Journal of Complementary and Integrative Medicine via MedWorm.com

A New Generation of Complementary Medicine Users?

Journal of Complementary and Integrative Medicine — Fri, 20 Jan 2012 20:25:57 +0100

Conclusions: Reasons of effect provided by participants were that they provided a genuine effect; a general effect; or a placebo effect. (Source: Journal of Complementary and Integrative Medicine)

Anti-Inflammatory Effects of Shea Butter through Inhibition of Inos, Cox-2, and Cytokines via the Nf-Kb Pathway in Lps-Activated J774 Macrophage Cells

Journal of Complementary and Integrative Medicine — Thu, 12 Jan 2012 18:19:40 +0100

In this study we explored the anti-inflammatory activities of the methanolic extract of shea butter (SBE) using lipopolysaccharide (LPS)-induced murine macrophage cell line J774. It was observed that SBE significantly reduced the levels of LPS-induced nitric oxide, Tumor necrosis factor-α (TNF-α), interleukins, 1β (IL-1β), and -12 (IL-12) in the culture supernatants in a dose dependent manner. Expression of pro-inflammatory enzymes, inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) were also inhibited by SBE. These anti-inflammatory effects were due to an inhibitory action of SBE on LPS-induced iNOS, COX-2, TNF-α, IL-1β, and IL-12 mRNA expressions. Moreover, SBE efficiently suppressed IκBα phosphorylation and NF-κB nuclear translocation induced by LPS. These fin...

Contractile Effect of Radish and Betel Nut Extracts on Rabbit Gallbladder

Journal of Complementary and Integrative Medicine — Wed, 11 Jan 2012 19:34:43 +0100

This study justifies the traditional use of radish and betel nut in different gastrointestinal disorders. (Source: Journal of Complementary and Integrative Medicine)

H. Spinosa T. Anders Ameliorates Diabetic Neuropathy in Wistar Albino Rats

Journal of Complementary and Integrative Medicine — Tue, 10 Jan 2012 17:49:25 +0100

Diabetic neuropathic pain, an important microvascular complication in diabetes, is recognised as one of the most difficult types of pain to treat. The development of tolerance, inadequate relief, and potential toxicity of classical antinociceptives warrant the investigation of the newer agents to relieve this pain. Reactive oxygen/nitrogen species, increased oxidative stress, cytokines, and apoptosis are implicated in the pathogenesis of diabetic neuropathy. The aim of the present study was to explore the effect of methanolic extract of aerial parts of H. spinosa (HSME) on alloxan induced diabetic neuropathy in Wistar rats. Diabetic rats developed neuropathy after the third week of diabetes induction. Chronic treatment with HSME (250, 500, and 750 mg/kg body weight; p.o.) for 6 weeks start...

Protective Effects of Capparis sepiaria Root Extracts against Acetaminophen-Induced Hepatotoxicity in Wistar Rats

Journal of Complementary and Integrative Medicine — Mon, 09 Jan 2012 17:36:11 +0100

In this study extracts of the root of C. sepiaria were evaluated for their hepatoprotective potential on acetaminophen-induced hepatotoxicity in albino Wistar rats. The extent of hepatoprotection was evaluated by estimating the serum levels of hepatic transaminases (SGPT and SGOT), alkaline phosphatase (ALP), total protein (TP), and bilirubin (total and direct). Aqueous and ethanol extracts of C. sepiaria significantly reduced the increased liver weight as well as serum levels of SGPT, SGOT, ALP, and bilirubin, and normalized the reduced serum protein levels in the treated rats. These observations were supported by the results of histopathology studies as well. The extracts were also subjected to preliminary organic analysis and chromatographic studies including HPTLC finger print studies....

Effects of Panax Notoginseng (Chinese Ginseng) and Acute Exercise on Postprandial Glycemia in Non-diabetic Adults

Journal of Complementary and Integrative Medicine — Wed, 04 Jan 2012 17:10:30 +0100

The purpose of this study is to determine whether Panax Notoginseng (PNG) taken for 3 days and one 30-min cycling exercise can reduce postprandial hyperglycemia after ingesting a 75-mg oral glucose solution (OGTT) in untrained non-diabetic men, age 20-45 years. We randomly assigned 52 men to: 1) ginseng (G) + exercise (G+Ex, n=14), 2) ginseng (G, n=13), 3) placebo (C) + exercise (C+Ex, n=12), and 4) placebo control groups (C, n=13). The G and C groups took a daily 3g dose of PNG and cornstarch-placebo supplement for 3 days, respectively. The exercise groups also performed a 30-min cycling exercise on day 3 prior to OGTT. The daily 3g-dose of PNG supplementation significantly lowered postprandial plasma glucose (PG) concentration at 30 min post-OGTT in the G group, compared with C (mean Δ�...

Pharmacological Study of the Effect of Licorice Alone and in Combination with Diclofenac Sodium on Hepatotoxicity-induced Experimentally in Rats.

Journal of Complementary and Integrative Medicine — Fri, 16 Dec 2011 23:59:25 +0100

The protective effect of licorice and diclofenac sodium in doses of 50 mg/kg bwt. and 5 mg/kg bwt. respectively against liver toxicity induced by CCl4 (1ml/kg bwt.) in olive oil [1:1 (v/v)] every other day for 8 weeks and by hepatic ischemia/reperfusion in adult male albino rats was studied. Different antioxidant and liver function parameters were reported to find the protective effect of both licorice and diclofenac sodium against hepatotoxicity. Results showed that licorice protected against CCl4-induced hepatotoxicity as well as ischemia/reperfusion-induced liver injury. On the other hand, diclofenac sodium caused deleterious effects, especially in presence of CCl4, where a high mortality rate was observed. (Source: Journal of Complementary and Integrative Medicine)

Antioxidant Activity of Combined Ethanolic Extract of Eclipta alba and Piper longum Linn

Journal of Complementary and Integrative Medicine — Wed, 07 Dec 2011 23:29:02 +0100

The in-vitro free radical scavenging efficacy of the combined ethanolic Biherbal extract (BHE) from equal quantities of the leaves of Eclipta alba and seeds of Piper longum was investigated. This was compared with its individual preparation of ethanolic extract of Eclipta alba (EAE) and ethanolic extract of Piper longum (PLE). The 1, 1, diphenyl -2-picrylhydrazyl (DPPH), super oxide, nitric oxide, hydroxyl radical scavenging activity and reducing power from BHE, EAE, and PLE were investigated employing various established in vitro systems. Total phenolic and flavonoid content were also determined. The results revealed that BHE has notable activity in quenching of DPPH, super oxide, nitric oxide, and hydroxyl radicals when compared to its individual preparation of EAE and PLE. The BHE at 10...

Extract of Valerian Root (Valeriana Officinalis L.) vs. Placebo in Treatment of Obsessive-Compulsive Disorder: A Randomized Double-Blind Study

Journal of Complementary and Integrative Medicine — Tue, 11 Oct 2011 21:26:15 +0100

Conclusion: The results suggest that Valeriana Officinalis L. has some antiobsessive and compulsive effects. However, further studies are needed to confirm these findings. Psychiatrists often find that many patients cannot tolerate the side effects of psychiatry medicine Valeriana Officinalis L. is a well-known medicinal plant with a long history of usage in world with effect on GABA.The results showed significant difference between the extract and placebo in the treatment of OCD. There was also no significant difference between the two groups in terms of observed side effects. (Source: Journal of Complementary and Integrative Medicine)

Combination Treatment of People with Multiple Sclerosis based on Collaboration between Conventional Healthcare Providers and Alternative Practitioners—Patient Perspectives on Outcomes

Journal of Complementary and Integrative Medicine — Tue, 27 Sep 2011 13:59:06 +0100

The use of alternative and complementary medicine (CAM) is prevalent among People with Multiple Sclerosis (PwMS) in Denmark as well as in other Western countries. Many PwMS combine conventional treatments and CAM; however there is little research-based knowledge about the outcomes that PwMS achieve from combined treatments. The purpose of this article is to describe which outcomes PwMS have experienced from combination treatment based on collaboration between conventional healthcare providers and CAM practitioners. A second purpose is to identify and study aspects of the courses of treatment that have generally characterized the achieved outcomes. During the course of their treatment, 59 PwMS participated in semi-structured individual or group interviews. The analyses show that the ...

Effect of Chloroform and Aqueous Basic Fraction of Ethanolic Extract from Apium graveolens l. In Experimentally-Induced Hyperlipidemia in Rats

Journal of Complementary and Integrative Medicine — Tue, 27 Sep 2011 13:59:03 +0100

The present study was undertaken to explore the antihyperlipidemic effect of ethanolic extract of seeds of Apium graveolens L. and its chloroform and aqueous basic fraction in olive oil induced hyperlipidemic rats. The antihyperlipidemic activity of Apium graveolens was compared with a standard drug Atrovastatin (50mg/kg). The study involved phytochemical screening and chromatographic studies of extract and fractions. The ethanolic extract and its fractions were administered orally at doses of 200 and 400 mg/kg body weight in rats. Olive oil (5ml/kg oral dose) was administered 30 min after treatment. Blood was collected by ocular puncture 2 and 4 h after olive oil treatment and centrifuged at 3000 rpm for 15-20 min. Serum samples were further subjected to biochemical analysis. The study do...

Effect of Wrightia tinctoria and Parthenocissus quinquefolia on blood glucose and Insulin levels in the Zucker Diabetic Rat Model

Journal of Complementary and Integrative Medicine — Wed, 20 Jul 2011 05:48:45 +0100

The aim of this study is to evaluate the antidiabetic activity of two Indian Ayurvedic herbs using an oral glucose tolerance test and blood insulin levels to understand the mechanism of action using the Zucker diabetic rat model. Herbal extracts of Wrightia tinctoria and Parthenocissus quinquefolia at a dose of (250 mg/kg body weight) were used throughout the study. Following a glucose challenge of 2 gm/kg using oral gavage, a timed glucose tolerance test was used to determine the ability of these extracts to alter glucose levels in diabetic animal model. The glucose lowering activities of these extracts were then compared to the controls. Both tested herbal extracts have shown to exhibit significant (P < 0.05) hypoglycemic activity compared to the control. W. tinctoria and P. quinquefolia...

Study of Antiobesity Effects of Ethanolic and Water Extracts of Grapes Seeds

Journal of Complementary and Integrative Medicine — Wed, 20 Jul 2011 05:48:42 +0100

Grapes seeds are rich source of polyphenolic compounds with potent antioxidant and have been reported beneficial for several health ailments. In the present study, the anti-obesity effect of grape seed extract in an animal model of high fat diet-induced obesity was investigated. Analysis of physiological parameters of high fat diet fed rats when treated with ethanol and water grape seeds extracts revealed significant (P (Source: Journal of Complementary and Integrative Medicine)

Studies on the Antiulcer and Gastrointestinal Effects of Stem Bark Extract of Bridelia ferruginea

Journal of Complementary and Integrative Medicine — Wed, 20 Jul 2011 05:48:36 +0100

The antiulcer and gastrointestinal effects of methanol stem bark extract (BFME) of Bridelia ferruginea Benth. (Euphorbiaceae) and its solvent fractions—dichloromethane (DCMF) and methanol (MF)—were studied using indomethacin- and ethanol-induced ulcers in rats, small intestinal transit of charcoal meal in mice, and the effects on acetylcholine-induced contractions of the isolated guinea pig ileum. The extract and fractions significantly (PMF>BFME. On the guinea pig ileum, MF (0.05 – 6.40 mg/ml) elicited no inhibition, DCMF (5 – 40 μg/ml) antagonized acetylcholine-induced contractions of the guinea pig ileum with IC50 of 10.47μg/ml, while BFME (0.05 – 12.80 mg/ml) contracted the guinea pig ileum with EC50 of 1 mg/ml. Oral LD50 of BFME in mice was estimated to be 2,154 mg/kg. Phy...

Impact of Mind Body Therapies on Vascular Endothelial Dysfunction and Implications for Cardiovacular Disease Management

Journal of Complementary and Integrative Medicine — Fri, 17 Jun 2011 22:00:16 +0100

Mind body therapies appear to reduce morbidity and mortality in patients with cardiovascular diseases, but there is limited understanding of the mechanisms that mediate this effect. Vascular endothelial dysfunction is a central feature of atherogenesis that is adversely impacted by mental stress. We conducted a systematic review and meta-analysis of the effect of mind body therapies on peripheral endothelial function in patients with and without established cardiovascular disease. The search included Medline, Cochrane Library, Scopus and Embase to identify studies up to November 2009. Eligible studies were randomized controlled trials that compared the effects of mind body therapies and placebo on endothelial function. Two reviewers extracted data on study characteristics, methods, and out...

Evaluation of Anti-inflammatory and Antioxidant Activity of Premna integrifolia Root

Journal of Complementary and Integrative Medicine — Tue, 14 Jun 2011 21:59:35 +0100

Roots of Premna integrifolia Linn. Mant. (Verbanacea) are important rasayana (Adaptogenic) drugs and are considered to be useful in the treatment of variety of ailments. The present study was aimed at evaluating the for its anti-inflammatory and antioxidant activities. Pretreatment with a single dose of methanolic extract of P. integrifolia (PIM) (300 mg/kg b.w.) produced significant inhibition on carrageenan-induced rat hind paw edema, histamine induced wheal formation, and acetic acid-induced mouse vascular permeation. In a 7-day study, daily administration of PIM suppressed formalin induced paw edema and cotton pellet-induced rat granuloma formation. The extract also showed significant inhibition of cyclo-oxygenase (COX-I) activity on rat uterus and plasma membrane stabilization. Apart ...

Pycnogenol (PYC) Induces Apoptosis in Human Fibrosarcoma (HFS) Cells Under Metal-mediated Oxidative Stress

Journal of Complementary and Integrative Medicine — Tue, 14 Jun 2011 15:59:31 +0100

Pycnogenol (PYC), polyphenolic compounds with antioxidant activity, acted as a prooxidant. PYC caused oxidative stress in human fibrosarcoma cells (HFS) when administered following pre-treatment with iron chloride. The generated reactive oxygen species (ROS) caused the formation of 8-hydroxy-2’-deoxyguanosine (8-OHdG) in DNA and resulted in more apoptosis in HFS cells than in the human fibroblastoma (HFB) cells. DNA damage and cellular viability at different PYC concentrations were closely consistent with cell growth, high performance liquid chromatography (HPLC), Enzyme Linked Immunosorbent Assay (ELISA) and assays of two major antioxidant enzymes, superoxide dismutase (SOD) and catalase. Although the presence of PYC induced total SOD and catalase activities under oxidative stress in do...

Antioxidant and Free Radical Scavenging Activities of Some Fruits

Journal of Complementary and Integrative Medicine — Tue, 14 Jun 2011 15:59:25 +0100

Phenols, a major group of antioxidant phytochemicals, have profound importance due to their biological and free radical scavenging activities. To identify their potential sources extracts of some fruits and their different parts were studied for total phenolic contents (TPC), antioxidant (AOA) and free radical scavenging activities (FRSA). The amount of TPC varied from 10.5 (Carissa carandus, fruit peel) to 343.2 mg/g (Caesalpinia Mexicana, fruits) and AOA from 20.3% (Musa paradisiacal, fruits) to 96.7% (Caesalpinia Mexicana, fruits). Fruits of Caesalpinia Mexicana, Acacia auriculiformis, fruit pericarp green fibres of Cocus nucifera, and fruits of Emblica officinalis were found to have high TPC (73.1-343.2 mg/g) and high AOA (68.5-96.7%). Promising fruits were studied for their FRSA and r...

Hepatoprotective Activity of Cyperus tegetum Rhizome Against Paracetamol-Induced Liver Damage in Rats

Journal of Complementary and Integrative Medicine — Wed, 08 Jun 2011 00:39:47 +0100

In present study the methanol extract of Cyperus tegetum rhizome (MECT) was evaluated for its effect on paracetamol-induced liver damage in Wistar rats. Serum biochemical parameters viz. serum glutamine oxaloacetate transaminase (SGOT), serum glutamine pyruvate transaminase (SGPT), serum alkaline phosphatase (ALP), total serum protein, total bilirubin content and liver biochemical parameters such as thiobarbituric acid reactive substances (TBARS) and reduced glutathione content were estimated. Biochemical and histopathological observations indicated that MECT had remarkable hepatoprotective effect against paracetamol-induced liver damage in rats. (Source: Journal of Complementary and Integrative Medicine)

Herbal Tonic Does Not Inhibit Estrogen Receptor Negative Mammary Tumor Development in a Transgenic Mouse Model

Journal of Complementary and Integrative Medicine — Tue, 07 Jun 2011 22:19:53 +0100

In this study four experimental groups of female MMTV-Neu mice were left untreated or treated with 3% Flor-Essence® in utero, from birth until 5 weeks of age, or throughout their lifetime. Palpable mammary tumor incidence and body weight was determined weekly for each group. The mice were sacrificed at 28 weeks of age and mammary tumors were enumerated to determine average tumor incidence and multiplicity for each group. Female mice exposed to Flor-Essence® herbal tonic in utero weighed significantly more than the control group (p < 0.001). The average tumor incidence and tumor multiplicity in the experimental mice treated with Flor-Essence® herbal tonic did not differ from the control animals. Flor-Essence® does not inhibit mammary tumor incidence or mammary tumor multiplicity in MMTV...

CAM in Canadian Hospitals: The New Frontier?

Journal of Complementary and Integrative Medicine — Tue, 07 Jun 2011 21:13:04 +0100

The provision in hospitals of traditional, complementary and alternative medicine (TCAM), as recognized by the World Health Organization, is now widespread in many of the world’s healthcare systems. As a significant part of integrative medicine (IM) or healthcare (IHC), research has now begun to focus on the varied parameters of hospital-based TCAM, however, little research has been conducted on the topic in the Canadian context. Drawing on a multi-site case study of four Canadian hospitals, qualitative observation was conducted at hospital sites, and interviews were conducted with senior hospital leaders and biomedical and TCAM hospital practitioners. The main focus of inquiry was to obtain the views of hospital leaders on the topic of incorporating TCAM, and to examine the motivations ...

Antihyperglycaemic And Renoprotective Effect of Boerhaavia diffusa L. in Experimental Diabetic Rats

Journal of Complementary and Integrative Medicine — Wed, 18 May 2011 23:36:59 +0100

The present study evaluates the efficacy of ethanolic extract of Boerhaavia diffusa L (BD) administered orally at a dose of 500mg/kg body weight for a period of 30 days to alloxanized diabetic rats and its efficacy compared with the standard hypoglycaemic drug metformin. Diabetic animals showed glycemic dysregulation, altered ionic balance, increased levels of serum markers of kidney function, and reduced Na+-K+ ATPase activity and endogenous antioxidant status. Administration of BD not only maintained the ionic balance and renal Na+-K+ ATPase activity but also significantly minimized diabetic hyperglycaemia. The renal antioxidant status (GPx, Catalase, SOD and GSH) remained in the near normal range and LPO level lower than the non-diabetic level. These effects are comparable to the change...

Two Case Reports on the Use of Genistein Combined Polysaccharide (GCP) Against Bladder Cancer Recurrence

Journal of Complementary and Integrative Medicine — Mon, 16 May 2011 17:52:38 +0100

We followed two subjects with resected stage Ta superficial transitional cell carcinoma (TCC) of the bladder who had not received intravesicle bacillus Calmette-Guerin (BCG) and received supplementation with the agent Genistein Combined Polysaccharide (GCP) in an IRB approved study. The observation period was 12 months for both cases. After the yearly oral dosage of GCP, there was no recurrence in either of the subjects as determined by cytoscopy, urine cytology, and fluorescence in-situ hybridization analysis of urine (UrovysionTM FISH Assay). The intravenous pyelogram (IVP), obtained at baseline and after 12 months, was also negative. There were no adverse events over the course of treatment and had full patient compliance and tolerability of the GCP agent in both cases. (Source: Journal...

Anti-Inflammatory, Antipyretic and Antioxidant Effect of Some Medicinal Plant Extracts

Journal of Complementary and Integrative Medicine — Mon, 02 May 2011 22:40:24 +0100

The anti-inflammatory, antipyretic and antioxidant effect of the methanol extract of Alhgi maurorum, Conyza dioscoridis and Convolvulus fatmensis was investigated. The anti-inflammatory effect was studied using carageenan-induced rat paw edema, while the antipyretic effect was estimated using Brewer's yeast-induced hyperpyrexia in rats. The antioxidant activity was evaluated using 2,2-diphenyl-1-picryhydrazyl (DPPH) free radical scavenging activity method of different concentrations of the plant extracts using ascorbic acid as a standard antioxidant. The results revealed that oral administration of Alhgi maurorum and Convolvulus fatmensis at 1 g/ kg exhibited anti-inflammatory effect comparable to the standard diclofenac sodium (0.03 g/kg). The anti-inflammatory effect of Conyza dioscoridi...

The Role of Complementary Indigenous Malay Therapies: Perspectives from Palliative Care Patients

Journal of Complementary and Integrative Medicine — Tue, 19 Apr 2011 18:31:28 +0100

Although the popularity of complementary indigenous Malay therapies (CIMT) in general healthcare is undeniable in the Malaysian context today, their usage within the palliative care scenarios remains unexplored. Our study was specifically embarked to determine CIMT’s usage pattern, reasons, attitudes, beliefs, perceptions and health-related quality of life (HRQoL) differences (users vs. non-users) in a sample of hospice-based palliative patients in Selangor, Malaysia. From the 39 consenting patients (mean age = 56 years; female = 56.4 percent; Malay = 53.8 percent), 38.5 percent were users of CIMT. Dried medicinal roots, herbs and sea cucumber products were the most preferred types of CIMT (53.3 percent). The most common reason cited for usage was because these were “easier and simpler...

Does Meditation Play an Integral Role in Achieving High-Level Wellness as Defined by Travis and Ryan (2004)?

Journal of Complementary and Integrative Medicine — Mon, 11 Apr 2011 18:44:39 +0100

In the emerging discipline of wellness, Travis and Ryan (2004) develop a dynamic theory of wellness that while not explicitly stated takes a systems theory approach to health and wellness. As a result, their theory of wellness resonates with many of the concepts and ideals experienced through a meditation practice. It is with this congruence in mind that the current paper explores whether there is any relationship between meditation and high-level wellness and if meditation techniques play an integral role in helping to achieve enhanced levels of wellness. A wide range of research across disciplines is reviewed, and despite controversies in the methodology employed to test meditation’s efficacy, it is readily apparent that numerous benefits or wellness outcomes are derived from a meditat...

Oxygen Bar Effectiveness: A Randomized Quantitative Study

Journal of Complementary and Integrative Medicine — Mon, 07 Mar 2011 18:09:05 +0100

This study was a quantitative experimental design and subjects were randomized in two groups. All subjects completed a Likert scale questionnaire that measured their energy, relaxation and stress levels. Baseline O2 saturation and heart rate were obtained using a pulse oximeter. Group 1 (n=15) received O2 via nasal cannula for the first 10 minutes and then again completed the questionnaire. During the following 10 minutes, the O2 bar remained on without O2 being administered to the subject. Afterwards, the same questionnaire was administered to the participants. Group 2 (n=15) followed the same protocol as above, except the experimental protocol was reversed. Using a repeated measures analyses of variance there were no significant differences between and within groups at each time period f...

Antibacterial and Antioxidant Activities of Synedrella nodiflora (L.) Gaertn. (Asteraceae)

Journal of Complementary and Integrative Medicine — Mon, 07 Mar 2011 18:08:57 +0100

The hexane, ethyl acetate, ethanol and water extracts of Synedrella nodiflora (L.) Gaertn. (Asteraceae) were assessed for their antibacterial and antioxidant capacities. The antioxidant capacities were evaluated using the ferric reducing antioxidant power (FRAP) and β-carotene bleaching assays. The antimicrobial activities were assessed using the classical pour-plate disc diffusion, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and death kinetic assays, against six bacterial strains. The ethanol extract displayed significant antioxidant capacities both in the FRAP and β-carotene bleaching assays. The ethanol extract abrogated the growth of all the bacteria tested. Folin-Ciocalteu and aluminium chloride spectrometry assays indicated the presence phenolic...

Chemical Characterization and Evaluation of the Hypoglycemic Effect of Fructooligosaccharides from Psacalium decompositum

Journal of Complementary and Integrative Medicine — Tue, 01 Mar 2011 22:53:31 +0100

Psacalium decompositum (Gray) H.E. Rob. & Brett (Asteraceae), popularly known as “matarique,” is a medicinal plant used in Mexico for the empirical treatment of diabetes mellitus. Previous studies with P. decompositum roots demonstrated that an aqueous fraction containing carbohydrates (WMP-fraction) exhibited a notable hypoglycemic effect in experimental animals. However, studies to identify these carbohydrates have not yet been performed. The goal of this investigation was to isolate and characterize the principal compounds in the WMP-fraction by spectroscopic and spectrometric analysis. Additionally, we sought to evaluate the hypoglycemic effect of these compounds in healthy and alloxan-induced diabetic mice. The results show that the chemical structures of the major compounds in th...

Effects of Improved Self-Appraisal and Mood Factors on Weight Loss in Obese Women Initiating Supported Exercise

Journal of Complementary and Integrative Medicine — Mon, 28 Feb 2011 17:28:03 +0100

This study aimed to test to what extent improvements in self-appraisal and mood factors were associated with changes in body mass index (BMI; kg/m2) and waist circumference. Women with obesity (N=171) completed Physical Self-Concept, Exercise Self-Efficacy, Body Areas Satisfaction, Tension, and Depression scales, and were measured on BMI and waist circumference, at baseline and just after a 24-week supported exercise program. With the exception of Physical Self-Concept, improvements on each psychological factor were associated with significantly greater weight and waist circumference improvements. Multiple regression analyses indicated that improvement/non-improvement on the psychological factors explained a significant 9 to 11 percent of the variance in BMI change, and 13 to 20 percent of...

Extract of North American Ginseng (Panax Quinquefolius), Administered to Leukemic, Juvenile Mice Extends their Life Span

Journal of Complementary and Integrative Medicine — Thu, 24 Feb 2011 01:10:06 +0100

In a recent study involving normal, juvenile mice, we showed that CVT-E002, a proprietary extract (Afexa Life Sciences, Inc.) of North American ginseng, Panax quinquefolius, significantly enhanced the absolute levels of cells acting at the first line of defense in tumor combat, i.e., natural killer (NK) cells. The present study evaluated the effect of CVT-E002, on life span when administered intraperitoneally to leukemic, infant/juvenile mice. The extract was administered to groups of mice daily for 14 days in several dosing groups up to 50mg/day from age 7 to 21 days. The tumor was administered intraperitoneally under sterile conditions, in a laminar flow hood at 7 days of age (0.5 x 106 leukemic cells), immediately preceding the first CVT-E002 injection for each dose group. The data reve...

In vitro (α-Glucosidase and α-Amylase Inhibition) and in vivo Antidiabetic Property of Phytic Acid (IP6) in Streptozotocin-Nicotinamide-Induced Type 2 Diabetes Mellitus (NIDDM) in Rats

Journal of Complementary and Integrative Medicine — Tue, 15 Feb 2011 23:27:11 +0100

Phytic acid, inositol hexaphosphate (IP6) a natural plant constituent and antioxidant exhibits protective action in carcinogenesis, Alzheimer’s, hypercholesterolemia, diabetes and inflammations when taken in diet. The aim of this study is to evaluate effect of phytic acid in streptozotocin (STZ)-nicotinamide-induced type 2 diabetes in rats. The STZ-nicotinamide induced diabetic rats were orally treated with vehicle (2%w/v Tween 80), glimepiride (2.5 mg/kg) and IP6 (650 mg/kg) for 28 days. The blood glucose level, body weight, glycosylated haemoglobin (HbA1C), lipid profile, lipid peroxidation, antioxidant status (liver and small intestine) was measured and compared with control. Xanthine dehydrogenase (XDH) and xanthine (XO) activity was measured in small intestine of diabetic rats. In v...

In vitro (Î±-Glucosidase and Î±-Amylase Inhibition) and in vivo Antidiabetic Property of Phytic Acid (IP6) in Streptozotocin-Nicotinamide-Induced Type 2 Diabetes Mellitus (NIDDM) in Rats

Journal of Complementary and Integrative Medicine — Tue, 15 Feb 2011 23:27:11 +0100

Phytic acid, inositol hexaphosphate (IP6) a natural plant constituent and antioxidant exhibits protective action in carcinogenesis, Alzheimerâs, hypercholesterolemia, diabetes and inflammations when taken in diet. The aim of this study is to evaluate effect of phytic acid in streptozotocin (STZ)-nicotinamide-induced type 2 diabetes in rats. The STZ-nicotinamide induced diabetic rats were orally treated with vehicle (2%w/v Tween 80), glimepiride (2.5 mg/kg) and IP6 (650 mg/kg) for 28 days. The blood glucose level, body weight, glycosylated haemoglobin (HbA1C), lipid profile, lipid peroxidation, antioxidant status (liver and small intestine) was measured and compared with control. Xanthine dehydrogenase (XDH) and xanthine (XO) activity was measured in small intestine of diabetic rats. I...

Hepatoprotective Effects and Antioxidant Role of Scutia myrtina on Paracetamol Induced Hepatotoxicity in Rats

Journal of Complementary and Integrative Medicine — Tue, 15 Feb 2011 00:14:49 +0100

The hepatoprotective effect and antioxidant role of ethanol extract of Scutia myrtina (EESM) was evaluated against paracetamol induced liver damage in rats. The degree of protection was measured by using biochemical parameters such as serum transaminase (SGPT and SGOT), alkaline phosphatase (ALP), bilirubin, total protein and uric acid. Further, the effects of the extract on lipid peroxidation (LPO), glutathione (GSH), Vitamin C and Vitamin E, superoxide dismutase (SOD), and catalase (CAT) were estimated. The ethanol extract of Scutia myrtina (EESM) (100 and 200 mg/kg) produced significant (P < 0.05) hepatoprotective effect by decreasing the activity of serum enzymes, bilirubin, and lipid peroxidation, while it significantly increased the levels of protein, uric acid, GSH, Vitamin C, Vitam...

Influence of Benefits, Barriers and Cues to Action for Complementary and Alternative Medicine Use among University Students

Journal of Complementary and Integrative Medicine — Sat, 12 Feb 2011 04:50:44 +0100

The purpose of the study was to explore the influence of perceived benefits, barriers, and cues to action on Complementary and Alternative Medicine (CAM) use among university students. This was a prospective, cross sectional questionnaire-based study conducted at a large urban university in Houston, Texas. Of the 400 students surveyed, 143 (35.8%) were current CAM users (used CAM in the past 12 months). Biologically based medications such as herbs, vitamins, supplements and natural products were found to be most profoundly used among students (42%). Perceived benefits (OR 9.14, 95% CI 4.64-18), barriers to CAM use (OR 0.49, 95% CI 0.27-0.89) and cues to action (OR 5.21, 95% CI 1.02-26.51) were significant determinants of CAM use among students. Perceived ability of CAM to improve body defe...

Potent Hypoglycemic Effect of Nigerian Anti-Diabetic Medicinal Plants

Journal of Complementary and Integrative Medicine — Thu, 10 Feb 2011 23:42:51 +0100

This study confirmed the traditional use of these Nigerian medicinal plants in diabetes treatment. These plants showed high potential for further investigation to novel anti-diabetic drugs. (Source: Journal of Complementary and Integrative Medicine)

Evaluation of Hypoglycemic Activity and Toxicity Profiles of the Leaves of Ficus deltoidea in Rodents

Journal of Complementary and Integrative Medicine — Thu, 10 Feb 2011 23:42:47 +0100

This study examined hypoglycemic and toxicity profiles of F. deltoidea leaf extract in rodent models. Extracts of dried powdered leaves were obtained using methanol solution, n-hexane, chloroform, and n-butanol. These extracts were orally administered to rodents. Their blood glucose and insulin levels, acute and subchronic toxicity, biochemical and histological profiles of liver and kidney were determined. Methanol extract exhibited blood glucose lowering activity in mildly insulin resistant diabetic rats as well as in normoglycemic mice unlike hydrophilic butanol subextract which only expressed its activity in normoglycemic mice. Methanol extract could contain both insulin receptor sensitization and secretagogue constituents. Different from toxic chloroform and hexane subextracts, hydroph...

Fenugreek Supplementation Imparts Erythrocyte Resistance to Cypermethrin Induced Oxidative Changes In Vivo

Journal of Complementary and Integrative Medicine — Thu, 10 Feb 2011 23:42:33 +0100

Erythrocytes are excellent model to study the xenobiotic induced oxidative changes. Pyrethroid pesticides are increasingly being used in insecticidal preparations from the simple mosquito coils to house hold aerosols to sophisticated ultra low volume foggers and sprays. Cypermethrin a Type II pyrethroid pesticide is used widely in pest control. Fenugreek is a potent antioxidant. We have evaluated the potential of aqueous extract of germinated fenugreek seeds in counteracting cypermethrin induced oxidative changes in erythrocytes of male Wistar rats. Male Wistar rats were treated with 1/10 LD50 (25mg/kg body weight) of cypermethrin and 10 percent aqueous extract of germinated fenugreek for 60 days. Cypermethrin treatment caused significant decrease in non enzymatic antioxidants, glutathione...

Glucose Uptake-Enhancing Activity of the Ethyl Acetate Extract of Dennettia tripetala in 3T3-L1 Adipocytes

Journal of Complementary and Integrative Medicine — Tue, 08 Feb 2011 23:31:11 +0100

In conclusion, EDT enhanced glucose uptake partly by the mobilization of glucose uptake proteins from the interior of the cell to plasma membrane via the Golgi apparatus. Therefore, this mechanism may be responsible for the antihyperglycaemic effect of EDT reported in our previous study. (Source: Journal of Complementary and Integrative Medicine)

Antihypertensive and Vasorelaxant Effects of Cinnamomum zeylanicum Stem Bark Aqueous Extract in Rats

Journal of Complementary and Integrative Medicine — Tue, 08 Feb 2011 23:31:05 +0100

The present study was undertaken to evaluate the antihypertensive and vasorelaxant effects of Cinnamomum zeylanicum Blume stem bark aqueous extract in rats. The in vivo activities of the extract were evaluated on normotensive and three rat models of hypertension while the in vitro tests were assayed on rat isolated aorta rings. Acute intravenous injection of the extract (5, 10 and 20mg/kg) induced a significant reduction in mean arterial blood pressure in anaesthetised normotensive Wistar rats, salt-loaded hypertensive, L-NAME hypertensive and spontaneously hypertensive rats. Pre-treatment of rats with either propranolol or atropine significantly inhibited the hypotensive effects of the plant extract suggesting its possible action through the interferences with both cholinergic and sympath...

Syzygium cumini Seed Extract Protects the Liver Against Lipid Peroxidation with Concurrent Amelioration of Hepatic Enzymes and Lipid Profile of Alcoholic Rats

Journal of Complementary and Integrative Medicine — Tue, 08 Feb 2011 23:30:57 +0100

The in vitro oxidative stress induced by ethanol/Fentonâs reaction in rat liver homogenates decreased significantly in the presence of Syzygium cumini seed extract, suggesting the protective effect of the seed extract against the oxidative stress in liver. To corroborate the in vitro effects by an in vivo experiment, 24 rats were divided into four groups: control, S. cumini seed-extract-administered (SE), 15% ethanol-fed (Alc) and Alc+SE rats. The oral administration of the extract (400 mg/kg BW.day) for 7 weeks significantly decreased the levels of liver LPO in the Alc+SE rats, suggesting that S. cumini seed not only obstructed the in vitro free radical production and subsequent oxidative stress, but also inhibited their in vivo formation. The oral administration of extract also redu...

Mechanism of the Hepatoprotective Activities of the Garcinia Hydroxybiflavanonol, GB1

Journal of Complementary and Integrative Medicine — Mon, 27 Dec 2010 23:57:00 +0100

Garcinia kola Heckel (Guttiferae) known as âAki-iluâ (meaning bitter kola) is a large economic tree indigenous to southern part of Nigeria. Its seeds have been of interest to researchers because of its use in the treatment of various disease conditions in Nigerian traditional medicine. The influence of the Garcinia hydroxybiflavanonol, GB1 on the membrane of primary cultured rat hepatocytes was studied. This work provides the first concrete evidence on the membrane stabilizing action of the hepatoprotective principle of Garcinia kola nuts. Results demonstrated that at high concentrations, the Garcinia hydroxybiflavanonol, GB1 as well as silibinin interact very strongly with the protein components of the liver cell membrane thereby causing an unspecific inhibition of the different...

In Vitro Antiplasmodial and Cytotoxic Activities of Ethanol Extracts of Apical Stem of Phyllanthus amarus Schum. et Thonn. (Euphorbiaceae)

Journal of Complementary and Integrative Medicine — Thu, 23 Dec 2010 17:57:46 +0100

The in vitro antiplasmodial and cytotoxic activities of ethanol extracts from whole plant, fresh apical stems and calli from fresh apical stem of Phyllanthus amarus cultured on Murashige and Skoog (MS) medium supplemented with indole-butyric acid (IBA)/benzylaminopurine (BAP) 1:1, 1:2, 1:4 and 1:4, IBA/BAP/mannitol 1:1:0.5%, IBA/BAP/mannitol: 2% for three months were evaluated. Results indicated that all ethanol extracts showed an in vitro antiplasmodial activity at different extends. The most active ethanol extract was that from callus cultivated with IBA/BAP/mannitol 1:1:05% (IC50 < 0.19 Âµg/ml). The ethanol whole plant and intact apical stem extracts exhibited an activity with IC50 values of 2.5 Â± 0.4 and 8.2 Â± 1.9 Âµg/ml, respectively. Quercetin, lupeol and ellagic acid displ...

Clinical Research on Diabetic Foot Ulcers: Demonstration of a Comprehensive Methodology

Journal of Complementary and Integrative Medicine — Wed, 15 Dec 2010 08:08:20 +0100

The best way to approach research on Chinese medicine would be one that takes full reference to the methodology being used in modern medicine. This would enable traditional medicine to be elevated to a level of universal acceptance. However, problems lie in difficulties to achieve uniform herb supply; randomization and placebo arrangement in clinical trials; and uncertain chemical structures and pharmacological effects. A detailed account is given on the clinical research on diabetic foot ulcers, in which a strictly evidence-based, placebo-controlled, randomized clinical trial was conducted, while parallel mechanistic studies were done in the laboratory and the herbs used were adequately authenticated at the same time. The encouraging clinical efficacy supports further studies encouraged b...

Prevention of Cisplatin-Induced Nephrotoxicity by Ethanolic Extract of Embelia ribes Fruits and α-Tocopherol in Experimental Animals

Journal of Complementary and Integrative Medicine — Tue, 14 Dec 2010 04:56:11 +0100

Oxidative stress due to abnormal production of reactive oxygen species (ROS) is believed to be involved in the etiology of toxicity of many xenobiotics. Evidence suggests that in cisplatin-induced nephrotoxicity, ROS is involved. We studied the nephroprotective effects of ethanol extract of Embelia ribes fruits alone and in combination with vitamin E (α-tocopherol) in cisplatin (12mg/kg i.p)-induced nephrotoxicity in mice. The results of the study indicated that Embelia ribes fruits significantly and dose dependently protected the cisplatin-induced nephrotoxicity. The serum urea, creatinine and blood urea nitrogen levels in cisplatin alone treated groups were significantly elevated (P < 0.01) with respect to control group. The serum urea, creatinine and blood urea nitrogen levels were red...

Prevention of Cisplatin-Induced Nephrotoxicity by Ethanolic Extract of Embelia ribes Fruits and Î±-Tocopherol in Experimental Animals

Journal of Complementary and Integrative Medicine — Tue, 14 Dec 2010 04:56:11 +0100

Oxidative stress due to abnormal production of reactive oxygen species (ROS) is believed to be involved in the etiology of toxicity of many xenobiotics. Evidence suggests that in cisplatin-induced nephrotoxicity, ROS is involved. We studied the nephroprotective effects of ethanol extract of Embelia ribes fruits alone and in combination with vitamin E (Î±-tocopherol) in cisplatin (12mg/kg i.p)-induced nephrotoxicity in mice. The results of the study indicated that Embelia ribes fruits significantly and dose dependently protected the cisplatin-induced nephrotoxicity. The serum urea, creatinine and blood urea nitrogen levels in cisplatin alone treated groups were significantly elevated (P < 0.01) with respect to control group. The serum urea, creatinine and blood urea nitrogen levels were r...

Medicinal Plants with Potential Galactagogue Activity Used in the Moroccan Pharmacopoeia

Journal of Complementary and Integrative Medicine — Mon, 13 Dec 2010 00:05:10 +0100

The present study aims to describe the medicinal plants used as galactagogues in Moroccan traditional medicine. The study is based mainly on the literature, surveys and reports of practitioners and herbalists. Eighteen plants are identified. We have indicated the scientific name of the plant, its family, its other medicinal uses and its toxicity once detected. Galactagogue drugs as opposed to both alternative herbal therapy and the physiological mechanisms of actions of these plants are appropriately discussed. The main galactagogue plants families used in Moroccan pharmacopoeia are: Apiaceae (4 species), Ranunculaceae (3 sp.), Urticaceae (3 sp.) and Fabaceae (2 sp). One quarter of these plants shows some degree of toxicity when the dosage is high: Aristolochia longa, Pimpinella anisum, ...

Amelioration of Inflammation Induced Oxidative Stress and Tissue Damage by Aqueous Methanolic Extract of Nigella sativa Linn. in Arthritic Rats

Journal of Complementary and Integrative Medicine — Fri, 10 Dec 2010 20:22:35 +0100

This study is an attempt to identify targets of inflammation in joints and amelioration of the disease process by a natural product. Wistar rats were immunised with collagen, disease developed after 13Â±1 days post induction. Nigella sativa Linn. aqueous methanolic extract was given at two diffferent dosages, viz. 400 and 500 mg/kg daily until the 20th day. The analysis of inflammation and associated protease activation was evaluated by myeloperoxidase (MPO) and articular elastase (ELA). Post inflammatory generation of various free radicals was checked by evaluating several enzymatic and non enzymatic parameters (GSH, SOD and catalase), including peroxidation of membranes. Finally, articular nitrite content was estimated as to highlight the tissue injury evidenced by histology caused by...

In Vitro Antioxidant Activity of Extracts and Coumarins from the Stem Bark of Mammea africana Sabine

Journal of Complementary and Integrative Medicine — Tue, 23 Nov 2010 23:55:35 +0100

The present study aimed at evaluating the in vitro antioxidant activity (AOA) of the aqueous and methylene chloride/methanol (CH2Cl2-MeOH) extracts of Mammea africana and isolating the active principle(s). The AOA of the aqueous and CH2Cl2-MeOH extracts (3-1000 Âµg/ml) as well as compounds isolated (1-300 Âµg/ml) through bio-guided fractionation of the CH2Cl2-MeOH extract was evaluated using 1,1-diphenyl-2-picrylhydrazyl (DPPH), nitric oxide (NO) production and beta carotene bleaching tests. The aqueous and CH2Cl2-MeOH extracts exhibited a concentration dependent antiradical activity on DPPH with respective EC50 of 2.00 and 5.24 Âµg/ml. The purification of the CH2Cl2-MeOH extract yielded two coumarins: 4-phenylcoumarins (1) and 4-n-propylcoumarins (2) that exhibited potent radical sc...

Yoga and Physical Activity: The Effect of Meditation

Journal of Complementary and Integrative Medicine — Mon, 22 Nov 2010 17:35:39 +0100

I read with a great interest the article by Buranruk and colleagues (2010) regarding measurements of cardio-respiratory parameters to assess the intensity of physical exercise in healthy adults practicing Thai Yoga. The authors conclude that a 30 minute long Thai Yoga session is commensurate to a very light to light intensity exercise. It is noteworthy that the measured physiological parameters (e.g., heart rate, VO2 max) are the function of the subtle interplay between relaxation techniques aimed at slowing down the metabolic rate by eliciting parasympathetic effect, and physical stimulation that, on the other hand, result in a strong sympathetic response. That is, it can be deduced that the levels of relaxation that one engaged in throughout the Yoga session mediates the effect of physic...

Efficacy of Betel Cream on Skin Ailments

Journal of Complementary and Integrative Medicine — Mon, 22 Nov 2010 17:28:45 +0100

In Sri Lanka, freshly squeezed juice of Piper betle (Family: Piperaceae) leaves is used as a remedy for skin ailments. Therefore, a cream was formulated by incorporating essential oil and cold ethanolic extract of betel leaves into Vaseline and a clinical study was performed to evaluate the efficacy of the above cream. A double blind, vehicleâcontrolled randomized study was performed for a period of 14 days. There was a significant healing effect on skin ailments when patients were treated with betel oil and cold ethanolic extract incorporated cream. (Source: Journal of Complementary and Integrative Medicine)

Crude Aqueous Extract of Garlic Reduces MIC of Isoniazid and Rifampicin Against Mycobacterium Tuberculosis by Broth Microdilution Method

Journal of Complementary and Integrative Medicine — Fri, 19 Nov 2010 00:18:39 +0100

Garlic extract is known to possess anti-mycobacterial property. The present study evaluates the effect of crude aqueous extract of garlic on MIC of isoniazid and rifampicin against drug sensitive strains. Crude aqueous extract of garlic was prepared according to method described by Fromtling and Bulmer. Clinical isolates of MTB were obtained from patients reporting to the hospital and were used for the study after antibiotic sensitivity testing. Sensitivity testing for isoniazid and rifampicin alone and in combination with different dilutions of aqueous extract of garlic was performed in 96-well microtitre plates. H37Rv was used as control strain for the study.Crude aqueous extract of garlic alone inhibited the growth of clinical isolates of MTB in dilution of 2.64+1.24 ul/100ul of broth. ...

Functional Foods and Herbs as Potential Immunoadjuvants and Medicines in Maintaining Healthy Immune System: A Commentary

Journal of Complementary and Integrative Medicine — Fri, 19 Nov 2010 00:18:33 +0100

Herbs and traditional foods have been demonstrated for their effectiveness on lifestyle-related diseases like diabetes, heart diseases, hypertension, arthritis and cancer as well as special health benefits towards body defensive mechanism(s) by strengthening immune system. Some herbs have been identified as important for daily maintenance of immune system and classified as immunotonics, which include immunostimulants, immunomodulators or immunoadjuvants. These immuno agents are known to exert overall balancing effect on immune system and are expected to augment or promote defensive system. The second category of herbs identified is largely useful for the treatment immune disorders or compromised immune system. Herbs or ayurvedic preparations with immunostimulant property have traditionally...

Acute Toxicity and Antioxidant Activity of Hydroethanolic Extract of Solenostemon monostachyus P. Beauv. Leaves

Journal of Complementary and Integrative Medicine — Tue, 16 Nov 2010 23:42:25 +0100

Acute toxicity and antioxidant activity of hydroethanolic leaves extract of Solenostemon monostachyus (Esomo) were investigated. The method used for antioxidant evaluation was 2, 2-Diphenyl-1-picrylhydrazyl (DPPH) and the method of Miller & Tainter was employed for the acute toxicity. The lethal dose inducing death for half of tested mice (LD50) for Esomo was 1.9Â± 0.001 g/kg body weight. According to the classification of Diezi (1989), this drug is weakly toxic. Esomo's concentration at 50% DPPH radical scavenging activity (IC50) was 19.95 Â± 0. 1Âµg/ml. Esomo (100 Âµg/ml) induced a DPPH scavenging activity of 86.25 %. Similar results were obtained with acid gallic and ascorbic acid applied at the same concentration and they induced a DPPH scavenging activity of 91.66% and 98%, re...

Abstracts from the Sixth IN-CAM Research Symposium: Complementary and Integrative Health Care: Methodological, Theoretical and Practical Issues

Journal of Complementary and Integrative Medicine — Wed, 03 Nov 2010 21:06:26 +0100

The following are abstracts of oral and poster presentations given at the sixth IN-CAM Research Symposium, Complementary and Integrative Healthcare: Methodological, Theoretical and Practical Issues, held November 19 to 21, 2010 at the Sutton Place Hotel, Vancouver, Canada. The Symposium was held in collaboration with IN-CAM partners PedCAM and HomeoNet. The abstracts are grouped under: IN-CAM, PedCAM, and HomeoNet. For more information, please visit: www.incamresearch.ca. (Source: Journal of Complementary and Integrative Medicine)

Anticancer Activity of Guava (Psidium guajava) Extracts

Journal of Complementary and Integrative Medicine — Mon, 01 Nov 2010 17:21:15 +0100

A literature search was conducted on Medline for research articles relating guava (Psidium guajava) to cancer, in order to determine any potential anticancer activity. The keyword "guavaâ was used in combination with cross-referencing (1952 to September, 2010). A total of 373 articles on guava resulted of which 12 were related to cancer. These were then categorized into 1) seven studies on in vitro cancer cell line studies with leaf extracts, 2) five studies on in vitro studies with fruit extract, and 3) one in vivo mouse study. The majority of remaining articles covered chemical constituents and potential bioactives related to anticancer activity found in guava leaves, fruit and bark. Our review revealed that guava extracts (primarily leaf) may have anti-cancer activity, but this is ...

Bio-Evaluation of Two Red Seaweeds for Their Cytotoxic and Antioxidant Activities In Vitro

Journal of Complementary and Integrative Medicine — Mon, 01 Nov 2010 17:21:11 +0100

This article evaluates the cytotoxic and antioxidant activities of the seaweeds Amphiroa fragilissima and Asparigopsis taxiformis methanolic extracts in-vitro. The aim of this study was to test the selected red seaweed extracts for their cytotoxic activity by Brine shrimp lethality assay and antioxidant properties by in-vitro free radical scavenging assays such as, 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay, reducing power assay, and metal ion chelating assay. Also, the total phenolic content (TPC) of the seaweed extracts was also determined. In the brine shrimp lethality test, A. fragilissima and A. taxiformis demonstrated mild cytotoxic activity of 53.33 Â± 2.58 and 58.33 Â± 2.58 % at the highest concentration of 0.5mg/ml and 24 h incubation time. The total phenol...

Antibacterial Activity of Wendlendia tinctoria DC

Journal of Complementary and Integrative Medicine — Mon, 01 Nov 2010 17:21:05 +0100

The antibacterial activity of hexane, ethyl acetate, n-butanol, water extract of W. tinctoria and stigmasterol isolated from ethyl acetate extract were evaluated. Ethyl acetate, water extract and stigmasterol showed significant activity against five species of bacterium in comparison to Streptomycin antibiotic. The results obtained in the present study authenticate and support the use of these plants in folklore medicine for treatment of various infectious diseases caused by the bacterial pathogens. These findings will stimulate the search for novel, natural products as new antibacterial agents that may be useful to pharmaceutical industries. (Source: Journal of Complementary and Integrative Medicine)

Protective Effects of Phyllanthus acidus (L.) Skeels Extract on Acetaminophen Mediated Hepatic Injury and Oxidative Stress in Wistar Rats

Journal of Complementary and Integrative Medicine — Fri, 22 Oct 2010 18:01:54 +0100

Phyllanthus acidus (L.) Skeels fruit is used as a liver tonic in Indian traditional medicine. The present study was undertaken to investigate the protective effects of ethanolic extract (70%) of Phyllanthus acidus fruits (PAE) on acetaminophen (paracetamol, APAP) induced acute hepatotoxicity in Wistar rats. The effect on cytochrome P450 enzyme system using pentobarbital induced sleeping time (PST) and free radical scavenging potential using 2,2-diphenyl-1-picrylhydrazil (DPPH) was also determined. Hepatotoxicity was achieved by administering a single oral dose of APAP (2 g/kg). PAE administered at a dose of 125, 250 and 500 mg/kg, p.o. showed a significant hepatoprotection against APAP-liver toxicity as evidenced by reduced serum markers and histopathological observation of liver tissues. ...

Orchis anatolica Root Ingestion Improves Sexual Motivation and Performance in Male Rats

Journal of Complementary and Integrative Medicine — Fri, 01 Oct 2010 18:50:01 +0100

This study investigates the effects of ingestion of dried O. anatolica root on the sexual behavior and weights of reproductive organs in adult male rats. Sexually active male rats were divided into two groups (control and experimental). O. anatolica root powder was orally administered to the experimental group in a daily dose of 1g/kg for thirty days. The sexual behavior was then monitored and compared between O. anatolica treated rats and control rats. Weights of reproductive organs and testosterone serum levels were, also, measured for both treated and control rats. O. anatolica root ingestion significantly reduced the mount, intromission, and ejaculation latencies. Also, a significant increase in the copulatory efficacy was reported. Weights of reproductive organs and testosterone serum...

Trigonella foenum graecum Prevents Pathological Exacerbation by Toxic Insults Following Chronic Restraint Stress in Mice Skin

Journal of Complementary and Integrative Medicine — Thu, 23 Sep 2010 23:26:24 +0100

In this study, the effect of chronic restraint stressed mice skin treated with trichloroethylene (TCE) (200 µL of 80% v/v) and subsequently exposed to UVB (0.42 J/m2/s) has been evaluated. The inflammatory and oxidative damage so caused were restored by application of Trigonella foenum graecum. As compared to the non stressed toxicant groups, all the antioxidant enzymes following restraint stress (RS) â glutathione reductase (GR) (p (Source: Journal of Complementary and Integrative Medicine)

Exploring the Integration of Complementary Medicines into Australian Pharmacy Practice with a Focus on Different Practice Settings and Background Knowledge

Journal of Complementary and Integrative Medicine — Mon, 20 Sep 2010 02:37:02 +0100

The widespread use of complementary medicines (CMs) within the general community, the health benefits and risks, and the role of pharmacists as advocates of appropriate use of medicines make it imperative to identify how pharmacistsâ meet customers CM information needs and lead quality use of medicine practices in regards to CMs within the pharmacy setting. A self-administered questionnaire was completed by 736 Australian pharmacists as part of a larger study on the use of CM within pharmacy practice. Personal use of CMs was common (76%). Most pharmacists saw CM counselling as their professional obligation, however, mainly regarding safety aspects. Only 24% of pharmacists always asked customers presenting with prescription medicines about concomitant CM use. Only 34% of pharmacists pe...

Factors Predicting the Recommendations of General Practitioners on Herbal Therapies and Dietary Supplements to Patients

Journal of Complementary and Integrative Medicine — Mon, 20 Sep 2010 02:37:01 +0100

The aims of the study were to determine the attitudes of General Practitioners (GPs) on herbal therapies and dietary supplements (H/DS) and to identify factors that predict their recommendations. A self-administered mailed survey was carried out in New South Wales, Australia in 2004. 288 GPs participated in the survey. Twenty percent of GPs had education in this topic, and less than one-third felt confident advising their patients. Forty-seven percent of GPs did not inquire about the use of H/DS regularly. The key factors that predicted GPs recommending H/DS were: belief that H/DS are useful for more than one condition, belief that most H/DS have some benefit, discussion of use of H/DS in the last 30 days, personal use of H/DS, and fewer years of clinical practice. GPsâ primary concer...

Administration of Omega-3 Fatty Acids Reduces Positive Tender Point Count in Chronic Musculoskeletal Pain Patients

Journal of Complementary and Integrative Medicine — Mon, 20 Sep 2010 02:36:57 +0100

Dietary supplementation of omega-3 (n-3) is becoming increasingly popular as a complementary treatment of chronic inflammatory pain diseases. The aim of the present study was to examine the effects of short-term (35 days) n-3 supplementation on physiological/psychophysical variables and clinical symptoms in patients with musculoskeletal pain and fibromyalgia. Patients (N=41, all women), blindly assigned to two groups according to dietary supplementation (fish oil containing n-3 or sunflower oil), underwent quantitative sensory testing and completed questionnaires concerning anamnestic/epidemiological data, pain characteristics and mood. In the n-3 group there was a sharp reduction in both the arachidonic acid/eicosapentaenoic acid ratio (AA/EPA) and the number of positive tender points, ...

Plasma Serotonin and Interleukin 18 Levels after Taking Powdered Processed Aconiti Tuber

Journal of Complementary and Integrative Medicine — Mon, 20 Sep 2010 02:36:54 +0100

Processed Bushi Powder for Ethical Dispensing, called TJ-3022 (Aconitum carmichaeli Debeaux), is a herbal drug of processed Aconiti tuber (PAT) and TJ-3023 newly developed to contain a higher proportion of diester alkaloid of aconitine (Aconitum carmichaeli Debeaux and Aconitum japonicum Thunberg). Serotonin (5-HT) and 5-HA receptors are involved in cytokine production in infection or sepsis. Interleukin (IL)-18 is known to be one of key mediators in patients with severe organ dysfunctions. We measured the level of 5-HT and IL-18 in healthy adult volunteers and assessed whether PAT inhibits the production of 5-HT or IL-18. Thirty subjects were assigned to one of two groups: the TJ-3022 group or TJ-3023 group. The subjects received powdered PAT 3 g/day for 3 days and the blood concentration...

Complementary and Alternative Medicine in Psychotic Disorders

Journal of Complementary and Integrative Medicine — Sat, 04 Sep 2010 17:12:25 +0100

The use of complementary and alternative medicine (CAM), including alternative therapies (ALT) and natural health products (NHP) such as vitamin and herbal supplements, is increasingly accepted in both the general population as well as in patients with mood and anxiety disorders. The level of acceptance and use of CAM, however, is unknown among patients being treated for psychotic disorders. Psychotic patients were surveyed about their use of and attitudes toward CAM. Questions included basic demographic and socio-economic items as well as the lifetime and 12-month use of CAM. Data were collected from June to October 2005. A sample of 172 participants representing 8.4% of the total eligible population of the outpatient clinics within the Schizophrenia Program at the Centre for Addiction an...

Protective Effects of Icosahydropicenic Acid Isolated from the Roots of Clerodendrum serratum (L) Moon on Experimental Allergic Asthma

Journal of Complementary and Integrative Medicine — Sat, 04 Sep 2010 17:12:22 +0100

Plant saponins are widely distributed amongst plants and have a wide range of biological properties. Icosahydropicenic acid (IHPA), a new pentacyclic triterpenoid saponin was first time isolated from the roots of Clerodendrum Serratum (L) Moon (Verbenaceae). IHPA, at the dose of 100mg/kg, showed significant protection of mast cell degraualtion (59.62%) as compared to standard sodium cromoglycate (64.48%). The compound also revealed significant inhibitory activity on histamineâinduced goat tracheal chain preparation. The study provides scientific basis for its clinical use in the treatment of asthma. (Source: Journal of Complementary and Integrative Medicine)

Pharmacological Evaluation of Ayurvedic Plants for Aphrodisiac Activity in Experimental Animals

Journal of Complementary and Integrative Medicine — Sat, 04 Sep 2010 17:12:19 +0100

Vajikaran Chikitsa is the branch of Ashtanga Ayurveda, which deals with all types of physical and psychological sexual problems like impotence, libido, poor erection, and early ejaculation in males. The WHO estimated that the usage of traditional medicine in developing countries is 80% and suggested a need for further exploration of the natural aphrodisiacs for the mechanism of action. Considering the prevalence of the sexual dysfunctioning in the society, side effects with the conventional aphrodisiac drugs, the study was planned to evaluate some Ayurvedic plants like Abutilon indicum and Withania somnifera for the aphrodisiac potential. An attempt was also made to elucidate the possible mechanism of action of these plants for their use in Vagikarana chikitsa. From the present study, it c...

Supplementation of Fruit Extract of Hippophae rhamnoides Speeds Adaptation to Simulated High Altitude Stressors in Rats

Journal of Complementary and Integrative Medicine — Tue, 03 Aug 2010 06:48:16 +0100

The present study was conducted to evaluate the adaptogenic activity of aqueous fruit extract of seabuckthorn (Hippophae rhamnoides L) in rats simulated to high altitude conditions along with its toxicity studies. In one of the studies, various doses 25, 50, 75, 100 and 200 mg/kg of extract were administered in rats 30 minutes prior to cold (5Â°C)âhypoxia (428 mmHg)ârestraint (C-H-R) exposure. The maximal effective adaptogenic dose of the extract was observed to be 75 mg/kg body weight. In a second study, biochemical studies related to lipid peroxidation and antioxidant status of rats exposed to C-H-R alone or in presence of extract were examined. The supplementation of extract attenuated the changes in levels of malondialdehyde and reduced glutathione, and activities of glutat...

Effect of Hygrophila spinosa T. on Reproductive Function of Male Albino Rats

Journal of Complementary and Integrative Medicine — Fri, 30 Jul 2010 16:24:56 +0100

Hygrophila spinosa T. Anderson, commonly known as Gokulakanta (Hygrophila) is a well known medicinal plant found in all over India. The different parts of the plant are used to treat various diseases in the folklore medicine as the seeds are given by hakims with âsugar, milk or wineâ for the treatment of impotence, gonorrhea and spermatorrhoea. Active constituents such as steroids and glycosides which are under investigation, reported to possess spermatogenetic potential and the phytochemical screening has shown positive for steroids and glycosides. The present study have been carried out to investigate and evaluate the aphrodisiac activity and spermatogenetic potential of ethanolic extract of the seeds of H. spinosa (EEHS) on ethanol induced rat model for testicular injury. The ...

Traditional Cambodian Medicine

Journal of Complementary and Integrative Medicine — Mon, 12 Jul 2010 08:34:09 +0100

In 2006 and 2007, the authors visited Siem Reap, Cambodia for eight weeks. To understand the spectrum of Cambodian healthcare, we investigated traditional medical practices and herbal medicines in addition to Western medical practice. Our hosts were English-speaking physicians and translators. At the provincial hospital medicine/surgical wards, government satellite clinics, pharmacies, and street vendors, we inquired about and observed Cambodian traditional medical practices. We supplement these observations with literature review. Traditional Cambodian medical practices are widely used. They share with Chinese medicine three explanatory models of disease: supernaturalistic theory, naturalistic theory, and maintenance of âhot/coldâ (âyin/yangâ) balance. Four forms of th...

Spirituality and Well-Being Among Persons with Diabetes and Other Chronic Disabling Conditions: A Comprehensive Review

Journal of Complementary and Integrative Medicine — Thu, 08 Jul 2010 16:56:53 +0100

This paper examines the theoretical literature on the influence of spirituality on general health and relevance to patient care. The literature suggests that the recognition of spirituality as the basis of meaning in life can lead to fruitful insights for the care and support of many patients who suffer from a variety of health conditions. (Source: Journal of Complementary and Integrative Medicine)

Ethno-Medico-Botanical Knowledge of Khare-vokkaliga Community in Uttara Kannada District of Karnataka, India

Journal of Complementary and Integrative Medicine — Thu, 08 Jul 2010 16:54:16 +0100

This study reports 11 new claims for the treatment of human diseases and disorders. (Source: Journal of Complementary and Integrative Medicine)

Influences of Family Environment and Meditation Efficacy on Hemodynamic Function among African American Adolescents

Journal of Complementary and Integrative Medicine — Thu, 08 Jul 2010 15:37:49 +0100

This study examined the impact of breathing awareness meditation (BAM) compared to health education (HE) and lifeskills training (LS) upon resting systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) within the context of potential moderating factors of family environment and expectancy of benefit. 186 African American adolescents (mean age: 15.1Â±0.7 yrs) were randomly assigned by school to three-month BAM, LS, or HE interventions. Laboratory resting blood pressure (BP), Family Relations Index (FRI) and expectancy of benefit evaluations were conducted at pre- and post-intervention. Higher expectancy of benefit from any of the three interventions resulted in greater reductions in SBP. A two-way interaction indicated that BAM group subjects who came from posit...

Anxiolytic Effect of Flowers of Salix aegyptiaca L. in Mouse Model of Anxiety

Journal of Complementary and Integrative Medicine — Fri, 02 Jul 2010 16:23:21 +0100

The aim of the present study was to evaluate the anxiolytic effects of total extract of flowers of Salix aegyptiaca on the elevated plus-maze (EPM) model of anxiety. The extract of the flower parts of the plant was administered by i.p. and p.o. to male NMRI mice, at various doses. Oral and i.p. administration of the S. aegyptiaca significantly increased the percentage of time spent in the open arms of the EPM at 200 and 100 mg/kg, respectively. The plant extract at 100 and 200 mg/kg significantly decreased the animal's locomotor activity at 10 and 15 min time intervals. These doses, however, did not affect the ketamine-induced sleeping time. The 100 mg/kg dose of the plant extract when given by i.p. route seemed to be the optimal dose in producing the anxiolytic effects. Lack of interactio...

Anti-Inflammatory and Antinociceptive Activities of Methanol Extract and Alkaloid Rich Fraction of Mitragyna parvifolia Stem-Bark in Animal Models

Journal of Complementary and Integrative Medicine — Fri, 02 Jul 2010 16:23:19 +0100

Mitragyna parvifolia (Roxb.) Korth (Rubiaceae) is widely used as an acrid, anodyne, bitter, stomachic, febrifuge, and in the treatment of gastropathy, colic, fever, and inflammation. In the present study, the anti-inflammatory and antinociceptive properties of the stem bark methanol extract (MPBM) extracted by Soxhlet extraction and alkaloid rich fraction (MPBAlk) of M. parvifolia was investigated on various animal models. MPBM extract and MPBAlk fraction when tested separately, showed statistically significant (P < 0.01) anti-inflammatory activity by inhibition of percentage rise in paw edema as compared to the control group in a dose dependent manner at different time intervals. When evaluated in acetic acidâinduced writings, hot plate and tail flick method in mice, MPBM extract and...

Hepatoprotective and Antioxidant Effects of Stereospermum suaveolens on Carbon Tetrachloride-Induced Hepatic Damage in Rats

Journal of Complementary and Integrative Medicine — Fri, 02 Jul 2010 16:23:17 +0100

The ethanol extract of Stereospermum suaveolens (EESS) bark was evaluated for its hepatoprotective and antioxidant activities against carbon tetrachloride (CCl4)-induced liver damage, in wistar albino rats. The ethanol extract of Sterespermum suaveolens (EESS) bark (200 and 400 mg/kg body weight, p.o.) was administered to the experimental rats for 14 days. Silymarin (50 mg/kg body weight (b.w.) was given as the standard drug. The hepatoprotective activity was assessed using various serum biochemical parameters as glutamate oxaloacetate transaminase (SGOT), glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), bilirubin, and total proteins. Malondialdehyde (MDA) level as well as the activities of superoxide dismutase (SOD), reduced glutathione (GSH) and catalase (CAT) were det...

Estrogenic and Embryo-Fetotoxic Effects of Ethanol Extract of Linum usitatissimum in Rats

Journal of Complementary and Integrative Medicine — Mon, 21 Jun 2010 20:39:39 +0100

The objective of the study was to investigate estrogenic and progestogenic activity of ethanol extract of Linum usitatissimum (LU-EE) in immature rats and its resultant effect on pregnancy in adult rats. Estrogenic activity was carried out by vaginal cornification, vaginal opening and by rodent uterotrophic assay. Effect of LU-EE on pregnancy in rats was studied on female Wistar rats by oral administration of LU-EE to pregnant female rats from day 1-7 of pregnancy. Further progesterogenic activity was studied by histamine-induced deciduoma formation. Blood hormones were estimated for further confirmation. LU-EE (500, 1000 mg/kg) caused a significantly (P (Source: Journal of Complementary and Integrative Medicine)

Why Seek Complementary Medicine? An Observational Study in Homeopathic, Acupunctural, Naturopathic and Mainstream Medical Practice

Journal of Complementary and Integrative Medicine — Wed, 09 Jun 2010 16:40:26 +0100

There is a steady increase in patients seeking complementary medicine (CM). Little is known about Dutch CM patients and the extent in which they differ from those of mainstream health care seekers. 1839 consecutive new patients consulting one of 40 CM physicians completed a questionnaire before entering the consulting room. Resulting CM patient data was compared with that from 2784 mainstream general practice patients. Differences in patient profiles were tested using multilevel regression analysis. CM patients most often appeared to report general complaints. Half of them consulted a CM physician because they were looking for information and advice from a different angle. One fifth had doubts about mainstream healthcare. The CM patients foremost expected to be treated as a person and to g...

Anxiolytic Activity of Canscora decussata in Albino Rats

Journal of Complementary and Integrative Medicine — Tue, 08 Jun 2010 19:35:02 +0100

Shankhpushpi is a popular medicinal plant in the Ayurvedic system of medicine for treating mental disorders. The present study was undertaken to investigate the effects of Canscora decussata Schult. (Gentianaceae) commonly known as shankhpushpi on the central nervous system of albino rats. Ethanolic extract of the aerial parts of the plant was evaluated in the elevated plus-maze test, open field exploratory behavior and rotarod performance experiments. In the elevated plus-maze, ethanolic extract at a dose of 100, 200 and 400 mg/kg p.o. showed an anxiolytic effect as evidenced by increase in the time spent in open arms and the number of open arm entries, compared to control group. The open field exploratory behaviour was also increased on administration of the ethanolic extract. The ethano...

Possible Applications of Psychotherapy Outcome Research to Traditional Chinese Medicine

Journal of Complementary and Integrative Medicine — Tue, 08 Jun 2010 10:58:34 +0100

This paper proposes that psychotherapy has affinities with TCM that may be useful for our understanding of both. These affinities center on the way in which the doctor/patient relationship is viewed and the ways in which treatment is understood. Based on affinities between psychotherapy and TCM the paper further proposes that psychotherapy outcome studies may be applicable to TCM and enhance TCM research and practice. Psychotherapy outcome research studies have consistently demonstrated the significance of common factors associated with the therapeutic alliance in predicting outcomes rather than factors related to therapeutic models or strategies per se. (Source: Journal of Complementary and Integrative Medicine)

Genotoxic Assessment of Pterocarpus marsupium Extract

Journal of Complementary and Integrative Medicine — Mon, 07 Jun 2010 23:58:38 +0100

Pterocarpus marsupium is a deciduous tree native to India, Nepal and SriLanka. Various portions of the bark are used as astringent, anti-diarrheal, antacid, for treatment of toothache and for management of diabetes. We have demonstrated strong antioxidant activity of this extract using different biochemical assays. Since this extract is being used as antidiabetic agent for a longer duration, studies were undertaken to evaluate the genotoxicity of this extract if any using both somatic cells and germ cells. Results obtained clearly demonstrate that the extract by itself is not genotoxic. Additionally it reduced the genotoxic effect of cyclophosphamide in a dose dependent manner which was comparable to a known antimutagen, vitamin C. Thus this data clearly demonstrates that there are no geno...

HERBAVATE an Alternative Approach for the Management of Eczema?

Journal of Complementary and Integrative Medicine — Wed, 02 Jun 2010 05:08:51 +0100

HERBAVATE is a topical preparation that contains the oil extracts of Calotropis gigantea, Curcuma longa, Pongamia glabra & Solanum xanthocarpum in a cream base. The present study is a pilot study evaluating the efficacy and safety of HERBAVATE in the management of eczema. 37 out-patients with a clinical diagnosis of eczema were enrolled in an open label study carried out at 2 centers. Patients applied HERBAVATE cream over the lesion twice daily and were followed up weekly for 4 weeks. Patients were assessed weekly on a 4 point scale for the severity of symptoms associated with eczema, viz. erythema, scaling, lichenification and pruritis. Local tolerance was assessed on a 4 point scale. All analysis were carried out on 32 patients, there were 5 dropouts. At the end of the study there was a ...

Modulatory Effect of Psidium Guajava Linn and Ocimum Gratissimum Linn on Lipid Profile and Selected Biochemical Indices in Rabbits Fed High Cholesterol Diet

Journal of Complementary and Integrative Medicine — Wed, 14 Apr 2010 23:47:36 +0100

The effect of aqueous leaf extracts of Psidium guajava(PG) and Ocimum gratissimum(OG) on fasting plasma glucose (FPG), total protein (TP), albumin (ALB), globulin (GLB), total cholesterol (TC), triglyceride (TG), HDL-cholesterol (HDL), LDL-cholesterol (LDL) and lactate dehydrogenase (LDH) concentrations in rabbits fed high-cholesterol diet was investigated. Four groups of animals were used (n = 6). Animals in group A were fed normal laboratory pellet and water ad libitum; those in group B were fed the high-cholesterol diet (normal diet + 1% w/w cholesterol + 1% w/w vegetable oil) while those in groups C and D received a daily oral administration of 250 mg/kg body weight of the extract of Psidium guajava and Ocimum gratissimum, respectively, in addition to the high-cholesterol diet for a pe...

Protective Effect of Dendrobium officinale Polysaccharides on Experimental Sjogren's Syndrome

Journal of Complementary and Integrative Medicine — Sat, 10 Apr 2010 00:33:54 +0100

Sjogren's syndrome (SS), usually described as a chronic inflammation which results in xerostomia (dry mouth) and xerophthalmia (dry eyes). According to the theory of traditional Chinese medicine, body fluid impairment causes the dryness, inducing water secretion deficiency. Discovery of a family of water-specific membrane channel proteins, the aquaporins, provides an interesting molecular mechanism of water permeability and transportation which were found abnormal in tissues of SS patients. Thus, this dryness may lead to the dysfunction in organs as various systematic manifestations. We established an autoallergic mouse model in vivo, and human salivary gland cell line A-253 in vitro. Polysaccharides of Dendrobium officinale (DP) were administrated as treatment, which was described to nour...

Effect of Tephrosia purpurea (L) Pers. on Partial Thickness and Full Thickness Burn Wounds in Rats

Journal of Complementary and Integrative Medicine — Wed, 07 Apr 2010 18:13:07 +0100

The objective of the present study was to screen the flavonoid-rich fraction of Tephrosia purpurea L. aerial parts for its burn wound repairing efficacy based on traditional uses. Flavonoid fraction ointment (5% w/w) was prepared with simple ointment base B.P. for topical application. The silver sulphadiazine ointment (standard) and simple ointment base B.P. (control) was used in partial thickness and full thickness burn wound models. Wound contraction and tensile strength were measured in partial thickness burn, where as full thickness model was used for the determination of protein, hydroxyproline, anti-oxidant enzymes (SOD, CAT and GSH) level in granuloma mass as well as for histopathological study. It was observed that, wound contraction and tensile strength of skin tissues were observ...

Anti-Nociceptive and Locomotor Activity of Zanthoxylum nitidum Stem Bark Extracts in Experimental Animal Models

Journal of Complementary and Integrative Medicine — Wed, 07 Apr 2010 18:13:03 +0100

Conclusion: Present investigation demonstrates that the stem bark extracts of Z. nitidum exhibited remarkable anti-nociceptive and depressed locomotor activity in mice. (Source: Journal of Complementary and Integrative Medicine)

Anti-Urolithiatic Activity of Heart Wood Extract of Cedrus deodara in Rats

Journal of Complementary and Integrative Medicine — Wed, 07 Apr 2010 18:12:58 +0100

The petroleum ether extract of the heart wood of Cedrus deodara (PECD) was tested for its diuretic and anti-urolithiatic activity. The urolithiasis was experimentally induced by administering sodium oxalate (70 mg/kg, i.p) for 10 days. PECD (100 and 200 mg/kg) was orally gavaged daily 1 h before sodium oxalate (NaOx) administration for 10 days. In NaOx treated rats, crystal was observed in urine under light microscope and elevation of serum parameters indicated the development of nephrolithiasis in the control group. Concomitant administration of PECD for 10 days along with NaOx prevented elevated serum biochemical levels due to the elimination of these in urine. Histology of the kidneys also indicated that PECD treatment had protected against NaOx induced nephroliathiasis. These results o...

Inhibition of Cytokine Expression and Prostaglandin E2 Production in Monocyte/Macrophage-Like Cells by Avocado/Soybean Unsaponifiables and Chondroitin Sulfate

Journal of Complementary and Integrative Medicine — Fri, 12 Mar 2010 21:34:47 +0100

Osteoarthritis is characterized by inflammation and increased production of pro-inflammatory mediators including cytokines and prostaglandin E2 (PGE2). Macrophage-like cells in synovial tissue produce these mediators which induce degradative enzymes that break down cartilage. We determined whether avocado/soybean unsaponifiables (ASU) and chondroitin sulfate (CS) can inhibit cytokine expression and PGE2 production using monocyte/macrophage-like cell models. Cells were incubated for 24 hours with either control media alone, ASU alone (NMX1000; 8.3 μg/ml), CS alone (TRH122; 20 μg/ml), or a combination of both preparations. Cells were activated with cytokines or lipopolysaccharide for 1 or 24 hours to determine cytokine gene expression by RT-PCR and PGE2 production by immunoassay, respectiv...

Central Nervous System Activity of Acute Administration of Latex Proteins from Calotropis procera in Mice

Journal of Complementary and Integrative Medicine — Fri, 12 Mar 2010 21:34:40 +0100

Relevant properties have been detected in protein fraction (LP) isolated from latex of Calotropis procera. In order to best characterize LP potentiality, this work describes some effects of LP on central nervous system (CNS). Three models were performed: elevated plus maze (EPM), open field (OF), and hole-board (HB) tests. LP was administered intraperitoneally to male mice. To assess the probable action mechanism, drugs acting on glutamatergic (ketamine, i.p.), gabaergic (diazepam and flumazenil, i.p.) and dopaminergic (haloperidol, i.p.) systems were used on OF. Decreases in the number of entries in the open and closed arms of EPM were observed at 100 mg/kg and this effect may be due to the reduction in the locomotor activity previously observed. A reduction in locomotor activity was obse...

Optimized St. John's Wort (Hypericum perforatum L.) Germplasm Lines Exert Cytotoxicity in HT-29 Colon Cancer Cells via Downregulation of NF-κB

Journal of Complementary and Integrative Medicine — Mon, 08 Mar 2010 20:55:35 +0100

Extracts of two germplasm lines of St. John's wort (SJW; Hypericum perforatum L.) selected for enhanced hypericin and hyperforin content were evaluated for potential activity against colon cancer. Bioactivity was assessed in signaling pathways of tumor necrosis factor-a (TNF-α) and nuclear transcription factor-κB (NF-κB) in HT-29 colon cancer cells. Both extracts and the hypericin standard significantly inhibited growth of HT-29 cells. Levels of active NF-κB were reduced in cells treated with either of the plant extracts or hypericin, but the purified hyperforin standard was comparatively ineffective. The combination of TNF-α and SJW treatments had significantly higher cytotoxic effects, and reduced the expression of NF-κB, inhibitor of NF-κBs (IκBa), IκB kinase b (IKKb), and TNF ...

Inhibitory Effect of Seabuckthorn (Hippophea rhamnoides) on Platelet Aggregation and Oxidative Stress

Journal of Complementary and Integrative Medicine — Mon, 08 Mar 2010 20:53:25 +0100

Extracts from seabuckthorn (Hippophea rhamnoides) leaves, fruit and seed oil were screened for anti-platelet properties in-vitro using human platelets stimulated with 0.2 mM ADP. Half maximal inhibitory concentration was found to be 55 microg/ml platelet rich plasma(PRP) for leaf extract, 47.7 microg/ml PRP for fruit extract and 0.62 microl/ml PRP for seed oil. In-vitro incubation of platelets with increasing concentrations of seed oil was found to inhibit oxidative stress in resting as well as agonist stimulated platelets as evident by decreased formation of peroxide and superoxide radicals. Leaf extract and seed oil were further evaluated for antiplatelet and antioxidant action in-vivo in cholesterol-induced experimental atherosclerosis in rabbits. Rabbits fed on diet supplemented with c...

Thai Yoga as an Appropriate Alternative Physical Activity for Older Adults

Journal of Complementary and Integrative Medicine — Wed, 03 Mar 2010 19:35:38 +0100

Thai Yoga (TY), has been recommended by the Public Health Ministry of Thailand for keeping people fit. There is little known about the physiological demand it places on those practicing it. Therefore, the purpose of this study is to determine i) the exercise intensity of TY indicating by both absolute intensity (i.e. MET) and relative intensity (i.e. percentage of maximal oxygen consumption (VO2,max) and heart rate (HRmax)) and ii) the impact it has on the cardiovascular system and energy expenditure. Fourteen healthy adults ranging in age from 50 to 65 years performed 30-minute TY and exhaustive cycling exercise (to indicate maximal oxygen consumption) sessions one week apart. Mean of MET and the percentage of mean of VO2 and HR during TY to VO2,max and HRmax were found to be 1.51±0.43 M...

The Antioxidant, Iron Chelating and DNA Protective Properties of 70% Methanolic Extract of 'Katha' (Heartwood extract of Acacia catechu)

Journal of Complementary and Integrative Medicine — Mon, 01 Mar 2010 23:45:20 +0100

The present study was carried out to determine the antioxidant and iron chelating property of 70% methanolic extract of 'katha' (heartwood extract of Acacia catechu). The extract was found to be an antioxidant with a TEAC value of 0.72 ± 0.02. The extract has shown its scavenging activity for different radical and 17.8 ± 0.63 μg/ml, 39.55 ± 1.36 μg/ml, 55.31 ± 7.12 μg/ml, 746.85 ± 30.46 μg/ml, 44.2 ± 4.48 mg/ml, 57.5 ± 4.23 μg/ml, 155.48 ± 3.78 μg/ml were determined as IC50 value for DPPH, superoxide, nitric oxide, peroxynitrite, hydrogen peroxide, singlet oxygen and hypochlorous acid radicals, respectively. The plant was found to inhibit lipid peroxidation with an IC50 of 12.35 ± 0.43 μg/ml. The extract also has the ability to chelate iron with an IC50 of 810.8 ± 20.74 μ...

In Vitro Antioxidant and In Vivo Antihyperglycemic Potential of Mimusops elengi L. in Alloxan-Induced Diabetes in Mice

Journal of Complementary and Integrative Medicine — Tue, 23 Feb 2010 23:54:29 +0100

Mimusops elengi, commonly called 'Bakul' is a medicinally important plant of family sapotaceae. All parts of the tree have medicinal properties. Sushrut Samhita in the Chikitsa chapter explains the treatment strategies for the diabetes. Mimusops elengi (ME) is endowed with the antidiabetic potential. The present study was aimed to evaluate the in vitro antioxidant and antihyperglycemic property of ME. Aqueous extract of ME (MEAQE) exhibited reducing power as well as DPPH and OH radical scavenging activity in vitro. It can be concluded from above observation that the onset of action of antihyperglycemic activity of MEAQE is at the 2nd hr and duration of action is before the 24th hr. in alloxan-induced diabetes. MEAQE may act by increasing peripheral utilization of glucose. Taking into consi...

A Red Wine Extract Supplement Protects against Apoptosis and Inhibits Changes in Mitochondrial Permeability and Membrane Potential

Journal of Complementary and Integrative Medicine — Tue, 23 Feb 2010 21:53:24 +0100

The effects of a red wine extract supplement (Super S.O.D) on hypoxia/reoxygenation-induced apoptosis were examined in H9c2 cardiomyocytes. Super S.O.D pretreatment dose-dependently protected against hypoxia/reoxygenation-induced apoptosis in H9c2 cardiomyocytes. The cytoprotection was associated with increases in cellular reduced glutathione level and mitochondrial membrane potential, as well as the decrease in the extent of Ca2+-induced mitochondrial permeability transition (MPT) pore opening in both unchallenged and challenged cells, as compared with the unpretreated control. The results indicated that Super S.O.D pretreatment protected against hypoxia/reoxygenation-induced apoptosis in H9c2 cardiomyocytes, possibly mediated by the inhibition of MPT triggered by hypoxia/reoxygenation ch...

Antihyperglycaemic Properties of the Ethyl acetate Extract of Dennettia tripetala in Diabetic Rats

Journal of Complementary and Integrative Medicine — Tue, 23 Feb 2010 21:53:21 +0100

Antihyperglycemic properties of chloroform (CDT), ethyl acetate (EDT) and methanolic (MDT) extracts of D. tripetala were investigated using alloxan- and streptozotocin-induced hyperglycemic rats. An oral glucose tolerance test (OGTT) was performed in EDT-pretreated in both normal and alloxan-induced hyperglycemic rats. Tolbutamide (TLB) was used as the reference drug. TLB (100 mg/g), EDT (100 mg/kg), MDT (100 mg/kg) significantly (p (Source: Journal of Complementary and Integrative Medicine)

Acute and Sub Chronic Oral Toxicity of Sida rhomboidea.Roxb Leaf Extract

Journal of Complementary and Integrative Medicine — Tue, 23 Feb 2010 21:53:17 +0100

Acute and sub chronic oral administration of Sida rhomboidea.Roxb (SR) aqueous leaf extract did not register any adverse behavioral alterations or significant toxic manifestations. However, significant decrement in food intake and body weight gain along with higher plasma AST and ALT levels were recorded with a dose of 3000 mg/kg body weight. It is inferred that SR extract is non-toxic, therefore, safe for consumption. (Source: Journal of Complementary and Integrative Medicine)

Hepatoprotective Evaluation of Scoparia dulcis L.

Journal of Complementary and Integrative Medicine — Wed, 30 Dec 2009 23:55:42 +0100

Scoparia dulcis L. (Family: Scrophulariaceae) is an herb native to America and in tropics and widely present in Karnataka, India. This plant has been traditionally used to cure many liver aliments. Phytochemical screening has revealed that the plant contains diterpenoids, flavonoids, tannins, alkaloids, triterpenes, hexacosonol, β-sitosterol, ketone, dulcitone and amellin. Liver cirrhosis represents the common pathological outcome for the majority of chronic liver insults (e.g. alcohol, autoimmune, or viral injury, even oxidative stress). The therapeutic potential of antioxidants with respect to liver toxicity has been realized marginally so far. In the present study the in vitro antioxidant activity and antihepatotoxic activity of hydroalcoholic extract of S. dulcis (HASD) was investigat...

Augmentation of Antioxidant Defense System by Tinospora cordifolia: Implications in Radiation Protection

Journal of Complementary and Integrative Medicine — Tue, 15 Dec 2009 23:47:01 +0100

Conclusion: These results imply that RTp treatment augmented antioxidant defense system which afforded an important mechanism of radioprotection. The bio-molecules present in RTp acting in this direction need to be investigated further. (Source: Journal of Complementary and Integrative Medicine)

Determination of Phenolic Content of Cassia sophera Linn. and the Potential Antiulcer Activity in Experimentally Induced Ulceration

Journal of Complementary and Integrative Medicine — Fri, 11 Dec 2009 00:48:09 +0100

Cassia sophera is a medicinally important plant belonging to the family Caesalpiniaceae. It is being used in the ailments of oxidative stress. Cassia sophera was successively extracted with chloroform (CSE1), ethyl acetate (CSE2), methanol (CSE3) and water (CSE4). Extracts demonstrated the presence of anthraquinones and flavonoids. Amongst all of the extracts, CSE2 exhibited highest total phenolic content (250.54 mg/gm) as well as antiulcer potential using ethanol, pyloric ligation, hypothermic restrain stress and indomethacin-induced ulceration. Cassia sophera presented protection against ulceration, which may be because of both cytoprotective and antisecretary mechanisms. The phenolic content could be responsible for the gastro protective activity of CS. (Source: Journal of Complementary...

Globularia alypum L. Lyophilized Methanolic Extract Decreases Hyperglycemia and Improves Antioxidant Status in Various Tissues of Streptozotocin-Induced Diabetic Rats

Journal of Complementary and Integrative Medicine — Thu, 03 Dec 2009 06:21:24 +0100

The purpose of the present study was to investigate the antihyperglycemic and antioxidant effects of Globularia alypum (Ga) methanolic extract in streptozotocin-induced diabetic rats (50 mg/kg, i.p.). Twenty diabetic rats were divided into two groups; one group was fed a casein diet supplemented with Ga extract (1 g/kg body weight), for 4 weeks, and the other group went untreated. In Ga-treated compared to untreated rats, glycemia and HbA1c values were respectively 5.2- and 3.6-fold lower. Plasma total cholesterol, triacyglycerols levels and transaminases activities were decreased significantly (P (Source: Journal of Complementary and Integrative Medicine)

Complementary or Alternative--Does It Matter In Your Questionnaire?

Journal of Complementary and Integrative Medicine — Fri, 09 Oct 2009 15:11:21 +0100

In this study the impact of the use of the terms complementary medicine and alternative medicine on participants' responses to surveys about the use of, and beliefs about, these therapies was explored. Two identical surveys were prepared, one of which referred to alternative medicines and the other which referred to complementary medicine. A telephone survey was used to gather responses from a random sample of individuals living in 3 geographically close metropolitan cities in Australia. Respondents were those aged over 18 years who consented to participate in the study. Forty five percent of respondents indicated using complementary medicines while 34% used alternative medicine; similarly 40% had visited a complementary medicine practitioner while 29% had visited an alternative medicine p...

Effects of R-Alpha Lipoic Acid on HbA1c, Lipids and Blood Pressure in Type-2 Diabetics: A Preliminary Study

Journal of Complementary and Integrative Medicine — Wed, 07 Oct 2009 00:13:22 +0100

Conclusions: Three months of R-ALA supplementation may lower HbA1c in a small number of individuals. However, to further confirm these findings, larger studies of longer duration are needed. (Source: Journal of Complementary and Integrative Medicine)

Augmentation of Mind-body Therapy and Role of Deep Slow Breathing

Journal of Complementary and Integrative Medicine — Mon, 05 Oct 2009 15:39:47 +0100

This article overviews the role of slow rhythmic breathing in physiological as well as therapeutic effects of mind-body therapies. Slow deep breathing practice has important implications as it may underlie the basic mechanism that synchronizes the brain with the autonomic response. This article reviews studies that include the effect of deep slow breathing with or without mind-body therapy exercises. In utero studies that monitor patterns of fetal breathing reveal sympathetic activation with irregular, shallow fast breathing movements compared to slow deep breathing. Recognition of respiratory mechanisms in mind-body therapies can lead to development of more effective relaxation exercises that may incorporate deep slow breathing in clinical applications. (Source: Journal of Complementary a...

Static Electric Field by High Voltage Alternating Current Ameliorates Collagen-Induced Arthritis in Mice via the Inhibition of IL-1β Expression

Journal of Complementary and Integrative Medicine — Thu, 01 Oct 2009 23:50:04 +0100

Conclusion: Based on these data, the beneficial effects of EF-HVAC on a murine rheumatoid arthritis model may be attributed to its anti-inflammatory properties. (Source: Journal of Complementary and Integrative Medicine)

Effect of Citrullus colocynthis Schard on Testosterone-Induced Benign Prostatic Hyperplasia

Journal of Complementary and Integrative Medicine — Tue, 22 Sep 2009 00:02:21 +0100

The petroleum ether extract of Citrullus colocynthis Schrad (Cucurbitaceae) fruits and a steroidal compound isolated from this extract were tested in Wistar rats for their effect on Prostatic Hyperplasia (PH) induced by testosterone. The PH was induced in rats by daily subcutaneous injection of testosterone for 10 days. Rats of the test group were administered 100 mg/kg of petroleum ether extract of Citrullus colocynthis fruit along with testosterone. Graded doses i.e, 1, 2.5, and 5 mg/kg dose of isolated steroidal fraction were also tested in three groups of rats. Finasteride was used as positive control. Treatment with C. colocynthis extract reduced prostatic weights of the treated animals considerably. The isolated steroidal fraction also diminished the weight of prostate in dose depend...

Protective Role of Pterocarpus marsupium in Diabetes-Induced Hyperlipidemic Condition

Journal of Complementary and Integrative Medicine — Tue, 22 Sep 2009 00:02:17 +0100

In conclusion, our present results suggest hypolipidemic effect of P. marsupium in hyperglycemic condition. (Source: Journal of Complementary and Integrative Medicine)

Probable Mechanism of the Antihyperglycemic Effect of Standardized Extract from Momordica charantia in Streptozotocin Diabetic Rats

Journal of Complementary and Integrative Medicine — Wed, 16 Sep 2009 23:58:09 +0100

The herb Momordica charantia Linn has been used widely in India and other countries for the treatment of diabetes. In the present study reports the antihyperglycemic activity of standardised Momordica charantia extract (MCE) using in-vivo and in-vitro animal models along with the relevant biochemical and histopathological parameters. The antihyperglycemic activity of MCE was compared with that of glibenclamide, a known potent anti-diabetic drug. MCE treatment reduced blood glucose levels both in normal and streptozotocin (STZ)-induced diabetic rats, and also restored the glucose tolerance significantly in diabetic rats. MCE treatment enhanced glucose uptake process and increased liver glycogen. Furthermore, MCE treatment reduced the elevated serum lipids and glycosylated haemoglobin levels...

Caudal Epididymal Sperm Characteristics and Testicular Morphometrics of Rabbits Fed Graded Levels of a Blood-Wild Sunflower Leaf Meal (BWSLM) Mixture Diet

Journal of Complementary and Integrative Medicine — Mon, 14 Sep 2009 03:04:43 +0100

The effects of feeding graded levels of blood-wild sunflower leaf meal (BWSLM) mixture on rabbit caudal epididymal sperm characteristics and testicular morphometrics were investigated. The BWSLM mixture was included in the feed at 0, 5, 10 and 15% levels in diets 1, 2, 3 and 4, respectively. The motile-spermatozoa for diet 3, which was 77%, was significantly (P (Source: Journal of Complementary and Integrative Medicine)

Antiproliferative, Antioxidant and Cyto/DNA Protective Properties in Andrographis serpyllifolia: Role of Andrographolide and Phenolic Acids

Journal of Complementary and Integrative Medicine — Wed, 09 Sep 2009 18:16:28 +0100

Among several Andrographis species, only A. panniculata had been extensively studied and the bioactivity was attributed to the active component - Andrographolide (AG). In the current investigation, we report that aqueous (ASAE) and methanol (ASME) extracts of Andrographis serpyllifolia contained phenolic acids up to 3-5%, in addition to AG which is present at ~2% level. Aqueous extract exhibited ~2 and 10 fold better free radical scavenging and reducing power activities than those of methanol extract and the isolated andrographolide, suggesting that Andrographis species may contain antioxidant components other than Andrographolide as well. Further, about 70-80% of DNA and red blood cells were protected against oxidant-induced damages at 4 μg/mL, and there was about 80% inhibition of prol...

Assessment of in Vitro Antioxidant and Free Radical Scavenging Activity of Cajanus cajan

Journal of Complementary and Integrative Medicine — Wed, 09 Sep 2009 18:09:46 +0100

The present study was undertaken to evaluate the antioxidant and free radical scavenging activities of 70% methanolic extract of Cajanus cajan leaves using various in vitro assays. The TEAC value 0.84 ± 0.05 for the extract indicates it is an antioxidant. The extract had shown its scavenging activity for different free radicals and 175.73 ± 7.50 μg/ml, 27.17 ± 0.9 μg/ml, 60.78 ± 5.15 μg/ml and 250.29 ± 5.70 μg/ml were determined as the IC50 values for hydroxyl, superoxide, nitric oxide and singlet oxygen radicals, respectively. The sample showed reasonable chelation of Fe2+ ion and inhibition of lipid peroxidation. The phenolic and flavonoid contents of the extract were also determined to be 51.33 ± 0.002 mg/ml gallic acid equivalent and 143.0 ± 0.003 mg/ml quercetin equivalent,...

Exposure to Oscillating High Electrical Potential and the Associated Low Frequency Magnetic Field Enhances the Hepatoprotective Action of Schisandrin B in Vivo and in Vitro

Journal of Complementary and Integrative Medicine — Mon, 31 Aug 2009 20:38:30 +0100

The effect of electromagnetic manipulation (EM), consisting of an oscillating (50 Hz) high electrical potential (a maximum value of 20,000 V and an output current < 100 µA) and its associated alternating magnetic field (50-60 Guass), on the hepatoprotective action of schisandrin B (Sch B, an active ingredient isolated from the fruit of Schisandra chinensis) was examined in the mouse model of carbon tetrachloride (CCl4) hepatotoxicity and the AML12 cell model of menadione-induced toxicity. EM was found to enhance the Sch B-induced hepatoprotective action against CCl4 toxicity in mice and cytoprotective action against menadione toxicity in AML12 hepatocytes. The potentiating effect of EM on the pharmacological action of Sch B may be mediated by the increase in drug availability to tissues o...

Effect on Inhibition of Proliferation and Antioxidant Enzyme Level of Lippia nodiflora in EAC Cell Line Treated Mice

Journal of Complementary and Integrative Medicine — Thu, 13 Aug 2009 16:09:59 +0100

Conclusion: The results of the present study suggest that MELN exhibited significant antitumor activity may be due to the increase of antioxidant activity in EAC bearing mice. (Source: Journal of Complementary and Integrative Medicine)

Protective Effect of Red Wine Extract Supplement against Myocardial Ischemia/Reperfusion Injury in Rats: Effects on Mitochondrial Antioxidant and Structural Parameters

Journal of Complementary and Integrative Medicine — Thu, 13 Aug 2009 16:05:37 +0100

Reperfusion of the previously ischemic myocardium causes a burst of reactive oxygen species production that eventually leads to tissue damage. In the present study, the effect of long-term treatment with a red wine extract-containing antioxidant supplement (Super S.O.D) on myocardial ischemia/reperfusion (I/R) injury was examined in rats. To investigate the biochemical mechanism(s) involved in the cardioprotection, the effects of Super S.O.D treatment on myocardial mitochondrial antioxidant and structural parameters were also investigated. Long-term treatment with Super S.O.D (0.55 and 1.10 g/kg/day x 15) caused a dose-dependent protection against myocardial I/R injury in rats, as evidenced by the significant decrease in the extent of lactate dehydrogenase leakage. The cardioprotection was...

Anti-Nociceptive and Anti-Inflammatory Activities of Extracts from the Stem Bark of Croton macrostachyus (Euphorbiaceae) in Mice and Rats

Journal of Complementary and Integrative Medicine — Tue, 28 Jul 2009 02:42:20 +0100

The present study evaluates the anti-nociceptive and anti-inflammatory properties of the aqueous and methylene chloride/methanol (CH2Cl2 / CH3OH) extracts of the stem bark of Croton macrostachyus. The extracts administered orally at the doses of 150, 300 and 600 mg/kg were examined against pain induced by acetic acid, formalin and pressure and against inflammation induced by carragenan, histamine and formalin. Both extracts induced a significant dose-dependent (P < 0.001) reduction in the number of abdominal constrictions induced by acetic acid. The three doses of the two extracts also significantly reduced (P < 0.001) the two phases of pain induced by formalin. At the dose of 600 mg/kg, the aqueous and the CH2Cl2 / CH3OH extracts exhibited a significant analgesic activity against pressure...

Phytochemical Constituents and Free Radical Scavenging Activity of Clerodendron glandulosum.Coleb Methanolic Extract

Journal of Complementary and Integrative Medicine — Fri, 10 Jul 2009 23:46:01 +0100

Conclusion: The results suggest that a methanolic extract of Clerodendron glandulosum.Coleb possesses a strong antioxidant activity against all known radicals and can be considered as a natural antioxidant. (Source: Journal of Complementary and Integrative Medicine)

Antidiarrhoeal Activity of Pterocarpus santalinoides L'Hérit ex DC Leaf Extract

Journal of Complementary and Integrative Medicine — Wed, 24 Jun 2009 23:48:42 +0100

In this study we investigated the methylene chloride-methanol leaf extract of Pterocarpus santalinoides (PSE), a plant believed to possess potent antidiarrhoeal properties in folk medical practice. The antidiarrhoeal and anti-enteropooling activity of PSE were investigated in castor oil induced diarrhoea in rats. The effect on gastrointestinal motility was studied by the charcoal meal transit in mice. Smooth muscle activity of the extract was investigated in isolated guinea pig ileum. P. santalinoides extract (100-500 µg/ml) caused a significant and dose-related inhibition of the frequency of diarrhoeic drops in rats (P< 0.05) and prolonged the time for diarrhoea induction. The extract also exhibited significant anti-enteropooling activity (P (Source: Journal of Complementary and Integrat...

Is All Glucosamine Alike? Clarifying the Controversies for Product Selection and Clinical Research

Journal of Complementary and Integrative Medicine — Tue, 23 Jun 2009 19:42:18 +0100

In the United States, glucosamine is marketed as a dietary supplement therefore subject to less stringent manufacturing, labeling and marketing regulations than pharmaceuticals. The glucosamine product selected for the NIH-sponsored Glucosamine/chondroitin Arthritis Intervention Trial (GAIT) was required to satisfy Investigational New Drug (IND) application (and therefore pharmaceutical manufacturing requirements). This review describes the procedure that was developed by the authors to identify a high-quality glucosamine product for GAIT and to clarify confusing product information and nomenclature.Proprietary glucosamine products and bulk glucosamine powders of various salt forms were evaluated. Both the published literature and information provided by suppliers of bulk glucosamine powd...

A Review of Side Effects and Adverse Events of Non-Drug Medicine (Nonpharmaceutical Complementary and Alternative Medicine): Psychotherapy, Mind-Body Medicine and Clinical Holistic Medicine

Journal of Complementary and Integrative Medicine — Tue, 12 May 2009 22:05:58 +0100

Conclusions: Non-drug (non-pharmaceutical) medicine seems to be safe even for seriously physically and mentally ill patients and, whenever efficient, therefore recommended as treatment of choice. (Source: Journal of Complementary and Integrative Medicine)

Using the Biopsychosocial Model to Understand the Health Benefits of Yoga

Journal of Complementary and Integrative Medicine — Wed, 29 Apr 2009 01:58:43 +0100

We present empirical evidence that supports the involvement of these domains. However, additional well-conducted research is required to further establish the efficacy of yoga for health states, and to understand how posture, breath and meditative activity affect the body, mind and spirit. (Source: Journal of Complementary and Integrative Medicine)

The Effect of Tai Chi in Reducing Anxiety in an Ambulatory Population

Journal of Complementary and Integrative Medicine — Wed, 29 Apr 2009 01:53:20 +0100

Tai Chi is an ancient Chinese art that has been practiced for centuries. This mind-body exercise is a standard of medical care in many Asian countries. The Western world lags behind in the study of alternative medical treatments. This pilot study utilized Tai Chi to relieve anxiety in a population diagnosed with moderate-severe anxiety. This diagnosis was made by clinicians utilizing the well-respected Hamilton-Anxiety psychiatric rating scale. This non-pharmacologic method for reduction of anxiety was chosen because medications presently utilized for anxiety often cause untoward side effects. Subjects were recruited throughout the community. Patients completed a health questionnaire and were screened by a psychiatrist before and after participating in a 10-week program of Tai Chi classes ...

Methodological Issues Pertaining to the Evaluation of the Effectiveness of Energy-Based Therapies, Avenues for a Methodological Guide

Journal of Complementary and Integrative Medicine — Wed, 29 Apr 2009 01:49:55 +0100

The current interest in Complementary and Alternative Medicine (CAM) begs the question of their integration into the health care system, which will most likely require rigorous scientific evaluation in randomized controlled trials (RCT) before they are fully accepted and integrated. Although some meta-analyses demonstrate the potential of certain energy-based (EB) CAM therapies others highlight significant methodological weaknesses in the study design. It is not only important to verify the effectiveness of energy-based therapies (EBT), but also to do it with methods that are appropriate to the evaluation of this type of therapy. In fact, there are those who question the applicability of traditional research models to the evaluation of CAM therapies. It is with this in mind that we wish to...

In Vitro Evaluation of Antioxidant and Free Radical Scavenging Activities of Rhodiola imbricata

Journal of Complementary and Integrative Medicine — Tue, 28 Apr 2009 23:35:49 +0100

The present study was undertaken to evaluate the in vitro antioxidant activities of aqueous extract of Rhodiola imbricata rhizome. The plant extract was evaluated for DPPH (1,1-diphenyl, 2-picryl hydrazyl) radical scavenging, superoxide anion radical scavenging, hydrogen peroxide scavenging, anti-lipid peroxidation assay, metal chelating activity, reducing power and total flavonoid content. Rhodiola imbricata aqueous extract (RIAE) exhibited more DPPH scavenging potential with IC50 value of 5.56 µg/ml as compared to standard butylated hydroxytoluene (BHT) (IC50 = 5.74 µg/ml). The extract also provided superoxide anion radicals' scavenging (IC50 = 4.68 vs 4.63 µg/ml) and anti-lipid per-oxidation activity (IC50 = 5.06 vs 4.91 µg/ml) and IC50 value was comparable to standard α-tocopherol...

Biphasic Modulation of Neutrophil Migration by Aqueous Extracts of Uncaria tomentosa in Murine Lung

Journal of Complementary and Integrative Medicine — Fri, 24 Apr 2009 16:47:43 +0100

In the history of medicine, the treatment of disease has been influenced by an intimate contact with nature. A mice model of lipopolysaccharide (LPS)-induced acute lung injury was used to evaluate the protective effects of long-term water-soluble administration ad libitum of Uncaria tomentosa extracts (20 gr/L; UTE) in lung inflammation. Swiss mice had LPS (1,67µg/ml) instilled intranasally 3hs before sacrificed, and were then pre-treated with UTE for 7, 15, 30 or 90 days or with a single dose of dexamethasone (2,5 mg/kg, DX). Inflammatory cell concentration was measured in the bronchoalveolar fluid (BALF) and histology was performed. No acute or chronic toxicity signs were observed in the clinical status. In addition, body weight, food consumption, organ weight, kidney, liver, and lung p...

Ameliorative Role of Vitamin E on Adverse Impact of Azadirachta indica in Reproductive Indices of Male Rats

Journal of Complementary and Integrative Medicine — Fri, 17 Apr 2009 03:21:12 +0100

This study was undertaken to determine the role of vitamin E on reproductive activity of Azadirachta indica extract in rats. Forty adult male albino rats were divided into 5 equal groups. The control group received distilled water while the other groups were treated with Azadirachta indica (150mg/kg bwt) extract alone, vitamin E (100mg/kg bwt) alone, combined Azadirachta indica (150mg/kg bwt) and vitamin E (100mg/kg bwt), and combined Azadirachta indica (150 mg/kg bwt) and vitamin E (150 mg/kg bwt). Group administered Azadirachta indica alone showed significant (p (Source: Journal of Complementary and Integrative Medicine)

Antibacterial Activity and Anticorrosive Efficiency of Aqueous Methanolic Extract of Artemisia pallens (Asteraceae) and Its Major Constituent

Journal of Complementary and Integrative Medicine — Mon, 13 Apr 2009 23:49:39 +0100

An aqueous-methanolic [methanol:water (1:1)] extract of the whole plant of Artemisia pallens (Family: Asteraceae) has shown good antibacterial activity against Pseudomonas aeruginosa and Shigella flexneri at the concentration of 100 mg/mL. The activity-guided fractionation has led to isolation of compound 4-hydroxyphenyl-β-D-glucopyranoside (which is known as arbutin), as a major constituent and exhibited the same antibacterial activity at a concentration of 17 mg/mL. Both the crude extract and arbutin also showed 94% anticorrosive efficiency against mild steel in 1M HCl at concentration of 200 mg/L. (Source: Journal of Complementary and Integrative Medicine)

Free Radical Scavenging Activity and Inhibitory response of Ziziphus mauritiana (Lamk.) Seed Extract on Alcohol-Induced Oxidative Stress

Journal of Complementary and Integrative Medicine — Mon, 13 Apr 2009 23:49:35 +0100

The antioxidant activity within the body has been well correlated with the body's defense mechanism against toxic free radicals. Alcohol ingestion increases the generation of free radicals. The present study was conducted to assess antioxidant potential of seed extract of Ziziphus mauritiana, which was standardized with HPLC. DPPH assay and Fenton reaction system was applied to assess free radical scavenging potential. The Swiss albino mice were used to evaluate the inhibitory activity of extract on oxidative stress induced by alcohol. The animals were treated with graded doses of extract (100-400 mg/kg body weight) before the administration of alcohol. After 6 weeks animals were sacrificed and their livers were assessed for catalase, superoxide dismutase, glutathione and lipid peroxidatio...

The Potential Role of Daucus carota Aqueous and Methanolic Extracts on Inflammation and Gastric Ulcers in Rats

Journal of Complementary and Integrative Medicine — Mon, 16 Mar 2009 23:43:19 +0100

Daucus carota (DC) is among commonly used plants in folk medicine in Lebanon and the region. The present investigation was undertaken to examine the effects of the aqueous and extracts of Daucus carota umbels against acute and chronic inflammation, gastric ulcer and antibacterial activity on rats. The effects of DC aqueous extract (DCAE) on glycemia, lipemia, hepatic, renal and pancreatic function were also examined. Results on acute inflammation showed that the aqueous and methanolic extracts (DCME) produced maximum anti-inflammatory activity at doses of 400 and 140 mg/kg body weight with 90.9 and 58.6 % inhibition, respectively. In chronic inflammation, the same doses showed maximum anti-inflammatory activity with 58 and 44.1 % inhibition, respectively. DCME showed significant protection...

Exploring Antidiabetic Mechanisms of Action of Galactomannan: A Carbohydrate Isolated from Fenugreek Seeds

Journal of Complementary and Integrative Medicine — Mon, 09 Mar 2009 16:49:48 +0100

The previously studied hypoglycemic effect of fenugreek galactomannan was confirmed in normal rats. Additional investigations were carried out to study the effect of galactomannan on utilization of glucose by hemidiaphragm and its antioxidant activity in diabetic rats. As compared to diabetic control rats, the galactomannan enhanced the uptake of glucose by hemidiaphragm but it was not comparable to the standard drug glibenclamide. Furthermore, galactomannan lowered lipid peroxidation and elevated the levels of antioxidant enzymes. The present study demonstrates that fenugreek galactomannan exhibits little antioxidant activity and little effect on peripheral glucose uptake. Further scope is there to study galactomannan's different antidiabetic mechanism(s) of actions. (Source: Journal of C...

Action of Portulaca oleracea against Streptozotocin-Induced Oxidative Stress in Experimental Diabetic Rats

Journal of Complementary and Integrative Medicine — Tue, 06 Jan 2009 00:40:15 +0100

Antidiabetic treatment with an extract of Portulaca oleracea leaves (100mg/kg and 250mg/kg body weight) for three weeks showed a significant reduction in thiobarbituric acid reactive substances (TBRAS) and an increase in glutathione reductase (GSH-R) in both the liver and kidney of STZ diabetic rats. The treatment with P. oleracea significantly altered the glutathione and GSH-R to be comparable with the control group. P. oleracea- and tolbutamide-treated rats showed decreased lipid peroxidation that is associated with increased activity of superoxide dismutase (SOD) and catalase(CAT). The effects of P. oleracea on tissue lipid peroxidation and antioxidant status in diabetic animals have not been studied before. The result of this study thus shows that although P. oleracea extract possesses...

Cardioprotective Activity of Polyherbal Extracts in Experimental Myocardial Necrosis in Rodents: An Evidence of Antioxidant Activity

Journal of Complementary and Integrative Medicine — Wed, 24 Dec 2008 01:36:18 +0100

The present study investigates the antioxidant activity of A.V. Circulo (AVC), a polyherbal formulation in isoproterenol(ISO)-induced oxidative stress in rats and attempts to correlate its cardioprotective activity with antioxidant activity. Myocardial necrosis was produced in rats with ISO (85 mg/kg, s.c.), injected twice at an interval of 24 h. AVC (500 mg/kg, p.o.) was administered to rats for 21 days and 45 days and its effect was evaluated on ISO-induced cardiac injury. The marker enzymes - AST, LDH & CPK were assayed in serum and heart, and antioxidant parameters, viz., reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) & glutathione reductase (GR), and malondialdehyde (MDA), were determined in heart homogenate. Significant myocardial ...

Crude Extract of Turmeric Reduces Hepato-Toxicity and Oxidative Stress in Rats Chronically Fed Carcinogens

Journal of Complementary and Integrative Medicine — Tue, 16 Dec 2008 23:49:16 +0100

The crude extract of turmeric (Curcuma longa L.; Zingiberaceae) is widely used in traditional systems of medicine like Ayurveda as a remedy for various diseases. Although various medicinal effects of its active principle, Curcumin, have been extensively studied in various animal models, there appears to be no systematic study on whether the crude extract can reduce hepato-toxicity and oxidative stress in rats induced by chronic feeding of p-dimethyl aminoazobenzene and phenobarbital, two known carcinogens of liver. Tests were conducted in experimental and controlled animals involving several widely accepted toxicity biomarkers at four fixation intervals, namely, 30, 60, 90, and 120 days. Results revealed an increase in activities of acid and alkaline phosphatases, alanine and aspartate ami...

Complementary and Alternative Medicine Use in Juvenile Idiopathic Arthritis: A Systematic Review of Prevalence and Evidence

Journal of Complementary and Integrative Medicine — Mon, 15 Dec 2008 20:52:23 +0100

The objective of this manuscript is to provide healthcare professionals and researchers with a comprehensive review of the prevalence of CAM use in JIA, determinants of use, and outcomes associated with various therapies. The implications for future clinical practice and promising areas of investigation will be discussed. An in-depth search was conducted in MEDLINE, EMBASE, AMED, and Cochrane Library. Programs from relevant conferences were also searched. Thirty-eight articles were retrieved and 12 were included in the analysis. Eight articles assessed the prevalence of CAM use in JIA, three investigated specific interventions (Tripterygium wilfordii Hook F, relaxation, massage), and one examined reasons for using CAM. Results showed that CAM use is relatively high among JIA patients, but ...

Antidiabetic Activity Assessment of Argania spinosa Oil

Journal of Complementary and Integrative Medicine — Tue, 02 Dec 2008 01:12:11 +0100

Background: Argan or Argania spinosa (L.) Skeels, of the family sapotaceae which is an endemic species of the western south Morocco is used for its antidiabetic activity in local traditional medicine. All the parts of the plants are used to prepare remedies against various diseases. Recently, some studies suggest that Argan oil could play a beneficial role in cardiovascular diseases prevention.Aim: The goal of the present work is to show more evidences of the antidiabetic activity of Argan oil extracted from the almonds of Argan tree. Methods: In a first experiment, we tested the antihyperglycemiant effect on oral glucose tolerance test in healthy rats and streptozotocin-induced diabetic rats (60 mg/kg). In the second subchronic study, we tested the effect of the repeated oral administrati...

Research that Matters: Linking Researchers, Practitioners, Decision-Makers and the Public: Abstracts from the Fifth Annual IN-CAM Research Symposium November 7 to 9, 2008, Toronto, Canada

Journal of Complementary and Integrative Medicine — Wed, 05 Nov 2008 13:43:11 +0100

The following are abstracts of oral and poster presentations given at the Fifth Annual IN-CAM Research Symposium - Research that Matters: Linking Researchers, Practitioners, Decision-Makers and the Public, held on November 7, 8 & 9, 2008 at the Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada. The Symposium was held in collaboration with two IN-CAM partners, PedCAM and HomeoNet. The abstracts are grouped under: IN-CAM, PedCAM, and HomeoNet. For more information, please visit: www.incamresearch.ca. (Source: Journal of Complementary and Integrative Medicine)

Systematic Follow-Up of a Cohort of Smokers Who Received a Standard Smoking Cessation Intervention with Soft Laser Therapy

Journal of Complementary and Integrative Medicine — Fri, 31 Oct 2008 19:16:32 +0100

Discussion:Our results suggest a possible effect of the SLT that would be in the high range of those observed with other interventions. However, absence of control group and other limitations prevent making any conclusion. Double blind placebo controlled randomized trials need to be conducted. (Source: Journal of Complementary and Integrative Medicine)

Hypoglycemic Activity of Aqueous Extract of Oscillatoria limnetica, Blennothrix ganeshii, Hydrodictyon reticulatum and Microcoleous lacustris in Normal and Alloxan Induced Diabetic Mice

Journal of Complementary and Integrative Medicine — Mon, 13 Oct 2008 19:32:15 +0100

This study shows that algae extracts have significant activity on glucose levels in rats. (Source: Journal of Complementary and Integrative Medicine)

Antioxidant and Acetylcholinesterase Inhibitory Properties of the Indian Medicinal Plant "Shankhapushpi" Used for Enhancing Memory Function

Journal of Complementary and Integrative Medicine — Wed, 08 Oct 2008 15:50:16 +0100

Objective - At least seven plants known as Shankhapushpi are used in Indian system of medicine for improving memory function. The present study was aimed to analyze the antioxidant and acetylcholinesterase inhibitory properties of the methanolic extracts of five of these plants, e.g. Clitorea ternatea, Canscora decussata, C. diffusa, Evolvulus alsinoides, E. nummularius.Methods - Acetylcholinesterase activity was assayed modifying the method of Ellman et al. (1961) using mice brain homogenates as the enzyme source. Antioxidant activity of the extracts were determined by measuring DPPH radical and superoxide radical scavenging activity, metal chelation effect and total antioxidant capacity.Results - All the plants (except C. ternatea) inhibited acetylcholinesterase in a dose dependant manne...

Australian Natural Therapists and Mental Health: Survey of Treatment Approaches and Referral Patterns

Journal of Complementary and Integrative Medicine — Tue, 30 Sep 2008 16:59:58 +0100

This study was an initial examination of practice by Australian naturopaths and Western herbalists in their treatment of insomnia, anxiety and depression. Types of treatments provided and the nature of interactions with mental health professionals were explored. Sixty-nine participants (response rate approximately 9%) completed a questionnaire devised by the authors. A variety of natural medicine modalities were chosen to treat each condition, most frequently herbs, lifestyle advice and dietary modification. Evidence was found for some degree of consistency in the treatment approaches taken to mental health issues, suggestive of common practice approaches amongst suitably qualified practitioners. Findings also indicate considerable interaction between naturopaths/herbalists and mental heal...

The Effects of Borage Oil Supplementation on Non-Steroidal Anti-Inflammatory Drug Requirements in Patients with Rheumatoid Arthritis

Journal of Complementary and Integrative Medicine — Mon, 29 Sep 2008 20:21:12 +0100

Conclusion: This study suggests that Borage oil does has a beneficial effect on controlling pain. (Source: Journal of Complementary and Integrative Medicine)

Antiangiogenic Effects of Chinese Medicines (Hachimijiogan and Kogikujiogan) on Vascular Endothelial Growth Factor-A-Induced Tube Formation in Human Umbilical Vein Endothelial Cells Co-Cultured with Fibroblasts

Journal of Complementary and Integrative Medicine — Tue, 26 Aug 2008 00:00:16 +0100

The aim of this study was to examine the antiangiogenic properties and antioxidant activities of two Chinese medicines (Hachimijiogan and Kogikujiogan). Each of these medicines concentration-dependently inhibited vascular endothelial growth factor-A (VEGF-A)-induced tube formation in a co-culture of human umbilical vein endothelial cells (HUVECs) and fibroblasts. In addition, they each at 100 μg/ml inhibited the VEGF-A-induced cell proliferation of HUVECs. Hachimijiogan at 10 and 100 μg/ml and Kogikujiogan at 100 μg/ml also inhibited the VEGF-A-induced cell migration of HUVECs, and Hachimijiogan at 50 μg/ml and Kogikujiogan at 5, 50, and 100 μg/ml inhibited lipid peroxidation in mouse forebrain homogenates. These findings indicate that Hachimijiogan and Kogikujiogan have antiangiogeni...

Comparative Analysis of CAM Use in the U.S. Cancer and Noncancer Populations

Journal of Complementary and Integrative Medicine — Wed, 20 Aug 2008 03:31:50 +0100

Conclusion: While these patterns may have begun during the initial period of cancer diagnosis and treatment, they continue among long-term survivors. Predisposing, enabling, and need factors were strong predictors of CAM use in both populations. (Source: Journal of Complementary and Integrative Medicine)

Hypolipidemic Activity Evaluation of DRF/AY/4013, an Herbal Formulation in Experimentally Induced Hyperlipidemic Rats

Journal of Complementary and Integrative Medicine — Sat, 12 Jul 2008 02:13:45 +0100

The present study was designed to evaluate the efficacy of an herbal product DRF/AY/4013 for its hypolipidemic activity in various experimental rat models. An indigenous polyherbal formulation DRF/AY/4013, composed of different phytoconstituents like Terminalia arjuna, Commiphora mukul, Allium sativum, Cyperus rotundus and Acorus calamus extracts, exhibited potential hypolipidemic activity treatment in triton induced hyperlipidemic rats. Further, it also showed promising hypolipidemic activity in both high fat diet (HFD) induced hyperlipidemic rats and propylthiouracil (PTU) induced hyperlipidemic rats. In all the experimental hyperlipidemic models, DRF/AY/4013 treatment demonstrated dose dependent hypolipidemic activity at 200, 400 and 800 mg/kg dose levels by decreasing serum lipid and l...

Lepidium meyenii (Maca) Varieties Did Not Alter Female Reproductive Parameters in Adult Intact Rats

Journal of Complementary and Integrative Medicine — Fri, 11 Jul 2008 13:56:05 +0100

The main goal of this study was to evaluate the effect of three different varieties of Lepidium meyenii (Black, Yellow and Red Maca) during seven estrous cycles in rats. Adult female rats (n=8 per group) were treated with freeze-dried aqueous extract of each maca variety (1 g/kg) during 28 days. The duration of each phase of the estrous cycle and body weight was determined. Animals were sacrificed in first estrous phase after seven estrous cycles and the number of ova from oviduct, wet uterine and body weight and estradiol levels were recorded. Total polyphenols content found in black, yellow and red maca freeze-dried was 0.56, 0.57 and 0.58 g/100g of lyophilized respectively. The maca varieties did not affect any phase of estrous cycle, number of ova recovered within oviduct, serum estrad...

Protective Role of Grewia asiatica on Blood after Radiation Exposure in Mice

Journal of Complementary and Integrative Medicine — Tue, 01 Jul 2008 23:30:06 +0100

Conclusion: It showed that GAE provides protection against radiation-induced alterations in blood of mice. (Source: Journal of Complementary and Integrative Medicine)

Magnetotherapy: Changes in the Nature of Biomolecules under a Constant Magnetic Field

Journal of Complementary and Integrative Medicine — Tue, 17 Jun 2008 23:29:23 +0100

Doses of 0.0175 Weber m-2 magnetic fields were given to four series of biomolecules for up to 40 minutes in aqueous solution. During this, every 5 minutes, viscosities (η) were measured at 303.15 K and one atmospheric pressure. The source of the magnetic field of 0.0175 Weber m-2 was generated by putting two permanent magnets around the solutions. Interestingly, the viscosities of the bimolecules responded to the magnetic field dose and the length of the field exposure with time as compared to their viscosities without a magnetic dose. An initial magnetic dose of 5 minutes causes a drastic decrease in viscosities for vitamins, amino acids and carbohydrates, and a slight decrease for proteins due to the hydrogen-bonded peptides framework. The vitamins, amino acids and carbohydrates show de...

The Antioxidant Defense System Induced by Methanol Extract of Careya arborea in N-Nitroso-diethylamine (NDEA) Induced Hepatocarcinogenesis

Journal of Complementary and Integrative Medicine — Thu, 22 May 2008 03:13:05 +0100

The methanol extract of stem barks of Careya arborea Roxb (MECA) (Family- Myrtaceae) was evaluated against hepatocellular carcinoma induced by N-nitrosodiethylamine (NDEA). NDEA is a widely used experimental tool to induce cancer in animals causing oxidative stress and cellular injury due to the enhanced formation of free radicals and is associated with rise in biochemical parameters like serum glutamyl pyruvate transaminase (SGPT), serum glutamyl oxalacetic acid (SGOT), serum alkaline phosphatase (SALP), bilirubin, as well as decrease in the levels of total protein and uric acid. Furthermore, the protective effect of Careya arborea against perturbations in the levels of antioxidant defense system was also estimated. The MECA was administered at the doses of 100 and 200 mg/kg body weight/r...

Evaluation of Antioxidant and Free Radical Scavenging Activities of Oxystelma esculentum in Various In Vitro Models

Journal of Complementary and Integrative Medicine — Wed, 21 May 2008 00:24:21 +0100

Conclusion - The results suggest that the methanol extract of Oxystelma esculentum proved its strong antioxidant activity and can be used as a natural antioxidant. (Source: Journal of Complementary and Integrative Medicine)

Research Advances on the Anti-aging Profile of Fructus lycii: an Ancient Chinese Herbal Medicine

Journal of Complementary and Integrative Medicine — Wed, 21 May 2008 00:21:31 +0100

Fructus lycii is a common Chinese herbal medicine used in China for nearly 2000 years. It has beneficial effects on eyes, liver and kidneys; and it has long been considered to be an anti-aging herb in ancient Chinese medicine. Modern studies have partially probed the magic anti-aging property of F. lycii. The beneficial effects of F. lycii on aging are largely attributed to its bioactive components such as polysaccharides, carotenoids and flavonoids. This review focuses on the anti-aging aspect of F. lycii, elaborating the bioactive ingredients accounting for the property, anti-aging pharmacology in terms of its antioxidation capacity, immunomodulative effect and neuroprotective activity. (Source: Journal of Complementary and Integrative Medicine)