MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Journal of Dermatological Science' source. Wed, 08 Feb 2012 13:12:32 +0100 http://www.medworm.com/index.php?rid=5659857&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181112000266%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5659857 Wed, 01 Feb 2012 05:00:00 +0100 5659857 http://www.medworm.com/index.php?rid=5659856&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181112000126%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5659856 Wed, 01 Feb 2012 05:00:00 +0100 5659856 http://www.medworm.com/index.php?rid=5659863&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111003574%2Fabstract%3Frss%3Dyes Conclusions: This study suggests that decreased IDPc expression renders melanocytes more vulnerable to oxidative stress, and IDPc plays an important antioxidant function in melanocytes. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5659863 Tue, 24 Jan 2012 05:00:00 +0100 5659863 http://www.medworm.com/index.php?rid=5659866&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111003641%2Fabstract%3Frss%3Dyes Conclusion: We propose a model for cytoskeletal modulation in the IRS of anagenic hair follicles: AHF latches onto the keratin bundles by its C-terminus and rearranges the keratin meshwork by intrinsic cohesive activity for the granule formation. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5659866 Thu, 19 Jan 2012 05:00:00 +0100 5659866 http://www.medworm.com/index.php?rid=5659861&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111003392%2Fabstract%3Frss%3Dyes Conclusion: We conclude that linear epitopes do not play a major pathogenic role in human PV. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5659861 Thu, 19 Jan 2012 05:00:00 +0100 5659861 http://www.medworm.com/index.php?rid=5659864&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS092318111100363X%2Fabstract%3Frss%3Dyes Conclusion: Our results imply that EC-SOD plays a role not only as a reactive oxygen species scavenger, but also as a pro-apoptotic factor via COX-2/galectin-7 pathways in the epidermis. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5659864 Tue, 17 Jan 2012 05:00:00 +0100 5659864 http://www.medworm.com/index.php?rid=5659871&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111003379%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5659871 Thu, 12 Jan 2012 05:00:00 +0100 5659871 http://www.medworm.com/index.php?rid=5659869&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111003525%2Fabstract%3Frss%3Dyes We read with interest the original paper by Saleh et al. published recently in vol. 62:169–75. Here we share our experience with this type VII collagen ELISA (kindly supplied by Medical and Biological Laboratories CO., LTD, Nagoya, Japan) for the diagnosis of epidermolysis bullosa acquisita (EBA)/bullous lupus erythematosus (BLE). (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5659869 Fri, 06 Jan 2012 05:00:00 +0100 5659869 http://www.medworm.com/index.php?rid=5659868&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111003252%2Fabstract%3Frss%3Dyes Histone acetylation plays key roles in modulating chromatin structure and controlling the gene expression. It is widely accepted that densely packed DNA structure is related to histone acetylation status. Histone acetylation is a dynamic process controlled by the antagonistic actions of two classes of enzymes – the histone acetyltransferases (HATs) and the histone deacetylases (HDACs), which function to add acetyl groups or removed them from target histones, respectively . The balance between the actions of HATs and HDACs represents a key epigenetic regulatory mechanism in the gene expression regulations, which controls numerous developmental processes, biological pathways and disease states . Inhibition of HDACs has been shown to modulate gene transcription, induce growth arrest and apo... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5659868 Thu, 05 Jan 2012 05:00:00 +0100 5659868 http://www.medworm.com/index.php?rid=5659870&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111003549%2Fabstract%3Frss%3Dyes Autosomal recessive congenital ichthyoses (ARCI) include several subtypes: harlequin ichthyosis (HI), lamellar ichthyosis (LI) and congenital ichthyosiform erythroderma (CIE). To date, six causative genes have been identified in ARCI patients: ABCA12, TGM1, NIPAL4, CYP4F22, ALOXE3 and ALOX12B . The localization of transglutaminase 1, ABCA12 and 12R-lipoxygenase have been analyzed using samples from patients and model mice . However, as for NIPAL4, CYP4F22, and lipoxygenase-3, neither localization nor function has been fully clarified yet. Herein, we investigate the expression pattern and localization of NIPAL4, CYP4F22 and lipoxygenase-3 in developing human epidermis and primary cultured normal human keratinocytes. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5659870 Tue, 03 Jan 2012 05:00:00 +0100 5659870 http://www.medworm.com/index.php?rid=5659867&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111003264%2Fabstract%3Frss%3Dyes Dystrophic epidermolysis bullosa (DEB) is a genodermatosis characterized by trauma-induced blister formation beneath the lamina densa and healing with scarring. In addition, patients often have nail dystrophy, pseudosyndactyly, corneal erosions, oesophageal strictures, anaemia and excessive caries . (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5659867 Tue, 03 Jan 2012 05:00:00 +0100 5659867 http://www.medworm.com/index.php?rid=5659860&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111003161%2Fabstract%3Frss%3Dyes Conclusions: Our work showed that monitoring the dermal heating status of RF and following up the detailed process of tissue reaction can be imaged and quantified with multiphoton microscopy non-invasively in vivo. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5659860 Tue, 03 Jan 2012 05:00:00 +0100 5659860 http://www.medworm.com/index.php?rid=5659862&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111003537%2Fabstract%3Frss%3Dyes Abstract: Background: Chemicals with a molecular weight (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5659862 Fri, 30 Dec 2011 05:00:00 +0100 5659862 http://www.medworm.com/index.php?rid=5544645&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111003410%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5544645 Wed, 28 Dec 2011 09:14:05 +0100 5544645 http://www.medworm.com/index.php?rid=5544644&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111003306%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5544644 Wed, 28 Dec 2011 09:14:05 +0100 5544644 http://www.medworm.com/index.php?rid=5659865&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111003276%2Fabstract%3Frss%3Dyes Conclusion: These results indicate that TGF-β1, IFN-γ, IL-6, and IL-22 induce PDPN-expression of keratinocytes, which might be significantly involved in the wound healing process as well as in the pathomechanism of hyperproliferative psoriatic epidermis. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5659865 Thu, 22 Dec 2011 05:00:00 +0100 5659865 http://www.medworm.com/index.php?rid=5544647&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111003239%2Fabstract%3Frss%3Dyes Abstract: Chemokine receptors are G-protein-coupled, seven-transmembrane-spanning surface receptors that play key roles in cell trafficking, cell motility, and survival. These receptors are activated by small molecular weight chemotactic cytokines called chemokines. Chemokine receptors and their corresponding chemokine ligands play roles in the migration and localization of normal T cells (and other cells) during physiological responses in inflamed or infected skin. In psoriasis, the chemokine receptor CCR6 is expressed on the Th17 cells and γδ T cells, which produce a variety of cytokines (IL17 and IL22 among others), that play a role in the immunological activation. CCR6 and its ligand, CCL20, are highly expressed in psoriatic skin lesion and CCR6 is essential for the development of th... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5544647 Fri, 16 Dec 2011 05:00:00 +0100 5544647 http://www.medworm.com/index.php?rid=5544659&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111003240%2Fabstract%3Frss%3Dyes The order of the author names was incorrect in the published version of this Letter to the Editor. Please find the correct list of authors and their affiliations above. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5544659 Thu, 15 Dec 2011 05:00:00 +0100 5544659 http://www.medworm.com/index.php?rid=5544646&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111003185%2Fabstract%3Frss%3Dyes On December 10, 2011, I resigned my post as the President of the Japanese Society of Investigative Dermatology (JSID). I assumed the office in May 2008, when the International Investigative Dermatology (IID) 2008 meeting was successfully held in Kyoto. Therefore, my term was 3 years and 7 months, which is slightly longer than the usual 3-year term. Beginning in 2005, I served as the Secretary-General of the JSID under Professor Shinji Shimada, the former President, and I worked to organize the IID2008. I believe that the success of that event contributed to firmly establishing the status of the JSID in the arena of international investigative dermatological science. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5544646 Thu, 15 Dec 2011 05:00:00 +0100 5544646 http://www.medworm.com/index.php?rid=5544652&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111003136%2Fabstract%3Frss%3Dyes Conclusions: Epidermogenesis suppressed α-SMA expression in the fibroblast-rich dermal matrix, except near the dermal–epidermal junction. The α-SMA-positive cells at the dermal–epidermal junction contributed to the hyperproliferative phenotype of the epidermis. In contrast, the hyperproliferative epidermis expressed more TGF-β1, which is responsible for myofibroblast differentiation. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5544652 Mon, 12 Dec 2011 05:00:00 +0100 5544652 http://www.medworm.com/index.php?rid=5659858&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111003197%2Fabstract%3Frss%3Dyes Abstract: Transient receptor potential vanilloid 1 (TRPV1) is a member of the nonselective cationic channel family. Activation of TRPV1 induces an influx of divalent and monovalent cations (i.e., Ca2+, Na+, and Mg2+) which are activated by capsaicin, heat, and acid. TRPV1 is known to be expressed in the epidermis, but little is known about the physiological significance and functional role of TRPV1 in skin.Recent studies suggested that heat- and ultraviolet (UV)-induced matrix metalloproteinases-1 (MMP-1) expression may be partly mediated by TRPV1 activation in human keratinocytes. Also, heat and UV increased expression of TRPV1 proteins in human skin in vivo. TRPV1 protein was expressed more in the sun-protected (upper-inner arm) skin of the elderly than in young subjects. In addition, th... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5659858 Fri, 09 Dec 2011 05:00:00 +0100 5659858 http://www.medworm.com/index.php?rid=5544655&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111003124%2Fabstract%3Frss%3Dyes Bioactive peptides are short chains of amino acids that can trigger various cellular processes with protein interactions. When compared to monoclonal antibody drugs that also target protein interactions, bioactive peptides are easier to deliver and can access intracellular proteins. In addition, peptides composed of natural L-amino acids are generally not immunogenic and are readily broken down into individual natural amino acids . With the development of non-invasive transdermal delivery methods , topical peptides have become new options for the treatment of skin problems. These compounds also comprise a rapidly expanding category of cosmeceuticals because they can modify many natural processes such as cell proliferation, inflammation, and protein synthesis . (Source: Journal of Dermatolo... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5544655 Fri, 09 Dec 2011 05:00:00 +0100 5544655 http://www.medworm.com/index.php?rid=5544657&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111003070%2Fabstract%3Frss%3Dyes IL-33 is a member of the IL-1 family that signals through a heterodimer receptor complex comprising an IL-33-specific ST2L and IL-1R accessory protein (IL-1RAcP) , which is shared by other members of the IL-1 family. ST2L is expressed on activated mast cells , T helper type 2 (Th2) lymphocytes, basophils, eosinophils, NK and NKT cells, dendritic cells, and neutrophils . (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5544657 Mon, 21 Nov 2011 05:00:00 +0100 5544657 http://www.medworm.com/index.php?rid=5544650&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111003082%2Fabstract%3Frss%3Dyes Conclusions: Although more remains to be clarified, these results may support the clinical application of LED for immune regulation. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5544650 Mon, 21 Nov 2011 05:00:00 +0100 5544650 http://www.medworm.com/index.php?rid=5659859&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002891%2Fabstract%3Frss%3Dyes Conclusion: Iron chelators, non-metal binding hypoxia mimetics, and hypoxia all inhibit TNFα-mediated VCAM-1 expression. Inhibition is mediated independent of nuclear translocation of NF-κB, appears to target TNFα-mediated chromatin modifications, and is at least partially dependent upon HIF expression. The absence of complete VCAM-1 expression rescue with HIF silencing implies an important regulatory role for an Fe(II)/α-ketoglutarate dioxygenase distinct from the prolyl and asparagyl hydroxylases that control HIF function. Identification of this dioxygenase may provide a valuable target for modulating inflammation in human tissues. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5659859 Thu, 17 Nov 2011 05:00:00 +0100 5659859 http://www.medworm.com/index.php?rid=5387005&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002982%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5387005 Thu, 10 Nov 2011 07:13:11 +0100 5387005 http://www.medworm.com/index.php?rid=5386989&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002945%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5386989 Thu, 10 Nov 2011 07:13:11 +0100 5386989 http://www.medworm.com/index.php?rid=5544656&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002878%2Fabstract%3Frss%3Dyes We examined whether these molecules affected keratinocyte proliferation and differentiation. In vitro proliferation of normal human keratinocytes (NHKs) was inhibited by indigo naturalis, indirubin, and E804, but not by indigo (A). This result suggested that indirubin, but not indigo, represented the active component within indigo naturalis. Furthermore, the activity of E804 on keratinocyte proliferation was 10-fold more potent than that of indirubin. We have previously demonstrated that a Stat3 inhibitor, STA-21, inhibited the proliferation but induced differentiation of NHKs in vitro . Involucrin was up-regulated in the mRNA and protein level by stimulation with indirubin and E804, which had a similar effect to STA-21 (B and C). In contrast, transcript levels of K10 were increased by E80... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5544656 Thu, 03 Nov 2011 04:00:00 +0100 5544656 http://www.medworm.com/index.php?rid=5544649&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS092318111100291X%2Fabstract%3Frss%3Dyes Conclusion: These results suggest that though most AMPs are expressed in DFU, this production is not appropriate to promote wound healing and contain secondary infections. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5544649 Wed, 02 Nov 2011 04:00:00 +0100 5544649 http://www.medworm.com/index.php?rid=5544658&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS092318111100288X%2Fabstract%3Frss%3Dyes Acral peeling skin syndrome (APSS, OMIM #609796) is a rare autosomal recessive disorder characterized by superficial exfoliation and blistering of hands and feet . The level of separation is at the junction of the stratum granulosum and stratum corneum . Onset of symptoms is shortly after birth or in early childhood. Exfoliation can be provoked by heat, humidity and friction. The resulting lesions usually heal without scarring, often leaving residual erythema . (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5544658 Mon, 31 Oct 2011 04:00:00 +0100 5544658 http://www.medworm.com/index.php?rid=5544651&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002908%2Fabstract%3Frss%3Dyes Conclusion: Specifically in normal skin fibroblasts, β-catenin might be involved in the myofibroblasts transition and negatively regulate the TGF-β1-induced myofibroblast transition. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5544651 Mon, 31 Oct 2011 04:00:00 +0100 5544651 http://www.medworm.com/index.php?rid=5544654&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002866%2Fabstract%3Frss%3Dyes Abstract: Background: Vitiligo classification systems are often based exclusively on the number and distribution of the white patches. To what extend these classification protocols reflect possible different pathophysiological basis for vitiligo or carry any prognostic value is currently unknown.Objective: To investigate patterns of association between type of vitiligo and common disease-related variables, in order to advance on the understanding of the exact nature of different clinical forms of disease, as well as to identify features with prognostic value for clinical progression of early diagnosed vitiligo.Materials and methods: This is a cross-sectional study of a population sample from south of Brazil composed of 586 independent vitiligo-affected individuals. Different strategies of ... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5544654 Wed, 26 Oct 2011 04:00:00 +0100 5544654 http://www.medworm.com/index.php?rid=5387003&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002854%2Fabstract%3Frss%3Dyes The free radical theory of senescence holds the molecular basis of senescence is derived from the accumulation of oxidative damage resulting from excess reactive oxygen species (ROS) in cells . Hydrogen peroxide (H2O2) is a major contributor to oxidative stress and has been shown to induce senescence in normal human skin fibroblasts (NHSFs) . However, the exact molecular mechanism of cellular senescence is still unknown. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5387003 Mon, 24 Oct 2011 04:00:00 +0100 5387003 http://www.medworm.com/index.php?rid=5387001&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002775%2Fabstract%3Frss%3Dyes Vascular Ehlers-Danlos syndrome (vEDS) (OMIM #130050) is a dominantly inherited, life-threatening disorder. The clinical diagnosis is made based on four major criteria: easy bruising, thin skin with visible veins, characteristic facial features and fragility/easy rupture of arteries and internal organs (i.e., uterus or intestines) . Hypermobility is generally limited to the small joints . Other features include club foot, inguinal hernias, pneumothorax, venous varicosity and acrogeria . The first major complication (i.e., vascular or internal organ rupture) occurs in 25% of patients by 20 years of age and in more than 80% by age 40; the median survival time is 48 years . (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5387001 Mon, 24 Oct 2011 04:00:00 +0100 5387001 http://www.medworm.com/index.php?rid=5387000&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002842%2Fabstract%3Frss%3Dyes Conclusions: Variability and classification of the degree of facial skin ageing appearance were studied from this longitudinal research. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5387000 Mon, 24 Oct 2011 04:00:00 +0100 5387000 http://www.medworm.com/index.php?rid=5386993&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS092318111100260X%2Fabstract%3Frss%3Dyes In this study, we evaluated the in vitro cytotoxic effect of PDT at 5J/cm2 and 10J/cm2 of red light (633±3nm) using 5-aminolevulinic acid (ALA) and methyl aminolevulinate (MAL) with and without DW, on keloid fibroblasts compared to normal skin fibroblasts.Methods: The rate of intracellular photosensitizer (protoporphyrin IX, PPIX) generation and disintegration, reactive oxygen species (ROS) generation, LDH cytotoxicity, WST-1 cytoproliferation, apoptosis by Caspase-3 activation, mitochondrial membrane potential assessment by JC-1 aggregates, qRT-PCR, flow cytometry and In-Cell Western Blotting were performed.Results: PPIX accumulation and disintegration rate was higher in keloid than normal fibroblasts after incubation with MAL compared to ALA. Increased cytotoxicity and decreased cytopro... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5386993 Mon, 24 Oct 2011 04:00:00 +0100 5386993 http://www.medworm.com/index.php?rid=5387002&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002787%2Fabstract%3Frss%3Dyes We report our findings in this paper. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5387002 Mon, 17 Oct 2011 04:00:00 +0100 5387002 http://www.medworm.com/index.php?rid=5386999&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002829%2Fabstract%3Frss%3Dyes Conclusions: Our results indicate that heparanase-induced loss of heparan sulfate at the DEJ is involved in the pigmentation process of human skin. Consequently, heparanase inhibitors can be expected to exert a protective effect against ultraviolet exposure-induced skin pigmentation. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5386999 Mon, 17 Oct 2011 04:00:00 +0100 5386999 http://www.medworm.com/index.php?rid=5386996&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002830%2Fabstract%3Frss%3Dyes Conclusions: Using SFRP1 or inhibitors of Wnt signalling might be one of the therapeutic solutions to treat keloid scarring. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5386996 Mon, 17 Oct 2011 04:00:00 +0100 5386996 http://www.medworm.com/index.php?rid=5544648&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002817%2Fabstract%3Frss%3Dyes Conclusions: We conclude that hypoxia regulates ECM remodeling via HIF1 in EDFs, and that this may be an important determinant in the pathogenesis of equine EGT. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5544648 Fri, 14 Oct 2011 04:00:00 +0100 5544648 http://www.medworm.com/index.php?rid=5387004&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002799%2Fabstract%3Frss%3Dyes Sevaral clinical reports have suggested that hair growth is promoted by low-level laser therapy (LLLT), defined as therapy using red-beam or near-infrared laser with a wavelength of 600–1100nm and an output power of 1–500mW, since Mester et al. reported effect of LLLT on hair growth in 1967. However, the irradiation area of laser system is small, and most systems are expensive and relatively immobile. On the other hand, light emitting diode (LED) light has many advantages related to safety and superior portability compared to UV and laser therapies, because they are low-coherent, quasi-monochromatic and non-thermal. We developed a new narrow-band LED (Mignon belle LT-1 Crystalline by MIGNON BELLE CO., LTD., Osaka, Japan), and utilized this red LED (638nm with half band width 3nm) to ex... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5387004 Thu, 13 Oct 2011 04:00:00 +0100 5387004 http://www.medworm.com/index.php?rid=5386998&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002805%2Fabstract%3Frss%3Dyes Conclusion: This is the first report of the occurrence of OCA3 in Japanese population. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5386998 Thu, 13 Oct 2011 04:00:00 +0100 5386998 http://www.medworm.com/index.php?rid=5386995&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002763%2Fabstract%3Frss%3Dyes Conclusion: We demonstrated that GA, UVB, GA+UVB inhibited proliferation and induced apoptosis in HaCaT cells. The mechanisms of apoptosis induced by co-treatment of GA and UVB involve multiple pathways. The synergistic photo-toxicity may be related to cell cycle arrest and apoptosis in UVB-treated HaCaT cells. These results highlight the potential adverse effects of GA-containing cosmetic agents on human skin. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5386995 Thu, 13 Oct 2011 04:00:00 +0100 5386995 http://www.medworm.com/index.php?rid=5274004&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002672%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5274004 Mon, 03 Oct 2011 05:07:30 +0100 5274004 http://www.medworm.com/index.php?rid=5273992&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002635%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5273992 Mon, 03 Oct 2011 05:07:29 +0100 5273992 http://www.medworm.com/index.php?rid=5544653&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002568%2Fabstract%3Frss%3Dyes Conclusion: CTSB and FDFT1 are excluded as candidates for KWE. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5544653 Mon, 26 Sep 2011 04:00:00 +0100 5544653 http://www.medworm.com/index.php?rid=5386991&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002295%2Fabstract%3Frss%3Dyes Conclusion: This is the second reported case of the modifying effects of FLG null alleles on XLI and strengthens the hypothesis that filaggrin defects can synergize with STS deficiency to exacerbate the ichthyosis phenotype. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5386991 Mon, 26 Sep 2011 04:00:00 +0100 5386991 http://www.medworm.com/index.php?rid=5386994&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002593%2Fabstract%3Frss%3Dyes Conclusion: Our data suggest Dicer expression as a possible molecular marker in patients with MF and apparently indicate that miRNA(s) might be of clinical relevance in CTCL. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5386994 Wed, 21 Sep 2011 04:00:00 +0100 5386994 http://www.medworm.com/index.php?rid=5386997&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002532%2Fabstract%3Frss%3Dyes Conclusions: In conclusion, this study has revealed an important role for cav-1 as a negative regulator of MMP-1 gene expression via inhibition of Erk1/2/Ets1 signaling. Cav-1 could potentially be a therapeutic target in diseases with deregulated extracellular matrix (ECM) turnover. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5386997 Mon, 19 Sep 2011 04:00:00 +0100 5386997 http://www.medworm.com/index.php?rid=5386992&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002556%2Fabstract%3Frss%3Dyes Conclusions: Our data suggest that phenylbutyrate has dual beneficial therapeutic effects on EGFRI-enhanced acute (local inflammatory) and late (systemic immune) skin reactions. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5386992 Mon, 19 Sep 2011 04:00:00 +0100 5386992 http://www.medworm.com/index.php?rid=5274003&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002581%2Fabstract%3Frss%3Dyes We previously reported that TGF-β1 is a paracrine mediator from dermal papilla to hair follicle epithelium in the pathogenesis of androgenetic alopecia (AGA) . Because TGF-β1 can induce catagen in hair cycling , it has been suggested that it functions as a paracrine pathogenic mediator from dermal papilla in AGA. On the other hand, TGF-β1 reportedly modulates androgen receptor (AR) transactivation in the monkey kidney cell line CV-1 as well as the human prostate cell lines PC-3 and DU145 cells . However, it depends on the cell type or conditions whether TGF-β1 potentiates or represses AR . It is therefore of considerable interest to examine potential modulation by TGF-β1 and its downstream signaling for AR transcriptional activity in balding dermal papilla cells (bald DPCs). To addres... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5274003 Mon, 19 Sep 2011 04:00:00 +0100 5274003 http://www.medworm.com/index.php?rid=5274002&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002544%2Fabstract%3Frss%3Dyes Piebaldism (MIM 172800) is an autosomal dominant disorder showing localized poliosis and leukoderma of the frontal scalp, forehead, ventral trunk, and extremities. On the other hand, vitiligo is an acquired pigmentation disease, and the white patches distributed typically in an acral and periorificial regions. The depigmented regions have been believed to be stable with piebaldism because of the congenital absence of melanocytes in those regions involved, whereas, the size and the distribution of depigmented macules alters in vitiligo by a selective destruction of the melanocytes. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5274002 Mon, 19 Sep 2011 04:00:00 +0100 5274002 http://www.medworm.com/index.php?rid=5273994&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS092318111100257X%2Fabstract%3Frss%3Dyes Conclusion: We have firmly established the presence of DSP/PP in mouse and rat hair follicles by immunohistochemical/immunofluorescent staining, in situ hybridization with riboprobes and transgenic mice studies. The expression of DSP/PP in hair follicles is the first demonstration that major mineralization proteins likely may also contribute to soft tissue development. This finding opens a new avenue for future investigations into the molecular-genetic management of soft tissue development. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5273994 Mon, 12 Sep 2011 04:00:00 +0100 5273994 http://www.medworm.com/index.php?rid=5386990&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002520%2Fabstract%3Frss%3Dyes Abstract: Integral hair lipid (IHL) is bound to the keratinized cell surface to make an environmentally resistant lipid envelope. It is mainly positioned on the hair cuticle and inner root sheath. IHL in the hair follicle may regard as hair barrier to be similar to the epidermal lipid layer functioning as skin barrier. Major constituents of IHL are fatty acid, phytosphingosine, ceramide in decreasing order. Minor constituents of IHL are cholesterol, cholesterol sulfate and cholesterol oleate. Cuticle or cortical cell surface in hair are abundant in fatty acids unlike the keratinized area of epidermis or sebaceous gland, and about 30–40% of such fatty acids are composed of 18-methyl-eicosanoic acid which is known to be bound to proteins by ester or thioester bond. Various factors includin... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5386990 Fri, 09 Sep 2011 04:00:00 +0100 5386990 http://www.medworm.com/index.php?rid=5273998&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS092318111100226X%2Fabstract%3Frss%3Dyes Conclusion: Our data confirmed the association of TYR p.R402Q with SK risk in the French population, and support that rare deleterious TYR variants may also play a role in multi-factorial genetic predisposition to SK. These results should be confirmed by replications studies. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5273998 Fri, 09 Sep 2011 04:00:00 +0100 5273998 http://www.medworm.com/index.php?rid=5273997&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002519%2Fabstract%3Frss%3Dyes Conclusion: ETFB participates in the mechanoregulation of fibroblast cell number in collagen gel culture. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5273997 Wed, 07 Sep 2011 04:00:00 +0100 5273997 http://www.medworm.com/index.php?rid=5196582&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002404%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5196582 Tue, 06 Sep 2011 23:51:45 +0100 5196582 http://www.medworm.com/index.php?rid=5196566&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002362%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5196566 Tue, 06 Sep 2011 23:51:36 +0100 5196566 http://www.medworm.com/index.php?rid=5274001&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002337%2Fabstract%3Frss%3Dyes Psoriatic arthritis (PsA) is characterized by seronegative arthritis in psoriasis. The prevalence of PsA among patients with psoriasis varies widely from 6% to 42% . Recent studies from Italy and Germany, which analyzed 936 and 2009 patients with psoriasis, revealed that the prevalence rate of PsA was 7.7% and 19%, respectively . However, the prevalence of PsA is assumed to be larger than expected, since enthesitis associated with PsA can develop without symptoms or signs that are recognizable by patients themselves or the physicians. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5274001 Mon, 05 Sep 2011 04:00:00 +0100 5274001 http://www.medworm.com/index.php?rid=5273995&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002283%2Fabstract%3Frss%3Dyes Conclusions: The results indicate the complexity of anti-tumor responses mediated by adhesion molecules in primary subcutaneous tumors and pulmonary metastasis of murine experimental melanoma. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5273995 Mon, 05 Sep 2011 04:00:00 +0100 5273995 http://www.medworm.com/index.php?rid=5273993&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002325%2Fabstract%3Frss%3Dyes Abstract: Galectin-3 is highly expressed in epithelial cells including keratinocytes and is involved in the pathogenesis of inflammatory skin diseases by affecting the functions of immune cells. For example, galectin-3 can contribute to atopic dermatitis (AD) by promoting polarization toward a Th2 immune response by regulating dendritic cell (DC) and T cell functions. In addition, galectin-3 may be involved in the development of contact hypersensitivity by regulating the migratory capacity of antigen presenting cells. Galectin-3 may act as a regulator of epithelial tumor progression and development through various signaling pathways, such as inhibiting keratinocyte apoptosis through regulation of the activation status of extracellular signal-regulated kinase (ERK) and activated protein kin... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5273993 Mon, 05 Sep 2011 04:00:00 +0100 5273993 http://www.medworm.com/index.php?rid=5273999&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002258%2Fabstract%3Frss%3Dyes Conclusions: Our results indicate that EGF-induced MMP-1 expression is differentially regulated by the JNK, p38 MAPK, and PI3K/Akt pathways, and suggest that p38 MAPK negatively regulates EGF-induced MMP-1 expression by suppressing the activations of ERK and JNK. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5273999 Mon, 29 Aug 2011 04:00:00 +0100 5273999 http://www.medworm.com/index.php?rid=5273996&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002313%2Fabstract%3Frss%3Dyes Conclusion: Besides inhibiting the growth of skin pathogens, catestatin peptides may also contribute to cutaneous wound closure by enhancing keratinocyte migration and proliferation at the wound site. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5273996 Mon, 29 Aug 2011 04:00:00 +0100 5273996 http://www.medworm.com/index.php?rid=5196567&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002301%2Fabstract%3Frss%3Dyes Abstract: Sézary syndrome and erythrodermic mycosis fungoides have been recognized as part of a broader spectrum of erythrodermic cutaneous T-cell lymphoma (E-CTCL). Atopic dermatitis (AD) is the most common, chronic inflammatory skin disease and can, in its most severe form, manifest as erythroderma. It is often difficult to clinically distinguish E-CTCL from various common and benign diseases presenting as erythroderma, including AD. Differentiating E-CTCL from benign inflammatory diseases is important to ensure proper disease management, and to provide accurate prognostic information. Clinical and laboratory features, including pruritus and serum levels of soluble interleukin-2 receptor, lactate dehydrogenase (LDH), immunoglobulin E (IgE), and several chemokines, do not differentiate E... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5196567 Sun, 28 Aug 2011 23:00:00 +0100 5196567 http://www.medworm.com/index.php?rid=5274000&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002271%2Fabstract%3Frss%3Dyes In this study, we analyzed the patterns of CXCR3, CCR3, and CCR10 expression in mycosis fungoides (MF), Sezary syndrome (SS), CD30+ lymphoproliferative disorders (LPD) such as lymphomatoid papulosis (LyP) and anaplastic large cell lymphoma (ALCL), and inflammatory skin diseases. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5274000 Thu, 25 Aug 2011 04:00:00 +0100 5274000 http://www.medworm.com/index.php?rid=5196569&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002015%2Fabstract%3Frss%3Dyes Conclusions: Despite their essential role in skin maintenance, epidermal stem cells are sensitive to physiological doses of UV irradiation in vivo. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5196569 Sun, 21 Aug 2011 23:00:00 +0100 5196569 http://www.medworm.com/index.php?rid=5196581&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002246%2Fabstract%3Frss%3Dyes Apart from a well-established role of platelets in haemostasis, their activation may contribute to the development of chronic allergic inflammation . Platelets release a number of potent mediators of vasodilatation and increased vascular permeability , and chemoattractants promoting migration of leukocytes to the site of allergic inflammation . Atopic dermatitis (AD) is a chronic skin disorder of the complex pathogenesis involving immediate hypersensitivity and cellular responses, characterized by skin inflammation and itching . We hypothesized that in AD subjects, the presence of concomitant allergic disorder might enhance platelet activation. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5196581 Mon, 15 Aug 2011 23:00:00 +0100 5196581 http://www.medworm.com/index.php?rid=5196570&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002076%2Fabstract%3Frss%3Dyes Conclusion: Kinin receptors seem to be involved in the control of the keratinocyte hyperproliferative process, and non-peptide kinin receptor antagonists may be useful tools in the treatment of hyperproliferative skin disorders. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5196570 Mon, 15 Aug 2011 23:00:00 +0100 5196570 http://www.medworm.com/index.php?rid=5109569&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002143%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5109569 Wed, 10 Aug 2011 17:24:13 +0100 5109569 http://www.medworm.com/index.php?rid=5109558&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002106%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5109558 Wed, 10 Aug 2011 17:24:07 +0100 5109558 http://www.medworm.com/index.php?rid=5196573&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002064%2Fabstract%3Frss%3Dyes Conclusion: Our present results strongly suggest that carbonyl modification of the dermal protein is involved in the production of the yellowish color change that is noted in the photo-aged facial skin. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5196573 Thu, 28 Jul 2011 23:00:00 +0100 5196573 http://www.medworm.com/index.php?rid=5196578&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002052%2Fabstract%3Frss%3Dyes Darier's disease (DD, OMIM 124200) is a rare autosomal dominant hereditary skin disorder characterized by abnormal keratinization and acantholysis. The causes of DD are defects in the ATP2A2 gene on chromosome 12q23-24.1, which encodes the sarco/endoplasmic reticulum Ca2+ ATPase isoform 2 (SERCA2) . To date, at least 180 ATP2A2 mutations have been reported in DD patients, and it seems that individual affected families have their unique mutations . Here we report a novel splice-site mutation in a sporadic patient with severe DD. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5196578 Mon, 25 Jul 2011 23:00:00 +0100 5196578 http://www.medworm.com/index.php?rid=5196577&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002040%2Fabstract%3Frss%3Dyes Mutations in the ADAR1 (adenosine deaminase that act on RNA 1) gene that encodes an RNA editing enzyme have been linked to Dyschromatosis symmetrica hereditaria (DSH), a skin pigmentation disorder in humans . DSH is characterized by hyperpigmented and hypopigmented macules on the face and dorsal aspects of the extremities. More than 90 mutation sites that spread in both coding and non coding sequences on ADAR1 loci have been reported in different DSH families . The tight linkage of the ADAR1 mutations and DSH indicates a role of ADAR1 in the governing of melanin distribution or in the maintenance of skin microenvironment. Nonetheless, no experimental evidence has been obtained to demonstrate the significance of ADAR1 for skin integrity. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5196577 Mon, 25 Jul 2011 23:00:00 +0100 5196577 http://www.medworm.com/index.php?rid=5196579&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002039%2Fabstract%3Frss%3Dyes Psoriasis is a chronic inflammatory skin disease characterized by inflammatory cell infiltrates and hyperproliferation of epidermal cells. There are several types of psoriasis, including psoriasis vulgaris (PV), psoriasis guttata, psoriatic arthritis, psoriatic erythroderma, and generalized pustular psoriasis (GPP). The severity of psoriasis is commonly evaluated by clinical findings of skin and blood tests including inflammatory markers such as white blood cell count (WBC), C-reactive protein (CRP), and cytokines such as IFN-γ, IL-8, IL-12, IL-18, and VEGF . However, a more sensitive and specific marker is required to evaluate and standardize the severity of psoriatic disorders. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5196579 Thu, 21 Jul 2011 23:00:00 +0100 5196579 http://www.medworm.com/index.php?rid=5196580&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002027%2Fabstract%3Frss%3Dyes Merkel cell carcinoma (MCC) is an aggressive cutaneous tumor with a rapidly increasing incidence. Merkel cell polyomavirus (MCPyV) is a recently identified virus that may be involved in the oncogenesis of MCC . (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5196580 Tue, 19 Jul 2011 23:00:00 +0100 5196580 http://www.medworm.com/index.php?rid=5196574&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111002003%2Fabstract%3Frss%3Dyes Conclusion: Topically applied AO are stored in the SC for a short time only due to the rapid AO-depletion by desquamation, textile contact, washing and environmental stress. In contrast to topical application, the systemically applied carotenoids are stored in the body fat tissue and slowly released onto the skin surface with sweat and sebum. The combined topical and systemic application of AO represents an optimal form of protection of the AO-network. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5196574 Sun, 17 Jul 2011 23:00:00 +0100 5196574 http://www.medworm.com/index.php?rid=5196572&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001812%2Fabstract%3Frss%3Dyes We examined the immunohistochemical expression of SATB1 in CMM to determine whether it could serve as a prognostic marker.Methods: A total of 97 samples of primary CMM and controls were immunostained for SATB1. The following clinicopathologic variables were evaluated: age, gender, subtype, SATB1 expression, Breslow thickness, Clark level, presence of ulceration, lymph node metastasis, distant metastasis, and survival. Statistical analyses were performed to assess for associations. Several parameters were analyzed for survival using the Kaplan–Meier method and Cox proportional-hazards model.Results: Forty cases (85.1%) of CMM showed positive staining for SATB1 by immunohistochemistry. The intensity of SATB1 staining was significantly higher in CMM than in nevus NV and normal skin (NS) (P ... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5196572 Sun, 17 Jul 2011 23:00:00 +0100 5196572 http://www.medworm.com/index.php?rid=5196576&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001794%2Fabstract%3Frss%3Dyes Keratins and keratin-associated proteins (KAPs) constitute the major structural protein components of the hair. Regulation of their expression is critical for proper hair follicle (HF) structure and function . Therefore, it is important to fully elucidate the controls that regulate keratin expression. Although it is accepted that the expression of selected keratin genes is underlain by endocrine controls , our understanding of the complex regulation of keratin expression remains rather fragmentary. To better elucidate this regulation, human skin and HF organ culture offer an instructive, physiologically relevant research tool . (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5196576 Thu, 14 Jul 2011 23:00:00 +0100 5196576 http://www.medworm.com/index.php?rid=5196568&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001824%2Fabstract%3Frss%3Dyes Conclusion: This is the first report demonstrating that a cutaneous HPV type deregulates the expression of miRNAs. These deregulations are closely related to the UV-induced upregulation of HPV8 oncogene levels, which suggest a direct or indirect HPV8-specific effect on miRNA expression. These data presume that HPV8 interferes with the miRNA mediated gene regulation to induce tumorigenesis. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5196568 Thu, 14 Jul 2011 23:00:00 +0100 5196568 http://www.medworm.com/index.php?rid=5196571&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001800%2Fabstract%3Frss%3Dyes Conclusion: UVB irradiation elicits remarkable changes in the molecular mass of HA, as well as amount. These qualitative and quantitative changes of HA might play an important role in UVB-induced cell proliferation and differentiation. Further study will be required to resolve the mechanism of HA degradation in the epidermis. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5196571 Tue, 12 Jul 2011 23:00:00 +0100 5196571 http://www.medworm.com/index.php?rid=5109565&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001502%2Fabstract%3Frss%3Dyes Conclusion: The development of a minimally sample-destructive, label-free spectroscopy based technique that can differentiate layers of cells in the dermal papilla and connective tissue sheath in the mesenchyme of the hair follicle paves the way forward to identifying spectral markers important in wound healing and stem cell therapies. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5109565 Tue, 12 Jul 2011 23:00:00 +0100 5109565 http://www.medworm.com/index.php?rid=5109561&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001538%2Fabstract%3Frss%3Dyes Abstract: Background: Ustekinumab has been evaluated in Caucasian patients with psoriasis, but no studies have been conducted in Asian patients.Objective: To assess the efficacy and safety of ustekinumab in Taiwanese and Korean patients with moderate-to-severe psoriasis.Methods: In this 36-week, multicenter, double-blind, placebo-controlled study, 121 patients with moderate-to-severe psoriasis were randomized (1:1) to receive subcutaneous injections of ustekinumab 45mg at weeks 0, 4, 16 or placebo at weeks 0, 4 and ustekinumab 45mg at weeks 12, 16. Efficacy endpoints at week 12 included the proportion of patients achieving at least 75% improvement from baseline in Psoriasis Area and Severity Index (PASI 75; primary endpoint), proportion of patients with Physician's Global Assessment (PGA) ... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5109561 Sun, 10 Jul 2011 23:00:00 +0100 5109561 http://www.medworm.com/index.php?rid=5109567&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001514%2Fabstract%3Frss%3Dyes In this study, we investigated correlations between S. aureus presence on apparently normal skin and cutaneous conditions. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5109567 Wed, 06 Jul 2011 23:00:00 +0100 5109567 http://www.medworm.com/index.php?rid=4999342&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001897%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4999342 Wed, 06 Jul 2011 14:33:43 +0100 4999342 http://www.medworm.com/index.php?rid=4999331&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS092318111100185X%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4999331 Wed, 06 Jul 2011 14:33:37 +0100 4999331 http://www.medworm.com/index.php?rid=5196575&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001770%2Fabstract%3Frss%3Dyes Conclusions: Our data indicate that the host factors European ancestry and XPC polymorphisms contributed to melanoma risk in a region exposed to high sun radiation. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5196575 Tue, 05 Jul 2011 23:00:00 +0100 5196575 http://www.medworm.com/index.php?rid=5109566&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001769%2Fabstract%3Frss%3Dyes Tyrosinase is a membrane-bound glycoprotein, and in humans, it consists of 533 amino acids, including seven N-glycosylation sites, 17 cysteine residues grouped in two cysteine-rich domains, and two copper-binding domains . In the early N-glycan processing in the endoplasmic reticulum, multiple N-linked glycans or 14 monosaccharide residues (Glc3Man9GlcNAc2) of immature tyrosinase are trimmed sequentially by α-glucosidases I and II . Both steps can be inhibited by castanospermine, deoxynojirimycin (DNJ), and N-butyl DNJ (NB-DNJ). Nascent tyrosinase is folded by molecular chaperones, for example, calnexin and calreticulin , through their recognition of monoglucosylated N-glycans (Glc1Man9GlcNAc2), followed by the acquisition of two copper atoms in the trans-Golgi network that gives rise to ... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5109566 Sun, 03 Jul 2011 23:00:00 +0100 5109566 http://www.medworm.com/index.php?rid=5109562&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001745%2Fabstract%3Frss%3Dyes Conclusions: Psph is highly induced in proliferative normal keratinocytes and in skin tumors. PSPH appears to be critical for the proliferation of SCC cells; however, this phenomenon may not involve the phosphoserine metabolic pathway. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5109562 Sun, 03 Jul 2011 23:00:00 +0100 5109562 http://www.medworm.com/index.php?rid=5109563&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001733%2Fabstract%3Frss%3Dyes Conclusions: The depletion of LCs in the non-inflammatory warts and HPV-Bowen is associated with a down-regulation of expression levels of MIP-3α and E-cadherin in the lesional keratinocytes. MIP-3α expression is upregulated in lesional keratinocytes of inflammatory warts, with the subsequent recruitment of various DC subsets and cytotoxic T cells, whereas plasma cell-rich infiltration was induced in HPV-Bowen. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5109563 Tue, 28 Jun 2011 23:00:00 +0100 5109563 http://www.medworm.com/index.php?rid=5109564&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001757%2Fabstract%3Frss%3Dyes Conclusions: SSM enhanced IL-12 production, but suppressed TSLP expression, resulting in a shift from Th2 to Th1 responses. This shift suppressed AD-like skin lesions in a similar fashion as the BCG vaccine. Therefore, SSM may be a useful adjuvant for suppressing skin lesions in AD models. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5109564 Sun, 26 Jun 2011 23:00:00 +0100 5109564 http://www.medworm.com/index.php?rid=4999332&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001782%2Fabstract%3Frss%3Dyes Abstract: Regulatory T cells (Treg) are a subset of T cells with strong immunosuppressive activity. In the skin, it has recently been revealed that Treg play important roles not only in the maintenance of skin homeostasis but also in the regulation of the immune responses, such as contact hypersensitivity and atopic dermatitis. Furthermore, the skin plays important roles in the induction of Treg in the periphery. In this review, we will provide an overview of the mechanism of Treg-mediated immunosuppression and discuss the role of Treg in the skin. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4999332 Sun, 26 Jun 2011 23:00:00 +0100 4999332 http://www.medworm.com/index.php?rid=4999341&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001496%2Fabstract%3Frss%3Dyes The 2nd JSID-Asia-Oceania-Forum took place on December 5th, 2010, which was the 3rd day of the 35th Annual Meeting of the Japanese Society for Investigative Dermatology. In 1892, Elie Metchnikoff wrote “Leçonssur la pathologiecomparée de l’inflammation.” This landmark series of lectures, delivered at the Pasteur Institute the year before, launched the modern study of immunology and inflammation. Along with Paul Ehrlich, Metchnikoff received The Nobel Prize in Physiology for Medicine in 1908 for this work. Inflammation and immunity, self and non-self (auto or non-autoimmune), complexity and simplicity, and their interrelationships have been attracting researchers ever since. This forum offered a detailed and comprehensive overview of autoimmunity and autoinflammatory diseases, and t... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4999341 Wed, 15 Jun 2011 23:00:00 +0100 4999341 http://www.medworm.com/index.php?rid=4999336&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001204%2Fabstract%3Frss%3Dyes Conclusions: We found that DP acts through dual mechanisms to reduce melanin synthesis; by inhibition of tyrosinase activity via an anti-oxidant effect, and, more importantly, by the acceleration of tyrosinase degradation. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4999336 Wed, 15 Jun 2011 23:00:00 +0100 4999336 http://www.medworm.com/index.php?rid=5109568&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001526%2Fabstract%3Frss%3Dyes Lens epithelium-derived growth factor (LEDGF), also known as dense fine speckles 70kDa protein (DFS70), was isolated as a transcription cofactor, a survival factor and a target of autoantibodies in atopic dermatitis . LEDGF/DFS70 has been implicated as a key player in cancer . Psoriasis is a common skin disorder that is characterized by abnormal differentiation of the epidermal keratinocytes (KCs), inflammatory cells recruitment and changes in the endothelial vascular system. It has been suggested that psoriatic KCs have abnormal expression of various cytokines and chemokines, and deregulation of several signaling pathways. For example, psoriatic KCs are characterized by activation of the signal transducer and activator of transcription 3 (STAT3) . Activated TNF-α and MAPK-activated prote... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5109568 Tue, 14 Jun 2011 23:00:00 +0100 5109568 http://www.medworm.com/index.php?rid=5109559&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001484%2Fabstract%3Frss%3Dyes Conclusions: The hemodynamic response ensues the photothermal response in a thermal coagulum-independent manner and involves primary and secondary hemostasis. Primary hemostasis is mediated by constitutively expressed GPIbα but not by activation-dependent P-selectin. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5109559 Sun, 12 Jun 2011 23:00:00 +0100 5109559 http://www.medworm.com/index.php?rid=4999339&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001460%2Fabstract%3Frss%3Dyes Psoriasis is one of the most common dermatological disorders with a genetic predisposition and potentially being caused or triggered by environmental factors . Many epidemiologic studies have pointed to a significant association between smoking and psoriasis . However, to our knowledge, the meta-analysis of smoking and psoriasis has not been assessed systematically and the gender and ethnicity features of these studies have not been assessed fully to further characterize this potential association and its determinants. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4999339 Sun, 12 Jun 2011 23:00:00 +0100 4999339 http://www.medworm.com/index.php?rid=4877709&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001605%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4877709 Mon, 30 May 2011 16:23:06 +0100 4877709 http://www.medworm.com/index.php?rid=4877695&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001563%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4877695 Mon, 30 May 2011 16:23:02 +0100 4877695 http://www.medworm.com/index.php?rid=5109560&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001459%2Fabstract%3Frss%3Dyes Conclusion: The present results indicated that keratinocyte apoptosis in Sharpincpdm mice was regulated by an intrinsic caspase-dependent mitochondria pathway. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=5109560 Sun, 29 May 2011 23:00:00 +0100 5109560 http://www.medworm.com/index.php?rid=4999340&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001472%2Fabstract%3Frss%3Dyes The skin has evolved an innate chemical defense system composed of antimicrobial peptides (AMPs), which provide a rapid, direct front-line component of innate immunity . In addition to their antimicrobial properties, AMPs exhibit a variety of immunomodulatory activities in keratinocytes . Besides the enhancement of cytokine/chemokine production, the multiple functions of AMPs in keratinocytes include chemotaxis, cell proliferation and wound healing . Elafin (skin-derived antileukoprotease, SKALP) and secretory leukocyte protease inhibitor (SLPI) belong to the antileukoproteinase superfamily of proteinase inhibitors . These proteins have been detected in keratinocytes, and their expression is increased in inflamed and/or infected skin and during wound healing . Both elafin/SKALP and SLPI ex... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4999340 Sun, 29 May 2011 23:00:00 +0100 4999340 http://www.medworm.com/index.php?rid=4999338&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001381%2Fabstract%3Frss%3Dyes Protein kinase CK2 (previously called casein kinase 2) (EC 2.7.11.1) is an extremely conserved serine/threonine kinase ubiquitously distributed in mammalian cells, where typically is found as a tetramer, consisting of two catalytic subunits (α and/or α′) and a dimer of non-catalytic β subunit . CK2 is strongly distinguished from others protein kinases by particularly three properties – high constitutive activity, lack of an acute mechanism/s of regulation and extreme pleiotropy (with list of over 300 substrates). Mounting evidence supports the importance of the enzyme in diverse biological processes, especially its essential role in cell signal regulation . Although, the involvement of CK2 in cell signaling is vast-investigated, very little is known about how CK2 participates in the... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4999338 Sun, 29 May 2011 23:00:00 +0100 4999338 http://www.medworm.com/index.php?rid=4999335&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001447%2Fabstract%3Frss%3Dyes Conclusion: Results of pharmacological screenings obtained by using HaCaT should be cautiously considered while extending them to primary keratinocytes from human epidermis. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4999335 Sun, 29 May 2011 23:00:00 +0100 4999335 http://www.medworm.com/index.php?rid=4999333&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001216%2Fabstract%3Frss%3Dyes Conclusion: Our studies indicate that SR-T100 induces apoptosis of SCC cells via death receptors and the mitochondrial death pathway. The high efficacy of SR-T100 in our preclinical trial suggests that SR-T100 is a highly promising herb for AKs and related disorders. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4999333 Wed, 25 May 2011 23:00:00 +0100 4999333 http://www.medworm.com/index.php?rid=4999337&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001423%2Fabstract%3Frss%3Dyes Dyskeratosis congenita (DC) is a rare heritable disorder that is characterized by abnormal skin pigmentation, nail dystrophy and leukoplakia . The most common modes of inheritance is the X-linked DC, caused by mutations of the DKC1. Many of patients will develop BM abnormalities , and this is the major cause of premature death. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4999337 Tue, 24 May 2011 23:00:00 +0100 4999337 http://www.medworm.com/index.php?rid=4877700&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001435%2Fabstract%3Frss%3Dyes Conclusion: Transgenic expression of Dsg1 rescued the severe B6-Dsg3−/− phenotype and provided a syngeneic mouse model of PV, which may be a valuable tool for clarifying immunological mechanisms in autoimmunity and tolerance of Dsg3. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4877700 Tue, 24 May 2011 23:00:00 +0100 4877700 http://www.medworm.com/index.php?rid=4877699&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001198%2Fabstract%3Frss%3Dyes Conclusion: Our data suggest that antagonists of MC1R and MC5R could be effective sebum suppressive agents and might have a potential for the treatment of acne and other sebaceous gland pathologies. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4877699 Tue, 24 May 2011 23:00:00 +0100 4877699 http://www.medworm.com/index.php?rid=4999334&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001411%2Fabstract%3Frss%3Dyes Conclusion: The results indicate that GlcNAc inhibited UVB-induced collagenolytic MMP production by interfering with Ca2+-dependent Akt and MAPKs/AP-1 and NF-κB signaling. They may thus be potentially useful in the prevention and treatment of skin photoaging. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4999334 Thu, 19 May 2011 23:00:00 +0100 4999334 http://www.medworm.com/index.php?rid=4877708&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS092318111100137X%2Fabstract%3Frss%3Dyes The author regrets that when this paper was published the first four lines in Section 2.2 (Cell culture and UVA irradiation) contained an incorrect description. The corrected text and an additional Ref. are as follows: (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4877708 Thu, 19 May 2011 23:00:00 +0100 4877708 http://www.medworm.com/index.php?rid=4877696&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS092318111100140X%2Fabstract%3Frss%3Dyes Summary: Shared angiogenic and oxidative mechanisms underlie the pathophysiology of psoriasis and atherosclerosis. During the pathogenesis of both diseases, stimuli such as injury or local hypoxia trigger the release of pro-angiogenic factors including IL-8, HIF-1α, ETS-1, and VEGF. These factors stimulate increased permeability and encourage leukocyte transmigration into areas of inflammation by enhanced expression of cell adhesion molecules. Psoriasis and atherosclerosis also share common enzymatic sources of reactive oxygen species (ROS), and these ROS influence several cellular signaling pathways implicated in the pathogenesis of both diseases. Pharmacologic and genetic therapies that target key factors in these pathways could provide innovative approaches to the management of psorias... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4877696 Thu, 19 May 2011 23:00:00 +0100 4877696 http://www.medworm.com/index.php?rid=4831733&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001289%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4831733 Wed, 18 May 2011 16:52:14 +0100 4831733 http://www.medworm.com/index.php?rid=4831723&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001241%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4831723 Wed, 18 May 2011 16:52:10 +0100 4831723 http://www.medworm.com/index.php?rid=4877707&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001393%2Fabstract%3Frss%3Dyes We examined cases of BD of the nail apparatus for the presence of HPV genomes by polymerase chain reaction with restriction fragment length polymorphisms (PCR–RFLP) methods and direct sequencing analysis. Overall, HPV positive samples were also examined for the distribution of HPV DNA in the tissues by in situ hybridization (ISH) methods. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4877707 Tue, 17 May 2011 23:00:00 +0100 4877707 http://www.medworm.com/index.php?rid=4877701&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111000843%2Fabstract%3Frss%3Dyes Conclusions: Psoriasis was associated with a significantly increased risk of comorbidities, especially for those patients with moderate to severe disease. These health associations should be taken into consideration when evaluating the burdens of psoriasis and designing effective treatment plans. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4877701 Wed, 04 May 2011 23:00:00 +0100 4877701 http://www.medworm.com/index.php?rid=4877702&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111000922%2Fabstract%3Frss%3Dyes Conclusions: We have observed that the interplay of an environmental risk factor and one polymorphism in TP53 gene could modulate the risk of BCC. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4877702 Mon, 02 May 2011 23:00:00 +0100 4877702 http://www.medworm.com/index.php?rid=4877705&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001149%2Fabstract%3Frss%3Dyes Sjögren-Larsson syndrome (SLS) is a rare, autosomal recessive neurocutaneous disorder characterized by clinical triads, congenital ichthyoids, spasticity and mental retardation . SLS is caused by mutations in fatty aldehyde dehydrogenase (FALDH) (or ALDH3A2) gene . FALDH is a microtonal NAD-dependent enzyme, which oxidizes medium- to long-chain aliphatic aldehydes to fatty acids. Accumulation of fatty alcohol has been shown in cultured fibroblasts and in plasma from SLS patients . Numbers of mutations of FALDH gene have been shown, although only three mutations have been identified in Japanese SLS patients . We here report a SLS patient who is a homozygote for one of the known mutations. In addition to assessing skin phenotype, permeability barrier function and cutaneous morphology, bioch... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4877705 Sun, 01 May 2011 23:00:00 +0100 4877705 http://www.medworm.com/index.php?rid=4877703&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001137%2Fabstract%3Frss%3Dyes Conclusion: The results of this study support the potential use of nitroxide compounds, including novel nitroxide-based UV filters, as a useful and alternative strategy for improving the efficacy of topical formulations against photo-aging and possibly photo-carcinogenesis. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4877703 Sun, 01 May 2011 23:00:00 +0100 4877703 http://www.medworm.com/index.php?rid=4877706&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001150%2Fabstract%3Frss%3Dyes Bone morphogenetic proteins (BMPs) have been implicated in a diverse array of biological processes including development and apoptosis . Ret is involved in the physiological mechanisms of melanocyte activation and melanin production . Ret expression in enteric neural precursors is initiated shortly after they emigrate from the neural plate. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4877706 Thu, 28 Apr 2011 23:00:00 +0100 4877706 http://www.medworm.com/index.php?rid=4877704&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001162%2Fabstract%3Frss%3Dyes Recessive X-linked ichthyosis (XLRI, OMIM#308100) is a keratinization disorder due to an error of inborn metabolism and affects roughly 1:2000 to 1:6000 males . Female carriers with few exceptions do not manifest the disease. The clinical manifestations occur early in life and involve generalized dryness and scaling of the skin with polygonal, regular dark scales. The trunk, limbs, neck, ears and scalp are often involved. The affected regions are often symmetrically distributed and more evident on the extensor aspects of the limbs, but can also involve the flexural sides . Palms and soles are spared. Extracutaneous signs are described involving corneal opacities, testicular cancer, cryptorchidism and a family history of delayed progression of parturition . The disease is caused by partial ... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4877704 Thu, 28 Apr 2011 23:00:00 +0100 4877704 http://www.medworm.com/index.php?rid=4877698&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001174%2Fabstract%3Frss%3Dyes Conclusion: PCA may be useful as an active ingredient for topical applications for a hypopigmenting effect. MPC has potential as a hypopigmenting agent but requires rather invasive methods for its delivery to the target cells. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4877698 Thu, 28 Apr 2011 23:00:00 +0100 4877698 http://www.medworm.com/index.php?rid=4831731&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111000879%2Fabstract%3Frss%3Dyes In this study, proteomics analysis was performed using the sera of vitiligo patients to detect autoantigens of melanocytes related with vitiligo pathogenesis. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4831731 Wed, 27 Apr 2011 23:00:00 +0100 4831731 http://www.medworm.com/index.php?rid=4831728&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111000570%2Fabstract%3Frss%3Dyes Conclusion: Our results suggest that Sema7A on keratinocytes and β1-integrin on monocytes contribute to monocyte activation by keratinocytes within skin inflammation, such as psoriasis or wound. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4831728 Tue, 26 Apr 2011 23:00:00 +0100 4831728 http://www.medworm.com/index.php?rid=4831725&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111000521%2Fabstract%3Frss%3Dyes Conclusion: Our results strongly suggest that minoxidil extends the anagen phase by activating β-catenin activity in the DPCs. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4831725 Tue, 26 Apr 2011 23:00:00 +0100 4831725 http://www.medworm.com/index.php?rid=4831724&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111000557%2Fabstract%3Frss%3Dyes Conclusion: These results demonstrate that NQO-1 is modulated during KC differentiation via Nrf2 pathway, suggesting the active role of NQO-1 in the differentiating epidermis. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4831724 Tue, 26 Apr 2011 23:00:00 +0100 4831724 http://www.medworm.com/index.php?rid=4877697&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111000934%2Fabstract%3Frss%3Dyes Conclusion: These results suggest that apigenin attenuates dopamine-induced apoptosis in melanocytes via oxidative stress-related p38, JNK and Akt signaling and therefore could be a potential agent in treating vitiligo. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4877697 Sun, 24 Apr 2011 23:00:00 +0100 4877697 http://www.medworm.com/index.php?rid=4831726&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111000910%2Fabstract%3Frss%3Dyes Conclusion: This study demonstrates that aging enhances skin maceration. Considering that maceration is a risk factor for the skin damage, the development of technology to promote skin barrier recovery after maceration in the elderly is warranted. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4831726 Sun, 17 Apr 2011 23:00:00 +0100 4831726 http://www.medworm.com/index.php?rid=4715707&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001009%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4715707 Fri, 15 Apr 2011 17:11:10 +0100 4715707 http://www.medworm.com/index.php?rid=4715706&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001113%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4715706 Fri, 15 Apr 2011 17:11:10 +0100 4715706 http://www.medworm.com/index.php?rid=4715705&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111001083%2Fabstract%3Frss%3Dyes The Publisher regrets that this Letter to the Editor was published prior to the accompanying Regular Article, “Inhibitory effects of UV-based therapy on dry skin-inducible nerve growth in acetone-treated mice” which is published on pages 91–97 of this issue. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4715705 Fri, 15 Apr 2011 17:11:10 +0100 4715705 http://www.medworm.com/index.php?rid=4715693&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS092318111100096X%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4715693 Fri, 15 Apr 2011 17:11:07 +0100 4715693 http://www.medworm.com/index.php?rid=4831730&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111000752%2Fabstract%3Frss%3Dyes Conclusion: These intrinsic aging- and photoaging-dependent GAG changes and their correlations with water content provide new insights into the pathophysiology of dry skin in the elderly. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4831730 Sun, 10 Apr 2011 23:00:00 +0100 4831730 http://www.medworm.com/index.php?rid=4831729&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111000831%2Fabstract%3Frss%3Dyes Conclusion: Our results support the idea that ROS-dependent apoptosis in STI571-treated melanoma cells B16F0. The combination of a JNK inhibitor with STI571 for treating melanomas is suggested for further in vivo studies. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4831729 Sun, 10 Apr 2011 23:00:00 +0100 4831729 http://www.medworm.com/index.php?rid=4831727&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111000855%2Fabstract%3Frss%3Dyes Conclusion: We conclude that the NC1+NC2 ELISA can be a practical assay for the diagnosis and follow up of the antibody titers of EBA patients. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4831727 Sun, 10 Apr 2011 23:00:00 +0100 4831727 http://www.medworm.com/index.php?rid=4831732&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111000764%2Fabstract%3Frss%3Dyes Mast cells are the central players in establishing allergic inflammation. Upon IgE-dependent activation, mast cells immediately release the preformed and de novo synthesized mediators including histamine, proteases, leukotrienes, prostaglandins and cytokines, leading to acute reactions such as vasodilation, increased vascular permeability and broncho contraction. Allergic responses also trigger the influx and activation of a variety of inflammatory cells including eosinophils and lymphocytes. Rapidly released mediators and numerous cytokines produced by mast cells are strongly believed to induce and sustain these responses, which may contribute to chronic inflammation . (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4831732 Thu, 07 Apr 2011 23:00:00 +0100 4831732 http://www.medworm.com/index.php?rid=4715704&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111000788%2Fabstract%3Frss%3Dyes The clinical manifestation of extrinsic skin ageing differs between Asian and Caucasian women. It has been observed that Asian women develop pigment spots (lentigines) much earlier than age-matched Caucasian women, whereas the opposite is true for the formation of coarse wrinkles . Underlying reasons have remained enigmatic. In the present study we tested the hypothesis whether differences in sun-exposure, smoking or plasma antioxidant levels, which are all known influencing factors of skin ageing , might be associated with the regional difference in skin ageing manifestation. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4715704 Sun, 03 Apr 2011 23:00:00 +0100 4715704 http://www.medworm.com/index.php?rid=4715703&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111000806%2Fabstract%3Frss%3Dyes In this study, we determined the TSLP expression profiles of human keratinocytes after stimulation with Malassezia yeast cells. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4715703 Sun, 03 Apr 2011 23:00:00 +0100 4715703 http://www.medworm.com/index.php?rid=4715695&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111000594%2Fabstract%3Frss%3Dyes Conclusion: In non-lesional HPV8-CER transgenic skin StefinA and Sprr2 were found to be indirect/direct transcriptional targets of HPV8. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4715695 Sun, 03 Apr 2011 23:00:00 +0100 4715695 http://www.medworm.com/index.php?rid=4715700&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111000776%2Fabstract%3Frss%3Dyes Conclusion: The optimized method to screen the OCA mutations is efficiently implemented in the routine genetic testing of Chinese OCA patients accompanied with genetic counseling. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4715700 Thu, 31 Mar 2011 23:00:00 +0100 4715700 http://www.medworm.com/index.php?rid=4715699&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS092318111100079X%2Fabstract%3Frss%3Dyes Conclusions: The expression of c-Kit, p-ERK, and cyclin D1 might help to differentiate thin melanoma from melanocytic nevus, but it appears to lack prognostic potential. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4715699 Thu, 31 Mar 2011 23:00:00 +0100 4715699 http://www.medworm.com/index.php?rid=4715696&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111000259%2Fabstract%3Frss%3Dyes Conclusion: UV-based therapies, especially NB-UVB and excimer lamp treatments, may be effective therapeutic methods for pruritus involving epidermal hyperinnervation. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4715696 Thu, 31 Mar 2011 23:00:00 +0100 4715696 http://www.medworm.com/index.php?rid=4644748&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111000661%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4644748 Tue, 29 Mar 2011 15:51:54 +0100 4644748 http://www.medworm.com/index.php?rid=4644736&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111000624%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4644736 Tue, 29 Mar 2011 15:51:52 +0100 4644736 http://www.medworm.com/index.php?rid=4715702&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111000582%2Fabstract%3Frss%3Dyes Thymic stromal lymphopoietin (TSLP) is an interleukin (IL)-7 like cytokine, originally cloned from a murine thymic cell line, which plays a key role in allergic inflammation by activating dendritic cell to induce naïve T cells to differentiate into Th2 cells . Overexpression of the TSLP gene specifically in airway epithelial cells or keratinocytes led to asthma- and atopic dermatitis (AD)-like disease, respectively . Furthermore, TSLP is highly expressed by keratinocytes in skin lesions of patients with AD and by bronchi of asthmatic patients, and its levels of expression is correlated with severity of diseases . However, the regulation of TSLP expression in epithelial cells and molecular pathways regulating this production has not been fully elucidated. Recently, we have shown that polyi... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4715702 Sun, 27 Mar 2011 23:00:00 +0100 4715702 http://www.medworm.com/index.php?rid=4715701&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111000569%2Fabstract%3Frss%3Dyes Hypertrophic scar is a fibroproliferative disorder of the dermis characterized by increased collagen and other extracellular matrix proteins . Caveolin 1 (cav-1) is the most important member of a family of membrane proteins that are the major coating proteins of caveolae and founded primarily in adherent cells and regulates transforming growth factor beta1 (TGF-β1) signaling , preventing Smad2 phosphorylation , and/or mediating TGF-β receptor turnover . Moreover, the physiological importance of cav-1 in fibrosis has recently been highlighted in pulmonary disorders such as interstitial fibrosis and systemic sclerosis . Based on these observations, we raised the question of whether cav-1 is involved in the pathogenesis of hypertrophic scar formation. (Source: Journal of Dermatological Scie... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4715701 Sun, 27 Mar 2011 23:00:00 +0100 4715701 http://www.medworm.com/index.php?rid=4715698&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111000545%2Fabstract%3Frss%3Dyes Conclusion: These findings suggest that IFN–MDP-Lys (L18) can be a promising adjuvant therapy for malignant melanoma. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4715698 Thu, 17 Mar 2011 00:00:00 +0100 4715698 http://www.medworm.com/index.php?rid=4715697&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS092318111100051X%2Fabstract%3Frss%3Dyes Conclusions: These results indicated that dermal tissues contain stem cells that express CD44, CD54, CD90, CD105, and CD271 which are stem cell markers. More precisely, it was suggested that both CD54 (+) and CD271 (+) stem cells have high proliferation and differentiation potentials. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4715697 Tue, 08 Mar 2011 00:00:00 +0100 4715697 http://www.medworm.com/index.php?rid=4715694&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111000533%2Fabstract%3Frss%3Dyes Conclusions: Our results suggest that the GV1001 vaccination is not effective in CTCL patients and disease progression in 1/6 patients raises concerns about its safety. By analyzing skin-homing properties of GV1001-specific T cells and the involvement of regulatory T cells we nevertheless provide insight into vaccine-induced immune responses which may help to improve vaccine strategies in CTCL. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4715694 Mon, 07 Mar 2011 00:00:00 +0100 4715694 http://www.medworm.com/index.php?rid=4644739&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111000296%2Fabstract%3Frss%3Dyes Conclusion: Significant evidence exists to suggest that the rs31563 SNP (−4091G/A) located in the IL-9 gene is associated with an increased susceptibility to AD. Similarly, the rs3093467 SNP in IL-9R gene seems to be associated with an increased risk for developing non-allergic AD. In a subsequent gene–gene interaction analysis, the rs31563 GG/rs3093467 TT genotype combination (IL-9/IL-9R) was found to exert a synergistic effect in the development of the AD phenotype. As the classes of helper T cells are diverse and the function of IL-9 cytokine has not been fully described, the cutaneous function of IL-9 needs to be further explored in future studies. (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4644739 Mon, 07 Mar 2011 00:00:00 +0100 4644739 http://www.medworm.com/index.php?rid=4644737&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111000260%2Fabstract%3Frss%3Dyes Abstract: The outer most layer of the skin, the epidermis, is attached to the dermis via a sheet of extracellular matrix proteins termed the basement membrane zone (BMZ). In the intact skin, adhesion of the keratinocytes in the basal layer of the epidermis to the BMZ is facilitated primarily by hemidesmosomes which associate with the keratin cytoskeleton. Cultured keratinocytes do not assemble bona fide hemidesmosomes although hemidesmosome protein clusters (stable anchoring contacts) are found along the substrate-attached surface of the cells and towards the leading edge of keratinocytes repopulating scratch wounds. Actin cytoskeleton-associated matrix adhesion devices termed focal contacts are not thought to play an important role in the adhesion of keratinocytes to the BMZ in intact ski... Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4644737 Mon, 07 Mar 2011 00:00:00 +0100 4644737 http://www.medworm.com/index.php?rid=4595192&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111000399%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4595192 Tue, 01 Mar 2011 00:00:00 +0100 4595192 http://www.medworm.com/index.php?rid=4595180&cid=s_38504_12_f&fid=38504&url=http%3A%2F%2Fwww.jdsjournal.com%2Farticle%2FPIIS0923181111000351%2Fabstract%3Frss%3Dyes (Source: Journal of Dermatological Science) Journal of Dermatological Science journals http://www.medworm.com/rss/comments.php?id=4595180 Tue, 01 Mar 2011 00:00:00 +0100 4595180