Journal of Cardiac Failure via MedWorm.com

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Journal of Cardiac Failure — Wed, 01 Feb 2012 05:00:00 +0100

(Source: Journal of Cardiac Failure)

Journal of Cardiac Failure — Wed, 01 Feb 2012 05:00:00 +0100

(Source: Journal of Cardiac Failure)

Masthead

Journal of Cardiac Failure — Wed, 01 Feb 2012 05:00:00 +0100

(Source: Journal of Cardiac Failure)

Editorial Board

Journal of Cardiac Failure — Wed, 01 Feb 2012 05:00:00 +0100

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Erratum

Journal of Cardiac Failure — Wed, 01 Feb 2012 05:00:00 +0100

The article “Flexible Diuretic Titration in Chronic Heart Failure: Where Is the Evidence?” (J Card Fail 2011;17:944-54), was published with a misspelling to an author's name in reference 5. The correct reference listing is: Metra M, Teerlink JR, Felker GM, Greenberg BH, Filippatos G, Ponikowski P, Teichman SL, Unemori E, Voors AA, Weatherley BD, Cotter G. Dyspnoea and worsening heart failure in patients with acute heart failure: results from the Pre-RELAX-AHF study. Eur J Heart Fail 2010;12:1130-9. (Source: Journal of Cardiac Failure)

Indications for Cardiac Resynchronization Therapy: 2011 Update From the Heart Failure Society of America Guideline Committee

Journal of Cardiac Failure — Wed, 01 Feb 2012 05:00:00 +0100

Abstract: Cardiac resynchronization therapy (CRT) improves survival, symptoms, quality of life, exercise capacity, and cardiac structure and function in patients with New York Heart Association (NYHA) functional class II or ambulatory class IV heart failure (HF) with wide QRS complex. The totality of evidence supports the use of CRT in patients with less severe HF symptoms. CRT is recommended for patients in sinus rhythm with a widened QRS interval (≥150 ms) not due to right bundle branch block (RBBB) who have severe left ventricular (LV) systolic dysfunction and persistent NYHA functional class II-III symptoms despite optimal medical therapy (strength of evidence A). CRT may be considered for several other patient groups for whom evidence of benefit is clinically significant but less su...

The Heart Failure Society of America in 2020: A Vision for the Future

Journal of Cardiac Failure — Wed, 01 Feb 2012 05:00:00 +0100

In 1994 Dr. Jay Cohn and other leaders in cardiovascular disease met in New York city to explore the possibility of establishing a professional society that could channel the rapidly growing interest in the nascent field of heart failure into an effective force for improving patient care. The preceding 2 decades had been marked by unprecedented insights into the underlying pathophysiology of cardiac dysfunction that were paralleled by therapeutic advances that, for the first time, were shown to clearly improve outcomes in heart failure patients. At the same time, heart failure prevalence was rapidly increasing throughout the world because of the aging of the population, improved survival of patients with myocardial infarction and other cardiac conditions, and inadequate treatment of common...

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Journal of Cardiac Failure — Wed, 28 Dec 2011 05:54:38 +0100

(Source: Journal of Cardiac Failure)

Journal of Cardiac Failure — Wed, 28 Dec 2011 05:54:38 +0100

(Source: Journal of Cardiac Failure)

Masthead

Journal of Cardiac Failure — Wed, 28 Dec 2011 05:54:38 +0100

(Source: Journal of Cardiac Failure)

Editorial Board

Journal of Cardiac Failure — Wed, 28 Dec 2011 05:54:38 +0100

(Source: Journal of Cardiac Failure)

Echocardiographic Evaluation of Left Ventricular Structure and Function: New Modalities and Potential Applications in Clinical Trials

Journal of Cardiac Failure — Mon, 26 Dec 2011 05:00:00 +0100

Abstract: Advances in modern echocardiography for quantification of cardiac structure and function have not been translated in clinical trial or practice applications to date. Imaging endpoints are especially well-suited for early trials with investigational therapies for heart failure as most drugs and devices approved for heart failure have shown favorable effects on cardiac structure and function also. Echocardiography is versatile and can be performed in most clinical settings. The modest interobserver and test-retest reproducibility of specific structural and functional parameters with conventional echocardiography can be improved on by using contemporary modalities, including 3-dimensional (3D) echocardiography for assessment of volumes and ejection fraction and speckle tracking for ...

Survival Benefit of Implantable Cardioverter-Defibrillators in Left Ventricular Assist Device–Supported Heart Failure Patients

Journal of Cardiac Failure — Mon, 26 Dec 2011 05:00:00 +0100

Conclusions: Shock frequency decreases after VAD implantation, likely owing to ventricular unloading, but appropriate ICD shocks still occur in 21% of patients. An ICD is associated with improved survival in LVAD-supported HF patients. (Source: Journal of Cardiac Failure)

Impact of Ventricular Dyssynchrony on Postexercise Accommodation of Systolic Myocardial Motion in Hypertensive Patients With Heart Failure and a Normal Ejection Fraction: A Tissue-Doppler Echocardiography Study

Journal of Cardiac Failure — Mon, 26 Dec 2011 05:00:00 +0100

Conclusions: Dyssynchrony-related regional myocardial contractile abnormality after exercise in HFNEF patients suggested the detrimental impact of electromechanical uncoupling on HF symptoms. (Source: Journal of Cardiac Failure)

Change in Intrathoracic Impedance Measures During Acute Decompensated Heart Failure Admission: Results From the Diagnostic Data for Discharge in Heart Failure Patients (3D-HF) Pilot Study

Journal of Cardiac Failure — Mon, 26 Dec 2011 05:00:00 +0100

Conclusions: Intrathoracic impedance changes were evident over a short duration in the majority of patients admitted for ADHF and may be a potential criterion for discharge readiness. (Source: Journal of Cardiac Failure)

On Being Smart

Journal of Cardiac Failure — Mon, 26 Dec 2011 05:00:00 +0100

There is generally a positive relationship between intelligence, as measured by Intelligence Quotient testing, and success in later life. This relationship tapers off as a function of time. Being smart usually means that one can figure things out by grappling with facts and numbers and by using deductive reasoning. Analytic thought allows one to come to a reasonably clear understanding of a complex problem. Lots of people are very smart. We work with them on a daily basis. (Source: Journal of Cardiac Failure)

Cardiac Resynchronization Therapy in the Real World: Comparison With the COMPANION Study

Journal of Cardiac Failure — Mon, 05 Dec 2011 05:00:00 +0100

Conclusions: Survival and CV hospitalization outcomes in a real-world clinical setting are as good as, or better than, those demonstrated in the COMPANION research trial. (Source: Journal of Cardiac Failure)

Progressive Rise in Red Cell Distribution Width Is Associated With Disease Progression in Ambulatory Patients With Chronic Heart Failure

Journal of Cardiac Failure — Mon, 05 Dec 2011 05:00:00 +0100

Conclusions: In our ambulatory cohort of patients with chronic heart failure, baseline and serial increases in RDW were associated with poor long-term outcomes independently from standard cardiac, hematologic, and renal indices. (Source: Journal of Cardiac Failure)

Coincidence of Apical Ballooning Syndrome (Tako-Tsubo/Stress Cardiomyopathy) and Posterior Reversible Encephalopathy Syndrome: Potential Common Substrate and Pathophysiology?

Journal of Cardiac Failure — Mon, 05 Dec 2011 05:00:00 +0100

Conclusions: ABS and PRES can occur simultaneously during an acute illness. Patients with ABS who develop neurologic dysfunction should be evaluated for PRES and vice versa. Because transient sympathetic overactivity and microvascular dysfunction have been observed in both reversible syndromes, we speculate that they may represent the shared pathophysiologic mechanism. (Source: Journal of Cardiac Failure)

Trastuzumab Adjuvant Chemotherapy and Cardiotoxicity in Real-World Women With Breast Cancer

Journal of Cardiac Failure — Mon, 05 Dec 2011 05:00:00 +0100

Abstract: Background: Adjuvant trastuzumab therapy improves survival of human epidermal growth factor receptor 2 (HER2)–positive women with early breast cancer (EBC). A careful monitoring of cardiac function is needed due to potential trastuzumab cardiotoxicity (Tcardiotox). To date, the incidence, timing, and phenotype of patients with Tcardiotox in clinical practice are not well known.Methods and Results: A total of 499 consecutive HER2-positive women (mean age 55 ± 11 years) with EBC treated with trastuzumab between January 2008 and June 2009 at 10 Italian institutions were followed for 1 year. We evaluated incidence, time of occurrence, and clinical features associated with Tcardiotox. Left ventricular ejection fraction (LVEF) was evaluated by echocardiography at baseline and at 3, ...

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Journal of Cardiac Failure — Thu, 01 Dec 2011 02:43:43 +0100

(Source: Journal of Cardiac Failure)

Journal of Cardiac Failure — Thu, 01 Dec 2011 02:43:43 +0100

(Source: Journal of Cardiac Failure)

Masthead

Journal of Cardiac Failure — Thu, 01 Dec 2011 02:43:43 +0100

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Editorial Board

Journal of Cardiac Failure — Thu, 01 Dec 2011 02:43:43 +0100

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Acknowledgment of Reviewers

Journal of Cardiac Failure — Thu, 01 Dec 2011 02:43:43 +0100

(Source: Journal of Cardiac Failure)

The Cardiorenal Syndrome: Should Change Make Us Uncomfortable?

Journal of Cardiac Failure — Thu, 01 Dec 2011 02:43:43 +0100

Cardiorenal interaction in heart failure is poorly understood. It is well established that the presence of chronic kidney disease increases mortality in patients with heart failure. Furthermore, several studies have demonstrated that worsening renal function (WRF) during the treatment of acute decompensated heart failure leads to inadequate resolution of congestion, recurrent hospitalizations, and increased mortality. Diuretics remain the mainstay of acute heart failure therapy but have been shown to contribute to the development of WRF, especially when administered in high doses. Therefore, the efforts of the heart failure community have focused on finding alternative therapies that allow freedom from congestion without precipitating WRF. Several novel therapies, including nesiritide, vas...

Controlling the Flood Gates: Vaptans, Furosemide and the Quest for a Renal Protective Diuresis

Journal of Cardiac Failure — Thu, 01 Dec 2011 02:43:42 +0100

Retention of sodium and water are hallmarks of the heart failure (HF) syndrome, and renal dysfunction is a strong and independent predictor of adverse outcomes in HF patients. Given the persisting substantial morbidity and mortality of HF, there has been concern that current diuretic strategies to manage fluid status in HF patients may contribute to renal dysfunction and worse outcomes. Loop diuretics such as furosemide are potent saluretics and have been in use for decades, but they can result in adverse actions such as electrolyte imbalance, neurohumoral activation, and volume depletion. Nonetheless, even though they have never been formally tested in a randomized controlled trial against placebo, they continue to be a mainstay in the current pharmacologic treatment of hypervolemic patie...

High-Intensity Interval Exercise in Chronic Heart Failure: Protocol Optimization

Journal of Cardiac Failure — Mon, 28 Nov 2011 05:00:00 +0100

Conclusion: Among the 4 HIIE protocols tested, protocol A with short intervals and passive recovery appeared to be superior. (Source: Journal of Cardiac Failure)

Myocardial G Protein Receptor–Coupled Kinase Expression Correlates With Functional Parameters and Clinical Severity in Advanced Heart Failure

Journal of Cardiac Failure — Mon, 28 Nov 2011 05:00:00 +0100

Conclusions: Increased GRK2 correlates with clinical severity using the INTERMACS scale and LV stroke volume, supporting it as a potential target in advanced HF. These changes are paralleled by GRK5 expression in the failing myocardium, suggesting a relevant role in human HF. (Source: Journal of Cardiac Failure)

Comorbidity Drives Mortality in Newly Diagnosed Heart Failure: A Study Among Geriatric Outpatients

Journal of Cardiac Failure — Mon, 28 Nov 2011 05:00:00 +0100

Conclusions: The majority of geriatric outpatients with new HF die within 3 years. Comorbidity, summarized in the CCI, is the strongest independent predictor of mortality. (Source: Journal of Cardiac Failure)

Long-Term Prognostic Value of CA 125 Serum Levels in Mild to Moderate Heart Failure Patients

Journal of Cardiac Failure — Thu, 10 Nov 2011 05:00:00 +0100

Conclusions: In mild-to-moderate HF patients under optimized therapy, higher plasma CA 125 levels are an effective long-term prognostic marker in forecasting cardiovascular events and HF hospitalization and may contribute to a better risk stratification. (Source: Journal of Cardiac Failure)

The “Obesity Paradox”: Does It Persist Among Israeli Patients With Decompensated Heart Failure? A Subanalysis of the Heart Failure Survey in Israel (HFSIS)

Journal of Cardiac Failure — Thu, 10 Nov 2011 05:00:00 +0100

Abstract: Background: Earlier studies among heart failure (HF) patients reported a paradox of reduced mortality rates in those with increased body mass index (BMI). Recently, however, it has been shown that obesity was not associated with better prognosis in certain groups. The aim of this study was to evaluate the “obesity paradox” among patients included in the Heart Failure Survey in Israel (HFSIS).Methods and Results: Clinical, demographic, and laboratory characteristics of 2,323 patients hospitalized with a diagnosis of acute or decompensated chronic HF in 25 public Israeli hospitals between March 1 and April 30, 2003, were categorized by BMI as: normal weight (18.5–24.9 kg/m2; n = 837), overweight (25.0–29.9 kg/m2; n = 877), or obese (≥30.0 kg/m2; n = 574), excluding 35 ...

Comorbid Diabetes and End-of-Life Expenditures Among Medicare Beneficiaries With Heart Failure

Journal of Cardiac Failure — Thu, 10 Nov 2011 05:00:00 +0100

Conclusions: Comorbid diabetes was common in heart failure and associated with higher expenditures, much of which was driven by increased rates of hospitalizations. Programs that focus on prevention of hospitalizations may reduce the substantial costs associated with heart failure near the end of life. (Source: Journal of Cardiac Failure)

Relationship Between Diastolic Function and Heart Rate Recovery After Symptom-Limited Exercise

Journal of Cardiac Failure — Thu, 10 Nov 2011 05:00:00 +0100

Conclusions: Diastolic dysfunction is independently associated with abnormal HR recovery after symptom-limited exercise. Further studies are needed to determine if diastolic function modifies the adverse outcomes observed in those with abnormal HR recovery. (Source: Journal of Cardiac Failure)

Myocardial Recovery in Peripartum Cardiomyopathy: Prospective Comparison With Recent Onset Cardiomyopathy in Men and Nonperipartum Women

Journal of Cardiac Failure — Thu, 10 Nov 2011 05:00:00 +0100

Conclusions: Prospective evaluation confirms myocardial recovery is greatest in women with PPCM, poorest in men, and intermediate in nonperipartum women. On contemporary therapy, nearly half of women with PPCM normalize cardiac function by 6 months. (Source: Journal of Cardiac Failure)

Cognitive Therapy Improves Three-Month Outcomes in Hospitalized Patients With Heart Failure

Journal of Cardiac Failure — Thu, 10 Nov 2011 05:00:00 +0100

Conclusion: Nurses can deliver a brief intervention to hospitalized patients with heart failure that may improve short-term, event-free survival. Future research is needed to verify these results with a larger sample size. (Source: Journal of Cardiac Failure)

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Journal of Cardiac Failure — Tue, 01 Nov 2011 04:00:00 +0100

(Source: Journal of Cardiac Failure)

Journal of Cardiac Failure — Tue, 01 Nov 2011 04:00:00 +0100

(Source: Journal of Cardiac Failure)

Masthead

Journal of Cardiac Failure — Tue, 01 Nov 2011 04:00:00 +0100

(Source: Journal of Cardiac Failure)

Editorial Board

Journal of Cardiac Failure — Tue, 01 Nov 2011 04:00:00 +0100

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Intrathoracic Impedance Monitoring, Audible Patient Alerts, and Outcome in Patients With Heart Failure

Journal of Cardiac Failure — Tue, 01 Nov 2011 04:00:00 +0100

This abstract has been published in manuscript form in the October 18 issue of Circulation (Circulation. 2011; 124: 1719-1726). Heart failure is associated with frequent hospitalizations, often resulting from volume overload. Measurement of intrathoracic impedance with an implanted device with an audible patient alert may detect increases in pulmonary fluid retention early. We hypothesized that early intervention could prevent hospitalizations and affect outcome. (Source: Journal of Cardiac Failure)

Surgical Treatment of Ischemic Heart Failure Trial

Journal of Cardiac Failure — Tue, 01 Nov 2011 04:00:00 +0100

The Surgical Treatment for Ischemic Heart Failure (STICH) randomized trial compared coronary artery bypass surgery plus medical therapy (CABG) with medical therapy alone (MED) in 1,212 patients with left ventricular ejection fraction ≤ 0.35 and coronary artery disease. Primary clinical results were published in April 2011, and showed that CABG resulted in no statistically significant difference in all-cause mortality after a median follow-up of 56 months (P=0.12). Quality of life outcomes are a major secondary endpoint of STICH. (Source: Journal of Cardiac Failure)

Clinical Outcomes at 180 days in the ASCEND-HF Trial: Double-Blind, Placebo-Controlled, Multicenter Acute Study of Clinical Effectiveness of Nesiritide in Subjects With Decompensated Heart Failure

Journal of Cardiac Failure — Tue, 01 Nov 2011 04:00:00 +0100

ASCEND-HF randomized patients with Acute Decompensated Heart Failure (ADHF) at 348 sites globally. This was a randomized, double-blind, placebo-controlled, parallel-group, multicenter study to evaluate the efficacy and safety of nesiritide administered in addition to standard care compared with placebo administered in addition to standard care in subjects with ADHF. The primary endpoint was all cause 30 day mortality, heart failure readmissions and change in dyspnea judged by a Likert scale at 6 and 24 hours. The 30 day outcomes have been presented and published. A follow up phase included a telephone contact at Day 180. (Source: Journal of Cardiac Failure)

Treatment of acute decompensated heart failure with the soluble guanylate cyclase activator cinaciguat: The COMPOSE program – three randomized, controlled, phase IIb studies

Journal of Cardiac Failure — Tue, 01 Nov 2011 04:00:00 +0100

Cinaciguat (BAY 58-2667) is in clinical development as a novel treatment for acute decompensated heart failure (ADHF). It directly activates soluble guanylate cyclase, a key enzyme in the nitric oxide signaling pathway, independently of nitric oxide. Importantly, its potency is increased under conditions of oxidative stress, which are characteristic of cardiovascular disease. Cinaciguat showed cardioprotective effects in animal models. In a pilot clinical study in patients with ADHF it was well tolerated, but a phase II study was prematurely terminated because of hypotensive events that exceeded acceptable levels in patients receiving doses ≥ 200 μg/h. However, no adverse effect on 30-day mortality was observed. (Source: Journal of Cardiac Failure)

The Evidence Base for Diuretic Therapy

Journal of Cardiac Failure — Tue, 01 Nov 2011 04:00:00 +0100

Oh to have such a simple equation to assist in the determination of appropriate diuretic regimens. Although this “law” was written >30 years ago, it seems as if the evidence for managing diuretics has not advanced much beyond this humorous attempt to quickly treat edema in elderly patients. (Source: Journal of Cardiac Failure)

Flexible Diuretic Titration in Chronic Heart Failure: Where Is the Evidence?

Journal of Cardiac Failure — Tue, 01 Nov 2011 04:00:00 +0100

Conclusions: To date, only 2 randomized clinical studies were identified that were designed to determine the effects of a flexible diuretic dosing regimen in outpatient HF patients with reduced ejection fraction. Data are lacking in HF patients with preserved ejection fraction. There is a critical need to test this strategy in well designed prospective randomized clinical trials. (Source: Journal of Cardiac Failure)

Iron Deficiency Predicts Impaired Exercise Capacity in Patients With Systolic Chronic Heart Failure

Journal of Cardiac Failure — Tue, 01 Nov 2011 04:00:00 +0100

Abstract: Background: Iron is an indispensable element of hemoglobin, myoglobin, and cytochromes, and, beyond erythropoiesis, is involved in oxidative metabolism and cellular energetics. Hence, iron deficiency (ID) is anticipated to limit exercise capacity. We investigated whether ID predicted exercise intolerance in patients with systolic chronic heart failure (CHF).Methods and Results: We prospectively studied 443 patients with stable systolic CHF (age 54 ± 10 years, males 90%, ejection fraction 26 ± 7%, New York Heart Association Class I/II/III/IV 49/188/180/26). ID was defined as: serum ferritin (Source: Journal of Cardiac Failure)

Hyponatremia and Long-Term Outcomes in Chronic Heart Failure—An Observational Study From the Duke Databank for Cardiovascular Diseases

Journal of Cardiac Failure — Wed, 19 Oct 2011 04:00:00 +0100

Conclusions: Hyponatremia is relatively common in HF patients with LV dysfunction and is independently associated with increased risk of all-cause mortality and cardiovascular mortality/rehospitalization. (Source: Journal of Cardiac Failure)

Characteristics and Outcomes of Peripartum Versus Nonperipartum Cardiomyopathy in Women Using a Wearable Cardiac Defibrillator

Journal of Cardiac Failure — Wed, 19 Oct 2011 04:00:00 +0100

Conclusions: The mortality rate of 2.8% (over 3.0 ± 1.2 years) in PPCM patients is low compared to published data. The role of WCD therapy among PPCM patients deserves further study. (Source: Journal of Cardiac Failure)

Effect of a Medication-Taking Behavior Feedback Theory–Based Intervention on Outcomes in Patients With Heart Failure

Journal of Cardiac Failure — Wed, 19 Oct 2011 04:00:00 +0100

Conclusions: Use of an intervention based on the TPB improves medication adherence and outcomes in patients with HF and therefore offers promise as a clinically applicable intervention to help patients with HF to adhere to their prescribed regimen. (Source: Journal of Cardiac Failure)

Angiotensin-Converting Enzyme Inhibition Promotes Coronary Angiogenesis in the Failing Heart of Dahl Salt-Sensitive Hypertensive Rats

Journal of Cardiac Failure — Mon, 17 Oct 2011 04:00:00 +0100

Conclusions: These results indicate that ACE inhibition by perindopril promotes myocardial capillary formation as well as attenuates cardiac remodeling and failure in a manner independent from the antihypertensive effect of the drug in DS hypertensive rats. The beneficial cardiac effects of perindopril were associated with activation of the bradykinin–nitric oxide pathway in the heart. (Source: Journal of Cardiac Failure)

Patient Characteristics From a Regional Multicenter Database of Acute Decompensated Heart Failure in Asia Pacific (ADHERE International–Asia Pacific)

Journal of Cardiac Failure — Mon, 10 Oct 2011 04:00:00 +0100

Conclusions: Compared with other multicenter registries, patients hospitalized with acute HF in the Asia Pacific region tend to present with more severe clinical symptoms and signs and are younger, especially in countries at an earlier stage in their epidemiological transition. Echocardiography and disease-modifying medications are used less often, highlighting potential opportunities to improve outcomes. (Source: Journal of Cardiac Failure)

Heart Failure Is a Risk Factor for Incident Driving Cessation Among Community-Dwelling Older Adults: Findings From a Prospective Population Study

Journal of Cardiac Failure — Mon, 10 Oct 2011 04:00:00 +0100

Conclusions: HF is an independent risk factor for incident driving cessation among community-dwelling older drivers. Several patient characteristics predicted driving cessation in older HF patients, which may be targets for interventions to prevent driving cessation among these patients. (Source: Journal of Cardiac Failure)

Renal Effects of Conivaptan, Furosemide, and the Combination in Patients With Chronic Heart Failure

Journal of Cardiac Failure — Mon, 10 Oct 2011 04:00:00 +0100

Conclusions: Without adversely affecting important hemodynamic variables, neurohormones, renal blood flow, or glomerular filtration rate, conivaptan significantly augmented both the diuretic and the natriuretic response to furosemide in patients with chronic HF. These results may have implications for the design of furosemide-sparing regimens in the treatment of acute HF. (Source: Journal of Cardiac Failure)

Right Ventricular Dysfunction Compromises Accuracy of Echocardiographic Diagnosis of Pulmonary Hypertension in Heart Failure

Journal of Cardiac Failure — Wed, 05 Oct 2011 04:00:00 +0100

Abstract: Background: The Swan-Ganz catheter and echocardiography (ECHO) are commonly used to measure pulmonary artery systolic pressure. It is unknown how right ventricular dysfunction influences the accuracy of ECHO-derived estimation of pulmonary hypertension in patients with severe left ventricular systolic dysfunction.Methods and Results: We analyzed a limited-access dataset from the ESCAPE (Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness) trial provided by the National Heart, Lung, and Blood Institute. Patients enrolled in this trial had left ventricular ejection fraction (Source: Journal of Cardiac Failure)

Dynamics in Insulin Resistance and Plasma Levels of Adipokines in Patients With Acute Decompensated and Chronic Stable Heart Failure

Journal of Cardiac Failure — Wed, 05 Oct 2011 04:00:00 +0100

Conclusions: ADHF is associated with worsening of insulin resistance and elevations of adipokines and TNF-α, indicative of adipocyte activation. These metabolic abnormalities are reversible, but they temporally lag behind the clinical resolution of decompensated HF. (Source: Journal of Cardiac Failure)

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Journal of Cardiac Failure — Sat, 01 Oct 2011 04:00:00 +0100

(Source: Journal of Cardiac Failure)

Journal of Cardiac Failure — Sat, 01 Oct 2011 04:00:00 +0100

(Source: Journal of Cardiac Failure)

Masthead

Journal of Cardiac Failure — Sat, 01 Oct 2011 04:00:00 +0100

(Source: Journal of Cardiac Failure)

Editorial Board

Journal of Cardiac Failure — Sat, 01 Oct 2011 04:00:00 +0100

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Erratum

Journal of Cardiac Failure — Sat, 01 Oct 2011 04:00:00 +0100

The article “Effects of Sertraline on Circulating Markers of Oxidative Stress in Depressed Patients With Chronic Heart Failure: A Pilot Study,” by Michalakeas et al (J Card Fail 2011;17:748-54), was published with a misspelling to an author's name. The correct spelling of the author's name is Elefterios Lykouras. (Source: Journal of Cardiac Failure)

Found in Translation

Journal of Cardiac Failure — Sat, 01 Oct 2011 04:00:00 +0100

Georges Cuvier laid the foundations of reductionism in 1798 with the claim of being able to discern the entirety of an organism from the structure of a single bone. He thereby helped set in motion the slow and inexorable decline of whole-body or integrative physiology. In this issue of the Journal of Cardiac Failure, Galiwango et al report an elegant experiment relating historically established physiology of the sympathorenal axis to the treatment of congestion in human heart failure. The study is elegant both in execution and in its translation of established whole-animal physiology to human disease. The report reminds us that “translational research” includes the translation of experimentally established whole-body physiology to humans and of the critical importance of continuing cl...

Clinical Characteristics and Outcomes of Patients With Improvement in Renal Function During the Treatment of Decompensated Heart Failure

Journal of Cardiac Failure — Thu, 29 Sep 2011 04:00:00 +0100

Conclusions: IRF is associated with significantly worsened survival and may represent the resolution of venous congestion–induced preadmission WRF. Unlike WRF, the renal dysfunction in IRF patients occurs independently from the confounding effects of acute decongestion and may provide incremental information for the study of cardiorenal interactions. (Source: Journal of Cardiac Failure)

Doxercalciferol, a Pro-hormone of Vitamin D, Prevents the Development of Cardiac Hypertrophy in Rats

Journal of Cardiac Failure — Mon, 12 Sep 2011 04:00:00 +0100

Conclusions: Administration of doxercalciferol attenuated the development of HS diet induced cardiac hypertrophy and cardiac dysfunction in DSS rats. (Source: Journal of Cardiac Failure)

Myocardial Deformation Analysis in Chagas Heart Disease With the Use of Speckle Tracking Echocardiography

Journal of Cardiac Failure — Mon, 12 Sep 2011 04:00:00 +0100

Conclusion: Evaluation of myocardial deformation, particularly of RS, appears to be a sensitive technique for detection of myocardial involvement in patients in the indeterminate form and provides insights into the still unrevealed pathophysiology of Chagas heart involvement. (Source: Journal of Cardiac Failure)

Systemic Oxidative Stress and Endothelial Dysfunction is Associated With an Attenuated Acute Vascular Response to Inhaled Prostanoid in Pulmonary Artery Hypertension Patients

Journal of Cardiac Failure — Mon, 12 Sep 2011 04:00:00 +0100

Conclusion: PAH patients show increased systemic oxidative stress and endothelial dysfunction markers. Response to inhaled prostanoid is inversely related to both parameters. (Source: Journal of Cardiac Failure)

A Multicenter, Randomized, Double-blind, Placebo-controlled Study of Tolvaptan Monotherapy Compared to Furosemide and the Combination of Tolvaptan and Furosemide in Patients With Heart Failure and Systolic Dysfunction

Journal of Cardiac Failure — Mon, 12 Sep 2011 04:00:00 +0100

Conclusions: In patients with HF and signs of volume overload, TLV monotherapy without concomitant loop diuretic therapy reduced body weight when compared to placebo without adverse changes in serum electrolytes, during a sodium restricted diet while on background medications including angiotensin-converting enzyme inhibitors and β-blockers. (Source: Journal of Cardiac Failure)

Catheter Ablation for Atrial Fibrillation in Patients With Left Ventricular Systolic Dysfunction. A Systematic Review and Meta-Analysis

Journal of Cardiac Failure — Mon, 12 Sep 2011 04:00:00 +0100

Conclusions: AF ablation in patients with systolic LV dysfunction results in significant improvement of LV function, but the extent of this improvement is heterogeneous. Patients with coronary artery disease seem to benefit less than patients with other underlying diseases. These results may be explained by patient selection. (Source: Journal of Cardiac Failure)

Left Ventricular Geometry, Global Function, and Dyssynchrony in Infants and Children With Pompe Cardiomyopathy Undergoing Enzyme Replacement Therapy

Journal of Cardiac Failure — Mon, 12 Sep 2011 04:00:00 +0100

This study sought to explore detailed process of LV reverse remodeling after ERT with the use of tissue Doppler and stain rate imaging.Methods and Results: Nine infants and children with Pompe cardiomyopathy undergoing ERT for ≥1 year, as well as 36 healthy control subjects, were studied. Global systolic and diastolic function was evaluated by peak systolic and early-diastolic velocity at mitral annulus. Temporal systolic and diastolic dyssynchrony was evaluated by the coefficient of variation of the time from the QRS complex to peak systolic and early-diastolic strain rate among 12 LV segments. All pre-ERT patients had impaired global systolic and diastolic function as well as increased regional dyssynchrony (P < .001 for each of all). During the regression of LV hypertrophy, all of the...

A Cellular MicroRNA, let-7i, Is a Novel Biomarker for Clinical Outcome in Patients With Dilated Cardiomyopathy

Journal of Cardiac Failure — Mon, 12 Sep 2011 04:00:00 +0100

Conclusions: A decrease in let-7i may be related to poor clinical outcomes in patients with DCM. (Source: Journal of Cardiac Failure)

Low Systolic Blood Pressure at Admission Predicts Long-Term Mortality in Heart Failure With Preserved Ejection Fraction

Journal of Cardiac Failure — Mon, 12 Sep 2011 04:00:00 +0100

Abstract: Background: Systolic blood pressure (SBP) at hospital admission predicts in-hospital and postdischarge mortality in patients with left ventricular systolic dysfunction. The relationship between admission SBP and mortality in heart failure with preserved (≥50%) ejection fraction (HFPEF) is still unclear.Methods and Results: We aimed to investigate the relationship between admission SBP and 5-year outcome in 368 consecutive patients hospitalized for new-onset HFPEF. Five-year all-cause mortality rates according to admission SBP categories ( (Source: Journal of Cardiac Failure)

Clinical Correlates of Hemoconcentration During Hospitalization for Acute Decompensated Heart Failure

Journal of Cardiac Failure — Mon, 05 Sep 2011 04:00:00 +0100

Conclusions: Hemoconcentration is significantly associated with increased diuretic dose, greater weight loss, and increased risk of worsening renal function during hospitalization. Hemoconcentration was significantly associated with mortality in univariate analysis, but not in multivariate analysis. (Source: Journal of Cardiac Failure)

Hemodynamic Effects of Exercise Training in Heart Failure

Journal of Cardiac Failure — Mon, 05 Sep 2011 04:00:00 +0100

Conclusions: Exercise training improves peakVO2 by increasing CO with unchanged a-v O2diff. A reduction after training of a-v O2diff with an increase in CO is frequent (50% of cases), is suggestive of blood flow redistribution and, per se, not a sign of reduced muscle performance been associated with improved exercise capacity. (Source: Journal of Cardiac Failure)

Statins Do Not Significantly Affect Muscle Sympathetic Nerve Activity in Humans With Nonischemic Heart Failure: A Double-Blind Placebo-Controlled Trial

Journal of Cardiac Failure — Mon, 05 Sep 2011 04:00:00 +0100

Conclusions: Short-term statin therapy in patients with nonischemic HF does not result in a significant decrease in SNS activation as measured by MSNA. These findings are consistent with the neutral outcomes of large clinical trials of statins in HF. (Source: Journal of Cardiac Failure)

Molecular Signatures of End-Stage Heart Failure

Journal of Cardiac Failure — Mon, 05 Sep 2011 04:00:00 +0100

Conclusion: Multiple “-omic” analyses support the convergence of dramatic changes in molecular processes underlying IHD and NICM at end stage. (Source: Journal of Cardiac Failure)

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Journal of Cardiac Failure — Tue, 30 Aug 2011 13:38:23 +0100

(Source: Journal of Cardiac Failure)

Journal of Cardiac Failure — Tue, 30 Aug 2011 13:38:23 +0100

(Source: Journal of Cardiac Failure)

Masthead

Journal of Cardiac Failure — Tue, 30 Aug 2011 13:38:23 +0100

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Editorial Board

Journal of Cardiac Failure — Tue, 30 Aug 2011 13:38:23 +0100

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Erratum

Journal of Cardiac Failure — Tue, 30 Aug 2011 13:38:23 +0100

This study was conducted while Dr. Shah was on faculty at Duke University Medical Center and Columbia University Medical Center.” This statement was omitted from the author identification for the recently published paper “The STARBRITE Trial: A Randomized, Pilot Study of B-Type Natriuretic Peptide – Guided Therapy in Patients With Advanced Heart Failure” by Shah, Califf, Nohria, Bhapkar, Bowers, Mancini, Fiuzat, Stevenson, and O’Connor. (J Card Fail 2011:17;613-21). (Source: Journal of Cardiac Failure)

Hemodynamic Monitoring to Guide Treatment of Acute Heart Failure

Journal of Cardiac Failure — Tue, 30 Aug 2011 13:38:21 +0100

Go where the money is, and go there often.Willie Sutton, US bank robber (1901-1980) Large registries demonstrate that growing numbers of men and women with heart failure are admitted to the hospital with acute decompensation that requires intravenous diuretic and/or vasoactive therapy. Although use of evidence-based therapies and adherence to performance measures have improved outcomes for some, the majority remain at high risk for readmission and even death over the next 6 to 12 months. In a recent study, 42% of patients died, were rehospitalized or had an emergency room visit within 60 days. At the time of admission, several routine clinical and laboratory parameters can be used to risk stratify patients, with systolic blood pressure and measures of renal function having the strongest ...

Left Ventricular Function in Adult Patients With Atrial Septal Defect: Implication for Development of Heart Failure After Transcatheter Closure

Journal of Cardiac Failure — Fri, 19 Aug 2011 04:00:00 +0100

Abstract: Despite advances in device closure for atrial septal defect (ASD), post-closure heart failure observed in adult patients remains a clinical problem. Although right heart volume overload is the fundamental pathophysiology in ASD, the post-closure heart failure characterized by acute pulmonary congestion is likely because of age-related left ventricular diastolic dysfunction, which is manifested by acute volume loading with ASD closure. Aging also appears to play important roles in the pathophysiology of heart failure through several mechanisms other than diastolic dysfunction, including ventricular systolic and vascular stiffening and increased incidence of comorbidities that significantly affect cardiovascular function. Recent studies suggested that accurate assessment of preclos...

Body Temperature Circadian Rhythm Variability Corresponds to Left Ventricular Systolic Dysfunction in Decompensated Cardiomyopathic Hamsters

Journal of Cardiac Failure — Fri, 19 Aug 2011 04:00:00 +0100

Conclusions: In decompensated cardiomyopathic hamsters, a decline in BTCR amplitude was associated with progression of heart failure and cardiac decompensation. Variation in BTCR warrants further investigation because of its potential implications for the diagnosis and treatment of cardiovascular disorders. (Source: Journal of Cardiac Failure)

Uncovering Interim Clinical Events at the Time of Clinical Encounter by Reviewing Intrathoracic Impedance Threshold Crossings

Journal of Cardiac Failure — Fri, 19 Aug 2011 04:00:00 +0100

Conclusions: Our data demonstrated that reviewing device-derived intrathoracic impedance trends at the time of clinical encounter may help uncover self-reporting of potential clinically relevant events. (Source: Journal of Cardiac Failure)

Assessing Health Literacy in Heart Failure Patients

Journal of Cardiac Failure — Fri, 19 Aug 2011 04:00:00 +0100

Conclusion: Patients with HF may be inaccurately categorized as having low or marginal health literacy when the S-TOFHLA time limits are enforced. New ways to assess health literacy in older adults are needed. (Source: Journal of Cardiac Failure)

Nurse-Enhanced Memory Intervention in Heart Failure: The MEMOIR Study

Journal of Cardiac Failure — Fri, 19 Aug 2011 04:00:00 +0100

Conclusions: To our knowledge, this was the first test of Brain Fitness in HF. Although it was a preliminary study with limitations, results support the need for a larger randomized controlled trial to determine whether the memory loss of HF is amenable to plasticity-based interventions. (Source: Journal of Cardiac Failure)

Activity With Ambulation Attenuates Diuretic Responsiveness in Chronic Heart Failure

Journal of Cardiac Failure — Fri, 19 Aug 2011 04:00:00 +0100

Abstract: Introduction: We hypothesized that discharged heart failure (HF) patients could develop clinical congestion despite adhering to prescribed diuretics, because ambulation attenuates diuretic and natriuretic responsiveness.Methods: We studied 9 patients aged 57 ± 13 (mean ± SD) years with New York Heart Association functional class II-III symptoms and ejection fraction (Source: Journal of Cardiac Failure)

Where Have All the Clinical Trials Gone?

Journal of Cardiac Failure — Sun, 07 Aug 2011 23:00:00 +0100

The bedrock of progress in the field of heart failure, which has been substantial since the 1980s, has been the randomized controlled trial. The model we have generally followed has gone something like this: an observation is made in a small group of patients, a concept emerges, a hypothesis is constructed, a protocol is designed to test the hypothesis, financial support is secured, and a randomized clinical trial is executed, analyzed, and published. Sample sizes have increased substantially over the years, statistical analysis has become more sophisticated, and, importantly, costs have become unsustainable. This model, which was used by Dr. E. D. Freis in the mid-1950s to study antihypertensive therapy, has served us well for many years. However, it is increasingly clear that this model ...

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Journal of Cardiac Failure — Sun, 31 Jul 2011 23:00:00 +0100

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Journal of Cardiac Failure — Sun, 31 Jul 2011 23:00:00 +0100

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Journal of Cardiac Failure — Sun, 31 Jul 2011 23:00:00 +0100

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Journal of Cardiac Failure — Sun, 31 Jul 2011 23:00:00 +0100

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Journal of Cardiac Failure — Sun, 31 Jul 2011 23:00:00 +0100

The article “Accuracy of Doppler Echocardiography to Estimate Key Hemodynamic Variables in Subjects With Normal Left Ventricular Ejection Fraction,” by Maeder et al (J Card Fail 2011;17:405-12), was published with an error in Table 1. The authors incorrectly stated the body mass index in the PAH group as 46.8+/-17.9. The correct body mass index in the PAH group is 27.9 +/- 8.6 kg/m2. This error has been corrected in revised Table 1, shown below. (Source: Journal of Cardiac Failure)

Use of Biomarkers to “Guide” Care in Chronic Heart Failure: What Have We Learned (So Far)?

Journal of Cardiac Failure — Sun, 31 Jul 2011 23:00:00 +0100

The active clinician recognizes the challenges of well managing the patient suffering from chronic heart failure (HF). Numerous impediments exist to the achievement of optimal care for such patients, including and especially the attainment of a medication program that aims to simultaneously minimize both symptoms and potential side effects, while achieving goal doses of applied therapies. Frequent office visits along with constant evaluation and management is most often needed to optimize care; this more often than not requires great skill to recognize opportunities to titrate therapies and the acumen to implement such changes. (Source: Journal of Cardiac Failure)

Right Ventricular Energetics in Patients With Hypertrophic Cardiomyopathy and the Effect of Alcohol Septal Ablation

Journal of Cardiac Failure — Tue, 26 Jul 2011 04:00:00 +0100

Conclusions: In HCM patients, RV oxygen consumption is increased in relation to the LV. ASA reduces RV oxygen consumption in HCM patients with LVOT obstruction, suggesting that increased LV loading conditions and diastolic dysfunction play a predominant role in augmenting RV workload in these patients. (Source: Journal of Cardiac Failure)

Mortality Reduction of Cardiac Resynchronization and Implantable Cardioverter-Defibrillator Therapy in Heart Failure: An Updated Meta-Analysis. Does Recent Evidence Change the Standard of Care?

Journal of Cardiac Failure — Mon, 25 Jul 2011 04:00:00 +0100

Conclusion: Combined CRT and ICD therapy reduces overall mortality in HF patients when compared with ICD alone. (Source: Journal of Cardiac Failure)

Functional Mitral Regurgitation: A Link to Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction

Journal of Cardiac Failure — Mon, 25 Jul 2011 04:00:00 +0100

Conclusions: Pulmonary hypertension appears to be linked to the presence of functional MR in HFpEF patients. (Source: Journal of Cardiac Failure)

The Effect of Progressive, Reinforcing Telephone Education and Counseling Versus Brief Educational Intervention on Knowledge, Self-Care Behaviors and Heart Failure Symptoms

Journal of Cardiac Failure — Mon, 25 Jul 2011 04:00:00 +0100

Abstract: Background: The optimal strategy for promoting self-care for heart failure (HF) is unclear.Methods and Results: We conducted a randomized trial to determine whether a “teach to goal” (TTG) educational and behavioral support program provided incremental benefits to a brief (1 hour) educational intervention (BEI) for knowledge, self-care behaviors, and HF-related quality of life (HFQOL). The TTG program taught use of adjusted-dose diuretics and then reinforced learning goals and behaviors with 5 to 8 telephone counseling sessions over 1 month. Participants' (n = 605) mean age was 61 years; 37% had marginal or inadequate literacy; 69% had ejection fraction (Source: Journal of Cardiac Failure)

Noninvasive Ventilation in Acute Cardiogenic Pulmonary Edema: A Meta-Analysis of Randomized Controlled Trials

Journal of Cardiac Failure — Mon, 11 Jul 2011 04:00:00 +0100

Conclusions: Our findings suggest that among ACPE patients, NIV delivered through either NIPPV or CPAP reduced mortality. (Source: Journal of Cardiac Failure)

Serum Pregnancy-Associated Plasma Protein A in Patients With Heart Failure

Journal of Cardiac Failure — Mon, 11 Jul 2011 04:00:00 +0100

Conclusions: Serum PAPP-A levels were related to the severity of HF and associated with a high risk for adverse cardiac events in HF patients, suggesting that PAPP-A might be involved in the pathogenesis of HF. (Source: Journal of Cardiac Failure)

Inhaled Iloprost for Patients With Precapillary Pulmonary Hypertension and Right-Side Heart Failure

Journal of Cardiac Failure — Mon, 11 Jul 2011 04:00:00 +0100

Conclusion: Blood pressure-guided hourly inhalation of iloprost may offer a safe and effective strategy for the treatment of PH patients with RHF. (Source: Journal of Cardiac Failure)

Carvedilol for the Treatment of Benign Prostatic Hypertrophy in Patients With Heart Failure?

Journal of Cardiac Failure — Fri, 24 Jun 2011 04:00:00 +0100

We present a case where carvedilol was replaced with bisoprolol resulting in acute urinary retention. When carvediolol was reinstituted, the patient's symptoms of BPH resolved. Benign prostatic hypertrophy was later diagnosed by digital rectal exam. Six month after reinstituting the carvediolol, the patient remains free of his BPH symptoms. This case suggests that carvedilol may be considered for the management of HF with systolic dysfunction in patients with concomitant BPH thus eliminating the need for an α1-adrenergic blockers. (Source: Journal of Cardiac Failure)

Short-Term Variability of Heart Rate Turbulence in Chronic Heart Failure

Journal of Cardiac Failure — Thu, 23 Jun 2011 23:00:00 +0100

Conclusions: In this population, 7DH significantly increased the percentage of patients with calculable HRT parameters. The short-term variability of the quantitative HRT values was good, but when patients were categorized into the established HRT subgroups, the concordance was suboptimal. (Source: Journal of Cardiac Failure)

Impact of Medication Nonadherence on Hospitalizations and Mortality in Heart Failure

Journal of Cardiac Failure — Thu, 23 Jun 2011 23:00:00 +0100

Abstract: Background: Limited literature exists on the association between medication adherence and outcomes among patients with heart failure.Methods and Results: We conducted a retrospective longitudinal cohort study of 557 patients with heart failure with reduced ejection fraction (HFrEF) (defined by EF (Source: Journal of Cardiac Failure)

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Journal of Cardiac Failure — Thu, 23 Jun 2011 16:41:43 +0100

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Journal of Cardiac Failure — Thu, 23 Jun 2011 16:41:43 +0100

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Journal of Cardiac Failure — Thu, 23 Jun 2011 16:41:43 +0100

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Journal of Cardiac Failure — Thu, 23 Jun 2011 16:41:43 +0100

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Subgroup Analysis of a Randomized Controlled Trial Evaluating the Safety and Efficacy of Cardiac Contractility Modulation in Advanced Heart Failure

Journal of Cardiac Failure — Wed, 22 Jun 2011 23:00:00 +0100

Conclusions: The results of this retrospective hypothesis-generating analysis indicate that CCM significantly improves objective parameters of exercise tolerance in a subgroup of patients characterized by normal QRS duration, NYHA functional class III symptoms, and EF >25%. (Source: Journal of Cardiac Failure)

Isolated Noncompaction of the Left Ventricular Myocardium in Adults: A Systematic Overview

Journal of Cardiac Failure — Sun, 19 Jun 2011 23:00:00 +0100

Conclusion: LVNC is an increasingly recognized cardiomyopathy diagnosed by echocardiography and is associated with familial tendencies, arrhythmias, thromboembolism, advanced heart failure, and death. (Source: Journal of Cardiac Failure)

Effects of Sertraline on Circulating Markers of Oxidative Stress in Depressed Patients With Chronic Heart Failure: A Pilot Study

Journal of Cardiac Failure — Sun, 19 Jun 2011 23:00:00 +0100

Conclusions: Increased oxidative stress may play a critical role in the pathophysiology of depression in CHF. Treatment with sertraline improves depressive symptoms and reduces plasma markers of oxidative stress in depressed CHF patients. (Source: Journal of Cardiac Failure)

Noninvasive Monitoring of Left Ventricular End-Diastolic Pressure Reduces Rehospitalization Rates in Patients Hospitalized for Heart Failure: A Randomized Controlled Trial

Journal of Cardiac Failure — Sun, 19 Jun 2011 23:00:00 +0100

Abstract: Background: In patients admitted for heart failure (HF), unrecognized elevation of left ventricular end-diastolic pressure (LVEDP) at the time of discharge may have a role in the high rehospitalization rate for HF on follow-up.Methods and Results: In a small, prospective study (n = 50), patients admitted for HF were randomized to management guided by daily noninvasive estimated LVEDP monitoring (Group I, open) to a target LVEDP of (Source: Journal of Cardiac Failure)

Alcoholic Cardiomyopathy: A Review

Journal of Cardiac Failure — Fri, 17 Jun 2011 04:00:00 +0100

Abstract: Alcohol abuse can cause cardiomyopathy indistinguishable from other types of dilated nonischemic cardiomyopathy. Most heavy drinkers remain asymptomatic in the earlier stages of disease progression, and many never develop the familiar clinical manifestations that typify heart failure. We review the current thinking on the pathophysiology, clinical characteristics, and treatments available for alcoholic cardiomyopathy. The relationship of alcohol to heart disease is complicated by the fact that in moderation, alcohol has been shown to afford a certain degree of protection against cardiovascular disease. (Source: Journal of Cardiac Failure)

Non–Symptom-Related Factors Contributing to Delay in Seeking Medical Care by Patients With Heart Failure: A Narrative Review

Journal of Cardiac Failure — Thu, 16 Jun 2011 23:00:00 +0100

Conclusions: Although this review identified several non–symptom-related factors that may be implicated in care-seeking delay, health care professionals should be vigilant in identifying all high-risk individuals and educating them about warning signs of HF. Moreover, access to outpatient chronic disease management programs that may have potential to reduce care-seeking delay behavior should be explored. (Source: Journal of Cardiac Failure)

Association Between Prehospital Time Interval and Short-Term Outcome in Acute Heart Failure Patients

Journal of Cardiac Failure — Thu, 16 Jun 2011 23:00:00 +0100

Conclusions: Transportation time correlated with risk-adjusted mortality, and steps should be taken to reduce the EMS transfer time to improve the outcome in AHF patients. (Source: Journal of Cardiac Failure)

Comparative Long Term Effects of Nebivolol and Carvedilol in Hypertensive Heart Failure Patients

Journal of Cardiac Failure — Thu, 16 Jun 2011 23:00:00 +0100

Abstract: Background: Beta-blockers improve left ventricular (LV) systolic function and prognosis in patients with chronic heart failure (CHF), but their different pleiotropic properties may influence their cardiovascular effects. This open-label study compared the effects of long-term treatment with nebivolol versus carvedilol on LV ejection fraction (LVEF), in hypertensive CHF patients. Secondary end points were to assess the effect of the 2 beta-blockers on exercise capacity and clinical outcome.Methods and Results: A total of 160 hypertensive CHF patients, with LVEF (Source: Journal of Cardiac Failure)

A Pharmacokinetic Analysis of Molecular Cardiac Surgery With Recirculation Mediated Delivery of βARKct Gene Therapy: Developing a Quantitative Definition of the Therapeutic Window

Journal of Cardiac Failure — Sun, 12 Jun 2011 23:00:00 +0100

Conclusion: MCARD may offer a viable method to establish a relationship between vector exposure and in vivo transduction. Using this methodology, it may be possible to address a critical need for establishing an effective therapeutic window. (Source: Journal of Cardiac Failure)

Risk Factors for Onset of Disability Among Older Persons Newly Diagnosed With Heart Failure: The Cardiovascular Health Study

Journal of Cardiac Failure — Sun, 05 Jun 2011 23:00:00 +0100

Abstract: Background: As the heart failure population continues to age, disability is becoming an increasingly important issue. Our objective was to identify risk factors for the onset of disability in activities of daily living among older persons with heart failure.Methods: The study population included participants with newly diagnosed heart failure from the Cardiovascular Health Study, a longitudinal study of community-living, older persons. Data were collected through annual examinations. Cox regression modeling was used to examine associations between time-dependent predictors and onset of disability.Results: Of 461 participants newly diagnosed with heart failure (mean age 78.7 [SD 5.89]), 23% subsequently developed disability. The first year after heart failure diagnosis was the per...

Depressive Symptom Trajectory Predicts 1-Year Health-Related Quality of Life in Patients With Heart Failure

Journal of Cardiac Failure — Sun, 05 Jun 2011 23:00:00 +0100

Conclusions: We found the trajectory of depressive symptoms predicts future HRQOL. Research is needed to determine whether interventions targeting depressive symptoms improve HRQOL in patients with HF. (Source: Journal of Cardiac Failure)

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Journal of Cardiac Failure — Mon, 30 May 2011 15:27:59 +0100

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Journal of Cardiac Failure — Mon, 30 May 2011 15:27:59 +0100

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Journal of Cardiac Failure — Mon, 30 May 2011 15:27:59 +0100

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Journal of Cardiac Failure — Mon, 30 May 2011 15:27:59 +0100

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The Year in Quality of Care in Heart Failure

Journal of Cardiac Failure — Mon, 30 May 2011 15:27:56 +0100

Heart failure (HF) affects over 5.5 million Americans, and more than 650,000 incident cases are diagnosed each year. Moreover, the prevalence and incidence of HF are increasing, in large part owing to the aging of the population. Indeed, HF is the leading cause of hospital admissions and readmissions in the Medicare age group, and it is associated with a poor prognosis: 1-year mortality rates of 20%–30% and 5-year mortality rates of 50%–60%. In addition, HF is a major source of disability and impaired quality of life. Conversely, numerous behavioral, pharmacologic, and procedural interventions have been shown to alleviate symptoms, improve quality of life, and reduce mortality in HF patients. Despite these advancements, translation of existing evidence into routine care of HF patients ...

In Memoriam

Journal of Cardiac Failure — Mon, 30 May 2011 15:27:55 +0100

Ralph Shabetai, MD, FRCP, FACC passed away on October 15, 2010, at the age of 85 years. In a career that spanned more than half a century, he was a preeminent expert in pericardial diseases, a master clinician, an expert in heart failure and exercise physiology, and a wonderful mentor for generations of clinicians, researchers, and academicians. Ralph is survived by Estelle, his beloved wife of 58 years, their children and grandchildren, and many, many loyal and appreciative friends, colleagues, and patients. (Source: Journal of Cardiac Failure)

Clinical Utility of Three B-Type Natriuretic Peptide Assays for the Initial Diagnostic Assessment of New Slow-Onset Heart Failure

Journal of Cardiac Failure — Sun, 29 May 2011 23:00:00 +0100

Conclusion: In practice, a valid diagnosis in patients suspected of slow-onset heart failure remains elusive for many in the absence of echocardiographic imaging. (Source: Journal of Cardiac Failure)

Relevance of Water Gymnastics in Rehabilitation Programs in Patients With Chronic Heart Failure or Coronary Artery Disease With Normal Left Ventricular Function

Journal of Cardiac Failure — Sun, 29 May 2011 23:00:00 +0100

Conclusions: Altogether, both land and water-based programs were well tolerated and triggered improvements in cardiorespiratory function. (Source: Journal of Cardiac Failure)

Peripheral Adaptation Mechanisms in Physical Training and Cardiac Rehabilitation: The Case of a Patient Supported by a Cardiowest Total Artificial Heart

Journal of Cardiac Failure — Sun, 29 May 2011 23:00:00 +0100

Conclusion: This unique situation of a patient with a TAH, and therefore a fixed peak cardiac output, allows us to isolate training-induced changes in the periphery, that suggest greater oxygen extraction and more efficient metabolic gas kinetics during the exercise and recovery phases. (Source: Journal of Cardiac Failure)

Factors Associated With Patient Delay in Seeking Care After Worsening Symptoms in Heart Failure Patients

Journal of Cardiac Failure — Sun, 29 May 2011 23:00:00 +0100

Abstract: Background: To receive optimal treatment and care, it is essential that heart failure (HF) patients react adequately to worsening symptoms and contact a health care provider early. This specific “patient delay” is an important part of the total delay time. The purpose of this study was to assess patient delay and its associated variables in HF patients.Methods and Results: In this cross-sectional study, data of 911 hospitalized HF patients from 17 Dutch hospitals (mean age 71 ± 12 years; 62% male; left ventricular ejection fraction 34 ± 15%) were analyzed. During the index hospitalization, patient delay and HF symptoms were assessed by interview. Patients completed questionnaires on depressive symptoms, knowledge and compliance. Clinical and demographic data were collected ...

Predictors of Hospital Length of Stay in Heart Failure: Findings from Get With the Guidelines

Journal of Cardiac Failure — Sun, 29 May 2011 23:00:00 +0100

Conclusions: Based on admission vital signs and BNP levels, patients with longer LOS have more comorbidities and a higher disease severity. The ability to risk stratify for LOS based on patient admission and hospital characteristics is limited. (Source: Journal of Cardiac Failure)

Results of the Randomized Aldosterone Antagonism in Heart Failure With Preserved Ejection Fraction Trial (RAAM-PEF)

Journal of Cardiac Failure — Sun, 29 May 2011 23:00:00 +0100

Conclusions: Although eplerenone was not associated with an improvement in exercise capacity compared to placebo, it was associated with significant reduction in markers of collagen turnover and improvement in diastolic function. Whether these favorable effects will translate into morbidity and mortality benefit in HFpEF remains to be determined. (Source: Journal of Cardiac Failure)

Determinants of Red Cell Distribution Width (RDW) in Cardiorenal Patients: RDW is Not Related to Erythropoietin Resistance

Journal of Cardiac Failure — Sun, 29 May 2011 23:00:00 +0100

Conclusions: EPO resistance was not associated with RDW. RDW was associated with functional iron availability, erythropoietic activity, and interleukin-6 in anemic patients with CHF and CKD. (Source: Journal of Cardiac Failure)

The STARBRITE Trial: A Randomized, Pilot Study of B-Type Natriuretic Peptide–Guided Therapy in Patients With Advanced Heart Failure

Journal of Cardiac Failure — Sun, 29 May 2011 23:00:00 +0100

Conclusions: BNP strategy was not associated with more days alive and not hospitalized, but the strategy appeared to be safe and was associated with increased use of evidence-based medications. (Source: Journal of Cardiac Failure)

Heart Failure Patients Monitored With Telemedicine: Patient Satisfaction, a Review of the Literature

Journal of Cardiac Failure — Sun, 08 May 2011 23:00:00 +0100

Conclusions: Measurement of patient satisfaction is still underexposed in telemedicine research and the measurement of patient satisfaction with telemedicine underappreciated with poorly constructed questionnaires. (Source: Journal of Cardiac Failure)

Prevention of Chemotherapy-Induced Left Ventricular Dysfunction With Enalapril and Carvedilol: Rationale and Design of the OVERCOME Trial

Journal of Cardiac Failure — Sun, 08 May 2011 23:00:00 +0100

Conclusions: The OVERCOME study will be the first clinical trial to test the preventive efficacy on LVD of combined treatment with enalapril and carvedilol administered to patients with hematologic malignancies submitted to current treatment with intensive chemotherapy. (Source: Journal of Cardiac Failure)

The Impact of Extra Cardiac Comorbidities on Pressure Volume Relations in Heart Failure and Preserved Ejection Fraction

Journal of Cardiac Failure — Sun, 08 May 2011 23:00:00 +0100

Conclusions: The presence of comorbid conditions is associated with altered pressure-volume relations and enhanced pump function in subjects with HFPEF, supporting an important role for extracardiac comorbidities in the pathophysiology of patients with this condition. (Source: Journal of Cardiac Failure)

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Journal of Cardiac Failure — Sat, 30 Apr 2011 23:00:00 +0100

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Journal of Cardiac Failure — Sat, 30 Apr 2011 23:00:00 +0100

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Journal of Cardiac Failure — Sat, 30 Apr 2011 23:00:00 +0100

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Journal of Cardiac Failure — Sat, 30 Apr 2011 23:00:00 +0100

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Weighing in on Obesity and the Obesity Paradox in Heart Failure

Journal of Cardiac Failure — Sat, 30 Apr 2011 23:00:00 +0100

There is considerable evidence that obesity has been increasing in epidemic proportions in adults and children in the United States, and this epidemic is likely spreading to much of the Westernized world. Clearly, obesity has adverse effects on most of the major cardiovascular (CV) disease risk factors, and is associated with increased risk of most CV diseases, including coronary heart disease (CHD), hypertension (HTN), and atrial fibrillation (AF) as well as heart failure (HF). Although most of the evidence regarding obesity and increased CV risk is based on body mass index (BMI) criteria, which is used in most of the major epidemiological studies, this has also been demonstrated with abdominal or central obesity, including the use of waist circumference (WC). (Source: Journal of Cardiac ...

ACCF/AHA/HFSA 2011 Survey Results: Current Staffing Profile of Heart Failure Programs, Including Programs That Perform Heart Transplant and Mechanical Circulatory Support Device Implantation

Journal of Cardiac Failure — Sat, 30 Apr 2011 23:00:00 +0100

Conclusions: The HF patient population is growing in number in the United States and internationally, and the clinicians who provide the highly skilled and time-consuming care to this population are under intense scrutiny as a result of focused quality improvement initiatives and reduced financial resources. Staffing guidelines should be developed to ensure that an adequate number of qualified professionals are hired for a given practice volume. These survey results are an initial step in developing such standards. (Source: Journal of Cardiac Failure)

Outcomes for Women and Men Who Attend a Heart Failure Clinic: Results of a 12-Month Longitudinal Study

Journal of Cardiac Failure — Thu, 28 Apr 2011 23:00:00 +0100

Conclusions: Both men and women with HF who attend specialized HF clinics improved, including those with more severe disease. (Source: Journal of Cardiac Failure)

Heart Failure With Recovered Ejection Fraction: A Distinct Clinical Entity

Journal of Cardiac Failure — Thu, 28 Apr 2011 23:00:00 +0100

Abstract: Background: A subset of patients with heart failure (HF) and preserved left ventricular ejection fraction (EF) previously had EF (Source: Journal of Cardiac Failure)

Human Hepatocyte Growth Factor (VM202) Gene Therapy via Transendocardial Injection in a Pig Model of Chronic Myocardial Ischemia

Journal of Cardiac Failure — Sun, 24 Apr 2011 23:00:00 +0100

Conclusions: Transendocardial delivery of VM202 was safe and may help to preserve microcirculatory perfusion and improve wall motion. (Source: Journal of Cardiac Failure)

β-Adrenergic Receptor Stimulation and Activation of Protein Kinase A Protect Against α1-Adrenergic–Mediated Phosphorylation of Protein Kinase D and Histone Deacetylase 5

Journal of Cardiac Failure — Sun, 24 Apr 2011 23:00:00 +0100

Conclusions: These data indicate that the PKA-dependent arm of β-AR signaling can be antihypertrophic and presumably beneficial, through dephosphorylation of PKD and HDAC5 and reduction of hypertrophic fetal isoform gene expression. (Source: Journal of Cardiac Failure)

Effects of Interval Cycle Training With or Without Strength Training on Vascular Reactivity in Heart Failure Patients

Journal of Cardiac Failure — Sun, 24 Apr 2011 23:00:00 +0100

Conclusions: A combined high-intensity, interval cycle exercise with strength training induces a greater beneficial effect on vascular reactivity rather than interval exercise training alone in CHF patients. (Source: Journal of Cardiac Failure)

Gamma-Glutamyltransferase Rather Than Total Bilirubin Predicts Outcome in Chronic Heart Failure

Journal of Cardiac Failure — Sun, 24 Apr 2011 23:00:00 +0100

This study sought to compare these novel cardiovascular risk markers in CHF.Methods and Results: We evaluated 1,087 ambulatory patients from our heart failure program. Long-term follow-up was available in 1,056 patients. The combined end point was defined as death of any cause or heart transplantation. Prevalence of elevated GGT was 43% in men and 48% in women, that of T-Bil 17% and 8%, respectively. Both variables were significantly correlated with severity of heart failure. GGT and T-Bil were associated with transplant-free survival in bivariate analysis (P values (Source: Journal of Cardiac Failure)

Improved Algorithm to Detect Fluid Accumulation via Intrathoracic Impedance Monitoring in Heart Failure Patients With Implantable Devices

Journal of Cardiac Failure — Sun, 24 Apr 2011 23:00:00 +0100

Conclusions: A modified intrathoracic impedance based fluid detection algorithm lowered the number of unexplained FI threshold crossings and identified patients at significantly increased immediate risk of worsening HF. (Source: Journal of Cardiac Failure)

Mismatch of Right- and Left-Sided Filling Pressures in Chronic Heart Failure

Journal of Cardiac Failure — Sun, 24 Apr 2011 23:00:00 +0100

Abstract: Background: In patients with advanced heart failure (HF), elevated jugular venous pressure (JVP) is the most reliable sign of elevated left-sided filling pressures. However, discordance between right- and left-sided filling pressures (R-L mismatch) could lead to inadequate or excessive therapy guided by JVP. We determined the prevalence of R-L mismatch in the current era and investigated whether mismatch might be identified from clinical information.Methods and Results: Right-sided heart catheterization was performed in 537 consecutive patients hospitalized with advanced HF during complete transplantation evaluation. Patients with high filling pressures were categorized as matched (right atrial pressure (RAP) ≥10 mm Hg and pulmonary wedge pressure (PCWP) ≥22 mm Hg), high-R m...

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Erratum

Indications for Cardiac Resynchronization Therapy: 2011 Update From the Heart Failure Society of America Guideline Committee

The Heart Failure Society of America in 2020: A Vision for the Future

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Echocardiographic Evaluation of Left Ventricular Structure and Function: New Modalities and Potential Applications in Clinical Trials

Survival Benefit of Implantable Cardioverter-Defibrillators in Left Ventricular Assist Device–Supported Heart Failure Patients

Impact of Ventricular Dyssynchrony on Postexercise Accommodation of Systolic Myocardial Motion in Hypertensive Patients With Heart Failure and a Normal Ejection Fraction: A Tissue-Doppler Echocardiography Study

Change in Intrathoracic Impedance Measures During Acute Decompensated Heart Failure Admission: Results From the Diagnostic Data for Discharge in Heart Failure Patients (3D-HF) Pilot Study

On Being Smart

Cardiac Resynchronization Therapy in the Real World: Comparison With the COMPANION Study

Progressive Rise in Red Cell Distribution Width Is Associated With Disease Progression in Ambulatory Patients With Chronic Heart Failure

Coincidence of Apical Ballooning Syndrome (Tako-Tsubo/Stress Cardiomyopathy) and Posterior Reversible Encephalopathy Syndrome: Potential Common Substrate and Pathophysiology?

Trastuzumab Adjuvant Chemotherapy and Cardiotoxicity in Real-World Women With Breast Cancer

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Acknowledgment of Reviewers

The Cardiorenal Syndrome: Should Change Make Us Uncomfortable?

Controlling the Flood Gates: Vaptans, Furosemide and the Quest for a Renal Protective Diuresis

High-Intensity Interval Exercise in Chronic Heart Failure: Protocol Optimization

Myocardial G Protein Receptor–Coupled Kinase Expression Correlates With Functional Parameters and Clinical Severity in Advanced Heart Failure

Comorbidity Drives Mortality in Newly Diagnosed Heart Failure: A Study Among Geriatric Outpatients

Long-Term Prognostic Value of CA 125 Serum Levels in Mild to Moderate Heart Failure Patients

The “Obesity Paradox”: Does It Persist Among Israeli Patients With Decompensated Heart Failure? A Subanalysis of the Heart Failure Survey in Israel (HFSIS)

Comorbid Diabetes and End-of-Life Expenditures Among Medicare Beneficiaries With Heart Failure

Relationship Between Diastolic Function and Heart Rate Recovery After Symptom-Limited Exercise

Myocardial Recovery in Peripartum Cardiomyopathy: Prospective Comparison With Recent Onset Cardiomyopathy in Men and Nonperipartum Women

Cognitive Therapy Improves Three-Month Outcomes in Hospitalized Patients With Heart Failure

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Intrathoracic Impedance Monitoring, Audible Patient Alerts, and Outcome in Patients With Heart Failure

Surgical Treatment of Ischemic Heart Failure Trial

Clinical Outcomes at 180 days in the ASCEND-HF Trial: Double-Blind, Placebo-Controlled, Multicenter Acute Study of Clinical Effectiveness of Nesiritide in Subjects With Decompensated Heart Failure

Treatment of acute decompensated heart failure with the soluble guanylate cyclase activator cinaciguat: The COMPOSE program – three randomized, controlled, phase IIb studies

The Evidence Base for Diuretic Therapy

Flexible Diuretic Titration in Chronic Heart Failure: Where Is the Evidence?

Iron Deficiency Predicts Impaired Exercise Capacity in Patients With Systolic Chronic Heart Failure

Hyponatremia and Long-Term Outcomes in Chronic Heart Failure—An Observational Study From the Duke Databank for Cardiovascular Diseases

Characteristics and Outcomes of Peripartum Versus Nonperipartum Cardiomyopathy in Women Using a Wearable Cardiac Defibrillator

Effect of a Medication-Taking Behavior Feedback Theory–Based Intervention on Outcomes in Patients With Heart Failure

Angiotensin-Converting Enzyme Inhibition Promotes Coronary Angiogenesis in the Failing Heart of Dahl Salt-Sensitive Hypertensive Rats

Patient Characteristics From a Regional Multicenter Database of Acute Decompensated Heart Failure in Asia Pacific (ADHERE International–Asia Pacific)

Heart Failure Is a Risk Factor for Incident Driving Cessation Among Community-Dwelling Older Adults: Findings From a Prospective Population Study

Renal Effects of Conivaptan, Furosemide, and the Combination in Patients With Chronic Heart Failure

Right Ventricular Dysfunction Compromises Accuracy of Echocardiographic Diagnosis of Pulmonary Hypertension in Heart Failure

Dynamics in Insulin Resistance and Plasma Levels of Adipokines in Patients With Acute Decompensated and Chronic Stable Heart Failure

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Found in Translation

Clinical Characteristics and Outcomes of Patients With Improvement in Renal Function During the Treatment of Decompensated Heart Failure

Doxercalciferol, a Pro-hormone of Vitamin D, Prevents the Development of Cardiac Hypertrophy in Rats

Myocardial Deformation Analysis in Chagas Heart Disease With the Use of Speckle Tracking Echocardiography

Systemic Oxidative Stress and Endothelial Dysfunction is Associated With an Attenuated Acute Vascular Response to Inhaled Prostanoid in Pulmonary Artery Hypertension Patients

A Multicenter, Randomized, Double-blind, Placebo-controlled Study of Tolvaptan Monotherapy Compared to Furosemide and the Combination of Tolvaptan and Furosemide in Patients With Heart Failure and Systolic Dysfunction

Catheter Ablation for Atrial Fibrillation in Patients With Left Ventricular Systolic Dysfunction. A Systematic Review and Meta-Analysis

Left Ventricular Geometry, Global Function, and Dyssynchrony in Infants and Children With Pompe Cardiomyopathy Undergoing Enzyme Replacement Therapy

A Cellular MicroRNA, let-7i, Is a Novel Biomarker for Clinical Outcome in Patients With Dilated Cardiomyopathy

Low Systolic Blood Pressure at Admission Predicts Long-Term Mortality in Heart Failure With Preserved Ejection Fraction

Clinical Correlates of Hemoconcentration During Hospitalization for Acute Decompensated Heart Failure

Hemodynamic Effects of Exercise Training in Heart Failure

Statins Do Not Significantly Affect Muscle Sympathetic Nerve Activity in Humans With Nonischemic Heart Failure: A Double-Blind Placebo-Controlled Trial

Molecular Signatures of End-Stage Heart Failure

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