefrontal areas, and the question "what makes us human?" translates into studies of the development and evolution of the human cerebral cortex, a clear oversimplification. In this comment, after pointing out this oversimplification, I would like to show that it is impossible to understand our cerebral cortex if we focus too narrowly on it. Like other organs, our cortex evolved from that in stem amniotes, and it still bears marks of that ancestry. More comparative studies of brain development are clearly needed if we want to understand our brain in its historical context. Similarly, comparative genomics is a superb tool to help us understand evolution, but again, studies should not be limited to mam... Journal of Biomedical Discovery and Collaboration journals http://www.medworm.com/rss/comments.php?id=361473 Wed, 29 Nov 2006 07:00:00 +0100 361473 http://www.medworm.com/index.php?rid=361472&cid=s_34074_61_f&fid=34074&url=http%3A%2F%2Fwww.j-biomed-discovery.com%2Fcontent%2F1%2F1%2F13 What makes man human is his brain. This brain is obviously different from those of nonhuman primates. It is larger, shows hemispheric dominance and specialization, and is cytoarchitecturally somewhat more generalized. But are these the essential characteristics that determine the humanness of man? This paper cannot give an answer to this question for the answer is not known. But the problem can be stated more specifically, alternatives spelled out on the basis of available research results, and directions given for further inquiry. My theme will be that the human brain is so constructed that man, and only man, feels the thrust to make meaningful all his experiences and encounters. Development of this theme demands an analysis of the brain mechanisms that make meaning–and an attempt to de... Journal of Biomedical Discovery and Collaboration journals http://www.medworm.com/rss/comments.php?id=361472 Wed, 29 Nov 2006 07:00:00 +0100 361472 http://www.medworm.com/index.php?rid=361471&cid=s_34074_61_f&fid=34074&url=http%3A%2F%2Fwww.j-biomed-discovery.com%2Fcontent%2F1%2F1%2F14 Scientific and popular lore have promulgated a connection between emotion and the limbic forebrain. However, there are a variety of structures that are considered limbic, and disagreement as to what is meant by "emotion". This essay traces the initial studies upon which the connection between emotion and the limbic forebrain was based and how subsequent experimental evidence led to confusion both with regard to brain systems and to the behaviors examined. In the process of sorting out the bases of the confusion the following rough outlines are sketched: 1) Motivation and emotion need to be distinguished. 2) Motivation and emotion are processed by the basal ganglia; motivation by the striatum and related structures, emotion by limbic basal ganglia: the amygdala and related structures. 3) Th... Journal of Biomedical Discovery and Collaboration journals http://www.medworm.com/rss/comments.php?id=361471 Wed, 29 Nov 2006 07:00:00 +0100 361471 http://www.medworm.com/index.php?rid=361470&cid=s_34074_61_f&fid=34074&url=http%3A%2F%2Fwww.j-biomed-discovery.com%2Fcontent%2F1%2F1%2F15 DiscussionIn his James Arthur lecture Pribram raised questions about the coding of information in the brain and about the complex association between language, symbol, and the unique human cognitive system. These questions are as pertinent today as in 1970. The emergence of modern human symbolic cognition is often viewed as a gradual, incremental process, governed by inexorable natural selection and propelled by the apparent advantages of increasing intelligence. However, there are numerous theoretical considerations that render such a scenario implausible, and an examination of the pattern of acquisition of behavioral and anatomical novelties in human evolution indicates that, throughout, major change was both sporadic and rare. What is more, modern bony anatomy and brain size were appare... Journal of Biomedical Discovery and Collaboration journals http://www.medworm.com/rss/comments.php?id=361470 Wed, 29 Nov 2006 07:00:00 +0100 361470 http://www.medworm.com/index.php?rid=361474&cid=s_34074_61_f&fid=34074&url=http%3A%2F%2Fwww.j-biomed-discovery.com%2Fcontent%2F1%2F1%2F12 One of the most pressing and timely scientific questions concerns the evolution of man. In 1970, Karl Pribram delivered the James Arthur Lecture at the American Museum of Natural History in New York City. His lecture, "What Makes Man Human," was one of the most eloquent and brilliant syntheses of this problem ever made. The Journal is proud to publish this Lecture for the first time in an open access format that will make its insights available widely to a new generation of students and investigators. Accompanying the lecture is a new commentary written by Prof. Pribram, and four additional commentaries from prominent investigators who were invited to consider the question from their own perspectives. Together, these articles provide a scholarly, yet accessible, snapshot of different appro... Journal of Biomedical Discovery and Collaboration journals http://www.medworm.com/rss/comments.php?id=361474 Tue, 28 Nov 2006 07:00:00 +0100 361474 http://www.medworm.com/index.php?rid=361475&cid=s_34074_61_f&fid=34074&url=http%3A%2F%2Fwww.j-biomed-discovery.com%2Fcontent%2F1%2F1%2F10 Conclusion: We present a functional, working tool to permit users to populate knowledge bases for neuroanatomical connectivity data from the literature through the use of structured questionnaires. This system is open-source, fully functional and available for download from 1. (Source: Journal of Biomedical Discovery and Collaboration) Journal of Biomedical Discovery and Collaboration journals http://www.medworm.com/rss/comments.php?id=361475 Tue, 08 Aug 2006 06:00:00 +0100 361475