Journal of Cancer Research and Clinical Oncology via MedWorm.com MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Journal of Cancer Research and Clinical Oncology' source. Wed, 08 Feb 2012 08:41:37 +0100 Higher cell stiffness indicating lower metastatic potential in B16 melanoma cell variants and in (−)-epigallocatechin gallate-treated cells http://www.medworm.com/index.php?rid=5659394&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F84j25t657372q367%2F Conclusions  Our study with AFM clearly demonstrates that cell stiffness is a reliable quantitative indicator of migration potential, and very likely metastatic potential, even in morphologically similar cells. And increased cell stiffness may be a key nanomechanical feature in inhibition of metastasis. Content Type Journal ArticleCategory Original PaperPages 1-8DOI 10.1007/s00432-012-1159-5Authors Tatsuro Watanabe, Research Institute for Clinical Oncology, Saitama Cancer Center, Kitaadachi-gun, Saitama, 362-0806 JapanHiromi Kuramochi, National Institute for Materials Science, International Center for Materials Nanoarchitectonics, Ibaraki, JapanAtsushi Takahashi, Research Institute for Clinical Oncology, Saitama Cancer Center, Kitaadachi-gun, Saitama, 362-0806 JapanK... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5659394 Wed, 01 Feb 2012 17:13:19 +0100 5659394 Comparison of ER/PR and HER2 statuses in primary and paired liver metastatic sites of breast carcinoma in patients with or without treatment http://www.medworm.com/index.php?rid=5659396&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3561796808445312%2F Conclusions  ER/PR and HER2 statuses between primary and liver metastatic lesions of breast carcinoma can be modified after treatment but are stable in most cases during the natural metastatic process. Content Type Journal ArticleCategory Original PaperPages 1-6DOI 10.1007/s00432-012-1150-1Authors Jieqiong Liu, Department of Breast Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of ChinaHeran Deng, Department of Breast Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of ChinaWeijuan Jia, Department of Breast Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of ChinaYunjie Zeng, Department of Pathology, Sun Yat-Sen Memorial Hospital,... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5659396 Tue, 31 Jan 2012 07:10:50 +0100 5659396 Relevance of MET activation and genetic alterations of KRAS and E-cadherin for cetuximab sensitivity of gastric cancer cell lines http://www.medworm.com/index.php?rid=5659395&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb2u66387845m0725%2F Conclusion  These data indicate that our examinations may be clinically relevant, and the candidate markers should therefore be tested in clinical studies. Content Type Journal ArticleCategory Original PaperPages 1-16DOI 10.1007/s00432-011-1128-4Authors Stefan Heindl, Institut für Allgemeine Pathologie und Pathologische Anatomie, Technische Universität München, Klinikum rechts der Isar, Trogerstr. 18, 81675 Munich, GermanyEvelyn Eggenstein, Institut für Allgemeine Pathologie und Pathologische Anatomie, Technische Universität München, Klinikum rechts der Isar, Trogerstr. 18, 81675 Munich, GermanySimone Keller, Institut für Allgemeine Pathologie und Pathologische Anatomie, Technische Universität München, Klinikum rechts der Isar, Trogerstr. 18, 81675 Munich, Ge... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5659395 Tue, 31 Jan 2012 07:10:50 +0100 5659395 DNA methylation status of REIC/Dkk-3 gene in human malignancies http://www.medworm.com/index.php?rid=5638063&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx677v88pt73j0307%2F Conclusions   REIC/Dkk-3 type-a methylation was frequently detected in a broad range of cancers and appeared to play a key role in silencing REIC/Dkk-3 type-a expression in these malignancies. Content Type Journal ArticleCategory Original PaperPages 1-11DOI 10.1007/s00432-012-1158-6Authors Tatsuro Hayashi, Department of Cancer and Thoracic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama, 700-8558 JapanHiroaki Asano, Department of Cancer and Thoracic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama, 700-8558 JapanShinichi Toyooka, Department of Cancer and Thoracic Surgery, Graduate School of Medicine, Dentistry and Pharm... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5638063 Tue, 24 Jan 2012 12:27:14 +0100 5638063 Effects of the inhibition of cytosolic phospholipase A2α in non-small cell lung cancer cells http://www.medworm.com/index.php?rid=5638064&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fwk646578632g9723%2F Conclusions  Pyrrolidine-2 is a more potent and specific cPLA2α inhibitor than MAFP and AACOCF3 and represents an excellent pharmacological tool to investigate the biosynthesis and the biological roles of cancer. The present study suggests that pyrrolidine-2 could be a potential therapeutic agent for cancer therapy. Content Type Journal ArticleCategory Original PaperPages 1-9DOI 10.1007/s00432-012-1157-7Authors Shenbagamoorthy Sundarraj, Proteomics and Molecular Cell Physiology Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore, 641046 TN, IndiaSoundarapandian Kannan, Proteomics and Molecular Cell Physiology Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore, 641046 TN, IndiaRamar ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5638064 Tue, 24 Jan 2012 12:27:13 +0100 5638064 Methotrexate-mediated inhibition of RAD51 expression and homologous recombination in cancer cells http://www.medworm.com/index.php?rid=5638066&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F503866760060k55p%2F Conclusions  These results demonstrate that methotrexate can affect homologous recombination repair of DNA double-strand breaks by controlling the expression of homologous recombination-related genes and suppressing the proper assembly of homologous recombination–directed subnuclear foci. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s00432-011-1132-8Authors Li-Qing Du, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin Key Laboratory of Molecular Nuclear Medicine, 300192 Tianjin, ChinaXiao-Qing Du, Division of International Cooperation and Exchanges, Inner Mongolia University of Technology, 010051 Inner Mongolia, ChinaJian-Qiang Bai, Department of Spine Surgery, Tianjin Hospita... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5638066 Tue, 24 Jan 2012 12:27:12 +0100 5638066 The prognostic value of elevated vascular endothelial growth factor in patients with osteosarcoma: a meta-analysis and systemic review http://www.medworm.com/index.php?rid=5638065&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd2434uj712ju225n%2F Conclusions  The prognostic significance of VEGF expression in all its isoforms is still unknown based on the limited data available, but we find VEGF165 may play an important role. Future studies should examine the relationship between VEGF isoform expression and patients’ survival and the relationship between VEGF isoform expression and EMMPRIN expression, which could be helpful for predicting the prognosis of patients with osteosarcoma. Once the conclusion of whether the VEGF and its isoforms playing a role in osteosarcoma were reached, it would help guide clinical decision-making regarding therapy and outcomes. In addition, we recommend a >25% positive staining of the cells as a VEGF-positive cut-off value in immunohistochemistry, since we find a relatively strict ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5638065 Tue, 24 Jan 2012 12:27:12 +0100 5638065 Escin augments the efficacy of gemcitabine through down-regulation of nuclear factor-κB and nuclear factor-κB-regulated gene products in pancreatic cancer both in vitro and in vivo http://www.medworm.com/index.php?rid=5638068&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw725767685172m17%2F Conclusion  These data suggest that escin, via inactivation of NF-κB, could potentiate the efficacy of gemcitabine in combating pancreatic cancer, which could be a novel and potentially important therapeutic approach for the treatment for pancreatic cancer. Content Type Journal ArticleCategory Original PaperPages 1-13DOI 10.1007/s00432-012-1152-zAuthors Yong-Wei Wang, Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, 23 Youzheng Str, Nangang, Harbin, People’s Republic of ChinaShuang-Jia Wang, Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, 23 Youzheng Str, Nangang, Harbin, People’s Republic of ChinaYi-Nan Zhou, Department of Pancreatic... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5638068 Tue, 24 Jan 2012 07:30:41 +0100 5638068 MicroRNA-223 functions as an oncogene in human gastric cancer by targeting FBXW7/hCdc4 http://www.medworm.com/index.php?rid=5638067&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe73873634m326152%2F Conclusion  In summary, the data indicated that miR-223 targets FBXW7/hCdc4 expression at the post-transcriptional level and appears to regulate cellular apoptosis, proliferation, and invasion in gastric cancer. MiR-223 may serve as a novel therapeutic target in gastric cancer. Content Type Journal ArticleCategory Original PaperPages 1-12DOI 10.1007/s00432-012-1154-xAuthors Jinhai Li, Department of Gastrointestinal Surgery, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029 Jiangsu, People’s Republic of ChinaYuanyuan Guo, Department of Biochemistry and Molecular Biology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210002 Jiangsu, People’s Republic of ChinaXiaodi Liang, Department of Biochemistry and Molecular ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5638067 Tue, 24 Jan 2012 07:30:41 +0100 5638067 Estrogenic transmembrane receptor of GPR30 mediates invasion and carcinogenesis by endometrial cancer cell line RL95-2 http://www.medworm.com/index.php?rid=5638069&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5178095606753338%2F Conclusions  Our data suggest that, for the endometrial cancer cell line RL95-2, GPR30 plays important roles in mediating the proliferative and invasive effects of estrogen and in tumorigenesis. Content Type Journal ArticleCategory Original ArticlePages 1-9DOI 10.1007/s00432-011-1133-7Authors Yin-Yan He, Department of Obstetrics and Gynecology, Shanghai First People’s Hospital, Shanghai Jiao Tong University, Shanghai, ChinaGui-Qiang Du, Department of Obstetrics and Gynecology, The International Peace Maternity and Child Health Hospital of the China Welfare Institute Affiliated to Shanghai Jiao Tong University, 910, Hengshan Road, Shanghai, ChinaBin Cai, Department of Obstetrics and Gynecology, Shanghai First People’s Hospital, Shanghai Jiao Tong University, Shangh... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5638069 Tue, 24 Jan 2012 07:30:39 +0100 5638069 Serum prolidase activity, oxidative stress, and nitric oxide levels in patients with bladder cancer http://www.medworm.com/index.php?rid=5619673&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp5534012n2442630%2F Conclusions  Our results show that increased prolidase seems to be associated with increased NO levels and oxidative stress along with decreased antioxidant levels in bladder cancer. Content Type Journal ArticleCategory Original ArticlePages 1-5DOI 10.1007/s00432-011-1136-4Authors Ilhan Gecit, Department of Urology, Medical Faculty, Yuzuncu Yil University, Van, TurkeyMehmet Aslan, Department of Internal Medicine, Medical Faculty, Yuzuncu Yil University, 65400 Van, TurkeyMustafa Gunes, Department of Urology, Medical Faculty, Yuzuncu Yil University, Van, TurkeyNecip Pirincci, Department of Urology, Medical Faculty, Yuzuncu Yil University, Van, TurkeyRamazan Esen, Department of Internal Medicine, Medical Faculty, Yuzuncu Yil University, 65400 Van, TurkeyHalit Demir, Depa... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5619673 Thu, 19 Jan 2012 06:53:37 +0100 5619673 Effectiveness and safety of pemetrexed-based doublet versus pemetrexed alone as second-line treatment for advanced non-small-cell lung cancer: a systematic review and meta-analysis http://www.medworm.com/index.php?rid=5619674&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn64244l40805u220%2F Conclusion  Pemetrexed-based doublet therapy didn’t gain any benefit in survival but significantly improved PFS and better ORR compared with single-agent pemetrexed as second-line therapy for advanced non-small-cell lung cancer. However, more incidences of grade 3 or 4 neutropenia, thrombocytopenia, and leucopenia were observed in pemetrexed-based doublet group. Content Type Journal ArticleCategory Original PaperPages 1-7DOI 10.1007/s00432-012-1155-9Authors Wei-Xiang Qi, Department of Oncology, The Sixth People Hospital, Shanghai Jiao Tong University, Shanghai, 200233 ChinaLi-Na Tang, Department of Oncology, The Sixth People Hospital, Shanghai Jiao Tong University, Shanghai, 200233 ChinaAi-Na He, Department of Oncology, The Sixth People Hospital, Shanghai Jiao Tong... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5619674 Thu, 19 Jan 2012 06:53:35 +0100 5619674 Application of ex vivo 1H NMR metabonomics to the characterization and possible detection of renal cell carcinoma metastases http://www.medworm.com/index.php?rid=5619675&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F668r500161677016%2F Conclusions  Systemic changes in metabolite concentrations are most likely the result of cells switching to glycolysis to maintain energy homeostasis. The results suggest that metabonomics may also facilitate the discovery of novel cancer biomarkers and allows the stratification of tumors under different pathophysiological conditions, which might be a valuable future tool for RCC detection and possibly other cancers. Content Type Journal ArticleCategory Original ArticlePages 1-9DOI 10.1007/s00432-011-1134-6Authors Hongchang Gao, School of Pharmacy, and Radiology Department of the Second Affiliated Hospital, Wenzhou Medical College, Wenzhou, 325035 People’s Republic of ChinaBaijun Dong, Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong U... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5619675 Thu, 19 Jan 2012 06:53:34 +0100 5619675 Tumor suppressor gene BLU is frequently downregulated by promoter hypermethylation in myelodysplastic syndrome http://www.medworm.com/index.php?rid=5608144&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk5hp642112876q56%2F Conclusion  BLU promoter hypermethylation frequently occurs in MDS cases, especially in higher risk MDS cases, and is significantly associated with the downregulated expression of BLU. BLU gene re-expression was induced in some MDS cases undergoing decitabine therapy. BLU may play a substantial role in the development and etiology of MDS. Content Type Journal ArticleCategory Original PaperPages 1-9DOI 10.1007/s00432-012-1151-0Authors Yujuan Yang, Department of Hematology, The Sixth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Jiaotong University, 600, Yishan Road, Shanghai, 200233 People’s Republic of ChinaQingxia Zhang, Department of Hematology, The Sixth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shangh... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5608144 Sat, 14 Jan 2012 16:42:32 +0100 5608144 Racial disparities in treatment for pancreatic cancer and impact on survival: a population-based analysis http://www.medworm.com/index.php?rid=5608143&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl2049012876mup51%2F Conclusion  Blacks have worst survival from locoregional pancreatic cancer. Receiving treatment for pancreatic cancer only explains 25% of the poorer survival amongst blacks, suggesting role of other factors. Studies are suggested to (a) identify barriers in receipt of treatment for pancreatic cancer amongst blacks and (b) to assess role of genetic and other factors to examine racial differences in survival. Content Type Journal ArticleCategory Original PaperPages 1-8DOI 10.1007/s00432-012-1156-8Authors Vinamrata Singal, Departments of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX, USAAshwani K. Singal, Department of Gastroenterology-Hepatology, Mayo Clinic, 200 First St SW, Rochester, MN 55905-0001, USAYong-Fang Kuo, Department of... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5608143 Sat, 14 Jan 2012 16:42:32 +0100 5608143 Inducible expression of tissue factor in small-cell lung cancer: impact on morphology and matrix metalloproteinase secretion http://www.medworm.com/index.php?rid=5596927&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3725x132n0151520%2F Conclusions  Our data show the significance of TF expression in the reversible growth phenotype of H69. Because TF, MMP expression, and adherence are highly relevant to cancer metastasis, this study suggests a novel mechanism of adaptation, thereby adding to the understanding of SCLC biology and its aggressiveness. Content Type Journal ArticleCategory Original ArticlePages 1-9DOI 10.1007/s00432-011-1139-1Authors Nicole Hahn, Division of Haematology and Transfusion Medicine, Paul-Ehrlich-Institut, Paul-Ehrlich-Straße 51-59, 63225 Langen, GermanyMargarethe Heiden, Division of Haematology and Transfusion Medicine, Paul-Ehrlich-Institut, Paul-Ehrlich-Straße 51-59, 63225 Langen, GermanyRainer Seitz, Division of Haematology and Transfusion Medicine, Paul-Ehrlich-Institut... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5596927 Wed, 11 Jan 2012 17:51:13 +0100 5596927 Tumorspheres derived from prostate cancer cells possess chemoresistant and cancer stem cell properties http://www.medworm.com/index.php?rid=5596928&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj2k188361v57r740%2F Conclusions  Collectively, these data demonstrated that tumorspheres derived from PCa cells possess chemoresistant and CSC properties. Our study suggests that the identification of PCa CSCs could provide new insight into the lethal phenotype of PCa and therapeutic implications. Content Type Journal ArticleCategory Original PaperPages 1-12DOI 10.1007/s00432-011-1146-2Authors Linlin Zhang, Department of Urology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061 ChinaMin Jiao, Department of Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaLei Li, Department of Urology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061 ChinaDapeng Wu, Department of Urology, The First Affiliated H... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5596928 Wed, 11 Jan 2012 17:51:12 +0100 5596928 Comparison of clinicopathological characteristics and prognoses between bilateral and unilateral breast cancer http://www.medworm.com/index.php?rid=5596930&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh93349m14l21q446%2F Conclusions  Bilateral cancer was associated with shorter disease-free survival and overall survival than unilateral cancer. The prognosis of metachronous bilateral cancer, especially those diagnosed within 2 years after the first cancer was significantly worse than synchronous bilateral cancer. Content Type Journal ArticleCategory Original PaperPages 1-10DOI 10.1007/s00432-011-1141-7Authors Yan-Xia Shi, Department of Medical Oncology, Sun Yat-Sen University Cancer Center, 651 Dongfeng Road, East, Guangzhou, 510060 People’s Republic of ChinaQing Xia, Department of Medical Oncology, Sun Yat-Sen University Cancer Center, 651 Dongfeng Road, East, Guangzhou, 510060 People’s Republic of ChinaRou-Jun Peng, Department of Medical Oncology, Sun Yat-Sen University Can... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5596930 Wed, 11 Jan 2012 17:51:11 +0100 5596930 Circulating microRNA-218 was reduced in cervical cancer and correlated with tumor invasion http://www.medworm.com/index.php?rid=5596929&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9785x37577064116%2F Conclusions  microRNA-218 was deregulated in most cervical cancer patients and associated with tumor invasion. Content Type Journal ArticleCategory Original PaperPages 1-4DOI 10.1007/s00432-012-1147-9Authors Jinjin Yu, Department of Obstetrics and Gynecology, The Fourth Affiliated Hospital of Suzhou University, Huihe Road No. 200, Binhu District, Wuxi, 214062 People’s Republic of ChinaYuan Wang, Department of Obstetrics and Gynecology, The Fourth Affiliated Hospital of Suzhou University, Huihe Road No. 200, Binhu District, Wuxi, 214062 People’s Republic of ChinaRuofan Dong, Department of Obstetrics and Gynecology, The Fourth Affiliated Hospital of Suzhou University, Huihe Road No. 200, Binhu District, Wuxi, 214062 People’s Republic of ChinaXiaoyan Huang, Department... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5596929 Wed, 11 Jan 2012 17:51:11 +0100 5596929 Overexpression of tumor suppressor TSLC1 by a survivin-regulated oncolytic adenovirus significantly inhibits hepatocellular carcinoma growth http://www.medworm.com/index.php?rid=5596932&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg7156148m6g328tk%2F Conclusion  These data suggest that an oncolytic adenovirus expressing TSLC1 is effective and support that SD55-TSLC1 may be a potent antitumoral agent for future clinical trials of liver cancer. Content Type Journal ArticleCategory Original ArticlePages 1-14DOI 10.1007/s00432-011-1138-2Authors Guoqing He, Xinyuan Institute of Medicine and Biotechnology, School of Life Sciences, Zhejiang Sci-Tech University, No. 2 Road Xiasha District, Hangzhou, 310018 ChinaWen Lei, Xinyuan Institute of Medicine and Biotechnology, School of Life Sciences, Zhejiang Sci-Tech University, No. 2 Road Xiasha District, Hangzhou, 310018 ChinaShibin Wang, Xinyuan Institute of Medicine and Biotechnology, School of Life Sciences, Zhejiang Sci-Tech University, No. 2 Road Xiasha District, Hangzhou... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5596932 Wed, 11 Jan 2012 17:51:10 +0100 5596932 Efficacy and safety of vascular endothelial growth factor receptor tyrosine kinase inhibitors in patients with metastatic renal cell carcinoma and poor risk features http://www.medworm.com/index.php?rid=5596931&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq115l60113106913%2F Conclusions  VEGFR TKIs, especially sunitinib, are active and tolerated by mRCC patients with poor risk features. Content Type Journal ArticleCategory Original PaperPages 1-7DOI 10.1007/s00432-012-1148-8Authors Jae-Lyun Lee, Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-gu, Seoul, 138-736 KoreaInkeun Park, Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-gu, Seoul, 138-736 KoreaKwonoh Park, Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-gu, Seoul, 138-736 KoreaSeongjoon Park, Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olym... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5596931 Wed, 11 Jan 2012 17:51:10 +0100 5596931 Expression of tumor suppressor gene ING4 in ovarian carcinoma is correlated with microvessel density http://www.medworm.com/index.php?rid=5580998&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5x78261676705755%2F Conclusions  Loss of ING4 may promote microvessel formation and plays a role in facilitating the development of ovarian cancer. Although the specific mechanisms are not yet understood, our data suggest that ING4 may be a promising target for the treatment for ovarian cancer. Content Type Journal ArticleCategory Original PaperPages 1-9DOI 10.1007/s00432-011-1099-5Authors Yinglan Liu, Department of Obstetrics and Gynecology, First Affiliated Hospital of Harbin Medical University, Harbin, ChinaLiqian Yu, Department of Obstetrics and Gynecology, First Affiliated Hospital of Harbin Medical University, Harbin, ChinaYingwei Wang, Department of Pathology, First Affiliated Hospital of Harbin Medical University, Harbin, ChinaYaling Zhang, Department of Obstetrics and Gynecolog... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5580998 Sat, 07 Jan 2012 16:56:16 +0100 5580998 The tumor suppressor role of Src homology phosphotyrosine phosphatase 2 in hepatocellular carcinoma http://www.medworm.com/index.php?rid=5580999&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fyg602548034141n6%2F Conclusion  Shp2 is a tumor suppressor, and the decrease in Shp2 expression was a new prognostic marker in HCC. The oncogenic role of Shp2 was tissue specific, and the therapeutic target of human gene PTPN11 should be reconsidered. Content Type Journal ArticleCategory Original ArticlePages 1-10DOI 10.1007/s00432-011-1143-5Authors Chengying Jiang, Pathology Department, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853 ChinaFangke Hu, Medical College, Nankai University, 94 Weijin Road, Tianjin, 300071 ChinaYanhong Tai, Pathology Department, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853 ChinaJingli Du, Pathology Department, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853 ChinaBeibei Mao, Institute of Biophysics, Chinese Academy o... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5580999 Fri, 06 Jan 2012 16:43:47 +0100 5580999 Increased expression of CD147 and MMP-9 is correlated with poor prognosis of salivary duct carcinoma http://www.medworm.com/index.php?rid=5571950&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fex0g654r44003623%2F Conclusion  CD147 and MMP-9 expression is correlated with invasion, metastasis and shorter PFS/OS of SDC. Patients with high expression of CD147 and MMP-9 had poor prognosis than SDC patients with low expression. Content Type Journal ArticleCategory Original PaperPages 1-9DOI 10.1007/s00432-011-1142-6Authors Songlin Piao, Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001 Heilongjiang, People’s Republic of ChinaShu Zhao, Department of Medical Oncology, The Third Affiliated Hospital of Harbin Medical University, Harbin, 150081 Heilongjiang, People’s Republic of ChinaFulin Guo, Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001 ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5571950 Wed, 04 Jan 2012 06:59:32 +0100 5571950 Polymorphisms of peroxiredoxin 1, 2 and 6 are not associated with esophageal cancer http://www.medworm.com/index.php?rid=5571951&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fmwq4682u7h832156%2F Conclusions  Our data suggested that polymorphisms of Prdx 1, 2 and 6 were not associated with esophageal cancer. Content Type Journal ArticleCategory Original PaperPages 1-6DOI 10.1007/s00432-011-1119-5Authors Bo Zhang, Department of Medical Genetics, Third Military Medical University, Chongqing, ChinaKai Wang, Department of Medical Genetics, Third Military Medical University, Chongqing, ChinaGang He, Department of Medical Genetics, Third Military Medical University, Chongqing, ChinaXinying Guan, Department of Medical Genetics, Third Military Medical University, Chongqing, ChinaBotao Liu, Department of Medical Genetics, Third Military Medical University, Chongqing, ChinaYangbo Liu, Department of Medical Genetics, Third Military Medical University, Chongqing, ChinaYun Ba... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5571951 Wed, 04 Jan 2012 06:59:31 +0100 5571951 PDCD4 expression inversely correlated with miR-21 levels in gastric cancers http://www.medworm.com/index.php?rid=5571952&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh75509q316421270%2F Conclusions  Our data suggest that overexpression of miRNA-21 and reduced or loss of PDCD4 expression may play a role in the development and progression of gastric cancers. Content Type Journal ArticleCategory Original ArticlePages 1-9DOI 10.1007/s00432-011-1140-8Authors Zhang Cao, Department of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, 137-701 KoreaJung Hwan Yoon, Department of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, 137-701 KoreaSuk Woo Nam, Department of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, 137-701 KoreaJung Young Lee, Department of Pathology, College of Medicine, The Catholic University... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5571952 Mon, 02 Jan 2012 16:46:38 +0100 5571952 miR-181a sensitizes resistant leukaemia HL-60/Ara-C cells to Ara-C by inducing apoptosis http://www.medworm.com/index.php?rid=5559427&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F07830718738145t2%2F Conclusions  This study for the first time demonstrated that downregulation of miR-181a and upregulation of Bcl-2 in leukaemia cells confer resistance to Ara-C-based therapy. These results suggest that restoration of miR-181a expression might provide a promising therapeutic in drug resistance of leukaemia. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s00432-011-1137-3Authors Haitao Bai, Department of Hematology, Shanghai Jiaotong University Affiliated Shanghai First People’s Hospital, Shanghai, ChinaZhongwei Cao, Department of Gastroenterology, Shanghai Jiaotong University Affiliated Shanghai First People’s Hospital, Shanghai, ChinaChong Deng, Department of Radiation Oncology, First Affiliated Hospital of Xiamen University, Fujian, Ch... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5559427 Sat, 31 Dec 2011 06:37:14 +0100 5559427 Combination of a MDR1-targeted replicative adenovirus and chemotherapy for the therapy of pretreated ovarian cancer http://www.medworm.com/index.php?rid=5559428&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe19013334pvj0637%2F Conclusion  These preclinical data suggest that a fiber-modified adenovirus vector under the control of the MDR1 promoter represents a promising treatment strategy for platinum-pretreated ovarian cancer as a single agent or in combination with conventional anticancer drugs. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s00432-011-1135-5Authors Daniel T. Rein, Department of Obstetrics and Gynecology, University of Düsseldorf Medical Center, Moorenstrasse 5, 40225 Düsseldorf, GermanyAnne Volkmer, Department of Obstetrics and Gynecology, University of Düsseldorf Medical Center, Moorenstrasse 5, 40225 Düsseldorf, GermanyGerd Bauerschmitz, Department of Obstetrics and Gynecology, University of Düsseldorf Medical Center, Moorenstrasse 5, 402... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5559428 Sat, 31 Dec 2011 06:37:12 +0100 5559428 Tipifarnib and tanespimycin show synergic proapoptotic activity in U937 cells http://www.medworm.com/index.php?rid=5559429&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F406p043870r5q1t5%2F Conclusions  Our results suggest that the combination of R115777 + 17AAG could be useful in treating some of the hematological malignancies. Content Type Journal ArticleCategory Rapid CommunicationPages 1-8DOI 10.1007/s00432-011-1131-9Authors Katarzyna Krzykowska-Petitjean, Jagiellonian University Medical College, ul. Kopernika 7, 31-034 Kraków, PolandJędrzej Małecki, Jagiellonian University Medical College, ul. Kopernika 7, 31-034 Kraków, PolandAnna Bentke, Jagiellonian University Medical College, ul. Kopernika 7, 31-034 Kraków, PolandBarbara Ostrowska, Jagiellonian University Medical College, ul. Kopernika 7, 31-034 Kraków, PolandPiotr Laidler, Jagiellonian University Medical College, ul. Kopernika 7, 31-034 Kraków, Poland Journal Journal of Can... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5559429 Fri, 30 Dec 2011 16:42:01 +0100 5559429 Expression and prognosis of FOXO3a and HIF-1α in nasopharyngeal carcinoma http://www.medworm.com/index.php?rid=5559430&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj436588j25117577%2F Conclusions  Our results suggested that FOXO3a and HIF-1α may be considered to be important prognostic markers in nasopharyngeal carcinoma. Content Type Journal ArticleCategory Original PaperPages 1-9DOI 10.1007/s00432-011-1125-7Authors Zhu Shou, Department of Otolaryngology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Chongqing, 400016 People’s Republic of ChinaLi Lin, Department of Otolaryngology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Chongqing, 400016 People’s Republic of ChinaJia Liang, Department of Otolaryngology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Chongqing, 400016 People’s Republic of ChinaJing-Li Li, Department of Otolaryngology, T... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5559430 Fri, 30 Dec 2011 16:41:58 +0100 5559430 Receptor for activated C kinase 1 (RACK1): a regulator for migration and invasion in oral squamous cell carcinoma cells http://www.medworm.com/index.php?rid=5559432&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F502n292446366p60%2F Conclusion  Our results clearly showed the significance of RACK1-induced OSCC cell migration, invasion and adhesion, which could explain the underlined mechanism of the effect of the gene on metastasis and clinical outcome. Also, our results confirmed its role to be a prognostic indicator and a promising drug target for OSCC cell metastasis. Content Type Journal ArticleCategory Original PaperPages 1-9DOI 10.1007/s00432-011-1097-7Authors Jing Li, State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, No. 14, Sec.3, Renminnan Road, Chengdu, 610041 Sichuan, ChinaYu Guo, State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, No. 14, Sec.3, Renminnan Road, Chengdu, 610041 Sichuan, ChinaXiaodong ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5559432 Fri, 30 Dec 2011 06:49:27 +0100 5559432 MiR-181d acts as a tumor suppressor in glioma by targeting K-ras and Bcl-2 http://www.medworm.com/index.php?rid=5559431&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd62844221413w8xj%2F Conclusion  MiR-181d may act as a glioma suppressor by targeting K-ras and Bcl-2. Content Type Journal ArticleCategory Original PaperPages 1-12DOI 10.1007/s00432-011-1114-xAuthors Xie-Feng Wang, Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029 Jiangsu Province, People’s Republic of ChinaZhu-Mei Shi, Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029 Jiangsu Province, People’s Republic of ChinaXi-Rui Wang, Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029 Jiangsu Province, People’s Republic of ChinaLei Cao, Department of Neurosurgery, The First ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5559431 Fri, 30 Dec 2011 06:49:27 +0100 5559431 The functional MDM2 T309G genetic variant but not P53 Arg72Pro polymorphism is associated with risk of sarcomas: a meta-analysis http://www.medworm.com/index.php?rid=5552019&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ftlk7452880l27751%2F Conclusion  These results suggest that the functional MDM2 T309G genetic variant may play a more important role in carcinogenesis of sarcoma. Content Type Journal ArticleCategory Original PaperPages 1-7DOI 10.1007/s00432-011-1124-8Authors Xu Cai, Department of Orthopedics, Division of Surgery, Chinese PLA General Hospital, Beijing, ChinaMing Yang, College of Life Science and Technology, Beijing University of Chemical Technology, P. O. Box 53, Beijing, 100029 China Journal Journal of Cancer Research and Clinical OncologyOnline ISSN 1432-1335Print ISSN 0171-5216 (Source: Journal of Cancer Research and Clinical Oncology) Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5552019 Wed, 28 Dec 2011 16:45:26 +0100 5552019 Pharmacologic inhibition of mTOR antagonizes the cytotoxic activity of pemetrexed in non-small cell lung cancer http://www.medworm.com/index.php?rid=5552020&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq7k1227722335071%2F Conclusions  Rapalogues may suppress the antitumor activity of pemetrexed by slowing cell cycle progression. This should be considered when combining pemetrexed and mTOR inhibitors in NSCLC treatment. Content Type Journal ArticleCategory Original PaperPages 1-10DOI 10.1007/s00432-011-1123-9Authors Boyka Markova, Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, 45122 Essen, GermanyPatricia S. Hähnel, Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, 45122 Essen, GermanyStefan Kasper, Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, 45122 Essen, GermanyStephan Herbertz, Novartis Ph... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5552020 Tue, 27 Dec 2011 17:02:40 +0100 5552020 Down-regulation of PDCD4 expression is an independent predictor of poor prognosis in human renal cell carcinoma patients http://www.medworm.com/index.php?rid=5552022&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fym8tk83371x11516%2F Conclusion  PDCD4 expression strongly correlated to RCC stage, tumor grade, tumor metastasis and tumor-related death. PDCD4 expression was also appears to be a marker in RCC prognosis. Content Type Journal ArticleCategory Original PaperPages 1-7DOI 10.1007/s00432-011-1121-yAuthors Xiancheng Li, Department of Urology, First Affiliated Hospital of Dalian Medical University, 116011 Dalian, ChinaShiyong Xin, Department of Urology, First Affiliated Hospital of Dalian Medical University, 116011 Dalian, ChinaDeyong Yang, Department of Urology, First Affiliated Hospital of Dalian Medical University, 116011 Dalian, ChinaXiunan Li, Department of Urology, First Affiliated Hospital of Dalian Medical University, 116011 Dalian, ChinaZhongzhou He, Department of Urology, First Affili... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5552022 Tue, 27 Dec 2011 17:02:39 +0100 5552022 Mutational activation of FGFR3: no involvement in the development of renal cell carcinoma http://www.medworm.com/index.php?rid=5552021&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0q1226784202x1q1%2F Conclusion  Our results argue against an involvement of mutational activation of FGFR3 in the development of RCC. A recently described cystic renal dysplasia in a patient with thanatophoric dysplasia type 1 due to a germ line FGFR3 mutation might portend to an involvement of mutational FGFR3 activation in renal cyst formation, but this speculation needs further evaluation. Content Type Journal ArticleCategory Rapid CommunicationPages 1-3DOI 10.1007/s00432-011-1130-xAuthors C. G. Stoehr, Institute of Pathology, University Hospital Erlangen, Erlangen, GermanyR. Stoehr, Institute of Pathology, University Hospital Erlangen, Erlangen, GermanyA. Hartmann, Institute of Pathology, University Hospital Erlangen, Erlangen, GermanyF. Hofstaedter, Institute of Pathology, Universi... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5552021 Tue, 27 Dec 2011 17:02:39 +0100 5552021 Expressions of MAGE-A10 and MAGE-A11 in breast cancers and their prognostic significance: a retrospective clinical study http://www.medworm.com/index.php?rid=5544151&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk25h3u10015222j7%2F Conclusions  MAGE-A10 and MAGE-A11 are tumor-specific antigens, and MAGE-A11 expression probably is a potential poor prognostic factor for breast cancer patients. Content Type Journal ArticleCategory Original PaperPages 1-9DOI 10.1007/s00432-011-1122-xAuthors Yishui Lian, Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050017 Hebei, People’s Republic of ChinaMeixiang Sang, Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050017 Hebei, People’s Republic of ChinaChunyan Ding, Tumor Research Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050017 Hebei, People’s Republic of ChinaXinliang Zhou, Tumor Research Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuan... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5544151 Sat, 24 Dec 2011 16:44:49 +0100 5544151 Early versus late administration of pegfilgrastim after high-dose chemotherapy and autologous hematopoietic stem cell transplantation http://www.medworm.com/index.php?rid=5544152&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft78442nj70346036%2F Conclusion  In terms of neutrophil or platelet recovery after AHSCT, number and duration of febrile episodes, the use of i.v. antibiotics, early and late administration of pegfilgrastim are equally effective. Content Type Journal ArticleCategory Original PaperPages 1-5DOI 10.1007/s00432-011-1116-8Authors C. Kahl, Department of Hematology and Oncology, Klinikum Magdeburg, Birkenallee 34, 39130 Magdeburg, GermanyH. G. Sayer, Department for Internal Medicine II (Hematology and Oncology), University of Jena, Jena, GermanyA. Hinke, WiSP Research Institute, Langenfeld, GermanyM. Freund, 3rd Medical Department, University of Rostock, Rostock, GermanyJ. Casper, Department of Hematology and Oncology, Klinikum Oldenburg, Oldenburg, Germany Journal Journal of Cancer Resea... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5544152 Sat, 24 Dec 2011 16:44:48 +0100 5544152 ARNTL2 and SERPINE1: potential biomarkers for tumor aggressiveness in colorectal cancer http://www.medworm.com/index.php?rid=5544153&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F92q08u408182l750%2F Conclusion   ARNTL2 and SERPINE1 expression is increased in colorectal cancer and in a highly proliferative colon cancer cell line and is related to tumor invasiveness and aggressiveness. Content Type Journal ArticleCategory Original PaperPages 1-11DOI 10.1007/s00432-011-1126-6Authors Gianluigi Mazzoccoli, Division of Internal Medicine and Chronobiology Unit, IRCCS “Casa Sollievo della Sofferenza”, Research Hospital, San Giovanni Rotondo, FG, ItalyValerio Pazienza, Division and Laboratory of Gastroenterology, IRCCS “Casa Sollievo della Sofferenza”, Research Hospital, San Giovanni Rotondo, FG, ItalyAnna Panza, Division and Laboratory of Gastroenterology, IRCCS “Casa Sollievo della Sofferenza”, Research Hospital, San Giovanni Rotondo, FG, ItalyMaria Rosa Va... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5544153 Fri, 23 Dec 2011 16:53:47 +0100 5544153 Risk stratification of oral cancer patients using a combined prognostic factor including lymph node density and biomarker http://www.medworm.com/index.php?rid=5544155&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb2146tu46687378x%2F Conclusions  The LND was shown to be an independent prognostic factor in OSCC, and a combined factor including LND may be used for risk stratification of OSCC patients, which displayed the best performance. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s00432-011-1129-3Authors Ki-Yeol Kim, Oral Cancer Research Institute, College of Dentistry, Yonsei University, Seoul, 120-752 Republic of KoreaIn-Ho Cha, Oral Cancer Research Institute, College of Dentistry, Yonsei University, Seoul, 120-752 Republic of Korea Journal Journal of Cancer Research and Clinical OncologyOnline ISSN 1432-1335Print ISSN 0171-5216 (Source: Journal of Cancer Research and Clinical Oncology) Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5544155 Thu, 22 Dec 2011 12:49:38 +0100 5544155 Autocrine epidermal growth factor receptor ligand production and cetuximab response in head and neck squamous cell carcinoma cell lines http://www.medworm.com/index.php?rid=5544154&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk7m3266v88735r58%2F Conclusions  The results indicate that the expression of several EGFR ligands has to be used to predict sensitivity to cetuximab in HNSCC. This has to be further evaluated in clinical samples. Content Type Journal ArticleCategory Original PaperPages 1-9DOI 10.1007/s00432-011-1127-5Authors Goro Oshima, Department of Otorhinolaryngology, Head and Neck Surgery, Lund University, 221 85 Lund, SwedenJohan Wennerberg, Department of Otorhinolaryngology, Head and Neck Surgery, Lund University, 221 85 Lund, SwedenTakashi Yamatodani, Department of Otorhinolaryngology, Head and Neck Surgery, Lund University, 221 85 Lund, SwedenElisabeth Kjellén, Department of Otorhinolaryngology, Head and Neck Surgery, Hamamatsu University School of Medicine, Hamamatsu, 431-3192 JapanHiroyuki Mi... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5544154 Thu, 22 Dec 2011 12:49:38 +0100 5544154 Reliability of tumor primary cultures as a model for drug response prediction: expression profiles comparison of tissues versus primary cultures from colorectal cancer patients http://www.medworm.com/index.php?rid=5537459&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn648205833223x35%2F Conclusions  Response of primary tumor cells toward different drugs is not linearly associated to tumor tissues. Our results highlight the importance to account for the discrepancy in responses between the primary tumor cells and original counterparts in order to provide clinicians with important insights to improve selection of drugs for individual patients based on in vitro assays. Content Type Journal ArticleCategory Original PaperPages 1-20DOI 10.1007/s00432-011-1115-9Authors Gregory Lucien Bellot, Cancer Science Institute of Singapore (CSI), National University of Singapore, 28 Medical Drive #02-07, Singapore, 117456 SingaporeWei Han Tan, Department of Biochemistry, Centre for Life Science (CeLS), Yong Loo Lin School of Medicine, National University of Singapore... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5537459 Tue, 20 Dec 2011 16:47:08 +0100 5537459 Comparison of transcatheter arterial chemoembolization and microsphere embolization for treatment of unresectable hepatocellular carcinoma: a meta-analysis http://www.medworm.com/index.php?rid=5524117&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn216v28031280503%2F Conclusions  These data demonstrated that microsphere embolization treatment of patients with surgically unresectable HCC provided much better survival and treatment response than that of TACE. Content Type Journal ArticleCategory Original PaperPages 1-8DOI 10.1007/s00432-011-1117-7Authors Feng Xie, Department of Health Statistics, The Second Military Medical University, Shanghai, 200433 ChinaJiajie Zang, Department of Health Statistics, The Second Military Medical University, Shanghai, 200433 ChinaXiaojing Guo, Department of Health Statistics, The Second Military Medical University, Shanghai, 200433 ChinaFeng Xu, Department of Special Treatment and Liver Transplantation, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, 200438 ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5524117 Sat, 17 Dec 2011 16:43:45 +0100 5524117 RUNX3 is involved in caspase-3-dependent apoptosis induced by a combination of 5-aza-CdR and TSA in leukaemia cell lines http://www.medworm.com/index.php?rid=5524119&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv1n2978083g7g638%2F Conclusion  RUNX3 plays an important role in leukaemia cellular functions, and the induction of RUNX3-mediated effects may contribute to the therapeutic value of combination TSA and 5-aza-CdR treatment. Content Type Journal ArticleCategory Original PaperPages 1-11DOI 10.1007/s00432-011-1113-yAuthors Feng-Xian Zhai, Department of Hematology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510630 ChinaXiang-Fu Liu, Department of Hematology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510630 ChinaRui-Fang Fan, Department of Hematology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510630 ChinaZi-Jie Long, Department of Hematology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510630 ChinaZhi-... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5524119 Sat, 17 Dec 2011 16:43:44 +0100 5524119 Chromophobe renal cell carcinoma: analysis of 53 cases http://www.medworm.com/index.php?rid=5524118&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd254u81140665338%2F Conclusions  CRCC is an uncommon subtype of RCC, with a favorable prognosis. Chinese patients are seemingly younger at diagnosis. Prediction of prognosis is still difficult. Content Type Journal ArticleCategory Original PaperPages 1-4DOI 10.1007/s00432-011-1112-zAuthors Peng-Ju Zhao, Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Center, No. 8 Xishiku St, Xicheng District, Beijing, 100034 ChinaXiao-Peng Chen, Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Center, No. 8 Xishiku St, Xicheng District, Beijing, 100034 ChinaXue-Song Li, Department of Urology, Peking University First Hospital, Institute of Urology, Pekin... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5524118 Sat, 17 Dec 2011 16:43:44 +0100 5524118 Trends in incidence, tumour sites and tumour stages of oral and pharyngeal cancer in Northern Germany http://www.medworm.com/index.php?rid=5515045&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F216185646j074544%2F Conclusions  Detailed population-based results described important variations with regard to tumour sites, stages and areas. These data play a central role as they provide the epidemiological profile of a tumour. This profile, together with possible targeted knowledge evaluations of the public and the health care providers involved, can be used as a prerequisite for health care activities and for the development of preventive strategies for targeted public awareness campaigns. Content Type Journal ArticleCategory Original PaperPages 1-7DOI 10.1007/s00432-011-1118-6Authors Katrin Hertrampf, Clinic of Oral and Maxillofacial Surgery, University Hospital of Schleswig–Holstein, Campus Kiel, Arnold-Heller Str.3, Haus 26, 24105 Kiel, GermanyJörg Wiltfang, Clinic of Oral... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5515045 Tue, 13 Dec 2011 17:05:37 +0100 5515045 Etoposide, vincristine, doxorubicin and dexamethasone (EVAD) combination chemotherapy as second-line treatment for advanced AIDS-related Kaposi’s sarcoma http://www.medworm.com/index.php?rid=5494591&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0q440h8173522151%2F Conclusions Combination chemotherapy with EVAD offers a new, active and safe therapeutic approach for the treatment of advanced AIDS-related KS. Content Type Journal ArticleCategory Original PaperPages 1-6DOI 10.1007/s00432-011-1109-7Authors Dong Ta Zhong, Department of Medical Oncology, Fujian Medical University Union Hospital, No. 29 Xinquan Road, Fuzhou, 350001 Fujian, People’s Republic of ChinaChun Mei Shi, Department of Medical Oncology, Fujian Medical University Union Hospital, No. 29 Xinquan Road, Fuzhou, 350001 Fujian, People’s Republic of ChinaQiang Chen, Department of Medical Oncology, Fujian Medical University Union Hospital, No. 29 Xinquan Road, Fuzhou, 350001 Fujian, People’s Republic of ChinaJing Ze Huang, Department of Medicine, Fujian Medical University Un... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5494591 Sat, 10 Dec 2011 16:55:20 +0100 5494591 Inhibition of Aurora kinases enhances chemosensitivity to temozolomide and causes radiosensitization in glioblastoma cells http://www.medworm.com/index.php?rid=5494593&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe6t465424w166tq1%2F Conclusions  These data suggest that Aurora kinase inhibition may be a target for glioblastoma treatment and could be used as adjuvant to chemo- and radiotherapy. Content Type Journal ArticleCategory Original PaperPages 1-10DOI 10.1007/s00432-011-1111-0Authors Kleiton Silva Borges, Department of Genetics, School of Medicine of Ribeirão Preto, University of São Paulo (USP), Avenida Bandeirantes 3900, Ribeirão Preto, SP 14048-900, BrazilAngel Maurício Castro-Gamero, Department of Genetics, School of Medicine of Ribeirão Preto, University of São Paulo (USP), Avenida Bandeirantes 3900, Ribeirão Preto, SP 14048-900, BrazilDaniel Antunes Moreno, Department of Genetics, School of Medicine of Ribeirão Preto, University of São Paulo (USP), Avenida Bandeirantes 3900, R... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5494593 Thu, 08 Dec 2011 18:22:06 +0100 5494593 Thoracic neoplasms at the Jena reference center for soft tissue tumors http://www.medworm.com/index.php?rid=5494592&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F727m075u8q500286%2F Conclusions  Our study provides information about the frequency, distribution, age and gender of patients with thoracic soft tissue tumors including several rare entities. Thus, it may help in the differential diagnosis of these neoplasms. In addition, we present a model highlighting the potential progression of lung carcinoma to undifferentiated sarcoma via the process of epithelial–mesenchymal transition. Content Type Journal ArticleCategory Original PaperPages 1-10DOI 10.1007/s00432-011-1108-8Authors Kathrin Nitsche, Institute of Pathology, Universitätsklinikum Jena, Ziegelmühlenweg 1, 07740 Jena, GermanyBianka Günther, Institute of Pathology, Universitätsklinikum Jena, Ziegelmühlenweg 1, 07740 Jena, GermanyDetlef Katenkamp, Institute of Pathology, Univers... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5494592 Thu, 08 Dec 2011 18:22:06 +0100 5494592 High KIT and PDGFRA are associated with shorter patients survival in gastroenteropancreatic neuroendocrine tumors, but mutations are a rare event http://www.medworm.com/index.php?rid=5486432&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe21874q80gh58350%2F Conclusions  High expression of KIT and PDGFRA was significantly correlated with shorter patients survival and could serve as prognostic marker. Mutations of the KIT gene might open new avenues for tyrosine kinase inhibitor therapy in a subset of patients with advanced pancreatic neuroendocrine tumors. Content Type Journal ArticleCategory Original PaperPages 1-7DOI 10.1007/s00432-011-1107-9Authors Thomas Knösel, Institute of Pathology, Friedrich-Schiller University, Jena University Hospital, Ziegelmühlenweg 1, 07743 Jena, GermanyYuan Chen, Institute of Pathology, Friedrich-Schiller University, Jena University Hospital, Ziegelmühlenweg 1, 07743 Jena, GermanyAnnelore Altendorf-Hofmann, Department of General, Visceral and Vascular Surgery, Friedrich-Schiller Universi... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5486432 Wed, 07 Dec 2011 12:54:25 +0100 5486432 Possible predictors of histopathological response to neoadjuvant chemoradiotherapy for rectal cancer http://www.medworm.com/index.php?rid=5486433&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk70565012k4216xx%2F Conclusions  GHRH-R and Hsp90 were found to be independent predictive factors of histopathological response to neoadjuvant RCT. Since GHRH-R antagonists and Hsp90 inhibitors are currently being tested as potential anticancer agents, our study implies the possible elaboration of an effective and individualized treatment of poor responders. Content Type Journal ArticleCategory Original PaperPages 1-9DOI 10.1007/s00432-011-1110-1Authors Robert Farkas, Department of Oncology, University of Pécs, Edesanyak street 17, 7624 Pecs, HungaryEva Pozsgai, Department of Biochemistry and Medical Chemistry, University of Pécs, Pecs, HungaryAndrew V. Schally, Veterans Affairs Medical Center and South Florida Veterans Affairs Foundation for Research and Education, Miami, FL, USAAndr... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5486433 Wed, 07 Dec 2011 12:54:20 +0100 5486433 Roles of genetic variants in the PI3K and RAS/RAF pathways in susceptibility to endometrial cancer and clinical outcomes http://www.medworm.com/index.php?rid=5486434&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fkt45636704677606%2F Conclusion  These results suggest that common genetic variations in these pathways may modulate risk and clinical outcomes of endometrial cancer. Further replication and functional studies are needed to confirm these findings. Content Type Journal ArticleCategory Original PaperPages 1-9DOI 10.1007/s00432-011-1103-0Authors Li-E Wang, Department of Epidemiology, Unit 1365, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USAHongxia Ma, Department of Epidemiology, Unit 1365, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USAKatherine S. Hale, Department of Systems Biology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USAMing Yin, Department of Epidemiology, U... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5486434 Tue, 06 Dec 2011 17:01:19 +0100 5486434 Functional outcome after different oncological interventions in head and neck cancer patients http://www.medworm.com/index.php?rid=5486435&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6148336337154t60%2F Conclusions  Although both treatment options (surgery and surgery with radiotherapy) were performed according to the tumor stage of patients, there are significant differences in the functional outcome of these patients as observed in this study. There is a lack of a measuring instrument that will be the “gold standard” in the assessment of head and neck functional mobility. This study will allow the reflection of our current practice and may stimulate further well-designed prospective studies. Content Type Journal ArticleCategory Original PaperPages 1-6DOI 10.1007/s00432-011-1106-xAuthors Thomas Mücke, Department of Oral and Maxillofacial Surgery, Klinikum Rechts der Isar der, Technischen Universität München, Ismaninger Str. 22, 81675 Munich, GermanyJanett K... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5486435 Mon, 05 Dec 2011 17:35:52 +0100 5486435 The antitumor effect of mesenchymal stem cells transduced with a lentiviral vector expressing cytosine deaminase in a rat glioma model http://www.medworm.com/index.php?rid=5476147&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj6721rv8027ujv75%2F Conclusion  Genetically engineered MSCs have good therapeutic efficacy against experimental gliomas in rats. Content Type Journal ArticleCategory Original PaperPages 1-11DOI 10.1007/s00432-011-1104-zAuthors Song Fei, Department of Neurosurgery, Second Hospital Affiliated to Dalian Medical University, Dalian, 116027 ChinaXing Qi, Department of Anesthesia, First Hospital Affiliated to Dalian Medical University, Dalian, 116011 ChinaSong Kedong, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian, 116024 ChinaJi Guangchun, Department of Neurosurgery, Second Hospital Affiliated to Dalian Medical University, Dalian, 116027 ChinaLiu Jian, Department of Neurosurgery, Second Hospital Affiliated to Dalian Medical University, Dalian, 1160... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5476147 Sat, 03 Dec 2011 16:49:40 +0100 5476147 Oral tongue cancer patients show a better overall survival than base of tongue cancer patients http://www.medworm.com/index.php?rid=5476148&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2q4555130g628352%2F Conclusion  The oral tongue cancer patients had a better prognosis than base of tongue cancer patients. The difference in prognosis between the oral tongue cancer and the base of tongue cancer patients in this study was closely associated with the recurrence and regional lymph node metastasis. We conclude that the individual treatment should be used for base of tongue cancer patients. Content Type Journal ArticleCategory Original PaperPages 1-6DOI 10.1007/s00432-011-1105-yAuthors Liuyang Zhang, The First Department of Head and Neck, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Huanhuxi Road, Tiyuanbei, Hexi District, Tianjin, 300060 ChinaXuan Zhou, The First Department of Head and Neck, Key Laboratory of C... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5476148 Fri, 02 Dec 2011 18:07:54 +0100 5476148 Evaluation of oral chemotherapy with capecitabine and cyclophosphamide plus thalidomide and prednisone in prostate cancer patients http://www.medworm.com/index.php?rid=5476150&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa25563g22gn57170%2F Conclusions  These data suggested that oral combination second-line chemotherapy with capecitabine and CTX plus thalidomide and prednisone offers promising activity with an excellent safety profile for patients with advanced CRPC. Content Type Journal ArticleCategory Original PaperPages 1-7DOI 10.1007/s00432-011-1101-2Authors Li-Juan Meng, Department of Hematology and Oncology, Jiangsu Province Geriatric Institute, 30 Luojia Road, Nanjing, Jiangsu 210024, People’s Republic of ChinaJun Wang, Department of Hematology and Oncology, Jiangsu Province Geriatric Institute, 30 Luojia Road, Nanjing, Jiangsu 210024, People’s Republic of ChinaWei-Fei Fan, Department of Hematology and Oncology, Jiangsu Province Geriatric Institute, 30 Luojia Road, Nanjing, Jiangsu 210024, Peo... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5476150 Thu, 01 Dec 2011 19:27:16 +0100 5476150 Shorter disease-specific survival of ER-positive breast cancer patients with high cytoplasmic Src kinase expression after tamoxifen treatment http://www.medworm.com/index.php?rid=5476149&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft61332x8r1506017%2F Conclusions  No translational evidence was found in this study to support a role for Src kinase in developing de novo tamoxifen resistance. However, based on our findings on late clinical outcome, patients with high cytoplasmic c-Src may be selected for continuing endocrine therapy to prevent worsening prognosis. Content Type Journal ArticleCategory Original PaperPages 1-6DOI 10.1007/s00432-011-1096-8Authors B. Elsberger, Institute of Cancer, College of Medical, Veterinary and Life Sciences, University of Glasgow, Western Infirmary, McGregor Building, Dumbarton Road, Glasgow, G11 6NT UKD. M. Paravasthu, Institute of Cancer, College of Medical, Veterinary and Life Sciences, University of Glasgow, Western Infirmary, McGregor Building, Dumbarton Road, Glasgow, G11 6NT U... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5476149 Thu, 01 Dec 2011 19:27:16 +0100 5476149 Histone deacetylase inhibitor potentiates chemotherapy-induced apoptosis through Bim upregulation in Burkitt’s lymphoma cells http://www.medworm.com/index.php?rid=5476151&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk0233310g5502685%2F Conclusions  The study provides strong evidence for the synergistic effects of the association with HDCI and chemotherapy in BL cells. Content Type Journal ArticleCategory Original PaperPages 1-9DOI 10.1007/s00432-011-1093-yAuthors Ana Carolina dos Santos Ferreira, Programa de Pesquisa em Hemato-Oncologia Molecular, Coordenação Geral Técnico-Científica, Instituto Nacional de Câncer-INCA, Rio de Janeiro, BrazilRenan Amphilophio Fernandes, Programa de Pesquisa em Hemato-Oncologia Molecular, Coordenação Geral Técnico-Científica, Instituto Nacional de Câncer-INCA, Rio de Janeiro, BrazilJolie Kiemlian Kwee, Programa de Pesquisa em Hemato-Oncologia Molecular, Coordenação Geral Técnico-Científica, Instituto Nacional de Câncer-INCA, Rio de Janeiro, BrazilClaudete ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5476151 Wed, 30 Nov 2011 18:42:27 +0100 5476151 The role of leptin receptor gene polymorphisms in determining the susceptibility and prognosis of NSCLC in Chinese patients http://www.medworm.com/index.php?rid=5468405&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj3745002251507v5%2F Conclusion  The results suggest the polymorphisms of Gln223Arg, rather than Lys109Arg and Lys656Asn, may be used as a molecular marker for progression and prognosis of NSCLC. Content Type Journal ArticleCategory Original PaperPages 1-6DOI 10.1007/s00432-011-1098-6Authors Yuliang Li, Second Affiliated Hospital of Shandong University, BeiYuan Road 247, Jinan city, 250033 Shandong province, People’s Republic of ChinaJianli Geng, Municipal Hospital of Wei Hai, Shandong University, He Ping Road 70, Wei Hai, Shandong province, People’s Republic of ChinaYongzheng Wang, Second Affiliated Hospital of Shandong University, BeiYuan Road 247, Jinan city, 250033 Shandong province, People’s Republic of ChinaQinghua Lu, Second Affiliated Hospital of Shandong University, BeiYuan... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5468405 Wed, 30 Nov 2011 04:53:08 +0100 5468405 Palliative considerations in the surgical treatment of spinal metastases http://www.medworm.com/index.php?rid=5468406&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fhk2mn9682227856p%2F Conclusions  Palliative surgical treatment for metastatic spinal tumors using a decompressive posterolateral approach combined with sole posterior instrumentation achieved convincing clinical results. All patients with intractable pain showed significant improvement postoperatively, and neurological deterioration was avoided. Since patients with spinal metastases enter the terminal stage of their disease, it is generally agreed that they require only palliative surgical treatments. Accordingly, spinal decompression and stabilization may be performed to improve the quality of the remaining life of cancer patients. Content Type Journal ArticleCategory Original PaperPages 1-10DOI 10.1007/s00432-011-1100-3Authors Jan Walter, Department of Neurosurgery, Jena University ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5468406 Wed, 30 Nov 2011 04:53:05 +0100 5468406 Hox B4 as potential marker of non-differentiated cells in human cervical cancer cells http://www.medworm.com/index.php?rid=5456978&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F112vm070383g2631%2F Conclusions  Hox B4 protein is present in the precursor lesions as CC cells, suggesting that Hox B4 could be a protein related to the neoplastic state (non-differentiated cells) of human cervical epithelium. Content Type Journal ArticleCategory Original PaperPages 1-8DOI 10.1007/s00432-011-1081-2Authors Ana P. Barba-de la Rosa, Division de Biologia Molecular, Instittuto Potosino de Investigacion, Ciencia y Tecnologia, Mexico, SLP, MexicoErika Briones-Cerecero, Division de Biologia Molecular, Instittuto Potosino de Investigacion, Ciencia y Tecnologia, Mexico, SLP, MexicoOfelia Lugo-Melchor, Division de Biologia Molecular, Instittuto Potosino de Investigacion, Ciencia y Tecnologia, Mexico, SLP, MexicoAntonio De León-Rodríguez, Division de Biologia Molecular, Instittut... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5456978 Sat, 26 Nov 2011 16:48:44 +0100 5456978 High serum HER2 extracellular domain levels: correlation with a worse disease-free survival and overall survival in primary operable breast cancer patients http://www.medworm.com/index.php?rid=5449519&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa125575820477394%2F Conclusion  Serum HER2 ECD level can reflect tissue HER2 status and can be an independent prognostic indicator for primary operable breast cancer patients. Content Type Journal ArticleCategory Original PaperPages 1-10DOI 10.1007/s00432-011-1095-9Authors Yanan Kong, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong 510060, People’s Republic of ChinaShuqin Dai, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong 510060, People’s Republic of ChinaXinhua Xie, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong 510060, People’s Republic of ChinaXiangsheng Xiao, State Key Laboratory of Oncology in Sou... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5449519 Thu, 24 Nov 2011 17:53:36 +0100 5449519 Second-line epidermal growth factor receptor inhibitors followed by third-line pemetrexed or the reverse sequence: a retrospective analysis of 83 Chinese patients with advanced lung adenocarcinoma http://www.medworm.com/index.php?rid=5449518&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb4t81242m0r16711%2F Conclusions  We hypothesized that for EGFR-mutated patients, second-line EGFR TKIs followed by third-line pemetrexed is preferable to the reverse sequence. Content Type Journal ArticleCategory Original PaperPages 1-7DOI 10.1007/s00432-011-1084-zAuthors Tingting Hong, Department of Medical Oncology, Fourth Affiliated Hospital of Suzhou University, Huihe Road 200, Wuxi, 214062 People’s Republic of ChinaRuxia Zhang, Department of Medical Oncology, Fourth Affiliated Hospital of Suzhou University, Huihe Road 200, Wuxi, 214062 People’s Republic of ChinaDongyan Cai, Department of Medical Oncology, Fourth Affiliated Hospital of Suzhou University, Huihe Road 200, Wuxi, 214062 People’s Republic of ChinaXiaohong Wu, Department of Medical Oncology, Fourth Affiliated Hospita... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5449518 Thu, 24 Nov 2011 17:53:36 +0100 5449518 Growth pattern of renal cell carcinoma (RCC) in patients with delayed surgical intervention http://www.medworm.com/index.php?rid=5440334&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fyk75u853120m1131%2F Conclusions  RCCs were found to be slow growing in a group of untreated renal cell carcinoma patients. However, some tumors progressed in stage under observation. The growth rate of RCC tended to correlate with histologic grade and histologic subtype. Content Type Journal ArticleCategory Original PaperPages 1-6DOI 10.1007/s00432-011-1083-0Authors Xue-Song Li, Department of Urology, First Hospital of Peking University, Institute of Urology, Peking University, National Urological Cancer Center, No. 8 Xishiku St, Xicheng District, Beijing, 100034 ChinaLin Yao, Department of Urology, First Hospital of Peking University, Institute of Urology, Peking University, National Urological Cancer Center, No. 8 Xishiku St, Xicheng District, Beijing, 100034 ChinaKan Gong, Department ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5440334 Mon, 21 Nov 2011 18:09:32 +0100 5440334 Nodal status—its impact on prognosis in advanced ovarian cancer http://www.medworm.com/index.php?rid=5440335&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F77g27t9272721350%2F Conclusion  Main intention of primary surgery is R0 resection with best prognosis in advanced stages. A systematic lymphadenectomy in cases with R0 resection or residual tumor <1 cm seems to be reasonable with positive impact on prognosis. Node status has impact on prognosis in patients with negative node after R0 resection with best PFS in FIGO III. Further prospective studies had to show whether systematic lymphadenectomy in suboptimally tumor-reduced patients can improve prognosis. Content Type Journal ArticleCategory Original PaperPages 1-7DOI 10.1007/s00432-011-1094-xAuthors C. Bachmann, Department of Gynecology and Obstetrics, University of Tübingen, Calwer Str. 7, 72070 Tübingen, GermanyS. Bachmann, Department of Gynecology and Obstetrics, University... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5440335 Mon, 21 Nov 2011 18:09:31 +0100 5440335 Intensity-modulated radiotherapy combined with chemotherapy for the treatment of gastric cancer patients after standard D1/D2 surgery http://www.medworm.com/index.php?rid=5440336&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fnx15241832v10221%2F Conclusions  Our findings indicate that CCRT can increase the one-, two-, and three-year total survival rates, as well as the disease-free survival rates of gastric cancer patients (T3/T4 and/or N+) who have been initially treated with surgery. The major adverse reactions were Grade I and Grade II nausea and vomiting, as well as myelosuppression. CCRT is well tolerated. Content Type Journal ArticleCategory Original PaperPages 1-5DOI 10.1007/s00432-011-1085-yAuthors Changhua Yu, Department of Radiotherapy, The First People’s Hospital in Huai’an, Huai’an, 223300 ChinaRen Yu, Department of Radiotherapy, The First People’s Hospital in Huai’an, Huai’an, 223300 ChinaWeiguo Zhu, Department of Radiotherapy, The First People’s Hospital in Huai’an, Huai’an, 2... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5440336 Mon, 21 Nov 2011 18:09:29 +0100 5440336 ARK5 is associated with the invasive and metastatic potential of human breast cancer cells http://www.medworm.com/index.php?rid=5440337&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm645618422382327%2F Conclusion  ARK5 led to a more invasive phenotype and metastatic potential in human breast cancer dependent on Akt. Content Type Journal ArticleCategory Original PaperPages 1-8DOI 10.1007/s00432-011-1102-1Authors Xin-Zhong Chang, Tianjin Medical University, Cancer Institute and Hospital, Tianjin, 300060 People’s Republic of ChinaJie Yu, Weifang University, Weifang, 261041 People’s Republic of ChinaHai-Yin Liu, Weifang People’s Hospital, Weifang, 261041 People’s Republic of ChinaRui-Hua Dong, Weifang People’s Hospital, Weifang, 261041 People’s Republic of ChinaXu-Chen Cao, Tianjin Medical University, Cancer Institute and Hospital, Tianjin, 300060 People’s Republic of China Journal Journal of Cancer Research and Clinical OncologyOnline ISSN 1432-1335Pr... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5440337 Mon, 21 Nov 2011 18:09:28 +0100 5440337 The SUVmax (maximum standardized uptake value for F-18 fluorodeoxyglucose) and serum squamous cell carcinoma antigen (SCC-ag) function as prognostic biomarkers in patients with primary cervical cancer http://www.medworm.com/index.php?rid=5431346&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F404063116k5v1331%2F Conclusions  Higher pretreatment SUVmax of primary tumor indicated worse prognosis, and the prognosis of patients with higher pretreatment SUVmax plus PLN metastasis was even worse both in patients of squamous cell carcinoma (SCC) and non-SCC of cervix. As for patients with SCC of cervix, higher pretreatment serum SCC-ag not only predicted worse prognosis but also predicted disease recurrence in the posttreatment surveillance. Content Type Journal ArticleCategory Original PaperPages 1-8DOI 10.1007/s00432-011-1092-zAuthors LingLing Pan, Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai, 200032 ChinaJingYi Cheng, Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai, 200032 ChinaMin Zhou, Department of Nuclea... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5431346 Sat, 19 Nov 2011 16:51:40 +0100 5431346 A C118T polymorphism of ERCC1 and response to cisplatin chemotherapy in patients with late-stage non-small cell lung cancer http://www.medworm.com/index.php?rid=5431347&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk013244710784302%2F Conclusions  Our results suggest that this polymorphism of ERCC1 at codon 118 is associated with patient response to cisplatin-based chemotherapy in treatments of late-stage NSCLC. Moreover, by assaying this SNP in blood cells, the ERCC1 codon 118 may represent a valuable biomarker in developing individualized treatments for NSCLC patients. Content Type Journal ArticleCategory Original PaperPages 1-8DOI 10.1007/s00432-011-1090-1Authors Jian Cheng, Department of Oncology, First Affiliated Hospital of Liaoning Medical University, Jinzhou, 121000 ChinaMinwen Ha, Department of Oncology, First Affiliated Hospital of Liaoning Medical University, Jinzhou, 121000 ChinaYadi Wang, Department of Oncology, First Affiliated Hospital of Liaoning Medical University, Jinzhou, 121000... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5431347 Sat, 19 Nov 2011 16:51:39 +0100 5431347 Meta-analysis of phase III trials of docetaxel alone or in combination with chemotherapy in metastatic breast cancer http://www.medworm.com/index.php?rid=5431348&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe136438076p812v6%2F Conclusion  Combination chemotherapy regimens with docetaxel show a statistically significant advantage for TTP, but not for OS and ORR in MBC. This review confirms that it is unlikely that any single agent or combination chemotherapy regimen will emerge as superior in MBC, due to its heterogeneous nature. Content Type Journal ArticleCategory Original PaperPages 1-9DOI 10.1007/s00432-011-1091-0Authors Maurizio Belfiglio, Department of Clinical Pharmacology and Epidemiology, Consorzio Mario Negri Sud, Via Nazionale 8/A, Santa Maria Imbaro, Chieti, ItalyCaterina Fanizza, Department of Clinical Pharmacology and Epidemiology, Consorzio Mario Negri Sud, Via Nazionale 8/A, Santa Maria Imbaro, Chieti, ItalyNicola Tinari, Unit of Medical Oncology, Department of Oncology and ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5431348 Fri, 18 Nov 2011 06:58:20 +0100 5431348 Enhanced ABL-inhibitor-induced MAPK-activation in T315I-BCR-ABL-expressing cells: a potential mechanism of altered leukemogenicity http://www.medworm.com/index.php?rid=5421600&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fdmt4348536484j74%2F Conclusions  Aberrant MAPK-activation triggered by ABL-inhibitors and positively regulated by BCR-ABL kinase mutation T315I might be an experimental explanation for the clinical observation that patients carrying high-resistance mutations show a highly aggressive course of their disease when tyrosine kinase inhibitor treatment is not discontinued in time. Content Type Journal ArticleCategory Original PaperPages 1-10DOI 10.1007/s00432-011-1086-xAuthors Nicolai Härtel, III. Medizinische Universitätsklinik, Universitätsmedizin Mannheim der Universität Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, GermanyThomas Klag, Klinik f. Innere Medizin II, Abt. f. Hämatologie/Onkologie, Universitätsklinikum Jena, Erlanger Allee 101, 07740 Jena, GermanyBenjamin Hanfstei... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5421600 Wed, 16 Nov 2011 16:45:24 +0100 5421600 PAX3/7–FOXO1 fusion status in older rhabdomyosarcoma patient population by fluorescent in situ hybridization http://www.medworm.com/index.php?rid=5421601&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4811246742052582%2F Conclusions  Therefore, identification of a FOXO1 fusion appears to be an interesting tool for predicting outcomes in older rhabdomyosarcoma patients and is worth further investigations in this rare subgroup of RMS population. Content Type Journal ArticleCategory Original PaperPages 1-8DOI 10.1007/s00432-011-1089-7Authors Sarah N. Dumont, Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77054, USAAlexander J. Lazar, Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USAJulia A. Bridge, Department of Pathology and Microbiology, University of Nebraska Medical Center, 989550 Nebraska Medical Center, Omaha, NE 68198, USARobert... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5421601 Wed, 16 Nov 2011 16:45:21 +0100 5421601 Downregulation of EphA2 expression suppresses the growth and metastasis in squamous-cell carcinoma of the head and neck in vitro and in vivo http://www.medworm.com/index.php?rid=5421602&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0682t10573516x21%2F Conclusions  These results suggest that EphA2 plays a critical role in SCCHN growth and metastasis and may be a promising therapeutic target to prevent the progression of SCCHN. Content Type Journal ArticleCategory Original PaperPages 1-8DOI 10.1007/s00432-011-1087-9Authors Yong Liu, Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Xiangya Road 87, Changsha, 410008 Hunan Province, People’s Republic of ChinaChangyun Yu, Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Xiangya Road 87, Changsha, 410008 Hunan Province, People’s Republic of ChinaYuanzheng Qiu, Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Xiangya Road 87, Chan... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5421602 Tue, 15 Nov 2011 16:57:02 +0100 5421602 Histopathology of surgically treated renal tumours in young adults: a developing country perspective http://www.medworm.com/index.php?rid=5421603&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F26624502r553u023%2F Conclusion  A wide variety of renal tumours is documented in young adults with large size of the tumours and late presentation in our population. Content Type Journal ArticleCategory Original PaperPages 1-6DOI 10.1007/s00432-011-1082-1Authors Muhammed Mubarak, Histopathology Department, Sindh Institute of Urology and Transplantation (SIUT), Karachi, 74200 PakistanJaved I. Kazi, Histopathology Department, Sindh Institute of Urology and Transplantation (SIUT), Karachi, 74200 PakistanRehan Mohsin, Urology Department, Sindh Institute of Urology and Transplantation (SIUT), Karachi, PakistanAltaf Hashmi, Urology Department, Sindh Institute of Urology and Transplantation (SIUT), Karachi, PakistanSyed Ali Anwer Naqvi, Urology Department, Sindh Institute of Urology and Transpl... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5421603 Tue, 15 Nov 2011 06:49:14 +0100 5421603 Aberrant expression of intelectin-1 in gastric cancer: its relationship with clinicopathological features and prognosis http://www.medworm.com/index.php?rid=5421604&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd1h52v5803628857%2F Conclusion  The aberrant ITLN-1 expression in gastric cancer is correlated with clinicopathological features and may be a useful prognostic factor for predicting the outcomes of gastric cancer patients. Content Type Journal ArticleCategory Original PaperPages 1-10DOI 10.1007/s00432-011-1088-8Authors Liduan Zheng, Department of Pathology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022 Hubei Province, People’s Republic of ChinaMixia Weng, Department of Pathology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022 Hubei Province, People’s Republic of ChinaMeng Qi, Department of Surgery, Union Hospital of Tongji Medical College, Huazhong University of Science an... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5421604 Mon, 14 Nov 2011 16:53:27 +0100 5421604 Up-regulation of microRNA-155 promotes cancer cell invasion and predicts poor survival of hepatocellular carcinoma following liver transplantation http://www.medworm.com/index.php?rid=5407114&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm23q0m6v0625w645%2F Conclusions  MicroRNA-155 is a candidate oncogenic microRNA and plays an important role in promoting HCC cells invasion. Our findings suggest that microRNA-155 may serve as a novel biomarker for tumor recurrence and survival of HCC patients following OLT. Content Type Journal ArticleCategory Original PaperPages 1-9DOI 10.1007/s00432-011-1076-zAuthors Zhong-Bo Han, Department of General Surgery, Shanghai First People’s Hospital, School of Medicine, Shanghai Jiao Tong University, 100 Haining Road, Shanghai, 200080 ChinaHong-Yuan Chen, Department of General Surgery, Shanghai First People’s Hospital, School of Medicine, Shanghai Jiao Tong University, 100 Haining Road, Shanghai, 200080 ChinaJun-Wei Fan, Department of General Surgery, Shanghai First People’s Hospital,... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5407114 Wed, 09 Nov 2011 17:56:01 +0100 5407114 Expression of coagulation factors and their receptors in tumor tissue and coagulation factor upregulation in peripheral blood of patients with cerebral carcinoma metastases http://www.medworm.com/index.php?rid=5407115&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0000q61l2423846n%2F Conclusions  These observations support the hypothesis of a link between the hemostatic system in the periphery and the malignant tumor disease even when the tumor is an intracerebral metastasis and the affected patient currently is free of a systemically active tumor. The results of this study support the hypothesis that the concerted action of coagulation factors and their receptors within the metastasis tissue itself and the systemic coagulation system could control the malignant behavior of tumor disease and make larger prospective trials mandatory. Content Type Journal ArticleCategory Original PaperPages 1-11DOI 10.1007/s00432-011-1078-xAuthors Jan Walter, Department of Neurosurgery, Medical Center of Friedrich-Schiller-University, University Hospital Jena, Er... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5407115 Mon, 07 Nov 2011 17:11:41 +0100 5407115 The effects of vascular endothelial growth factor C knockdown in esophageal squamous cell carcinoma http://www.medworm.com/index.php?rid=5384551&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fnp045305x551442w%2F Conclusions  The siRNA-targeted knockdown of VEGF-C led to a significant reduction in VEGF-C expression. This siRNA technique could be used for gene therapy in ESCC. Content Type Journal ArticleCategory Original PaperPages 1-7DOI 10.1007/s00432-011-1079-9Authors Hongxin Zhang, Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052 ChinaYuhui Yin, Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052 ChinaLan Zhang, Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052 ChinaXiangyu Zheng, Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052 ChinaDongling Gao, Department of Pathology, The First Aff... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5384551 Sat, 05 Nov 2011 17:10:38 +0100 5384551 How to determine post-RCHOP therapy for risk-tailored adult patients with diffuse large B-cell lymphoma, addition of maintenance rituximab or observation: multicenter experience http://www.medworm.com/index.php?rid=5384550&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx1h0785380378x3t%2F Conclusions  In conclusion, maintenance rituximab after RCHOP improves progression-free survival. In addition, overall survival is improved for patients with an IPI ≥3 risk profile receiving MR. Content Type Journal ArticleCategory Original PaperPages 1-8DOI 10.1007/s00432-011-1074-1Authors Bin-Tao Huang, Department of Hematology, The Affiliated Hospital of Inner Mongolia Medical College, 1 TongDao Avenue North, 010059 Hohhot, People’s Republic of ChinaQing-Chun Zeng, Department of Medicine, The Affiliated Hospital of Guangdong Medical College, 524001 Zhanjiang, People’s Republic of ChinaJessica Yu, Department of Surgery, University of Colorado School of Medicine, Aurora, CO 80045, USAZhen Xiao, Department of Hematology, The Affiliated Hospital of Inner Mongolia... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5384550 Sat, 05 Nov 2011 17:10:38 +0100 5384550 NS398 induces apoptosis in non-small cell lung cancer cells http://www.medworm.com/index.php?rid=5384552&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg36p4253x6468743%2F Conclusion  The current study proves that NS398 induces apoptosis in A549 cells, thereby inhibiting tumor growth. This function of NS398 may be related to the inhibition of AKT phosphorylation and survivin protein downregulation. Content Type Journal ArticleCategory Original PaperPages 1-6DOI 10.1007/s00432-011-1080-3Authors Rong Qiu, Zhejiang Medical College, Hangzhou, 310053 ChinaJian Chen, Zhejiang Medical College, Hangzhou, 310053 ChinaJun Sima, Red Cross Hospital in Hangzhou, Hangzhou, 310004 ChinaXiangdi Shen, Zhejiang Medical College, Hangzhou, 310053 ChinaDandan Liu, Zhejiang Medical College, Hangzhou, 310053 ChinaJian Shen, Zhejiang Medical College, Hangzhou, 310053 China Journal Journal of Cancer Research and Clinical OncologyOnline ISSN 1432-1335Prin... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5384552 Wed, 02 Nov 2011 16:55:56 +0100 5384552 The pattern of lymph node metastasis and the suitability of 7th UICC N stage in predicting prognosis of remnant gastric cancer http://www.medworm.com/index.php?rid=5384553&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ffgw7864575j85881%2F Conclusions  Preoperative diagnosis of depth of invasion and tumor size can help surgeons to evaluate LN metastasis. The 7th UICC N stage may be unsuitable and should be evaluated and improved in order to help surgeons rationally to estimate N stage of RGC. Content Type Journal ArticleCategory Original PaperPages 1-7DOI 10.1007/s00432-011-1034-9Authors Fangxuan Li, Department of Gastric Cancer Surgery, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, ChinaRupeng Zhang, Department of Gastric Cancer Surgery, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, ChinaHan Liang, Department of Gastric Cancer Surgery, Key Laboratory of Cancer Prev... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5384553 Wed, 02 Nov 2011 16:55:55 +0100 5384553 VEGF gene alternative splicing: pro- and anti-angiogenic isoforms in cancer http://www.medworm.com/index.php?rid=5384554&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx7tl74160755j132%2F Abstract  Tumor growth and progression depend on angiogenesis, a process of new blood vessels formation from a preexisting vascular endothelium. Tumors promote angiogenesis by secreting or activating angiogenic factors that stimulate endothelial proliferation and migration and capillary morphogenesis. The newly formed blood vessels provide nutrients and oxygen to the tumor, increasing its growth. Thus, angiogenesis plays a key role in cancer progression and development of metastases. An important growth factor that promotes angiogenesis and participates in a variety of physiological and pathological processes is the vascular endothelial growth factor (VEGF-A or VEGF). Overexpression of VEGF results in increased angiogenesis in normal and pathological conditions. The existen... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5384554 Tue, 01 Nov 2011 16:51:34 +0100 5384554 PTEN-mediated AKT activation contributes to the reduced apoptosis among Indian oral squamous cell carcinoma patients http://www.medworm.com/index.php?rid=5359959&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv1155478016x3w3m%2F Conclusion  The present study confirms the contribution of loss of PTEN expression in Akt phosphorylation and spontaneous apoptosis suppression in the specimens of oral cancer. Both PTEN and phospho-Akt are likely to be concerned with oral cancer progression and reduced incidence of spontaneous apoptosis Content Type Journal ArticleCategory Original PaperPages 1-7DOI 10.1007/s00432-011-1077-yAuthors Nisreen Sherif Alyasiri, Genome Biology Lab, Department of Biosciences, Jamia Millia Islamia, Maulana Mohammad Ali Jauhar Marg, New Delhi, 110025 IndiaSyed Jafar Mehdi, Genome Biology Lab, Department of Biosciences, Jamia Millia Islamia, Maulana Mohammad Ali Jauhar Marg, New Delhi, 110025 IndiaM. Shabbir Alam, Genome Biology Lab, Department of Biosciences, Jamia Millia Isla... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5359959 Fri, 28 Oct 2011 06:05:35 +0100 5359959 Condensed chromatin staining of CKAP2 as surrogate marker for mitotic figures http://www.medworm.com/index.php?rid=5346884&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F356v34n553557428%2F Conclusion  Immunohistochemical staining with CKAP2 monoclonal antibody can be considered to be a new, effective approach to the assessment of proliferation activity in cancer tissues. Content Type Journal ArticleCategory Original PaperPages 1-8DOI 10.1007/s00432-011-1053-6Authors Han-Seong Kim, Department of Pathology, Ilsan Paik Hospital, Inje University, Ilsanseo-gu, Goyang, 411-702 KoreaYong-Bock Choi, Research Institute, National Cancer Center, 111 Jungbalsan-ro, 323 Ilsan-ro, Ilsandong-gu, Goyang, 410-769 KoreaJung-Hwa Lee, Research Institute, National Cancer Center, 111 Jungbalsan-ro, 323 Ilsan-ro, Ilsandong-gu, Goyang, 410-769 KoreaSeong-Yeol Park, Research Institute, National Cancer Center, 111 Jungbalsan-ro, 323 Ilsan-ro, Ilsandong-gu, Goyang, 410-769 KoreaH... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5346884 Fri, 21 Oct 2011 16:01:17 +0100 5346884 A cluster of specified microRNAs in peripheral blood as biomarkers for metastatic non-small-cell lung cancer by stem-loop RT-PCR http://www.medworm.com/index.php?rid=5335133&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe247611634153031%2F Conclusion  Hsa-miR-126 and hsa-miR-183 may serve as potential serum biomarkers for metastatic non-small-cell lung cancer. Content Type Journal ArticleCategory Original PaperPages 1-9DOI 10.1007/s00432-011-1068-zAuthors Qingfeng Lin, Oncology Department, Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, Jiangsu, ChinaWeidong Mao, Oncology Department, Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, Jiangsu, ChinaYongqian Shu, Oncology Department, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, ChinaFeng Lin, Oncology Department, Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, Jiangsu, ChinaShaoping Liu, Oncology Department, Affiliated Jiangyin Hospi... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5335133 Wed, 19 Oct 2011 05:55:50 +0100 5335133 Dual action of a selective cyclooxygenase-2 inhibitor on vascular endothelial growth factor expression in human hepatocellular carcinoma cells: novel involvement of discoidin domain receptor 2 http://www.medworm.com/index.php?rid=5335134&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F656v08lu5p601467%2F Conclusion  These findings disclose a novel cell-dependent regulatory mechanism of VEGF involving DDR2 gene in HCC cells. Content Type Journal ArticleCategory Original PaperPages 1-12DOI 10.1007/s00432-011-1075-0Authors Nam Oak Lee, Liver and Pancreatobiliary Cancer Research Branch, National Cancer Center, Goyang, South KoreaJoong-Won Park, Liver and Pancreatobiliary Cancer Research Branch, National Cancer Center, Goyang, South KoreaJung Ahn Lee, Liver and Pancreatobiliary Cancer Research Branch, National Cancer Center, Goyang, South KoreaJu Hyun Shim, Center for Liver Cancer, National Cancer Center, 323 Ilsan-ro, Ilsan dong-gu, Goyang, Gyeonggi 411-769, South KoreaSun-Young Kong, Center for Clinical Services, National Cancer Center, Goyang, South KoreaKyung Tae Kim, Fun... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5335134 Tue, 18 Oct 2011 15:59:21 +0100 5335134 Addition of iron to erythropoiesis-stimulating agents in cancer patients: a meta-analysis of randomized trials http://www.medworm.com/index.php?rid=5296592&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq438020611541690%2F Conclusion  Overall parenteral iron reduces the risk of transfusions by 23% and increases the chance of hematopoietic response by 29% when compared with ESAs alone. On the contrary, oral iron does not increase hematopoietic response nor transfusion rate. The significance of these results is that the proportion of non-responders to ESAs will have strongly improved and quality of life and cost ameliorated. Content Type Journal ArticleCategory ReviewPages 1-9DOI 10.1007/s00432-011-1072-3Authors Fausto Petrelli, Oncology Unit, Azienda Ospedaliera Treviglio-Caravaggio, Piazzale Ospedale 1, 24047 Treviglio, BG, ItalyKaren Borgonovo, Oncology Unit, Azienda Ospedaliera Treviglio-Caravaggio, Piazzale Ospedale 1, 24047 Treviglio, BG, ItalyMary Cabiddu, Oncology Unit, Azienda ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5296592 Wed, 05 Oct 2011 05:49:19 +0100 5296592 First-line panitumumab plus irinotecan/5-fluorouracil/leucovorin treatment in patients with metastatic colorectal cancer http://www.medworm.com/index.php?rid=5285158&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh14l788533301621%2F Conclusions  As expected, consistently favourable efficacy was observed in patients with KRAS WT versus MT tumours receiving first-line panitumumab plus FOLFIRI treatment. Content Type Journal ArticleCategory Original PaperPages 1-8DOI 10.1007/s00432-011-1061-6Authors Claus-Henning Köhne, Department of Hematology and Oncology, Onkologie Klinikum Oldenburg, 26133 Oldenburg, GermanyRalf Hofheinz, Day Treatment Centre at the Interdisciplinary Tumour Centre Mannheim, Universitätsmedizin Mannheim, Mannheim, GermanyLaurent Mineur, Radiology and Oncology Centre, Institut Sainte-Catherine, Avignon, FranceHenry Letocha, Department of Oncology, County Hospital, Västerås, SwedenRichard Greil, Third Medical Department, University Hospital Salzburg, Salzburg, AustriaJosef Thale... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5285158 Fri, 30 Sep 2011 05:52:58 +0100 5285158 Analysis of the contribution of nasopharyngeal epithelial cancer cells to the induction of a local inflammatory response http://www.medworm.com/index.php?rid=5285159&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg7510812m7k49307%2F Conclusions  Nasopharyngeal epithelial cancer cells may play a significant role in maintaining and amplifying the inflammation process via activation of NF-κB and STAT3 pathway and through the local production of pro-inflammatory cytokines, which recruit and activate additional immune cells in the nasopharyngeal path and promote tumour progression. Content Type Journal ArticleCategory Original PaperPages 1-8DOI 10.1007/s00432-011-1066-1Authors Qianjin Liao, Cancer Research Institute, Central South University, 110 Xiang-Ya Road, Changsha, 410078 Hunan, People’s Republic of ChinaXiaofang Guo, Cancer Research Institute, Central South University, 110 Xiang-Ya Road, Changsha, 410078 Hunan, People’s Republic of ChinaXiaoling Li, Cancer Research Institute, Central Sout... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5285159 Fri, 30 Sep 2011 05:52:57 +0100 5285159 Meeting report of the third Heidelberg myeloma workshop: current status and developments in diagnosis and therapy of multiple myeloma http://www.medworm.com/index.php?rid=5285160&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ffv121612r4u55431%2F Content Type Journal ArticleCategory Meeting ReportPages 1-6DOI 10.1007/s00432-011-1071-4Authors Jens Hillengaß, Department of Hematology and Oncology, University of Heidelberg, Heidelberg, GermanyKai Neben, Department of Hematology and Oncology, University of Heidelberg, Heidelberg, GermanyHartmut Goldschmidt, Department of Hematology and Oncology, University of Heidelberg, Heidelberg, Germany Journal Journal of Cancer Research and Clinical OncologyOnline ISSN 1432-1335Print ISSN 0171-5216 (Source: Journal of Cancer Research and Clinical Oncology) Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5285160 Fri, 30 Sep 2011 05:52:55 +0100 5285160 The microRNA-processing enzymes: Drosha and Dicer can predict prognosis of nasopharyngeal carcinoma http://www.medworm.com/index.php?rid=5273226&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1645w0l0v512w376%2F Conclusions  We observed that Drosha and Dicer expression was dysregulation in NPC compared with healthy control samples and was significantly correlated with shorter PFS and OS of NPC patients. Therefore, we hypothesise that the expression levels of Dicer and Drosha could be used as potential prognostic biomarkers for NPC. Content Type Journal ArticleCategory Original PaperPages 1-8DOI 10.1007/s00432-011-1058-1Authors Xiaofang Guo, Cancer Research Institute, Central South University, 110 Xiang-Ya Road, Changsha, 410078 Hunan, People’s Republic of ChinaQianjin Liao, Cancer Research Institute, Central South University, 110 Xiang-Ya Road, Changsha, 410078 Hunan, People’s Republic of ChinaPan Chen, Cancer Research Institute, Central South University, 110 Xiang-Ya Ro... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5273226 Wed, 28 Sep 2011 05:51:08 +0100 5273226 Quantitative methylation analysis of HOXA3, 7, 9, and 10 genes in glioma: association with tumor WHO grade and clinical outcome http://www.medworm.com/index.php?rid=5273227&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F70674226xx681634%2F Conclusions  This study identifies HOXA3, 7, 9, and 10 as methylation targets mainly in high-grade glioma and hypermethylation of the HOXA9 and 10 as prognostic factor in glioblastoma patients. Our data indicate that these epigenetic changes may be biomarkers of clinically different subgroups of glioma patients that could eventually benefit from personalized therapeutic strategies. Content Type Journal ArticleCategory Original PaperPages 1-13DOI 10.1007/s00432-011-1070-5Authors Angela Di Vinci, Laboratory of Tumor Genetics and Epigenetics, Istituto Nazionale per la Ricerca sul Cancro, IST Largo Rosanna Benzi 10, 16132 Genoa, ItalyIda Casciano, Laboratory of Tumor Genetics and Epigenetics, Istituto Nazionale per la Ricerca sul Cancro, IST Largo Rosanna Benzi 10, 16132 ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5273227 Tue, 27 Sep 2011 05:46:23 +0100 5273227 Adjuvant immunotherapy of C6 glioma in rats with pertussis toxin http://www.medworm.com/index.php?rid=5273228&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn65x7368kt511318%2F Conclusion  These results suggest that PTx could be an immunotherapeutic adjuvant in the integral therapy against glial tumors. Content Type Journal ArticleCategory Original PaperPages 1-11DOI 10.1007/s00432-011-1069-yAuthors Mario Orozco-Morales, Neuroimmunology Unit, Instituto Nacional de Neurologia y Neurocirugia (INNN), Insurgentes Sur 3877, 14269 Mexico City, MexicoFrancisco-Javier Sánchez-García, Immunoregulation Unit from Instituto Politecnico Nacional, Mexico City, MexicoPatricia Guevara-Salazar, Neuroimmunology Unit, Instituto Nacional de Neurologia y Neurocirugia (INNN), Insurgentes Sur 3877, 14269 Mexico City, MexicoOscar Arrieta, Laboratory of Experimental Oncology, Instituto Nacional de Cancerologia (INCan), Mexico City, MexicoNorma Y. Hernández-Pedro, La... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5273228 Tue, 27 Sep 2011 05:46:22 +0100 5273228 Calcium-binding protein S100P and cancer: mechanisms and clinical relevance http://www.medworm.com/index.php?rid=5260139&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5280108m18510q07%2F Abstract  S100P is a 95-amino-acid protein and a member of the S100 family. It was first purified from placenta. The promoter area of S100P has binding sites for SMAD, STAT/CREB and SP/KLF, key regulatory elements participating in transcriptional activation of the S100P gene. Increased levels of S100P have been observed in multiple tumor cell lines and breast, pancreas, lung and ovary carcinomas. S100P has been shown to mediate tumor growth, metastasis and invasion through the binding of Ca2+ ions, receptor for advanced glycation end products, cytoskeletal protein ezrin, calcyclin-binding protein/Siah-1-interacting protein and cathepsin D. S100P could potentially serve as diagnostic marker, prognostic/predictive indicator and therapy target for different carcinomas. Con... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5260139 Sat, 24 Sep 2011 05:43:05 +0100 5260139 Receptor for advanced glycation end products (RAGE) partially mediates HMGB1-ERKs activation in clear cell renal cell carcinoma http://www.medworm.com/index.php?rid=5260138&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd13q0136674t6640%2F Conclusion  HMGB1 promotes the development and progression of CCRCC via ERK1/2 activation, which is partially mediated by RAGE. Content Type Journal ArticleCategory Original PaperPages 1-12DOI 10.1007/s00432-011-1067-0Authors Liguo Lin, Department of Urinary Surgery, MeiZhou People’s Hospital, Meizhou Affiliated Hospital of Sun Yat-sen University, Huangtang Road, Meijiang District, Meizhou, Guangdong Province 514031, People’s Republic of ChinaKaihua Zhong, Department of Urinary Surgery, MeiZhou People’s Hospital, Meizhou Affiliated Hospital of Sun Yat-sen University, Huangtang Road, Meijiang District, Meizhou, Guangdong Province 514031, People’s Republic of ChinaZhongkai Sun, Department of Urinary Surgery, MeiZhou People’s Hospital, Meizhou Affiliated Hospital ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5260138 Sat, 24 Sep 2011 05:43:05 +0100 5260138 Safety study of axillary reverse mapping in the surgical treatment for breast cancer patients http://www.medworm.com/index.php?rid=5260140&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ffwk67161w7672170%2F Conclusion  Crossover between breast and ipsilateral arm lymphatic drainage system contributes for ipsilateral arm lymph node metastasis. When ARM and SLNB are simultaneously performed in a patient, selectively preservation of the ARM nodes that do not coincided with SLNs would be safe, even if the SLNs are positive. Pathological lymph node status does not account for the occurrence of metastasis in ARM nodes. ARM nodes could be preserved safely, independent of the pathological lymph node status. Content Type Journal ArticleCategory Original PaperPages 1-6DOI 10.1007/s00432-011-1064-3Authors Heran Deng, Department of Breast Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiangxi Road, Guangzhou, 510120 People’s Republic of ChinaLun Chen, Dep... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5260140 Tue, 20 Sep 2011 15:46:37 +0100 5260140 BCG response prediction with cytokine gene variants and bladder cancer: where we are? http://www.medworm.com/index.php?rid=5260141&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6p607345005x5146%2F Conclusion  Research continues to establish the most effectual strain of BCG and the best dosage schedule for the treatment for bladder cancer but, on the other hand, a very critical part of this therapy to find out the correlation of different cytokine with BCG therapy, which will give a better insights not only the mechanism but also a better therapeutic options. Content Type Journal ArticleCategory ReviewPages 1-10DOI 10.1007/s00432-011-1056-3Authors Dinesh Kumar Ahirwar, Andrology and IVF Laboratories, University of Utah, Salt lake city, UT 84108, USAParmeet Kaur Manchanda, Division of Endocrinology, James Cancer Center, The Ohio State University, Columbus, OH 43210, USARama Devi Mittal, Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5260141 Tue, 20 Sep 2011 05:51:07 +0100 5260141 Molecular analysis of oncogenicity of the transcription factor, BRN3A, in cervical cancer cells http://www.medworm.com/index.php?rid=5250274&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl7328r73u0r28525%2F Conclusions  BRN3A possesses anti-apoptotic property, and considering the above results, it may be regarded as the key component in promoting tumorigenic growth in the uterine cervical cells. Content Type Journal ArticleCategory Original PaperPages 1-9DOI 10.1007/s00432-011-1059-0Authors Biswa Pratim Das Purkayastha, Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, 221005 IndiaJagat Kumar Roy, Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, 221005 India Journal Journal of Cancer Research and Clinical OncologyOnline ISSN 1432-1335Print ISSN 0171-5216 (Source: Journal of Cancer Research and Clinical Oncology) Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5250274 Sun, 18 Sep 2011 05:51:29 +0100 5250274 Endothelial progenitor cells are associated with response to chemotherapy in human non-small-cell lung cancer http://www.medworm.com/index.php?rid=5236787&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn8u53036221517k7%2F Conclusion  Peripheral blood levels of bone marrow-derived EPCs are significantly increased in patients with NSCLC and correlate with response to chemotherapy. EPCs may offer a possible biomarker for efficient of treatment and prognosis. Content Type Journal ArticleCategory Original PaperPages 1-9DOI 10.1007/s00432-011-1043-8Authors Ryo Morita, Department of Cardiovascular and Respiratory Medicine, Akita University Graduate School of Medicine, Hondo 1-1-1, Akita, 010-8543 JapanKazuhiro Sato, Department of Cardiovascular and Respiratory Medicine, Akita University Graduate School of Medicine, Hondo 1-1-1, Akita, 010-8543 JapanMariko Nakano, Department of Cardiovascular and Respiratory Medicine, Akita University Graduate School of Medicine, Hondo 1-1-1, Akita, 010-8543 J... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5236787 Sat, 17 Sep 2011 05:49:08 +0100 5236787 Expression and clinical significance of leptin, the functional receptor of leptin (OB-Rb) and HER-2 in non-small-cell lung cancer: a retrospective analysis http://www.medworm.com/index.php?rid=5236788&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F37w2288707jv7u23%2F Conclusions  The expression of leptin, OB-Rb and HER-2 was significantly higher in NSCLC tissues than in normal lung tissues. The expression of leptin is an independent prognostic factor for NSCLC. Content Type Journal ArticleCategory Original PaperPages 1-8DOI 10.1007/s00432-011-1054-5Authors Yan-Jie Xu, Department of Medical Oncology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029 Jiangsu Province, People’s Republic of ChinaYong-Feng Shao, Department of Thoracic and Cardiac Surgery, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029 Jiangsu Province, People’s Republic of ChinaXia Zhao, Department of Pneumology, Nanjing Chest Hospital, 215 Guangzhou Road, Nanjing, 2100... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5236788 Fri, 16 Sep 2011 16:44:22 +0100 5236788 Identification of GLIPR1 tumor suppressor as methylation-silenced gene in acute myeloid leukemia by microarray analysis http://www.medworm.com/index.php?rid=5236789&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj2323m7n23muwp82%2F Conclusion  We identify 109 genes induced by demethylation in HL-60 cells, and demonstrate that GLIPR1 is a methylation-silenced gene in the AML patients, and may serve as a marker for monitoring disease activity during therapy in the AML patients. The data provide the important information for studying the pathogenesis of AML and discovering the target genes of methylating agents. Content Type Journal ArticleCategory Original PaperPages 1-10DOI 10.1007/s00432-011-1065-2Authors Yan-Hua Xiao, Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, 410008 Hunan, ChinaXin-Hui Li, Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, 410008 ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5236789 Fri, 16 Sep 2011 05:46:30 +0100 5236789 RUNX3 expression is lost in glioma and its restoration causes drastic suppression of tumor invasion and migration http://www.medworm.com/index.php?rid=5236790&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2757x12567r1lvg7%2F Conclusions  Our data indicated that RUNX3 expression is significantly decreased in human glioma, and targeting of the RUNX3 pathway may constitute a potential treatment modality for glioma. Content Type Journal ArticleCategory Original PaperPages 1-8DOI 10.1007/s00432-011-1063-4Authors Peng-Jin Mei, Department of Neurosurgery, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006 Jiangsu Province, ChinaJin Bai, Jiangsu Key Laboratory of Biological Cancer Therapy, Xuzhou Medical College, 84 West Huaihai Road, Xuzhou, 221002 Jiangsu Province, ChinaHui Liu, School of Pathology, Xuzhou Medical College, Xuzhou, 221002 ChinaChen Li, The First Affiliated Hospital of Xuzhou Medical College, Xuzhou, 221002 ChinaYong-Ping Wu, School of Pathology... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5236790 Fri, 16 Sep 2011 05:46:29 +0100 5236790 The combined treatment of CT-guided percutaneous 125I seed implantation and chemotherapy for non-small-cell lung cancer http://www.medworm.com/index.php?rid=5236791&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh73q4542131155r2%2F Conclusions  Our initial experience showed that combined CT-guided 125I radioactive seed implantation and GP chemotherapy are effective and safe for treating advanced NCSLC. Content Type Journal ArticleCategory Original PaperPages 1-10DOI 10.1007/s00432-011-1048-3Authors Shengchu Zhang, Department of General Surgery, The First Affiliated Hospital, Wenzhou Medical College, Wenzhou, 325000 ChinaYihu Zheng, Department of General Surgery, The First Affiliated Hospital, Wenzhou Medical College, Wenzhou, 325000 ChinaPanpan Yu, Department of General Surgery, The First Affiliated Hospital, Wenzhou Medical College, Wenzhou, 325000 ChinaFuxiang Yu, Department of General Surgery, The First Affiliated Hospital, Wenzhou Medical College, Wenzhou, 325000 ChinaQiyu Zhang, Department o... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5236791 Fri, 16 Sep 2011 05:46:28 +0100 5236791 Prognostic significance of vascular endothelial growth factor expression in gastric carcinoma: a meta-analysis http://www.medworm.com/index.php?rid=5236792&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F633331446178h261%2F Conclusion  Our results indicate that VEGF can potently predict the overall survival in Asian patients with gastric cancer. Importantly, VEGF may be converted from candidate to the routine clinical setting for clinicians to predict the outcome of single patient with gastric carcinoma. Content Type Journal ArticleCategory Original PaperPages 1-14DOI 10.1007/s00432-011-1057-2Authors Jing Chen, The Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai, 200241 ChinaTao Li, The Affiliated Hospital of Ningxia Medical University, Yinchuan, 750004 ChinaYuanyuan Wu, The Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai, 200241 ChinaLijun He... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5236792 Thu, 15 Sep 2011 05:53:50 +0100 5236792 Docetaxel-based therapy with or without estramustine as first-line chemotherapy for castration-resistant prostate cancer: a meta-analysis of four randomized controlled trials http://www.medworm.com/index.php?rid=5224733&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff474r231078232k8%2F Conclusions  This was the first meta-analysis of docetaxel-based therapy with estramustine versus docetaxel-based chemotherapy in the treatment of castration-resistant prostate cancer. Our meta-analysis did not support the addition of estramustine to docetaxel-based chemotherapy for the treatment of castration- resistant prostate cancer, based on no gain in survival. Content Type Journal ArticleCategory Original PaperPages 1-6DOI 10.1007/s00432-011-1052-7Authors Wei-Xiang Qi, Department of Oncology, The Sixth People Hospital, Shanghai Jiao Tong University, Shanghai, 200233 ChinaZan Shen, Department of Oncology, The Sixth People Hospital, Shanghai Jiao Tong University, Shanghai, 200233 ChinaYang Yao, Department of Oncology, The Sixth People Hospital, Shanghai Jiao Ton... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5224733 Wed, 14 Sep 2011 05:43:51 +0100 5224733 A clinicopathological model to predict bone metastasis in hepatocellular carcinoma http://www.medworm.com/index.php?rid=5224732&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp51016k861v37315%2F Conclusion  The simple prediction model constructed from clinicopathological parameters is accurate in predicting BM development in HCC patients. Content Type Journal ArticleCategory Original PaperPages 1-7DOI 10.1007/s00432-011-1060-7Authors Zuo-Lin Xiang, Department of Radiation Oncology, Zhongshan Hospital, Fudan University, 136 Yi Xue Yuan Road, Shanghai, 200032 ChinaZhao-Chong Zeng, Department of Radiation Oncology, Zhongshan Hospital, Fudan University, 136 Yi Xue Yuan Road, Shanghai, 200032 ChinaJia Fan, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032 ChinaWei-Zhong Wu, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032 ChinaJian He, Department of Radiation Oncology, Zhongshan Hospital, Fudan University,... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5224732 Wed, 14 Sep 2011 05:43:51 +0100 5224732 Postoperative serum proteomic profiles may predict recurrence-free survival in high-risk primary breast cancer http://www.medworm.com/index.php?rid=5224734&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fmhh5nwj1r372274w%2F Conclusion  Investigation of the postoperative serum proteome by, e.g., anion-exchange fractionation followed by SELDI-TOF MS analysis is promising for the detection of novel prognostic factors. However, regarding the rather limited study population, validation of these results by analysis of independent study populations is warranted to assess the true clinical applicability of discovered prognostic markers. In addition, structural identification of the other markers will aid in elucidation of their role in breast cancer prognosis, as well as enable development of absolute quantitative assays. Content Type Journal ArticleCategory Original PaperPages 1-11DOI 10.1007/s00432-011-1055-4Authors Marie-Christine W. Gast, Department of Pharmacy and Pharmacology, The Nethe... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5224734 Tue, 13 Sep 2011 05:56:40 +0100 5224734 Interventional therapies of unresectable liver metastases http://www.medworm.com/index.php?rid=5224735&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6640714658117324%2F Abstract  Liver metastases are the major cause of mortality in patients with gastrointestinal carcinomas and other malignant tumors, carrying a poor prognosis and presenting considerable management. Surgical resection remains the only curative therapy for liver metastases up to now. However, only a small percentage of patients are suitable for curative resection due to many factors: multi-centric tumors, extrahepatic metastases, early vascular invasion, and coexisting advanced liver cirrhosis. In non-surgical cases, regional interventional therapies have led to a major break through in the treatment of unresectable liver metastases, which include transarterial chemoembolization (TACE), radiofrequency ablation (RFA), laser-induced thermotherapy (LITT), cryosurgical ablation ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5224735 Sat, 10 Sep 2011 15:48:19 +0100 5224735 Solute carrier protein family may involve in radiation-induced radioresistance of non-small cell lung cancer http://www.medworm.com/index.php?rid=5207886&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F208141587712x27j%2F Conclusions  The differentially expressed genes in both cell lines may contribute to their radioresistant phenotype. This extensive list of genes identified in the experiment provides a large body of potentially valuable information for studying the molecular mechanism(s) of radiosensitivity and identification of candidate molecular markers of radiation sensitivity. Thus, to our knowledge, the SLC gene superfamily is the first being reported to involve in acquired radioresistance. Content Type Journal ArticleCategory Original PaperPages 1-9DOI 10.1007/s00432-011-1050-9Authors Li Xie, Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, 440 Ji-Yan Road, Jinan, 250117 Shandong Province, ChinaXianrang Song, Shandong Provinci... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5207886 Fri, 09 Sep 2011 16:46:22 +0100 5207886 The relationship among PDX1, CDX2, and mucin profiles in gastric carcinomas; correlations with clinicopathologic parameters http://www.medworm.com/index.php?rid=5207885&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj086rx72k52g5h87%2F Conclusions  PDX1 expression revealed a higher positivity in gastric carcinomas than the previous studies and showed no relation with tumor type, clinicopathologic parameters, CDX2 expression, or mucin profiles. However, a significant relation of PDX1 and CDX2 expressions among phenotypic classification of gastric carcinomas reveals an idea about similar functions for PDX1 and CDX2 in the evolution of gastric carcinoma. Content Type Journal ArticleCategory Original PaperPages 1-14DOI 10.1007/s00432-011-1044-7Authors Fulya Oz Puyan, Department of Pathology, Trakya University Medical Faculty, Edirne, TurkeyNuray Can, Department of Pathology, Sanliurfa Education and Research Hospital, Sanliurfa, TurkeyFiliz Ozyilmaz, Department of Pathology, Trakya University Medical F... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5207885 Fri, 09 Sep 2011 16:46:22 +0100 5207885 OLFM4 is associated with lymph node metastasis and poor prognosis in patients with gastric cancer http://www.medworm.com/index.php?rid=5207888&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw7r137mgj2511p35%2F Conclusion  Gene expression profiles were useful for simultaneously analyzing the expression levels of thousands of genes. Reduced expression of OLFM4 in gastric cancer is associated significantly with lymph node and distant metastases and with poor prognosis. OLFM4 may prove to be an important molecular marker for predicting the carcinogenesis, development, progression, and metastasis of gastric cancer. Content Type Journal ArticleCategory Original PaperPages 1-8DOI 10.1007/s00432-011-1042-9Authors Zuyan Luo, Department of Radiology, Zhejiang Provincial People’s Hospital, Hangzhou, 310014 Zhejiang Province, ChinaQi Zhang, Department of Surgery, Zhejiang Provincial People’s Hospital, Hangzhou, 310014 Zhejiang Province, ChinaZhongsheng Zhao, Department of Patholo... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5207888 Fri, 09 Sep 2011 06:05:33 +0100 5207888 Etoposide-mediated glioblastoma cell death: dependent or independent on the expression of its target, topoisomerase II alpha? http://www.medworm.com/index.php?rid=5207887&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6x82200w78296727%2F Conclusions  In vitro, the levels of TopoIIa protein expression correlate with response to etoposide but also multiple molecular events namely DNA-PK and MDR also play a role in cell sensitivity to etoposide. That we did not find a high expression of TopoIIa in clinical specimens further suggests the mechanisms underlying treatment response are complex. Content Type Journal ArticleCategory Original PaperPages 1-8DOI 10.1007/s00432-011-1046-5Authors H. Sevim, Cure for Life Foundation Neuro-oncology Laboratory, Adult Cancer Program, Lowy Cancer Research Centre, Prince of Wales Clinical School, University of NSW, Sydney, NSW, AustraliaJ. F. Parkinson, Kolling Institute of Medical Research, University of Sydney, Sydney, NSW, AustraliaK. L. McDonald, Cure for Life Foundat... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5207887 Fri, 09 Sep 2011 06:05:33 +0100 5207887 PI3K/Akt and MAPK/ERK1/2 signaling pathways are involved in IGF-1-induced VEGF-C upregulation in breast cancer http://www.medworm.com/index.php?rid=5207889&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm2xv2q0g8010r115%2F Conclusion  This study identified that PI3K/Akt and MAPK/ERK1/2 signaling pathways were involved in IGF-1-induced VEGF-C up-regulation and suggested their important roles in lymphatic metastasis in breast cancer. Content Type Journal ArticleCategory ReviewPages 1-8DOI 10.1007/s00432-011-1049-2Authors Chenfang Zhu, Department of General Surgery, Shanghai Ninth People’s Hospital, Affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai, ChinaXiaoliang Qi, Department of General Surgery, Shanghai Ninth People’s Hospital, Affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai, ChinaYaning Chen, Department of General Surgery, Shanghai Ninth People’s Hospital, Affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai, Ch... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5207889 Fri, 09 Sep 2011 06:05:32 +0100 5207889 Gastrokine 1 functions as a tumor suppressor by inhibition of epithelial–mesenchymal transition in gastric cancers http://www.medworm.com/index.php?rid=5207890&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd6388k0m28q572h1%2F Conclusions  These data suggest that the GKN1 gene may play an important role in the progression of sporadic gastric cancers via inhibition of EMT and cancer cell migration. Content Type Journal ArticleCategory Original PaperPages 1-8DOI 10.1007/s00432-011-1051-8Authors Jung Hwan Yoon, Department of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, 137-701 South KoreaYoung Hwi Kang, Department of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, 137-701 South KoreaYoo Jin Choi, Department of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, 137-701 South KoreaIn Soo Park, Department of General Surgery, College of Medicine... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5207890 Tue, 06 Sep 2011 15:48:07 +0100 5207890 BMP9 inhibits the proliferation and invasiveness of breast cancer cells MDA-MB-231 http://www.medworm.com/index.php?rid=5207891&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx58670t280u1v382%2F Conclusions  Decreased BMP9 expression is associated with the elevated proliferation and migration of human breast cancer. BMP9 can inhibit the growth, invasion, and migration of breast cancer cells in vitro and in vivo. BMP9 is a putative tumor suppressor in breast cancer. Content Type Journal ArticleCategory Original PaperPages 1-10DOI 10.1007/s00432-011-1047-4Authors Ke Wang, Key Laboratory of Diagnostic Medicine Designated by the Chinese Ministry of Education, Chongqing Medical University, 1 YiXueYuan Road, Yuzhong District, Chongqing, 400016 ChinaHonglei Feng, Key Laboratory of Diagnostic Medicine Designated by the Chinese Ministry of Education, Chongqing Medical University, 1 YiXueYuan Road, Yuzhong District, Chongqing, 400016 ChinaWei Ren, The First Affiliated... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5207891 Sun, 04 Sep 2011 10:55:13 +0100 5207891 Identification of CD44+CD24+ gastric cancer stem cells http://www.medworm.com/index.php?rid=5196097&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Frn5718j58089t427%2F Conclusions  These studies strongly suggest that the CD44+CD24+ subpopulation of human gastric cancer cell lines, AGS, is gastric cancer stem cells. Content Type Journal ArticleCategory Original PaperPages 1-8DOI 10.1007/s00432-011-1038-5Authors Chaojun Zhang, Department of General Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037 ChinaChenwei Li, Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI 48109, USAFengtian He, Department of Biochemistry and Molecular Biology, Third Military Medical University, Chongqing, 400038 ChinaYujiao Cai, Department of General Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037 ChinaHua Yang, Department of General Surgery, Xinqiao Hospital, Third Militar... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5196097 Thu, 01 Sep 2011 06:11:32 +0100 5196097 The CDK inhibitors in cancer research and therapy http://www.medworm.com/index.php?rid=5183329&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3038238j26510844%2F Abstract  Chemical compounds that interfere with an enzymatic function of kinases are useful for gaining insight into the complicated biochemical processes in mammalian cells. Cyclin-dependent kinases (CDK) play an essential role in the control of the cell cycle and/or proliferation. These kinases as well as their regulators are frequently deregulated in different human tumors. Aberrations in CDK activity have also been observed in viral infections, Alzheimer’s, Parkinson’s diseases, ischemia and some proliferative disorders. This led to an intensive search for small-molecule CDK inhibitors not only for research purposes, but also for therapeutic applications. Here, we discuss seventeen CDK inhibitors and their use in cancer research or therapy. This review should help ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5183329 Tue, 30 Aug 2011 05:43:13 +0100 5183329 Redox regulation of cytokeratin 18 protein by NADPH oxidase 1 in preneoplastic human epithelial cells http://www.medworm.com/index.php?rid=5183330&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj0u326320845735p%2F Conclusion  We demonstrated that Nox1 was able to induce CK18 stabilization by inhibiting CK18 protein degradation in a phosphorylation-dependent manner. CK18 accumulation induced by Nox1 is consistent with the persistence of fetal-type CK18 protein in many epithelial carcinomas. Content Type Journal ArticleCategory Original PaperPages 1-10DOI 10.1007/s00432-011-1041-xAuthors Apsorn Sattayakhom, Department of Internal Medicine IV (Gastroenterology and Infectious Disease), University Heidelberg Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, GermanyWanida Ittiwat, Faculty of Medical Technology, Mahidol University, Bangkok, ThailandWolfgang Stremmel, Department of Internal Medicine IV (Gastroenterology and Infectious Disease), University Heidelberg Hospital, Im Ne... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5183330 Tue, 30 Aug 2011 05:43:12 +0100 5183330 Possible association of NAT2 polymorphism with laryngeal cancer risk: an evidence-based meta-analysis http://www.medworm.com/index.php?rid=5183331&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq406278531wj654x%2F Conclusions  This meta-analysis suggested that there was overall lack of association between NAT2 polymorphism and laryngeal cancer risk; however, NAT2 slow acetylation may contribute to a risk factor for laryngeal cancer in Asians but not in Caucasians. Content Type Journal ArticleCategory Original PaperPages 1-7DOI 10.1007/s00432-011-1045-6Authors Xin-Jiang Ying, Department of Otolaryngology-Head and Neck Surgery, Shanghai First People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200080 ChinaPin Dong, Department of Otolaryngology-Head and Neck Surgery, Shanghai First People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200080 ChinaBin Shen, Department of Otolaryngology-Head and Neck Surgery, Shanghai First P... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5183331 Mon, 29 Aug 2011 16:00:03 +0100 5183331 Characteristics of aggressive variants in T1a renal cell carcinoma http://www.medworm.com/index.php?rid=5175464&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe7768727m5576x67%2F Conclusion  RCC patients with findings at diagnosis of a symptomatic cancer, a sarcomatoid component and CRP level of 0.4 mg/dL or more require intensive follow-up. Content Type Journal ArticleCategory Original PaperPages 1-7DOI 10.1007/s00432-011-1040-yAuthors Tatsuya Takayama, Department of Urology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka 431-3192, JapanTakayuki Sugiyama, Department of Urology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka 431-3192, JapanFumitake Kai, Department of Urology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka 431-3192, JapanTakahisa Suzuki, Department of Urology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu,... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5175464 Sat, 27 Aug 2011 15:47:33 +0100 5175464 BIRC5 promoter SNPs do not affect nuclear survivin expression and survival of malignant pleural mesothelioma patients http://www.medworm.com/index.php?rid=5161002&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp0131ur53751x265%2F Conclusion  Our findings indicate no relationship between BIRC5 genotypes and survivin expression or overall survival in mesothelioma patients. We observed that BIRC5 −241C > T polymorphism had a significant effect on patient age at diagnosis. Content Type Journal ArticleCategory Original PaperPages 1-11DOI 10.1007/s00432-011-1030-0Authors Julija Hmeljak, College of Health Care Izola, University of Primorska, Polje 42, 6310 Izola, SloveniaNina Erčulj, Faculty of Medicine, Institute of Biochemistry, Pharmacogenetics Laboratory, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, SloveniaVita Dolžan, Faculty of Medicine, Institute of Biochemistry, Pharmacogenetics Laboratory, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, SloveniaIzidor Kern, ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5161002 Mon, 22 Aug 2011 16:00:23 +0100 5161002 Down-regulation of JAK1 by RNA interference inhibits growth of the lung cancer cell line A549 and interferes with the PI3K/mTOR pathway http://www.medworm.com/index.php?rid=5161003&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn07415k61282x884%2F Conclusion  Our study suggests that JAK1 expression and phosphorylation is abnormal in NSCLC tissues. The knockdown of JAK1 significantly inhibits tumourigenicity of the A549 cell line and demonstrates that crosstalk between the JAK1 and PI3K/mTOR pathways is involved. Content Type Journal ArticleCategory Original PaperPages 1-12DOI 10.1007/s00432-011-1037-6Authors Dan Liu, Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, 610041 People’s Republic of ChinaYi Huang, Clinical Laboratory Department, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu, ChinaJing Zeng, Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, 610041 People’s Republic of ChinaBojiang Che... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5161003 Mon, 22 Aug 2011 16:00:21 +0100 5161003 Influence of the vascular damaging agents DMXAA and ZD6126 on hypericin distribution and accumulation in RIF-1 tumors http://www.medworm.com/index.php?rid=5161004&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe216244n54334141%2F Conclusions  We conclude that HYP accumulation is optimal when it is administered after VDA injection. We also found that HYP accumulation in necrosis is not changed when using VDAs with different working mechanisms. This insight provides a rationale for tumor necrosis therapy (TNT) using iodine-131-labeled hypericin ([131I]-HYP) in combination with VDAs. Content Type Journal ArticleCategory Original PaperPages 1-9DOI 10.1007/s00432-011-1032-yAuthors Thierry Marysael, Laboratorium voor Farmaceutische Biologie, Faculteit Farmaceutische Wetenschappen, K. U. Leuven, Herestraat 49-Bus 824, 3000 Leuven, BelgiumYicheng Ni, Departement Radiology, Faculteit Geneeskunde, K. U. Leuven, Leuven, BelgiumEvelyne Lerut, Departement Medisch Diagnostische Wetenschappen, Faculteit Gen... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5161004 Sat, 20 Aug 2011 15:52:21 +0100 5161004 Overexpression of osteopontin and integrin αv in laryngeal and hypopharyngeal carcinomas associated with differentiation and metastasis http://www.medworm.com/index.php?rid=5161005&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F53w8407qq0214197%2F Conclusions  The expression of OPN and ITGAV was significantly influenced to the differentiation and metastasis of the LHSCC. Overexpression of the OPN and ITGAV may have contributed to invasion and metastasis of the LHSCC, and therefore, OPN and ITGAV may have value as a target for chemotherapy in LHSCC treatment. Content Type Journal ArticleCategory Original PaperPages 1-6DOI 10.1007/s00432-011-1024-yAuthors Jian Guang Lu, Department of Otolaryngology/Head and Neck Surgery, Second Affiliated Hospital of Harbin Medical University, No. 246, Xue Fu Road, Harbin City, 150081 People’s Republic of ChinaYong Li, Department of Otolaryngology/Head and Neck Surgery, Second Affiliated Hospital of Harbin Medical University, No. 246, Xue Fu Road, Harbin City, 150081 People’... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5161005 Fri, 19 Aug 2011 06:40:44 +0100 5161005 Genome-wide identification of possible methylation markers chemosensitive to targeted regimens in colorectal cancers http://www.medworm.com/index.php?rid=5161007&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx442332q7h81k238%2F Conclusions  Two novel genes, GALR2 and ALX4, have been identified as chemosensitive methylation candidates to bevacizumab and cetuximab regimens, respectively. As our study did not include a clinical association study, the two candidates should be validated in large clinical cohorts, hopefully predicting responsive patients to targeted regimens. Content Type Journal ArticleCategory Original PaperPages 1-10DOI 10.1007/s00432-011-1036-7Authors Jin C. Kim, Department of Surgery, University of Ulsan College of Medicine, Seoul, KoreaHan C. Lee, Institute of Innovative Cancer Research and Asan Institute for Life Sciences, Asan Medical Center, 86 Asanbyeongwon-gil, Sonpa-gu, Seoul, KoreaDong H. Cho, Institute of Innovative Cancer Research and Asan Institute for Life Scienc... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5161007 Thu, 18 Aug 2011 05:59:43 +0100 5161007 Microelectromechanical system-based diagnostic technology for cervical cancer http://www.medworm.com/index.php?rid=5161006&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff05q037778q22274%2F Conclusions  MEMS is a sensitive and accurate method for capturing and enriching cells of interest. This technique is potentially useful in detecting cervical cancer at all stages, as well as other cancers with similar characteristics of cell surface antigen expression. Content Type Journal ArticleCategory Rapid CommunicationPages 1-7DOI 10.1007/s00432-011-1019-8Authors Song Gao, Department of Obstetric and Gynecology, Shengjing Hospital of the China Medical University Shenyang, Shenyang, 110004 ChinaXinyan Wang, Department of Obstetric and Gynecology, Shengjing Hospital of the China Medical University Shenyang, Shenyang, 110004 China Journal Journal of Cancer Research and Clinical OncologyOnline ISSN 1432-1335Print ISSN 0171-5216 (Source: Journal of Cancer Re... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5161006 Thu, 18 Aug 2011 05:59:43 +0100 5161006 Diagnosis value of focal liver lesions with SonoVue®-enhanced ultrasound compared with contrast-enhanced computed tomography and contrast-enhanced MRI: a meta-analysis http://www.medworm.com/index.php?rid=5161008&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F61741u56784h3p24%2F Conclusions  In comparison, SonoVue®-enhanced ultrasound had high pooled sensitivity and pooled specificity. SROC analysis showed the diagnostic value of FLLs with SonoVue®-enhanced ultrasound has no significant difference compared with CECT and CEMRI. SonoVue®-enhanced ultrasound is highly sensitive and specific in the characterization of FLLs to support an effective diagnostic method. Content Type Journal ArticleCategory Original PaperPages 1-11DOI 10.1007/s00432-011-1035-8Authors Yang Guang, Department of Ultrasound, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang, 110004 Liaoning, ChinaLiMei Xie, Department of Ultrasound, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang, 110004 Liaoning, ChinaHailong ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5161008 Thu, 18 Aug 2011 05:59:42 +0100 5161008 Treatment strategies and prognostic factors of patients with primary germ cell tumors in the mediastinum http://www.medworm.com/index.php?rid=5161009&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm4301g07210743g6%2F Conclusions  Primary mediastinal germ cell tumor is rare with a dominant frequency in young male patients. Chemotherapy combined with local therapy like surgery or radiotherapy is a reasonable treatment strategy recommended. Extension and initial remission rate are independent prognostic factors. Content Type Journal ArticleCategory Original PaperPages 1-6DOI 10.1007/s00432-011-1028-7Authors Ting Zhi Liu, Cancer Center, Sun Yat-Sen University, No.651, Dongfeng Rd., Guangzhou, 510060 Guangdong Province, ChinaDong Sheng Zhang, Cancer Center, Sun Yat-Sen University, No.651, Dongfeng Rd., Guangzhou, 510060 Guangdong Province, ChinaYing Liang, Cancer Center, Sun Yat-Sen University, No.651, Dongfeng Rd., Guangzhou, 510060 Guangdong Province, ChinaNing Ning Zhou, Cancer Cen... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5161009 Thu, 18 Aug 2011 05:59:41 +0100 5161009 Efficacy and safety of CHG regimen (low-dose cytarabine, homoharringtonine with G-CSF priming) as induction chemotherapy for elderly patients with high-risk MDS or AML transformed from MDS http://www.medworm.com/index.php?rid=5161010&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1518324nhp6tn630%2F Conclusions  These data suggest that the CHG priming regimen is effective and safe as a novel induction therapy for elderly patients with high-risk MDS and MDS–AML. The results need to be conformed in further study involving a larger cohort of patients. Content Type Journal ArticleCategory Original PaperPages 1-7DOI 10.1007/s00432-011-1020-2Authors Lingyun Wu, Department of Hematology, The Sixth Hospital Affiliated to Shanghai Jiaotong University, Shanghai, 200233 ChinaXiao Li, Department of Hematology, The Sixth Hospital Affiliated to Shanghai Jiaotong University, Shanghai, 200233 ChinaJiying Su, Department of Hematology, The Sixth Hospital Affiliated to Shanghai Jiaotong University, Shanghai, 200233 ChinaQi He, Department of Hematology, The Sixth Hospital Affiliat... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5161010 Tue, 16 Aug 2011 06:19:28 +0100 5161010 GPx-1 polymorphism (rs1050450) contributes to tumor susceptibility: evidence from meta-analysis http://www.medworm.com/index.php?rid=5131693&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj9t333t330w20886%2F Conclusion  These results suggest that the GPx-1 Pro198Leo polymorphism contributes to cancer susceptibility through a disturbed antioxidant balance. Content Type Journal ArticlePages 1-9DOI 10.1007/s00432-011-1033-xAuthors Jiawei Chen, Department of Urology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029 ChinaQiang Cao, Department of Urology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029 ChinaChao Qin, Department of Urology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029 ChinaPengfei Shao, Department of Urology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029 ChinaYilong ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5131693 Sat, 13 Aug 2011 06:05:14 +0100 5131693 Zoledronic acid combined with chemotherapy bring survival benefits to patients with bone metastases from nasopharyngeal carcinoma http://www.medworm.com/index.php?rid=5131694&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr467rpr41128w382%2F Conclusions  ZA treatment combined with chemotherapy could reduce SREs and improve PFS and OS for NPC patients with bone metastases. Content Type Journal ArticlePages 1-7DOI 10.1007/s00432-011-1027-8Authors Ying Jin, State Key Laboratory of Oncology in South China and Department of Medical Oncology, Sun Yat-sen University Cancer Center, 651 Dongfeng East Road, Guangzhou, 510060 ChinaXin An, State Key Laboratory of Oncology in South China and Department of Medical Oncology, Sun Yat-sen University Cancer Center, 651 Dongfeng East Road, Guangzhou, 510060 ChinaYu Chen Cai, State Key Laboratory of Oncology in South China and Department of Medical Oncology, Sun Yat-sen University Cancer Center, 651 Dongfeng East Road, Guangzhou, 510060 ChinaYe Cao, State Key Laboratory of Onco... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5131694 Sat, 13 Aug 2011 06:05:13 +0100 5131694 Targeting glucosylceramide synthase sensitizes imatinib-resistant chronic myeloid leukemia cells via endogenous ceramide accumulation http://www.medworm.com/index.php?rid=5131695&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg7j78m525x1584h8%2F Conclusion  Our data suggest the involvement of GCS in resistance to imatinib-induced apoptosis, and that targeting GCS by PDMP increased imatinib-induced cell death in drug-sensitive and drug-resistant K562 cells via enhancing ceramide accumulation. Content Type Journal ArticlePages 1-10DOI 10.1007/s00432-011-1016-yAuthors Yusuf Baran, Department of Molecular Biology and Genetics, Izmir Institute of Technology, Faculty of Science, Gulbahce Campus, 35430 Urla, Izmir, TurkeyJacek Bielawski, Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USAUfuk Gunduz, Department of Biology, Middle East Technical University, 06531 Ankara, TurkeyBesim Ogretmen, Department of Biochemistry and Molecular Biology, Medical Univer... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5131695 Thu, 11 Aug 2011 06:02:47 +0100 5131695 Cancer-derived matrix metalloproteinase-9 contributes to tumor tolerance http://www.medworm.com/index.php?rid=5131696&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp778q4723w1g0477%2F Conclusions  This study reveals a novel mechanism in tumor tolerance in which MMP9 plays a critical role in tumor survival. The data imply that MMP9 may be a potential target in the treatment of malignant tumors. Content Type Journal ArticlePages 1-9DOI 10.1007/s00432-011-1010-4Authors Bin-Quan Wang, Department of Otolaryngology, Head and Neck Surgery, The First Hospital, Shanxi Medical University, Taiyuan, Shanxi, ChinaChun-Ming Zhang, Department of Otolaryngology, Head and Neck Surgery, The First Hospital, Shanxi Medical University, Taiyuan, Shanxi, ChinaWei Gao, Department of Otolaryngology, Head and Neck Surgery, The First Hospital, Shanxi Medical University, Taiyuan, Shanxi, ChinaXu-Feng Wang, Department of Otolaryngology, Head and Neck Surgery, The First Hospita... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5131696 Thu, 11 Aug 2011 06:02:46 +0100 5131696 Molecular mechanisms of A3 adenosine receptor-induced G1 cell cycle arrest and apoptosis in androgen-dependent and independent prostate cancer cell lines: involvement of intrinsic pathway http://www.medworm.com/index.php?rid=5126093&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc7t1352640598701%2F Conclusion  This study introduces a possible mechanism through A3 adenosine receptor activation. IB-MECA inhibited prostate cancer cells proliferation and induced G1 cell cycle arrest through p53, Cdk4/cyclinD1 pathway. Apoptosis determined by characteristic morphological changes and increased in sub-G1 population. Loss of MMP, activation of caspase-3 and down-regulation of Bcl-2 expression indicated mitochondrial signaling pathway that involved in the apoptosis. Content Type Journal ArticlePages 1-13DOI 10.1007/s00432-011-1031-zAuthors Mahmoud Aghaei, Department of Clinical Biochemistry, Cancer Research Laboratory, School of Medical Science, Tarbiat Modares University, P.O. Box: 14115-331, Tehran, IranMojtaba Panjehpour, Department of Clinical Biochemistry, School ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5126093 Wed, 10 Aug 2011 15:49:35 +0100 5126093 Response and prognosis of taxanes and anthracyclines neoadjuvant chemotherapy in patients with triple-negative breast cancer http://www.medworm.com/index.php?rid=5126094&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3m4l155x772u5224%2F Conclusion  Patients with TNBC were more sensitive to neoadjuvant docetaxel plus epirubicin chemotherapy. Compared with non-TNBC patients, TNBC patients had increased pCR rate, but were associated with significantly worse survival. Content Type Journal ArticlePages 1-6DOI 10.1007/s00432-011-1029-6Authors Jiannan Wu, Department of Breast Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiangxi Road, Guangzhou, 510120 People’s Republic of ChinaShunrong Li, Department of Breast Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiangxi Road, Guangzhou, 510120 People’s Republic of ChinaWeijuan Jia, Department of Breast Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiangxi Road, Guangzhou, 510120 People... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5126094 Wed, 10 Aug 2011 15:49:31 +0100 5126094 Second-line chemotherapy with paclitaxel and doxifluridine after failure of S-1 in elderly patients with unresectable advanced or recurrent gastric cancer http://www.medworm.com/index.php?rid=5126095&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj514802l23855h46%2F Conclusion  Although it remains unclear whether second-line chemotherapy contributes to survival in patients with URGC, the combination of PTX plus 5′-DFUR might be the treatment of choice for second-line chemotherapy in both elderly and nonelderly patients who have already received an S-1-based first-line treatment. Content Type Journal ArticlePages 1-6DOI 10.1007/s00432-011-1025-xAuthors Tomomi Yakabe, Department of Surgery, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga, 849-8501 JapanHirokazu Noshiro, Department of Surgery, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga, 849-8501 JapanOsamu Ikeda, Department of Surgery, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga, 849-8501 JapanAtsushi Miyoshi, Department of Surgery, Fa... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5126095 Wed, 10 Aug 2011 15:49:30 +0100 5126095 Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: 7-year follow-up of a rare clinicopathologic syndrome http://www.medworm.com/index.php?rid=5126096&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5g8743t87wn125x3%2F Conclusions  The neuroendocrine cell hyperplasia is confined to the airway mucosa without penetration through the basement membrane and appears in a diffuse pattern, generally in close association with obliterative bronchiolar fibrosis. DIPNECH is characterized by a mixed obstructive and/or restrictive ventilation pattern with bilateral reticulonodular infiltrates and a predilection for middle-aged women. Little is known about the clinical course and treatment for DIPNECH. Content Type Journal ArticlePages 1-4DOI 10.1007/s00432-011-1015-zAuthors R. F. Falkenstern-Ge, Mittlere Ring Str. 81, 70839 Gerlingen, GermanyM. Kimmich, Division of Pulmonology, Klinik Schillerhoehe, Center for Pulmonology and Thoracic Surgery, Teaching Hospital of the University of Tuebingen, S... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5126096 Tue, 09 Aug 2011 05:43:48 +0100 5126096 Down-regulation of TWIST decreases migration and invasion of laryngeal carcinoma Hep-2 cells by regulating the E-cadherin, N-cadherin expression http://www.medworm.com/index.php?rid=5119636&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl80172t2h848r240%2F Conclusions  Down-regulation of TWIST expression decreases migration and invasion of laryngeal carcinoma Hep-2 cells by regulation of the E-cadherin, N-cadherin expression. Content Type Journal ArticlePages 1-7DOI 10.1007/s00432-011-1023-zAuthors Liang Yu, Department of Otolaryngology-Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, 250021 Peoples’ Republic of ChinaHui-zheng Li, Department of Otolaryngology-Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, 250021 Peoples’ Republic of ChinaSu-mei Lu, Institute of Eye and Otolaryngology, Shandong Clinic Research Institute, Jinan, Peoples’ Republic of ChinaJia-jun Tian, Department of Otolaryngology-Head and Neck Surgery, Provincial Hospital Affi... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5119636 Sun, 07 Aug 2011 05:48:46 +0100 5119636 The hOGG1 gene 5′-UTR variant c.−53G>C contributes to the risk of gastric cancer but not colorectal cancer in the Chinese population http://www.medworm.com/index.php?rid=5108963&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj81w5um539613535%2F Conclusions  The variant c.−53G>C in the 5′-UTR of the hOGG1 gene is a risk factor for gastric cancer and is potentially associated with low-differentiation degree, but not with colorectal cancer, in the Chinese population. Content Type Journal ArticlePages 1-9DOI 10.1007/s00432-011-1022-0Authors Xiufang Liu, Department of Medical Genetics, Nanjing University School of Medicine, 22 Hankou Road, 210093 Nanjing, ChinaNong Xiao, Lujiang People Hospital, 32 Wenmingzhong Road, 231501 Lujiang, ChinaWenwen Guo, Department of Medical Genetics, Nanjing University School of Medicine, 22 Hankou Road, 210093 Nanjing, ChinaYijia Wu, Lujiang People Hospital, 32 Wenmingzhong Road, 231501 Lujiang, ChinaZhenming Cai, Department of Medical Genetics, Nanjing University School of ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5108963 Sat, 06 Aug 2011 05:53:26 +0100 5108963 Introduction of pro-interleukin-16 inhibits T-lymphoblastic leukemia growth in mice http://www.medworm.com/index.php?rid=5108965&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc723l3238891302p%2F Conclusions  Our data support the concept that restoration of pro-IL-16 expression in malignant T cells may have therapeutic value. Content Type Journal ArticlePages 1-5DOI 10.1007/s00432-011-1017-xAuthors Jillian Richmond, Pulmonary Center, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USAMichael Finkel, Pulmonary Center, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USAAnna Studwell, Pulmonary Center, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USAFrederic Little, Pulmonary Center, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USAWilliam Cruikshank, Pulmonary Center, Boston University School of Medicine, 72 East Concord Street, Bosto... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5108965 Fri, 05 Aug 2011 05:57:46 +0100 5108965 Interstitial lung disease associated with gemcitabine treatment in patients with non-small-cell lung cancer and pancreatic cancer http://www.medworm.com/index.php?rid=5108964&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fcn64w61253650411%2F Conclusions  Prior thoracic radiotherapy and pre-existing PF were correlated with higher ILD rate in gemcitabine-treated patients. ILD incidence did not differ between NSCLC and pancreatic cancer patients, which may be due to the differences in treatment strategy and tumour properties. Content Type Journal ArticlePages 1-7DOI 10.1007/s00432-011-1013-1Authors Shigeki Umemura, Department of Clinical Oncology, Sumitomo Besshi Hospital, 3-1 Ohji-cho, Niihama, 792-8543 JapanHiromichi Yamane, Department of Clinical Oncology, Sumitomo Besshi Hospital, 3-1 Ohji-cho, Niihama, 792-8543 JapanToshimitsu Suwaki, Department of Respiratory Medicine, Sumitomo Besshi Hospital, Niihama, JapanTsutomu Katoh, Department of Radiology, Sumitomo Besshi Hospital, Niihama, JapanTakuya Yano, D... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5108964 Fri, 05 Aug 2011 05:57:46 +0100 5108964 An immune function assay predicts post-transplant recurrence in patients with hepatocellular carcinoma http://www.medworm.com/index.php?rid=5103729&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe77hv7742217lj36%2F Conclusions  The immune function assay has the potential to assess the risk of infection and rejection in liver transplantation and to predict post-transplant tumor recurrence in recipients with HCC. Content Type Journal ArticlePages 1-9DOI 10.1007/s00432-011-1014-0Authors Jian-Wen Cheng, Department of Liver Surgery, Liver Cancer Institute, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Zhongshan Hospital, Fudan University, 180 FengLin Road, Shanghai, 200032 ChinaYing-Hong Shi, Department of Liver Surgery, Liver Cancer Institute, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Zhongshan Hospital, Fudan University, 180 FengLin Road, Shanghai, 200032 ChinaJia Fan, Department of Liver Surgery, Liver Cancer In... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5103729 Tue, 02 Aug 2011 06:15:37 +0100 5103729 Lack of association between BARD1 Cys557Ser variant and breast cancer risk: a meta-analysis of 11,870 cases and 7,687 controls http://www.medworm.com/index.php?rid=5103728&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn3p5366k97u56518%2F Conclusions  This meta-analysis strongly suggests that BARD1 Cys557Ser mutation is not associated with increased breast cancer risk. Content Type Journal ArticlePages 1-6DOI 10.1007/s00432-011-1006-0Authors Da-Peng Ding, Institute of Genetic Engineering, Southern Medical University, Guangzhou, 510515 ChinaYing Zhang, College of Pharmacy, Jinan University, Guangzhou, 510632 ChinaWen-Li Ma, Institute of Genetic Engineering, Southern Medical University, Guangzhou, 510515 ChinaXiao-Feng He, Central Laboratory, Peace Hospital of Changzhi Medical College, Shanxi, ChinaWei Wang, Biomedical Imaging Research Center, University of Fukui, Eiheiji, Fukui 910-1193, JapanHai-Lang Yu, Institute of Genetic Engineering, Southern Medical University, Guangzhou, 510515 ChinaYu-Bo Guo, Ins... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5103728 Tue, 02 Aug 2011 06:15:37 +0100 5103728 A monoclonal antibody targeted against epidermal growth factor receptor variant III enhances cisplatin efficiency http://www.medworm.com/index.php?rid=5103727&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7331pl6p3l5329q5%2F Conclusions  We conclude that CH12 antibody is a promising candidate for clinical therapy for ovarian cancer cells, which has lower sensitivity to cisplatin treatment; however, the underlying mechanism needs further study. Content Type Journal ArticlePages 1-7DOI 10.1007/s00432-011-1018-9Authors Na Li, Department of Obstetrics and Gynecology, Medical School of Fudan University, Shanghai, 200032 ChinaYuanyuan Chu, Department of Gynecology, Second People’s Hospital of Kunshan, Jiangsu, 215300 ChinaLiangqing Yao, Department of Obstetrics and Gynecology, Medical School of Fudan University, Shanghai, 200032 ChinaXiaojun Ying, Department of Gynecology, Second People’s Hospital of Kunshan, Jiangsu, 215300 ChinaHua Jiang, State Key Laboratory of Oncogenes and Related Gene... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5103727 Tue, 02 Aug 2011 06:15:37 +0100 5103727 Augmentation of T-cell immune responses and signal transduction proteins in oral cancer patients: potential for IL-2-mediated immunotherapy http://www.medworm.com/index.php?rid=5103730&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw03567t257371g71%2F Conclusions  The results suggest IL-2 to augment T-cell responses in a proportion of oral cancer patients with poor response to conventional therapy. IL-2 immunotherapy can be thought of as a personalized adjuvant therapy for oral cancer following the in vitro identification of IL-2 responders using the expression of TCRζ and ZAP-70 as biomarkers. Content Type Journal ArticlePages 1-10DOI 10.1007/s00432-011-1012-2Authors Vino T. Cheriyan, Division of Cancer Research, Regional Cancer Centre, Trivandrum, Kerala, IndiaCessal Thomas, Division of Radiation Oncology, Regional Cancer Centre, Trivandrum, Kerala, IndiaPrabha Balaram, Division of Cancer Research, Regional Cancer Centre, Trivandrum, Kerala, India Journal Journal of Cancer Research and Clinical OncologyO... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5103730 Tue, 02 Aug 2011 06:15:35 +0100 5103730 Cell death-inducing effect of novel palladium(II) and platinum(II) complexes on non-small cell lung cancer cells in vitro http://www.medworm.com/index.php?rid=5103731&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd11l67822n8l664r%2F Conclusions  Novel Pd(II) complex ([PdCl(terpy)](sac)·2H2O) seems to represent a potentially active drug against non-small cell lung cancer cell lines, and further studies in vivo are warranted. Content Type Journal ArticlePages 1-10DOI 10.1007/s00432-011-1021-1Authors Engin Ulukaya, Department of Clinical Biochemistry, Medical School, Uludag University, 16059 Bursa, TurkeyFerda Ari, Department of Biology, Faculty of Arts and Sciences, Uludag University, Bursa, TurkeyKonstantinos Dimas, Department of Pharmacology, School of Medicine, University of Thessaly, Biopolis, Larisa, GreeceMehmet Sarimahmut, Department of Biology, Faculty of Arts and Sciences, Uludag University, Bursa, TurkeyEmel Guney, Department of Chemistry, Faculty of Arts and Sciences, Uludag University,... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5103731 Tue, 02 Aug 2011 06:15:33 +0100 5103731 Correlation between the expression of the BAG-1 gene and clinicopathologic factors in colorectal cancer http://www.medworm.com/index.php?rid=5103732&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv2p41u36677053x3%2F Conclusion  Bag-1 protein was found to be overexpressed in colorectal cancer. They might be regarded as a biomarker for the diagnosis of the early stages of colorectal cancer. In addition, they have particular significance for the prognosis of colorectal cancer. Content Type Journal ArticlePages 1-6DOI 10.1007/s00432-011-1011-3Authors Nian-Feng Sun, Department of the Surgery, Jinan Central Hospital of Shandong University, Jinan, ChinaQing-Yi Meng, Department of the Surgery, Jinan Central Hospital of Shandong University, Jinan, ChinaSan-Yuan Hu, Department of General Surgery, Qilu Hospital of Shandong University, Jinan, 250012 ChinaAi-Ling Tian, Department of the Surgery, Jinan Central Hospital of Shandong University, Jinan, ChinaRui-Hua Wang, Department of the Surgery... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5103732 Tue, 02 Aug 2011 06:15:32 +0100 5103732 Synergistic interaction between sunitinib and docetaxel is sequence dependent in human non–small lung cancer with EGFR TKIs-resistant mutation http://www.medworm.com/index.php?rid=5087225&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F776k235l36354pgj%2F Conclusions  Sunitinib as a single agent exhibits anti-proliferative effects in vitro in NSCLC cell lines with EGFR T790M and K-ras mutations but the sequential administration of docetaxel followed by sunitinib is superior to sunitinib followed by docetaxel and concurrent administration. Content Type Journal ArticlePages 1-12DOI 10.1007/s00432-011-1009-xAuthors Feng Pan, Department of Oncology, The First Affiliated Hospital of Anhui Medical University, No. 218, Ji Xi Road, Hefei, 230022 ChinaJing Tian, Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, No. 81, Mei Shan Road, Hefei, 230032 ChinaXuchao Zhang, Guangdong Lung Cancer Institute, Medical Research Center of Guangdong General Hospital, Guangdong Academy of Medical... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5087225 Wed, 27 Jul 2011 18:48:23 +0100 5087225 Chinese guidelines for the diagnosis and comprehensive treatment of hepatic metastasis of colorectal cancer http://www.medworm.com/index.php?rid=5087226&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F473722334443v6m3%2F Content Type Journal ArticlePages 1-18DOI 10.1007/s00432-011-0999-8Authors Jianmin Xu, Zhongshan Hospital, Fudan University, Shanghai, ChinaXinyu Qin, Zhongshan Hospital, Fudan University, Shanghai, ChinaJianping Wang, No. 6 Hospital, Zhongshan University, Guangzhou, ChinaSuzhan Zhang, No. 2 Hospital, Zhejiang Medical, Hangzhou, ChinaYunshi Zhong, Zhongshan Hospital, Fudan University, Shanghai, ChinaLi Ren, Zhongshan Hospital, Fudan University, Shanghai, ChinaYe Wei, Zhongshan Hospital, Fudan University, Shanghai, ChinaShaochong Zeng, Zhongshan Hospital, Fudan University, Shanghai, ChinaDeseng Wan, Tumor Hospital, Zhongshan University, Guangzhou, ChinaShu Zheng, No. 2 Hospital, Zhejiang Medical, Hangzhou, China Journal Journal of Cancer Research and Clinical OncologyOnline ISSN ... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5087226 Wed, 27 Jul 2011 15:50:04 +0100 5087226 Expression of cathepsin D and E-cadherin in primary laryngeal cancers correlation with neck lymph node involvement http://www.medworm.com/index.php?rid=5087228&cid=s_33343_6_f&fid=33343&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv621545mw5022675%2F Conclusion  Neck metastasis was found higher in E-Cad reduced group than positive group. Neck node metastasis was significantly higher in Cath-D positive group than Cath-D negative group. Cath-D and E-Cad essays may useful in identifying neck lymph node involvement. Cath-D expression levels are more in this predictive factor than E-Cad levels for possibility of neck lymph node metastasis in LSCC. Content Type Journal ArticlePages 1-7DOI 10.1007/s00432-011-1007-zAuthors Mustafa Paksoy, Kartal Training and Research Hospital, Kartal, TurkeyUmit Hardal, Kartal Training and Research Hospital, Kartal, TurkeyCakır Caglar, Kartal Training and Research Hospital, Kartal, Turkey Journal Journal of Cancer Research and Clinical OncologyOnline ISSN 1432-1335Print ISSN 017... Journal of Cancer Research and Clinical Oncology journals http://www.medworm.com/rss/comments.php?id=5087228 Tue, 26 Jul 2011 05:54:04 +0100 5087228