MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Journal of Cutaneous Pathology' source. Thu, 09 Feb 2012 00:42:15 +0100 http://www.medworm.com/index.php?rid=5669161&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2012.01888.x Conclusion: Demonstration of complete PTEN loss in TL by IHC is strongly suggestive of association with CS, but retention of PTEN staining does not entirely exclude CS. Therefore, PTEN IHC in trichilemmomas may be helpful in screening TL for association with CS, but should be used in context with other established clinical criteria, and possibly germline PTEN genotyping to confirm a diagnosis of CS. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5669161 Wed, 01 Feb 2012 05:00:00 +0100 5669161 http://www.medworm.com/index.php?rid=5661194&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2012.01883.x Conclusions: Increased Twist protein expression in advanced MF/SS lesions suggests that Twist expression may correlate with MF/SS stages. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5661194 Wed, 01 Feb 2012 05:00:00 +0100 5661194 http://www.medworm.com/index.php?rid=5639869&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2012.01876.x We present a series of seven desmoplastic trichoepitheliomas with otherwise typical presentation and morphology, nevertheless demonstrating epithelium present in the perineural spaces of adjacent small dermal nerves. Patients ranged in age from 14 to 66 years (mean 44 years). All seven tumors were restricted to dermis, showed strands of basaloid epithelium in desmoplastic stroma, and contained CK20‐positive cells. Additionally, five of five examined tumors displayed diffuse expression of p75 neurotrophin receptor. Five patients were followed‐up clinically (follow‐up time range: 2 months ‐ 4 years). No tumor recurrence was observed in any of these patients. We postulate that perineural involvement is an unusual feature of desmoplastic trichoepithelioma that should not be equated wit... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5639869 Mon, 30 Jan 2012 06:28:50 +0100 5639869 http://www.medworm.com/index.php?rid=5630917&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2012.01880.x We present a novel and unique clinical presentation in an African‐American female patient, consisting of regular hypopigmented annular rings in areas of normal skin and in more typical hypopigmented patches of mycosis fungoides. The lesions appeared diffusely on all extremities, anterior chest, and back. Histopathologic examination showed an atypical lymphocytic infiltrate at the dermal‐epidermal junction with epidermotropism and few Pautrier's collections. The patient was otherwise healthy and improved with narrowband ultraviolet (UV)‐B. This case represents a presentation of a most unusual variant of hypopigmented mycosis fungoides, for which we propose the name “annular hypopigmented mycosis fungoides.” (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5630917 Fri, 27 Jan 2012 05:27:49 +0100 5630917 http://www.medworm.com/index.php?rid=5611943&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2012.01875.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5611943 Sat, 21 Jan 2012 04:54:04 +0100 5611943 http://www.medworm.com/index.php?rid=5611942&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01840.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5611942 Sat, 21 Jan 2012 04:54:02 +0100 5611942 http://www.medworm.com/index.php?rid=5611941&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01839.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5611941 Sat, 21 Jan 2012 04:54:00 +0100 5611941 http://www.medworm.com/index.php?rid=5611940&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01826.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5611940 Sat, 21 Jan 2012 04:53:56 +0100 5611940 http://www.medworm.com/index.php?rid=5611939&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2012.01864.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5611939 Sat, 21 Jan 2012 04:53:31 +0100 5611939 http://www.medworm.com/index.php?rid=5611938&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2012.01865_2.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5611938 Sat, 21 Jan 2012 04:53:29 +0100 5611938 http://www.medworm.com/index.php?rid=5585661&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01829.x We report a case of EBV‐positive mucocutaneous ulcer secondary to prolonged use of azathioprine for the treatment of pemphigoid and highlight the need for recognition of this disorder by dermatopathologists and dermatologists.McGinness JL, Spicknall KE, Mutasim DF. Azathioprine‐induced EBV‐positive mucocutaneous ulcer. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5585661 Wed, 11 Jan 2012 05:00:00 +0100 5585661 http://www.medworm.com/index.php?rid=5585660&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01833.x Acute primary cutaneous leishmaniasis typically presents microscopically with a lymphohistiocytic infiltrate containing admixed plasma cells, parasitized macrophages and abundant organisms. Tuberculoid granulomatous changes may occur in the later phases of primary infection. A 23‐year‐old male presented 1 month after visiting Peru with classic clinical findings of acute primary cutaneous leishmaniasis, while histopathology showed a tuberculoid granulomatous process that lacked any organisms in hematoxylin–eosin and fungal stains. Polymerase chain reaction (PCR) analysis and tissue cultures confirmed the diagnosis of cutaneous leishmaniasis with Leishmania (Viannia) panamensis infection. A pauci‐organism tuberculoid granulomatous process may uncommonly be the presenting histopatholo... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5585660 Wed, 11 Jan 2012 05:00:00 +0100 5585660 http://www.medworm.com/index.php?rid=5585659&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01815.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5585659 Wed, 11 Jan 2012 05:00:00 +0100 5585659 http://www.medworm.com/index.php?rid=5585658&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01816.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5585658 Wed, 11 Jan 2012 05:00:00 +0100 5585658 http://www.medworm.com/index.php?rid=5585657&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01819.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5585657 Wed, 11 Jan 2012 05:00:00 +0100 5585657 http://www.medworm.com/index.php?rid=5585656&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01825.x Conclusions: The most reliable marker to distinguish clonal SK from pagetoid SCCIS is cytokeratin 10 when it spares nests. Other criteria that assist in the differential diagnosis are bcl‐2 expression, absence of crowding and of mitoses.Böer‐Auer A, Jones M, Lyasnichaya OV. Cytokeratin 10‐negative nested pattern enables sure distinction of clonal seborrheic keratosis from pagetoid Bowen's disease. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5585656 Wed, 11 Jan 2012 05:00:00 +0100 5585656 http://www.medworm.com/index.php?rid=5585655&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01835.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5585655 Wed, 11 Jan 2012 05:00:00 +0100 5585655 http://www.medworm.com/index.php?rid=5585654&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01834.x Conclusion: Proliferation index is not significantly different between KA and hypertrophic LP (p = 0.059). Expression of p53 is increased in KA over hypertrophic LP (p = 0.024). The presence of perforating elastic fibers in KA is significantly different from hypertrophic LP (p < 0.0001) and suggests that elastic Verhoeff‐van Gieson staining may be of practical benefit in distinguishing KA from hypertrophic LP in difficult cases.Bowen AR, Burt L, Boucher K, Tristani‐Firouzi P, Florell SR. Use of proliferation rate, p53 staining and perforating elastic fibers in the distinction of keratoacanthoma and hypertrophic lichen planus: a pilot study. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5585654 Wed, 11 Jan 2012 05:00:00 +0100 5585654 http://www.medworm.com/index.php?rid=5585653&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2012.01866.x We present two patients with a previous diagnosis of psoriasis who presented to our dermatology department with an exfoliative erythroderma, which ultimately proved to be due to PF based on histopathological features, direct immunofluorescence results, and levels of antibodies against desmoglein 1. Both patients responded well to oral prednisone and rituximab. This variant of PF should be entertained in both the clinical differential diagnosis of psoriasiform erythroderma and in the microscopic differential diagnosis of psoriasiform epidermal hyperplasia with focal acantholysis, particularly in patients for whom the clinical history is not classic for psoriasis or for whom conventional psoriasis therapies have not proven beneficial. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5585653 Tue, 10 Jan 2012 05:00:00 +0100 5585653 http://www.medworm.com/index.php?rid=5585652&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2012.01872.x We report a 40‐year‐old man with classical Hodgkin lymphoma who developed cutaneous nodules. A biopsy from one revealed Hodgkin/Reed‐Sternberg cells with a similar immunophenotype to the diagnostic lymph node biopsy, namely CD30+/CD15+, diffusely but weakly PAX5+, focally weakly Oct‐2+, and lacking BOB.1 expression, thereby confirming a diagnosis of cutaneous Hodgkin lymphoma. To our knowledge, this is the first report of the expression of the combination of PAX5, Oct‐2, and BOB.1 in the context of cutaneous involvement by Hodgkin lymphoma. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5585652 Tue, 10 Jan 2012 05:00:00 +0100 5585652 http://www.medworm.com/index.php?rid=5585651&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2012.01873.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5585651 Sun, 01 Jan 2012 05:00:00 +0100 5585651 http://www.medworm.com/index.php?rid=5553711&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01855.x We report a case of an ‘osteochondrolipoma’ of the chest wall, in a young individual, providing a rationale in support of this as a possible and distinctive histologic subtype of lipomas, as well as discussion in the differential diagnosis of this lesion.Gru AA, Santa Cruz, DJ. Osteochondrolipoma: a subcutaneous lipoma with chondroid and bone differentiation of the chest wall. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5553711 Sun, 01 Jan 2012 04:54:03 +0100 5553711 http://www.medworm.com/index.php?rid=5553712&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01854.x Conclusions: Even though CD56 is a useful marker for certain cytotoxic lymphomas and neural/neuroendocrine neoplasms, its expression is not limited to these conditions. Our cases highlight another unexpected example of strong CD56 expression in the skin: damaged and/or regenerating muscle fibers. The growing list of CD56‐positive conditions suggests that this marker may not be as specific as initially assumed.Mckay K, McNiff J, Subtil A. Prominent CD56 expression by damaged and regenerating muscle fibers in the skin. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5553712 Thu, 29 Dec 2011 05:00:00 +0100 5553712 http://www.medworm.com/index.php?rid=5546071&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01847.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5546071 Wed, 28 Dec 2011 21:29:06 +0100 5546071 http://www.medworm.com/index.php?rid=5546070&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01830.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5546070 Wed, 28 Dec 2011 21:29:04 +0100 5546070 http://www.medworm.com/index.php?rid=5546069&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01841.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5546069 Wed, 28 Dec 2011 21:29:03 +0100 5546069 http://www.medworm.com/index.php?rid=5546068&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01785.x We report a case of angiosarcoma arising after 33 years within a background of filariasis. Awareness of this association can lead to early diagnosis and appropriate treatment of this potentially fatal malignant tumor.Krishnamoorthy N, Viswanathan S, Rekhi B, Jambhekar NA. Lymphangiosarcoma arising after 33 years within a background of chronic filariasis: a case report with review of literature. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5546068 Wed, 28 Dec 2011 21:28:50 +0100 5546068 http://www.medworm.com/index.php?rid=5546067&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01800.x The histopathological features of atypical fibroxanthoma (AFX) overlap with those of poorly differentiated carcinoma, melanoma and leiomyosarcoma in the skin. As there are no specific stains to identify AFX, the diagnosis is essentially one of exclusion and requires completion of a panel of immunostains. Recently, it has been suggested that the macrophage/monocyte‐specific marker CD163 is of value in identifying AFX. To investigate this claim, 57 AFX were stained for CD163. Only 21 of 57 (37%) of AFX stained positively, and intratumoral macrophages confounded interpretation of the stain at times. In four cases, it was not possible to definitively interpret the tumor staining reaction because of this effect. While a lack of stainable CD163 antigenicity may indicate that AFX is not of hist... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5546067 Wed, 28 Dec 2011 21:28:43 +0100 5546067 http://www.medworm.com/index.php?rid=5546066&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01850.x Editor's note: This manuscript represents a reprise of the preceding manuscript (J Cutan Pathol 2012; 39: 21–24). It has different conclusions. The wording of the case report section is very similar in both papers but has been included in both for the convenience of the reader. The illustrations are duplicated in both versions of the manuscript but the captions are not the same. The reader is encouraged to study both versions of the manuscript and consider the issue from both perspectives.McCalmont TH, Bastian BC. An unconventional deep penetrating melanocytic nevus with microscopic involvement of regional lymph nodes. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5546066 Wed, 28 Dec 2011 21:28:42 +0100 5546066 http://www.medworm.com/index.php?rid=5546065&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01849.x We present a case of a pigmented lesion on the right cheek of a 4 year old boy. The lesion had features of a deep penetrating nevus, but the presence of frequent mitoses, tumor infiltrating lymphocytes, and microscopic foci of tumor necrosis were concerning for an unusual melanoma. We termed this lesion a melanocytic tumor of uncertain potential (MELTUMP) for these reasons. High‐resolution array‐CGH performed elsewhere on the lesion demonstrated no melanoma‐associated genomic abnormalities. A sentinel lymph node biopsy of this patient later revealed multiple small tumor deposits. Although the presence of nodal involvement in similar lesions often do not lead to progressive and fatal disease, this case illustrates that atypical melanocytic lesions with nodal involvement may not demons... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5546065 Wed, 28 Dec 2011 21:28:40 +0100 5546065 http://www.medworm.com/index.php?rid=5546064&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01848.x The rise in malignant melanoma incidence has been termed “epidemic”. Closer scrutiny of epidemiologic data suggests overdiagnosis as the true cause of the dramatic rise in melanoma incidence. In epidemiologic terms, “overdiagnosis” describes lesions that are histologically malignant but biologically benign. Overdiagnosis is not unique to melanoma screening but is prevalent in screening for cancers of other organs, including the thyroid and prostate glands.Glusac EJ. The melanoma ‘epidemic’: lessons from prostate cancer. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5546064 Wed, 28 Dec 2011 21:28:38 +0100 5546064 http://www.medworm.com/index.php?rid=5546063&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01831.x In the past decades, the incidence of melanoma has been reported to rise in epidemic proportions. The chief reason for that pseudo‐epidemic is improved criteria for diagnosis that allow melanomas to be recognized far more accurately and at earlier stages. The rising number of melanomas diagnosed has resulted in increased diagnostic scrutiny, more pigmented lesions being biopsied and more melanomas recognized, thus enhancing the ‘epidemic’ in self‐perpetuating fashion. Regression of melanomas may, in part, explain why lesions undetected before did not result in a far higher mortality. Another potential reason for the disparity between increasing incidence of melanoma and relatively steady mortality may be overdiagnosis of melanoma. The latter may be curtailed by establishment of wel... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5546063 Wed, 28 Dec 2011 21:28:36 +0100 5546063 http://www.medworm.com/index.php?rid=5546062&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01851.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5546062 Wed, 28 Dec 2011 21:28:35 +0100 5546062 http://www.medworm.com/index.php?rid=5546061&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01846.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5546061 Wed, 28 Dec 2011 21:28:33 +0100 5546061 http://www.medworm.com/index.php?rid=5546060&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01845_2.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5546060 Wed, 28 Dec 2011 21:28:32 +0100 5546060 http://www.medworm.com/index.php?rid=5546058&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01814.x We report a case of HHV8‐associated lymphoma histopathologically and immunophenotypically mimicking cutaneous anaplastic large cell lymphoma. The patient was a 31‐year‐old HIV‐seropositive man presenting with skin nodules over his right thigh. Biopsy of the nodules showed anaplastic large cells infiltrating the dermis. These malignant cells strongly expressed CD3, CD30 and CD43. Cutaneous anaplastic large T‐cell lymphoma was initially diagnosed, but further tests, including immunoreactivity for HHV8 protein and clonal rearrangements of immunoglobulin genes, confirmed the diagnosis of HHV8‐associated B‐cell lymphoma with aberrant T‐cell marker expression. This case provides an example of solid primary effusion lymphoma mimicking cutaneous anaplastic large T‐cell lymphoma a... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5546058 Wed, 28 Dec 2011 21:27:53 +0100 5546058 http://www.medworm.com/index.php?rid=5507261&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01838.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5507261 Thu, 15 Dec 2011 05:00:00 +0100 5507261 http://www.medworm.com/index.php?rid=5507260&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01844.x Conclusions: The manifestations of cutaneous leishmaniasis are broad and may mimic other inflammatory and neoplastic diseases. Pathologists and dermatologists should be aware of such pitfalls and can utilize PCR to confirm the diagnosis of leishmaniasis.Saab J, Fedda F, Khattab R, Yahya L, Loya A, Satti M, A‐G Kibbi, Houreih MA, Raslan W, El‐Sabban M, Khalifeh I. Cutaneous leishmaniasis mimicking inflammatory and neoplastic processes: a clinical, histopathological and molecular study of 57 cases. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5507260 Thu, 01 Dec 2011 05:00:00 +0100 5507260 http://www.medworm.com/index.php?rid=5496794&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01836.x Pilomatrixomas are benign follicular tumors that occur most commonly in children. Rare multiple or familial pilomatrixomas have been associated with myotonic dystrophy and other disorders. Although sporadic pilomatrixomas and hybrid cutaneous cysts with pilomatrixoma‐like features have been observed in some kindreds with Gardner syndrome, an autosomal dominant form of familial adenomatous polyposis, no definitive association has been made with multiple or familial pilomatrixomas. Here we describe two siblings with multiple pilomatrixomas who were also found to have a family history of colonic adenocarcinoma. Genetic testing revealed a mutation in the 5′ portion of the adenomatous polyposis coli (APC) gene, in a region associated with an attenuated APC phenotype. These findings show tha... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5496794 Thu, 01 Dec 2011 05:00:00 +0100 5496794 http://www.medworm.com/index.php?rid=5460322&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01843.x Conclusion: Amplification of MYC and nuclear expression of MYC is present in secondary angiosarcoma but not AVL. These ancillary tests can be useful to distinguish angiosarcoma from AVL in difficult cases.Fernandez AP, Sun Y, Tubbs RR, Goldblum JR, Billings SD. FISH for MYC amplification and anti‐MYC immunohistochemistry: useful diagnostic tools in the assessment of secondary angiosarcoma and atypical vascular proliferations. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5460322 Thu, 01 Dec 2011 05:00:00 +0100 5460322 http://www.medworm.com/index.php?rid=5460325&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01827.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5460325 Tue, 29 Nov 2011 05:00:00 +0100 5460325 http://www.medworm.com/index.php?rid=5460324&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01828.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5460324 Tue, 29 Nov 2011 05:00:00 +0100 5460324 http://www.medworm.com/index.php?rid=5460323&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01832.x We describe a case of blastic primary cutaneous mantle cell lymphoma (MCL) in an 83‐year‐old male with a complex medical history. The patient presented to his primary care physician with a nodular erythematous skin eruption on his thighs. Histopathologic examination showed a diffuse lymphoid infiltrate of intermediate to large cells that involved the dermis and subcutis but spared the epidermis. Immunohistochemical staining showed expression of CD20, CD5 and cyclin‐D1. The lymphoma cells were negative for CD10 and CD23. Fluorescence in situ hybridization (FISH) analysis revealed a characteristic translocation [t(11;14)(q13;q32)], which is diagnostic of MCL. Cutaneous involvement by MCL is typically secondary because of widespread disease, and primary cutaneous MCL can only be diagnos... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5460323 Tue, 29 Nov 2011 05:00:00 +0100 5460323 http://www.medworm.com/index.php?rid=5433466&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01823.x Vascular tumors are categorized into benign hemangiomas, frankly malignant angiosarcomas and tumors with intermediate biological behavior (hemangioendotheliomas). The latter group includes hemangioendotheliomas of the epithelioid, kaposiform, retiform and composite subtypes. Furthermore, a heterogeneous group of both benign and intermediate vascular tumors exhibits a peculiar hobnail cell morphology. This heterogeneous group encompasses hobnail hemangioma, retiform hemangioendothelioma, papillary intralymphatic angioendothelioma and a subset of angiosarcoma. We herein present a case of a cutaneous vascular neoplasm with hobnail morphology and unusual gross features.Wachter DL, Agaimy A. A cutaneous vascular neoplasm with hobnail microscopic morphology and unusual gross features. (Source: J... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5433466 Tue, 22 Nov 2011 17:33:03 +0100 5433466 http://www.medworm.com/index.php?rid=5401989&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01807.x A 62‐year‐old man presented with a 2‐year history of a 2‐cm cystic mass involving his occiput. There had been recent enlargement, and the clinical impression was that of a pilar cyst. Histopathological sections showed a partially dermal solid and cystic proliferation. The tumor contained areas of glandular differentiation with cuboidal to columnar cells lining luminal and cystic spaces. A concurrent spindle cell proliferation was seen interspersed between glands and also formed broad, cellular sheets of cells. The stroma was sclerotic and without chondroid or myxoid elements. Immunohistochemistry showed that the spindled cells expressed S100 protein, cytokeratin and smooth muscle myosin. The immunohistochemical profile and the relationship with ductal elements supported myoepitheli... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5401989 Sun, 13 Nov 2011 17:00:33 +0100 5401989 http://www.medworm.com/index.php?rid=5401996&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01811.x We report a case of a 65‐year‐old woman with B‐cell chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) who presented with multiple, tender, firm pink papules on the face, upper trunk and upper extremities 6 years after diagnosis of CLL. Biopsy revealed both palisading granulomatous dermatitis consistent with actinic granuloma and a dense perivascular lymphocytic infiltrate consistent with the patient's known history of leukemia. This is an unusual manifestation of cutaneous B‐cell CLL that is rarely seen.Kauffman JA, Ivan DS, Cutlan JE, Hymes SR. Actinic granuloma occurring in an unusual association with cutaneous B‐cell chronic lymphocytic leukemia. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5401996 Sat, 12 Nov 2011 05:00:00 +0100 5401996 http://www.medworm.com/index.php?rid=5401995&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01812.x This article demonstrates that the amyloid observed in this context is generally positive for Congo red, crystal violet and thioflavin T. It also expresses cytokeratin 34ßE12 via immunohistochemistry. Our immunohistochemical results and review of the literature suggest that the amyloid in amyloidosis of the external ear is the result of basal keratinocyte degeneration and does not signify deposition from a systemic or generalized process.Wenson SF, Jessup CJ, Johnson MM, Cohen LM, Mahmoodi M. Primary cutaneous amyloidosis of the external ear: a clinicopathological and immunohistochemical study of 17 cases. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5401995 Sat, 12 Nov 2011 05:00:00 +0100 5401995 http://www.medworm.com/index.php?rid=5401994&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01817.x We present the case of a patient carrying a previous diagnosis of pemphigus vulgaris, status posttreatment with methotrexate and prednisone, who developed a perineal ulcer exhibiting significant numbers of plasma cells, many of which were cytologically atypical. This morphology was suggestive of a hematopoietic malignancy. Immunoperoxidase staining for HSV decorated a focal collection of keratinocytes that lacked appreciable viral changes expected of HSV infection.Boyd AS, Zwerner JP, Miller JL. Herpes simplex virus‐induced plasmacytic atypia. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5401994 Sat, 12 Nov 2011 05:00:00 +0100 5401994 http://www.medworm.com/index.php?rid=5401993&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01783.x A 16‐year‐old girl with polycystic ovarian syndrome presented with numerous rufous papules arising within a large depigmented macule that developed following a severe scald injury on the back. Histopathology revealed that many mature sebaceous glands were growing in the middle and bottom of the epidermis with slight acanthosis. On the basis of patient history, clinical manifestation and histopathology, we suggested that this patient's skin lesion be diagnosed as ‘sebaceous hyperplasia within epidermis after scald’.Yin Z, Xu J, Luo D, Zhang M. Sebaceous hyperplasia within epidermis after scald. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5401993 Sat, 12 Nov 2011 05:00:00 +0100 5401993 http://www.medworm.com/index.php?rid=5401992&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01810.x We present a patient with a 2‐cm spiradenocarcinoma of the left arm resembling low‐grade salivary gland basal cell adenocarcinoma. In addition to showing attributes of conventional spiradenoma, the benign component showed prominent areas of cystic change with focal apocrine differentiation, glands with and without mucinous differentiation, clear cell change and focal adenoid cystic carcinoma‐like areas. The malignant component was composed of nodules of basaloid cells arranged in sheets with variable tendency to luminal differentiation. The nuclear atypia was low‐grade, and the mitotic index was high in the malignant component (to 8/10 high power fields). Immunohistochemically, there was diffuse but variable positivity for cytokeratin 7 in both the benign and malignant components. ... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5401992 Sat, 12 Nov 2011 05:00:00 +0100 5401992 http://www.medworm.com/index.php?rid=5401991&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01813.x We describe two families with Brooke‐Spiegler syndrome, one with familial cylindromatosis and one with multiple familial trichoepithelioma, which showed wide inter‐family phenotypic variability. Analysis of germline mutations of the CYLD and PTCH genes was performed using peripheral blood. In addition, formalin‐fixed paraffin‐embedded tumor samples were analyzed for PTCH somatic mutations and cylindroma cell cultures were obtained directly from patients for further growth and analysis. Clinically, the major features of Brooke‐Spiegler syndrome include the presence of heterogeneous skin tumors and wide inter‐ and intra‐familial phenotypic variability. Histopathologically, both cylindromas and trichoepitheliomas were found in affected individuals. Mutations or loss of heterozyg... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5401991 Sat, 12 Nov 2011 05:00:00 +0100 5401991 http://www.medworm.com/index.php?rid=5401990&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01805.x We report two additional cases of hybrid schwannoma/ perineurioma, one of which occurred after irradiation. Patient 1 was that of a 33‐year‐old man presented with a 2.8‐cm dermal tumor on his left lower leg. Patient 2 was that of an 89‐year‐old woman with a history of uterine carcinoma treated by surgery and radiation therapy at the age of 35. She presented with a 1.2 × 1.0 cm dermal tumor on her left mons pubis with multiple coincidental basal‐cell carcinomas around it. Both tumors were microscopically well circumscribed but unencapsulated and situated in the dermis and adipose tissue and showed a vague storiform and lamellar pattern. Cytologically, both tumors contained two‐cell populations, i.e. spindled cells with plump nuclei, which were positive for S‐100 protein and... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5401990 Sat, 12 Nov 2011 05:00:00 +0100 5401990 http://www.medworm.com/index.php?rid=5390973&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01818.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5390973 Thu, 10 Nov 2011 18:29:17 +0100 5390973 http://www.medworm.com/index.php?rid=5390974&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01804.x We present the case of a 60‐year‐old male with known stage IA mycosis fungoides (MF) who developed a suspicious tumor within a pre‐existing lymphomatous plaque of the right forearm. Microscopy revealed an unusual mixed fibrohistiocytic proliferation as well as atypical intraepidermal and dermal lymphocytes. There was no evidence of large‐cell transformation. Histopathological, immunohistochemical and clinical clues suggest this lesion might not have represented a dermatofibroma, but rather a hitherto unreported dermatofibroma‐like process arising within a lesion of MF. The potential impact of this atypical lesion on the prognosis and clinical management of this patient highlights the importance of recognizing unusual clinical presentations of more common, benign lesions within th... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5390974 Tue, 08 Nov 2011 05:00:00 +0100 5390974 http://www.medworm.com/index.php?rid=5366913&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01822.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5366913 Fri, 04 Nov 2011 02:36:44 +0100 5366913 http://www.medworm.com/index.php?rid=5366912&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01781.x Conclusions: Our results confirm increased expression of granzyme B and perforin in oral LP lesions as compared to cutaneous LP. The increased expression suggests a relationship with the clinical behavior of the disease.Lage D, Pimentel VN, Soares TCB, Souza EM, Metze K, Cintra ML. Perforin and granzyme B expression in oral and cutaneous lichen planus – a comparative study. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5366912 Fri, 04 Nov 2011 02:36:33 +0100 5366912 http://www.medworm.com/index.php?rid=5366911&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01790.x Angiosarcomas may be primary in the skin, primary in soft tissue or viscera, or secondary to irradiation. All angiosarcomas have a poor prognosis. Taxanes may have efficacy in the treatment of angiosarcoma. Expression of TLE3 has been associated with improved outcome in taxane‐treated breast cancers. We studied a series of angiosarcoma with TLE3 immunohistochemistry. Cases of angiosarcoma (98 total cases; 37 cutaneous, 48 soft tissue/visceral and 13 post‐irradiation) were retrieved and follow up was obtained. Tumors were classified as ‘vasoformative’, ‘spindled’, ‘epithelioid’ and ‘mixed’. TLE3 immunohistochemistry was performed. Statistical analyses were performed. Patients (50 males and 48 females) had a median age of 60.2 years. Tumors had a median size 7.5 cm and we... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5366911 Fri, 04 Nov 2011 02:36:30 +0100 5366911 http://www.medworm.com/index.php?rid=5366910&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01798.x Conclusions: Aberrant expression of Melan‐A and MART‐1 in AFX and undifferentiated pleomorphic sarcoma of the skin represents an important diagnostic pitfall with potential for misdiagnosis as melanoma. Melan‐A expression limited to tumor giant cells, in the absence of S‐100 positivity, is a helpful diagnostic feature.Thum C, Hollowood K, Birch J, Goodlad JR, Brenn T. Aberrant Melan‐A expression in atypical fibroxanthoma and undifferentiated pleomorphic sarcoma of the skin. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5366910 Fri, 04 Nov 2011 02:36:29 +0100 5366910 http://www.medworm.com/index.php?rid=5366909&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01809.x Cutaneous myeloid sarcoma is often challenging to diagnose based solely upon histopathological features. Although immunohistochemistry can aid in its diagnosis, specific markers have not been clearly identified. We evaluated the utility of immunohistochemical markers in 57 cutaneous myeloid sarcoma cases. In addition to classical markers (CD117, CD163, CD34, myeloperoxidase and lysozyme), we used CD33 and CD14, recently described markers in paraffin‐embedded tissue samples, and Kruppel‐like factor 4 (KLF‐4), a novel monocytic marker. Our results show that lysozyme was expressed in 91%, CD33 in 60%, myeloperoxidase in 54%, CD34 in 39% and CD117 in 36% of cases. An antibody panel that included lysozyme, CD117 and CD33 identified all cases. The monocytic markers CD14, KLF‐4 and CD163 ... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5366909 Fri, 04 Nov 2011 02:36:27 +0100 5366909 http://www.medworm.com/index.php?rid=5366908&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01821.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5366908 Fri, 04 Nov 2011 02:36:26 +0100 5366908 http://www.medworm.com/index.php?rid=5366907&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01820_2.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5366907 Fri, 04 Nov 2011 02:36:25 +0100 5366907 http://www.medworm.com/index.php?rid=5366900&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01808.x Amelanotic melanoma can have a varied appearance both clinically and microscopically. Here, we present our experiences with 75 cases of amelanotic melanoma defined clinically as a non‐pigmented lesion and histopathologically as a tumor lacking significant melanization. We evaluated microscopic features such as morphology, mitotic count, nuclear atypia and presence of solar elastosis. Our amelanotic melanomas exhibited the following morphology: epitheloid (72%), spindled (18.7%) or desmoplastic (5.3%). In addition, we obtained patient information and clinical presentations on most of the cases (74/75; 98.7%) and follow‐up data on 40% (30/75) of the cases. The majority of amelanotic melanomas in men were found on the trunk (13/45; 29%), head and neck (12/45; 26.7%), and lower limb (13/45... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5366900 Fri, 04 Nov 2011 02:36:01 +0100 5366900 http://www.medworm.com/index.php?rid=5366902&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01799.x Subungual melanoma commonly presents with solitary longitudinal melanonychia. Herein, we report the case of a patient with subungual melanoma who developed involvement of three digits by three independent primary melanomas. A 98‐year‐old male patient presented with a two‐year history of longitudinal melanonychia on three different fingernails. Histopathologically, all three lesions were proved to be melanoma. To our knowledge, this is the first reported case in which three subungual melanomas developed in one patient. Our case indicates that that not all examples of multiple longitudinal melanonychia represent benign lesions.Liu Y, Wang L. The rare occurrence of three subungual melanomas in one patient. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5366902 Thu, 03 Nov 2011 04:00:00 +0100 5366902 http://www.medworm.com/index.php?rid=5366901&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01806.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5366901 Thu, 03 Nov 2011 04:00:00 +0100 5366901 http://www.medworm.com/index.php?rid=5366905&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01789.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5366905 Fri, 28 Oct 2011 04:00:00 +0100 5366905 http://www.medworm.com/index.php?rid=5366904&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01792.x Scedosporium apiospermum, the asexual stage of Pseudoallescheria boydii, is a fungus ubiquitous in soil as well as organically polluted areas, where nitrogen‐containing compounds are abundant. It is an emerging opportunistic pathogen that can range from cutaneous to disseminated infection and can be fatal within months of diagnosis. Here we present a case of disseminated S. apiospermum infection with cutaneous manifestations in a 59‐year‐old woman with myelodysplastic syndrome, in remission from chronic lymphocytic leukemia, presented with pneumonia and deteriorating mental status. An X‐ray computed tomography scan showed three non‐contrast‐enhancing hypodensities affecting the brain. Many erythematous, indurated skin lesions, measuring 3–5 mm in diameter, were noted on her c... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5366904 Fri, 28 Oct 2011 04:00:00 +0100 5366904 http://www.medworm.com/index.php?rid=5366903&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01794.x We report an example of MCC with heterologous rhabdomyosarcomatous differentiation, the third such case to date, with emphasis on its distinction from fusion‐negative alveolar rhabdomyosarcoma. The role of immunohistochemistry for Merkel cell polyomavirus large T‐antigen in this differential diagnosis is emphasized.Adhikari LA, McCalmont TH, Folpe AL. Merkel cell carcinoma with heterologous rhabdomyoblastic differentiation: the role of immunohistochemistry for Merkel cell polyomavirus large T‐antigen in confirmation. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5366903 Fri, 28 Oct 2011 04:00:00 +0100 5366903 http://www.medworm.com/index.php?rid=5263355&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01803.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5263355 Thu, 29 Sep 2011 18:06:11 +0100 5263355 http://www.medworm.com/index.php?rid=5263354&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01776.x We present a case of hidradenitis occurring in a patient after chemotherapy for acute myeloid leukemia (AML) in the setting of profound neutropenia. Neutrophilic eccrine hidradenitis (NEH) presents as tender erythematous papules and plaques and is often associated with chemotherapy for AML. NEH is postulated to be due to toxic injury to the sweat glands followed by neutrophilic inflammation. Alternatively, some hypothesize that NEH represents a primary neutrophilic process. Our patient's clinical presentation was similar to previously reported cases of NEH; however, degenerative changes of the sweat ducts were noted on microscopy without neutrophilic inflammation. She had fewer than 0.01 thousand neutrophils per microliter for 4 days preceding the biopsy. At the same time, a separate area ... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5263354 Thu, 29 Sep 2011 18:05:59 +0100 5263354 http://www.medworm.com/index.php?rid=5263353&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01779.x CD123‐positive plasmacytoid dendrocytes are prominent in the infiltrate of discoid lupus erythematosus (LE). We hypothesized that these cells would also be present in hypertrophic LE and would aid in the histopathologic distinction from squamous cell carcinoma (SCC) and hypertrophic actinic keratosis (AK). Five cases of hypertrophic LE and 10 cases each of SCC and hypertrophic AK were stained with CD123. A heavy band of CD123‐positive cells was present at the epidermal–dermal junction in all cases of hypertrophic LE, and only single or rare scattered clusters of CD123‐positive cells were seen in SCC and actinic keratoses. The pattern of CD123 staining can be a useful feature to distinguish hypertrophic LE from SCC and hypertrophic AK.Ko CJ, Srivastava B, Braverman I, Antaya RJ, McN... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5263353 Thu, 29 Sep 2011 18:05:54 +0100 5263353 http://www.medworm.com/index.php?rid=5263352&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01780.x Conclusion: We showed that cytoplasmic laminin‐5 expression should not be used as a criterion of malignancy and is not useful in distinguishing pseudocarcinomatous hyperplasia from microinvasive and well‐differentiated SCC.dos Santos AM, Carneiro FP, Queiroz AJR, Damasceno EAM, de Castro TMML, de Amorim RFB, Takano GHS, Junqueira MIMB, de Magalhães AV. Expression of laminin‐5 γ2 chain in cutaneous pseudocarcinomatous hyperplasia. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5263352 Thu, 29 Sep 2011 18:05:48 +0100 5263352 http://www.medworm.com/index.php?rid=5263351&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01778.x Conclusions: The findings shown here, including the association between myopericytomas and arterial IT, the incorporation of the latter into the tumor and the similar phenotype of their respective myoid and myointimal cells, support a close relationship between these processes. Histogenically, the pericytes of the penetrating neovasculature originating from the attached venules and veins may contribute to both lesions.Díaz‐Flores L, Gutiérrez R, García MP, Álvarez‐Argüelles H, Díaz‐Flores L Jr, Madrid JF. Myopericytoma and arterial intimal thickening: the relationship between myopericytes and myointimal cells. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5263351 Thu, 29 Sep 2011 18:05:45 +0100 5263351 http://www.medworm.com/index.php?rid=5263350&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01802.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5263350 Thu, 29 Sep 2011 18:05:43 +0100 5263350 http://www.medworm.com/index.php?rid=5263349&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01801_2.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5263349 Thu, 29 Sep 2011 18:05:41 +0100 5263349 http://www.medworm.com/index.php?rid=5198447&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01793.x We report here an additional patient with the granulomatous variant of PPPD and elaborate on this entity in the context of existing information in the literature.MacQuarrie EK, Pasternak S, Torok M, Veerassamy S, Walsh NMG. Persistent pigmented purpuric dermatitis: granulomatous variant. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5198447 Thu, 08 Sep 2011 04:37:59 +0100 5198447 http://www.medworm.com/index.php?rid=5198452&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01782.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5198452 Tue, 06 Sep 2011 23:00:00 +0100 5198452 http://www.medworm.com/index.php?rid=5198451&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01791.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5198451 Tue, 06 Sep 2011 23:00:00 +0100 5198451 http://www.medworm.com/index.php?rid=5198450&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01795.x We present this case to promote the recognition of TNFα inhibitor‐induced sarcoidosis and to illustrate the wide clinicopathologic differential of sarcoidal type granulomas.Burns AM, Green PJ, Pasternak S. Etanercept‐induced cutaneous and pulmonary sarcoid‐like granulomas resolving with adalimumab. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5198450 Tue, 06 Sep 2011 23:00:00 +0100 5198450 http://www.medworm.com/index.php?rid=5198449&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01784.x This report details a case of an agminated cellular neurothekeoma occurring on the nose of a 28‐year‐old man. Recognition of multiple localized eruptive lesions of cellular neurothekeoma is important in order to facilitate correct diagnosis and avoid unnecessary treatment.Padgett SN, Walsh SN, Kory MC, Argenyi ZB. Agminated cellular neurothekeoma. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5198449 Tue, 06 Sep 2011 23:00:00 +0100 5198449 http://www.medworm.com/index.php?rid=5198448&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01787.x We report a 28 year‐old man with a two‐month history of scrotal burning and itching associated with the development of multiple thin red plaques with distinct elevated borders and a pebbled appearance. Histopathological examination revealed psoriasiform acanthosis and multiple cornoid lamellae, which is consistent with a diagnosis of porokeratosis ptychotropica. Our patient's presentation may represent a distinct variant with clinical features of verrucous porokeratosis and histopathological features of porokeratosis ptychotropica which may suggest that the finding of multiple cornoid lamellae is not unique to porokeratosis ptychotropica.Wanat KA, Gormley RH, Bennett DD, Kovarik CL. Genitogluteal porokeratosis involving the scrotum: an unusual presentation of an uncommon disease. (Sour... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5198448 Tue, 06 Sep 2011 23:00:00 +0100 5198448 http://www.medworm.com/index.php?rid=5186246&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01786.x Myxomas of the ear are extremely uncommon, especially in young children. A 23‐month‐old girl born to a family with known Carney complex, a condition that predisposes to multiple myxomas, presented with a large, cauliflower‐like mass located on the back of her right ear. Histopathologically, the lesion was composed of scattered spindle‐shaped or stellate cells with abundant associated mucin and a very sparse inflammatory infiltrate containing lymphocytes and neutrophils. The patient was a carrier of a protein kinase A regulatory subunit 1A (PRKAR1A) mutation; PRKAR1A mutations cause Carney complex in most patients with this rare disorder. This is the earliest presentation of an ear lobe myxoma reported in the literature.Briassoulis G, Quezado M, Lee C‐CR, Xekouki P, Keil M, Strata... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5186246 Sat, 03 Sep 2011 19:35:22 +0100 5186246 http://www.medworm.com/index.php?rid=5164983&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01797.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5164983 Sat, 27 Aug 2011 19:57:50 +0100 5164983 http://www.medworm.com/index.php?rid=5164982&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01796.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5164982 Sat, 27 Aug 2011 19:57:37 +0100 5164982 http://www.medworm.com/index.php?rid=5164981&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01775_2.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5164981 Sat, 27 Aug 2011 19:57:37 +0100 5164981 http://www.medworm.com/index.php?rid=5149049&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01777.x A cutaneous infiltrate composed of plasmacytoid dendritic cells may occasionally occur in a patient suffering from a myeloid neoplasm. To date, the clinical and pathological features associated with this event remains poorly characterized. Herein, we report a patient with acute myeloid leukemia who developed pruritic papules or erythematous plaques scattered on the skin. Microscopic examination showed a dermal infiltrate rich in plasmacytoid dendritic cells expressing CD4, CD43, CD68, granzyme B, CD123, CD303 [blood dendritic cell antigen 2 (BDCA‐2)], CD2‐associated protein (CD2AP) and T‐cell leukemia/lymphoma oncogene 1 (TCL1). Our observation illustrates further that cutaneous lesions associated with some myeloid neoplasms, especially those featuring a monocytic component, may be c... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5149049 Wed, 24 Aug 2011 20:39:55 +0100 5149049 http://www.medworm.com/index.php?rid=5149059&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01755.x We describe a 53‐year‐old man in good general health who presented with an 8‐month history of progressive gray hyperpigmentation of the face. He denied using any prescription medications; however, he admitted to taking a herbal supplement. Clinically, the differential diagnosis included hemochromatosis, Wilson's disease and hyperpigmentation secondary to supplement use. Punch biopsies from the left forehead and preauricular region showed heavily sun‐damaged skin with a minimal inflammatory infiltrate. Closer inspection, however, revealed minute scattered black/brown particles distributed in the basement membrane zone of eccrine and sebaceous glands. Similar particles were also present in hair follicles, blood vessels and arrector pili muscles. The particles did not stain with Gomor... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5149059 Mon, 22 Aug 2011 23:00:00 +0100 5149059 http://www.medworm.com/index.php?rid=5149058&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01757.x We report the clinical course, histopathology and genetic analysis of a 69‐year‐old woman with likely hematogenous spread of cutaneous neuroendocrine carcinoma manifesting as a single metastatic lesion to a distant cutaneous site. Although the possibility of two cutaneous primary MCCs was considered, array comparative genomic hybridization (aCGH) identified identical distal amplification of a region of chromosome 12p, and synchronous loss of chromosomes 8p and 17p, effectively ruling out the possibility of independent primaries. We propose that this represents a primary cheek MCC with rapid, isolated cutaneous metastasis to the contralateral ankle via hematogenous spread. The distinction between a second primary MCC and a distant cutaneous metastasis clearly has important implications ... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5149058 Mon, 22 Aug 2011 23:00:00 +0100 5149058 http://www.medworm.com/index.php?rid=5149057&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01765.x Conclusions: While MCPyV, HPyV6, and HPyV7 are part of normal skin flora and show a high degree of sequence similarity, there is no evidence of an association between HPyV6 and HPyV7 and MCC in this case series. This result argues against a role for HPyV6 and HPyV7 in the pathogenesis of MCPyV‐negative MCC.Duncavage EJ, Pfeifer JD. Human polyomaviruses 6 and 7 are not detectable in Merkel cell polyomavirus‐negative Merkel cell carcinoma. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5149057 Mon, 22 Aug 2011 23:00:00 +0100 5149057 http://www.medworm.com/index.php?rid=5149056&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01758.x We report a 51‐year‐old woman with cutaneous involvement by extranodal NK/T‐cell lymphoma (TCL) of the colon that microscopically mimicked mycosis fungoides (MF). She had a history of fever of unknown origin for 2 months and then developed multiple erythematous papules on her trunk and extremities. A skin biopsy revealed superficial infiltration by atypical small to medium‐sized lymphocytes with epidermotropism and Pautrier collections. Immunohistochemical studies showed expression of CD3 and TIA‐1 with lack of expression (double negative) of CD4 and CD8. Initially, we reported the diagnosis as MF, cytotoxic variant. Thereafter, computerized tomography scan incidentally identified a colonic mass. A colonic biopsy revealed infiltration of atypical lymphoid cells with the same morp... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5149056 Mon, 22 Aug 2011 23:00:00 +0100 5149056 http://www.medworm.com/index.php?rid=5149055&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01761.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5149055 Mon, 22 Aug 2011 23:00:00 +0100 5149055 http://www.medworm.com/index.php?rid=5149054&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01788.x Conclusions: At present, the pathogenesis of melanoma developing in a tattoo is unknown. Mere coincidence cannot be ruled out. However, trauma, ultraviolet light exposure, a photoallergic effect, or an inflammatory reaction may promote malignant transformation. Clinicians and histopathologists should be aware of the clinical and pathological features if they are to make a correct diagnosis.Varga E, Korom I, Varga J, Kohán J, Kemény L, Oláh J. Melanoma and melanocytic nevi in decorative tattoos: three case reports. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5149054 Mon, 22 Aug 2011 23:00:00 +0100 5149054 http://www.medworm.com/index.php?rid=5149053&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01760.x Conclusions: The histopathology of GF and EED is very similar and overlapping. The presence of a Grenz zone and patterned fibrosis does not distinguish the two diseases. However, granulomatous nodules are only seen in EED, and a predominance of eosinophils in the infiltrate favors a diagnosis of GF.Ziemer M, Koehler MJ, Weyers W. Erythema elevatum diutinum – a chronic leukocytoclastic vasculitis microscopically indistinguishable from granuloma faciale? (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5149053 Mon, 22 Aug 2011 23:00:00 +0100 5149053 http://www.medworm.com/index.php?rid=5149052&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01768.x Conclusions: CD10 is consistently expressed by AFX. However, CD10 is also often strongly expressed by sSCC. Positive staining with p63 favors a diagnosis of sSCC. An immunohistochemical battery useful for distinguishing AFX from sSCC may include CD10, p63 and two cytokeratin markers. However, CD10 alone should not be relied upon in the distinction of these entities.Wieland CN, Dyck R, Weenig RH, Comfere NI. The role of CD10 in distinguishing atypical fibroxanthoma from sarcomatoid (spindle cell) squamous cell carcinoma. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5149052 Mon, 22 Aug 2011 23:00:00 +0100 5149052 http://www.medworm.com/index.php?rid=5149051&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01769.x We describe another case involving a 40‐year old male who developed histiocytic sarcoma in his right thigh 4 years after the diagnosis of grade 1 follicular lymphoma in the left neck. The two neoplasms were morphologically and immunophenotypically different but had identical immunoglobulin heavy chain gene and bcl‐2 gene rearrangements, as demonstrated by polymerase chain gene reaction analysis, and the presence of t(14;18)(q32;q21) translocation was confirmed via fluorescence in situ hybridization (FISH) analysis. Because of spindle cell morphology and focal S‐100 positivity, malignant peripheral nerve sheath tumor and melanoma diagnoses were made initially and extensive workup was required to discover the correct diagnosis. Lineage transdifferentiation can occur in mature lymphoid ... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5149051 Mon, 22 Aug 2011 23:00:00 +0100 5149051 http://www.medworm.com/index.php?rid=5149050&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01774.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5149050 Mon, 22 Aug 2011 23:00:00 +0100 5149050 http://www.medworm.com/index.php?rid=5112287&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01764.x Conclusions: The inclusion bodies described herein bear no resemblance to other cytoplasmic inclusion bodies previously described in melanocytic lesions. There is no discernible relationship to melanosomes by ultrastructural analysis. We postulate a relationship with dysfunction of ubiquitin‐mediated protein degradation occurring in melanocytes.Shon W, Wada DA, Gibson LE, Flotte TJ, Scheithauer BW. Distinctive eosinophilic cytoplasmic inclusion bodies in melanocytic nevi: an immunohistochemical and ultrastructural study. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5112287 Thu, 11 Aug 2011 06:57:46 +0100 5112287 http://www.medworm.com/index.php?rid=5099421&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01756.x We present a 48‐year‐old man with a 2 × 3 cm violaceous to hyperpigmented, non‐blanching, polygonal patch on the neck. Histopathology showed focal epidermal atrophy, irregularly distributed junctional nests and a lichenoid infiltrate with colloid bodies. Immunoperoxidase studies revealed occasional pan‐cytokeratin and MART‐1/Melan‐A‐positive staining in nests as well as focal S‐100 protein‐positive cells. Importantly, the majority of nests showed numerous cells positive for MiTF and SOX10 (>2 cells/nest and some the majority of cells). This combined staining pattern confounds the above‐described immunohistochemical distinction between pseudo and true melanocytic nests. Clinically felt to represent unilateral lichen planus pigmentosus/erythema dyschromicum perstans a... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5099421 Sat, 06 Aug 2011 21:07:47 +0100 5099421 http://www.medworm.com/index.php?rid=5072439&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01766.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5072439 Fri, 29 Jul 2011 16:46:46 +0100 5072439 http://www.medworm.com/index.php?rid=5072442&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01759.x Conclusions: The clinicopathological significance of the two histopathological patterns remains unclear, because the number of reported cases is limited. It is possible that these two histopathological patterns of carcinoma have different histogenetic and prognostic implications, but no definitive conclusions can be made until further studies of a larger number of cases can be completed.Misago N, Toda S, Narisawa Y. Two histopathologic patterns of well‐differentiated extraocular sebaceous carcinoma. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5072442 Thu, 28 Jul 2011 23:00:00 +0100 5072442 http://www.medworm.com/index.php?rid=5072441&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01762.x Conclusions: TWEAK is a constitutively expressed epidermal protein whose downregulation might be an early indicator of disturbed differentiation or pathologic proliferation of keratinocytes that accompany inflammatory and neoplastic skin diseases.Peternel S, Manestar‐Blažić T, Brajac I, Prpić‐Massari L, Kaštelan M. Expression of TWEAK in normal human skin, dermatitis and epidermal neoplasms: association with proliferation and differentiation of keratinocytes. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5072441 Thu, 28 Jul 2011 23:00:00 +0100 5072441 http://www.medworm.com/index.php?rid=5072440&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01763.x Conclusions: These results show that Melan‐A significantly overestimates the density of melanocytes within dermatoheliotic skin. Compared to other tested stains, nuclear staining MiTF allowed greater distinction of melanocytes from keratinocytes with melanized cytoplasm. These findings indicate that MiTF is a superior marker for quantification of melanocytes in the evaluation of subtle intraepidermal melanocytic proliferations and in the differential diagnosis of solar lentigo.Kim J, Taube J, McCalmont TH, Glusac EJ. Quantitative comparison of MiTF, Melan‐A, HMB‐45 and Mel‐5 in solar lentigines and melanoma in situ. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5072440 Thu, 28 Jul 2011 23:00:00 +0100 5072440 http://www.medworm.com/index.php?rid=5065408&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01773.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5065408 Wed, 27 Jul 2011 05:18:15 +0100 5065408 http://www.medworm.com/index.php?rid=5065407&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01767.x This article reviews the current nomenclature, emerging concepts, and differential diagnosis of these evolving entities.Lewin MR, Montgomery EA, Barrett TL. New or unusual dermatopathology tumors: a review. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5065407 Wed, 27 Jul 2011 05:18:05 +0100 5065407 http://www.medworm.com/index.php?rid=5065406&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01771.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5065406 Wed, 27 Jul 2011 05:18:05 +0100 5065406 http://www.medworm.com/index.php?rid=5065405&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01770_2.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5065405 Wed, 27 Jul 2011 05:18:04 +0100 5065405 http://www.medworm.com/index.php?rid=5043073&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01752.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5043073 Thu, 21 Jul 2011 17:32:43 +0100 5043073 http://www.medworm.com/index.php?rid=5043072&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01749.x Conclusions: CD34 may not be a tricholemmal lineage‐specific antigen, but may be related to certain functions of the cells.Misago N, Toda S, Narisawa Y. CD34 expression in human hair follicles and tricholemmoma: a comprehensive study. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5043072 Thu, 21 Jul 2011 17:32:36 +0100 5043072 http://www.medworm.com/index.php?rid=5043071&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01751.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5043071 Thu, 21 Jul 2011 17:32:36 +0100 5043071 http://www.medworm.com/index.php?rid=5043070&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01748_2.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5043070 Thu, 21 Jul 2011 17:32:35 +0100 5043070 http://www.medworm.com/index.php?rid=5032269&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01744.x We present a case of GPPD in a Caucasian, North American Ashkenazi Jewish woman involving the thighs, back, forearms and wrists with concomitant non‐granulomatous PPD of the shins. She presented with an asymptomatic, spreading, cayenne pepper‐like rash. This rash intermittently involved the lower extremities and back for 15 years, but now involves the thighs with accompanying pink papules on the back, wrists and forearms. Histopathology of the thigh and back lesions revealed superficial lichenoid granulomatous dermatitis with palisading lymphocytes and focal interface changes. Extravasated erythrocytes were seen, but vasculitis was absent. No lymphocytic atypicality was noted and T‐cell gene rearrangement studies were non‐clonal. This is the second reported case of GPPD in a non‐... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5032269 Wed, 13 Jul 2011 23:00:00 +0100 5032269 http://www.medworm.com/index.php?rid=5032268&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01736.x We present six cases (five females, one male; aged 26–81 years) of dacryops, also known as lacrimal gland cyst, all of which occurred at the outer canthal area below the upper eyelid. All presented clinically as a painless cystic lesion that was white to blue in color. Microscopically, in addition to typical features of dacryops, which is characterized by a partially cystic proliferation that includes a double layer of columnar to cuboidal epithelial cells associated with lobules of lacrimal gland tissue, we identified evidence of apocrine secretion (i.e. apical snouts projecting into the lumen), either in the cystic component of the proliferation or in contiguous lacrimal duct, in all cases. One example was unusual. It manifested, in addition to typical cyst formation, with areas of duc... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5032268 Wed, 13 Jul 2011 23:00:00 +0100 5032268 http://www.medworm.com/index.php?rid=5032267&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01738.x A 57‐year‐old man status post several myocardial infarcts and heart transplantation presented with a slowly growing violaceous plaque on his lateral left knee at the site of prior minor trauma. A biopsy revealed a suppurative dermatitis with associated pseudocarcinomatous epithelial hyperplasia. There were multiple non‐pigmented eosinophilic organisms with clear cytoplasmic halos within the infiltrate. A methenamine silver stain showed round to ovoid organisms of slightly variable size. Rare uni‐polar budding, some of which was broad based, was apparent. A few short hyphae with indeterminate septa were also noted. Fontana‐Masson, mucicarmine, Alcian blue and Fite stains were all negative. These findings suggested a diagnosis of blastomycosis. However, a fungal culture grew coloni... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5032267 Wed, 13 Jul 2011 23:00:00 +0100 5032267 http://www.medworm.com/index.php?rid=5032266&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01740.x This article discusses both the nosology and histopathological spectrum of these important soft tissue sarcomas, their aggressive and recurrent nature and their association with radiation therapy.Bandino JP, Norton SA, Aldrich SL, Wisco OJ, Hodson DS, Murchland MR, Grande DJ. Low‐grade myxofibrosarcoma presenting at the site of prior high‐grade disease. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5032266 Wed, 13 Jul 2011 23:00:00 +0100 5032266 http://www.medworm.com/index.php?rid=5032265&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01741.x We report the case of a 23‐year‐old man with a history of HSTL that was presumed to be in remission who presented with a solitary cutaneous nodule. Skin biopsy showed an atypical lymphocytic infiltrate arranged in a perivascular and periappendageal pattern with associated vacuolar epidermal interface change. The constituent T cells expressed CD2, CD3, CD7, CD8, β‐F1, γδ T‐cell receptor, Tia‐1 and granzyme B. The cells lacked the expression of CD4, CD5 and CD56. Fluorescence in situ hybridization (FISH) showed a characteristic chromosomal abnormality, namely isochromosome 7q, which confirmed the diagnosis of cutaneous HSTL. On restaging his disease, widespread progression was noted. To our knowledge, this report provides the first detailed account of cutaneous involvement by HS... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5032265 Wed, 13 Jul 2011 23:00:00 +0100 5032265 http://www.medworm.com/index.php?rid=5032264&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01743.x We report a case of CEAN that had remained stable for more than 30 years on the chest wall of a woman with a history of breast cancer. The lesional cells were epithelioid in appearance and positive for estrogen receptor (ER), raising suspicion for breast carcinoma. However, the cells were positive for CD31, CD34, D2‐40 and EMA (epithelial membrane antigen); they were negative for cytokeratins, carcinoembryonic antigen (CEA), CD1a, gross cystic disease fluid protein (GCDFP‐15), S‐100, a melanocytic cocktail, HHV‐8 and progesterone receptor. The histologic and immunohistochemical features, including a low proliferation index (10% by Ki‐67), helped to distinguish this lesion from carcinoma and other vascular lesions. This is the most comprehensive immunohistochemical profile reporte... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5032264 Wed, 13 Jul 2011 23:00:00 +0100 5032264 http://www.medworm.com/index.php?rid=5032263&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01747.x Conclusion: Frequent EMA expression in EFH represents an unexpected finding and constitutes a potential diagnostic pitfall. Although of uncertain significance, this finding, when combined with established morphologic differences, raises the possibility that EFH is unrelated to classic FH.Doyle LA, Fletcher CDM. EMA positivity in epithelioid fibrous histiocytoma: a potential diagnostic pitfall. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5032263 Wed, 13 Jul 2011 23:00:00 +0100 5032263 http://www.medworm.com/index.php?rid=5032262&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01742.x We describe a case of a 17‐year‐old woman who presented with a 2‐day history of erythematous patches involving her bilateral knees and tender, scattered red‐brown nodules involving her bilateral anterior shins. She was seen during a hospitalization for emergent cesarean section and her hospital course was complicated by HELLP syndrome (defined by the presence of hemolysis, elevated liver enzymes, low platelet count), acute fatty liver of pregnancy and pancreatitis. The characteristic histopathologic findings, including ghost cells, fat necrosis and granular basophilic material with dystrophic calcification, appear in later lesions. In early lesions, as was shown in this case, a neutrophilic subcutaneous infiltrate raises a differential diagnosis including infection, subcutaneous Sw... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5032262 Wed, 13 Jul 2011 23:00:00 +0100 5032262 http://www.medworm.com/index.php?rid=5032261&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01746.x Conclusion: Dermal antigen‐presenting cells, including melanophages, seem to contain a diverse combination of molecules, representative of an immunologic process where these cells are engulfing both autoantigens and/or cellular debris in El Bagre‐EPF. Autoantibodies to discrete components of melanocytes were also identified; the clinical and immunologic significance of these findings remains unknown. Our work may provide a possible explanation of a darkened complexion in patients affected by endemic pemphigus foliaceus.Abreu Velez A M, Yi H, Googe PB Jr, Mihm MC Jr, Howard MS. Autoantibodies to melanocytes and characterization of melanophages in patients affected by a new variant of endemic pemphigus foliaceus. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5032261 Wed, 13 Jul 2011 23:00:00 +0100 5032261 http://www.medworm.com/index.php?rid=5032260&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01739.x Dermatomyofibroma represents a rare benign fibroblastic/ myofibroblastic cutaneous tumor that mostly occurs in young adult women. It has been seldom reported in pediatric patients. In this analysis, the clinical, histopathological and immunohistochemical findings of 12 dermatomyofibromas occurring in patients up to 16 years of age are compared with those reported in adults. Six patients were male and six were female. Nine lesions were located on the neck, two on the back and one involved the chest. The usual presentation was as an asymptomatic plaque composed of bland spindled cells arranged in dermal fascicles that were oriented parallel to the epidermis. Immunohistochemically, the lesional cells expressed calponin in 11 cases, smooth muscle actin in six and muscle‐specific actin in thr... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5032260 Wed, 13 Jul 2011 23:00:00 +0100 5032260 http://www.medworm.com/index.php?rid=5032259&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01745.x We report a case of an extra nuchal‐type fibroma in a 51‐year‐old male suspected to have attenuated familial adenomatous polyposis (Gardner's syndrome), who presented with a longstanding buttock mass excised due to enlargement and pain. Histopathologically, lobules of haphazard, hypocellular, hyalinized collagen bundles replaced the dermis and subcutis and entrapped nerve bundles, mimicking Morton neuroma. Ramifying nerve twigs found around larger nerve fascicles showed the co‐existence of traumatic neuroma. Elastic tissue stain revealed elastosis characterized by large, arborizing fibers lying between and within the hyalinized collagen bundles. Modified Masson's trichrome stain showed light blue staining of collagen bundles producing the hyalinized nodules with irregular, light re... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5032259 Wed, 13 Jul 2011 23:00:00 +0100 5032259 http://www.medworm.com/index.php?rid=5032258&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01750.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5032258 Wed, 13 Jul 2011 23:00:00 +0100 5032258 http://www.medworm.com/index.php?rid=5032257&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01754.x We present a brief review of the literature as well as two additional cases of FICRD. Case 1 is a 44‐year‐old man with an atrophic lateral back patch for several years. Chart review revealed a history of cardiac radiofrequency ablation and congenital heart disease with correction. Case 2 is a 64‐year‐old woman with an ulcerated, atrophic left flank plaque, with a history of mesenteric artery angiography and stent placement. In our two cases, as well as the cases in the literature, a diagnosis of FICRD is associated with key features. In the evaluation of a sclerosing process, chronic radiation dermatitis should be suspected histologically by the findings of ulceration, prominent telangiectasias, atypical stellate fibroblasts, absence of a lymphocytic infiltrate/inflammation and/or ... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5032257 Thu, 30 Jun 2011 23:00:00 +0100 5032257 http://www.medworm.com/index.php?rid=5001868&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01737.x We report a patient with PRP whose biopsies showed both herpes simplex infection and FAD. A complete understanding of the mechanism behind this eruption evolved gradually, aided in great measure by the histopathologic findings.Erdag G, Lockman D, Tromberg J, Cropley T, Patterson JW. A case of pityriasis rubra pilaris with associated focal acantholytic dyskeratosis complicated by Kaposi's varicelliform eruption. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=5001868 Thu, 30 Jun 2011 23:00:00 +0100 5001868 http://www.medworm.com/index.php?rid=4906643&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01735.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=4906643 Wed, 08 Jun 2011 16:28:57 +0100 4906643 http://www.medworm.com/index.php?rid=4906635&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01705.x Conclusions: Superficial ESFT appears to have a relatively favorable prognosis but further studies with additional series, a larger number of cases and more extensive follow‐up are necessary to confirm this statement.Machado I, Llombart B, Calabuig‐Fariñas S, Llombart‐Bosch A. Superficial Ewing's sarcoma family of tumors: a clinicopathological study with differential diagnoses. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=4906635 Wed, 08 Jun 2011 16:28:32 +0100 4906635 http://www.medworm.com/index.php?rid=4906642&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01713.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=4906642 Mon, 06 Jun 2011 23:00:00 +0100 4906642 http://www.medworm.com/index.php?rid=4906641&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01719.x We report the case of a 40‐year‐old female who presented with the onset of diffuse hyperpigmentation shortly after birth, which was followed by the widespread development of numerous 2–5 mm hypopigmented macules. Biopsy of the one of these macules revealed eosinophilic globular material in the papillary dermis with Congo red birefringence which also stained positively for high‐molecular weight cytokeratin. Electron microscopy confirmed the presence of 11 nm hollow fibrils, consistent with amyloid. Similar clinical changes were noted in a younger male sibling. Both patients also suffered from an unexplained neurological disorder characterized by atypical Parkinsonism, spasticity and motor weakness. This association has not been shown before and may represent a heretofore unreported ... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=4906641 Mon, 06 Jun 2011 23:00:00 +0100 4906641 http://www.medworm.com/index.php?rid=4906640&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01722.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=4906640 Mon, 06 Jun 2011 23:00:00 +0100 4906640 http://www.medworm.com/index.php?rid=4906639&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01727.x Conclusions: The use of dual TCR‐PCR analysis, that is, T‐cell clonality analysis in biopsy specimens from two different sites, serves as an adjunct to assist in distinguishing granulomatous inflammatory reactions from granulomatous T‐cell lymphoma, including granulomatous mycosis fungoides. The occasional finding of a T‐cell clone in a granulomatous dermatitis underscores the importance of clinicopathological correlation in daily diagnosis.Dabiri S, Morales A, Ma L, Sundram U, Kim YH, Arber DA, Kim J. The frequency of dual TCR‐PCR clonality in granulomatous disorders. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=4906639 Mon, 06 Jun 2011 23:00:00 +0100 4906639 http://www.medworm.com/index.php?rid=4906638&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01729.x Polypoid Spitz nevus represents a spitzoid melanocytic neoplasm that frequently has worrying and challenging histopathological details. Distinction from polypoid melanoma may not be straightforward. Two cases of polypoid Spitz nevus with striking histopathological features were studied. One case had prolonged follow up (Case 1) and one patient had undergone sentinel lymph node biopsy (Case 2), and fluorescence in situ hybridization (FISH) analysis was also completed (both cases). Follow up and genetic analysis of three control cases of polypoid melanoma is also presented. Our clinical and genetic results suggest that both the polypoid Spitz nevi were benign. The patients are alive with no evidence of disease. FISH analysis did not show abnormalities with probes tested. This is in sharp con... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=4906638 Mon, 06 Jun 2011 23:00:00 +0100 4906638 http://www.medworm.com/index.php?rid=4906637&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01730.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=4906637 Mon, 06 Jun 2011 23:00:00 +0100 4906637 http://www.medworm.com/index.php?rid=4906636&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01733.x We present two cases of verrucous hemangioma and discuss the clinicopathologic and immunohistochemical findings.Clairwood MQ, Bruckner AL, Dadras SS. Verrucous hemangioma: a report of two cases and review of the literature. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=4906636 Mon, 06 Jun 2011 23:00:00 +0100 4906636 http://www.medworm.com/index.php?rid=4879635&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01726.x We describe a patient with a primary cutaneous MALT lymphoma with unusual clinical features and an unusual immunophenotype. Conventional microscopy together with immunohistochemistry and in‐situ hybridization showed the presence of lymphoma in normal‐appearing and minimally erythematous skin as well as in clinically involved skin. Furthermore, at least two distinct clones were shown, one of which had κ‐light chain restriction, and the other of which had λ‐light chain restriction. This case represents a newly described clinical appearance of primary cutaneous MZL and shows that some patients may have more than one neoplastic clone.Edinger JT, Lorenzo CR, Breneman DL, Swerdlow SH. Primary cutaneous marginal zone lymphoma with subclinical cutaneous involvement and biclonality. (Sour... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=4879635 Tue, 31 May 2011 16:22:57 +0100 4879635 http://www.medworm.com/index.php?rid=4879640&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01708.x In conclusion, we clearly showed myofibroblastic differentiation in AFX by electron microscopy. We report also a case of AFX directly developing within a burn scar in the absence of actinic damage.Ito A, Yamada N, Yoshida Y, Morino S, Yamamoto O. Myofibroblastic differentiation in atypical fibroxanthomas occurring on sun‐exposed skin and in a burn scar: an ultrastructural and immunohistochemical study. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=4879640 Sun, 29 May 2011 23:00:00 +0100 4879640 http://www.medworm.com/index.php?rid=4879639&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01709.x We present two new cases of this entity and describe their clinical, histological and immunohistochemical features. CD20 is a highly specific B‐cell marker. However, it has been reported in a subset of normal T‐cells in peripheral blood and bone marrow of healthy individuals. This subset of T‐cells also expresses more often CD8 and g/d than the CD20‐negative T‐cells. Two main theories have been postulated to explain the expression of CD20 by neoplastic T‐cells. The first possibility is that these lymphomas develop from the CD20‐positive subset of normal T‐cells. The second theory regards CD20 as an activation marker. Prognostic implications and therapeutic options of T‐cell lymphomas with positivity for CD20 remain to be elucidated.Martin B, Stefanato C, Whittaker S, Robs... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=4879639 Sun, 29 May 2011 23:00:00 +0100 4879639 http://www.medworm.com/index.php?rid=4879638&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01718.x Conclusions: We confirmed that CD99 and CD10 are frequently expressed in AFX (65 and 85%, respectively) and that CD31 rarely stains positive (5%). The 50% positivity rate of D2‐40, in contrast with published evidence for its absence in melanoma, suggests that D2‐40 may be useful for distinguishing AFX from melanoma. Furthermore, because only one sample was positive for p75, we confirm that p75 is useful in differentiating AFX from spindle cell melanoma. We advocate adding p75 and D2‐40 to assist in differentiating AFX from melanoma.Bull C, Mirzabeigi M, Laskin W, Dubina M, Traczyc T, Guitart J, Gerami P. Diagnostic utility of low‐affinity nerve growth factor receptor (P 75) immunostaining in atypical fibroxanthoma. (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=4879638 Sun, 29 May 2011 23:00:00 +0100 4879638 http://www.medworm.com/index.php?rid=4879637&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01720.x We describe an 85‐year‐old man with myelodysplastic syndrome who presented with a reddish‐purple nodule with a surrounding erythematous plaque on his shin. Histopathologic examination revealed a dense diffuse infiltrate of large atypical cells in the reticular dermis, with ulceration and necrosis. Immunohistochemical studies showed positive staining with CD15, CD68 and myeloperoxidase of constituent large cells. Concurrently, there were branching and septate hyphae with occasional macroconidia‐like structures throughout the infiltrate. Cultures from this lesion grew Fusarium and Enterococcus, supporting the diagnosis: leukemia cutis with superinfection involving both Fusarium and Enterococcus. To our knowledge, this is a novel report of two separate infections occurring in a lesion... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=4879637 Sun, 29 May 2011 23:00:00 +0100 4879637 http://www.medworm.com/index.php?rid=4879636&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01721.x We report a case of a progressively enlarging abdominal mass with cutaneous involvement in an HIV‐infected, 4‐year‐old African girl in Malawi with clinical acquired immunodeficiency syndrome on highly active antiretroviral therapy. Analysis of an excisional specimen revealed a well‐differentiated leiomyosarcoma and subsequent studies revealed diffuse nuclear positivity for Epstein‐Barr virus early RNAs in lesional cells. We present a report of this case and provide a summary of the literature regarding SMTs in pediatric HIV‐infected patients. In addition, we draw attention to the cutaneous manifestations of SMTs in immunosuppressed populations. We highlight EBV‐related SMTs as a potential cutaneous complication of HIV infection in children and immunosuppressed patients popula... Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=4879636 Sun, 29 May 2011 23:00:00 +0100 4879636 http://www.medworm.com/index.php?rid=4866935&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01734.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=4866935 Fri, 27 May 2011 16:25:28 +0100 4866935 http://www.medworm.com/index.php?rid=4866934&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01735.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=4866934 Fri, 27 May 2011 16:25:27 +0100 4866934 http://www.medworm.com/index.php?rid=4866933&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01732.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=4866933 Fri, 27 May 2011 16:25:21 +0100 4866933 http://www.medworm.com/index.php?rid=4866932&cid=s_28441_32_f&fid=28441&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0560.2011.01731_2.x (Source: Journal of Cutaneous Pathology) Journal of Cutaneous Pathology journals http://www.medworm.com/rss/comments.php?id=4866932 Fri, 27 May 2011 16:25:20 +0100 4866932