Journal of Dermatological Science via MedWorm.com MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Journal of Dermatological Science' source. Mon, 15 Mar 2010 14:11:33 +0100 Announcements http://www.medworm.com/index.php?rid=3268000&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181110000411%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3268000 Sat, 13 Feb 2010 14:02:46 +0100 3268000 The papillary structure identified by a novel nail wound healing model in mice http://www.medworm.com/index.php?rid=3267999&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109003697%2Fabstract%3Frss%3Dyes The nails are located at the dorsal aspect of the fingers and toes . The function of nails is to protect, resist pressure on the digits, and detect certain sensations . Since nails are located at the periphery of the body, they are easily damaged or shed by external stimuli . Since nails play important role in the distal extremities, rapid healing of the damaged nail is desirable . (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3267999 Sat, 13 Feb 2010 14:02:46 +0100 3267999 Characterization of dendritic cells and macrophages in irritant contact dermatitis http://www.medworm.com/index.php?rid=3267998&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181110000253%2Fabstract%3Frss%3Dyes Irritant contact dermatitis (ICD) is a non-allergic inflammatory reaction of the skin caused by direct cytotoxic effects of irritant chemicals or physical agents. It is one of the most common cutaneous diseases . In the past, the pathogenesis of ICD was thought to be non-immunological while allergic contact dermatitis (ACD) was presumed immune mediated. Today, it has become increasingly accepted that the immune systems plays an important part in eliciting ICD . The current concept of ICD pathogenesis is that irritants cause disruption of skin barrier function and damage to keratinocytes. Consequently, a local inflammatory response is mounted . (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3267998 Sat, 13 Feb 2010 14:02:46 +0100 3267998 Follow up study of dermal hyaluronic acid injection by high frequency ultrasound and magnetic resonance imaging http://www.medworm.com/index.php?rid=3267997&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181110000022%2Fabstract%3Frss%3Dyes In the last few years, increasing use of injectable resorbable fillings has been reported for facial wrinkle treatment and for soft tissue augmentation of HIV-associated facial lipodystrophy . However, important practical information concerning the localization and subsequent diffusion of the injected product in skin tissues are poorly documented. Histological analysis has been previously used to compare different kinds of fillers , to evaluate remanescence of the injected material , or to observe the product placement at the injection site . Wang et al. have recently proposed a mechanism in which the filler-induced mechanical tension solicits local fibroblasts and activates collagen synthesis . (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3267997 Sat, 13 Feb 2010 14:02:45 +0100 3267997 Keratinocyte differentiation induced by calcium, phorbol ester or interferon-γ elicits distinct changes in the retinoid signalling pathways http://www.medworm.com/index.php?rid=3267996&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181110000034%2Fabstract%3Frss%3Dyes Conclusions: Retinoid signalling is profoundly altered upon differentiation of keratinocytes and the effects depend on how cellular differentiation is initiated. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3267996 Sat, 13 Feb 2010 14:02:45 +0100 3267996 Association of single nucleotide polymorphisms in the IL-12 (IL-12A and B) and IL-12 receptor (IL-12Rβ1 and β2) genes and gene–gene interactions with atopic dermatitis in Koreans http://www.medworm.com/index.php?rid=3267995&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109003624%2Fabstract%3Frss%3Dyes Conclusion: This study provides evidence for a significant interaction between the IL-12RB1 and IL-12RB2 genes that contribute to a 4-fold increased risk for developing ADe. In addition to the IL-12R interaction, we suggest that the IL-18 gene can significantly interact with the IL-12R gene to develop ADe. In addition to the interaction, the SNPs and haplotypes in the IL-12A and IL-12RB1 genes are independently and significantly associated with the AD phenotype, and especially with the ADe phenotype. This data may contribute to our understanding of AD genetic interactions and account for the additional risk of certain patients to develop AD. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3267995 Sat, 13 Feb 2010 14:02:45 +0100 3267995 Bidimensional analysis of desmoglein 1 distribution on the outermost corneocytes provides the structural and functional information of the stratum corneum http://www.medworm.com/index.php?rid=3267994&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181110000046%2Fabstract%3Frss%3Dyes Conclusion: We explored the distribution pattern of Dsg1 in the SC via a non-invasive investigation tool. Our findings indicate the significance of adhesion molecules in the formation and function of the SC, and suggest that adhesion molecules are one of the important elements in barrier formation in addition to corneocytes, which act as bricks, and intercellular lipids, which act as mortar. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3267994 Sat, 13 Feb 2010 14:02:45 +0100 3267994 Topical application of anti-angiogenic peptides based on pigment epithelium-derived factor can improve psoriasis http://www.medworm.com/index.php?rid=3267993&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109003727%2Fabstract%3Frss%3Dyes We examined the expression of PEDF in skin by immunohistochemical staining, immunoblotting, and RT-PCR. To identify potential PEDF peptides, we screened peptides derived from the proteolytic fragmentation of PEDF for their anti-proliferative action. Anti-psoriatic functions of these peptides were analyzed using a mouse graft model of psoriasis.Results: The specific low-molecular weight peptides (MW (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3267993 Sat, 13 Feb 2010 14:02:44 +0100 3267993 c-Maf and MafB transcription factors are differentially expressed in Huxley's and Henle's layers of the inner root sheath of the hair follicle and regulate cuticle formation http://www.medworm.com/index.php?rid=3267992&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109003739%2Fabstract%3Frss%3Dyes Conclusion: c-Maf and MafB are expressed in the IRS layers in a lineage-restricted manner and are involved in hair morphogenesis. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3267992 Sat, 13 Feb 2010 14:02:44 +0100 3267992 Inhibition of melanogensis by a novel origanoside from Origanum vulgare http://www.medworm.com/index.php?rid=3267991&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109003715%2Fabstract%3Frss%3Dyes Conclusion: Experimental data demonstrate that origanoside (1) causes depigmentation and may be useful for novel food additives and skin-whitening cosmetics. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3267991 Sat, 13 Feb 2010 14:02:44 +0100 3267991 Histological and transcriptional study of angiogenesis and lymphangiogenesis in uninvolved skin, acute pinpoint lesions and established psoriasis plaques: An approach of vascular development chronology in psoriasis http://www.medworm.com/index.php?rid=3267990&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109003685%2Fabstract%3Frss%3Dyes Conclusion: These data suggest that the expansion of lymphatic vessels occurs after blood vascular development in psoriasis. Expansion of BV in PP could be followed by vessel enlargement during progression to PSO, in parallel with a decreased VEGF-A 189/VEGF-A 121 balance in plaques. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3267990 Sat, 13 Feb 2010 14:02:44 +0100 3267990 Cutaneous consequences of inhibiting EGF receptor signaling in vivo: Normal hair follicle development, but retarded hair cycle induction and inhibition of adipocyte growth in EgfrWa5 mice http://www.medworm.com/index.php?rid=3267989&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109003636%2Fabstract%3Frss%3Dyes Conclusion: Our results suggest the presence of effective compensatory mechanisms in murine skin in vivo that ensure nearly normal epidermal and hair follicle keratinocyte function despite very low levels of EGFR-mediated signaling. Our unexpected findings of transiently reduced subcutaneous adipose tissue indicate a role for the EGFR in regulating subcutaneous fat. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3267989 Sat, 13 Feb 2010 14:02:43 +0100 3267989 CD147/basigin promotes progression of malignant melanoma and other cancers http://www.medworm.com/index.php?rid=3267988&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109003703%2Fabstract%3Frss%3Dyes Abstract: CD147/basigin, a transmembrane protein belonging to the immunoglobulin super family, was originally cloned as a carrier of Lewis X carbohydrate antigen. CD147 is strongly related to cancer progression; it is highly expressed by various cancer cells including malignant melanoma (MM) cells and it plays important roles in tumor invasiveness, metastasis, cellular proliferation, and in vascular endothelial growth factor (VEGF) production, tumor cell glycolysis, and multi-drug resistance (MDR). CD147 on cancer cells induces matrix metalloproteinase expression by neighboring fibroblasts, leading to tumor cell invasion. In a nude mouse model of pulmonary metastasis from MM, the metastatic potential of CD147-expressing MM cells injected into the tail vein is abolished by CD147 silencing. ... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3267988 Sat, 13 Feb 2010 14:02:43 +0100 3267988 Editorial Board http://www.medworm.com/index.php?rid=3267987&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181110000307%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3267987 Sat, 13 Feb 2010 14:02:43 +0100 3267987 Announcements http://www.medworm.com/index.php?rid=3213965&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181110000125%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3213965 Thu, 28 Jan 2010 14:12:55 +0100 3213965 Mutational survey of recessive dystrophic epidermolysis bullosa in Tunisian families unveils a spectrum of private, ethnic specific and world wide recurrent mutations http://www.medworm.com/index.php?rid=3213964&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109003594%2Fabstract%3Frss%3Dyes Dystrophic epidermolysis bullosa (DEB) is a group of inherited mechano-bullous disorders with a broad range of clinical severity characterized by blistering. Ultrastructurally, DEB shows abnormalities of the anchoring fibrils, which are composed of type VII collagen . On the basis of the mode of inheritance and the clinical manifestations, DEB is classified into 3 major forms: one dominant (DDEB) and two recessive (RDEB), the severe generalized RDEB subtype (RDEBsg) and “RDEB generalized other” (RDEB-O) which designates the other groups of generalized RDEB . All forms of DEB are known to be caused by mutations in the COL7A1 gene encoding type VII collagen. This gene consists of 118 exons, and over 300 COL7A1 mutations have been reported , most of them being family specific. (Source: Jo... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3213964 Thu, 28 Jan 2010 14:12:55 +0100 3213964 Prevalence of metabolic syndrome in Japanese psoriasis patients http://www.medworm.com/index.php?rid=3213963&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109003363%2Fabstract%3Frss%3Dyes Metabolic syndrome is a constellation of multiple risk factors including central obesity, dyslipidemia, glucose intolerance, and elevated blood pressure. The syndrome is associated with cardiovascular disease and type 2 DM , and non-alcoholic steatohepatitis (NASH) . Several reports indicate the association between psoriasis and DM, hypertension, obesity, and metabolic syndrome in Caucasian and Chinese psoriasis . Although we have shown the increased prevalence of obesity and adiposity in Japanese psoriasis , the incidence of DM, hypertension, cardiovascular disease, and the metabolic syndrome remains to be determined. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3213963 Thu, 28 Jan 2010 14:12:54 +0100 3213963 CD109 expression levels in malignant melanoma http://www.medworm.com/index.php?rid=3213962&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109003387%2Fabstract%3Frss%3Dyes Malignant melanoma is one of the most aggressive cancers. Recently, an increasing number of biomarkers for malignant melanoma like S100, MART-1, and gp100/HMB45 have been identified . We also provided the possibility that Zinc finger protein 28 could be a biomarker for malignant melanoma . These biomarkers are useful for a more detailed diagnostic categorization for malignant melanoma. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3213962 Thu, 28 Jan 2010 14:12:54 +0100 3213962 Food-dependent anaphylaxis with serum IgE immunoreactive to dairy products containing high-molecular-weight proteins http://www.medworm.com/index.php?rid=3213961&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109003375%2Fabstract%3Frss%3Dyes Food-induced anaphylaxis is one of the most common causes of anaphylaxis . Establishing the cause of recurrent anaphylaxis is one of the most important goals of management because identification of the responsible allergens allows avoidance of further exposure. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3213961 Thu, 28 Jan 2010 14:12:54 +0100 3213961 Hair growth promoting effects of adipose tissue-derived stem cells http://www.medworm.com/index.php?rid=3213960&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109003065%2Fabstract%3Frss%3Dyes Adipose tissue-derived stem cells (ADSCs) can display multi-lineage plasticity and share similar characteristics with bone marrow-derived mesenchymal stem cells . Moreover, ADSCs have various cytokine-secreting properties and beneficial paracrine effects on surrounding cells or tissues . Recently, paracrine function is considered one of the most important therapeutic benefits of therapy using mesenchymal stem cells . (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3213960 Thu, 28 Jan 2010 14:12:53 +0100 3213960 A missense mutation in the P2RY5 gene leading to autosomal recessive woolly hair in a Syrian patient http://www.medworm.com/index.php?rid=3213959&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109003260%2Fabstract%3Frss%3Dyes Woolly hair (WH) belongs to a group of disorders characterized by hair shaft anomalies that presents clinically with tightly curled hair . Patients with woolly hair can be divided into two categories. In the first group, woolly hair occurs in the setting of associated cutaneous and/or systemic anomalies. In the second, woolly hair presents as an isolated feature. The distinction between the two categories is critical because woolly hair can occur in the setting of syndromes that can be lethal at early ages due to cardiac arrythmias. Naxos (OMIM 601214) and Carvajal syndromes (OMIM 605676) are conditions that dermatologists should be aware of when managing the woolly hair and cardiologists consultation is mandatory. These syndromes are clinically characterized by woolly hair, palmoplantar k... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3213959 Thu, 28 Jan 2010 14:12:53 +0100 3213959 Life cycle of human melanocytes is regulated by endothelin-1 and stem cell factor in synergy with cyclic AMP and basic fibroblast growth factor http://www.medworm.com/index.php?rid=3213958&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109003405%2Fabstract%3Frss%3Dyes Conclusion: These results suggest that the life cycle of human melanocytes is regulated by ET-1 and SCF in synergy with cAMP and bFGF. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3213958 Thu, 28 Jan 2010 14:12:52 +0100 3213958 Effects of macelignan isolated from Myristica fragrans Houtt. on UVB-induced matrix metalloproteinase-9 and cyclooxygenase-2 in HaCaT cells http://www.medworm.com/index.php?rid=3213957&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002989%2Fabstract%3Frss%3Dyes Conclusion: These results suggest that macelignan protects skin keratinocytes from UVB-induced damage and inhibits MMP-9 and COX-2 expression by attenuating the activation of MAPKs and PI3K/Akt. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3213957 Thu, 28 Jan 2010 14:12:52 +0100 3213957 Glycolic acid induces keratinocyte proliferation in a skin equivalent model via TRPV1 activation http://www.medworm.com/index.php?rid=3213956&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109003612%2Fabstract%3Frss%3Dyes Conclusion: These results suggest that one of the mechanisms of GA-induced epidermal proliferation is a growth response of basal keratinocytes to the local elevation of H+-ion concentration by infiltrated GA. This response is mediated by TRPV1 activation and ATP release. Activation of P2 receptors by the released ATP may also be involved. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3213956 Thu, 28 Jan 2010 14:12:52 +0100 3213956 Epidermal triglyceride levels are correlated with severity of ichthyosis in Dorfman–Chanarin syndrome http://www.medworm.com/index.php?rid=3213955&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109003351%2Fabstract%3Frss%3Dyes Conclusion: These results suggest that TG accumulation by epidermal keratinocytes directly contributes to ichthyosiform phenotype of DCS. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3213955 Thu, 28 Jan 2010 14:12:52 +0100 3213955 Up-regulation of serpin SCCA1 is associated with epidermal barrier disruption http://www.medworm.com/index.php?rid=3213954&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002862%2Fabstract%3Frss%3Dyes Conclusion: All of our findings indicate that SCCA1 plays an important role in the induction of epidermal barrier disruption. SCCA1 may be a critical determinant of barrier function in the epidermis. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3213954 Thu, 28 Jan 2010 14:12:52 +0100 3213954 Novel and recurrent mutations in Keratin 5 and 14 in Korean patients with Epidermolysis bullosa simplex http://www.medworm.com/index.php?rid=3213953&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109003600%2Fabstract%3Frss%3Dyes Conclusions: This study should provide useful data and enhance our understanding of the EBS genotype–phenotype relationship. The genotype–phenotype correlation in Korean EBS patients was similar to previous studies performed in other ethnic groups. Lastly, our results confirmed that the mutational location in KRT5 or KRT14 is the most important factor in determining the phenotype severity. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3213953 Thu, 28 Jan 2010 14:12:48 +0100 3213953 Targeting to the hair follicles: Current status and potential http://www.medworm.com/index.php?rid=3213952&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109003673%2Fabstract%3Frss%3Dyes This article reviews relevant aspects of effective follicle-targeting formulations and delivery systems as well as the activity status of hair follicles, and variations in follicle size and distribution throughout various body regions. Each of these factors strongly affects follicular permeation. We provide examples of improved penetration of particle-based formulations and of a size-dependent manner of follicular penetration. Contradictions are also discussed, indicating the need for detailed future investigations. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3213952 Thu, 28 Jan 2010 14:12:48 +0100 3213952 Medical application of herpes simplex virus http://www.medworm.com/index.php?rid=3213951&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109003077%2Fabstract%3Frss%3Dyes Abstract: Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are important human pathogens that cause a variety of diseases from mild skin diseases such as herpes labialis and herpes genitalis to life-threatening diseases such as herpes encephalitis and neonatal herpes. A number of studies have elucidated the roles of this virus in viral replication and pathogenicity, the regulation of gene expression, interaction with the host cell and immune evasion from the host system. This research has allowed the development of potential therapeutic agents and vectors for human diseases. This review focuses on the basic functions and roles of HSV gene products and reviews the current knowledge of medical applications of genetically engineered HSV mutants using different strategies. These major HS... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3213951 Thu, 28 Jan 2010 14:12:48 +0100 3213951 Editorial Board http://www.medworm.com/index.php?rid=3213950&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181110000071%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3213950 Thu, 28 Jan 2010 14:12:48 +0100 3213950 Announcements http://www.medworm.com/index.php?rid=3116569&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS092318110900348X%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3116569 Thu, 24 Dec 2009 14:00:26 +0100 3116569 Further association analysis of chr 6q22-24 suggests a role of IL-20RA polymorphisms in psoriasis http://www.medworm.com/index.php?rid=3116568&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109003004%2Fabstract%3Frss%3Dyes In our previous studies we obtained evidence that the interleukin-19 (IL19) gene cluster and interleukin-20 receptor alpha (IL20RA) gene may represent susceptibility regions for psoriasis . The aim of the present study was to scan an additional set of single nucleotide polymorphisms (SNPs) in the chromosomal region 6q22-24, which contains IL20RA, the genes for interleukin-22 receptor alpha 2 (IL22RA2) and interferon-gamma receptor 1 (IFNGR1) for association with psoriasis. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3116568 Thu, 24 Dec 2009 14:00:26 +0100 3116568 Novel keratin 14 hotspot mutation in Dowling-Meara type of epidermolysis bullosa simplex: Strategy to avoid KRT14 pseudogene amplification by a simple approach http://www.medworm.com/index.php?rid=3116567&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002886%2Fabstract%3Frss%3Dyes We present a 14-year-old boy, who was referred to our Dermatology Department 8 years ago presenting disseminated hemorrhagic blisters in herpetiform arrangement localized on the thorax, extremities and face. The general blister formation started at birth and progressed during the neonatal period. Skin symptoms were very severe. No family members were affected. With time the symptoms improved. At the age of 13, the patient presented with palmoplantar hyperkeratosis and nail hypertrophy plus occasional blistering. The diagnosis of epidermolysis bullosa simplex Dowling-Meara (EBS, DM) was established on the basis of clinical symptoms and immunofluorescence mapping (IFM) study, in which the skin specimen is labeled with a series of antibodies to determine their binding sites and thus precisely... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3116567 Thu, 24 Dec 2009 14:00:25 +0100 3116567 In vivo characterization of the structure and components of lesional psoriatic skin from the observation with Raman spectroscopy and optical coherence tomography: A pilot study http://www.medworm.com/index.php?rid=3116566&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002990%2Fabstract%3Frss%3Dyes Psoriasis is a chronic, immuno-inflammatory disorder characterised by acanthosis with disturbed keratinocyte differentiation. The stratum corneum (SC) in psoriatic lesional skin is thick and histopathologically composed of parakeratotic cells. A changed lipid pattern of the SC has been observed in lesional skin . However, ceramide profiles in clinically normal psoriatic skin were comparable to those of healthy skin . As the clinical diagnosis of psoriasis is simple, most dermatologists tend to rely on the traditional visual subjective assessments . However, such assessments may still lack objectivity. Recently, commercially available instruments have been used for the objective assessment of psoriasis. Poor hydration state and barrier function in the involved areas were reported . Differen... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3116566 Thu, 24 Dec 2009 14:00:25 +0100 3116566 Construction and immune response of HSV–2gD–Hsp70 DNA vaccine http://www.medworm.com/index.php?rid=3116565&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109003053%2Fabstract%3Frss%3Dyes Herpes simplex virus 2 (HSV-2) infections are common throughout the world. HSV-2 is the most common pathogen of genital herpes. As there are no curative therapies which can effectively control the recurrence of HSV infection, development of an effective and safe vaccine against HSV has become a hot point of research . It has been demonstrated that gD can induce significant cellular and humoral immune responses resulting in the protection of animals from lethal HSV infection . However, none was therapeutically effective and most were poorly immunogenic in human clinical trials . The general failure of prior vaccines suggests the need to test other viral vaccine, particularly those capable of eliciting CD8+ T cell responses. A successful therapeutic vaccine may require different antigens and... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3116565 Thu, 24 Dec 2009 14:00:25 +0100 3116565 The vascular endothelial growth factor +405 G/C polymorphism in psoriasis http://www.medworm.com/index.php?rid=3116564&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109003028%2Fabstract%3Frss%3Dyes Psoriasis is a chronic inflammatory disorder of the skin keratinocytes, involving the expansion and dilation of superficial dermal microvasculature. Both genetic and environmental factors have important roles in the development of the disease. Angiogenesis has been indicated as a common and important pathogenic component in psoriasis, and VEGF, being a key contributor to angiogenesis, was further considered. Several studies have demonstrated that VEGF expression levels were increased in the sera of psoriasis patients , and that VEGF serum levels were directly correlated with disease activity . Keratin14-VEGF (VEGF driven by K14 gene promoter) transgenic mice developed inflammatory skin lesion with many cellular and molecular features mimic psoriasis . (Source: Journal of Dermatological Sci... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3116564 Thu, 24 Dec 2009 14:00:25 +0100 3116564 The H syndrome: Two novel mutations affecting the same amino acid residue of hENT3 http://www.medworm.com/index.php?rid=3116563&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS092318110900293X%2Fabstract%3Frss%3Dyes H syndrome (OMIM 612391) is a recently described autosomal-recessive genodermatosis with systemic manifestations. The disease is characterized by the major clinical findings of progressive cutaneous hyperpigmentation and hypertrichosis located mainly over the lower limbs and lower abdomen, hepatosplenomegaly, heart anomalies, hearing loss, hypogonadism, low height and hyperglycemia/diabetes mellitus . The major histopathological findings include dermal infiltrate consisting mainly of histiocytes, later replaced by dermal and subcutaneous fibrosis . Recently, we and others found that missense, nonsense, compound and deletion mutations in the SLC29A3 gene are responsible for this unique clinical picture. The SLC29A3 gene encodes the human equilibrative nucleoside transporter (hENT3), which m... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3116563 Thu, 24 Dec 2009 14:00:25 +0100 3116563 Sphingosylphosphorylcholine induces degranulation of mast cells in the skin and plasma exudation in the ears of mice http://www.medworm.com/index.php?rid=3116562&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002898%2Fabstract%3Frss%3Dyes Pruritus is one of cardinal symptoms of atopic dermatitis, the control of itching is important in its treatment. Its molecular mechanisms remain largely unexplained. Certainly, an itch–scratch vicious cycle, in which scratch irritation enhances itch, is at work in atopic patients . A defective epidermal barrier due to a marked decrease of ceramide in atopic dermatitis allows the penetration of allegens through the skin, facilitating the interaction of these allergens with the local antigen-presenting cells and immune-effector cells . Disturbed skin-barrier function in atopic dermatitis is at least partly related to a disturbed lipid composition of the stratum corneum. A significant reduction in ceramides has been found in lesional as well as non-lesional skin of atopic dermatitis patient... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3116562 Thu, 24 Dec 2009 14:00:24 +0100 3116562 Polymorphisms in the FOXP3 gene in Han Chinese psoriasis patients http://www.medworm.com/index.php?rid=3116561&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002928%2Fabstract%3Frss%3Dyes Conclusions: FOXP3 polymorphisms appear to contribute to the risk of psoriasis in a Han Chinese population. Larger studies are needed to confirm these findings. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3116561 Thu, 24 Dec 2009 14:00:24 +0100 3116561 Collared mice: A model to assess the effects of scratching http://www.medworm.com/index.php?rid=3116560&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002904%2Fabstract%3Frss%3Dyes Conclusions: This model enables the dissection of the various elements assessed when measuring CH in mice and may provide a simple tool to assess or screen potential anti-pruritic agents. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3116560 Thu, 24 Dec 2009 14:00:24 +0100 3116560 Prognosis of 100 Japanese patients with mycosis fungoides and Sézary syndrome http://www.medworm.com/index.php?rid=3116559&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS092318110900303X%2Fabstract%3Frss%3Dyes Conclusion: Patient age and stage are the most important clinical prognostic factors in Japanese patients with MF and SS. The revised staging system is useful for predicting survival of the patients, but at least a subpopulation of stage IIIA patients may have a favorable prognosis. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3116559 Thu, 24 Dec 2009 14:00:24 +0100 3116559 Lichen planopilaris and pseudopelade of Brocq involve distinct disease associated gene expression patterns by microarray http://www.medworm.com/index.php?rid=3116558&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109003041%2Fabstract%3Frss%3Dyes Conclusions: Our findings may have important implications for understanding the pathogenesis of LPP and PPB at the molecular level. Results suggest LPP and PPB involve different mechanisms of disease development and should be regarded as biologically distinct cicatricial alopecia diagnoses. Genes that we have identified may be useful as markers of the respective diagnoses and may be potential therapeutic targets. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3116558 Thu, 24 Dec 2009 14:00:24 +0100 3116558 UV decreases the synthesis of free fatty acids and triglycerides in the epidermis of human skin in vivo, contributing to development of skin photoaging http://www.medworm.com/index.php?rid=3116557&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109003016%2Fabstract%3Frss%3Dyes Conclusion: Our results suggest that TG and FFA may play important roles in photoaging of human skin. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3116557 Thu, 24 Dec 2009 14:00:23 +0100 3116557 Recovery from tanning induced by narrow-band UVB phototherapy in brown-skinned individuals with psoriasis: Twelve-month follow-up http://www.medworm.com/index.php?rid=3116556&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002977%2Fabstract%3Frss%3Dyes Conclusion: Understanding the recovery process from tanning induced by NBUVB treatment will improve the patient's compliance for treatment and bring higher efficacy and safety to the retrial of phototherapy in brown-skinned individuals with psoriasis. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3116556 Thu, 24 Dec 2009 14:00:23 +0100 3116556 Review of hair follicle dermal cells http://www.medworm.com/index.php?rid=3116555&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109003399%2Fabstract%3Frss%3Dyes Abstract: Hair follicle stem cells in the epithelial bulge are responsible for the continual regeneration of the hair follicle during cycling. The bulge cells reside in a niche composed of dermal cells. The dermal compartment of the hair follicle consists of the dermal papilla and dermal sheath. Interactions between hair follicle epithelial and dermal cells are necessary for hair follicle morphogenesis during development and in hair reconstitution assays. Dermal papilla and dermal sheath cells express specific markers and possess distinctive morphology and behavior in culture. These cells can induce hair follicle differentiation in epithelial cells and are required in hair reconstitution assays either in the form of intact tissue, dissociated freshly prepared cells or cultured cells. This ... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3116555 Thu, 24 Dec 2009 14:00:23 +0100 3116555 Changes to JSID—From a closed to an open society http://www.medworm.com/index.php?rid=3116554&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109003272%2Fabstract%3Frss%3Dyes My service as Chief of the Scientific Program Committee for the International Investigative Dermatology (IID) meeting in Kyoto in 2008 and for the Japanese Society for Investigative Dermatology (JSID) meetings in 2007 and 2009 has provided me with a unique perspective, and I would like to say a few words regarding the changes that have occurred in JSID over the last 3 years. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3116554 Thu, 24 Dec 2009 14:00:23 +0100 3116554 Editorial Board http://www.medworm.com/index.php?rid=3116553&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109003430%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3116553 Thu, 24 Dec 2009 14:00:23 +0100 3116553 Announcements http://www.medworm.com/index.php?rid=3016084&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109003156%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3016084 Sun, 22 Nov 2009 14:02:23 +0100 3016084 Erratum to “Oral administration of Yokukansan inhibits the development of atopic dermatitis-like lesions in isolated NC/Nga mice” [J. Dermatol. Sci. 56 (2009) 37–42] http://www.medworm.com/index.php?rid=3016083&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109003284%2Fabstract%3Frss%3Dyes The Author regrets that when this paper was originally published, magnification details in the caption for Figure 1 were incorrect. plus the correct caption are as follows: (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3016083 Sun, 22 Nov 2009 14:02:22 +0100 3016083 JSID Abstracts http://www.medworm.com/index.php?rid=3016082&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002965%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3016082 Sun, 22 Nov 2009 14:02:22 +0100 3016082 Dietary glucosylceramide is absorbed into the lymph and increases levels of epidermal sphingolipids http://www.medworm.com/index.php?rid=3016081&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002746%2Fabstract%3Frss%3Dyes The positive effects of dietary glucosylceramide (GlcCer) are well-known. In previous experiments, the efficacy was demonstrated in increasing skin moisture of human subjects , in repairing disrupted skin barrier functions of mice , and in relieving allergic skin symptoms of atopic patients , but the underlying mechanism is incompletely defined. Our study was performed (1) to confirm whether or not dietary GlcCer increases the epidermal ceramide (Cer) levels and (2) to identify Cer metabolites in thoracic lymph fluid in animal models. All procedures performed in this study were approved by the Ethical Committee of Kao Corporation and conform to the guidelines for the animal experimentation. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3016081 Sun, 22 Nov 2009 14:02:22 +0100 3016081 UVB wavelength dependency of antimicrobial peptide induction for innate immunity in normal human keratinocytes http://www.medworm.com/index.php?rid=3016080&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002357%2Fabstract%3Frss%3Dyes Sunlight, which includes UVB wavelengths from 290 to 320nm, induces inflammatory responses in the skin. During sunburn reactions, autoantigens might be exposed to the acquired immune system, causing an autoimmune reaction. The emergence of a series of immune suppressants, including soluble factors, e.g., IL-10 and RANKL , and other factors, such as the disappearance of antigen-presenting cells (dendritic cells) and the induction of regulatory T cells , contributes to prevent autoimmune reactions. In our previous study, delayed-type hypersensitivity (DTH) responses were suppressed by narrowband (NB)-UVB irradiation . In a mouse model, UVB-induced suppression of DTH was associated with the induction of Foxp3-expressing T cells. UVB-induced suppression of DTH was tested among several waveleng... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3016080 Sun, 22 Nov 2009 14:02:22 +0100 3016080 5-ALA derivative-mediated photoinactivation of Propionibacterium acnes http://www.medworm.com/index.php?rid=3016079&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002291%2Fabstract%3Frss%3Dyes 5-Aminolevulinic acid (5-ALA)-mediated photodynamic therapy (PDT) combines the administration 5-ALA which is selectively converted into the photosensitizer protoporphyrin IX (PpIX) in diseased cells, irradiation with light, and oxygen . The concerted action of these elements produces highly reactive oxygen species which, in turn, destroy cells of high PpIX content. Due to the unfavourable local bioavailability of 5-ALA, more lipophilic derivatives have been proposed, and methyl aminolevulinate (MAL) and hexyl aminolevulinate (HAL) recently gained marketing authorization . MAL is now approved for the treatment of dermatologic conditions including actinic keratosis and difficult-to-treat basal cell carcinoma. Besides its use in dermal oncology, PDT has been employed for the photodynamic inac... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3016079 Sun, 22 Nov 2009 14:02:21 +0100 3016079 Screening of the specific polyoma virus as diagnostic and prognostic tools for Merkel cell carcinoma http://www.medworm.com/index.php?rid=3016078&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002333%2Fabstract%3Frss%3Dyes Merkel cell carcinoma (MCC) is a rare and very aggressive skin cancer of the elderly. It is a primary neuroendocrine carcinoma consisting of malignant small cells typically expressing cytokeratin 20 and neuroendocrine markers. The nationwide investigation into the epidemiology of MCC in Japan presented 174 cases at the year of 1995, so that the estimated prevalence of MCC in Japan was 1.45 per million . It is known that MCC is associated with advanced age and immunosuppressive condition such as patients with renal transplant and AIDS, raising the possibility that MCC may have an infectious origin. Recently, Feng et al. identified a new human polyomavirus, which was named Merkel cell polyomavirus (MCV) and found the virus DNA in 8 of 10 (80%) MCC patients . Subsequent studies have confirmed... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3016078 Sun, 22 Nov 2009 14:02:21 +0100 3016078 The glutathione-S-transferase P1 polymorphisms correlates with changes in expression of TP53 tumor suppressor in cutaneous basal cell carcinoma http://www.medworm.com/index.php?rid=3016077&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS092318110900262X%2Fabstract%3Frss%3Dyes Basal cell carcinoma (BCC), includes about 80% of reported non-melanoma skin cancer . DNA damage induced by free radical production is known to be an inducer of genetic mutation, initiating uncontrolled cell proliferation. Different buffering systems such as glutathione are responsible for decreasing this stress. Glutathione-S-transferase (GST) variants (GSTM, GSTT and GSTP) replenishes reduced form of glutathione in cell . So, it can be concluded that polymorphisms of these enzymes resulting in decreased function might lead to increased DNA and protein damage. Moreover, GSTM1 A/B heterozygote genotype has been reported to be protective against multiple BCC and GST T1 null mutation is associated with clusters of BCC compared to single BCC's . (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3016077 Sun, 22 Nov 2009 14:02:21 +0100 3016077 Mutations in the LIPH gene in three Japanese families with autosomal recessive woolly hair/hypotrichosis http://www.medworm.com/index.php?rid=3016076&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002606%2Fabstract%3Frss%3Dyes In this study, we identified novel pathogenic mutations in the LIPH gene in three Japanese families with ARWH/H. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3016076 Sun, 22 Nov 2009 14:02:21 +0100 3016076 Lonicera caerulea and Vaccinium myrtillus fruit polyphenols protect HaCaT keratinocytes against UVB-induced phototoxic stress and DNA damage http://www.medworm.com/index.php?rid=3016075&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002588%2Fabstract%3Frss%3Dyes Conclusion: The results suggest that the phenolic fraction of L. caerulea and V. myrtillus fruits suppress UVB-caused injury to keratinocytes. These results now need to be demonstrated in vivo. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3016075 Sun, 22 Nov 2009 14:02:20 +0100 3016075 Living skin equivalents constructed using human amnions as a matrix http://www.medworm.com/index.php?rid=3016074&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002916%2Fabstract%3Frss%3Dyes Conclusion: A LSE with amnions as a matrix exhibited good morphology, low cost, and good mechanical properties and may be useful as a skin substitute for clinical use. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3016074 Sun, 22 Nov 2009 14:02:20 +0100 3016074 Isolation of small-sized human epidermal progenitor/stem cells by Gravity Assisted Cell Sorting (GACS) http://www.medworm.com/index.php?rid=3016073&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002837%2Fabstract%3Frss%3Dyes Conclusion: These results indicate that GACS is simple and useful technique to enrich for epidermal progenitor/stem cell populations, and is more efficient when used on cells in culture. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3016073 Sun, 22 Nov 2009 14:02:20 +0100 3016073 Scarless healing of oral mucosa is characterized by faster resolution of inflammation and control of myofibroblast action compared to skin wounds in the red Duroc pig model http://www.medworm.com/index.php?rid=3016072&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002874%2Fabstract%3Frss%3Dyes Conclusions: Earlier resolution of the inflammatory reaction and reduced wound contraction may promote scarless oral mucosal wound healing. In addition, scar formation likely depends not only on the number of myofibroblasts but also on the extracellular environment which regulates their function. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3016072 Sun, 22 Nov 2009 14:02:20 +0100 3016072 Psoriasis patients generate increased serum levels of autoantibodies to tumor necrosis factor-α and interferon-α http://www.medworm.com/index.php?rid=3016071&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002618%2Fabstract%3Frss%3Dyes Conclusions: Psoriasis patients produce markedly increased levels of auto Abs to TNF-α and IFN-α which are two of the key cytokines in this disorder. The presence of these auto Abs which possess some neutralizing activity in vitro, may be an epiphenomenon or might play a role in attempting to suppress the ongoing inflammatory process. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3016071 Sun, 22 Nov 2009 14:02:20 +0100 3016071 Telomeric DNA induces p53-dependent reactive oxygen species and protects against oxidative damage http://www.medworm.com/index.php?rid=3016070&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS092318110900259X%2Fabstract%3Frss%3Dyes Conclusion: These results suggest the existence of innate telomere-based protective responses that act to reduce oxidative damage to cells. T-oligo treatment induces the same responses and offers a new model for studying intracellular ROS signaling and the relationships between DNA damage, ROS, oxidative stress, and cellular defense mechanisms. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3016070 Sun, 22 Nov 2009 14:02:19 +0100 3016070 EGFR ligands and their signaling scissors, ADAMs, as new molecular targets for anticancer treatments http://www.medworm.com/index.php?rid=3016069&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002953%2Fabstract%3Frss%3Dyes Abstract: Members of the human epidermal growth factor receptor (HER) family of receptor tyrosine kinases and their ligands (EGFR ligands) are known to play crucial roles in the regulation of cell proliferation and differentiation, and in the survival of many types of cancer. HER family members are activated in cancer cells and are now considered to be useful molecular targets for cancer therapy. Recently, several new drugs, including monoclonal antibodies and small-molecule inhibitors that target HER members, have been developed and clinically used to treat solid tumors. Members of a disintegrin and metalloproteinase (ADAM) family are thought to mediate the shedding of EGFR ligands and this event is critical for the production of soluble functional EGFR ligands. In melanoma cells, UV irra... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3016069 Sun, 22 Nov 2009 14:02:19 +0100 3016069 L-selectin: Role in regulating homeostasis and cutaneous inflammation http://www.medworm.com/index.php?rid=3016068&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002941%2Fabstract%3Frss%3Dyes Abstract: The maintenance of immune surveillance and the generation of normal immune responses are dependent on leukocyte migration to appropriate lymphoid and non-lymphoid tissues. The process of leukocyte migration occurs through complex and highly regulated interactions between the circulating leukocytes and the vascular endothelium. Multiple families of adhesion molecules as well as specific chemoattractants and their cognate receptors function to stabilize these interactions and induce migration into the tissue. L-selectin is a key adhesion molecule that regulates both the migration of leukocytes at sites of inflammation and the recirculation of lymphocytes between blood and lymphoid tissues. L-selectin-mediated lymphocyte recirculation is required for maintaining the appropriate tiss... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3016068 Sun, 22 Nov 2009 14:02:19 +0100 3016068 Editorial Board http://www.medworm.com/index.php?rid=3016067&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109003107%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=3016067 Sun, 22 Nov 2009 14:02:19 +0100 3016067 Announcements http://www.medworm.com/index.php?rid=2860187&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002710%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2860187 Mon, 05 Oct 2009 16:28:47 +0100 2860187 Olopatadine hydrochloride inhibits scratching behavior induced by a proteinase-activated receptor 2 agonist in mice http://www.medworm.com/index.php?rid=2860186&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002205%2Fabstract%3Frss%3Dyes Proteinase-activated receptors (PARs), a group of G protein-coupled receptors, are activated by the cleavage of their N-terminal domain by serine proteinases . The proteolytic cleavage of the N-terminal region of PARs unmasks a new N-terminal sequence that acts as a tethered ligand that binds and activates the receptor itself . The PAR2 subtype is highly expressed in the skin, is activated by trypsin and mast cell tryptase, and can be activated without the need for proteolysis by synthetic PAR2 agonists, such as SLIGRL-NH2 . Tryptase and PAR2 are up-regulated on sensory nerves in the skin from atopic dermatitis patients . Indeed, intradermal injections of SLIGRL-NH2 evoke dose-dependent scratching in mice . In addition, PAR2 agonists induce the release of neuropeptide, such as substance P,... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2860186 Mon, 05 Oct 2009 16:28:47 +0100 2860186 Expression of hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha with progression of keratinocytic neoplasms http://www.medworm.com/index.php?rid=2860185&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002035%2Fabstract%3Frss%3Dyes Low oxygen levels are frequently encountered in solid tumors, and tumor growth, angiogenesis, invasion and metastasis are regulated by hypoxia-stimulated genes, such as hypoxia-inducible factors (HIFs) . Under low oxygen concentration, HIF-1alpha and HIF-2alpha translocate to the nucleus, heterodimerize with HIF-1beta, and activate target genes. High expression of HIFs has been correlated with frequent mutations of tumor suppressor genes such as p53 and PTEN, enhanced cellular proliferation, and decreased apoptosis . C-myc controls the G1-S cell-cycle transition and is overexpressed in many human tumors. HIF-1alpha is known to disrupt c-myc, and causes transcriptional repression of some c-myc target genes. Conversely, HIF-2alpha increases c-myc transcriptional activity at specific genes . ... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2860185 Mon, 05 Oct 2009 16:28:47 +0100 2860185 Morphological relationship between nerve fibers and Langerhans cells in the epidermis of psoriasis vulgaris and lichen simplex chronicus http://www.medworm.com/index.php?rid=2860184&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002308%2Fabstract%3Frss%3Dyes It is generally accepted that skin is a target organ of the stress reaction . There is a close correlation between psoriasis vulgaris (PV), lichen simplex chronicus (LSC) and certain psychoneural factors. Both PV and LSC are associated with psychologic disorders and can be aggravated by anxiety or depression. Quantitative analysis of nerve fibers in the lesions of PV provides morphological evidence for the functional role of nervous system in PV . However, quantitative analysis of nerve fibers in the lesions of LSC and morphological relationship between nerve fibers and LCs in the lesions of PV and LSC have not been reported. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2860184 Mon, 05 Oct 2009 16:28:46 +0100 2860184 The first case report of a Chinese Hermansky–Pudlak syndrome patient with a novel mutation on HPS1 gene http://www.medworm.com/index.php?rid=2860183&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002217%2Fabstract%3Frss%3Dyes Hermansky–Pudlak syndrome (HPS; OMIM 203300) is an autosomal recessive and a genetically heterogeneous disorder characterized by oculocutaneous albinism (OCA), bleeding tendency, and ceroid deposition which may cause lung fibrosis, colitis, and cardiomyopathy. Patients with HPS often die in their middle ages . The hallmark of pathological features of HPS is the disrupted biogenesis of lysosome-related organelles (LROs), such as melanosomes and platelet dense granules . The identification of the first HPS gene, HPS1, in 1996 prompts the identification of seven other HPS genes (HPS2–HPS8) during the past decade . (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2860183 Mon, 05 Oct 2009 16:28:46 +0100 2860183 Endogenous expression of TRPV1 channel in cultured human melanocytes http://www.medworm.com/index.php?rid=2860182&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS092318110900200X%2Fabstract%3Frss%3Dyes The vanilloid receptor 1 (transient receptor potential vanilloid type 1, TRPV1) is a non-selective cation channel that binds vanilloids and was originally described to be activated by the naturally occurring lipophilic alkaloid capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide), a substance not synthesized in the human body . Recently, endogenous ligands including anandamide (arachidonylethanolamine) and lipoxygenases by-products such as 12-hydroperoxyeicosatetraenoic acid, N-arachidonyldopamine, and N-oleoyldopamine were also described to activate TRPV1 . Therefore, TRPV1 was suggested as a key integrator molecule of various nociceptive stimuli. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2860182 Mon, 05 Oct 2009 16:28:46 +0100 2860182 Histamine induces human β-defensin-3 production in human keratinocytes http://www.medworm.com/index.php?rid=2860181&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002345%2Fabstract%3Frss%3Dyes Conclusion: It is suggested that histamine induces hBD-3 production in human keratinocytes through H1 receptors by activating STAT3 and AP-1 via JAK2 and MEK/ERK. Histamine may promote cutaneous antimicrobial defense, inflammation, and wound repair through hBD-3. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2860181 Mon, 05 Oct 2009 16:28:46 +0100 2860181 Cultured human melanocytes express functional Toll-like receptors 2–4, 7 and 9 http://www.medworm.com/index.php?rid=2860180&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002576%2Fabstract%3Frss%3Dyes Conclusion: Present study indicates human melanocytes express a panel of functional TLRs. The ligation of TLRs can turn these cells into active players of the skin innate immunity. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2860180 Mon, 05 Oct 2009 16:28:46 +0100 2860180 Nicotinamide inhibits Propionibacterium acnes-induced IL-8 production in keratinocytes through the NF-κB and MAPK pathways http://www.medworm.com/index.php?rid=2860179&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002369%2Fabstract%3Frss%3Dyes Conclusion: Our results indicate that nicotinamide inhibits IL-8 production through the NF-κB and MAPK pathways in an in vitro keratinocytes/P. acnes model of inflammation. Keratinocytes involved in the innate immune response may be a suitable target for treatment during the early phase of inflammation. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2860179 Mon, 05 Oct 2009 16:28:46 +0100 2860179 Eczema, respiratory allergies, and traffic-related air pollution in birth cohorts from small-town areas http://www.medworm.com/index.php?rid=2860178&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002321%2Fabstract%3Frss%3Dyes Abstract: Background: Traffic-related air pollution (TAP) impairs respiratory health and could influence the development of allergies, as was demonstrated in urban areas with relatively high pollution. Whether eczema is affected by TAP was rarely investigated.Objective: To investigate whether exposure to TAP affects eczema and respiratory allergies also in small-town areas with lower concentrations of pollution.Methods: Between 1995 and 1999, we recruited 3390 newborns from small-town areas. Diagnoses and symptoms of eczema and respiratory allergies were recorded by annual questionnaires. Seventy-seven percent of families participated until the child's 6th birthday, when a clinical test for eczema and IgE-sensitization was performed. Individual exposure to traffic-related soot and NO2 at t... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2860178 Mon, 05 Oct 2009 16:28:45 +0100 2860178 Effectiveness of different substrate materials for in vitro sunscreen tests http://www.medworm.com/index.php?rid=2860177&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS092318110900231X%2Fabstract%3Frss%3Dyes In this study, several substrates have been fully characterized for in vitro sunscreen testing.Methods: The following different substrates have been utilised in the study: roughened PMMA plates, Transpore, Vitro-Skin, roughened quartz plate and a laboratory prepared roughened PTFE plate. The suitability of these substrates for SPF evaluation has been investigated by performing total absorbance measurements of seven sunscreen products with different SPF values produced by the same manufacturer.Results and conclusions: Application of sunscreen products on Transpore, roughened quartz plate, PMMA, PTFE and Vitro-Skin was performed efficiently. With regard to photo-stability of the substrate materials, only PMMA plate, PTFE and roughened quartz plate showed to be photo-stable after UV irradiati... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2860177 Mon, 05 Oct 2009 16:28:45 +0100 2860177 Rapamycin selectively inhibits expression of an inducible keratin (K6a) in human keratinocytes and improves symptoms in pachyonychia congenita patients http://www.medworm.com/index.php?rid=2860176&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS092318110900228X%2Fabstract%3Frss%3Dyes Conclusion: Rapamycin selectively blocks K6a expression in human keratinocytes. The improvement of symptoms in PC patients following rapamycin treatment suggests rapamycin (or rapamycin analogs) may be a therapeutic option, particularly if topical formulations can be developed that avoid the side effects associated with systemic administration. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2860176 Mon, 05 Oct 2009 16:28:45 +0100 2860176 DNA damage responses in skin biology—Implications in tumor prevention and aging acceleration http://www.medworm.com/index.php?rid=2860175&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002631%2Fabstract%3Frss%3Dyes Abstract: UV irradiation is the main etiological cause of most types of skin cancers and can accelerate skin photoaging. UV irradiation results in several types of DNA damage in eukaryotic cells, such as DNA single strand breaks, DNA interstrand cross-links, and nucleotide base modifications. In response to such DNA damages, mammalian cells exert DNA damage responses including cell cycle checkpoints, well-developed DNA repair, apoptosis and premature senescence to prevent genomic instability. Cell cycle checkpoints are important surveillance systems to maintain genomic integrity. Once checkpoint systems sense the abnormal chromosomal DNA structures, they execute cell cycle arrest through inhibiting the activity of cell cycle regulators and coordinate it with the DNA repair process. Checkpo... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2860175 Mon, 05 Oct 2009 16:28:45 +0100 2860175 The international role of the Japanese Society for Investigative Dermatology (JSID): Secretary General's Perspective http://www.medworm.com/index.php?rid=2860174&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002370%2Fabstract%3Frss%3Dyes After serving as the Editor-in-Chief of the Journal of Dermatological Science (JDS) for the past 5 years, I assumed the five-year Secretary Generalship of the JSID in 2008. With Prof. Yoshiki Tokura as the new president and Prof. Akimichi Morita as the new JDS Editor-in-Chief, I believe it is an appropriate time to consider the JSID's future. Together with increases in the quality and impact factor of the JDS, the JSID's international role on skin science has become clearer (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2860174 Mon, 05 Oct 2009 16:28:44 +0100 2860174 Editorial Board http://www.medworm.com/index.php?rid=2860173&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002667%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2860173 Mon, 05 Oct 2009 16:28:44 +0100 2860173 Announcements http://www.medworm.com/index.php?rid=2746432&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS092318110900245X%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2746432 Mon, 31 Aug 2009 11:59:26 +0100 2746432 No involvement of the NOD1 polymorphism Glu266Lys in Japanese leprosy patients http://www.medworm.com/index.php?rid=2746431&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002023%2Fabstract%3Frss%3Dyes Leprosy (Hansen's disease) is a chronic infectious disease caused by Mycobacterium leprae (M. leprae) and primarily affects the skin and the peripheral nervous system. In Japan, occurrence of new patients is quite rare and most patients are already very old to live in or close to the leprosaria, although more than 200,000 patients newly arise per year in the whole world . Leprosy shows apparent phenotypic heterogeneity depending on the host's immunological response to the pathogen. One is the tuberculoid (T-) type, characterized by formation of epithelioid cell granuloma without apparent bacilli due to the host's strong cell-mediated immunity, and the other is the lepromatous (L-) type, characterized by lipoid degeneration accompanied with multiple bacilli due to the host's defective cell-... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2746431 Mon, 31 Aug 2009 11:59:26 +0100 2746431 Significance of cyclin D1-, product of retinoblastoma (pRb), p53, p63 and p73 expression in eccrine poroma and eccrine porocarcinoma http://www.medworm.com/index.php?rid=2746430&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS092318110900190X%2Fabstract%3Frss%3Dyes Eccrine porocarcinoma (EPC) is a rare malignant tumor arising from the intraepidermal portion of the eccrine sweat gland duct epithelium or from pre-existing eccrine poroma (EP) , and the precise pathogenesis remains unclear. We have previously reported that activating transcription factor-2- and signal transducer and activator of transcription-3 signaling pathways might contribute to the formation of both EP and EPC , but neither factor was able to dissect EPC from EP. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2746430 Mon, 31 Aug 2009 11:59:26 +0100 2746430 The compound heterozygote for new/recurrent COL7A1 mutations in a Japanese patient with bullous dermolysis of the newborn http://www.medworm.com/index.php?rid=2746429&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001947%2Fabstract%3Frss%3Dyes In this study, we investigated COL7A1 gene pathology in an additional Japanese patient with BDN and identified compound heterozygous new/recurrent mutations. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2746429 Mon, 31 Aug 2009 11:59:25 +0100 2746429 Anti-inflammatory and barrier protecting effect of Lithospermum erythrorhizon extracts in chronic oxazolone-induced murine atopic dermatitis http://www.medworm.com/index.php?rid=2746428&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002011%2Fabstract%3Frss%3Dyes Atopic dermatitis (AD) is a chronic inflammatory, and highly pruritic skin disease of which prevalence is steadily increasing along with industrialization . Corticosteroids are generally prescribed to control the symptoms of AD, yet the repeated use can cause severe skin atrophy, susceptibility to infection and adrenal suppression etc. Due to these profound side effects, chronic usages have been actively avoided, even arousing a strong antipathy against corticosteroid, so called “steroid phobia” . In this background, many attempts have been made to develop alternative therapies and in particular, much attention has been given into the development of herbal medicine or dietary supplement for its merit in safety and nature-friendly images. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2746428 Mon, 31 Aug 2009 11:59:25 +0100 2746428 Recurrent European missense mutation in the F12 gene in a British family with type III hereditary angioedema http://www.medworm.com/index.php?rid=2746427&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001923%2Fabstract%3Frss%3Dyes Hereditary angioedema (HAE; OMIM 106100) is an autosomal dominant condition that is genetically heterogeneous (). The classic forms, types I and II HAE, both result from mutations in the gene encoding the C1 inhibitor (SERPING1) . A third type of inherited HAE has been described recently. Affected individuals have recurrent angioedema without wheals and have normal C1 inhibitor function . This new type of HAE (designated type III HAE) almost exclusively affects females, and appears to be associated with high estrogen levels (hence the previous name of estrogen-related HAE) . In 2006, Dewald and Bork identified the F12 gene, encoding coagulation factor XII (F12, Hageman-factor) as the type III HAE gene, and reported two pathogenic heterozygous missense mutations, p.Thr328Lys and p.Thr328Arg... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2746427 Mon, 31 Aug 2009 11:59:25 +0100 2746427 Expression of selected ADAMs in bullous pemphigoid and dermatitis herpetiformis http://www.medworm.com/index.php?rid=2746426&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001911%2Fabstract%3Frss%3Dyes Dermatitis herpetiformis (DH) and bullous pemphigoid (BP) are autoimmune diseases characterized by destruction of the basement membrane zone and anchoring fibers. Recent studies established biochemical properties of a disintegrin and metalloproteinase (ADAMs) and their high affinity to the basement membrane components, especially collagen type XVII and VII . Moreover, ADAMs are responsible for shedding of several proteins from the cells surface, for example TNFα . There is still no evidence on the expression and the possible function of ADAMs in blister formation. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2746426 Mon, 31 Aug 2009 11:59:25 +0100 2746426 In vitro impact of a whey protein isolate (WPI) and collagen hydrolysates (CHs) on B16F10 melanoma cells proliferation http://www.medworm.com/index.php?rid=2746425&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001881%2Fabstract%3Frss%3Dyes Conclusion: It is suggested that a mechanism for tumorigenesis inhibition may involve the caspases cascade and apoptosis. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2746425 Mon, 31 Aug 2009 11:59:25 +0100 2746425 Differential down-regulation of COX-2 and MMP-13 in human skin fibroblasts by glucosamine-hydrochloride http://www.medworm.com/index.php?rid=2746424&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001984%2Fabstract%3Frss%3Dyes Conclusions: GS–HCl differentially down-regulates COX-2 and MMP-13 expression in the IL-1β- or PMA-treated human skin fibroblasts via the p38 MAPK-independent COX-2 translational inhibition and the p38 MAPK-dependent MMP-13 transcriptional suppression, respectively. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2746424 Mon, 31 Aug 2009 11:59:24 +0100 2746424 Oral administration of Yokukansan inhibits the development of atopic dermatitis-like lesions in isolated NC/Nga mice http://www.medworm.com/index.php?rid=2746423&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001996%2Fabstract%3Frss%3Dyes Conclusion: YKS inhibited the development of AD-like skin lesions in socially isolated NC/Nga mice by suppressing scratching and infiltration of inflammatory cells in the skin. These results indicate that YKS possesses an anti-itching property, and its anti-itching may be partly through attenuation on social isolation stress. It is expected that YKS might provide an effective alternative therapy for AD in human patients. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2746423 Mon, 31 Aug 2009 11:59:24 +0100 2746423 DNA demethylation of the perforin promoter in CD4+ T cells from patients with subacute cutaneous lupus erythematosus http://www.medworm.com/index.php?rid=2746422&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001959%2Fabstract%3Frss%3Dyes Conclusions: DNA demethylation at the perforin locus contributes to perforin overexpression in SCLE CD4+ T cells. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2746422 Mon, 31 Aug 2009 11:59:24 +0100 2746422 Mutations in the SLURP-1 gene underlie Mal de Meleda in three Pakistani families http://www.medworm.com/index.php?rid=2746421&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001935%2Fabstract%3Frss%3Dyes Conclusion: Our results expand the spectrum of mutations in SLURP-1 gene. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2746421 Mon, 31 Aug 2009 11:59:24 +0100 2746421 Cutaneous wound reepithelialization is compromised in mice lacking functional Slug (Snai2) http://www.medworm.com/index.php?rid=2746420&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001960%2Fabstract%3Frss%3Dyes Conclusion: Slug is an important modulator of successful wound repair in adult tissue and may be critical for maintaining epidermal integrity in response to chronic injury. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2746420 Mon, 31 Aug 2009 11:59:24 +0100 2746420 Long-term follow-up of patients with recessive dystrophic epidermolysis bullosa in the Netherlands: Expansion of the mutation database and unusual phenotype–genotype correlations http://www.medworm.com/index.php?rid=2746419&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001893%2Fabstract%3Frss%3Dyes Conclusion: Pseudosyndactyly occurs in approximately half of RDEB-O patients when type VII collagen is strongly reduced. The prognosis in RDEB cannot always be simply predicted from the COL7A1 genotype. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2746419 Mon, 31 Aug 2009 11:59:23 +0100 2746419 Multiphoton microscopy in dermatological imaging http://www.medworm.com/index.php?rid=2746418&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001972%2Fabstract%3Frss%3Dyes Abstract: A minimally invasive imaging modality that provides both cellular and extracellular structural information with subcellular resolution is helpful for clinical diagnosis as well as basic laboratory research in dermatology. Multiphoton microscopy (MPM), using femtosecond laser as the light source, is efficient in non-linear excitation of endogenous fluorophores and induction of second harmonic generation signals from non-centrosymmetric biomolecules such as collagen. This imaging modality is minimally invasive in the sense that much of the traditional histological procedures can be bypassed en route to obtain morphological and structural information of high scattering skin tissues. This unique feature has allowed clinical dermatological diagnosis, both ex vivo and in vivo. In addit... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2746418 Mon, 31 Aug 2009 11:59:23 +0100 2746418 The latest impact factor for Journal of Dermatological Science is now 2.97! http://www.medworm.com/index.php?rid=2746417&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002540%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2746417 Mon, 31 Aug 2009 11:59:23 +0100 2746417 Editorial Board http://www.medworm.com/index.php?rid=2746416&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002400%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2746416 Mon, 31 Aug 2009 11:59:23 +0100 2746416 Announcements http://www.medworm.com/index.php?rid=2642633&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002114%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2642633 Tue, 28 Jul 2009 10:52:24 +0100 2642633 Circulating levels of adiponectin, oxidized LDL and C-reactive protein in Portuguese patients with psoriasis vulgaris, according to body mass index, severity and duration of the disease http://www.medworm.com/index.php?rid=2642632&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001625%2Fabstract%3Frss%3Dyes Psoriasis vulgaris, a chronic inflammatory disease, associates with oxidative stress, dislipidaemia, overweight/obesity, low adiponectin levels and a high frequency in cardiovascular diseases (CVD) . However, there are no reports studying the relation of CVD risk factors with body mass index (BMI), severity and duration of psoriasis. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2642632 Tue, 28 Jul 2009 10:52:24 +0100 2642632 SMAD3 as an atopic dermatitis susceptibility gene in the Japanese population http://www.medworm.com/index.php?rid=2642631&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS092318110900187X%2Fabstract%3Frss%3Dyes Atopic dermatitis (AD) is a hereditary, pruritic, inflammatory, and chronic skin disease that occurs most commonly in early childhood but can persist in or even begin in adulthood. AD is a common disease of complex inheritance, and twin and family studies have confirmed the existence of a genetic predisposition to the development of AD, with a heritability of 0.72 , although a clear Mendelian pattern of inheritance has not been established. Recent studies have emphasized the importance of skin barrier function in the development of AD. Loss-of-function mutations of the filaggrin gene (FLG) were found to be associated with AD in various ethnic populations . In addition to FLG, other factors such as epidermal growth factor, transforming growth factor (TGF)-β, and fibroblast growth factor ar... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2642631 Tue, 28 Jul 2009 10:52:23 +0100 2642631 Abnormal collagen deposition in fibromas from patient with juvenile hyaline fibromatosis http://www.medworm.com/index.php?rid=2642630&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001662%2Fabstract%3Frss%3Dyes Juvenile hyaline fibromatosis (JHF [MIM #228600]) is a rare mesenchymal dysplasia that is inherited in an autosomal recessive manner. This disease is characterized by joint contracture, bone deformity, gingival hypertrophy and subcutaneous fibromatosis in the back, scalp and extremities. Fibromas of JHF are histologically characterized by the deposition of amorphous hyaline material in the extracellular milieu of the dermis and soft tissues . Recently, mutations in capillary morphogenesis gene 2 (CMG2) were identified in JHF patients . CMG2 was originally identified as a gene expressed at elevated levels in human umbilical vein endothelial cells that were induced to undergo capillary formation in three-dimensional collagen matrices . Although the precise function of CMG2 is not yet known, ... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2642630 Tue, 28 Jul 2009 10:52:23 +0100 2642630 The effect of proopiomelanocortin-derived peptides on the immune system of human hair follicles http://www.medworm.com/index.php?rid=2642629&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001674%2Fabstract%3Frss%3Dyes Proopiomelanocortin (POMC) is a prohormone produces various bioactive peptides via a series of enzymatic steps in a tissue-specific manner, including adrenocorticotropin (ACTH), α-melanocyte stimulating hormone (α-MSH), and β-endorphin. POMC is expressed not only in the pituitary gland, but also in a variety of non-pituitary organs, including the skin . The functions of POMC-derived peptides in immunomodulation are still under investigation. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2642629 Tue, 28 Jul 2009 10:52:23 +0100 2642629 Xp22.3 microdeletions in three Chinese families with X-linked ichthyosis http://www.medworm.com/index.php?rid=2642628&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001595%2Fabstract%3Frss%3Dyes X-linked ichthyosis (XLI), an inborn error of metabolism due to steroid sulfatase deficiency , is caused by mutations in STS encoding the steroid sulfatase. About 90% of the XLI cases have genomic microdeletions encompassing the STS locus . Occasionally, STS deletions can extend to the neighboring genes, leading to a contiguous gene syndrome that may combine the classical XLI with mental retardation, chondrodysplasia punctata, Kallmann syndrome (KAL1), short stature, and/or ocular albinism type 1 . (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2642628 Tue, 28 Jul 2009 10:52:23 +0100 2642628 Identification of the major allergen of Malassezia globosa relevant for atopic dermatitis http://www.medworm.com/index.php?rid=2642627&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS092318110900156X%2Fabstract%3Frss%3Dyes Conclusions: MGp42 may be a cleavage product of intact HSP70. This novel M. globosa allergen could be useful for the diagnosis of AD. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2642627 Tue, 28 Jul 2009 10:52:23 +0100 2642627 Effects of hydroquinone and its glucoside derivatives on melanogenesis and antioxidation: Biosafety as skin whitening agents http://www.medworm.com/index.php?rid=2642626&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001613%2Fabstract%3Frss%3Dyes Conclusions: Deoxyarbutin exerts potent tyrosinase inhibition, lessened cytotoxicity, and certain antioxidation potential, may serve as an effective and safe alternative to hydroquinone for use in skin whitening. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2642626 Tue, 28 Jul 2009 10:52:23 +0100 2642626 HB-EGF-induced VEGF production and eNOS activation depend on both PI3 kinase and MAP kinase in HaCaT cells http://www.medworm.com/index.php?rid=2642625&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001637%2Fabstract%3Frss%3Dyes Conclusion: These results demonstrate that HB-EGF-induced eNOS activation depends on p42/p44 MAPK, PI3K/Akt pathways and endogenous VEGF in HaCaT cells. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2642625 Tue, 28 Jul 2009 10:52:23 +0100 2642625 Prevention of the ultraviolet effects on clinical and histopathological changes, as well as the heat shock protein-70 expression in mouse skin by topical application of algal UV-absorbing compounds http://www.medworm.com/index.php?rid=2642624&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001650%2Fabstract%3Frss%3Dyes Conclusion: The topical application of P-334+SH protected against UV-induced skin damage in mice and contributed to maintaining the antioxidant defence system of the skin as well as Hsp70 expression. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2642624 Tue, 28 Jul 2009 10:52:22 +0100 2642624 The dose effect of human bone marrow-derived mesenchymal stem cells on epidermal development in organotypic co-culture http://www.medworm.com/index.php?rid=2642623&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001601%2Fabstract%3Frss%3Dyes Conclusion: This study indicates the advantage of using a new skin equivalent model incorporating a small fraction of MSCs to develop biologically useful tissues for maintaining homeostasis during skin regeneration and wound healing process. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2642623 Tue, 28 Jul 2009 10:52:22 +0100 2642623 Gender-linked differences in human skin http://www.medworm.com/index.php?rid=2642622&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001649%2Fabstract%3Frss%3Dyes Conclusion: The knowledge of gender-linked cutaneous differences might help in preparing male-specific products for more appropriate dermatological treatments or cosmetic interventions. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2642622 Tue, 28 Jul 2009 10:52:22 +0100 2642622 34th Annual Meeting of the Japanese Society of Investigative Dermatology (JSID) and the JSID-Asia-Oceania-Forum on Hair Research and Stem Cells December 4-6, 2009, in Fukuoka City, Kyushu, Japan http://www.medworm.com/index.php?rid=2642621&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002230%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2642621 Tue, 28 Jul 2009 10:52:22 +0100 2642621 Editorial Board http://www.medworm.com/index.php?rid=2642620&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109002060%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2642620 Tue, 28 Jul 2009 10:52:22 +0100 2642620 Announcements http://www.medworm.com/index.php?rid=2585753&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001753%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2585753 Fri, 10 Jul 2009 10:49:30 +0100 2585753 Prevalence of atopic dermatitis in Japanese adults and community validation of the U.K. diagnostic criteria http://www.medworm.com/index.php?rid=2585752&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001224%2Fabstract%3Frss%3Dyes The objective of this current study was to confirm these results by evaluating the prevalence of adult AD in other areas of Japan, because there have been few studies in adults. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2585752 Fri, 10 Jul 2009 10:49:30 +0100 2585752 Analysis of variation in the IL7RA and IL2RA genes in atopic dermatitis http://www.medworm.com/index.php?rid=2585751&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001509%2Fabstract%3Frss%3Dyes Atopic dermatitis (AD) is a chronic inflammatory skin disease with a complex genetic background. It belongs to the group of atopic disorders that are characterized by a T helper (Th) type 2-dominated immune response. Recent evidence suggested that atopic diseases and autoimmune disorders (which are mainly Th1-driven) may not be mutually exclusive, but rather share certain risk factors that increase the development of either Th1- or Th2-immune responses to non-pathogenic antigens . (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2585751 Fri, 10 Jul 2009 10:49:30 +0100 2585751 Extensive genetic polymorphism in the haplotype STR-TNF and HLA class I with the onset and evolution of psoriasis vulgaris http://www.medworm.com/index.php?rid=2585750&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001510%2Fabstract%3Frss%3Dyes Psoriasis is an inflammatory and autoimmune disease, clinically characterized by hyperproliferation of epidermis. The cause of the disease is unknown, but one of its most consistent associations involves the Major Histocompatibility Complex (MHC) and triggering factors . Many genes are located in the MHC region and the most important is the tumor necrosis factor-alpha (TNF-α). Several polymorphisms, including microsatellites (Short Tandem Repeats – STR), were identified in the TNF-α gene found in the MHC class III region. Some studies point out that those polymorphisms are related to the production level of the TNF-α cytokine and that they play an important role in inflammatory response . In the present study, Brazilian patients with psoriasis were divided according to onset of diseas... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2585750 Fri, 10 Jul 2009 10:49:30 +0100 2585750 Inhibition of protein kinase CK2 induces E2F1 nuclear export, formation of p21/E2F1 complexes and suppression of DNA synthesis in normal human epidermal keratinocytes http://www.medworm.com/index.php?rid=2585749&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001017%2Fabstract%3Frss%3Dyes Protein kinase CK2 (formerly termed “casein kinase II”) is an extremely conserved Ser/Thr kinase, which is ubiquitously distributed in eukaryotic cells. CK2 is quite unique enzyme, strongly distinguished from others protein kinases by particularly two properties—high constitutive activity and lack of an acute mechanism/s of regulation. The extreme pleiotropy (with list of over 300 substrates) is another of its characteristic . Despite of the gaps in understanding of precise molecular mechanisms the importance of CK2 in the context of signal transduction, gene expression and respectively in the cell regulation, including the maintenance of cell cycle is incontestable. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2585749 Fri, 10 Jul 2009 10:49:29 +0100 2585749 Higher density of label-retaining cells in gingival epithelium http://www.medworm.com/index.php?rid=2585748&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109000942%2Fabstract%3Frss%3Dyes Epithelial sheets made of cultured oral mucosal epithelial cells have been used to treat various epithelial defects . These epithelial sheets are derived from oral epithelial stem cells exhibiting high proliferation potential. In the skin, research into the keratinocyte stem cell niche has advanced remarkably. However, the oral mucosal stem cell niche is less well understood. Thus, we investigated the density of label-retaining cells (LRC) in different areas of oral mucosa to elucidate the localization of oral mucosal stem cells. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2585748 Fri, 10 Jul 2009 10:49:29 +0100 2585748 Photodynamic therapy using a novel photosensitizer, EC036, is more effective compared with ATX-S10(Na) photodynamic therapy http://www.medworm.com/index.php?rid=2585747&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109000966%2Fabstract%3Frss%3Dyes Photodynamic therapy (PDT) is a new therapeutic modality for a variety of skin neoplasms, and that using 5-aminolevulinic acid (ALA) has been approved for the treatment of the actinic keratosis in the US . (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2585747 Fri, 10 Jul 2009 10:49:29 +0100 2585747 Autosomal recessive congenital ichthyosis and congenital hypothyroidism in a Tunisian patient with a nonsense mutation in TGM1 http://www.medworm.com/index.php?rid=2585746&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001534%2Fabstract%3Frss%3Dyes Autosomal recessive congenital ichthyosis (ARCI) is a rare (1:100,000–250,000), clinically and genetically heterogeneous group of cornification diseases. Phenotypes vary from severe lamellar ichthyosis (LI) to mild non-bullous congenital ichthyosiform erythroderma (NBCIE). Approximately 55% of ARCI patients have complete or partial transglutaminase 1 (TGase1) deficiency due to germline mutations in the TGM1 gene . TGase1 cross-links several precursor proteins (e.g., involucrin) and hydroxyceramides to form the cornified cell envelope. Over 100 different ARCI-mutations have been identified in TGM1, on chromosome 14q11.2, and these are more often associated with LI than NBCIE . (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2585746 Fri, 10 Jul 2009 10:49:29 +0100 2585746 A novel U2HR non-synonymous mutation in a Chinese patient with Marie Unna Hereditary Hypotrichosis http://www.medworm.com/index.php?rid=2585745&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001480%2Fabstract%3Frss%3Dyes Marie Unna Hereditary Hypotrichosis (MUHH; OMIM 146550) is a rare autosomal dominant hair loss disorder characterized by coarse, wiry, twisted hair developed in early childhood and followed by the development of alopecia. This disease was firstly described in 1925 by Marie Unna in a seven-generation of North German family . (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2585745 Fri, 10 Jul 2009 10:49:29 +0100 2585745 DNA microarray analyses and interactomic predictions for atopic dermatitis http://www.medworm.com/index.php?rid=2585744&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001236%2Fabstract%3Frss%3Dyes Atopic dermatitis (AD) is a common chronic inflammatory skin disease found in children and adults, and it is characterized by severe itching with typical skin lesions. Although most patients with AD have high concentrations of total and allergen-specific serum IgE levels, and positive skin prick test reactions to common environmental allergens, a subgroup of AD patients suffers from skin lesions without sensitization to aero- or food allergens. This analogy uses the term “intrinsic type of AD” (ADi) synonymously with “nonallergic AD”, “nonatopic eczema”, or “nonatopic AD” and as a counterpart to the term “extrinsic type of AD” (ADe). ADe has a Th2 cell mediated high serum IgE level and this condition is associated with IgE-mediated sensitization; this is seen in 70–80... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2585744 Fri, 10 Jul 2009 10:49:29 +0100 2585744 HPV16E7 tumor antigen modified by KDEL sequence induce specific cytotoxic T lymphocytes-dependent antitumor immunity http://www.medworm.com/index.php?rid=2585743&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001479%2Fabstract%3Frss%3Dyes Conclusions: The ER retrieval signal-mediated antigen delivery system may have important clinical application for cancer therapy, even virus infectious disease and autoimmune disease. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2585743 Fri, 10 Jul 2009 10:49:28 +0100 2585743 Subcellular localization of desmosomal components is different between desmoglein3 knockout mice and pemphigus vulgaris model mice http://www.medworm.com/index.php?rid=2585742&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001522%2Fabstract%3Frss%3Dyes Conclusion: These results showed the functional blocking of Dsg3 by autoantibody binding and the genetic defect of Dsg3 to induce different changes in the cytoplasmic desmosomal plaque proteins. A decrease in the level of plakoglobin is therefore not involved in the acantholysis in the PV model mice. The desmoplakin shift from the desmosomal plaque, which is induced by autoantibody binding under in vivo conditions in the PV model mouse, could be an early molecular change before the occurrence of acantholysis. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2585742 Fri, 10 Jul 2009 10:49:28 +0100 2585742 Immunohistochemical survey of the distribution of epidermal melanoblasts and melanocytes during the development of UVB-induced pigmented spots http://www.medworm.com/index.php?rid=2585741&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001005%2Fabstract%3Frss%3Dyes Conclusion: Our results indicate that chronic UVB irradiation induces differentiation and proliferation of melanoblasts, followed by an increase of differentiated melanocytes, leading to the development of pigmented spots. The sequence of expression of markers appeared to be c-kit, TRP-2, TRP-1, and finally melanin, as it is during normal melanocyte differentiation. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2585741 Fri, 10 Jul 2009 10:49:28 +0100 2585741 Reciprocal regulation of LOX and LOXL2 expression during cell adhesion and terminal differentiation in epidermal keratinocytes http://www.medworm.com/index.php?rid=2585740&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS092318110900098X%2Fabstract%3Frss%3Dyes Conclusion: LOX expression in cultured keratinocytes is related to keratinization whereas LOXL2 expression is related to cell–matrix interaction. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2585740 Fri, 10 Jul 2009 10:49:27 +0100 2585740 Exposure of human keratinocytes to ischemia, hyperglycemia and their combination induces oxidative stress via the enzymes inducible nitric oxide synthase and xanthine oxidase http://www.medworm.com/index.php?rid=2585739&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001492%2Fabstract%3Frss%3Dyes Conclusion: iNOS and XO play a major role in IRI and hyperglycemia. Inhibition of one of these enzymes may be beneficial to skin cells under these conditions. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2585739 Fri, 10 Jul 2009 10:49:27 +0100 2585739 The molecular pathology of rosacea http://www.medworm.com/index.php?rid=2585738&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001285%2Fabstract%3Frss%3Dyes This article discusses the possible molecular mechanisms for the pathogenesis of rosacea from current clinical observations and laboratory research. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2585738 Fri, 10 Jul 2009 10:49:26 +0100 2585738 Editorial Board http://www.medworm.com/index.php?rid=2585737&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001704%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2585737 Fri, 10 Jul 2009 10:49:26 +0100 2585737 Announcements http://www.medworm.com/index.php?rid=2437683&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001467%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2437683 Thu, 28 May 2009 00:57:27 +0100 2437683 Erratum to “Prevalence of obesity/adiposity in Japanese psoriasis patients: Adiposity is correlated with the severity of psoriasis” [J. Dermatol. Sci. 54 (2009) 61–63] http://www.medworm.com/index.php?rid=2437682&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001212%2Fabstract%3Frss%3Dyes Although epidemiologic survey revealed an association between psoriasis and obesity/adiposity , no reports are present on the relationship in Japanese psoriasis patients. Obesity induces overproduction of inflammatory cytokines such as tumor necrosis factor α (TNF-α), interleukin (IL)-6, and IL-8 in adipose tissue. The serum levels of TNF-α, IL-6, and IL-8 are increased in psoriasis and are associated with the disease severity . Adipocytes also produce leptin, which acts primarily through the specific receptors at hypothalamus . Leptin decreases appetite and increases energy expenditure and serum levels of leptin are known to reflect the body fat mass . Adiponectin is another adipocyte-specific secretary protein abundantly present in circulation. Plasma levels of adiponectin are paradox... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2437682 Thu, 28 May 2009 00:57:25 +0100 2437682 Introduction to Erratum http://www.medworm.com/index.php?rid=2437681&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001200%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2437681 Thu, 28 May 2009 00:57:24 +0100 2437681 Retrospective study of clinical and laboratory features in Japanese scleroderma patients with cardiac involvement http://www.medworm.com/index.php?rid=2437680&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109000917%2Fabstract%3Frss%3Dyes Cardiac involvement in systemic sclerosis (SSc), so called the scleroderma heart, is frequent visceral complications that can affect the prognosis of the disease . Because it can be clinically silent , electrocardiography or echocardiography is usually operated to detect the presence of cardiac involvement. However, abnormal findings of these examinations and frequency of them in each report have varied considerably . Thus, findings characteristic of cardiac involvement are not conclusive. In the present study, we evaluated the frequency and type of abnormal findings on electrocardiography or echocardiography, and compared them with those of age/sex-matched healthy controls. Furthermore, to determine whether the presence of cardiac involvement can be predicted from the presence of other co... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2437680 Thu, 28 May 2009 00:57:20 +0100 2437680 Zinc finger protein 28 as a novel melanoma-related molecule http://www.medworm.com/index.php?rid=2437679&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109000656%2Fabstract%3Frss%3Dyes Since melanoma is an aggressive cancer with highly metastatic ability, the increase in its incidence is a threat to public health. Therefore, it is important to find new biomarkers and effective therapies. The c-RET proto-oncogene encodes a receptor-tyrosine kinase, and glial cell line-derived neurotrophic factor (GDNF)-related ligands, including GDNF, neurturin, artemin and persephin, have been reported to be ligands of RET . RFP-RET is a hybrid oncogene between c-RET and RFP, and its kinase activity is highly up-regulated compared with the activity of c-RET tyrosine kinase . Previously, we established a metallothionein-I/RFP-RET-transgenic mouse of line 304/B6 (RET-mice) , in which systemic skin melanosis, benign melanocytic tumor(s) and malignant melanoma stepwise develop . The transgen... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2437679 Thu, 28 May 2009 00:57:08 +0100 2437679 Bosentan increases serum IL-12 levels in systemic sclerosis patients with pulmonary arterial hypertension http://www.medworm.com/index.php?rid=2437678&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109000644%2Fabstract%3Frss%3Dyes Systemic sclerosis (SSc) is a connective tissue disorder characterized by excessive fibrosis of the skin and various internal organs. Although the pathogenesis of SSc remains unknown, cytokines have been suggested to play an important role. T helper 1 (Th1) cytokines generally decrease extracellular matrix deposition, whereas Th2 cytokines increase it. Pulmonary arterial hypertension (PAH) is one of the major causes of mortality in SSc. A possible mechanism of PAH is dysregulation of endothelin (ET) system. ET-1 is a potent vasoconstrictor and biological activity of ET-1 is mediated by two different cellular receptors: ET-A and ET-B. Bosentan, an orally active dual endothelin receptor agonist (ERA), is the first ERA to show efficacy in placebo-controlled clinical trials and is approved for... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2437678 Thu, 28 May 2009 00:56:55 +0100 2437678 A novel OSMR mutation in familial primary localized cutaneous amyloidosis in a Japanese family http://www.medworm.com/index.php?rid=2437677&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109000875%2Fabstract%3Frss%3Dyes Primary localized cutaneous amyloidosis (PLCA) is a pruritic skin disorder in which there is deposition of amyloid material in the papillary dermis. Clinically, skin lesions comprise small, flat-top papules (lichen amyloidosis) or brown-gray macules (macular amyloidosis). Organs other than skin are not involved. The “amyloid” in PLCA probably represents a combination of degenerate keratin filaments from apoptotic basal keratinocytes, and deposition of serum amyloid P component and immunoglobulins . PLCA is relatively common in South America and Asia, and some cases have an autosomal dominant family history (familial PLCA, FPLCA) [MIM 105250]. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2437677 Thu, 28 May 2009 00:56:43 +0100 2437677 Serum high molecular weight adiponectin levels are decreased in psoriasis patients http://www.medworm.com/index.php?rid=2437676&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109000577%2Fabstract%3Frss%3Dyes Adiponectin is a family of adipokines, which is a group of cytokines mainly secreted by adipose tissue. Adiponectin is a regulator of insulin sensitivity and metabolism and serum adiponectin is closely related to metabolic syndrome . Metabolic syndrome has been reported to be associated with an increased risk of psoriasis or its increased severity. Indeed, psoriasis patients have higher prevalences of obesity, hypertension, diabetes and cardiovascular diseases than healthy controls . (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2437676 Thu, 28 May 2009 00:56:34 +0100 2437676 Comparison of keratin expression in cultured human adenocarcinoma cell lines http://www.medworm.com/index.php?rid=2437675&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109000553%2Fabstract%3Frss%3Dyes Adenocarcinoma is a cancer arising from various glandular tissues, possibly derived from epithelial cells of the breast, colon, lung, prostate, stomach, pancreas, cervix, or vagina. As implied by its developmental origins, epithelial tissues – keratins (Ks) – might be expressed in the adenocarcinoma or cultured cell lines. Although some K subunits might also be expressed in cultured adenocarcinoma cell lines, few reports have described K expression data . (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2437675 Thu, 28 May 2009 00:56:26 +0100 2437675 Development of a hyaluronan bioconjugate for the topical treatment of melanoma http://www.medworm.com/index.php?rid=2437674&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS092318110900067X%2Fabstract%3Frss%3Dyes Hyaluronan (HA) is a glycosaminoglycan. Despite its high molecular weight, Brown et al. has shown that topically applied HA rapidly disseminated throughout the epidermis and reached the dermis in both mouse and human skin . Importantly, the majority of cutaneous malignant melanomas are positive for the HA receptor, CD44 . We envisioned that HA conjugated to anti-cancer drugs would be useful for: (1) transport of the drug into the skin after topical application, and (2) targeted delivery of the drug to CD44 positive malignant melanoma cells. To test this concept, we conjugated doxorubicin (DOX) to HA and tested its impact on B16-F10 melanoma cells in vitro and in vivo. We used DOX because of its intrinsic fluorescence and the availability of anti-DOX antibodies. Thus, DOX-HA could be evalua... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2437674 Thu, 28 May 2009 00:56:18 +0100 2437674 The role of apoptosis and cell-proliferation regulating genes in mycosis fungoides http://www.medworm.com/index.php?rid=2437673&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS092318110900053X%2Fabstract%3Frss%3Dyes In this study, we searched for genetic alterations in the p53, Fas, Bcl-2, c-myc and Ras genes in skin samples of patients with MF and its precursor condition, large plaque parapsoriasis. Obtained results were further correlated with clinical and follow-up data. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2437673 Thu, 28 May 2009 00:56:11 +0100 2437673 Increased interferon-γ, interleukin-12p40 and IL-8 production in Propionibacterium acnes-treated peripheral blood mononuclear cells from patient with acne vulgaris: Host response but not bacterial species is the determinant factor of the disease http://www.medworm.com/index.php?rid=2437671&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109000863%2Fabstract%3Frss%3Dyes Conclusions: The inflammatory response of acne appears to be attributable to P. acnes-induced host immune response rather than P. acnes strains from normal skin or acne lesions. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2437671 Thu, 28 May 2009 00:55:58 +0100 2437671 Psoralen-ultraviolet A therapy alters epidermal Sema3A and NGF levels and modulates epidermal innervation in atopic dermatitis http://www.medworm.com/index.php?rid=2437670&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109000954%2Fabstract%3Frss%3Dyes Conclusion: PUVA therapy may reduce epidermal hyperinnervation of AD by normalization of abnormal Sema3A and NGF expression in the epidermis. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2437670 Thu, 28 May 2009 00:55:49 +0100 2437670 Induction of eosinophil-infiltrating drug photoallergy in mice http://www.medworm.com/index.php?rid=2437669&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109000632%2Fabstract%3Frss%3Dyes Conclusion: It is suggested that eosinophilic drug photoallergy is mediated by sensitized Th2 cells and locally produced eosinophil-attracting chemokines. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2437669 Thu, 28 May 2009 00:55:29 +0100 2437669 Gene expression in canine atopic dermatitis and correlation with clinical severity scores http://www.medworm.com/index.php?rid=2437668&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109000930%2Fabstract%3Frss%3Dyes Conclusion: Genes with altered expression included those relevant to skin barrier formation and immune function, suggesting both are relevant in the pathogenesis of AD. Many of these genes reflect the proposed pathogenesis in hAD, supporting the use of dogs as a model for hAD. Furthermore, these genes may be considered suitable targets for future genetic and protein function studies in human and canine AD. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2437668 Thu, 28 May 2009 00:54:49 +0100 2437668 Phenotypic characterization of human keratinocytes in coculture reveals differential effects of fibroblasts from benign fibrous histiocytoma (dermatofibroma) as compared to cells from its malignant form and to normal fibroblasts http://www.medworm.com/index.php?rid=2437667&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109000978%2Fabstract%3Frss%3Dyes Conclusion: Fibroblasts prepared from benign fibrous histiocytoma were biologically active on keratinocytes in a particular manner. Our results on fibroblast activity are suggested to be relevant for morphologic differences observed in vivo between normal epidermis and epidermis adjacent to the studied tumor types. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2437667 Thu, 28 May 2009 00:53:51 +0100 2437667 The effects of topically applied glycolic acid and salicylic acid on ultraviolet radiation-induced erythema, DNA damage and sunburn cell formation in human skin http://www.medworm.com/index.php?rid=2437665&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109000991%2Fabstract%3Frss%3Dyes Conclusions: Short-term topical application of glycolic acid in a cosmetic formulation increased the sensitivity of human skin to SSR, while a comparable treatment with salicylic acid did not. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2437665 Thu, 28 May 2009 00:53:17 +0100 2437665 A possible mechanism underlying the ceramide deficiency in atopic dermatitis: Expression of a deacylase enzyme that cleaves the N-acyl linkage of sphingomyelin and glucosylceramide http://www.medworm.com/index.php?rid=2437663&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001261%2Fabstract%3Frss%3Dyes Abstract: A deficiency of ordinary ceramides in the stratum corneum is an essential etiologic factor for the dry and barrier-disrupted skin of patients with atopic dermatitis (AD). We have proposed that the mechanism underlying that deficiency involves a novel sphingolipid metabolizing enzyme, termed sphingomyelin (SM) glucosylceramide (GCer) deacylase, which hydrolyzes SM or GCer at the acyl site to yield their lysoforms sphingosylphosphorylcholine (SPC) or glucosylsphingosine (GSP) instead of ceramide, leading to the ceramide deficiency in the AD skin. The enzymic characteristics observed showed a pH dependency of catalytic activity with a peak at pH 5.0 and a molecular weight of 40,000. Analytical isoelectric focusing (IEF) chromatography demonstrated that the pI values of SM deacylase,... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2437663 Thu, 28 May 2009 00:52:44 +0100 2437663 Editorial Board http://www.medworm.com/index.php?rid=2437662&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001315%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2437662 Thu, 28 May 2009 00:52:40 +0100 2437662 Announcements http://www.medworm.com/index.php?rid=2391463&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109001091%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2391463 Thu, 07 May 2009 13:48:10 +0100 2391463 Transcriptional activity of genes coding transforming growth factor β-1 and its receptors in patients with systemic sclerosis and Raynaud phenomenon http://www.medworm.com/index.php?rid=2391462&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181109000516%2Fabstract%3Frss%3Dyes Systemic sclerosis (SSc) is a disease of the connective tissue characterized by vascular changes and immunological dysfunctions which lead to progressive skin and internal organ fibrosis. The main role in the fibrosis processes could be played by transforming growth factor β-1 (TGFβ-1) produced in excess by peripheral blood mononuclear cells (PBMC) . Research up to date showed that TGFβ-1 has most significance in early development stage of SSc . However data concerning the role of TGFβ-1 in patients with an isolated Raynaud's phenomenon (RP) which is usually the first symptom of SSc are insufficient. In regard of numerous problems connected with evaluation of TGFβ-1 in serum of patients with SSc , the aim of this study was to investigate the changes in the number of mRNA copies of gen... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2391462 Thu, 07 May 2009 13:48:09 +0100 2391462 Polymorphisms of MTHFR gene associated with livedoid vasculopathy in Taiwanese population http://www.medworm.com/index.php?rid=2391461&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181108003897%2Fabstract%3Frss%3Dyes In this study, we investigated the allele and genotype frequencies of MTHFR C677T, A1298C, PAI-1 4G/5G insertion–deletion, factor V-Leiden, and PRT G20210A in LV patients and subjects without LV history. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=2391461 Thu, 07 May 2009 13:48:05 +0100 2391461