MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Journal of Cancer Research and Clinical Oncology' source. Fri, 19 Mar 2010 13:58:36 +0100 http://www.medworm.com/index.php?rid=3375455&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F66u30x37563q380x%2F Conclusions  Smoking dosage affects the incidence of EGFR mutations. EGFR mutations in exon 19 or 21 are associated with low exposure to cigarette smoke, whereas EGFR mutation in exon 20 is more common in smokers. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0853-4Authors Young Joo Lee, National Cancer Center Center for Clinical Trial Gyeonggi Republic of KoreaHyo Sub Shim, Yonsei University College of Medicine Department of Pathology Seoul Republic of KoreaYoung Ae Kang, Yonsei University College of Medicine Department of Internal Medicine Seoul Republic of KoreaSu Jung Hong, Yonsei University College of Medicine Yonsei Cancer Center, Division of Medical Oncology, Department of Internal Medicine 250 Seongsanno CPO Box 8044 Seodaemun-gu, Se... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3375455 Tue, 16 Mar 2010 14:49:23 +0100 3375455 http://www.medworm.com/index.php?rid=3366952&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fgu572363427w26p0%2F Conclusions  The combined effects of putative risk alleles/genotypes for different DNA repair pathways may strengthen the susceptibility to rectal cancer. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0809-8Authors Jingwen Wang, Nagoya City University Graduate School of Medical Sciences Department of Public Health Mizuho-ku Nagoya 467-8601 JapanYang Zhao, Nagoya City University Graduate School of Medical Sciences Department of Public Health Mizuho-ku Nagoya 467-8601 JapanJing Jiang, The First Hospital, Jilin University Department of Hematology and Oncology Changchun ChinaVendhan Gajalakshmi, Epidemiological Research Center Chennai IndiaKiyonori Kuriki, University of Shizuoka Hygiene and Preventive Medicine, School of Food and Nutritional Sc... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3366952 Sun, 14 Mar 2010 11:26:27 +0100 3366952 http://www.medworm.com/index.php?rid=3366953&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F878144kp1271080q%2F This study analyzed the genetic alterations associated with this pathological heterogeneity in order to identify the genetic processes involved in transformation from a benign to an aggressive malignant tumor. Methods  A histological and molecular analysis of a single MPNST tumor that was subdivided into three histopathologically distinct regions, a benign PNF (region 1), an atypical PNF (region 2), and a high-grade MPNST (region 3), was carried out. Tumor DNA from each region was analyzed in conjunction with the patient’s lymphocyte DNA. Somatic mutation analyses included loss-of heterozygosity (LOH), MLPA analysis, NF1 gene sequencing, and a microarray comparative genomic hybridisation (array CGH) analysis. Results  The patient had a germline ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3366953 Sun, 14 Mar 2010 11:26:26 +0100 3366953 http://www.medworm.com/index.php?rid=3366954&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fylr357227773412q%2F Conclusion  Celecoxib effectively prevents the development of chemoresistance in breast cancer cell line MCF-7 induced by doxorubicin, which was partly involved in inhibiting the expression and DNA-binding activity of nuclear transcription factors AP-1 and NF-κB and downstream expression and function of P-gp. Furthermore, cytostatic efficacy of celecoxib and doxorubicin on MCF-7 cell was synergistic. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0854-3Authors Chen Chen, Jiangsu University The Affiliated People’s Hospital Zhenjiang People’s Republic of ChinaHui Ling Shen, Jiangsu University The Affiliated People’s Hospital Zhenjiang People’s Republic of ChinaJing Yang, Jiangsu University The Affiliated People’s Hospital Zhenjian... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3366954 Sun, 14 Mar 2010 11:26:24 +0100 3366954 http://www.medworm.com/index.php?rid=3366956&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe607602466560454%2F Conclusion  The novel recombinant TR DNA vaccine targeting at MUC1 of pancreatic cancer was constructed successfully, effectively expressing TR polypeptide in the transfected mammalian cells and inducing TR-specific CTL and antibody response. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0845-4Authors Wen-Chuan Wu, Fudan University Department of General Surgery, Zhongshan Hospital 180 Feng Lin Road Shanghai 200032 People’s Republic of ChinaDa-Yong Jin, Fudan University Department of General Surgery, Zhongshan Hospital 180 Feng Lin Road Shanghai 200032 People’s Republic of ChinaWen-Hui Lou, Fudan University Department of General Surgery, Zhongshan Hospital 180 Feng Lin Road Shanghai 200032 People’s Republic of ChinaDan-Song Wang, Fudan... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3366956 Sun, 14 Mar 2010 11:26:23 +0100 3366956 http://www.medworm.com/index.php?rid=3366955&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx453763200481142%2F Abstract  MicroRNAs (miRNAs) are small non-coding RNAs that play important roles in regulation of eukaryotic gene expression. Aberrant expression and structural alternation of miRNAs are considered to participate in tumorigenesis and cancer development. Recently, different genotypes of miR-196a polymorphisms (SNP, rs11614913) were found to be associated with the survival of patients with lung cancer and increased risk of breast cancer. To further investigate whether this polymorphism may influence glioma risk or not, we examined the SNP allele frequency in Chinese population. Our data shows the genotype CC of miR-196a (rs11614913) polymorphism is associated with decreased risk of glioma in the Chinese population (OR = 0.74, 95% CI:0.56–0.98). Furthermore, a signi... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3366955 Sun, 14 Mar 2010 11:26:23 +0100 3366955 http://www.medworm.com/index.php?rid=3366957&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F631458ur11m32788%2F Conclusion  The inverse correlation between PEDF expression and MVD in human breast cancer suggests that low PEDF expression is associated with angiogenesis in breast cancer. PEDF expression is therefore a potentially useful prognostic marker for breast cancer. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0830-yAuthors Dan Zhou, Harbin Medical University Department of Breast Surgery, Tumor Hospital 158 HaPing Road Harbin 150081 ChinaShao-Qiang Cheng, Harbin Medical University Department of Breast Surgery, Tumor Hospital 158 HaPing Road Harbin 150081 ChinaHong-Fei Ji, Institute of Tumor Research of Harbin Medical University Harbin ChinaJin-Song Wang, Harbin Medical University Department of Breast Surgery, Tumor Hospital 158 HaPing Road Harb... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3366957 Sun, 14 Mar 2010 11:26:22 +0100 3366957 http://www.medworm.com/index.php?rid=3363232&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2r22336q53524735%2F Conclusions  Our observations hint to an oncogenic function of PI3Kγ in distinct neuroblastoma entities and reveal PI3K targeting by AS605240 as a promising molecular therapy of these tumors. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0847-2Authors Volker Spitzenberg, Jena University Hospital Department of Molecular Cell Biology, Center for Molecular Biomedicine Hans-Knöll-Strasse 2 Jena 07745 GermanyChristian König, Jena University Hospital Department of Molecular Cell Biology, Center for Molecular Biomedicine Hans-Knöll-Strasse 2 Jena 07745 GermanySusanne Ulm, Jena University Hospital Childrens Hospital Jena GermanyRomina Marone, University of Basel Institute of Biochemistry and Genetics, Department for Biomedicine Basel Switzerlan... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3363232 Fri, 12 Mar 2010 06:48:47 +0100 3363232 http://www.medworm.com/index.php?rid=3363233&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F193715344404g4r6%2F Conclusion  In all, the DocMitoCape regimen exhibited a favorable safety profile and a high rate of tumor stabilizations in patients with pre-treated gallbladder, bile duct and pancreatic carcinoma. It might be considered after failure of standard regimens in these types of cancer. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0843-6Authors Jens Kruth, Universitätsmedizin Mannheim, Ruprecht-Karls-Universität Heidelberg III. Medizinische Klinik, Hämatologie und Onkologie Theodor-Kutzer-Ufer 1-3 68167 Mannheim GermanyJohanna Nissen, Universitätsmedizin Mannheim, Universität Heidelberg Institut für Klinische Radiologie und Nuklearmedizin Theodor-Kutzer-Ufer 1-3 68167 Mannheim GermanyThomas Ernst, Universitätsmedizin Mannheim, Ruprecht-... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3363233 Fri, 12 Mar 2010 06:48:45 +0100 3363233 http://www.medworm.com/index.php?rid=3360333&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj31k042116002887%2F Conclusions  Intratumoral high Foxp3+ Tregs/CD8+ ratio was an independent predictor for the prognosis of gastric cancer. It can be inferred that a combination of deletion of Tregs and stimulation of CD8+ effector T cells may be an effective immunotherapy to prolong survival after surgery. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0816-9Authors Zhengbin Shen, Fudan University The General Surgery Department of Zhongshan Hospital Shanghai ChinaShuang Zhou, Fudan University The Department of Anatomy and Histology and Embryology, Shanghai Medical College Shanghai ChinaYanna Wang, Fudan University The General Surgery Department of Zhongshan Hospital Shanghai ChinaRi-lun Li, Fudan University The Department of Anatomy and Histology and Embryol... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3360333 Thu, 11 Mar 2010 07:57:29 +0100 3360333 http://www.medworm.com/index.php?rid=3360334&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0706r8u613060031%2F Conclusion   In summary, our results identify both PPARγ and PPARβ/δ as an alternative COX-independent mechanism of VEGF induction in colorectal tumor cells. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0856-1Authors Clemens Röhrl, Medical University of Vienna Department of Medicine 1, Clinic for Internal Medicine I, Institute of Cancer Research Borschkegasse 8a 1090 Vienna AustriaUlrike Kaindl, Medical University of Vienna Department of Medicine 1, Clinic for Internal Medicine I, Institute of Cancer Research Borschkegasse 8a 1090 Vienna AustriaInga Koneczny, Medical University of Vienna Department of Medicine 1, Clinic for Internal Medicine I, Institute of Cancer Research Borschkegasse 8a 1090 Vienna AustriaXenia Hudec, Medical Univer... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3360334 Thu, 11 Mar 2010 02:40:43 +0100 3360334 http://www.medworm.com/index.php?rid=3360335&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp1q6t63560222007%2F Conclusion  This in vitro data by being supported with clinical data may open the way of the potential use of CAPE for the treatment of leukemia. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0857-0Authors Çığır Biray Avcı, Ege University Department of Medical Biology, School of Medicine Bornova Izmir 35100 TurkeyCumhur Gündüz, Ege University Department of Medical Biology, School of Medicine Bornova Izmir 35100 TurkeyYusuf Baran, Izmir Institute of Technology Department of Molecular Biology and Genetics Urla 35430 TurkeyFahri Şahin, Ege University Department of Hematology, School of Medicine Bornova Izmir 35100 TurkeySunde Yılmaz, Ege University Department of Medical Biology, School of Medicine Bornova Izmir 35100 TurkeyZeynep Ozle... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3360335 Thu, 11 Mar 2010 02:40:42 +0100 3360335 http://www.medworm.com/index.php?rid=3360336&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx2m2h21w450m8890%2F Conclusion  These data indicated that DAF siRNA described in this study may offer an additional alternative to improve the efficacy of antibody- and complement-based cancer immunotherapy. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0862-3Authors Ling-Juan Gao, Nanjing Maternity and Child Health Care Hospital Clinical Laboratory Tianfei Alley, Nanjing Mochou Road Nanjing 210004 People’s Republic of ChinaLan Ding, Fudan University Department of Otorhinolaryngology, EENT Hospital Shanghai People’s Republic of ChinaShu-Yu Guo, Southern Medical University Clinical Laboratory Guangzhou People’s Republic of ChinaYou-Qun Cai, Nanjing Maternity and Child Health Care Hospital Clinical Laboratory Tianfei Alley, Nanjing Mochou Road Nanjing 2100... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3360336 Thu, 11 Mar 2010 02:40:40 +0100 3360336 http://www.medworm.com/index.php?rid=3360338&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw667979547533kx1%2F Conclusions  System chemotherapy for advanced breast cancer lead to a significant decrease in serum VEGF level in patients with disease control, and this anti-VEGF efficacy may be mainly due to the reduction in tumor burden. Sequential measurement of serum VEGF could be useful for evaluating treatment efficacy and prognosis. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0859-yAuthors Jin-Hai Tang, Jiangsu Cancer Hospital Department of General Surgery Baziting 42 210009 Nanjing ChinaJian-Hua Zhao, Jiangsu Cancer Hospital Center of Clinical Laboratory Science 210009 Nanjing ChinaJian-Wei Lu, Jiangsu Cancer Hospital Department of Internal Medicine 210009 Nanjing ChinaFeng Yan, Jiangsu Cancer Hospital Department of Clinical Laboratory 210009 N... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3360338 Thu, 11 Mar 2010 02:40:39 +0100 3360338 http://www.medworm.com/index.php?rid=3360337&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe086p56661657550%2F Conclusion  The increase in frequency of Treg cells might play a role in modulation of the immune response against HCC in different TNM stages. The substance secreted in tumor microenvironment recruited CD4+CD25+ Treg cells to tumor sites to contribute to the prosperity and growth of the tumors. The performance of Treg cells in different TNM stages of tumor microenvironment might be acted as the route to evaluate the immunotherapy-based methods, promote therapy effect, and consequently to increase the survival rate in HCC. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0833-8Authors Xiaohong Shen, Medical School of Nankai University Tianjin 300071 People’s Republic of ChinaNa Li, Medical School of Nankai University Tianjin 300071 People�... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3360337 Thu, 11 Mar 2010 02:40:39 +0100 3360337 http://www.medworm.com/index.php?rid=3355532&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F557735t7518r5677%2F Conclusions  The combination of taxane and SAHA could be efficacious for the treatment of gastric cancer. The genes that were related to the synergistic response to taxane and SAHA could serve as surrogate biomarkers to predict the therapeutic response in gastric cancer patients. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0849-0Authors Hyun Chang, Yonsei University College of Medicine Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center #134, Shinchon-Dong, Seodaemoon-gu Seoul 120-752 KoreaSun Young Rha, Yonsei University College of Medicine Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center #134, Shinchon-Dong, Seodaemoon-gu Seoul 120-752 KoreaHei-Cheul Jeung, Yonsei Unive... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3355532 Wed, 10 Mar 2010 16:10:28 +0100 3355532 http://www.medworm.com/index.php?rid=3355534&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu20242g96705142v%2F Conclusions  Risk factors for survival in a multivariate analysis were remission status prior to transplantation (CR vs. no CR), occurrence of acute and chronic GvHD, and relapse. The use of the CellPro device for CD34 positive selection per se did not have an influence on overall survival. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0851-6Authors Hans-Georg Kopp, University of Tübingen Department of Internal Medicine II, Division of Hematology and Oncology, Immunology, and Rheumatology Tübingen GermanyStefan Wirths, University of Tübingen Department of Internal Medicine II, Division of Hematology and Oncology, Immunology, and Rheumatology Tübingen GermanyChristoph Faul, University of Tübingen Department of Internal Medicine II, Div... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3355534 Wed, 10 Mar 2010 16:10:27 +0100 3355534 http://www.medworm.com/index.php?rid=3355533&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl8515p116g157812%2F Conclusions  The down-regulation of CD99 protein expression is a critical event in the progress of TCC, especially in advanced stage, and it can be explained by the presence of CD99 gene promoter hypermethylation in TCC. And both CD99 protein expression and gene promoter hypermethylation have clinical significance and implication for the diagnosis and target therapy for TCC. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0858-zAuthors Yanhua Xuan, Yanbian University College of Medicine Department of Pathology No. 1829, Juzi St. Yanji 133000 People’s Republic of ChinaSeokhyung Kim, Sungkyunkwan University School of Medicine Department of Surgery, Samsung Medical Center Seoul 110-745 South KoreaZhenhua Lin, Yanbian University College of Med... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3355533 Wed, 10 Mar 2010 16:10:27 +0100 3355533 http://www.medworm.com/index.php?rid=3355535&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk476721125643h55%2F Conclusions  The present study may be of importance in the exploration of the potential application of Lip-mS in the treatment of a broad spectrum of tumors. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0855-2Authors Li Pan, Sichuan University State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School Keyuan Road 4 Chengdu Sichuan People’s Republic of ChinaXing-Chen Peng, Sichuan University State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School Keyuan Road 4 Chengdu Sichuan People’s Republic of ChinaFei Leng, Sichuan University State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School Keyuan Road 4 Chengdu ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3355535 Wed, 10 Mar 2010 16:10:26 +0100 3355535 http://www.medworm.com/index.php?rid=3355537&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa82p15205n127578%2F Conclusions  These results suggest that hypoxia induce the expression of HIF-1α and MDR1/P-gp in colon carcinoma and HIF-1α expression may be associated with the gene MDR1 (P-gp) and interactively involved in the occurrence of tumor multidrug resistance. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0828-5Authors Zhenyu Ding, Third Military Medical University Department of Oncology, Southwest Hospital 30 Gaotanyan Street, Shapingba District Chongqing 400038 ChinaLi Yang, Third Military Medical University Department of Oncology, Southwest Hospital 30 Gaotanyan Street, Shapingba District Chongqing 400038 ChinaXiaodong Xie, General Hospital of Shenyang Military Region Department of Oncology Shenyang 110840 Liaoning ChinaFangwei Xie, Third Mi... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3355537 Wed, 10 Mar 2010 16:10:23 +0100 3355537 http://www.medworm.com/index.php?rid=3355536&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj4k46134005gr544%2F Conclusion  APTB should be considered in all cases with pelvic mass, ascites and high levels of CA125, although clinical features and laboratory results specifically indicate neither ovarian malignancy nor APTB. Diagnostic laparotomy is a direct and safe method. To avoid extended surgery, the cases with APTB can be diagnosed through intra-operative frozen section in conjunction with clinical features. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0842-7Authors Xia Xi, Huazhong University of Science and Technology Cancer Biology Research Center, Tongji Hospital, Tongji Medical College 1095 Jiefang Ave. 430030 Wuhan Hubei People’s Republic of ChinaLi Shuang, Huazhong University of Science and Technology Cancer Biology Research Center, Ton... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3355536 Wed, 10 Mar 2010 16:10:23 +0100 3355536 http://www.medworm.com/index.php?rid=3355540&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F182762745v656172%2F Conclusions  AAV-mediated therapeutic gene expression in combination with chemotherapy provides a promising therapeutic strategy for human cancers. These data suggest that combined use of AAV-hTERT-TRAIL and cisplatin may have potential clinical application. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0841-8Authors Yigang Wang, East China University of Science and Technology State Key Laboratory of Bioreactor Engineering Shanghai 200237 ChinaFang Huang, Zhejiang Sci-Tech University Institute of Xinyuan Medicine and Biotechnology, College of Life Science Hangzhou 310018 ChinaHaibo Cai, East China University of Science and Technology State Key Laboratory of Bioreactor Engineering Shanghai 200237 ChinaYumei Wu, Zhejiang Sci-Tech University I... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3355540 Wed, 10 Mar 2010 16:10:22 +0100 3355540 http://www.medworm.com/index.php?rid=3355539&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F997rg1141866k111%2F Conclusions  IFN-α has janus face of consistently suppressing HCC growth, however, promoting tumor metastasis capacity, which is of clinical indication for the scientific administration of IFN-α and the similar antiangiogenesis drugs for their dual effect on tumor growth and metastasis. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0848-1Authors Peng-Yuan Zhuang, Shanghai Jiao Tong University Department of General Surgery, Xinhua Hospital, School of Medicine Shanghai People’s Republic of ChinaJu-Bo Zhang, Fudan University Liver Cancer Institute and Zhongshan Hospital 200032 Shanghai People’s Republic of ChinaWei Zhang, Fudan University Liver Cancer Institute and Zhongshan Hospital 200032 Shanghai People’s Republic of ChinaXiao-Dong... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3355539 Wed, 10 Mar 2010 16:10:22 +0100 3355539 http://www.medworm.com/index.php?rid=3355538&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh841v06tj1863421%2F Conclusion  The combination of IHC and FISH allows a differentiated analysis of single cells, which is especially important for effusions that are composed of heterogeneous cells. Therefore, cells with high gene amplification and/or protein overexpression can be detected and analysed even if their amount in the sample is small. Chromosome 17 polyploidy is important in some cases but this should be further examined on a larger series. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0790-2Authors Birgitta Schlüter, Klinikum der Ruhr-Universität Bochum Marienhospital Herne, Medizinische Klinik III: Hämatologie und Onkologie Hölkeskampring 40 44625 Herne GermanyRoswitha Gerhards, Klinikum der Ruhr-Universität Bochum Marienhospital Herne, M... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3355538 Wed, 10 Mar 2010 16:10:22 +0100 3355538 http://www.medworm.com/index.php?rid=3355542&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fyu8lxh0762rj4277%2F Abstract  Bladder cancer, in its advanced stage, has very few therapeutic strategies with proven efficacy. Platinum-combination chemotherapy can be considered a standard for first-line therapy, but after progression there is no standard therapy, and the prognosis is very poor. The development of targeted therapies in the last few years has significantly changed the prognosis of a wide variety of tumors. In bladder cancer, there is no targeted therapy currently approved for its use in advanced disease. There is evidence that Her-2 amplification and/or overexpression is seen in bladder cancer, and may influence prognosis. Anti-Her-2 drugs, such as trastuzumab or lapatinib, are under investigation in urothelial neoplasms, but there is no phase III trial that has evaluated thei... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3355542 Wed, 10 Mar 2010 16:10:21 +0100 3355542 http://www.medworm.com/index.php?rid=3355541&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F850h1203117q8048%2F Conclusions  Our data suggest that EGFL7 expression is a novel predictive factor for the clinical progression of malignant glioma, and may constitute a therapeutic target for anti-angiogenesis therapy in patients with the disease. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0832-9Authors Chun-hai Huang, Central South University Department of Neurosurgery, Xiangya Hospital No 87 Xiangya Road Changsha 410008 ChinaXue-jun Li, Central South University Department of Neurosurgery, Xiangya Hospital No 87 Xiangya Road Changsha 410008 ChinaYi-zeng Zhou, Jishou University Department of Neurosurgery, First Affiliated Hospital Jishou 416000 ChinaYong Luo, Jishou University Department of Neurosurgery, First Affiliated Hospital Jishou 416000 ChinaCui L... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3355541 Wed, 10 Mar 2010 16:10:21 +0100 3355541 http://www.medworm.com/index.php?rid=3355543&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp620w7p68822j965%2F Conclusions  This study stresses the urgent need for physicians to acknowledge the association between MM and AE, and to inquire thoroughly regarding AE to the patients with MM. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0834-7Authors Nobukazu Fujimoto, Okayama Rosai Hospital Department of Respiratory Medicine 1-10-25 Chikkomidorimachi, Minamiku Okayama 7028055 JapanKeisuke Aoe, National Hospital Organization Yamaguchi-Ube Medical Center Department of Medical Oncology 685 Higashikiwa Ube 7550241 JapanKenichi Gemba, Okayama Rosai Hospital Department of Respiratory Medicine 1-10-25 Chikkomidorimachi, Minamiku Okayama 7028055 JapanKatsuya Kato, Okayama University School of Medicine Department of Radiology 2-5-1 Shikatacho, Kitaku Okayama 70... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3355543 Wed, 10 Mar 2010 16:10:20 +0100 3355543 http://www.medworm.com/index.php?rid=3355544&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx33p702217176575%2F Conclusion  Our results indicate that SPR may be a useful proteomic technique for quantitative assessment of COX-2 and to identify patients with high-risk oral premalignant or occult cancer, as well as in monitoring response to novel COX-2 targeting strategies. Furthermore, COX-2 peptide inhibitors appear to be a new class of potent anticancer agent for human oral carcinoma. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0837-4Authors Vaishali Kapoor, All India Institute of Medical Sciences Tumor Biology and Molecular Immunology Laboratory, Department of Biotechnology Ansari Nagar New Delhi 110029 IndiaAbhay K. Singh, All India Institute of Medical Sciences Department of Biophysics Ansari Nagar New Delhi 110029 IndiaSharmistha Dey, All Indi... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3355544 Wed, 10 Mar 2010 16:10:17 +0100 3355544 http://www.medworm.com/index.php?rid=3355546&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fwr53j82u50wp5235%2F Conclusions  Our data suggest that the FAS 1377G>A and IL10 592C>A polymorphisms could modify disease-free and overall survival in women with lymph node-positive breast cancer. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0839-2Authors Gudrun Knechtel, Medical University Graz Department of Internal Medicine, Division of Oncology Auenbruggerplatz 15 8036 Graz AustriaGünter Hofmann, Medical University Graz Department of Internal Medicine, Division of Oncology Auenbruggerplatz 15 8036 Graz AustriaArmin Gerger, Medical University Graz Department of Internal Medicine, Division of Oncology Auenbruggerplatz 15 8036 Graz AustriaWilfried Renner, Medical University Graz Clinical Institute of Medical and Laboratory Diagnostics Auenbruggerplatz... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3355546 Wed, 10 Mar 2010 16:10:16 +0100 3355546 http://www.medworm.com/index.php?rid=3355545&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe1k0l000180256wg%2F Conclusions  Reduced expression of PRDM5 may play an important role in the pathogenesis and/or development of cervical cancer, and is considered to be caused in part by aberrant DNA methylation. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0840-9Authors Hai-Yan Cheng, The Tumor Hospital of Harbin Medical University Department of Gynecologic Oncology 150 Haping Road Heilongjiang 150081 ChinaXiu-Wei Chen, The Tumor Hospital of Harbin Medical University Department of Gynecologic Oncology 150 Haping Road Heilongjiang 150081 ChinaLi Cheng, The Tumor Hospital of Harbin Medical University Department of Gynecologic Oncology 150 Haping Road Heilongjiang 150081 ChinaYun-Duo Liu, The Tumor Hospital of Harbin Medical University Department of Gynecolog... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3355545 Wed, 10 Mar 2010 16:10:16 +0100 3355545 http://www.medworm.com/index.php?rid=3355548&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv75l4r3635010w87%2F Conclusion  Our results support the possibility that anti-depressant drugs that target MAOA might find a new application in treating PCa. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0835-6Authors Vincent Flamand, Stanford University School of Medicine Department of Urology, Stanford Medical Center Stanford CA 94305-5118 USAHongjuan Zhao, Stanford University School of Medicine Department of Urology, Stanford Medical Center Stanford CA 94305-5118 USADonna M. Peehl, Stanford University School of Medicine Department of Urology, Stanford Medical Center Stanford CA 94305-5118 USA Journal Journal of Cancer Research and Clinical OncologyOnline ISSN 1432-1335Print ISSN 0171-5216 (Source: Journal of Cancer Research and Clinical Oncology) Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3355548 Wed, 10 Mar 2010 16:10:15 +0100 3355548 http://www.medworm.com/index.php?rid=3355547&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd314457342u82764%2F Conclusion  Our results demonstrate that PI3K/Akt and GSK-3β prevents in a differential fashion the malignant phenotype of HCT-116 colorectal cancer cells, which could constitute a potential therapeutic target for treatment of this cancer type. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0836-5Authors Wallace Martins de Araújo, Instituto Nacional de Câncer, Rio de Janeiro Divisão de Biologia Celular Rua André Cavalcanti 37, 5° andar 20230-051 Rio de Janeiro RJ BrazilFlavia Castello Branco Vidal, Instituto Nacional de Câncer, Rio de Janeiro Divisão de Biologia Celular Rua André Cavalcanti 37, 5° andar 20230-051 Rio de Janeiro RJ BrazilWaldemir Fernandes de Souza, Instituto Nacional de Câncer, Rio de Janeiro Divisão de Biologia ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3355547 Wed, 10 Mar 2010 16:10:15 +0100 3355547 http://www.medworm.com/index.php?rid=3355550&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu6536777507m3021%2F Conclusions  While CK19 and gal-3 are accurate as tissue markers, their serum levels could not be used as reliable markers for identification of thyroid malignancy or in thyroid cancer follow-up. On the other hand, a tendency toward higher serum levels of Cyfra 21.1 in the small number of PDTC patients examined adds weight to previous reports postulating a role for cytokeratins in predicting a high degree of malignancy. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0838-3Authors Tijana Išić, University of Belgrade Institute for the Application of Nuclear Energy, INEP Banatska 31b 11080 Zemun, Belgrade SerbiaSvetlana Savin, University of Belgrade Institute for the Application of Nuclear Energy, INEP Banatska 31b 11080 Zemun, Belgrade Ser... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3355550 Wed, 10 Mar 2010 16:10:14 +0100 3355550 http://www.medworm.com/index.php?rid=3355549&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc611601u22644gr4%2F Conclusions  In patients with LM an age >50, performance status ≤70%, interval between diagnosis of primary tumor and LM ≤12 months, primary tumor (lung cancer, malignant melanoma) and lack of cytologic response present negative prognostic factors. Systemic chemotherapy is significantly associated with longer survival time than local treatment modalities. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0831-xAuthors Karin Oechsle, University Cancer Center Hamburg-Eppendorf Department of Oncology/Hematology/Bone Marrow Transplantation/Pneumology Martinistr. 52 20246 Hamburg GermanyVictoria Lange-Brock, University Cancer Center Hamburg-Eppendorf Department of Oncology/Hematology/Bone Marrow Transplantation/Pneumology Martinistr. 52... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3355549 Wed, 10 Mar 2010 16:10:14 +0100 3355549 http://www.medworm.com/index.php?rid=3355551&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk4256j7306t2h66w%2F Conclusions  This study suggests that silencing Li-cadherin has positive actions in the processes of LoVo cells invasion and metastasis, and the interactions among MMP-2, MMP-9, and Li-cadherin participate in the multiple steps of invasion and metastasis in LoVo colorectal cancer cells. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0822-yAuthors Qiong-Fang Yu, Second Affiliated Hospital of Nanchang University Department of Gastroenterology Nanchang Jiangxi ChinaWei-Guo Dong, Renmin Hospital of Wuhan University Department of Gastroenterology 238 Jiefang Road Wuhan 430060 Hubei People’s Republic of ChinaJian-Lin Ren, Xiamen University Department of Gastroenterology, Zhongshan Hospital Xiamen Fujian China Journal Journal of Cancer Re... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3355551 Wed, 10 Mar 2010 16:10:13 +0100 3355551 http://www.medworm.com/index.php?rid=3355553&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2r230h15p5650023%2F Conclusions  Beta2-GPI may play a role in the development of HBV-related HCC by activating NF-κB via interaction of beta2-GPI and HBsAg. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0825-8Authors Xue Jing, The First Hospital of Jilin University Department of Hepatology Changchun 130021 Jilin Province People’s Republic of ChinaYun-Feng Piao, The First Hospital of Jilin University Department of Hepatology Changchun 130021 Jilin Province People’s Republic of ChinaYe Liu, Academy of Military Medical Sciences Laboratory of Epidemiology, Veterinary Institute Changchun People’s Republic of ChinaPu-Jun Gao, The First Hospital of Jilin University Department of Hepatology Changchun 130021 Jilin Province People’s Republic of China Journa... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3355553 Wed, 10 Mar 2010 16:10:10 +0100 3355553 http://www.medworm.com/index.php?rid=3355552&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj6725241334m4868%2F Conclusions  Results of RNA-based multi-gene analyses of the prognostic and predictive markers HER2 and uPA correlate with the corresponding protein levels. This is not the case for PAI-1. However, PAI-1 mRNA expression might reveal new clinically relevant information in addition to PAI protein levels. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0829-4Authors Isabell D. Witzel, University Medical Center Hamburg-Eppendorf Department of Gynecology Martinistrasse 52 20246 Hamburg GermanyKarin Milde-Langosch, University Medical Center Hamburg-Eppendorf Department of Gynecology Martinistrasse 52 20246 Hamburg GermanyRalph M. Wirtz, Siemens Healthcare Diagnostics Products GmbH Cologne GermanyClaudia Roth, Siemens Healthcare Diagnostics Product... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3355552 Wed, 10 Mar 2010 16:10:10 +0100 3355552 http://www.medworm.com/index.php?rid=3312726&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw71265016314g603%2F Conclusions  Our results suggest that a decrease in nuclear ING5 localization and cytoplasmic translocation are involved in tumorigenesis and tumor differentiation in HNSCC. Nuclear ING5 may modulate the transactivation of target genes, and may promote apoptosis and cell cycle arrest by interacting with the p300 and p21 proteins. ING5 may function as a tumor suppressor gene or oncogene tightly linked with p53 status, and may play an important role in the prognosis of HNSCC patients. Therefore, we propose that ING5 represents a novel potential molecular therapeutic target for HNSCC. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0815-xAuthors Xiaohan Li, University of Toyama Department of Diagnostic Pathology, Graduate School of Medicine a... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3312726 Thu, 25 Feb 2010 06:53:02 +0100 3312726 http://www.medworm.com/index.php?rid=3312725&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F611w94q868363382%2F Conclusions  KLF8 possibly involved in regulating the cell growth, invasion, apoptosis, and proliferation of renal carcinoma cancer cells. Blocking the KLF8 channel might be a potential therapeutic strategy for RCC. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0776-0Authors Wei-Jin Fu, The First Affiliated Hospital of Guangxi Medical University Department of Urology Guangxi People’s Republic of ChinaJia-Chu Li, The First Affiliated Hospital, Chongqing Medical University Department of Oncology Chongqing People’s Republic of ChinaXiao-yun Wu, RuiKang Hospital of GuangXi Traditional Chinese Medical University Department of Nephrology Nanning People’s Republic of ChinaZhan-Bing Yang, The First Affiliated Hospital of Guangxi Medical Unive... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3312725 Thu, 25 Feb 2010 06:53:02 +0100 3312725 http://www.medworm.com/index.php?rid=3303642&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg782057880023j78%2F Conclusion  This data set suggests that long-term administration of temozolomide is safe and efficacious. Side effects occur more frequently in the early phase of drug administration (<6 cycles). There is a strong correlation of long-term temozolomide on PFS and OS regardless of the extent of surgery and other factors. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0827-6Authors Marcel Seiz, University Medical Center Mannheim Department of Neurosurgery Theodor-Kutzer-Ufer 1-3 68167 Mannheim GermanyUlrich Krafft, University Medical Center Mannheim Department of Neurosurgery Theodor-Kutzer-Ufer 1-3 68167 Mannheim GermanyChristian F. Freyschlag, University Medical Center Mannheim Department of Neurosurgery Theodor-Kutzer-Ufer 1-3 68167... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3303642 Tue, 23 Feb 2010 07:20:33 +0100 3303642 http://www.medworm.com/index.php?rid=3303641&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F170p20u43nr03627%2F Conclusions  Our data indicated that p53, BRCA1, ATM, PIK3CA, and HER2 alterations specifically correlate with clinicopathological characteristics of Bulgarian patients with breast cancer. Of these genes, only mutated p53 showed significant, though not independent, negative effect on overall survival. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0824-9Authors Stefan S. Bozhanov, Bulgarian Academy of Sciences Institute of Genetics “Akad. Doncho Kostoff”, Department of Molecular Genetics “Plovdivsko shosse” 13 km. 1113 Sofia BulgariaSvetla G. Angelova, Bulgarian Academy of Sciences Institute of Genetics “Akad. Doncho Kostoff”, Department of Molecular Genetics “Plovdivsko shosse” 13 km. 1113 Sofia BulgariaMaria E. Krasteva, ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3303641 Tue, 23 Feb 2010 07:20:33 +0100 3303641 http://www.medworm.com/index.php?rid=3295532&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4728q77vw8w76807%2F Conclusion  MDR of MCF-7/5-FU likely associated with differentially expressed proteins and 14-3-3σ may play a positive role in chemotherapy. These findings may provide theoretical support for the prediction of chemotherapeutic response and reverse of MDR. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0805-zAuthors Guopei Zheng, Central South University Cancer Research Institute, Xiangya School of Medicine Xiangya Road #110 Changsha 410078 Hunan People’s Republic of ChinaFang Peng, Central South University Key Laboratory of Cancer Proteomics of Ministry of Health of China, Xiangya Hospital 87# Xiangya Road Changsha 410078 Hunan People’s Republic of ChinaRenkui Ding, Central South University Cancer Research Institute, Xiangya School of M... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3295532 Sun, 21 Feb 2010 06:54:36 +0100 3295532 http://www.medworm.com/index.php?rid=3295533&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu6284gp1m2466677%2F In this study, we were able to distinguish between classical Hodgkin lymphoma and lymphadenitis with a sensitivity and specificity of 83.92 and 89.37%, respectively. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0823-xAuthors Kristina Schwamborn, RWTH Aachen University Institute of Pathology Aachen GermanyRené C. Krieg, RWTH Aachen University Institute of Pathology Aachen GermanyPeggy Jirak, RWTH Aachen University Institute of Pathology Aachen GermanyGerman Ott, Robert-Bosch-Krankenhaus Institute of Pathology Stuttgart GermanyRuth Knüchel, RWTH Aachen University Institute of Pathology Aachen GermanyAndreas Rosenwald, University of Wurzburg Institute of Pathology Würzburg GermanyAxel Wellmann, Institute of Pathology Celle Wittinger Strasse 14 29223 Cel... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3295533 Sun, 21 Feb 2010 06:54:35 +0100 3295533 http://www.medworm.com/index.php?rid=3295534&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F37457h512053775x%2F Conclusion  Since metastases can be considered as natural secondary tumor implants in a tumor-bearing host and that they constitute the main problem in cancer pathology, the use of the concept of hormesis to describe those biphasic effects might have significant clinical implications. In effect, if the tumor-bearing host were placed in the inhibitory window, tumor extirpation could enhance the growth of distant metastases and, reciprocally, if placed in the stimulatory window, tumor extirpation would result not only in a reduction or elimination of primary tumor load but also in a slower growth or inhibition of metastases. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0818-7Authors Juan Bruzzo, Academia Nacional de Medicina de Buenos Air... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3295534 Sun, 21 Feb 2010 06:54:34 +0100 3295534 http://www.medworm.com/index.php?rid=3295535&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft44l441477562205%2F Conclusion   125I brachytherapy combined with sorafenib is safe, feasible and promising approach in the treatment of patients with multiple lung metastases after OLT for HCC, but large-scale randomized clinical trials are necessary for confirmation. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0821-zAuthors Chuanxing Li, Sun Yat-sen University Department of Medical Imaging and Interventional Radiology, Cancer Center and State Key Laboratory of Oncology in South China 651 Dongfeng Road, East Guangzhou 510060 Guangdong People’s Republic of ChinaFujun Zhang, Sun Yat-sen University Department of Medical Imaging and Interventional Radiology, Cancer Center and State Key Laboratory of Oncology in South China 651 Dongfeng Road, East Guangzhou 5... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3295535 Sun, 21 Feb 2010 06:54:33 +0100 3295535 http://www.medworm.com/index.php?rid=3295537&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fdt7m327526n13442%2F Conclusions  The short axis diameter enlargement has a relative plateau within 10 min by fixing power output to 60 or 80 W, using the 2,450-MHz internally cooled-shaft antenna in vivo porcine livers. Effective local tumor control was achieved during one microwave ablation session. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0808-9Authors Dechao Jiao, Sun Yat-sen University Department of Medical Imaging and Interventional Radiology, Cancer Center and State Key Laboratory of Oncology in South China 651 Dongfeng Road, East Guangzhou 510060 Guangdong People’s Republic of ChinaLinxue Qian, Beijing Friendship Hospital Affiliated of Capital Medical University Department of Diagnostic Ultrasound Beijing 100050 People’s Republic of ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3295537 Sat, 20 Feb 2010 06:50:29 +0100 3295537 http://www.medworm.com/index.php?rid=3295536&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fmw1kk56v502248q2%2F Conclusions  Taken together, our findings suggest that Nutlin-3 will be active in the treatment of HCC and offers new prospects for overcoming DOX resistance. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0817-8Authors Tongsen Zheng, The First Affiliated Hospital of Harbin Medical University Department of General Surgery No. 23 Youzheng Street Harbin 150001 Heilongjiang Province ChinaJiabei Wang, The First Affiliated Hospital of Harbin Medical University Department of General Surgery No. 23 Youzheng Street Harbin 150001 Heilongjiang Province ChinaXuan Song, The First Affiliated Hospital of Harbin Medical University Department of General Surgery No. 23 Youzheng Street Harbin 150001 Heilongjiang Province ChinaXianzhi Meng, The First Affiliate... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3295536 Sat, 20 Feb 2010 06:50:29 +0100 3295536 http://www.medworm.com/index.php?rid=3295538&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F434487521152hl22%2F Conclusions  Cyclin D1 overexpression seems to be more important during early T-categories of bladder carcinogenesis, whereas cyclin D3 is implicated in the acquisition of a more aggressive phenotype. Cyclin D3 overexpression emerges as an independent adverse prognostic marker in both superficial and muscle-invasive tumours. Cyclin D1 is an independent indicator of shortened survival only in muscle-invasive tumours. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0814-yAuthors Georgia Levidou, Laiko Hospital, National and Kapodistrian University of Athens First Department of Pathology 11527 Athens GreeceAngelica A. Saetta, Laiko Hospital, National and Kapodistrian University of Athens First Department of Pathology 11527 Athens GreeceMaria K... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3295538 Sat, 20 Feb 2010 06:50:28 +0100 3295538 http://www.medworm.com/index.php?rid=3295539&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fut14w0413737527q%2F Conclusion  Elevated CEA (≥5 ng/ml) and CA19-9 (≥500 U/ml) levels have an association with diabetic pancreatic cancer. New-onset diabetes combined with higher CA 19-9 and/or CEA might be regarded as a useful tool to screen early pancreatic cancer. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0820-0Authors Qingqu Guo, Cancer Institute, Zhejiang University Department of Surgery, The Second Affiliated Hospital, College of Medicine 88# Jiefang Road Hangzhou 310009 People’s Republic of ChinaMuxing Kang, Cancer Institute, Zhejiang University Department of Surgery, The Second Affiliated Hospital, College of Medicine 88# Jiefang Road Hangzhou 310009 People’s Republic of ChinaBo Zhang, Cancer Institute, Zhejiang University Departm... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3295539 Sat, 20 Feb 2010 06:50:27 +0100 3295539 http://www.medworm.com/index.php?rid=3289075&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft9l48t8p8338r4m3%2F Conclusions  Perineural invasion is seen in about one-third of patients with cervical carcinoma. Patients affected by PNI represented a decreased overall survival. Further studies are required to get a deeper insight into the clinical impact and the pathogenetic mechanisms of PNI in CX. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0813-zAuthors Lars-Christian Horn, University of Leipzig Division of Breast Gynecologic and Perinatal Pathology, Institute of Pathology Liebigstrasse 26 04103 Leipzig GermanyAlexandra Meinel, University of Leipzig Division of Breast Gynecologic and Perinatal Pathology, Institute of Pathology Liebigstrasse 26 04103 Leipzig GermanyUta Fischer, University of Leipzig Division of Breast Gynecologic and Perinatal Path... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3289075 Thu, 18 Feb 2010 17:54:28 +0100 3289075 http://www.medworm.com/index.php?rid=3285108&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd468312v738h873n%2F Conclusions  The thymidylate synthase genotype might help to identify patients with stage II/III rectal cancer who could benefit from pre- and postoperative fluorouracil-based chemotherapy. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0826-7Authors David Páez, Universitat Autònoma de Barcelona Department of Medical Oncology, Hospital de la Santa Creu i Sant Pau Pare Claret 167 08025 Barcelona SpainLaia Paré, Universitat Autònoma de Barcelona Department of Genetics, Hospital de la Santa Creu i Sant Pau Pare Claret 167 08025 Barcelona SpainAlbert Altés, Althaia Foundation Department of Hematology Av. Bases de Manresa 6-8 08242 Manresa SpainFrancesc Josep Sancho-Poch, Universitat Autònoma de Barcelona Department of Pathology, Hospital d... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3285108 Wed, 17 Feb 2010 18:28:00 +0100 3285108 http://www.medworm.com/index.php?rid=3277094&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2620081036n37v83%2F Conclusion  TXNDC5 can promote the growth and proliferation of gastric cells. Silencing of TXNDC5 can restrain the growth and proliferation of gastric cancer cells. The gene can enhance the capability of invasion of gastric cancer cells. In some respects, TXNDC5 could be thought as a tumor-enhancing gene in gastric cancer. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0807-xAuthors Lin Zhang, The 309 Hospital of PLA Department of Gastroenterology and Hepatology Beijing 100091 ChinaYanhong Hou, The 309 Hospital of PLA Department of Gastroenterology and Hepatology Beijing 100091 ChinaNan Li, The 309 Hospital of PLA Department of Gastroenterology and Hepatology Beijing 100091 ChinaKai Wu, The 309 Hospital of PLA Department of Gastroenterology a... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3277094 Mon, 15 Feb 2010 17:59:48 +0100 3277094 http://www.medworm.com/index.php?rid=3277095&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1v258720781w8632%2F Conclusions  Our data suggested that there had an intensive relationship between pAKT and CD44v6 expression in breast cancer tissues. The overexpression of CD44v6 was an independent prognostic marker for predicting OS and DFS of breast cancer patients. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0779-xAuthors Pei Yu, First People’s Hospital of Shanghai Jiaotong University Department of General Surgery Hongkou District, Room 314, Building 9, No. 85 Wujing Road Shanghai ChinaLing Zhou, First People’s Hospital of Shanghai Jiaotong University Department of General Surgery Hongkou District, Room 314, Building 9, No. 85 Wujing Road Shanghai ChinaWeifeng Ke, First People’s Hospital of Shanghai Jiaotong University Department of General Surger... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3277095 Mon, 15 Feb 2010 17:59:46 +0100 3277095 http://www.medworm.com/index.php?rid=3277096&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8313386158747781%2F Conclusions  Galectin-1 protein expression level increases in OSCC, it may serve as a candidate marker for pathologic differentiation grade of OSCC. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0810-2Authors Lai-ping Zhong, Ninth People’s Hospital, School of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology Department of Oral and Maxillofacial Surgery Shanghai People’s Republic of ChinaKui-jie Wei, Ninth People’s Hospital, School of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology Department of Oral and Maxillofacial Surgery Shanghai People’s Republic of ChinaXiao Yang, Ninth People’s Hospital, School of Stomatology, Shanghai Ji... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3277096 Mon, 15 Feb 2010 17:59:45 +0100 3277096 http://www.medworm.com/index.php?rid=3273496&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6p62725p39308566%2F Conclusions  Deficient expression of SOCS3 is associated with an aggressive phenotype and portends a poor clinical outcome in breast carcinoma. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0819-6Authors Mingzhen Ying, Second Military Medical University Department of Oncology, Changhai Hospital Changhai Road 168 Shanghai 200433 People’s Republic of ChinaDawei Li, Fudan University State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science Shanghai 200433 People’s Republic of ChinaLinjun Yang, Second Military Medical University Department of Oncology, Changhai Hospital Changhai Road 168 Shanghai 200433 People’s Republic of ChinaMei Wang, Second Military Medical University Department of Oncology, Changhai Hos... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3273496 Sun, 14 Feb 2010 06:50:29 +0100 3273496 http://www.medworm.com/index.php?rid=3273498&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Flx175t6uu1245n53%2F Abstract  Distant metastasis represents the major lethal cause of breast cancer. To understand the molecular mechanisms of breast cancer metastasis and identify markers with metastatic potential, we established a highly metastatic variant of parental MDA-MB-231 cells (MDA-MB-231HM). Using two-dimensional electrophoresis (2-DE), we performed a proteomic comparison of the two kinds of cells. As much as 51 protein spots were differentially expressed between the selected variant and its parental counterpart in at least 3 experiments. Ten unique proteins were identified using matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry (MS), liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS), and database searching s... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3273498 Sun, 14 Feb 2010 06:50:28 +0100 3273498 http://www.medworm.com/index.php?rid=3273497&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5k707jvk16828667%2F Conclusions  The EGFR mutations in the serum and the pleural effusion from advanced NSCLC patients can be detected with LightCycle PCR using Taqman-MGB probes. The mutations highly predict the efficacy of gefitinib in advanced NSCLC. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0785-zAuthors Guo Jian, Pulmonary Hospital, Tongji University School of Medicine Department of Oncology Shanghai 200433 People’s Republic of ChinaZhou Songwen, Pulmonary Hospital, Tongji University School of Medicine Department of Oncology Shanghai 200433 People’s Republic of ChinaZhang Ling, Pulmonary Hospital, Tongji University School of Medicine Department of Oncology Shanghai 200433 People’s Republic of ChinaDeng Qinfang, Pulmonary Hospital, Tongji Universit... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3273497 Sun, 14 Feb 2010 06:50:28 +0100 3273497 http://www.medworm.com/index.php?rid=3273500&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6668207u1ww00llv%2F Conclusions  We conclude that 67LR induces FasL expression and FasL-mediated apoptosis through the phosphorylation of c-Myc on Ser-62 and the subsequent activation of the FasL promoter in human cholangiocarcinoma cells. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0804-0Authors Shigang Duan, Third Military Medical University Hepatobiliary Surgery Hospital and Institute, Southwest Hospital Chongqing 400038 ChinaDajiang Li, Third Military Medical University Hepatobiliary Surgery Hospital and Institute, Southwest Hospital Chongqing 400038 ChinaZhanfeng Gao, Third Military Medical University Hepatobiliary Surgery Hospital and Institute, Southwest Hospital Chongqing 400038 ChinaJin Zhu, Third Military Medical University Hepatobiliary Surgery Hosp... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3273500 Sat, 13 Feb 2010 06:46:50 +0100 3273500 http://www.medworm.com/index.php?rid=3273499&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fexq2j3150l47251w%2F Conclusion  Non-significant changes in apoptotic markers with bevacizumab-based chemotherapy showed that they have no prognostic significance in MCRC patients. Significant change in sFAS/sFASL ratio according to treatment response could be an indicator of chemosensitivity. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0803-1Authors Ramazan Yildiz, Gazi University Faculty of Medicine Department of Medical Oncology Besevler Ankara 06500 TurkeyMustafa Benekli, Gazi University Faculty of Medicine Department of Medical Oncology Besevler Ankara 06500 TurkeySuleyman Buyukberber, Gazi University Faculty of Medicine Department of Medical Oncology Besevler Ankara 06500 TurkeyAli Osman Kaya, Gazi University Faculty of Medicine Department of Medical Onco... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3273499 Sat, 13 Feb 2010 06:46:50 +0100 3273499 http://www.medworm.com/index.php?rid=3270389&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F720g9336j75rr235%2F Conclusion  Our results suggest that FAK expression is up-regulated in HCC and its expression is an independent prognostic factor for HCC. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0806-yAuthors Zhou Yuan, The Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University Department of General Surgery 600 Yishan RD Shanghai 200233 ChinaQi Zheng, The Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University Department of General Surgery 600 Yishan RD Shanghai 200233 ChinaJia Fan, Fudan University Liver Cancer Institute and Zhongshan Hospital 180 Fenglin RD Shanghai 200032 ChinaKai-xing Ai, The Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University Department of General Surgery 600 Yishan RD Shanghai 200233... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3270389 Fri, 12 Feb 2010 07:08:38 +0100 3270389 http://www.medworm.com/index.php?rid=3270390&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw614635g6575u4u3%2F Conclusion  The present paper is the first report on p120catenin in invasive breast cancer based on a well-characterized patient material with long-term follow-up. We observed altered expression of p120catenin isoforms in invasive breast cancer and, in our material, the decrease in p120 immunoexpression was significantly associated with poor outcome of disease. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0789-8Authors K. Talvinen, University of Turku Department of Pathology Kiinamyllynkatu 10 20520 Turku FinlandJ. Tuikkala, University of Turku Department of Information Technology 20014 Turun yliopisto FinlandM. Nykänen, Jyväskylä Central Hospital Department of Pathology Keskussairaalantie 19 40620 Jyväskylä FinlandA. Nieminen, Jyväsk... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3270390 Fri, 12 Feb 2010 07:08:36 +0100 3270390 http://www.medworm.com/index.php?rid=3270391&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fmq8345u60u051466%2F Conclusion  Our results indicate that promoter hypomethylation is an important mechanism for high expression of HOXA10 in human ovarian cancer and may be a potential prognostic factor in ovarian cancer. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0772-4Authors Wenjun Cheng, The First Affiliated Hospital of Nanjing Medical University Department of Obstetrics and Gynecology Nanjing 210029 ChinaYi Jiang, The First Affiliated Hospital of Nanjing Medical University Department of Obstetrics and Gynecology Nanjing 210029 ChinaCuixia Liu, The First Affiliated Hospital of Nanjing Medical University Department of Geriatric Medicine Nanjing ChinaOuxi Shen, Nanjing Medical University Key Laboratory of Reproductive Medicine, Institute of Toxicology Nanj... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3270391 Fri, 12 Feb 2010 07:08:35 +0100 3270391 http://www.medworm.com/index.php?rid=3270392&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5442527803x2g31t%2F Conclusions  Since the pathological microscopic venous invasion was not easily available before operation which is limitation for widespread clinical use, thus in practice, we concluded that, for early HCC associated with Child–Pugh A cirrhosis, when tumor size-plus-number is >4, LT provides the best cure; when it is ≤4, HR remains the initial treatment of choice. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0802-2Authors Jian Zhou, Fudan University Liver Cancer Institute, Zhongshan Hospital Shanghai 200032 ChinaZheng Wang, Fudan University Liver Cancer Institute, Zhongshan Hospital Shanghai 200032 ChinaShuang-Jian Qiu, Fudan University Liver Cancer Institute, Zhongshan Hospital Shanghai 200032 ChinaXiao-Wu Huang, Fudan University Li... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3270392 Thu, 11 Feb 2010 11:48:10 +0100 3270392 http://www.medworm.com/index.php?rid=3263838&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe336j241t465k332%2F Conclusions  These results indicate that concurrent inhibition of PI3K and MKP-1 induces apoptosis in KKU-100 cells. Simultaneous targeting of the PI3K pathway and MKP-1 may be a useful approach to improve therapies directed against hilar cholangiocarcinoma. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0811-1Authors Kawin Leelawat, Rajavithi Hospital Department of Surgery Bangkok ThailandWandee Udomchaiprasertkul, Chulabhorn Hospital Cancer Molecular Therapeutics Unit, Chulabhorn Cancer Center Bangkok ThailandSiriluck Narong, Rajavithi Hospital Department of Surgery Bangkok ThailandSurang Leelawat, Rangsit University Faculty of Pharmacy Pathumthani Thailand Journal Journal of Cancer Research and Clinical OncologyOnline ISSN 1432-1335P... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3263838 Tue, 09 Feb 2010 17:36:08 +0100 3263838 http://www.medworm.com/index.php?rid=3263839&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm72040130604g750%2F Conclusions  Our data suggest an association of the GNB3 825TT genotype and better survival in patients with GBM. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0797-8Authors Nicolai El Hindy, University Hospital, University of Duisburg-Essen Department of Neurosurgery Hufelandstraße 55 45122 Essen GermanyMichael Adamzik, University of Duisburg-Essen Department of Anaesthesiology and Intensive Care Medicine Essen GermanyNicole Lambertz, University Hospital, University of Duisburg-Essen Department of Neurosurgery Hufelandstraße 55 45122 Essen GermanyHagen S. Bachmann, University of Duisburg-Essen Institute of Pharmacogenetics Essen GermanyKarl Worm, University of Duisburg-Essen Institute of Pathology and Neuropathology, Medical Faculty Essen G... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3263839 Tue, 09 Feb 2010 17:36:05 +0100 3263839 http://www.medworm.com/index.php?rid=3255800&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu1146185381g8741%2F Conclusions  High-grade breast cancers include both highly sensitive and highly resistant subsets to cytotoxic chemotherapy. Three factors can help discriminate between these subsets. HR-negative and HER2-positive can be predictive of high chemosensitivity. Advanced primary tumor stage can be predictive of high chemoresistance. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0798-7Authors Tomo Osako, Japanese Foundation for Cancer Research Divisions of Pathology, Cancer Institute Hospital 3-8-31, Ariake, Koto-ku Tokyo 135-8550 JapanRie Horii, Japanese Foundation for Cancer Research Divisions of Pathology, Cancer Institute Hospital 3-8-31, Ariake, Koto-ku Tokyo 135-8550 JapanMasaaki Matsuura, Japanese Foundation for Cancer Research Divisions of... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3255800 Mon, 08 Feb 2010 17:29:10 +0100 3255800 http://www.medworm.com/index.php?rid=3255801&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy4u1u33372576mu3%2F Conclusions  This study indicates that PAB has a potential for use against leukemia and its effects might be mediated by inhibiting tubulin polymerization, preventing cell division and activating caspase-3, which leads to apoptosis. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0784-0Authors Guoyi Ma, The University of Mississippi The National Center for Natural Products Research, School of Pharmacy University MS 38677 USALi Chong, The University of Sydney Department of Cancer Medicine, Faculty of Medicine Sydney NSW 2006 AustraliaXing-Cong Li, The University of Mississippi The National Center for Natural Products Research, School of Pharmacy University MS 38677 USAIkhlas A. Khan, The University of Mississippi The National Center for Natural ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3255801 Sat, 06 Feb 2010 18:00:08 +0100 3255801 http://www.medworm.com/index.php?rid=3255803&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn46x6014383j60l3%2F Conclusion  These results indicate that the systemic delivery of plasmid DNA targeting FAK function using cationic liposome as a gene carrier, represents a promising avenue for breast cancer therapy. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0773-3Authors An-liang Huang, Sichuan University State Key Laboratory of Biotherapy, West China Hospital Chengdu ChinaYang Wan, Sichuan University State Key Laboratory of Biotherapy, West China Hospital Chengdu ChinaDian-ying Liao, Sichuan University Department of Pathology, West China Hospital Chengdu ChinaHuo-zhen Hu, Sichuan University College of Life Science Chengdu ChinaLin Wei, Sichuan University State Key Laboratory of Biotherapy, West China Hospital Chengdu ChinaXian-huo Wang, Sichuan Universi... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3255803 Sat, 06 Feb 2010 18:00:05 +0100 3255803 http://www.medworm.com/index.php?rid=3255802&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx667303662113708%2F Conclusion  We could not confirm the presence of a specific methylation profile in disseminated neuroblastoma tumour cells, but a high accumulation of epigenetic events in those cells is associated with a high risk of relapse, independently of MYCN amplification. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0796-9Authors E. Grau, Hospital Universitario La Fe Unidad de Genética y Diagnóstico Prenatal, Edificio de Anatomia Patologica Av/Campanar Nº21 46009 Valencia SpainF. Martinez, Hospital Universitario La Fe Unidad de Genética y Diagnóstico Prenatal, Edificio de Anatomia Patologica Av/Campanar Nº21 46009 Valencia SpainC. Orellana, Hospital Universitario La Fe Unidad de Genética y Diagnóstico Prenatal, Edificio de Anatomia Patologica... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3255802 Sat, 06 Feb 2010 18:00:05 +0100 3255802 http://www.medworm.com/index.php?rid=3255805&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F61455n1572nt1130%2F Conclusion  Although the number of patients was limited in this study, TK1 in serum might possess an important reference value in the evaluation of treatment and prognosis of non-Hodgkin’s lymphoma following chemotherapy. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0769-zAuthors Zhu-Lin Pan, PLA Hospital Department No. 411 Shanghai 200081 ChinaXing-Ying Ji, PLA Hospital Department No. 411 Shanghai 200081 ChinaYan-Min Shi, Diba Wu Hospital Department No. 85 Shanghai 200052 ChinaJi Zhou, Sino-Swed Molecular Bio-Medicine Research Institute Shenzhen ChinaEllen He, Sino-Swed Molecular Bio-Medicine Research Institute Shenzhen ChinaSven Skog, Sino-Swed Molecular Bio-Medicine Research Institute Shenzhen China Journal Journal of Cancer Rese... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3255805 Sat, 06 Feb 2010 18:00:04 +0100 3255805 http://www.medworm.com/index.php?rid=3255804&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe62354541lv08713%2F Conclusions  Our results suggest that B7/CD28 family PBTs may serve as valuable markers reflecting the pathological features of colon cancer. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0800-4Authors Hyunji Lee, Inje University College of Medicine Department of Microbiology and Immunology, Bio-Marker Research Center for Personalized Therapy Busan 614-735 KoreaJi Hyun Kim, Inje University College of Medicine Division of Gastroenterology, Department of Internal Medicine Busan 614-735 KoreaSung Yeun Yang, Inje University College of Medicine Division of Gastroenterology, Department of Internal Medicine Busan 614-735 KoreaJihye Kong, Inje University College of Medicine Department of Microbiology and Immunology, Bio-Marker Research Center for Pers... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3255804 Sat, 06 Feb 2010 18:00:04 +0100 3255804 http://www.medworm.com/index.php?rid=3247886&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu2v5538280700948%2F Conclusion  This review examines data and strategies addressing an approach conquering chemoresistance through the combination of IGF-1R targeted therapy and chemotherapy in cancer patients, as well as the mechanisms by which IGF-1R acts as a target. This will impact on future research on treatment selection, thereby improving patient prognosis. Content Type Journal ArticleCategory ReviewDOI 10.1007/s00432-010-0792-0Authors Alyse Hopkins, Prince of Wales Hospital, University of New South Wales Surgical Oncology Research Group, Oncology Research Centre, Faculty of Medicine Level 2 Clinical Sciences Building, Randwick Sydney NSW 2031 AustraliaPhilip J. Crowe, Prince of Wales Hospital, University of New South Wales Department of Surgery, Faculty of Medicine Sydney NSW Aus... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3247886 Fri, 05 Feb 2010 17:53:37 +0100 3247886 http://www.medworm.com/index.php?rid=3247885&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu5k8k4q446308344%2F Conclusion  Colorectal cancer and colonic adenoma are rare in patients of Turkish descent living in the Zaanstreek region, the Netherlands. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0799-6Authors S. M. L. A. Loffeld, Zaans Medisch Centrum Department of Internal Medicine PO Box 210 1500 EE Zaandam The NetherlandsR. J. L. F. Loffeld, Zaans Medisch Centrum Department of Internal Medicine PO Box 210 1500 EE Zaandam The Netherlands Journal Journal of Cancer Research and Clinical OncologyOnline ISSN 1432-1335Print ISSN 0171-5216 (Source: Journal of Cancer Research and Clinical Oncology) Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3247885 Fri, 05 Feb 2010 17:53:37 +0100 3247885 http://www.medworm.com/index.php?rid=3247889&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fav23480374074lv2%2F Conclusion  In our study, the 399-Gln allele of XRCC1 increased significantly the risk of BC and it may act as a dominant allele [Arg/Arg vs. (Gln/Gln + Arg/Gln), OR = 4.67 (95% CI 1.65–13.23), p = 0.005]. The combination of variant alleles at codon 399 and in position −77 could affect XRCC1 protein activity, impairing genome integrity and promoting cancer occurrence. Also, the number of SNPs in several genes involved in BER and HRR mechanisms made higher the risk of sporadic BC. We can conclude that genetic variants in multiple repair pathways may have a joint or additive effect in cancer risk. Content Type Journal ArticleCategory Rapid CommunicationDOI 10.1007/s00432-010-0791-1Authors Silvia Sterpone, Rome Tre University Department... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3247889 Fri, 05 Feb 2010 17:53:36 +0100 3247889 http://www.medworm.com/index.php?rid=3247888&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj50735404n22x4pv%2F Conclusion  GRP is a multi-functional peptide, which acts as a stress mediator as well as a growth factor linking stressor to cancer progression. GRP and its high-affinity receptor are useful targets for the diagnosis and treatment of cancers. Content Type Journal ArticleCategory ReviewDOI 10.1007/s00432-010-0766-2Authors Xinqiu Li, First Affiliated Hospital of Xi’an Jiaotong University Department of Hepatobiliary Surgery 277, West Yanta Road 710061 Xi’an People’s Republic of ChinaYunfu Lv, The People’s Hospital of Hainan Province Department of General Surgery Haikou People’s Republic of ChinaAihua Yuan, First Affiliated Hospital of Xi’an Jiaotong University Department of Hepatobiliary Surgery 277, West Yanta Road 710061 Xi’an People’s Republic of ChinaZ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3247888 Fri, 05 Feb 2010 17:53:36 +0100 3247888 http://www.medworm.com/index.php?rid=3247887&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft313l5x0061611t0%2F Conclusions  These results strongly suggest that PRL-3 expression can indicate the potential role of LNM to some extent. Increasing the risk of tumor metastasis (OR = 3.889). Our results also imply that PRL-3 might be a novel molecular marker for predicting relapse of invasive breast cancer. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0786-yAuthors Ru-Tian Hao, The First Affiliated Hospital of Wenzhou Medical College Department of Surgical Oncology Wenzhou 325000 ChinaXiao-Hua Zhang, The First Affiliated Hospital of Wenzhou Medical College Department of Surgical Oncology Wenzhou 325000 ChinaYi-Fei Pan, The First Affiliated Hospital of Wenzhou Medical College Department of Surgical Oncology Wenzhou 325000 ChinaHai-Guang Liu, The F... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3247887 Fri, 05 Feb 2010 17:53:36 +0100 3247887 http://www.medworm.com/index.php?rid=3247890&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr472121858082060%2F Conclusions  These results indicated that PA28β might participate in the origin and progression of GA cancer through changes to cell proliferation activity and tumorigenicity. Therefore, PA28β might be a novel biomarker for GA. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0778-yAuthors Qiaojia Huang, Fujian Medical University Key Laboratory of Infection and Oncology, Research Center of Molecular Medicine 88 Jiaotong Road Fuzhou 350004 People’s Republic of ChinaQingling Huang, Fujian Medical University Key Laboratory of Infection and Oncology, Research Center of Molecular Medicine 88 Jiaotong Road Fuzhou 350004 People’s Republic of ChinaWansong Lin, Fujian Medical University Key Laboratory of Infection and Oncology, Research Center of M... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3247890 Fri, 05 Feb 2010 17:53:35 +0100 3247890 http://www.medworm.com/index.php?rid=3247891&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl14n388123pm76xk%2F Conclusions  External beam radiotherapy seems to improve the prognosis of patients with resected intrahepatic cholangiocarcinoma and concurrent macroscopic lymph node metastases. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0783-1Authors Wei Jiang, Fudan University Department of Radiation Oncology, Zhongshan Hospital 136 Yi Xue Yuan Road Shanghai 200032 ChinaZhao-Chong Zeng, Fudan University Department of Radiation Oncology, Zhongshan Hospital 136 Yi Xue Yuan Road Shanghai 200032 ChinaZhao-You Tang, Fudan University Liver Cancer Institute, Zhongshan Hospital Shanghai 200032 ChinaJia Fan, Fudan University Liver Cancer Institute, Zhongshan Hospital Shanghai 200032 ChinaJian Zhou, Fudan University Liver Cancer Institute, Zhongshan Hospital Shan... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3247891 Thu, 04 Feb 2010 06:44:59 +0100 3247891 http://www.medworm.com/index.php?rid=3240873&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa20249676m3xr780%2F Conclusion  cICAT combined with LC-MS/MS-based serum proteome analysis can be useful in the screening of serum biomarkers for HCC. Alpha-1-acid glycoprotein combining AFP could aid the diagnosis of HCC. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0762-6Authors Xiaonan Kang, Zhongshan Hospital Liver cancer Institute Shanghai 200032 People’s Republic of ChinaLu Sun, Zhongshan Hospital Liver cancer Institute Shanghai 200032 People’s Republic of ChinaKun Guo, Zhongshan Hospital Liver cancer Institute Shanghai 200032 People’s Republic of ChinaHong Shu, Zhongshan Hospital Liver cancer Institute Shanghai 200032 People’s Republic of ChinaJun Yao, Fudan University Center for Proteomics Research, Institute of Biomedical Sciences Shanghai 2000... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3240873 Wed, 03 Feb 2010 17:55:59 +0100 3240873 http://www.medworm.com/index.php?rid=3240872&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj937j6t136478045%2F Conclusion  The comprehensive values of DVH parameters, chemotherapy, and gender have independent effects on the occurrence of RP. Most of DVH parameters were associated with the occurrence of RP. The curve shape composed of multiple points in DVH parameters was more important than any single DVH parameter. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0764-4Authors Jun Dang, The First Affiliated Hospital of China Medical University Department of Radiation Oncology 110001 Shenyang ChinaGuang Li, The First Affiliated Hospital of China Medical University Department of Radiation Oncology 110001 Shenyang ChinaXiaobe Lu, The First Affiliated Hospital of China Medical University Department of Radiation Oncology 110001 Shenyang ChinaLei Yao, The Fi... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3240872 Wed, 03 Feb 2010 17:55:59 +0100 3240872 http://www.medworm.com/index.php?rid=3240874&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh288xn480x300470%2F Conclusion  Rh-endostatin could normalize the tumor vasculature and microenvironment in Lewis lung carcinoma probably via modulation of the balance between vascular endothelial growth factor-A and thrombospondin-1. During the time of vascular normalization, paclitaxel treatment was found to have maximal effect on tumor growth delay. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0770-6Authors Guichun Huang, Medical School of Nanjing University Medical Oncology Department of Jinling Hospital 305 ZhongShan Eastern Road Nanjing 210002 People’s Republic of ChinaLongbang Chen, Medical School of Nanjing University Medical Oncology Department of Jinling Hospital 305 ZhongShan Eastern Road Nanjing 210002 People’s Republic of China Journal ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3240874 Wed, 03 Feb 2010 17:55:58 +0100 3240874 http://www.medworm.com/index.php?rid=3240875&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9071p23k86123116%2F Conclusions  HCA is a very good marker for tumors, especially for HCC. It could play important roles in HCC development and progression and can be a promising molecular target for the development of new diagnostic and therapeutic strategies for HCC. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0767-1Authors Yan Liu, Central South University Tumor Immunobiology Laboratory of Cancer Research Institute 410078 Changsha Hunan ChinaYuehui Li, Central South University Tumor Immunobiology Laboratory of Cancer Research Institute 410078 Changsha Hunan ChinaFengjie Guo, Central South University Tumor Immunobiology Laboratory of Cancer Research Institute 410078 Changsha Hunan ChinaMiao Dai, Affiliated Hospital of Weifang School of Medicine 261031 Weifan... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3240875 Wed, 03 Feb 2010 17:55:57 +0100 3240875 http://www.medworm.com/index.php?rid=3240876&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg3l236g061072516%2F Conclusions  The misdiagnosed patients had relatively poor prognosis, but the effect of misdiagnosis on the prognosis was not significant; however, misdiagnosis of AMM as hemorrhoids seriously affected the prognosis. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0793-zAuthors Sen Zhang, The First Affiliated Hospital of Guangxi Medical University Colorectal Surgery 6 Shuangyong Road Nanning 530021 ChinaFeng Gao, The First Affiliated Hospital of Guangxi Medical University Colorectal Surgery 6 Shuangyong Road Nanning 530021 ChinaDesen Wan, Tumor Hospital of Sun Yat-sen University Department of Abdominal Surgery Guangzhou 510060 China Journal Journal of Cancer Research and Clinical OncologyOnline ISSN 1432-1335Print ISSN 0171-5216 (Source:... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3240876 Wed, 03 Feb 2010 17:55:55 +0100 3240876 http://www.medworm.com/index.php?rid=3240877&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv7160t47nr18mw21%2F Conclusions  There are significant differences in the expression of MMPs and TIMPs, so in tumor cells and stromal cells, between pure DCIS and DCIS with microinvasive foci. Therefore, these staining patterns might display potential applications as biological markers, such as in evaluating microinvasion in resection specimens of breast tumors. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0782-2Authors L. O. González, Unidad de Investigación, Hospital de Jove Avda. Eduardo Castro s/n 33920 Gijón Asturias SpainS. González-Reyes, Unidad de Investigación, Hospital de Jove Avda. Eduardo Castro s/n 33920 Gijón Asturias SpainS. Junquera, Unidad de Investigación, Hospital de Jove Avda. Eduardo Castro s/n 33920 Gijón Asturias SpainL. Marín, ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3240877 Tue, 02 Feb 2010 17:48:18 +0100 3240877 http://www.medworm.com/index.php?rid=3240878&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc13133237jp166m4%2F Conclusions  CD44v6 might be correlated with histogenesis of NSCLC, and its decreased expression may be an adverse prognostic indicator for the patients with stage I NSCLC, especially for those with stage IB diseases. Patients of this subgroup might need adjuvant therapy additionally. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0771-5Authors Dongrong Situ, Sun Yat-sen University Department of Thoracic Surgery Cancer Center 651, Dongfeng Road East 510060 Guangzhou People’s Republic of ChinaHao Long, Sun Yat-sen University Department of Thoracic Surgery Cancer Center 651, Dongfeng Road East 510060 Guangzhou People’s Republic of ChinaPeng Lin, Sun Yat-sen University Department of Thoracic Surgery Cancer Center 651, Dongfeng Road East 5100... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3240878 Tue, 02 Feb 2010 17:48:17 +0100 3240878 http://www.medworm.com/index.php?rid=3240879&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ful672kh0030x12hj%2F Conclusions  rBCG-MVNTR4-CSF and rBCG-MVNTR8-CSF vaccines may be good candidates for breast tumor immunotherapy. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0787-xAuthors Shifang Yuan, Xijing Hospital, Fourth Military Medical University Department of Vascular and Endocrine Surgery 17 Changle West Road Xi’an 710033 People’s Republic of ChinaChanghong Shi, Laboratory Animal Research Center of the Fourth Military Medical University 17 Changle West Road Xi’an 710033 People’s Republic of ChinaRui Ling, Xijing Hospital, Fourth Military Medical University Department of Vascular and Endocrine Surgery 17 Changle West Road Xi’an 710033 People’s Republic of ChinaTing Wang, Xijing Hospital, Fourth Military Medical University Department of Va... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3240879 Tue, 02 Feb 2010 17:48:16 +0100 3240879 http://www.medworm.com/index.php?rid=3240880&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu220277006n11073%2F Conclusions  These results suggest that FAK may serve as a marker of cervical lymph node metastasis of tongue cancer and that RNAi targeting FAK could serve as a potential therapeutic for the treatment of tongue cancer. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0780-4Authors Hongbing Jiang, Nanjing Medical University Department of Oral and Maxillofacial Surgery, School of Stomatology Nanjing 210029 Jiangsu People’s Republic of ChinaLaikui Liu, Nanjing Medical University Department of Oral Pathology, School of Stomatology Nanjing 210029 Jiangsu People’s Republic of ChinaJinhai Ye, Nanjing Medical University Department of Oral and Maxillofacial Surgery, School of Stomatology Nanjing 210029 Jiangsu People’s Republic of ChinaHualian Liu... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3240880 Tue, 02 Feb 2010 06:58:20 +0100 3240880 http://www.medworm.com/index.php?rid=3232734&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk31r432747414887%2F Conclusions  Our results suggest that the over-expression of telomeric proteins, TRF1, TRF2, TIN2, TERT, and Ku70, and the transposition of the BRCA1 protein may work together to reduce the telomere length in precancerous lesions and gastric cancer, and could contribute to the multistage carcinogenesis of gastric cancer. These findings offer new insight into the mechanism of carcinogenesis in gastric cancer. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0795-xAuthors Hua Hu, University of South China Cancer Research Institute, The Second Affiliated Hospital 421001 Hengyang Hunan People’s Republic of ChinaYang Zhang, University of South China Cancer Research Institute 421001 Hengyang Hunan People’s Republic of ChinaMei Zou, University of... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3232734 Mon, 01 Feb 2010 18:02:58 +0100 3232734 http://www.medworm.com/index.php?rid=3232735&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft52l4v51r8606373%2F Conclusion  Despite this finding p21 does not appear to act as an exclusive prognostic marker for breast cancer disease. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0788-9Authors Florian Ebner, I Frauenklinik der Ludwig-Maximilians-Universität München Maistrasse 11 80337 Munich GermanyElisabeth Schremmer-Danninger, Technical University Munich Department of Surgery and Policlinic, Klinikum rechts der Isar Ismaninger Strasse 22 81675 Munich GermanyJoachim Rehbock, I Frauenklinik der Ludwig-Maximilians-Universität München Maistrasse 11 80337 Munich Germany Journal Journal of Cancer Research and Clinical OncologyOnline ISSN 1432-1335Print ISSN 0171-5216 (Source: Journal of Cancer Research and Clinical Oncology) Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3232735 Mon, 01 Feb 2010 18:02:56 +0100 3232735 http://www.medworm.com/index.php?rid=3232736&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj243063305581n6j%2F Conclusions  Our findings demonstrate that EGCG is effective for growth inhibition of a chondrosarcoma cell lines in vitro, and suggest that EGCG may be a new therapeutic option for patients with chondrosarcoma. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0765-3Authors Guo-Qing Tang, Peking University People’s Hospital Musculoskeletal Tumor Center No. 11 Xizhimen South Street 100044 Beijing ChinaTai-Qiang Yan, Peking University People’s Hospital Musculoskeletal Tumor Center No. 11 Xizhimen South Street 100044 Beijing ChinaWei Guo, Peking University People’s Hospital Musculoskeletal Tumor Center No. 11 Xizhimen South Street 100044 Beijing ChinaTing-Ting Ren, Peking University People’s Hospital Musculoskeletal Tumor Center No. 11 Xizh... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3232736 Mon, 01 Feb 2010 18:02:55 +0100 3232736 http://www.medworm.com/index.php?rid=3228475&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp370h3wn4287j41h%2F Conclusions   WIF-1 silencing as a result of its promoter hypermethylation may be a frequent event in HCC. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0763-5Authors Yun Deng, Shanghai Jiao Tong University School of Medicine State Key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute 200032 Shanghai ChinaBin Yu, Shanghai Jiao Tong University School of Medicine State Key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute 200032 Shanghai ChinaQin Cheng, Shanghai Jiao Tong University School of Medicine State Key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute 200032 Shanghai ChinaJie Jin, Jiangsu University Institute of Life Sciences 212013 Zhenjiang ChinaHaiyan You, Shanghai Jiao Ton... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3228475 Fri, 29 Jan 2010 17:58:54 +0100 3228475 http://www.medworm.com/index.php?rid=3228476&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb44126l1u5m02222%2F Content Type Journal ArticleCategory Retraction NoteDOI 10.1007/s00432-010-0768-0Authors Xiao-Chun Wang, Chinese Academy of Medical Science Institute of Radiation Medicine 300192 Tianjin ChinaLi-Li Tian, Chinese Academy of Medical Science Institute of Radiation Medicine 300192 Tianjin ChinaJing Tian, Cancer Prevention and Treatment Institute of Shandong Province Department of 4th Internal Medicine 250117 Jinan Shandong ChinaHai-Liang Wu, Shandong Provincial Chest Hospital Department of Tumor Medicine 250013 Jinan ChinaAi-min Meng, Chinese Academy of Medical Science Institute of Radiation Medicine 300192 Tianjin China Journal Journal of Cancer Research and Clinical OncologyOnline ISSN 1432-1335Print ISSN 0171-5216 (Source: Journal of Cancer Research and Clinical Oncology) Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3228476 Fri, 29 Jan 2010 12:15:33 +0100 3228476 http://www.medworm.com/index.php?rid=3223934&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn7g5531p34pg1708%2F Conclusions  In summary, application of HRM analysis to large amount of clinical samples proves to be a fast and high-throughput way to investigate the epigenetic status of GADD45G. And this is the first study to evaluate the prevalence of GADD45G methylation based on large amount of tumor samples, showing that epigenetic regulation of GADD45G was associated with carcinogenesis. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0777-zAuthors Wei Zhang, Jinan University JNU-HKUST Joint Lab Guangdong ChinaTianrun Li, Peking University Third Hospital Department of Intervention and Vascular Surgery Beijing ChinaYong Shao, Shenzhen Hospital Peking University Department of Dermatology No. 1120, Lian-Hua Road, Fu-Tian District Shenzhen Guangdong ChinaC... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3223934 Thu, 28 Jan 2010 18:00:01 +0100 3223934 http://www.medworm.com/index.php?rid=3205684&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr060147843775452%2F Conclusion  The MGMT −535G>T polymorphism (rs1625649) was found to be correlated with PFS in patients with advanced colorectal cancer treated with oxaliplatin-based chemotherapy. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0760-8Authors Jee Hyun Park, Kyungpook National University Hospital, Kyungpook National University School of Medicine Department of Internal Medicine Daegu KoreaNung Soo Kim, Kyungpook National University Hospital, Kyungpook National University School of Medicine Department of Internal Medicine Daegu KoreaJae Yong Park, Kyungpook National University Hospital, Kyungpook National University School of Medicine Department of Internal Medicine Daegu KoreaYee Soo Chae, Kyungpook National University Hospital, Kyungpook Nati... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3205684 Fri, 22 Jan 2010 03:00:59 +0100 3205684 http://www.medworm.com/index.php?rid=3205686&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq641721r2p05p084%2F Conclusion  In conclusion, MRI seemed to be a more useful supplement to current surveillance techniques to assess patients with suspected recurrent and/or metastatic breast cancer. If MRI shows an indeterminate or benign lesion or MRI was not applicable, FDG-PET could be performed in addition. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0746-6Authors LingLing Pan, Chinese Academy of Sciences 730000 Lanzhou ChinaYuan Han, Chinese Academy of Sciences 730000 Lanzhou ChinaXiaoGuang Sun, Chinese Academy of Sciences 730000 Lanzhou ChinaJianJun Liu, Chinese Academy of Sciences 730000 Lanzhou ChinaHuang Gang, Chinese Academy of Sciences 730000 Lanzhou China Journal Journal of Cancer Research and Clinical OncologyOnline ISSN 1432-1335Print I... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3205686 Fri, 22 Jan 2010 03:00:58 +0100 3205686 http://www.medworm.com/index.php?rid=3205685&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F181r825666n8684p%2F Conclusion   18F-FDG-PET/CT is a useful tool in detecting second primary malignancies in an early stage and can improve the therapeutic effects experienced by the patients. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0759-1Authors Haoping Xu, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine Department of Nuclear Medicine No. 197, Rui Jin Er Road 200025 Shanghai People’s Republic of ChinaMiao Zhang, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine Department of Nuclear Medicine No. 197, Rui Jin Er Road 200025 Shanghai People’s Republic of ChinaGe Zhai, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine Department of Nuclear Medicine No. 197, Rui Jin Er Road 200025 Shanghai People’s R... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3205685 Fri, 22 Jan 2010 03:00:58 +0100 3205685 http://www.medworm.com/index.php?rid=3194910&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw8j152507n1qp053%2F Conclusions  PTEN-deficient endometrial cancer cells exhibit higher p38MAPK activity, and genetic studies demonstrate that p38MAPK functions dependently of AKT. Furthermore, PTEN loss sensitizes cells to p38MAPK inhibition in endometrial carcinoma cells. These findings indicate that inhibitors of p38MAPK have the potential to be effective in the treatment of endometrial cancer patients with PTEN-deficient tumors and should be evaluated in this setting. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0756-4Authors Lan Xiao, Sun Yat-sen University Department of Obstetrics and Gynecology, The Third Affiliated Hospital 600 TianHe Road 510630 Guangzhou People’s Republic of ChinaYue-bo Yang, Sun Yat-sen University Department of Obstetrics and Gyn... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3194910 Tue, 19 Jan 2010 17:42:14 +0100 3194910 http://www.medworm.com/index.php?rid=3190396&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh446261h56873k50%2F Conclusions  The use of a panel of plasma biomarkers for the identification of women with ovarian cancer delivers a significant increase in diagnostic performance when compared to the performance of CA-125 alone. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0755-5Authors Tracey Edgell, HealthLinx Limited 576 Swan Street Richmond VIC 3121 AustraliaG. Martin-Roussety, HealthLinx Limited 576 Swan Street Richmond VIC 3121 AustraliaG. Barker, Baker Medical Research Institute Melbourne 3004 AustraliaD. J. Autelitano, HealthLinx Limited 576 Swan Street Richmond VIC 3121 AustraliaD. Allen, University of Melbourne Department of Obstetrics and Gynaecology Melbourne AustraliaP. Grant, University of Melbourne Department of Obstetrics and Gynaecology Mel... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3190396 Fri, 15 Jan 2010 17:59:22 +0100 3190396 http://www.medworm.com/index.php?rid=3168476&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff7458137v1764q43%2F Conclusion  We conclude that Methyl-ALA-PDT could be an effective treatment in ovarian cancer and should be tested to apply intraperitoneally disseminated micro-foci during surgery. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0761-7Authors M. Wakui, Hirosaki University Graduate School of Medicine Department of Obstetrics and Gynecology 5 Zaifu-cho, Hirosaki Aomori 036-8562 JapanYoshihito Yokoyama, Hirosaki University Graduate School of Medicine Department of Obstetrics and Gynecology 5 Zaifu-cho, Hirosaki Aomori 036-8562 JapanH. Wang, Hirosaki University Graduate School of Medicine Department of Obstetrics and Gynecology 5 Zaifu-cho, Hirosaki Aomori 036-8562 JapanT. Shigeto, Hirosaki University Graduate School of Medicine Department of Obst... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3168476 Tue, 12 Jan 2010 18:18:28 +0100 3168476 http://www.medworm.com/index.php?rid=3168475&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp651vh2gr16p2231%2F Conclusions  We suggest that the investigation of multiple gene polymorphisms, versus single genes, could contribute to a better understanding of the effect of susceptibility genes on cancer risk. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0757-3Authors Selena Palma, C.R. ENEA Casaccia Section Toxicology and Biomedical Sciences Via Anguillarese 301 00123 Rome ItalyFlavia Novelli, C.R. ENEA Casaccia Section Toxicology and Biomedical Sciences Via Anguillarese 301 00123 Rome ItalyLuca Padua, Don Carlo Gnocchi Foundation Rome ItalyAldo Venuti, Regina Elena Cancer Institute Virology Laboratory Rome ItalyGrazia Prignano, IRCCS San Gallicano Institute SSO Immunology Diagnostic Rome ItalyLuciano Mariani, Regina Elena Cancer Institute Gynecologic O... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3168475 Tue, 12 Jan 2010 18:18:28 +0100 3168475 http://www.medworm.com/index.php?rid=3160624&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm553u66747302818%2F Abstract  Cigarette smoking is the predominant risk factor for bladder cancer in males and females. The tobacco carcinogens are metabolized by various xenobiotic metabolizing enzymes such as N-acetyltransferases (NAT) and glutathione S-transferases (GST). Polymorphisms in NAT and GST genes alter the ability of these enzymes to metabolize carcinogens. In this paper, we conduct a statistical analysis based on logistic regressions to assess the impact of smoking and metabolizing enzyme genotypes on the risk to develop bladder cancer using a case–control study from Tunisia. We also use the generalized ordered logistic model to investigate whether these factors do have an impact on the progression of bladder tumors. Content Type Journal ArticleCategory Original PaperDOI 10.10... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3160624 Fri, 08 Jan 2010 21:37:35 +0100 3160624 http://www.medworm.com/index.php?rid=3154189&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fqr357733k7645k04%2F Conclusions  The histopathologic RS can serve to identify a subgroup of patients <60 years who have a high recurrence rate of oral tongue cancer, irrespective of the margin status. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0749-3Authors Marilena Vered, Tel Aviv University Department of Oral Pathology and Oral Medicine, School of Dental Medicine 69978 Tel Aviv IsraelDan Dayan, Tel Aviv University Department of Oral Pathology and Oral Medicine, School of Dental Medicine 69978 Tel Aviv IsraelAlex Dobriyan, The Chaim Sheba Medical Center Department of Oral and Maxillofacial Surgery Tel Hashomer IsraelRan Yahalom, The Chaim Sheba Medical Center Department of Oral and Maxillofacial Surgery Tel Hashomer IsraelBruria Shalmon, The Chaim Sh... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3154189 Wed, 06 Jan 2010 18:04:51 +0100 3154189 http://www.medworm.com/index.php?rid=3154190&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F820573205p171565%2F Conclusion  Our data shows that CRBP-1 gene gain can be determined by immunohistochemistry on routinely processed tissue specimens, and could support as a potential novel marker for long-term survival in laryngeal squamous cell carcinoma. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0735-9Authors Raúl Peralta, IMSS Oncology Research Unit, Hospital Oncologia, Health Research Coordination Mexico City MexicoMichael Baudis, Institute of Molecular Biology, University of Zurich Zurich SwitzerlandGuelaguetza Vazquez, IMSS Oncology Research Unit, Hospital Oncologia, Health Research Coordination Mexico City MexicoSergio Juárez, IMSS Oncology Research Unit, Hospital Oncologia, Health Research Coordination Mexico City MexicoRocío Ortiz, Hospital CIM... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3154190 Wed, 06 Jan 2010 18:04:50 +0100 3154190 http://www.medworm.com/index.php?rid=3154191&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F508742310l843421%2F Conclusion  In this cohort of patients, HER2 positivity indicated higher rates of local and distant recurrence. In contrast, TopIIa IHC positivity predicted lower risk of metastases and death, thus being a positive-predictive factor for the responsiveness to AbCTX. TopIIa gene amplification did not add predictive information. Therefore, we conclude that TopIIa protein expression might rather be the target of anthracyclines independent from gene copy number. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0748-4Authors Christian Schindlbeck, Ludwig-Maximilians-University Department of Obstetrics and Gynecology, Campus Innenstadt Maistrasse 11 80337 Munich GermanyD. Mayr, Ludwig-Maximilians-University Institute of Pathology Thalkirchnerstrasse ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3154191 Tue, 05 Jan 2010 16:58:36 +0100 3154191 http://www.medworm.com/index.php?rid=3154192&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fln6t8g7771485262%2F Conclusions  VEGF is directly regulated by constitutive STAT3 activity and associated with meningioma differentiation. STAT3 has an important role in the occurrence and development of human meningioma by regulating VEGF expression. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0743-9Authors Mao Xiu Zhang, Shandong University School of Medicine Department of Microbiology 44#, Wenhua Xi Road 250012 Jinan Shandong People’s Republic of ChinaXu Zhao, The Second Hospital of Shandong University Department of Neurosurgery 247#, Beiyuan Road 250033 Jinan Shandong People’s Republic of ChinaZhi Gang Wang, The Second Hospital of Shandong University Department of Neurosurgery 247#, Beiyuan Road 250033 Jinan Shandong People’s Republic of ChinaWei Min... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3154192 Tue, 05 Jan 2010 16:58:34 +0100 3154192 http://www.medworm.com/index.php?rid=3154193&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fnrm1578618ujr47x%2F Conclusions  All the results indicate that nucleolin acts as a receptor for Tipα and shuttles Tipα from cell surface to cytosol and nuclei. These findings provide a new mechanistic insight into gastric cancer development with Tipα. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0733-yAuthors Tatsuro Watanabe, Saitama Cancer Center, Research Institute for Clinical Oncology Kitaadachi-gun Saitama 362-0806 JapanHideaki Tsuge, Tokushima Bunri University Institute for Health Sciences Tokushima 770-8514 JapanTakahito Imagawa, Tokushima Bunri University Institute for Health Sciences Tokushima 770-8514 JapanDaisuke Kise, Tokushima Bunri University Faculty of Pharmaceutical Sciences Tokushima 770-8514 JapanKazuya Hirano, Tokyo University of Pharmacy... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3154193 Tue, 05 Jan 2010 06:46:19 +0100 3154193 http://www.medworm.com/index.php?rid=3136182&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv747n87370098858%2F Conclusions  None of the 40 miRNA-related gene polymorphisms investigated in this study was found to be an independent prognostic marker for Korean patients with surgically resected colorectal cancer. However, further studies are warranted to clarify the role of miRNA-related gene polymorphisms as a prognostic biomarker for colorectal cancer patients. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0754-6Authors Hyun-Chul Lee, Kyungpook National University School of Medicine Advanced Medical Technology Cluster Center, Kyungpook National University Hospital Daegu KoreaJong Gwang Kim, Kyungpook National University School of Medicine Department of Oncology/Hematology, Kyungpook National University Hospital 50 Samduck 2-Ga, Jung-Gu Daegu 700-712 K... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3136182 Thu, 31 Dec 2009 16:45:11 +0100 3136182 http://www.medworm.com/index.php?rid=3134317&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl636x83g78623170%2F Conclusions  Novel additional mutations of KIT gene exon 13 or exon 17 indicate the likely mechanism of secondary resistance to imatinib. The PI3-K/AKT pathway might be more relevant than MEK/MAPK for therapeutic targeting in imatinib-resistant GIST patients with secondary mutation. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0753-7Authors Chun-Meng Wang, Fudan University Abdominal Department, Cancer Hospital 270 Dong’an Road 200032 Shanghai People’s Republic of ChinaKai Huang, Fudan University Abdominal Department, Cancer Hospital 270 Dong’an Road 200032 Shanghai People’s Republic of ChinaYe Zhou, Fudan University Abdominal Department, Cancer Hospital 270 Dong’an Road 200032 Shanghai People’s Republic of ChinaChun-Yan Du, Fudan... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3134317 Wed, 30 Dec 2009 16:44:54 +0100 3134317 http://www.medworm.com/index.php?rid=3130559&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg36hk17556536616%2F Conclusions  Our data indicate differences in MMPs/TIMPs expression between primary tumors of patients with LRs and of those with distant metastasis, both after mastectomy for breast cancer. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0750-xAuthors José M. del Casar, Unidad de Investigación, Fundación Hospital de Jove Gijon SpainGuillermo Carreño, Servicio de Cirugía General, Hospital de Cabueñes Gijon SpainLuis O. González, Unidad de Investigación, Fundación Hospital de Jove Gijon SpainSara Junquera, Unidad de Investigación, Fundación Hospital de Jove Gijon SpainSalomé González-Reyes, Unidad de Investigación, Fundación Hospital de Jove Gijon SpainJosé M. González, Unidad de Investigación, Fundación Hospital de Jove Gijon... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3130559 Tue, 29 Dec 2009 17:56:42 +0100 3130559 http://www.medworm.com/index.php?rid=3125032&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu471654m25xm34rw%2F Conclusion  PFS-1 is one of the prognostic factors of Cx-2 in patients with AGC. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0752-8Authors Kenji Hashimoto, National Cancer Center Hospital Gastrointestinal Oncology Division 5-1-1, Tsukiji Chuuou-ku Tokyo 104-0045 JapanAtsuo Takashima, National Cancer Center Hospital Gastrointestinal Oncology Division 5-1-1, Tsukiji Chuuou-ku Tokyo 104-0045 JapanKengo Nagashima, Josai University Faculty of Pharmaceutical Sciences 1-1 Keyakidai Sakado Saitama 350-0295 JapanShun-suke Okazaki, National Cancer Center Hospital Gastrointestinal Oncology Division 5-1-1, Tsukiji Chuuou-ku Tokyo 104-0045 JapanTakako Eguchi Nakajima, National Cancer Center Hospital Gastrointestinal Oncology Division 5-1-1, Tsukiji Chuuo... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3125032 Sat, 26 Dec 2009 16:38:43 +0100 3125032 http://www.medworm.com/index.php?rid=3122735&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff0h7062136731587%2F Conclusion  Here we have gathered information is known about biological activities of FHIT, the structural and biochemical bases for their functions. Our approach may provide a comparative framework for further investigation of FHIT. Content Type Journal ArticleCategory ReviewDOI 10.1007/s00432-009-0751-9Authors Md. Imtaiyaz Hassan, Jamia Millia Islamia Centre for Interdisciplinary Research in Basic Sciences Jamia Nagar New Delhi 110025 IndiaAbdullah Naiyer, Jamia Millia Islamia Centre for Interdisciplinary Research in Basic Sciences Jamia Nagar New Delhi 110025 IndiaFaizan Ahmad, Jamia Millia Islamia Centre for Interdisciplinary Research in Basic Sciences Jamia Nagar New Delhi 110025 India Journal Journal of Cancer Research and Clinical OncologyOnline ISSN 1432-... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3122735 Thu, 24 Dec 2009 19:56:51 +0100 3122735 http://www.medworm.com/index.php?rid=3116366&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6383t531561t8742%2F Conclusion  Overexpression of let-7a can inhibit the growth of lung cancer transplanted subcutaneously in nude mice by suppression of k-Ras and c-Myc. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0747-5Authors Xiao-yan He, Chongqing Medical University Department of Cell Biology and Medical Genetics, Molecular Medicine and Cancer Research Center No. 1, Medical College Road 400016 Chongqing ChinaJun-xia Chen, Chongqing Medical University Department of Cell Biology and Medical Genetics, Molecular Medicine and Cancer Research Center No. 1, Medical College Road 400016 Chongqing ChinaZheng Zhang, Chongqing Medical University Department of Cell Biology and Medical Genetics, Molecular Medicine and Cancer Research Center No. 1, Medical College Road 4... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3116366 Mon, 21 Dec 2009 23:00:04 +0100 3116366 http://www.medworm.com/index.php?rid=3108993&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F131547w4667j5053%2F Conclusions  The expressions of bHLH gene HES1 and HES5 are increased in advanced ovarian serous adenocarcinomas, and HES1 high-expression probably is a potential poor prognostic factor for the patients. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0744-8Authors Xinyu Wang, Zhejiang University Women’s Reproductive Health Laboratory of Zhejiang Province, Department of Gynecologic Oncology, Women’s Hospital, School of Medicine 310006 Hangzhou ChinaYajuan Fu, Zhejiang University Women’s Reproductive Health Laboratory of Zhejiang Province, Department of Gynecologic Oncology, Women’s Hospital, School of Medicine 310006 Hangzhou ChinaXiaoduan Chen, Zhejiang University Women’s Reproductive Health Laboratory of Zhejiang Province, Departmen... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3108993 Sat, 19 Dec 2009 16:44:00 +0100 3108993 http://www.medworm.com/index.php?rid=3105938&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb3j586807803lm51%2F Conclusions  We have shown that expression of Bmi-1 was elevated in colon cancer and might serve as an independent prognostic marker. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0745-7Authors Da-wei Li, Shanghai Jiaotong University Affiliated with First People’s Hospital Department of General Surgery Shanghai People’s Republic of ChinaHua-mei Tang, Shanghai Jiaotong University Affiliated with First People’s Hospital Department of Pathology Shanghai People’s Republic of ChinaJun-wei Fan, Shanghai Jiaotong University Affiliated with First People’s Hospital Department of General Surgery Shanghai People’s Republic of ChinaDong-wang Yan, Shanghai Jiaotong University Affiliated with First People’s Hospital Department of General Surge... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3105938 Fri, 18 Dec 2009 16:38:37 +0100 3105938 http://www.medworm.com/index.php?rid=3090175&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0l45221404604582%2F Conclusions  Complete resection of metastases represents a valid option in management of patients with relapsing or metastatic papillary RCC. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0732-zAuthors Thomas Steiner, University Hospital Jena Department of Urology Lessingstr. 1 07743 Jena GermanyHartmut Kirchner, Siloah Hospital Department of Internal Medicine Rosebeckstr. 15 30449 Hannover GermanyMichael Siebels, Josef-Retzer-Str. 48 81241 Munich GermanyChristian Doehn, University Hospital Luebeck Department of Urology Ratzeburger Allee 160 24538 Luebeck GermanyHans Heynemann, University Hospital Halle Department of Urology Ernst-Grube-Str. 40 06120 Halle GermanyZoltan Varga, Hospital Sigmaringen Department of Urology Hohenzollernstr. 40 724... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3090175 Sat, 12 Dec 2009 14:17:03 +0100 3090175 http://www.medworm.com/index.php?rid=3090176&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Funjk5055k24778g4%2F Conclusions  The results presented suggest that miRNA for silencing SOD2 radiosensitizing gene therapy maybe applicable to the nasopharyngeal carcinoma, improving the therapeutic ratio of cancer radiotherapy. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0739-5Authors Yaming Qu, Central South University Department of Otolaryngology Head and Neck Surgery, Xiang Ya Hospital 410008 Changsha ChinaSuping Zhao, Central South University Department of Otolaryngology Head and Neck Surgery, Xiang Ya Hospital 410008 Changsha ChinaJidong Hong, Central South University Department of Radiation Oncology, Xiang Ya Hospital 410008 Changsha ChinaSane Tang, Central South University Central Laboratory of Medical Research, Xiang Ya Hospital 410008 Changsha China ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3090176 Fri, 11 Dec 2009 06:52:34 +0100 3090176 http://www.medworm.com/index.php?rid=3090177&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx66q8t7812713214%2F Conclusions  This meta-analysis suggests that the Ala allele of the MnSOD gene was a low-penetrance susceptible gene in PCA development, especially in Caucasians. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0742-xAuthors Chen Mao, Southern Medical University Department of Epidemiology, School of Public Health and Tropical Medicine Guangzhou ChinaLi-Xin Qiu, Fudan University Department of Medical Oncology, Cancer Hospital 270 Dong An Road 200032 Shanghai People’s Republic of ChinaPing Zhan, Nanjing Chest Hospital Department of Respiratory Medicine Nanjing ChinaKai Xue, Fudan University Department of Medical Oncology, Cancer Hospital 270 Dong An Road 200032 Shanghai People’s Republic of ChinaHong Ding, Longgang Center for Disease Control a... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3090177 Thu, 10 Dec 2009 15:17:17 +0100 3090177 http://www.medworm.com/index.php?rid=3090178&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm6478v060578732h%2F Conclusion  Our findings have indicated that the individuals polymorphic for CYP1A1 MspI either with GSTM1 null or with GSTT1 null genotypes revealed an increased risk for UADT cancers than that ascribed to a single susceptible gene among the tobacco users in the population [single gene risk among smokers and chewers, respectively, for CYP1A1 MspI (OR 6.43; 95% CI 3.69–11.21); (OR 10.24; 95% CI 5.95–17.60), GSTM1*0 (OR 3.77; 95% CI 1.94–7.37); (OR 7.97 95% CI 4.10–15.76) and GSTT1*0 (OR 6.95 95% CI 2.88–16.77); (OR 25.83 95% CI 7.78–85.76). Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0738-6Authors Soya Sisy Sam, Jawaharlal Institute of Post-Graduate Medical Education and Research Pharmacogenomics Laboratory, Department of Pharma... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3090178 Thu, 10 Dec 2009 15:17:15 +0100 3090178 http://www.medworm.com/index.php?rid=3064092&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F15228rn22575w851%2F Conclusion  Most nonfunctional PTC is detected late due to a paucity of symptoms, of which a palpable neck mass is the most common. Patients with nonfunctioning PTC appear to have a poorer prognosis than do those with functioning parathyroid cancers. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0740-zAuthors Wen Chao Gao, Second Military Medical University Department of General Surgery, Shanghai Chang Zheng Hospital 415 Feng Yang Road 200003 Shanghai People’s Republic of ChinaCan Ping Ruan, Second Military Medical University Department of General Surgery, Shanghai Chang Zheng Hospital 415 Feng Yang Road 200003 Shanghai People’s Republic of ChinaJun Chu Zhang, Second Military Medical University Department of General Surgery, Shanghai Chan... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3064092 Fri, 04 Dec 2009 21:15:00 +0100 3064092 http://www.medworm.com/index.php?rid=3064091&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fhk76px3057w1u126%2F Conclusions  This is the first study to demonstrate increased H2O2 in exhaled breath condensate in patients with localized breast malignancy and its relation with clinical severity. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0734-xAuthors Robert A. Stolarek, Medical University of Lodz Department of Cardiovascular Physiology Mazowiecka St. 6/8 92-215 Lodz PolandElżbieta Potargowicz, Medical University of Lodz Department of Cellular Interactions Mazowiecka St. 6/8 92-215 Lodz PolandEwa Sęklewska, Medical University of Lodz Department of Cellular Interactions Mazowiecka St. 6/8 92-215 Lodz PolandJarosław Jakubik, Medical University of Lodz Department of Oncological Surgery Paderewskiego St. 4 93-509 Lodz PolandMarek Lewandowski, Center for ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3064091 Fri, 04 Dec 2009 21:15:00 +0100 3064091 http://www.medworm.com/index.php?rid=3064093&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa1284482l226514k%2F Abstract Introduction  Brachytherapy (BRT) is defined as a therapy technique where a radioactive source is placed a short distance from or within the tumor being treated. Much expectation has been placed on its efficacy to improve the outcome for patients with central nervous system (CNS) tumors due to the initial promising results from single institution retrospective studies. However, these optimistic findings have been highly debated since the selection criteria itself is preferable to other therapeutic modalities. The fact that BRT demonstrated no significant survival advantage in two prospective studies, together with the emerging role of stereotactic convergence therapy as a promising alternative, has further decreased the enthusiasm for BRT. Despite all the negative... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3064093 Wed, 02 Dec 2009 18:43:26 +0100 3064093 http://www.medworm.com/index.php?rid=3040635&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp50178625m5j51h4%2F Content Type Journal ArticleCategory ErratumDOI 10.1007/s00432-009-0737-7Authors Ewa Bien, Medical University of Gdansk Department of Paediatrics, Haematology, Oncology and Endocrinology 7 Debinki Street 80-211 Gdansk PolandMalgorzata Rapala, Marciniak Hospital Department of Paediatric Surgery Wroclaw PolandMalgorzata Krawczyk, Medical University of Gdansk Medical Student Association, Department of Paediatric, Haematology, Oncology and Endocrinology Gdansk PolandAnna Balcerska, Medical University of Gdansk Department of Paediatrics, Haematology, Oncology and Endocrinology 7 Debinki Street 80-211 Gdansk Poland Journal Journal of Cancer Research and Clinical OncologyOnline ISSN 1432-1335Print ISSN 0171-5216 (Source: Journal of Cancer Research and Clinical Oncology) Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3040635 Sun, 29 Nov 2009 09:31:44 +0100 3040635 http://www.medworm.com/index.php?rid=3040636&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0jm62u0j8820211u%2F Conclusions  Both histological grade and risk-category classification were effective in identifying women at risk of developing distant metastases after initial therapy for ER-positive, node-negative Stage I or IIA breast cancer. These patients may benefit from the addition of adjuvant therapy at diagnosis. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0736-8Authors Kyoko Yorozuya, Aichi Medical University Division of Breast and Endocrine Surgery, Department of Surgery, School of Medicine Nagakute-cho Aichi Aichi Prefecture 4801195 JapanToru Takeuchi, Marumo Hospital Department of Surgery 2-124-1 Hongo, Meitou-ku Nagoya Aichi Prefecture 4650024 JapanMiwa Yoshida, Aichi Medical University Division of Breast and Endocrine Surgery, Department o... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3040636 Sat, 28 Nov 2009 07:03:35 +0100 3040636 http://www.medworm.com/index.php?rid=3040637&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff1k8136100358143%2F Conclusions  NHT did not influence XIAP expression. We speculate that the inhibition of XIAP expression may reinforce the apoptotic effect of NHT and improve the prognosis in patients with prostate cancer. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0718-xAuthors Shin-ichi Watanabe, Nagasaki University School of Medicine Department of Urology 1-7-1 Sakamoto Nagasaki 852-8501 JapanYasuyoshi Miyata, Nagasaki University School of Medicine Department of Urology 1-7-1 Sakamoto Nagasaki 852-8501 JapanShigeru Kanda, National Hospital Organization Nagasaki Hospital 6-41 Sakuragi-cho Nagasaki 852-8501 JapanTakahisa Iwata, Nagasaki University School of Medicine Department of Urology 1-7-1 Sakamoto Nagasaki 852-8501 JapanTomayoshi Hayashi, Nagasaki Un... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3040637 Sat, 28 Nov 2009 07:03:34 +0100 3040637 http://www.medworm.com/index.php?rid=3040638&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg33186v306kh4u55%2F Conclusions  Together with our previous observations, our data show that DHA induces cell cycle arrest and apoptosis in pancreatic cancer cells, and this effect might be due to inhibition of NF-κB signaling. We suggest that DHA could be developed as a novel agent against pancreatic cancer. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0731-0Authors Hua Chen, The First Affiliated Hospital of Harbin Medical University Department of Hepatobiliary and Pancreatic Surgery 23 Youzheng Street, Nangang District 150001 Harbin ChinaBei Sun, The First Affiliated Hospital of Harbin Medical University Department of Hepatobiliary and Pancreatic Surgery 23 Youzheng Street, Nangang District 150001 Harbin ChinaShuangjia Wang, The First Affiliated Hospital of... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3040638 Thu, 26 Nov 2009 07:59:19 +0100 3040638 http://www.medworm.com/index.php?rid=3031634&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fcwx3w515t16w8407%2F Conclusions  Ectopic expression of Ebp1 mediates multiple antitumor activities against OSCC, suggesting a potential of Ebp1-based novel therapy for clinical OSCC treatment. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0730-1Authors Xu Zhou, Fudan University Zhongshan Hospital 200032 Shanghai ChinaWantao Chen, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology Ninth People’s Hospital 200011 Shanghai ChinaYuexing Zhang, University of Maryland Greenebaum Cancer Center Baltimore MD 21201 USAJian Sun, Fudan University Zhongshan Hospital 200032 Shanghai ChinaQing Wang, Fudan University Zhongshan Hospital 200032 Shanghai ChinaYoucheng Yu, Fudan University Zhongshan Hospital 200032 Shanghai China Journa... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3031634 Tue, 24 Nov 2009 07:09:51 +0100 3031634 http://www.medworm.com/index.php?rid=3019946&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8156539812055k07%2F In this study, a novel method using this combined approach was developed to analyze the gene expression patterns in lymphatic endothelial cells (LECs). First, LECs were identified in frozen sections using rapid immunostaining and isolated using LCM, and then intact RNA from the LECS was purified and amplified. The expression profile was analyzed using microarray analysis, and the expression of selected genes (Sema4C and C4orf7) was evaluated by quantitative RT-PCR (qRT-PCR) and immunofluorescence assays. These results indicate that the combination of RIHC–LCM, two-round linear amplification of the small sample RNA and genome-wide microarray analysis allows gene expression profiling of tumor LECs, which provides a powerful tool for the study of molecular details in human lymphangioge... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3019946 Sat, 21 Nov 2009 09:08:48 +0100 3019946 http://www.medworm.com/index.php?rid=3019947&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0h2j664546673157%2F Conclusion  The present study suggests that UHGPSs are derived from BM stromal cells, probably mesenchymal stem cells. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0723-0Authors Qing Li, Kansai Medical University First Department of Pathology Moriguchi City Osaka JapanHiroko Hisha, Kansai Medical University First Department of Pathology Moriguchi City Osaka JapanTakashi Takaki, Kansai Medical University First Department of Pathology Moriguchi City Osaka JapanYasushi Adachi, Kansai Medical University First Department of Pathology Moriguchi City Osaka JapanMing Li, Kansai Medical University First Department of Pathology Moriguchi City Osaka JapanChangye Song, Kansai Medical University First Department of Pathology Moriguchi City Osaka JapanWei ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3019947 Sat, 21 Nov 2009 09:08:47 +0100 3019947 http://www.medworm.com/index.php?rid=3016026&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe288nn234v562641%2F Conclusions  The present study shows that tumor volume parameters, especially the combination of MTV and SUV in the “metabolic index”, are valuable for predicting long-term survival. High MI may be useful for identifying patients requiring more aggressive treatment. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0729-7Authors Peng Xie, Shandong Tumor Hospital and Institute Department of Radiation Oncology Jiyan Road 440 250117 Jinan Shandong ChinaJin-Bo Yue, Shandong Tumor Hospital and Institute Department of Radiation Oncology Jiyan Road 440 250117 Jinan Shandong ChinaHan-xi Zhao, Shandong Tumor Hospital and Institute Department of Radiation Oncology Jiyan Road 440 250117 Jinan Shandong ChinaXin-Dong Sun, Shandong Tumor Hospital and Insti... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3016026 Thu, 19 Nov 2009 20:00:51 +0100 3016026 http://www.medworm.com/index.php?rid=3016027&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fux4w042l54vm5752%2F Conclusion  Our preliminary data suggest that DNA methylation biomarkers may assist in selection of BC patients for efficient IL-2 therapy. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0725-yAuthors Sonata Jarmalaite, Vilnius University Faculty of Natural Sciences Ciurlionio 21 3101 Vilnius LithuaniaRasa Andrekute, Vilnius University Faculty of Natural Sciences Ciurlionio 21 3101 Vilnius LithuaniaAsta Scesnaite, Vilnius University Faculty of Natural Sciences Ciurlionio 21 3101 Vilnius LithuaniaKestutis Suziedelis, Vilnius University Institute of Oncology Vilnius LithuaniaKirsti Husgafvel-Pursiainen, Finnish Institute of Occupational Health Biological Mechanisms and Prevention of Work-Related Diseases Helsinki FinlandFeliksas Jankevicius, Viln... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3016027 Thu, 19 Nov 2009 07:41:57 +0100 3016027 http://www.medworm.com/index.php?rid=3016029&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F41144r456n880108%2F Conclusion  Polymorphisms and haplotypes in XPC appear to influence susceptibility to BC risk. The variant C allele at Lys939Gln may be responsible for early recurrence in BCG-treated patients. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0717-yAuthors Ruchika Gangwar, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS) Department of Urology and Renal Transplantation Raebareli Road Lucknow Uttar Pradesh 226014 IndiaAnil Mandhani, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS) Department of Urology and Renal Transplantation Raebareli Road Lucknow Uttar Pradesh 226014 IndiaRama Devi Mittal, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS) Department of Urology and Renal Transplantation Ra... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3016029 Wed, 18 Nov 2009 19:15:26 +0100 3016029 http://www.medworm.com/index.php?rid=3016028&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc8m8u06537k633k6%2F Conclusions  DP1L1 polymorphisms are associated with colon cancer and IBD. This indicates that DP1L1 plays a functional role in these conditions. Thus DP1L1 may be a diagnostic and therapeutic target for colon cancer and IBD. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0719-9Authors Axel Wellmann, Institute of Pathology Celle Wittingerstrasse 14 29223 Celle GermanyFranz Fogt, University of Pennsylvania Presbyterian Medical Center Philadelphia PA USAStephan Hollerbach, AKH Celle Department of Gastroenterology Celle GermanyJens Hahne, University of Bonn Institute of Pathology Bonn GermanyKerstin Koenig-Hoffmann, Xantos Biomedicine AG Max-Lebsche-Platz 31 81377 München GermanyDaniela Smeets, Institute of Pathology, RWTH Aachen Aachen GermanyU... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3016028 Wed, 18 Nov 2009 19:15:26 +0100 3016028 http://www.medworm.com/index.php?rid=3009552&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fvj5w1454l4497186%2F Conclusion  Quantitative real-time PCR analysis confirmed microarray data. The report supports that many miRNA expressions were altered in renal carcinoma, whose expression profiling may provide a useful clue for the pathophysiology research. However, further longer-term researches are required to investigate the relationship between miRNA and renal carcinoma as well as their role in carcinogenesis. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0726-xAuthors Zhengjun Yi, Weifang Medical University Department of Laboratory Medicine of Clinical Faculty Weifang ChinaYurong Fu, Weifang Medical University Department of Medical Microbiology No.7166, Baotong Xi (Western) Street 261053 Weifang Shandong ChinaShushu Zhao, Weifang Medical University D... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3009552 Tue, 17 Nov 2009 23:51:11 +0100 3009552 http://www.medworm.com/index.php?rid=3009553&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4616460815605271%2F Conclusion  We found that MSCs possessed great migratory capacity in vitro and the human ovarian adenocarcinoma cell line SKOV3 could significantly induce the migration of MSCs. Our results provided evidence that MSCs could be utilized as a powerful delivery system of endostatin. The endostatin produced by MSC-EN cells could inhibit the proliferation of SKOV3 cells. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0728-8Authors Jing Jiang, The Second Affiliated Hospital of Harbin Medical University Department of Obstetrics and Gynecology No. 246, Xue Fu Road, Nan Gang District 150001 Harbin Hei Longjiang ChinaWei Chen, The Second Affiliated Hospital of Harbin Medical University Department of Cardiovascular Surgery Harbin Hei Longjiang ChinaRuji... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=3009553 Tue, 17 Nov 2009 23:51:09 +0100 3009553 http://www.medworm.com/index.php?rid=2996693&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8qg12l624574855x%2F Conclusion  The new staging system, accounting for both liver function and tumor characteristics, can accurately identify patients with different prognoses, particularly in the advanced phases of HCC. It should be useful as the only tool that can be applied for patients with unresectable HCC. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0722-1Authors Bai-Hong Zhang, General Hospital of People’s Liberation Army Department of Oncology 730050 Lanzhou ChinaXiang-Hui Wang, General Hospital of People’s Liberation Army Department of Oncology 730050 Lanzhou ChinaHong-Yun Yue, General Hospital of People’s Liberation Army Department of Ophthalmology 730050 Lanzhou ChinaChang-Quan Ling, Second Military Medical University Department of Traditiona... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=2996693 Sat, 14 Nov 2009 20:38:15 +0100 2996693 http://www.medworm.com/index.php?rid=2996695&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe66767g636p073j7%2F Conclusions  Our results suggest that mutations and/or alterations in expression of TGF-β receptors and loss of Smad 4 are frequent in human ovarian cancers and may potentially explain the frequent loss of TGF-β responsiveness that typically occurs in human ovarian cancer. Content Type Journal ArticleCategory Orginal PaperDOI 10.1007/s00432-009-0703-4Authors Marie Lue Antony, Rajiv Gandhi Center for Biotechnology Division of Cancer Biology Thiruvananthapuram Kerala 695014 IndiaRema Nair, Regional Cancer Center Department of Surgical Oncology Thiruvananthapuram Kerala 695011 IndiaPaul Sebastian, Regional Cancer Center Department of Surgical Oncology Thiruvananthapuram Kerala 695011 IndiaDevarajan Karunagaran, Rajiv Gandhi Center for Biotechnology Division of Cancer Bi... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=2996695 Sat, 14 Nov 2009 20:38:09 +0100 2996695 http://www.medworm.com/index.php?rid=2996694&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fej452w7762014342%2F Conclusions  From our findings we conclude that bacoside A is effective to prevent DEN-induced hepatocellular carcinoma by quenching lipid peroxidation and enhancing antioxidant status through free radical scavenging mechanism and having potential of protecting endogenous enzymatic and non-enzymatic antioxidant activity. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0715-0Authors Panneerselvam Janani, Presidency College Department of Zoology Chennai 600005 Tamil Nadu IndiaKanakarajan Sivakumari, Presidency College Department of Zoology Chennai 600005 Tamil Nadu IndiaArumugam Geetha, Bharathi Women’s College Department of Biochemistry Chennai 600108 Tamil Nadu IndiaBaskaran Ravisankar, University of Madras Department of Endocrinology, Dr. A... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=2996694 Sat, 14 Nov 2009 20:38:09 +0100 2996694 http://www.medworm.com/index.php?rid=2996697&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw1124p44243v667h%2F Conclusions  We found variations in MMP/TIMP expressions among the different histological subtypes of breast carcinomas suggesting differences in their tumor pathophysiology Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0721-2Authors J. M. Del Casar, Fundación Hospital de Jove Unidad de Investigación Avda. Eduardo Castro s/n 33290 Gijón Asturias SpainS. González-Reyes, Fundación Hospital de Jove Unidad de Investigación Avda. Eduardo Castro s/n 33290 Gijón Asturias SpainL. O. González, Fundación Hospital de Jove Unidad de Investigación Avda. Eduardo Castro s/n 33290 Gijón Asturias SpainJ. M. González, Fundación Hospital de Jove Unidad de Investigación Avda. Eduardo Castro s/n 33290 Gijón Asturias SpainS. Junquera, Fundación Hos... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=2996697 Sat, 14 Nov 2009 20:38:08 +0100 2996697 http://www.medworm.com/index.php?rid=2996696&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw1516138j2713526%2F Conclusions  We reported the expression of IL-13Rα2 in liver cancer cell lines and tissues as well as investigated the cytotoxin (DT389-hIL13-13E13K) targeted killing efficiency of liver cancer cells and potential role of IL-13Rα2 in the cancer treatment. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0724-zAuthors Lingling Hou, Beijing Jiaotong University College of Life Sciences and Bioengineering 100044 Beijing People’s Republic of ChinaJuan Du, Beijing Jiaotong University College of Life Sciences and Bioengineering 100044 Beijing People’s Republic of ChinaJianwei Wang, Chinese Academy of Medical Sciences Institute of Pathogen Biology, Peking Union Medical College 100730 Beijing People’s Republic of ChinaYanfeng Liu, Beijing Jiaoton... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=2996696 Sat, 14 Nov 2009 20:38:08 +0100 2996696 http://www.medworm.com/index.php?rid=2996698&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F92642t20116kwk49%2F Conclusions  MIF has been shown to promote tumor immune escape mechanisms in other cancer entities, which makes it an interesting target for cancer therapy, given the known significance of immune mechanisms for uterine cervical cancer. The overexpression of MIF on the protein and mRNA level, as well as its secretion by cervical cancer cells points to a critical role of the protein for the pathogenesis of uterine cervical cancer. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0702-5Authors Mathias Krockenberger, University of Wuerzburg Department of Obstetrics and Gynecology Josef-Schneider-Str. 4 97080 Würzburg GermanyJörg B. Engel, University of Wuerzburg Department of Obstetrics and Gynecology Josef-Schneider-Str. 4 97080 Würzburg Germa... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=2996698 Fri, 13 Nov 2009 18:22:32 +0100 2996698 http://www.medworm.com/index.php?rid=2996699&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg26q724347k70534%2F Conclusion  Further studies are warranted to investigate cathepsins as possible prognostic biomarkers for the aggressiveness of ovarian cancer. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0716-zAuthors Eva Kolwijck, Radboud University Nijmegen Medical Centre Department of Obstetrics and Gynecology Nijmegen The NetherlandsLeon F. A. G. Massuger, Radboud University Nijmegen Medical Centre Department of Obstetrics and Gynecology Nijmegen The NetherlandsChris M. G. Thomas, Radboud University Nijmegen Medical Centre Department of Chemical Endocrinology Nijmegen The NetherlandsPaul N. Span, Radboud University Nijmegen Medical Centre Department of Chemical Endocrinology Nijmegen The NetherlandsMarta Krasovec, University of Ljubljana Faculty of Pha... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=2996699 Fri, 13 Nov 2009 18:22:31 +0100 2996699 http://www.medworm.com/index.php?rid=2986119&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg00227l13r77640m%2F Conclusions  Our results suggest that genetic instabilities of the E-cadherin gene have a role in meningioma development and progression. Detected microsatellite instability indicates that mismatch repair may also be targeted in meningioma. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0708-zAuthors Nives Pećina-Šlaus, University of Zagreb Laboratory of Neurooncology, Croatian Institute for Brain Research, School of Medicine Šalata 12 10000 Zagreb CroatiaTamara Nikuševa Martić, University of Zagreb Laboratory of Neurooncology, Croatian Institute for Brain Research, School of Medicine Šalata 12 10000 Zagreb CroatiaAdam Jakov Deak, University of Zagreb Laboratory of Neurooncology, Croatian Institute for Brain Research, School of Medicine ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=2986119 Wed, 11 Nov 2009 19:21:13 +0100 2986119 http://www.medworm.com/index.php?rid=2986118&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F173wn5750765u1v1%2F Conclusions  XRCC1 genotype independently predicted overall survival in metastatic colorectal carcinoma patients treated with irinotecan-based chemotherapy. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0720-3Authors Mehmet Artac, Selcuk University Department of Medical Oncology, Meram Medical Faculty Meram 42080 Konya TurkeyHakan Bozcuk, Akdeniz University Department of Medical Oncology, Medical Faculty Antalya TurkeySacide Pehlivan, Gaziantep University Department of Medical Biology, Medical Faculty Gaziantep TurkeySongül Akcan, Akdeniz University Department of Internal Medicine, Medical Faculty Antalya TurkeyMustafa Pehlivan, Gaziantep University Department of Hematology, Medical Faculty Gaziantep TurkeyTugce Sever, Gaziantep University D... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=2986118 Wed, 11 Nov 2009 19:21:13 +0100 2986118 http://www.medworm.com/index.php?rid=2986120&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy0w3q847611l021m%2F Conclusion  Functional IL-1B genotypes may modify plasma IL-1β concentrations to contribute to the etiology of cervical cancer in Chinese women; however, further perspective studies are warranted to test the causal effects of IL-1β concentration in cervical carcinogenesis. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0710-5Authors Nianfeng Qian, Nanjing Medical University Laboratory of Reproductive Medicine 210029 Nanjing ChinaXiaojun Chen, Nanjing Medical University Laboratory of Reproductive Medicine 210029 Nanjing ChinaSuping Han, Nanjing Medical University Laboratory of Reproductive Medicine 210029 Nanjing ChinaFulin Qiang, Tumor Hospital of Nantong City 226000 Nantong ChinaGuangfu Jin, Nanjing Medical University Laboratory of Reproduc... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=2986120 Tue, 10 Nov 2009 18:45:20 +0100 2986120 http://www.medworm.com/index.php?rid=2986122&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff224jj5038073184%2F Conclusion  The results indicate that the two SNPs have a functional influence on the VEGF-A protein levels in normal colorectal tissue. The possible clinical implications of the findings need further investigation. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0714-1Authors Torben F. Hansen, Vejle Hospital Vejle DenmarkKaren-Lise G. Spindler, Vejle Hospital Vejle DenmarkKaren A. Lorentzen, Vejle Hospital Vejle DenmarkDorte A. Olsen, Vejle Hospital Vejle DenmarkRikke F. Andersen, Vejle Hospital Vejle DenmarkJan Lindebjerg, Vejle Hospital Vejle DenmarkIvan Brandslund, Vejle Hospital Vejle DenmarkAnders Jakobsen, Vejle Hospital Vejle Denmark Journal Journal of Cancer Research and Clinical OncologyOnline ISSN 1432-1335Print ISSN 0171-5216... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=2986122 Tue, 10 Nov 2009 18:45:19 +0100 2986122 http://www.medworm.com/index.php?rid=2986121&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp734828644772106%2F Conclusions  In medically fit older patients, bevacizumab provides similar PFS and OS benefits as in younger patients. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0712-3Authors James Cassidy, Cancer Research UK Glasgow UKLeonard B. Saltz, Memorial Sloan-Kettering Cancer Center New York NY USABruce J. Giantonio, University of Pennsylvania Philadelphia PA USAFairooz F. Kabbinavar, UCLA School of Medicine Los Angeles CA USAHerbert I. Hurwitz, Duke University Medical Center Durham NC USAUlrich-Peter Rohr, F. Hoffmann-La Roche Basel Switzerland Journal Journal of Cancer Research and Clinical OncologyOnline ISSN 1432-1335Print ISSN 0171-5216 (Source: Journal of Cancer Research and Clinical Oncology) Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=2986121 Tue, 10 Nov 2009 18:45:19 +0100 2986121 http://www.medworm.com/index.php?rid=2971434&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F77423277776q8g23%2F Conclusions  G-actin stability may imply its potential usefulness for permanent senescence detection. Along with slight to moderate cytoskeletal alterations, the obtained results suggest transient senescence-like state induction, followed by morphology typical of mitotic catastrophe in part of the A549 cells. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0711-4Authors Anna Litwiniec, Nicolaus Copernicus University in Toruń Department of Histology and Embryology, Ludwik Rydygier Collegium Medicum in Bydgoszcz Karłowicza 24 85-092 Bydgoszcz PolandAlina Grzanka, Nicolaus Copernicus University in Toruń Department of Histology and Embryology, Ludwik Rydygier Collegium Medicum in Bydgoszcz Karłowicza 24 85-092 Bydgoszcz PolandAnna Helmin-Basa,... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=2971434 Fri, 06 Nov 2009 18:57:54 +0100 2971434 http://www.medworm.com/index.php?rid=2971436&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx5122w06x71l346n%2F Conclusions  Our study indicates a proportionally higher area of hyaluronan expression in DCIS with a microinvasive component than in pure DCIS, suggesting a key role of this glycosaminoglycan in the early invasive phase of breast carcinomas. Thus, hyaluronan could play an important function in determining the migratory phenotype of cancer cells. Larger size tumors appear to demonstrate an intricate balance between hyaluronan synthesis and degradation, thus conditioning intratumoral heterogeneity in the hyaluronan metabolism. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0713-2Authors Maria Daniela Corte, Hospital de Jove Unidad de Investigación Gijón SpainLuis Ovidio González, Hospital de Jove Unidad de Investigación Gijón SpainSara ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=2971436 Fri, 06 Nov 2009 18:57:53 +0100 2971436 http://www.medworm.com/index.php?rid=2971435&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7351457g1t0m5v78%2F Conclusions  Our results suggest that HMGB1 protein is a valuable marker for progression of CRC patients. High HMGB1 expression is associated with poor overall survival in patients with CRC. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0706-1Authors Xingjun Yao, The First Affiliated Hospital of Jilin University Department of Surgery 130021 Changchun People’s Republic of ChinaGang Zhao, The First Affiliated Hospital of Jilin University Department of Surgery 130021 Changchun People’s Republic of ChinaHongfa Yang, The First Affiliated Hospital of Jilin University Department of Surgery 130021 Changchun People’s Republic of ChinaXinyu Hong, The First Affiliated Hospital of Jilin University Department of Surgery 130021 Changchun People’s R... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=2971435 Fri, 06 Nov 2009 18:57:53 +0100 2971435 http://www.medworm.com/index.php?rid=2971437&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn72p13q714648724%2F Conclusion  In summary, tetrandrine can prevent doxorubicin-induced mdr1 mRNA/P-gp expression and P-gp functions in a dose-dependent manner through a mechanism that may involve inhibition of doxorubicin-induced NF-κB mRNA expression and protein activity. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0704-3Authors Huiling Shen, Jiangsu University The Affiliated People’s Hospital Zhenjiang Jiangsu ChinaWenlin Xu, Jiangsu University The Affiliated People’s Hospital Zhenjiang Jiangsu ChinaQiaoyun Chen, Jiangsu University The Affiliated People’s Hospital Zhenjiang Jiangsu ChinaZhaoyang Wu, Jiangsu University The Affiliated People’s Hospital Zhenjiang Jiangsu ChinaHuarong Tang, Jiangsu University The Affiliated People’s Hospital Zhenjian... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=2971437 Fri, 06 Nov 2009 18:57:52 +0100 2971437